Sample records for thyroid-associated ophthalmopathy tao

  1. A musculoskeletal model of low grade connective tissue inflammation in patients with thyroid associated ophthalmopathy (TAO): the WOMED concept of lateral tension and its general implications in disease

    PubMed Central

    Moncayo, Roy; Moncayo, Helga

    2007-01-01

    Background Low level connective tissue inflammation has been proposed to play a role in thyroid associated ophthalmopathy (TAO). The aim of this study was to investigate this postulate by a musculoskeletal approach together with biochemical parameters. Methods 13 patients with TAO and 16 controls were examined. Erythrocyte levels of Zn, Cu, Ca2+, Mg, and Fe were determined. The musculoskeletal evaluation included observational data on body posture with emphasis on the orbit-head region. The angular foot position in the frontal plane was quantified following gait observation. The axial orientation of the legs and feet was evaluated in an unloaded supine position. Functional propioceptive tests based on stretch stimuli were done by using foot inversion and foot rotation. Results Alterations in the control group included neck tilt in 3 cases, asymmetrical foot angle during gait in 2, and a reaction to foot inversion in 5 cases. TAO patients presented facial asymmetry with displaced eye fissure inclination (mean 9.1°) as well as tilted head-on-neck position (mean 5.7°). A further asymmetry feature was external rotation of the legs and feet (mean 27°). Both foot inversion as well as foot rotation induced a condition of neuromuscular deficit. This condition could be regulated by gentle acupressure either on the lateral abdomen or the lateral ankle at the acupuncture points gall bladder 26 or bladder 62, respectively. In 5 patients, foot rotation produced a phenomenon of moving toes in the contra lateral foot. In addition foot rotation was accompanied by an audible tendon snapping. Lower erythrocyte Zn levels and altered correlations between Ca2+, Mg, and Fe were found in TAO. Conclusion This whole body observational study has revealed axial deviations and body asymmetry as well as the phenomenon of moving toes in TAO. The most common finding was an arch-like displacement of the body, i.e. eccentric position, with foot inversion and head tilt to the contra lateral side and tendon snapping. We propose that eccentric muscle action over time can be the basis for a low grade inflammatory condition. The general implications of this model and its relations to Zn and Se will be discussed. PMID:17319961

  2. Exacerbation of thyroid associated ophthalmopathy after arterial embolization therapy in a patient with Graves’ disease

    Microsoft Academic Search

    Tetsuya Hiraiwa; Akihisa Imagawa; Kazuhiro Yamamoto; Hiroshi Arimoto; Takeshi Arishima; Mitsuru Ito; Yasushi Nakamura; Fumio Matsuzuka; Akira Miyauchi; Jun Sugasawa; Tsunehiko Ikeda; Yoshifumi Narumi; Toshiaki Hanafusa

    2009-01-01

    A novel treatment approach to Graves’ disease (GD), embolization of the thyroid gland arteries, is evaluated with respect\\u000a to its indications and adverse effects. We describe an exacerbation of thyroid associated ophthalmopathy (TAO) following thyroid\\u000a artery embolization in a woman with GD and mild stable TAO (NOSPECS classification, class I grade a). A 45-year-old woman\\u000a with GD and inactive TAO,

  3. Cytokine Profiles in Eye Muscle Tissue and Orbital Fat Tissue from Patients with Thyroid-Associated Ophthalmopathy

    Microsoft Academic Search

    YUJI HIROMATSU; DAME YANG; TOMASZ BEDNARCZUK; IKUYO MIYAKE; KYOHEI NONAKA; YOICHI INOUE

    2010-01-01

    Eye muscle (EM) and retroorbital fat tissue are two major sites of involvement in thyroid-associated ophthalmopathy (TAO). Lympho- cytic infiltration in these tissues is a prominent histological feature of TAO. We have investigated the cytokine gene profiles in EM and orbital fat (OF) tissues from patients with TAO. Total RNA was isolated from EM tissue of 14 patients and from

  4. TSH-receptor-expressing fibrocytes and thyroid-associated ophthalmopathy.

    PubMed

    Smith, Terry J

    2015-03-01

    Thyroid-associated ophthalmopathy (TAO) is a vexing and undertreated ocular component of Graves disease in which orbital tissues undergo extensive remodelling. My colleagues and I have introduced the concept that fibrocytes expressing the haematopoietic cell antigen CD34 (CD34(+) fibrocytes), which are precursor cells of bone-marrow-derived monocyte lineage, express the TSH receptor (TSHR). These cells also produce several other proteins whose expression was traditionally thought to be restricted to the thyroid gland. TSHR-expressing fibrocytes in which the receptor is activated by its ligand generate extremely high levels of several inflammatory cytokines. Acting in concert with TSHR, the insulin-like growth factor 1 receptor (IGF-1R) expressed by orbital fibroblasts and fibrocytes seems to be necessary for TSHR-dependent cytokine production, as anti-IGF-1R blocking antibodies attenuate these proinflammatory actions of TSH. Furthermore, circulating fibrocytes are highly abundant in patients with TAO and seem to infiltrate orbital connective tissues, where they might transition to CD34(+) fibroblasts. My research group has postulated that the infiltration of fibrocytes into the orbit, their unique biosynthetic repertoire and their proinflammatory and profibrotic phenotype account for the characteristic properties exhibited by orbital connective tissues that underlie susceptibility to TAO. These insights, which have emerged in the past few years, might be of use in therapeutically targeting pathogenic orbit-infiltrating fibrocytes selectively by utilizing novel biologic agents that interfere with TSHR and IGF-1R signalling. PMID:25560705

  5. Th1, Th2, and Th17 Cytokine Involvement in Thyroid Associated Ophthalmopathy.

    PubMed

    Shen, Jie; Li, Zhangfang; Li, Wenting; Ge, Ying; Xie, Min; Lv, Meng; Fan, Yanfei; Chen, Zhi; Zhao, Defu; Han, Yajuan

    2015-01-01

    To determine serum cytokine profiles in Graves' disease (GD) patients with or without active and inactive thyroid associated ophthalmopathy (TAO), we recruited 65 subjects: 10 GD only (without TAO), 25 GD + active TAO, 20 GD + TAO, and 10 healthy controls. Liquid chip assay was used to measure serum Th1/Th2/Th17 cytokines including IFN-? (interferon-gamma), TNF-? (tumor necrosis factor-alpha), IL-1? (interleukin-1 alpha), IL-1Ra (IL-1 receptor antagonist), IL-2, IL-4, IL-6, and IL-17 and two chemokines: RANTES (regulated upon activation, normal T cell expressed and secreted) and IP-10 (IFN-?-induced protein 10). Serum levels of TSH (thyroid stimulating hormone) receptor autoantibodies (TRAb) were measured using an enzyme linked immunosorbent assay. Compared with healthy controls, TAO patients showed significantly elevated serum levels of IFN-?, TNF-?, IL-1?, IL-4, IL-6, IL-17, and IP-10. Comparing active and inactive TAO, serum Th1 cytokines IFN-? and TNF-? were elevated in active TAO, while serum Th2 cytokine IL-4 was elevated in inactive TAO. Serum Th17 cytokine IL-17 was elevated in GD but reduced in both active and inactive TAO. A positive correlation was found between TRAb and IFN-?, TNF-?, IL-1?, IL-2, IL-4, and IL-6. Taken together, serum Th1/Th2/Th17 cytokines and chemokines reflect TAO disease activity and may be implicated in TAO pathogenesis. PMID:26089587

  6. Th1, Th2, and Th17 Cytokine Involvement in Thyroid Associated Ophthalmopathy

    PubMed Central

    Shen, Jie; Li, Zhangfang; Li, Wenting; Ge, Ying; Xie, Min; Lv, Meng; Fan, Yanfei; Chen, Zhi; Zhao, Defu; Han, Yajuan

    2015-01-01

    To determine serum cytokine profiles in Graves' disease (GD) patients with or without active and inactive thyroid associated ophthalmopathy (TAO), we recruited 65 subjects: 10 GD only (without TAO), 25 GD + active TAO, 20 GD + TAO, and 10 healthy controls. Liquid chip assay was used to measure serum Th1/Th2/Th17 cytokines including IFN-? (interferon-gamma), TNF-? (tumor necrosis factor-alpha), IL-1? (interleukin-1 alpha), IL-1Ra (IL-1 receptor antagonist), IL-2, IL-4, IL-6, and IL-17 and two chemokines: RANTES (regulated upon activation, normal T cell expressed and secreted) and IP-10 (IFN-?-induced protein 10). Serum levels of TSH (thyroid stimulating hormone) receptor autoantibodies (TRAb) were measured using an enzyme linked immunosorbent assay. Compared with healthy controls, TAO patients showed significantly elevated serum levels of IFN-?, TNF-?, IL-1?, IL-4, IL-6, IL-17, and IP-10. Comparing active and inactive TAO, serum Th1 cytokines IFN-? and TNF-? were elevated in active TAO, while serum Th2 cytokine IL-4 was elevated in inactive TAO. Serum Th17 cytokine IL-17 was elevated in GD but reduced in both active and inactive TAO. A positive correlation was found between TRAb and IFN-?, TNF-?, IL-1?, IL-2, IL-4, and IL-6. Taken together, serum Th1/Th2/Th17 cytokines and chemokines reflect TAO disease activity and may be implicated in TAO pathogenesis.

  7. Exacerbation of thyroid associated ophthalmopathy after arterial embolization therapy in a patient with Graves' disease.

    PubMed

    Hiraiwa, Tetsuya; Imagawa, Akihisa; Yamamoto, Kazuhiro; Arimoto, Hiroshi; Arishima, Takeshi; Ito, Mitsuru; Nakamura, Yasushi; Matsuzuka, Fumio; Miyauchi, Akira; Sugasawa, Jun; Ikeda, Tsunehiko; Narumi, Yoshifumi; Hanafusa, Toshiaki

    2009-06-01

    A novel treatment approach to Graves' disease (GD), embolization of the thyroid gland arteries, is evaluated with respect to its indications and adverse effects. We describe an exacerbation of thyroid associated ophthalmopathy (TAO) following thyroid artery embolization in a woman with GD and mild stable TAO (NOSPECS classification, class I grade a). A 45-year-old woman with GD and inactive TAO, in whom thyroid function was stable following blockade of hormone release combined with replacement therapy, underwent embolization of three thyroid arteries. Initially, there were neither adverse effects nor complications; however, the patient developed severe TAO (NOSPECS classification, class IV grade b) 3 months after the arterial embolization. Steroid pulse treatments followed by total thyroidectomy resulted in improvement of the eye signs and symptoms. The clinical course and the serial changes of the thyroglobulin and thyroglobulin-antibody titers suggested that the destruction of thyroid follicles, induced by the arterial embolization, triggered the exacerbation of her TAO. Our experience argues for the use of caution when arterial embolization is considered for GD patients with even the mildest TAO (NOSPECS classification, class I). PMID:19381887

  8. MiRNA-21 promotes fibrosis in orbital fibroblasts from thyroid-associated ophthalmopathy

    PubMed Central

    Bo-ding, Tong; Man-Yi, Xiao; Jie-Xi, Zeng

    2015-01-01

    Purpose This study aimed to determine the role of miR-21 in orbital fibroblasts obtained from donors with thyroid-associated ophthalmopathy (TAO) and to elucidate the regulation of fibrosis by miR-21 in the pathological process of TAO. Methods The expression of miR-21 was investigated in orbital tissues from 26 donors with TAO and 10 donors without TAO. Human orbital fibroblasts were cultivated from TAO donors, and the role of miR-21 in orbital fibroblast proliferation, apoptosis, and differentiation was analyzed. Moreover, the effect of transforming growth factor-beta1 (TGF-?1) on miR-21 expression was also analyzed. In addition, the regulation of miR-21 in TGF-?1-induced collagen production was determined. Results The expression of miR-21 in orbital fibroblasts from TAO was higher than in donors without TAO. Additional experiments demonstrated that miR-21 enhanced proliferation, decreased apoptosis, and promoted differentiation in TAO orbital fibroblasts. Moreover, this study also showed that TGF-?1 induced miR-21 expression in a time- and dose-dependent manner and miR-21 promoted collagen I mRNA expression and total collagen production induced by TGF-?1. Additionally, miR-21 activated the TGF-?1/Smad signaling pathway by enhancing Smad3 phosphorylation. Conclusions The present study shows that miR-21 regulates cell proliferation, apoptosis, and differentiation in orbital fibroblasts from TAO, and acts as a mediator in TGF-?1-induced collagen production. These data predict a close association between miR-21 and orbital muscle fibrosis, and provide a novel therapeutic target for TAO. PMID:25873777

  9. Cytokines are both villains and potential therapeutic targets in thyroid-associated ophthalmopathy: From bench to bedside

    PubMed Central

    Smith, Terry J.

    2014-01-01

    Summary The pathophysiology underlying Graves’ disease and its ocular manifestation, thyroid associated ophthalmopathy (TAO) is incompletely understood. Characterization of the mononuclear cells driving the disease and the cytokines they produce has led to significant advances in our understanding of TAO. This in turn has resulted in the identification of potentially attractive drug targets. For instance, development of inhibitors of specific cytokine pathways for use in other autoimmune diseases now presents an opportunity for their application in TAO. In this paper, we review the rationale for considering anti-cytokine therapy in TAO, evidence linking specific cytokines such as interleukin-6, tumor necrosis factor-?, and interleukin-17 pathways to TAO, and explore the potential for targeting of these pathways as therapy. PMID:25544859

  10. Current Concepts in the Molecular Pathogenesis of Thyroid-Associated Ophthalmopathy

    PubMed Central

    Wang, Yao; Smith, Terry J.

    2014-01-01

    Graves' disease (GD) is a common autoimmune condition. At its core, stimulatory autoantibodies are directed at the thyroid-stimulating hormone receptor (TSHR), resulting in dysregulated thyroid gland activity and growth. Closely associated with GD is the ocular condition known as thyroid-associated ophthalmopathy (TAO). The pathogenesis of TAO remains enigmatic as do the connections between the thyroid and orbit. This review highlights the putative molecular mechanisms involved in TAO and suggests how these insights provide future directions for identifying therapeutic targets. Genetic, epigenetic, and environmental factors have been suggested as contributory to the development of GD and TAO. Thyroid-stimulating hormone receptor and insulin-like growth factor receptor (IGF-1R) are expressed at higher levels in the orbital connective tissue from individuals with TAO than in healthy tissues. Together, they form a functional complex and appear to promote signaling relevant to GD and TAO. Orbital fibroblasts display an array of cell surface receptors and generate a host of inflammatory molecules that may participate in T and B cell infiltration. Recently, a population of orbital fibroblasts has been putatively traced to bone marrow–derived progenitor cells, known as fibrocytes, as they express CD45, CD34, CXCR4, collagen I, functional TSHR, and thyroglobulin (Tg). Fibrocytes become more numerous in GD and we believe traffic to the orbit in TAO. Numerous attempts at developing complete animal models of GD have been largely unsuccessful, because they lack fidelity with the ocular manifestations seen in TAO. Better understanding of the pathogenesis of TAO and development of improved animal models should greatly accelerate the identification of medical therapy for this vexing medical problem. PMID:24651704

  11. Patient Information in Graves' Disease and Thyroid-Associated Ophthalmopathy: Readability Assessment of Online Resources

    PubMed Central

    Denniston, Alastair K.; Boelaert, Kristien; Franklyn, Jayne A.; Durrani, Omar M.

    2014-01-01

    Background: The Internet is a vital source of information for patients hoping to learn more about their disease. Health literacy of the general population is known to be poor, with the U.S. Department of Health and Human Services (USDHHS) recommending that patient-oriented literature be written at a fourth- to sixth-grade reading level to optimize comprehensibility. In this study we assessed the readability of online literature specifically for Graves' disease (GD) and thyroid-associated ophthalmopathy (TAO). Methods: Readability of the content of the top 20 English-language GD patient-oriented online resources and top 30 of the equivalent TAO resources returned by Google search was analyzed. Web pages were identified using the Google search terms “Graves' disease” and “Thyroid-Associated Ophthalmopathy,” respectively. Extraneous text (e.g., hyperlinks, affiliations, disclaimers) was removed. Relevant text proceeded to readability analysis using four validated measures: Flesch Reading Ease Score, Flesch-Kincaid Grade Level, Simple Measure of Gobbledygook, and Gunning-Fog Index. Readability was compared with USDHHS standards. Results: Overall, median word count (with interquartile range [IQR] and range) was 990 (IQR 846, 195–3867), with a median of 18 words per sentence (IQR 4.0, 7.5–28). Median Flesch Reading Ease Score was 46 (IQR 13, 24–64), Flesch-Kincaid Grade Level 11 (IQR 3.0, 7.2–17), Simple Measure of Gobbledygook 13 (IQR 2.0, 9.6–17), and Gunning-Fog Index 13 (IQR 3.0, 9.2–19), each equivalent to a reading level of >11th grade and “difficult” on the USDHHS classification. None of the web pages evaluated had readability scores in accordance with published guidelines. There was no significant difference with the country of origin of each web page, website commercial status, or with pages predominantly focused on GD or TAO. Conclusions: Readability scores for online GD and TAO patient-focused materials are inferior to those recommended. Screening of this online material, as well as subsequent revision, is crucial to increase future patient knowledge, satisfaction, and compliance. PMID:24040878

  12. Atypical Presentation of Hashimoto’s Disease in an Adolescent: Thyroid-Associated Ophthalmopathy

    PubMed Central

    K?rm?z?bekmez, Heves; Ye?iltepe Mutlu, Rahime Gül; Dursun, Fatma; Günay, Murat

    2014-01-01

    Hashitoxicosis is generally differentiated from Graves’ hyperthyroidism by its shorter course and absence of ophthalmopathy. In this case report, we describe an adolescent girl who presented with significant clinical findings of hyperthyroidism, a diffuse goiter with homogenously increased uptake in scintigraphy, and with ocular findings of ophthalmopathy. The thyroid stimulating hormone receptor antibody test was positive, and the family history revealed thyroid-associated ophthalmopathy. Clinical findings supported the diagnosis of Hashimoto’s disease (HD) in the follow-up period. Radioactive iodine uptake investigation was found to be a reliable method for differential diagnosis. Attention was drawn to the rarity of pediatric cases of HD who present with ophthalmopathy. PMID:25541900

  13. Atypical Presentation of Hashimoto's Disease in an Adolescent: Thyroid-Associated Ophthalmopathy.

    PubMed

    K?rm?z?bekmez, Heves; Ye?iltepe Mutlu, Rahime Gül

    2014-12-01

    Hashitoxicosis is generally differentiated from Graves' hyperthyroidism by its shorter course and absence of ophthalmopathy. In this case report, we describe an adolescent girl who presented with significant clinical findings of hyperthyroidism, a diffuse goiter with homogenously increased uptake in scintigraphy, and with ocular findings of ophthalmopathy. The thyroid stimulating hormone receptor antibody test was positive, and the family history revealed thyroid-associated ophthalmopathy. Clinical findings supported the diagnosis of Hashimoto's disease (HD) in the follow-up period. Radioactive iodine uptake investigation was found to be a reliable method for differential diagnosis. Attention was drawn to the rarity of pediatric cases of HD who present with ophthalmopathy. PMID:25541900

  14. Rituximab treatment of patients with severe, corticosteroid-resistant thyroid-associated ophthalmopathy

    PubMed Central

    Chong, Kelvin K.L.; Khanna, Dinesh; Afifiyan, Nikoo F.; Hwang, Catherine J; Lee, Diana K.; Chokron Garneau, Helene; Goldberg, Robert A.; Darwin, Christine H; Smith, Terry J; Douglas, Raymond S.

    2009-01-01

    Purpose To study the effectiveness of anti-CD20 (Rituximab, RTX, Rituxan®, Genentech Inc. USA) therapy in patients with severe, corticosteroid (CS)-resistant thyroid-associated ophthalmopathy (TAO). Design Retrospective interventional case series Participants Six consecutive subjects with severe, progressive TAO unresponsive to CS. Methods Electronic medical record review of consecutive patients receiving RTX during the previous 18 months. Responses to therapy were graded using standard clinical assessment and flow-cytometric analysis of peripheral lymphocytes. Main outcome measures Clinical activity score (CAS), proptosis, strabismus, treatment side-effects, and quantification of regulatory T cells. Results Six patients were studied. Systemic CS failed to alter clinical activity in all patients (CAS= 5.3 + 1.0 (mean + standard deviation) before vs 5.5 + 0.8 during therapy for 7.5+ 6.4 months, p=1.0). However following RTX treatment, CAS improved from 5.5 + 0.8 to 1.3 + 0.5 at 2 months post treatment (p<0.03) and remained quiescent in all patients (CAS=0.7 + 0.8; p?0.0001) at 6.2 + 4.5 month follow-up. Vision improved bilaterally in all 4 patients with dysthyroid optic neuropathy (DON). None of the six patients experienced disease relapse following RTX infusion and proptosis remained stable (Hertel measurement = 24 + 3.7mm before and 23.6 + 3.7mm after therapy, p=0.17). The abundance of T regulatory cells, assessed in one patient, increased within one week of RTX and remained elevated at 18 month follow-up. Conclusions In progressive, CS-resistant TAO, rapid and sustained resolution of orbital inflammation and DON followed treatment with RTX. PMID:19818507

  15. Presence of thyroid-associated ophthalmopathy in Hashimoto's thyroiditis

    PubMed Central

    Kan, Emrah; Kan, Elif Kilic; Ecemis, Gülcin; Colak, Ramis

    2014-01-01

    AIM To determine the prevalence of ophthalmopathy in Hashimoto's patients and to make a comparison in subgroups of patients METHODS The study involved 110 Hashimoto's thyroiditis patients and 50 control subjects attending to the endocrinology department of the hospital. Subgroup classification of patients was made as euthyroid, subclinic and clinic in Hashimato's thyroiditis. All patients were evaluated by a single experienced ophthalmologist for the prevalence and characteristics of eye signs. RESULTS The overall prevalences of eye changes were 22.7% (25 patients) in patients and 4% (2 persons) in control subjects respectively (P=0.002). In patients the most common symptom was retrobulbar eye pain with or without any eye movement. Thirteen patients had significant upper eyelid retraction (11.8%). Six patients had eye muscle dysfunction as reduced eye movements in up gaze. In control patients one person had proptosis and another had lid retraction. The clinical activity score and classification of the ophthalmopathy did not show any significant differences among subgroups. CONCLUSION The eye signs were mostly mild (22.7%) and the most common eye sign was the presence of upper eyelid retraction (11.8%). Additionally six patients had eye muscle dysfunction as reduced eye movements in up gaze. Therefore we recommend to make a routine ophthalmic examination in Hashimoto's thyroiditis patients in order not to omit the associated ophthalmopathy. PMID:25161935

  16. Effect of radiotherapy on moderate and severe thyroid associated ophthalmopathy: a double blind and self-controlled study

    PubMed Central

    Wu, Yujie; Tong, Boding; Luo, Yongheng; Xie, Guiyuan; Xiong, Wei

    2015-01-01

    Objective: The effect of radiotherapy on moderate and severe Thyroid associated ophthalmopathy (TAO) was evaluated by various objective and quantitative indexes including T2 signal intensity ratios of orbital MRI inferior rectus and ipsilateral temporal muscle (T2SIR), extraocular muscles (EOM) volume, and the degree of exophthalmos using clinical research with prospective, randomized, double blind, self controlled. Methods: The patients with TAO who in the moderate and severe active period and had similar double eyes condition in the Outpatient Department of Ophthalmology of Xiangya No. 2 Hospital of Central South University from 2011.2 to 2014.2 were selected as objects in this study. The related body check was finished after the research group was built. For the object, one eye of patient having random radiotherapy was chosen as the experimental eye. The other eye in the same patient with pseudo radiotherapy (merely known by operator, doctors in department of ophthalmology and patients were double blind) was selected as the control eye. The radiotherapy plan was made by the operator according to the CT results. The T2 signal intensity ratios of orbital MRI inferior rectus and ipsilateral temporal muscle (T2SIR), extraocular muscles (EOM) volume, and the exophthalmos degree was compared by MRI check to evaluate the effect of radiotherapy. Results: The T2 signal intensity ratios of orbital MRI inferior rectus and ipsilateral temporal muscle (T2SIR), extraocular muscles (EOM) volume, and the exophthalmos degree between both eyes (experimental and control eyes) had significant differences and these data had statistical significance. Conclusions: The treatment of radiotherapy is effective for the TAO in the moderate and severe active period. PMID:25932139

  17. Thyrotropin Receptor and CD40 Mediate Interleukin-8 Expression in Fibrocytes: Implications for Thyroid-Associated Ophthalmopathy (An American Ophthalmological Society Thesis)

    PubMed Central

    Douglas, Raymond S.; Mester, Tünde; Ginter, Anna; Kim, Denise S.

    2014-01-01

    Purpose: To better understand the pathogenesis of thyroid-associated orbitopathy (TAO) through elucidating the role of thyrotropin receptor (TSHR) and CD40 in the expression of interleukin-8 (IL-8) in peripheral blood fibrocytes. Fibrocytes infiltrate the orbit of patients with TAO, where they differentiate into fibroblasts. Fibrocyte precursors occur with increased frequency in the peripheral blood expressing TSHR and CD40 in TAO patients. We hypothesize that in vitro derived fibrocytes and peripheral blood fibrocyte precursors express proinflammatory chemoattractant molecules including IL-8 initiated by TSHR and CD40 signaling. Since nearly all TAO patients express activating antibodies to TSHR, this is particularly relevant for activation of peripheral blood fibrocytes. Methods: TSHR and CD40 expression on peripheral blood fibrocytes was determined by flow cytometry. IL-8 RNA was quantitated by real-time polymerase chain reaction. IL-8 protein production was measured by Luminex and flow cytometry. Thyroid-stimulating hormone and CD40 ligand–stimulated phosphorylation of Akt in peripheral blood fibrocytes was studied by flow cytometry. Results: Both TSHR- and CD40-mediated signaling lead to IL-8 expression in mature fibrocytes. Fibrocyte precursors assayed directly from circulating peripheral blood demonstrate intracellular IL-8 expression with addition of thyroid-stimulating hormone or CD40 ligand. TSHR- and CD40-induced IL-8 production is mediated by Akt phosphorylation. Conclusions: Peripheral blood TSHR+ and CD40+ fibrocytes express IL-8 and may promote the recruitment of inflammatory cells, mitogenesis, and tissue remodeling in TAO. TSHR- and CD40-mediated IL-8 signaling is mediated by Akt. Delineating the molecular mechanisms of fibrocyte immune function may provide potential therapeutic targets for TAO. PMID:25411513

  18. Treatment of Graves' disease and associated ophthalmopathy with the anti-CD20 monoclonal antibody rituximab: an open study

    Microsoft Academic Search

    Mario Salvi; Guia Vannucchi; Irene Campi; Davide Dazzi; Simona Simonetta; Paola Bonara; Stefania Rossi; Clara Sina; Claudio Guastella; Roberto Ratiglia; Paolo Beck-Peccoz

    2007-01-01

    Introduction: Hyperthyroid Graves' disease (GD) is a B-cell-mediated condition caused by TSH receptor antibodies (TRAb), which decline when GD remits. Anti-CD20 monoclonal antibody rituximab (RTX) induces transient B-cell depletion that may potentially modify the active inflammatory phase of thyroid-associated ophthalmopathy (TAO). Methods: Nine patients with GD, (seven with active TAO, two with mild lid signs) were studied. The trial was

  19. Serum concentrations of proinflammatory cytokines in Graves' disease: effect of treatment, thyroid function, ophthalmopathy and cigarette smoking

    Microsoft Academic Search

    Mario Salvi; Mario Pedrazzoni; Giuseppe Girasole; Nicola Giuliani; Roberta Minelli; Jack R Wall; Elio Roti

    2000-01-01

    Objective: In the present study we have measured the concentrations of interleukin-6 (IL-6), soluble IL- 6 receptor (sIL-6R), tumor necrosis factor-a (TNF-a), interleukin-1b (IL-1b) and IL-1 receptor antagonist (IL-1Ra) in the serum of patients with Graves' disease (GD). By multivariate analysis, we have evaluated the effect of antithyroid treatment, thyroid function, the presence or absence of active thyroid-associated ophthalmopathy (TAO),

  20. Thyroid associated orbitopathy

    PubMed Central

    Verma, Rajesh; Gupta, Mani; Mehta, Vinod Kumar

    2013-01-01

    Thyroid-associated orbitopathy (TAO) is a self-limiting auto-immune condition usually associated with Grave's disease. It is characterised by ocular pain, eyelid swelling, chemosis, proptosis and keratopathy. As the mechanism for ophthamoplegia and optic neuropathy is the orbital swelling leading to mechanical restriction of ocular muscles and compression of optic nerve, one expects proptosis rather than ptosis in TAO. We describe a case of a young adult woman who presented with acute onset restriction of movement along with partial ptosis and severe diminution of vision in left eye. The MRI of orbit revealed significant swelling of recti along with signal alteration consistent with TAO. The radio-isotope thyroid scan revealed thyroiditis, and thyroid peroxidase (TPO) antibody was significantly high; hence, the diagnosis of Hashimoto thyroiditis was considered. A course of intravenous methylprednisolone followed by oral steroid was administered, which produced marked improvement in vision and extraocular movement. PMID:23737589

  1. Hashimoto's ophthalmopathy.

    PubMed

    Tateno, Fuyuki; Sakakibara, Ryuji; Kishi, Masahiko; Ogawa, Emina

    2011-07-01

    The authors reported 2 cases of Hashimoto's ophthalmopathy. These cases presented with no preceding illness; euthyroid state; acute presentation of painful or painless ophthalmoplegia, preferentially affecting the lateral rectus muscles; positive antithyroglobulin/antithyroid peroxidase antibodies and good responses to steroid treatment. Awareness of this atypical form of ophthalmopathy is important, as glucocorticoid treatment results in a significant improvement of this disorder. PMID:21701269

  2. American Thyroid Association

    MedlinePLUS

    ... Join TEAM THYROID at the “Most Beautiful Urban Marathon in America “ ® The American Thyroid Association (ATA) is ... charity at the Medtronic Twin Cities in Motion Marathon Weekend 2015 to support thyroid research. Register Today ! ...

  3. Extra-ocular muscle cells from patients with Graves' ophthalmopathy secrete ? (CXCL10) and ? (CCL2) chemokines under the influence of cytokines that are modulated by PPAR?.

    PubMed

    Antonelli, Alessandro; Ferrari, Silvia Martina; Corrado, Alda; Franceschini, Stefano Sellari; Gelmini, Stefania; Ferrannini, Ele; Fallahi, Poupak

    2014-11-01

    To our knowledge, no study has evaluated the involvement of T helper (Th)1- and Th2-chemokines in extra-ocular muscle (EOM) myopathy in "patients with thyroid-associated ophthalmopathy" (TAO-p). We tested the effects of interferon (IFN)? and tumor necrosis factor (TNF)? stimulation, and of increasing concentrations of peroxisome proliferator-activated receptor (PPAR)? agonists (pioglitazone or rosiglitazone; 0.1 ?M-20 ?M), on Th1-chemokine [C-X-C motif ligand (CXCL)10] and Th2-chemokine [C-C motif ligand (CCL)2] secretion in primary EOM cultures from TAO-p vs. control myoblasts. Moreover, we evaluated serum CXCL10 and CCL2 in active TAO-p with prevalent EOM involvement (EOM-p) vs. those with prevalent orbital fat expansion (OF-p). Serum CXCL10 was higher in OF-p and EOM-p vs. controls, while serum CCL2 was not significantly different in controls, or in OF-p and EOM-p. We showed the expression of PPAR? in EOM cells. In primary EOM cultures from TAO-p: a) CXCL10 was undetectable in the supernatant, IFN? dose-dependently induced it, whereas TNF? did not; b) EOM produced basally low amounts of CCL2, TNF? dose-dependently induced it, whereas IFN? did not; c) the combination of TNF? and IFN? had a significant synergistic effect on CXCL10 and CCL2 secretion; and d) PPAR? agonists have an inhibitory role on the modulation of CXCL10, while they stimulate CCL2 secretion. EOM participates in the self-perpetuation of inflammation by releasing both Th1 (CXCL10) and Th2 (CCL2) chemokines under the influence of cytokines, in TAO. PPAR? agonist activation plays an inhibitory role on CXCL10, but stimulates the release of CCL2. PMID:25172242

  4. Thyroid-associated orbitopathy is linked to gastrointestinal autoimmunity.

    PubMed

    Ponto, K A; Schuppan, D; Zwiener, I; Binder, H; Mirshahi, A; Diana, T; Pitz, S; Pfeiffer, N; Kahaly, G J

    2014-10-01

    Common autoimmune disorders tend to co-exist in the same subjects and cluster in families. The objective of this study was to determine the prevalence of autoimmune co-morbidity in patients with autoimmune thyroid disease (AITD) with and without thyroid-associated orbitopathy (TAO). This was a cross-sectional study conducted at an academic tertiary referral centre. Of 1310 patients with AITD [n?=?777 or 59% with Graves' disease (GD) and n?=?533, 41% with Hashimoto's thyroiditis (HT)] followed at a specialized joint thyroid-eye out-patient clinic, 176 (13·4%) had an adult type of the autoimmune polyglandular syndrome, 129 (9·8%) type 1 diabetes, 111 (8·5%) coeliac disease, 60 (4·6%) type A autoimmune gastritis, 57 (4·4%) vitiligo and 25 (1·9%) Addison's disease. Coeliac disease and autoimmune gastritis were associated positively with GD [odds ratio (OR)?=?2·18; P?=?0·002 and OR?=?6·52; P?TAO, 584 (95·7%) and 26 (4·3%) had GD and HT, respectively (P?TAO was most prevalent in GD patients with coeliac disease (94%, OR?=?1·87, P?TAO while type 1 diabetes, Addison's disease and alopecia areata were protective for TAO. In patients with TAO, coeliac disease is the most prevalent co-morbid autoimmune condition and rates are increased compared to GD patients without TAO. PMID:24903731

  5. Dysthyroid Ophthalmopathy: An Update

    PubMed Central

    Young, Lois A.

    1979-01-01

    Since the original description of dysthyroid ophthalmopathy, much has been learned about its etiology, pathology, course, and management. The subject is reviewed in depth and the author suggests explanations relating to some of the poorly understood aspects of the disorder. ImagesFigure 1 PMID:583054

  6. Corneal astigmatism in Graves' ophthalmopathy

    Microsoft Academic Search

    I Mombaerts; S Vandelanotte; L Koornneef

    2006-01-01

    PurposeTo describe corneal astigmatism in patients under the age of 55 years with Graves' ophthalmopathy and to compare it to a control group.MethodsRetrospective, nonrandomized comparative observational case series. A total of 109 patients with inactive Graves' ophthalmopathy and 109 age- and gender-matched control individuals without Graves' ophthalmopathy were examined with manual corneal keratometry. In the Graves' patients, 52% had a

  7. The influence of surgery on endocrine ophthalmopathy

    Microsoft Academic Search

    Andrea Frilling; Peter E. Goretzki; Martin Grußendorf; Markus Erbslöh; Hans-D. Röher

    1990-01-01

    Since the pathogenesis of endocrine ophthalmopathy is unclear, there has been little agreement on the treatment of the disease. The influence of thyroid surgery on endocrine ophthalmopathy is controversial. To evaluate the effect of thyroid surgery on the course of the disease, we developed a special ophthalmopathy index. As a standard procedure, subtotal thyroidectomy with thyroid remnants of 3–5 g

  8. Eyelid surgery in dysthyroid ophthalmopathy

    Microsoft Academic Search

    A Hedin

    1988-01-01

    Dysthyroid ophthalmopathy often gives rise to functional and cosmetic problems due to eyelid retraction. There are several causes of this state which are usually most obvious in the upper lid. Surgery should be delayed until the condition is stable and other operations have been done. A number of operative procedures have been used. In the upper eyelid, the traction of

  9. Clinical Presentation of Graves’ Ophthalmopathy

    Microsoft Academic Search

    W. M. Wiersinga; T. Smit; R. van der Gaag; M. Mounts; L. Koomneef

    1989-01-01

    The eye findings of Graves’ ophthalmopathy were prospectively recorded in 90 consecutive untreated patients (66 females, 24 males; mean age 44.5 years) according to the 1977 NOSPECS classification. Soft-tissue involvement was observed in 90%, proptosis ? 23 mm in 30%, eye muscle involvement in 60%, corneal involvement in 9% and sight loss in 34%. No differences in the distribution of

  10. Characterization and outcomes of repeat orbital decompression for thyroid-associated orbitopathy.

    PubMed

    Zhang-Nunes, Sandy X; Dang, Sabin; Garneau, Helene Chokron; Hwang, Catherine; Isaacs, David; Chang, Shu-Hong; Goldberg, Robert

    2015-04-01

    Orbital decompression for thyroid-associated orbitopathy (TAO) is commonly performed for disfiguring proptosis, congestion, and optic neuropathy. Although one decompression typically achieves goals, a small percentage requires repeat decompression. We performed a 10-year retrospective chart review of all orbital decompressions for TAO at a single tertiary referral institution. Four-hundred and ninety-five orbits (330 patients) were decompressed for TAO, with 45 orbits (37 patients) requiring repeat decompression. We reviewed the repeat cases for indications, clinical activity scores, approach, walls decompressed, and outcomes. Nine percent of orbits required repeat decompression for proptosis (70%), optic neuropathy (25%) or congestion (45%). Sixty-four percent were for recurrence of disease, 36% were for suboptimal decompression. Three incisional approaches were used: lateral upper eyelid crease, inferior transconjunctival, and transcaruncular, with inferior transconjunctival being most common. Of the three walls removed, deep lateral, inferior, and medial, the deep lateral wall was most common (51%). A repeat lateral decompression was the most frequent pattern. Of 37 patients requiring repeat decompression, 40% had diplopia prior to repeat, and an additional 24% developed diplopia after the repeat. Whereas previous studies published by our group cited only 2.6% of deep lateral wall orbital decompressions leading to new-onset primary gaze diplopia, repeat orbital decompressions have a much higher rate of post-operative diplopia. The new onset primary gaze diplopia after repeat decompression group had a higher average preoperative CAS (3.3 vs. 2.4, p?

  11. Management of Graves' Ophthalmopathy: Reality and Perspectives

    Microsoft Academic Search

    LUIGI BARTALENA; ALDO PINCHERA; CLAUDIO MARCOCCI

    2000-01-01

    Graves' ophthalmopathy is an debilitating disease impairing the quality of life of affected individuals. Despite recent progress in the understanding of its pathogenesis, treatment is often not satisfactory. In mild cases, local therapeutic measures (artificial tears and oint- ments, sunglasses, nocturnal taping of the eyes, prisms) can control symptoms and signs. In severe forms of the disease (3-5%), aggressive measures

  12. Mechanisms of Immune Damage in Graves’ Ophthalmopathy

    Microsoft Academic Search

    Yuji Hiromatsu; Pei Wen Wang; Len Wosu; Jacques How; Jack R. Wall

    1987-01-01

    We have studied the role of immunologically mediated cytotoxicity in the orbital tissue damage of Graves’ ophthalmopathy. Antibody-dependent cell-mediated cytotoxicity (ADCC) against eye muscle (EM) cells and orbital fibroblasts (OF) was demonstrated in a small proportion of patients, all of whom had severe, recent disease. Antibody-mediated (complement-dependent) cytotoxicity against OF was found in only a few patients. No patients showed

  13. Coronal approach for rehabilitative orbital decompression in Graves’ ophthalmopathy

    Microsoft Academic Search

    Rachel Kalmann; Maarten Ph Mourits; Jeroen P van der Pol; Leo Koornneef

    1997-01-01

    AIMSTo determine the effectiveness and safety of three wall orbital decompression by the coronal approach in Graves’ ophthalmopathy.METHODSThe records of 125 patients with Graves’ ophthalmopathy, who had undergone three wall orbital decompression by coronal approach between April 1984 and October 1993, were studied retrospectively. Special attention was paid to proptosis reduction, changes in ocular motility, and complications.RESULTSThe preoperative Hertel values

  14. Treatment of Graves' disease and the course of ophthalmopathy

    Microsoft Academic Search

    Vitaya Sridama; Leslie J. DeGroot

    1989-01-01

    Contradictory results have been obtained with regards to the effect of various treatment modes on the exacerbation of Graves' ophthalmopathy, probably because the number of patients in each study was small and some studies were analyzed only in relation to one type of treatment. To circument these problems, we studied the course of Graves' ophthalmopathy after various modes of therapy

  15. TAO users manual.

    SciTech Connect

    Benson, S.; McInnes, L. C.; More, J. J.; Sarich, J.

    2003-12-02

    The Toolkit for Advanced Optimization (TAO) focuses on the design and implementation of component-based optimization software for the solution of large-scale optimization applications on high-performance architectures. Their approach is motivated by the scattered support for parallel computations and lack of reuse of linear algebra software in currently available optimization software. The TAO design allows the reuse of toolkits that provide lower-level support (parallel sparse matrix data structures, preconditioners, solvers), and thus they are able to build on top of these toolkits instead of having to redevelop code. The advantages in terms of efficiency and development time are significant. The TAO design philosophy uses object-oriented techniques of data and state encapsulation, abstract classes, and limited inheritance to create a flexible optimization toolkit. This chapter provides a short introduction to the design philosophy by describing the objectives in TAO and the importance of this design. Since a major concern in the TAO project is the performance and scalability of optimization algorithms on large problems, they also present some performance results.

  16. Teaching in the Tao.

    ERIC Educational Resources Information Center

    Christie, Patrick

    This book shares the philosophy that what a teacher learned through the martial arts form, Aikido, allowed him to look beyond aggressive acts without responding aggressively himself, viewing the student behind the angry behavior. The teacher notes that compassion works better than any form of discipline he has ever encountered in education. Tao,…

  17. HARMONIC ANALYSIS TERENCE TAO

    E-print Network

    Tao, Terence

    HARMONIC ANALYSIS TERENCE TAO Analysis in general tends to revolve around the study of general functions as input, and return some other function as output). Harmonic analysis1 focuses in particular Strictly speaking, this sentence describes the field of real-variable harmonic analysis. There is another

  18. Conflict and Tao.

    ERIC Educational Resources Information Center

    Crawford, Lyall

    What can philosophical Taoism teach us about interpersonal conflict and effective approaches for dealing with it? Examination of selected portions of the R. Hendricks translation of the "Lao-Tzu" or "Te-Tao Ching," and experiences recorded in fieldnotes while a member of a Taoist commune suggest a four-point protocol for managing interpersonal…

  19. 3D-MRI rendering of the anatomical structures related to acupuncture points of the Dai mai, Yin qiao mai and Yang qiao mai meridians within the context of the WOMED concept of lateral tension: implications for musculoskeletal disease

    Microsoft Academic Search

    Roy Moncayo; Ansgar Rudisch; Christian Kremser; Helga Moncayo

    2007-01-01

    BACKGROUND: A conceptual model of lateral muscular tension in patients presenting thyroid associated ophthalmopathy (TAO) has been recently described. Clinical improvement has been achieved by using acupuncture on points belonging to the so-called extraordinary meridians. The aim of this study was to characterize the anatomical structures related to these acupuncture points by means of 3D MRI image rendering relying on

  20. Severe eyelid oedema in Graves’ ophthalmopathy

    PubMed Central

    Anagnostis, Panagiotis; Adamidou, Fotini; Poulasouchidou, Maria; Karras, Spyridon

    2013-01-01

    We report a case of severe eyelid oedema due to Graves’ ophthalmopathy (GO). The aim was to present a case report and review of the literature about eyelid oedema due to GO. The case report includes a history of patient data and literature review. The patient was offered intravenous methylprednisolone and gave consent. A dosage of 500?mg intravenous methylprednisolone once weekly for 6?weeks, followed by 250?mg intravenous methylprednisolone once weekly for 6?weeks, with a total treatment period of 12?weeks was given. Up to day, minor improvement has been observed. Severe eyelid oedema due to GO is a rare manifestation of Graves’ disease. In cases of active and moderate-to-severe disease, treatment with intravenous glucorticoids is recommended alone or with orbital radiotherapy, followed by rehabilitative surgery. PMID:23853193

  1. Radiation retinopathy after orbital irradiation for Graves' ophthalmopathy

    SciTech Connect

    Kinyoun, J.L.; Kalina, R.E.; Brower, S.A.; Mills, R.P.; Johnson, R.H.

    1984-10-01

    Recent reports indicate that orbital irradiation for Graves' ophthalmopathy is sometimes beneficial, particularly for dysthyroid optic neuropathy, and is not associated with serious complications. We are aware, however, of four patients who were found to have radiation retinopathy after orbital irradiation for Grave's ophthalmopathy. All four patients have decreased central acuity, and three of the four are legally blind in one or both eyes. Computer reconstruction of the dosimetry, based on computed tomography and beam profiles, shows that errors in dosage calculations and radiotherapy technique probably account for the radiation retinopathy in three of the four patients. Radiotherapy for Graves' ophthalmopathy should be administered only by competent radiotherapists who are experienced in the treatment of this disease. Similar errors in dosage calculations and treatment techniques may account for other reports of radiation retinopathy after reportedly safe dosages.

  2. Toward the Tao of Giftedness.

    ERIC Educational Resources Information Center

    Richert, E. Susanne

    1986-01-01

    The author considers the need for a philosophical foundation for gifted education and suggests the Tao Te Ching education can reconcile the dichotomies in the field and encompass the various cognitive, affective, ethical, and esthetic taxonomies in existence. (CL)

  3. Graves' ophthalmopathy evaluated by infrared eye-movement recordings

    SciTech Connect

    Feldon, S.E.; Unsoeld, R.

    1982-02-01

    Thirteen patients with varying degrees of Graves' ophthalmopathy were examined using high-resolution infrared oculography to determine peak velocities for horizontal eye movements between 3 degrees and 30 degrees. As severity of the orbital disease increased, peak velocities became substantially lower. Vertical-muscle surgery failed to have any effect on peak velocity of horizontal eye movements. In contrast, orbital decompression caused notable improvement in peak velocity of eye movements. Eye-movement recordings, which provide a measure of extraocular muscle function rather than structure, may provide a safe, sensitive, and accurate method for classifying and following up patients with Graves' ophthalmopathy.

  4. Graves' ophthalmopathy: I. Simple CT estimates of extraocular muscle volume

    Microsoft Academic Search

    E S Hallin; S E Feldon

    1988-01-01

    Graves' ophthalmopathy is an autoimmune inflammatory process affecting primarily the extraocular muscles. The enlargement of these muscles is responsible for most of the important manifestations of the disease, including proptosis, lid retraction, diplopia, and optic neuropathy. Recently the optic neuropathy has been shown to correlate with extraocular muscle volume as determined by computed tomography (CT). In the present study simplified

  5. Prognostic factors in the radiotherapy of Graves' ophthalmopathy

    Microsoft Academic Search

    Ivy A Petersen; Joseph P Kriss; I. Ross McDougall; Sarah S Donaldson

    1990-01-01

    Between April 1968 and February 1988, 311 patients with symptomatic and progressive Graves' ophthalmopathy were treated with megavoltage orbital radiotherapy. The patients were divided into three groups: I treated with 20 Gy\\/2 weeks; II treated with 30 Gy\\/3 weeks, and III received 20 Gy\\/2 weeks. The degree of eye involvement was evaluated numerically before and after therapy for each of

  6. Current Perspective on the Pathogenesis of Graves' Disease and Ophthalmopathy

    Microsoft Academic Search

    BELLUR S. PRABHAKAR; REBECCA S. BAHN; TERRY J. SMITH

    2010-01-01

    Graves' disease (GD) is a very common autoimmune disorder of the thyroid in which stimulatory antibodies bind to the thyrotropin receptor and activate glandular function, result- ing in hyperthyroidism. In addition, some patients with GD develop localized manifestations including ophthalmopathy (GO) and dermopathy. Since the cloning of the receptor cDNA, significant progress has been made in understanding the structure-function relationship

  7. Treatment of Graves' disease and the course of ophthalmopathy

    SciTech Connect

    Sridama, V.; DeGroot, L.J.

    1989-07-01

    Contradictory results have been obtained with regards to the effect of various treatment modes on the exacerbation of Graves' ophthalmopathy, probably because the number of patients in each study was small and some studies were analyzed only in relation to one type of treatment. To circument these problems, we studied the course of Graves' ophthalmopathy after various modes of therapy for thyrotoxicosis among 537 patients with Graves' disease. A total of 537 patients with Graves' disease were prospectively studied over an 11-year period. Thirty-one patients were lost to follow-up during the first six months after treatment and were excluded from the study. Of those remaining, 426 received one form of treatment, 79 received two kinds of therapy, and one received three kinds of therapy. Thus, surgical treatments numbered 164, radioactive iodine-131 (/sup 13/1I) treatments numbered 241, and medical treatments numbered 182. Ocular signs were considered improved or exacerbated by the following criteria: decrement or increment of the exophthalmos of 2 mm or more, improvement or deterioration of visual acuity, and regression or progression of extraocular muscle involvement causing diplopia. Among patients who did not have infiltrative ophthalmopathy before treatment, there was no difference in the occurrence of posttreatment exophthalmos in the surgically, medically, and 131I-treated patients (7.1%, 6.7%, and 4.9%, respectively). The incidence and the degree of progression of ophthalmopathy in patients who already had exophthalmos before treatment were similar in the medically, surgically, and 131I-treated groups (19.2%, 19.8%, and 22.7%, respectively). Most of the progression occurred in the posttreatment euthyroid stage. The incidence of improvement of ophthalmopathy was also similar 14.1%, 12.6%, and 12.3% in the medically, surgically, and 131I-treated patients.

  8. The effect of subtotal thyroidectomy on Graves' ophthalmopathy

    Microsoft Academic Search

    Michael D. Levitt; Anthony J. Edis; Ross Agnello; Clement C. McCormick

    1988-01-01

    Nineteen unselected patients undergoing subtotal thyroidectomy (STT) for Graves' disease were submitted to thorough ophthalmologic assessment before and after (mean, 10 mo) thyroid surgery. All clinical examinations were performed by the same observer and findings were scored according to the American Thyroid Association (“NOSPECS”) classification. Orbital computed tomography (CT) scans were performed in all patients prior to surgery and again

  9. Change in proptosis following extraocular muscle surgery: Effects of muscle recession in thyroid-associated orbitopathy

    Microsoft Academic Search

    Cintia F. Gomi; Suk-Woo Yang; David B. Granet; Don O. Kikkawa; Kathryn A. Langham; Lydia R. Banuelos; Leah Levi

    2007-01-01

    Thirty-eight eyes in 22 patients with thyroid-associated orbitopathy were studied before and after strabismus surgery. The mean change in exophthalmometry following strabis- mus surgery in all eyes was 0.6 mm ( p 0.01). Eyes with prior decompression averaged a 0.9 mm increase following strabismus surgery ( p 0.01); those without decompression averaged a 0.2 mm decrease ( p 0.658). In

  10. The relationship between Graves’ ophthalmopathy and dry eye syndrome

    PubMed Central

    Selter, Jessica H; Gire, Anisa I; Sikder, Shameema

    2015-01-01

    Background A complex relationship between Graves’ ophthalmopathy (GO) and dry eye syndrome exists. New research brings more insight into the association between these two diseases. Methods A review of the literature was conducted using the query terms “Graves’ Ophthalmopathy”, “Thyroid Eye Disease”, and “Dry Eye” in MedLine (PubMed) and Scopus. A total of 55 papers were reviewed. Case reports were excluded. Conclusion This review paper shows the close relationship between dry eye syndrome and GO. The underlying mechanisms behind their association suggest mechanical impairment of orbital muscles and immune-mediated lacrimal gland dysfunction as the causes of dry eye in GO patients. However, there are a variety of treatment options available for patients with GO with signs of dry eye, which help combat this issue. PMID:25584018

  11. Graves disease with ophthalmopathy following radiotherapy for Hodgkin's disease

    SciTech Connect

    Jacobson, D.R.; Fleming, B.J.

    1984-12-01

    The number of patients achieving long-term survival following neck irradiation for Hodgkin's disease and other malignancies is increasing. Paralleling this increase in survivors is the development of late complications of the therapy itself. Eleven patients have previously been reported who developed Graves ophthalmopathy 18 months to seven years after receiving neck radiotherapy for nonthyroidal malignancies. The seven patients who had HLA typing were all HLA-B8 negative, despite the reported association of the HLA-B8 antigen with Graves disease. A patient who is HLA-B8 positive who developed Graves ophthalmopathy and hyperthyroidism nine years after receiving mantle radiotherapy for Hodgkin's disease is reported. It is recommended that Graves disease be included among the thyroid diseases that receive consideration during follow-up of patients who have received mantle radiotherapy.

  12. Synovial osteochondromatosis in hereditary arthro-ophthalmopathy (Wagner-Stickler syndrome)

    Microsoft Academic Search

    Bernhard Tins; Victor Cassar-Pullicino

    2003-01-01

    A case of bilateral synovial osteochondromatosis in a patient with hereditary arthro-ophthalmopathy is presented. The osteochondral lesions were largely calcified in one joint and largely chondromatous in the other. Typical features of hereditary arthro-ophthalmopathy are reviewed and it is hypothesised that the abnormal collagen in this syndrome is responsible for the development of synovial osteochondromatosis. Synovial manifestations of skeletal dysplasias

  13. Ultrafast consensus via predictive mechanisms Hai-Tao Zhang, Michael ZhiQiang Chen, Tao Zhou and

    E-print Network

    Cambridge, University of

    OFFPRINT Ultrafast consensus via predictive mechanisms Hai-Tao Zhang, Michael ZhiQiang Chen, Tao.epljournal.org doi: 10.1209/0295-5075/83/40003 Ultrafast consensus via predictive mechanisms Hai-Tao Zhang1

  14. Authentication in the Taos Operating System

    E-print Network

    Lampson, Butler W.

    117 Authentication in the Taos Operating System Edward Wobber, Mart'in Abadi, Mike Burrows and the state of the art in computer systems. From our establishment in 1984, we have performed basic, Director #12; Authentication in the Taos Operating System Edward Wobber, Mart'in Abadi, Mike Burrows

  15. American Thyroid Association Guide to Investigating Thyroid Hormone Economy and Action in Rodent and Cell Models

    PubMed Central

    Anderson, Grant; Forrest, Douglas; Galton, Valerie Anne; Gereben, Balázs; Kim, Brian W.; Kopp, Peter A.; Liao, Xiao Hui; Obregon, Maria Jesus; Peeters, Robin P.; Refetoff, Samuel; Sharlin, David S.; Simonides, Warner S.; Weiss, Roy E.; Williams, Graham R.

    2014-01-01

    Background: An in-depth understanding of the fundamental principles that regulate thyroid hormone homeostasis is critical for the development of new diagnostic and treatment approaches for patients with thyroid disease. Summary: Important clinical practices in use today for the treatment of patients with hypothyroidism, hyperthyroidism, or thyroid cancer are the result of laboratory discoveries made by scientists investigating the most basic aspects of thyroid structure and molecular biology. In this document, a panel of experts commissioned by the American Thyroid Association makes a series of recommendations related to the study of thyroid hormone economy and action. These recommendations are intended to promote standardization of study design, which should in turn increase the comparability and reproducibility of experimental findings. Conclusions: It is expected that adherence to these recommendations by investigators in the field will facilitate progress towards a better understanding of the thyroid gland and thyroid hormone dependent processes. PMID:24001133

  16. Clinical criteria for the assessment of disease activity in Graves' ophthalmopathy: a novel approach

    Microsoft Academic Search

    M P Mourits; L Koornneef; W M Wiersinga; M F Prummel; A Berghout; R van der Gaag

    1989-01-01

    Patients with serious inflammatory Graves' ophthalmopathy should be treated with anti-inflammatory drugs or radiotherapy to prevent complications like fibrosis, while those with non-inflammatory ophthalmopathy may be treated by surgery immediately. It is often difficult, however, to distinguish inflammatory from non-inflammatory Graves' disease. We therefore present a simple clinical classification here to differentiate between these two conditions. This classification is based

  17. Use of corticosteroids to prevent progression of Graves' ophthalmopathy after radioiodine therapy for hyperthyroidism

    SciTech Connect

    Bartalena, L.; Marcocci, C.; Bogazzi, F.; Panicucci, M.; Lepri, A.; Pinchera, A. (Univ. of Pisa (Italy))

    1989-11-16

    We studied the effects of radioiodine treatment of hyperthyroidism due to Graves' disease on Graves' ophthalmopathy and the possible protective role of corticosteroids. Between June 1985 and June 1988, 26 patients were randomly assigned to treatment with radioiodine alone (group 1) and 26 to treatment with this agent and concomitant administration of systemic prednisone for four months (group 2). The initial dose of prednisone was 0.4 to 0.5 mg per kilogram of body weight for one month; the drug was gradually withdrawn over the next three months. All patients were evaluated at 3-month intervals for 18 months after they underwent radioiodine therapy. Ocular changes were assessed with the ophthalmopathy index; patients with moderate-to-severe changes (scores greater than or equal to 4) were excluded from the study. Before treatment, 10 patients in group 1 and 5 in group 2 had no evidence of ophthalmopathy: in none of them did ocular symptoms appear after radioiodine therapy. Among the patients in group 1 with an initial ophthalmopathy index greater than or equal to 1, ocular disease worsened in 56 percent (mostly involving soft-tissue changes and extraocular-muscle function) and did not change in 44 percent. In contrast, ophthalmopathy improved in 52 percent and did not change in 48 percent of group 2. The mean ophthalmopathy index increased from 1.5 to 3.0 in group 1 (P less than 0.005) and decreased from 2.2 to 1.3 in group 2 (P less than 0.05). We conclude that systemic corticosteroid treatment prevents the exacerbations of Graves' ophthalmopathy that occur after radioiodine therapy in a substantial proportion of patients with hyperthyroidism who have some degree of ocular involvement before treatment.

  18. TAOS/LS1 development final report

    SciTech Connect

    Phipps, G.S.; Gentry, S.M.; Falls, J.M.; Claassen, P.J.; Alder, G.J.

    1997-12-01

    The Laser Sensor No. 1 (LS1) is a system designed and built by Sandia to detect and report laser illumination of an orbiting satellite. It was launched March 1994 as part of the U.S. Air Force Phillips Laboratory, Technology for Autonomous Operational Survivability (TAOS) satellite program. The engineering details of the system are described in this report. Operation characteristics and results have been reserved for inclusion in a classified Air Force report prepared by the TAOS Program Office of Phillips Laboratory.

  19. 2014 European thyroid association guidelines for the management of subclinical hypothyroidism in pregnancy and in children.

    PubMed

    Lazarus, John; Brown, Rosalind S; Daumerie, Chantal; Hubalewska-Dydejczyk, Alicja; Negro, Roberto; Vaidya, Bijay

    2014-06-01

    This guideline has been produced as the official statement of the European Thyroid Association guideline committee. Subclinical hypothyroidism (SCH) in pregnancy is defined as a thyroid-stimulating hormone (TSH) level above the pregnancy-related reference range with a normal serum thyroxine concentration. Isolated hypothyroxinaemia (defined as a thyroxine level below the 2.5th centile of the pregnancy-related reference range with a normal TSH level) is also recognized in pregnancy. In the majority of SCH the cause is autoimmune thyroiditis but may also be due to iodine deficiency. The cause of isolated hypothyroxinaemia is usually not apparent, but iodine deficiency may be a factor. SCH and isolated hypothyroxinaemia are both associated with adverse obstetric outcomes. Levothyroxine therapy may ameliorate some of these with SCH but not in isolated hypothyroxinaemia. SCH and isolated hypothyroxinaemia are both associated with neuro-intellectual impairment of the child, but there is no evidence that maternal levothyroxine therapy improves this outcome. Targeted antenatal screening for thyroid function will miss a substantial percentage of women with thyroid dysfunction. In children SCH (serum TSH concentration >5.5-10 mU/l) normalizes in >70% and persists in the majority of the remaining patients over the subsequent 5 years, but rarely worsens. There is a lack of studies examining the impact of SCH on the neuropsychological development of children under the age of 3 years. In older children, the evidence for an association between SCH and impaired neuropsychological development is inconsistent. Good quality studies examining the effect of treatment of SCH in children are lacking. PMID:25114871

  20. 77 FR 59703 - Environmental Impact Statement; Taos Regional Airport, Taos, NM

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-28

    ...DEPARTMENT OF TRANSPORTATION Federal Aviation Administration Environmental...Taos, NM AGENCY: Federal Aviation Administration (FAA); DOT...CONTACT: DOT/FAA Southwest Region, Dean McMath, Regional Environmental...relocations, installation of a Remote Transmitter/Receiver,...

  1. Meta-analysis of methylprednisolone pulse therapy for Graves' ophthalmopathy.

    PubMed

    Gao, Guohong; Dai, Jinhui; Qian, Yifeng; Ma, Fei

    2014-11-01

    A meta-analysis was performed to evaluate the efficacy of methylprednisolone pulse therapy for Graves' ophthalmopathy. Eight studies involving 376 patients were included. A higher effective rate was found for patients treated with intravenous glucocorticoids (IVGC) over oral glucocorticoids (OGC) (risk ratio [RR]?=?1.48; 95% confidence interval [CI]?=?1.18-1.86). The combined IVGC and orbital radiotherapy (OR) was markedly more effective than OGC+OR (RR?=?1.40; 95% CI?=?1.11-1.77). IVGC resulted in an obvious reduction of clinical activity score (CAS) compared with OGC, with a weighted mean difference (WMD) of 0.86 (95% CI?=?0.53-1.18). The WMD for the reduction of the CAS between IVGC+OR and OGC+OR was 0.66 (95% CI?=?0.30-1.02). IVGC is an effective treatment and cause fewer adverse events. Limiting the total cumulative dose of methylprednisolone, careful patient selection and monitoring the condition of patients during treatment are necessary. PMID:24617953

  2. Indication and Technique of Transnasal Microscopic Orbital Decompression for Endocrine Ophthalmopathy

    Microsoft Academic Search

    A. May; U. Fries; C. von Ilberg; A. Weber

    2000-01-01

    If endocrine ophthalmopathy progresses despite conservative treatment then indications for surgical decompression are: loss of visual acuity, increasing strabism, and severe keratopathy. Endonasal microsurgery ensures a binocular view onto the intranasal landmarks of the orbital walls and allows simultaneous decompression of the medial and inferior wall as well as a good relief of pressure at the orbital apex. Surgical decompressions

  3. Therapeutic Outcome of Prednisone Medication and of Orbital Irradiation in Patients with Graves’ Ophthalmopathy

    Microsoft Academic Search

    W. M. Wiersinga; T. Smit; A. L. J. Schuster-Uittenhoeve; R. van der Gaag; L. Koornneef

    1988-01-01

    Response to treatment was evaluated prospectively in 58 patients with Graves’ ophthalmopathy. Prednisone, administered to 44 patients, resulted in a favourable response in 29 patients (66%): excellent in 3, good in 10 and fair in 16 subjects; 15 patients (34%) did not respond. Orbital irradiation was administered to 39 patients of whom all except 4 had been treated previously with

  4. Probable risk of tumour induction after retro-orbital irradiation for Graves' ophthalmopathy

    Microsoft Academic Search

    A. Snijders-Keilholz; R. J. W. De Keizer; B. M. Goslings; E. W. C. M. Van Dam; J. Th. M. Jansen; J. J. Broerse

    1996-01-01

    Retrobulbar irradiation for Graves' ophthalmopathy is considered as a safe treatment and has recently been recommended as the initial treatment for patients with moderately severe eye problems. However, calculations using risk factors presently known reveal a theoretical risk of radiation-induced cancer of 1.2%. Therefore, the authors suggest that this treatment should be reserved for the elderly patient, for example above

  5. Use of corticosteroids to prevent progression of Graves' ophthalmopathy after radioiodine therapy for hyperthyroidism

    Microsoft Academic Search

    Luigi Bartalena; Claudio Marcocci; Fausto Bogazzi; Massimo Panicucci; Antonio Lepri; Aldo Pinchera

    1989-01-01

    We studied the effects of radioiodine treatment of hyperthyroidism due to Graves' disease on Graves' ophthalmopathy and the possible protective role of corticosteroids. Between June 1985 and June 1988, 26 patients were randomly assigned to treatment with radioiodine alone (group 1) and 26 to treatment with this agent and concomitant administration of systemic prednisone for four months (group 2). The

  6. Thyrotropin Receptor Expression in Graves' Orbital Adipose\\/Connective Tissues: Potential Autoantigen in Graves' Ophthalmopathy

    Microsoft Academic Search

    R. S. Bahn; C. M. DUTTON; N. NATT; W. JOBA; C. SPITZWEG; A. E. HEUFELDER

    1998-01-01

    It is acknowledged that the TSH receptor (TSHr) on thyroid fol- licular cells is the autoantigen involved in the hyperthyroidism of Graves' disease. However, whether this receptor is expressed in ex- trathyroidal tissues, and whether it participates directly in the patho- genesis of Graves' ophthalmopathy (GO) are unclear. We sought to detect the expression of TSHr messenger ribonucleic acid (mRNA)

  7. Transconjunctival orbital decompression in Graves' ophthalmopathy: lateral wall approach ab interno

    Microsoft Academic Search

    Dion A Paridaens; Karin Verhoeff; Dimitri Bouwens; Willem A van den Bosch

    2000-01-01

    AIMSA modified surgical technique is described to perform a one, two, or three wall orbital decompression in patients with Graves' ophthalmopathy.METHODSThe lateral wall was approached ab interno through a “swinging eyelid” approach (lateral canthotomy and lower fornix incision) and an extended periosteum incision along the inferior and lateral orbital margin. In addition, the orbital floor and medial wall were removed

  8. Extraocular muscle surgery for Graves' ophthalmopathy: does prior treatment influence surgical outcome?

    Microsoft Academic Search

    M. P. Mourits; L. Koorneef; A. M. van Mourik-Noordenbos; H. M. van der Meulen-Schot; M. F. Prummel; W. M. Wiersinga; A. Berghout

    1990-01-01

    We analysed the results of extraocular muscle surgery in 38 patients with stable Graves' ophthalmopathy. Fixed sutures were used in all patients. A useful field of binocular single vision was achieved in 27 patients (71%) after one operation and in seven patients (18%) after more than one, whereas double vision was persistent in four (11%). No recurrence of diplopia was

  9. Graves' ophthalmopathy: II. Correlation of clinical signs with measures derived from computed tomography

    Microsoft Academic Search

    E S Hallin; S E Feldon

    1988-01-01

    Quantitative clinical and computed tomographic (CT) measures of Graves' ophthalmopathy were obtained in 76 patients. Significant correlation of several CT parameters of the mid-orbital axial CT slice with optic nerve involvement was established. By means of clinical measures, only limitation of ocular motility was found to correlate with the optic neuropathy. The results suggested that there were two distinct populations

  10. Prognostic factors in the radiotherapy of Graves' ophthalmopathy

    SciTech Connect

    Petersen, I.A.; Kriss, J.P.; McDougall, I.R.; Donaldson, S.S. (Stanford Univ. School of Medicine, CA (USA))

    1990-08-01

    Between April 1968 and February 1988, 311 patients with symptomatic and progressive Graves' ophthalmopathy were treated with megavoltage orbital radiotherapy. The patients were divided into three groups: I treated with 20 Gy/2 weeks; II treated with 30 Gy/3 weeks, and III received 20 Gy/2 weeks. The degree of eye involvement was evaluated numerically before and after therapy for each of five parameters: soft tissue signs, proptosis, eye muscle impairment, corneal involvement, and sight loss. Pre-treatment and current thyroid diagnosis and status were also noted. To evaluate the effects of radiotherapy alone, follow-up was terminated at the time any eye surgery was done; for those not treated surgically the minimum follow-up was 12 months. Because there were significant demographic differences between the patient groups, the results of each group were analyzed separately. A stepwise linear regression analysis was performed to determine if there were any significant variables affecting outcome. Based on these data formulae were derived which enable outcome to be predicted in any patient. Before therapy more than 90% of patients in all groups had soft tissue and eye muscle involvement, whereas 65-75% had proptosis and about half 50% had some degree of sight loss. Radiotherapy arrested progression of ophthalmic parameters in all but 1-6% of the patients. Objective and symptomatic improvement was noted for all parameters assessed, but there was marked individual variability. The best responses were noted for soft tissue, corneal involvement, and sight loss; however over half the patients had some improvement in eye muscle function and proptosis. Factors which resulted in less favorable outcome included male gender, advanced age, need for concurrent therapy for hyperthyroidism, and no history of hyperthyroidism. No complications have been observed.

  11. The Tao, psychoanalysis and existential thought.

    PubMed

    Rhee, D

    1990-01-01

    The purpose of this paper is to clarify some existing misunderstandings in the area of psychotherapy, existential approach and the Eastern Tao (Zen Buddhism, Confucianism, Lao-tzu, Chuang-tzu) by showing the common elements between Eastern Tao and psychoanalysis, and existential thought. The author compared the goal of Tao practice, namely, Zen Buddhism, Confucianism etc. with that of Western psychoanalysis, humanistic psychology and transpersonal psychotherapy. He concludes that these goals are the same and that the names are different. He also compared the procedures and processes of psychoanalysis and Zen practice. Sudden enlightenment and gradual training in Zen practice were compared with insight and 'working through' in psychoanalysis. Zen emphasis on relationship, ego strength and interpretation was linked with similar topics in psychoanalysis. The results of Zen practice and the central features of every psychoanalytic treatment were examined and found the same, that is, the resolution of, or transcending of, love (dependence) and hate (hostility). The description of a mature analyst and that of a Boddhisattva were compared and found the same. A trace of neurotic motivation remains but they are not influenced by it in helping others. The problem of theory and reality was discussed and strong emphasis on reality was described; in other words, the goal is directed at reality and theory is only a means pointing at reality. If you see the reality, you should forget the theory. PMID:2290901

  12. Pulsatile ocular blood flow change after treatment with systemic steroid in patients with Graves' ophthalmopathy

    Microsoft Academic Search

    C-C Tsai; H-C Kau; H-H Tsai; S-C Kao; W-M Hsu

    2006-01-01

    PurposeOur previous study has demonstrated an impairment of pulsatile ocular blood flow (POBF) in patients with Graves'ophthalmopathy (GO). Here we further evaluate the haemodynamic change in GO patients after systemic steroid.MethodsIn a prospective, interventional, consecutive clinical case series, all patients with active and moderately severe GO who underwent systemic steroid treatment were evaluated. The change of POBF and the clinical

  13. Lid lengthening by sclera interposition for eyelid retraction in Graves' ophthalmopathy

    Microsoft Academic Search

    M P Mourits; L Koornneef

    1991-01-01

    The efficacy of scleral grafts for eyelid lengthening in patients with thyroid related upper and\\/or lower lid retraction was evaluated in 62 consecutive patients with Graves' ophthalmopathy who underwent lid surgery in the last 3.5 years. Seventy-eight upper and 30 lower lids were lengthened by scleral interposition. A good or acceptable result was achieved in 50% of all operated upper

  14. Cervical lymph nodes, thyroiditis and ophthalmopathy: the pleomorphic face of an immunoglobulin g4-related disease.

    PubMed

    Ghys, Christophe; Depierreux, Michel; Ozalp, Elçin; Velkeniers, Brigitte

    2014-12-01

    We report a case of immunoglobulin G4-related disease (IgG4-RD) presenting with a clinical course suggestive of fibrosing thyroiditis and endocrine ophthalmopathy associated with enlarged cervical lymph nodes. This clinical presentation should prompt a search for associated systemic disorders, including an IgG4-RD. The clue to the exact diagnosis of the underlying disease is histological examination showing an IgG4 plasmatocytic infiltrate in the inflammatory organs involved. PMID:25759802

  15. Cervical Lymph Nodes, Thyroiditis and Ophthalmopathy: The Pleomorphic Face of an Immunoglobulin G4-Related Disease

    PubMed Central

    Ghys, Christophe; Depierreux, Michel; Ozalp, Elçin; Velkeniers, Brigitte

    2014-01-01

    We report a case of immunoglobulin G4-related disease (IgG4-RD) presenting with a clinical course suggestive of fibrosing thyroiditis and endocrine ophthalmopathy associated with enlarged cervical lymph nodes. This clinical presentation should prompt a search for associated systemic disorders, including an IgG4-RD. The clue to the exact diagnosis of the underlying disease is histological examination showing an IgG4 plasmatocytic infiltrate in the inflammatory organs involved. PMID:25759802

  16. Long-term effects of Graves' ophthalmopathy on health-related quality of life

    Microsoft Academic Search

    Caroline Terwee; I. M. M. J. Wakelkamp; H. S. Tan; Friedo Dekker; Mark F Prummel; Wilmar Wiersinga

    2002-01-01

    Objective: Little is known about the long-term effects of Graves' ophthalmopathy (GO) on health- related quality of life (HRQL) after the eye treatment is considered to be finished. The aim of this study was to quantify these effects using validated HRQL questionnaires. Design: A cross-sectional follow-up study was carried out in GO patients who had started radiotherapy and\\/or prednisone treatment

  17. Randomized double-blind trial of prednisone versus radiotherapy in Graves' ophthalmopathy

    SciTech Connect

    Prummel, M.F.; Mourits, M.; Blank, L.; Berghout, A.; Koornneef, L.; Wiersinga, W.M. (Univ. of Amsterdam (Netherlands))

    1993-10-16

    Corticosteriods are usually given for management of Graves' ophthalmopathy, but they have many and serious side-effects. By comparison, retrobulbar irradiation is well tolerated, although its efficacy has been evaluated only in uncontrolled studies. Therefore, the authors did a double-blind randomized trial, in which 28 patients with moderately severe Graves' ophthalmopathy were treated with a 3-month course of oral prednisone and sham irradiation, and 28 received retrobulbar irradiation (20 Gy) and placebo capsules. Therapeutic outcome, assessed twenty-four weeks after the start of treatment, was determined by the change in the highest NOSPECS class. A successful outcome was observed in 14 prednisone-treated and in 13 irradiated patients. Responders to treatment (but not nonresponders) in both groups showed improvements in total and subjective eye score and a decrease in eye-muscle volume. Response to either treatment was due largely to changes in soft-tissue involvement and eye-muscle motility. Radiotherapy and oral prednisone appear to be equally effective as initial treatment in patients with moderately severe Graves' ophthalmopathy. In view of its better tolerability, radiotherapy should be considered the treatment of first choice.

  18. Hanz Tao, PT, DPT Office Address: Student Health Services

    E-print Network

    Tullos, Desiree

    Hanz Tao, PT, DPT Office Address: Student Health Services SHS @ Dixon Recreation Center Corvallis since 2013 Educational Background Doctor of Physical Therapy, University of Colorado, Aurora, CO, 2013 therapy Chronic pain Professional Membership and Involvement American Physical Therapy Association (APTA

  19. TRUTH AND ACTION OSMOSIS (THE TAO COMPUTATION MODEL)

    E-print Network

    Vasconcelos, Vasco Thudichum

    TRUTH AND ACTION OSMOSIS (THE TAO COMPUTATION MODEL) ANT â?? ONIO PORTO, VASCO T. VASCONCELOS by the database. Commands always execute and as an e#ect may change the database. We thus have the osmosis

  20. A TECHNICAL SURVEY OF HARMONIC ANALYSIS TERENCE TAO

    E-print Network

    Tao, Terence

    A TECHNICAL SURVEY OF HARMONIC ANALYSIS TERENCE TAO-variable harmonic analysis, and some of the techni* *ques being developed. Note: references are completely broadly speaking, harmonic analysis is centered around the analysis (in pa* *r- ticular, quantitative

  1. TROPICAL ATMOSPHERE-OCEAN (TAO) PROGRAM FINAL CRUISE REPORT

    E-print Network

    /NDBC Alan Lossett M US NOAA/NDBC James Coleman M US NOAA/NDBC 2.0 OPERATIONS 2.1 TAO Data Recovery Summary: James Haden. Participating Scientists: Name Gender Nationality Affiliation James Haden M US NOAA

  2. The incidence of ophthalmopathy after radioiodine therapy for Graves` disease: Prognostic factors and the role of methimazole

    Microsoft Academic Search

    A. W. C. Kung; A. Cheng

    1994-01-01

    Radioactive iodine-131 (RAI) has been reported to be associated with a high incidence of development or exacerbation of Graves` ophthalmopathy (GO). This is thought to be associated with a surge of autoantibodies after RAI therapy. The role of methimazole (MMI), which possesses immunomodulatory action, in the prevention of GO was explored by studying 114 patients with Graves` disease. They were

  3. Assessment of a carcinogenic risk for treatment of Graves’ ophthalmopathy in dependence on age and irradiation geometry

    Microsoft Academic Search

    J. J. Broerse; A. Snijders-Keilholz; J. Th. M. Jansen; J. Zoetelief; C. Klein; M. H. Seegenschmiedt

    1999-01-01

    In view of the probable carcinogenic risk due to the irradiation of Graves’ ophthalmopathy in young patients the effective dose was assessed for two geometries. Adjusting the field to the conical outline of the orbit resulted in appreciable reduction in dose to uninvolved areas such as brain and bone marrow. In Leiden and in Essen the initial target dose was

  4. Upper Eyelid Retraction in the Absence of Other Evidence for Progressive Ophthalmopathy is Associated with Eye Muscle Autoantibodies

    Microsoft Academic Search

    Mario Salvi; Debbie Scalise; Carol Stolarski; Bryan Arthurs; Susan Lindley; Jack Kennerdell; Jack R. Wall

    1995-01-01

    We have studied 25 clinically euthyroid patients with eyelid lag and retraction referred to thyroid\\/eye clinic for clinical and orbital imaging evidence of extraocular eye muscle (EM) involvement, evidence of progressive ophthalmopathy and serum antibodies reactive with EM membrane antigens in immunoblotting. Fourteen patients had Graves' hyperthyroidism, 5 had Hashimoto's thyroiditis, and 6 had euthyroid Graves' disease. By carrying out

  5. Protracted Hypofractionated Radiotherapy for Graves' Ophthalmopathy: A Pilot Study of Clinical and Radiologic Response

    SciTech Connect

    Casimiro de Deus Cardoso, Cejana; Giordani, Adelmo Jose [Department of Clinical and Experimental Oncology, Division of Radiotherapy, Federal University of Sao Paulo, Sao Paulo, SP (Brazil); Borri Wolosker, Angela Maria [Department of Radiology, Federal University of Sao Paulo, Sao Paulo, SP (Brazil); Souhami, Luis [Department of Radiotherapy, McGill University Heath Centre, Montreal, Quebec (Canada); Gois Manso, Paulo [Department of Ophthalmology, Federal University of Sao Paulo, Sao Paulo, SP (Brazil); Souza Dias, Rodrigo; Comodo Segreto, Helena Regina [Department of Clinical and Experimental Oncology, Division of Radiotherapy, Federal University of Sao Paulo, Sao Paulo, SP (Brazil); Araujo Segreto, Roberto, E-mail: segreto.dmed@epm.br [Department of Clinical and Experimental Oncology, Division of Radiotherapy, Federal University of Sao Paulo, Sao Paulo, SP (Brazil)

    2012-03-01

    Purpose: To evaluate the clinical and radiologic response of patients with Graves' ophthalmopathy given low-dose orbital radiotherapy (RT) with a protracted fractionation. Methods and Materials: Eighteen patients (36 orbits) received orbital RT with a total dose of 10 Gy, fractionated in 1 Gy once a week over 10 weeks. Of these, 9 patients received steroid therapy as well. Patients were evaluated clinically and radiologically at 6 months after treatment. Clinical response assessment was carried out using three criteria: by physical examination, by a modified clinical activity score, and by a verbal questionnaire considering the 10 most common signs and symptoms of the disease. Radiologic response was assessed by magnetic resonance imaging. Results: Improvement in ocular pain, palpebral edema, visual acuity, and ocular motility was observed in all patients. Significant decrease in symptoms such as tearing (p < 0.001) diplopia (p = 0.008), conjunctival hyperemia (p = 0.002), and ocular grittiness (p = 0.031) also occurred. Magnetic resonance imaging showed decrease in ocular muscle thickness and in the intensity of the T2 sequence signal in the majority of patients. Treatments were well tolerated, and to date no complications from treatment have been observed. There was no statistical difference in clinical and radiologic response between patients receiving RT alone and those receiving RT plus steroid therapy. Conclusion: RT delivered in at a low dose and in a protracted scheme should be considered as a useful therapeutic option for patients with Graves' ophthalmopathy.

  6. Thyroid-stimulating immunoglobulins as measured in a reporter bioassay are not detected in patients with Hashimoto’s thyroiditis and ophthalmopathy or isolated upper eyelid retraction

    PubMed Central

    Wall, Jack R; Lahooti, Hooshang; El Kochairi, Ilhem; Lytton, Simon D; Champion, Bernard

    2014-01-01

    Although ophthalmopathy is mainly associated with Graves’ hyperthyroidism, milder eye changes are also found in about 25% of patients with Hashimoto’s thyroiditis (HT). The recent finding of negative thyrotropin receptor (TSHR) antibodies, as measured in the Thyretain™ thyroid-stimulating immunoglobulin (TSI) reporter bioassay, in patients with euthyroid Graves’ disease raises the possibility that TSHR antibodies are not the cause of ophthalmopathy in all situations. Here, we have tested serum from patients with HT with and without ophthalmopathy or isolated upper eyelid retraction (UER) for TSHR antibodies, using the TSI reporter bioassay and collagen XIII as a marker of autoimmunity against the orbital fibroblast. Study groups were 23 patients with HT with ophthalmopathy, isolated UER, or both eye features and 17 patients without eye signs. Thyretain™ TSI results were expressed as a percentage of the sample-to-reference ratio, with a positive test being taken as a sample-to-reference ratio of more than 140%. Serum collagen XIII antibodies were measured in standard enzyme-linked immunosorbent assay. TSI tests were positive in 22% of patients with HT with no eye signs but in no patient with eye signs. In contrast, TSI tests were positive in 94% of patients with Graves’ ophthalmopathy. Tests were negative in all normal subjects tested. Collagen XIII antibodies were detected in 83% of patients with ophthalmopathy, UER, or both eye features, but in only 30% of patients with no eye signs. Our findings suggest that TSHR antibodies do not play a major role in the pathogenesis of ophthalmopathy or isolated UER in patients with HT. Moreover, the role of TSHR antibodies in the development of ophthalmopathy in patients with Graves’ disease remains to be proven. In contrast, collagen XIII antibodies appear to be a good marker of eye disease in patients with HT. PMID:25336908

  7. Interpretation and validity of changes in scores on the Graves' ophthalmopathy quality of life questionaire (GO-QOL) after different treatments

    Microsoft Academic Search

    C. B. Terwee; F. W. Dekker; M. P. Mourits; M. N. Gerding; L. Baldeschi; R. Kalmann; M. F. Prummel; W. M. Wiersinga

    2001-01-01

    Summary OBJECTIVE The Graves' ophthalmopathy quality of life questionnaire (GO-QOL) is the first instrument available to measure health-related quality of life (HRQL) of patients with Graves' ophthalmopathy. The main objective of this study was to define a minimal clinically important difference (MCID) in score on the GO-QOL that can be considered an important improvement in HRQL by examining changes in

  8. Autonomous Trust Establishment1 Tao Jiang John S. Baras

    E-print Network

    Baras, John S.

    of nodes and parameters that speed up or slow down this transition. keywords: Network, Trust EstablishmentAutonomous Trust Establishment1 Tao Jiang John S. Baras Institute for Systems Research}@isr.umd.edu Abstract Trust establishment in networks is the essential foundation for follow-on security mecha- nisms

  9. TROPICAL ATMOSPHERE-OCEAN (TAO) PROGRAM FINAL CRUISE REPORT

    E-print Network

    Ka'imimoana and other ships. The buoys' deployment lifecycle are up to 18 months to ensure at least-688-7465 Email: shannon.mcarthur@noaa.gov Email: lex.leblanc@noaa.gov #12;TAO Cruise Objective and Planm Mooring Operation: Recovery Mooring ID#: PM768B Deployed Location: 08 02.9N 165 08.5E Deployed

  10. COMPRESSIVE IMAGE FUSION Tao Wan Nishan Canagarajah Alin Achim

    E-print Network

    COMPRESSIVE IMAGE FUSION Tao Wan Nishan Canagarajah Alin Achim Department of Electrical their performance on CS reconstruction. We then propose a new image fusion algorithm in the compressive domain by using an improved sampling pattern. There are few studies regarding the applicability of CS to image

  11. A TECHNICAL SURVEY OF HARMONIC ANALYSIS TERENCE TAO

    E-print Network

    Tao, Terence

    A TECHNICAL SURVEY OF HARMONIC ANALYSIS TERENCE TAO Abstract. A rather technical description of some of the active areas of re- search in modern real-variable harmonic analysis, and some overview Very broadly speaking, harmonic analysis is centered around the analysis (in par- ticular

  12. Modelling Electrical Car Diffusion Based on Agent Tao Zhang, 3

    E-print Network

    Aickelin, Uwe

    Modelling Electrical Car Diffusion Based on Agent 1 Lei Yu, ,2 Tao Zhang, 3 Siebers Peer-Ola, 4 to include things like car parking charges, price of electrical car, energy awareness and word of mouth parking rates and other incentives on the uptake of electrical cars. The goal of this case study

  13. Development of a disease specific quality of life questionnaire for patients with Graves’ ophthalmopathy: the GO-QOL

    Microsoft Academic Search

    Caroline B Terwee; Martin N Gerding; Friedo W Dekker; Mark F Prummel; Wilmar M Wiersinga

    1998-01-01

    AIMTo develop a reliable and valid disease specific quality of life questionnaire (the GO-QOL) for patients with Graves’ ophthalmopathy (GO), that can be used to describe the health related quality of life and changes in health related quality of life over time as a consequence of disease and treatment.METHODS70 consecutive GO patients (age >18 years) who were referred for the

  14. Somatostatin receptor gene expression and inhibitory effects of octreotide on primary cultures of orbital fibroblasts from Graves' ophthalmopathy

    Microsoft Academic Search

    D Pasquali; P Vassallo; D Esposito; A Bellastella; A A Sinisi

    2000-01-01

    To explore the mechanism underlying the effects of the somatostatin (SST) analogue octreotide in Graves' ophthalmopathy (GO), we investigated the expression of SST and of SST receptor (sst1-5) genes in primary cultures of fibroblasts established from retroorbital tissue of GO patients and of control subjects. We determined also SST specific binding sites by competitive binding of (125I- Tyr11)SST-14 and the

  15. Prof. Andrea Tao (left), Dr. Fariba Farhoo, DARPA YFA Program Manager Andrea Tao, assistant professor of NanoEngineering, was recently awarded a 2014 Young Faculty Award

    E-print Network

    Dey, Sujit

    Prof. Andrea Tao (left), Dr. Fariba Farhoo, DARPA YFA Program Manager Andrea Tao, assistant Advanced Research Projects Agency (DARPA) for her research project, "Plasmonic Nanoprobes for Neuronal Monitoring." According to DARPA, "The objective of the DARPA Young Faculty Award (YFA) program is to identify

  16. TAO - A Versatile and Open Platform for Technology-Based Assessment

    Microsoft Academic Search

    Eric Ras; Judith Swietlik; Patrick Plichart; Thibaud Latour

    2010-01-01

    \\u000a The TAO framework is an open-source project that provides a very general and open architecture for developing and delivering\\u000a tests for the purpose of technology-based assessments. Besides summarizing the main features of TAO, this paper lists TAO’s\\u000a advantages compared to other tools and platforms for technology-based assessment, and reports on its capability for integration\\u000a into highly flexible learning environments.

  17. THE TAOS PROJECT: RESULTS FROM SEVEN YEARS OF SURVEY DATA

    SciTech Connect

    Zhang, Z.-W.; Lehner, M. J.; Wang, J.-H.; Wen, C.-Y.; Wang, S.-Y.; King, S.-K.; Cook, K. H.; Lee, T. [Institute of Astronomy and Astrophysics, Academia Sinica. 11F of Astronomy-Mathematics Building, National Taiwan University. No. 1, Sec. 4, Roosevelt Road, Taipei 10617, Taiwan (China); Granados, A. P. [Instituto de Astronomia, Universidad Nacional Autonoma de Mexico, Apdo. Postal 106, Ensenada, Baja California 22800 (Mexico); Alcock, C.; Protopapas, P. [Harvard-Smithsonian Center for Astrophysics, 60 Garden Street, Cambridge, MA 02138 (United States); Axelrod, T. [Steward Observatory, 933 North Cherry Avenue, Room No. 204, Tucson AZ 85721 (United States); Bianco, F. B. [Center for Cosmology and Particle Physics, New York University, 4 Washington Place, New York, NY 10003 (United States); Byun, Y.-I. [Department of Astronomy and University Observatory, Yonsei University, 134 Shinchon, Seoul 120-749 (Korea, Republic of); Chen, W. P. [Institute of Astronomy, National Central University, No. 300, Jhongda Road, Jhongli City, Taoyuan County 320, Taiwan (China); Coehlo, N. K. [Department of Statistics, University of California Berkeley, 367 Evans Hall, Berkeley, CA 94720 (United States); De Pater, I. [Department of Astronomy, University of California Berkeley, 601 Campbell Hall, Berkeley, CA 94720 (United States); Kim, D.-W. [Max Planck Institute for Astronomy, Koenigstuhl 17, D-69117 Heidelberg (Germany); Lissauer, J. J. [Space Science and Astrobiology Division 245-3, NASA Ames Research Center, Moffett Field, CA 94035 (United States); Marshall, S. L., E-mail: zwzhang@asiaa.sinica.edu.tw [Kavli Institute for Particle Astrophysics and Cosmology, 2575 Sand Hill Road, MS 29, Menlo Park, CA 94025 (United States); and others

    2013-07-01

    The Taiwanese-American Occultation Survey (TAOS) aims to detect serendipitous occultations of stars by small ({approx}1 km diameter) objects in the Kuiper Belt and beyond. Such events are very rare (<10{sup -3} events per star per year) and short in duration ({approx}200 ms), so many stars must be monitored at a high readout cadence. TAOS monitors typically {approx}500 stars simultaneously at a 5 Hz readout cadence with four telescopes located at Lulin Observatory in central Taiwan. In this paper, we report the results of the search for small Kuiper Belt objects (KBOs) in seven years of data. No occultation events were found, resulting in a 95% c.l. upper limit on the slope of the faint end of the KBO size distribution of q = 3.34-3.82, depending on the surface density at the break in the size distribution at a diameter of about 90 km.

  18. The sterile 20-like kinase Tao-1 controls tissue growth by regulating the Salvador-Warts-Hippo pathway.

    PubMed

    Poon, Carole L C; Lin, Jane I; Zhang, Xiaomeng; Harvey, Kieran F

    2011-11-15

    The Salvador-Warts-Hippo (SWH) pathway is a complex signaling network that controls both developmental and regenerative tissue growth. Using a genetic screen in Drosophila melanogaster, we identified the sterile 20-like kinase, Tao-1, as an SWH pathway member. Tao-1 controls various biological phenomena, including microtubule dynamics, animal behavior, and brain development. Here we describe a role for Tao-1 as a regulator of epithelial tissue growth that modulates activity of the core SWH pathway kinase cassette. Tao-1 functions together with Hippo to activate Warts-mediated repression of Yorkie. Tao-1's ability to control SWH pathway activity is evolutionarily conserved because human TAO1 can suppress activity of the Yorkie ortholog, YAP. Human TAO1 controls SWH pathway activity by phosphorylating, and activating, the Hippo ortholog, MST2. Given that SWH pathway activity is subverted in many human cancers, our findings identify human TAO kinases as potential tumor suppressor genes. PMID:22075148

  19. Increased response to oxidative stress challenge in Graves’ ophthalmopathy orbital fibroblasts

    PubMed Central

    Tsai, Chieh-Chih; Wu, Shi-Bei; Cheng, Ching-Yu; Kao, Shu-Ching; Kau, Hui-Chuan; Lee, Shui-Mei

    2011-01-01

    Purpose To investigate whether orbital fibroblasts from patients with Graves’ ophthalmopathy (GO) are more responsive to oxidative stress. Methods Lipid peroxidation, oxidative DNA damage, reactive oxygen species (ROS) contents and activities of antioxidant enzymes were measured in cultured orbital fibroblasts from GO patients and age-matched normal controls in response to 200 ?M hydrogen peroxide (H2O2). Results GO fibroblasts had increased basal levels of malondialdehyde (MDA), 8-hydroxy 2'-deoxyguanosine, superoxide anions, H2O2, and manganese-dependent superoxide dismutase (Mn-SOD) activity, as well as decreased glutathione peroxidase (GPx) activity and the ratio between reduced (GSH) and oxidized glutathione (GSSG) compared with the orbital fibroblasts from normal subjects. After treatment of the cells with 200 ?M H2O2, the amplitude of increase in the intracellular levels of MDA (63% versus 26%), H2O2 (24% versus 13%) and Mn-SOD activity (48% versus 23%) was exaggerated in GO fibroblasts compared with normal controls, respectively. In addition, treatment of GO fibroblasts with 200 ?M H2O2 led to a dramatic reduction of catalase activity (?59% versus ?29%), GPx activity (?56% versus ?13%), and GSH/GSSG ratio (?49% versus ?21%), respectively. Conclusions Elevated ROS and redox imbalance in GO orbital fibroblasts were exacerbated by H2O2 as a result of exhaustion of GSH and compromise of antioxidant enzymes. Hypersensitivity to oxidative stress of GO orbital fibroblasts may play a role in the pathogenesis of GO. PMID:22065933

  20. Post-radioiodine De Novo Onset Graves' Ophthalmopathy: Case Reports and a Review of the Literature.

    PubMed

    Batra, Ruchika; Krishnasamy, Senthil Kumar; Buch, Harit; Sandramouli, Soupramanien

    2015-05-01

    New-onset Graves' ophthalmopathy (GO) following radioiodine treatment (RAI) and worsening of existing GO are well-described in the endocrinology literature. These phenomena are recognized by ophthalmologists, yet poorly documented in the ophthalmology literature. Two male patients, aged 43 and 62 years, respectively, with Graves' disease without GO, received RAI. Four months later, one patient developed acute GO with unilateral reduction in visual acuity, conjunctival chemosis, lagophthalmos, bilateral severely restricted ocular motility, and lid retraction. High-dose intravenous steroids, followed by oral steroids, led to a dramatic clinical improvement. The second patient received a second dose of RAI for persistent hyperthyroidism and subsequently developed acute GO-comprising restricted ocular motility, peri-orbital swelling, and conjunctival chemosis. Symptoms gradually resolved on continued carbimazole treatment. Neither patient received pre-RAI prophylactic glucocorticoids, as currently they are only recommended for patients with pre-existing GO or multiple risk factors. We discuss the limitations of using this risk-based approach in preventing new-onset GO following RAI therapy. PMID:24409943

  1. In 2006, Terence Tao was awarded the Fields Medal (the mathematical equivalent of the Nobel Prize).

    E-print Network

    Vakil, Ravi

    In 2006, Terence Tao was awarded the Fields Medal (the mathematical equivalent of the Nobel Prize). Among his other awards are the Bôcher Prize, the SASTRA Ramanujan Prize, the Clay Research Award, the Nemmers Prize, and, in 2010, he shared the PÓlya Prize. Terence TaoJames and Carol Collins Chair

  2. Parallel Performance Studies for a Maximum Likelihood Estimation Problem Using TAO

    E-print Network

    Gobbert, Matthias K.

    in the setting of natural language processing. Using TAO to conduct maximum entropy estimation, he shows using the Toolkit for Advanced Optimization (TAO) software library. The computations are performed sizes vary, and demonstrate that scaling the number of processes for larger problems decreases wall

  3. Audiomagnetotelluric data, Taos Plateau Volcanic Field, New Mexico

    USGS Publications Warehouse

    Ailes, Chad E.; Rodriguez, Brian D.

    2011-01-01

    The U.S. Geological Survey is conducting a series of multidisciplinary studies of the San Luis Basin as part of the Geologic framework of the Rio Grande Basins project. Detailed geologic mapping, high-resolution airborne magnetic surveys, gravity surveys, audiomagnetotelluric surveys, and hydrologic and lithologic data are being used to better understand the aquifers. This report describes a regional east-west audiomagnetotelluric sounding profile acquired in late July 2009 across the Taos Plateau Volcanic Field. No interpretation of the data is included.

  4. Pliocene Volcanic Evolution of the Taos Plateau, New Mexico

    NASA Astrophysics Data System (ADS)

    Cosca, M. A.; Thompson, R. A.; Turner, K. J.; Lee, J. P.

    2012-12-01

    New geologic mapping (1:24k-1:50k scale) and high precision 40Ar/39Ar geochronology of volcanic rocks from the Taos Plateau in northern New Mexico reveals nearly 4 million years of predominantly mafic (basalt to andesite) volcanism associated with the Pliocene to Quaternary Rio Grande rift. A nearly continuous record of volcanism is recorded from ~5 to ~1 Ma with two major pulses of magmatism observed at ~4.5 Ma and ~3 Ma reflecting eruption from more than 50 mapped centers and an unresolved number of centers buried by intercalated rift volcanics and sedimentary basin fill. Volcanism, both outflow thickness and vent locations, is strongly controlled by the same north to northwest trending fault systems defining the Rio Grande rift graben. However, active loci of volcanism can be linked to sub-basins within the broader graben structure. Large composite volcanoes ranging in composition from basaltic andesite to andesite, such as Guadeloupe Mountain (~4.5-5 Ma), Ute Mountain (~3.9 Ma), and San Antonio Mountain (~3 Ma) formed over time intervals of about 300 ka during the most voluminous stages of activity. Similar time intervals are recorded in each of three Servilleta basalt flow packages (lower (~4.5 Ma), middle (~4 Ma), and upper (~3.5 Ma)) observed at the Rio Grande gorge just north of Taos that first began erupting at ~ 4.7 Ma. Distinctive reddish paleosols between each Servilleta flow package represent time intervals between eruptions of ~0.5 Ma. Late stage volcanic activity (< 3 Ma) is recorded as small volume Servilleta basalt volcanoes and numerous small basalt to basaltic andesite cinder cones and associated lavas flows. Mesita Cone, dated at ~ 1 Ma and offset by middle Pleistocene faulting, represents the youngest volcanic activity within the Taos plateau segment of the Rio Grande Rift. The Pliocene to Quaternary volcanic rocks of the Taos Plateau are locally underlain by 1) Precambrian crystalline granite basement, 2) Oligocene calc-alkaline volcanic and associated intrusive rocks of the southern Rocky Mountain volcanic field, 3) a mafic to intermediate composition Miocene volcanic platform in the northern part of the plateau, or 4) Miocene to Quaternary basin-fill deposits in actively subsiding extensional sub-basins of the eastern plateau. The stratigraphic relationship of this Pliocene volcanism to the earlier igneous activity, mapped faults, and erosional unconformities establishes temporal constraints on regional extension prior to Pliocene rifting. Preliminary 40Ar/39Ar results and integrated mapping support an interpretation of contemporaneous rift sub-basin development and Pliocene volcanism as the primary manifestation of continental rifting vs. regional extension in northern New Mexico.

  5. Molecular cloning and characterization of genes for antibodies generated by orbital tissue-infiltrating B-cells in Graves` ophthalmopathy

    SciTech Connect

    Jaume, J.C.; Portolano, S.; Prummel, M.F.; McLachlan, S.M.; Rapoport, B. [Univ. of California, San Francisco, CA (United States)] [Univ. of California, San Francisco, CA (United States)

    1994-02-01

    Graves` ophthalmopathy is a distressing autoimmune disease of unknown etiology. Analysis of the genes for antibodies secreted by orbital tissue-infiltrating plasma cells might provide insight into the pathogenesis of this disease. The authors, therefore, constructed an immunoglobulin heavy (H) chain and an immunoglobulin k light (L) chain cDNA library from the orbital tissue of a patient with active Graves` ophthalmopathy. Analysis of 15 H (IgG1) and 15 L (k) chains revealed a restricted spectrum of variable region genes. Fourteen of 15 variable k genes were about 94% homologous to the closest known germline gene, KL012. Thirteen of 15 H chain genes were 91% and 90% homologous to the closest germline genes, DP10 and hv1263, respectively. Remarkably, these germline genes also code for other autoantibodies to striated muscle (KL012) and thyroid peridase (KL012 and hv1263). These studies raise the possibility that particular germline genes may be associated with autoimmunity in humans. Further, the present study opens the way to identifying ocular autoantigens that may be the target of an humoral immune response. 29 refs., 4 figs., 1 tab.

  6. 2013 European thyroid association guidelines for cervical ultrasound scan and ultrasound-guided techniques in the postoperative management of patients with thyroid cancer.

    PubMed

    Leenhardt, L; Erdogan, M F; Hegedus, L; Mandel, S J; Paschke, R; Rago, T; Russ, G

    2013-09-01

    Cervical ultrasound scanning (US) is considered a key examination, by all major thyroid and endocrine specialist societies for the postoperative follow-up of thyroid cancer patients to assess the risk of recurrence. Neck US imaging is readily available, non-invasive, relatively easy to perform, cost-effective, and can guide diagnostic and therapeutic procedures with low complication rates. Its main shortcoming is its operator-dependency. Because of the pivotal role of US in the care of thyroid cancer patients, the European Thyroid Association convened a panel of international experts to review technical aspects, indications, results, and limitations of cervical US in the initial staging and follow-up of thyroid cancer patients. The main aim is to establish guidelines for both a cervical US scanning protocol and US-guided diagnostic and therapeutic procedures in patients with thyroid cancer. This report presents (1) standardization of the US scanning procedure, techniques of US-guided fine-needle aspiration, and reporting of findings; (2) definition of criteria for classification of malignancy risk based on cervical US imaging characteristics of neck masses and lymph nodes; (3) indications for US-guided fine-needle aspiration and for biological in situ assessments; (4) proposal of an algorithm for the follow-up of thyroid cancer patients based on risk stratification following histopathological and cervical US findings, and (5) discussion of the potential use of US-guided localization and ablation techniques for locoregional thyroid metastases. PMID:24847448

  7. Orbital positron emission tomography/computed tomography (PET/CT) imaging findings in graves ophthalmopathy

    PubMed Central

    2013-01-01

    Background We aimed to describe orbital positron emission tomography/computed tomography (PET/CT) imaging findings, both structural and metabolic, in different clinical stages of Graves ophthalmopathy (GO). This prospective, observational, cross-sectional study examined 32 eyes of 16 patients with GO. Methods Patients were assessed with a complete ophthalmological evaluation and assigned a VISA classification for GO. All patients underwent serum thyroid hormone measurement, antibody profile, and 18-fluorodeoxyglucose positron emission tomography/computed tomography (18-FDG PET/CT) of the orbits. The 18-FDG uptake on PET images was expressed in terms of maximum standard uptake value (SUVmax). CT images were analyzed, and orbital structures were measured in millimeters. Vision, inflammation, strabismus, and overall appearance were assessed according to the VISA classification system, thyroid hormone levels, antibody values, 18-FDG uptake, and thickness of orbital structures. Results Altogether, 32 eyes of 16 patients (10 women, 6 men; mean age 44.31?±?13 years, range 20–71 years) were included. Three patients were hypothyroid, seven were euthyroid, and six were hyperthyroid. CT measurements of extraocular muscle diameter were elevated (P??0.05). Conclusions We demonstrated a lack of correlation between 18-FDG extraocular muscle uptake and either clinical inflammation score or muscle diameter. Although 18-FDG uptake has been used as an inflammation marker in other pathologies, inflammation in GO may be clinically detected in PET/CT-negative cases, and cases with negative clinical findings may show inflammation on PET/CT. Clinical evaluation is mandatory but may be insufficient and inaccurate for classifying GO. A larger and homogeneous sample size and further research is needed to define the role of PET/CT in detecting, grading, and follow-up of GO to optimize treatment of the inflammatory stage respect clinical methods currently used. PMID:24007404

  8. Circulating microRNA predicts insensitivity to glucocorticoid therapy in Graves' ophthalmopathy.

    PubMed

    Shen, Liyun; Huang, Fengjiao; Ye, Lei; Zhu, Wei; Zhang, Xiaofang; Wang, Shu; Wang, Weiqing; Ning, Guang

    2015-06-01

    Glucocorticoid (GC) insensitivity occurs commonly in Graves' ophthalmopathy (GO), and GC therapy is associated with major adverse effects. A reliable and easily accessible biomarker is required to predict the outcome of GC therapy. This study aimed to evaluate the performance of circulating microRNA (miRNA) to predict GC insensitivity in GO patients. A total of 35 consecutive patients were included in this study. A cumulative dose of 4.5 g of methylprednisolone (MP) was administered intravenously for 12 weeks. Pretreatment serum miRNAs from the best- (N = 5) and worst- (N = 4) responding patients were profiled using miScript PCR arrays and validated by quantitative PCR in all patients. We calculated the predictive value of pretreatment assays of serum miRNAs with regard to GC insensitivity. We further investigated the roles of target miRNAs in modulating NF-?B activity and restoring transrepression of an NF-?B reporter by dexamethasone. Nine miRNAs displayed significant differences between responsive and resistant patients by miScript PCR arrays. Validation of the top two miRNAs in all 35 patients confirmed a significantly lower serum level of miR-224-5p (p = 0.0048) in resistant patients. A multivariate logistic regression model identified a composite biomarker combining baseline serum miR-224-5p and TRAb was independently associated with GC response (OR: 2.565, 95 % CI 1.011-6.505, p = 0.047). Receiver operating characteristic (ROC) curves analysis revealed the composite marker combining miR-224-5p and TRAb led to a 91.67 % positive prediction value (PPV) and a 69.56 % negative prediction value (NPV) with regard to GC resistance. Overexpression of miR-224-5p restored transrepression of the NF-?B reporter by dexamethasone under induced resistance, which may be via targeting GSK-3? to increase GR protein level. Our study demonstrated baseline serum miR-224-5p was associated with GC sensitivity in GO and in vitro overexpression of miR-224-5p restored GC sensitivity in a resistant cell model. A parameter combined serum miR-224-5p and TRAb could effectively predict GC sensitivity in GO patients. PMID:25588771

  9. Status of the Transneptunian Automated Occultation Survey (TAOS II)

    NASA Astrophysics Data System (ADS)

    Reyes-Ruiz, Mauricio

    2014-11-01

    TAOS II is a next generation occultation survey with the goal of measuring the size distribution of the small objects (diameters between 0.5 and 30 km) in the Kuiper Belt. The project is a collaboration between the Academia Sinica Institute of Astronomy and Astrophysics, the Universidad Nacional Autonoma de Mexico, and the Harvard-Smithsonian Center for Astrophysics, The survey will operate three 1.3 m telescopes at San Pedro Martir Observatory in Baja California, Mexico. Each telescope will be equipped with a custom camera comprising a focal plane array of CMOS imagers. Each camera will be capable of reading out image data from 10,000 stars at a cadence of 20 Hz. All telescopes will monitor the same set of stars simultaneously to search for coincident occultation events while minimizing the false positive rate. This poster describes the project and reports on the progress of the development of the survey infrastructure.

  10. Development of a new mid-infrared instrument for the TAO 6.5-m Telescope

    Microsoft Academic Search

    Takashi Miyata; Shigeyuki Sako; Tomohiko Nakamura; Kentaro Asano; Mizuho Uchiyama; Takashi Onaka; Itsuki Sakon; Hirokazu Kataza; Yoshifusa Ita; Tsutomu Aoki; Mamoru Doi; Toshihiro Handa; Daisuke Kato; Kimiaki Kawara; Kotaro Kohno; Masahiro Konishi; Shintaro Koshida; Takeo Minezaki; Natsuko Mitani; Kentaro Motohara; Takao Soyano; Toshihiko Tanabe; Masuo Tanaka; Ken'ichi Tarusawa; Yuzuru Yoshii

    2010-01-01

    Ground-based mid-infrared observations have two distinct advantages over space observations despite relatively lower sensitivity. One is the high spatial resolution and the other is the monitoring capability. These advantages can be emphasized particularly for the next coming ground-based infrared project University of Tokyo Atacama Observatory (TAO). Thanks to the low water vapor of the TAO site (5,640m) and the large

  11. The incidence of ophthalmopathy after radioiodine therapy for Graves` disease: Prognostic factors and the role of methimazole

    SciTech Connect

    Kung, A.W.C. [Univ. of Hong Kong, Pokfulam (Hong Kong)] [Univ. of Hong Kong, Pokfulam (Hong Kong); Cheng, A. [Queen Mary Hospital, Pokfulam (Hong Kong)] [Queen Mary Hospital, Pokfulam (Hong Kong)

    1994-08-01

    Radioactive iodine-131 (RAI) has been reported to be associated with a high incidence of development or exacerbation of Graves` ophthalmopathy (GO). This is thought to be associated with a surge of autoantibodies after RAI therapy. The role of methimazole (MMI), which possesses immunomodulatory action, in the prevention of GO was explored by studying 114 patients with Graves` disease. They were assigned randomly to receive either RAI alone or adjunctive antithyroid drugs, which consisted of MMI and L-T{sub 4} as a block-replacement therapy for 12 months and were followed for 2 yr. Thirty-five patients (30.7%) had GO at presentation. Twenty-one (18%) patients developed new GO, and six had worsening of preexisting GO. The development of hypothyroidism (P < 0.01) and an elevation of TSH (P < 0.05) were associated with increased risk of development or exacerbation of GO. The chance of development or exacerbation of GO is higher in those with no ophthalmopathy than in those with preexisting GO at presentation (P = 0.002). The incidence of development or exacerbation of GO was similar in the two treatment groups (RAI, 22.8%; adjunctive antithyroid drugs, 23.7%; P = NS). MMI was able to suppress the surge of TSH receptor antibody (TRAB) after RAI, but a surge in TRAB was not of prognostic significance for the development of GO after RAI. Patients who developed or had exacerbation of GO actually had lower TRAB at presentation (P = 0.02). The authors conclude that hypothyroidism with elevated TSH is an important adverse factor for the development or exacerbation of GO, and MMI was unable to prevent the development or exacerbation of GO after RAI. 35 refs., 4 tabs.

  12. Tao-1 phosphorylates Hippo/MST kinases to regulate the Hippo-Salvador-Warts tumor suppressor pathway.

    PubMed

    Boggiano, Julian C; Vanderzalm, Pamela J; Fehon, Richard G

    2011-11-15

    Recent studies have shown that the Hippo-Salvador-Warts (HSW) pathway restrains tissue growth by phosphorylating and inactivating the oncoprotein Yorkie. How growth-suppressive signals are transduced upstream of Hippo remains unclear. We show that the Sterile 20 family kinase, Tao-1, directly phosphorylates T195 in the Hippo activation loop and that, like other HSW pathway genes, Tao-1 functions to restrict cell proliferation in developing imaginal epithelia. This relationship appears to be evolutionarily conserved, because mammalian Tao-1 similarly affects MST kinases. In S2 cells, Tao-1 mediates the effects of the upstream HSW components Merlin and Expanded, consistent with the idea that Tao-1 functions in tissues to regulate Hippo phosphorylation. These results demonstrate that one family of Ste20 kinases can activate another and identify Tao-1 as a component of the regulatory network controlling HSW pathway signaling, and therefore tissue growth, during development. PMID:22075147

  13. Tao-1 Phosphorylates Hippo/MST kinases to Regulate the Hippo-Salvador-Warts Tumor Suppressor Pathway

    PubMed Central

    Boggiano, Julian C.; Vanderzalm, Pamela J.; Fehon, Richard G.

    2011-01-01

    SUMMARY Recent studies have shown that the Hippo-Salvador-Warts (HSW) pathway restrains tissue growth by phosphorylating and inactivating the oncoprotein Yorkie. How growth suppressive signals are transduced upstream of Hippo remains unclear. We show that the Sterile 20 family kinase, Tao-1, directly phosphorylates T195 in the Hippo activation loop and that, like other HSW pathway genes, Tao-1 functions to restrict cell proliferation in developing imaginal epithelia. This relationship appears to be evolutionarily conserved, because mammalian Tao-1 similarly affects MST kinases. In S2 cells Tao-1 mediates the effects of the upstream HSW components Merlin and Expanded, consistent with the idea that Tao-1 functions in tissues to regulate Hippo phosphorylation. These results demonstrate that one family of Ste20 kinases can activate another and identify Tao-1 as a component of the regulatory network controlling HSW pathway signaling, and therefore tissue growth, during development. PMID:22075147

  14. Association of cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) gene polymorphism and non-genetic factors with Graves' ophthalmopathy in European and Japanese populations

    Microsoft Academic Search

    T Bednarczuk; Yuji Hiromatsu; Tomoka Fukutani; Krystian Jazdzewski; Piotr Miskiewicz; Maria Osikowska; Janusz Nauman

    2003-01-01

    Objective: The development and severity of Graves' ophthalmopathy (GO) may result from a complex interplay of genetic and environmental factors. The aim of this study was to investigate the associ- ation of cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) gene polymorphism and non-genetic factors (age, sex, cigarette smoking) with GO in two different populations, Polish-Caucasians and Japanese. Design: We investigated the distribution of

  15. Fat-removal orbital decompression for disfiguring proptosis associated with Graves' ophthalmopathy: safety, efficacy and predictability of outcomes.

    PubMed

    Li, Emmy Y; Kwok, Tracy Y; Cheng, Andy C; Wong, Alex C; Yuen, Hunter K

    2015-06-01

    The objective of this study was to analyse clinical outcomes of patient who underwent fat-removal orbital decompression (FROD) for disfiguring proptosis associated with Graves' ophthalmopathy. This is a retrospective review of 21 eyes of 11 patients who have received transforniceal FROD for disfiguring Graves' exophthalmos at the Hong Kong Eye Hospital from January 2009 to March 2012. The amount of orbital fat removed and proptosis reduction in terms of Hertel value and complications were evaluated. The mean volume of orbital fat removed was 4.0 ± 1.1 ml (range 1.6-5.5 ml), and the mean change of Hertel value was 4.2 ± 1.3 (range 1-6, p < 0.000). None has visual loss or new-onset diplopia at primary gaze after FROD. No complications such as retrobulbar haemorrhage, meningitis, sinusitis, tissue necrosis, infraorbital paraesthesia or unsightly scar were observed. FROD could achieve reasonable proptosis reduction. It had a good safety profile, and results were predictable. PMID:24777241

  16. Circulating levels of miR-146a and IL-17 are significantly correlated with the clinical activity of Graves' ophthalmopathy.

    PubMed

    Wei, Hongfa; Guan, Meiping; Qin, Yan; Xie, Cuihua; Fu, Xiajun; Gao, Fang; Xue, Yaoming

    2014-11-28

    Graves' ophthalmopathy (GO) is a common autoimmune disease that is difficult to deal with due to limited clinical evaluation methods. Recently miR-146a and Interleukin-17 (IL-17) have been found to be involved in autoimmune disorders and correlated with disease activity. However, it is unclear whether they are involved in Graves' ophthalmopathy (GO). The aim of this study is to investigate the correlation of circulating levels of miR-146a and IL-17 with clinical activity in GO patients. Fifty-seven study subjects were enrolled in four groups according to the corresponding criteria: active-GO, inactive-GO, Graves disease (GD) without ophthalmopathy, and healthy control group. The circulating levels of miR-146a and IL-17 were determined by qRT-PCR and ELISA, respectively. Serum IL-17 levels of GD, inactive-GO, and active-GO groups were all significantly higher than that of control (all P < 0.001). Active-GO group had significantly higher IL-17 level than inactive-GO and GD groups (P = 0.024 and P = 0.001, respectively). Active-GO and inactive-GO group had significantly lower miR-146a expressions than control (P < 0.05). Active-GO group had significantly lower miR-146a than inactive-GO group (P < 0.05). Serum levels of IL-17 and miR-146a were both significantly correlated with clinical activity score (CAS) in GO patients (P < 0.001, P < 0.001, respectively). There was a significant negative correlation of circulating miR-146a expression with serum IL-17 levels (P < 0.01). These findings indicated that circulating levels of miR-146a and IL-17 may be potential biomarkers of active GO, and may play a key role in the progression of GO. PMID:25100151

  17. Wavelet Analysis and Applications Tao Qian, Mang I. Vai and Xu Yuesheng, Eds.

    E-print Network

    Abry, Patrice

    Wavelet Analysis and Applications Tao Qian, Mang I. Vai and Xu Yuesheng, Eds. Applied and Numerical Harmonic Analysis, 219­264 c 2006 Birkh¨auser Verlag Basel/Switzerland Wavelet Leaders in Multifractal multifractal formalisms based on wavelet coefficients are compared from both mathematical and numerical points

  18. Fabrication of magnetic microfiltration systems using soft lithography Tao Deng, Mara Prentiss,a)

    E-print Network

    Prentiss, Mara

    Fabrication of magnetic microfiltration systems using soft lithography Tao Deng, Mara Prentiss the captured material without disassembling the filter by turning off the external magnetic field .7 Magnetic implementation, and it is usually carried out simply by plac- ing a test-tube containing a magnetic material

  19. TCP-Mobile Edge: Accelerating Delivery in Mobile Tao Han and Nirwan Ansari

    E-print Network

    Ansari, Nirwan

    --Owing to the imminent fixed mobile convergence, Internet applications are frequently accessed through mobile nodes. Considering the QoS (Quality of Service) mechanisms of mobile networks, TCP-ME is designed to differentiateTCP-Mobile Edge: Accelerating Delivery in Mobile Networks Tao Han and Nirwan Ansari New Jersey

  20. JBOOMT: Jade Bird Object-Oriented Metrics Tool* Tao XIE, Wanghong YUAN, Hong MEI, Fuqing YANG

    E-print Network

    Xie, Tao

    JBOOMT: Jade Bird Object-Oriented Metrics Tool* Tao XIE, Wanghong YUAN, Hong MEI, Fuqing YANG the metrics model. The objective of Jade Bird Object-Oriented Metrics Tool (JBOOMT) is to provide an automated implementation built in the Jade Bird Program Analysis System (JBPAS). Keyword software metrics, object

  1. Searching the Web Using Composed Pages Ramakrishna Varadarajan Vagelis Hristidis Tao Li

    E-print Network

    Hristidis, Vagelis

    Searching the Web Using Composed Pages Ramakrishna Varadarajan Vagelis Hristidis Tao Li Florida.3 [Information Search and Retrieval] General Terms: Algorithms, Performance Keywords: Composed pages 1. INTRODUCTION Given a user keyword query, current Web search engines return a list of pages ranked

  2. CSC2522 Course Project Michael Tao 6.1 Rendering Wet Sand

    E-print Network

    Toronto, University of

    CSC2522 Course Project Michael Tao 6.1 Rendering Wet Sand 6.1.1 Goals The primary goal of this project was to implement a method for rendering sand as a wet porous medium with water flowing into it from within PBRT. The final result was a video of sand being wetted by water particles flowing through

  3. Optimizing Threaded MPI Execution on SMP Clusters Hong Tang and Tao Yang

    E-print Network

    Yang, Tao

    Optimizing Threaded MPI Execution on SMP Clusters Hong Tang and Tao Yang Department of Computer://www.cs.ucsb.edu/research/TMPI/ ABSTRACT Our previous work has shown that using threads to execute MPI programs can yield great performance of a thread­based MPI system on SMP clusters. Our study indicates that with a proper design for threaded MPI

  4. The TAOS Project Stellar Variability II. Detection of 15 Variable Stars

    SciTech Connect

    Mondal, S; Lin, C C; Zhang, Z W; Alcock, C; Axelrod, T; Bianco, F B; Byun, Y I; Coehlo, N K; Cook, K H; Dave, R; Kim, D W; King, S K; Lee, T; Lehner, M J; Lin, H C; Marshall, S L; Protopapas, P; Rice, J A; Schwamb, M E; Wang, J H; Wang, S Y; Wen, C Y

    2010-01-28

    The Taiwanese-American Occultation Survey (TAOS) project has collected more than a billion photometric measurements since 2005 January. These sky survey data - covering timescales from a fraction of a second to a few hundred days - are a useful source to study stellar variability. A total of 167 star fields, mostly along the ecliptic plane, have been selected for photometric monitoring with the TAOS telescopes. This paper presents our initial analysis of a search for periodic variable stars from the time-series TAOS data on one particular TAOS field, No. 151 (RA = 17{sup h} 30{sup m} 6.67{sup s}, Dec = 27 degrees, 17 minutes, 30 seconds, J2000), which had been observed over 47 epochs in 2005. A total of 81 candidate variables are identified in the 3 square degree field, with magnitudes in the range 8 < R < 16. On the basis of the periodicity and shape of the lightcurves, 32 variables, 18 of which were previously unknown, are classified as RR Lyrae, Cepheid, {delta} Scuti, SX Phonencis, semi-regular and eclipsing binaries.

  5. A NILPOTENT FREIMAN DIMENSION LEMMA EMMANUEL BREUILLARD, BEN GREEN, AND TERENCE TAO

    E-print Network

    Breuillard, Emmanuel

    A NILPOTENT FREIMAN DIMENSION LEMMA EMMANUEL BREUILLARD, BEN GREEN, AND TERENCE TAO Abstract. We only on K. The result can be seen as a nilpotent analogue to Freiman's dimension lemma. 1. Introduction in the fifties for the solution of Hilbert's fifth problem on the structure of locally compact groups. The use

  6. Turtle Geometry in Computer Graphics and Computer Aided Design Ron Goldman, Scott Schaefer, Tao Ju

    E-print Network

    Schaefer, Scott

    Turtle Geometry in Computer Graphics and Computer Aided Design Ron Goldman, Scott Schaefer, Tao Ju@cs.rice.edu, sschaefe@rice.edu, jutao@cs.rice.edu Abstract: LOGO is a programming language incorporating turtle graphics, relaxation methods and subdivision schemes from elementary notions in turtle geometry and turtle programming

  7. Which Faults are Security Faults? Michael Gegick, Tao Xie, Laurie Williams, Pete Rotella

    E-print Network

    Young, R. Michael

    Which Faults are Security Faults? Michael Gegick, Tao Xie, Laurie Williams, Pete Rotella North, williams}@csc.ncsu.edu, protella@cisco.com Abstract The subtleties associated with security faults can sometimes be missed by developers and testers. When developers encounter a fault and are unaware

  8. Giving Meanings to WWW Images Heng Tao Shen Beng Chin Ooi Kian-Lee Tan

    E-print Network

    Ooi, Beng Chin

    Giving Meanings to WWW Images Heng Tao Shen Beng Chin Ooi Kian-Lee Tan Department of Computer Science National University of Singapore 3 Science Drive 2, Singapore 117543 ABSTRACT Images a rich source of image collection from which users can query. Interestingly, the semantics

  9. Video Behavior Profiling for Anomaly Detection Tao Xiang, Member, IEEE, and Shaogang Gong

    E-print Network

    Gong, Shaogang

    Video Behavior Profiling for Anomaly Detection Tao Xiang, Member, IEEE, and Shaogang Gong Abstract--This paper aims to address the problem of modeling video behavior captured in surveillance videos for the applications of online normal behavior recognition and anomaly detection. A novel framework is developed

  10. Design of Walking Gaits for TAO-PIE-PIE, a Small Humanoid Robot

    E-print Network

    Baltes, Jacky

    angular velocity in the left-right and forward-backward plane and a CMOS camera providing visionDesign of Walking Gaits for TAO-PIE-PIE, a Small Humanoid Robot Jacky Baltes and Patrick Lam://www.cs.umanitoba.ca/~jacky Category: Full Paper submitted to special edition on RoboCup Humanoid Robot Competition Keywords

  11. Comparison of TRMM rainfall retrievals with rain gauge data from the TAO/TRITON buoy array

    E-print Network

    Comparison of TRMM rainfall retrievals with rain gauge data from the TAO/TRITON buoy array Kenneth P. Bowman, Amy B. Phillips, and Gerald R. North Department of Atmospheric Sciences, Texas A) Microwave Imager (TMI) and Precipitation Radar (PR) are compared with in situ measurements by rain gauges

  12. Detecting and discriminating behavioural anomalies Chen Change Loy , Tao Xiang, Shaogang Gong

    E-print Network

    Gong, Shaogang

    Detecting and discriminating behavioural anomalies Chen Change Loy Ã, Tao Xiang, Shaogang Gong a c t This paper aims to address the problem of anomaly detection and discrimination in complex behaviours, where anomalies are subtle and difficult to detect owing to the complex temporal dynamics

  13. Knowledge Transformation by Cross-Domain Belief Propagation Fei Wang Tao Li

    E-print Network

    Li, Tao

    Knowledge Transformation by Cross-Domain Belief Propagation Fei Wang Tao Li School of Computing used in information retrieval. In this paper, we consider the problem of performing cross-domain belief knowledge on one type of variables can help knowledge discovery on the other type of variables with cross-domain

  14. LG based decision aid for naval tactical action officer's (TAO) workstation

    Microsoft Academic Search

    Boris Stilman; Vladimir Yakhnis; Oleg Umanskiy; Ron Boyd

    2005-01-01

    In the increasingly NetCentric battlespace of the 21st century, Stilman Advanced Strategies Linguistic Geometry software has the potential to revolutionize the way that the Navy fights in two key areas: as a Tactical Decision Aid and for creating a relevant Common Operating Picture. Incorporating STILMAN's software into a prototype Tactical Action Officers (TAO) workstation as a Tactical Decision Aid (TDA)

  15. Message Passing for Collective Graphical Models Tao Sun and Daniel Sheldon

    E-print Network

    Sheldon, Daniel R.

    Message Passing for Collective Graphical Models Tao Sun and Daniel Sheldon School of Computer Science University of Massachusetts Amherst Amherst, MA 01003 {taosun,sheldon}@cs.umass.edu Akshat Kumar free energy and the objective function for approximate MAP inference in CGMs (Sheldon et al., 2013

  16. The cultural and ecological impacts of aboriginal tourism: a case study on Taiwan's Tao tribe.

    PubMed

    Liu, Tzu-Ming; Lu, Dau-Jye

    2014-01-01

    We show that tourism activities severely impact the ecology of Orchid Island, its natural resources, and the culture of the Tao tribe. For example, highway widening, in response to the increased traffic volumes caused by tourism, required many Pandanus trees to be cut and removed, which has placed the coconut crabs in danger of extinction. To promote eco-tourism, observation trips to observe Elegant Scops owls and Birdwing butterflies have taken place, which has affected the breeding of these two protected species. The Elegant Scops owls- and Birdwing butterflies-related tourism activities also break the "evil spirits" taboo of the Tao people and have caused the disappearance of the specifications for using traditional natural resources, causing natural ecosystems to face the threat of excessive use. In addition to promoting and advocating aboriginal tourism of the Tao people on Orchid Island, the Taiwanese government should help the Tao people to develop a management model that combines traditional regulations and tourism activities. PMID:25089246

  17. On Virtualizing Ethernet Switches Mark McGinley, Tao Li, and Malathi Veeraraghavan

    E-print Network

    Veeraraghavan, Malathi

    instances. In our proposed solution for switch/router virtualization, soft- ware external to the switchOn Virtualizing Ethernet Switches Mark McGinley, Tao Li, and Malathi Veeraraghavan 151 Engineer network switches in order to create multiple logical switches from one physical switch. The motivation

  18. Design-for-Testability for Digital Microfluidic Biochips* Tao Xu and Krishnendu Chakrabarty

    E-print Network

    Chakrabarty, Krishnendu

    Design-for-Testability for Digital Microfluidic Biochips* Tao Xu and Krishnendu Chakrabarty-Testing is essential for digital microfluidic biochips that are used for safety-critical applications such as point not consider testability. We introduce the concept of design-for-testability (DFT) for microfluidic biochips

  19. Optimal Control of Multi-battery Energy-aware Systems Tao Wang and Christos G. Cassandras

    E-print Network

    Cassandras, Christos G.

    Optimal Control of Multi-battery Energy-aware Systems Tao Wang and Christos G. Cassandras Division batteries that can be shared to perform a given amount of work over some specified time period. We seek to maximize the minimum residual energy among all batteries at the end of this period by optimally controlling

  20. Association of TLR7 and TSHR copy number variation with Graves’ disease and Graves’ ophthalmopathy in Chinese population in Taiwan

    PubMed Central

    2014-01-01

    Background Graves’ disease (GD) and Graves’ ophthalmopathy (GO) are autoimmune disorders, which might be influenced by genetic factors. Copy number variation (CNV) is an important source of genomic diversity in humans, and influences disease susceptibility. This study investigated the association between CNV in the TSHR and TLR7 genes and the development of GD and GO in a Chinese population in Taiwan. Methods For this case-control study, sample from 196 healthy controls and 484 GD patients, including 203 patients with GO were studied. CNV was detected by real-time polymerase chain reaction (PCR) using TaqMan™ probes and the relative copy number (CN) was estimated by using the comparative Ct method. Results The differences in the distribution of TSHR CNV in healthy controls and GD patients were statistically significant (p value?=?0.01). However, the difference in the distribution of TSHR CNV in the control group and the GO group was not statistically significant (p value?=?0.06). For TLR7 CNV, the results were not significantly different when we compared the distribution in healthy controls and GD patients and in healthy controls and GO patients (p values for Fisher’s exact test were 0.13 and 0.09, respectively). However, a lower than normal CNV for TLR7 (CNV?

  1. Platelet-Derived Growth Factor: A Key Factor in the Pathogenesis of Graves' Ophthalmopathy and Potential Target for Treatment

    PubMed Central

    Virakul, Sita; van Steensel, Leendert; Dalm, Virgil A.S.H.; Paridaens, Dion; van Hagen, P. Martin; Dik, Willem A.

    2014-01-01

    Activation of orbital fibroblasts resulting in excessive proliferation, cytokine and hyaluronan production and differentiation into adipocytes, is a main determinant of orbital tissue inflammation and tissue expansion in Graves' ophthalmopathy (GO). During the last years we have shown that the platelet-derived growth factor (PDGF) isoforms PDGF-AA, PDGF-AB and PDGF-BB are increased in orbital tissue from GO patients with active and inactive disease. These PDGF isoforms exhibit the capacity to stimulate proliferation, hyaluronan and cytokine/chemokine production by orbital fibroblasts. Moreover, PDGF-AB and PDGF-BB increase thyroid stimulating hormone receptor (TSHR) expression by orbital fibroblasts, which enhances the orbital fibroblast activating capacity of the THSR stimulatory autoantibodies present in Graves' disease (GD) patients. Of these PDGF isoforms PDGF-BB exhibits the strongest orbital fibroblast activating effects, which is likely related to its ability to bind both the PDGF-receptor (PDGF-R)? and PDGF-R? chains. Thus the PDGF-system fulfills important roles in orbital fibroblast activation in both active and inactive GO, which supports a therapeutic rationale for blocking PDGF signaling in GO. Tyrosine kinase inhibitors (TKIs) may be candidates to target PDGF signaling. Of several TKIs tested dasatinib exhibited the highest potency to block PDGF-R signaling in orbital fibroblasts and may represent a promising compound for the treatment of GO as it was effective at low dosage and is associated with less side effects compared to imatinib mesylate and nilotinib. In this review the contribution of PDGF to the pathophysiology of GO as well as therapeutic approaches to target this PDGF-system will be addressed. PMID:25759797

  2. Platelet-derived growth factor: a key factor in the pathogenesis of graves' ophthalmopathy and potential target for treatment.

    PubMed

    Virakul, Sita; van Steensel, Leendert; Dalm, Virgil A S H; Paridaens, Dion; van Hagen, P Martin; Dik, Willem A

    2014-12-01

    Activation of orbital fibroblasts resulting in excessive proliferation, cytokine and hyaluronan production and differentiation into adipocytes, is a main determinant of orbital tissue inflammation and tissue expansion in Graves' ophthalmopathy (GO). During the last years we have shown that the platelet-derived growth factor (PDGF) isoforms PDGF-AA, PDGF-AB and PDGF-BB are increased in orbital tissue from GO patients with active and inactive disease. These PDGF isoforms exhibit the capacity to stimulate proliferation, hyaluronan and cytokine/chemokine production by orbital fibroblasts. Moreover, PDGF-AB and PDGF-BB increase thyroid stimulating hormone receptor (TSHR) expression by orbital fibroblasts, which enhances the orbital fibroblast activating capacity of the THSR stimulatory autoantibodies present in Graves' disease (GD) patients. Of these PDGF isoforms PDGF-BB exhibits the strongest orbital fibroblast activating effects, which is likely related to its ability to bind both the PDGF-receptor (PDGF-R)? and PDGF-R? chains. Thus the PDGF-system fulfills important roles in orbital fibroblast activation in both active and inactive GO, which supports a therapeutic rationale for blocking PDGF signaling in GO. Tyrosine kinase inhibitors (TKIs) may be candidates to target PDGF signaling. Of several TKIs tested dasatinib exhibited the highest potency to block PDGF-R signaling in orbital fibroblasts and may represent a promising compound for the treatment of GO as it was effective at low dosage and is associated with less side effects compared to imatinib mesylate and nilotinib. In this review the contribution of PDGF to the pathophysiology of GO as well as therapeutic approaches to target this PDGF-system will be addressed. PMID:25759797

  3. A genomic point mutation in the extracellular domain of the thyrotropin receptor in patients with Graves` ophthalmopathy

    SciTech Connect

    Bahn, R.S.; Dutton, C.M.; Heufelder, A.E.; Sarkar, G. [Mayo Clinic/Foundation, Rochester, MN (United States)] [Mayo Clinic/Foundation, Rochester, MN (United States); [Ludwig-Maximilians-Universitat, Munich (Germany)

    1994-02-01

    Orbital and pretibial fibroblasts are targets of autoimmune attack in Graves` ophthalmopathy (GO) and pretibial dermopathy (PTD). The fibroblast autoantigen involved in these peripheral manifestations of Graves` disease and the reason for the association of GO and PTD with hyperthyroidism are unknown. RNA encoding the full-length extracellular domain of the TSH receptor has been demonstrated in orbital and dermal fibroblasts from patients with GO and normal subjects, suggesting a possible antigenic link between fibroblasts and thyrocytes. RNA was isolated from cultured orbital, pretibial, and abdominal fibroblasts obtained from patients with severe GO (n = 22) and normal subjects (n = 5). RNA was reverse transcribed, and the resulting cDNA was amplified by the polymerase chain reaction, using primers spanning overlapping regions of the entire extracellular domain of the TSH receptor. Nucleotide sequence analysis showed an A for C substitution in the first position of codon 52 in 2 of the patients, both of whom had GO, PTD, and acropachy. Genomic DNA isolated from the 2 affected patients, and not from an additional 12 normal subjects, revealed the codon 52 mutation by direct sequencing and AciI restriction enzyme digestions. In conclusion, the authors have demonstrated the presence of a genomic point mutation, leading to a threonine for proline amino acid shift in the predicted peptide, in the extracellular domain of the TSH receptor in two patients with severe GO, PTD, acropachy, and high thyroid-stimulating immunoglobulin levels. RNA encoding this mutant product was demonstrated in the fibroblasts of these patients. They suggest that the TSH receptor may be an important fibroblast autoantigen in GO and PTD, and that this mutant form of the receptor may have unique immunogenic properties. 28 refs., 3 figs., 2 tabs.

  4. Structural Characterization of New Layered Perovskites MLa 2Ti 2TaO 10 ( M=Cs, Rb) and NaLa 2Ti 2TaO 10 · xH 2O ( x=2, 0.9, 0)

    NASA Astrophysics Data System (ADS)

    Hong, Young-Sik; Han, Chi-Hwan; Kim, Keon

    2001-05-01

    The crystal structures of n=3 Dion-Jacobson phases MLa2Ti2TaO10 (M=Cs, Rb) and NaLa2Ti2TaO10 ·xH2O (x=2, 0.9, 0) have been investigated by the Rietveld analysis of their powder XRD patterns. These compounds show the new-type ordering sequence of (Ti1/2Ta1/2)O6-TiO6-(Ti1/2Ta1/2)O6 in the tripled octahedra, corresponding to the niobium analogs of MLa2Ti2NbO10. They crystallize in the tetragonal system P4/mmm with lattice constants of a=3.84733(9) and c=15.4364(4) Å for CsLa2Ti2TaO10, and a=3.8342(2) and c=15.2776(9) Å for RbLa2Ti2TaO10. Sodium-exchanged phase was easily hydrated to NaLa2Ti2TaO10 ·2H2O, belonging to the space group I4/mmm with a=3.8399(3) and c=34.288(3) Å. Upon firing, NaLa2Ti2TaO10·2H2O was dehydrated to NaLa2Ti2TaO10·0.9H2O with P4/mmm at around 100°C and then NaLa2Ti2TaO10 with I4/mmm at above 200°C. The Na cations in two hydrates were surrounded with six oxygens, forming face-shared octahedra along (110) direction. These structural models, especially for the coordination environment of Na cations, were proposed for the first time.

  5. 77 FR 31036 - Notice of Availability of the Record of Decision for the Taos Resource Management Plan...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-24

    ...nm/taos. Copies of the ROD/Approved RMP are available for public inspection at the BLM New Mexico State Office at 301 Dinosaur Trail, Santa Fe, New Mexico. FOR FURTHER INFORMATION CONTACT: Brad Higdon, Planning and Environmental Coordinator,...

  6. A new perovskite PbIno, sTao. sO3 (PIT)

    Microsoft Academic Search

    Antoni Kania

    1990-01-01

    PbIno. 5Tao. 5O3 (PIT) single crystals have been grown using the flux method. Both pyrochlore and perovskite crystals have been obtained. The perovskite PIT crystals were partially ordered. The ?(T) dependence shows two anomalies at 150°C and 205°C. The low temperature phase in this ordered PIT is antiferroelectric with monoclinic distortion of the pseudo-perovskite unit cell.

  7. TOGA-TAO: A Moored Array for Real-time Measurements in the Tropical Pacific Ocean

    Microsoft Academic Search

    S. P. Hayes; L. J. Mangum; J. Picaut; A. Sumi; K. Takeuchi

    1991-01-01

    The importance of the El Niño-Southern Oscillation phenomenon in year-to-year fluctuations of the global climate has led to efforts to improve the real-time ocean observing system in the tropical Pacific. One element of this improved system is the TOGA-TAO (Tropical Atmosphere-Ocean) Array of wind and upper ocean thermistor chain moorings. This array, the result of an international effort, has already

  8. The epidemiologic characteristics and clinical course of ophthalmopathy associated with autoimmune thyroid disease in Olmsted County, Minnesota.

    PubMed Central

    Bartley, G B

    1994-01-01

    Among incident cases of GO in Olmsted County, Minnesota: GO affected females six times more frequently than males (86% versus 14% of cases, respectively). The age-adjusted incidence rate was 16 cases per 100,000 population per year for females and 2.9 cases per 100,000 population for males. The peak incidence rates were bimodal, occurring in the age groups 40 to 44 years and 60 to 64 years in females and 45 to 49 years and 65 to 69 years in males. Among patients with GO, approximately 90% had Graves' hyperthyroidism, 1% had primary hypothyroidism, 3% had Hashimoto's thyroiditis, and 5% were euthyroid. Eyelid retraction was the most common ophthalmic feature of autoimmune thyroid disease, being present either unilaterally or bilaterally in more than 90% of patients at some point in their clinical course. Exophthalmos of one or both eyes affected approximately 60% of patients, restrictive extraocular myopathy was apparent in about 40% of patients, and optic nerve dysfunction occurred in either one or both eyes in 6% of patients with autoimmune thyroid disease. Only 5% of patients had the complete constellation of classic findings: eyelid retraction, exophthalmos, optic nerve dysfunction, extraocular muscle involvement, and hyperthyroidism. Upper eyelid retraction, either unilateral or bilateral, was documented in approximately 75% of patients at the time of diagnosis of GO. Lid lag also was a frequent early sign, being present either unilaterally or bilaterally in 50% of patients at the initial examination. At the time of diagnosis of GO, the most frequent ocular symptom was pain or discomfort, which affected 30% of patients. Some degree of diplopia was noted by approximately 17% of patients, lacrimation or photophobia was present in about 15% to 20% of patients, and 7.5% of patients complained of blurred vision. Decreased vision attributable to optic neuropathy was present in less than 2% of eyes at the time of diagnosis of GO. Thyroid dermopathy and acropachy accompanied GO in approximately 4% and 1% of patients, respectively. Myasthenia gravis occurred in less than 1% of patients. Superior limbic keratoconjunctivitis was documented in less than 4% of patients. The median age at the time of diagnosis of GO was 43 years (range, 8 to 88). Among patients with hyperthyroidism, 61% developed ophthalmopathy within 1 year of the onset of thyrotoxicosis. Symptoms and signs for which statistically significant changes occurred between the initial and final examinations included lacrimation, pain or ocular discomfort, photophobia, eyelid retraction, lid lag, eyelid fullness, conjunctival injection, chemosis, and exophthalmos.(ABSTRACT TRUNCATED AT 400 WORDS) Images FIGURE 1 FIGURE 2 FIGURE 3 PMID:7886878

  9. Radionuclide concentrations in soils and produce from Cochiti, Jemez, Taos, and San Ildefonso Pueblo Gardens

    SciTech Connect

    Fresquez, P.R.; Armstrong, D.R.; Salazar, J.G.

    1995-05-01

    Radionuclide ({sup 3}H, {sup 90}Sr, {sup 137}Cs, {sup 238}Pu, {sup 239}Pu, and total uranium) concentrations were determined in soils and produce collected from Cochiti, Jemez, Taos, and San Ildefonso Pueblo gardens. All radionuclides in soils from Pueblo areas were within or just above regional statistical (natural and/or worldwide fallout) reference levels. Similarily, the average levels of radionuclides in produce collected from Cochiti, Jemez, Taos, and San Ildefonso Pueblo gardens were not significantly different in produce collected from regional (background) locations. The effective (radiation) dose equivalent from consuming 352 lb of produce from Cochiti, Jemez, Taos, and San Ildefonso, after natural background has been subtracted, was 0.036 ({+-}0.016), 0.072 ({+-}0.051), 0.012 ({+-}0.027), and 0.110 ({+-}0.102) mrem/yr, respectively. The highest calculated dose, based on the mean + 2 std dev (95% confidence level), was 0.314 mrem/yr; this was <0.4% of the International Commission on Radiological Protection permissible dose limit for protecting members of the public.

  10. Fabrication and characterization of Li 3TaO 4 ceramic pebbles by wet process

    NASA Astrophysics Data System (ADS)

    Zhu, Deqiong; Peng, Shuming; Chen, Xiaojun; Gao, Xiaoling; Yang, Tongzai

    2010-01-01

    Lithium-containing ceramics have long been recognized as the tritium breeding materials in the fusion-fission or fusion reactor blanket. Li 3TaO 4 (lithium orthotantalate) pebbles, with high melting point (˜1406 °C), good thermal stability, and high thermal conductivity, were fabricated by wet process (freeze-drying) as a new potential candidate of tritium breeder. The diameter of ceramic pebbles is 0.7-1.0 mm, density is over 90% (TD), pore diameter is 1.86 ?m (a.v), grain size is 15 ?m (a.v), crush load is up to 46.7 N (a.v).

  11. Electrode-material dependent switching in TaO x memristors

    NASA Astrophysics Data System (ADS)

    Ge, Ning; Zhang, M.-X.; Zhang, Lu; Yang, J. Joshua; Li, Zhiyong; Williams, R. Stanley

    2014-10-01

    We have studied the effect of top electrode materials on the switching behavior of TaO x based memristors with an identical switching oxide layer and bottom electrode stack. We found that the virgin resistance, electroforming and switching performance depend heavily on the chemical property of the top electrode materials. In addition, the electrical properties of metal oxides formed with the top electrodes also contribute to the overall memristor performance, including the nonlinearity of the current–voltage relationship. These results provide insights into understanding of memristor behavior as well as approaches for device property engineering.

  12. Modification of Tao–Mason equation of state to ionic liquids

    Microsoft Academic Search

    Fakhri Yousefi; Hajir Karimi

    In our previous paper, we extended the Tao and Mason equation of state (TM EOS) to refrigerant fluids, using the speed of\\u000a sound data. Here, we predict the equation of state for ionic liquids (ILs). The considered ILs are [Bmim][PF6], [C2mim][NtF2], [C3mim][NtF2], [C6mim][NtF2], [C7mim][NtF2], [C2mim][EtOSO3], [Bmim][MeSO4], [Bmim][OcSO4], and [C4mim][dca]. The equation of state consists of three temperature-dependent parameters: the second

  13. TAOS: Taiwan-American Occultation Survey of Comet-Sized Objects in the Kuiper Belt

    NASA Technical Reports Server (NTRS)

    Lissauer, Jack; DeVincenzi, Donald (Technical Monitor)

    1999-01-01

    Several dozen minor planets with radii greater than 100 km have been detected beyond Neptune using large telescopes. The TAOS project is to measure directly the number of these KBOs (Kuiper Belt Objects) down to the typical size of cometary nuclei (a few km) and out as far as approximately 100 AU from the Sun. Because of their large distance, small sizes and presumed low albedos, these target objects are extremely faint. Three 50 cm wide field robotic telescopes with 2048 x 2048 CCD cameras will be deployed along a 7 km east-west baseline in or near Jade Mountain National Park in Taiwan. They will monitor approximately 3000 stars for occultations by KBOs in a coincidence mode, so that the sequence and timing of the three separate blinkings can be used to distinguish real events from false alarms. Follow-up imaging observations using large telescopes will yield albedos and orbits for some of the larger objects detected by TAOS. A fourth telescope on a north-south spur to refine the size information on occulting GABON is also being contemplated.

  14. Bridging East and West--Or, a Bridge Too Far? Paulo Freire and the "Tao Te Ching"

    ERIC Educational Resources Information Center

    Roberts, Peter

    2012-01-01

    This article considers key differences and similarities between Freirean and Taoist ideals. I limit my focus to the "Tao Te Ching" (attributed to Lao Tzu), paying brief attention to the origins of this classic work of Chinese philosophy before concentrating on several themes of relevance to Freire's work. An essay by James Fraser (1997), who makes…

  15. TUMS: Twitter-based User Modeling Service Ke Tao, Fabian Abel, Qi Gao, Geert-Jan Houben

    E-print Network

    Langendoen, Koen

    TUMS: Twitter-based User Modeling Service Ke Tao, Fabian Abel, Qi Gao, Geert-Jan Houben Web. Twitter is today's most popular micro-blogging service on the Social Web. As people discuss various fresh topics, Twitter mes- sages (tweets) can tell much about the current interests and concerns of a user

  16. Regularity and uniqueness of the heat flow of biharmonic maps Jay Hineman, Tao Huang, and Changyou Wang

    E-print Network

    Wang, Changyou

    Regularity and uniqueness of the heat flow of biharmonic maps Jay Hineman, Tao Huang, and Changyou, we first establish regularity of the heat flow of biharmonic maps into the unit sphere SL RL+1 under for the heat flow of biharmonic maps is follows. For 0 map u W1,2 2 ( × [0, T], N

  17. Cation exchange in a 3D perovskite-synthesis of Ni(0.5)TaO?.

    PubMed

    Amano Patino, Midori; Smith, Thomas; Zhang, Weiguo; Halasyamani, P Shiv; Hayward, Michael A

    2014-08-01

    Reaction of NiCl2 with NaTaO3 leads the formation of the perovskite phase Ni(0.5)TaO3, via a topochemical nickel-for-sodium cation exchange in which the framework of apex-linked TaO6 octahedra present in the parent phase is retained. Neutron powder diffraction data indicate Ni(0.5)TaO3 adopts a structure analogous to the paraelectric phase of LiTaO3, with triclinic P1 crystallographic symmetry. Although Ni(0.5)TaO3 has features which make it a good candidate phase for magnetoelectric multiferroic behavior, the phase remains paramagnetic in the temperature range 15 < T (K) < 300, and detailed crystallographic characterization and analysis of SHG activity indicate it retains a centrosymmetric structure down to the lowest temperatures measured (5 K). Topochemical cation exchange reactions of 3D perovskite oxides offer the opportunity to prepare a wide range of novel metastable phases in a rational manner with a high degree of synthetic control. PMID:25050865

  18. Multiple Bytes Differential Fault Analysis on CLEFIA Xin-jie ZHAO, Tao WANG, Jing-zhe GAO

    E-print Network

    Multiple Bytes Differential Fault Analysis on CLEFIA Xin-jie ZHAO, Tao WANG, Jing-zhe GAO attack. Firstly, it presents the principle of CLEFIA algorithm and differential fault analysis; then fault models and corresponding analysis methods; finally, all of the fault model and analysis methods

  19. Conductivity of a suspension of nanowires in a weakly conducting medium Tao Hu, A. Yu. Grosberg, and B. I. Shklovskii

    E-print Network

    Minnesota, University of

    even at small volume frac- tions. For example, composites made of metallic wires with aspect ratio aConductivity of a suspension of nanowires in a weakly conducting medium Tao Hu, A. Yu. Grosberg 2006 We study the macroscopic electrical conductivity of a composite made of straight or coiled

  20. A second mutation in the type II procollagen gene (COL2A1) causing Stickler syndrome (arthro-ophthalmopathy) is also a premature termination codon

    SciTech Connect

    Ahmad, N.N.; Knowlton, R.G.; DiMascio, J.; Prockop, D.J. (Thomas Jefferson Univ., Philadelphia, PA (United States)); McDonald-McGinn, D.M.; Zackai, E.H.; LaRossa, D. (Children's Hospital, Philadelphia, PA (United States))

    1993-01-01

    Genetic linkage analyses suggest that mutations in type II collagen may be responsible for Stickler syndrome, or arthro-ophthalmopathy (AO), in many families. In the present study oligonucleotide primers were developed to amplify and directly sequence eight of the first nine exons of the gene for type II procollagen (COL2A1). Analysis of the eight exons in 10 unrelated probands with AO revealed that one had a single-base mutation in one allele that changed the codon of -CGA- for arginine at amino acid position [alpha]1-9 in exon 7 to a premature termination signal for translation. The second mutation found to cause AO was, therefore, similar to the first in that both created premature termination signals in the COL2A1 gene. Since mutations producing premature termination signals have not previously been detected in genes for fibrillar collagens, the results raise the possibility that such mutations in the COL2A1 gene are a common cause of AO. 33 refs., 4 figs., 2 tabs.

  1. Stop codon in the procollagen II gene (COL2A1) in a family with the Stickler syndrome (arthro-ophthalmopathy)

    SciTech Connect

    Ahmad, N.N.; Ala-Kokko, L.; Knowlton, R.G.; Jimenez, S.A.; Weaver, E.J.; Prockop, D.J. (Thomas Jefferson Univ., Philadelphia, PA (United States)); Maguire, J.I.; Tasman, W. (Wills Eye Hospital, Philadelphia, PA (United States))

    1991-08-01

    Linkage analysis with restriction fragment length polymorphisms for the gene for type II procollagen (COL2A1) was carried out in a family with the Stickler syndrome, or arthro-ophthalmopathy, an autosomal dominant disorder that affects the eyes, ears, joints, and skeleton. The analysis demonstrated linkage of the disease and COL2A1 with a logarithm-of-odds score of 1.51 at zero recombination. A newly developed procedure for preparing cosmid clones was employed to isolate the allele for type II procollagen that was linked to the disease. Analysis of over 7000 nucleotides of the gene revealed a single base mutation that altered a CG dinucleotide and converted the codon CGA for arginine at amino acid position {alpha}1-732 to TGA, a stop codon. From previous work on procollagen biosynthesis, it is apparent that the truncated polypeptide synthesized from an allele with a stop codon at {alpha}1-732 cannot participate in the assembly of type II procollagen, and therefore that the mutation would decrease synthesis of type II procollagen. It was not apparent, however, why the mutation produced marked changes in the eye, which contains only small amounts of type II collagen, but relatively mild effects on the many cartilaginous structures of the body that are rich in the same protein.

  2. Institutional Adaptation and Community-Based Conservation of Natural Resources: The Cases of the Tao and Atayal in Taiwan

    Microsoft Academic Search

    Ching-Ping Tang; Shui-Yan Tang

    2010-01-01

    Traditional institutional rules, values, and beliefs help support conservation regimes of natural resources in many indigenous\\u000a communities. Such traditional conservation regimes may break down as a result of influences from the outside world. This paper\\u000a examines two cases in Taiwan—the Tao communities on Orchid Island and the Atayal community in Smangus. The former illustrates\\u000a a process in which traditional institutions

  3. Realization of a reversible switching in TaO2 polymorphs via Peierls distortion for resistance random access memory

    NASA Astrophysics Data System (ADS)

    Zhu, Linggang; Zhou, Jian; Guo, Zhonglu; Sun, Zhimei

    2015-03-01

    Transition-metal-oxide based resistance random access memory (RRAM) is a promising candidate for next-generation universal non-volatile memories. Searching and designing appropriate materials used in the memories becomes an urgent task. Here, a structure with the TaO2 formula was predicted using evolutionary algorithms in combination with first-principles calculations. This triclinic structure (T-TaO2) is both energetically and dynamically more favorable than the commonly believed rutile structure (R-TaO2). The metal-insulator transition (MIT) between metallic R-TaO2 and T-TaO2 (band gap: 1.0 eV) is via a Peierls distortion, which makes TaO2 a potential candidate for RRAM. The energy barrier for the reversible phase transition is 0.19 eV/atom and 0.23 eV/atom, respectively, suggesting low power consumption for the resistance switch. The present findings about the MIT as the resistance-switch mechanism in Ta-O system will stimulate experimental work to fabricate tantalum oxides based RRAM.

  4. ANIR: Atacama near-infrared camera for the 1.0 m miniTAO telescope

    NASA Astrophysics Data System (ADS)

    Konishi, Masahiro; Motohara, Kentaro; Tateuchi, Ken; Takahashi, Hidenori; Kitagawa, Yutaro; Kato, Natsuko; Sako, Shigeyuki; Uchimoto, Yuka K.; Toshikawa, Koji; Ohsawa, Ryou; Yamamuro, Tomoyasu; Asano, Kentaro; Ita, Yoshifusa; Kamizuka, Takafumi; Komugi, Shinya; Koshida, Shintaro; Manabe, Sho; Matsunaga, Noriyuki; Minezaki, Takeo; Morokuma, Tomoki; Nakashima, Asami; Takagi, Toshinobu; Tanabé, Toshihiko; Uchiyama, Mizuho; Aoki, Tsutomu; Doi, Mamoru; Handa, Toshihiro; Kato, Daisuke; Kawara, Kimiaki; Kohno, Kotaro; Miyata, Takashi; Nakamura, Tomohiko; Okada, Kazushi; Soyano, Takao; Tamura, Yoichi; Tanaka, Masuo; Tarusawa, Ken'ichi; Yoshii, Yuzuru

    2015-02-01

    We have developed a near-infrared camera called ANIR (Atacama Near-InfraRed camera) for the University of Tokyo Atacama Observatory 1.0 m telescope (miniTAO) installed at the summit of Cerro Chajnantor (5640 m above sea level) in the north of Chile. The camera provides a field of view of 5{^'.}1 × 5{^'.}1 with a spatial resolution of 0{^''.}298 pixel-1 in the wavelength range of 0.95 to 2.4 ?m, using Offner relay optics and a PACE HAWAII-2 focal plane array. Taking advantage of the dry site, the camera is capable of narrow-band imaging observations at the hydrogen Paschen-? (Pa?, ? = 1.8751 ?m in air) wavelength ground-based observations of which have been quite difficult due to deep atmospheric absorption, mainly from water vapor. We have been successfully obtaining Pa? images of Galactic objects and nearby galaxies since the first-light observation in 2009 with ANIR. The throughputs at the narrow-band filters (N1875, N191) including the atmospheric absorption show larger dispersion (˜ 10%) than those at broad-band filters (a few percent), indicating that they are affected by temporal fluctuations in precipitable water vapor (PWV) above the site. We evaluate the PWV content via the atmospheric transmittance at the narrow-band filters, and deduce that the median and the dispersion of the distribution of the PWV are 0.40 ± 0.30 and 0.37 ± 0.21 mm, for the N1875 and N191 data respectively, which are remarkably smaller (49% ± 38% for N1875 and 59% ± 26% for N191) than radiometry measurements at the base of Cerro Chajnantor (an altitude of 5100 m). The decrease in PWV can be explained by the altitude of the site when we assume that the vertical distribution of the water vapor is approximated at an exponential profile with scale heights within 0.3-1.9 km (previously observed values at night). We thus conclude that miniTAO/ANIR at the summit of Cerro Chajnantor indeed provides us an excellent capability for a ground-based Pa? observation.

  5. ANIR : Atacama Near-Infrared Camera for the 1.0-m miniTAO Telescope

    E-print Network

    Konishi, Masahiro; Tateuchi, Ken; Takahashi, Hidenori; Kitagawa, Yutaro; Kato, Natsuko; Sako, Shigeyuki; Uchimoto, Yuka K; Toshikawa, Koji; Ohsawa, Ryou; Yamamuro, Tomoyasu; Asano, Kentaro; Ita, Yoshifusa; Kamizuka, Takafumi; Komugi, Shinya; Koshida, Shintaro; Manabe, Sho; Matsunaga, Noriyuki; Minezaki, Takeo; Morokuma, Tomoki; Nakashima, Asami; Takagi, Toshinobu; Tanabé, Toshihiko; Uchiyama, Mizuho; Aoki, Tsutomu; Doi, Mamoru; Handa, Toshihiro; Kato, Daisuke; Kawara, Kimiaki; Kohno, Kotaro; Miyata, Takashi; Nakamura, Tomohiko; Okada, Kazushi; Soyano, Takao; Tamura, Yoichi; Tanaka, Masuo; Tarusawa, Ken'ichi; Yoshii, Yuzuru

    2015-01-01

    We have developed a near-infrared camera called ANIR (Atacama Near-InfraRed camera) for the University of Tokyo Atacama Observatory 1.0m telescope (miniTAO) installed at the summit of Cerro Chajnantor (5640 m above sea level) in northern Chile. The camera provides a field of view of 5'.1 $\\times$ 5'.1 with a spatial resolution of 0".298 /pixel in the wavelength range of 0.95 to 2.4 $\\mu$m. Taking advantage of the dry site, the camera is capable of hydrogen Paschen-$\\alpha$ (Pa$\\alpha$, $\\lambda=$1.8751 $\\mu$m in air) narrow-band imaging observations, at which wavelength ground-based observations have been quite difficult due to deep atmospheric absorption mainly from water vapor. We have been successfully obtaining Pa$\\alpha$ images of Galactic objects and nearby galaxies since the first-light observation in 2009 with ANIR. The throughputs at the narrow-band filters ($N1875$, $N191$) including the atmospheric absorption show larger dispersion (~10%) than those at broad-band filters (a few %), indicating that ...

  6. Search for Small Trans-Neptunian Objects by the TAOS Project

    E-print Network

    W. P. Chen; C. Alcock; T. Axelrod; F. B. Bianco; Y. I. Byun; Y. H. Chang; K. H. Cook; R. Dave; J. Giammarco; D. W. Kim; S. K. King; T. Lee; M. Lehner; C. C. Lin; H. C. Lin; J. J. Lissauer; S. Marshall; N. Meinshausen; S. Mondal; I. de Pater; R. Porrata; J. Rice; M. E. Schwamb; A. Wang; S. Y. Wang; C. Y. Wen; Z. W. Zhang

    2006-11-16

    The Taiwan-America Occultation Survey (TAOS) aims to determine the number of small icy bodies in the outer reach of the Solar System by means of stellar occultation. An array of 4 robotic small (D=0.5 m), wide-field (f/1.9) telescopes have been installed at Lulin Observatory in Taiwan to simultaneously monitor some thousand of stars for such rare occultation events. Because a typical occultation event by a TNO a few km across will last for only a fraction of a second, fast photometry is necessary. A special CCD readout scheme has been devised to allow for stellar photometry taken a few times per second. Effective analysis pipelines have been developed to process stellar light curves and to correlate any possible flux changes among all telescopes. A few billion photometric measurements have been collected since the routine survey began in early 2005. Our preliminary result of a very low detection rate suggests a deficit of small TNOs down to a few km size, consistent with the extrapolation of some recent studies of larger (30--100 km) TNOs.

  7. Search for Small Trans-Neptunian Objects by the TAOS Project

    E-print Network

    Chen, W P; Axelrod, T; Bianco, F B; Byun, Y I; Chang, Y H; Cook, K H; Davé, R; Giammarco, J; Kim, D W; King, S K; Lee, T; Lehner, M; Lin, C C; Lin, H C; Lissauer, J J; Marshall, S; Meinshausen, N; Mondal, S A; De Pater, I; Porrata, R; Rice, J; Schwamb, M E; Wang, A; Wang, S Y; Wen, C Y; Zhang, Z W

    2006-01-01

    The Taiwan-America Occultation Survey (TAOS) aims to determine the number of small icy bodies in the outer reach of the Solar System by means of stellar occultation. An array of 4 robotic small (D=0.5 m), wide-field (f/1.9) telescopes have been installed at Lulin Observatory in Taiwan to simultaneously monitor some thousand of stars for such rare occultation events. Because a typical occultation event by a TNO a few km across will last for only a fraction of a second, fast photometry is necessary. A special CCD readout scheme has been devised to allow for stellar photometry taken a few times per second. Effective analysis pipelines have been developed to process stellar light curves and to correlate any possible flux changes among all telescopes. A few billion photometric measurements have been collected since the routine survey began in early 2005. Our preliminary result of a very low detection rate suggests a deficit of small TNOs down to a few km size, consistent with the extrapolation of some recent studi...

  8. Low thermal conductivity without oxygen vacancies in equimolar YO 1.5 + TaO 2.5- and YbO 1.5 + TaO 2.5-stabilized tetragonal zirconia ceramics

    Microsoft Academic Search

    Yang Shen; Rafael M. Leckie; Carlos G. Levi; David R. Clarke

    2010-01-01

    A narrow range of composition exists along both the ZrO2–YTaO4 and ZrO2–YbTaO4 quasi-binaries over which the tetragonal zirconia phase can be retained on cooling. Unlike other stabilized zirconia materials which have low thermal conductivity as a result of phonon scattering by oxygen vacancies, these compositions do not contain oxygen vacancies and yet an equimolar YO1.5+TaO2.5 composition has been reported to

  9. LG based decision aid for naval tactical action officer's (TAO) workstation

    NASA Astrophysics Data System (ADS)

    Stilman, Boris; Yakhnis, Vladimir; Umanskiy, Oleg; Boyd, Ron

    2005-05-01

    In the increasingly NetCentric battlespace of the 21st century, Stilman Advanced Strategies Linguistic Geometry software has the potential to revolutionize the way that the Navy fights in two key areas: as a Tactical Decision Aid and for creating a relevant Common Operating Picture. Incorporating STILMAN's software into a prototype Tactical Action Officers (TAO) workstation as a Tactical Decision Aid (TDA) will allow warfighters to manage their assets more intelligently and effectively. This prototype workstation will be developed using human-centered design principles and will be an open, component-based architecture for combat control systems for future small surface combatants. It will integrate both uninhabited vehicles and onboard sensors and weapon systems across a squadron of small surface combatants. In addition, the hypergame representation of complex operations provides a paradigm for the presentation of a common operating picture to operators and personnel throughout the command hierarchy. In the hypergame technology there are game levels that span the range from the tactical to the global strategy level, with each level informing the others. This same principle will be applied to presenting the relevant common operating picture to operators. Each operator will receive a common operating picture that is appropriate for their level in the command hierarchy. The area covered by this operating picture and the level of detail contained within it will be dependent upon the specific tasks the operator is performing (supervisory vice tactical control) and the level of the operator (or command personnel) within the command hierarchy. Each level will inform the others to keep the picture concurrent and up-to-date.

  10. Observation of greenhouse gases from ground-based telescope "Subaru" and "TAO"

    NASA Astrophysics Data System (ADS)

    Hayashi, Y.; Imasu, R.; Miyata, T.

    2009-12-01

    Long-term observation of greenhouse gases is very important to understand temporal variations of greenhouse gases. This January, Japanese satellite, GOSAT (greenhouse gases observing satellite) was launched and its operational observation has started. For supporting satellite observations, validation data such as obtained by ground-based observations are very important. However, there is no observation site in South America. In this study, I propose new data analysis procedure for the observation of greenhouse gases using a ground-based astronomical telescope, which is placed in South America. The purpose of this study is to measure the vertical distribution and temporal variation of greenhouse gases such as methane and ozone from infrared spectrum data measured by an astronomical telescope on the ground. Although solar radiation is generally used to measure greenhouse gases, we use stellar radiation in order to measure the gases even in the night. The method developed in this study can be applicable for analysis of the data observed at world wide astronomical observatories. Institute of Astronomy, The University of Tokyo has conducted an international project, TAO (University of Tokyo Atacama Observatory) Project. In this project they are constructing a very big size telescope (diameter of the main mirror is 6m) at the observation site in Chile, South America. We are going to measure greenhouse gases using the telescope. However, as it is still under construction, we use the data from another Japanese telescope, “Subaru” in Hawaii. Subaru telescope, which has 7 instruments, is located at the top of Mauna Kea, Hawaii. In this study, we use mid-infrared grating spectrometer, called COMICS. This instrument provides spectroscopic capabilities from 7.5-13.5 um, which include absorption bands methane and ozone. To analyze these greenhouse gases, we developed a new method using two stars which have different zenith angles observed in a short interval. I will present some preliminary results retrieved from Subaru data.

  11. MST3 kinase phosphorylates TAO1/2 to enable Myosin Va function in promoting spine synapse development.

    PubMed

    Ultanir, Sila K; Yadav, Smita; Hertz, Nicholas T; Oses-Prieto, Juan A; Claxton, Suzanne; Burlingame, Alma L; Shokat, Kevan M; Jan, Lily Y; Jan, Yuh-Nung

    2014-12-01

    Mammalian Sterile 20 (Ste20)-like kinase 3 (MST3) is a ubiquitously expressed kinase capable of enhancing axon outgrowth. Whether and how MST3 kinase signaling might regulate development of dendritic filopodia and spine synapses is unknown. Through shRNA-mediated depletion of MST3 and kinase-dead MST3 expression in developing hippocampal cultures, we found that MST3 is necessary for proper filopodia, dendritic spine, and excitatory synapse development. Knockdown of MST3 in layer 2/3 pyramidal neurons via in utero electroporation also reduced spine density in vivo. Using chemical genetics, we discovered thirteen candidate MST3 substrates and identified the phosphorylation sites. Among the identified MST3 substrates, TAO kinases regulate dendritic filopodia and spine development, similar to MST3. Furthermore, using stable isotope labeling by amino acids in culture (SILAC), we show that phosphorylated TAO1/2 associates with Myosin Va and is necessary for its dendritic localization, thus revealing a mechanism for excitatory synapse development in the mammalian CNS. PMID:25456499

  12. MST3 Kinase Phosphorylates TAO1/2 to Enable Myosin Va Function in Promoting Spine Synapse Development

    PubMed Central

    Ultanir, Sila K.; Yadav, Smita; Hertz, Nicholas T.; Oses-Prieto, Juan A.; Claxton, Suzanne; Burlingame, Alma L.; Shokat, Kevan M.; Jan, Lily Y.; Jan, Yuh-Nung

    2014-01-01

    Summary Mammalian Sterile 20 (Ste20)-like kinase 3 (MST3) is a ubiquitously expressed kinase capable of enhancing axon outgrowth. Whether and how MST3 kinase signaling might regulate development of dendritic filopodia and spine synapses is unknown. Through shRNA-mediated depletion of MST3 and kinase-dead MST3 expression in developing hippocampal cultures, we found that MST3 is necessary for proper filopodia, dendritic spine, and excitatory synapse development. Knockdown of MST3 in layer 2/3 pyramidal neurons via in utero electroporation also reduced spine density in vivo. Using chemical genetics, we discovered thirteen candidate MST3 substrates and identified the phosphorylation sites. Among the identified MST3 substrates, TAO kinases regulate dendritic filopodia and spine development, similar to MST3. Furthermore, using stable isotope labeling by amino acids in culture (SILAC), we show that phosphorylated TAO1/2 associates with Myosin Va and is necessary for its dendritic localization, thus revealing a mechanism for excitatory synapse development in the mammalian CNS. PMID:25456499

  13. On-the-Fly Pipeline Parallelism I-Ting Angelina Lee* Charles E. Leiserson* Tao B. Schardl* Jim Sukha Zhunping Zhang*

    E-print Network

    Leiserson, Charles E.

    On-the-Fly Pipeline Parallelism I-Ting Angelina Lee* Charles E. Leiserson* Tao B. Schardl* Jim Pipeline parallelism organizes a parallel program as a linear se- quence of s stages. Each stage processes element before the subsequent stages have nec- essarily completed their processing. Pipeline parallelism

  14. STRESS AND EMOTION CLASSIFICATION USING JITTER AND SHIMMER FEATURES Xi Li', Jidong Tao1, Michael T. Johnson1, Joseph Soltis2, Anne Savage2, Kirsten M. Leong3,

    E-print Network

    Johnson, Michael T.

    STRESS AND EMOTION CLASSIFICATION USING JITTER AND SHIMMER FEATURES Xi Li', Jidong Tao1, Michael T, stresses and emotions has generated considerable research in recent years [1-3]. This task has application improve the ability of researchers in bioacoustics to understand animal behavior. For both these tasks

  15. Spectrum Prediction in Cognitive Radio Networks Xiaoshuang Xing1,Tao Jing1,Wei Cheng2 Yan Huo1, Xiuzhen Cheng3

    E-print Network

    Cheng, Xiuzhen "Susan"

    Spectrum Prediction in Cognitive Radio Networks Xiaoshuang Xing1,Tao Jing1,Wei Cheng2 Yan Huo1}@bjtu.edu.cn, wcheng@cs.uml.edu, yhuo@bjtu.edu.cn, cheng@gwu.edu Abstract--Spectrum sensing, spectrum decision, spectrum sharing, and spectrum mobility are four major functions of cognitive radio (CR) systems. Spectrum

  16. EXAFS structure refinement supplemented by computational chemistry Ya-Wen Hsiao,1 Ye Tao,2 Jacob E. Shokes,2 Robert A. Scott,2 and Ulf Ryde1,

    E-print Network

    Scott, Robert A.

    EXAFS structure refinement supplemented by computational chemistry Ya-Wen Hsiao,1 Ye Tao,2 Jacob E extended x-ray absorption fine structure EXAFS measurements and computational chemistry CC calculations, EXAFS/CC. Using such an approach, it is possible to obtain a full structure of model complexes

  17. Inferring Resource Specifications from Natural Language API Documentation Hao Zhong1,2, Lu Zhang1,2,, Tao Xie3,, Hong Mei1,2,

    E-print Network

    Xie, Tao

    ), Ministry of Education, China 2 Institute of Software, School of Electronics Engineering and Computer,2,, Tao Xie3,, Hong Mei1,2, 1 Key Laboratory of High Confidence Software Technologies (Peking University@sei.pku.edu.cn Abstract--Typically, software libraries provide API docu- mentation, through which developers can learn how

  18. Automated classification of single airborne particles from two-dimensional angle-resolved optical scattering (TAOS) patterns by non-linear filtering

    NASA Astrophysics Data System (ADS)

    Crosta, Giovanni Franco; Pan, Yong-Le; Aptowicz, Kevin B.; Casati, Caterina; Pinnick, Ronald G.; Chang, Richard K.; Videen, Gorden W.

    2013-12-01

    Measurement of two-dimensional angle-resolved optical scattering (TAOS) patterns is an attractive technique for detecting and characterizing micron-sized airborne particles. In general, the interpretation of these patterns and the retrieval of the particle refractive index, shape or size alone, are difficult problems. By reformulating the problem in statistical learning terms, a solution is proposed herewith: rather than identifying airborne particles from their scattering patterns, TAOS patterns themselves are classified through a learning machine, where feature extraction interacts with multivariate statistical analysis. Feature extraction relies on spectrum enhancement, which includes the discrete cosine FOURIER transform and non-linear operations. Multivariate statistical analysis includes computation of the principal components and supervised training, based on the maximization of a suitable figure of merit. All algorithms have been combined together to analyze TAOS patterns, organize feature vectors, design classification experiments, carry out supervised training, assign unknown patterns to classes, and fuse information from different training and recognition experiments. The algorithms have been tested on a data set with more than 3000 TAOS patterns. The parameters that control the algorithms at different stages have been allowed to vary within suitable bounds and are optimized to some extent. Classification has been targeted at discriminating aerosolized Bacillus subtilis particles, a simulant of anthrax, from atmospheric aerosol particles and interfering particles, like diesel soot. By assuming that all training and recognition patterns come from the respective reference materials only, the most satisfactory classification result corresponds to 20% false negatives from B. subtilis particles and <11% false positives from all other aerosol particles. The most effective operations have consisted of thresholding TAOS patterns in order to reject defective ones, and forming training sets from three or four pattern classes. The presented automated classification method may be adapted into a real-time operation technique, capable of detecting and characterizing micron-sized airborne particles.

  19. Beyond the Tao-Thouless limit of the fractional quantum Hall effect: spin chains and Fermi surface deformation

    NASA Astrophysics Data System (ADS)

    Nakamura, Masaaki; Wang, Zheng-Yuan; Bergholtz, Emil J.

    2011-07-01

    We discuss the relationship between the fractional quantum Hall effect in the vicinity of the thin-torus, a.k.a. Tao-Thouless (TT), limit and quantum spin chains. We argue that the energetics of fractional quantum Hall states in Jain sequence at filling fraction ? = p/(2p + 1) (and ? = 1 - p/(2p + 1)) in the lowest Landau level is captured by S = 1 spin chains with p spins in the unit cell. These spin chains naturally arise at sub-leading order in e-2?2 / L21 which serves as an expansion parameter away from the TT limit (L1 ? 0). We also corroborate earlier results on the smooth Fermi surface deformation of the gapless state at ? = 1/2, interpolating between a state described by a critical S = 1/2 chain and the bulk.

  20. Dietary shift in corallivorous Drupella snails following a major bleaching event at Koh Tao, Gulf of Thailand

    NASA Astrophysics Data System (ADS)

    Hoeksema, B. W.; Scott, C.; True, J. D.

    2013-06-01

    The island Koh Tao in the western Gulf of Thailand suffered severe coral bleaching in 2010. Its mushroom coral fauna of 20 species was surveyed during the bleaching in 2010 and after the bleaching in 2011. Multi-species assemblages of free-living mushroom corals occurred around the island, two of which were invaded by corallivorous Drupella snails after the bleaching. Previously these gastropods were known to mainly consume branching corals and hardly any mushroom corals. The snails were found preying on four fungiid species, three of which were susceptible to bleaching. The dietary shift became apparent after populations of preferred prey species (Acroporidae and Pocilloporidae) had died during the bleaching event. It seems that bleaching mortality reduced the availability of preferred prey, causing the corallivores to switch to less preferred species that occur in dense aggregations.

  1. Low-temperature structural and dielectric phenomena in La1/3NbO3 and La1/3TaO3: Comparative study

    NASA Astrophysics Data System (ADS)

    Salak, Andrei N.; Vyshatko, Nikolai P.; Khalyavin, Dmitry D.; Prokhnenko, Oleksandr; Ferreira, Victor M.

    2008-10-01

    The crystal structures of the perovskites La1/3NbO3 and La1/3TaO3 were studied between 10 and 350 K using high-resolution neutron powder diffraction and compared with their radio-frequency dielectric response over the same temperature range. The structure of La1/3NbO3 remains orthorhombic Cmmm, while La1/3TaO3 undergoes continuous transition from the high-temperature tetragonal P4/mmm to Cmmm phase at about 220 K. This transition is tricritical in nature and accompanied by no dielectric anomaly. In La1/3NbO3, the frequency-dependent peak of the dielectric permittivity is associated with an atypical increase in the lattice parameters below about 80 K.

  2. Benchmarking the (1+1)-CMA-ES on the BBOB-2009 Noisy TAO Team, INRIA Saclay Ile-de-France

    E-print Network

    Paris-Sud XI, Université de

    Benchmarking the (1+1)-CMA-ES on the BBOB-2009 Noisy Testbed Anne Auger TAO Team, INRIA Saclay Ile We benchmark an independent-restart-(1+1)-CMA-ES on the BBOB-2009 noisy testbed. The (1+1)-CMA com- putation, CMA-ES 1. INTRODUCTION The (1+1)-CMA-ES is an adaptive stochastic search algo- rithm

  3. Conundrums in the legal protection of migrant workers' health rights and relative resolutions: implications from the case of Tseng Hei-tao.

    PubMed

    Liu, Kai

    2013-08-01

    The deteriorating situation of migrant workers' health rights protection was once again highlighted in the case of Tseng Hei-tao. This case explicitly and implicitly showed that four conundrums--the Employment Restriction Conundrum, the Occupational Safety and Health (OSH) Legal Conundrum, the Morality Conundrum and the Identity Conundrum--are barriers to migrant workers' right protection. The health rights of migrant workers could be safeguarded by abolishing the outdated household registration system designed in the planned economy era, improving the rule of law, and strengthening administrative supervisions. This would fundamentally remove these barriers and thus contribute to migrant workers' health rights protection. PMID:23073738

  4. Electrochemical oxidation of tannic acid contaminated wastewater by RuO2/IrO2/TaO2-coated titanium and graphite anodes.

    PubMed

    Govindaraj, M; Muthukumar, M; Raju, G Bhaskar

    2010-12-14

    The electrochemical oxidation of tannic acid contaminated wastewater by RuO2/IrO2/TaO2-coated titanium and graphite anodes has been investigated. The effect of the process variables, such as initial pH, current density, processing time, concentration of the electrolyte and anode materials, on the degradation of tannic acid was studied. During the various stages of electrolysis, parameters such as COD, chloride ion concentration and UV-Vis spectra were examined and discussed. The maximum chemical oxygen demand (COD) removal efficiency of 94% was achieved at pH 5, operated at the current density of 8.10 mA/cm2, electrolyte (NaCl) concentration of 0.1 M and at 60 min of electrolysis using graphite anodes. The experimental results showed that the electrochemical oxidation process could effectively reduce the COD from the tannic acid contaminated wastewater. An acidic pH showed the maximum reduction of COD compared with neutral and alkaline pH. Increase in current density, process time and electrolyte (NaCl) concentration with the increase in COD removal. Graphite anodes showed maximum removal of COD and better tannic acid degradation when compared with RuO2/IrO2/TaO2-coated titanium anodes. PMID:21275257

  5. SDI: Solar Dome Instrument for Solar Irradiance Monitoring Tao Liu1, Ankur U. Kamthe1, Varick L. Erickson1, Carlos F. M. Coimbra2 and Alberto E. Cerpa1

    E-print Network

    Cerpa, Alberto E.

    SDI: Solar Dome Instrument for Solar Irradiance Monitoring Tao Liu1, Ankur U. Kamthe1, Varick L data for ground solar irradiance (direct normal and global irradiance) is a major obstacle for the de- velopment of adequate policies to promote and take advan- tage of existing solar technologies. Although

  6. The Tao of SOA

    NASA Astrophysics Data System (ADS)

    Shan, Tony C.

    This paper describes a comprehensive framework aiming to facilitate the effective adoption and operationalization of SOA in large enterprise computing environments, which consists of the Strategy, Automation, Methodology, Patterns, Lifecycle, and Engineering (SAMPLE) aspects. The major pain points in SOA are analyzed, such as the increasing dynamics, growing integration, proliferation of techniques, more heterogeneous platforms, disparate visual notations, intricate processes, disjointed operating models, and fragmented activities of WS-* specifications. The overarching SAMPLE model is designed to provide a sophisticated integration of appropriate capabilities and knowledge to filter the inessential from the essential. In the Strategy aspect, a metamodel, technology architecture planning, and strategy roadmapping are presented. The Automation aspect deals with tools, service lifecycle, and COTS mapping. The Methodology aspect covers a hybrid method, SOA principles, and a methodical process. The prominent elements of the Patterns aspect include data caching patterns, a reference model, and open source reference implementation. The Lifecycle aspect contains a methodical means to mature IT systems: review, refactoring, reengineering, and rearchitecting (R4). Finally, the Engineering aspect evolves the traditional software engineering and systems engineering practices to the service engineering discipline. Moreover, a 10-point list of SOA guidance is introduced from a practitioner’s standpoint, which gives best-practice guidelines to adopt and execute SOA practically in big organizations.

  7. Cybernetics of Tao

    Microsoft Academic Search

    Zude Ye; Maurice Yolles

    2010-01-01

    Purpose – Taoist thought is not easily penetrable for Westerners, though it has growing importance with the globalisation of Chinese commerce. The purpose of this paper is to explore some aspects of Chinese and Taoist thought, and how they can be expressed in cybernetic terms, using a knowledge cybernetics (KC) schema. Design\\/methodology\\/approach – KC operates through metaphor the role of

  8. Protective Effects of Tao-Hong-Si-Wu Decoction on Memory Impairment and Hippocampal Damage in Animal Model of Vascular Dementia

    PubMed Central

    Han, Lan; Ji, Zhaojie; Chen, Weidong; Yin, Dengke; Xu, Fan; Li, Shanshan; Chen, Fangfang; Zhu, Guangyu; Peng, Daiyin

    2015-01-01

    Tao-Hong-Si-Wu decoction (TSD) as a traditional chinese medicine (TCM) has been developed to treat thrombotic diseases for hundreds of years, and vascular dementia (VD) is a cognitive dysfunction syndrome caused by cerebral embolism. In this study, the protective effect of TSD on memory impairment and brain damage in rat model of VD induced by middle cerebral artery occlusion (MCAO) was investigated. The study showed that rats in MCAO treatment with TSD for 14 days significantly improved behavioral function, increased densities of neuron, and induced angiogenesis in the brain compared with model rats. TSD also adjusted the neurotransmitter levels, reduced the content of endothelin-1 (ET-1), and induced the activities of vascular endothelial growth factor (VEGF) in hippocampus. Moreover, the immunohistochemical staining and western blotting results also revealed that TSD decreased apoptosis via upregulated B-cell lymphoma-2 (Bcl-2)/Bcl-2 associated X protein (Bax) ratio. These results demonstrated TSD possesses neuroprotective and antidementia properties by preventing the loss of neural cells, adjusting brain neurotransmitter, promoting cerebral blood circulation, and decreasing apoptosis. These results suggested that TSD might be developed as an effective drug for the prevention of VD. PMID:25821478

  9. Revised specifications and current development status of MIMIZUKU: the mid-infrared instrument for the TAO 6.5-m telescope

    NASA Astrophysics Data System (ADS)

    Kamizuka, Takafumi; Miyata, Takashi; Sako, Shigeyuki; Ohsawa, Ryou; Asano, Kentaro; Uchiyama, Mizuho; Okada, Kazushi; Uchiyama, Masahito; Nakamura, Tomohiko; Sakon, Itsuki; Onaka, Takashi; Kataza, Hirokazu; Aoki, Tsutomu; Doi, Mamoru; Kato, Natsuko M.; Kawara, Kimiaki; Kitagawa, Yutaro; Kohno, Kotaro; Konishi, Masahiro; Koshida, Shintaro; Minezaki, Takeo; Morokuma, Tomoki; Motohara, Kentaro; Soyano, Takao; Takahashi, Hidenori; Tamura, Yoichi; Tanabé, Toshihiko; Tanaka, Masuo; Tarusawa, Ken'ichi; Tateuchi, Ken; Todo, Soya; Yoshii, Yuzuru

    2014-07-01

    The MIMIZUKU is the first-generation mid-infrared instrument for the TAO 6.5-m telescope. It challenges to prove the origin of dust and the formation of planets with its unique capabilities, wide wavelength coverage and precise calibration capability. The wide wavelength coverage (2-38 ?m) is achieved by three switchable cameras, NIR, MIR-S, and MIR-L. The specifications of the cameras are revised. A 5?m-cutoff HAWAII-1RG is decided to be installed in the NIR camera. The optical design of the MIR-L camera is modified to avoid detector saturation. Its final F-number is extended from 5.2 to 10.5. With these modifications, the field of view of the NIR and MIR-L camera becomes 1.2' × 1.2' and 31" × 31", respectively. The sensitivity of each camera is estimated based on the revised specifications. The precise calibration is achieved by the "Field Stacker" mechanism, which enables the simultaneous observation of the target and the calibration object in different fields. The up-and-down motion of the cryostat (~ 1 t), critical for the Field Stacker, is confirmed to have enough speed (4 mm/s) and position accuracy (~ 50 ?m). A control panel for the Field Stacker is completed, and its controllers are successfully installed. The current specifications and the development status are reported.

  10. Regional Vegetation Dynamics and Its Response to Climate Change—A Case Study in the Tao River Basin in Northwestern China

    NASA Astrophysics Data System (ADS)

    Qi, J.; Li, C.

    2014-12-01

    Stretching across the eastern Tibetan Plateau and the southwestern Loess Plateau, the Tao River Basin (TRB) is an ideal ecosystem to study eco-hydrological processes in a contiguous landscape but climatically different schemes. In this study, we used the normalized-difference vegetation index (NDVI) data, derived from AVHRR/MODIS satellite sensors, to quantify the regional vegetation dynamic changes in the TRB and determine the key climatic factors driving these changes in the past 30 years through principal component and correlation analyses. We then developed regression models to predict NDVI changes as a function of the climatic factors. Using Sen's slope trend analysis of the climatic data and the regression models we examined how terrestrial vegetation has responded to regional climate change in the TRB. The regression results showed the average winter base NDVI values of 0.14 and 0.04 in the eastern Tibetan Plateau and the southwestern Loess Plateau, respectively. Primarily driven by increasing temperature, the vegetation growth has generally been enhanced since 1981; the spring NDVI increased by 0.03 every 10 years in the eastern Tibetan Plateau, and 0.02/10 years in the southwestern Loess Plateau. The Sen's slope trend analyses showed that the vegetation growing season in the eastern Tibetan Plateau shifted to an earlier start and earlier end, but in contrast the southwestern Loess Plateau experienced an earlier start but later end. The precipitation threshold for vegetation germination is a cumulative spring rainfall of 44 mm; less than this precipitation indicates a spring drought and less vegetation growth.

  11. Improved textured La 2Zr 2O 7 buffer on La 3TaO 7 seed for all-MOD Buffer/YBCO coated conductors

    NASA Astrophysics Data System (ADS)

    Parans Paranthaman, M.; Bhuiyan, M. S.; Sathyamurthy, S.; Heatherly, L.; Cantoni, C.; Goyal, A.

    2008-09-01

    The overall purpose of this research is to develop a potentially low-cost, high throughput, high yield, manufacturing process for buffer deposition, and to gain a fundamental understanding of buffer layers required for an all metal-organic deposition (MOD) based chemical solution approach. This understanding is critical to the development of a reliable, robust, low-cost, long-length manufacturing process of 2G wires. The standard RABiTS architectures consists of a starting template of biaxially textured Ni-W (5 at.%) substrate with a seed layer of Y 2O 3, a barrier layer of YSZ, and a CeO 2 cap. In this three-layer architecture, all the buffers are deposited using reactive sputtering. We have recently demonstrated that the barrier properties and the performance of MOD La 2Zr 2O 7 (LZO) match that of sputtered YSZ layers. In this work, the texture of MOD LZO was also improved by inserting a sputtered Y 2O 3 seed layer on which LZO grows without any degradation of texture. Significant improvement in the texture of sputtered Y 2O 3 seeds on NiW substrates is usually observed which is then transferred to the LZO layer. A key challenge for an all-solution approach is to replace the sputtered seed layer with a possible MOD seed layer with improved texture and on which no degradation of LZO texture occurs. Very recently, we have grown MOD La 3TaO 7 (LTO) seeds directly on biaxially textured Ni-W (3 at.%) with improved texture. In this study, we report a systematic investigation of the growth MOD LZO barrier layer on MOD LTO seeds. Preliminary results show that it is possible to grow MOD LZO with improved texture on MOD LTO seeds. This approach could be potentially used for future all MOD buffer/YBCO coated conductors.

  12. Validation of the NASA GEWEX-SRB Radiation Data over the Tropical Oceans: Comparisons with PIRATA, RAMA, TAO and WHOI Buoy Observations

    NASA Astrophysics Data System (ADS)

    Zhang, T.; Stackhouse, P. W.; Gupta, S. K.; Cox, S. J.; Mikovitz, J. C.

    2013-12-01

    The NASA/GEWEX SRB (Global Energy and Water Exchanges, Surface Radiation Budget) project produces and archives shortwave and longwave radiation budget flux estimates at the top of the atmosphere and at the Earth's surface. The latest version in the archive, Release 3.0, is available as 3-hourly, 3-hourly-monthly, daily and monthly means continuously over the period from July 1983 to December 2007 on a quasi-equal-area grid system of 44016 grid boxes. SRB Release 4 with further improvements in data quality and higher spatial resolution is being developed. The SRB shortwave/longwave fluxes at the Earth's surface from the algorithm GSW(V3.0)/GLW(V3.1) have been extensively validated against high-quality ground-based observations, in particular observed data from the Baseline Surface Radiation Network (BSRN). Comparisons with nearly 6000 site-months of both shortwave and longwave data from 52 BSRN sites show generally good agreement. In addition, the GEWEX SRB data have also been found to compare favorably with the World Radiation Data Centre (WRDC) data and the Global Energy Balance Archive (GEBA) data. In spite of the fact that the BSRN sites are scattered on all seven continents, the validation of the SRB data over the vast oceans had not been done until recently. In this paper, we present comparisons of the GEWEX-SRB data shortwave/longwave data with observations made on arrays moored in tropical oceans. Specifically, we have data from 21 buoys, or moorings, from Prediction and Research Moored Array in the Atlantic (PIRATA), 14 buoys from the Research Moored Array for African-Asian-Australian Monsoon Analysis and Prediction (RAMA) in the Indian Ocean, 20 buoys from the Tropical Atmosphere Ocean (TAO) array in the Pacific, and 3 buoys from the Woods Hole Oceanographic Institute (WHOI) (2 in the Pacific and 1 in the Atlantic). The data from these buoys span 12 years from 2000 to 2011, though not necessarily continuously. It is found that except for occasional outliers, the majority of the comparable pairs of data points agree well. For instance, the bias/RMS from 1644 monthly mean data points is 11.1/19.0 W m-2. Further examination of the outliers is necessary to determine whether they can be attributed to wind-driven tilt and/or aerosol accumulation on the instruments. In order to see how the ocean-based validation compares with land-based validation, we made SRB-BSRN monthly mean shortwave/longwave radiation comparisons in the tropical region only, where all the buoys are moored. The results show that in the case of shortwave radiation, the bias error from the ocean-based validation is somewhat larger than its land-based counterpart, but their RMS errors are not significantly different. In the case of longwave radiation, the ocean-based and land-based validations show nearly identical comparison statistics.

  13. Validation of the NASA GEWEX-SRB Radiation Data over the Tropical Oceans: Comparisons with PIRATA, RAMA, TAO and WHOI Buoy Observations

    NASA Astrophysics Data System (ADS)

    Zhang, T.; Stackhouse, P. W., Jr.; Gupta, S. K.; Cox, S. J.; Mikovitz, J. C.; NASA Gewex Srb Project Team

    2013-05-01

    The NASA GEWEX-SRB (Global Energy and Water Exchanges - Surface Radiation Budget) project produces and archives shortwave and longwave radiation budget data at the top of the atmosphere and the Earth's Surface. The latest version in the archive, Release 3.0, is available as 3-hourly, 3-hourly-monthly, daily and monthly means continuously over the period from July 1983 to December 2007 on a quasi-equal-area grid system of 44016 grid boxes. Releases 4 and 5 with further improved quality and higher spatial resolution are being planned. The SRB shortwave/longwave fluxes at the Earth's surface from the algorithm GSW(V3.0)/GLW(V3.1) have been extensively validated against high-quality ground-based observations, in particular observed data from the Baseline Surface Radiation Network (BSRN). Comparisons with nearly 6000 site-months of both shortwave and longwave data from 52 BSRN sites show generally good agreement. In addition, the GEWEX SRB data have also been found to compare favorably with the World Radiation Data Centre (WRDC) data and the Global Energy Balance Archive (GEBA) data. In spite of the fact that the BSRN sites are scattered on all seven continents, the validation of the SRB data over the vast oceans had not been done until recently. In this paper, we present comparisons of the GEWEX-SRB data shortwave/longwave data with observations made on arrays moored in tropical oceans. Specifically, we have data from 21 buoys, or moorings, from Prediction and Research Moored Array in the Atlantic (PIRATA), 14 buoys from the Research Moored Array for African-Asian-Australian Monsoon Analysis and Prediction (RAMA) in the Indian Ocean, 20 buoys from the Tropical Atmosphere Ocean (TAO) array in the Pacific, and 3 buoys from the Woods Hole Oceanographic Institute (WHOI) (2 in the Pacific and 1 in the Atlantic). The data from these buoys span 12 years from 2000 to 2011, though not necessarily continuously. It is found that except for occasional outliers, the majority of the comparable pairs of data points agree well. Further examination of the outliers is necessary to determine whether they can be attributed to wind-driven tilt and/or aerosol accumulation on the instruments. In order to see how the ocean-based validation compares with land-based validation, we made SRB-BSRN monthly mean shortwave/longwave radiation comparisons in the tropical region only, the region in which all the buoys are moored. The results show that in the case of shortwave radiation, the bias error from the ocean-based validation is somewhat larger than its land-based counterpart, but their RMS errors are not significantly different. In the case of longwave radiation, the ocean-based and land-based validations show nearly identical comparison statistics.

  14. The Tao of Whole Language.

    ERIC Educational Resources Information Center

    Zola, Meguido

    1989-01-01

    Uses the philosophy of Taoism as a metaphor in describing the whole language approach to language arts instruction. The discussion covers the key principles that inform the whole language approach, the resulting holistic nature of language programs, and the role of the teacher in this approach. (16 references) (CLB)

  15. Reconstruction of the 1997/1998 El Nino from TOPEX/POSEIDON and TOGA/TAO Data Using a Massively Parallel Pacific-Ocean Model and Ensemble Kalman Filter

    NASA Technical Reports Server (NTRS)

    Keppenne, C. L.; Rienecker, M.; Borovikov, A. Y.

    1999-01-01

    Two massively parallel data assimilation systems in which the model forecast-error covariances are estimated from the distribution of an ensemble of model integrations are applied to the assimilation of 97-98 TOPEX/POSEIDON altimetry and TOGA/TAO temperature data into a Pacific basin version the NASA Seasonal to Interannual Prediction Project (NSIPP)ls quasi-isopycnal ocean general circulation model. in the first system, ensemble of model runs forced by an ensemble of atmospheric model simulations is used to calculate asymptotic error statistics. The data assimilation then occurs in the reduced phase space spanned by the corresponding leading empirical orthogonal functions. The second system is an ensemble Kalman filter in which new error statistics are computed during each assimilation cycle from the time-dependent ensemble distribution. The data assimilation experiments are conducted on NSIPP's 512-processor CRAY T3E. The two data assimilation systems are validated by withholding part of the data and quantifying the extent to which the withheld information can be inferred from the assimilation of the remaining data. The pros and cons of each system are discussed.

  16. [Stickler's syndrome or hereditary progressive arthro-ophthalmopathy].

    PubMed

    De la Chapelle, A C; Manouvrier, S; Dubos, J P; Farriaux, J P

    1988-01-01

    A case of Stickler's syndrome is reported. This syndrome associates eye defects, craniofacial and musculo-skeletal abnormalities, sensori-neural hearing loss and mitral-valve prolapse. It is an autosomal dominant disorder probably resulting from a connective tissue dysplasia. There is a major risk for the occurrence of serious ocular problems (blindness), and ophthalmologic follow-up has to be performed on affected persons and relatives in order to improve the long term prognosis. PMID:3419872

  17. Thyroid-like ophthalmopathy in a euthyroid patient receiving Ipilimumab.

    PubMed

    McElnea, Elizabeth; Ní Mhéalóid, Aine; Moran, Sarah; Kelly, Rory; Fulcher, Tim

    2014-12-01

    A 68-year-old lady with metastatic malignant melanoma was treated with Ipilimumab. She presented to Eye Casualty unable to move her eyes. Physical examination confirmed ophthalmoplegia and identified proptosis bilaterally. Radiological imaging showed bilateral enlargement of all the extra-ocular muscles suggestive of thyroid eye disease. Laboratory investigations found this patient to be euthyroid. A diagnosis of thyroid-like orbitopathy secondary to Ipilimumab therapy was made. Thyroid function tests should be performed for all patients prior to their commencement of Ipilimumab. Thyroid-like eye disease may develop in patients treated with Ipilimumab even if they remain euthyroid. PMID:25207976

  18. Graves' ophthalmopathy following external neck irradiation for nonthyroidal neoplastic disease

    Microsoft Academic Search

    R. D. Wasnich; F. C. Grumet; R. O. Payne; J. P. Kriss

    1973-01-01

    BS>radiation during childhood. Although goiters with nodules were ; relatively few, those also tended to occur in exposed women. Levels of serum ; thyrotropin were not correlated with the prevalence of goiter, nor were they ; related to atomic bomb exposure. Small but significantly increased levels were ; found in women, as compared with men. Atomic bomb survivors appear to

  19. TAOS: Testing with Analysis and Oracle Support

    Microsoft Academic Search

    Debra J. Richardson

    1994-01-01

    Few would question that software testing is a necessary activity for assuring software quality, yet the typical testing process is a human intensive activity and as such, it is unproductive, error-prone, and often inadequately done. Moreover, testing is seldom given a prominent place in software development or maintenance processes, nor is it an integral part of them. Major productivity and

  20. Tao Probing the End of the World

    E-print Network

    Sung-Soo Kim; Masato Taki; Futoshi Yagi

    2015-06-25

    We introduce a new IIB 5-brane description for the E-string theory which is the world-volume theory on M5-brane probing the end of the world M9-brane. The E- string in the new realization is depicted as spiral 5-branes web equipped with the cyclic structure which is a key to uplifting to 6 dimensions. Utilizing the topological vertex to the 5-brane web configuration enables us to write down a combinatorial formula for the generating function of the E-string elliptic genera, namely the full partition function of topological strings on local 1/2 K3 surface.

  1. Graves' Disease

    MedlinePLUS

    ... is called Graves’ ophthalmopathy (GO). [ Top ] What is Graves’ ophthalmopathy? Graves’ ophthalmopathy is a condition associated with Graves’ disease that ... may also have bulging eyes, a condition called Graves’ ophthalmopathy (GO). Graves’ disease is most often treated with ...

  2. An Exploration of Formalized Information Retrieval Heuristics Hui Fang, Tao Tao, and ChengXiang Zhai

    E-print Network

    Zhai, ChengXiang

    (Robertson and Sparck Jones, 1976; van Rijbergen, 1977; Turtle and Croft, 1991; Fuhr, 1992; Ponte and Croft, 1998; Lafferty and Zhai, 2003), and logic-based models(van Rijsbergen, 1986; Wong and Yao, 1995; Fuhr, 2001

  3. An Exploration of Formalized Information Retrieval Heuristics Hui Fang, Tao Tao, and ChengXiang Zhai

    E-print Network

    Zhai, ChengXiang

    (Robertson and Sparck Jones, 1976; van Rijbergen, 1977; Turtle and Croft, 1991; Fuhr, 1992; Ponte and Croft, 1998; Lafferty and Zhai, 2003), and logic­based models(van Rijsbergen, 1986; Wong and Yao, 1995; Fuhr, 2001

  4. Clinical features of hereditary progressive arthro-ophthalmopathy (Stickler syndrome): A survey

    Microsoft Academic Search

    Gunnar B. Stickler; Wendy Hughes; Pat Houchin

    2001-01-01

    Purpose: To define variations in the clinical manifestations of Stickler syndrome. Methods: A questionnaire was sent to 612 persons. Results: Of the 316 usable replies, 95% of persons had eye problems (retinal detachment occurred in 60% of patients, myopia in 90%, and blindness in 4%); 84% had problems with facial structures such as a flat face, small mandible, or cleft

  5. Tao Rising: Sexism and Feminist/Transpersonal Therapy.

    ERIC Educational Resources Information Center

    Sawyer, Llewlee L.

    This report presents a dialectical model of identity development which is based on observations of how the self evolves within the context of feminist/transpersonal therapy. Developmental stages which are identified include fusion (Stage I), differentiation (Stage II), and integration (Stage III) of the Child (asserting) and Parent (nurturing)…

  6. Compressive Sensing (CS) [Cands/Romberg/Tao, Donoho, 2005

    E-print Network

    · Compressive measurements obtained individually by each sensor - reduced communication requirement Joint common and innovations J signals of length N individual measurements Single Matrix/Vector Representation location matrices: Example: Sparse common and innovations Bipartite Graph Formulation Quantifying

  7. Learning To Teach at the Elbows: The Tao of Teaching.

    ERIC Educational Resources Information Center

    MacKinnon, Allan

    1996-01-01

    The dialogical relationship between Confucianism and Taoism serves as a framework for examining the interplay between learning as socioculturally mediated activity and critical reflection in preservice teacher education. Article highlights a summer elementary school science program that involves preservice teachers, university faculty, and a local…

  8. Human Carrying Status in Visual Surveillance Dacheng Tao1

    E-print Network

    Maybank, Steve

    and these sequences were important evidence for agencies fighting against international terrorism. Figure 1: (http external world. The human gait not only produces a distinctive moving silhouette but also reflects. For a recognition problem, features and classification stand as two convex mirrors each reflecting and amplifying

  9. Towards a Better Forecasting Model for Economic Jing Tao YAO

    E-print Network

    Yao, JingTao

    financial time series. Neural network based financial forecasting has been explored for about a decade. Many a study of neural network forecasting construction system. Forecasting, especially financial forecasting to the outputs. Data are partitioned into several sets to find out the particular knowledge of this time series

  10. Continuous Nearest Neighbor Search Yufei Tao Dimitris Papadias Qiongmao Shen

    E-print Network

    Shahabi, Cyrus

    .g., find the three NN of a point q in P), and closest pair queries [HS98, CMTV00] (e.g., find the k closest}@cs.ust.hk Abstract A continuous nearest neighbor query retrieves the nearest neighbor (NN) of every point on a line segment (e.g., "find all my nearest gas stations during my route from point s to point e"). The result

  11. On Anti-Corruption Privacy Preserving Publication Yufei Tao 1

    E-print Network

    Zhang, Donghui

    privacy disclosure in the presence of corruption. Motivated by this, we advocate an alternative patient. Second, the released content should permit a researcher to understand the correlations between Disease and the other attributes, which are statistically significant in a large number of patients

  12. 75 FR 71414 - Questa Ranger District, Carson National Forest; Taos County, NM; Taos Ski Valley's 2010 Master...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-23

    ...to better accommodate traffic circulation and pedestrian access to the base area. The Bear and Bison lots would be reconfigured to allow the Bison lot to become a thoroughfare. --Constructing an extra parking bay north of the Armadillo...

  13. Presence of Dry Eye in Patients with Hashimoto's Thyroiditis

    PubMed Central

    K?l?çkan, Elif; Ecemi?, Gulçin; Beyazyildiz, Emrullah; Çolak, Ramis

    2014-01-01

    Purpose. To evaluate the tear function tests in patients with Hashimoto's thyroiditis and to compare the results with healthy subjects. Methods. A hundred and ten patients with Hashimoto's thyroiditis and 100 healthy subjects were included in this study. The presence of thyroid-associated ophthalmopathy and tear function tests were evaluated clinically. The results were first compared between the patients and the control groups and then compared between patients with NOSPECS and patients without NOSPECS. Logistic regression analyses of the risk factors for dry eye including sex, gender, free plasma thyroxine, proptosis, upper eyelid margin-reflex distance, and duration of the disease were also evaluated. Results. The mean ocular surface disease index score was significantly higher and mean Schirmer and mean tear break-up time scores were significantly lower in patients compared to control subjects. Mean Schirmer and tear break-up time scores were found to be significantly lower in patients with NOSPECS when compared to the patients without NOSPECS. Both proptosis and free plasma thyroxine levels were significantly associated with dry eye. Conclusions. Patients with Hashimoto's thyroiditis tend to develop dry eye more common than healthy subjects. Proptosis and lower free plasma thyroxine levels were found to be risk factors for the presence of dry eye. PMID:25580281

  14. Localization of the human 64kD autoantigen D1 to myofibrils in a subset of extraocular muscle fibers

    NASA Technical Reports Server (NTRS)

    Conley, C. A.; Fowler, V. M.

    1999-01-01

    PURPOSE. To evaluate the tissue-specific expression pattern of the 64kD human autoantigen D1, a tropomodulin-related protein that may be involved in thyroid-associated ophthalmopathy. METHODS. Recombinant 64kD human autoantigen D1 was generated in a bacterial expression system and used to immunize rabbits. Specific antibodies were affinity-purified and used for Western blots on normal and hyperthyroid rat and rabbit tissue, and immunofluorescence localization on cryosections of rat tissue. RESULTS. Anti-64kD human autoantigen D1 antibodies recognize specifically a approximately 70kD polypeptide in western blots of extraocular muscle, sternothyroid muscle, and smooth muscle. Immunofluorescence staining demonstrates that the 64kD human autoantigen D1 localizes to myofibrils in slow fibers from rat extraocular and sternothyroid muscle. The level of this protein is not altered in extraocular muscles from hyperthyroid rabbits. CONCLUSIONS. The 64kD human autoantigen D1 is expressed in slow fibers of extraocular and sternothyroid muscles as a component of myofibrils, and is not upregulated in conditions of hyperthyroidism.

  15. Genetics Home Reference: Graves disease

    MedlinePLUS

    ... disease have eye abnormalities, which are known as Graves ophthalmopathy. These eye problems can include swelling and inflammation, ... Studies suggest that immune system abnormalities also underlie Graves ophthalmopathy and pretibial myxedema. People with Graves disease have ...

  16. Rfrences : Adenis J. P., Robert P. Y., 1994. Dcompression orbitaire selon la technique d'Olivari. J. Fr.

    E-print Network

    Paris-Sud XI, Université de

    of Graves' ophthalmopathy (clinical review 13). J. Clin. Endocrimol.Metab., 71(3): 559-563. Bartley G. B., Gorman C. A., 1995. Diagnostic criteria for Graves' ophthalmopathy. Am. J. Ophthalmol., 119: 792 on Telemedicine, Gothenburg, Sweden. Burch H. B., Wartofsky L., 1993. Graves' ophthalmopathy: current concepts

  17. Quantifying Contextual Information for Object Detection Wei-Shi Zheng, Shaogang Gong and Tao Xiang

    E-print Network

    Gong, Shaogang

    ). Consequently, there are Scene-Thing [15], Stuff-Stuff [22], Thing-Thing [18], and Thing-Stuff [12] context of con- text including Thing-Thing, Thing-Stuff, and Thing-Scene contexts. 2) More does not necessarily the terminology in [12], objects can be put into two categories: monolithic objects or "things" (e.g. cars

  18. Coalition Formation and Trust in Collaborative Control John S. Baras, Tao Jiang and Pedram Hovareshti

    E-print Network

    Baras, John S.

    Hovareshti Department of Electrical and Computer Engineering and Institute for Systems Research University analyze the tradeoff between the benefits of collaboration and these constraints (or costs are used as models for many phenomena and situations in science and engineering: com- munication networks

  19. Human Pose Estimation Using Structural Support Vector Machines Ke Chen, Shaogang Gong and Tao Xiang

    E-print Network

    Gong, Shaogang

    School of Electronic Engineering and Computer Science Queen Mary University of London London E1 4NS estimation problem on cluttered images from the benchmarking Buffy the Vampire Slayer dataset and the highly

  20. A VARIATION NORM CARLESON THEOREM RICHARD OBERLIN ANDREAS SEEGER TERENCE TAO

    E-print Network

    Seeger, Andreas

    for the Fourier series, (1) Snf(x) S[f](n, x) = n k=-n fk e2ikx ; here n N0 = {0, 1, 2, . . . }. The celebrated theorem by Carleson [4] states that if f is square integrable then Snf converges to f almost everywhere |Snf| Lp(T) C f Lp(T) for all f Lp(T); see also [10], [20], and [12] for other proofs of this fact

  1. doi: 10.3319/TAO.2010.12.13.01(T) * Corresponding author

    E-print Network

    Wu, Yih-Min

    , Taiwan Earthquake Sequence Hsin-Hua Huang1 , Yih-Min Wu1, * , Ting-Li Lin1 , Wei-An Chao1 , J. Bruce H. Wu, T. L. Lin, W. A. Chao, J. B. H. Shyu, C. H. Chan, and C. H. Chang, 2011: The preliminary study Bu- reau (CWB) rapid reporting system (Wu et al. 1997, 2002) and named the "2010 Jiasian earthquake

  2. doi: 10.3319/TAO.2013.05.30.01(T) * Corresponding author

    E-print Network

    Wu, Yih-Min

    , Taiwan Earthquake Chi-Hsuan Chen1, 2 , Hsin-Hua Huang1 , Wei-An Chao1 , Yih-Min Wu1, * , and Chien, Y. M. Wu and C. H. Chang, 2013: Re-examining source parameters of the 2012 Wutai, Taiwan earthquake ) in Taiwan (Wu et al. 2003a). The Taiwan High Speed Rail and the Kaohsiung Metro system were temporally

  3. doi: 10.3319/TAO.2014.03.27.01(T) * Corresponding author

    E-print Network

    Wu, Yih-Min

    for Producing Quick Shaking Maps in Taiwan Chih-Yih Hsieh1 , Yih-Min Wu1, * , Tai-Lin Chin2 , Kuan-Hung Kuo1 , Da-Yi Chen1, 3 , Kai-Shyr Wang4 , Ya-Ting Chan1 , Wen-Yen Chang5 , Wei-Sen Li6 , and Shaw-Hsung Ker6: Earthquake, Damage earthquake, Shaking map, MEMS accelerometer Citation: Hsieh, C. Y., Y. M. Wu, T. L. Chin

  4. SoK: Eternal War in Memory Laszlo Szekeres, Mathias Payer, Tao Wei, Dawn Song

    E-print Network

    Sekar, R.

    University University of California, Berkeley Peking University Abstract--Memory corruption bugs in software exploits show that all currently deployed protections can be defeated. This paper sheds light. INTRODUCTION Memory corruption bugs are one of the oldest problems in computer security. Applications written

  5. A Real-Time Distributed Hash Table Tao Qian, Frank Mueller

    E-print Network

    Mueller, Frank

    with such a distributed PDC architecture. In today's power grid, real-time control actuation relies in part on the grid power grid uses a centralized system to monitor and control wide-area power grid states. This centralized architecture is becoming a bottleneck as large numbers of wind and photo-voltaic (PV) generation

  6. doi: 10.3319/TAO.2013.05.23.01(Oc) * Corresponding author

    E-print Network

    Wu, Chau-Ron

    , Chlorophyll and POC Flux in the Southern East China Sea Before and After the Passage of Typhoon Jangmi Yung 10 January 2013, accepted 23 May 2013 ABSTRACT Severe tropical storms play an important role in triggering phytoplankton blooms, yet direct field observation of evidence of the effects of a typhoon is very

  7. TAO: a High-performance ORB Endsystem Architecture for Real-time CORBA

    Microsoft Academic Search

    Douglas C. Schmidt; Aniruddha Gokhale; Timothy H. Harrison; David Levine; Chris Cleeland

    Many application domains (such as avionics, telecommuni- cations, and multimedia) require real-time guarantees from the underlying networks, operating systems, and middle- ware components to achieve their quality of service (QoS) requirements. In addition to providing end-to-end QoS guar- antees, applications in these domains must be flexible and reusable. Requirements for flexibility and reusability moti- vate the use of object-oriented middleware

  8. The TAO of Topic Maps finding the way in the age of infoglut

    Microsoft Academic Search

    Steve Pepper

    2000-01-01

    Topic maps are a new ISO standard for describing knowledge structures and associating them with information resources. As such they constitute an enabling technology for knowledge management. Dubbed \\

  9. Self-adaptive Cloud Capacity Planning Yexi Jiang, Chang-shing Perng, Tao Li, Rong Chang

    E-print Network

    Li, Tao

    the amount of cost savings. But the power supply can be adjusted readily. It is necessary to control service providers. Along with the new business opportunities, the pay-as-you- go model drastically changes an integrated system with intelligent cloud capacity prediction. Considering the unique characteristics

  10. doi: 10.3319/TAO.2011.01.27.01(T) * Corresponding author

    E-print Network

    Hwang, Cheinway

    , ionospheric delay, antenna phase cen- ter variations, GPS satellite and receiver clock errors, cycle slips Around Taiwan Based on GPS Observations Ta-Kang Yeh1, * , Cheinway Hwang2 , Jiu-Fu Huang2 , Benjamin Fong, Hsinchu 300, Taiwan, ROC 3 Institute of Earth Sciences, Academia Sinica, Taipei 115, Taiwan, ROC Received

  11. doi: 10.3319/TAO.2010.05.19.01(TibXS) * Corresponding author

    E-print Network

    Hwang, Cheinway

    @mail.nctu.edu.tw A Preliminary Analysis of Lake Level and Water Storage Changes over Lakes Baikal and Balkhash from Satellite ABStrACt Lakes Baikal and Balkhash are two of the world's major lakes affecting fresh water supplies) and water storage change in these two lakes. At Lake Baikal, the average rate of LLC is negative for 1992

  12. For the Quantum Heisenberg Ferromagnet, Tao to the Proof of a Phase Transition

    E-print Network

    game veterans, sniÆng the quarry, will be ready to join the hunt. The central construct views the trace and believe that readers will be enticed by the naturalness and beauty of the path; some perhaps even, big

  13. For the Quantum Heisenberg Ferromagnet, Tao to the Proof of a Phase Transition

    E-print Network

    Paul Federbush

    2002-02-27

    We present the outline of a proof for the 3-d phase transition which we hope to carry forth. At the same time this paper provides some physical understanding of the phase transition, in the flavor of relatively simple arguments from an undergraduate course. A number of directions for mathematical research, interesting in their own right, will be suggested by aspects of the development. We hope and believe that readers will be enticed by the naturalness and beauty of the path; some perhaps even, big game veterans, sniffing the quarry, will be ready to join the hunt. The central construct views the trace, Tr(exp(-beta*H)), as a lattice gas of polymers, each representing a cycle in the permutation group, with hard core interactions. The activities of the polymers have expressions as arising from the main conjecture of the paper. The estimates lead to a phase transition in 3-d, but not 2-d. This occurs via the same argument that a random walk in 2-d has certain return to the origin, but not so for a random walk in 3-d.

  14. doi: 10.3319/TAO.2008.19.1-2.163(SA) * Corresponding author

    E-print Network

    . IntroductIon Astronomical tides, which are generated by the gravi- tational forces of the moon and the sun components. The amplitudes and phases of the tidal constit- uents are then determined on the basis of known periods that are driven by the astronomical motions of the earth, moon, and sun. However, measured water

  15. Building Scalable and High Efficient Java Multimedia Collaboration Wenjun Wu, Tao Huang, Geoffrey Fox

    E-print Network

    be addressed in a unified and service-oriented framework. Java as a cross-platform programming language on traditional client- server or multicast communication architecture, and make few improvement such as windows, Linux and Mac OSX, integrates audio and video collaboration together (compared to Access Grid

  16. Conductance Titration of Single-Peptide Molecules Xiaoyin Xiao, Bingqian Xu, and Nongjian Tao*

    E-print Network

    Zhang, Yanchao

    substrate in a buffer containing 1 mM of the sample molecules (Figure 1a).9 The experiment was controlled transducer (PZT). Once the contact was fully established, the feedback loop activated the PZT to pull

  17. doi: 10.3319/TAO.2013.01.22.01(T) * Corresponding author

    E-print Network

    Wu, Yih-Min

    the Eurasian and Philip- pine Sea Plates, many devastating earthquakes have taken place in Taiwan (Wang and Shin 1998; Hsu 2003; Wu et al. 2008; Cheng et al. 2012). The Chiayi region, located in southwestern

  18. A Faster Algorithm for Generalized Multiple-Instance Learning Qingping Tao Stephen D. Scott

    E-print Network

    Scott, Stephen D.

    learning algorithm for this model required significant time and memory to run. Here we present and empirically evaluate a new algorithm, testing it on data from drug discovery and content-based image retrieval, but requires much less computation time and memory. Introduction In multiple-instance learning (MIL), each

  19. The design of the TAO real-time object request broker

    Microsoft Academic Search

    Douglas C. Schmidt; David L. Levine; Sumedh Mungee

    1998-01-01

    Many real-time application domains can benefit from flexible and open distributed architectures, such as those defined by the CORBA specification. CORBA is an architecture for distributed object computing being standardized by the OMG. Although CORBA is well-suited for conventional request\\/response applications, CORBA implementations are not yet suited for real-time applications due to the lack of key quality of service (QoS)

  20. THE GREEN-TAO THEOREM ON ARITHMETIC PROGRESSIONS IN THE PRIMES: AN ERGODIC POINT OF VIEW

    Microsoft Academic Search

    BRYNA KRA

    2006-01-01

    A long-standing and almost folkloric conjecture is that the primes contain arbitrarily long arithmetic progressions. Until recently, the only prog- ress on this conjecture was due to van der Corput, who showed in 1939 that there are infinitely many triples of primes in arithmetic progression. In an amazing fusion of methods from analytic number theory and ergodic theory, Ben Green

  1. The Tao of Supervision: Taoist Insights into the Theory and Practice of Educational Supervision.

    ERIC Educational Resources Information Center

    Glanz, Jeffrey

    1997-01-01

    There are three approaches to educational supervision: the applied science approach, the interpretive-practical approach, and the critical/emancipatory approach. From a Taoist perspective, conflicting supervision theories or proposals should be welcomed, not resisted. By accepting a diversity of views to inform practice, a balance or centeredness…

  2. Materials Data on NaSr3TaO6 (SG:167) by Materials Project

    SciTech Connect

    Kristin Persson

    2014-11-02

    Computed materials data using density functional theory calculations. These calculations determine the electronic structure of bulk materials by solving approximations to the Schrodinger equation. For more information, see https://materialsproject.org/docs/calculations

  3. Materials Data on NaLa2TaO6 (SG:14) by Materials Project

    SciTech Connect

    Kristin Persson

    2014-11-02

    Computed materials data using density functional theory calculations. These calculations determine the electronic structure of bulk materials by solving approximations to the Schrodinger equation. For more information, see https://materialsproject.org/docs/calculations

  4. MED263: Bioinformatic Applications to Human Disease W. Andy Tao, University of Purdue

    E-print Network

    Gleeson, Joseph G.

    , 1999. 20(10): p. 2100-10. 8. Stulik, J, et al., Overexpression of calcium-binding protein calgranulin B Spectrometry) LC 1) reverse phase column used to reduce sample complexity. 2) typically a series of fractions;Peirce Protein Research Products: link Quantitation #12;SILAC (stable isotope labeling by amino acids

  5. Guidelines for Financial Forecasting with Neural Networks JingTao YAO

    E-print Network

    Yao, JingTao

    . We will discuss a seven-step neural network forecasting model building approach in this article. Pre and post data processing/analysis skills, data sampling, training criteria and model recommendation the observed movements. For instance, the forecasting of stock prices can be described in this way. Assume

  6. Materials Data on Y3TaO7 (SG:20) by Materials Project

    SciTech Connect

    Kristin Persson

    2014-11-02

    Computed materials data using density functional theory calculations. These calculations determine the electronic structure of bulk materials by solving approximations to the Schrodinger equation. For more information, see https://materialsproject.org/docs/calculations

  7. Thyroid Disease

    MedlinePLUS

    ... American Thyroid Association. (2014). Thyroid nodules . Rahib, L., Smith, B. D., Aizenberg, R., Rosenzweig, A. B., Fleshman, ... American Thyroid Association. (2014). Thyroid nodules . Rahib, L., Smith, B. D., Aizenberg, R., Rosenzweig, A. B., Fleshman, ...

  8. How well can wavelet denoising improve the accuracy of computing fundamental Qi Li Tao Li, Shenghuo Zhu Chandra Kambhamettu

    E-print Network

    Delaware, University of

    denoising technique in image processing, we study the interesting question: how well wavelet denoising can in computer vision as well as in image processing. Keyword: Wavelet denoising, fundamental matrix, residue data [6, 8, 4]. Image processing researchers have already witnessed successes of wavelet denoising

  9. Fabrication approach for molecular memory arrays Chao Li, Daihua Zhang, Xiaolei Liu, Song Han, Tao Tang, and Chongwu Zhoua)

    E-print Network

    Zhou, Chongwu

    the SAM off this electrode and expos- ing the gold. To make top contacts and interconnects to the self-assembled to confirm the formation of the self-assembled monolayer SAM . An atomic force microscope AFM and interconnect molecular wires assembled on electrode arrays in crossbar architectures. Using this simple

  10. TAO, Vol. 16, No. 5, 1097-1120, December 2005 Characteristic Trace Fossils from Shoreface to Offshore Environments

    E-print Network

    Chen, Wen-Shan

    -upward to coarsening-upward sequence can be divided into five lithofacies and five ichnocoenoses. Ichnocoenoses. The sequential variation in lithofacies and ichnofossil assem- blages coincides with changes in Early Oligocene

  11. ANIR: Infrared-Optical Simultaneous Imager for miniTAO 1 m Telescope at an Altitude of 5640 m

    SciTech Connect

    Motohara, Kentaro; Konishi, Masahiro; Mitani, Natsuko; Sako, Shigeyuki; Uchimoto, Yuka K.; Toshikawa, Koji; Minezaki, Takeo; Tanabe, Toshihiko; Miyata, Takashi; Koshida, Shintaro; Nakamura, Tomohiko; Asano, Kentaro; Yoshii, Yuzuru; Doi, Mamoru; Kohno, Kotaro; Tanaka, Masuo; Kawara, Kimiaki; Handa, Toshihiro [Institute of Astronomy, University of Tokyo, Osawa 2-21-1, Mitaka, Tokyo 181-0015 (Japan); Ohsawa, Ryou; Umeda, Hideyuki [Department of Astronomy, University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033 (Japan)

    2010-10-15

    Early follow-up observations of gamma-ray bursts (GRBs) in wide wavelength range, especially from the optical to the near infrared (NIR) bands, are crucial for search of high-redshift GRBs by detecting their Lyman limit break. For this purpose, we have developed a NIR/optical simultaneous imager called ANIR (Atacama Near InfraRed camera) for the University of Tokyo Atacama 1.0 m telescope. Installed at the summit of Co. Chajnantor (5640 m altitude) in northern Chile, this telescope is the world's highest optical/NIR observatory. ANIR saw the first light in June 2009, and several observing runs have been carried out for performance verification as well as scientific observations. During the run, we have successfully detected an optical/NIR afterglow of GRB091018. Thanks to the excellent seeing (median {approx}0''.8), 5{sigma} limiting magnitudes reach 23.3, 20.6, and 20.8 mag(AB) in the B, J and Ks bands, respectively, with 600 sec exposure.

  12. IMPLEMENTATION OF THE DAUM-HUANG EXACT-FLOW PARTICLE FILTER Tao Ding and Mark J. Coates

    E-print Network

    Coates, Mark

    computational cost) is al- lowed to grow exponentially with the state dimension [3]. Daum and Huang introduced and observation noises are Gaussian, the system map is linear, but the ob- servations are highly non-linear. We-filter implementation described in [10] performs relatively poorly. We introduce a modified imple- mentation

  13. The Dissertation Committee for Tao Li Certifies that this is the approved version of the following dissertation

    E-print Network

    John, Lizy Kurian

    ;Acknowledgements In my research, I have received assistance from many people. First, I would like to thank my as all of her other students, have had the financial support we need to accomplish our goals. I am grateful to her for the freedom and flexibility she gave me throughout my Ph. D. study. My gratitude goes

  14. TAO, Vol. 15, No. 5, 949-981, December 2004 Simulations of Asian Yellow Dust Incursion Over Taiwan

    E-print Network

    picture of the three di- mensional transport patterns. The general characteristics of dust incursion. INTRODUCTION Large-scale dust storms, originating at the northern and northwestern China, frequently occur 2004950 and aviation transportation. These airborne dust particles are often termed yellow dust, min- eral

  15. The Tao of Parallelism in Algorithms Keshav Pingali1,3, Donald Nguyen1, Milind Kulkarni5,

    E-print Network

    Pingali, Keshav K.

    that the dependence graph is not a suitable abstraction for algorithms in new application areas like machine learning and net- work analysis in which the key data structures are "irregular" data structures like graphs, trees network analysis, the key data structures are extremely sparse graphs in which no

  16. Optical transmittance and Raman scattering studies of (K, Na)(Nb, Ta)O3 single crystal

    NASA Astrophysics Data System (ADS)

    Sang, Shijing; Yuan, Zhongyuan; Zheng, Limei; Sun, Enwei; Zhang, Rui; Wang, Junjun; Wang, Rui; Yang, Bin; Liu, Min

    2015-07-01

    The optical properties of KNN-based single crystals were investigated firstly in this work. The optical transmittance of (K0.56Na0.44)(Nb0.77Ta0.23)O3 (KNNT) single crystal was measured at different temperatures. The band gap energies of direct transition Egd, indirect transition Egi, and the phonon energies Ep involved in the indirect transition were calculated based on the optical transmittance spectra. It was found that Egd and Egi show abrupt change at orthorhombic-tetragonal phase transition temperature (TO-T) at 119 °C due to the change of crystal lattice, while Ep varies rapidly at around 60 °C. In order to further understand the phase transition behavior and the assistant phonons in the indirect transition, the KNNT single crystal was characterized by using Raman spectroscopy. It is clarified that the ?1 vibration mode is involved in the indirect transition below 60 °C and ?5 mode is involved above 60 °C. The Raman scattering of KNNT crystal shows distinct behavior in different phases. The phase transitions at TO-T = 119°C and TC = 291 °C can be confirmed respectively as orthorhombic-tetragonal and tetragonal-cubic by the discontinuities of the Raman peaks' intensities and positions.

  17. TAO, Vol. 11, No. 4, 753-764, December 2000 A Rapid Method for the Determination of 137

    E-print Network

    Huh, Chih-An

    - ronments from atomic bomb tests, nuclear accidents, and nuclear waste disposal. As an ele- ment of the Cs can be determined by atomic absorption spectrometry or by gravimetric measurement of H2 PtCl6

  18. TAO, Vol. 15, No. 3, 493-502, September 2004 Statistical Assessment for the Hazard of Large Aftershocks

    E-print Network

    Chen, Yuh-Ing

    -time hazard assessment for large aftershocks from a major earth- quake is usually needed for disaster relief distribution of aftershocks after the Chi-Chi earthquake (M = 7.3, 1999/ 9/21). Both the maximum likelihood-Chi earthquake. (Key words: Aftershock hazard, Bayesian estimate, Conjugate prior distribution, Maximum

  19. QUANTITATIVE CHARACTERIZATION AND EVOLUTION OF NANOSCALE POROSITY Tao Sun, S. Donthu, Arvind Srivastava, Jin Wang, and Vinayak P. Dravid

    E-print Network

    Shull, Kenneth R.

    in understanding gas sensing devices. 0.5 1.0 1.5 2.0 0.5 1.0 1.5 2.0 qy (nm-1) 0.0 0.5 1.0 1.5-1.5 -1.0 -0.5 qz(nm-1)qz(nm-1) qy (nm-1) 0.0 0.5 1.0 1.5-1.5 -1.0 -0.5 Undoped Pd-doped Data Simulation 0.5 1.0 1.5 2.0 0.5 1.0 1.5 2.0 0.5 1.0 1.5 2.0 0.5 1.0 1.5 2.0 0.5 1.0 1.5 2.0 qy (nm-1) 0.0 0.5 1.0 1.5-1

  20. TAO, Vol. 14, No. 3, 1-10, September 2003 Earthquake Clustering Relative to Lunar Phases in Taiwan

    E-print Network

    Lin, Cheng-Horng

    C. H. Lin 1, *, Y. H. Yeh 1 , Y. I. Chen 2 , J. Y. Liu 3 and K. J. Chen 4 (Manuscript received 21 clustering of smaller earthquakes (2.5moon day being about 30% higher in frequency than that on other non-full moon days. These phenomena

  1. Learning High-Level Planning from Text S.R.K. Branavan, Nate Kushman, Tao Lei, Regina Barzilay

    E-print Network

    Barzilay, Regina

    and the granularity of planning primitives. Consider, for example, text describing a virtual world such as Minecraft2- ning algorithms rely on manually-crafted high-level 2 http://www.minecraft.net/ #12;abstractions

  2. Intercomparison of Bulk Aerodynamic Algorithms for the Computation of Sea Surface Fluxes Using TOGA COARE and TAO Data

    Microsoft Academic Search

    Xubin Zeng; Ming Zhao; Robert E. Dickinson

    1998-01-01

    A bulk aerodynamic algorithm is developed for all stability conditions for the computation of ocean surface fluxes. It provides roughness lengths of wind, humidity, and temperature for a wind speed range from 0 to 18 m s1: zo = 0.013u2\\/g + 0.11\\/u and ln(zo\\/zot) = ln(zo\\/zoq) = 2.67Re1\\/4 2.57 as derived using the Tropical Oceans Global Atmosphere (TOGA) Coupled Ocean-Atmosphere

  3. Reconciling Trust and Modularity Goals in Web Hridesh Rajan, Jia Tao, Steve Shaner and Gary T. Leavens

    E-print Network

    Leavens, Gary T.

    are distributed software components, that are decoupled from each other using interfaces with specified functional is to introduce a published interface (often a description written in an XML-based language such as WSDL [2]), for communication between services and clients [1]. By allowing components to be decoupled using a specified

  4. Global Abnormal Behaviour Detection Using a Network of CCTV Cameras Emanuel E. Zelniker, Shaogang Gong, Tao Xiang

    E-print Network

    Paris-Sud XI, Université de

    Global Abnormal Behaviour Detection Using a Network of CCTV Cameras Emanuel E. Zelniker, Shaogang the detection of global abnormal behaviours across a network of CCTV cameras. Although the problem of multiple behaviours of objects monitored by a network of CCTV cameras with disjointed camera views, and no effort has

  5. TAO, Vol. 15, No. 3, 545-562, September 2004 Preliminary Results of the iSTEP Program on Integrated

    E-print Network

    Chen, Yuh-Ing

    be forecast, much of this is due to a lack of predictive capability. The problem of earthquake prediction has on Integrated Search for Taiwan Earthquake Precursors Yi-Ben Tsai 1, *, Jann-Yenq Liu 2,3 , Kuo-Fong Ma 1@geps.gep.ncu.edu.tw The predictability of earthquakes has been a hotly debated question in earthquake science for some time. The answer

  6. TAO, Vol. 14, No. 4, 421-430, December 2003 Relocation of the 1998 Rueyli, Taiwan, earthquake sequence using

    E-print Network

    Wu, Yih-Min

    and theoretical travel time differences are minimized for pairs between closely spaced earthquakes at each station sequence using three-dimensions velocity structure with stations corrections Yih-Min Wu 1 , Chien determination (JHD) and double-difference earthquake loca- tion algorithm (hypoDD), three-dimensions velocity

  7. Reprint from Terrestrial, Atmospheric and Oceanic Sciences TAO, Vol. 8, No. 4, 461-480, December 1997

    E-print Network

    Lin, Andrew Tien-Shun

    imprints throughout the island. On the Chilung Shelf, a series of topographical lineaments extending from onland Taiwan and oriented in the SW-NE direction are present; however, seismic profiles indicate Taiwan has been under a different tectonic stress from that represented on the island. (Key words

  8. Incorporating Semantics in Scientific Workflow Authoring Chad Berkley, Shawn Bowers, Matthew B. Jones, Bertram Ludscher, Mark Schildhauer, Jing Tao

    E-print Network

    Ludäscher, Bertram

    a powerful, cross-domain scientific-workflow authoring environment that allows scientists to design disciplines, while maintaining both generic support for scientific workflows and enabling cross-domain data domain knowledge, but also to support creation of customized user interfaces, thus facilitating cross-domain

  9. Ba(Mg, Ta)O3-BaSnO3 High-Q Dielectric Resonator

    Microsoft Academic Search

    Hiroyuki Matsumoto; Hiroshi Tamura; Kikuo Wakino

    1991-01-01

    Dense ceramics with the chemical formula (1-X)Ba(Mg1\\/3Ta2\\/3)O3-XBaSnO3(X{=}0--0.15) are prepared for use as dielectric resonators. The obtained dielectric constant and Q value for Ba(Mg1\\/3Ta2\\/3)O3 were 24 and 43000 at 10 GHz, respectively. As X increased from 0 to 0.15, the temperature coefficient of resonant frequency decreased gradually from 5.4 to -0.5 ppm\\/°C. At X{=}0.05, the Q value decreased drastically, and at

  10. Characterization and Chemical Properties of Pd-Au Alloy Surfaces Tao Wei, Jinhai Wang, and D. Wayne Goodman*

    E-print Network

    Goodman, Wayne

    has been observed by Auger electron spectroscopy (AES), low-energy ion scattering spectroscopy (LEISS has been studied by infrared reflection-adsorption spectroscopy (IRAS). Geometric (ensemble-ray photoelectron spectroscopy (XPS), X-ray absorption near-edge spectra (XANES), and ultraviolet photo- electron

  11. Optimizing unit test execution in large software programs using dependency analysis

    E-print Network

    Kim, Taesoo

    Tao is a system that optimizes the execution of unit tests in large software programs and reduces the programmer wait time from minutes to seconds. Tao is based on two key ideas: First, Tao focuses on efficiency, unlike ...

  12. Retrobulbar pressures measured during surgical decompression of the orbit

    Microsoft Academic Search

    A J Otto; L Koornneef; M P Mourits; L Deen-van Leeuwen

    1996-01-01

    AIMS\\/BACKGROUND: In Graves' ophthalmopathy the increase in volume of intraocular muscles and fat will cause elevated intraorbital pressure. In order to investigate the pressure levels involved, intraorbital pressure, or retrobulbar pressure (RBP) was measured continuously in orbits of patients with Graves' ophthalmopathy during surgical decompression. METHODS: Retrobulbar pressure was measured before and during surgical decompression using an intraorbitally applied pressure

  13. Mutation in type II procollagen (COL2Al) that substitutes aspartate for glycine [alpha]l-67 and that causes cataracts and retinal detachment: Evidence for molecular heterogeneity in the Wagner Syndrome and the stickler syndrome (Arthro-Ophthalmopathy)

    SciTech Connect

    Koerkkoe, J.; Ritvaniemi, P.; Kiviirikko, K.I.; Ala-Kokko, L. (Univ. of Oulu (Finland)); Haataja, L. (Univ. of Turku (Finland)); Kaeaeriaeinen, H. (Univ. of Helsinki (Finland)); Prockop, D.J. (Jefferson Thomas Jefferson Univ., Philadelphia PA (United States))

    1993-07-01

    A search for mutations in the gene for type II procollagen (COL2A1) was carried out in affected members of a family with early-onset cataracts, lattice degeneration of the retina, and retinal detachment. They had no symptoms suggestive of involvement of nonocular tissues, as is typically found in the Stickler syndrome. The COL2A1 gene was amplified with PCR, and the products were analyzed by denaturing gradient gel electrophoresis. The results suggested a mutation in one allele for exon 10. Sequencing of the fragment demonstrated a single-base mutation that converted the codon for glycine at position [alpha]1-67 to aspartate. The mutation was found in three affected members of the family available for study but not in unaffected members or 100 unrelated individuals. Comparison with previously reported mutations suggested that mutations introducing premature termination codons in the COL2A1 gene are a frequent cause of the Stickler syndrome, but mutations in the COL2A1 gene that replace glycine codons with codons for bulkier amino acid can produce a broad spectrum of disorders that range from lethal chondrodysplasias to a syndrome involving only ocular tissues, similar to the syndrome in the family originally described by Wagner in 1938. 38 refs., 4 figs., 3 tabs.

  14. Disturbances of Modulating Molecules (FOXP3, CTLA-4/CD28/B7, and CD40/CD40L) mRNA Expressions in the Orbital Tissue from Patients with Severe Graves' Ophthalmopathy

    PubMed Central

    Pawlowski, Przemyslaw; Eckstein, Anja; Luczynski, Wlodzimierz; Johnson, Kristian; Kretowski, Adam; Bakunowicz-Lazarczyk, Alina; Gorska, Maria; Szamatowicz, Jacek; Chyczewski, Lech; Mysliwiec, Janusz

    2015-01-01

    Purpose. To evaluate the relationship between the expression of orbital tissue mRNA for FOXP3, CTLA-4/CD28/CD80/CD86, and CD40/CD40 and the severity of Graves' orbitopathy (GO). Material and Methods. Orbital tissue was obtained from 26 patients with GO, with mild (n = 6) or severe GO (n = 20), and 7 healthy controls. The expression of mRNA of FOXP3, CTLA-4/CD28/CD80/CD86, CD40/CD40L was measured by RT-PCR. TCR and CD3 were evaluated by immunohistochemistry. Results. Higher mRNA for FoxP3 (relative expression: 1.4) and CD40 (1.27) and lower expression of CTLA-4 (0.61) were found in the GO tissues versus controls. In severe GO as compared to mild GO higher mRNA expression for FoxP3 (1.35) and CD40 (1.4) and lower expression for CTLA-4 (0.78), CD28 (0.62), and CD40L (0.56) were found. A positive correlation was found between FOXP3 mRNA and CD3 infiltration (R = 0.796, P = 0.0000001). Conclusions. The enhanced FOXP3 mRNA expression in GO samples may suggest the dysfunction of FOXP3 cells in the severe GO. The diminished mRNA expression of CTLA-4 in severe GO may indicate inadequate T regulatory function. The enhanced mRNA expression of CD40 in severe GO and negative correlation to CRP mRNA may suggest their role in the active and inactive GO. PMID:25653477

  15. Disturbances of modulating molecules (FOXP3, CTLA-4/CD28/B7, and CD40/CD40L) mRNA expressions in the orbital tissue from patients with severe graves' ophthalmopathy.

    PubMed

    Pawlowski, Przemyslaw; Wawrusiewicz-Kurylonek, Natalia; Eckstein, Anja; Reszec, Joanna; Luczynski, Wlodzimierz; Johnson, Kristian; Kretowski, Adam; Bakunowicz-Lazarczyk, Alina; Gorska, Maria; Szamatowicz, Jacek; Chyczewski, Lech; Mysliwiec, Janusz

    2015-01-01

    Purpose. To evaluate the relationship between the expression of orbital tissue mRNA for FOXP3, CTLA-4/CD28/CD80/CD86, and CD40/CD40 and the severity of Graves' orbitopathy (GO). Material and Methods. Orbital tissue was obtained from 26 patients with GO, with mild (n = 6) or severe GO (n = 20), and 7 healthy controls. The expression of mRNA of FOXP3, CTLA-4/CD28/CD80/CD86, CD40/CD40L was measured by RT-PCR. TCR and CD3 were evaluated by immunohistochemistry. Results. Higher mRNA for FoxP3 (relative expression: 1.4) and CD40 (1.27) and lower expression of CTLA-4 (0.61) were found in the GO tissues versus controls. In severe GO as compared to mild GO higher mRNA expression for FoxP3 (1.35) and CD40 (1.4) and lower expression for CTLA-4 (0.78), CD28 (0.62), and CD40L (0.56) were found. A positive correlation was found between FOXP3 mRNA and CD3 infiltration (R = 0.796, P = 0.0000001). Conclusions. The enhanced FOXP3 mRNA expression in GO samples may suggest the dysfunction of FOXP3 cells in the severe GO. The diminished mRNA expression of CTLA-4 in severe GO may indicate inadequate T regulatory function. The enhanced mRNA expression of CD40 in severe GO and negative correlation to CRP mRNA may suggest their role in the active and inactive GO. PMID:25653477

  16. Management of the Nontoxic Multinodular Goiter in Latin America: Comparison with North America and Europe, an Electronic Survey

    Microsoft Academic Search

    Leandro Arthur Diehl; Valdinei Garcia; Steen J. Bonnema; Laszlo Hegedus; Claudio Cordeiro Albino

    To assess diagnostic and therapeutic approaches to nontoxic multinodular goiter and to compare them with previously reported American Thyroid Association (ATA) and European Thyroid Association (ETA) surveys, an online questionnaire was distributed to Latin American Thyroid Society (LATS) members. An index case was presented (42-yr-old woman with an enlarged, irregular, nontender, 50- to 80-g thyroid and no clinical suspicion of

  17. TerraFly GeoCloud: Online Spatial Data Analysis System Yun Lu, Mingjin Zhang, Tao Li, Chang Liu, Erik Edrosa, Naphtali Rishe

    E-print Network

    Li, Tao

    Fly TerraFly is a system for querying and visualizing of geospatial data developed by High Performance photography, satellite imagery and various overlays, such as street names, roads, restaurants, services a web browser with a bunch of advanced functionalities and features such as user-friendly geospatial

  18. RNA today. Molecular Evolution of Introns and Other RNA Elements: a Keystone Symposium, Taos, NM, USA, February 2-8, 1991.

    PubMed

    Joyce, G F

    1991-06-01

    RNA research is alive and well. The joyride for those studying the biochemistry and molecular biology of RNA continues, although perhaps not at the thrill-a-month pace of recent years. The Keystone Symposium provided an opportunity to gain deeper insight into RNA-based biological phenomena by attempting to place current research in an evolutionary context. In this sense the meeting was an unqualified success. The meeting participants, having been warmed by the New Mexico sun and the chile-laden cuisine, now return to their laboratories determined to pursue not only the details of RNA biochemistry and molecular biology, but also the evolutionary implications of their work. PMID:1716983

  19. Complete set of material constants of single domain (K, Na)(Nb, Ta)O3 single crystal and their orientation dependence

    NASA Astrophysics Data System (ADS)

    Zheng, Limei; Li, Shiyang; Sang, Shijing; Wang, Junjun; Huo, Xiaoqing; Wang, Rui; Yuan, Zhongyuan; Cao, Wenwu

    2014-11-01

    A self-consistent complete set of dielectric, piezoelectric, and elastic constants for single domain Ta modified (K, Na)NbO3 (KNN) crystal was determined. This full set constant for single domain KNN-based crystals allowed the prediction of orientation dependence of the longitudinal dielectric, piezoelectric, elastic coefficients, and electromechanical coupling factors. The maximum piezoelectric and electromechanical properties were found to exist near [001]C. In addition, material constants of [001]C poled domain engineered single crystal with 4 mm symmetry were experimentally measured and compared with the calculated values. Based on this, extrinsic contribution to the piezoelectricity was estimated to be ˜20%.

  20. Complete set of material constants of single domain (K, Na)(Nb, Ta)O3 single crystal and their orientation dependence.

    PubMed

    Zheng, Limei; Li, Shiyang; Sang, Shijing; Wang, Junjun; Huo, Xiaoqing; Wang, Rui; Yuan, Zhongyuan; Cao, Wenwu

    2014-11-24

    A self-consistent complete set of dielectric, piezoelectric, and elastic constants for single domain Ta modified (K, Na)NbO3 (KNN) crystal was determined. This full set constant for single domain KNN-based crystals allowed the prediction of orientation dependence of the longitudinal dielectric, piezoelectric, elastic coefficients, and electromechanical coupling factors. The maximum piezoelectric and electromechanical properties were found to exist near [001] C . In addition, material constants of [001] C poled domain engineered single crystal with 4?mm symmetry were experimentally measured and compared with the calculated values. Based on this, extrinsic contribution to the piezoelectricity was estimated to be ?20%. PMID:25489119

  1. Statistical thermodynamics of 1-butanol, 2-methyl-1-propanol, and butanal Prasenjit Seal, Ewa Papajak, Tao Yu, and Donald G. Truhlar

    E-print Network

    Truhlar, Donald G

    investigation is to calculate partition functions and thermodynamic quan- tities, viz., entropy, enthalpy, heat structure of HOOO J. Chem. Phys. 136, 034303 (2012) A spin-adapted size-extensive state-specific multi

  2. Course Name NMSU UNM Taos *NMSU reserves the right to modify these course equivalencies based on curriculum changes and program requirements. Updated: 4/16/14

    E-print Network

    Nishiguchi, Michele

    Algebra MATH 121G MATH 121 Trigonometry MATH 175 MATH 123 Calculus I MATH 191G MATH 162 Calculus II MATH 192G MATH 163 Math Appreciation MATH 210G MATH 129 Calculus III MATH 291 MATH 264 Principles (Issues) SOC 201G SOC 211 Marriage & Family SOC 258 SOC 225 Elementary Spanish I SPAN 111 SPAN 101

  3. LANL:CPO: Los Alamos National Laboratory Impacts and Investments in Taos County LA-UR 11-02376 (2/13/13)

    E-print Network

    , Engineering, and Mathematics (STEM) education and enrichment initiatives through Workforce Development, Student Internships, Teacher and Faculty Professional Development, and Public Understanding of Science for education, economic development, and charitable giving programs through the LANS, LLC Community Commitment

  4. Confronting terrestrial biosphere models with forest inventory data Jeremy. W. Lichstein, Ni-Zhang Golaz, Sergey Malyshev, Elena Shevliakova, Tao Zhang, Justin

    E-print Network

    Lichstein, Jeremy W.

    trees from diameter at breast height (dbh) values reported by FIA. Growth was calculated across two plot-unit-area estimates (which are then summed to yield plot-level AGB values), we multiplied by tree-level expansion). A "growth trees per acre" expansion factor was only available for trees with a current (second plot

  5. Algebraic Differential Fault Attacks on LED using a Single Fault Injection Xinjie Zhaoa,, Shize Guob, Fan Zhangc, Tao Wanga, Zhijie Shic, Keke Jia

    E-print Network

    and generic fault analysis technique which significantly improves DFA. Keywords: Algebraic cryptanalysis, Differential fault analysis, Single fault injection, CryptoMiniSat, LED. 1. Introduction 1.1. BackgroundAlgebraic Differential Fault Attacks on LED using a Single Fault Injection Xinjie Zhaoa,, Shize

  6. The tao of IGF-1: insulin-like growth factor receptor activation increases pain by enhancing T-type calcium channel activity.

    PubMed

    Stemkowski, Patrick L; Zamponi, Gerald W

    2014-10-01

    T-type calcium channels are important players in the transmission of pain signals in the primary afferent pathway. Indeed, inhibiting or depleting T-type calcium channels in dorsal root ganglion (DRG) neurons mediates analgesia. Conversely, nerve injury or peripheral inflammation have been shown to induce T-type calcium channel activity in DRG neurons, and this in turn has been linked to the development of chronic pain states. The mechanisms that underlie this enhancement of T-type channels remain incompletely understood and may include changes in channel stability in the plasma membrane or alterations in channel function. In this issue of Science Signaling, Zhang and colleagues identify a cell signaling pathway that potently regulates T-type calcium channel activity in afferent neurons and link this process to pain hypersensitivity. Specifically, they show that insulin-like growth factor-1 receptors in DRG neurons mediate a protein kinase C ? (PKC?)-dependent enhancement of T-type calcium currents and that interfering with this pathway reduces both mechanical and thermal pain hypersensitivity in rodents. Targeting this process offers a new avenue for developing pain therapeutics. PMID:25292211

  7. Directory of Endocrine and Metabolic Diseases Organizations

    MedlinePLUS

    ... Graves’ ophthalmopathy and includes section on eye care. Growth Hormone See National Hormone and Pituitary Program (NHPP): Information for People Treated with Pituitary Human Growth Hormone (Summary) Back to Top H Hashimoto's Disease ? ...

  8. Surgical treatment of proptosis bulbi by three-wall orbital decompression

    Microsoft Academic Search

    K. G. H van der Wal; J. G. A. M de Visscher; R. J Boukes; B Smeding

    1995-01-01

    Purpose: Three-wall orbital decompression was tested using a coronal approach as a technique.Patients and Methods: Three-wall orbital decompression by a coronal approach was performed in three patients with proptosis due to Grave's ophthalmopathy, in six patients with Grave's ophthalmopathy because their vision was threatened due to optic nerve compression, and in one patient with exorbitism due to Crouzon's syndrome for

  9. Annual Report: 0207819 Page 1 of 4

    E-print Network

    Mukherjee, Amar

    is a Ph. D. student working on this project. His primary reserach is concerned with text compression in this grant. Mr. Satya is working under Prof. Mukherjee's supervision. Name: Tao, Tao Worked for more than 160

  10. Taoism and Its Implications for Science Education.

    ERIC Educational Resources Information Center

    Hua, Hsiao-Peng; Chang, Chun-Yen; MacRaven, Maggie Maeve

    As one of the major schools of thought in ancient China, Taoism centers on the concept of "Tao", the Way, which has two distinct characteristics: (1) Tao itself can be deemed as a final "reality" that is equivalent to the ontology of the Universe; and (2) Tao itself cannot be defined directly by human language. Taoism posits a holistically…

  11. A near zero coefficient of thermal expansion ceramic: Tantalum oxyfluoride

    Microsoft Academic Search

    Stephanie Sawhill; Ender Savrun

    Cubic tantalum oxyfluoride (TaO2F) powders were synthesized and consolidated by hot pressing. The effects of sodium fluoride (NaF) and lithium fluoride (LiF) sintering aids on the densification and microstructure of TaO2F were investigated. Hot pressing conditions employed in this study appeared to change the stoichiometry of TaO2F, and most likely created an oxygen deficient TaO2??F. It was shown that TaO2F

  12. Adler, R. F., H.-Y. M. Yeh, N. Prasad, W.-K. Tao, and J. Simpson, 1991: Microwave simulations of a tropical rainfall system with a three-dimensional cloud model. J.

    E-print Network

    Jiang, Haiyan

    profile retrieval from a spaceborne radar. IEEE Trans., GE-31, 417­425. Anagnostou E. N., C. A. Morales, and T. Dinku, 2001: The use TRMM precipitation radar observations in determining ground radar: Radar calibration: some simple approaches. Bull. Amer. Meteor. Soc., 83, 1313-1316. ______, and C. W

  13. Treatment of antipsychotic-associated obesity with a GLP-1 receptor agonist—protocol for an investigator-initiated prospective, randomised, placebo-controlled, double-blinded intervention study: the TAO study protocol

    PubMed Central

    Ishøy, Pelle L; Knop, Filip K; Broberg, Brian V; Baandrup, Lone; Fagerlund, Birgitte; Jørgensen, Niklas R; Andersen, Ulrik B; Rostrup, Egill; Glenthøj, Birte Y; Ebdrup, Bjørn H

    2014-01-01

    Introduction Antipsychotic medication is widely associated with dysmetabolism including obesity and type 2 diabetes, cardiovascular-related diseases and early death. Obesity is considered the single most important risk factor for cardiovascular morbidity and mortality. Interventions against antipsychotic-associated obesity are limited and insufficient. Glucagon-like peptide-1 (GLP-1) receptor agonists are approved for the treatment of type 2 diabetes, but their bodyweight-lowering effects have also been recognised in patients with non-diabetes. The primary endpoint of this trial is weight loss after 3?months of treatment with a GLP-1 receptor agonist (exenatide once weekly) in patients with non-diabetic schizophrenia with antipsychotic-associated obesity. Secondary endpoints include physiological and metabolic measurements, various psychopathological and cognitive measures, and structural and functional brain MRI. Methods and analysis 40 obese patients with schizophrenia or schizoaffective disorder treated with antipsychotic drugs will be randomised to subcutaneous injection of exenatide once weekly (2?mg) or placebo for 3?months, adjunctive to their antipsychotic treatment. Ethics and dissemination The trial has been approved by the Danish Health and Medicines Authority, the National Committee on Health Research Ethics and the Danish Data Protection Agency. Trial participation presupposes theoral and written patient informed consent. An external, independent monitoring committee (Good Clinical Practice Unit at Copenhagen University Hospital) will monitor the study according to the GCP Guidelines. Trial data, including positive, negative and inconclusive results, will be presented at national and international scientific meetings and conferences. Papers will be submitted to peer-reviewed journals. Trial registration ClinicalTrials.gov identifier: NCT01794429; National Committee on Health Research Ethics project number: 36378; EudraCT nr: 2012-005404-17; The Danish Data Protection Agency project number: RHP-2012-027. PMID:24401727

  14. Questa Baseline and Pre-Mining Ground-Water Quality Investigation. 24. Seismic Refraction Tomography for Volume Analysis of Saturated Alluvium in the Straight Creek Drainage and Its Confluence With Red River, Taos County, New Mexico

    USGS Publications Warehouse

    Powers, Michael H.; Burton, Bethany L.

    2007-01-01

    As part of a research effort directed by the New Mexico Environment Department to determine pre-mining water quality of the Red River at a molybdenum mining site in northern New Mexico, we used seismic refraction tomography to create subsurface compressional-wave velocity images along six lines that crossed the Straight Creek drainage and three that crossed the valley of Red River. Field work was performed in June 2002 (lines 1-4) and September 2003 (lines 5-9). We interpreted the images to determine depths to the water table and to the top of bedrock. Depths to water and bedrock in boreholes near the lines correlate well with our interpretations based on seismic data. In general, the images suggest that the alluvium in this area has a trapezoidal cross section. Using a U.S. Geological Survey digital elevation model grid of surface elevations of this region and the interpreted elevations to water table and bedrock obtained from the seismic data, we generated new models of the shape of the buried bedrock surface and the water table through surface interpolation and extrapolation. Then, using elevation differences between the two grids, we calculated volumes of dry and wet alluvium in the two drainages. The Red River alluvium is about 51 percent saturated, whereas the much smaller volume of alluvium in the tributary Straight Creek is only about 18 percent saturated. When combined with average ground-water velocity values, the information we present can be used to determine discharge of Straight Creek into Red River relative to the total discharge of Red River moving past Straight Creek. This information will contribute to more accurate models of ground-water flow, which are needed to determine the pre-mining water quality in the Red River.

  15. A-SITE-AND/OR B-SITE-MODIFIED PBZRTIO3 MATERIALS AND (PB, SR, CA, BA, MG) (ZR, TI,NB, TA)O3 FILMS HAVING UTILITY IN FERROELECTRIC RANDOM ACCESS MEMORIES AND HIGH PERFORMANCE THIN FILM MICROACTUATORS

    NASA Technical Reports Server (NTRS)

    Roeder, Jeffrey F. (Inventor); Chen, Ing-Shin (Inventor); Bilodeau, Steven (Inventor); Baum, Thomas H. (Inventor)

    2004-01-01

    A modified PbZrTiO.sub.3 perovskite crystal material thin film, wherein the PbZrTiO.sub.3 perovskite crystal material includes crystal lattice A-sites and B-sites at least one of which is modified by the presence of a substituent selected from the group consisting of (i) A-site substituents consisting of Sr, Ca, Ba and Mg, and (ii) B-site substituents selected from the group consisting of Nb and Ta. The perovskite crystal thin film material may be formed by liquid delivery MOCVD from metalorganic precursors of the metal components of the thin film, to form PZT and PSZT, and other piezoelectric and ferroelectric thin film materials. The thin films of the invention have utility in non-volatile ferroelectric memory devices (NV-FeRAMs), and in microelectromechanical systems (MEMS) as sensor and/or actuator elements, e.g., high speed digital system actuators requiring low input power levels.

  16. Tao, M., Conway, R., Cheta, S., Chiang, H.-C., & Yan, T.-F. Tyler, J. M., Reinhardt, B. N., & Branton, D. (1980) J. Biol. (1981) Cold Spring Harbor Conf. Cell Proliferation 8,

    E-print Network

    1980-01-01

    was reversible and occurred within the time resolution (5 ms) of the quench-flow technique used receptor at the vertebrate neuromuscular junction and in the electric organ of electric fish transduces) suggested that three fundamental steps are involved in the transduction process: (1) acetylcholine binds

  17. Interaction of Ta-O and perpendicular magnetic anisotropy of Ta/Pd (0-2.4 nm)/Co2FeAl0.5Si0.5/MgO/Ta structured films

    NASA Astrophysics Data System (ADS)

    You, C. Y.; Fu, H. R.; Zhang, X.; Tian, N.; Wang, P. W.

    2015-03-01

    Perpendicular magnetic anisotropy (PMA) was realized by inserting Pd layer into the stack of Ta/Pd (0-2.4 nm)/Co2FeAl0.5Si0.5/MgO/Ta. The realization of PMA is accompanied by the (Co, Fe)-O reduction at Co2FeAl0.5Si0.5/MgO interface under annealing. Without inserting Pd layer, the annealed Ta/Co2FeAl0.5Si0.5/MgO/Ta film presents an in-plane magnetization. Through X-ray photoelectron spectrometry analyzes, it was found that the oxygen was enriched at the interface of Ta/Co2FeAl0.5Si0.5. This work clarifies that the inserted Pd layer effectively blocks the diffusion of interfacial oxygen to Ta layer, achieving the beneficial redox reaction at Co2FeAl0.5Si0.5/MgO interface to realize PMA.

  18. Silver Nanocrystals DOI: 10.1002/anie.200601277

    E-print Network

    Yang, Peidong

    Scattering Signatures** Andrea Tao, Prasert Sinsermsuksakul, and Peidong Yang* Subwavelength silver in the visible region, giving rise to the brilliant colors that are characteristic of their colloidal solutions

  19. Retrobulbar pressures measured during surgical decompression of the orbit.

    PubMed Central

    Otto, A J; Koornneef, L; Mourits, M P; Deen-van Leeuwen, L

    1996-01-01

    AIMS/BACKGROUND: In Graves' ophthalmopathy the increase in volume of intraocular muscles and fat will cause elevated intraorbital pressure. In order to investigate the pressure levels involved, intraorbital pressure, or retrobulbar pressure (RBP) was measured continuously in orbits of patients with Graves' ophthalmopathy during surgical decompression. METHODS: Retrobulbar pressure was measured before and during surgical decompression using an intraorbitally applied pressure transducer. RESULTS: In eight patients with dysthyroid optic neuropathy (DON) RBPs between 17 and 40 mm Hg were recorded. At the end of the surgical procedure the mean RBP was reduced from 28.7 mm Hg to 18.7 mm Hg, the decrease ranging from 8 to 12 mm Hg, which showed a high correlation with the starting pressures (p < 0.001). In two cases without DON, pressures were 11 and 9 mm Hg. Forces exerted by spatula manipulation usually resulted in a RBP level of more than 70 mm Hg. CONCLUSIONS: This study shows that RBPs are markedly elevated in Graves' ophthalmopathy and that surgical decompression can result in a significant reduction in the intraorbital pressure. Optic nerve dysfunction in Graves' ophthalmopathy may not be caused exclusively by the direct pressure of swollen extraocular muscles upon the optic nerve, but also by a raised RBP. It is hypothesised that the damage inflicted upon the optic nerve can be caused in consequence by RBP induced incarceration of the nerve, compressed by surrounding periosteal lined orbital fat bulging posteriorly into the entrance of the optic canal. PMID:9059266

  20. Effect of Tumor Necrosis Factor-a, Interferon-g, and Transforming Growth Factor-b on Adipogenesis and Expression of Thyrotropin Receptor in Human Orbital Preadipocyte Fibroblasts

    Microsoft Academic Search

    ROSANEE W. VALYASEVI; SOMA C. JYONOUCHI; CHARYL M. DUTTON; NATEE MUNSAKUL; REBECCA S. BAHN

    Graves' ophthalmopathy (GO) is an orbital autoimmune disease that is closely associated with Graves' hyperthyroidism. Examination of retroorbital tissues in GO reveals an accumulation of glycosami- noglycans, increased fat volume, lymphocytic infiltration, and the presence of several inflammatory cytokines. A subpopulation of hu- man orbital fibroblasts can be differentiated in vitro into cells with the morphologic features of adipocytes. We

  1. Radiation retinopathy

    SciTech Connect

    Parker, R.G.; Withers, H.R.

    1988-01-01

    A letter to the editor discusses the effectiveness and risk of radiation treatment of Grave's ophthalmopathy. The authors are unable to document a single instance in which retinopathy can be attributed to therapy with a total dose of 2000 cGy when delivered in daily increments of 180 to 200 cGy.

  2. Smoking and thyroid disorders--a meta-analysis

    Microsoft Academic Search

    Peter Vestergaard

    2002-01-01

    Background: Smoking has been associated with Graves' disease, but it remains unclear if the association is present in other thyroid disorders. Outcome variables: Graves' disease, Graves' ophthalmopathy, toxic nodular goitre, non-toxic goitre, post-partum thyroid disease, Hashimoto's thyroiditis, or hypothyroidism. Material and methods: A search of MEDLINE identified 25 studies on the association between smoking and thyroid diseases. Results: In Graves'

  3. Lhermitte-Duclos disease.

    PubMed

    Chiofalo, Maria Grazia; Cappabianca, Paolo; Del Basso De Caro, Maria Laura; Pezzullo, Luciano

    2007-04-01

    A 46-year-old female patient with previously recognized Graves' ophthalmopathy, underwent total thyroidectomy. After thyroid surgery exophthalmos worsened and signs unsteadiness of gait appeared. Magnetic resonance imaging showed a lesion in the basal portion of the left cerebellar hemisphere. Therefore, the patient underwent surgery. Pathological examination revealed dysplastic gangliocytoma of the cerebellum (Lhermitte-Duclos disease). PMID:17021955

  4. Accepted Manuscript Mathematical Modeling of Vertebrate Limb Development

    E-print Network

    Zhang, Yong-Tao

    Accepted Manuscript Review Mathematical Modeling of Vertebrate Limb Development Yong-Tao Zhang.A. Newman, Mathematical Modeling of Vertebrate Limb Development, Mathematical Biosciences (2012), doi: http Modeling of Vertebrate Limb Development Yong-Tao Zhang1, *, Mark S. Alber1,2, *, Stuart A. Newman3, * 1

  5. Turning Patrons into Partners When Choosing an Integrated Library System

    ERIC Educational Resources Information Center

    Ryan, Terry

    2004-01-01

    UCLA, which has one of the top 10 research libraries in the country, has been using Taos software since 1996. However in 2001, Sirsi Corp. announced that it was freezing development on Taos software. As the associate university librarian for information technology at UCLA, the author relates that it was his responsibility to lead the way through…

  6. Compressed Pattern Matching for Predictive Lossless Image Encoding School of EECS

    E-print Network

    Mukherjee, Amar

    work, we studied the most three popular lossless image compression schemes: lossless JPEG, CALICCompressed Pattern Matching for Predictive Lossless Image Encoding Tao Tao School of EECS topic in computer science. Most works have been done in CPM are for text or for lossy compressed image

  7. Noname manuscript No. (will be inserted by the editor)

    E-print Network

    Adler, Andy

    Noname manuscript No. (will be inserted by the editor) Tao Dai · Manuchehr Soleimani · Andy Adler frames independently, although data are actually highly correlated espe- cially in high speed EIT systems reconstruction is posed in terms of an augmented image and Tao Dai System and Computer Engineering, Carleton

  8. Maximum Likelihood Estimation of the Random-Clumped Multinomial Model as Prototype

    E-print Network

    Gobbert, Matthias K.

    demonstrated the effectiveness of LMVM in the setting of natural language processing. Using TAO to con- duct distribution. We compute MLEs for this model in parallel using the Toolkit for Advanced Optimization (TAO- connect. We demonstrate that for larger problems, scaling the number of processes improves wall clock time

  9. MICROCOSM AUTONOMOUS NAVIGATION SYSTEM ON-ORBIT OPERATION

    Microsoft Academic Search

    Robert W. Hosken; James R. Wertz

    This paper describes the operation of the Microcosm Autonomous Navigation System (MANS) which was launched as an Air Force Phillips Laboratory Technology for Autonomous Operational Survivability -(TAOS) experimental payload on March 13, 1994. MANS determines the position, velocity, attitude, attitude rate, ground look point, and lighting conditions of the host satellite. As implemented on TAOS, MANS uses two opposite facing

  10. LOS ALAMOS NATIONAL LABORATORY REGIONAL PURCHASING PROGRAM

    E-print Network

    , Pojoaque, San Ildefonso San Juan, Santa Clara, Taos, and Tesuque) in the future. The LANS Regional and is committed to benefiting the Northern New Mexico Community (which includes Taos Santa Fe, Rio Arriba be able to demonstrate, if and when requested, through the submission of New Mexico gross receipts tax

  11. Automated Design of Digital Microfluidic Lab-on-Chip under Pin-Count Constraints

    E-print Network

    Chakrabarty, Krishnendu

    Automated Design of Digital Microfluidic Lab-on-Chip under Pin-Count Constraints Tao Xu, USA. E-mail: {tao,krish}@ee.duke.edu ABSTRACT Digital microfluidic biochips, as referred to as lab-referencing, Lab-on-Chip, Microfluidics, Pin-count constraints 1. INTRODUCTION Microfluidics technology has made

  12. Managing Biological Information Using Biological Knowledge Carole A. Goble and Robert D. Stevens

    E-print Network

    Stevens, Robert

    Managing Biological Information Using Biological Knowledge Carole A. Goble and Robert D. Stevens bioinformatics resources. The knowl- edge in the TAMBIS ontology (TaO) allows biologists to form complex, multi within the source and how to transfer information between resources. The TaO can be seen to add

  13. An assessment of buoy-derived and numerical weather prediction surface heat fluxes in the tropical Pacific

    Microsoft Academic Search

    Meghan F. Cronin; Christopher W. Fairall; Michael J. McPhaden

    2006-01-01

    As part of the Eastern Pacific Investigation of Climate Processes program, from 2000 through 2003, the easternmost 95°W Tropical Atmosphere Ocean (TAO) moorings were enhanced to provide time series of net surface heat flux, and the National Oceanic and Atmospheric Administration ship maintaining the 95°W and 110°W TAO lines was enhanced to monitor surface heat fluxes and atmospheric boundary layer

  14. Investigation of the expression of mediators of neovascularization from mononuclear leukocytes in thromboangiitis obliterans.

    PubMed

    Fazeli, Bahare; Rafatpanah, Houshang; Ravari, Hassan; Hosseini, Reza Farid; Rezaee, S A Rahim

    2014-06-01

    The aim of this study was to investigate the expression of the cytokines, chemokines and effective molecules of peripheral blood mononuclear cells (PBMCs) that play a role in neovascularization in thromboangiitis obliterans (TAO). Lymphocytes from TAO patients (n = 20) and control subjects (healthy smokers [n = 16] and non-smokers [n = 17]) were evaluated using realtime polymerase chain reaction in order to examine the mRNA expression of CXCL1 and interleukin 8 (IL-8; inducers of collateral development by recruitment of circulating progenitor cells [CPCs]), endothelial cell growth factor A (VEGF-A) and inducible nitric oxide synthase (iNOS; inducers of angiogenesis) and interferon gamma (IFN-?) and vascular endothelial growth factor receptor 1 (VEGFR-1; inhibitors of angiogenesis). CXCL1 expression was significantly higher in the TAO patients than control subjects. The expressions of IL-8, VEGFR-1 and IFN-? were significantly higher in the TAO patients and smokers than in non-smokers. However, no differences in iNOS and VEGF-A expression were noted. In conclusion, PBMCs from TAO patients expressed cytokines that potentially recruit CPCs and promote arteriogenesis. However, TAO patients typically have low CPC levels, perhaps due to high oxidative stress. Further studies are recommended in order to investigate the efficacy of antioxidant therapy on the outcome of TAO before administration of angiogenic factors. PMID:23567329

  15. Damping of thermoacoustic oscillations

    NASA Technical Reports Server (NTRS)

    Tward, E.; Mason, P. V.

    1982-01-01

    A commonly encountered and troublesome problem in cryogenic systems is related to the occurrence of thermoacoustic oscillations (TAO). The oscillations are accompanied by large heat fluxes which can cause large increases in the boiloff from dewars. Such a boiloff can lead to a serious degradation in performance. It appears, therefore, highly advisable to incorporate mechanisms for damping TAO in those parts of the system where there oscillations might occur. The present investigation is concerned with the criteria for the design of such damping mechanisms. Attention is given to the theory regrading the suppression of TAO, a damper consisting of a capillary with a surge tank, and porous solid dampers.

  16. Obstruction of the superior mesenteric artery due to emboli from the thoracic aorta in a patient with thromboangiitis obliterans.

    PubMed

    Kamiya, Chiaki; Deguchi, Juno; Kitaoka, Tadashi; Suzuki, Jun; Abe, Keiko; Sato, Osamu

    2014-01-01

    A 48-year-old woman presented at our hospital with acute abdominal pain 3 years after being diagnosed with thromboangiitis obliterans (TAO). Computed tomography revealed occlusion of the superior mesenteric artery (SMA) and multiple kidney infarction with thrombus floating in the thoracic aorta connected with the intercostal artery. Despite emergency embolectomy, further thromboembolism eventually required massive resection of the intestine with jejunostomy and colostomy and permanent intravenous hyper-alimentation therapy. Although TAO rarely involves the large artery, the aorta could be the source of embolization in patients with TAO. PMID:25298837

  17. Comment on "Criteria for Separability of Multipartite Quantum System"

    NASA Astrophysics Data System (ADS)

    Chang, Da-Wei

    2015-07-01

    Recently, Tao et al. (Int. J. Theor. Phys. 52 (6), 1970-1978, 2013) established a representation of density matrix for multipartite quantum system. Moreover, according to this representation of the density matrix for multipartite quantum system, Tao et al. (Int. J. Theor. Phys. 52 (6), 1970-1978, 2013) have presented two necessary criteria for separability of multipartite quantum system of arbitrary dimensions, for example, see Theorem 2.1 and Theorem 2.2. In this Comment, we would like to point out that Theorem 2.2 given by Tao et al. (Int. J. Theor. Phys. 52 (6), 1970-1978, 2013) is incorrect in general.

  18. [Method for assessing involution ophthalmoendotoxicosis by fluorescent analysis of lacrimal fluid].

    PubMed

    Kurysheva, N I; Deev, A I; Gryzunov, Iu A; Komarova, M N

    2000-01-01

    A method for evaluating the binding capacity of aqueous humor albumin as endoophthalmotoxicosis indicator is proposed, consisting in evaluation of this parameter in the lacrimal fluid by fluorescent probe K-35. A correlation between the studied parameter in aqueous humor, lacrimal fluid, and blood serum has been detected. Albumin binding capacity in the above biological fluids of patients with involution ophthalmopathy was low. PMID:10918844

  19. High-resolution CT of lesions of the optic nerve

    SciTech Connect

    Peyster, R.G.; Hoover, E.D.; Hershey, B.L.; Haskin, M.E.

    1983-05-01

    The optic nerves are well demonstrated by high-resolution computed tomography. Involvement of the optic nerve by optic gliomas and optic nerve sheath meningiomas is well known. However, nonneoplastic processes such as increased intracranial pressure, optic neuritis, Grave ophthalmopathy, and orbital pseudotumor may also alter the appearance of the optic nerve/sheath on computed tomography. Certain clinical and computed tomographic features permit distinction of these nonneoplastic tumefactions from tumors.

  20. Lhermitte-Duclos disease

    Microsoft Academic Search

    Maria Grazia Chiofalo; Paolo Cappabianca; Maria Laura Del Basso De Caro; Luciano Pezzullo

    2007-01-01

    A 46-year-old female patient with previously recognized Graves’ ophthalmopathy, underwent total thyroidectomy. After thyroid\\u000a surgery exophthalmos worsened and signs unsteadiness of gait appeared. Magnetic resonance imaging showed a lesion in the basal\\u000a portion of the left cerebellar hemisphere. Therefore, the patient underwent surgery. Pathological examination revealed dysplastic\\u000a gangliocytoma of the cerebellum (Lhermitte-Duclos disease).

  1. Treatment modalities of thyroid related orbitopathy

    PubMed Central

    Ahn, Eric S; Subramanian, Prem S

    2014-01-01

    Aims: The aim was to highlight recent advances in the treatment of thyroid eye disease. Settings and Design: Review article. Materials and Methods: Existing literature and the authors’ experience was reviewed. Results: Thyroid ophthalmopathy is a disfiguring and vision-threatening complication of autoimmune thyroid disease that may develop or persist even in the setting of well-controlled systemic thyroid status. Treatment response can be difficult to predict, and optimized algorithms for disease management do not exist. Thyroid ophthalmopathy should be graded for both severity and disease activity before choosing a treatment modality for each patient. The severity of the disease may not correlate directly with the activity; medical treatment is most effective in active disease, and surgery is usually reserved for quiescent disease with persistent proptosis and/or eyelid changes. Conclusions: Intravenous pulsed corticosteroids, orbital radiotherapy, and orbital surgical techniques form the mainstay of current management of thyroid ophthalmopathy. Immunosuppressive and biologic agents may have a role in treating active disease although additional safety and efficacy studies are needed. PMID:25449934

  2. Distributed Basis Pursuit

    E-print Network

    2012-03-14

    sensor network, and is designed to minimize the communication between nodes. ... In particular, in the recent field of compressed sensing, BP plays a key ...... [12] E. Candès and T. Tao, “Near-optimal signal recovery from random projections: ...

  3. Synthesis and characterization of single-crystal indium nitride nanowires

    E-print Network

    Zhou, Chongwu

    Synthesis and characterization of single-crystal indium nitride nanowires Tao Tang, Song Han, Wu semiconducting III-V nitrides have long been viewed as promising materials for electronic and optoelectronic

  4. Geochemical associations and availability of cadmium (Cd) in a paddy field system, Northwestern Thailand 

    E-print Network

    Kosolsaksakul, Peerapat

    2014-11-27

    The Mae Tao watershed, northwestern Thailand, has become contaminated with cadmium (Cd) from the zinc mining activities area in the nearby Thanon-Thongchai mountains. Consumption of Cd-contaminated rice has led to ...

  5. Plunnecke and Kneser type theorems for dimension estimates Cedric Lecouvey

    E-print Network

    Paris-Sud XI, Université de

    on this subject due to Diderrich [2], Hamidoune [6], Kemperman [11], Olson [15], Ruzsa [17], Tao [20] and many]. Nevertheless, there exist in this case weaker versions due to Diderrich [2] and Olson [15]. 1 hal-00618241

  6. 77 FR 33240 - Certain Semiconductor Chips With DRAM Circuitry, and Modules and Products Containing Same...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-05

    ...Certain Semiconductor Chips With DRAM Circuitry, and Modules and Products Containing Same Determination Not To Review an Initial Determination...States patents. The Commission issued a notice of investigation naming Nanya Technology Corporation of TaoYuan, Taiwan and...

  7. JOURNAL OF LIGHTWAVE TECHNOLOGY, VOL. 27, NO. 24, DECEMBER 15, 2009 5783 Experimental Comparison of Adaptive Optics

    E-print Network

    Kahn, Joseph M.

    of Adaptive Optics Algorithms in 10-Gb/s Multimode Fiber Systems Rahul Alex Panicker, Alan Pak Tao Lau-mode-to-multimode patchcord is shown to fail under these conditions. Index Terms--Adaptive optics, algorithms, optical fiber

  8. Security Lab Series Introduction to Web Technologies

    E-print Network

    Tao, Lixin

    Security Lab Series Introduction to Web Technologies Prof. Lixin Tao Pace University http...........................................................................................................................................1 1.1 Web ArchitectureScript..................................................................................16 4.6 Creating Your First JavaServer Page Web Application

  9. nature physics | VOL 1 | OCTOBER 2005 | www.nature.com/naturephysics COVER STORY

    E-print Network

    Loss, Daniel

    of practical devices such as ultraprecise gyroscopes. The prospects are improved by the use of atom chips-size polymer tracer particles, Tao Zhang and Steven Van Sciver have mapped out what happens when flowing He

  10. Major/Conce ntration Advisor Grad

    E-print Network

    Wang, Tao Yu, and Shiyu Zhou Versatile Networkable Robot Embedded E lectrical and Computer Systems Dr Fic1-Deficient Mouse as a Model of Cholestatic Disease MBRS-RISE Grant: R25-GM59298 Cell & Molecular

  11. 78 FR 42976 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-International...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-18

    ...SC; Fraunhofer IZM, Berlin, GERMANY; Samsung Electro- Mechanics Co., LTD, Gyeonggi-Do, REPUBLIC OF KOREA; AT&S, Leoben...this venture. Also, Foxconn, Taipei Hsien, TAIWAN; and Quanta Computer, Tao Yuan Shine, TAIWAN, have withdrawn as...

  12. Development of Revised Energy Standards for Texas Buildings: Preliminary Results 

    E-print Network

    Hunn, B. D.; Jones, J. W.; Silver, S. C.

    1988-01-01

    , and Vol. 2: -Tgchnical Report, (August 1987) Battelle Pacific Northwest Laboratory report PLN-6854. 6. Tao, Williaa F., "CSP Cooling System Performance," Heating, Pipi_ng,--d Air Condition- _i_ng, Penton Publishing Company, Cleveland, Ohio, May 1984. ...

  13. Facile Surface Functionalization of Hydrophobic Magnetic Nanoparticles

    E-print Network

    Tan, Weihong

    Facile Surface Functionalization of Hydrophobic Magnetic Nanoparticles Yuan Liu,,§ Tao Chen hydrophobic magnetic nanoparticles (MNPs) to an aqueous phase using tetrahydrofuran, NaOH and 3 to other types of hydrophobic nanoparticles to facilitate biomedical appli- cations of nanomaterials

  14. Long arithmetic progressions of primes

    Microsoft Academic Search

    Ben Green

    2005-01-01

    This is an article for a general mathematical audience on the author's work, joint with Terence Tao, establishing that there are arbitrarily long arithmetic progressions of primes. It is based on several one hour lectures, chiefly given at British universities.

  15. 75 FR 2889 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-International...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-19

    ...Pacific Insulating Material Co., Ltd., Shenzhen, PEOPLE'S REPUBLIC OF CHINA; Lenovo, Quarry Bay, HONG KONG- CHINA; and Quanta Computer Inc., Tao Yuan Shien, TAIWAN, have been added as parties to this venture. Also, Agile Software...

  16. El Nino Zoom to Cross-section of Temperature and Height Anomalies: August 1997 through August 1998

    NSDL National Science Digital Library

    Greg Shirah

    1998-08-01

    An animation of sea surface temperature anomaly, sea surface height anomaly, and sea temperature anomaly at depth in the Pacific Ocean from August 1997 through August 1998 as measured by NOAA AVHRR, TOPEX Poseidon, and the TAO TRITON Array

  17. El Nino Zoom to Cross-section of Temperature and Height Anomalies: July 1997 through August 1998

    NSDL National Science Digital Library

    Greg Shirah

    1998-08-20

    An animation of sea surface temperature anomaly, sea surface height anomaly, and sea temperature anomaly at depth in the Pacific Ocean from July 1997 through August 1998 as measured by NOAA AVHRR, TOPEX Poseidon, and the TAO TRITON Array

  18. El Nino-La Nina Zoom to Cross-section of Temperature and Height Anomalies: Jan. 1997 through Nov. 1998

    NSDL National Science Digital Library

    Greg Shirah

    1998-11-23

    An animation of sea surface temperature anomaly, sea surface height anomaly, and sea temperature anomaly at depth in the Pacific Ocean from January 1997 through November 1998 as measured by NOAA AVHRR, TOPEX Poseidon, and the TAO TRITON Array

  19. El Nino-La Nina Cross-section of Temperature and Height Anomalies: Jan. 1997 through Nov. 1998

    NSDL National Science Digital Library

    Greg Shirah

    1998-11-23

    An animation of sea surface temperature anomaly, sea surface height anomaly, and sea temperature anomaly at depth in the Pacific Ocean from July 1997 through November 1998 as measured by NOAA AVHRR, TOPEX Poseidon, and the TAO TRITON Array

  20. El Nino Zoom to Cross-section of Temperature and Height Anomalies: June 1997 through June 1998

    NSDL National Science Digital Library

    Greg Shirah

    1998-06-11

    An animation of sea surface temperature anomaly, sea surface height anomaly, and sea temperature anomaly at depth in the Pacific Ocean from June 1997 through June 1998 as measured by NOAA AVHRR, TOPEX Poseidon, and the TAO TRITON Array

  1. El Nino Zoom to Cross-section of Temperature and Height Anomalies: September 1997 through July 1998

    NSDL National Science Digital Library

    Greg Shirah

    1998-07-01

    An animation of sea surface temperature anomaly, sea surface height anomaly, and sea temperature anomaly at depth in the Pacific Ocean from September 1997 through July 1998 as measured by NOAA AVHRR, TOPEX Poseidon, and the TAO TRITON Array

  2. El Nino-La Nina Cross-section of Temperature and Height Anomalies: Jan. 1997 through Febr. 1999

    NSDL National Science Digital Library

    Greg Shirah

    1999-04-01

    An animation of sea surface temperature anomaly, sea surface height anomaly, and sea temperature anomaly at depth in the Pacific Ocean from January 1997 through February 1999 as measured by NOAA AVHRR, TOPEX Poseidon, and the TAO TRITON Array

  3. El Nino Zoom to Cross-section of Temperature and Height Anomalies: July 1997 through October 1998

    NSDL National Science Digital Library

    Greg Shirah

    1998-10-26

    An animation of sea surface temperature anomaly, sea surface height anomaly, and sea temperature anomaly at depth in the Pacific Ocean from July 1997 through October 1998 as measured by NOAA AVHRR, TOPEX Poseidon, and the TAO TRITON Array

  4. El Nino-La Nina Cross-section of Temperature and Height Anomalies: Jan. 1997 through Dec. 1999

    NSDL National Science Digital Library

    Greg Shirah

    1999-12-21

    An animation of sea surface temperature anomaly, sea surface height anomaly, and sea temperature anomaly at depth in the Pacific Ocean from January 1997 through December 1999 as measured by NOAA AVHRR, TOPEX Poseidon, and the TAO TRITON Array

  5. Comparison and Sensitivity of ODASI Ocean Analyses in the Tropical Pacific CHAOJIAO SUN

    E-print Network

    Wittenberg, Andrew

    Comparison and Sensitivity of ODASI Ocean Analyses in the Tropical Pacific CHAOJIAO SUN Global Goddard Space Flight Center, Greenbelt, and Science Applications International Corporation, Beltsville. Global expendable bathythermograph and Tropical Atmosphere Ocean (TAO) temperature profile observations

  6. BLOOD CHARACTERIZATION FROM PULSATILE BIOIMPEDANCE SPECTROSCOPY

    E-print Network

    Adler, Andy

    BLOOD CHARACTERIZATION FROM PULSATILE BIOIMPEDANCE SPECTROSCOPY Tao Dai Systems and Computer of blood using three measuring frequencies. Characterization of blood bioimpedance properties; however, Current bioimpedance spectroscopy measurements of blood are ei- ther in vitro[6

  7. JOHN-NIRENERG INEQUALITY AND ATOMIC DECOMPOSITION FOR NONCOMMUTATIVE

    E-print Network

    Mei, Tao

    . JOHN-NIRENERG INEQUALITY AND ATOMIC DECOMPOSITION FOR NONCOMMUTATIVE MARTINGALES GUIXIANG HONG AND TAO MEI Abstract. In this paper, we study the John-Nirenberg inequality for BMO and the atomic. row) John-Nirenberg inequality for all 0

  8. 78 FR 5496 - Certain Paper Shredders, Certain Processes for Manufacturing or Relating to Same and Certain...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-25

    ...Province, China, 518026; Elite Business Machines Ltd., Unit 1A, 2nd Floor, Fu Tao Building, 98 Argyle Street, Mong Kok, Kowloon, Hong Kong Special Administrative Region, China; New United Office Equipment USA, Inc., 3701 Commercial Avenue,...

  9. 77 FR 50542 - Culturally Significant Objects Imported for Exhibition Determinations: “New Photography 2012...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-21

    ...Objects Imported for Exhibition Determinations: ``New Photography 2012: Michele Abeles, Birdhead (Ji Weiyu and Song Tao...that the objects to be included in the exhibition ``New Photography 2012: Michele Abeles, Birdhead (Ji Weiyu and Song...

  10. Beach Sand, Not Water, More Likely to Make You Sick

    MedlinePLUS

    ... led by Tao Yan of the University of Hawaii at Manoa. Public health experts have long known ... To find out why that's the case, the Hawaii scientists created laboratory simulations of beaches and seawater ...

  11. Sea Surface Temperature Anomalies show La Nina, El Nino and Normal Conditions in the Pacific Ocean

    NSDL National Science Digital Library

    Tropical Atmosphere Ocean project

    These TAO project graphics compare sea surface temperature between normal conditions in 1993, El Nino in 1997, and La Nina in 1998. Additional images and background information can also be accessed from this page.

  12. AUTOMATED, ACCURATE, AND INEXPENSIVE SOLUTION-PREPARATION ON A DIGITAL MICROFLUIDIC BIOCHIP*

    E-print Network

    Chakrabarty, Krishnendu

    AUTOMATED, ACCURATE, AND INEXPENSIVE SOLUTION- PREPARATION ON A DIGITAL MICROFLUIDIC BIOCHIP* Tao propose an electrowetting-based "digital" microfluidic biochip design for automated solution-crystallization application. Index Terms: Digital microfluidics, droplets, laboratory automation, sample preparation. I

  13. Thromboangiitis obliterans with cryoglobulinemia.

    PubMed

    Owlia, Mohammad Bagher; Mehrpoor, Golbarg

    2014-11-01

    Thromboangiitis obliterans (TAO), or Buerger's disease, is a vascular occlusive disease associated with cigarette smoking. It typically affects medium sized vessels of extremities. Basic pathology of TAO is described to be endothelial activation with highly inflammatory intraluminal thrombosis preserving internal elastic membrane. Cryoglobulins are immunoglobulins that precipitate in the cold and dissolve on re-warming. Cryoglobulinemic vasculitis is a typical small vessel disease associated with cryoglobulinemia commonly bearing typical purpuric skin lesions. An association of TAO with cryoglobulinemia is not reported yet. We report a 34-year-old male heavy cigarette smoker seen for extremity pain and cyanosis of left little finger along with skin rashes characteristic of small vessel disease. Initial presentation of his symptoms at winter and unusual purpuric skin lesions led to search for cold-agglutinating globulins in his plasma. He had severe cryoglobulinemia while the other laboratory tests were normal. TAO associated with cryoglobulinemia merges as a possibility. PMID:25404449

  14. A-site- and/or B-site-modified PbZrTiO3 materials and (Pb, Sr, Ca, Ba, Mg) (Zr, Ti, Nb, Ta)O3 films having utility in ferroelectric random access memories and high performance thin film microactuators

    NASA Technical Reports Server (NTRS)

    Roeder, Jeffrey F. (Inventor); Chen, Ing-Shin (Inventor); Bilodeau, Steven (Inventor); Baum, Thomas H. (Inventor)

    2001-01-01

    A modified PbZrTiO.sub.3 perovskite crystal material thin film, wherein the PbZrTiO.sub.3 perovskite crystal material includes crystal lattice A-sites and B-sites at least one of which is modified by the presence of a substituent selected from the group consisting of (i) A-site substituents consisting of Sr, Ca, Ba and Mg, and (ii) B-site substituents selected from the group consisting of Nb and Ta. The perovskite crystal thin film material may be formed by liquid delivery MOCVD from metalorganic precursors of the metal components of the thin film, to form PZT and PSZT, and other piezoelectric and ferroelectric thin film materials. The thin films of the invention have utility in non-volatile ferroelectric memory devices (NV-FeRAMs), and in microelectromechanical systems (MEMS) as sensor and/or actuator elements, e.g., high speed digital system actuators requiring low input power levels.

  15. Materials, Devices, and Circuits of Transparent Amorphous-Oxide Semiconductor

    Microsoft Academic Search

    Hideya Kumomi; Seiichiro Yaginuma; Hideyuki Omura; Amita Goyal; Ayumu Sato; Masaya Watanabe; Mikio Shimada; Nobuyuki Kaji; Kenji Takahashi; Masato Ofuji; Tomohiro Watanabe; Naho Itagaki; Hisae Shimizu; Katsumi Abe; Yoshinori Tateishi; Hisato Yabuta; Tatsuya Iwasaki; Ryo Hayashi; Toshiaki Aiba; Masafumi Sano

    2009-01-01

    This paper presents the following recent investigations of transparent amorphous-oxide semiconductors (TAOS) from materials to devices and circuits. 1) Composition of metals in TAOS are widely explored with the aim of seeking semiconductors suitable for the channel layers of thin-film transistors (TFTs) composing backplanes for flat-panel displays. It is found in combinatorial approaches to the materials exploration that indium-based ternary

  16. Optical, electrical and mechanical properties of the tantalum oxynitride thin films deposited by pulsing reactive gas sputtering

    Microsoft Academic Search

    H. Le Dréo; O. Banakh; H. Keppner; P.-A. Steinmann; D. Briand; N. F. de Rooij

    2006-01-01

    Thin films of tantalum oxynitride were prepared by reactive magnetron sputtering using a Ta target and N2 and O2 as reactive gases. The nitrogen flow was kept constant while the oxygen flow was pulsed periodically. The film composition evolves progressively from TaO0.25N1.51 to TaO2.42N0.25 while increasing the oxygen pulse duty cycle without any abrupt change in the elemental content. The

  17. A Conceptual Authorization Model for Web Services1

    Microsoft Academic Search

    Paul J. Leach; Chris Kaler; Blair Dillaway; Praerit Garg; Brian LaMacchia; Butler Lampson; John Manferdelli; Rick Rashid; John Shewchuk; Dan Simon; Richard Ward

    2004-01-01

    This paper describes a conceptual authorization model for Web Services. It is an adaptation of those of Taos (Lamp92) and SDSI (Lamp96) with terms changed to correspond more closely to those introduced with the WS-Security model (WS02). In contrast to the more formal and mathematical presentation used for Taos and SDSI, this presentation is conceptual and informal, which hope- fully

  18. In situ biodegradation of naphthenic acids in oil sands tailings pond water using indigenous algae-bacteria consortium.

    PubMed

    Mahdavi, Hamed; Prasad, Vinay; Liu, Yang; Ulrich, Ania C

    2015-07-01

    In this study, the biodegradation of total acid-extractable organics (TAOs), commonly called naphthenic acids (NAs), was investigated. An indigenous microbial culture containing algae and bacteria was taken from the surface of a tailings pond and incubated over the course of 120days. The influence of light, oxygen and the presence of indigenous algae and bacteria, and a diatom (Navicula pelliculosa) on the TAO removal rate were elucidated. The highest biodegradation rate was observed with bacteria growth only (without light exposure) with a half-life (t(1/2)) of 203days. The algae-bacteria consortium enhanced the detoxification process, however, bacterial biomass played the main role in toxicity reduction. Principal component analysis (PCA) conducted on FT-IR spectra, identified functional groups and bonds (representing potential markers for biotransformation of TAOs) as follows: hydroxyl, carboxyl and amide groups along with CH, arylH, arylOH and NH bonds. PMID:25841188

  19. Experimental and analytical study of thermal acoustic oscillations. [in the transfer and storage of cryogens

    NASA Technical Reports Server (NTRS)

    Spradley, L. W.; Dean, W. G.; Karu, Z. S.

    1976-01-01

    The thermal acoustic oscillations (TAO) data base was expanded by running a large number of tubes over a wide range of parameters known to affect the TAO phenomenon. These parameters include tube length, wall thickness, diameter, material, insertion length and length-to-diameter ratio. Emphasis was placed on getting good boiloff data. A large quantity of data was obtained, reduced, correlated and analyzed and is presented. Also presented are comparisons with previous types of correlations. These comparisons show that the boiloff data did not correlate with intensity. The data did correlate in the form used by Rott, that is boiloff versus TAO pressure squared times frequency to the one-half power. However, this latter correlation required a different set of correlation constants, slope and intercept, for each tube tested.

  20. Origin of the reduced attracting force between a rotating dielectric particle and a stationary one

    NASA Astrophysics Data System (ADS)

    Tian, W. J.; Liu, M. K.; Huang, J. P.

    2007-02-01

    Recently Tao and Lan [Phys. Rev. E. 72, 041508 (2005)] experimentally reported that the rotation of a dielectric particle can reduce significantly the attracting interparticle force between the rotating dielectric particle and a stationary one in argon gas. We develop the Gu-Yu-Hui theory of relaxation [J. Chem. Phys. 116, 24 (2002)] to account for the Tao-Lan observations. Excellent agreement between the theoretical results and the Tao-Lan experimental data shows that the reduction in the attracting interparticle force is due to the effect of charge relaxation. We also show that the relaxation time of touching rotating particles can be accurately determined with the aid of the developed theory, for which, however, the well-known Maxwell-Wagner relaxation time is no longer valid.

  1. Production of natural fragrance aromatic acids by coexpression of trans-anethole oxygenase and p-anisaldehyde dehydrogenase genes of Pseudomonas putida JYR-1 in Escherichia coli.

    PubMed

    Han, Dongfei; Kurusarttra, Somwang; Ryu, Ji-Young; Kanaly, Robert A; Hur, Hor-Gil

    2012-12-01

    A gene encoding p-anisaldehyde dehydrogenase (PAADH), which catalyzes the oxidation of p-anisaldehyde to p-anisic acid, was identified to be clustered with the trans-anethole oxygenase (tao) gene in Pseudomonas putida JYR-1. Heterologously expressed PAADH in Escherichia coli catalyzed the oxidation of vanillin, veratraldehyde, and piperonal to the corresponding aromatic acids vanillic acid, veratric acid, and piperonylic acid, respectively. Coexpression of trans-anethole oxygenase (TAO) and PAADH in E. coli also resulted in the successful transformation of trans-anethole, isoeugenol, O-methyl isoeugenol, and isosafrole to p-anisic acid, vanillic acid, veratric acid, and piperonylic acid, respectively, which are compounds found in plants as secondary metabolites. Because of the relaxed substrate specificity and high transformation rates by coexpressed TAO and PAADH in E. coli , the engineered strain has potential to be applied in the fragrance industry. PMID:23140548

  2. Isolation of a Gene Responsible for the Oxidation of trans-Anethole to para-Anisaldehyde by Pseudomonas putida JYR-1 and Its Expression in Escherichia coli

    PubMed Central

    Han, Dongfei; Ryu, Ji-Young; Kanaly, Robert A.

    2012-01-01

    A plasmid, pTA163, in Escherichia coli contained an approximately 34-kb gene fragment from Pseudomonas putida JYR-1 that included the genes responsible for the metabolism of trans-anethole to protocatechuic acid. Three Tn5-disrupted open reading frame 10 (ORF 10) mutants of plasmid pTA163 lost their abilities to catalyze trans-anethole. Heterologously expressed ORF 10 (1,047 nucleotides [nt]) under a T7 promoter in E. coli catalyzed oxidative cleavage of a propenyl group of trans-anethole to an aldehyde group, resulting in the production of para-anisaldehyde, and this gene was designated tao (trans-anethole oxygenase). The deduced amino acid sequence of TAO had the highest identity (34%) to a hypothetical protein of Agrobacterium vitis S4 and likely contained a flavin-binding site. Preferred incorporation of an oxygen molecule from water into p-anisaldehyde using 18O-labeling experiments indicated stereo preference of TAO for hydrolysis of the epoxide group. Interestingly, unlike the narrow substrate range of isoeugenol monooxygenase from Pseudomonas putida IE27 and Pseudomonas nitroreducens Jin1, TAO from P. putida JYR-1 catalyzed isoeugenol, O-methyl isoeugenol, and isosafrole, all of which contain the 2-propenyl functional group on the aromatic ring structure. Addition of NAD(P)H to the ultrafiltered cell extracts of E. coli (pTA163) increased the activity of TAO. Due to the relaxed substrate range of TAO, it may be utilized for the production of various fragrance compounds from plant phenylpropanoids in the future. PMID:22610435

  3. Aerobic Biotransformation of Fluorotelomer Thioether Amido Sulfonate (Lodyne) in AFFF-Amended Microcosms.

    PubMed

    Harding-Marjanovic, Katie C; Houtz, Erika F; Yi, Shan; Field, Jennifer A; Sedlak, David L; Alvarez-Cohen, Lisa

    2015-07-01

    The aerobic biotransformation pathways of 4:2, 6:2, and 8:2 fluorotelomer thioether amido sulfonate (FtTAoS) were characterized by determining the fate of the compounds in soil and medium microcosms amended with an aqueous film-forming foam (AFFF) solution. The biotransformation of FtTAoS occurred in live microcosms over approximately 40 days and produced 4:2, 6:2, and 8:2 fluorotelomer sulfonate (FtS), 6:2 fluorotelomer unsaturated carboxylic acid (FtUCA), 5:3 fluorotelomer carboxylic acid (FtCA), and C4 to C8 perfluorinated carboxylic acids (PFCAs). Two biotransformation products corresponding to singly and doubly oxygenated forms of 6:2 FtTAoS were also identified through high resolution mass spectrometry (MS) analysis and liquid chromatography tandem-MS. An oxidative assay was used to indirectly quantify the total concentration of polyfluorinated compounds and check the mass balance. The assay produced near complete mass recovery of FtTAoS after biotransformation, with 10% (mol/mol) of the amended FtTAoS accounted for in FtS, FtCA, and PFCA products. The transformation rates of identified products appear to be slow relative to FtTAoS, indicating that some intermediates may persist in the environment. This study confirms some of the sources of FtS and PFCAs in groundwater and soil at AFFF-impacted sites and suggests that fluorinated intermediates that are not routinely measured during the biotransformation of PFASs may accumulate. PMID:26042823

  4. Mesenteric involvement of thromboangiitis obliterans (Buerger's disease) in a woman.

    PubMed

    Raat, H; Stockx, L; Broeckaert, L; Rogiers, X; Suy, R; Ectors, N; Ponette, E

    1993-08-01

    Although patients with peripheral arterial occlusive disease due to thromboangiitis obliterans (TAO) have been well characterized and the relationship of this disease to tobacco is stressed, little attention has been focused on its ability to involve the mesenteric vasculature and its ability to affect women. We report a rare case of a known TAO female patient who presented with abdominal pain due to inflammatory changes of the mesenteric vessels. The resulting small bowel ischemic changes and formation of intramural gas were demonstrated on a small bowel follow-through and a plain abdominal film. An angiography finally showed a superior mesenteric artery occlusion. PMID:8294383

  5. 75 FR 29717 - Northern New Mexico Resource Advisory Committee Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-27

    ...m. A second day of the meeting, on June 23, 2010, will begin at 8 a.m. ADDRESSES: The meeting will be held at the Drury Inn, 4310 The 25 Way, NE., in the Taos Room, Albuquerque, New Mexico. Written comments should be sent to Ignacio...

  6. Continuous awareness: A visual mobile approach Cong Chen a

    E-print Network

    Zhang, Kang

    Continuous awareness: A visual mobile approach Cong Chen a , Wenyuan Tao b,n , Kang Zhang b University, China a r t i c l e i n f o Available online 1 August 2013 Keywords: Awareness Mobile visualization Continuous awareness Global software development a b s t r a c t Facing the challenges of global

  7. Camera Calibration from Video of a Walking Human

    E-print Network

    Southern California, University of

    Camera Calibration from Video of a Walking Human Fengjun Lv, Member, IEEE, Tao Zhao, Member, IEEE, and Ramakant Nevatia, Fellow, IEEE Abstract--A self-calibration method to estimate a camera's intrinsic to various viewing angles and subjects. Index Terms--Camera calibration, self-calibration, vanishing point

  8. Monday Tuesday Wednesday Thursday Friday 11 am -12 pm

    E-print Network

    Murdoch, Duncan

    Monday Tuesday Wednesday Thursday Friday 10 - 11 am Anton Iman Jeongbae Tao Yi Wang Azaz Anton Wang Xiaoli Tianhao Hyesoon Yi Wang Jing 1 - 2 pm Changjiang Iman Yanyan Jing Xin Changjiang Iman Yanyan Changjiang Xiaoli Tianhao Iman Yanyan 2 - 3 pm Yingjie Xin Yingjie Jessica Yingjie Yi Zhang

  9. Author's personal copy Mathematical modeling of vertebrate limb development

    E-print Network

    Newman, Stuart A.

    Author's personal copy Review Mathematical modeling of vertebrate limb development Yong-Tao Zhang a 3 December 2012 Keywords: Vertebrate limb development Mathematical model Computational model Multi of vertebrate limb develop- ment and their roles in accounting for different aspects of this process. The main

  10. Universidade Federal do Parana Departamento de Informatica

    E-print Network

    Hexsel, Roberto A

    um artigo cient´ifico, manual, texto informativo, ou um tutorial? Qual ´e o enfoque do texto? Ele ´e Postal 19081 ­ 81531-990 Curitiba, PR roberto@inf.ufpr.br Resumo Este texto foi escrito como uma texto que descreve uma descoberta cient´ifica ou avan¸co t´ecnico ´e uma tarefa t~ao importante quanto o

  11. Chapter 21. Cellular BioMEMS Cellular BioMEMS

    E-print Network

    create. We then take our designs through microfabrication to packaging and testing and to biological Project Staff Joseph Kovac Tao Sun Overview The goal of this research is to develop new technologies. We first plate adherent cells into a dish and identify cells of interest using a microscope, noting

  12. Role of buffer layer in electronic structures of iron phthalocyanine molecules on Au(111) This article has been downloaded from IOPscience. Please scroll down to see the full text article.

    E-print Network

    Gao, Hongjun

    Role of buffer layer in electronic structures of iron phthalocyanine molecules on Au(111 layer in electronic structures of iron phthalocyanine molecules on Au(111) Sun Jia-Tao(), Pan Li layer on Au(111). Keywords: iron phthalocyanine, electronic structure calculations, buffer layer PACC

  13. Killing Mosquitoes and Keeping Practice: Teacher Education as Sustaining Paradox

    ERIC Educational Resources Information Center

    Keiser, David Lee

    2013-01-01

    The moral and ethical charge of teaching and teacher education includes sustaining equanimity and paradox, and maintaining poise amongst contradicting policies and interests. This paper draws upon the wisdom of the Tao Te Ching to address some paradoxes in education and teacher preparation. Specifically, the article looks at four chapters of the…

  14. Curriculum Vitae 2011Present Ph.D. in Physics, Colorado State University, Fort Collins.

    E-print Network

    Sites, James R.

    -V Distortion of CIGS Solar Cells with Sputtered Zn(O,S) Buffer Layers Department of Physics, 1875 CampusTao Song Curriculum Vitae Education 2011­Present Ph.D. in Physics, Colorado State University, Fort Collins. 2011­2013 M.S. in Physics, Colorado State University, Fort Collins. 2007­2011 B.S. in Optical

  15. JOURNAL OF BACTERIOLOGY, 0021-9193/00/$04.00 0

    E-print Network

    Liao, Li

    that ResDE plays a global role in both aerobic and anaerobic respiration. In the absence of nitrate of Bacillus subtilis Grown under Anaerobic Conditions RICK W. YE,* WANG TAO, LAURA BEDZYK, THOMAS YOUNG, MARIO, Delaware 19880 Received 19 January 2000/Accepted 1 June 2000 Bacillus subtilis can grow under anaerobic

  16. Temporal Image Reconstruction in Electrical Impedance Tomography

    E-print Network

    Adler, Andy

    rapid compared to the underlying physiological processes to be imaged, then ensemble averaging mayTemporal Image Reconstruction in Electrical Impedance Tomography Andy Adler1 , Tao Dai1 , William R) calculates images of the body from body impedance measurements. While the spatial resolution of these images

  17. P h y s i c a l O c e a n o g r a p h y D i v i s i o n The PIRATA Northeast Extension

    E-print Network

    States. PIRATA aims to improve our knowledge and understanding of ocean-atmosphere variability, similar to the Tropical Atmosphere-Ocean (TAO) array of the equatorial Pacific. Starting in late 2005 (PNE). The PIRATA backbone of buoys (red squares), the Northeast Extension (blue stars) led

  18. PAMM Proc. Appl. Math. Mech. 11, 783 784 (2011) / DOI 10.1002/pamm.201110380 Variational integrators for electric circuits

    E-print Network

    Ober-Blöbaum, Sina

    2011-01-01

    integrators for electric circuits Sina Ober-Blöbaum1, , Molei Tao2, , and Houman Owhadi2, 1 Computational of mechanical systems. In this work, we develop a variational integrator for the simulation of electric circuits for the simulation of the electric circuit. In this way, a variational integrator is constructed that gains several

  19. A Simple Proof of the Restricted Isometry Property for Random Matrices

    Microsoft Academic Search

    Richard Baraniuk; Mark Davenport; Ronald DeVore; Michael Wakin

    2007-01-01

    We give a simple technique for verifying the Restricted Isometry Property (as introduced by Candes and Tao) for random matrices that underlies Compressed Sensing. Our approach has two main ingredients: (i) concentration inequalities for random inner products that have re- cently provided algorithmically simple proofs of the Johnson-Lindenstrauss lemma, (ii) covering numbers for finite dimensional balls in Euclidean space. This

  20. The Robot Swarm Re-localization Problem Nicolas Bredeche

    E-print Network

    Paris-Sud XI, Université de

    The Robot Swarm Re-localization Problem Nicolas Bredeche TAO / LRI ; Univ Paris-Sud, CNRS, INRIA the problem of re-localization in a swarm of moving virtual robots where some robots might be lost and where the distance between each neighboring robot is known within a limited communication radius (e.g. using

  1. ehirpxf: A Cost-Effective Way to Implement Full Map Directory-Based

    E-print Network

    John, Lizy Kurian

    ehirpxf: A Cost-Effective Way to Implement Full Map Directory-Based Cache Coherence Protocols Tao full map directory tracks the exact caching status for each shared memory block and is designed to be efficient and simple. Unfortunately, the inherent directory size explosion makes it unsuitable for large

  2. Social Network User Influence Dynamics Jingxuan Li1

    E-print Network

    Li, Tao

    Social Network User Influence Dynamics Prediction Jingxuan Li1 , Wei Peng2 , Tao Li1 , and Tong Sun based on Continuous-Time Markov Process to predict the influence dynamics of social network users, where 7808, pp. 310­322, 2013. c Springer-Verlag Berlin Heidelberg 2013 #12;Social Network User Influence

  3. J. Phys. D Appl. Phys. 27 (1994) 1906-1913. Printed in the UK 1 Cylindrical anode double layers

    E-print Network

    Merlino, Robert L.

    1994-01-01

    (`firerods') producedina uniform 1 magneticfield Tao An, R L Merlino and N D'Angelo Depaltment of Physics the ionization potentialof the neutral gas. If a magneticfield of sufficient strength is applied in the direction which we refer to as the `firerod'. The dependenceof the firerod length on magneticfield strength

  4. IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING, VOL. 17, NO. 2, APRIL 2009 107 A Prior Neurophysiologic Knowledge Free

    E-print Network

    Zhang, Liqing

    , Liqing Zhang, Dacheng Tao, Han Sun, and Qibin Zhao Abstract--Single trial electroencephalogram (EEG in analyzing EEG signals, especially in the case of lacking prior neurophysiologic knowledge. Index Terms--Electroencephalogram ELECTROENCEPHALOGRAM (EEG) is a measurement of electrical activity in the brain collected using noninva- sive

  5. 75 FR 34760 - Final Determination for Federal Acknowledgment of the Shinnecock Indian Nation

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-18

    ...2/4/1937), and that the United States did not bring suit on behalf of...Lake Indians from 1911 to 1917 (United States of America v. John W. McGinn...Taos (3 members), and White Mountain Apache Tribe of the Fort...

  6. Response of a coupled ocean-ice-atmosphere model to data assimilation in the tropical zone of the Pacific Ocean

    Microsoft Academic Search

    K. P. Belyaev; N. P. Tuchkova; U. Cubash

    2010-01-01

    This paper deals with numerical experiments based on the coupled ECHAM-HOPE model. The results of experiments are analyzed. The initial fields for the calculations over time periods from one month to one year are constructed based on the results of the data assimilation of temperature profiles from TOGA-TAO moorings. The perturbations of the initial fields and the propagation of these

  7. DEPARTMENT OF ECONOMICS AND FINANCE COLLEGE OF BUSINESS AND ECONOMICS

    E-print Network

    Hickman, Mark

    CHRISTCHURCH, NEW ZEALAND The Impact of Agricultural Technology Adoption of Income Inequality in Rural China IN RURAL CHINA by Shijun Ding*, Laura Meriluoto**, W. Robert Reed**, Dayun Tao***, and Haitao Wu development, Chinese economic development, upland rice, rural-urban income inequality, agricultural income

  8. Materials and Systems Research, Inc. Lessons Learned from SOFC/SOEC Development

    E-print Network

    Materials and Systems Research, Inc. 1 Lessons Learned from SOFC/SOEC Development Greg Gege Tao Early commercialization technology Wider operating temperatures (80ºC for PEM to 800ºC for SOFC) than quality power #12;Materials and Systems Research, Inc. 7 Fuel Cells SOFC based-on oxygen ion conducting

  9. Publications -- Jie Shen

    E-print Network

    Spectral and High-Order Methods with Applications (by Jie Shen and Tao Tang, Science .... L. Chen and V. Gopalan) Surface effect on domain wall width in ferroelectrics. ..... (with S. Wang and T. Tachim Mejdo) On a wind-driven, double-

  10. DOI: 10.1002/zaac.200700505 Syntheses, Structures and Magnetic Properties of Two Mixed-Valent Disc-like

    E-print Network

    Gao, Song

    CH2O)3 3 , nmdea CH3N(CH2CH2O)2 2 ) Tao Liu, Bing-Wu Wang, Yi-Hong Chen, Zhe-Ming Wang*, and Song Gao nuclearity up to 84 [3] * Prof. Zhe-Ming Wang, Prof. Song Gao Beijing National Laboratory for Molecular

  11. Bandit-Based Genetic Programming J.-B. Hoock and O. Teytaud

    E-print Network

    Bandit-Based Genetic Programming J.-B. Hoock and O. Teytaud TAO (Inria), LRI, UMR 8623(CNRS - Univ the validation of randomly generated patterns in a Monte-Carlo Tree Search program. Our bandit-based genetic pro Introduction Genetic Programming (GP) is the automatic building of programs for solving a given task

  12. Slightly beyond Turing's computability for studying genetic programming

    E-print Network

    Paris-Sud XI, Université de

    Slightly beyond Turing's computability for studying genetic programming Olivier Teytaud TAO, INRIA: this is the area of genetic programming (GP) [9, 13, 15]. GP in particular pro- vides many human-competitive results (http://www.genetic-programming. com/humancompetitive.html), and contains 5440 articles by more

  13. Selective suppression of cervical cancer Hela cells by 2-O--D-glucopyranosyl-L-ascorbic acid isolated

    E-print Network

    Engelhardt, John F.

    isolated from the fruit of Lycium barbarum L. Zhiping Zhang & Xiaoming Liu & Tao Wu & Junhong Liu & Xu Abstract Lycium barbarum fruit has been used as a Chinese traditional medicine and dietary supplement . Lycium barbarum fruit . Hela cell . Proteomics Introduction Lycium barbarum fruit is an important

  14. Neuroscience Graduate Program Student Body 2011-2012 NAME OFFICE # LAB # LAB Ext LAB PI E-MAIL

    E-print Network

    Zhang, Li I.

    -JOHN, HANKE LEVITT heunjohn@usc.edu HUANG, CHAO HNB 503 X06471 CELIKEL chaohuan@usc.edu HUEZO-VELASQUEZ, JUAN, WENDY HNB 228 X 05473 MCKEMY wknowlto@usc.edu LEE, JOO-YEUN FIRST YEAR jaemunki@usc.edu LI, LINGYUN TAO

  15. SEA: A Striping-Based Energy-Aware Strategy for Data Placement in RAID-Structured

    E-print Network

    Xie, Tao

    SEA: A Striping-Based Energy-Aware Strategy for Data Placement in RAID-Structured Storage Systems Tao Xie, Member, IEEE Abstract--Many real-world applications need to frequently access data stored has become a salient issue. To achieve energy-conservation and prompt responses simultaneously

  16. MEDIA RELEASE Media contact

    E-print Network

    Machel, Hans

    .m. featuring faculty pianist Patricia Tao and internationally acclaimed guest artists James Campbell (clarinet by internationallyacclaimed artists James Campbell (clarinet) and Gil Sharon (viola) to perform works from Mozart, Brahms with Jasmine Lin (violin) and Marina Hoover (cello) as the spectacular Trio Voce. Together the trio has

  17. Proceedings of Student-Faculty Research Day, CSIS, Pace University, May 7th Improving Web Security Education with Virtual Labs

    E-print Network

    Tappert, Charles

    Web Security Education with Virtual Labs and Shared Course Modules Lixin Tao, Li-Chiou Chen and skills of a web developer to understand many of the web security topics, and some of them are normally virtual machines in supporting hands-on web security education, and developing multiple virtual web

  18. Los Angeles PACIFICOCEAN

    E-print Network

    Stuart, Josh

    , assistive technology, human-computer interaction L. de Alfaro, S. Kurniawan, R. Manduchi, P. Mantey, H. Tao Sensing and Interaction: Computer vision, remote sensing, telemetry, computer-based collaboration Angeles. Computer Engineering @ UC SANTA CRUZ Department of Computer Engineering 1156 High Street Santa

  19. Journal of Atmospheric and Oceanic Technology EARLY ONLINE RELEASE

    E-print Network

    Karnauskas, Kristopher

    influencing global climate. Acoustic Doppler Current Profiler (ADCP) measurements by TAO28 moorings provide, and Depth (CTD), as well as46 horizontal subsurface velocity via Acoustic Doppler Current Profiler (ADCP unique lens in which to cross­validate and better understand several important features50 concurrently

  20. A Cooperative MAC protocol for Ad Hoc Wireless Networks

    E-print Network

    Panwar, Shivendra S.

    A Cooperative MAC protocol for Ad Hoc Wireless Networks Thanasis Korakis, Zhifeng Tao , Yevgeniy. In this paper, we extend a cooperative MAC protocol called CoopMAC [1] into the ad hoc network environment1. Extensive simulations in a large scale wireless ad- hoc network (150 stations) show that CoopMAC

  1. JOURNAL OF GUIDANCE, CONTROL, AND DYNAMICS Vol. 28, No. 6, NovemberDecember 2005

    E-print Network

    Liu, Hugh H.T.

    with Motion Synchronization Jinjun Shan and Hong-Tao Liu University of Toronto, Toronto, Ontario M3H 5T6 Clearance Center, Inc., 222 Rose- wood Drive, Danvers, MA 01923; include the code 0731-5090/05 $10@utias.utoronto.ca. Associate Professor, Institute for Aerospace Studies, 4925 Dufferin Street; liu@utias.utoronto.ca. Member

  2. Efficient encoding and rapid decoding for interactive visualization of large three-dimensional hyperspectral

    E-print Network

    Reichenbach, Stephen E.

    -dimensional hyperspectral chemical images Stephen E. Reichenbach1*, Alex Henderson2 , Robert Lindquist1 and Qingping Tao3 1, Manchester M1 7DN, UK 3 GC Image, LLC, Lincoln, NE 68506, USA Received 28 October 2008; Revised 23 January imaging systems requires coding that is efficient and accessible. New technologies for secondary ion mass

  3. CONSTELLATIONS IN Pd BRIAN COOK AKOS MAGYAR

    E-print Network

    Magyar, Akos

    CONSTELLATIONS IN Pd BRIAN COOK ´AKOS MAGYAR Abstract. Let A be a subset of positive relative upper such a result was obtained by Tao [9], showing that the Gaussian primes contain arbitrary constellations. In the same paper the problem of finding constellations in dense subsets of Pd was raised and briefly

  4. Quantum simulation of small-polaron formation with trapped ions Vladimir M. Stojanovic,1,

    E-print Network

    Bruder, Christoph

    Quantum simulation of small-polaron formation with trapped ions Vladimir M. Stojanovi´c,1, Tao Shi, 85748 Garching, Germany (Dated: July 9, 2012) We propose a method for simulating polaron physics using by the formation of small polarons, can be reached using realistic values of the relevant system parameters

  5. Software News and Updates A Toolkit to Assist ONIOM Calculations

    E-print Network

    Schlegel, H. Bernhard

    Software News and Updates A Toolkit to Assist ONIOM Calculations PENG TAO, H. BERNHARD SCHLEGEL to facilitate ONIOM-type QM/MM calculations is described. This toolkit is designed to assist in the different stages of an ONIOM QM/MM study of biomolecules, including input file preparation and checking, job

  6. NREL is a national laboratory of the U.S. Department of Energy Office of Energy Efficiency & Renewable Energy

    E-print Network

    & Renewable Energy Operated by the Alliance for Sustainable Energy, LLC. This report is available at no cost from the National Renewable Energy Laboratory (NREL) at www.nrel.gov/publications. Contract No. DE-AC36 to Hydrocarbons R. Davis, L. Tao, E.C.D. Tan, M.J. Biddy, G.T. Beckham, and C. Scarlata National Renewable Energy

  7. Supplementary Fig. 1. Geographical definition of the fourteen regions. NPO North Pacific Ocean, NAM North America, NAO North Atlantic Ocean, EUR Europe, ASI Asia, TPO

    E-print Network

    Meskhidze, Nicholas

    , NAM ­ North America, NAO ­ North Atlantic Ocean, EUR ­ Europe, ASI ­ Asia, TPO ­ Tropical Pacific Ocean, TAO ­ Tropical Atlantic Ocean, AFR ­ Africa, TIO ­ Tropical Indian Ocean, SPO ­ South Pacific Ocean, SAM ­ South America, SAO ­ South Atlantic Ocean, SIO ­ South Indian Ocean, OCE ­ Oceania. 5 #12

  8. THE JOURNAL OF CHEMICAL PHYSICS 135, 094304 (2011) "Adiabatic-hindered-rotor" treatment of the parahydrogen-water complex

    E-print Network

    Le Roy, Robert J.

    2011-01-01

    THE JOURNAL OF CHEMICAL PHYSICS 135, 094304 (2011) "Adiabatic-hindered-rotor" treatment of the parahydrogen-water complex Tao Zeng,1 Hui Li,2 Robert J. Le Roy,1 and Pierre-Nicholas Roy1,a) 1 Department 1 September 2011) Inspired by a recent successful adiabatic-hindered-rotor treatment

  9. Investigation of combustive flows and dynamic meshing in computational fluid dynamics 

    E-print Network

    Chambers, Steven B.

    2005-02-17

    to thank my peers: Roshawn Bowers, Joaquin Gargolo?, Jason Guarnieri, Kyu-sup Kim, Aditya Murthi, Josh O'Neil, Celerino Resendiz, Amarnath Sambasivam, Leslie Weitz, and Tao Yuan. Lastly, I would like to thank my family. Without their love and support, none...

  10. Novel Artificial Neural Networks For Remote-Sensing Data Classification

    E-print Network

    Michel, Howard E.

    Novel Artificial Neural Networks For Remote-Sensing Data Classification Xiaoli Tao* and Howard E artificial neural network architectures applied to multi-class classification problems of remote-sensing data. These approaches are 1) a spiking-neural-network model for the partitioning of data into clusters, and 2) a neuron

  11. Processing Landsat TM Data Using Complex-Valued NRBF Neural Network

    E-print Network

    Michel, Howard E.

    Processing Landsat TM Data Using Complex- Valued NRBF Neural Network Xiaoli Tao Howard E. Michel classification technique -- a Complex-Valued Normalized Radial Basis Function (NRBF) neural network classifier. Complex-valued weights are used in the supervised learning part of NRBF neural networks. Different from

  12. Shape-specific polymeric nanomedicine: emerging opportunities and challenges

    E-print Network

    Hu, Wenchuang "Walter"

    Minireview Shape-specific polymeric nanomedicine: emerging opportunities and challenges Li Tao1 for nanomedicine applications. Extensive studies have revealed the effect of particle size on spherical particles the performance of nanomedicine in diagnostic imaging and targeted drug delivery applications. Keywords: shape

  13. LETTER Communicated by Rajesh Rao Optimal Spike-Timing-Dependent Plasticity for Precise Action

    E-print Network

    Senn, Walter

    for synaptic depression under reversed spike timing. In fact, the presence and amplitude of depression­1348 (2006) C 2006 Massachusetts Institute of Technology #12;Optimal STDP in Supervised Learning 1319 timed is reversed, the synapse is depressed (Markram, L¨ubke, Frotscher, & Sakmann, 1997; Zhang, Tao, Holt, Harris

  14. Differentiated Contention Resolution for QoS in Photonic Packet-Switched Networks

    E-print Network

    Jue, Jason P.

    , photonic packet-switched networks have been proposed, in which data packets can be transmittedDifferentiated Contention Resolution for QoS in Photonic Packet-Switched Networks Tao Zhang, Kejie resolution in photonic packet-switched networks by exploiting recirculation buffering and deflection routing

  15. Tropical Atmosphere Ocean Project: El Nino and La Nina 3-D Visualizations

    NSDL National Science Digital Library

    Users can view a selection of animations of ocean surface temperature and dynamic height derived from data from the TAO/TRITON buoy array moored in the Pacific Ocean. The animations show temperature and surface topography variations consistent with the development of El Nino and La Nina events.

  16. DeepSentiBank: Visual Sentiment Concept Classification with Deep Convolutional Neural Networks

    E-print Network

    Chang, Shih-Fu

    Net. Our deep CNNs model is trained based on Caffe, a newly developed deep learning framework. To deal Retrieval and Indexing Keywords deep learning, visual sentiment, affective computing 1. INTRODUCTIONDeepSentiBank: Visual Sentiment Concept Classification with Deep Convolutional Neural Networks Tao

  17. Tool-Assisted Unit-Test Generation and Selection Based on Operational Abstractions

    E-print Network

    Xie, Tao

    Tool-Assisted Unit-Test Generation and Selection Based on Operational Abstractions Tao Xie1 of Washington, Seattle, WA 98105 Abstract. Unit testing, a common step in software development, presents a chal- lenge. When produced manually, unit test suites are often insufficient to identify defects. The main

  18. nanoparticles water-soluble and biocompatible.The polyethylene gly-col chains are terminated with primary amines to facilitate synthetic

    E-print Network

    Cai, Long

    , Sean P Orton, SethT Gammon, Wenyi Che, Gilbert D Feke,Tao Ji, M Catherine Muenker, Megan Schmidt,Victoria Jacobs, DouglasVizard & William McLaughlin Carestream Molecular Imaging, New Haven, Connecticut, USA. Correspondence should be addressed to W.M. (william.mclaughlin@carestreamhealth.com). a b c d Figure 1 | Near

  19. www.nature.com/naturemethods nature methods | VOL.6 NO.6 | JUNE 2009

    E-print Network

    Cai, Long

    : traps for the unwary William Ritchie, Stephane Flamant & John E J Rasko research hiGhliGhts 401 for longitudinal cell tracking in mice W Matthew Leevy, Sean P Orton, Seth T Gammon, Wenyi Che, Gilbert D Feke, Tao Ji, M Catherine Muenker, Megan Schmidt, Victoria Jacobs, Douglas Vizard & William McLaughlin vii

  20. Incorporating Game-theoretic Rough Sets in Web-based Medical Decision Support Systems

    E-print Network

    Yao, JingTao

    Incorporating Game-theoretic Rough Sets in Web-based Medical Decision Support Systems JingTao Yao with the modern Web technology. An important branch of WSS is Web-based decision support systems that provide intelligent support for decision making tasks. We focus on decision making in Web-based medical decision

  1. The Moon Beyond 2002: Next Steps in Lunar Science and Exploration

    NASA Technical Reports Server (NTRS)

    2002-01-01

    This volume contains abstracts that have been accepted for presentation at the conference on The Moon Beyond 2002: Next Steps in Lunar Science and Exploration, September 12-14, 2002, in Taos, New Mexico. Administration and publications support for this meeting were provided by the staff of the Publications and Program Services Departments at the Lunar and Planetary Institute.

  2. Restriction theorems for a surface with negative curvature

    Microsoft Academic Search

    Ana Vargas; Facultad Ciencias

    2005-01-01

    We prove a bilinear restriction theorem for a surface of negative curvature. This is the analogue of the results of T. Wolff [19] and T. Tao [14], [15] for cones and paraboloids. As a consequence we obtain an almost sharp linear restriction theorem.

  3. Safety-Ensured Coordination of Networked Medical Devices in MDPnP

    E-print Network

    Hu, Fei

    Safety-Ensured Coordination of Networked Medical Devices in MDPnP Tao Li, and Jiannong Cao,csjcao}@comp.polyu.edu.hk Abstract--In recent years, research on medical device inte- gration has attracted a lot of attentions in this research is the Medical Device Plug-and-Play (MDPnP) Interoperability program. The continuous effort

  4. Convergence Analysis for Operator Splitting Methods to Conservation Laws with Stiff Source Terms

    E-print Network

    , first­order dimensional splitting method was intro­ duced by Godunov [7], which was modified by Strang Tao Tang \\Lambda Department of Mathematics and Statistics, Simon Fraser University Burnaby, British Columbia, Canada V5A 1S6 September 3, 1996 Abstract We analyze the order of convergence for operator

  5. The Rainmaker's Reality and the Holographic Archetype

    Microsoft Academic Search

    Joseph W. Burke

    2007-01-01

    Recalling the rainmaker story often told by Jung, this article connects the rainmaker's view of reality with a holographic archetype. In the story, rain comes to a drought-stricken area of China when a rainmaker gets in Tao, in order, within himself. He insists he is not responsible for the rain, though the villagers sent for him due to his reputation

  6. International Journal of Computer Vision 69(2), 181201, 2006 c 2006 Springer Science + Business Media, LLC. Manufactured in The Netherlands.

    E-print Network

    Gong, Shaogang

    . Extensive experiments on learning visual context for dynamic scene modelling are carried out to demonstrateInternational Journal of Computer Vision 69(2), 181­201, 2006 c 2006 Springer Science + Business for Unsupervised Learning of Visual Context TAO XIANG AND SHAOGANG GONG Department of Computer Science, Queen Mary

  7. An Enhanced Support Vector Machine Model for Intrusion Detection

    E-print Network

    Yao, JingTao

    An Enhanced Support Vector Machine Model for Intrusion Detection JingTao Yao, Songlun Zhao [jtyao,zhao200s,fan]@cs.uregina.ca Abstract. Design and implementation of intrusion detection systems Machines (SVM) as a classical pattern recognition tool have been widely used for intrusion detection

  8. Using ACL2 to Verify Security Properties of Specification-based Intrusion Detection Systems

    E-print Network

    California at Davis, University of

    Using ACL2 to Verify Security Properties of Specification- based Intrusion Detection Systems Tao Intrusion detection is considered to be an effective technique to detect attacks that violate the security policy of systems. There are basically three different kinds of intrusion detection: Anomaly detection

  9. Geometric Representation and Grouping of Image Curves

    E-print Network

    Cham, Tat Jen

    Geometric Representation and Grouping of Image Curves Tat-Jen Cham St Catharine's College August 35,000 words in this dissertation. Tat Jen Cham St. Catharine's College #12;#12;To my parents, Ee-Lin and Tao-Soon Cham, with heartfelt love and gratitude #12;#12;Abstract Perceptual organisation, while

  10. WORKING QUANTUM EFFICIENCY OF CDTE SOLAR CELL Zimeng Cheng

    E-print Network

    Chen 1 , Tao Zhou 2 , Qi Wang 3 , George E. Georgiou 1 , Ken K. Chin 1 1 Apollo CdTe Solar Energy Renewable Energy Laboratory (NREL), Golden, CO 80401 USA ABSTRACT For p-CdTe/n-CdS solar cell but also most importantly voltage dependent, since the CdTe solar cell is believed to be the diode which

  11. Exploring the Potential for High-Quality Epitaxial CdTe Solar Cells , Ana Kanevce2

    E-print Network

    Sites, James R.

    Exploring the Potential for High-Quality Epitaxial CdTe Solar Cells Tao Song1 , Ana Kanevce2 National Renewable Energy Laboratory, Golden, CO, 80401, USA Abstract -- Traditional polycrystalline CdTeV and ~ 20%. Epitaxial CdTe with high-quality, low defect-density, and high carrier density, could yield

  12. KissKissBan: A Competitive Human Computation Game for Image Annotation

    E-print Network

    Chen, Sheng-Wei

    KissKissBan: A Competitive Human Computation Game for Image Annotation Chien-Ju Ho1 , Tao computation game, KissKissBan (KKB), for image annotation. KKB is different from other human computation games- pose, Human Computation, Image Annotation 1. INTRODUCTION Since the introduction of the ESP Game, Games

  13. Single crystalline tantalum oxychloride microcubes: controllable synthesis, formation mechanism and enhanced photocatalytic hydrogen production activity.

    PubMed

    Tu, Hao; Xu, Leilei; Mou, Fangzhi; Guan, Jianguo

    2015-07-21

    Single crystalline microcubes of a new tantalum compound, tantalum oxychloride (TaO2.18Cl0.64), have been fabricated hydrothermally in a concentrated aqueous solution of hydrochloric acid and acetic acid. They contain a superstructure and exhibit remarkably enhanced photocatalytic activities for hydrogen production due to the improved light harvest and facilitated charge transport. PMID:26143863

  14. Loss of Heterozygosity of the Rb Gene Correlates with pRb Protein Expression and Associates with p53 Alteration in Human

    E-print Network

    Xing, Eric P.

    53 Alteration in Human Esophageal Cancer1 Eric Poe Xing,2 Guang-Yu Yang,2 Li-Dong Wang, Stephanie Tao- nohistochemical and genetic analyses, we found that alter- ation of Rb and p53 had an even stronger association, Zhengzhou, 457500 China [L-D. W.] ABSTRACT To understand the alterations of Rb tumor suppressor gene

  15. Syllabus STOR 655 Spring 2012 (January 9 April 28)

    E-print Network

    Hannig, Jan

    Syllabus ­ STOR 655 Spring 2012 (January 9 ­ April 28) MW 2:00-3:15p Hanes 125 Instructor: Jan and by appointment Course home page on http://www.unc.edu/~hannig/STOR655 Teaching Assistant: Tao Wang E-mail: taow

  16. Real-time event channel performance on a submarine communications network

    Microsoft Academic Search

    S. W. Talbert; A. C. Weaver

    2002-01-01

    This project evaluated the real-time event channel of the TAO software when running under the Sun Solaris 8 operating system. We modeled the communications channel among the RTS, NAV, and SONR units taken from the shipboard network architecture design for Virginia-class submarines. We established a baseline set of performance measurements for throughput, latency and jitter, communicating over UDP, TCP, and

  17. Digital tomosynthesis mammography using a parallel maximum likelihood reconstruction method

    E-print Network

    Meleis, Waleed

    Digital tomosynthesis mammography using a parallel maximum likelihood reconstruction method Tao Wu tomosynthesis mammography. Tomosynthesis mammography acquires 11 low-dose projections of a breast by moving an x are retrospectively reconstructed from a single scan. Tomosynthesis mammography has been investigated to solve

  18. Educational Software Engineering: Where Software Engineering, Education, and Gaming Meet

    E-print Network

    Xie, Tao

    Educational Software Engineering: Where Software Engineering, Education, and Gaming Meet Tao Xie and advocate the subfield of educational software engineering (i.e., software engineering for education), which develops software engineering technologies (e.g., software testing and analysis, software analytics

  19. Software Analytics in Practice Dongmei Zhang, Shi Han, Yingnong Dang, Jian-Guang Lou, Haidong Zhang, Microsoft Research Asia,

    E-print Network

    Xie, Tao

    Software Analytics in Practice Dongmei Zhang, Shi Han, Yingnong Dang, Jian-Guang Lou, Haidong Zhang, Microsoft Research Asia, China Tao Xie, University of Illinois at Urbana-Champaign, USA Abstract: Software analytics is to utilize data-driven approaches to enable software practitioners to perform data exploration

  20. nAture methods | VOL.11 NO.6 | JUNE2014 | 657 molecular biologists routinely clone genetic constructs from

    E-print Network

    Cai, Long

    -ligation­based and homologous recombination­based cloning systems, and many follow the design model of assembling genetic model, two fundamental questions arise: First, how should we identify and select parts to create Evan Appleton1,2, Jenhan Tao3, Traci Haddock2 & Douglas Densmore1,2,4 binary assembly methods typically

  1. Retrieval Algorithms for Estimating the Vertical Profiles of Latent Heat Release: Their Applications for TRMM

    Microsoft Academic Search

    Wei-Kuo Tao; S. Lang; Joanne Simpson; Robert F. Adler

    1993-01-01

    The latent heat release is a consequence of phase change (vapor, liquid and solid) of water. An algorithm has been developed (Tao et al., 1990) to estimate the latent heating of cloud systems as a function of their vertical hydrometeor profiles (termed a hydrometeor\\/heating algorithm). The derivation as well as the validation of the algorithm was based on results of

  2. Estimating the Proportion of False Null Hypotheses among a Large Number of

    E-print Network

    Rice, John

    Hypotheses Nicolai Meinshausen John Rice October 14, 2004 Abstract We consider the problem of estimating might be an attempt to detect an independent realization of a rare signal and the number of actual enough light back to earth to be directly observed. The purpose of the TAOS project is to estimate

  3. Directional Wavelet Approach to Remove Document Image Interference , Chew Lim Tan1

    E-print Network

    Tan, Chew Lim

    not require double-sided mapping but instead uses a directional wavelet transform to distinguish is not efficient enough to be used in real-time applications. We later proposed a wavelet transform [7] to sharpenDirectional Wavelet Approach to Remove Document Image Interference Qian Wang1 , Tao Xia2 , Chew Lim

  4. Design of a broadband highly dispersive pure silica photonic crystal fiber

    E-print Network

    Chen, Ray

    for high-dispersion application in phased array antenna systems based on photonic crystal fiber arraysDesign of a broadband highly dispersive pure silica photonic crystal fiber Harish Subbaraman,1 Tao-concentric-core pure silica photonic crystal fiber is designed with a maximum chromatic dispersion value of about 9500

  5. 4th World Climate Research Program International Conference on Reanalyses Silver Spring, MD, May 07-11, 2012

    E-print Network

    trajectory is available to estimate bckground covariances #12;3 EnKF alternatives · Steady state ensemble (a CTD PIRATA RAMA ARGO Experimental context · Model: · GFDL MOM4p1 (OGCM component of GEOS-5 modeling: 2010-2011 · Data assimilated: - Temperature profiles from ARGO, TAO, XBT, CTD & RAMA - Ice fractional

  6. Quantized plasmon quenching dips

    E-print Network

    Cai, Long

    Quantized plasmon quenching dips nanospectroscopy via plasmon resonance energy transfer Gang Logan Liu1­4, Yi-Tao Long1,4, Yeonho Choi1, Taewook Kang1 & Luke P Lee1,2 We observed quantized plasmon quenching dips in resonant Rayleigh scattering spectra by plasmon resonance energy transfer (PRET) from

  7. BIOLOGICALLY-INSPIRED OBJECT RECOGNITION SYSTEM WITH FEATURES FROM COMPLEX WAVELETS

    E-print Network

    Kingsbury, Nick

    researchers have studied the field, the scale-invariant fea- ture transform (SIFT) [4] was developed and shownBIOLOGICALLY-INSPIRED OBJECT RECOGNITION SYSTEM WITH FEATURES FROM COMPLEX WAVELETS Tao Hong, Nick the extraction of sta- ble local features; good directional selectivity, which simplifies the determination

  8. Comment/Rebuttal Comments on "Electrorheology Leads to Efficient Combustion" by

    E-print Network

    Gülder, Ömer L.

    Comment/Rebuttal Comments on "Electrorheology Leads to Efficient Combustion" by Tao et al. O¨ mer L of combustion in general and internal combustion (IC) engine combustion technology in particular. Given posit that "because combustion starts at the interface between fuel and air and most harmful emissions

  9. SHARP: A New Real-Time Scheduling Algorithm to Improve Security of Parallel Applications on Heterogeneous Clusters

    E-print Network

    Qin, Xiao

    on Heterogeneous Clusters Tao Xie, Xiao Qin ,and Mais Nijim Department of Computer Science New Mexico Institute on heterogeneous clusters. We propose a new security- and heterogeneity-driven scheduling algo- rithm (SHARP without any risk of being attacked. Because of high security overhead in existing clusters, an im- portant

  10. IEEE TRANSACTIONS ON COMPUTERS, MANUSCRIPT ID 1 Scheduling Security-Critical Real-Time

    E-print Network

    Qin, Xiao

    on Clusters Tao Xie, Student Member, IEEE, and Xiao Qin, Member, IEEE Abstract-- Security-critical real running on clusters demand both real-time performance and security, we investigate the problem-critical tasks. Next, we propose a security-aware real-time heuristic strategy for clusters (SAREC), which

  11. Scheduling Security-Critical Real-Time Applications on Clusters

    E-print Network

    Xie, Tao

    Scheduling Security-Critical Real-Time Applications on Clusters Tao Xie, Member, IEEE, and Xiao Qin performance. In recognition that many applications running on clusters demand both real-time performance strategy for clusters (SAREC), which integrates security requirements into the scheduling for real- time

  12. impact of environmental forcing on the acoustic backscattering strength

    E-print Network

    ) · meteo (TAO) · moon phases, sun and moon rise and set times (US Naval Observatory) #12;the equatorial Pacificthe equatorial Pacific Sv variations · different time-scales · light (diurnal cycle, moon cycle power at moon frequency 170m 40m Z20°C high energy · in the thermocline (Z20°C) · at frequency

  13. New dynamic zoom calibration technique for a stereo-vision based multi-view 3D modeling system

    E-print Network

    Subbarao, Murali "Rao"

    New dynamic zoom calibration technique for a stereo-vision based multi-view 3D modeling system Tao models obtained with our techniques are presented. Keywords: Stereo vision, 3D modeling, dynamic zoom for calibrating a 3D modeling system with variable zoom based on multi-view stereo image analysis. The 3D modeling

  14. NTT DoCoMo USA Labs, Inc. Copyright 2005-2006

    E-print Network

    Baeza-Yates, Ricardo

    TAO Reification points Meta level protocol Base level skeleton Dynamic Software Updates Michael Hicks, U software management Innopath Bitfone Redbend mFormation Reflective middleware OpenORB, dynamic Extensible management policy Explicit exposure of runtime details Software architecture descriptors #12;NTT

  15. The Substation of the Future: A Feasibility Study

    E-print Network

    of Technology Anjan Bose, Washington State University PSERC Publication 10-17 October 2010 #12;Information about is available for downloading from the PSERC website. 2010 Georgia Institute of Technology and Washington State of the reports: Sungyun Choi Curtis Roe Georgia Institute of Technology Tao Yang Washington State University

  16. research papers 1260 Simpson et al. Bacteriophage 929 headtail connector Acta Cryst. (2001). D57, 12601269

    E-print Network

    Tao, Yizhi Jane

    2001-01-01

    research papers 1260 Simpson et al. Bacteriophage 929 head±tail connector Acta Cryst. (2001). D57 determination of the head±tail connector of bacteriophage u29 Alan A. Simpson,a Petr G. Leiman,a Yizhi Tao of Crystallography Printed in Denmark ± all rights reserved The head±tail connector of bacteriophage 929 is composed

  17. Published at the 12th International Conference on Pattern Recognition, Israel, October 1994. An Effective Image Thresholding Method Using a Fuzzy

    E-print Network

    . An Effective Image Thresholding Method Using a Fuzzy Compactness Measure Wenjing Tao Hans Burkhardt Technische this method to segment the re­ gions of interesting of flame images is also demon­ strated. 1 Introduction Gray level thresholding is one of the popular tech­ niques for image segmentation. A variety of thresh

  18. Lithographically defined uniform worm-shaped polymeric nanoparticles This article has been downloaded from IOPscience. Please scroll down to see the full text article.

    E-print Network

    Hu, Wenchuang "Walter"

    Lithographically defined uniform worm-shaped polymeric nanoparticles This article has been.1088/0957-4484/21/9/095301 Lithographically defined uniform worm-shaped polymeric nanoparticles L Tao1 , X M Zhao1 , J M Gao2 and W Hu1,3 1 combined with photolithography on a bi-layer polymer setup to define nano-worms laterally in nano

  19. Computer Science MAPO: Mining API Usages from

    E-print Network

    Xie, Tao

    Computer Science MAPO: Mining API Usages from Open Source Repositories Tao Xie Department of Computer Science North Carolina State University, USA Jian Pei Department of Computer Science Simon Fraser University, Canada ·http://ase.csc.ncsu.edu/ #12;Computer Science Learning API Usages is Challenging ·org

  20. Well-posedness for the heat flow of polyharmonic maps with rough initial data

    E-print Network

    Wang, Changyou

    Well-posedness for the heat flow of polyharmonic maps with rough initial data Tao Huang Changyou Wang Abstract We establish both local and global well-posedness of the heat flow of polyharmonic maps for m = 2. Motivated by the study of heat flow of harmonic and biharmonic maps, we consider the heat

  1. Microwave and Terahertz wave sensing with metamaterials

    E-print Network

    Zhang, Xin

    Microwave and Terahertz wave sensing with metamaterials Hu Tao,1 Emil A. Kadlec,2 Andrew C designed, fabricated, and characterized metamaterial enhanced bimaterial cantilever pixels for far codes: (160.3918) Metamaterials; (040.2235) Detectors, Far infrared or terahertz; (050.6875) Three

  2. u p p l e m e n t This document is a supplement to "RAMA:The

    E-print Network

    Downwelling shortwave radiation Eppley PSP-TAO, Delrin case 200­1000 W m-2 0.4 W m-2 ±2% Downwelling longwave shortwave radiation Eppley PSP 0­1400 W m-2 0.01 W m-2 ±1­3% (*) Measurement Model Range Resolution Accuracy

  3. Black-Box Optimization Benchmarking the IPOP-CMA-ES on the Noiseless Testbed

    E-print Network

    Paris-Sud XI, Université de

    Black-Box Optimization Benchmarking the IPOP-CMA-ES on the Noiseless Testbed Comparison to the BIPOP-CMA-ES Raymond Ros TAO Team-Project ­ INRIA Saclay LRI, Bat 490, Univ. Paris-Sud F-91405 Orsay-Evolution Strategy (CMA-ES) algorithm with an Increasing POPu- lation size (IPOP) restart policy on the BBOB

  4. EEL 5764 Computer Architecture 1. Catalog Description (3 credits) Fundamentals in design and quantitative analysis of

    E-print Network

    Fang, Yuguang "Michael"

    . Instructor ­ Dr. Tao Li a. Office location: 339D Larsen Hall b. Telephone: 352-392-9510 c. E-mail address and Supply Fees - None #12;12. Textbooks and Software Required - a. Title: Computer Architecture. ISBN number: 0-07-057064-7 14. Course Outline ­ Fundamentals of Computer Design Performance, Power

  5. Meta online learning: experiments on a unit commitment problem

    E-print Network

    Paris-Sud XI, Université de

    Meta online learning: experiments on a unit commitment problem Jialin Liu and Olivier Teytaud TAO.liu@lri.fr Abstract. Online learning is machine learning, in real time from suc- cessive data samples. Meta online learning consists in combining several online learning algorithms from a given set (termed portfolio

  6. Real-time prediction of the reversibility of the ultrasound-induced blood-brain barrier opening using passive cavitation detection with MRI validation

    E-print Network

    Konofagou, Elisa E.

    using passive cavitation detection with MRI validation Tao Sun1 , Gesthimani Samiotaki1 and Elisa E, represented by the cavitation dose, as monitored during BBB opening to the reversibility of BBB opening). A single-element, pulse-echo ultrasound transducer served as a passive cavitation detector was used

  7. Prediction of the reversibility of the ultrasound-induced blood-brain barrier opening using passive cavitation detection with magnetic resonance imaging

    E-print Network

    Konofagou, Elisa E.

    cavitation detection with magnetic resonance imaging validation Tao Sun1 , Gesthimani Samiotaki1 and Elisa E (diameters: 1-2, 4-5, or 6-8 m). A 10-MHz passive cavitation detector was used to acquire cavitation signals that the stable cavitation dose increased with the number of days required for closing while it reached a plateau

  8. Flexible Terahertz Metamaterials: Towards a Terahertz Metamaterial Invisible Cloak , N. I. Landy2

    E-print Network

    Flexible Terahertz Metamaterials: Towards a Terahertz Metamaterial Invisible Cloak Hu Tao1 , N. I In this work, we present flexible metamaterials on free standing polyimide substrates operating at terahertz (THz) frequencies range. The successful demonstration of THz flexible metamaterials provides a path

  9. We Shared the Same Chapter: Collaboration, Learning, and Transformation from the 2008 Subsistence, the Environment, and Community Well-Being Native Youth Exchange in Old Harbor, Alaska Project

    ERIC Educational Resources Information Center

    Richmond, Laurie; Di Piero, Daniela; Espinoza, Flowers; Simeonoff, Teacon; Faraday, Margaret

    2010-01-01

    On a small island belonging to the Alutiiq people of Old Harbor, 11 people sat around a campfire. Two community leaders, a nonprofit organizer, an academic scholar, a native filmmaker, and six young people from the Indian reservation of Taos Pueblo in New Mexico gathered after a day of interacting with Old Harbor residents--fishing, hunting and…

  10. ENGLISH LEARNING STRATEGY USE BY ELEMENTARY SCHOOL STUDENTS

    Microsoft Academic Search

    Shiu-chen Hsu

    This study investigates the effects of gender, parents' education level and learning experience out of school on English learning strategy use. The subjects are 82 sixth grade elementary school students in Tao-Yuan county. The instrument is an English learning questionnaire modified from Oxford's Strategy Inventory for Language Learning. According to the results, the elementary school students do use learning strategies

  11. IEEE TRANSACTIONS ON WIRELESS COMMUNICATIONS, ACCEPTED FOR PUBLICATION 1 MSE-Based Transceiver Designs for the

    E-print Network

    Tao, Meixia "Melissa"

    in the Proceedings of IEEE WCNC 2010. H. Shen and B. Li are with the Department of Corporate Research, Huawei Technologies Co. Ltd., Shenzhen, P.R. China (e-mail: nickshenhui@sina.com, binli@huawei.com). M. Tao

  12. A Survey on Wavelet Applications in Data Mining Department of

    E-print Network

    Li, Tao

    A Survey on Wavelet Applications in Data Mining Tao Li Department of Computer Science Univ in the use of wavelet methods in various data mining processes. However, there has been written presents a high-level data-mining framework that reduces the overall process into smaller components

  13. Imaging the electrocatalytic activity of single nanoparticles

    E-print Network

    Reisslein, Martin

    Imaging the electrocatalytic activity of single nanoparticles Xiaonan Shan1,2 , Ismael Di, Qihuang Gong4, Jinghong Li5 * and Nongjian Tao1,2 * 1 The electrocatalytic properties of nanoparticles the total electrocatalytic 4 reaction current of a large number of nanoparticles, but this 5 approach

  14. Comma Restoration Using Constituency Information Stuart M. Shieber

    E-print Network

    Shieber, Stuart

    Comma Restoration Using Constituency Information Stuart M. Shieber Harvard University shieber@deas.harvard.edu Xiaopeng Tao Harvard University xptao@deas.harvard.edu Abstract Automatic restoration of punctuation from the performance of an HMM-based system for restoring punctuation (specifically, commas) in text. Our best methods

  15. Block SAPOR: Block Second-Order Arnoldi Method for Passive Order Reduction of Multi-Input Multi-Output RCS Interconnect Circuits

    E-print Network

    Bai, Zhaojun

    -Output RCS Interconnect Circuits Bang Liu1 , Xuan Zeng1 , Yangfeng Su2 , Jun Tao1 , Zhaojun Bai3 , Charles many research interests for the simulation of RCS interconnect circuits employing susceptance elements) for Multi-Input Multi-Output RCS Circuits. The proposed Block SAPOR algorithm can simultaneously guarantee

  16. Hierarchical self-assembly of DNA into symmetric supramolecular polyhedra

    E-print Network

    Jiang, Wen

    LETTERS Hierarchical self-assembly of DNA into symmetric supramolecular polyhedra Yu He1 , Tao Ye1 approach to forming DNA polyhedra is a one-pot self- assembly process illustrated in Fig. 1: individual then further assemble into polyhedra through sticky-end asso- ciation between the tiles. The three

  17. Recursive Turtle Programs and Iterated Affine Transformations

    E-print Network

    Schaefer, Scott

    Recursive Turtle Programs and Iterated Affine Transformations Tao Ju*, Scott Schaefer, Ron Goldman of equivalence between the class of fractals created by Recursive Turtle Programs (RTP) and Iterated Affine, turtle graphics 1 Introduction In computer graphics, there are several different methods for generating 2

  18. Measuring OS Support for Real-time CORBA ORBs

    E-print Network

    Schmidt, Douglas C.

    and evaluates the suitability of real- time operating systems, VxWorks and LynxOS, and general- purpose makes it unsuitable for real-time applications. Both LynxOS and VxWorks do enable predictable- dictability of TAO in several real-time operating systems, i.e., VxWorks and LynxOS, and operating systems

  19. Ultra-tightly Coupled GPS/Vehicle Sensor Integration for Land Vehicle Navigation

    E-print Network

    Calgary, University of

    Ultra-tightly Coupled GPS/Vehicle Sensor Integration for Land Vehicle Navigation TAO LI, MARK G, and attitude information. This paper investigates an ultra-tight integration strategy to fuse GPS and a vehicle the fea- sibility of implementing the proposed system. Results demonstrate that the ultra-tight approach

  20. Activity Based Video Content Trajectory Representation and Segmentation

    E-print Network

    Gong, Shaogang

    -line segmentation algorithms. Its performance is compared to that of two off-line algorithms on surveillance videos representation is superior to a colour histogram based representation for surveillance video segmentation. 1Activity Based Video Content Trajectory Representation and Segmentation Tao Xiang and Shaogang Gong

  1. REMARKS ON THE CAUCHY PROBLEM FOR THE ONE-DIMENSIONAL QUADRATIC (FRACTIONAL) HEAT EQUATION

    E-print Network

    Boyer, Edmond

    REMARKS ON THE CAUCHY PROBLEM FOR THE ONE-DIMENSIONAL QUADRATIC (FRACTIONAL) HEAT EQUATION LUC quadratic (fractional) heat equation: ut = D2 x u u2 , t (0, T), x R or T, with 0 introduced by Bejenaru-Tao [1] for a one-dimensional quadratic Schr¨odinger equation. This approach is based

  2. PROSPECT-PSPP: an automatic computational pipeline for protein structure prediction

    E-print Network

    PROSPECT-PSPP: an automatic computational pipeline for protein structure prediction Jun-tao Guo1 generation. The centerpiece of the pipe- line is our threading-based program PROSPECT. The pipeline with the production rate of protein sequences due to the limitations of the current technology. Computational

  3. Atmos. Chem. Phys., 10, 97979817, 2010 www.atmos-chem-phys.net/10/9797/2010/

    E-print Network

    Meskhidze, Nicholas

    October 2010 Abstract. Biomass burning (BB) in southern Africa is the largest emission source of CO and O3 southern Africa were found to exert a significant influence over the TAO and EA between 10 S­20 N to capture the tropospheric profile of CO in southern Africa near the main source region of the BB emissions

  4. Further Improved Differential Fault Analysis on Camellia by Exploring Fault Width and

    E-print Network

    1 Further Improved Differential Fault Analysis on Camellia by Exploring Fault Width and Depth Xin-jie Zhao, Tao Wang Abstract--In this paper, we present two further improved differential fault analysis/256 key hypotheses to 2 22.2 and 2 31.8 respectively. Index Terms--Differential fault analysis, Feistel

  5. Fast Password Recovery Attack: Application to Fanbao Liu1,2

    E-print Network

    Fast Password Recovery Attack: Application to APOP Fanbao Liu1,2 , Yi Liu2 , Tao Xie1 and Yumeng. China 2 School of Computer, Beijing University of Technology, 100124, Beijing, P. R. China liufanbao@gmail.com Abstract. In this paper, we propose a fast password recovery attack to APOP application in local which can

  6. Xian-Sheng Hua Microsoft Research Asia, China

    E-print Network

    Tomkins, Andrew

    contexts, and build models to predict which ads will most interest future users and maximize revenues Delft University of Technology, The Netherlands Online Multimedia Advertising: Techniques and Technologies #12;Online multimedia advertising : techniques and technologies / Xian-Sheng Hua, Tao Mei and Alan

  7. A Study on the Application of Laozi's Thoughts on Educational Leadership and Management

    ERIC Educational Resources Information Center

    Wen, Lian-shiung; Hwang, Kevin P.

    2008-01-01

    This paper attempts to apply historical methods to help understand the relationship between the philosophy espoused in the works of Laozi or Tao De Ching and educational leadership. The objective is to study the thought of Laozi regarding leadership, to identify ideas and solutions that can be applied in modern educational management, as well as…

  8. Improving Automation in Developer Testing: State of the Practice Department of Computer Science, North Carolina State University, Raleigh, NC 27695, USA

    E-print Network

    Young, R. Michael

    of techniques implemented in industrial developer testing tools to address challenges in improving automation. We provide in- sights to major industrial tools' key features in improving automation in developerImproving Automation in Developer Testing: State of the Practice Tao Xie Department of Computer

  9. An Improved Construction of Progression-Free Sets Michael Elkin

    E-print Network

    Elkin, Michael

    of constructing dense subsets S of {1, 2, . . ., n} that contain no three-term arithmetic progression arbitrarily long arithmetic progressions of prime numbers (see, e.g., Green and Tao [24]), and to otherAn Improved Construction of Progression-Free Sets Michael Elkin Abstract The problem

  10. numbers and SAT Oliver Kullmann

    E-print Network

    Martin, Ralph R.

    (diagonal form), created by the OKlibrary: c 2 parts, arithmetic progressions of size 3, and 9 prime numbers extensions The generic boolean translation On the history of the Green-Tao theorem Arithmetic progressions n prime numbers contain an arithmetic progression of length k. Trivially grt1(1) = 1 and grt1(2) = 2

  11. Lethbridge Number Theory and Combinatorics Seminar

    E-print Network

    Seldin, Jonathan P.

    contain a 3 term arithmetic progression. The previous methods of Helfgott and De Roton, and the speaker subprogression when A contains no arithmetic progressions. By iterating we show that for any constant B > 0)B , then A contains a three term arithmetic progression. By combining Green and Taos transference principle

  12. Seminaire BOURBAKI Mars 2012 64`eme annee, 2011-2012, no 1054

    E-print Network

    Wolf, Julia

    theorem from 2004, Green and Tao showed that there exist arbitrarily long arithmetic progressions). -- The primes contain arbitrarily long arithmetic progressions. Moreover, the same is true of any subset an infinite arithmetic progression. Suppose that P(j) = a + jd for some a, d N takes prime values for j = 0

  13. JDF: Detecting Duplicate Bug Reports in Jazz Yoonki Song1

    E-print Network

    Xie, Tao

    JDF: Detecting Duplicate Bug Reports in Jazz Yoonki Song1 Xiaoyin Wang2,3 Tao Xie1 Lu Zhang2 and users submit bug reports to a bug repository. These reports can help reveal defects and improve software qual- ity. As the number of bug reports in a bug repository increases, the number of the potential

  14. Interestingness Prediction by Robust Learning to Rank

    E-print Network

    Gong, Shaogang

    Interestingness Prediction by Robust Learning to Rank Yanwei Fu , Timothy M. Hospedales , Tao Xiang task as a unified robust learning to rank problem, tackling both the outlier detection the interesting- ness value of training data for learning a prediction model is challenging. To make

  15. A Multi-core High Performance Computing Framework for Distribution Power Flow

    E-print Network

    Franchetti, Franz

    A Multi-core High Performance Computing Framework for Distribution Power Flow Tao Cui and Franz developed a high performance parallel distribution power flow solver for Monte Carlo styled application. From computer architecture and programming point of view, we show that by applying various performance

  16. Recognition of Artificial 3D Landmarks from Depth and Color ---a first Prototype of Electronic Glasses for Blind People

    E-print Network

    Recognition of Artificial 3­D Landmarks from Depth and Color --- a first Prototype of Electronic Glasses for Blind People A. Luo a , X.­F. Zhang b , W. Tao c and H. Burkhardt b; a Mikroelektronik In this paper we present a robust method for the recog­ nition of 3D landmarks. Firstly the stereo and color

  17. Mining the Values in the Curriculum.

    ERIC Educational Resources Information Center

    Ryan, Kevin

    1993-01-01

    Schools must provide opportunities for students to discover what is most worth knowing, as they prepare to be citizens, good workers, good private individuals. Formal curriculum is one vehicle for teaching Tao (universal path to becoming a good person). Hidden curriculum can also convey profound teachings, if a spirit of fairness predominates,…

  18. To Help My People: The Evolution of a Paraprofessional.

    ERIC Educational Resources Information Center

    Archuleta, Carlos

    Half Pueblo and half white, a young man grew up in the Taos Pueblo, made contributions to his Indian people, and decided to work as a mental health professional. Having grown up learning the Indian ways, the young man accepted his heritage and pursued a college education in Social Work after working as a teacher's aide at the Pueblo Day School,…

  19. Cooperation control in Parallel SAT Solving: a Multi-armed Bandit Approach

    E-print Network

    Hamadi, Yousseff

    Microsoft Research 7 J J Thomson Avenue, Cambridge, UK youssefh@microsoft.com Said Jabbour CRIL-CNRS, Universit´e d'Artois Rue Jean Souvraz, Lens, France jabbour@cril.fr Mich`ele Sebag TAO, CNRS - INRIA - LRI

  20. Blood Impedance Characterization from Pulsatile Measurements School of Information Technology

    E-print Network

    Adler, Andy

    Blood Impedance Characterization from Pulsatile Measurements Tao Dai School of Information of blood excluding the contributions from surround- ing tissues, based on analysis of the pulsatile MHz. The finger is modeled as three parts: arterial blood, surrounding tissues and incremental in