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1

Thyroid-Associated Ophthalmopathy and Dermopathy  

Microsoft Academic Search

Graves’ ophthalmopathy [thyroid-associated ophthalmopathy (TAO)] and dermopathy [thyroid-associated dermopathy (TAD)] are\\u000a extrathyroidal manifestations of Graves’ disease, which should be viewed as a multisystem autoimmune disease involving thyrocytes\\u000a but also orbital and pretibial fibroblasts. Smoking is a risk factor for TAO, and cessation of smoking is useful in the primary,\\u000a secondary and tertiary prevention of TAO. The immunopathogenesis of TAO and

Wilmar M. Wiersinga

2

Increased Generation of Fibrocytes in Thyroid-Associated Ophthalmopathy  

PubMed Central

Context: The pathogenic basis for Graves’ disease (GD) continues to elude our understanding. Specifically why activating antibodies are generated against self-antigens remains uncertain as does the identity of the antigen(s) that provokes orbital involvement in GD, a process known as thyroid-associated ophthalmopathy (TAO). Objective: The aim of the study was to determine whether CD34+ fibrocytes are generated more frequently in GD, whether they infiltrate orbital connective tissues in TAO, and whether they express the thyrotropin receptor (TSHR). Design/Setting/Participants: Generation of fibrocytes from peripheral blood mononuclear cells was examined in samples from 70 patients with GD and 25 healthy control subjects. Fibrocytes were characterized by flow cytometry. Orbital tissues and fibroblast culture strains were examined for their presence. Main Outcome Measures: The frequency of CD34+ fibrocyte generation from peripheral blood cells, characterization of their phenotype, cytokine production, and their presence in affected orbital tissues were analyzed. Results: CD34+CXCR4+Col I+ fibrocytes expressing IGF-I receptor are far more frequently generated from cultured peripheral blood mononuclear cells of donors with GD compared with healthy subjects. They express TSHR at high levels and TSH induces fibrocytes to produce IL-6 and TNF-?. Numerous CD34+ fibrocytes were detected in orbital tissues in TAO but were absent in healthy orbits. Tissue-infiltrating fibrocytes express TSHR in situ and comprise a subpopulation of TAO-derived orbital fibroblasts. Conclusions: Our findings suggest that fibrocytes may participate in the pathogenesis of TAO because they express relevant autoantigens such as IGF-I receptor and functional TSHR and differentially accumulate in orbital tissue in TAO.

Douglas, Raymond S.; Afifiyan, Nikoo F.; Hwang, Catherine J.; Chong, Kelvin; Haider, Uzma; Richards, Patrick; Gianoukakis, Andrew G.; Smith, Terry J.

2010-01-01

3

Selenium supplementation in thyroid associated ophthalmopathy: an update  

PubMed Central

The therapeutic effect of selenium (Se) has already been proven in thyroid disease and thyroid associated ophthalmopathy (TAO). In spite of clear scientific proof of its benefits in TAO, there appears to be no clear agreement among the clinicians regarding its optimum dose, duration of the treatment, efficacy and safety to date. In this review, the author summarises the findings of 135 English language articles published on this subject over the past four decades from 1973 to 2013. The regulation and metabolism of thyroid hormones require a steady supply of Se and recent studies have revealed several possible mechanisms by which Se improves the severity of thyroid disease and TAO. These mechanisms include 1) inhibitory effect of HLA-DR molecule expression on thyrocytes; 2) profound reductions of thyroid stimulating hormone (TSH) receptor antibodies (TSHR-Ab) and TPO antibodies (TPO-Ab); 3) prevention of dysregulation of cell-mediated immunity and B cell function; 4) neutralising reactive oxygen species (ROS) and inhibition of redox control processes required for the activation, differentiation and action of lymphocytes, macrophages, neutrophils, natural killer cells involved in both acute and chronic orbital inflammation in TAO; 5) inhibition of expression of pro-inflammatory cytokines and 6) inhibition of prostaglandin and leukotriene synthesis. An increased oxidative stress has been observed in both acute and chronic phases of thyroid disease with raised tissue concentrations of ROS. The benefits of Se supplementation in individuals with TAO appear to be proportionate to the degree of systemic activity of the thyroid disease. The maximal benefit of Se supplementation is therefore seen in the subjects who are hyperthyroid. Restoration of euthyroidism is one of the main goals in the management of TAO and when anti-thyroid drugs are combined with Se, the patients with Graves' disease (GD) and autoimmune thyroiditis (AIT) achieved euthyroidism faster than those treated with anti-thyroid drugs alone. Se status of normal adult humans can vary widely and Se supplementation may confer benefit only if serum Se levels are insufficient. The author recommends that serum Se levels of patients with TAO to be assessed prior to and during Se supplementation at regular intervals to avoid potential iatrogenic chronic Se overdose.

Dharmasena, Aruna

2014-01-01

4

Pathogenesis of thyroid-associated ophthalmopathy: does autoimmunity against calsequestrin and collagen XIII play a role?  

PubMed Central

Thyroid-associated ophthalmopathy (TAO), or thyroid eye disease, is a complex inflammatory disorder of the eye that, as its name implies, is associated with thyroid disease. TAO can be divided into three subtypes: ocular myopathy, congestive myopathy and mixed congestive and myopathic ophthalmopathy. Although the precise pathophysiology of TAO remains unclear it is likely to reflect an autoimmune reaction involving sensitized T-cells and autoantibodies directed against a thyroid and orbital tissue shared antigen. One well studied candidate in this immune reaction is the thyroid-stimulating hormone receptor (TSH-r), expressed in the orbital fibroblast and pre adipocyte. In our studies of TAO, we have investigated the nature and significance of antibodies targeting other eye muscle and orbital connective tissue (OCT) antigens. Our findings suggest that autoimmunity against the eye muscle antigen calsequestrin and the OCT antigen collagen XIII plays a role in the pathogenesis of TAO. We propose that ocular myopathy and chronic eyelid retraction are due to autoimmunity against skeletal muscle calsequestrin in the extraocular and eyelid muscles, respectively. This may be initiated in the thyroid where calsequestrin expression is upregulated, possibly due to a stimulatory effect of TSH-r antibodies. We also propose that congestive ophthalmopathy results from a reaction against the TSH-r or collagen XIII in orbital fibroblast cell membranes. Further insight into the role of eye muscle and OCT antigens in the pathogenesis of TAO may allow for the development of new therapies to treat the eye disorder and reduce patient morbidity.

Lahooti, Hooshang; Parmar, Kishan R; Wall, Jack R

2010-01-01

5

Are Ethnicity, Social Grade, and Social Deprivation Associated With Severity of Thyroid-Associated Ophthalmopathy?  

PubMed Central

Purpose: Previous studies have extensively investigated the pathophysiology, genetics, and lifestyle risk factors of thyroid-associated ophthalmopathy (TAO). The aim of this study was to investigate the independent contribution of ethnic origin, social grade, and level of social deprivation to TAO severity in a large, multiethnic, and urban population. Methods: Retrospective case note review of all TAO patients seen at Birmingham and Midland Eye Centre, United Kingdom over a 14-year period. Ethnicity (White, Asian, or Black) was recorded, and residence postcode was used to determine social grade (National Readership Survey classification) and level of social deprivation (Index of Multiple Deprivation 2007). TAO severity was defined by European Group on Graves’ Orbitopathy criteria. Moderate-to-severe: necessity for TAO treatment with oral or intravenous steroid, long-term immunosuppressants, or orbital radiotherapy. Sight-threatening: presence of dysthyroid optic neuropathy (DON) or need for urgent orbital decompression surgery. Multivariable logistic regression was performed to measure the independent influence of ethnicity, social grade, and social deprivation on indicators of severe TAO. Results: Lower social grade was significantly associated with increased odds ratio (OR) of TAO patients having severe TAO, including treatment with oral (OR: 2.3 (95% CI 1.1–5.1) p = 0.03) and intravenous steroid (OR: 2.6 (95% CI 1.0–7.0) p = 0.04) and DON (OR: 4.0 (95% CI 1.2–12.7) p = 0.02), compared with those of highest social grade. Similar results were observed for social deprivation. Ethnicity had no independent association with any measure of TAO severity. Conclusions: In this cohort, lower social grade and higher social deprivation, but not ethnicity, had independent, statistically significant association with more severe TAO.

Huntbach, Julie A.; Durrani, Omar M.

2014-01-01

6

Contrast Sensitivity of Thyroid Associated Ophthalmopathy Patients without Obvious Optic Neuropathy  

PubMed Central

Purpose. To compare the contrast sensitivity levels of thyroid associated ophthalmopathy (TAO) patients without obvious optic neuropathy with those of healthy people. Methods. Forty eyes of 20 TAO patients without dysthyroid optic neuropathy and 40 eyes of 20 healthy subjects were evaluated in this prospective case-controlled study. The contrast sensitivity functions (CSFs) of all subjects were measured by the functional acuity contrast test (FACT) in five frequencies which were 1,5 cpd (A), 3 cpd (B), 6 cpd (C), 12 cpd (D), and 18 cpd (E). Results were compared for both groups, and a correlation of CSF with Hertel and clinical activity scores was assessed. Results. There was no statistically significant difference between TAO patients and control groups for age and sex. TAO patients had lower levels than the control group in all the frequencies of CSFs (P < 0.05) and the difference in contrast sensitivity functions between the groups seems to be more significant in higher frequencies (B, C, D, and E) (P < 0.001). Conclusions. TAO patients without DON can have contrast sensitivity loss and this would probably imply subtle optic nerve dysfunction in early disease phase.

Beden, Umit; Kaya, Sumeyra; Yeter, Volkan; Erkan, Dilek

2013-01-01

7

Clinical features of thyroid-associated ophthalmopathy in clinically euthyroid Korean patients  

PubMed Central

Aim To compare clinical characteristics and thyroid-stimulating hormone receptor antibodies (TRAbs) in thyroid-associated ophthalmopathy (TAO) in euthyroid Korean patients with those in hyperthyroid patients. Methods Clinical activity scores (CASs), modified NOSPECS scores, exophthalmometry values, prevalence of optic neuropathy, restrictive myopathy and lid retraction, and the positivity and levels of TRAb (thyrotropin-binding inhibitor immunoglobulin (TBII) and thyroid-stimulating immunoglobulin (TSI)) were compared in 24 euthyroid (group A) and 139 clinical/subclinical hyperthyroid TAO patients (group B). Results Group A presented more clinically unilateral involvement than group B (79.2% vs 27.3%, P<0.001), less active (CAS 1.50 vs 2.26, P=0.014) and less severe clinical course (NOSPECS 3.38 vs 4.13, P=0.037). Lid retraction was more prevalent in group A than group B (91.7% vs 66.2%, P=0.014). Prevalence of optic neuropathy and restrictive myopathy, and the mean value of exophthalmometry were not different. Mean TBII levels were lower (7.20?IU/l) in group A than in group B (44.58?IU/l, P<0.001). A similar difference was found in the TSI bioassay (201.40% vs 425.19%, P=0.001). The positive rate of TBII in group A (34.8%) was significantly lower than in group B (90.8%, P<0.001). The positive rate of TSI was high in both group A (83.3%) and B (91.7%), with no significant difference (P=0.337). Conclusions Patients with euthyroid TAO showed a less active and severe clinical course, more unilateral involvement, and lower levels of TRAb than those in patients with hyperthyroid TAO. These distinct clinical and biochemical characteristics might be useful in assessment of euthyroid TAO, and the TSI might be more sensitive for diagnosing these patients.

Jang, S Y; Lee, S Y; Lee, E J; Yoon, J S

2012-01-01

8

Increased Expression of TSH Receptor by Fibrocytes in Thyroid-Associated Ophthalmopathy Leads to Chemokine Production  

PubMed Central

Context: The molecular basis for anatomically dispersed clinical manifestations in Graves' disease (GD) eludes our understanding. Bone marrow-derived, pluripotent fibrocytes represent a subset of peripheral blood mononuclear cells and infiltrate the orbital and thyroid tissues in GD. These cells may be involved in the pathogenesis of thyroid-associated ophthalmopathy (TAO). Objective: The objective of the study was to quantify fibrocyte display of functional cell surface TSH receptor (TSHR), identify the profile of chemokines they express after TSHR activation, and determine whether circulating TSHR+ peripheral blood fibrocytes are more frequent in situ in patients with TAO. Design/Setting/Participants: Using a newly developed technique, fibrocytes were directly identified in peripheral blood from 31 patients with TAO and 19 healthy subjects receiving care at a multidisciplinary academic center. Main Outcome Measures: The frequency in situ of fibrocytes (collagen 1+, CD45+, CD34+, CD14+, CD86+ peripheral blood mononuclear cells) was assessed by multiparameter flow cytometry and correlated to clinical disease activity and smoking status. Levels of TSHR-displaying fibrocytes and their response to TSH and TSHR-activating antibody, M22, were measured by flow cytometry, Luminex, and real-time PCR. Results: The levels of TSHR expression by fibrocytes are substantially higher than those found in orbital fibroblasts. Moreover, the frequency of TSHR+ fibrocytes in patients with TAO was greater than that in healthy subjects in situ. Their abundance is not influenced by disease activity or smoking history. These cells produce high levels of several cytokines and chemokines including IL-8, regulated upon activation, normal T cell expressed and secreted, and monocyte chemoattractant protein-1 when treated with TSH or M22. TSH induces IL-8 production at the pretranslational level. This induced cytokine can be detected in intact fibrocytes ex vivo. Conclusions: Frequency of circulating TSHR+ fibrocytes is markedly increased in patients with TAO, and they express proinflammatory chemokines in response to TSH. Because they infiltrate both orbit and thyroid in GD, they may represent the link between systemic immunoreactivity and organ-specific autoimmunity.

Gillespie, Erin F.; Papageorgiou, Konstantinos I.; Fernando, Roshini; Raychaudhuri, Nupur; Cockerham, Kimberly P.; Charara, Laya K.; Goncalves, Allan C. P.; Zhao, Shuang-Xia; Ginter, Anna; Lu, Ying; Smith, Terry J.

2012-01-01

9

Acetazolamide and Thyroid-Associated Ophthalmopathy; a Preliminary Tested Hypothesis in a TertiaryReferral Center.  

PubMed

This study evaluated the effect of acetazolamide on thyroid-associated ophthalmopathy (TAO). Patients with a VISA classification index equal to or more than four were enrolled in the study and were randomly assigned into two groups. In both groups, treatment was initiated using prednisolone. Patients in the case group received acetazolamide tablets 250 mg daily in addition to prednisolone. Three months later, the VISA inflammatory score of patients in both groups were determined. Subsequent to intervention with acetazolamide, the VISA inflammatory score of patients in the case group were reduced as follows; orbital pain (57.1% versus 41.7%, P=0.736), eyelid edema (42.8% versus 27.1%, P=0.67), chemosis (53.3% versus 33%, P=0.31), injection of the eyelids (60% versus 41.6%, P=0.342), and conjunctival injection (50% versus 46.13%, P=0.73). However, these reductions were not statistically significant when compared with those observed in the control group (P=0.246). In conclusion, the effect of acetazolamide on all the parameters of the VISA inflammatory score was examined independently. All patients in the case group revealed a reduction in VISA inflammatory score following intervention. However, these reductions were not statistically significant. Further studies with large sample sizes are required. PMID:24822231

Khataminia, Gholamreza; Ostadian, Farshad; Noroozzadeh, Mohammad; Latifi, Mahmoud; Khataminia, Masoud

2013-01-01

10

Acetazolamide and Thyroid-Associated Ophthalmopathy; a Preliminary Tested Hypothesis in a TertiaryReferral Center  

PubMed Central

This study evaluated the effect of acetazolamide on thyroid-associated ophthalmopathy (TAO). Patients with a VISA classification index equal to or more than four were enrolled in the study and were randomly assigned into two groups. In both groups, treatment was initiated using prednisolone. Patients in the case group received acetazolamide tablets 250 mg daily in addition to prednisolone. Three months later, the VISA inflammatory score of patients in both groups were determined. Subsequent to intervention with acetazolamide, the VISA inflammatory score of patients in the case group were reduced as follows; orbital pain (57.1% versus 41.7%, P=0.736), eyelid edema (42.8% versus 27.1%, P=0.67), chemosis (53.3% versus 33%, P=0.31), injection of the eyelids (60% versus 41.6%, P=0.342), and conjunctival injection (50% versus 46.13%, P=0.73). However, these reductions were not statistically significant when compared with those observed in the control group (P=0.246). In conclusion, the effect of acetazolamide on all the parameters of the VISA inflammatory score was examined independently. All patients in the case group revealed a reduction in VISA inflammatory score following intervention. However, these reductions were not statistically significant. Further studies with large sample sizes are required.

Khataminia, Gholamreza; Ostadian, Farshad; Noroozzadeh, Mohammad; Latifi, Mahmoud; Khataminia, Masoud

2013-01-01

11

Targeted biological therapies for Graves' disease and thyroid associated ophthalmopathy. Focus on B cell depletion with Rituximab  

PubMed Central

Summary Based on experience from the treatment of other autoimmune diseases and due to inherent shortcomings of the existing therapy options for Graves’ disease (GD) and thyroid associated ophthalmopathy (TAO), rituximab was recently introduced as a novel therapy option. Here we summarize the rationale for using rituximab; give an overview of the possible mechanisms of action; and give an account of its effects and side effects when used in GD and TAO. Low quality evidence, originating from few and methodologically inhomogeneous studies, suggests that rituximab may prolong remission for hyperthyroidism over that seen with antithyroid drugs, at least in mild GD. Furthermore, in TAO patients, unresponsive to conventional immunosuppressive therapy, rituximab seems efficacious. Awaiting large-scale randomized studies, rituximab, due to limited experience and high cost, should be considered experimental and reserved for patients who do not respond favourably to conventional therapy. Rituximab is the first in a series of new and emerging treatments addressing specific therapeutic targets, such as, which will hopefully lead to improved and better tailored individualized therapy for GD and especially TAO.

Hegedus, Laszlo; Smith, Terry J.; Douglas, Raymond S.; Nielsen, Ciaus H.

2013-01-01

12

Interleukin-6 Production in CD40-Engaged Fibrocytes in Thyroid-Associated Ophthalmopathy: Involvement of Akt and NF-?B  

PubMed Central

Purpose. CD40–CD40 ligand (CD40L) interactions appear to play pathogenic roles in autoimmune disease. Here we quantify CD40 expression on fibrocytes, circulating, and bone marrow–derived progenitor cells. The functional consequences of CD40 ligation are determined since these may promote tissue remodeling linked with thyroid-associated ophthalmopathy (TAO). Methods. CD40 levels on cultivated fibrocytes and orbital fibroblasts (GOFB) from patients with Graves' disease (GD), as well as fibrocyte abundance, were determined by flow cytometry. CD40 mRNA expression was evaluated by real-time PCR, whereas response to CD40 ligation was measured by Luminex and RT-PCR. Protein kinase B (Akt) and nuclear factor (NF)–kappa B (NF-?B) signaling were determined by Western blot and immunofluorescence. Results. Basal CD40 expression on fibrocytes is greater than that on GOFB. IFN-? upregulates CD40 in both cell types and its actions are mediated at the pretranslational level. Fibrocytes produce high levels of cytokines, including interleukin-6 (IL-6), TNF-?, IL-8, MCP-1, and RANTES (Regulated on Activation, Normal T Cell Expressed and Secreted) in response to CD40L. IL-6 induction results from an increase in steady state IL-6 mRNA, and is mediated through Akt and NF-?B activation. Circulating CD40+CD45+Col1+ fibrocytes are far more frequent in vivo in donors with TAO compared with healthy subjects. Conclusions. Particularly high levels of functional CD40 are displayed by fibrocytes. CD40L-provoked signaling results in the production of several cytokines. Among these, IL-6 expression is mediated through Akt and NF-?B pathways. The frequency of circulating CD40+ fibrocytes is markedly increased in patients with TAO, suggesting that this receptor might represent a therapeutic target for TAO.

Gillespie, Erin F.; Raychaudhuri, Nupur; Papageorgiou, Konstantinos I.; Atkins, Stephen J.; Lu, Ying; Charara, Laya K.; Mester, Tunde; Smith, Terry J.; Douglas, Raymond S.

2012-01-01

13

Benzylideneacetophenone derivatives attenuate IFN-?-induced IP-10/CXCL10 production in orbital fibroblasts of patients with thyroid-associated ophthalmopathy through STAT-1 inhibition.  

PubMed

The aim of the present study was to identify a new candidate anti-inflammatory compound for use in the active stage of thyroid-associated ophthalmopathy (TAO). Benzylideneacetophenone compound JC3 [(2E)-3-(4-hydroxy-3-methoxyphenyl)phenylpro-2-en-l-one] was synthesized based on a structural modification of yakuchinone B, a constituent of the seeds of Alpinia oxyphylla, which belongs to the ginger family (Zingiberaceae), has been widely used in folk medicine as an anti-inflammatory phytochemical. Orbital fibroblasts were primarily cultured from patients with TAO, and the potential of JC3 to suppress the interferon (IFN)-?-induced protein (IP)-10/CXCL10 production in these cells was determined. IFN-? strongly increased the level of IP-10/CXCL10 in orbital fibroblasts from patients with TAO. JC3 exerted a significant inhibitory effect on the IFN-?-induced increase in IP-10/CXCL10 in a dose-dependent manner; its potency was greater than that of an identical concentration of yakuchinone B with no toxicity to cells at the concentration range used. Moreover, the constructed dimer and trimer polystructures of JC3, showed greater potency than JC3 in suppressing the IFN-?-induced production of IP-10/CXCL10. JC3 significantly attenuated the IP-10/CXCL10 mRNA expression induced by IFN-?, and a gel-shift assay showed that JC3 suppressed IFN-?-induced DNA binding of signal transducer and activator of transcription-1 (STAT-1) in TAO orbital fibroblasts. Our results provide initial evidence that the JC3 compound reduces the levels of IP-10/CXCL10 protein and mRNA induced by IFN-? in orbital fibroblasts of TAO patients. Therefore, JC3 might be considered as a future candidate for therapeutic application in TAO that exerts its effects by modulating the pathogenic mechanisms in orbital fibroblasts. PMID:24924312

Lee, Sung-Hee; Lim, Seul Ye; Choi, Ji Ha; Jung, Jae-Chul; Oh, Seikwan; Kook, Koung Hoon; Choi, Youn-Hee

2014-01-01

14

Benzylideneacetophenone derivatives attenuate IFN-?-induced IP-10/CXCL10 production in orbital fibroblasts of patients with thyroid-associated ophthalmopathy through STAT-1 inhibition  

PubMed Central

The aim of the present study was to identify a new candidate anti-inflammatory compound for use in the active stage of thyroid-associated ophthalmopathy (TAO). Benzylideneacetophenone compound JC3 [(2E)-3-(4-hydroxy-3-methoxyphenyl)phenylpro-2-en-l-one] was synthesized based on a structural modification of yakuchinone B, a constituent of the seeds of Alpinia oxyphylla, which belongs to the ginger family (Zingiberaceae), has been widely used in folk medicine as an anti-inflammatory phytochemical. Orbital fibroblasts were primarily cultured from patients with TAO, and the potential of JC3 to suppress the interferon (IFN)-?-induced protein (IP)-10/CXCL10 production in these cells was determined. IFN-? strongly increased the level of IP-10/CXCL10 in orbital fibroblasts from patients with TAO. JC3 exerted a significant inhibitory effect on the IFN-?-induced increase in IP-10/CXCL10 in a dose-dependent manner; its potency was greater than that of an identical concentration of yakuchinone B with no toxicity to cells at the concentration range used. Moreover, the constructed dimer and trimer polystructures of JC3, showed greater potency than JC3 in suppressing the IFN-?-induced production of IP-10/CXCL10. JC3 significantly attenuated the IP-10/CXCL10 mRNA expression induced by IFN-?, and a gel-shift assay showed that JC3 suppressed IFN-?-induced DNA binding of signal transducer and activator of transcription-1 (STAT-1) in TAO orbital fibroblasts. Our results provide initial evidence that the JC3 compound reduces the levels of IP-10/CXCL10 protein and mRNA induced by IFN-? in orbital fibroblasts of TAO patients. Therefore, JC3 might be considered as a future candidate for therapeutic application in TAO that exerts its effects by modulating the pathogenic mechanisms in orbital fibroblasts.

Lee, Sung-Hee; Lim, Seul Ye; Choi, Ji Ha; Jung, Jae-Chul; Oh, Seikwan; Kook, Koung Hoon; Choi, Youn-Hee

2014-01-01

15

Semiautomatic regional segmentation to measure orbital fat volumes in thyroid-associated ophthalmopathy. A validation study.  

PubMed

This study was designed to validate a novel semi-automated segmentation method to measure regional intra-orbital fat tissue volume in Graves' ophthalmopathy. Twenty-four orbits from 12 patients with Graves' ophthalmopathy, 24 orbits from 12 controls, ten orbits from five MRI study simulations and two orbits from a digital model were used. Following manual region of interest definition of the orbital volumes performed by two operators with different levels of expertise, an automated procedure calculated intra-orbital fat tissue volumes (global and regional, with automated definition of four quadrants). In patients with Graves' disease, clinical activity score and degree of exophthalmos were measured and correlated with intra-orbital fat volumes. Operator performance was evaluated and statistical analysis of the measurements was performed. Accurate intra-orbital fat volume measurements were obtained with coefficients of variation below 5%. The mean operator difference in total fat volume measurements was 0.56%. Patients had significantly higher intra-orbital fat volumes than controls (p<0.001 using Student's t test). Fat volumes and clinical score were significantly correlated (p<0.001). The semi-automated method described here can provide accurate, reproducible intra-orbital fat measurements with low inter-operator variation and good correlation with clinical data. PMID:24007725

Comerci, M; Elefante, A; Strianese, D; Senese, R; Bonavolontà, P; Alfano, B; Bonavolontà, B; Brunetti, A

2013-08-01

16

Graves' Ophthalmopathy  

PubMed Central

Graves’ ophthalmopathy, also called Graves’ orbitopathy, is a potentially sight-threatening ocular disease that has puzzled physicians and scientists for nearly two centuries.1–3 Generally occurring in patients with hyperthyroidism or a history of hyperthyroidism due to Graves’ disease, Graves’ ophthalmopathy is also known as thyroid-associated ophthalmopathy or thyroid eye disease, because it sometimes occurs in patients with euthyroid or hypothyroid chronic autoimmune thyroiditis. The condition has an annual adjusted incidence rate of 16 women and 3 men per 100,000 population.4 This review explores the perplexing relationship between Graves’ ophthalmopathy, hyperthyroidism, and thyroid dermopathy, the associated skin condition. I examine clinical features, histologic findings, and laboratory studies, with an emphasis on mechanisms that could be targeted in the development of new treatments for this debilitating disease.

Bahn, Rebecca S.

2014-01-01

17

Cloning and Characterization of the Novel Thyroid and Eye Muscle Shared Protein G2s: Autoantibodies against G2s Are Closely Associated with Ophthalmopathy in Patients with Graves' Hyperthyroidism  

Microsoft Academic Search

Serum autoantibodies against eye muscle antigens are closely linked with thyroid-associated ophthalmopathy (TAO), although their significance is unclear. The two antigens that are most often recognized are eye muscle membrane proteins with molecular masses of 55 and 64 kDa, as determined from immunoblotting with crude human or porcine eye muscle membranes. We cloned a fragment of the 55-kDa protein by

KAZUAKI GUNJI; ANNAMARIA DE BELLIS; AUDREY WU LI; MASAYO YAMADA; SUMIHISA KUBOTA; BRIAN ACKRELL; SYLVIA WENGROWICZ; ANTONIO BELLASTELLA; ANTONIO BIZZARRO; ANTONIO SINISI; JACK R. WALL

18

Thyroid associated orbitopathy.  

PubMed

Thyroid-associated orbitopathy (TAO) is a self-limiting auto-immune condition usually associated with Grave's disease. It is characterised by ocular pain, eyelid swelling, chemosis, proptosis and keratopathy. As the mechanism for ophthamoplegia and optic neuropathy is the orbital swelling leading to mechanical restriction of ocular muscles and compression of optic nerve, one expects proptosis rather than ptosis in TAO. We describe a case of a young adult woman who presented with acute onset restriction of movement along with partial ptosis and severe diminution of vision in left eye. The MRI of orbit revealed significant swelling of recti along with signal alteration consistent with TAO. The radio-isotope thyroid scan revealed thyroiditis, and thyroid peroxidase (TPO) antibody was significantly high; hence, the diagnosis of Hashimoto thyroiditis was considered. A course of intravenous methylprednisolone followed by oral steroid was administered, which produced marked improvement in vision and extraocular movement. PMID:23737589

Verma, Rajesh; Gupta, Mani; Mehta, Vinod Kumar

2013-01-01

19

Graves' ophthalmopathy.  

PubMed Central

Ophthalmopathy develops in about 30% of patients who have Graves' disease. The pathogenesis, like that of the hyperthyroidism, is probably autoimmune in nature. The eye manifestations are diverse and include lid lag, soft tissue swelling, proptosis, corneal damage, diplopia, and optic neuropathy. The natural history is benign in 90% of patients, with gradual improvement over time. Therapeutic options include corticosteroid therapy, radiation, and surgical treatment. The last is usually the therapy of choice for severe or disfiguring ophthalmopathy.

Barrie, W E

1993-01-01

20

Graves' ophthalmopathy.  

PubMed Central

Graves' ophthalmopathy usually occurs in association with hyperthyroidism. Its occasional occurrence in the absence of thyroid disease suggests, however, that it may be a separate autoimmune disorder. While the evidence supporting an autoimmune pathogenesis is considerable for the ophthalmopathy, it is not so impressive as that for Graves' hyperthyroidism: orbital antibodies have not been convincingly demonstrated and autoantigens have not been identified. On the other hand, in patients with Graves' ophthalmopathy the orbital tissues and eye muscle membranes are infiltrated with lymphoid cells and show evidence of cell-mediated immune reactions. Although there is some evidence that binding of thyroid stimulating hormone fragments and thyroglobulin-antithyroglobulin immune complexes to eye muscle membranes may be important in the pathogenesis of the ophthalmopathy, this needs to be confirmed. The mechanism for the association of hyperthyroidism and ophthalmopathy is unknown, but the association likely reflects an influence of thyroid hormones on the immune system. In view of the autoimmune pathogenesis the logical treatment of Graves' ophthalmopathy appears to be immunosuppression.

Wall, J R; Henderson, J; Strakosch, C R; Joyner, D M

1981-01-01

21

American Thyroid Association  

MedlinePLUS

... the ATA Media Corporate Information Search for: American Thyroid Association Public and Patients Physicians and Scientists Education ... Abstract Submissions ATA 2014 Call for Abstract Submissions THYROID June 2014 Now Available Online THYROID June 2014 ...

22

Severe thyroid-associated orbitopathy in Hashimoto's thyroiditis. Report of 2 cases.  

PubMed

Thyroid-associated orbitopathy (TAO) is characterized by immune-mediated inflammation of the extraocular muscles surrounding orbital connective tissue and adipose tissue. Severe orbitopathy related to autoimmune thyroid disease often occurs in patients with Grave's disease, but it is rare in patients with Hashimoto's thyroiditis. The pathogenesis of TAO is unclear. Several studies have noted a strong correlation between the levels of antibodies to thyrotropin receptor antibody (TRAb) and TAO in Graves' disease. Mild upper eyelid retraction has been reported to be common in Hashimoto's thyroiditis patients, however severe orbitopathy is rare. We report two cases of severe TAO in patients with Hashimoto's thyroiditis who required systemic glucocorticoid therapy and orbital irradiation to treat the TAO. The activity of the TAO was high in both patients, because their clinical activity scores (CAS) for the orbitopathy were high, and magnetic resonance imaging (MRI) showed enlargement of the extraocular muscles and an increase in T2 signal intensity and prolonged T2 relaxation time which indicate an active stage of inflammation. We tested the presence of TRAb by three different assays and were negative in both patients. Since the eye muscle damage cannot be due to TSH receptor antibodies, other pathogenetic mechanisms may be responsible for the orbitopathy in patients with Hashimoto's thyroiditis. PMID:21427503

Yoshihara, Ai; Yoshimura Noh, Jaeduk; Nakachi, Ayako; Ohye, Hidemi; Sato, Shiori; Sekiya, Kenichi; Kosuga, Yuka; Suzuki, Miho; Matsumoto, Masako; Kunii, Yo; Watanabe, Natsuko; Mukasa, Koji; Inoue, Yoichi; Ito, Kunihiko; Ito, Koichi

2011-01-01

23

Image fusion analysis of 99m Tc-HYNIC-octreotide scintigraphy and CT\\/MRI in patients with thyroid-associated orbitopathy: the importance of the lacrimal gland  

Microsoft Academic Search

The aim of this study was to describe the anatomical structures that show uptake of the somatostatin analogue octreotide in patients with thyroid-associated orbitopathy (TAO). The study population comprised a series of 20 TAO patients attending the out-patient thyroid clinic and 12 patients presenting head or neck tumours. Scintigraphy was carried out with our newly developed tracer, technetium-99m labelled EDDA-HYNIC-TOC

Hartmann Kainz; Reto Bale; Eveline Donnemiller; Michael Gabriel; Peter Kovacs; Clemens Decristoforo; Roy Moncayo

2003-01-01

24

Significance of serum antibodies reactive with flavoprotein subunit of succinate dehydrogenase in thyroid associated orbitopathy  

PubMed Central

AIMS—Thyroid associated orbitopathy (TAO) is an autoimmune disorder of extraocular muscles and orbital connective tissue. Identification of the principal target antigens would help the understanding of the pathogenesis of the disease and possibly lead to the development of specific therapies in the future. The purpose of this study was to measure serum antibodies against the flavoprotein subunit of succinate dehydrogenase in patients with TAO and correlate their presence with factors of TAO.?METHODS—Sera of patients with active TAO of 6 months' duration or less were tested for antibodies against the flavoprotein subunit of succinate dehydrogenase. Clinical data were obtained by retrospective review of patients' charts. Enzyme linked immunosorbent assay was used to test sera for serum antibodies against purified succinate dehydrogenase.?RESULTS—38 patients with TAO and 32 healthy age and sex matched controls were included in the study. Anti-flavoprotein antibodies were detected in 24 out of 38 patients with TAO (63.16%) and in five out of 32 healthy controls (15.63%) (p<0.01). Neither age, sex, duration of thyroid disease, thyroid status, treatment of thyroid disease, smoking history, duration of orbitopathy, activity of orbitopathy, nor the presence of lid retraction were significantly associated with the presence of serum anti-flavoprotein antibodies (p>0.05). However, the total number of rectus muscles affected in both eyes of the patients was significantly correlated with the finding of a positive antibody test (p<0.05).?CONCLUSIONS—Serum antibodies reactive with the flavoprotein subunit of succinate dehydrogenase are associated with extraocular muscle involvement in active TAO of recent onset.??

Hosal, B.; Swanson, J.; Thompson, C.; Kubota, S.; Gunji, K.; Kennerdell, J.; Wall, J.

1999-01-01

25

TAO users manual.  

SciTech Connect

The Toolkit for Advanced Optimization (TAO) focuses on the design and implementation of component-based optimization software for the solution of large-scale optimization applications on high-performance architectures. Their approach is motivated by the scattered support for parallel computations and lack of reuse of linear algebra software in currently available optimization software. The TAO design allows the reuse of toolkits that provide lower-level support (parallel sparse matrix data structures, preconditioners, solvers), and thus they are able to build on top of these toolkits instead of having to redevelop code. The advantages in terms of efficiency and development time are significant. The TAO design philosophy uses object-oriented techniques of data and state encapsulation, abstract classes, and limited inheritance to create a flexible optimization toolkit. This chapter provides a short introduction to the design philosophy by describing the objectives in TAO and the importance of this design. Since a major concern in the TAO project is the performance and scalability of optimization algorithms on large problems, they also present some performance results.

Benson, S.; McInnes, L. C.; More, J. J.; Sarich, J.

2003-12-02

26

Th1/Th2 cytokines in patients with Graves' disease with or without ophthalmopathy.  

PubMed

About 25-50% of Graves' disease (GD) patients develop thyroid eye diseases, which is associated with inflammatory process and abnormalities in the levels of several cytokines in orbital tissues in GD. The aim of this study was to determine the Th1 and Th2 serum cytokines in patients with GD with or without ophthalmopathy. Serum levels of cytokines and autoantibodies including Interferon-gamma (IFN-?), Interleukin-2 (IL-2), Interleukin-4 (IL-4), Interleukin-10 (IL-10), TSH receptor autoantibody (TRAb), thyroid peroxidase antibody (TPOAb) and thyroglobulin antibody(TgAb) were measured by enzyme linked immunosorbent assay(ELISA) in 34 patients with GD and in 33 normal controls. Patients were also divided in two subgroups: 18 cases with ophthalmopathy and 16 cases without ophthalmopathy. Cytokine and antibody responses were analyzed in both groups. Compared with control subjects, patients with GD showed elevated levels of IL-2 and IL-10. IFN-? levels were lower in patients in comparison to the controls. No significant differences were found between patients and controls regarding the IL-4. There was no statistically significant difference in cytokine levels between those with or without ophthalmopathy. Quantitative-cytokine analysis demonstrated that a combination of Th1 and Th2 cytokines may contribute to the pathogenesis of GD. These results also indicate that IL-10, but not IL-4, is related to the moderate and severe forms of thyroid associated ophthalmophathy. PMID:23754356

Esfahanian, Fatemeh; Naimi, Effat; Doroodgar, Farideh; Jadali, Zohre

2013-06-01

27

[Radiotherapy for Graves' ophthalmopathy].  

PubMed

Graves' ophthalmopathy (GO) is the most frequent extrathyroidal manifestation of Graves' disease, an autoimmune disorder of the thyroid, whereas the precise pathogenesis still remains unclear. In Hashimoto's thyroiditis the occurrence of proptosis is an extremely rare event. The therapy for middle and severe courses of GO shows in partly disappointing results, although several therapy modalities are possible (glucocorticoid therapy, radiotherapy, antithyroid drug treatment, surgery). All these therapies lead in only 40 - 70 % to an improvement of the pathogenic symptoms. An intensive interdisciplinary cooperation is necessary to satisfy the requirements for the treatment of Graves' ophthalmopathy. As a consequence of the very different results of the few of clinical studies that were accomplished with reference to this topic, treatment by radiotherapy in the management of the disease is presently controversially discussed. In the German-speaking countries the radiotherapy is, however, firmly established as a therapy option in the treatment of the moderate disease classes (class 2-5 according to NO SPECS), especially if diplopia is present. This article describes the sequences, dosages and fractionation schemes as well as the risks and side effects of the radiotherapy. Altogether, radiotherapy is assessed as an effective and sure method. The administration of glucocorticoids can take place before the beginning of or during the radiotherapy. For the success of treatment the correct selection of patients who may possibly profit from a radiotherapy is absolutely essential. By realising that GO proceeds normally over a period of 2-5 years, which is followed by a period of fibrotic alteration, the application of the radiotherapy in the early, active phase is indispensable. A precise explanation for the effects of radiotherapy in treatment of the GO does not exist at present. The determination of the most effective irradiation doses was made from retrospectively evaluated collectives. Recently the results of a national survey of all German RT departments were published, initiated by the working group of the DEGRO (German Society of Radiooncology). In the most of the German radiooncology departments irradiation with 8 to 10 x 1.8-2.0 Gy 5 x weekly to 16 or 20 Gy is standard. Two recently published prospective German studies pointed out the equivalence of the effectiveness of a short therapy in low dose ranges up to 2.4 Gy as well as of a low proportioned irradiation during a longer period in relation to a standard therapy with 20 Gy. That is why at the moment it is not possible to give a definite recommendation with reference to dosages or the fractionation schemes. In 2003 the first European group (European Group on Graves ' Orbitopathy Experience -- EUGOGO) was founded for pursuing investigations of GO in multi-centric studies, mainly to improve therapy results. PMID:15562354

Kuhnt, T; Müller, A C; Janich, M; Gerlach, R; Hädecke, J; Duncker, G I W; Dunst, J

2004-11-01

28

75 FR 81437 - Amendment of Class E Airspace; Taos, NM  

Federal Register 2010, 2011, 2012, 2013

...amends Class E airspace for Taos, NM. Decommissioning of the Ski non-directional beacon (NDB) at Taos Regional Airport, Taos...Class E airspace for the Taos, NM area. Decommissioning of the Ski NDB and cancellation of the NDB approach at Taos Regional...

2010-12-28

29

Ophthalmopathy in childhood Graves' disease  

PubMed Central

Aims: To study the ocular manifestations and their severity in children with Graves' disease. Methods: All patients with Graves' disease having regular follow up in a paediatric endocrine clinic were recruited for the study. A comprehensive ophthalmic assessment including ocular motility, exophthalmometry, intraocular pressure (IOP), slit lamp, and fundus examinations was performed. Results: 83 patients (72 female, 11 male) aged 16 years or below were examined. All are Chinese. Ocular symptoms occurred in 12 patients. Ocular signs of ophthalmopathy were documented in 52 patients (62.7%). Most of them presented with eyelid abnormalities such as lid oedema, lid lag, and lagophthalmos, whereas lower lid retraction was the commonest clinical sign noted (38.6%). Diffuse conjunctival injection was found in four patients (4.8%). 10 patients (12.0%) had mild proptosis of less than 3 mm. Only one patient (1.2%) had limited extraocular motility in extreme gaze. Punctate epithelial corneal erosions were reported in 11 patients (13.3%). Conclusions: This is the largest series on the ocular complications of childhood Graves' disease in the literature. Although 52 patients (62.7%) were identified with positive ocular changes, none of them had visual threatening complications or debilitating myopathy.

Chan, W; Wong, G W K; Fan, D S P; Cheng, A C K; Lam, D S C; Ng, J S K

2002-01-01

30

TAOS Project: Searching for Variable Stars in the Selected TAOS Fields and Optical Followup Observations  

Microsoft Academic Search

The Taiwan-American Occultation Survey (TAOS) project is aimed to find Kuiper Belt Objects (KBO) and measure their size distribution using the occultation technique. The TAOS project employed four 20-inch wide-field (F\\/1.9, 3 degree-squared FOV) telescopes, equipped with a 2K x 2K CCD, to simultaneously monitor the same patch of the sky. All four TAOS telescopes, which can be operated automatically,

Chow Choong Ngeow; D. Chang; K. Pan; T. Chung; E. Koptelova

2010-01-01

31

Thyroid associated orbitopathy--medication, radioiodine or operation?  

PubMed

This paper presents the current state of knowledge on the treatment of ophthalmopathy in the process of the Grave's disease. The question of prevention occupies a special place in the process of treatment as it has been clearly shown that exophthalmos is strongly associated with cigarette smoking. Therefore, before proceeding with any treatment, the patient should be advised to quit smoking as soon as possible. Further on in the publication, various forms of therapy are presented. Because of the unknown etiology, only symptomatic treatment can be applied, which includes steroids, radiotherapy and surgery. Patient care of patients with ophthalmopathy is a challenge even for an experienced clinician. Each case requires an individual approach that would take into account the severity of eye changes. PMID:23421110

Czarnywojtek, Agata; Zgorzalewicz-Stachowiak, Ma?gorzata; Stangierski, Adam; Florek, Ewa; Zdanowska, Joanna; Katarzyna, Hen; Andrzejewska, Magdalena; Rucha?a, Marek

2012-01-01

32

Rectus muscle resection in Graves' ophthalmopathy  

PubMed Central

BACKGROUND In the treatment of Graves’ ophthalmopathy, rectus muscle resections generally are avoided because of the concern of reaggravating inflammation and creating excessive extraocular muscle restriction. In patients with large-angle strabismus and in patients with residual strabismus after maximal recession surgery, however, rectus muscle resection may be considered. We report a series of 8 patients with Graves’ ophthalmopathy who underwent rectus muscle resections. METHODS The records of 270 patients with Graves’ ophthalmopathy who had undergone strabismus surgery were retrospectively reviewed. Data from subjects who had undergone rectus muscle resections were collected, including age at surgery, duration of disease, duration of diplopia, previous eye or strabismus surgeries, history of radioactive iodine or corticosteroid treatment, current thyroid medications, current use of corticosteroids, tobacco use, and signs and symptoms used to diagnose Graves’ ophthalmopathy. RESULTS Eight patients (5 females) were identified (mean age, 51.1 ± 17.6 years). Preoperatively, 4 patients had a horizontal deviation and 4 patients had both horizontal and vertical deviations in primary gaze. Mean preoperative horizontal deviation was 27.9? ± 15.2? and mean vertical deviation was 6.3? ± 5.4?. At final follow-up examination, 7 patients were orthotropic in primary gaze; 1 patient had a larger deviation from slippage as the result of a broken suture within the first postoperative week. None of the patients were overcorrected or developed atypical inflammation. CONCLUSIONS In this series, patients with Graves’ ophthalmology were successfully treated with the use of rectus muscle resections as part of the surgical plan. Careful ocular motility assessment and patient selection is critical if this option is contemplated.

Yoo, Sylvia H.; Pineles, Stacy L.; Goldberg, Robert A.; Velez, Federico G.

2013-01-01

33

Graves' ophthalmopathy: natural history and treatment outcomes  

Microsoft Academic Search

Background: The pathogenesis of Graves' oph- thalmopathy has not been yet clarified, and from a therapeutic standpoint Graves' ophthalmopathy remains an enigma. The natural course and effects of different treatment regimens are poorly docu- mented. Results: The mean observation period was 3.23 years (1-8.9 years) for all 196 patients, and 2.85 years (1-8.9 years) for the 81 patients with Graves'

Daniel Noth; Mathias Gebauer; Bruno Müller; Ulrich Bürgi; Peter Diem

34

2009 American Thyroid Association guidelines on thyroid nodules.  

PubMed

The American Thyroid Association guidelines on thyroid nodules and differentiated thyroid cancer, published in 2009, provide valuable recommendations based on current evidence. Inevitably, controversies and uncertainties will continue to challenge clinicians and patients. On topics where evidence is not clear-cut, judgement may be coloured by pre-existing practises and the structure of the health service in each country, so one has to be aware of the pitfalls of transferring recommendations to one's own practise. PMID:20653084

Perros, P

2010-08-01

35

Rituximab therapy in steroid-resistant severe hypothyroid Grave's ophthalmopathy.  

PubMed

Association of Grave's ophthalmopathy with hyperthyroidism is well known, and it has also been reported in euthyroid or hypothyroid autoimmune thyroiditis, which rarely requires treatment. Here, we report a case of bilaterally symmetrical severe corticosteroid-resistant hypothyroid Grave's ophthalmopathy successfully treated with rituximab. PMID:23776919

Pandit, Aditi; Gundgurthi, Abhay; Kharb, Sandeep; Brar, Karninder S; Garg, M K

2013-03-01

36

Update on TAO moored ORG array  

NASA Technical Reports Server (NTRS)

During the Coupled Ocean Atmosphere Response Experiment (COARE) six TAO moorings were equipped with optical rain gauges (ORG's). In late 1993 moorings deployed on the equator at 154E and 157.5E were recovered and not redeployed as they were augmentations to the TAO array for COARE only. In December 1993, four TAO moorings were equipped with ORG's: one each at 2N, 156E and 2S, 156E and ORG doublets on the equator at 0, 156E and 0, 165E. The 2N, 156E mooring has been lost. By the end of April all sites will have been serviced and six refurbished sensors will again be deployed in the same locations.

Freitag, H. Paul

1994-01-01

37

The Influence of Prior Hyperthyroidism on Euthyroid Graves' Ophthalmopathy  

PubMed Central

Background. To investigate the influence of previous exposure to elevated thyroid hormones in euthyroid Graves' ophthalmopathy. Design. Retrospective, observational case series in university setting Median follow-up of 1 year with ranges of 0,8–7,6 years. Study performance of 10 years. Participants. We reviewed the clinical records of 731 Graves' ophthalmopathy patients. There were 88 (12%) patients with onset of Graves' ophthalmopathy during euthyroidism: 37 (5%) patients had ophthalmopathy without known history of thyroid dysfunction (group A) and 51 patients (6%) had onset of ophthalmopathy 6 months or more euthyroid after completion of antithyroid therapy (group B). Main Outcome Measures. Graves' ophthalmopathy was graded using the EUGOGO severity criteria. Unilaterality was investigated. TSH receptor antibody and thyroid peroxidase antibody were measured as markers of Graves' disease. Results. Group A had more often a normal ocular motility (46%) and less proptosis (14 ± 4?mm) compared to group B (22%, 16 ± 4?mm) (P = 0.032 and 0.028, resp.). TSH receptor antibody was more frequently elevated in group B (94%) than in group A (17%) (P < 0.001). Conclusion. Patients with euthyroid Graves' ophthalmopathy present more often with ocular muscle restriction and proptosis when previously exposed to elevated thyroid hormones.

Mombaerts, Ilse

2014-01-01

38

Graves' dermopathy and acropachy are markers of severe Graves' ophthalmopathy.  

PubMed

It is generally considered that thyroid dermopathy and acropachy almost always occur with Graves' ophthalmopathy and that these two extrathyroidal manifestations are indicators of severe autoimmune disease and hence of more severe ophthalmopathy. However, documentation of these anecdotal impressions is needed. We assessed the presence of optic neuropathy and frequency of orbital decompression in 2 referral cohorts: 40 patients with acropachy and dermopathy (acropachy group) and 138 patients with Graves' dermopathy and no acropachy (dermopathy group). We compared those cohorts with a cohort of 114 patients who had ophthalmopathy without dermopathy and acropachy (control group). We considered optic neuropathy and the need for orbital decompression to be indicators of severe Graves' ophthalmopathy. The frequency of orbital decompression was significantly higher in the dermopathy group than in the control group (odds ratio, 3.55) and even higher in the acropachy group (odds ratios: 20.68 for acropachy group compared with control group; 5.83 for acropachy group compared with dermopathy group). The same trend occurred with optic neuropathy but was not statistically significant (alpha = 0.05; p = 0.07). Five patients were exceptions: they had definite Graves' dermopathy without clinically obvious ophthalmopathy. In conclusion, dermopathy and acropachy appear to be markers of severe ophthalmopathy. Occasionally, however, Graves' dermopathy occurs without clinical ophthalmopathy. PMID:14751035

Fatourechi, Vahab; Bartley, George B; Eghbali-Fatourechi, Guiti Z; Powell, Claudia C; Ahmed, Debra D F; Garrity, James A

2003-12-01

39

The influence of prior hyperthyroidism on euthyroid graves' ophthalmopathy.  

PubMed

Background. To investigate the influence of previous exposure to elevated thyroid hormones in euthyroid Graves' ophthalmopathy. Design. Retrospective, observational case series in university setting Median follow-up of 1 year with ranges of 0,8-7,6 years. Study performance of 10 years. Participants. We reviewed the clinical records of 731 Graves' ophthalmopathy patients. There were 88 (12%) patients with onset of Graves' ophthalmopathy during euthyroidism: 37 (5%) patients had ophthalmopathy without known history of thyroid dysfunction (group A) and 51 patients (6%) had onset of ophthalmopathy 6 months or more euthyroid after completion of antithyroid therapy (group B). Main Outcome Measures. Graves' ophthalmopathy was graded using the EUGOGO severity criteria. Unilaterality was investigated. TSH receptor antibody and thyroid peroxidase antibody were measured as markers of Graves' disease. Results. Group A had more often a normal ocular motility (46%) and less proptosis (14 ± 4?mm) compared to group B (22%, 16 ± 4?mm) (P = 0.032 and 0.028, resp.). TSH receptor antibody was more frequently elevated in group B (94%) than in group A (17%) (P < 0.001). Conclusion. Patients with euthyroid Graves' ophthalmopathy present more often with ocular muscle restriction and proptosis when previously exposed to elevated thyroid hormones. PMID:25045529

Termote, Karolien; Decallonne, Brigitte; Mombaerts, Ilse

2014-01-01

40

The Transneptunian Automated Occultation Survey (TAOS II)  

NASA Astrophysics Data System (ADS)

The Transneptunian Automated Occultation Survey (TAOS II) will aim to detect occultations of stars by small ( 1 km diameter) objects in the Solar System and beyond. Such events are very rare (< 10-3 events per star per year) and short in duration ( 200 ms), so many stars must be monitored at a high readout cadence. TAOS II will operate three 1.3 meter telescopes at the Observatorio Astro?omico Nacional at San Pedro Martir in Baja California, Mexico. With a 2.3 square degree field of view and a high speed camera comprising CMOS imagers, the survey will monitor 10,000 stars simultaneously with all three telescopes at a readout cadence of 20 Hz.

Lehner, Matthew J.; Wang, Shiang-Yu; Alcock, Charles A.; Cook, Kem H.; Furesz, Gabor; Geary, John C.; Hiriart, David; Ho, Paul T.; Lee, William; Melsheimer, Frank; Norton, Timothy; Reyes-Ruiz, Mauricio; Richer, Michael; Szentgyorgyi, Andrew; Yen, Wei-Ling; Zhang, Zhi-Wei

2012-09-01

41

The Transneptunian Automated Occultation Survey (TAOS II)  

NASA Astrophysics Data System (ADS)

The Transneptunian Automated Occultation Survey (TAOS II) will aim to detect occultations of stars by small ( 1 km diameter) objects in the Solar System and beyond. Such events are very rare (<0.001 events per star per year) and short in duration ( 200 ms), so many stars must be monitored at a high readout cadence. TAOS II will operate three 1.3 meter telescopes at the Observatorio Astronómico Nacional at San Pedro Mártir in Baja California, México. With a 2.3 square degree field of view and a high speed camera comprising CMOS imagers, the survey will monitor 10,000 stars simultaneously with all three telescopes at a readout cadence of 20 Hz.

Lehner, Matthew J.; Wang, S.; Alcock, C. A.; Cook, K. H.; Furesz, G.; Geary, J. C.; Hiriart, D.; Ho, P. T.; Norton, T.; Reyes-Ruiz, M.; Szentgyorgyi, A.; Yen, W.; Zhang, Z.

2012-10-01

42

Thyroid-associated orbitopathy: who and how to treat.  

PubMed

Thyroid-associated orbitopathy is the most frequent and troublesome nonthyroidal complication of Graves' disease. It is mandatory to determine whether sight-threatening orbitopathy is present, as this requires prompt and aggressive treatment. Therapies for non-sight-threatening disease range from supportive measures only to medical therapies for active eye disease and surgical rehabilitation for burnt-out disease. Intravenous steroids and orbital radiotherapy are the mainstays of medical therapy. Rehabilitative surgery is frequently a staged process that may involve sequentially: orbital decompression, strabismus surgery, and eyelid procedures. Smoking cessation is recommended at all disease stages. Treatment within a multidisciplinary team consisting of both endocrinologists and ophthalmologists may lead to optimal patient outcomes. PMID:19328417

Dickinson, Jane; Perros, Petros

2009-06-01

43

Graves' Ophthalmopathy: A Review of Immunogenetics  

PubMed Central

Graves’ disease (GD) is the most common cause of thyrotoxicosis and often involves the orbits. Graves’ ophthalmopathy (GO), also known as Thyroid Eye Disease (TED), can be clinically significant and advance to sight-threatening stages. Our knowledge of the immunogenetic pathophysiology of GO is rapidly expanding. The present review is an attempt to summarize the current state of knowledge on the immunogenetics of GO. First we briefly review the epidemiology and clinical importance of GO, and then we describe in detail the macromolecular pathogenesis and finally immunogenetics of GO. Discrepancies between the results from various reports and the limitations of the available data are discussed. In particular, there is a scarcity of data from non-Asian populations. While several studies have demonstrated significant associations between polymorphisms in certain genes (especially CTLA-4, HLA-DRB-1, and TNF-?), there is a need for studies that investigate the relationship between polymorphisms and both serum and local concentrations of the resulting proteins. A complete understanding of GO susceptibility and pathogenesis has not been yet possible due to a number of important knowledge gaps that need to be filled by future research.

Khalilzadeh, Omid; Noshad, Sina; Rashidi, Armin; Amirzargar, Aliakbar

2011-01-01

44

Graves' ophthalmopathy: eye muscle involvement in patients with diplopia  

Microsoft Academic Search

Background: Diplopia identifies patients with eye muscle involvement in Graves' ophthalmopathy (GO). Objective: To identify clinical parameters that could eliminate the need for magnetic resonance imaging (MRI) to assess the activity of inflammation in the eye muscles of GO patients with diplopia. Methods: In 43 patients with GO with recently developed diplopia, orbital ultrasound and MRI were performed. Muscle diameters

E. Nagy; Judit Toth; Ildiko Kaldi; Judit Damjanovich; Emese Mezosi; Agota Lenkey; Laszlo Toth; Jeno Szabo; Zsolt Karanyi; Andras Leovey

2000-01-01

45

Clinical Study of Ophthalmopathy in Patients with Graves' Disease  

Microsoft Academic Search

Aim: The aim of this study was to evaluate ophthalmopathy in patients with Graves' disease according to sex, age, and duration of the disease. Patients and Methods: Ninety five patients with Graves' disease were included in the study. Sixty two percent of patients were women and 38% were men. All patients underwent a complete ophthalmic examination. Results: The frequency of

Mohammad Reza Besharati; Abolghasem Rastegar

46

Trajectory analysis and optimization system (TAOS) user`s manual  

SciTech Connect

The Trajectory Analysis and Optimization System (TAOS) is software that simulates point--mass trajectories for multiple vehicles. It expands upon the capabilities of the Trajectory Simulation and Analysis program (TAP) developed previously at Sandia National Laboratories. TAOS is designed to be a comprehensive analysis tool capable of analyzing nearly any type of three degree-of-freedom, point-mass trajectory. Trajectories are broken into segments, and within each segment, guidance rules provided by the user control how the trajectory is computed. Parametric optimization provides a powerful method for satisfying mission-planning constraints. Althrough TAOS is not interactive, its input and output files have been designed for ease of use. When compared to TAP, the capability to analyze trajectories for more than one vehicle is the primary enhancement, although numerous other small improvements have been made. This report documents the methods used in TAOS as well as the input and output file formats.

Salguero, D.E.

1995-12-01

47

Evidence for thyrotropin receptor immunoreactivity in pretibial connective tissue from patients with thyroid-associated dermopathy  

Microsoft Academic Search

Pretibial myxedema (PTM), mainly characterized by the accumulation of glycosaminoglycans in the dermis and subcutaneous tissue, is an extrathyroidal manifestation of autoimmune Graves' disease (GD), almost always associated with Graves' ophthalmopathy (GO). The thyrotropin receptor (TSH- R) has been proposed as the common target antigen in GD, GO and PTM, with evidence for receptor transcripts and\\/or protein in these locations.

C Daumerie; M Ludgate; S Costagliola

2002-01-01

48

TAO-robust backpropagation learning algorithm.  

PubMed

In several fields, as industrial modelling, multilayer feedforward neural networks are often used as universal function approximations. These supervised neural networks are commonly trained by a traditional backpropagation learning format, which minimises the mean squared error (mse) of the training data. However, in the presence of corrupted data (outliers) this training scheme may produce wrong models. We combine the benefits of the non-linear regression model tau-estimates [introduced by Tabatabai, M. A. Argyros, I. K. Robust Estimation and testing for general nonlinear regression models. Applied Mathematics and Computation. 58 (1993) 85-101] with the backpropagation algorithm to produce the TAO-robust learning algorithm, in order to deal with the problems of modelling with outliers. The cost function of this approach has a bounded influence function given by the weighted average of two psi functions, one corresponding to a very robust estimate and the other to a highly efficient estimate. The advantages of the proposed algorithm are studied with an example. PMID:15795116

Pernía-Espinoza, Alpha V; Ordieres-Meré, Joaquín B; Martínez-de-Pisón, Francisco J; González-Marcos, Ana

2005-03-01

49

Graves disease with ophthalmopathy following radiotherapy for Hodgkin's disease  

SciTech Connect

The number of patients achieving long-term survival following neck irradiation for Hodgkin's disease and other malignancies is increasing. Paralleling this increase in survivors is the development of late complications of the therapy itself. Eleven patients have previously been reported who developed Graves ophthalmopathy 18 months to seven years after receiving neck radiotherapy for nonthyroidal malignancies. The seven patients who had HLA typing were all HLA-B8 negative, despite the reported association of the HLA-B8 antigen with Graves disease. A patient who is HLA-B8 positive who developed Graves ophthalmopathy and hyperthyroidism nine years after receiving mantle radiotherapy for Hodgkin's disease is reported. It is recommended that Graves disease be included among the thyroid diseases that receive consideration during follow-up of patients who have received mantle radiotherapy.

Jacobson, D.R.; Fleming, B.J.

1984-12-01

50

The effect of etanercept on Graves' ophthalmopathy: a pilot study  

Microsoft Academic Search

PurposeTo assess the effect of etanercept, an antitumour necrosis factor (anti-TNF) drug, on clinical signs in Graves' ophthalmopathy (GO).MethodsA total of 10 consecutive patients (seven female, three male) with recent-onset, active, mildly-to-moderately severe GO were treated with subcutaneous injections of 25 mg etanercept (Enbrel®) twice weekly during 12 weeks. The average age was 50 years (range: 39–59 years). The average

D Paridaens; W A van den Bosch; T L van der Loos; E P Krenning; P M van Hagen

2005-01-01

51

Synovial osteochondromatosis in hereditary arthro-ophthalmopathy (Wagner-Stickler syndrome)  

Microsoft Academic Search

A case of bilateral synovial osteochondromatosis in a patient with hereditary arthro-ophthalmopathy is presented. The osteochondral lesions were largely calcified in one joint and largely chondromatous in the other. Typical features of hereditary arthro-ophthalmopathy are reviewed and it is hypothesised that the abnormal collagen in this syndrome is responsible for the development of synovial osteochondromatosis. Synovial manifestations of skeletal dysplasias

Bernhard Tins; Victor Cassar-Pullicino

2003-01-01

52

The TAOS Project: High-Speed Crowded Field Aperture Photometry  

NASA Astrophysics Data System (ADS)

We have devised an aperture photometry pipeline for data reduction of image data from the Taiwanese-American Occultation Survey (TAOS). The photometry pipeline has high computational performance, and is capable of real-time photometric reduction of images containing up to 1000 stars, within the sampling rate of 5 Hz. The pipeline is optimized for both speed and signal-to-noise performance, and in the latter category it performs nearly as well as DAOPHOT. This paper provides a detailed description of the TAOS aperture photometry pipeline.

Zhang, Z.-W.; Kim, D.-W.; Wang, J.-H.; Lehner, M. J.; Chen, W. P.; Byun, Y.-I.; Alcock, C.; Axelrod, T.; Bianco, F. B.; Coehlo, N. K.; Cook, K. H.; Dave, R.; de Pater, I.; Giammarco, J.; King, S.-K.; Lee, T.; Lin, H.-C.; Marshall, S. L.; Porrata, R.; Protopapas, P.; Rice, J. A.; Schwamb, M. E.; Wang, S.-Y.; Wen, C.-Y.

2009-12-01

53

75 FR 66345 - Proposed Amendment of Class E Airspace; Taos, NM  

Federal Register 2010, 2011, 2012, 2013

...amend Class E airspace at Taos, NM. Decommissioning of the Ski non-directional beacon (NDB) at Taos Regional Airport, Taos...reconfiguration is necessary due to the decommissioning of the Ski NDB and the cancellation of the NDB approach, and would...

2010-10-28

54

Digital Aeromagnetic Data and Derivative Products from a Helicopter Survey over the Town of Taos and Surrounding Areas, Taos County, New Mexico  

USGS Publications Warehouse

This report contains digital data, image files, and text files describing data formats and survey procedures for aeromagnetic data collected during a helicopter geophysical survey in northern New Mexico during October 2003. The survey covers the Town of Taos, Taos Pueblo, and surrounding communities in Taos County. Several derivative products from these data are also presented, including reduced-to-pole, horizontal gradient magnitude, and downward continued grids and images.

Bankey, Viki; Grauch, V. J. S.; Fugro Airborne Surveys Corporation

2004-01-01

55

77 FR 38375 - Notice of Availability of the Final Environmental Impact Statement (FEIS) for the Taos Regional...  

Federal Register 2010, 2011, 2012, 2013

The FAA is issuing this Notice to advise the public that it has prepared a Final Environmental Impact Statement (FEIS) for a proposed new runway and associated facilities and improvements at the Taos Regional Airport, Taos, New Mexico. The FEIS reflects the Section 106 consultations between the FAA, the Taos Pueblo, Town of Taos, National Park Service, Advisory Council on Historic Preservation,......

2012-06-27

56

The diagnosis and management of hyperthyroidism in Korea: consensus report of the korean thyroid association.  

PubMed

Hyperthyroidism is one of the causes of thyrotoxicosis and the most common cause of hyperthyroidism in Korea is Graves disease. The diagnosis and treatment of Graves disease are different according to geographical area. Recently, the American Thyroid Association and the American Association of Clinical Endocrinologists suggested new management guidelines for hyperthyroidism. However, these guidelines are different from clinical practice in Korea and are difficult to apply. Therefore, the Korean Thyroid Association (KTA) conducted a survey of KTA members regarding the diagnosis and treatment of hyperthyroidism, and reported the consensus on the management of hyperthyroidism. In this review, we summarized the KTA report on the contemporary practice patterns in the diagnosis and management of hyperthyroidism, and compared this report with guidelines from other countries. PMID:24396691

Moon, Jae Hoon; Yi, Ka Hee

2013-12-01

57

Thyroid autoimmunity and ophthalmopathy related to melanoma biologic therapy  

PubMed Central

Ipilimumab is a fully human monoclonal antibody against Cytotoxic TLymphocyte Antigen 4 (CTLA-4). CTLA-4 negatively regulates immune cell activation. In patients with metastatic melanoma, ipilimumab increases survival time and induces complete remission in some patients. However, immune related adverse events including endocrinopathies have been reported. Bevacizumab, an angiogenesis inhibitor, has been used in combination with ipilimumab in patients with advanced melanoma. Here, we report three patients who received ipilimumab alone or with bevacizumab therapy and developed thyroiditis and the first report of euthyroid Graves’ ophthalmopathy. Case 1 is a 51 year old female who presented with severe eye pain, proptosis and periorbital edema. Laboratory results revealed normal TSH, elevated thyroid antibodies but low titer of anti-thyrotropin receptor antibody. Imaging was consistent with Graves’ ophthalmopathy. Cases 2 and 3 were referred for hyperthyroidism and work up revealed thyroiditis. These 3 cases suggest that patients with advanced melanoma treated with ipilimumab +/- bevacizumab may be susceptible to a variety of thyroid disorders. Anti-CTLA4 therapy has shown promising results in treating advanced malignancy such as melanoma and renal carcinoma. A number of endocrinopathies, including thyroid disorders, may develop during ipilimumab therapy. The association of bevacizumab with endocrinopathies is not clear although a few reports suggest a link to hypothyroidism. All patients on ipilimumab and/or bevacizumab therapy should be monitored for signs or symptoms of thyroiditis.

Min, Le; Vaidya, Anand; Becker, Carolyn

2014-01-01

58

Glucocorticoid-Induced Disappearance of Long-Acting Thyroid Stimulator in the Ophthalmopathy of Graves' Disease.  

National Technical Information Service (NTIS)

The effect of glucocorticoid therapy on serum longacting thyroid stimulator (LATS) was studied in 3 subjects. In a patient with severe ophthalmopathy and pretibial myxedema, prednisone treatment induced a clinical remission and disappearance of an initial...

N. J. Snyder D. E. Green D. H. Solomon

1964-01-01

59

Status of the Transneptunian Automated Occultation Survey (TAOS II)  

NASA Astrophysics Data System (ADS)

The Transneptunian Automated Occultation Survey (TAOS II) will aim to detect occultations of stars by small 1 km diameter) objects in the Transneptunian region and beyond. Such events are very rare (< 10-3 events per star per year) and short in duration (˜200 ms), so many stars must be monitored at a high readout cadence. TAOS II will operate three 1.3 meter telescopes at the Observatorio Astronómico Nacional at San Pedro Mártir in Baja California, México. With a 2.3 square degree field of view and high speed cameras comprising CMOS imagers, the survey will monitor 10,000 stars simultaneously with all three telescopes at a readout cadence of 20 Hz. In this presentation, we will describe the project in detail and discuss the progress on the development of the survey infrastructure.

Lehner, Matthew; Wang, S.; Ho, P.; Zhang, Z.; Cook, K.; Yen, W.; Reyes-Ruiz, M.; Hiriart, D.; Richer, M.; Alcock, C.; Szentgyorgyi, A.; Geary, J.; Norton, T.; Furesz, G.

2013-10-01

60

THE TAOS PROJECT: RESULTS FROM SEVEN YEARS OF SURVEY DATA  

SciTech Connect

The Taiwanese-American Occultation Survey (TAOS) aims to detect serendipitous occultations of stars by small ({approx}1 km diameter) objects in the Kuiper Belt and beyond. Such events are very rare (<10{sup -3} events per star per year) and short in duration ({approx}200 ms), so many stars must be monitored at a high readout cadence. TAOS monitors typically {approx}500 stars simultaneously at a 5 Hz readout cadence with four telescopes located at Lulin Observatory in central Taiwan. In this paper, we report the results of the search for small Kuiper Belt objects (KBOs) in seven years of data. No occultation events were found, resulting in a 95% c.l. upper limit on the slope of the faint end of the KBO size distribution of q = 3.34-3.82, depending on the surface density at the break in the size distribution at a diameter of about 90 km.

Zhang, Z.-W.; Lehner, M. J.; Wang, J.-H.; Wen, C.-Y.; Wang, S.-Y.; King, S.-K.; Cook, K. H.; Lee, T. [Institute of Astronomy and Astrophysics, Academia Sinica. 11F of Astronomy-Mathematics Building, National Taiwan University. No. 1, Sec. 4, Roosevelt Road, Taipei 10617, Taiwan (China); Granados, A. P. [Instituto de Astronomia, Universidad Nacional Autonoma de Mexico, Apdo. Postal 106, Ensenada, Baja California 22800 (Mexico); Alcock, C.; Protopapas, P. [Harvard-Smithsonian Center for Astrophysics, 60 Garden Street, Cambridge, MA 02138 (United States); Axelrod, T. [Steward Observatory, 933 North Cherry Avenue, Room No. 204, Tucson AZ 85721 (United States); Bianco, F. B. [Center for Cosmology and Particle Physics, New York University, 4 Washington Place, New York, NY 10003 (United States); Byun, Y.-I. [Department of Astronomy and University Observatory, Yonsei University, 134 Shinchon, Seoul 120-749 (Korea, Republic of); Chen, W. P. [Institute of Astronomy, National Central University, No. 300, Jhongda Road, Jhongli City, Taoyuan County 320, Taiwan (China); Coehlo, N. K. [Department of Statistics, University of California Berkeley, 367 Evans Hall, Berkeley, CA 94720 (United States); De Pater, I. [Department of Astronomy, University of California Berkeley, 601 Campbell Hall, Berkeley, CA 94720 (United States); Kim, D.-W. [Max Planck Institute for Astronomy, Koenigstuhl 17, D-69117 Heidelberg (Germany); Lissauer, J. J. [Space Science and Astrobiology Division 245-3, NASA Ames Research Center, Moffett Field, CA 94035 (United States); Marshall, S. L., E-mail: zwzhang@asiaa.sinica.edu.tw [Kavli Institute for Particle Astrophysics and Cosmology, 2575 Sand Hill Road, MS 29, Menlo Park, CA 94025 (United States); and others

2013-07-01

61

TAO1 kinase maintains chromosomal stability by facilitating proper congression of chromosomes  

PubMed Central

Chromosomal instability can arise from defects in chromosome–microtubule attachment. Using a variety of drug treatments, we show that TAO1 kinase is required for ensuring the normal congression of chromosomes. Depletion of TAO1 reduces the density of growing interphase and mitotic microtubules in human cells, showing TAO1's role in controlling microtubule dynamics. We demonstrate the aneugenic nature of chromosome–microtubule attachment defects in TAO1-depleted cells using an error-correction assay. Our model further strengthens the emerging paradigm that microtubule regulatory pathways are important for resolving erroneous kinetochore–microtubule attachments and maintaining the integrity of the genome, regardless of the spindle checkpoint status.

Shrestha, Roshan L.; Tamura, Naoka; Fries, Anna; Levin, Nicolas; Clark, Joanna; Draviam, Viji M.

2014-01-01

62

The association of carotid cavernous fistula with Graves' ophthalmopathy  

PubMed Central

Graves’ ophthalmopathy (GO) is one of the frequent manifestations of the disorder which is an inflammatory process due to fibroblast infiltration, fibroblast proliferation and accumulation of glycosaminoglycans. Eye irritation, dryness, excessive tearing, visual blurring, diplopia, pain, visual loss, retroorbital discomfort are the symptoms and they can mimic carotid cavernous fistulas. Carotid cavernous fistulas are abnormal communications between the carotid arterial system and the cavernous sinus. The clinical manifestations of GO can mimic the signs of carotid cavernous fistulas. Carotid cavernous fistulas should be considered in the differential diagnosis of the GO patients especially who are not responding to the standard treatment and when there is a unilateral or asymmetric eye involvement. Here we report the second case report with concurrent occurrence of GO and carotid cavernous fistula in the literature.

Celik, Ozlem; Buyuktas, Deram; Islak, Civan; Sarici, A Murat; Gundogdu, A Sadi

2013-01-01

63

Update on the medical treatment of Graves' ophthalmopathy  

PubMed Central

Purpose: To review recent advances in the understanding of Graves’ ophthalmopathy (GO) pathogenesis as well as discuss current and future medical management strategies. Design: Interpretive essay. Methods: Literature review and interpretation. Results: Medical treatment of GO has slowly evolved during the past few decades and has been hampered by a poor understanding of the disease at a cellular and molecular level. Current treatment recommendations and guidelines therefore focus on nonspecific immuno-suppression. Newer classes of treatment agents hold promise to more selectively target underlying cellular and molecular alterations in GO. Conclusion: Cooperation between individual patients, physicians and between differing medical centers, together with a refined understanding of the pathogenesis of GO, will lead to newer more-effective treatments for the disease and improve patient quality of life.

Griepentrog, Gregory J; Garrity, James A

2009-01-01

64

Medullary Thyroid Cancer: Are Practice Patterns in the United States Discordant From American Thyroid Association Guidelines?  

Microsoft Academic Search

Background  Surgery is the mainstay of treatment for medullary thyroid cancer (MTC), with long-term patient outcomes associated with adequacy\\u000a of resection. This study benchmarked national practice patterns against 2009 American Thyroid Association (ATA) guidelines\\u000a for MTC regarding use of thyroidectomy, lymphadenectomy, radioactive iodine (RAI), and external-beam radiotherapy (EBRT).\\u000a \\u000a \\u000a \\u000a \\u000a Methods  This is a cross-sectional, retrospective cohort study of MTC patients in the Surveillance,

Babita Panigrahi; Sanziana A. Roman; Julie Ann Sosa

2010-01-01

65

Use of corticosteroids to prevent progression of Graves' ophthalmopathy after radioiodine therapy for hyperthyroidism  

SciTech Connect

We studied the effects of radioiodine treatment of hyperthyroidism due to Graves' disease on Graves' ophthalmopathy and the possible protective role of corticosteroids. Between June 1985 and June 1988, 26 patients were randomly assigned to treatment with radioiodine alone (group 1) and 26 to treatment with this agent and concomitant administration of systemic prednisone for four months (group 2). The initial dose of prednisone was 0.4 to 0.5 mg per kilogram of body weight for one month; the drug was gradually withdrawn over the next three months. All patients were evaluated at 3-month intervals for 18 months after they underwent radioiodine therapy. Ocular changes were assessed with the ophthalmopathy index; patients with moderate-to-severe changes (scores greater than or equal to 4) were excluded from the study. Before treatment, 10 patients in group 1 and 5 in group 2 had no evidence of ophthalmopathy: in none of them did ocular symptoms appear after radioiodine therapy. Among the patients in group 1 with an initial ophthalmopathy index greater than or equal to 1, ocular disease worsened in 56 percent (mostly involving soft-tissue changes and extraocular-muscle function) and did not change in 44 percent. In contrast, ophthalmopathy improved in 52 percent and did not change in 48 percent of group 2. The mean ophthalmopathy index increased from 1.5 to 3.0 in group 1 (P less than 0.005) and decreased from 2.2 to 1.3 in group 2 (P less than 0.05). We conclude that systemic corticosteroid treatment prevents the exacerbations of Graves' ophthalmopathy that occur after radioiodine therapy in a substantial proportion of patients with hyperthyroidism who have some degree of ocular involvement before treatment.

Bartalena, L.; Marcocci, C.; Bogazzi, F.; Panicucci, M.; Lepri, A.; Pinchera, A. (Univ. of Pisa (Italy))

1989-11-16

66

Pliocene Volcanic Evolution of the Taos Plateau, New Mexico  

NASA Astrophysics Data System (ADS)

New geologic mapping (1:24k-1:50k scale) and high precision 40Ar/39Ar geochronology of volcanic rocks from the Taos Plateau in northern New Mexico reveals nearly 4 million years of predominantly mafic (basalt to andesite) volcanism associated with the Pliocene to Quaternary Rio Grande rift. A nearly continuous record of volcanism is recorded from ~5 to ~1 Ma with two major pulses of magmatism observed at ~4.5 Ma and ~3 Ma reflecting eruption from more than 50 mapped centers and an unresolved number of centers buried by intercalated rift volcanics and sedimentary basin fill. Volcanism, both outflow thickness and vent locations, is strongly controlled by the same north to northwest trending fault systems defining the Rio Grande rift graben. However, active loci of volcanism can be linked to sub-basins within the broader graben structure. Large composite volcanoes ranging in composition from basaltic andesite to andesite, such as Guadeloupe Mountain (~4.5-5 Ma), Ute Mountain (~3.9 Ma), and San Antonio Mountain (~3 Ma) formed over time intervals of about 300 ka during the most voluminous stages of activity. Similar time intervals are recorded in each of three Servilleta basalt flow packages (lower (~4.5 Ma), middle (~4 Ma), and upper (~3.5 Ma)) observed at the Rio Grande gorge just north of Taos that first began erupting at ~ 4.7 Ma. Distinctive reddish paleosols between each Servilleta flow package represent time intervals between eruptions of ~0.5 Ma. Late stage volcanic activity (< 3 Ma) is recorded as small volume Servilleta basalt volcanoes and numerous small basalt to basaltic andesite cinder cones and associated lavas flows. Mesita Cone, dated at ~ 1 Ma and offset by middle Pleistocene faulting, represents the youngest volcanic activity within the Taos plateau segment of the Rio Grande Rift. The Pliocene to Quaternary volcanic rocks of the Taos Plateau are locally underlain by 1) Precambrian crystalline granite basement, 2) Oligocene calc-alkaline volcanic and associated intrusive rocks of the southern Rocky Mountain volcanic field, 3) a mafic to intermediate composition Miocene volcanic platform in the northern part of the plateau, or 4) Miocene to Quaternary basin-fill deposits in actively subsiding extensional sub-basins of the eastern plateau. The stratigraphic relationship of this Pliocene volcanism to the earlier igneous activity, mapped faults, and erosional unconformities establishes temporal constraints on regional extension prior to Pliocene rifting. Preliminary 40Ar/39Ar results and integrated mapping support an interpretation of contemporaneous rift sub-basin development and Pliocene volcanism as the primary manifestation of continental rifting vs. regional extension in northern New Mexico.

Cosca, M. A.; Thompson, R. A.; Turner, K. J.; Lee, J. P.

2012-12-01

67

Audiomagnetotelluric data, Taos Plateau Volcanic Field, New Mexico  

USGS Publications Warehouse

The U.S. Geological Survey is conducting a series of multidisciplinary studies of the San Luis Basin as part of the Geologic framework of the Rio Grande Basins project. Detailed geologic mapping, high-resolution airborne magnetic surveys, gravity surveys, audiomagnetotelluric surveys, and hydrologic and lithologic data are being used to better understand the aquifers. This report describes a regional east-west audiomagnetotelluric sounding profile acquired in late July 2009 across the Taos Plateau Volcanic Field. No interpretation of the data is included.

Ailes, Chad E.; Rodriguez, Brian D.

2011-01-01

68

Census of the Kuiper-Belt Objects --- The TAOS Project  

NASA Astrophysics Data System (ADS)

Thus far more than two hundred large (size more then 100 km) Kuiper-belt objects (KBOs) have been identified by direct imaging. Even smaller bodies, though expected to be more numerous on theoretical grounds, are much too faint to image directly. A KBO may reveal its existence, nevertheless, if it happens to block out the light from a background star. The Taiwan-America Occultation Survey (TAOS) project, a collaboration of the Lawrence Livermore Laboratory (USA), Academia Sinica, National Central University (both of Taiwan), and other institutes, aims to measure the frequency of such chance stellar occultations. Our experiment provides the only means to conduct the census of the Kuiper-belt population down to a few kilometer sizes. We are setting up an array of small (50 cm), wide-field (f/1.9) telescopes in Taiwan to monitor the brightness of some 3000 stars at a rate of 5 Hz. These robot telescopes will operate in a coincidence mode, so the sequence and timing of any candidate occultation event can be recorded and distinguished agaist a false detection. Other scientific byproducts, such as variable star studies, will conceivably also derive from this huge TAOS database, some 10,000 GB worth of photometrical measurements per year.

Chen, W. P.; Taos Team

69

Revised American Thyroid Association Management Guidelines for Patients with Thyroid Nodules and Differentiated Thyroid Cancer: The American Thyroid Association (ATA) Guidelines Taskforce on Thyroid Nodules and Differentiated Thyroid Cancer  

Microsoft Academic Search

Background: Thyroid nodules are a common clinical problem, and differentiated thyroid cancer is becoming increasingly prevalent. Since the publication of the American Thyroid Association's guidelines for the man- agement of these disorders was published in 2006, a large amount of new information has become available, prompting a revision of the guidelines. Methods: Relevant articles through December 2008 were reviewed by

David S. Cooper; Gerard M. Doherty; Bryan R. Haugen; Richard T. Kloos; Stephanie L. Lee; Susan J. Mandel; Ernest L. Mazzaferri; Bryan McIver; Furio Pacini; Martin Schlumberger; Steven I. Sherman; David L. Steward; R. Michael Tuttle

2009-01-01

70

[The overview of the surgical methods for the treatment of endocrine ophthalmopathy].  

PubMed

To analyse the efficacy of various surgical methods for the treatment of endocrine ophthalmopathy and to estimate the potential of endonasal endoscopic surgery for the management of this pathology. The available literature publications concerning surgical treatment of endocrine ophthalmopathy were reviewed; their data were compared with the results of endoscopic endonasal surgery performed by the authors. Various surgical techniques including those with the use of external and endonasal transethmoidal approachers are discussed with special emphasis on the resection of the medial and inferior orbital walls. The analysis of surgical techniques, peculiarities of postoperative treatment, and its outcomes is presented. This study has demonstrated the advantages of endonasal endoscopic transethmoidal decompression of the orbit over the external surgical approach used to manage endocrine ophthalmopathy. PMID:22833884

Kochetkov, P A; Savvateeva, D M

2012-01-01

71

Pulse dexamethasone therapy versus pulse methylprednisolone therapy for treatment of Graves's ophthalmopathy  

PubMed Central

Pulse methylprednisolone therapy is the recommended therapy for moderate to severe and active ophthalmopathy, but high dose pulse methylprednisolone therapy is marred by the chances of fulminant hepatic failure and the high cost of therapy. Dexamethasone pulse therapy can be considered as an alternative to pulse methylprednisolone therapy. A prospective randomized control trial was carried out in 21 patients comparing pulse dexamethasone therapy versus pulse methyprednisolone therapy in Graves's ophthalmopathy. This study proved that pulse dexamethasone therapy is a cheaper and equally effective therapy for Graves's ophthalmopathy and the cost of therapy is reduced to at least 1/8th s. Furthermore, dexa had a better effect on reduction of exophthalmos. The dreaded complication of fulminant hepatic failure, associated with high dose of methylprednisolone, is not seen with dexa therapy.

Philip, Rajeev; Saran, Sanjay; Gutch, Manish; Agroyia, Pushpaltha; Tyagi, Rajiv; Gupta, Keshavkumar

2013-01-01

72

Management of Hyperthyroidism in Pregnancy: Comparison of Recommendations of American Thyroid Association and Endocrine Society  

PubMed Central

Appropriate diagnosis and treatment of hyperthyroidism during pregnancy are of outmost importance, because hyperthyroidism has major adverse impact on both mother and fetus. Since data on the management of thyroid dysfunction during pregnancy is rapidly evolving, two guidelines have been developed by the American Thyroid Association and the Endocrine society in the last 2 years. We compare here the recommendations of these two guidelines regarding management of hyperthyroidism during pregnancy. The comparison reveals no disagreement or controversy on the various aspects of diagnosis and treatment of hyperthyroidism during pregnancy between the two guidelines. Propylthiouracil has been considered as the first-line drug for treatment of hyperthyroidism in the first trimester of pregnancy. In the second trimester, consideration should be given to switching to methimazole for the rest of pregnancy. Methimazole is also the drug of choice in lactating hyperthyroid women.

Alamdari, Shahram; Azizi, Fereidoun; Delshad, Hossein; Sarvghadi, Farzaneh; Amouzegar, Atieh; Mehran, Ladan

2013-01-01

73

Thyroid associated orbitopathy with ocular myasthenia in primary hypothyroidism: Keep those eyes open.  

PubMed

Thyroid associated orbitopathy, although seen most commonly with thyrotoxicosis, is also known to occur in primary hypothyroidism. Myasthenia gravis is an autoimmune condition with an established association with autoimmune thyroid disease. We report the case of a patient who presented with recent onset unilateral ptosis that was fatigable with a history of proptosis since a year. On examination, she had a goiter, bilateral proptosis, restriction of upward gaze and adduction both eyes and normal pupils. Investigations revealed primary hypothyroidism with anti-thyroid peroxidase positive and anti-acetylcholine receptor antibody positive. Computerized tomography orbit showed thickening of medial and inferior rectus characteristic of thyroid orbitopathy. A diagnosis of primary hypothyroidism with thyroid orbitopathy with ocular myasthenia gravis was made. Patient is on Levothyroxine and anticholinesterase medications and is on follow-up. We present this case to highlight that the presence of ptosis in a patient with thyroid orbitopathy should alert the clinician to the possible coexistence of myasthenia gravis. PMID:24910830

Selvan, Chitra; Dutta, Deep; Maisnam, Indira; Thukral, Anubhav; Chakraborthy, P P; Roy, Ajitesh; Arora, Rakesh; Dutta, Soumik; Baidya, Arjun; Ghosh, Sujoy; Mukhopadhyay, Satinath; Chowdhury, Subhankar

2013-12-01

74

Thyroid associated orbitopathy with ocular myasthenia in primary hypothyroidism: Keep those eyes open  

PubMed Central

Thyroid associated orbitopathy, although seen most commonly with thyrotoxicosis, is also known to occur in primary hypothyroidism. Myasthenia gravis is an autoimmune condition with an established association with autoimmune thyroid disease. We report the case of a patient who presented with recent onset unilateral ptosis that was fatigable with a history of proptosis since a year. On examination, she had a goiter, bilateral proptosis, restriction of upward gaze and adduction both eyes and normal pupils. Investigations revealed primary hypothyroidism with anti-thyroid peroxidase positive and anti-acetylcholine receptor antibody positive. Computerized tomography orbit showed thickening of medial and inferior rectus characteristic of thyroid orbitopathy. A diagnosis of primary hypothyroidism with thyroid orbitopathy with ocular myasthenia gravis was made. Patient is on Levothyroxine and anticholinesterase medications and is on follow-up. We present this case to highlight that the presence of ptosis in a patient with thyroid orbitopathy should alert the clinician to the possible coexistence of myasthenia gravis.

Selvan, Chitra; Dutta, Deep; Maisnam, Indira; Thukral, Anubhav; Chakraborthy, P. P.; Roy, Ajitesh; Arora, Rakesh; Dutta, Soumik; Baidya, Arjun; Ghosh, Sujoy; Mukhopadhyay, Satinath; Chowdhury, Subhankar

2013-01-01

75

Randomized trial of intravenous immunoglobulins versus prednisolone in Graves' ophthalmopathy  

PubMed Central

Glucocorticoids are usually given for management of Graves' ophthalmopathy (GO), but they may cause side effects. By comparison, intravenous administration of immunoglobulins resulted in clinical improvement and decreased antibody titres in a large number of autoimmune diseases. Therefore, a randomized trial was done, in which 19 patients with active GO were treated with a 20-week course of oral prednisolone (P, starting dose 100 mg/day), and 21 received 1 g immunoglobulin/kg body weight for 2 consecutive days every 3 weeks. The immunoglobulin course was repeated six times. Before and at the end (20 weeks) of immunomodulating therapy, ophthalmological investigation and quantitative magnetic resonance (MR) imaging were performed. A successful outcome was observed in 12 (63%) P-and in 13 (62%) immunoglobulin-treated patients. Overall, there were no marked differences in degree of improvement between the two groups. Responders to treatment in both groups showed improvements in proptosis (median from 24.5 to 21.5 mm; P < 0.005), visual acuity (from 0.6 to 0.85; P < 0.001), intraocular pressure (from 25 to 20 mmHg; P < 0.0001), lid aperture (from 14 to 12 mm; P < 0.01) and a decrease in eye muscle area (inferior, from 44 to 33 mm2; medial, from 43 to 34 mm2; both P < 0.0005). Among the immunoglobulin-treated patients, there was a marked decrease of thyroid antibody titres. Side effects were more frequent and severe during P than during immunoglobulin therapy. Thus, with respect to the above mentioned objective parameters, P and immunoglobulin appeared to be equally effective in treatment of active GO.

KAHALY, G; PITZ, S; MULLER-FORELL, W; HOMMEL, G

1996-01-01

76

Lysosome-Related Genes Are Regulated in the Orbital Fat of Patients with Graves' Ophthalmopathy  

Microsoft Academic Search

PURPOSE. The molecular mechanism involved in the hypertro- phy of the orbital fat in patients with Graves' ophthalmopathy or thyroid eye disease (TED) remains unclear. Comparison of genome-wide expression profiles may help in the search for the gene sets involved in TED. METHODS. Twenty-five orbital adipose tissue specimens were obtained, from which the RNA was isolated. Four of the tissue

Mei-Hsiu Chen; Shu-Lang Liao; Ming-Hong Chen; Pei-Ling Tsou; Mei-Ju Shih; Tien-Chun Chang; Lee-Ming Chuang

77

Immunohistology of eye muscle in idiopathic orbital inflammatory disease (pseudotumor), Grave's ophthalmopathy and healthy controls  

Microsoft Academic Search

Inflammatory orbital disease can be triggered by a variety of causes. Two such diseases are pseudotumor orbitae and Grave's ophthalmopathy, and both involve extraocular muscles during a quiet phase in these two diseases. Biopsies obtained from a previous pseudotumor orbitae showed complement deposits and increased expression of HLA class-I antigens in the intermuscular tissue. The biopsies from two out of

Timo Lenderink; Martine J. Jager; Jan-Anthonie Bruijn; Robert J. W. Keizer

1993-01-01

78

Prediction of thermal acoustic oscillations (TAOs) in the CLAES solid CO2/neon system  

NASA Technical Reports Server (NTRS)

Results are presented of a study initiated to investigate the possibility that the existence of thermal acoustic oscillations (TAOs) in the Cryogenic Limb Atmospheric Etalon Spectrometer (CLAES) neon plumbing system ground configuration could be the cause of higher-than-predicted heat rates measured during thermal ground testing. Tests were conducted between warm boundary temperatures ranging from 40 to 100 K, which simulated the actual test conditions of the CLAES CO2/neon system. TAOs were observed between 6 and 106 Torr, which agreed with the analytical predictions, and verified the possible existence of TAOs in the CLAES system during ground testing. The presence of TAOs was eventually confirmed in the CLAES system during a subsequent thermal test and were determined to have caused the higher heat rates measured during the prior thermal test.

Spradley, I. E.; Yuan, S. W. K.

1991-01-01

79

TAO-BIST: A Framework for Testability Analysis and Optimization of RTL Circuits for BIST  

Microsoft Academic Search

In this paper, we present TAO-BIST, a framework for test- ing register-transfer level (RTL) controller-datapath ci rcuits using built-in self-test (BIST). Conventional BIST techniques at the RTL generally introduce more testability hardware than is nece ssary, thereby causing unnecessary area, delay and power overheads. They have typically been applied to only application-specific in- tegrated circuits (ASICs). TAO-BIST adopts a three-phased

Srivaths Ravi; Niraj K. Jha; Ganesh Lakshminarayana

2000-01-01

80

TaO x -based resistive switching memories: prospective and challenges  

NASA Astrophysics Data System (ADS)

Resistive switching memories (RRAMs) are attractive for replacement of conventional flash in the future. Although different switching materials have been reported; however, low-current operated devices (<100 ?A) are necessary for productive RRAM applications. Therefore, TaO x is one of the prospective switching materials because of two stable phases of TaO2 and Ta2O5, which can also control the stable low- and high-resistance states. Long program/erase endurance and data retention at high temperature under low-current operation are also reported in published literature. So far, bilayered TaO x with inert electrodes (Pt and/or Ir) or single layer TaO x with semi-reactive electrodes (W and Ti/W or Ta/Pt) is proposed for real RRAM applications. It is found that the memory characteristics at current compliance (CC) of 80 ?A is acceptable for real application; however, data are becoming worst at CC of 10 ?A. Therefore, it is very challenging to reduce the operation current (few microampere) of the RRAM devices. This study investigates the switching mode, mechanism, and performance of low-current operated TaO x -based devices as compared to other RRAM devices. This topical review will not only help for application of TaO x -based nanoscale RRAM devices but also encourage researcher to overcome the challenges in the future production.

Prakash, Amit; Jana, Debanjan; Maikap, Siddheswar

2013-10-01

81

Growth of (Na, K, Li)(Nb, Ta)O 3 single crystals by solid state crystal growth  

Microsoft Academic Search

A single crystal of (Na, K, Li)(Nb, Ta)O3 has been grown for the first time by the solid state crystal growth process. A seed crystal of ?001?-oriented KTaO3 was embedded in a matrix of (Na, K, Li)(Nb, Ta)O3 powder, which was then densified by hot-pressing. During annealing of the hot-pressed sample, a single crystal of (Na, K, Li)(Nb, Ta)O3 of

John G. Fisher; Andreja Ben?an; Janez Bernard; Janez Holc; Marija Kosec; Sophie Vernay; Daniel Rytz

2007-01-01

82

Therapeutic use of mini-scleral lenses in a patient with Graves' ophthalmopathy.  

PubMed

Patients with Graves' ophthalmopathy can be very challenging to manage secondary to the complex nature of their disease presentation. Patients may present with a variety of ocular findings including: lid retraction, periorbital and lid swelling, chemosis, conjunctival hyperemia, proptosis, optic neuropathy, restrictive myopathy, exposure keratopathy and/or keratoconjunctivitis sicca. Mini-scleral and scleral lens designs have been important in the management of irregular and regular corneas, and in the therapy of ocular surface diseases. We present here the case of a 48-year-old Caucasian male who had been diagnosed with Graves' ophthalmopathy 13 years earlier. With significant ocular surface staining and over ten diopters of astigmatism, the patient had never been able to wear contact lenses comfortably. After being fit with the Mini-Scleral Design™ lenses, his vision improved to 20/25 OU, his ocular surface improved, and overall quality of vision increased. PMID:24646903

Harthan, Jennifer S

2014-01-01

83

Thyroid remnant radioiodine ablation in a case of concurrent thyroid carcinoma, Graves' disease, and thyroid ophthalmopathy.  

PubMed

High-dose I-131 thyroid remnant ablation postthyroidectomy for differentiated thyroid carcinoma is beneficial but the risk of visual complications including loss of vision in patients with coexisting Graves' ophthalmopathy is not well documented. We report the case of a 42-year-old man who presented for radioiodine ablation post total thyroidectomy for metastatic papillary carcinoma, who also had Graves' ophthalmopathy and juvenile onset glaucoma. Concurrent presence of all these conditions in the same patient is rarely encountered and this case demonstrates the challenge faced by the clinicians in balancing the benefits and risks of currently recommended management strategies for these conditions. There is a potential risk of visual complications with I-131 therapy in patients with Graves' disease as it can lead to development of or exacerbation of preexisting ophthalmopathy. The acute exacerbation is usually transient and preventable with prophylactic corticosteroids. However, the use of corticosteroids is associated with various complications including exacerbation of glaucoma as demonstrated in this patient. PMID:17581332

Mansberg, Robert

2007-07-01

84

TRATAMIENTO DE LA ENFERMEDAD DE GRAVES CON ANÁLOGOS DE LA SOMATOSTATINA: CASO CLÍNICO SOMATOSTATIN ANALOGUE TREATMENT IN GRAVES' OPHTHALMOPATHY: A CASE REPORT  

Microsoft Academic Search

Case report: The effect of a somatostatin analogue in a patient with Graves' ophthalmopathy is presen- ted, including data on the dose requirements and the results of therapy. Discussion: There are few effective options for the management of Graves' ophthalmopathy, a cell- mediated immune co-morbidity of thyroid disease. Somatostatin analogues inhibit lymphocyte prolife- ration and activation, and accumulate in the

COLOMA-GONZÁLEZ I; MENGUAL-VERDÚ E; DOMÍNGUEZ-ECRIBANO JR; HUESO-ABANCENS JR

85

The optimal range of RET mutations to be tested: European comments to the guidelines of the American Thyroid Association  

PubMed Central

In the 9th ETA-CRN Meeting (September 2009, Lisbon) some recommendations from the American Thyroid Association (ATA) guidelines for the management of medullary thyroid cancer (MTC) were discussed by an European Panel of Experts (EPE). Among the 12 ATA recommendations related to hereditary MTC and to the optimal range of RET mutations to be tested (recommendations 1-5 and 9-15), 7 were shared and 5 were not shared by the EPE. In the present paper, the related comments and suggestions will be reported and discussed.

2013-01-01

86

Pressure induced local disorder to order phase transition in TaO2F  

NASA Astrophysics Data System (ADS)

Raman scattering on nearly zero thermal expansion material cubic TaO2F was studied at ambient temperature and pressures up to 20 GPa. Optically silent ambient cubic phase exhibits broad, intense bands due to anionic disorder (O/F) in TaO2F which alters the local symmetry and hence allows first order Raman scattering. A reversible cubic to rhombohedral phase transition onsets around 0.8 GPa and completes at 4.4 GPa. Thus, cubic and rhombohedral phases coexist between 0.8 and 4.4 GPa and disorderless rhombohedral single phase occurs above 4.4 GPa.

Kamali, K.; Ravindran, T. R.

2014-04-01

87

An Autism Spectrum Disorder Susceptibility Gene, TAO2, is Important for Basal Dendrite Formation in the Neocortex  

PubMed Central

How neurons develop their morphology is an important question in neurobiology. Here we describe a novel pathway that specifically affects the formation of basal dendrites and axonal projections in cortical pyramidal neurons. We report that thousand-and-one-amino acid 2 (TAO2) kinase plays an essential role in dendrite morphogenesis. TAO2 down-regulation impairs basal dendrite formation in vivo without affecting apical dendrites. Moreover, TAO2 interacts with Neuropilin 1 (Npn1), a receptor protein that binds the secreted guidance cue Semaphorin 3A (Sema3A). TAO2 over-expression restores dendrite formation in cultured cortical neurons from Npn1Sema? mice, which express Npn1 receptors incapable of binding Sema3A. TAO2 over-expression also ameliorates the basal dendrite impairment resulting from Npn1 down-regulation in vivo. Finally, Sema3A and TAO2 modulate the formation of basal dendrites through the activation of the c-Jun N-Terminal Kinase (JNK). These results delineate a pathway whereby Sema3A and Npn1 transduce signals through TAO2 and JNK to regulate basal dendrite development in cortical neurons.

de Anda, Froylan Calderon; Rosario, Ana Lucia; Durak, Omer; Tran, Tracy; Graff, Johannes; Meletis, Konstantinos; Rei, Damien; Soda, Takahiro; Madabhushi, Ram; Ginty, David D.; Kolodkin, Alex L.; Tsai, Li-Huei

2014-01-01

88

Ocular Changes and Approaches of Ophthalmopathy in Basedow - Graves- Parry- Flajani Disease  

PubMed Central

ABSTRACT Basedow-Graves disease is an autoimmune condition with multiple local and systemic aspects. Among these, oculopathy has a major impact on patient's life from both functional and esthetic point of view. Basedow-Graves oculopathy requires an appropriate positive and differential diagnosis using clinical and imagistic approaches. Treatment is always required in moderate or severe forms and it begins with simple general points and continues with medical and surgical therapies. Current article stresses upon the most characteristic clinical signs of thyroidian ophthalmopathy and the required current therapeutic approaches.

SARACI, George; TRETA, Anamaria

2011-01-01

89

Management of Thyroid Peroxidase Antibody Euthyroid Women in Pregnancy: Comparison of the American Thyroid Association and the Endocrine Society Guidelines  

PubMed Central

The presence of thyroid autoantibodies is relatively high in women of childbearing age. There is evidence that positive thyroperoxidase antibody even in euthyroid women may increase the risk of spontaneous and recurrent pregnancy loss and preterm delivery. However, the evidence is not enough to justify recommendation on the screening of pregnant women for thyroid autoantibodies or LT4 supplementation for reducing maternal or fetal complications. In this paper we reviewed the related evidence and compared the new guidelines of the American Thyroid Association and Endocrine Society with respect to the screening and management of positive thyroperoxidase antibody in euthyroid pregnant women. As there was no major contradiction or disagreement between the two guidelines, either one of two guidelines may be used by clinicians for the appropriate management of thyroid autoimmunity during pregnancy.

Mehran, L.; Tohidi, M.; Sarvghadi, F.; Delshad, H.; Amouzegar, A.; Soldin, O. P.; Azizi, F.

2013-01-01

90

A genomic point mutation in the extracellular domain of the thyrotropin receptor in patients with Graves` ophthalmopathy  

Microsoft Academic Search

Orbital and pretibial fibroblasts are targets of autoimmune attack in Graves` ophthalmopathy (GO) and pretibial dermopathy (PTD). The fibroblast autoantigen involved in these peripheral manifestations of Graves` disease and the reason for the association of GO and PTD with hyperthyroidism are unknown. RNA encoding the full-length extracellular domain of the TSH receptor has been demonstrated in orbital and dermal fibroblasts

R. S. Bahn; C. M. Dutton; A. E. Heufelder; G. Sarkar

1994-01-01

91

77 FR 31036 - Notice of Availability of the Record of Decision for the Taos Resource Management Plan...  

Federal Register 2010, 2011, 2012, 2013

...DEPARTMENT OF THE INTERIOR Bureau of Land Management [LLNMF02000 L16100000.DT0000 LXSS026G0000...of Decision for the Taos Resource Management Plan/Environmental Impact Statement AGENCY: Bureau of Land Management, Interior. ACTION: Notice of...

2012-05-24

92

Two Early Gamma-ray Bursts Optical Afterglow Detections with TAOS Telescopes--GRB 071010B and GRB 071112C  

SciTech Connect

We present on two early detections of GRB afterglows with the Taiwanese-American Occltation Sruvey (TAOS) telescopes. The robotic TAOS system has been devised so that the routine Kuiper Belt Object (KBO) survey is interrupted when a GRB alert is triggered. Our first detection, GRB 071010B was detected by TAOS 62 s after the burst and showed a weak early brightening during the observations. No significant correction with the prompt gamma-ray emission indicated that our optical emission detected is afterglow emission. The second detection of TAOS, GRB 071112C was detected 96 s after the burst, also showed a possible initial raising then followed a steep decay in the R-band light curve.

Huang, K. Y.; Wang, S. Y. [Institute of Astronomy and Astrophysics, Academia Sinica, P.O. Box 23-141, Taipei 106, Taiwan (China); Urata, Y. [Dept. of Physics, Saitama University, Shimookubo, Saitama 338-8570 Japan (Japan); Institute of Astronomy and Astrophysics, Academia Sinica, P.O. Box 23-141, Taipei 106, Taiwan (China)

2009-05-25

93

Transcaruncular Medial Wall Orbital Decompression: An Effective Approach for Patients with Unilateral Graves Ophthalmopathy  

PubMed Central

Purpose. To evaluate the reduction in proptosis, incidence of postoperative diplopia, and postoperative globe symmetry after transcaruncular medial wall decompression in patients with unilateral Graves ophthalmopathy. Methods. Retrospective review of 16 consecutive patients who underwent unilateral transcaruncular medial wall orbital decompression from 1995 to 2007. The diagnosis of Graves ophthalmopathy was based on history and clinical findings including proptosis, lagophthalmos, lid retraction, motility restriction, and systemic thyroid dysfunction. Results. The mean reduction in proptosis was 2.3?mm. The mean difference in exophthalmometry preoperatively between the two eyes in each patient was 3.1?mm whereas postoperatively the mean difference was 1.1?mm (P = 0.0002). Eleven of 16 patients (69%) had 1?mm or less of asymmetry postoperatively. There was no statistically significant difference in the incidence of diplopia pre and postoperatively (P = 1.0). Conclusions. Medial wall orbital decompression is a safe and practical surgical approach for patients with unilateral Graves orbitopathy. The procedure carries a low risk of morbidity and yields anatomic retrusion of the globe that is comparable to other more invasive methods and may yield more symmetric postoperative results.

Hill, Robert H.; Czyz, Craig N.; Bersani, Thomas A.

2012-01-01

94

Clinical criteria for the assessment of disease activity in Graves' ophthalmopathy: a novel approach.  

PubMed Central

Patients with serious inflammatory Graves' ophthalmopathy should be treated with anti-inflammatory drugs or radiotherapy to prevent complications like fibrosis, while those with non-inflammatory ophthalmopathy may be treated by surgery immediately. It is often difficult, however, to distinguish inflammatory from non-inflammatory Graves' disease. We therefore present a simple clinical classification here to differentiate between these two conditions. This classification is based on the classical signs of inflammation--pain, redness, swelling, and impaired function. After two consecutive clinical examinations an 'activity score' can be determined, ranging from 0 to 10 points. In a retrospective study testing the efficacy of this classification we found that patients with an activity score of 3 or more at the beginning of therapy responded well to anti-inflammatory drugs, while those with a lower activity score mostly did not. Comparing the pretreatment activity score with the degree of enlargement of the extraocular muscles on the CT scan, we found a significant correlation between these two parameters: the higher the activity score, the more the enlargement of the muscles. We conclude that this classification facilitates the proper selection of patients for treatment. Images

Mourits, M P; Koornneef, L; Wiersinga, W M; Prummel, M F; Berghout, A; van der Gaag, R

1989-01-01

95

Curanderismo in Taos County, New Mexico--A Possible Case of Anthropological Romanticism?  

PubMed Central

Interviews with 25 Spanish-Americans of Taos County, New Mexico, indicate that time and acculturation have greatly eroded the belief in and practice of curanderismo, the traditional folk medical system of the Southwest. Curanderismo in northern New Mexico today has moved from being a primary and important source of medical care to one used alternatively and very occasionally in cases of pediatric disorders, chronic illnesses and pain, and for those maladies still classified according to the traditional folk beliefs.

Scheper-Hughes, Nancy; Stewart, David

1983-01-01

96

Adiponectin concentration in the orbital fat of patients with Graves' ophthalmopathy  

PubMed Central

Background “Graves’ ophthalmopathy” (GO), is an inflammatory disease of the orbit, with extensive adipose tissue involvement. Previous studies of orbital fat derived from such patients have demonstrated overexpression of the adiponectin gene and messenger RNA. Aim The study reported here aimed to measure the protein concentration of orbital adipose tissue adiponectin in GO patients, in comparison to healthy controls. Methods This was a prospective study. Orbital samples from ten healthy controls undergoing blepharoplasty and five patients with GO undergoing orbital fat decompression for proptosis were analyzed by enzyme-linked immunosorbent assay. Results The mean adiponectin concentration in samples from GO patients was 121.9 ± 29.5 ng/mL (mean ± standard deviation), versus 107.9 ± 26.6 ng/mL in the control group (P=0.20). Conclusion This study was unable to demonstrate a statistically significant difference in adiponectin protein concentrations between the two studied groups.

Soiberman, Uri; Levy, Ran; Leibovitch, Igal

2013-01-01

97

Prostaglandin E2 elicits a morphological change in cultured orbital fibroblasts from patients with Graves ophthalmopathy.  

PubMed Central

Fibroblasts derived from distinct anatomical regions appear to differ in regard to their behavior in culture. These differences may reflect functions of these cells in vivo that are tissue specific. Moreover, intrinsic differences in fibroblasts may underlie the site-specific connective tissue manifestations associated with systemic disease. We have demonstrated previously that orbital fibroblasts exhibit different cytokine response domains and protein synthetic programs when compared to those emanating from the skin. In the present communication, we demonstrate that prostaglandin E2 (PGE2) elicits in cultured human orbital fibroblasts from patients with Graves ophthalmopathy a rapid and dramatic change in cell morphology in vitro as assessed by phase-contrast and scanning electron microscopy. The central areas of the cells become elevated with respect to the plane of the substratum and are stellate, with long processes that touch neighboring cells. These changes occur within 6 hr of prostanoid addition to culture medium at an apparent concentration threshold of approximately 10 nM. Shape changes are accompanied by marked alterations in monolayer impedance as assessed by electric cell-substrate impedance sensing as described previously. Both morphologic and impedance changes elicited by PGE2 revert over 24 hr toward those found in untreated cells despite the continued presence of the prostanoid in the culture medium. In contrast, dermal fibroblasts fail to respond to PGE2. These observations define a previously unrecognized phenotypic attribute of orbital fibroblasts. Intrinsic differences in these cells may account for the anatomic site-selective vulnerability of the orbit in Graves ophthalmopathy. The culture system described here may be useful for studying the morphogenic actions of prostanoids. Images

Smith, T J; Wang, H S; Hogg, M G; Henrikson, R C; Keese, C R; Giaever, I

1994-01-01

98

Results of diplopia and strabismus in patients with severe thyroid ophthalmopathy after orbital decompression  

PubMed Central

Purpose: It has been frequently stated that the orbital decompression, in patients with thyroid ophthalmopathy, does not usually improve extraocular muscles function and that after the operation there is often a deterioration of these functions. The purpose of this article is evaluation of extraocular muscles function after applying personal method of 3 wall orbital decompression. Materials And Methods: Retrospective review of case records of 119 patients with severe thyroid ophthalmopathy seen and treated by the author between December 1986 and December 2010. All patents underwent 3 wall orbital decompression combined with removal of the periorbital, intraorbital and retrobulbar fat. Correction of coexistent eyelid retraction and deformities were also performed. Results: Comparison of preoperative and postoperative results was conducted in 65 patients three months after 3 wall decompression. All patients showed a significant reduction of exophthalmos [5-11 mm, 7.2 mm on average], reduction of intraocular pressure, marked improvement in ocular muscle function as well as considerable reduction in or disappearance of subjective symptoms. There were no cases of subsequent impairment of ocular motility. Strabismus surgery was performed in 6 patients with residual diplopia. There was an improvement in vision in 68% patients who had impaired vision before the operation. Less evident relapse of exophthalmos was recorded in 3 cases only and only one patient required unilateral reoperation. Conclusion: It can be concluded that this method of orbital decompression is logical, based on an understanding of the pathology, has less complication rates, is relatively easy to perform, gives very good functional and aesthetic long term results and allows rapid recovery.

Roncevic, Radmilo; Savkovic, Zorica; Roncevic, Dusan

2014-01-01

99

Iodine supplementation for pregnancy and lactation-United States and Canada: recommendations of the American Thyroid Association.  

PubMed

The fetus is totally dependent in early pregnancy on maternal thyroxine for normal brain development. Adequate maternal dietary intake of iodine during pregnancy is essential for maternal thyroxine production and later for thyroid function in the fetus. If iodine insufficiency leads to inadequate production of thyroid hormones and hypothyroidism during pregnancy, then irreversible fetal brain damage can result. In the United States, the median urinary iodine (UI) was 168 microg/L in 2001-2002, well within the range of normal established by the World Health Organization (WHO), but whereas the UI of pregnant women (173 microg/L; 95% CI 75-229 microg/L) was within the range recommended by WHO (150-249 microg/L), the lower 95% CI was less than 150 microg/L. Therefore, until additional physiologic data are available to make a better judgment, the American Thyroid Association recommends that women receive 150 microg iodine supplements daily during pregnancy and lactation and that all prenatal vitamin/mineral preparations contain 150 microg of iodine. PMID:17042677

Becker, David V; Braverman, Lewis E; Delange, François; Dunn, John T; Franklyn, Jayne A; Hollowell, Joseph G; Lamm, Steven H; Mitchell, Marvin L; Pearce, Elizabeth; Robbins, Jacob; Rovet, Joanne F

2006-10-01

100

Calcitonin estimation in patients with nodular goiter and its significance for early detection of MTC: european comments to the guidelines of the American Thyroid Association  

PubMed Central

One of the most discussed and controversial issue in the management of thyroid nodules is the need to perform a routine measurement of serum Calcitonin (Ct) in all cases. The American Thyroid Association guidelines do not recommend in favor or against this procedure since they retain that there are not enough evidences that it can determine an advantage to the health outcomes of these patients. This is not the view of many European experts who met in Lisbon in 2009 at the European Thyroid Association-Cancer Research Network meeting to discuss all the still open controversial issues on the management of medullary thyroid cancer patients. This paper is focused on the routine measurement of serum Ct in all patients with thyroid nodule(s): the evidences, the rational and the benefits of this procedure are deeply analysed following the discussion that was done in Lisbon. The conclusions reached at that time are reported in detail.

2013-01-01

101

Prevalence of Graves' ophthalmopathy in patients with Graves' disease presenting to a referral centre in north India  

PubMed Central

Background & objectives: The prevalence of Graves’ ophthalmopathy (GO) varies widely in different ethnic groups. Indians have been reported to have a lower prevalence of Graves’ ophthalmopathy as compared to Caucasians of European origin, but data are sparse and inconclusive. We studied the prevalence, clinical features and association of GO in Indian patients with Graves’ disease attending a referral centre in north India. Methods: A prospective study was conducted on 235 consecutive newly referred north Indian patients with Graves’ disease presenting to a tertiary care centre in north India. All patients underwent a comprehensive ophthalmological examination as per the European Group on Graves’ Orbitopathy (EUGOGO) recommendations. Results: GO was diagnosed in 65 patients (prevalence 28%; 95% confidence interval 22-33%). The prevalence was similar in males (28%) and females (27%). It was mild in 83 per cent, moderate-severe in 15 per cent and sight-threatening in only 2 per cent of cases. Ophthalmopathy was clinically active in only two (3%) cases. Upper eyelid retraction was the most common manifestation (83%), followed by exophthalmos (75%). Extra-ocular muscle involvement (5%) and optic nerve dysfunction (2%) were uncommon. The risk of GO was 3.9- fold (95% confidence interval 1.1-13.6) higher in smokers compared to non-smokers. However, severity of disease in smokers was similar to non-smokers. On multivariate logistic regression analysis, GO was associated only with high thyrotropin receptor antibody titres and current smoking. Interpretation & conclusions: Among north Indian patients with GD studied at a referral center, the prevalence of GO was similar to Caucasians of European descent, but clinically active and severe ophthalmopathy was uncommon. More studies are needed to confirm these findings.

Reddy, Sagili Vijaya Bhaskar; Jain, Anu; Yadav, Subhash B.; Sharma, Kumudini; Bhatia, Eesh

2014-01-01

102

Report on the Taos round table: Oil and money in the next decade  

SciTech Connect

This report summarizes the content of the conference held May 8--10, 1992 in Taos, Mexico. The conference explored the topic ``what is required from the world oil and gas community and what does it cost?`` The topics included areas of growth potential, changing demand patterns for refined product, and cost of pollution regulations. The conference then explored the requirements from the oil exploration and production sector, the requirements from the financial community and the priorities which should be set, and finally what strategy should be developed for survival growth and profitability in the next decade.

NONE

1992-12-31

103

UPLC-QTOF-MS with chemical profiling approach for rapidly evaluating chemical consistency between traditional and dispensing granule decoctions of Tao-Hong-Si-Wu decoction  

PubMed Central

Background In the present study, chemical consistency between traditional and dispensing granule decoctions of Tao-Hong-Si-Wu decoction was rapidly evaluated by UPLC-QTOF-MS coupled with the MarkerLynx software. Two different kinds of decoctions, namely traditional decoction: water extract of mixed six constituent herbs of Tao-Hong-Si-Wu decoction, and dispensing granules decoction: mixed water extract of each individual herbs of Tao-Hong-Si-Wu decoction, were prepared. Results Chemical difference was found between traditional and dispensing granule decoctions, and albiflorin, paeoniflorin, gallic acid, amygdalin, and hydroxysafflor yellow A were identified as the significantly changed components during decocting Tao-Hong-Si-Wu decoction. All the peaks of mass spectrum from Tao-Hong-Si-Wu decoction and each herb were extracted and integration by using QuanLynx™. And the optimized data was used for linear regression analysis. The contribution of each herb in Tao-Hong-Si-Wu decoction, and the optimal compatibility proportion of dispensing granule decoction were derived from the linear regression equation. Conclusions The optimal dosage proportionality of Tao-Hong-Si-Wu dispensing granule decoction was obtained as 2.5:0.2:1:0.5:0.6:0.1 (DG : CX : BS : SD : TR : HH), which guided better clinic application of Tao-Hong-Si-Wu decoction as dispensing granule decoctions usage, and it also provided some experimental data to reveal the compatibility rule of the relative TCM formulae.

2012-01-01

104

Case 3. "Jiang Tao v. Chengdu Branch, People's People's Bank of China": Opinion by the People's Court in Wuhou District, Chengdu, Sichuan Province  

ERIC Educational Resources Information Center

This article presents the decision of the People's Court in Wuhou District, Chengdu, Sichuan Province on the Jiang Tao v. Chengdu Branch, People's People's Bank of China case. Jiang Tao, the plaintiff, claimed that the defendant Chengdu Branch placed an announcement in the "Chengdu Business Daily" to "recruit tellers for Chengdu Branch" on…

Chinese Education and Society, 2006

2006-01-01

105

World Wide Web access to real-time and historical data from the TAO array of moored buoys in the tropical Pacific Ocean: updates for 1996  

Microsoft Academic Search

The TAO array consists of approximately 70 moored buoys in the tropical Pacific Ocean, telemetering data in real time via the Argos satellite. Supported by an international consortium, it is a major component of the global climate monitoring system. TAO data is readily available via the World Wide Web, Unix\\/X-windows\\/Internet, and anonymous FTP. Available data includes real time and historical

N. N. Soreide; D. C. McClurg; W. H. Zhu; M. J. McPhaden; D. W. Denbo; M. W. Renton

1996-01-01

106

Graves’ Ophthalmopathy  

Microsoft Academic Search

\\u000a Graves’ orbitopathy (GO) is one of the extrathyroidal manifestations of Graves’ disease. The incidence of GO apparently is\\u000a declining in the last few decades, likely as a result of a decreased prevalence of smoking and earlier diagnosis and treatment\\u000a of hyperthyroidism. Clinical presentation is typically that of a bilateral symmetric eye disease, but why GO is unilateral\\u000a or occurs in

Wilmar M. Wiersinga

1997-01-01

107

Should Graves' disease be considered a collagen disorder of the thyroid, skeletal muscle and connective tissue?  

PubMed

Graves' disease comprises hyperthyroidism, ophthalmopathy, pretibial myxedema and acropachy, which occur separately or in various combinations. We have used the indirect immunofluorescence test to investigate reactivity of sera from patients with autoimmune thyroid disorders with and without ophthalmopathy, with porcine extra ocular muscle (EOM) and control tissue substrates. Sera from 75% of patients with Graves' hyperthyroidism (GH) and ophthalmopathy, which we call thyroid-associated opthalmopathy (TAO), contained one or more antibodies reactive with EOM compared to 32% of those with GH without the eye disorder, 41% of patients with Hashimoto's thyroiditis (HT), and 16% of normals. Antibodies reactive with an EOM connective tissue antigen(s), seen as fluorescence of the interstitium and endomysium, were found in sera from 10% of patients with TAO and 16% of those with GH, but not from any patient with HT or normal subject. Similar patterns of connective tissue reactivity were also found in lacrimal gland, skeletal muscle, kidney and salivary gland. Antinuclear antibodies were detected in sera from 31% of patients with TAO, but from only 8% with HT, in no patient with GH and in only 3% of normal subjects. The most common pattern was a fine speckled fluorescence, found in 45% of sera, consistent with reactivity against the Sm antigen or nuclear RNP. The finding of a high prevalence of ANA and, less often, anti-connective tissue antibodies in patients with thyroid autoimmunity and ophthalmopathy, is consistent with Graves' disease being a "collagen-like disorder". The reason why inflammation and resulting tissue damage is limited to the thyroid, connective tissue of the skin and orbit, skeletal muscle and, possibly, the lacrimal gland, is unclear. One possibility is cross reaction of ANA with tissue specific membrane proteins in these sites. The extent of immunologic abnormalities, and the resulting clinical features, in patients with Graves' disease may reflect the severity of a putative defect in immune regulation. PMID:8750780

Kiljanski, J; Nebes, V; Stachura, I; Kennerdell, J S; Wall, J R

1995-12-01

108

Lithium ion conduction in A-site deficient perovskites R 1\\/4Li 1\\/4TaO 3 (R=La, Nd, Sm and Y)  

Microsoft Academic Search

New lithium ion conductors of perovskite-type compounds R1\\/4Li1\\/4TaO3 (R=La, Nd, Sm and Y) were synthesized, and their crystal structure and lithium ion conductivity were characterized. Symmetry of the perovskite lattice changed from cubic for La1\\/4Li1\\/4TaO3 to tetragonal for Nd1\\/4Li1\\/4TaO3 and Sm1\\/4Li1\\/4TaO3, and to orthorhombic for Y1\\/4Li1\\/4TaO3. The alternate ordering of R and Li ions and vacancies at the A-sites was

Katsuyoshi Mizumoto; Shinsuke Hayashi

1999-01-01

109

Paleomagnetism and tectonic interpretations of the Taos Plateau volcanic field, Rio Grande rift, New Mexico  

NASA Technical Reports Server (NTRS)

The tectonic response of the Taos Plateau volcanic field in the southern San Luis basin to late stage extensional environment of the Rio Grande rift was investigate using paleomagnetic techniques. Sixty-two sites (533 samples) of Pliocene volcanic units were collected covering four major rock types with ages of 4.7 to 1.8 Ma. Twenty-two of these sites were from stratigraphic sections of the lower, middle and upper Servilleta Basalt collected in the Rio Grande gorge at two locations 19 km apart. Flows from the lower and middle members in the southern gorge record reversed polarities, while those in Garapata Canyon are normal with an excursion event in the middle of the sequence. The uppermost flows of the upper member at both sites display normal directions. Although these sections correlate chemically, they seem to represent different magnetic time periods during the Gilbert Reversed-Polarity Chron. The data suggest the Taos Plateau volcanic field, showing no rotation and some flattening in the south and east, has acted as a stable buttress and has been downwarped by overriding of the southeastern end of the plateau by the Picuris Mountains, which make up the northern corner of the counter-clockwise rotating Espanola block.

Brown, Laurie L.; Caffall, Nancy M.; Golombek, Matthew P.

1993-01-01

110

Ground and space applications of TAOS (toolkit for analysis of optical systems)  

NASA Astrophysics Data System (ADS)

An integrated optics, controls, and structures modeling tool has been developed to analyze the performance of complex electro- optical (EO) sensing systems. Hosted within an object-oriented graphical environment (Khoros) developed by the University of New Mexico, complex systems such as active ground-based telescopes, airborne spectrometers, and space-based sparse array telescopes can be simulated and rapidly evaluated. The TAOS model integrates data products from existing codes such as MATLAB, CODE 5, NASTRAN, and others to allow multi-disiplinary parametric analysis of system performance. Because the model includes accurate physical optics and radiometric representations, almost any function of an optics system can be quickly generated and studied. In addition, degrading effects of dynamic structures, use of compensating control systems, and effects of the observing environment (wind load, boundary layer, and seeing) can also be included. Use of this simulation tool on NASA programs such as the Space Telescope Imaging Spectrometer has reduced design schedules by factors of three. Other typical analysis applications include the study of atmospheric compensated imaging systems using combined adaptive optics/post-processing techniques, simulation of hyper-spectral imagers, and methods for achieving coherent phasing of telescope arrays. This paper also provides a progress report on TAOS modeling of the European Southern Observatory (ESO) Very Large Telescope (VLT).

Tilley, James N.; Hagerty, Susan P.; Lieber, Michael D.; Peck, Cynthia S.

1994-07-01

111

TAOS: Taiwan-American Occultation Survey of Comet-Sized Objects in the Kuiper Belt  

NASA Technical Reports Server (NTRS)

Several dozen minor planets with radii greater than 100 km have been detected beyond Neptune using large telescopes. The TAOS project is to measure directly the number of these KBOs (Kuiper Belt Objects) down to the typical size of cometary nuclei (a few km) and out as far as approximately 100 AU from the Sun. Because of their large distance, small sizes and presumed low albedos, these target objects are extremely faint. Three 50 cm wide field robotic telescopes with 2048 x 2048 CCD cameras will be deployed along a 7 km east-west baseline in or near Jade Mountain National Park in Taiwan. They will monitor approximately 3000 stars for occultations by KBOs in a coincidence mode, so that the sequence and timing of the three separate blinkings can be used to distinguish real events from false alarms. Follow-up imaging observations using large telescopes will yield albedos and orbits for some of the larger objects detected by TAOS. A fourth telescope on a north-south spur to refine the size information on occulting GABON is also being contemplated.

Lissauer, Jack; DeVincenzi, Donald (Technical Monitor)

1999-01-01

112

Transconjunctival orbital decompression in Graves' ophthalmopathy: lateral wall approach ab interno  

PubMed Central

AIMS—A modified surgical technique is described to perform a one, two, or three wall orbital decompression in patients with Graves' ophthalmopathy.?METHODS—The lateral wall was approached ab interno through a "swinging eyelid" approach (lateral canthotomy and lower fornix incision) and an extended periosteum incision along the inferior and lateral orbital margin. In addition, the orbital floor and medial wall were removed when indicated. To minimise the incidence of iatrogenic diplopia, the lateral and medial walls were used as the first surfaces of decompression, leaving the "medial orbital strut" intact. During 1998, this technique was used in a consecutive series of 19 patients (35 orbits) with compressive optic neuropathy (six patients), severe exposure keratopathy (one patient), or disfiguring/congestive Graves' ophthalmopathy (12 patients).?RESULTS—The preoperative Hertel value (35 eyes) was on average 25 mm (range 19-31 mm). The mean proptosis reduction at 2 months after surgery was 5.5 mm (range 3-7 mm). Of the total group of 19 patients, iatrogenic diplopia occurred in two (12.5%) of 16 patients who had no preoperative diplopia or only when tired. The three other patients with continuous preoperative diplopia showed no improvement of double vision after orbital decompression, even when the ocular motility (ductions) had improved. In the total group, there was no significant change of ductions in any direction at 2 months after surgery. All six patients with recent onset compressive optic neuropathy showed improvement of visual acuity after surgery. No visual deterioration related to surgery was observed in this study. A high satisfaction score (mean 8.2 on a scale of 1 to 10) was noted following the operation.?CONCLUSION—This versatile procedure is safe and efficacious, patient and cost friendly. Advantages are the low incidence of induced diplopia and periorbital hypaesthesia, the hidden and small incision, the minimal surgical trauma to the temporalis muscle, and fast patient recovery. The main disadvantage is the limited exposure of the posterior medial and lateral wall.??

Paridaens, D.; Verhoeff, K.; Bouwens, D.; van den Bosch, W. A

2000-01-01

113

Increased microRNA-155 and decreased microRNA-146a may promote ocular inflammation and proliferation in Graves' ophthalmopathy.  

PubMed

Graves' ophthalmopathy is an inflammatory autoimmune disease of the orbit, characterized by inflammation and proliferation of the orbital tissue caused by CD4+T cells and orbital fibroblasts. Despite recent substantial findings regarding its cellular and molecular foundations, the pathogenesis of Graves' ophthalmopathy remains unclear. Accumulating data suggest that microRNAs play important roles in the pathophysiology of autoimmunity and proliferation. Specifically, microRNA-155 (miR-155) can promote autoimmune inflammation by enhancing inflammatory T cell development. In contrast to miR-155, microRNA-146a (miR-146a) can inhibit the immune response by suppressing T cell activation. Furthermore, miR-155 and miR-146a are involved in cell proliferation, differentiation, and many other life processes. Thus, miR-155 and miR-146a, with opposite impacts on inflammatory responses carried out by T lymphocytes, appear to have multiple targets in the pathogenesis of Graves' ophthalmopathy. Our previous work showed that the expression of miR-146a was significantly decreased in peripheral blood mononuclear cells from Graves' ophthalmopathy patients compared with normal subjects. Accordingly, we proposed that the expression of miR-155 increased and the expression of miR-146a decreased in the target cells (CD4+T cells and orbital fibroblasts), thus promoting ocular inflammation and proliferation in Graves' ophthalmopathy. The proposed hypothesis warrants further investigation of the function of the differentially expressed microRNAs, which may shed new light on the pathogenesis of Graves' ophthalmopathy and lead to new strategies for its management. PMID:24743332

Li, Kaijun; Du, Yi; Jiang, Ben-Li; He, Jian-Feng

2014-01-01

114

Increased microRNA-155 and decreased microRNA-146a may promote ocular inflammation and proliferation in Graves' ophthalmopathy  

PubMed Central

Graves’ ophthalmopathy is an inflammatory autoimmune disease of the orbit, characterized by inflammation and proliferation of the orbital tissue caused by CD4+T cells and orbital fibroblasts. Despite recent substantial findings regarding its cellular and molecular foundations, the pathogenesis of Graves’ ophthalmopathy remains unclear. Accumulating data suggest that microRNAs play important roles in the pathophysiology of autoimmunity and proliferation. Specifically, microRNA-155 (miR-155) can promote autoimmune inflammation by enhancing inflammatory T cell development. In contrast to miR-155, microRNA-146a (miR-146a) can inhibit the immune response by suppressing T cell activation. Furthermore, miR-155 and miR-146a are involved in cell proliferation, differentiation, and many other life processes. Thus, miR-155 and miR-146a, with opposite impacts on inflammatory responses carried out by T lymphocytes, appear to have multiple targets in the pathogenesis of Graves’ ophthalmopathy. Our previous work showed that the expression of miR-146a was significantly decreased in peripheral blood mononuclear cells from Graves’ ophthalmopathy patients compared with normal subjects. Accordingly, we proposed that the expression of miR-155 increased and the expression of miR-146a decreased in the target cells (CD4+T cells and orbital fibroblasts), thus promoting ocular inflammation and proliferation in Graves’ ophthalmopathy. The proposed hypothesis warrants further investigation of the function of the differentially expressed microRNAs, which may shed new light on the pathogenesis of Graves’ ophthalmopathy and lead to new strategies for its management.

Li, Kaijun; Du, Yi; Jiang, Ben-Li; He, Jian-Feng

2014-01-01

115

Broadband-gain Nd 3+-doped Ba(Zr, Mg, Ta)O 3 ceramic lasers for ultrashort pulse generation  

NASA Astrophysics Data System (ADS)

We report Nd 3+-doped Ba(Zr, Mg, Ta)O 3 ceramic lasers. The fluorescence of the ceramics shows characteristic broadband spectra due to the disordered crystalline system and can be tailored by the composition adjustment. The continuous-wave laser operations as well as the first mode-locked laser operation are presented.

Kurokawa, H.; Shirakawa, A.; Tokurakawa, M.; Ueda, K.; Kuretake, S.; Tanaka, N.; Kintaka, Y.; Kageyama, K.; Takagi, H.; Kaminskii, A. A.

2011-03-01

116

Bridging East and West--Or, a Bridge Too Far? Paulo Freire and the "Tao Te Ching"  

ERIC Educational Resources Information Center

This article considers key differences and similarities between Freirean and Taoist ideals. I limit my focus to the "Tao Te Ching" (attributed to Lao Tzu), paying brief attention to the origins of this classic work of Chinese philosophy before concentrating on several themes of relevance to Freire's work. An essay by James Fraser (1997), who makes…

Roberts, Peter

2012-01-01

117

Association of IL12B polymorphisms with susceptibility to Graves ophthalmopathy in a Taiwan Chinese population  

PubMed Central

Background Interleukin 12B (IL12B) gene polymorphisms have been linked to several inflammatory diseases, but their role in the development of Graves ophthalmopathy (GO) in Graves disease (GD) patients is unclear. The purpose of this study was to investigate the disease association of IL12B single nucleotide polymorphisms (SNPs). Methods A Taiwan Chinese population comprising 200 GD patients with GO and 271 GD patients without GO was genotyped using an allele-specific extension and ligation method. Hardy-Weinberg equilibrium was estimated using the chi-square test. Allele and genotype frequencies were compared between GD patients with and without GO using the chi-square test. Results The genotype and allele frequencies of examined SNPs did not differ between GD patients with and without GO. Although the genotype distribution remained nonsignificant in the sex-stratified analyses, the frequency of the T allele at SNP rs1003199 was significantly higher in patients with GO in the male cohort (P = 6.00 × 10-3). In addition, haplotypes of IL12B may be used to predict the risk of GO (P = 1.70 × 10-2); however, we could not prove the statistical significance of analysis after applying the Bonferroni correction. Conclusions Our results provide new information that the examined IL12B gene polymorphisms may be associated with susceptibility to GO in the Taiwan Chinese population in a sex-specific manner. This conclusion requires further investigation.

2012-01-01

118

Evidence for Enhanced Adipogenesis in the Orbits of Patients with Graves' Ophthalmopathy  

PubMed Central

The signs and symptoms of Graves’ ophthalmopathy (GO) result from increased volume of the orbital contents, including adipose, connective, and extraocular muscle tissues. We wanted to determine whether the expanded adipose tissue volume might be in part attributable to de novo adipogenesis. We measured levels of mRNA encoding leptin, adiponectin, peroxisome proliferator-activated receptor ? (PPAR?), preadipocyte factor-1, and TSH receptor (TSHr) genes in orbital adipose tissues from GO patients (n = 22) and normal individuals (n = 18) and in orbital preadipocyte cultures derived from GO patients (n = 6) and normal subjects (n = 3) using quantitative real-time RT PCR. We found increased leptin, adiponectin, PPAR?, and TSHr expression in GO compared with normal orbital tissue samples, with positive correlations in the GO tissues between TSHr and leptin, adiponectin and PPAR?. In vitro differentiation of GO and normal preadipocytes resulted in enhanced adiponectin, leptin, and TSHr expression, with greater expression of the latter two genes in the GO cultures. These results suggest that de novo adipogenesis within orbital tissues with parallel enhanced expression of TSHr may be important in the pathogenesis of GO, and that potential therapies for GO might include inhibition of the adipogenic pathway.

KUMAR, SEEMA; COENEN, MICHAEL J.; SCHERER, PHILIPP E.; BAHN, REBECCA S.

2014-01-01

119

Disease activity in Graves' ophthalmopathy: diagnosis with orbital MR imaging and correlation with clinical score.  

PubMed

In Graves' ophthalmopathy (GO) it is important to distinguish acute inflammation at an early stage, responsive to immunosuppressive treatment, from inactive fibrotic end stage disease, unresponsive to the same treatment. The purpose of this study was to identify the most relevant signal intensities on orbital MR imaging with contrast administration both to classify patients according to their clinical activity score (defined by a cut-off value of 3) and to make a prediction of patient's CAS. Such threshold was considered as widely used in literature. Sixteen consecutive patients with a diagnosis of GO in different phases of thyroid disease based on clinical and orbital MR imaging signs, and six normal volunteers were examined. Orbital MR imaging was performed on a 1.5 Tesla MR Unit. MR scans were assessed by an experienced neuroradiologist, blinded to the clinical examinations. We found a statistical correlation between CAS and both STIR and contrast enhanced T1-weighted sequences. There was also a statistically significant correlation between STIR and contrast-enhanced T1 images disclosing the possibility of avoiding the injection of contrast medium. Our study proved that signal intensity values on STIR sequence increase in the inflammatory oedematous phase of disease. We confirmed the correlation between signal intensities on this sequence and CAS, showing an increase in signal intensity proportional to the CAS value. So we validated MRI use to establish the activity phase of disease more sensitively than CAS alone. PMID:24199816

Tortora, Fabio; Cirillo, Mario; Ferrara, Marco; Belfiore, Maria Paola; Carella, Carlo; Caranci, Ferdinando; Cirillo, Sossio

2013-10-01

120

Rhizome of Anemarrhena asphodeloides counteracts diabetic ophthalmopathy progression in streptozotocin-induced diabetic rats.  

PubMed

Diabetic ophthalmopathy (DO) impairs patients' eyesight and even causes blindness. Here, we investigated the effect of 60% ethanol extract of the rhizome of Anemarrhenae asphodeloides (ERA), which is commonly used in Chinese medicine formulae in treating diabetes, on DO progression. Blood glucose, insulin, advanced glycation end products (AGE), super oxygen dehydrogenises (SOD), malondialdehyde (MDA) and glutathione peroxidase (GSH-Px) levels in serum and sorbitol concentration in the lens were measured. Retinal endothelium/pericyte (E/P) ratio was evaluated, and structural changes of the retina and lens were observed. Effects of mangiferin and neomangiferin, the two major components of ERA, on subnormal growth of pericytes induced by high glucose were also detected. It was found that the activities of SOD and GSH-Px in serum were increased, whereas MDA and AGE levels in serum and sorbitol concentration in the lens were decreased in ERA-treated DO rats. E/P ratio was decreased, and the pathological changes of the lens and retina were alleviated by ERA treatment. Moreover, the subnormal growth of pericytes induced by high glucose was ameliorated by mangiferin and neomangiferin. These results indicated that ERA could effectively prevent DO progression in streptozotocin-induced diabetic rats, and mangiferin and neomangiferin may be the main effective components. PMID:23148017

Li, Xuan; Cui, Xiaobing; Wang, Jinjin; Yang, Jie; Sun, Xiaoyu; Li, Xiaodong; Zhu, Quan; Li, Wei

2013-08-01

121

Differential Involvement of Orbital Fat and Extraocular Muscles in Graves' Ophthalmopathy  

PubMed Central

Graves' ophthalmopathy (GO) is characterized by swelling of orbital fat and extraocular muscles, but little attention has been given to differential involvement of fat and muscles. Advancements in imaging allow rather accurate measurements of orbital bony cavity volume (OV), fat volume (FV) and muscle volume (MV), and are the topics of this review. Ratios of FV/OV and MV/OV neutralize gender differences. In adult Caucasian controls, mean values ± SD of FV/OV are 0.56 ± 0.11 and of MV/OV are 0.15 ± 0.02. FV increases substantially and MV decreases slightly with advancing age, requiring age-specific reference ranges. In 95 consecutive untreated Caucasian GO patients, both FV and MV were within normal limits in 25%, increased FV but normal MV was present in 5%, normal FV but increased MV was detected in 61%, and both increased FV and MV was evident in 9%. Increased FV was associated with more proptosis and longer GO duration. Increased MV was associated with older age, more severe GO (more proptosis and diplopia, worse eye muscle ductions), higher TBII and current smoking. At the cellular and molecular level differential involvement of fat and muscles might be related to differences between fibroblast phenotypes and cytokine profiles in each compartment, to different orbital T cell subsets during the course of the disease and to peroxisome proliferator activator receptor-? polymorphisms and modulation of 11?-hydroxysteroid dehydrogenase-1. Enlarged muscles are apparently a rather early phenomenon in GO, whereas increases in fat mass occur relatively late. Why a minor subset of GO patients presents with an increase of only fat remains poorly understood.

Wiersinga, Wilmar M.; Regensburg, Noortje I.; Mourits, Maarten P.

2013-01-01

122

A prospective, randomized trial of intravenous glucocorticoids therapy with different protocols for patients with graves' ophthalmopathy.  

PubMed

Background: For patients with active moderate-to-severe Graves' ophthalmopathy (GO), a course of 4.5 g iv glucocorticoids (GCs) is the recommended therapy. The weekly protocol is preferred because of the potential safety concerns with the daily protocol. However, evidence for the superiority of different administration protocols is lacking. Methods: We conducted a prospective, randomized trial to compare the efficacy and safety of two protocols of iv 4.5 g methylprednisolone in a total of 80 patients in our institute. The patients were randomized to receive iv methylprednisolone weekly or daily. The response rate (a composite response endpoint including lid width, soft tissue involvement, proptosis, intraocular pressure, Clinical Activity Score [CAS], diplopia, and visual acuity) was evaluated as the primary outcome, and adverse effects were recorded at each visit. GO-associated serum cytokines were measured. Results: We found a significantly greater response rate for the weekly protocol vs the daily protocol at the 12th week (76.92 vs 41.03%; P = .0025) and a similar response rate at the fourth week. Seven patients on the daily protocol worsened when tapering iv methylprednisolone to oral prednisone in the fourth week. Patients in both groups showed significant CAS response, and at the 12th week, patients on the weekly protocol showed a nonsignificant trend toward greater CAS response. Weekly protocol showed significant prolonged retreatment-free survival. Severe side effects were only observed in two cases, both of which were on the daily protocol. Furthermore, we observed sustained decreased levels of serum CXCL10 in the 12th week compared to the baseline level (P = .0009) in the patients on the weekly protocol. Conclusions: The weekly protocol of iv methylprednisolone therapy is more efficient and safer than the daily protocol for patients with active moderate-to-severe GO. PMID:24606088

Zhu, Wei; Ye, Lei; Shen, Liyun; Jiao, Qin; Huang, Fengjiao; Han, Rulai; Zhang, Xiaofang; Wang, Shu; Wang, Weiqing; Ning, Guang

2014-06-01

123

[Peripheral blood cell factors of Graves ophthalmopathy and effect of intervention with tripterygium glycosides].  

PubMed

To explore the effect of tripterygium glycosides on the level of peripheral blood cell factors of Graves ophthalmopathy (GO). In the study, 64 patients of GO in moderate-severe acute stage were selected, and randomly divided into the treatment group (32 cases) and the control group (32 cases). Both of the two groups were provided with basic treatment. The control group was added with prednisone(0. 75 mg kg-1 d-1 ), which gradually reduced (by 5-10 mg week-1 )to the minimum dose of 5 mg d-1. The treatment group was treated with 20 mg tripterygium glycosides, three times a day. One therapy course is three months. The levels of peripheral blood cells(TNF-alpha , IL-2, IL-10, IFN-gamma)of the two groups before and after the treatment and the clinical efficacy were observed. The study indicated that, before the treatment, TNF-alpha, IL-2, IFN-gamma in both groups were significantly higher than that in the health group, but with IL-10 notably lower than the healthy group. After the treatment, TNF-a, IL-2, IFN-gamma in the treatment group significantly decreased, but with IL-10 significantly increasing (P <0. 01). After the treatment, the two groups showed significant difference (P <0. 01). The total clinical efficacy in the treatment group was 88. 10% , and that in the control group was 57. 14% (P <0. 01). After the treatment, the two groups showed significant changes in the exophthalmos degree (P < 0. 01). The results showed that the level of peripheral blood cells (TNF-alpha,IL-2, IL-10, IFN-gamma)of GO patients was positively correlated with the severity of ocular disease. The combined therapy of tripterygium glycosides and methimazole show such advantages as low side effect and high clin- PMID:24946565

Xu, Jian-Ping; Xu, Jian-Ping; Xu, Chen; Chen, Jun; Jin, Zhi-Hua; Zheng, Hong-Fei; Zhu, Jun

2014-02-01

124

Differential involvement of orbital fat and extraocular muscles in graves' ophthalmopathy.  

PubMed

Graves' ophthalmopathy (GO) is characterized by swelling of orbital fat and extraocular muscles, but little attention has been given to differential involvement of fat and muscles. Advancements in imaging allow rather accurate measurements of orbital bony cavity volume (OV), fat volume (FV) and muscle volume (MV), and are the topics of this review. Ratios of FV/OV and MV/OV neutralize gender differences. In adult Caucasian controls, mean values ± SD of FV/OV are 0.56 ± 0.11 and of MV/OV are 0.15 ± 0.02. FV increases substantially and MV decreases slightly with advancing age, requiring age-specific reference ranges. In 95 consecutive untreated Caucasian GO patients, both FV and MV were within normal limits in 25%, increased FV but normal MV was present in 5%, normal FV but increased MV was detected in 61%, and both increased FV and MV was evident in 9%. Increased FV was associated with more proptosis and longer GO duration. Increased MV was associated with older age, more severe GO (more proptosis and diplopia, worse eye muscle ductions), higher TBII and current smoking. At the cellular and molecular level differential involvement of fat and muscles might be related to differences between fibroblast phenotypes and cytokine profiles in each compartment, to different orbital T cell subsets during the course of the disease and to peroxisome proliferator activator receptor-? polymorphisms and modulation of 11?-hydroxysteroid dehydrogenase-1. Enlarged muscles are apparently a rather early phenomenon in GO, whereas increases in fat mass occur relatively late. Why a minor subset of GO patients presents with an increase of only fat remains poorly understood. PMID:24783034

Wiersinga, Wilmar M; Regensburg, Noortje I; Mourits, Maarten P

2013-03-01

125

Structural Characterization of New Layered Perovskites MLa 2Ti 2TaO 10 ( M=Cs, Rb) and NaLa 2Ti 2TaO 10 · xH 2O ( x=2, 0.9, 0)  

Microsoft Academic Search

The crystal structures of n=3 Dion–Jacobson phases MLa2Ti2TaO10 (M=Cs, Rb) and NaLa2Ti2TaO10 ·xH2O (x=2, 0.9, 0) have been investigated by the Rietveld analysis of their powder XRD patterns. These compounds show the new-type ordering sequence of (Ti1\\/2Ta1\\/2)O6–TiO6–(Ti1\\/2Ta1\\/2)O6 in the tripled octahedra, corresponding to the niobium analogs of MLa2Ti2NbO10. They crystallize in the tetragonal system P4\\/mmm with lattice constants of a=3.84733(9)

Young-Sik Hong; Chi-Hwan Han; Keon Kim

2001-01-01

126

Molecular cloning and characterization of genes for antibodies generated by orbital tissue-infiltrating B-cells in Graves` ophthalmopathy  

SciTech Connect

Graves` ophthalmopathy is a distressing autoimmune disease of unknown etiology. Analysis of the genes for antibodies secreted by orbital tissue-infiltrating plasma cells might provide insight into the pathogenesis of this disease. The authors, therefore, constructed an immunoglobulin heavy (H) chain and an immunoglobulin k light (L) chain cDNA library from the orbital tissue of a patient with active Graves` ophthalmopathy. Analysis of 15 H (IgG1) and 15 L (k) chains revealed a restricted spectrum of variable region genes. Fourteen of 15 variable k genes were about 94% homologous to the closest known germline gene, KL012. Thirteen of 15 H chain genes were 91% and 90% homologous to the closest germline genes, DP10 and hv1263, respectively. Remarkably, these germline genes also code for other autoantibodies to striated muscle (KL012) and thyroid peridase (KL012 and hv1263). These studies raise the possibility that particular germline genes may be associated with autoimmunity in humans. Further, the present study opens the way to identifying ocular autoantigens that may be the target of an humoral immune response. 29 refs., 4 figs., 1 tab.

Jaume, J.C.; Portolano, S.; Prummel, M.F.; McLachlan, S.M.; Rapoport, B. [Univ. of California, San Francisco, CA (United States)] [Univ. of California, San Francisco, CA (United States)

1994-02-01

127

Pirfenidone attenuates IL-1?-induced COX-2 and PGE2 production in orbital fibroblasts through suppression of NF-?B activity.  

PubMed

The aim of this study was to determine the effect of pirfenidone on interleukin (IL)-1?-induced cyclooxygenase (COX)-2 and prostaglandin (PG)E2 expression in orbital fibroblasts from patients with thyroid-associated ophthalmopathy (TAO). Primary cultures of orbital fibroblasts from patients with TAO (n = 4) and non-TAO subjects (n = 4) were prepared. The level of PGE2 in orbital fibroblasts treated with IL-1? in the presence or absence of pirfenidone was measured using an enzyme-linked immunosorbent assay. The effect of pirfenidone on IL-1?-induced COX-2 expression in orbital fibroblasts from patients with TAO was evaluated by reverse transcription-polymerase chain reaction (PCR) and quantitative real-time PCR analyses, and verified by Western blot. Activation of nuclear factor-?B (NF-?B) was evaluated by immunoblotting for inhibitor of ?B (I?B)? and phosphorylated I?B?, and DNA-binding activity of p50/p65 NF-?B was analyzed by electrophoretic mobility shift assay. In addition, IL-1 receptor type 1 (IL-1R1) expression was assessed by RT-PCR in IL-1?-treated cells with or without pirfenidone. Pirfenidone significantly attenuated IL-1?-induced PGE2 release in both TAO and non-TAO cells. IL-1?-induced COX-2 mRNA and protein expression decreased significantly following co-treatment with pirfenidone. IL-1?-induced I?B? phosphorylation and degradation decreased in the presence of pirfenidone and led to decreased nuclear translocation and DNA binding of the active NF-?B complex. In our system, neither IL-1? nor pirfenidone co-treatment influenced IL-1R1 expression. Our results suggest that pirfenidone attenuates the IL-1?-induced PGE2/COX-2 production in TAO orbital fibroblasts, which is related with suppression of the NF-?B activation. PMID:23664858

Choi, Youn-Hee; Back, Keum Ok; Kim, Hee Ja; Lee, Sang Yeul; Kook, Koung Hoon

2013-08-01

128

Geologic map of the Sunshine 7.5' quadrangle, Taos County, New Mexico  

USGS Publications Warehouse

The Sunshine 7.5' quadrangle is located in the south-central part of the San Luis Basin of northern New Mexico, in the Rio Grande del Norte National Monument, and contains deposits that record volcanic, tectonic, and associated alluvial and colluvial processes over the past four million years. Sunshine Valley, named for the small locale of Sunshine, is incised by a series of northeast-trending drainages cut into Tertiary and Quaternary alluvial deposits forming an extensive alluvial apron between the east flank of the Sangre de Cristo Mountains and the Rio Grande. These deposits predominantly overlie gently eastward-dipping lava flows of Pliocene Servilleta Basalt erupted from centers west of the map area. Servilleta Basalt lava flows terminate to the south against the elevated topography of three volcanic centers of the Taos Plateau volcanic field. From west to east these are Cerro de la Olla, Cerro Chiflo, and Guadalupe Mountain that are exposed in the southern part of the map area. Remnants of Miocene volcanic rocks are exposed near the southwestern edge of the map area and record evidence of an eroded volcanic terrain underlying deposits of the Taos Plateau volcanic field. These deposits are likely fault bounded to the east, roughly coincident with north to northwest trending, down-to-east faults in the southwestern quarter of the map area. The down-to-east normal faults reflect the basinward migration of the western margin of the Sunshine Valley sub-basin of the southern San Luis Basin. Pliocene and younger basin deposition was accommodated along predominantly north-trending fault-bounded grabens and is preserved as poorly exposed fault scarps that cut lava flows of Ute Mountain volcano, north of the map area. The Servilleta Basalt and younger surficial deposits record largely down-to-east basinward displacement. Faults are identified with varying confidence levels in the map area. Recognizing and mapping faults developed near the surface in relatively young, brittle volcanic rocks is difficult because: (1) they tend to form fractured zones tens of meters wide rather than discrete fault planes, (2) the relative youth of the deposits has resulted in only modest displacements on most faults, and (3) some of the faults may have significant strike-slip components that do not result in large vertical offsets that are readily apparent in offset of sub-horizontal contacts. Those faults characterized as “certain” either have distinct offset of map units or had slip planes that were directly observed in the field. Lineaments defined from magnetic anomalies form an additional constraint on potential fault locations.

Thompson, Ren A.; Turner, Kenzie J.; Shroba, Ralph R.; Cosca, Michael A.; Ruleman, Chester A.; Lee, John P.; Brandt, Theodore R.

2014-01-01

129

MiniTAO/MAX38 first light: 30-micron band observations from the ground-based telescope  

NASA Astrophysics Data System (ADS)

We successfully carried out 30-micron observations from the ground-based telescope for the first time with our newly developed mid-infrared instrument, MAX38, which is mounted on the University of Tokyo Atacama 1.0-m telescope (miniTAO telescope). Thanks to the high altitude of the miniTAO (5,640m) and dry weather condition of the Atacama site, we can access the 30-micron wavelength region from ground-based telescopes. To achieve the observation at 30- micron wavelength, remarkable devices are employed in MAX38. First, a Si:Sb 128x128 array detector is installed which can detect long mid-infrared light up to 38-micron. Second, we developed metal mesh filters for 30-micron region band-pass filter, which are composed of several gold thin-films with cross-shaped holes. Third, a cold chopper, a 6-cm square plane mirror controlled by a piezoelectric actuator, is built into the MAX38 optics for canceling out the atmospheric turbulence noise. It enables square-wave chopping with a 50-arcsecound throw at a frequency more than 5- Hz. Finally, a low-dispersion grism spectrometer (R~50) will provide information on the transmission spectrum of the terrestrial atmosphere in 20 to 40 micron. In this observation, we clearly demonstrated that the atmospheric windows around 30-micron can be used for the astronomical observations at the miniTAO site.

Nakamura, Tomohiko; Miyata, Takashi; Sako, Shigeyuki; Asano, Kentaro; Uchiyama, Mizuho; Tanabe, Toshihiko; Yoneda, Mizuki; Ita, Yoshifusa; Onaka, Takashi; Kataza, Hirokazu; Aoki, Tsutomu; Doi, Mamoru; Handa, Toshihiro; Kato, Daisuke; Kawara, Kimiaki; Kohno, Kotaro; Konishi, Masahiro; Koshida, Shintaro; Minezaki, Takeo; Mitani, Natsuko; Motohara, Kentaro; Ohsawa, Ryo; Soyano, Takao; Tanaka, Masuo; Tarusawa, Ken'ichi; Toshikawa, Koji; Yoshii, Yuzuru

2010-07-01

130

Orbital positron emission tomography/computed tomography (PET/CT) imaging findings in graves ophthalmopathy  

PubMed Central

Background We aimed to describe orbital positron emission tomography/computed tomography (PET/CT) imaging findings, both structural and metabolic, in different clinical stages of Graves ophthalmopathy (GO). This prospective, observational, cross-sectional study examined 32 eyes of 16 patients with GO. Methods Patients were assessed with a complete ophthalmological evaluation and assigned a VISA classification for GO. All patients underwent serum thyroid hormone measurement, antibody profile, and 18-fluorodeoxyglucose positron emission tomography/computed tomography (18-FDG PET/CT) of the orbits. The 18-FDG uptake on PET images was expressed in terms of maximum standard uptake value (SUVmax). CT images were analyzed, and orbital structures were measured in millimeters. Vision, inflammation, strabismus, and overall appearance were assessed according to the VISA classification system, thyroid hormone levels, antibody values, 18-FDG uptake, and thickness of orbital structures. Results Altogether, 32 eyes of 16 patients (10 women, 6 men; mean age 44.31?±?13 years, range 20–71 years) were included. Three patients were hypothyroid, seven were euthyroid, and six were hyperthyroid. CT measurements of extraocular muscle diameter were elevated (P??0.05). Conclusions We demonstrated a lack of correlation between 18-FDG extraocular muscle uptake and either clinical inflammation score or muscle diameter. Although 18-FDG uptake has been used as an inflammation marker in other pathologies, inflammation in GO may be clinically detected in PET/CT-negative cases, and cases with negative clinical findings may show inflammation on PET/CT. Clinical evaluation is mandatory but may be insufficient and inaccurate for classifying GO. A larger and homogeneous sample size and further research is needed to define the role of PET/CT in detecting, grading, and follow-up of GO to optimize treatment of the inflammatory stage respect clinical methods currently used.

2013-01-01

131

Spontaneous hemorrhage from orbital cavernous hemangioma resulting in sudden onset of ophthalmopathy in an adult--case report.  

PubMed

A 61-year-old woman presented with a very rare case of spontaneous bleeding from an orbital cavernous hemangioma manifesting as sudden onset of ophthalmic pain, proptosis, diplopia, and nausea. Magnetic resonance (MR) imaging and computed tomography (CT) revealed an intraconal, well-demarcated cystic mass with hemorrhage. The mass was immediately removed through a transcranial approach. Histological examination showed that the mass was a cavernous hemangioma. Ophthalmopathy was resolved by surgery. Orbital cavernous hemangioma is very common in adults, but spontaneous bleeding is extremely rare relative to intracranial cavernous hemangiomas. This rare case emphasizes the importance of careful neuroimaging evaluation with MR imaging and CT for diagnosing orbital cavernous hemangioma associated with spontaneous bleeding. PMID:23095267

Yamamoto, Junkoh; Takahashi, Mayu; Nakano, Yoshiteru; Saito, Takeshi; Kitagawa, Takehiro; Ueta, Kunihiro; Miyaoka, Ryo; Nishizawa, Shigeru

2012-01-01

132

Mid-infrared Monitoring Observations of Circumstellar Disks with TAO/MIMIZUKU  

NASA Astrophysics Data System (ADS)

Mid-infrared variabilities of dust continuum and features in time scale of days to years have been found in circumstellar disks around YSOs and debris disks by multi-epoch studies with recent space missions such as AKARI, WISE, Spitzer, and Herschel (e.g., Dahm+09, Espaillat+11, Flaherty+12, Melis+12). However, physical mechanisms leading to the rapid MIR variabilities are still unclear because of sparse data sampling. More frequent and long-term observations with ground-based MIR instruments are required. Meanwhile, fast fluctuation of atmospheric water vapor affects photometric accuracy in the MIR observations from the ground. In order to monitor the variabilities of a few percent level as detected by the space telescopes, improvements of observation methods are needed. We have been developing a new MIR instrument MIMIZUKU (Kamizuka+12, Miyata+10) mounted on 6.5-m TAO telescope (Yoshii+10), which will be constructed at a 5,640-m altitude site in Atacama, Chile, and 8.2-m Subaru telescope in Hawaii. The MIMIZUKU has unique equipment called Field Stacker which enables simultaneous observations of target and reference objects owing to focusing two separated field-of-views on a same detector. The simultaneity improves the photometric accuracy and realizes stable long-term monitoring. We will carry out MIR monitoring observations of dust emission from the circumstellar disks and the debris disks with the imaging and low-resolution spectroscopic modes of the MIMIZUKU. The time-variable emissions from the YSOs could allow us to reveal formation and destruction mechanism of dust grains in the inner disk region. In observations of debris disks, fresh dust formed by large collisions in a planetary disk is expected to be detected.

Sako, Shigeyuki; Miyata, Takashi; Kamizuka, Takafumi; Nakamura, Tomohiko; Asano, Kentaro; Uchiyama, Mizuho; Okada, Kazushi; Onaka, Takashi; Sakon, Itsuki; Kataza, Hirokazu; Yoshii, Yuzuru

2013-07-01

133

LG based decision aid for naval tactical action officer's (TAO) workstation  

NASA Astrophysics Data System (ADS)

In the increasingly NetCentric battlespace of the 21st century, Stilman Advanced Strategies Linguistic Geometry software has the potential to revolutionize the way that the Navy fights in two key areas: as a Tactical Decision Aid and for creating a relevant Common Operating Picture. Incorporating STILMAN's software into a prototype Tactical Action Officers (TAO) workstation as a Tactical Decision Aid (TDA) will allow warfighters to manage their assets more intelligently and effectively. This prototype workstation will be developed using human-centered design principles and will be an open, component-based architecture for combat control systems for future small surface combatants. It will integrate both uninhabited vehicles and onboard sensors and weapon systems across a squadron of small surface combatants. In addition, the hypergame representation of complex operations provides a paradigm for the presentation of a common operating picture to operators and personnel throughout the command hierarchy. In the hypergame technology there are game levels that span the range from the tactical to the global strategy level, with each level informing the others. This same principle will be applied to presenting the relevant common operating picture to operators. Each operator will receive a common operating picture that is appropriate for their level in the command hierarchy. The area covered by this operating picture and the level of detail contained within it will be dependent upon the specific tasks the operator is performing (supervisory vice tactical control) and the level of the operator (or command personnel) within the command hierarchy. Each level will inform the others to keep the picture concurrent and up-to-date.

Stilman, Boris; Yakhnis, Vladimir; Umanskiy, Oleg; Boyd, Ron

2005-05-01

134

Stop Codon in the Procollagen II Gene (COL2A1) in a Family with the Stickler Syndrome (Arthro-Ophthalmopathy)  

Microsoft Academic Search

Linkage analysis with restriction fragment length polymorphisms for the gene for type II procollagen (COL2A1) was carried out in a family with the Stickler syndrome, or arthro-ophthalmopathy, an autosomal dominant disorder that affects the eyes, ears, joints, and skeleton. The analysis demonstrated linkage of the disease and COL2A1 with a logarithm-of-odds score of 1.51 at zero recombination. A newly developed

Nilofer Nina Ahmad; Leena Ala-Kokko; Robert G. Knowlton; Sergio A. Jimenez; Eric J. Weaver; Joseph I. Maguire; William Tasman; Darwin J. Prockop

1991-01-01

135

Upper Limits on the Number of Small Bodies in Sedna-Like Orbits by the TAOS Project  

SciTech Connect

We present the results of a search for occultation events by objects at distances between 100 and 1000 AU in lightcurves from the Taiwanese-American Occultation Survey (TAOS). We searched for consecutive, shallow flux reductions in the stellar lightcurves obtained by our survey between 7 February 2005 and 31 December 2006 with a total of {approx} 4.5 x 10{sup 9} three-telescope simultaneous photometric measurements. No events were detected, allowing us to set upper limits on the number density as a function of size and distance of objects in Sedna-like orbits, using simple models.

Wang, J; Lehner, M J; Zhang, Z; Bianco, F B; Alcock, C; Chen, W; Axelrod, T; Byun, Y; Coehlo, N K; Cook, K H; Dave, R; de Pater, L; Porrata, R; Kim, D; King, S; Lee, T; Lin, H; Lissauer, J J; Marshall, S L; Protopapas, P; Rice, J A; Schwamb, M E; Wang, S; Wen, C

2009-11-13

136

2013 European Thyroid Association Guidelines for Cervical Ultrasound Scan and Ultrasound-Guided Techniques in the Postoperative Management of Patients with Thyroid Cancer  

PubMed Central

Cervical ultrasound scanning (US) is considered a key examination, by all major thyroid and endocrine specialist societies for the postoperative follow-up of thyroid cancer patients to assess the risk of recurrence. Neck US imaging is readily available, non-invasive, relatively easy to perform, cost-effective, and can guide diagnostic and therapeutic procedures with low complication rates. Its main shortcoming is its operator-dependency. Because of the pivotal role of US in the care of thyroid cancer patients, the European Thyroid Association convened a panel of international experts to review technical aspects, indications, results, and limitations of cervical US in the initial staging and follow-up of thyroid cancer patients. The main aim is to establish guidelines for both a cervical US scanning protocol and US-guided diagnostic and therapeutic procedures in patients with thyroid cancer. This report presents (1) standardization of the US scanning procedure, techniques of US-guided fine-needle aspiration, and reporting of findings; (2) definition of criteria for classification of malignancy risk based on cervical US imaging characteristics of neck masses and lymph nodes; (3) indications for US-guided fine-needle aspiration and for biological in situ assessments; (4) proposal of an algorithm for the follow-up of thyroid cancer patients based on risk stratification following histopathological and cervical US findings, and (5) discussion of the potential use of US-guided localization and ablation techniques for locoregional thyroid metastases.

Leenhardt, L.; Erdogan, M.F.; Hegedus, L.; Mandel, S.J.; Paschke, R.; Rago, T.; Russ, G.

2013-01-01

137

Introducing the reporting system for thyroid fine-needle aspiration cytology according to the new guidelines of the Japan Thyroid Association [Review].  

PubMed

The Japan Thyroid Association (JTA) recently published new guidelines for clinical management of thyroid nodules. This paper introduces their diagnostic system for reporting thyroid fine-needle aspiration cytology. There are two points where the new reporting system that differs from existing internationally-accepted ones. The first is the subclassification of the so-called indeterminate category, which is divided into 'follicular neoplasm' and 'others'. The second is the subclassification of follicular neoplasm into 'favor benign', 'borderline' and 'favor malignant'. It is characterized by self-explanatory terminologies as to histological type and probability of malignancy to establish further risk stratification as well as to facilitate communication between clinicians and cytopathologists. The different treatment strategies adopted for thyroid nodules is deeply influenced by the particular diagnostic system used for thyroid cytology. In Western countries all patients with follicular neoplasms are advised to have immediate diagnostic surgery while patients in Japan often undergo further risk stratification without immediate surgery. The JTA diagnostic system of reporting thyroid cytology is designed for further risk stratification of patients with indeterminate cytology. If a surgeon applies diagnostic lobectomy to all patients with follicular neoplasm unselectively, this subclassification of follicular neoplasm has no practical meaning and is unnecessary. Cytological risk stratification of follicular neoplasms is optional and cytopathologists can choose either a simple 6-tier system without stratification of follicular neoplasm or a complicated 8-tier system depending on their experience in thyroid cytology and clinical management. PMID:24727657

Kakudo, Kennichi; Kameyama, Kaori; Miyauchi, Akira; Nakamura, Hirotoshi

2014-06-29

138

Migration, Mental Frustration, and Modernity: The Social Origins of the Mental Disorders of the Tao Aboriginal People on Taiwan's Orchid Island  

Microsoft Academic Search

From the perspective of social suffering, the paper explores the correlation between the migration experience of the Tao aboriginal people on Taiwan's Orchid Island and their mental disorders examines the limits of the genetic approach to aboriginal health based on the biomedical model of medicine after the 1990s. The focus of the study is on the cases of mental disorder

Yu-Yueh Tsai

2007-01-01

139

Usefulness of TAO model to predict and manage the transformation in soil of carbon and nitrogen forms from West-Africa urban solid wastes  

Microsoft Academic Search

The TAO model of Transformation of Added Organic materials (AOM) calibrated on AOMs and substrates of temperate areas was used to assess the transformations in soil of carbon and nitrogen forms of AOMs: raw materials, selected mixtures and composts from Ouagadougou urban wastes. AOMs were studied in terms of chemical and biochemical contents and for their C and N mineralization

W. T. Kaboré; M. Pansu; E. Hien; S. Houot; N. P. Zombré; D. Masse

2011-01-01

140

Arsenic Removal from Drinking Water by Adsorptive Media - U.S. EPA Demonstration Project at Taos, NM, Final Performance Evaluation Report  

EPA Science Inventory

This report documents the activities performed and the results obtained for the EPA arsenic removal technology demonstration project at the Town of Taos in New Mexico. The main objective of the project was to evaluate the effectiveness of Severn Trent Services? (STS) SORB 33? ad...

141

Phase relationships in the BaO-Ga2O3-Ta2O5 system and the structure of Ba6Ga21TaO40.  

PubMed

Phase relationships in the BaO-Ga(2)O(3)-Ta(2)O(5) ternary system at 1200 °C were determined. The A(6)B(10)O(30) tetragonal tungsten bronze (TTB) related solution in the BaO-Ta(2)O(5) subsystem dissolved up to ~11 mol % Ga(2)O(3), forming a ternary trapezoid-shaped TTB-related solid solution region defined by the BaTa(2)O(6), Ba(1.1)Ta(5)O(13.6), Ba(1.58)Ga(0.92)Ta(4.08)O(13.16), and Ba(6)GaTa(9)O(30) compositions in the BaO-Ga(2)O(3)-Ta(2)O(5) system. Two ternary phases Ba(6)Ga(21)TaO(40) and eight-layer twinned hexagonal perovskite solid solution Ba(8)Ga(4-x)Ta(4+0.6x)O(24) were confirmed in the BaO-Ga(2)O(3)-Ta(2)O(5) system. Ba(6)Ga(21)TaO(40) crystallized in a monoclinic cell of a = 15.9130(2) Å, b = 11.7309(1) Å, c = 5.13593(6) Å, ? = 107.7893(9)°, and Z = 1 in space group C2/m. The structure of Ba(6)Ga(21)TaO(40) was solved by the charge flipping method, and it represents a three-dimensional (3D) mixed GaO(4) tetrahedral and GaO(6)/TaO(6) octahedral framework, forming mixed 1D 5/6-fold tunnels that accommodate the Ba cations along the c axis. The electrical property of Ba(6)Ga(21)TaO(40) was characterized by using ac impedance spectroscopy. PMID:22734887

Cao, Jiang; Yu, Xiaodi; Kuang, Xiaojun; Su, Qiang

2012-07-16

142

A genomic point mutation in the extracellular domain of the thyrotropin receptor in patients with Graves` ophthalmopathy  

SciTech Connect

Orbital and pretibial fibroblasts are targets of autoimmune attack in Graves` ophthalmopathy (GO) and pretibial dermopathy (PTD). The fibroblast autoantigen involved in these peripheral manifestations of Graves` disease and the reason for the association of GO and PTD with hyperthyroidism are unknown. RNA encoding the full-length extracellular domain of the TSH receptor has been demonstrated in orbital and dermal fibroblasts from patients with GO and normal subjects, suggesting a possible antigenic link between fibroblasts and thyrocytes. RNA was isolated from cultured orbital, pretibial, and abdominal fibroblasts obtained from patients with severe GO (n = 22) and normal subjects (n = 5). RNA was reverse transcribed, and the resulting cDNA was amplified by the polymerase chain reaction, using primers spanning overlapping regions of the entire extracellular domain of the TSH receptor. Nucleotide sequence analysis showed an A for C substitution in the first position of codon 52 in 2 of the patients, both of whom had GO, PTD, and acropachy. Genomic DNA isolated from the 2 affected patients, and not from an additional 12 normal subjects, revealed the codon 52 mutation by direct sequencing and AciI restriction enzyme digestions. In conclusion, the authors have demonstrated the presence of a genomic point mutation, leading to a threonine for proline amino acid shift in the predicted peptide, in the extracellular domain of the TSH receptor in two patients with severe GO, PTD, acropachy, and high thyroid-stimulating immunoglobulin levels. RNA encoding this mutant product was demonstrated in the fibroblasts of these patients. They suggest that the TSH receptor may be an important fibroblast autoantigen in GO and PTD, and that this mutant form of the receptor may have unique immunogenic properties. 28 refs., 3 figs., 2 tabs.

Bahn, R.S.; Dutton, C.M.; Heufelder, A.E.; Sarkar, G. [Mayo Clinic/Foundation, Rochester, MN (United States)] [Mayo Clinic/Foundation, Rochester, MN (United States); [Ludwig-Maximilians-Universitat, Munich (Germany)

1994-02-01

143

A genomic point mutation in the extracellular domain of the thyrotropin receptor in patients with Graves' ophthalmopathy.  

PubMed

Orbital and pretibial fibroblasts are targets of autoimmune attack in Graves' ophthalmopathy (GO) and pretibial dermopathy (PTD). The fibroblast autoantigen involved in these peripheral manifestations of Graves' disease and the reason for the association of GO and PTD with hyperthyroidism are unknown. RNA encoding the full-length extracellular domain of the TSH receptor has been demonstrated in orbital and dermal fibroblasts from patients with GO and normal subjects, suggesting a possible antigenic link between fibroblasts and thyrocytes. RNA was isolated from cultured orbital, pretibial, and abdominal fibroblasts obtained from patients with severe GO (n = 22) and normal subjects (n = 5). RNA was reverse transcribed, and the resulting cDNA was amplified by the polymerase chain reaction, using primers spanning overlapping regions of the entire extracellular domain of the TSH receptor. Nucleotide sequence analysis showed an A for C substitution in the first position of codon 52 in 2 of the patients, both of whom had GO, PTD, and acropachy. Genomic DNA isolated from the 2 affected patients, and not from an additional 12 normal subjects, revealed the codon 52 mutation by direct sequencing and AciI restriction enzyme digestions. In conclusion, we have demonstrated the presence of a genomic point mutation, leading to a threonine for proline amino acid shift in the predicted peptide, in the extracellular domain of the TSH receptor in two patients with severe GO, PTD, acropachy, and high thyroid-stimulating immunoglobulin levels. RNA encoding this mutant product was demonstrated in the fibroblasts of these patients. We suggest that the TSH receptor may be an important fibroblast autoantigen in GO and PTD, and that this mutant form of the receptor may have unique immunogenic properties. PMID:7508946

Bahn, R S; Dutton, C M; Heufelder, A E; Sarkar, G

1994-02-01

144

Association of BTG2, CYR61, ZFP36, and SCD Gene Polymorphisms with Graves' Disease and Ophthalmopathy.  

PubMed

Background: Environmental and genetic factors predispose an individual to the development of Graves' disease (GD). In an expression study of intraorbital tissue, adipocyte-related immediate early genes (IEGs) and immunomodulatory genes were found to be overexpressed in patients with Graves' ophthalmopathy (GO). We hypothesized that genetic variations in these genes could be associated with GD and/or GO. Methods: A total of 98 single nucleotide polymorphisms (SNPs) in 12 genes were genotyped in 594 GD patients with (n=267) or without (n=327) GO and 1147 sex- and ethnicity-matched controls from Malmö, Sweden. Results: Ten SNPs in four genes (BTG family, member 2 [BTG2], cysteine-rich, angiogenic inducer 61 [CYR61], zinc finger protein 36, C3H type, homolog mouse [ZFP36], and stearoyl-coenzyme A desaturase [SCD]) showed an association with GD and/or GO. SNPs rs12136280 (odds ratio [OR] 1.29, p=0.002), rs6663606 (OR 1.26, p=0.004), and rs17534202 (OR 1.21, p=0.02) in BTG2 and rs3753793 (OR 1.21, p=0.03) in CYR61 were associated with GD. An association with GO was shown for SNPs rs3753793 (OR 1.45, p=0.008), rs6682848 (OR 1.55, p=0.03), rs12756618 (OR 1.77, p=0.049), and rs1378228 (OR 1.29, p=0.049) in CYR61, rs1057745 (OR 1.56, p=0.03) and rs11083522 (OR 1.32, p=0.04) in ZFP36, and rs1393491 (OR 1.38, p=0,048) in SCD. Smoking and CYR61 rs12756618 interacted to increase the risk of GO. Conclusions: We found associations of SNPs in IEGs and SCD with GD and/or GO; however, confirmation in a different population is required. PMID:24780075

Planck, Tereza; Shahida, Bushra; Sjögren, Marketa; Groop, Leif; Hallengren, Bengt; Lantz, Mikael

2014-07-01

145

Displacement of Ta-O bonds near polymorphic phase transition in Li-, Ta-, and Sb-modified (K, Na)NbO3 ceramics  

NASA Astrophysics Data System (ADS)

Excellent piezoelectric properties can be obtained near the polymorphic phase transition (PPT) region in (K, Na)NbO3 based piezoceramics. The enhanced piezoelectric properties resulted from the 18-fold spontaneous polarization directions caused by the coexistence of orthorhombic and tetragonal phases. In this study, the various polarization directions derived from frequently changing Ta-O bonds in Li-, Ta-, and Sb-modified (K, Na)NbO3 ceramic were directly observed by extended X-ray absorption fine structure. More than three peaks were observed and represented the nearest neighbor Ta-O bonds because of the coexistence of tetragonal and orthorhombic phases as well as Ta displacements along the [001]c and [110]c directions. Hence, the domains rotated easily and responded actively to an external electric or force field. Large Pr and optimized piezoelectric properties were obtained near the PPT region.

Huan, Yu; Wang, Xiaohui; Li, Longtu

2014-06-01

146

Spred1 and TESK1Two New Interaction Partners of the Kinase MARKK\\/TAO1 That Link the Microtubule and Actin Cytoskeleton  

Microsoft Academic Search

ABSTRACT The signaling from MARKK\\/TAO1 to MARK\\/Par1 to phosphorylated MAPs renders microtubules dynamic,and plays a role in neurite outgrowth or polarity development. Since hyperphosphorylation of Tau at,MARK target sites is a hallmark of Alzheimer neurodegeneration we ,searched ,for upstream ,regulators by the ,yeast two-hybrid approach and identified two new interaction partners of MARKK, the regulator protein Spred1 and the kinase

Cindy Johne; Dorthe Matenia; Xiao-yu Li; Thomas Timm; Kiruthiga Balusamy; Eva-Maria Mandelkow

2008-01-01

147

The Permian–Triassic boundary at Nhi Tao, Vietnam: Evidence for recurrent influx of sulfidic watermasses to a shallow-marine carbonate platform  

Microsoft Academic Search

The Permian–Triassic boundary at Nhi Tao, Cao Bang Province, Vietnam was sampled in a 7.5-m-thick outcrop section at high resolution (?5 cm intervals) for chemostratigraphic and magnetic susceptibility analysis. The section consists entirely of slightly argillaceous limestone representing shallow-marine facies of the Jinxi Platform, one of several large carbonate platforms within the Nanpanjiang Basin, located on the southern margin of the

Thomas J. Algeo; Brooks Ellwood; Thi Kim Thoa Nguyen; Harry Rowe; J. Barry Maynard

2007-01-01

148

Changes in electronic structure upon lithium insertion reaction into the A-site deficient perovskite type oxides, Gd 1\\/3TaO 3  

Microsoft Academic Search

In this paper, the second of a two-part paper, results obtained by ab anitio calculation for the investigation on the electronic structure of electrochemically lithiated perovskite oxides LixGd1\\/3TaO3 are presented. From the results of ab initio calculation based on density functional theory, it was confirmed that tantalum and oxygen formed a covalent bond, while the electronic orbital gadolinium and lithium

Masanobu Nakayama; Kazuomi Imaki; Yoshiharu Uchimoto; Masataka Wakihara

2004-01-01

149

Changes in electronic structure upon lithium insertion reaction into the A-site-deficient perovskite-type oxides, Gd 1\\/3TaO 3  

Microsoft Academic Search

Electrochemical behavior and the variation of electronic structure upon lithium insertion into the A-site-deficient perovskite oxide, Gd1\\/3TaO3, have been studied by X-ray absorption spectroscopy (XAS). During electrochemical lithium insertion, Gd LIII-edge and Ta LI-edge XAS revealed that Gd ion did not contribute the charge compensation, while Ta ion reduced its oxidation state. Furthermore, the changes in O K-edge spectra with

Kazuomi Imaki; Masanobu Nakayama; Yoshiharu Uchimoto; Masataka Wakihara

2004-01-01

150

The epidemiologic characteristics and clinical course of ophthalmopathy associated with autoimmune thyroid disease in Olmsted County, Minnesota.  

PubMed Central

Among incident cases of GO in Olmsted County, Minnesota: GO affected females six times more frequently than males (86% versus 14% of cases, respectively). The age-adjusted incidence rate was 16 cases per 100,000 population per year for females and 2.9 cases per 100,000 population for males. The peak incidence rates were bimodal, occurring in the age groups 40 to 44 years and 60 to 64 years in females and 45 to 49 years and 65 to 69 years in males. Among patients with GO, approximately 90% had Graves' hyperthyroidism, 1% had primary hypothyroidism, 3% had Hashimoto's thyroiditis, and 5% were euthyroid. Eyelid retraction was the most common ophthalmic feature of autoimmune thyroid disease, being present either unilaterally or bilaterally in more than 90% of patients at some point in their clinical course. Exophthalmos of one or both eyes affected approximately 60% of patients, restrictive extraocular myopathy was apparent in about 40% of patients, and optic nerve dysfunction occurred in either one or both eyes in 6% of patients with autoimmune thyroid disease. Only 5% of patients had the complete constellation of classic findings: eyelid retraction, exophthalmos, optic nerve dysfunction, extraocular muscle involvement, and hyperthyroidism. Upper eyelid retraction, either unilateral or bilateral, was documented in approximately 75% of patients at the time of diagnosis of GO. Lid lag also was a frequent early sign, being present either unilaterally or bilaterally in 50% of patients at the initial examination. At the time of diagnosis of GO, the most frequent ocular symptom was pain or discomfort, which affected 30% of patients. Some degree of diplopia was noted by approximately 17% of patients, lacrimation or photophobia was present in about 15% to 20% of patients, and 7.5% of patients complained of blurred vision. Decreased vision attributable to optic neuropathy was present in less than 2% of eyes at the time of diagnosis of GO. Thyroid dermopathy and acropachy accompanied GO in approximately 4% and 1% of patients, respectively. Myasthenia gravis occurred in less than 1% of patients. Superior limbic keratoconjunctivitis was documented in less than 4% of patients. The median age at the time of diagnosis of GO was 43 years (range, 8 to 88). Among patients with hyperthyroidism, 61% developed ophthalmopathy within 1 year of the onset of thyrotoxicosis. Symptoms and signs for which statistically significant changes occurred between the initial and final examinations included lacrimation, pain or ocular discomfort, photophobia, eyelid retraction, lid lag, eyelid fullness, conjunctival injection, chemosis, and exophthalmos.(ABSTRACT TRUNCATED AT 400 WORDS) Images FIGURE 1 FIGURE 2 FIGURE 3

Bartley, G B

1994-01-01

151

The epidemiologic characteristics and clinical course of ophthalmopathy associated with autoimmune thyroid disease in Olmsted County, Minnesota.  

PubMed

Among incident cases of GO in Olmsted County, Minnesota: GO affected females six times more frequently than males (86% versus 14% of cases, respectively). The age-adjusted incidence rate was 16 cases per 100,000 population per year for females and 2.9 cases per 100,000 population for males. The peak incidence rates were bimodal, occurring in the age groups 40 to 44 years and 60 to 64 years in females and 45 to 49 years and 65 to 69 years in males. Among patients with GO, approximately 90% had Graves' hyperthyroidism, 1% had primary hypothyroidism, 3% had Hashimoto's thyroiditis, and 5% were euthyroid. Eyelid retraction was the most common ophthalmic feature of autoimmune thyroid disease, being present either unilaterally or bilaterally in more than 90% of patients at some point in their clinical course. Exophthalmos of one or both eyes affected approximately 60% of patients, restrictive extraocular myopathy was apparent in about 40% of patients, and optic nerve dysfunction occurred in either one or both eyes in 6% of patients with autoimmune thyroid disease. Only 5% of patients had the complete constellation of classic findings: eyelid retraction, exophthalmos, optic nerve dysfunction, extraocular muscle involvement, and hyperthyroidism. Upper eyelid retraction, either unilateral or bilateral, was documented in approximately 75% of patients at the time of diagnosis of GO. Lid lag also was a frequent early sign, being present either unilaterally or bilaterally in 50% of patients at the initial examination. At the time of diagnosis of GO, the most frequent ocular symptom was pain or discomfort, which affected 30% of patients. Some degree of diplopia was noted by approximately 17% of patients, lacrimation or photophobia was present in about 15% to 20% of patients, and 7.5% of patients complained of blurred vision. Decreased vision attributable to optic neuropathy was present in less than 2% of eyes at the time of diagnosis of GO. Thyroid dermopathy and acropachy accompanied GO in approximately 4% and 1% of patients, respectively. Myasthenia gravis occurred in less than 1% of patients. Superior limbic keratoconjunctivitis was documented in less than 4% of patients. The median age at the time of diagnosis of GO was 43 years (range, 8 to 88). Among patients with hyperthyroidism, 61% developed ophthalmopathy within 1 year of the onset of thyrotoxicosis. Symptoms and signs for which statistically significant changes occurred between the initial and final examinations included lacrimation, pain or ocular discomfort, photophobia, eyelid retraction, lid lag, eyelid fullness, conjunctival injection, chemosis, and exophthalmos.(ABSTRACT TRUNCATED AT 400 WORDS) PMID:7886878

Bartley, G B

1994-01-01

152

The protective effect of antioxidants on orbital fibroblasts from patients with Graves' ophthalmopathy in response to oxidative stress  

PubMed Central

Purpose: To investigate the biphasic effects of hydrogen peroxide (H2O2) on the orbital fibroblasts of patients with Graves’ ophthalmopathy (GO) and the relation to antioxidants and proinflammatory cytokines. Methods Proliferation of cultured orbital fibroblasts from patients with GO and normal controls was evaluated in response to various concentrations of H2O2. The effect of low concentrations of H2O2 (6.25 ?M) on the cellular proliferation and induction of intracellular proinflammatory cytokines, and reactive oxygen species of orbital fibroblasts were assessed. Protective effects of N-acetylcysteine and vitamin C on GO fibroblasts in response to 6.25 ?M H2O2 stimulation were also investigated. Results When the GO fibroblasts were exposed to H2O2 at a concentration of 50 ?M or above, significant cytotoxicity was observed. In contrast, lower concentrations of H2O2 (3.125–25 ?M) increased the survival of GO fibroblasts with the peak cellular proliferation at 6.25 ?M H2O2. However, this biphasic effect of H2O2 on the viability of orbital fibroblasts was not found in normal controls. In addition, 6.25 ?M H2O2 led to significant elevation of the levels of transforming growth factor, beta 1, interleukin-1?, and superoxide anion in GO fibroblasts, but no significant change in the normal controls. Pretreatment with N-acetylcysteine or vitamin C reversed the enhanced proliferation capacity and the induction of transforming growth factor, beta 1, interleukin-1? and superoxide anion of GO fibroblasts in response to 6.25 ?M H2O2. Conclusions These findings revealed the biphasic effect of H2O2 on cellular proliferation of GO orbital fibroblasts. Importantly, a low level of H2O2 can stimulate proliferation of GO orbital fibroblasts and induce the production of proinflammatory cytokines, which can be inhibited by pretreatment with antioxidants. This provides a theoretical basis for the rational use of antioxidant in treating GO at an early stage.

Tsai, Chieh-Chih; Wu, Shi-Bei; Kao, Shu-Ching; Kau, Hui-Chuan; Lee, Fenq-Lih

2013-01-01

153

Hypoxia increases adipogenesis and affects adipocytokine production in orbital fibroblasts-a possible explanation of the link between smoking and Graves' ophthalmopathy  

PubMed Central

AIM To assess the effects of hypoxia on human orbital fibroblasts (OF) on adipogenesis and adipocytokine production. METHODS Human OF were derived from tissues obtained from patients with Graves' ophthalmopathy (GO) and from patients without known thyroid diseases undergoing blepharoplasty. The OF were cultured separately under normoxic and hypoxic conditions. Comparisons of adipocytokine concentrations using multiplex ELISA and lipid accumulation in the cells using Oil Red O staining were subsequently performed. RESULTS There was increased adipogenesis in OF from GO subject when exposed to hypoxic culture conditions. This was not observed in OF from normal controls. Hypoxia led to an increase in leptin and a decrease in MCP-1 secretion in OF cultures. CONCLUSION Hypoxia induces adipogenesis in OF and may represent a mechanism by which smoking contributes to deterioration of GO. We also found novel changes to leptin and MCP-1 production in OF cultures exposed to hypoxia suggesting important roles of these cytokines in the disease process.

Chng, Chiaw Ling; Lai, Oi Fah; Chew, Charmaine Sze-Min; Peh, Yu Pei; Fook-Chong, Stephanie Man-Chung; Seah, Lay Leng; Khoo, Daphne Hsu-Chin

2014-01-01

154

The influence of hepatitis C infection and interferon-? therapy on thyrotropin blocking and stimulating autoantibodies in Graves' ophthalmopathy: a case report  

PubMed Central

Background Hepatitis C virus is a highly immunogenic pathogen often inducing autoimmune activation changes and this can often be further exacerbated by Interferon therapy. As HCV is lymphocytotropic, it can modulate T cell and B cell antibody responses, affecting many endocrine organs, most commonly the thyroid. Case presentation We hereby describe a case of fluctuating and wavering thyrotropin autoantibodies of both stimulating and blocking nature in the setting of Graves's ophthalmopathy, hepatitis C infection and interferon-?, causing hypo- and subsequently hyper-thyroidism. The autoantibody profile was clearly modified during interferon therapy and settled into a new equilibrium at the completion of treatment. Conclusion The case highlights the possible existence of a dual thyroid autoantibody population associated with hepatitis C, and its modulation by interferon therapy, which further compounds the difficulties in the assessment thyroid disease in this setting.

2009-01-01

155

Thyrotropin Regulates IL-6 Expression in CD34+ Fibrocytes: Clear Delineation of Its cAMP-Independent Actions  

PubMed Central

IL-6 plays diverse roles in normal and disease-associated immunity such as that associated with Graves’ disease (GD). In that syndrome, the orbit undergoes remodeling during a process known as thyroid-associated ophthalmopathy (TAO). Recently, CD34+ fibrocytes were found to infiltrate the orbit in TAO where they transition into CD34+ orbital fibroblasts. Surprisingly, fibrocytes display high levels of functional thyrotropin receptor (TSHR), the central antigen in GD. We report here that TSH and the pathogenic anti-TSHR antibodies that drive hyperthyroidism in GD induce IL-6 expression in fibrocytes and orbital fibroblasts. Unlike TSHR signaling in thyroid epithelium, that occurring in fibrocytes is completely independent of adenylate cyclase activation and cAMP generation. Instead TSH activates PDK1 and both AKT/PKB and PKC pathways. Expression and use of PKC?II switches to that of PKCµ as fibrocytes transition to TAO orbital fibroblasts. This shift is imposed by CD34? orbital fibroblasts but reverts when CD34+ fibroblasts are isolated. The up-regulation of IL-6 by TSH results from coordinately enhanced IL-6 gene promoter activity and increased IL-6 mRNA stability. TSH-dependent IL-6 expression requires activity at both CREB (?213 to ?208 nt) and NF-?B (–78 to ?62 nt) binding sites. These results provide novel insights into the molecular action of TSH and signaling downstream for TSHR in non-thyroid cells. Fibrocytes neither express adenylate cyclase nor generate cAMP and thus these findings are free from any influence of cAMP-related signaling. They identify potential therapeutic targets for TAO.

Raychaudhuri, Nupur; Fernando, Roshini; Smith, Terry J.

2013-01-01

156

Conundrums in the legal protection of migrant workers' health rights and relative resolutions: implications from the case of Tseng Hei-tao.  

PubMed

The deteriorating situation of migrant workers' health rights protection was once again highlighted in the case of Tseng Hei-tao. This case explicitly and implicitly showed that four conundrums--the Employment Restriction Conundrum, the Occupational Safety and Health (OSH) Legal Conundrum, the Morality Conundrum and the Identity Conundrum--are barriers to migrant workers' right protection. The health rights of migrant workers could be safeguarded by abolishing the outdated household registration system designed in the planned economy era, improving the rule of law, and strengthening administrative supervisions. This would fundamentally remove these barriers and thus contribute to migrant workers' health rights protection. PMID:23073738

Liu, Kai

2013-08-01

157

Analysis of meteorological data and water chemistry of Latir Lakes, Taos County, New Mexico, 1985-88  

USGS Publications Warehouse

Data were analyzed to determine the chemistry of atmospheric deposition and water of the Latir Lakes in Taos County New Mexico, from 1985 to 1988. The Latir Lakes consist of a series of nine paternoster lakes that range in altitude from 11,061 to 11,893 feet above sea level. The pH of wet precipitation generally ranged from 4.6 to 5.5 and the specific conductance of wet precipitation ranged from 1 to 18 microsiemens per centimeter at 25 degrees Celsius from December 1985 through September 1988. Snowpack chemistry data indicate a change in the specific conductance, pH, and alkalinity of the snowpack from month to month. The dominant cation in the snowpack is calcium, and the dominant anions are nitrate and sulfate. The samples having the smallest values of specific conductance generally did not contain measurable alkalinity. When the snowpack starts to melt in the spring, specific conductance of the entire snowpack decreases, consistent with the hypothesis that the initial fluid draining from the snowpack transports a large amount of dissolved material out of the snowpack. Water chemistries in the Latir Lakes are similar although specific conductance increases downstream from lake 9 to lake 1. Calcium is the dominant cation and the ions that produce alkalinity are the dominant anions. Concentrations of sodium, magnesium, chloride, and sulfate do not vary substantially from year to year or during the year in a particular lake. Alkalinity and calcium concentration, however, do vary from year to year and during the year. The pH of outflow from the Latir Lakes varies from lake to lake and from year to year. In 1986, the range in pH in the lakes was less than 1 unit in mid-June, but was greater than 2.5 units by late October. The pH generally was larger than 7.0 in all of the lakes and was as large as 9.9 in several of the lakes during the period of study. The pH of outflow water generally increases from early spring to late summer in the Latir Lakes, and snowmelt does not seem to cause the pH to decrease in the lakes. Depth profiles of selected lakes indicate that the dissolved-oxygen concentration approaches zero below the thermocline. This suggests biological oxidation of organic matter in the lower zones in these lakes. Because many organisms cannot live in water containing small dissolved-oxygen concentrations, large volumes of water in lakes 9 and 3 probably are not suitable for habitation during the summer months.

Anderholm, S. K.; Roybal, R. G.; Risser, D. W.; Somers, Georgene

1994-01-01

158

Geologic map of the Ute Mountain 7.5' quadrangle, Taos County, New Mexico, and Conejos and Costilla Counties, Colorado  

USGS Publications Warehouse

The Ute Mountain 7.5' quadrangle is located in the south-central part of the San Luis Basin of northern New Mexico, in the Rio Grande del Norte National Monument, and contains deposits that record volcanic, tectonic, and associated alluvial and colluvial processes over the past four million years. Ute Mountain has the distinction of being one of the largest intermediate composition eruptive centers of the Taos Plateau, a largely volcanic tableland occupying the southern portion of the San Luis Basin. Ute Mountain rises to an elevation in excess of 3,000 m, nearly 700 m above the basaltic plateau at its base, and is characterized by three distinct phases of Pliocene eruptive activity recorded in the stratigraphy exposed on the flanks of the mountain and in the Rio Grande gorge. Unconformably overlain by largely flat-lying lava flows of Servilleta Basalt, the area surrounding Ute Mountain records a westward thickening of basin-fill volcanic deposits interstratified in the subsurface with Pliocene basin-fill sedimentary deposits derived from older Tertiary and Precambrian sources to the east. Superimposed on this volcanic stratigraphy are alluvial and colluvial deposits derived from the flanks of Ute Mountain and more distally-derived alluvium from the uplifted Sangre de Cristo Mountains to the east, that record a complex temporal and stratigraphic succession of Quaternary basin deposition and erosion. Pliocene and younger basin deposition was accommodated along predominantly north-trending fault-bounded grabens. These poorly exposed fault scarps cutting lava flows of Ute Mountain volcano. The Servilleta Basalt and younger surficial deposits record largely down-to-east basinward displacement. Faults are identified with varying confidence levels in the map area. Recognizing and mapping faults developed near the surface in young, brittle volcanic rocks is difficult because: (1) they tend to form fractured zones tens of meters wide rather than discrete fault planes, (2) the relative youth of the deposits has resulted in only modest displacements on most faults, and (3) some of the faults may have significant strike-slip components that do not result in large vertical offsets that are readily apparent in offset of sub-horizontal contacts. Those faults characterized as “certain” either have distinct offset of map units or had slip planes that were directly observed in the field. Lineaments defined from magnetic anomalies form an additional constraint on potential fault locations and are indicated as such on the map sheet.

Thompson, Ren A; Turner, Kenzie J.; Shroba, Ralph R.; Cosca, Michael A.; Ruleman, Chester A.; Lee, John P.; Brandt, Theodore R.

2014-01-01

159

Spectroscopic Investigations on Ln(Zr1/3Ti2/3)TaO6 (Ln = Ce, Pr, Nd and Eu) Ceramics  

NASA Astrophysics Data System (ADS)

In the present work, the authors have performed vibrational spectroscopic study of Ln(Zr1/3Ti2/3)TaO6 (Ln = Ce, Pr, Nd and Eu) ceramics by analyzing their Raman spectra. An attempt is made to correlate the structure and microwave dielectric properties of the samples with their vibrational spectroscopic characteristics. The Raman spectra are analyzed mainly on the basis of TaO6 octahedra. Zr substitution in LnTiTaO6 has not changed the prominent phase, however, the movement towards euxenite structure with increase in atomic number of the lanthanide has become faster. The broadening and splitting of lines observed in Nd and Eu based compounds indicate the distortion of octahedra. The negative value of ?f of Eu based compounds indicates the presence of euxenite phase in addition to the prominent aeschynite phase. This is confirmed by the maximum distortion of the octahedra as indicated by the lower wavenumber, broadening and splitting of the characteristic Raman lines. The Raman shift of ?2(Eg) mode showed a variation similar to ?r and ?f with the ionic radii of the lanthanide ions.

John, Annamma; Solomon, Sam; Kumar, H. Padma; Suresh, M. K.; Deepa, A. S.; Thomas, J. K.

2008-11-01

160

The Tao of SOA  

NASA Astrophysics Data System (ADS)

This paper describes a comprehensive framework aiming to facilitate the effective adoption and operationalization of SOA in large enterprise computing environments, which consists of the Strategy, Automation, Methodology, Patterns, Lifecycle, and Engineering (SAMPLE) aspects. The major pain points in SOA are analyzed, such as the increasing dynamics, growing integration, proliferation of techniques, more heterogeneous platforms, disparate visual notations, intricate processes, disjointed operating models, and fragmented activities of WS-* specifications. The overarching SAMPLE model is designed to provide a sophisticated integration of appropriate capabilities and knowledge to filter the inessential from the essential. In the Strategy aspect, a metamodel, technology architecture planning, and strategy roadmapping are presented. The Automation aspect deals with tools, service lifecycle, and COTS mapping. The Methodology aspect covers a hybrid method, SOA principles, and a methodical process. The prominent elements of the Patterns aspect include data caching patterns, a reference model, and open source reference implementation. The Lifecycle aspect contains a methodical means to mature IT systems: review, refactoring, reengineering, and rearchitecting (R4). Finally, the Engineering aspect evolves the traditional software engineering and systems engineering practices to the service engineering discipline. Moreover, a 10-point list of SOA guidance is introduced from a practitioner’s standpoint, which gives best-practice guidelines to adopt and execute SOA practically in big organizations.

Shan, Tony C.

161

Digital data and derivative products from a high-resolution aeromagnetic survey of the central San Luis basin, covering parts of Alamosa, Conejos, Costilla, and Rio Grande counties, Colorado, and Taos county, New Mexico  

USGS Publications Warehouse

This report describes data collected from a high-resolution aeromagnetic survey flown over the central San Luis basin during October, 2004, by PRJ, Inc., on contract to the U.S. Geological Survey (USGS). The survey extends from just north of Alamosa, Colorado, southward to just northwest of Taos, New Mexico. It covers large parts of the San Luis Valley in Alamosa, Conejos, Costilla, and Rio Grande Counties, southern Colorado, and the Taos Plateau in Taos County, northern New Mexico. The survey was designed to complement two surveys previously acquired along the eastern borders of the San Luis Basin over the vicinities of Taos, New Mexico (Bankey and others, 2004a) and Blanca, Colorado (Bankey and others, 2004b). Our overall objective in conducting these surveys is to improve knowledge of the subsurface geologic framework in order to understand ground-water systems in populated alluvial basins along the Rio Grande. These USGS efforts are conducted in collaboration with other federal, state, and local governmental entities where possible.

Bankey, Viki; Grauch, V. J. S.; Webbers, Ank; PRJ, Inc.

2005-01-01

162

Rotational and hyperfine analysis of the E2?1/2-X2?3/2 electronic transition of TaO  

NASA Astrophysics Data System (ADS)

We have recorded the E2?1/2-X2?3/2 (0, 0) and (1, 0) bands of TaO at sub-Doppler resolution by intermodulated fluorescence spectroscopy. The data were fitted using a Hamiltonian expressed in a Hund’s case (c) basis set, leading to accurate values for the rotational, lambda-doubling and hyperfine constants of the upper state, which could be definitively assigned as 2?1/2 for the first time. The E2?1/2 state has an energy of T0 = 15876.5764(2) cm-1 and a vibrational interval of ?G1/2 = 925.3164(3) cm-1.

Christopher, Casey R.; Lee, Stephanie Y.; Gwandu, Francis B.; Matsumoto, Andrew J.; Knurr, Benjamin J.; Mahle, Thomas K.; Morrow, Zachary W.; Varberg, Thomas D.

2014-07-01

163

Spred1 and TESK1--Two New Interaction Partners of the Kinase MARKK/TAO1 That Link the Microtubule and Actin Cytoskeleton  

PubMed Central

The signaling from MARKK/TAO1 to the MAP/microtubule affinity-regulating kinase MARK/Par1 to phosphorylated microtubule associated proteins (MAPs) renders microtubules dynamic and plays a role in neurite outgrowth or polarity development. Because hyperphosphorylation of Tau at MARK target sites is a hallmark of Alzheimer neurodegeneration, we searched for upstream regulators by the yeast two-hybrid approach and identified two new interaction partners of MARKK, the regulatory Sprouty-related protein with EVH-1 domain1 (Spred1) and the testis-specific protein kinase (TESK1). Spred1-MARKK binding has no effect on the activity of MARKK; therefore, it does not change microtubule (MT) stability. Spred1-TESK1 binding causes inhibition of TESK1. Because TESK1 can phosphorylate cofilin and thus stabilizes F-actin stress fibers, the inhibition of TESK1 by Spred1 makes F-actin fibers dynamic. A third element in this interaction triangle is that TESK1 binds to and inhibits MARKK. Thus, in Chinese hamster ovary (CHO) cells the elevation of MARKK results in MT disruption (via activation of MARK/Par1 and phosphorylation of MAPs), but this can be blocked by TESK1. Similarly, enhanced TESK1 activity results in increased stress fibers (via phospho-cofilin), but this can be blocked by elevating Spred1. Thus, the three-way interaction between Spred1, MARKK, and TESK1 represents a pathway that links regulation of both the microtubule- and F-actin cytoskeleton.

Johne, Cindy; Matenia, Dorthe; Li, Xiao-yu; Timm, Thomas; Balusamy, Kiruthiga

2008-01-01

164

Proteomic Identification of Nrf2-Mediated Phase II Enzymes Critical for Protection of Tao Hong Si Wu Decoction against Oxygen Glucose Deprivation Injury in PC12 Cells  

PubMed Central

Chinese herbal medicine formula Tao Hong Si Wu decoction (THSWD) is traditionally used in China for cerebrovascular diseases. However, the molecular mechanisms of THSWD associated with the cerebral ischemia reperfusion injury are largely unknown. The current study applied the two-dimensional gel electrophoresis-based proteomics to investigate the different protein profiles in PC12 cells with and without the treatment of THSWD. Twenty-six proteins affected by THSWD were identified by MALDI-TOF mass spectrometry. Gene ontology analysis showed that those proteins participated in several important biological processes and exhibited diverse molecular functions. In particular, six of them were found to be phase II antioxidant enzymes, which were regulated by NF-E2-related factor-2 (Nrf2). Quantitative PCR further confirmed a dose-dependent induction of the six phase II enzymes by THSWD at the transcription level. Moreover, the individual ingredients of THSWD were discovered to synergistically contribute to the induction of phase II enzymes. Importantly, THSWD's protection against oxygen-glucose deprivation-reperfusion (OGD-Rep) induced cell death was significantly attenuated by antioxidant response element (ARE) decoy oligonucleotides, suggesting the protection of THSWD may be likely regulated at least in part by Nrf2-mediated phase II enzymes. Thus, our data will help to elucidate the molecular mechanisms underlying the neuroprotective effect of THSWD.

Qi, Hong-yi; Li, Li; Yu, Jie; Chen, Lu; Huang, Yong-liang; Ning, Ling; Jiang, Zhuyun; Yang, Na; Xu, Xiao-yu

2014-01-01

165

Massively Parallel Assimilation of TOGA/TAO and Topex/Poseidon Measurements into a Quasi Isopycnal Ocean General Circulation Model Using an Ensemble Kalman Filter  

NASA Technical Reports Server (NTRS)

A massively parallel ensemble Kalman filter (EnKF)is used to assimilate temperature data from the TOGA/TAO array and altimetry from TOPEX/POSEIDON into a Pacific basin version of the NASA Seasonal to Interannual Prediction Project (NSIPP)ls quasi-isopycnal ocean general circulation model. The EnKF is an approximate Kalman filter in which the error-covariance propagation step is modeled by the integration of multiple instances of a numerical model. An estimate of the true error covariances is then inferred from the distribution of the ensemble of model state vectors. This inplementation of the filter takes advantage of the inherent parallelism in the EnKF algorithm by running all the model instances concurrently. The Kalman filter update step also occurs in parallel by having each processor process the observations that occur in the region of physical space for which it is responsible. The massively parallel data assimilation system is validated by withholding some of the data and then quantifying the extent to which the withheld information can be inferred from the assimilation of the remaining data. The distributions of the forecast and analysis error covariances predicted by the ENKF are also examined.

Keppenne, Christian L.; Rienecker, Michele; Borovikov, Anna Y.; Suarez, Max

1999-01-01

166

Validation of the NASA GEWEX-SRB Radiation Data over the Tropical Oceans: Comparisons with PIRATA, RAMA, TAO and WHOI Buoy Observations  

NASA Astrophysics Data System (ADS)

The NASA/GEWEX SRB (Global Energy and Water Exchanges, Surface Radiation Budget) project produces and archives shortwave and longwave radiation budget flux estimates at the top of the atmosphere and at the Earth's surface. The latest version in the archive, Release 3.0, is available as 3-hourly, 3-hourly-monthly, daily and monthly means continuously over the period from July 1983 to December 2007 on a quasi-equal-area grid system of 44016 grid boxes. SRB Release 4 with further improvements in data quality and higher spatial resolution is being developed. The SRB shortwave/longwave fluxes at the Earth's surface from the algorithm GSW(V3.0)/GLW(V3.1) have been extensively validated against high-quality ground-based observations, in particular observed data from the Baseline Surface Radiation Network (BSRN). Comparisons with nearly 6000 site-months of both shortwave and longwave data from 52 BSRN sites show generally good agreement. In addition, the GEWEX SRB data have also been found to compare favorably with the World Radiation Data Centre (WRDC) data and the Global Energy Balance Archive (GEBA) data. In spite of the fact that the BSRN sites are scattered on all seven continents, the validation of the SRB data over the vast oceans had not been done until recently. In this paper, we present comparisons of the GEWEX-SRB data shortwave/longwave data with observations made on arrays moored in tropical oceans. Specifically, we have data from 21 buoys, or moorings, from Prediction and Research Moored Array in the Atlantic (PIRATA), 14 buoys from the Research Moored Array for African-Asian-Australian Monsoon Analysis and Prediction (RAMA) in the Indian Ocean, 20 buoys from the Tropical Atmosphere Ocean (TAO) array in the Pacific, and 3 buoys from the Woods Hole Oceanographic Institute (WHOI) (2 in the Pacific and 1 in the Atlantic). The data from these buoys span 12 years from 2000 to 2011, though not necessarily continuously. It is found that except for occasional outliers, the majority of the comparable pairs of data points agree well. For instance, the bias/RMS from 1644 monthly mean data points is 11.1/19.0 W m-2. Further examination of the outliers is necessary to determine whether they can be attributed to wind-driven tilt and/or aerosol accumulation on the instruments. In order to see how the ocean-based validation compares with land-based validation, we made SRB-BSRN monthly mean shortwave/longwave radiation comparisons in the tropical region only, where all the buoys are moored. The results show that in the case of shortwave radiation, the bias error from the ocean-based validation is somewhat larger than its land-based counterpart, but their RMS errors are not significantly different. In the case of longwave radiation, the ocean-based and land-based validations show nearly identical comparison statistics.

Zhang, T.; Stackhouse, P. W.; Gupta, S. K.; Cox, S. J.; Mikovitz, J. C.

2013-12-01

167

Validation of the NASA GEWEX-SRB Radiation Data over the Tropical Oceans: Comparisons with PIRATA, RAMA, TAO and WHOI Buoy Observations  

NASA Astrophysics Data System (ADS)

The NASA GEWEX-SRB (Global Energy and Water Exchanges - Surface Radiation Budget) project produces and archives shortwave and longwave radiation budget data at the top of the atmosphere and the Earth's Surface. The latest version in the archive, Release 3.0, is available as 3-hourly, 3-hourly-monthly, daily and monthly means continuously over the period from July 1983 to December 2007 on a quasi-equal-area grid system of 44016 grid boxes. Releases 4 and 5 with further improved quality and higher spatial resolution are being planned. The SRB shortwave/longwave fluxes at the Earth's surface from the algorithm GSW(V3.0)/GLW(V3.1) have been extensively validated against high-quality ground-based observations, in particular observed data from the Baseline Surface Radiation Network (BSRN). Comparisons with nearly 6000 site-months of both shortwave and longwave data from 52 BSRN sites show generally good agreement. In addition, the GEWEX SRB data have also been found to compare favorably with the World Radiation Data Centre (WRDC) data and the Global Energy Balance Archive (GEBA) data. In spite of the fact that the BSRN sites are scattered on all seven continents, the validation of the SRB data over the vast oceans had not been done until recently. In this paper, we present comparisons of the GEWEX-SRB data shortwave/longwave data with observations made on arrays moored in tropical oceans. Specifically, we have data from 21 buoys, or moorings, from Prediction and Research Moored Array in the Atlantic (PIRATA), 14 buoys from the Research Moored Array for African-Asian-Australian Monsoon Analysis and Prediction (RAMA) in the Indian Ocean, 20 buoys from the Tropical Atmosphere Ocean (TAO) array in the Pacific, and 3 buoys from the Woods Hole Oceanographic Institute (WHOI) (2 in the Pacific and 1 in the Atlantic). The data from these buoys span 12 years from 2000 to 2011, though not necessarily continuously. It is found that except for occasional outliers, the majority of the comparable pairs of data points agree well. Further examination of the outliers is necessary to determine whether they can be attributed to wind-driven tilt and/or aerosol accumulation on the instruments. In order to see how the ocean-based validation compares with land-based validation, we made SRB-BSRN monthly mean shortwave/longwave radiation comparisons in the tropical region only, the region in which all the buoys are moored. The results show that in the case of shortwave radiation, the bias error from the ocean-based validation is somewhat larger than its land-based counterpart, but their RMS errors are not significantly different. In the case of longwave radiation, the ocean-based and land-based validations show nearly identical comparison statistics.

Zhang, T.; Stackhouse, P. W., Jr.; Gupta, S. K.; Cox, S. J.; Mikovitz, J. C.; NASA Gewex Srb Project Team

2013-05-01

168

2012 European Thyroid Association Guidelines for Metastatic Medullary Thyroid Cancer  

PubMed Central

Distant metastases are the main cause of death in patients with medullary thyroid cancer (MTC). These 21 recommendations focus on MTC patients with distant metastases and a detailed follow-up protocol of patients with biochemical or imaging evidence of disease, selection criteria for treatment, and treatment modalities, including local and systemic treatments based on the results of recent trials. Asymptomatic patients with low tumor burden and stable disease may benefit from local treatment modalities and can be followed up at regular intervals of time. Imaging is usually performed every 6–12 months, or at longer intervals of time depending on the doubling times of serum calcitonin and carcinoembryonic antigen levels. Patients with symptoms, large tumor burden and progression on imaging should receive systemic treatment. Indeed, major progress has recently been achieved with novel targeted therapies using kinase inhibitors directed against RET and VEGFR, but further research is needed to improve the outcome of these patients.

Schlumberger, M.; Bastholt, L.; Dralle, H.; Jarzab, B.; Pacini, F.; Smit, J.W.A.

2012-01-01

169

The Tao of Teaching: Romance and Process.  

ERIC Educational Resources Information Center

Because college teaching aims to elevate, not entertain, it must be nourished and appreciated as a pedagogical alchemy mixing facts and feelings, ideas and skills, history and mystery. The current debate on educational reform should focus more on quality of learning experience, and on how to create and sustain it. (MSE)

Schindler, Stefan

1991-01-01

170

Drug-induced graves disease from CTLA-4 receptor suppression.  

PubMed

Monoclonal antibody, ipilimumab, useful for treatment of metastatic melanoma, blocks CTLA-4 mediated T-cell suppression and can also cause a Graves ophthalmopathy like syndrome. Epidemiologic study has linked variant polymorphisms of CTLA-4 receptor gene to the presence of thyroid eye disease. The combination of these observations suggests CTLA-4 mediated T-cell functions are important to the pathogenesis of thyroid-associated eye disease. PMID:21242854

Borodic, Gary; Hinkle, David M; Cia, Yihong

2011-01-01

171

Questa Baseline and Pre-Mining Ground-Water Quality Investigation. 17. Geomorphology of the Red River Valley, Taos County, New Mexico, and Influence on Ground-Water Flow in the Shallow Alluvial Aquifer  

USGS Publications Warehouse

In April 2001, the U.S. Geological Survey (USGS) and the New Mexico Environment Department (NMED) began a cooperative study to infer the pre-mining ground-water chemistry at the Molycorp molybdenum mine site in the Red River Valley of north-central New Mexico. This report is one in a series of reports that can be used to determine pre-mining ground-water conditions at the mine site. Molycorp?s Questa molybdenum mine in the Red River Valley, northern New Mexico, is located near the margin of the Questa caldera in a highly mineralized region. The bedrock of the Taos Range surrounding the Red River is composed of Proterozoic rocks of various types, which are intruded and overlain by Oligocene volcanic rocks associated with the Questa caldera. Locally, these rocks were altered by hydrothermal activity. The alteration zones that contain sulfide minerals are particularly important because they constitute the commercial ore bodies of the region and, where exposed to weathering, form sites of rapid erosion referred to as alteration scars. Over the past thousand years, if not over the entire Holocene, erosion rates were spatially variable. Forested hillslopes eroded at about 0.04 millimeter per year, whereas alteration scars eroded at about 2.7 millimeters per year. The erosion rate of the alteration scars is unusually rapid for naturally occurring sites that have not been disturbed by humans. Watersheds containing large alteration scars delivered more sediment to the Red River Valley than the Red River could remove. Consequently, large debris fans, as much as 80 meters thick, developed within the valley. The geomorphology of the Red River Valley has had several large influences on the hydrology of the shallow alluvial aquifer, and those influences were in effect before the onset of mining within the watershed. Several reaches where alluvial ground water emerges to become Red River streamflow were observed by a tracer dilution study conducted in 2001. The aquifer narrows where erosion-resistant bedrock, which tends to form vertical cliffs, restricts the width of the valley bottom. Although the presence of a shallow bedrock sill, overlain by shallow alluvium, is a plausible cause of ground-water emergence, this cause was not demonstrated in the study area. The water-table gradient can locally decrease in the downstream direction because of changes in the hydraulic properties of the alluvium, and this may be a contributing cause of ground-water emergence. However, at one site (near Cabin Springs), ground-water emergence could not be explained by spatial changes in geometric or hydraulic properties of the aquifer. Furthermore, the available evidence demonstrates that ground water flowing through bedrock fractures or colluvium entered the north side of the alluvial aquifer, and is the cause of ground-water emergence. At that location the alluvial aquifer was already flowing full, causing the excess water to emerge into the stream. An indirect consequence of altered rock in the tributary watersheds is the rapid erosion rate of alteration scars combined with the hydraulic properties of sediments shed from those scars. Where alteration scars are large the debris fans at the mouths of the tributary watersheds substantially encroach into the Red River Valley. At such locations debris-fan materials dominate the width and thickness of the alluvium in the valley and reduce the rate of flow of ground water within the Red River alluvial aquifer. Most sites of groundwater emergence are located immediately upstream from or along the margins of debris fans. A substantial fraction of the ground water approaching a debris fan can emerge to become streamflow. This last observation has three implications. First, very little water can flow the entire length of the study area entirely within the alluvial aquifer because the ground water repeatedly contacts debris-fan sediments over that length. Second, it follows that emerging water containing

Vincent, Kirk R.

2008-01-01

172

77 FR 59703 - Environmental Impact Statement; Taos Regional Airport, Taos, NM  

Federal Register 2010, 2011, 2012, 2013

...shortening of the existing Runway 4/22 by 420 feet to the northeast with an associated shift of the RSA Runway Object Free Area (ROFA), and Runway Protection Zone (RPZ), establishment of new flight procedures for both runways, construction of a new...

2012-09-28

173

Management plan and delivery of care in Graves' ophthalmopathy patients.  

PubMed

Most patients with Graves' orbitopathy have mild disease that requires no or minimal intervention. For the minority of patients with moderate or severe disease, multiple medical and surgical treatments may be required at different stages. It is crucial that such patients are monitored closely and treatments applied with care in the right sequence. Medical treatments should be used as early as possible and only during the active phase of the disease. Rehabilitative surgery is indicated in the inactive phase of the disease and should follow the sequence: surgical decompression followed by eye muscle surgery, followed by lid surgery. Delivery of care in a coordinated fashion that makes use of best available expertise is important and best implemented through a Combined Thyroid Eye clinic. PMID:22632367

Yang, Morgan; Perros, Petros

2012-06-01

174

Polymorphisms of the glucocorticoid receptor gene in Graves ophthalmopathy  

Microsoft Academic Search

Background\\/aims:Glucocorticoids have an important role in the regulation of the immune system, and alterations in glucocorticoid signaling may have an impact on the pathophysiology of autoimmune and inflammatory disorders. Because polymorphisms of the glucocorticoid receptor (GR) gene, including the N363S, ER22\\/23EK, A3669G and BclI variants were found to influence glucocorticoid signalling, we examined whether these polymorphisms could be associated with

B Boyle; K Korányi; A Patocs; I Liko; A Szappanos; R Bertalan; K Racz; C Balazs

2008-01-01

175

Lipid research picks up speed on the slopes of Taos.  

PubMed

The 2002 Keystone Symposium on "Regulation of Cellular Responses by Lipid Mediators" provided a lively and active forum to discuss research in lipid signaling. This meeting review can provide only a glimpse into the diversity of research presented. Here we have chosen to highlight a group of exciting presentations describing novel features of the temporal and spatial regulation of phosphoinositides and their downstream targets. PMID:11970891

Field, Seth J; Lamia, Katja A; Rameh, Lucia E; Cantley, Lewis C

2002-04-01

176

Tao of Gateway: Providing Internet Access to Licensed Databases.  

ERIC Educational Resources Information Center

Illustrates an approach for providing networked access to licensed databases over the Internet by positioning the library between patron and vendor. Describes how the gateway systems and database connection servers work and discusses how treatment of security has evolved with the introduction of the World Wide Web. Outlines plans to reimplement…

McClellan, Gregory A.; Garrison, William V.

1997-01-01

177

Learning to teach at the elbows: The tao of teaching  

Microsoft Academic Search

The metaphor learning to teach at the elbows is put forward in this article to highlight claims about learning to teach that focus on the development of “teaching manner.” My particular interest is in characterizing and understanding aspects of teaching that seem to be acquired, shared, mediated, and changed through teachers' work together—a shaping which I believe occurs initially through

Allan Mackinnon

1996-01-01

178

Amiodarone-Induced Destructive Thyroiditis Associated with Coronary Artery Vasospasm and Recurrent Ventricular Fibrillation  

PubMed Central

A 55-year-old male on long-term amiodarone therapy presented with ischaemic chest pain and recurrent unwitnessed syncope. Interrogation of his internal cardiac defibrillator, which had been inserted 4 years earlier, revealed two episodes of ventricular fibrillation, the timing of which corresponded to his syncopal events. Severe spontaneous coronary artery vasospasm was observed on coronary angiogram. Thyroid function testing revealed severe hyperthyroidism with a diagnosis of type 2 amiodarone-induced thyrotoxicosis (AIT) subsequently made. Treatment with prednisolone therapy was commenced and thyroid function rapidly normalized. Prednisolone was weaned without recurrence of hyperthyroidism and on last review, 6 months after initial presentation, he remains free from further chest pain and arrhythmias. Our patient's presentation is a very rare case of AIT-associated coronary artery spasm and documented ischaemic ventricular fibrillation with fortunate survival.

Brooks, Matthew J.; Pattison, David A.; Teo, Eliza P.; Price, Sarah; Gurvitch, Ronen

2013-01-01

179

77 FR 36994 - Questa Ranger District, Carson National Forest; Taos County, NM; Taos Ski Valley's 2010 Master...  

Federal Register 2010, 2011, 2012, 2013

...intent was published in the Federal Register on September 29, 2011 (76 FR 60451) modifying the proposed action to relocate the snow tubing area and add the relocation of an existing footbridge across the Rio Hondo. The Environmental Protection Agency...

2012-06-20

180

Autoimmune thyroid diseases: genetic susceptibility of thyroid-specific genes and thyroid autoantigens contributions.  

PubMed

Autoimmune thyroid diseases are common polygenic multifactorial disorders with the environment contributing importantly to the emergence of the disease phenotype. Some of the disease manifestations, such as severe thyroid-associated ophthalmopathy, pretibial myxedema and thyroid antigen/antibody immune complex nephritis are unusual to rare. The spectrum of autoimmune thyroid diseases includes: Graves' disease (GD), Hashimoto's thyroiditis (HT), atrophic autoimmune thyroiditis, postpartum thyroiditis, painless thyroiditis unrelated to pregnancy and thyroid-associated ophthalmopathy. This spectrum present contrasts in terms of thyroid function, disease duration and spread to other anatomic location. The genetic basis of autoimmune thyroid disease (AITD) is complex and likely to be due to genes of both large and small effects. In GD the autoimmune process results in the production of thyroid-stimulating antibodies and lead to hyperthyroidism, whereas in HT the end result is destruction of thyroid cells and hypothyroidism. Recent studies in the field of autoimmune thyroid diseases have largely focused on (i) the genes involved in immune response and/or thyroid physiology with could influence susceptibility to disease, (ii) the delineation of B-cell autoepitopes recognized by the main autoantigens, thyroglobulin, thyroperoxidase and TSH receptor, to improve our understanding of how these molecules are seen by the immune system and (iii) the regulatory network controlling the synthesis of thyroid hormones and its dysfunction in AITD. The aim of the present review is to summarize the current knowledge regarding the relation existing between some susceptibility genes, autoantigens and dysfunction of thyroid function during AITD. PMID:19284442

Hadj-Kacem, H; Rebuffat, S; Mnif-Féki, M; Belguith-Maalej, S; Ayadi, H; Péraldi-Roux, S

2009-04-01

181

Expression of Thyrotropin Receptor, Thyroglobulin, Sodium-Iodide Symporter, and Thyroperoxidase by Fibrocytes Depends on AIRE.  

PubMed

Context: CD34(+) fibrocytes, bone marrow-derived progenitor cells, infiltrate orbital connective tissue in thyroid-associated ophthalmopathy, a manifestation of Graves' disease. In the orbit, they become CD34(+) fibroblasts and coexist with native CD34(-) fibroblasts. Fibrocytes have been shown to express TSH receptor and thyroglobulin. Objective: The objective of the study was to determine whether a broader repertoire of thyroid protein expression can be detected in fibrocytes and whether a common factor is responsible. Design/Setting/Participants: Fibrocytes and fibroblasts were collected and analyzed from healthy individuals and those with Graves' disease in an academic clinical practice. Main Outcome Measures: Real-time PCR, Western blot analysis, gene promoter analysis, cell transfections, and flow cytometric cell sorting were performed. Results: We detect two additional thyroid proteins expressed by fibrocytes, namely sodium-iodide symporter and thyroperoxidase. The autoimmune regulator (AIRE) protein appears necessary for this expression. AIRE expression in fibrocytes results from an active AIRE gene promoter and stable AIRE mRNA. Knocking down AIRE with a targeting small interfering RNA reduces the expression of these thyroid proteins in fibrocytes as well as the transcription factors paired box-8 and thyroid transcription factor-1. When compared with an unaffected first-degree relative, levels of these proteins are substantially reduced in fibrocytes from an individual with an inactivating AIRE mutation. Levels of AIRE and the thyroid proteins are lower in orbital fibroblasts from patients with thyroid-associated ophthalmopathy than in fibrocytes. However, when mixed fibroblast populations are sorted into pure CD34(+) and CD34(-) subsets, the levels of these proteins are dramatically increased selectively in CD34(+) fibroblasts. Conclusions: Fibrocytes express four proteins, the aggregate expression of which was previously thought to be restricted to thyroid epithelium. These proteins represent the necessary molecular biosynthetic machinery necessary for thyroid hormone production. Our findings implicate AIRE in the promiscuous expression of thyroid proteins in fibrocytes. PMID:24708100

Fernando, Roshini; Lu, Ying; Atkins, Stephen J; Mester, Tunde; Branham, Kari; Smith, Terry J

2014-07-01

182

TAO (Tactical Action Officer) ASW (Anti-Submarine Warfare) Expert System Prototype.  

National Technical Information Service (NTIS)

The expertise required by Tactical Action Officers in a modern Anti-Submarine warfare environment of complex weaponry, minimal reaction time and ardous conditions at sea necessitate training and experience that is both exhaustive and progressive. For thes...

G. A. Gostlow

1986-01-01

183

Tao stoics : late twentieth century lessons in wisdom or subjects for discussion  

Microsoft Academic Search

The book discusses many pieces of wisdom and human dignity,ethics and happiness as there are in the books of all ages, but now relative to the lethal problems of today. The set-up of the master-disciple relation, which is used in the television Kung Fu series, is applied and of the other Chinese wise, just as in literature nowadays, i.e. by

L. León

1990-01-01

184

Geologic map of the Ojo Caliente Quadrangle, Rio Arriba and Taos Counties, New Mexico  

SciTech Connect

The Ojo Caliente area forms part of the western limb of the Espanola basin within the Rio Grande rift of northern New Mexico (Manley, 1979; May, 1979). The geology consists of Miocene basin-fill sedimentary rocks that rest unconformably on, or are faulted against, Proterozoic crystalline metamorphic rocks. The Miocene rocks dip gently to the southeast, except where the attitudes are controlled by faulting or by the underlying basement topography. The Precambrian and Miocene rocks are unconformably overlain by Quaternary pediment and river gravels, loess, travertine, landslide debris, and alluvium. The Precambrian rocks are faulted into horsts in several areas by north - northeast - trending normal faults.

Stix, J. (comp.)

1986-11-01

185

Relapse Prevention for Alcohol and Drug Problems: That Was Zen, This Is Tao  

Microsoft Academic Search

Relapse prevention, based on the cognitive-behavioral model of relapse, has become an adjunct to the treatment of numerous psychological problems, including (but not limited to) substance abuse, depression, sexual offending, and schizophrenia. This article provides an overview of the efficacy and effectiveness of relapse prevention in the treatment of addictive disorders, an update on recent empirical support for the elements

Katie Witkiewitz; G. Alan Marlatt

2004-01-01

186

Thermodynamic evaluation of the Ta–O system from pure tantalum to tantalum pentoxide  

Microsoft Academic Search

The partial thermodynamic functions of the tantalum–oxygen system (up to O\\/Ta=2.5) were evaluated from 873 to 3120 K. The pressure–composition–temperature (p–C–T) relationship in the single-phase region of solid Ta was investigated. Relationships for other phases where no data are available in the literature were proposed based on thermodynamic analysis. The results are presented as oxygen isobars superimposed on a phase

Hyun Seon Hong; Kyung Sub Lee

2003-01-01

187

2012 European Thyroid Association Guidelines for the Management of Familial and Persistent Sporadic Non-Autoimmune Hyperthyroidism Caused by Thyroid-Stimulating Hormone Receptor Germline Mutations  

PubMed Central

All cases of familial thyrotoxicosis with absence of evidence of autoimmunity and all children with persistent isolated neonatal hyperthyroidism should be evaluated for familial non-autoimmune autosomal dominant hyperthyroidism (FNAH) or persistent sporadic non-autoimmune hyperthyroidism (PSNAH). First, all index patients should be analysed for the presence/absence of a thyroid-stimulating hormone (TSH) receptor (TSHR) germline mutation, and if they display a TSHR germline mutation, all other family members including asymptomatic and euthyroid family members should also be analysed. A functional characterization of all new TSHR mutations is necessary. Appropriate ablative therapy is recommended to avoid relapses of hyperthyroidism and its consequences, especially in children. Therefore, in children the diagnosis of FNAH or PSNAH needs to be established as early as possible in the presence of the clinical hallmarks of the disease.

Paschke, R.; Niedziela, M.; Vaidya, B.; Persani, L.; Rapoport, B.; Leclere, J.

2012-01-01

188

Guidelines for TSH-receptor antibody measurements in pregnancy: results of an evidence-based symposium organized by the European Thyroid Association  

Microsoft Academic Search

Hyperthyroidism due to Graves' disease is induced by autoantibodies stimulating the thyroid-stimulating hor- mone (TSH) receptor. In most patients these antibodies can be measured in serum. Graves' disease is common in women of reproductive age, with a prevalence rate of past or present disease of 0.5-1% (1). Classically, three therapeutic approaches are used: (i) Antithyroid drugs given for a long

Peter Laurberg; Birte Nygaard; Daniel Glinoer; Martin Grussendorf; Jacques Orgiazzi

1998-01-01

189

Whole-body 18F-FDG PET\\/CT in primary non-Hodgkin's lymphoma of the thyroid associated with Hashimoto's thyroiditis and bilateral kidney infiltration  

Microsoft Academic Search

An 82-year-old female patient with hypothyroidism and Hashimoto's thyroiditis noted three years ago to have a small asymmetric goiter (left > right). Nevertheless, a rapid growth of the thyroid over 3-6 months caused dysphagia and shortness of breath. Ultrasound and a thyroid gammagram showed an image consistent with multinodular goiter with a hyperfunctioning nodule in the right lobe. Due to

E. Roldán-Valadez; N. Ortega-López; E. Cervera-Ceballos; G. Valdivieso-Cárdenas; I. Vega-González; M. Granados-García

2008-01-01

190

Increased CXCL9 serum levels in hepatitis C-related mixed cryoglobulinemia, with autoimmune thyroiditis, associated with high levels of CXCL10.  

PubMed

Until now, no study has evaluated CXCL9 in hepatitis C virus (HCV) infection-related mixed cryoglobulinemia (MC) patients in presence/absence of autoimmune thyroiditis (AT). Serum CXCL9 and CXCL10 have been measured in 60 patients with MC (MCo), in 35 patients with MC and AT (MC-AT), in sex and age-matched controls: 60 healthy (Control 1); 35 patients with AT without cryoglobulinemia (Control 2). CXCL9 and CXCL10 were higher in MC-AT patients than Control 2 (P<0.0001) and MCo (P=0.01), in MCo than Control 1 (P<0.0001), and in Control 2 than Control 1 (P<0.001). By defining a high CXCL9 level as a value>2 SD above the mean value of the Control 1 (>122?pg/mL), 5% of Control 1, 34% of Control 2, 91% of MCo, and 97% of MC+AT had high CXCL9 (P<0.0001, chi-square). By simple regression analysis CXCL9 and CXCL10 were related to each other in MCo (r=0.426, P=0.001) and in MC-AT (r=0.375, P=0.001). We first demonstrate high serum levels of CXCL9 in cryoglobulinemic patients, especially with AT. Further, a strong association between serum CXCL9 and CXCL10 has been observed in patients with MC in presence/absence of AT. PMID:23902475

Antonelli, Alessandro; Fallahi, Poupak; Ferrari, Silvia Martina; Colaci, Michele; Giuggioli, Dilia; Saraceno, Giovanna; Benvenga, Salvatore; Ferri, Clodoveo

2013-12-01

191

ANIR: Infrared-Optical Simultaneous Imager for miniTAO 1 m Telescope at an Altitude of 5640 m  

SciTech Connect

Early follow-up observations of gamma-ray bursts (GRBs) in wide wavelength range, especially from the optical to the near infrared (NIR) bands, are crucial for search of high-redshift GRBs by detecting their Lyman limit break. For this purpose, we have developed a NIR/optical simultaneous imager called ANIR (Atacama Near InfraRed camera) for the University of Tokyo Atacama 1.0 m telescope. Installed at the summit of Co. Chajnantor (5640 m altitude) in northern Chile, this telescope is the world's highest optical/NIR observatory. ANIR saw the first light in June 2009, and several observing runs have been carried out for performance verification as well as scientific observations. During the run, we have successfully detected an optical/NIR afterglow of GRB091018. Thanks to the excellent seeing (median {approx}0''.8), 5{sigma} limiting magnitudes reach 23.3, 20.6, and 20.8 mag(AB) in the B, J and Ks bands, respectively, with 600 sec exposure.

Motohara, Kentaro; Konishi, Masahiro; Mitani, Natsuko; Sako, Shigeyuki; Uchimoto, Yuka K.; Toshikawa, Koji; Minezaki, Takeo; Tanabe, Toshihiko; Miyata, Takashi; Koshida, Shintaro; Nakamura, Tomohiko; Asano, Kentaro; Yoshii, Yuzuru; Doi, Mamoru; Kohno, Kotaro; Tanaka, Masuo; Kawara, Kimiaki; Handa, Toshihiro [Institute of Astronomy, University of Tokyo, Osawa 2-21-1, Mitaka, Tokyo 181-0015 (Japan); Ohsawa, Ryou; Umeda, Hideyuki [Department of Astronomy, University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033 (Japan)

2010-10-15

192

Movement as a Metaphor: How Persistence, the Tao, and the Wisdom of the Ostrich Helped Build School Dance Programs  

ERIC Educational Resources Information Center

Those who advocate for dance in education inevitably face many roadblocks, including ignorance of how dance can contribute to education, implementation of standardized performance assessments, lack of funding, entrenched issues of politics and power, and fear and discomfort about the body. It is dance teachers' responsibility to enlighten,…

Kaufman, Karen

2011-01-01

193

Geopolitics of Quantum Buddhism: Our Pre-Hydrocarbon Tao Future (No Breakthrough at the Rio+20 Summit)  

ERIC Educational Resources Information Center

From Rio to Rio with Kyoto, Copenhagen and Durban in between, the conclusion remains the same: we fundamentally disagree on realities of this planet and the ways we can address them. A decisive breakthrough would necessitate both wider contexts and a larger participatory base so as to identify problems, formulate policies, and broaden and…

Bajrektarevic, Anis

2013-01-01

194

Localization of the human 64kD autoantigen D1 to myofibrils in a subset of extraocular muscle fibers  

NASA Technical Reports Server (NTRS)

PURPOSE. To evaluate the tissue-specific expression pattern of the 64kD human autoantigen D1, a tropomodulin-related protein that may be involved in thyroid-associated ophthalmopathy. METHODS. Recombinant 64kD human autoantigen D1 was generated in a bacterial expression system and used to immunize rabbits. Specific antibodies were affinity-purified and used for Western blots on normal and hyperthyroid rat and rabbit tissue, and immunofluorescence localization on cryosections of rat tissue. RESULTS. Anti-64kD human autoantigen D1 antibodies recognize specifically a approximately 70kD polypeptide in western blots of extraocular muscle, sternothyroid muscle, and smooth muscle. Immunofluorescence staining demonstrates that the 64kD human autoantigen D1 localizes to myofibrils in slow fibers from rat extraocular and sternothyroid muscle. The level of this protein is not altered in extraocular muscles from hyperthyroid rabbits. CONCLUSIONS. The 64kD human autoantigen D1 is expressed in slow fibers of extraocular and sternothyroid muscles as a component of myofibrils, and is not upregulated in conditions of hyperthyroidism.

Conley, C. A.; Fowler, V. M.

1999-01-01

195

Association of MICA Alleles with Autoimmune Thyroid Disease in Korean Children  

PubMed Central

Background. Major histocompatibility complex class I chain-related gene A (MICA) is a ligand for the activating NKG2D receptor expressed on natural killer (NK) cells. We aimed to assess the association of MICA polymorphism with autoimmune thyroid disease (AITD) in Korean children. Methods. Eighty-one patients with AITD were recruited. We analyzed MICA polymorphisms by PCR-SSP and compared the results with those of 70 healthy controls. Results. In AITD, the allele frequencies of MICA?010 (OR = 2.21; 95% CI, 1.30–3.76, P < 0.003, Pc < 0.042) were higher than those of controls. Patients who did not have thyroid-associated ophthalmopathy showed higher frequencies of MICA?010 (OR = 2.99; 95% CI, 1.47–6.08, P < 0.003, Pc < 0.042) and lower frequencies of MICA?008 (OR = 0.08; 95% CI, 0.01–0.62, P < 0.001, Pc < 0.014) compared to those of controls. HLA-B?46, which shows the strongest association with AITD compared with other HLA alleles, showed the strongest linkage disequilibrium with MICA?010. Analyses of the associations between MICA?010 and HLA-B?46 with AITD suggest an association of the MICA allele with AITD. Conclusions. Our results suggest that innate immunity might contribute to the pathogenesis of AITD.

Cho, Won Kyoung; Jung, Min Ho; Park, So Hyun; Baek, In Cheol; Choi, Hee-Baeg; Kim, Tai-Gyu; Suh, Byung-Kyu

2012-01-01

196

Immunopathogenesis of Thyroid Eye Disease: Emerging Paradigms  

PubMed Central

Graves disease represents a systemic autoimmune process targeting the thyroid, orbit, and pretibial skin. The thyroid dysfunction is treatable, but no consistently effective medical therapy has yet been described for the orbital manifestations of Graves disease, also known as thyroid-associated ophthalmopathy or thyroid eye disease. Several autoantigens are potentially relevant to the pathogenesis of thyroid eye disease. Activating antibodies generated against the thyrotropin receptor can be detected in a majority of patients, and these drive hyperthyroidism. However, stimulating antibodies against the insulin-like growth factor-1 receptor (IGF-1R) may also play a role in the extra-thyroid manifestations of GD. IGF-1R is over-expressed by orbital fibroblasts derived from patients with TED, while IGF-1R+ T and IGF-1R+ B cells are considerably more frequent in GD. Actions of several cytokines and the molecular interplay peculiar to the orbit appear to provoke the inflammation, fat expansion, and deposition of excessive extracellular matrix molecules in thyroid eye disease. Based upon these new insights, several therapeutic strategies can now be proposed that, for the first time, might specifically interrupt its pathogenesis.

Naik, Vibhavari M; Naik, Milind N; Goldberg, Robert A; Smith, Terry J; Douglas, Raymond S

2009-01-01

197

Presentation of points of general discussion and voting among the speakers of the European Thyroid Association-Cancer Research Network (ETA-CRN) meeting in Lisbon, 2009, entitled "European comments to ATA medullary thyroid cancer guidelines"  

PubMed Central

The main subjects of discussion, held online within the ETA-CRN board invited 16 expert-panelists are shown. The ad hoc emerged ETA-CRN panel of experts (EPE) first congratulated Professor Kloos and the ATA Taskforce for the extensive work on medullary thyroid cancer, and appreciated discussing the ATA guidelines during the ETA-CRN meeting. As it was not possible for all experts to visit the meeting, they enclosed their comments in the online ETA forum. The overall intention was to evaluate certain discrepancies between the ATA guidelines and were biased European clinical practice. All discussants were aware that the ATA guidelines had followed evidence based medicine rules; however, it was intended to reach an European consensus in this matter. The results of online voting among the EPE are shown. We received answers from nine experts. The particular ATA guidelines devoted to the management of MTC ranged in agreement in 0/9 to 4/9. This did not reflect the general, good assessment of the guidelines, as of votes a set of questions. The strongest discrepancies were found in assessment of the usefulness of pentagastrin (Peptavlon®) stimulated calcitonin secretion. The majority of the EPE (5/9) chose an option: “the increase of the basal Ct >100 ng/L means the substantial risk of MTC. However, there should also have been a recommendation for the grey zone 10-100 ng/L, where stimulation with pentagastrin is useful. The cut-off to perform stimulation test at ? 15-20 ng/L and values >100 ng/L means a significant suspicion of MTC”. Similarly, attention from the EPE was raised towards the surgical procedures in MTC, particularly the extent and indications for lymph node surgical intervention. Four questions were related to the indications to lymphadenectomy and extent of surgery. The equal number (4/8) of EPE agreed with the ATA R61 and half of the ETA-CRN panel of experts disagreed because the indications to lymphadenectomy (Lx) depended in their opinion on the tumors detected by the Ct screening, in which prophylactic Lx might not be necessary. “Notwithstanding the evidence based guidelines, their final acceptation requires unrestricted discussion and consideration of differences in clinical practice and experience between countries”.

2013-01-01

198

Digital data from the Questa-San Luis and Santa Fe East helicopter magnetic surveys in Santa Fe and Taos Counties, New Mexico, and Costilla County, Colorado  

USGS Publications Warehouse

This report contains digital data, image files, and text files describing data formats and survey procedures for aeromagnetic data collected during high-resolution aeromagnetic surveys in southern Colorado and northern New Mexico in December, 2005. One survey covers the eastern edge of the San Luis basin, including the towns of Questa, New Mexico and San Luis, Colorado. A second survey covers the mountain front east of Santa Fe, New Mexico, including the town of Chimayo and portions of the Pueblos of Tesuque and Nambe. Several derivative products from these data are also presented as grids and images, including reduced-to-pole data and data continued to a reference surface. Images are presented in various formats and are intended to be used as input to geographic information systems, standard graphics software, or map plotting packages.

Bankey, Viki; Grauch, V. J. S.; Drenth, B. J.; Geophex Ltd.

2006-01-01

199

Dielectric properties and lattice dynamics of Ca-doped K0.95Li0.05TaO3  

NASA Astrophysics Data System (ADS)

Relaxor behavior and lattice dynamics have been studied by employing dielectric measurements and neutron-scattering methods for a single crystal of K1-xLixTaO3 (x=0.05) , where a small amount of a Ca impurity (˜15ppm) was incorporated during the single-crystal growth procedure. The dielectric constant ?'(?,T) shows qualitatively similar behavior to that of Ca-free KLT with x=0.043 with both compositions exhibiting relaxational properties with no evidence for a ferroelectric transition. The absolute value of ?'(?,T=0) for the present crystal is larger by an order of magnitude than that of the Ca-free sample due to charge carriers induced by the Ca doping. This large value is shown to be due to a Maxwell-Wagner relaxation process associated with the low temperature (<8K) activation of frozen electronic carriers. The dielectric loss tangent tan? reveals three Debye-type relaxations with Arrhenius activation energies of 80, 135, and 240meV that are assigned to Li+ dipoles, Ca2+ -related relaxation, and the Li+-Li+ dipolar pairs, respectively. In the neutron scattering results, diffuse scattering ridges appear around the nuclear Bragg peaks along the [100] direction below ˜150K and phonon line broadening features start to appear at even higher temperatures suggesting that polar nanoregions (PNRs) start to form at these temperatures. These results are supported by the dielectric data that reveal relaxor behavior starting at ˜200K on cooling. From analyses of the diffuse intensities at different zones, we have derived atomic displacements in the PNRs. The results suggest that the displacements include a uniform phase shift of all of the atoms in addition to the atomic displacements corresponding to a polarization vector of the transverse-optic soft-ferroelectric-mode, a finding that is analogous to that in the prototypical relaxor material Pb(Mg1/3Nb2/3)O3 .

Wakimoto, S.; Samara, G. A.; Grubbs, R. K.; Venturini, E. L.; Boatner, L. A.; Xu, G.; Shirane, G.; Lee, S.-H.

2006-08-01

200

Late Cenozoic volcanism in the Rio Grande rift: Trace element, strontium isotopic and neodymium isotopic geochemistry of the Taos Plateau volcanics  

SciTech Connect

This thesis evaluates rubidium-strontium and samarium-neodymium isotopic and trace element data for a suite of petrologically diverse continental volcanics from the northern Rio Grande rift of the southwestern US and assesses the role of crustal contamination in generating the observed geochemical variations. Covariations of strontium and neodymium isotopic compositions with rock type suggest the operation of crustal contamination. However, the compositional patterns are too complex to support a simple binary mixing model. Some trace element variations suggest that fractional crystallization has been a significant process in the generation of the sample suite. The preferred, but not unique, model to account for the chemical variations requires contamination of an oceanic-type mantle melt by a partial melt of relatively mafic lower crust. The implications of this analysis for the composition of subcontinental mantle on a regional scale are discussed in light of isotopic studies, both local and global, of other continental volcanics; it is suggested that continental volcanics erupted through thick crust may seldom arrive uncontaminated at the earth's surface. Consequently, subcontinental mantle may be considerably more and less radiogenic in neodymium and strontium, respectively, than the isotopic ratios of continental basalts have led the authors to believe.

Williams, S.

1984-01-01

201

The life of tropical Hot Event in November 2006 (HE0611) observed by advanced satellite sensors and the TAO/TRITON mooring array (Invited)  

NASA Astrophysics Data System (ADS)

We have found Hot Event (HE), which is a short-term (about 20 days) large-scale (about 15x106km2) phenomenon with very high Sea Surface Temperature (SST>30 degC). A HE was identified in the tropical western Pacific in November 2006, which is named HE0611. Two parts (HE0611-East and -West) with very high SST connected to form HE0611. SST in HE0611-West increases quickly with large diurnal SST variations, which is caused by large solar radiation and suppressed latent heat flux. Formation mechanism of HE0611-East is completely different; its very high SST is supported sub-surface high SST anomaly associated with the El Nino. Cloud motion wind and cloud cover data have shown deep convective systems with divergent air flows in HE0611-East. High-level convergence was derived from cloud motion winds over HE0611-West. Cloud-free conditions with convergent flow were considered to be related to the deep convection over HE0611-East. These interactions through the whole troposphere over HE0611 (Figure 1) may have been a true appearance of “remote convection” which has been suggested as a mechanism of very high SST generation in tropical oceans. Using satellite-observed surface winds and atmospheric sounding data, the collapse process of HE0611 is investigated. Sudden strengthening of the subtropical-high-enhanced surface easterly winds moved a deep convective system from HE0611-East to -West. A cloud fraction separated from the moved deep convection may have lifted air parcels for initiation of a new convection system in HE0611-West. A pronounced increase of surface level convective available potential energy (CAPE) and the decrease of convective inhibition indicated enhanced convective instability over HE0611-West. Increases of the mass mixing rate and equivalent potential temperature in the boundary layer were caused by water vapor supply associated with the very high SST in HE0611-West, which enhanced CAPE for the deep convection development. With the development of deep convection over HE0611-West, HE0611 ended when the very high SST was destroyed by increased heat fluxes and enhanced mechanical mixing in the surface layer. Figure 1 Schematic diagram of the interaction between HE0611-West and -East when the deep convective system developed over HE0611-East. Solar radiation and latent heat flux for HE0611-West and -East are listed at the bottom.

Kawamura, H.; Qin, H.

2010-12-01

202

Questa baseline and premining ground-water quality investigation. 8. Lake-sediment geochemical record from 1960 to 2002, Eagle Rock and Fawn Lakes, Taos County, New Mexico  

USGS Publications Warehouse

Geochemical studies of lake sediment from Eagle Rock Lake and upper Fawn Lake were conducted to evaluate the effect of mining at the Molycorp Questa porphyry molybdenum deposit located immediately north of the Red River. Two cores were taken, one from each lake near the outlet where the sediment was thinnest, and they were sampled at 1-cm intervals to provide geochemical data at less than 1-year resolution. Samples from the core intervals were digested and analyzed for 34 elements using ICP-AES (inductively coupled plasma-atomic emission spectrometry). The activity of 137Cs has been used to establish the beginning of sedimentation in the two lakes. Correlation of the geochemistry of heavy-mineral suites in the cores from both Fawn and Eagle Rock Lakes has been used to develop a sedimentation model to date the intervals sampled. The core from upper Fawn Lake, located upstream of the deposit, provided an annual sedimentary record of the geochemical baseline for material being transported in the Red River, whereas the core from Eagle Rock Lake, located downstream of the deposit, provided an annual record of the effect of mining at the Questa mine on the sediment in the Red River. Abrupt changes in the concentrations of many lithophile and deposit-related metals occur in the middle of the Eagle Rock Lake core, which we correlate with the major flood-of-record recorded at the Questa gage at Eagle Rock Lake in 1979. Sediment from the Red River collected at low flow in 2002 is a poor match for the geochemical data from the sediment core in Eagle Rock Lake. The change in sediment geochemistry in Eagle Rock Lake in the post-1979 interval is dramatic and requires that a new source of sediment be identified that has substantially different geochemistry from that in the pre-1979 core interval. Loss of mill tailings from pipeline breaks are most likely responsible for some of the spikes in trace-element concentrations in the Eagle Rock Lake core. Enrichment of Al2O3, Cu, and Zn occurred as a result of chemical precipitation of these metals from ground water upstream in the Red River. Comparisons of the geochemistry of the post-1979 sediment core with both mine wastes and with premining sediment from the vicinity of the Questa mine indicate that both are possible sources for this new component of sediment. Existing data have not resolved this enigma.

Church, S. E.; Fey, D. L.; Marot, M. E.

2005-01-01

203

Open system magnetic evolution of the taos plateau volcanic field, Northern New Mexico. I - The petrology and geochemistry of the servilleta basalt  

NASA Technical Reports Server (NTRS)

MULTIFIT, an embodiment of the conceptual structure needed in modeling multisource and multiprocess magmatic systems, is described. This program, which uses familiar materials balance methodology and the equilibrium form of the Rayleigh equations, links evolutionary arrays, which is turn collectively relate the starting and final compositions of a given magmatic system. Moreover, MULTIFIT incorporates variations within major element data arrays; the linkage between them can be tested using an extension of the least squares algorithm, which selects the best branch point according to the minimum-sum-of-squared-residuals criterion. Advantages and disadvantages of the materials balance approach used in this program are discussed, an example is provided, and equations utilized by MULTIFIT are summarized. While MULTIFIT may not be the best approach for poorly constrained models involving partial melting for complex mixing, it may ultimately prove useful for ascertaining trace element partition coefficients in magnetic systems.

Dungan, M. A.; Lindstrom, M. M.; Mcmillan, N. J.; Moorbath, S.; Hoefs, J.

1986-01-01

204

Optical properties and hydrophilic behaviors of TaO xN y thin films with and without rapid thermal annealing  

Microsoft Academic Search

TaOxNy thin films were prepared using DC reactive sputtering of Ta target with the variation of (O2+N2)\\/Ar ratio, followed by rapid thermal annealing (RTA) at 800 °C for 5 min. During RTA, the amorphous structure of the as-deposited films would transform to crystallized phases that might contain either TaON, or Ta2O5, or both. With the increase of (O2+N2)\\/Ar ratio, Ta2O5 phase becomes

J. H. Hsieh; C. C. Chang; J. S. Cherng; F. Y. Hsu

2009-01-01

205

Residual stress and thermal expansion behavior of TaO xN y films by the micro-cantilever method  

Microsoft Academic Search

A micro-electro–mechanical system (MEMs) technique, the bilayer cantilever beam method was used to examine the residual stress and the thermal expansion coefficient (?) of TaOxNy films by measuring the changes in radius of curvature. Residual stresses of all the TaOxNy films RF-deposited onto SiO2\\/Si (100) are compressive and varied from 2.5 to 12.5 MPa. The compressive stress is inversely proportional

Chao-An Jong; Tsung-Shune Chin; Weileun Fang

2001-01-01

206

Fibroblasts Expressing the Thyrotropin Receptor Overarch Thyroid and Orbit in Graves' Disease  

PubMed Central

Context: Graves' disease (GD) is a systemic autoimmune syndrome comprising manifestations in thyroid and orbital connective tissue. The link between these two tissues in GD eludes our understanding. Patients with GD have increased frequency of circulating monocyte lineage cells known as fibrocytes. These fibrocytes infiltrate orbital connective tissues in thyroid-associated ophthalmopathy and express functional TSH receptor (TSHR). Objective: The aim of the study was to identify and characterize CD34+ fibrocytes in thyroid tissue. Design/Setting/Participants: Patients undergoing surgical thyroidectomy at two academic medical centers were recruited to the study. Main Outcome Measures: We performed immunohistochemistry, flow cytometry, real-time PCR, cytokine-specific ELISA, and cell differentiation. Results: CD34+ColI+CXCR4+TSHR+ cells can be identified in situ in thyroid tissue from donors with GD, Hashimoto's thyroiditis, or in normal-appearing tissue. Thyroid fibroblasts cultivated from these glands express a CD34?ColI+CXCR4+TSHR+ phenotype. TSHR levels are higher than those in orbital fibroblasts. When treated with TSH, thyroid fibroblasts generate IL-6 and IL-8. The induction of IL-6 can be blocked by dexamethasone, a chemical inhibitor of Akt/Pkb, and by knocking down Akt with a specific small interfering RNA. When treated with TGF-? or rosiglitazone, thyroid fibroblasts differentiate into myofibrocytes or adipocytes, respectively. Conclusions: ColI+CXCR4+TSHR+ thyroid fibroblasts resemble orbital fibroblasts and circulating fibrocytes. CD34+ fibrocytes appear to infiltrate both tissues in GD. Thyroid fibroblasts lose CD34 display in culture, unlike orbital fibroblasts and circulating fibrocytes. Fibrocytes and their fibroblast derivatives may participate in the pathogenesis of thyroid autoimmunity after TSHR activation. They could represent a therapeutic target for these diseases.

Padovani-Claudio, Dolly A.; Lu, Ying; Raychaudhuri, Nupur; Fernando, Roshini; Atkins, Stephen; Gillespie, Erin F.; Gianoukakis, Andrew G.; Miller, Barbra S.; Gauger, Paul G.; Doherty, Gerard M.; Douglas, Raymond S.

2011-01-01

207

Solid-State Studies of Oxygen-Deficient Tantalum Pentoxide.  

National Technical Information Service (NTIS)

Although several lower oxides of tantalum -- i.e., Ta4O, Ta2O, TaO, TaO2, TaO sub x (2TaO sub x, could be reproduced in the investigation. Single crystals of composition Ta2O4.73 were prepare...

D. E. Kudrak M. J. Sienko

1966-01-01

208

Radiologic case study. Thyroid acropachy.  

PubMed

Thyroid acropachy is a rare complication of thyroid disease most often occurring in patients with a long history of active Graves' disease with ophthalmopathy and dermopathy already present. It presents with digital clubbing and soft tissue swelling with possible pain in the digits. Plain radiographs show a solid periosteal reaction that tends to be bilateral and generally symmetrical involving the tubular bones of the hands and feet. Treatment is directed at the thyroid dysfunction and the accompanying ophthalmopathy and dermopathy. It is important to recognize the association with a more severe ophthalmopathy. In the absence of Graves' ophthalmopathy and dermopathy, a diligent search for other causes of acropachy is warranted. PMID:18269160

Batal, Omar; Hatem, Stephen F

2008-01-01

209

Experimental and Analytical Study of Thermal Acoustic Oscillations.  

National Technical Information Service (NTIS)

The thermal acoustic oscillations (TAO) data base was expanded by running a large number of tubes over a wide range of parameters known to affect the TAO phenomenon. These parameters include tube length, wall thickness, diameter, material, insertion lengt...

L. W. Spradley W. G. Dean Z. S. Karu

1976-01-01

210

76 FR 76972 - Environmental Impacts Statements; Notice of Availability  

Federal Register 2010, 2011, 2012, 2013

...Guidance for the Management of Public Lands and Resource Administered by Taos Field Office, Colfax, Harding, Los Alamos, Mora, Rio Arriba, Santa Fe, Taos and Union Counties, NM, Review Period Ends: 01/09/2012, Contact: Brad Higdon...

2011-12-09

211

75 FR 33299 - Environmental Impacts Statements; Notice Of Availability  

Federal Register 2010, 2011, 2012, 2013

...Guidance for the Management of Public Lands and Resource Administered by Taos Field Office, Colfax, Harding, Los Alamos, Mora, Rio Arriba, Santa Fe, Taos and Union Counties, NM, Comment Period Ends: 09/08/2010, Contact: Brad Higdon...

2010-06-11

212

Design, Implementation and Operation of a Modular Integrated Tropical Cyclone Hazard Model.  

National Technical Information Service (NTIS)

The Arbiter of Storms (TAOS) is a meteorological hazard model that is integrated, scalable, and modular. It is intended to assist emergency managers, land use planners and meteorologists in assessing the risks associated with meteorological hazards. TAOS ...

C. C. Watson M. E. Johnson

1999-01-01

213

17. Photocopy of architectural drawing (from Albuquerque Area Indian Health ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

17. Photocopy of architectural drawing (from Albuquerque Area Indian Health Service, Division of Health Facilities, Albuquerque, New Mexico) Mayers, Murray, and Phillip, Architects, New York, NY, 1934 Elevations - Taos Indian Health Center, 0.3 mile south-southwest of Pueblos Plaza, Taos Pueblo, Taos County, NM

214

14. Photocopy of architectural drawing (from Albuquerque Area Indian Health ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

14. Photocopy of architectural drawing (from Albuquerque Area Indian Health Service, Division of Health Facilities, Albuquerque, New Mexico) Mayers, Murray, and Phillip, Architects, New York, N&, 1934 Foundation Plan - Taos Indian Health Center, 0.3 mile south-southwest of Pueblos Plaza, Taos Pueblo, Taos County, NM

215

18. Photocopy of architectural drawing (from Albuquerque Area Indian Health ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

18. Photocopy of architectural drawing (from Albuquerque Area Indian Health Service, Division of Health Facilities, Albuquerque, New Mexico) Mayers, Murray, and Phillip, Architects, New York, NY, 1934 Detail sheet - Taos Indian Health Center, 0.3 mile south-southwest of Pueblos Plaza, Taos Pueblo, Taos County, NM

216

16 Photocopy of architectural drawing (from Albuquerque Area Indian Health ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

16 Photocopy of architectural drawing (from Albuquerque Area Indian Health Service, Division of Health Facilities, Albuquerque, New Mexico) Mayers Murray, and Phillip, Architects, New York, NY, 1934 first floor mechanical plan - heating - Taos Indian Health Center, 0.3 mile south-southwest of Pueblos Plaza, Taos Pueblo, Taos County, NM

217

15. Photocopy of architectural drawing (from Albuquerque Area Indian Health ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

15. Photocopy of architectural drawing (from Albuquerque Area Indian Health Service, Division of Health Facilities, Albuquerque, New Mexico) Mayers, Murray, and Phillip, Architects, New York, NY, 1934 First Floor - plumbing - Taos Indian Health Center, 0.3 mile south-southwest of Pueblos Plaza, Taos Pueblo, Taos County, NM

218

A New Generation of Tactical Action Officer Intelligent Tutoring System (ITS)  

Microsoft Academic Search

Stottler Henke is developing for the US Navy's Surface Warfare Officer's School (SWOS) a new generation of Tactical Action Officer (TAO) Intelligent Tutoring System (ITS), interfaced to the Generic Reconfigurable Training System (GRTS). The GRTS TAO ITS allows TAO students to interact naturally using spoken language to command and query simulated entities corresponding to other crew members and off-ship personnel.

Richard Stottler; Susan Panichas

2006-01-01

219

Direct medical cost of pelvic inflammatory disease and its sequelae: decreasing, but still substantial 1 1 The authors thank Anne Haddix, PhD, and Guoyu Tao, PhD, for their methodologic advice  

Microsoft Academic Search

Objective: To estimate direct medical costs and average lifetime cost per case of pelvic inflammatory disease (PID).Methods: We estimated the direct medical expenditures for PID and its three major sequelae (chronic pelvic pain, ectopic pregnancy, and infertility) and determined the average lifetime cost of a case of PID and its sequelae. We analyzed 3 years of claims data of privately

David B Rein; William J Kassler; Kathleen L Irwin; Lara Rabiee

2000-01-01

220

Questa Baseline and Pre-Mining Ground-Water Quality Investigation. 24. Seismic Refraction Tomography for Volume Analysis of Saturated Alluvium in the Straight Creek Drainage and Its Confluence With Red River, Taos County, New Mexico  

USGS Publications Warehouse

As part of a research effort directed by the New Mexico Environment Department to determine pre-mining water quality of the Red River at a molybdenum mining site in northern New Mexico, we used seismic refraction tomography to create subsurface compressional-wave velocity images along six lines that crossed the Straight Creek drainage and three that crossed the valley of Red River. Field work was performed in June 2002 (lines 1-4) and September 2003 (lines 5-9). We interpreted the images to determine depths to the water table and to the top of bedrock. Depths to water and bedrock in boreholes near the lines correlate well with our interpretations based on seismic data. In general, the images suggest that the alluvium in this area has a trapezoidal cross section. Using a U.S. Geological Survey digital elevation model grid of surface elevations of this region and the interpreted elevations to water table and bedrock obtained from the seismic data, we generated new models of the shape of the buried bedrock surface and the water table through surface interpolation and extrapolation. Then, using elevation differences between the two grids, we calculated volumes of dry and wet alluvium in the two drainages. The Red River alluvium is about 51 percent saturated, whereas the much smaller volume of alluvium in the tributary Straight Creek is only about 18 percent saturated. When combined with average ground-water velocity values, the information we present can be used to determine discharge of Straight Creek into Red River relative to the total discharge of Red River moving past Straight Creek. This information will contribute to more accurate models of ground-water flow, which are needed to determine the pre-mining water quality in the Red River.

Powers, Michael H.; Burton, Bethany L.

2007-01-01

221

Treatment of antipsychotic-associated obesity with a GLP-1 receptor agonist--protocol for an investigator-initiated prospective, randomised, placebo-controlled, double-blinded intervention study: the TAO study protocol  

PubMed Central

Introduction Antipsychotic medication is widely associated with dysmetabolism including obesity and type 2 diabetes, cardiovascular-related diseases and early death. Obesity is considered the single most important risk factor for cardiovascular morbidity and mortality. Interventions against antipsychotic-associated obesity are limited and insufficient. Glucagon-like peptide-1 (GLP-1) receptor agonists are approved for the treatment of type 2 diabetes, but their bodyweight-lowering effects have also been recognised in patients with non-diabetes. The primary endpoint of this trial is weight loss after 3?months of treatment with a GLP-1 receptor agonist (exenatide once weekly) in patients with non-diabetic schizophrenia with antipsychotic-associated obesity. Secondary endpoints include physiological and metabolic measurements, various psychopathological and cognitive measures, and structural and functional brain MRI. Methods and analysis 40 obese patients with schizophrenia or schizoaffective disorder treated with antipsychotic drugs will be randomised to subcutaneous injection of exenatide once weekly (2?mg) or placebo for 3?months, adjunctive to their antipsychotic treatment. Ethics and dissemination The trial has been approved by the Danish Health and Medicines Authority, the National Committee on Health Research Ethics and the Danish Data Protection Agency. Trial participation presupposes theoral and written patient informed consent. An external, independent monitoring committee (Good Clinical Practice Unit at Copenhagen University Hospital) will monitor the study according to the GCP Guidelines. Trial data, including positive, negative and inconclusive results, will be presented at national and international scientific meetings and conferences. Papers will be submitted to peer-reviewed journals. Trial registration ClinicalTrials.gov identifier: NCT01794429; National Committee on Health Research Ethics project number: 36378; EudraCT nr: 2012-005404-17; The Danish Data Protection Agency project number: RHP-2012-027.

Ish?y, Pelle L; Knop, Filip K; Broberg, Brian V; Baandrup, Lone; Fagerlund, Birgitte; J?rgensen, Niklas R; Andersen, Ulrik B; Rostrup, Egill; Glenth?j, Birte Y; Ebdrup, Bj?rn H

2014-01-01

222

Questa baseline and pre-mining ground-water quality investigation. 14. Interpretation of ground-water geochemistry in catchments other than the Straight Creek catchment, Red River Valley, Taos County, New Mexico, 2002-2003  

USGS Publications Warehouse

The U.S. Geological Survey, in cooperation with the New Mexico Environment Department, is investigating the pre-mining ground-water chemistry at the Molycorp molybdenum mine in the Red River Valley, New Mexico. The primary approach is to determine the processes controlling ground-water chemistry at an unmined, off-site but proximal analog. The Straight Creek catchment, chosen for this purpose, consists of the same Tertiary-age quartz-sericite-pyrite altered andesite and rhyolitic volcanics as the mine site. Straight Creek is about 5 kilometers east of the eastern boundary of the mine site. Both Straight Creek and the mine site are at approximately the same altitude, face south, and have the same climatic conditions. Thirteen wells in the proximal analog drainage catchment were sampled for ground-water chemistry. Eleven wells were installed for this study and two existing wells at the Advanced Waste-Water Treatment (AWWT) facility were included in this study. Eight wells were sampled outside the Straight Creek catchment: one each in the Hansen, Hottentot, and La Bobita debris fans, four in a well cluster in upper Capulin Canyon (three in alluvial deposits and one in bedrock), and an existing well at the U.S. Forest Service Questa Ranger Station in Red River alluvial deposits. Two surface waters from the Hansen Creek catchment and two from the Hottentot drainage catchment also were sampled for comparison to ground-water compositions. In this report, these samples are evaluated to determine if the geochemical interpretations from the Straight Creek ground-water geochemistry could be extended to other ground waters in the Red River Valley , including the mine site. Total-recoverable major cations and trace metals and dissolved major cations, selected trace metals, anions, alkalinity; and iron-redox species were determined for all surface- and ground-water samples. Rare-earth elements and low-level As, Bi, Mo, Rb, Re, Sb, Se, Te, Th, U, Tl, V, W, Y, and Zr were determined on selected samples. Dissolved organic carbon (DOC), mercury, sulfate stable isotope composition (d34S and d18O of sulfate), stable isotope composition of water (d2H and d18O of water) were measured for selected samples. Chlorofluorocarbons (CFC) and 3He and 3H were measured for age dating on selected samples. Linear regressions from the Straight Creek ground-water data were used to compare ground-water chemistry trends in non-Straight Creek ground waters with Straight Creek alluvial ground-water chemistry dilution trends. Most of the solute trends for the ground waters are similar to those for Straight Creek but there are some notable exceptions. In lithologies that contain substantial pyrite mineralization, acid waters form with similar chemistries to those in Straight Creek and all the waters tend to be calcium-sulfate type. Hottentot ground waters contain substantially lower calcium concentrations relative to those in Straight Creek. This anomaly results from the exposure of rhyolite porphyry in the Hottentot scar and weathering zone. The rhyolite contains less calcium than the altered andesites and tuffs in the Straight Creek catchment and probably does not have the abundant gypsum and calcite. The Hansen ground waters have reached gypsum saturation and have similar calcium, magnesium, and beryllium concentrations as Straight Creek ground waters but have lower concentrations of fluoride, manganese, zinc, cobalt, nickel, copper, and lithium. Lower concentrations of elements related to mineralization at Hansen likely reflect the more distal location of Hansen with respect to intrusive centers that provided the heat source for hydrothermal alteration. The other ground water with water chemistry trends that are outside the Straight Creek trends was from an alluvial well from Capulin Canyon (CC2A). Although it had pH values near 6.0 and most major ions similar to the other Capulin Canyon ground waters, it contained high concentrations

Nordstrom, D. Kirk; McCleskey, R. Blaine; Hunt, Andrew G.; Naus, Cheryl A.

2005-01-01

223

Questa baseline and pre-mining ground-water quality investigation. 20. Water chemistry of the Red River and selected seeps, tributaries, and precipitation, Taos County, New Mexico, 2000-2004  

USGS Publications Warehouse

As part of a multi-year project to infer the pre-mining ground-water quality at Molycorp's Questa mine site, surface-water samples of the Red River, some of its tributaries, seeps, and snow samples were collected for analysis of inorganic solutes and of water and sulfate stable isotopes in selected samples. The primary aim of this study was to document diel, storm event, and seasonal variations in water chemistry for the Red River and similar variations in water chemistry for Straight Creek, a natural analog site similar in topography, hydrology, and geology to the mine site for inferring pre-mining water-quality conditions. Red River water samples collected between 2000 and 2004 show that the largest variations in water chemistry occur during late summer rainstorms, often monsoonal in nature. Within hours, discharge of the Red River increased from 8 to 102 cubic feet per second and pH decreased from 7.80 to 4.83. The highest concentrations of metals (iron, aluminum, zinc, manganese) and sulfate also occur during such events. Low-pH and high-solute concentrations during rainstorm runoff are derived primarily from alteration 'scar' areas of naturally high mineralization combined with steep topography that exposes continually altered rock because erosion is too rapid for vegetative growth. The year 2002 was one of the driest on record, and Red River discharge reflected the low seasonal snow pack. No snowmelt peak appeared in the hydrograph record, and a late summer storm produced the highest flow for the year. Snowmelt was closer to normal during 2003 and demonstrated the dilution effect of snowmelt on water chemistry. Two diel sampling events were conducted for the Red River, one during low flow and the other during high flow, at two locations, at the Red River gaging station and just upstream from Molycorp's mill site. No discernible diel trends were observed except for dissolved zinc and manganese at the upstream site during low flow. Straight Creek drainage water was sampled periodically from 2001 to 2004 at the down stream end of surface drainage near the point at which it disappeared into the debris fan. This water has a minimal range in pH (2.7 to 3.2) but a substantial concentration range in many solutes; for example, sulfate concentrations varied from 525 to 2,660 mg/L. Many elements covary with sulfate suggesting that dilution is the primary control of the range in solute concentrations. A transect of water samples higher in the scar area were collected in October of 2003. They had a lower range in pH (2.44 to 3.05) and higher solute concentrations than those collected periodically from lower in the catchment. Water isotopes for the upper transect samples indicated slight evaporation, and in part, may account for the higher solute concentrations. Drainage waters also were collected from Hottentot, Junebug, Hansen, Little Hansen, and Goat Hill Gulch drainages. Most constituents from other scar drainage waters showed ranges of concentration similar to those of the Straight Creek waters. An exception was water collected from Goat Hill Gulch, which has some of the highest concentrations of any surface-water sample collected but also contained waste-rock leachates.

Verplanck, P. L.; McCleskey, R. B.; Nordstrom, D. K.

2006-01-01

224

Effect of Ta buffer layer and TaO x barrier thickness on the evolution of the structural and magnetic properties of the Fe/TaO x /Co trilayers  

NASA Astrophysics Data System (ADS)

Fe/TaO x /Co trilayers were grown on Si(100)/SiO2 substrates and on tantalum buffer layers by a high vacuum magnetron sputtering system. The effects of both Ta buffer layer and tantalum-oxide barrier layer thickness on the structural and magnetic properties and the coupling of the ferromagnetic layers have been studied. It was observed that Ta improves the structural properties of the Fe layer resulting in an increased coercive field. For a barrier thickness of 4 nm a weak decoupling starts to appear between the ferromagnetic layers and a clear step formation is observed with increasing thickness. The minor hysteresis loops predict an interlayer coupling for thin barriers. The annealing of trilayers up to 250°C shows an increased coercivity for only the Fe layer. Annealing further at 400°C has the opposite effect of decreasing the coercivity, indicating intermixing at the interfaces of the Fe. The refractive index of the insulator barrier shows that the barrier layer is not totally in the form of tantalum-pentoxide.

Tokuc, H.; Tari, S.

2010-01-01

225

Long-term follow-up of ophthalmic Graves' disease.  

PubMed Central

Sixteen patients with ophthalmic Graves' disease (clinically euthyroid with ophthalmopathy or exophthalmos) were followed up for 4.3 to 14.3 (mean 9.1) years to determine whether thyroid dysfunction developed and whether their ophthalmopathy progressed, regressed or remained stable. Five patients (31%) manifested hyperthyroidism or hypothyroidism, all before the end of the fifth year of follow-up. The ophthalmopathy was mild, and none of the patients required specific treatment. The thyroid function of patients with ophthalmic Graves' disease should be periodically monitored for at least 5 years.

Agapitos, P J; Hart, I R

1987-01-01

226

Characterization of a Self-sufficient Trans-Anethole Oxygenase from Pseudomonas putida JYR-1  

PubMed Central

A novel flavoprotein monooxygenase, trans-anethole oxygenase (TAO), from Pseudomonas putida JYR-1, which is capable of catalyzing the oxidation of trans-anethole to p-anisaldehyde, was heterologously expressed in E. coli and purified. Enzymatic kinetics of diverse substrates and cofactors revealed that TAO is likely to be a novel self-sufficient flavoprotein monooxygenase. Enzyme assays of GST-TAO demonstrated that TAO catalyzed a trans-anethole oxidation reaction without auxiliary component enzyme-like electron-transfer flavin reductases. The single component TAO had the ability to reduce flavin cofactors and simultaneously oxidize trans-anthole to p-anisaldehyde. In the processes of reduction of flavin and oxidation of trans-anethole, TAO accepted various flavin and NAD(P)H cofactors. TAO also catalyzed oxidation of isoeugenol, O-methyl isoeugenol, and isosafrole, all of which contain the 2-propenyl functional group on the aromatic ring structure with different catalytic efficiency. TAO had the greatest catalytic efficiency (kcat/Km) with the original substrate, trans-anethole. Investigation about partially deleted mutants of TAO indicated that reductase active sites appeared to be located near the N terminal. Site directed mutagenesis studies also proved that the proposed flavin binding sites, Trp-38, Thr-43, Tyr-55, were critical for flavin reduction. However, disruption of any portion of TAO eliminated the oxygenase activity.

Han, Dongfei; Sadowsky, Michael J.; Chong, Youhoon; Hur, Hor-Gil

2013-01-01

227

Current trends in the management of Graves' disease  

Microsoft Academic Search

Members of the American Thyroid Association were invited to participate in a survey of the management of Graves' disease. One primary case and several variations were provided, which differed in respect to age, sex, goiter size, severity, etc. The questionnaire was based on the format used in a similar survey of members of the European Thyroid Association. The aim of

B. Solomon; D. Glinoer; R. Lagasse; L. Wartofsky

1990-01-01

228

Topical triple-antibiotic ointment as a novel therapeutic choice in wound management and infection prevention: a practical perspective.  

PubMed

Triple-antibiotic ointment (TAO) is a safe and effective topical agent for preventing infections in minor skin trauma. The formulation contains neomycin, polymyxin B and bacitracin in a petrolatum base. TAO is active against the most common disease-causing pathogens found in wounds and on the skin and may be an attractive alternative to oral therapy in select circumstances. Resistance to TAO does not develop readily, and safety studies have shown that the risk of allergic sensitivity to TAO is low. Susceptibility profiles of TAO have remained relatively unchanged since its discovery. Prophylaxis or treatment with TAO should be considered as resistant organisms continue to emerge in the community and hospital setting. PMID:17914912

Bonomo, Robert A; Van Zile, Peter S; Li, Qing; Shermock, Kenneth M; McCormick, William G; Kohut, Bruce

2007-10-01

229

Thyroid dermopathy and acropachy.  

PubMed

Graves' disease is an autoimmune condition commonly associated with thyroid dysfunction and with anti-thyroid antibodies, usually TSH receptor stimulating antibodies. Thyroid autoimmunity also may be associated with extra thyroidal manifestations. Most common extra thyroidal manifestation is ophthalmopathy. Less common is thyroid dermopathy, usually occurring in pretibial area. Dermopathy is almost always associated with ophthalmopathy and in severe cases with acropachy. A common antigen with thyroid in tissues of the skin and the eyes, most likely TSH receptor, is involved in pathogenesis of extra thyroidal manifestations. Presence of dermopathy and acropachy are predictors of severity of autoimmune process. Local corticosteroid application is the standard therapy for dermopathy. Response to therapy is good in mild cases and poor in severe cases. Immune modulators and biotherapies are undergoing randomized trials for ophthalmopathy component of Graves' disease. Any therapy proven to be effective for ophthalmopathy can be utilized in future for management of dermopathy. PMID:22863396

Fatourechi, Vahab

2012-08-01

230

Troleandomycin effects on methylprednisolone and methylprednisone interconversion and disposition in the rabbit  

Microsoft Academic Search

Summary  A study of the effects of troleandomycin (TAO) on the disposition of intravenous methylprednisolone in rabbits was performed\\u000a in order to develop an animal model to further evaluate the mechanism of TAO\\/steroid beneficial effects in severe asthma.\\u000a The plasma concentration-time profiles of methylprednisolone and methylprednisone were determined in the presence and absence\\u000a of single and multiple dose TAO regimens. Pharmacokinetic

William F. Ebling; Steven A. Rich; William J. Jusko

1987-01-01

231

Extrathyroidal complications of Graves' disease.  

PubMed

Ophthalmopathy, pretibial myxoedema and acropachy are progressively less common features of Graves' disease with unknown but probably related aetiologies (Table 1). Treatment for affected eyes and skin is unsatisfactory and will only improve when we understand the pathogenesis of these complications and their arcane relationship with thyroid autoimmunity. This brief review will highlight recent research which suggests that fibroblast activation is critical to the appearance of ophthalmopathy and dermopathy; more general overviews can be found elsewhere. PMID:7692461

Weetman, A P

1993-08-01

232

[A rare hyperthyroid syndrome].  

PubMed

The exophthalmos, myxedema, acropachy (EMA) syndrome is a rare extrathyroid syndrome, interesting about 1% of the patients affected by extrathyroid complications of Graves' disease. The ratio female/male is 3.4:1 and this case report is very rare. The patient, a 52-year-old man, presented a serious ophthalmopathy with pretibial myxedema, acropachy with joint pain. The triad manifested itself after some ophthalmopathy treatments, i.e. total thyroidectomy, steroidal retrobulbar therapy and radiotherapy. The patient received T4 therapy and the thyroid function status was normal. The appearance of the EMA syndrome coincided with the fast worsening of the ophthalmopathy. This case report confirms previous observations regarding the chronological sequence of presentations of extrathyroidal manifestations of autoimmune thyroid disease. The thyroid disease develops first, followed by ophthalmopathy, then dermopathy, and finally, acropachy. The thyroid acropachy shows some differences between pulmonary and paraneoplastic osteoarthropathy, due to the presence of thyroid dermopathy and ophtalmopathy (EMA) and to the different subperiosteal proliferation. Steroidal therapy improved the ophthalmopathy, the pretibial myxedema and the acropachy. The improvement obtained has been faster as regards the exophtalmos and myxedema, slower as regards the acropachy, but of the same importance. In conclusion, acropachy is the latest manifestation of EMA and coincides with the worsening of ophthalmopathy. The traditional steroidal therapy is effective to improve the syndrome. PMID:15257258

Artuso, V; Roiter, I

2004-06-01

233

Can Expert System Help Train Tactical Action Officers: Some Experiences from an Early Prototype.  

National Technical Information Service (NTIS)

The variety and complexity of modern weapon systems demands great skill on the part of the Tactical Action Officers (TAOs) in correctly analyzing the threat, and taking appropriate countermeasures, during a naval engagement. Not only do the TAOS need to h...

Zivovic

1986-01-01

234

Rio Grande Corridor Final Plan.  

National Technical Information Service (NTIS)

This document is the final version of the Rio Grande Corridor Plan, which provides management guidance for public lands along the Rio Grande in New Mexico (Taos Field Office) and in Colorado (La Jara Field Office) and amends the Taos Resource Management P...

2000-01-01

235

Contemporary antimicrobial activity of triple antibiotic ointment: a multiphased study of recent clinical isolates in the United States and Australia  

Microsoft Academic Search

Triple antibiotic ointment (TAO) containing neomycin, polymyxin B, and bacitracin was launched in the 1950s in the United States (USA) as a prescription product and then was used over the counter (OTC) since the 1970s (USA) to prevent superficial wound infections. In Australia, TAO has been restricted to prescription use. This study 1) determined cross-resistance patterns of neomycin compared with

Ronald N. Jones; Qing Li; Bruce Kohut; Douglas J. Biedenbach; Jan Bell; John D. Turnidge

2006-01-01

236

Turning Patrons into Partners When Choosing an Integrated Library System  

ERIC Educational Resources Information Center

UCLA, which has one of the top 10 research libraries in the country, has been using Taos software since 1996. However in 2001, Sirsi Corp. announced that it was freezing development on Taos software. As the associate university librarian for information technology at UCLA, the author relates that it was his responsibility to lead the way through…

Ryan, Terry

2004-01-01

237

Comment on “Magnetostratigraphic study of the Kuche Depression, Tarim Basin, and Cenozoic uplift of the Tian Shan Range, Western China” Baochun Huang, John D.A. Piper, Shoutao Peng, Tao Liu, Zhong Li, Qingchen Wang, Rixiang Zhu [Earth Planet. Sci. Lett., 2006, doi:10.1016/j.epsl.2006.09.020  

NASA Astrophysics Data System (ADS)

The recent publication of "Magnetostratigraphic study of the Kuche Depression, Tarim Basin, and Cenozoic uplift of the Tian Shan Range,Western China" by B.C. Huang, J.D.A. Piper, S.T. Peng, T. Liu, Z. Li, Q.C. Wang, R.X. Zhu [Earth Planet. Sci. Lett., 2006, doi:10.1016/j.epsl.2006.09.020] discusses the Cenozoic uplift history of the Tianshan Mountains by studying the magnetostratigraphy of Paleogene to Neogene continental sediments from two sections located in the Kuche basin at the northern edge of the Tarim basin. To support their conclusion they reinterpreted a magnetostratigraphic study of the Yaha section, which lies ~ 10 km south of their sections, we previously published [J. Charreau, S. Gilder, Y. Chen, S. Dominguez, J.-P. Avouac, S. Sen, M. Jolivet, Y. Li and W. Wang, Magnetostratigraphy of the Yaha section, Tarim Basin (China): 11 Ma acceleration in erosion and uplift of the Tianshan Mountains, Geology 34(3), 2006, 181­184.]. Here, (1) we argue that the interpretations of the sedimentation rate changes they proposed for the Kuche sections are partially invalid, (2) we disagree with their reinterpretation of the age of the Yaha section, and (3) we think that the way they interpret their AMS data is incorrect.

Charreau, Julien; Chen, Yan; Gilder, Stuart; Barier, Laurie

2008-04-01

238

Find an Endocrinology - Thyroid Specialist  

MedlinePLUS

... Thyroid Information > Find an Endocrinology – Thyroid Specialist Find an Endocrinology – Thyroid Specialist Please tell your thyroidologist that ... is not, and does not intend to be, an endorsement by the American Thyroid Association of the ...

239

X-ray absorption, photoemission spectroscopy, and Raman scattering analysis of amorphous tantalum oxide with a large extent of oxygen nonstoichiometry.  

PubMed

The electronic structure and modification of the local interatomic structure of a reactive sputtered amorphous tantalum oxide (a-TaO(x)) thin film with the variation of oxygen nonstoichiometry, x in a-TaO(x) have been investigated by X-ray absorption spectroscopy (XAS), X-ray photoemission spectroscopy (XPS), Raman scattering spectroscopy, and Rutherford back scattering spectroscopy. A parallel chemical shift of Ta4f(7/2) and O1s core levels observed with the variation of x indicates the Fermi level shift by reduction and oxidation in the framework of the rigid band model. Extended X-ray absorption fine structure (EXAFS) suggests both the increase of average coordination number of the first Ta-O shell in polyhedra and a considerable reduction of the average Ta-O bond length with the increase of x. The relative intensity of Raman shift peaks at 670 cm(-1) and 815 cm(-1), corresponding to Ta-O stretching of TaO(6) octahedra and TaO(5) probably with a pyramidal form, respectively, drastically changes between x = 2.47 to 1.86, suggesting the change in the predominant polyhedron from TaO(6) to TaO(5) with a modification in multiplicity of oxygen by the reorganization of the polyhedral network. PMID:21863188

Tsuchiya, Takashi; Imai, Hideto; Miyoshi, Shogo; Glans, Per-Anders; Guo, Jinghua; Yamaguchi, Shu

2011-10-14

240

Investigation of the expression of mediators of neovascularization from mononuclear leukocytes in thromboangiitis obliterans.  

PubMed

The aim of this study was to investigate the expression of the cytokines, chemokines and effective molecules of peripheral blood mononuclear cells (PBMCs) that play a role in neovascularization in thromboangiitis obliterans (TAO). Lymphocytes from TAO patients (n = 20) and control subjects (healthy smokers [n = 16] and non-smokers [n = 17]) were evaluated using realtime polymerase chain reaction in order to examine the mRNA expression of CXCL1 and interleukin 8 (IL-8; inducers of collateral development by recruitment of circulating progenitor cells [CPCs]), endothelial cell growth factor A (VEGF-A) and inducible nitric oxide synthase (iNOS; inducers of angiogenesis) and interferon gamma (IFN-?) and vascular endothelial growth factor receptor 1 (VEGFR-1; inhibitors of angiogenesis). CXCL1 expression was significantly higher in the TAO patients than control subjects. The expressions of IL-8, VEGFR-1 and IFN-? were significantly higher in the TAO patients and smokers than in non-smokers. However, no differences in iNOS and VEGF-A expression were noted. In conclusion, PBMCs from TAO patients expressed cytokines that potentially recruit CPCs and promote arteriogenesis. However, TAO patients typically have low CPC levels, perhaps due to high oxidative stress. Further studies are recommended in order to investigate the efficacy of antioxidant therapy on the outcome of TAO before administration of angiogenic factors. PMID:23567329

Fazeli, Bahare; Rafatpanah, Houshang; Ravari, Hassan; Hosseini, Reza Farid; Rezaee, S A Rahim

2013-04-01

241

Thermally-assisted-occupation density functional theory with generalized-gradient approximations  

NASA Astrophysics Data System (ADS)

We extend the recently proposed thermally-assisted-occupation density functional theory (TAO-DFT) [J.-D. Chai, J. Chem. Phys. 136, 154104 (2012)] to generalized-gradient approximation (GGA) exchange-correlation density functionals. Relative to our previous TAO-LDA (i.e., the local density approximation to TAO-DFT), the resulting TAO-GGAs are significantly superior for a wide range of applications, such as thermochemistry, kinetics, and reaction energies. For noncovalent interactions, TAO-GGAs with empirical dispersion corrections are shown to yield excellent performance. Due to their computational efficiency for systems with strong static correlation effects, TAO-LDA and TAO-GGAs are applied to study the electronic properties (e.g., the singlet-triplet energy gaps, vertical ionization potentials, vertical electron affinities, fundamental gaps, and symmetrized von Neumann entropy) of acenes with different number of linearly fused benzene rings (up to 100), which is very challenging for conventional electronic structure methods. The ground states of acenes are shown to be singlets for all the chain lengths studied here. With the increase of acene length, the singlet-triplet energy gaps, vertical ionization potentials, and fundamental gaps decrease monotonically, while the vertical electron affinities and symmetrized von Neumann entropy (i.e., a measure of polyradical character) increase monotonically.

Chai, Jeng-Da

2014-05-01

242

Thermally-assisted-occupation density functional theory with generalized-gradient approximations.  

PubMed

We extend the recently proposed thermally-assisted-occupation density functional theory (TAO-DFT) [J.-D. Chai, J. Chem. Phys. 136, 154104 (2012)] to generalized-gradient approximation (GGA) exchange-correlation density functionals. Relative to our previous TAO-LDA (i.e., the local density approximation to TAO-DFT), the resulting TAO-GGAs are significantly superior for a wide range of applications, such as thermochemistry, kinetics, and reaction energies. For noncovalent interactions, TAO-GGAs with empirical dispersion corrections are shown to yield excellent performance. Due to their computational efficiency for systems with strong static correlation effects, TAO-LDA and TAO-GGAs are applied to study the electronic properties (e.g., the singlet-triplet energy gaps, vertical ionization potentials, vertical electron affinities, fundamental gaps, and symmetrized von Neumann entropy) of acenes with different number of linearly fused benzene rings (up to 100), which is very challenging for conventional electronic structure methods. The ground states of acenes are shown to be singlets for all the chain lengths studied here. With the increase of acene length, the singlet-triplet energy gaps, vertical ionization potentials, and fundamental gaps decrease monotonically, while the vertical electron affinities and symmetrized von Neumann entropy (i.e., a measure of polyradical character) increase monotonically. PMID:24832329

Chai, Jeng-Da

2014-05-14

243

Alternative oxidase present in procyclic Trypanosoma brucei may act to lower the mitochondrial production of superoxide.  

PubMed

The mitochondrial electron transfer chain present in the procyclic form of the African trypanosome Trypanosoma brucei contains both cytochrome c oxidase and an alternative oxidase (TAO) as terminal oxidases that reduce oxygen to water. By contrast, the electron transfer chain of the primitive mitochondrion present in the bloodstream form of T. brucei contains only TAO as the terminal oxidase. TAO functions in the bloodstream forms to oxidize the ubiquinol produced by the glycerol-3-phosphate shuttle that results in the oxidation of the reduced nicotinamide adenine dinucleotide phosphate produced by glycolysis. The function, however, of TAO in the procyclic forms is unknown. In this study, we found that inhibition of TAO by the specific inhibitor salicylhydroxamic acid stimulates the formation of reactive oxygen species (ROS) in trypanosome mitochondria, resulting in mitochondrial alteration and increased oxidation of cellular proteins. Moreover, the activity and protein content of TAO in procyclic trypanosomes were increased when cells were incubated in the presence of hydrogen peroxide or antimycin A, the cytochrome bc1 complex inhibitor, which also results in increased ROS production. We suggest that one function of TAO in procyclic cells may be to prevent ROS production by removing excess reducing equivalents and transferring them to oxygen. PMID:12781782

Fang, Jing; Beattie, Diana S

2003-06-15

244

Thermal stability and electrical properties of titanium-aluminum oxide ultrathin films as high-k gate dielectric materials  

Microsoft Academic Search

As potential high-k gate dielectric material for metal-oxide-semiconductor field effect transistor, the TiO2 incorporated Al2O3 [(TiO2)x(Al2O3)1-x (TAO)] films have been prepared by pulsed laser deposition. The thermal stability and electrical properties of the TAO films annealed at different temperatures have been systematically investigated by x-ray photoelectron spectroscopy, high-resolution transmission electron microscopy, and capacitance-voltage measurements. These results show that the TAO

L. Shi; Y. D. Xia; B. Xu; J. Yin; Z. G. Liu

2007-01-01

245

International Time Comparison by a GPS (Global Positioning System) Timing Receiver.  

National Technical Information Service (NTIS)

Tokyo Astronomical Observatory (TAO) has started a regular reception of the Global Positioning System (GPS) timing signals for the purpose of a precise international time comparison. A test operation of the GPS receiver was performed from September 1982 t...

M. K. Fujimoto K. Fujiwara S. Aoki

1984-01-01

246

40 CFR Appendix Vi to Part 264 - Political Jurisdictions 1 in Which Compliance With § 264.18(a) Must Be Demonstrated  

Code of Federal Regulations, 2010 CFR

...Teton Wheatland Nevada All New Mexico Bernalillo Catron Grant Hidalgo Los Alamos Rio Arriba Sandoval Sante Fe Sierra Socorro Taos Torrance Valencia Utah Beaver Box Elder Cache Carbon Davis Duchesne Emery...

2009-07-01

247

40 CFR Appendix Vi to Part 264 - Political Jurisdictions 1 in Which Compliance With § 264.18(a) Must Be Demonstrated  

Code of Federal Regulations, 2010 CFR

...Teton Wheatland Nevada All New Mexico Bernalillo Catron Grant Hidalgo Los Alamos Rio Arriba Sandoval Sante Fe Sierra Socorro Taos Torrance Valencia Utah Beaver Box Elder Cache Carbon Davis Duchesne Emery...

2010-07-01

248

77 FR 37941 - Order Granting a Limited Exemption From Exchange Act Rule 10b-17 to Certain Actively Managed...  

Federal Register 2010, 2011, 2012, 2013

...Return Exchange-Traded Fund (March 1, 2012) and Letter from Josephine J. Tao, Assistant Director to Jack P. Drogin, Schiff Hardin regarding WisdomTree Emerging Markets Corporate Bond Fund (April 16,...

2012-06-25

249

Miscellaneous Papers Numbers 13-21.  

National Technical Information Service (NTIS)

Nine papers are included on various archeological topics in New Mexico and Arizona. Coverage includes site survey in the Mt. Taylor area, lithic analysis from the Mimbres, survey and burial data from near Taos and excavations near Vosburg, Arizona.

D. F. Green

1978-01-01

250

Proof mining in metric fixed point theory and ergodic theory  

Microsoft Academic Search

In this survey we present some recent applications of proof mining to the fixed point theory of (asymptotically) nonexpansive mappings and to the metastability (in the sense of Terence Tao) of ergodic averages in uniformly convex Banach spaces.

Laurentiu Leustean

2009-01-01

251

40 CFR Appendix III to Part 1068 - High-Altitude Counties  

Code of Federal Regulations, 2010 CFR

...Bernalillo Catron Colfax Curry De Baca Grant Guadalupe Harding Hidalgo Lincoln Los Alamos Luna McKinley Mora Otero Rio Arriba Roosevelt Sandoval San Juan San Miguel Santa Fe Sierra Socorro Taos Torrance Union...

2010-07-01

252

76 FR 35935 - New Mexico Disaster #NM-00019 Declaration of Economic Injury  

Federal Register 2010, 2011, 2012, 2013

...Counties: Bernalillo, Lincoln, Taos. Contiguous Counties: New Mexico: Chaves, Cibola, Colfax, De Baca, Guadalupe, Mora, Otero, Rio Arriba, Sandoval, Santa Fe, Sierra, Socorro, Torrance, Valencia. Colorado: Conejos, Costilla. The...

2011-06-20

253

Challenging, Complementing or Assuming 'the Mandate of Heaven'? Political Distrust and the Rise of Self-Governing Social Organizations in Rural China  

Microsoft Academic Search

Pesqué-Cela, Vanesa, Tao, Ran, Liu, Yongdong, and Sun, Laixiang—Challenging, comple- menting or assuming 'the Mandate of Heaven'? Political distrust and the rise of self- governing social organizations in rural China

Vanesa Pesqué-Cela; Ran Tao; Yongdong Liu; Laixiang Sun

2008-01-01

254

Solar Heating and Hot Water System Installed at St. Louis, Missouri. Final Report.  

National Technical Information Service (NTIS)

Information is provided on the solar heating and hot water system installed at the William Tao and Associates, Inc., office building in St. Louis, Missouri. The information consists of description, photos, maintenance and construction problems, final draw...

1980-01-01

255

78 FR 72919 - New Mexico; Amendment No. 1 to Notice of a Major Disaster Declaration  

Federal Register 2010, 2011, 2012, 2013

...President in his declaration of October 29, 2013. De Baca, Dona Ana, Harding, Lincoln, Otero, Rio Arriba, and San Juan Counties and Isleta, Sandia, and Taos Pueblos and the Navajo Nation for Public Assistance. The following Catalog of...

2013-12-04

256

El Nino Zoom to Cross-section of Temperature and Height Anomalies: June 1997 through June 1998  

NSDL National Science Digital Library

An animation of sea surface temperature anomaly, sea surface height anomaly, and sea temperature anomaly at depth in the Pacific Ocean from June 1997 through June 1998 as measured by NOAA AVHRR, TOPEX Poseidon, and the TAO TRITON Array

Shirah, Greg; Busalacchi, Antonio

1998-06-11

257

El Nino Zoom to Cross-section of Temperature and Height Anomalies: September 1997 through July 1998  

NSDL National Science Digital Library

An animation of sea surface temperature anomaly, sea surface height anomaly, and sea temperature anomaly at depth in the Pacific Ocean from September 1997 through July 1998 as measured by NOAA AVHRR, TOPEX Poseidon, and the TAO TRITON Array

Shirah, Greg; Busalacchi, Antonio

1998-07-01

258

El Nino-La Nina Zoom to Cross-section of Temperature and Height Anomalies: Jan. 1997 through Nov. 1998  

NSDL National Science Digital Library

An animation of sea surface temperature anomaly, sea surface height anomaly, and sea temperature anomaly at depth in the Pacific Ocean from January 1997 through November 1998 as measured by NOAA AVHRR, TOPEX Poseidon, and the TAO TRITON Array

Shirah, Greg; Busalacchi, Antonio

1998-11-23

259

El Nino Zoom to Cross-section of Sea Temperature and Height: January 1997 through March 1998  

NSDL National Science Digital Library

An animation of sea surface temperature, sea surface height, and sea temperature at depth in the Pacific Ocean from January 1997 through March 1998 as measured by NOAA AVHRR, TOPEX Poseidon, and the TAO TRITON Array

Shirah, Greg; Busalacchi, Antonio

1998-03-20

260

El Nino-La Nina Cross-section of Temperature and Height Anomalies: January 1997 through March 1999  

NSDL National Science Digital Library

An animation of sea surface temperature anomaly, sea surface height anomaly, and sea temperature anomaly at depth in the Pacific Ocean from January 1997 through March 1999 as measured by NOAA AVHRR, TOPEX Poseidon, and the TAO TRITON Array

Shirah, Greg; Busalacchi, Antonio

1999-04-01

261

El Nino Zoom to Cross-section of Temperature and Height Anomalies: August 1997 through August 1998  

NSDL National Science Digital Library

An animation of sea surface temperature anomaly, sea surface height anomaly, and sea temperature anomaly at depth in the Pacific Ocean from August 1997 through August 1998 as measured by NOAA AVHRR, TOPEX Poseidon, and the TAO TRITON Array

Shirah, Greg; Busalacchi, Antonio

1998-08-01

262

El Nino Zoom to Cross-section of Temperature and Height Anomalies: July 1997 through August 1998  

NSDL National Science Digital Library

An animation of sea surface temperature anomaly, sea surface height anomaly, and sea temperature anomaly at depth in the Pacific Ocean from July 1997 through August 1998 as measured by NOAA AVHRR, TOPEX Poseidon, and the TAO TRITON Array

Shirah, Greg; Busalacchi, Antonio

1998-08-20

263

El Nino-La Nina Cross-section of Temperature and Height Anomalies: Jan. 1997 through Febr. 1999  

NSDL National Science Digital Library

An animation of sea surface temperature anomaly, sea surface height anomaly, and sea temperature anomaly at depth in the Pacific Ocean from January 1997 through February 1999 as measured by NOAA AVHRR, TOPEX Poseidon, and the TAO TRITON Array

Shirah, Greg; Busalacchi, Antonio

1999-04-01

264

El Nino-La Nina Cross-section of Temperature and Height Anomalies: Jan. 1997 through Dec. 1999  

NSDL National Science Digital Library

An animation of sea surface temperature anomaly, sea surface height anomaly, and sea temperature anomaly at depth in the Pacific Ocean from January 1997 through December 1999 as measured by NOAA AVHRR, TOPEX Poseidon, and the TAO TRITON Array

Shirah, Greg; Busalacchi, Antonio

1999-12-21

265

El Nino-La Nina Cross-section of Temperature and Height Anomalies: Jan. 1997 through Nov. 1998  

NSDL National Science Digital Library

An animation of sea surface temperature anomaly, sea surface height anomaly, and sea temperature anomaly at depth in the Pacific Ocean from July 1997 through November 1998 as measured by NOAA AVHRR, TOPEX Poseidon, and the TAO TRITON Array

Shirah, Greg; Busalacchi, Antonio

1998-11-23

266

El Nino-La Nina Cross-section of Sea Temperature and Height: July 1997 through November 1998  

NSDL National Science Digital Library

An animation of sea surface temperature, sea surface height, and sea temperature at depth in the Pacific Ocean from July 1997 through November 1998 as measured by NOAA AVHRR, TOPEX Poseidon, and the TAO TRITON Array

Shirah, Greg; Busalacchi, Antonio

1998-11-23

267

El Nino Zoom to Cross-section of Temperature and Height Anomalies: July 1997 through October 1998  

NSDL National Science Digital Library

An animation of sea surface temperature anomaly, sea surface height anomaly, and sea temperature anomaly at depth in the Pacific Ocean from July 1997 through October 1998 as measured by NOAA AVHRR, TOPEX Poseidon, and the TAO TRITON Array

Shirah, Greg; Busalacchi, Antonio

1998-10-26

268

Renal and hepatic family 3A cytochromes P450 (CYP3a) in spontaneously hypertensive rats  

Microsoft Academic Search

Troleandomycin (TAO), a selective family 3A cytochromes P450 (CYP3A) inhibitor, decreases enhanced in vivo corticosterone 6?-hydroxylation and blood pressure in spontaneously hypertensive rats (SHR). Corticosterone 6?-hydroxylation was measured in liver and kidney microsomes, to determine ontogeny and the effect of TAO on CYP3A activity at the organ level. SHR kidney CYP3A activity increased from 4 to 8 weeks, stabilized at

Sidhartha S. Ghosh; Ashish K. Basu; Shobha Ghosh; Rodney Hagley; Lora Kramer; John Schuetz; W. McLean Grogan; Philip Guzelian; Charles O. Watlington

1995-01-01

269

A procedure for determination of cobalt in water samples after dispersive liquid–liquid microextraction  

Microsoft Academic Search

In this work, a procedure for preconcentration of cobalt using dispersive liquid–liquid microextraction (DLLME) with the reagent Br-TAO as complexing reagent was developed. The procedure is based on a ternary system of solvents, where appropriate amounts of the extraction solvent, disperser solvent and the chelating agent Br-TAO are directly injected into an aqueous solution containing Co(II). A cloudy mixture is

Patrícia Xavier Baliza; Leonardo Sena Gomes Teixeira; Valfredo Azevedo Lemos

2009-01-01

270

The relationship between adsorption of heavy metal and organic matter in river sediments  

Microsoft Academic Search

Sediment samples of eight sites in two rivers located in northern Taiwan, the Tao-Chen River and the Lau-Che River, were collected to investigate the influences of organic matter on adsorbabilities of heavy metals in dry and wet periods. A batch scale adsorption study was conducted to examine the adsorbabilities of heavy metals of sediments. In the less polluted river (Tao-Chen

Jih-Gaw Lin; Shen-Yi Chen

1998-01-01

271

Thyroid Acropachy: Report of 40 Patients Treated at a Single Institution in a 26Year Period  

Microsoft Academic Search

Thyroid acropachy is an extreme manifestation of autoim- mune thyroid disease. It presents with digital clubbing, swell- ing of digits and toes, and periosteal reaction of extremity bones. It is almost always associated with ophthalmopathy and thyroid dermopathy. During a 26-yr period at our insti- tution, of 178 patients with thyroid dermopathy, 40 had ac- ropachy. Clubbing associated with thyroid

VAHAB FATOURECHI; DEBRA D. F. AHMED; KARA M. SCHWARTZ

272

Triad of exophthalmos, pretibial myxedema, and acropachy in a patient with Graves' disease  

Microsoft Academic Search

Graves' disease is an autoimmune disorder of the thyroid gland with characteristic peripheral manifestations. The most common clinical findings include ophthalmopathy in 30% of patients, dermopathy (pretibial myxedema) in 4% of patients, and thyroid acropachy in 1% of patients. The triad of exophthalmos, pretibial myxedema, and acropachy occurs in less than 1% of patients. We present a case of Graves'

Christina K. Anderson; O. Fred Miller

2003-01-01

273

Smoking and thyroid disorders--a meta-analysis  

Microsoft Academic Search

Background: Smoking has been associated with Graves' disease, but it remains unclear if the association is present in other thyroid disorders. Outcome variables: Graves' disease, Graves' ophthalmopathy, toxic nodular goitre, non-toxic goitre, post-partum thyroid disease, Hashimoto's thyroiditis, or hypothyroidism. Material and methods: A search of MEDLINE identified 25 studies on the association between smoking and thyroid diseases. Results: In Graves'

Peter Vestergaard

2002-01-01

274

Colchicina no tratamento da fase inflamatória da oftalmopatia de Graves: um estudo prospectivo e randomizado com prednisona  

Microsoft Academic Search

Purpose: To investigate if colchicine is valuable in the treatment of Graves' ophthalmopathy (GO), we compared its effect with prednisone in 22 patients during the inflammatory phase of GO. Methods: All patients, similar in age, sex and smoking habits, were euthyroid for at least 3 months and randomly divided into two groups, one treated with colchicine (1.5 mg\\/day) and the

Paulo Gois Manso; Ângela Maria Borri Wolosker; Elias Rodrigues de Paiva; Antonio Carlos Lopes; Reinaldo Perrone Furlanetto

275

Decompression of endocrine orbitopathy via an extended extradural pterional approach  

Microsoft Academic Search

Summary. Background. Numerous surgical decompression techniques have been described in endocrine orbitopathy. We present an overview of the treatment and clinical outcome of 13 patients with endocrine ophthalmopathy and 20 orbital decompressions via an extradural pterional approach, carried out in our center from 1995 to 2002. Method. Decompression of the antero- and posterolateral wall, of the roof, and the superior

U. Schick; W. Hassler

2005-01-01

276

Necrotizing scleritis after strabismus surgery in thyroid eye disease.  

PubMed

Surgically induced necrotizing scleritis, which can lead to potentially devastating consequences, is a rare sequela to many types of ocular surgeries. We describe a 58-year-old woman who developed necrotizing scleritis following strabismus surgery for thyroid ophthalmopathy. Tectonic corneal patch grafting resulted in a favorable outcome. PMID:24160978

Huang, Chung-Ying; Lin, Hsin-Chiung; Yang, Meng-Ling

2013-10-01

277

Pretibial myxedema: pathophysiology and treatment options.  

PubMed

Pretibial myxedema or localized myxedema or thyroid dermopathy is an autoimmune manifestation of Graves' disease. It also occasionally occurs in Hashimoto's thyroiditis. Lesions of thyroid dermopathy are usually asymptomatic and have only cosmetic importance. Advanced forms of dermopathy are associated with elephantiasis or thyroid acropachy. Almost all cases of thyroid dermopathy are associated with relatively severe ophthalmopathy. Usually ophthalmopathy appears first and dermopathy much later. All patients with localized myxedema have high serum concentrations of thyroid-stimulating hormone receptor antibodies, indicating the severity of the autoimmune condition. Occurrence of thyroid dermopathy in areas other than pretibial skin indicates a systemic process. Similar to Graves' ophthalmopathy, thyroid-stimulating hormone receptors in the connective tissue may be the antigen responsible for the immune process. Both humoral and cellular immune mechanisms are involved in the stimulation of fibroblasts and the production of large amounts of glycosaminoglycans. Localization in the pretibial area relates to mechanical factors and dependent position. Diagnosis of thyroid dermopathy is based on signs and typical pretibial skin lesions in association with a history of Graves' hyperthyroidism and ophthalmopathy. In some cases, skin biopsy is needed for confirmation. The lesions are usually mild and are overshadowed by more symptomatic ophthalmopathy. Most cases of thyroid dermopathy do not require any therapy. In mildly severe symptomatic cases and when there is cosmetic concern, topical corticosteroids applied under occlusive dressing are beneficial. In more severe cases, systemic immunomodulation may be necessary; however, conclusive evidence for long-term efficacy of these modalities is lacking. When significant edema and elephantiasis are present, local compressive therapy may have added benefit. In mild cases that do not require treatment, 50% of patients achieve complete remission after several years. Severe cases that receive topical corticosteroids or other therapies do not have a better outcome than untreated milder cases. Current treatment modalities for thyroid dermopathy and acropachy are at best palliative. Better and safer means of immunomodulation are needed. PMID:16252929

Fatourechi, Vahab

2005-01-01

278

Ophthalmic Manifestations of Leukemia in a Tertiary Hospital Population of Adult Nigerian Africans  

PubMed Central

Purpose: To determine the prevalence and pattern of leukemic ophthalmopathy among adults at the University of Nigeria Teaching Hospital (UNTH), Enugu, south-eastern, Nigeria. Materials and Methods: This prospective, observational case series surveyed adult leukemia patients presenting at UNTH’s departments of Hematology/Immunology and Ophthalmology from July 2003 to August 2008. The demographic profile, clinical data from for each individual in the cohort were statistically collated and analyzed. A P <0.05 was considered as statistically significant. Results: There were 72 participants (45 males and 27 females), aged 32.7 ± 9.8 years (range, 18 years to 72 years). Leukemic ophthalmopathy was present in 77.8% of subjects. The leading ophthalmic manifestations of leukemia were retinal vascular abnormalities in 50.0% of subjects, conjunctival pallor in 27.8% of subjects, sub-conjunctival hemorrhage in 19.4% of subjects, and retinal hemorrhage in 16.7% of subjects. Ocular co-morbidity was present in 47.2% of subjects. Vision loss occurred in 37.5% of subjects, of which 32.1% was leukemia related, and the remaining due to ocular co-morbidity. Leukemic ophthalmopathy was more prevalent in chronic leukemia (P <0.05), frequently affected the ocular posterior segment (P < 0.05), and often resulted from secondary hematologic complications (P <0.05). There was no gender difference in the prevalence of leukemia (P = 0.0822) or leukemic ophthalmopathy (P = 0.6624). Conclusion: The prevalence of leukemic ophthalmopathy in Enugu is high. It is often associated with significant ocular co-morbidity and vision loss. These have implications for clinicians involved in leukemia management. Early diagnosis and regular ophthalmic examinations are recommended to optimize treatment outcomes.

Eze, Boniface I.; Ibegbulam, Godswill O.; Ocheni, Sunday

2010-01-01

279

Associated autoantibodies in celiac disease  

Microsoft Academic Search

Celiac disease (CD) is a life-long inflammatory autoimmune condition of the gastrointestinal tract affecting genetically susceptible individuals. Several autoimmune disorders are more prevalent in patients and their close relatives and that risk is gluten exposure duration related. The most frequent reported CD associated conditions are type 1 diabetes mellitus and autoimmune thyroiditis. Associated autoimmune antibodies are frequent in CD and

Ron Shaoul; Aaron Lerner

2007-01-01

280

A girl with type 1 diabetes and a yellowish appearance  

Microsoft Academic Search

Type 1 diabetes mellitus in children has been associated with other autoimmune diseases, especially coeliac disease and autoimmune thyroiditis. This association may be the result of a common pathogenic background. We describe the case of a girl with type 1 diabetes mellitus who developed icterus due to autoimmune hepatitis, a disease rarely found in children. Thyroiditis-associated and diabetes-associated autoantibodies were

I C L Kremer Hovinga; E D Stam; M L Mearin; D Mul

2010-01-01

281

Management of Thyroid nodules in adult patients  

PubMed Central

Thyroid nodule is a common presentation and requires a structured diagnostic approach to ascertain the risk of malignancy and determine appropriate management. This review article highlights the key points in the history and examination which can help with risk stratification. It also discussed the application of fine needle aspiration cytology findings and the British Thyroid Association Guidelines in clinical practice.

2010-01-01

282

Pharmacophore identification of ascofuranone, potent inhibitor of cyanide-insensitive alternative oxidase of Trypanosoma brucei.  

PubMed

Trypanosoma brucei is a parasite that causes human African trypanosomiasis (HAT). The parasites depend on the cyanide-insensitive trypanosome alternative oxidase (TAO) for their vital aerobic respiration. Ascofuranone (AF), a potent and specific sub-nanomolar inhibitor of the TAO quinol oxidase, is a potential novel drug with selectivity for HAT, because mammalian hosts lack the enzyme. To elucidate not only the inhibition mechanism but also the inhibitor-enzyme interaction, AF derivatives were designed and synthesized, and the structure-activity relationship was evaluated. Here we identified the pharmacophore of AF that interacts with TAO. The detailed inhibitory profiles indicated that the 1-formyl and 6-hydroxyl groups, which might contribute to intramolecular hydrogen bonding and/or serve as hydrogen-bonding donors, were responsible for direct interaction with the enzyme. PMID:23180806

Saimoto, Hiroyuki; Kido, Yasutoshi; Haga, Yasushi; Sakamoto, Kimitoshi; Kita, Kiyoshi

2013-03-01

283

Pretibial myxedema as the initial manifestation of Graves' disease.  

PubMed

Pretibial myxedema (PM) is a localized thickening of the pretibial skin due to accumulation of acid mucopolysacharides (glycosaminoglycans). Its pathogenesis is still under investigation. Pretibial myxedema, exophthalmus and thyroid acropachy are the dassic extrathyroidal manifestations of Graves' disease. Almost invariably, PM follows the onset of ophthalmopathy, developing after the diagnosis and treatment of hyperthyroidism. Pretibial myxedema preceding Graves' ophthalmopathy is rare. We report the case of a 28-year-old Greek woman, who presented with multiple, asymptomatic nodules and plaques of the lower legs in the absence of other physical findings. Histopathologic examination revealed deposition of mucopolysacharides in the lower dermis. Laboratory investigation showed elevated serum T3 and T4 and depressed TSH levels. In our patient, pretibial myxedema was the earliest manifestation, leading to the diagnosis of Graves' disease. PMID:12224697

Georgala, S; Katoulis, A C; Georgala, C; Katoulis, E C; Hatziolou, E; Stavrianeas, N G

2002-07-01

284

[Perioperative treatment for the urgent orbital decompression surgery in a 30-weeks pregnant woman with Graves' orbitopathy].  

PubMed

Thyroid ophthalmopathy is a rare extra-thyroid complication usually associated with Graves' disease. This disease can occur in the euthyroid pregnant patient. Graves' orbitopathy is characterized by eyelid retraction, proptosis, extraocular muscle dysfunction, and periorbital edema. In some cases an emergency surgical repair may be required to avoid irreversible vision loss. We present the case of a 35-year-old woman in her 30th gestational week, who suffered from Graves' ophthalmopathy, severe exophthalmia, and visual acuity decrease. Following consultations among anesthesiologists, ophthalmologists, maxillofacial surgeons, endocrinologists, obstetricians and the patient, it was decided to perform a surgical orbital wall decompression. The anesthetic and perioperative implications associated with gestational age and the considerations for this surgical procedure, and how to avoid increasing intraocular pressure are discussed. PMID:23835254

Guerrero-Domínguez, R; López-Herrera-Rodríguez, D; Domínguez-Blanco, A; Medina-de Moya, I; Sánchez-Carrillo, F

2014-01-01

285

Reversal of optic neuropathy secondary to voluntary globe luxation.  

PubMed

Luxation of the globe is rare in the general population and may be spontaneous, voluntary, or traumatic. Spontaneous or voluntary globe luxation results from shallow orbit, floppy eyelids, lax orbital ligaments, backward displacement of orbital septum, or proptotic eyes due to orbital tumors or infiltrative processes, as in Grave's ophthalmopathy. The authors report a case with unilateral voluntary globe luxation presented with unilateral progressive visual loss. PMID:19157936

Yaman, Aylin; Ozturk, Taylan; Soylev, Meltem F

2009-04-01

286

Triad of exophthalmos, pretibial myxedema, and acropachy in a patient with Graves' disease.  

PubMed

Graves' disease is an autoimmune disorder of the thyroid gland with characteristic peripheral manifestations. The most common clinical findings include ophthalmopathy in 30% of patients, dermopathy (pretibial myxedema) in 4% of patients, and thyroid acropachy in 1% of patients. The triad of exophthalmos, pretibial myxedema, and acropachy occurs in less than 1% of patients. We present a case of Graves' disease with the clinical triad of eye disease, dermopathy, and acropachy. PMID:12789197

Anderson, Christina K; Miller, O Fred

2003-06-01

287

Significance of tissue specific and tissue non specific autoimmune reactions of Graves' disease.  

PubMed

The relationship between the many immunologic abnormalities demonstrated in the peripheral blood of patients with Graves' disease (GD) and the broad spectrum of clinical features with which patients may present has not yet been addressed in detail. In this review we examine the evidence to support the notion that GD could be considered a multi-system autoimmune disorder in which tissue damage is restricted to the thyroid gland, connective tissue of the skin and orbit, extra-ocular and other skeletal muscles and, possibly, the lacrimal glands. Apart from the well recognized reactions of autoantibodies and sensitized T lymphocytes with epitopes on the thyroid specific TSH receptor, thyroid peroxidase and thyroglobulin, in patients with hyperthyroidism, there is also good evidence for autoantibody and, to a lesser extent, T lymphocyte reactivity with several eye muscle, other skeletal muscle and connective tissue, antigens in patients with ophthalmopathy, systemic myopathy, dermopathy and acropachy. There is also some evidence for immunoreactivity against lacrimal gland antigens in patients with ophthalmopathy associated with other features of GD. There are, in addition, a variety of organ non-specific reactions in GD; antinuclear antibodies are detected in serum from about one-third of patients with hyperthyroidism and ophthalmopathy, while from 5% to 10% have antibodies reactive with several other ubiquitous tissue proteins. Cloned proteins which are autoantigenic in some patients with hyperthyroidism or Hashimoto's thyroiditis and ophthalmopathy include collagen XIII, nebulin, the calcium binding protein calmitine, and the Mac-II antigen. All antibodies reactive with eye muscle antigens, except the 64 kDa protein which is also expressed in the thyroid, cross react with the same, or a related, protein in other skeletal muscle. Future research should focus on the underlying mechanisms for this broad loss of tolerance to self antigens and the effect of environmental factors such as stress, radioiodine and viral infection of the thyroid gland and other target tissues, in precipitating disease. PMID:8828951

Kiljanski, J; Nebes, V; Wall, J R

1996-01-01

288

The effect of long-term somatostatin analogue treatment on free and total insulin-like growth factor (IGF) -I, -II and IGF binding protein -1, -2 and -3 serum levels in euthyroid patients with active thyroid eye disease  

Microsoft Academic Search

The aim of this study was to investigate the effect of long-term somatostatin analogue (SM-a) treat- ment on serum levels of free (F) and total (T) insulin-like growth factor (IGF)-I, -II and IGF binding protein (IGFBP) - 1, -2 and -3 in euthyroid patients with active thyroid ophthalmopathy. For this purpose, we measured the above-mentioned parameters in 21 patients (11M,

Gerasimos Krassas; Nikolaos Pontikides; Argyrios Dumas; Jan Frystyk; Jian-Wen Chen; Allan Flyvbjerg

289

Free and Total Insulin-Like Growth Factor (IGF)-I, -II, and IGF Binding Protein1, -2, and -3 Serum Levels in Patients with Active Thyroid Eye Disease  

Microsoft Academic Search

To determine whether serum levels of total (T) and free (F) IGF-I and -II and IGF binding protein (IGFBP),-1, -2, and -3 are normal in euthyroid patients with Graves' disease and ac- tive thyroid ophthalmopathy, we investigated the above- mentioned parameters in 21 patients (11 male, 10 female) aged 50.8 11.8 yr (range 35-70) and 19 healthy individuals matched for

G. E. Krassas; N. PONTIKIDES; T. KALTSAS; A. DUMAS; J. FRYSTYK; J. W. CHEN; A. FLYVBJERG

2003-01-01

290

Octreotide (Long-Acting Release Formulation) Treatment in Patients with Graves' Orbitopathy: Clinical Results of a Four-Month, Randomized, Placebo-Controlled, Double-Blind Study  

Microsoft Academic Search

Therearefeweffective,safemodalitiesforthemanagementof Graves' ophthalmopathy (GO), a cell-mediated immune co- morbidity of thyroid disease. Somatostatin analogs inhibit lymphocyte proliferation and activation, and accumulate in theorbitaltissueofpatientswithGO.Adouble-blind,placebo- controlled study of a long-acting somatostatin analog (16 wk of long-acting release formulation of octreotide (octreotide- LAR)) was conducted in 51 patients with mild active GO with the aim of preventing deterioration and precluding the need for

J. L. Wemeau; P. Caron; A. Beckers; V. Rohmer; J. Orgiazzi; F. Borson-Chazot; M. Nocaudie; P. Perimenis; S. Bisot-Locard; I. Bourdeix; S. Dejager

2004-01-01

291

Elephantiasic Pretibial Myxedema in a Patient With Graves Disease That Resolved After 131I Treatment.  

PubMed

Pretibial myxedema is a rare manifestation of Graves disease and is generally associated with ophthalmopathy. Steroids, immunoglobulin, or rituximab can have some therapeutic effect but not curative. Here we reported a 45-year-old man with history of hyperthyroidism for 20 years who developed severe bilateral pretibial myxedema. Three months after the treatment with I for his Graves disease, his pretibial myxedema was significantly improved. PMID:24830877

Yu, Haifang; Jiang, Xue; Pan, Mingzhi; Huang, Rui

2014-08-01

292

Combined transaortic transcatheter valve replacement and thoracic endografting.  

PubMed

Direct transaortic (TAo) approach for transcatheter aortic valve replacement (TAVR) in patients with symptomatic, severe aortic stenosis (AS) with prohibitive transfemoral access is being increasingly performed. Furthermore, concomitant catheter-based procedures such as percutaneous coronary intervention (PCI) are also being increasingly performed during TAVR. We report a single-stage, catheter-based treatment of both critical AS and descending thoracic aortic aneurysm (DTA) by performing TAVR with concomitant thoracic aortic endovascular repair (TEVAR) through direct TAo access via a minimally invasive partial sternotomy approach. To our knowledge, this is the first report of a "hybrid" TAVR+TEVAR. PMID:24484814

Komlo, Caroline M; Vallabhajosyula, Prashanth; Bavaria, Joseph E; Desai, Nimesh D; Anwaruddin, Saif; Giri, Jay S; Herrmann, Howard C; Szeto, Wilson Y

2014-02-01

293

Critical limb ischemia in a young man: saddle embolism or unusual presentation of thromboangiitis obliterans?  

PubMed

Thromboangiitis obliterans (TAO), also known as Buerger's disease, is a rare cause of peripheral arterial disease in western countries. Tobacco smoking is strongly correlated to the pathogenesis of this inflammatory vascular disease. We report the case of a 32-year-old tobacco and cannabis consumer presenting with right critical limb ischemia. Computerized tomography angiography revealed a bilateral tibioperoneal arterial occlusion and an aortoiliac saddle embolus. The patient was treated with intravenous heparin, transcatheter thrombolysis, and selective Fogarty embolectomy. Instrumental and laboratory examinations revealed that patient's most likely diagnosis was TAO. Arterial embolism is uncommon in Buerger's disease but should be always excluded in these patients. PMID:24367737

Bucci, Federico; Redler, Adriano; Fiengo, Leslie

2013-01-01

294

[Rituximab: a new therapeutic alternative in Grave's disease].  

PubMed

Graves' disease is the most frequent cause of hyperthyroidism, affecting mainly young aged women, with an etiology of autoimmune basis. One of its manifestations, Graves' ophthalmopathy whose pathophysiology is unknown, represents one of the greatest therapeutic challenges in these patients, because they require aggressive treatment with steroids and multiple subsequent reconstructive surgeries in certain cases. It also represents a high burden to the health system. Drugs targeting B cells have been very effective for many autoimmune diseases. Rituximab is a murine humanized monoclonal antibody against CD20 + cells currently being studied in various autoimmune diseases including Graves' disease. The objective of this paper is to expose possible mechanisms by which rituximab could act in both hyperthyroidism and ophthalmopathy of Graves' disease, as well as the experience with its use acquired so far. The employment of rituximab in recently diagnosed patients or with mild ophthalmopathy is questionable with the evidence available today however, we think that it may have a role in refractory cases or those who have a contraindication for steroid use. PMID:22468483

Tello-Winniczuk, Nina; Díaz-Jouanen, Efraín

2011-01-01

295

A polymorphism in the extracellular domain of the thyrotropin receptor is highly associated with autoimmune thyroid disease in females.  

PubMed

We and others have described previously a polymorphism at the first position of codon 52 (C52 --> A52) of the human thyrotropin receptor (hTSHr) gene. To determine its potential significance, we studied female (n = 100) and male (n = 25) patients with autoimmune thyroid disease (Graves' disease, n = 91; Hashimoto's thyroiditis, n = 34) and normal individuals [n = 121, female (n = 69), male (n = 52)]. Screening was performed using AciI restriction enzyme digestions of PCR-amplified genomic DNA. All codon 52 polymorphisms were verified by direct DNA sequencing. Data were analyzed using Chi-square or Fisher exact tests and p-values were corrected for multiple comparisons. Our studies demonstrated that this polymorphism is highly associated with autoimmune thyroid disease in the female population (corrected p = 0.008). We found no such association in the male population. Within females, there was a greater association between Graves' disease and the polymorphism (corrected p = 0.017) than between Hashimoto's thyroiditis and the polymorphism (corrected p = 0.090). The polymorphism was present in a higher proportion of Graves' disease patients with Graves' ophthalmopathy and pretibial dermopathy (40%) or Graves' ophthalmopathy, pretibial dermopathy, and acropachy (60%), than in patients with Graves' disease alone (15%), or Graves' disease and Graves' ophthalmopathy alone (17%). In conclusion, a polymorphism (C52 --> A52) of the hTSHr is associated with autoimmune thyroid disease in females. PMID:7544179

Cuddihy, R M; Dutton, C M; Bahn, R S

1995-04-01

296

Thyroid acropachy: report of 40 patients treated at a single institution in a 26-year period.  

PubMed

Thyroid acropachy is an extreme manifestation of autoimmune thyroid disease. It presents with digital clubbing, swelling of digits and toes, and periosteal reaction of extremity bones. It is almost always associated with ophthalmopathy and thyroid dermopathy. During a 26-yr period at our institution, of 178 patients with thyroid dermopathy, 40 had acropachy. Clubbing associated with thyroid dermopathy (pretibial myxedema) was seen in 35 patients. Clubbing usually was not a patient complaint and was noted only by clinical observers. Four of eight patients with hand and extremity radiographs had periosteal reaction. Seven had associated extremity and joint pain; this pain was absent at long-term follow-up. Half of the patients required systemic corticosteroid therapy, 53% required transantral or transfrontal orbital decompression for severe ophthalmopathy, and 18% had the elephantiasic form of dermopathy. Cigarette-smoking rates were 81% for women and 75% for men (mean, 28 pack-years). All 13 patients who had thyroid-stimulating Ig measurement had high titers. Long-term follow-up (median, 12.5 yr) revealed that acropachy was not a complaint in follow-up visits or questionnaires. The data suggest that thyroid acropachy is an indicator of severity of ophthalmopathy and dermopathy. It is a source of clinical concern only if dermopathy is persistent and severe. PMID:12466333

Fatourechi, Vahab; Ahmed, Debra D F; Schwartz, Kara M

2002-12-01

297

Dermopathy of Graves disease (pretibial myxedema). Review of 150 cases.  

PubMed

Pretibial myxedema is an uncommon manifestation of Graves disease, and little information is available regarding its natural course and its relation to other manifestations of Graves disease. We reviewed 150 consecutive cases with the diagnosis of pretibial myxedema over a 20-year period in a referral center. Only 1 patient in this group did not have ophthalmopathy, whereas 88% had significant proptosis and 30% required orbital decompression surgery. Dermopathy was a late manifestation of Graves disease, and its onset usually followed the diagnosis of hyperthyroidism and ophthalmopathy. In a few patients, dermopathy preceded diagnosis of hyperthyroidism or onset of ophthalmopathy. Fourteen patients were never clinically hyperthyroid; spontaneous hypothyroidism had developed in 11 in this group. All cases involved the lower extremities, with only 1 patient having combined upper and lower extremity involvement. The most common form of thyroid dermopathy was nonpitting edema, followed by nodular and plaque forms, which occurred with equal frequency. The polypoid form occurred in 1 patient and the elephantiasic form in another; 7.3% had thyroid acropachy. Follow-up was available for 120 patients (range, 3 mo to 19 yr; mean, 3.2 yr), and complete remission was observed in only 12 patients. Topically applied corticosteroid therapy was used in 76 patients, and in this group 38% had sustained long-term partial remission, as opposed to 18% in the group receiving no corticosteroid therapy. PMID:8309359

Fatourechi, V; Pajouhi, M; Fransway, A F

1994-01-01

298

Mouse Repository Strain Details  

Cancer.gov

Qingcong Lin, Alan B. Clark, Scott D. McCulloch, Tao Yuan, Roderick T. Bronson, Thomas A. Kunkel, and Raju Kucherlapati. Increased Susceptibility to UV-Induced Skin Carcinogenesis in Polymerase eta-deficient Mice. Cancer Res. 66, 87-94, 2006.

299

Relapse Prevention Needs More Emphasis on Interpersonal Factors  

ERIC Educational Resources Information Center

This article presents comments on "Relapse Prevention for Alcohol and Drug Problems: That Was Zen, This Is Tao," by Katie Witkiewitz and G.A. Marlatt. Stanton notes that the recent reconceptualization of relapse prevention by Witkiewitz and Marlatt enhances the model by "synthesizing recent empirical findings into a unified theory", but it does…

Stanton, Mark

2005-01-01

300

Emphasis on Interpersonal Factors in a Dynamic Model of Relapse  

ERIC Educational Resources Information Center

This article presents comments on "Relapse Prevention Needs More Emphasis on Interpersonal Factors" by Stanton which is a comment on the original article "Relapse Prevention for Alcohol and Drug Problems: That Was Zen, This Is Tao" by Katie Witkiewitz and G. Alan Marlatt. In the current comment the authors of the original article respond to…

Witkiewitz, Katie; Marlatt, G. Alan

2005-01-01

301

78 FR 18783 - Establishment of the R[iacute]o Grande del Norte National Monument  

Federal Register 2010, 2011, 2012, 2013

...expanse of the Taos Plateau. Volcanic cones, including the Cerro de la Olla, Cerro...surrounding plateau. Canyons, volcanic cones, wild rivers, and native grasslands harbor...across the forested slopes of the volcanic cones bear ample testimony to the human use...

2013-03-28

302

Grover  

USGS Multimedia Gallery

Grover was built in just four months in 1971 by the USGS Astrogeology Research Program (called the Branch of Astrogeology at the time) and used to training Apollo 15-17 astronauts at the Cinder Lakes training ground near Flagstaff, in California's Mojave Desert, and in the Rio Grande gorge near Taos...

2009-07-22

303

The Role of Discursive Resources in Science Talk  

ERIC Educational Resources Information Center

Tao, Oliver, and Venville's paper addresses a debate between two hypotheses of children's development of conceptual understandings of the Earth. The authors aim to investigate whether culture influences students' conceptions of the Earth. However, one questionable assumption shared among conception and conceptual change studies is that researchers…

Hsu, Pei-Ling

2013-01-01

304

Prototype KPIs for rural infrastructure development : The practice of sub-district local governments  

Microsoft Academic Search

Purpose – It is difficult to manage and measure the effectiveness of infrastructure development efforts of the sub-district local governments called Tambon Administrative Organizations (TAOs), the lowest level of local governments in Thailand. This paper aims to develop and demonstrate the applicability of key performance indicators (KPIs) based on the integration of balanced scorecard (BSC) and value chain approaches. Design\\/methodology\\/approach

Suchanya Posayanant; Chotchai Chareonngam

2010-01-01

305

A comparison of classification techniques to support land cover and land use analysis in tropical coastal zones  

Microsoft Academic Search

This study assesses the performance of the support vector machine image classification technique in the context of a tropical coastal zone exhibiting low to medium scale development. The overall and individual classification results of this approach were compared to the maximum likelihood classifier and the artificial neural network techniques. A 15-m spatial resolution ASTER image of Koh Tao in Thailand was

Brian W. Szuster; Qi Chen; Michael Borger

2011-01-01

306

In Vitro Endotoxin Exposure Induces Contractile Dysfunction in Adult Rat Cardiac Myocytes.  

National Technical Information Service (NTIS)

Tao, Shiying, and Thomas M. McKenna. In vitro endo- toxin exposure induces contractile dysfunction in adult rat cardiac myocytes. Am. J. Physiol. 267 (Heart Circ. Physiol. 36): 111745-111752, 1994.-In vivo endotoxin treatment causes a nitric oxide-mediate...

S. Tao T. M. McKenna

1994-01-01

307

Tropical Atmosphere Ocean Project: El Nino and La Nina 3-D Visualizations  

NSDL National Science Digital Library

Users can view a selection of animations of ocean surface temperature and dynamic height derived from data from the TAO/TRITON buoy array moored in the Pacific Ocean. The animations show temperature and surface topography variations consistent with the development of El Nino and La Nina events.

308

Radiation measurements by brookhaven national laboratory during the woods hole oceanographic institution intercomparison study, may-june 2000.  

National Technical Information Service (NTIS)

The WHOI buoy radiometer intercomparison took place during May and June, 2000 at the WHOI facility. The WHOI IMET, JAMSTEC Triton, and NOAA TAO buoy systems were operated from a beach site and the Brookhaven National Laboratory set up two Portable Radiati...

R. M. Reynolds M. J. Bartholomew M. A. Miller S. Smith R. Edwards

2000-01-01

309

An Inventory of Natural, Human, and Social Overhead Capital Resources in North-Central New Mexico.  

ERIC Educational Resources Information Center

Concerned with the north-central area of New Mexico (Rio Arriba, Taos, Colfax, Mora, Santa Fe, and San Miguel counties), this inventory describes the situation and delineation of the region, the natural resources (physical characteristics, land, land-ownership patterns, land-use patterns, land-title problems, water resources, and minerals); human…

Carruthers, Garrey; Eastman, Clyde

310

Genotypic variations in cadmium levels of rice grain  

Microsoft Academic Search

To identify rice grain genotypes with a lower cadmium content, 49 cultivars of rice were tested under upland conditions, using two types of soils contaminated with cadmium (A: alluvial and B: volcanic ash soil) in 1999 and 2000. Results of ranking of grain cadmium concentrations were similar between these 2 years. NIPPONBARE, KOSHIHIKARI, and HU-LO-TAO belonged to the rice grain

T. Arao; N. Ae

2003-01-01

311

Online-Trade's Analysis of Decentralized Network Based on Cybermediary: A Case Study of Taobao.com  

Microsoft Academic Search

The role and influence that cybermediaries play in transforming various market places is an important area for research. This paper presents an analysis of transaction cost during three important stages associated with online trading, and the benefits of a cybermediary (an intermediary) in open decentralized market models compared to direct exchanges. The TaoBao.com's practice is used to demonstrate that decentralized

Wei Chu

2007-01-01

312

Photoplethysmographic Assessment of Pulse Wave Reflection Blunted Response to Endothelium-Dependent Beta2Adrenergic Vasodilation in Type II Diabetes Mellitus  

Microsoft Academic Search

METHODS The DVP was recorded by photoplethysmography. Albuterol (salbutamol) and glyceryl trinitrate (GTN) were administered locally by brachial artery infusion or systemically. Aortic pulse wave transit time from the root of the subclavian artery to aortic bifurcation (TAo) was measured by simultaneous Doppler velocimetry. RESULTS Brachial artery infusion of drugs producing a greater than threefold increase in forearm blood flow

Philip J. Chowienczyk; Ronan P. Kelly; Helen MacCallum; Sandrine C. Millasseau; Tomas L. G. Andersson; Raymond G. Gosling; James M. Ritter; Erik Eo Anggard

313

Killing Mosquitoes and Keeping Practice: Teacher Education as Sustaining Paradox  

ERIC Educational Resources Information Center

The moral and ethical charge of teaching and teacher education includes sustaining equanimity and paradox, and maintaining poise amongst contradicting policies and interests. This paper draws upon the wisdom of the Tao Te Ching to address some paradoxes in education and teacher preparation. Specifically, the article looks at four chapters of the…

Keiser, David Lee

2013-01-01

314

Observations and Calculations of Light Scattering from Clusters of Spheres.  

National Technical Information Service (NTIS)

Two-dimensional angular optical scattering (TAOS) from clusters of polystyrene latex spheres is measured in the near-forward and near-backward directions. In both cases, the scattering pattern contains a rich and complicated structure due to the interacti...

S. Holler J. Auger B. Stout Y. Fan J. R. Bottiger

2000-01-01

315

The Pueblo Indians of New Mexico: An Analysis of the Educational System.  

ERIC Educational Resources Information Center

Educational systems (both tribal and formal) of the Pueblo Indians, including Taos, San Juan, Tesuque, Zia, Zuni, and the Bernalillo District in New Mexico, were analyzed. The analysis included discerning whether or not (1) the Pueblos' traditional culture and heritage is being taught and to what extent and (2) bilingual and bicultural studies…

Cibrario, Dominic J.

316

Trial prospector: An automated clinical trials eligibility matching program. | accrualnet.cancer.gov  

Cancer.gov

Parchman AJ,Zhang G-Q,Mergler P,Barnholtz-Sloan J,Lanese R,Miller DM,Opper C,Sahoo S,Tao S,Teagno J,Warfe J,Meropol NJ. University Hospitals Seidman Cancer Center, Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH. ASCO 2013 Annual Meeting. 2013 May 31. 2013 Jun 04.

317

Different Perspectives of Cultural Mediation: Implications for the Research Design on Studies Examining Its Effect on Students' Cognition  

ERIC Educational Resources Information Center

In this forum, I extend Tao, Oliver, and Venville's paper "Chinese and Australian children's understanding of the earth: a cross cultural study of conceptual development" to discuss the different views on culture and cultural mediation. I tease out nuances in the viewpoints to suggest three ways to theoretically frame studies examining cultural…

Teo, Tang Wee

2013-01-01

318

THERMAL CAMERA IMAGING OF ROCK PILES AT THE QUESTA MOLYBDENUM MINE, QUESTA, NEW MEXICO1  

Microsoft Academic Search

Between 1969 and 1981 open pit methods were used to recover the molybdenum ore producing some 317.5 million metric tons of mined rock from the Questa molybdenum mine, which went into nine rock piles. The mine is located in the Sangre de Cristo Mountains of Taos County in northern New Mexico. As part of a multi-disciplinary study to determine the

Heather R. Shannon; John M. Sigda; Remke L. Van Dam; Jan M. H. Hendrickx; Virginia T. McLemore

319

We Shared the Same Chapter: Collaboration, Learning, and Transformation from the 2008 Subsistence, the Environment, and Community Well-Being Native Youth Exchange in Old Harbor, Alaska Project  

ERIC Educational Resources Information Center

On a small island belonging to the Alutiiq people of Old Harbor, 11 people sat around a campfire. Two community leaders, a nonprofit organizer, an academic scholar, a native filmmaker, and six young people from the Indian reservation of Taos Pueblo in New Mexico gathered after a day of interacting with Old Harbor residents--fishing, hunting and…

Richmond, Laurie; Di Piero, Daniela; Espinoza, Flowers; Simeonoff, Teacon; Faraday, Margaret

2010-01-01

320

The Plumed Serpent and the Red Atlantis.  

ERIC Educational Resources Information Center

Examines work of author D.H. Lawrence and John Collier, later Bureau of Indian Affairs Commissioner, during 1920s when they stayed as Mabel Dodge Luhan's guests in Taos, New Mexico. Examines their perceptions of Pueblo Indian culture, federal-Indian relationship, and Indian influences on Lawrence's and Collier's work. (TES)

Willard, William

1988-01-01

321

Influence of reactive gas pressure on the properties of thin film Ta2O5  

Microsoft Academic Search

An intensive investigation concerning the specific properties of dc reactively sputtered thin film TaO5 and the influence of the fabrication condition was carried out. The examined properties involved electronic properties (dielectric constant, dielectric loss, leakage current and breakdown voltage), an optical property (refractive index) and structural properties (crystalline structure and surface texture). Both the electronic and optical properties were found

Utis Teravaninthorn; Yuji Miyahara; Toyosaka Moriizumi

1987-01-01

322

Self-Rectifying Effect in Resistive Switching Memory Using Amorphous InGaZnO  

NASA Astrophysics Data System (ADS)

Resistance random access memory (ReRAM) has received attention as next-generation memory because of its excellent operating properties and high density integration capability as a crossbar array. However, the application of the existing ReRAM as a crossbar array may lead to crosstalk between adjacent cells due to its symmetric I- V characteristics. In this study, the self-rectifying effect of contact between amorphous In-Ga-Zn-O (a-IGZO) and TaO x was examined in a Pt/a-IGZO/TaO x /Al2O3/W structure. The experimental results show not only self-rectifying behavior but also forming-free characteristics. During the deposition of a-IGZO on the TaO x , an oxygen-rich TaO x interfacial layer was formed. The rectifying effect was observed regardless of the interface formation and is believed to be associated with Schottky contact formation between a-IGZO and TaO x . The current level remained unchanged despite repeated DC sweep cycles. The low resistance state/high resistance state ratio was about 101 at a read voltage of -0.5 V, and the rectifying ratio was about 103 at ±2 V.

Lee, Jin-Woo; Kwon, Hyeon-Min; Kim, Myeong-Ho; Lee, Seung-Ryul; Kim, Young-Bae; Choi, Duck-Kyun

2014-05-01

323

Curing the Medical Manpower Shortage  

ERIC Educational Resources Information Center

The OEO-funded Sangre de Cristo Comprehensive Health System in Costilla and Conejos Counties, Colorado, and northern Taos County, New Mexico, utilizes medical practitioners who are certified to practice a variety of medical techniques under the supervision of licensed physicians. (JM)

Murphy, Betty

1973-01-01

324

Direct determination of gold in rock samples using collision cell quadrupole ICP-MS.  

PubMed

This study investigated the determination of Au in rock samples using collision cell quadrupole inductively coupled plasma mass spectrometry (ICP-MS). It is essential to remove various interferents using a collision cell because polyatomic ions such as (181)Ta(16)O(+) and (180)Hf(16)O(1)H(+) can interfere with the direct determination of monoisotopic (197)Au when using ICP-MS. The addition of oxygen as a reaction gas removed isobaric interferents by transforming TaO(+) and HfOH(+) to TaO(2)(+), TaO(3)(+), and HfO(2)H(+), HfO(3)H(+), respectively, in the cell without significant Au(+) loss. The ion kinetic energy effect (IKEE) due to the potential difference between the plasma and the hexapole affected the reactions in the cell. Au and interfering ions were very sensitive to cell bias voltage (Vc) at constant plasma potential (Vp) and quadrupole bias voltage (Vq). Under the condition of hot plasma, the transmission of ions was promoted, and the maximum Au signal intensity was 50% greater than under normal conditions. At Vc > 7 V, TaO(+) ions were removed to background level. Optimized conditions for real sample analysis were obtained by introducing He as an additional collision gas in hot plasma. TaO(+) ions were removed to background level at He flow rates above 0.6 mL min(-1), and the Au signal remained high. The detection limit (three times the standard deviation of the blank) of this method was 3.06 pg g(-1). The results for reference materials (STM-1 and DGPM-1) and spiked samples showed good agreement between specified and measured concentrations. PMID:22045542

Yim, Seong A; Choi, Man Sik; Chae, Jung Sun

2012-01-01

325

Thymic hyperplasia presenting as anterior mediastinal mass in 2 patients with Graves disease.  

PubMed

Graves disease is an autoimmune thyroid condition characterized by the production of autoantibodies against the thyrotropin receptor. The autoantibodies mimic the effect of the hormone on thyroid cells, which stimulates autonomous production of thyroxine and triiodothyronine. It has been hypothesized that cross-reactivity of autoantibodies may result in Graves ophthalmopathy and dermopathy. A seldom-recognized feature of Graves disease is thymic hyperplasia. We report 2 patients with Graves disease and incidentally discovered anterior mediastinal masses presumed to be thymic hyperplasia. In both cases, these masses regressed spontaneously after treatment of hyperthyroidism. PMID:12005000

Budavari, Adriane I; Whitaker, Michael D; Helmers, Richard A

2002-05-01

326

Role of lone-pair electrons in Sb-doped amorphous InGaZnO4: Suppression of the hole-induced lattice instability  

NASA Astrophysics Data System (ADS)

Transparent amorphous oxide semiconductors (TAOS's) are of practical importance for applications including oxide electronics and displays. Here we show the lone-pair s-electrons incorporated by for example Sb-doping can suppress the hole-induced lattice instability, which has been a major obstacle to commercial application of the TAOS-based thin film transistors. The Sb(III)-O sp?* hybridization in the top-most valence states makes the lone-pair s-electrons to capture the excited holes, the Sb(V)O6 octahedral bonding configuration by which formed is easily dissociated into the stable lone-pair Sb(III) state by recapturing conduction electrons.

Nahm, Ho-Hyun; Kim, Yong-Sung

2013-04-01

327

Photocatalytic activity of R3MO7 and R2Ti2O7 (R=Y, Gd, La; M=Nb, Ta) for water splitting into H2 and O2.  

PubMed

The photocatalytic activities of R3MO7 and R2Ti2O7 (R=Y, Gd, La; M=Nb, Ta) strongly depended on the crystal structure. Overall, photocatalytic water splitting into H2 and O2 proceeded over La3TaO7 and La3NbO7, which have an orthorhombic weberite structure, Y2Ti2O7 and Gd2Ti2O7, which have a cubic pyrochlore structure, and La2Ti2O7, which has a monoclinic perovskite structure. All of these materials are composed of a network of corner-shared octahedral units of metal cations (TaO6, NbO6, or TiO6); materials without such a network were inactive. The octahedral network certainly increased the mobility of electrons and holes, thereby enhancing photocatalytic activity. PMID:16471807

Abe, Ryu; Higashi, Masanobu; Sayama, Kazuhiro; Abe, Yoshimoto; Sugihara, Hideki

2006-02-01

328

The impacts of ozonation on oil sands process-affected water biodegradability and biofilm formation characteristics in bioreactors.  

PubMed

To examine the effects of the ozonation process (as an oxidation treatment for water and wastewater treatment applications) on microbial biofilm formation and biodegradability of organic compounds present in oil sands process-affected water (OSPW), biofilm reactors were operated continuously for 6weeks. Two types of biofilm substrate materials: polyethylene (PE) and polyvinylchloride (PVC), and two types of OSPW-fresh and ozonated OSPWs-were tested. Endogenous microorganisms, in OSPW, quickly formed biofilms in the reactors. Without ozonation, the bioreactor (using endogenous microorganisms) removed 13.8% of the total acid-extractable organics (TAO) and 18.5% of the parent naphthenic acids (NAs) from fresh OSPW. The combined ozonation and biodegradation process removed 87.2% of the OSPW TAO and over 99% of the OSPW parent NAs. Further UPLC/HRMS analysis showed that NA biodegradability decreased as the NA cyclization number increased. Microbial biofilm formation was found to depend on the biofilm substrate type. PMID:23313671

Hwang, Geelsu; Dong, Tao; Islam, Md Sahinoor; Sheng, Zhiya; Pérez-Estrada, Leónidas A; Liu, Yang; Gamal El-Din, Mohamed

2013-02-01

329

CORBA Evaluations for the BABAR Online System  

SciTech Connect

The Common Object Request Broker Architecture (CORBA) is a software system to deal with distributed object computing. The release of CORBA version 2, and real implementations from numerous vendors (both freeware and payware) have made its use very attractive for interprocess and interprocessor communication within an object-oriented software system. A number of object request brokers (ORBs) were evaluated for possible use within the BABAR Online system. Given an expectation for a reasonable level of performance within the Online system, it was essential to characterize the behavior and test the response of these products prior to their adoption. This paper summarizes the results of a systematic performance study of six ORB products. The products tested include: Visibroker, Orbix, DAIS, Omnibroker, OmniORB2, and TAO. Performance results of ORB products, including a test of TCP/IP sockets, are compared. These tests resulted in the adoption of the TAO ORB for use within the BABAR Online system.

Glanzman, Thomas

1998-11-03

330

Multiclass posterior probability support vector machines.  

PubMed

Tao, et al have recently proposed the posterior probability support vector machine (PPSVM) which uses soft labels derived from estimated posterior probabilities to be more robust to noise and outliers. Tao, et al's model uses a window-based density estimator to calculate the posterior probabilities and is a binary classifier. We propose a neighbor-based density estimator and also extend the model to the multiclass case. Our bias-variance analysis shows that the decrease in error by PPSVM is due to a decrease in bias. On 20 benchmark data sets, we observe that PPSVM obtains accuracy results that are higher or comparable to those of canonical SVM using significantly fewer support vectors. PMID:18269944

Gonen, Mehmet; Tanugur, Ay?e Gönül; Alpaydin, Ethem

2008-01-01

331

Pacific Marine Environmental Laboratory On-Line Data  

NSDL National Science Digital Library

This site provides access to a variety of oceanographic and atmospheric data products. Some of the products available include Ocean Buoy data, tsunami data, 1997-98 El Nino sea level for the US West Coast, Alaska, and Hawaii, real-time images and data from research ships, climate databases via the FERRET program, the Atmospheric Chemistry Data Server, seafloor data from the coaxial segment of the Juan de Fuca Ridge, data on exploration of hydrothermal vents, Florida current transport data, EPIC observational data, Pacific Ocean hydrography from WOCE P15S Cruise cross sections, Ka'imimoana Shipboard Acoustic Doppler Current Profile (ADCP) Data, Atmospheric Chemistry Trace Gas Program data, Historical TAO CTD data, near real-time TAO CTD data, and access to other distributed NOAA data and information. This site also has animations and virtual reality displays of tsunamis, El Nino and La Nina, fisheries oceanography, and Convection and Circulation at Ocean Ridge Crests.

332

Compositional investigation of liquid crystal alignment on tantalum oxide via ion beam irradiation  

SciTech Connect

The homogeneously aligned liquid crystal display on Ta{sub 2}O{sub 5} via ion beam (IB) irradiation was first embodied with controllability of pretilt angle depending on incident angle of the IB. As a result of x-ray photoelectron spectroscopic analysis, the intensity of Ta-O and O-Ta bondings as a function of incident angle behaved reversely with the pretilt angle and the lowest amplitude was observed at 45 deg. It revealed that the creation of pretilt angle was attributed to the irradiation of the IB by breaking Ta-O and O-Ta bonding so orientational order was generated by directional IB. Comparable electro-optical characteristics to rubbed polyimide were also achieved.

Kim, Jong-Yeon; Oh, Byeong-Yun; Kim, Byoung-Yong; Kim, Young-Hwan; Han, Jin-Woo; Han, Jeong-Min; Seo, Dae-Shik [Department of Electrical and Electronic Engineering, College of Engineering, Yonsei University, 134 Shinchon-dong, Seodaemoon-ku, Seoul 120-749 (Korea, Republic of)

2008-01-28

333

Searching for Hidden, Painful Osteochondral Lesions of the Ankle in Patients with Chronic Lower Limb Pain - Two Case Reports -  

PubMed Central

It is easy to overlook osteochondral lesions (OCLs) of the ankle in patients with chronic lower limb pain, such as complex regional pain syndrome (CRPS) or thromboangiitis obliterans (TAO, Buerger's disease). A 57-year-old woman diagnosed with type 1 CRPS, and a 58-year-old man, diagnosed with TAO, complained of tactile and cold allodynia in their lower legs. After neurolytic lumbar sympathethic ganglion block and titration of medications for neuropathic pain, each subject could walk without the aid of crutches. However, they both complained of constant pain on the left ankle during walking. Focal tenderness was noted; subsequent imaging studies revealed OCLs of her talus and his distal tibia, respectively. Immediately after percutaneous osteoplasties, the patients could walk without ankle pain. It is important to consider the presence of a hidden OCL in chronic pain patients that develop weight-bearing pain and complain of localized tenderness on the ankle.

Ri, Hyun Su; Lee, Dong Heon

2013-01-01

334

Religion and Social Work: An Analysis of Faith Traditions, Themes, and Global North\\/South Authorship  

Microsoft Academic Search

This study uses the search terms “Baha'i,” “Buddh*,” “Confucian*,” “Christian,*” “Druze,” “Hindu*,” “Islam*,” “Muslim*,” “Jew*,” “Juda*,” “Sikh*,” “Tao*,” “Traditional Spirit*,” “Wicca,” and “Zoroastrian*” as keyword descriptors in abstracts of two databases—Social Work Abstracts and Social Service Abstracts—from the mid?1960s to 2007. It finds Judaism, Christianity, and Islam to have the most attention; nearly a third of all articles appear in

John R. Graham; Micheal Shier

2009-01-01

335

Optical scattering patterns from single urban aerosol particles at Adelphi, Maryland, USA: A classification relating to particle morphologies  

Microsoft Academic Search

Angularly resolved elastic light scattering patterns from individual atmospheric aerosol particles (diameter 0.5–12 micrometers) sampled during fall (October 2004) at an urban site in the Baltimore-Washington metroplex are reported. These two-dimensional angular optical scattering (TAOS) patterns were collected for polar scattering angles $\\\\theta$ varying from approximately 75° to 135° and azimuthal angles $\\\\phi$ varying from 0° to 360°. Approximately 6000

K. B. Aptowicz; R. G. Pinnick; S. C. Hill; Y. L. Pan; R. K. Chang

2006-01-01

336

Optical scattering patterns from single urban aerosol particles at Adelphi, Maryland, USA: A classification relating to particle morphologies  

Microsoft Academic Search

(1) Angularly resolved elastic light scattering patterns from individual atmospheric aerosol particles (diameter 0.5-12 micrometers) sampled during fall (October 2004) at an urban site in the Baltimore-Washington metroplex are reported. These two-dimensional angular optical scattering (TAOS) patterns were collected for polar scattering angles q varying from approximately 75? to 135? and azimuthal angles f varying from 0? to 360? .

K. B. Aptowicz; R. G. Pinnick; S. C. Hill; Y. L. Pan; R. K. Chang

2006-01-01

337

Convergence order of wavelet thresholding estimator for differential operators on Besov spaces  

Microsoft Academic Search

The almost everywhere convergence of wavelet series is important in wavelet analysis [S. Kelly, M.A. Kon, L.A. Raphael, Local convergence for wavelet expansions, J. Funct. Anal. 126 (1994) 102–138]. Since the thresholding method plays fundamental roles in data compression, signal processing and other areas, the pointwise convergence of resulting wavelet series was investigated by T. Tao and B. Vidakovic in

Youming Liu; Huiying Wang

338

Internet Therapy Versus Internet Self-Help Versus No Treatment for Problematic Alcohol Use: A Randomized Controlled Trial  

Microsoft Academic Search

Objective: Problematic alcohol use is the third leading contributor to the global burden of disease, partly because the majority of problem drinkers are not receiving treatment. Internet-based alcohol interventions attract an otherwise untreated population, but their effectiveness has not yet been established. The current study examined the effectiveness of Internet-based therapy (therapy alcohol online; TAO) and Internet-based self-help (self-help alcohol

Matthijs Blankers; Maarten W. J. Koeter; Gerard M. Schippers

2011-01-01

339

Trace Perchlorate in Background Ground Water and Local Precipitation, Northern Rio Grande Basin, New Mexico  

Microsoft Academic Search

Perchlorate occurs at detectable concentrations of 0.07 to 0.45 parts per billion (ppb) in ground water of background quality within the northern Rio Grande basin, New Mexico. Ground-water samples were collected from 47 wells and springs near Los Alamos, Santa Fe, and Taos, New Mexico. Analytical methods consisted of liquid and ion chromatography-mass spectrometry mass spectrometry (LC\\/MS\\/MS and IC\\/MS\\/MS). An

M. Dale; P. Longmire; K. P. Granzow; D. Englert; S. Yanicak; T. Larson; M. Rearick; J. Heikoop; G. Perkins

2007-01-01

340

Use of Ocean Remote Sensing Data to Enhance Predictions with a Coupled General Circulation Model  

NASA Technical Reports Server (NTRS)

Surface height, sea surface temperature and surface wind observations from satellites have given a detailed time sequence of the initiation and evolution of the 1997/98 El Nino. The data have beet complementary to the subsurface TAO moored data in their spatial resolution and extent. The impact of satellite observations on seasonal prediction in the tropical Pacific using a coupled ocean-atmosphere general circulation model will be presented.

Rienecker, Michele M.

1999-01-01

341

Regional discrimination studies: Phase III. Scientific report No. 3  

SciTech Connect

This report consists of three parts. Part 1, `Construction of Regional Ground Truth Data Bases Using Seismic And Infrasound Data` is by Gordon Sorrells, Eugene Herrin, and Jessie Bonner with contributions from Jack Swanson, Sarah Deering and Angela Maddox. Part 2, `Seismic And Infrasound Data Observations At TXAR` is by Jessie Bonner, Sarah Deering, Tao Liu, Jack Swanson and Ileana Tibuleac. Part 3, consists of the Acknowledgments called for by the contract.

Bonner, J.; Herrin, E.; Sorrells, G.G.

1997-03-01

342

CosmicAI: generating sky backgrounds through content-based search and flexible composition  

Microsoft Academic Search

In film and game production, sky images are frequently changed to fit a given situation. SkyFinder [Tao et al. 2009] and A System for Editing Sky Images Using an Image Database (Ono2011 for short hereafter) [Ono et al. 2011] allow the users to generate sky images efficiently without three dimensional computer graphics software such as Vue and Terragen. SkyFinder users

Takanobu Mitani; Issei Fujishiro

2012-01-01

343

Mechanism-based inhibition of CYP3A4 and CYP3A5 by seven inhibitors  

Microsoft Academic Search

We evaluated the potential for inhibition of CYP3A4 and CYP3A5 using seven mechanism-based inhibitors: troleandomycin (TAO), erythromycin (ERY), 6`, 7`-dihydroxybergamottin (DHB), diltiazem (DIL), verapamil (VER), ethynyl estradiol (EE) and ritonavir. These inhibitors were preincubated with NADPH and recombinant enzymes (CYP3A4 and CYP3A5) for 20 minutes. Enzyme activity was determined by 1-hydroxy triazolam (1-OH TRZ) formation from triazolam (250?M). Using recombinant

K. C. Patki; L. L. von Moltke; D. J. Greenblatt

2004-01-01

344

Environmental Barrier Coatings for the Energy Efficient Heat Engines Program  

Microsoft Academic Search

This program aimed to develop a fundamental understanding of the microstructural, mechanical, and chemical properties of TaO-based coatings for SiN (AS800) substrates and optimize such coatings for environmental barriers. The program consisted of three tasks: processing of TaO coatings, phase and microstructural development, and life-limiting phenomena. Northwestern University formed a cross-functional team with Lehigh University, Honeywell Inc., and Oak Ridge

Katherine Faber

2004-01-01

345

Comparative Study of Electrocoagulation and Electrooxidation Processes for the Degradation of Ellagic Acid From Aqueous Solution  

Microsoft Academic Search

A comparative study of electrocoagulation and electrooxidation processes for the degradation of ellagic acid from aqueous solution was carried out. For the electrocoagulation process, metallic iron was used as electrodes whereas graphite and RuO2\\/IrO2\\/TaO2 coated titanium electrodes were used for the electrooxidation processes. The effect of the process variables such as initial pH, concentration of the supporting electrolyte, applied current

M. Muthukumar; M. Govindaraj; A. Muthusamy; G. Bhaskar Raju

2010-01-01

346

Topological insulators on a Mobius Strip  

NASA Astrophysics Data System (ADS)

We study the two dimensional Chern insulator and spin Hall insulator on a non-orientable Riemann surface, the Mobius strip, where the usual bandstructure topological invariant is not defined. We show that while the flow pattern of edge currents can detect the twist of the Mobius strip in the case of Chern insulator, it can not do so in spin Hall insulator [1]. [4pt] [1] Lang-Tao Huang and Dung-Hai Lee, Phys. Rev. B 84, 193106 (2011)

Huang, Lang-Tao; Lee, Dung-Hai

2012-02-01

347

Nonlinear dielectric susceptibility in the potassium tantalate with lithium  

Microsoft Academic Search

The measurements of temperature (10 K < T < 300 K) and dc electric field dependencies of nonlinear dielectric susceptibility were performed in K1-x Lix TaO3 with × = 0.01, 0.025 and 0.035 at 0 < E < 12 kV\\/cm and frequency ? = 100 kHz. Analysis of obtained data has shown the existence of mixed phase with coexistence of

S. N. Nokhrin; I. P. Bykov; M. D. Glinchuk; L. Jastrabik; M. Hrabovsky

1999-01-01

348

Role of biotransformation in 3-(3,5-dichlorophenyl)-2,4-thiazolidinedione-induced hepatotoxicity in Fischer 344 rats.  

PubMed

Cytochrome P450 (CYP)-mediated metabolism in the thiazolidinedione (TZD) ring may contribute to the hepatotoxicity of the insulin-sensitizing agents such as troglitazone. We were interested in determining if biotransformation could also be a factor in the liver damage associated with another TZD ring containing compound, 3-(3,5-dichlorophenyl)-2,4-thiazolidinedione (DCPT). Therefore, hepatotoxic doses of DCPT (0.6 or 1.0 mmol/kg, i.p.) were administered to male Fischer 344 rats after pretreatment with vehicle, 1-aminobenzotriazole (ABT, non-selective CYP inhibitor) and troleandomycin (TAO, CYP3A inhibitor). Alternatively, rats were pretreated with vehicle or the CYP3A inducer dexamethasone (DEX) prior to a non-toxic DCPT dose (0.2 mmol/kg, i.p.). Vehicle-, ABT-, TAO- and DEX-only control groups were also run. Toxicity was assessed 24 h after DCPT administration. Both hepatotoxic doses of DCPT induced elevations in serum alanine aminotransferase (ALT) levels that were attenuated by ABT or TAO pretreatment. Liver sections from rats that received vehicle+DCPT revealed areas of gross necrosis and neutrophil invasion, whereas sections from ABT+DCPT and TAO+DCPT rats showed minor changes compared to controls. DEX pretreatment potentiated ALT levels associated with the non-toxic DCPT dose. Furthermore, DEX+DCPT rat liver sections exhibited hepatic injury when compared against rats that received vehicle+DCPT. Blood urea nitrogen levels, urinalysis and kidney morphology were not markedly altered by any combination of pretreatments or treatments. Enzyme activity and Western blotting experiments with rat liver microsomes confirmed the effects of the various pretreatments. Our results suggest that hepatic CYP3A isozymes may be involved in DCPT-induced liver damage in male rats. We believe this is the first report demonstrating that modulation of the biotransformation of a TZD ring-containing compound can alter hepatotoxicity in a common animal model. PMID:18621092

Crincoli, Christine M; Patel, Niti N; Tchao, Ruy; Harvison, Peter J

2008-09-01

349

Self-compliance RRAM characteristics using a novel W/TaO x /TiN structure  

PubMed Central

Self-compliance resistive random access memory (RRAM) characteristics using a W/TaO x /TiN structure are reported for the first time. A high-resolution transmission electron microscope (HRTEM) image shows an amorphous TaO x layer with a thickness of 7 nm. A thin layer of TiO x N y with a thickness of 3 nm is formed at the TaO x /TiN interface, owing to the oxygen accumulation nature of Ti. This memory device shows 100 consecutive switching cycles with excellent uniformity, 100 randomly picked device-to-device good uniformity, and program/erase endurance of >103 cycles. It is observed that the 0.6-?m devices show better switching uniformity as compared to the 4-?m devices, which is due to the thinner tungsten (W) electrode as well as higher series resistance. The oxygen-rich TaO x layer at the W/TaO x interface also plays an important role in getting self-compliance resistive switching phenomena and non-linear current-voltage (I-V) curve at low resistance state (LRS). Switching mechanism is attributed to the formation and rupture of oxygen vacancy conducting path in the TaO x switching material. The memory device also exhibits long read endurance of >106 cycles. It is found that after 400,000 cycles, the high resistance state (HRS) is decreased, which may be due to some defects creation (or oxygen moves away) by frequent stress on the switching material. Good data retention of >104 s is also obtained.

2014-01-01

350

Assessment of plasma prothrombotic factors in patients with Buerger's disease.  

PubMed

The pathogenesis of Buerger' disease (thrombangiitis obliterans; TAO) remains unknown, although a strong association with tobacco use has been established. Blood coagulation and fibrinolytic factors as well as selected clinical chemistry parameters have been evaluated in 37 patients with Buerger's disease. Median levels of prothrombotic factors were higher in patients with TAO than in healthy control: annexin V (P?TAO than in control (P?TAO. PMID:23358197

Hus, Iwona; Sokolowska, Bozena; Walter-Croneck, Adam; Chrapko, Marek; Nowaczynska, Aleksandra; Dmoszynska, Anna

2013-03-01

351

Evaluation of ocean surface vector winds observed by QuikSCAT\\/seawinds and ADEOS-II\\/seawind  

Microsoft Academic Search

Ocean surface vector winds observed by QuikSCAT\\/SeaWinds and ADEOS-II\\/SeaWinds are evaluated by comparison with wind and wave data from the NDBC (National Data Buoy Center), TAO (Tropical Atmosphere and Ocean)\\/TRITON (Triangle Trans-Ocean buoy Network), PIRATA (Pilot Research Moored Array in the Tropical Atlantic), and JMA (Japan Meteorological Agency) buoys in the Atlantic and Pacific Oceans, Gulf of Mexico, and seas

Naoto Ebuchi; Hans C. Graber; Michael J. Caruso

2004-01-01

352

Evaluation of wind vectors observed by QuikSCAT\\/SeaWinds using ocean buoy data  

Microsoft Academic Search

Wind vectors observed by QuikSCAT\\/SeaWinds are compared with wind and wave data from offshore moored buoys. Effects of oceanographic and atmospheric parameters on the scatterometry are also assessed by using the buoy data. The QuikSCAT\\/SeaWinds Standard Wind Data Products (Level 2B) were collocated with the Japan Meteorological Agency (JMA), National Data Buoy Center (NDBC), and Tropical Atmosphere Ocean (TAO) buoys.

Naoto Ebuchi

2001-01-01

353

The equatorial undercurrent, meridional overturning circulation, and their roles in mass and heat exchanges during El Niño events in the tropical Pacific ocean  

Microsoft Academic Search

The equatorial undercurrent (EUC), the shallow meridional overturning cells feeding it, and their role in El Niño and decadal\\u000a variability in the equatorial Pacific are studied using both in situ data and an ocean general circulation model. Using temperature\\u000a and current data from the TAO\\/TRITON moorings at the equator, their data gaps are filled and it was shown that continuous

Takeshi Izumo

2005-01-01

354

THE SNOEK-KÖSTER RELAXATION IN BODY-CENTRED CUBIC METALS  

Microsoft Academic Search

(ISA) des pics de Snoek-Kôster (SK) apparaissent,après êcrouissage, à des tempéra­ tures beaucoup plus élevées que les pics de Snoek des ISA. La position et la hauteur du pic dépendent du degré d'êcrouissage et du teneur en ISA. Des expériences sur des monocristaux de Nb-O, Ta-O et Fe-N montrent clairement que deux processus de relaxation SK-1 (pic d'êcrouissage \\

M. Weller

1983-01-01

355

Climate change, wheat productivity and water use in the North China Plain: A new super-ensemble-based probabilistic projection  

Microsoft Academic Search

Ensemble-based probabilistic projection is an effective approach to deal with the uncertainties in climate change impact assessments and to inform adaptations. Here, the crop model MCWLA-Wheat was firstly developed by adapting the process-based general crop model, MCWLA [Tao, F., Yokozawa, M., Zhang, Z., 2009a. Modelling the impacts of weather and climate variability on crop productivity over a large area: a

Fulu Tao; Zhao Zhang

356

Multimedia ambience communication based on actual moving pictures in a steroscopic projection display environment  

Microsoft Academic Search

Multi-media Ambiance Project of TAO has been researching and developing an image space, that can be shared by people in different locations and can lend a real sense of presence. The image space is mainly based on photo-realistic texture, and some deformations which depend on human vision characteristics or pictorial expressions are being applied. We aim to accomplish shared-space communication

Kunio Yamada; Tadashi Ichikawa; Takeshi Naemura; Kiyoharu Aizawa; Shigeo Morishima; Takahiro Saito

2000-01-01

357

Numerical study of local heat transfer coefficient and fin efficiency of wavy fin-and-tube heat exchangers ? ? The present work is supported by the National Science Fund for Distinguished Young Scholars from the National Natural Science Foundation of China (No. 50425620), and the Key Grant Project of Chinese Ministry of Education (No. 306014)  

Microsoft Academic Search

Three-dimensional numerical simulations were performed for laminar flow of wavy fin-and-tube heat exchangers by using body-fitted coordinates (BFC) method with fin efficiency effect accounted. The prediction results of average Nusselt number, friction factor and fin efficiency were compared with the related experimental correlations [R.C. Xin, H.Z. Li, H.J. Kang, W. Li, W.Q. Tao, An experimental investigation on heat transfer and

Y. B. Tao; Y. L. He; J. Huang; Z. G. Wu; W. Q. Tao

2007-01-01

358

Ion beam deposition of tantalum pentoxide thin film at room temperature  

Microsoft Academic Search

Tantalum pentoxide (TaO) thin films have been deposited by reactive ion beam sputtering at room temperature. The films have been characterized by scanning electron microscopy, atomic force microscopy, x-ray photoelectron spectroscopy (XPS), Fourier transform infrared spectroscopy (FTIR), variable angle ellipsometry, and UV-VIS spectroscopy. The main parameter varied was the oxygen partial pressure. Stoichiometry is reached for p{sub O}{>=}3x10² Pa; within

W. Kulisch; D. Gilliland; G. Ceccone; H. Rauscher; L. Sirghi; P. Colpo; F. Rossi

2008-01-01

359

Titanium–aluminum oxynitride (TAON) as high- k gate dielectric for sub-32 nm CMOS technology  

Microsoft Academic Search

High-k insulators for the next generation (sub-32nm CMOS (complementary metal–oxide–semiconductor) technology), such as titanium–aluminum oxynitride (TAON) and titanium–aluminum oxide (TAO), have been obtained by Ti\\/Al e-beam evaporation, with additional electron cyclotron resonance (ECR) plasma oxynitridation and oxidation on Si substrates, respectively. Physical thickness values between 5.7 and 6.3nm were determined by ellipsometry. These films were used as gate insulators in

J. Miyoshi; J. A. Diniz; A. D. Barros; I. Doi; A. A. G. Von Zuben

2010-01-01

360

Phase transformation and negative thermal expansion in TaVO5.  

PubMed

Two phase transformations of TaVO(5) were observed by DSC and/or dilatometry measurements in the studied temperature range. X-ray diffraction and neutron powder diffraction structure refinements indicated a phase transformation at -14 °C from a monoclinic symmetry with space group P2(1)/c to an orthorhombic symmetry with space group Pnma above this temperature. The rigid TaO(6) octahedron in orthorhombic phase becomes nonregular at -14 °C, which results in the transition from Pnma to P2(1)/c. TaVO(5) was found to be a negative thermal expansion material above room temperature. The calculated volumetric thermal expansion coefficients (TECs) are -8.92 × 10(-6) °C(-1) in the range of 20-600 °C, and -2.19 × 10(-5) °C(-1) above 600 °C, respectively. The negative thermal expansion behavior is accounted for by the tilt of the TaO(6) and VO(4) polyhedra, where the shrinkage of the VO(4) tetrahedra result in the increase of Ta-O-V angles on heating, while the angle of Ta-O1-Ta maintains at 180° in the framework. PMID:21338086

Wang, Xiaowei; Huang, Qingzhen; Deng, Jinxia; Yu, Ranbo; Chen, Jun; Xing, Xianran

2011-03-21

361

Heat capacity, enthalpy and entropy of ternary bismuth tantalum oxides  

NASA Astrophysics Data System (ADS)

Heat capacity and enthalpy increments of ternary bismuth tantalum oxides Bi 4Ta 2O 11, Bi 7Ta 3O 18 and Bi 3TaO 7 were measured by the relaxation time method (2-280 K), DSC (265-353 K) and drop calorimetry (622-1322 K). Temperature dependencies of the molar heat capacity in the form Cpm =445.8+0.005451 T-7.489×10 6/ T2 J K -1 mol -1, Cpm =699.0+0.05276 T-9.956×10 6/ T2 J K -1 mol -1 and Cpm =251.6+0.06705 T-3.237×10 6/ T2 J K -1 mol -1 for Bi 3TaO 7, Bi 4Ta 2O 11 and for Bi 7Ta 3O 18, respectively, were derived by the least-squares method from the experimental data. The molar entropies at 298.15 K, S° m(298.15 K)=449.6±2.3 J K -1 mol -1 for Bi 4Ta 2O 11, S° m(298.15 K)=743.0±3.8 J K -1 mol -1 for Bi 7Ta 3O 18 and S° m(298.15 K)=304.3±1.6 J K -1 mol -1 for Bi 3TaO 7, were evaluated from the low-temperature heat capacity measurements.

Leitner, J.; Jakeš, V.; Sofer, Z.; Sedmidubský, D.; R?ži?ka, K.; Svoboda, P.

2011-02-01

362

Enhanced resistive switching memory characteristics and mechanism using a Ti nanolayer at the W/TaO x interface.  

PubMed

Enhanced resistive memory characteristics with 10,000 consecutive direct current switching cycles, long read pulse endurance of >10(5) cycles, and good data retention of >10(4) s with a good resistance ratio of >10(2) at 85°C are obtained using a Ti nanolayer to form a W/TiO x /TaO x /W structure under a low current operation of 80 ?A, while few switching cycles are observed for W/TaO x /W structure under a higher current compliance >300 ?A. The low resistance state decreases with increasing current compliances from 10 to 100 ?A, and the device could be operated at a low RESET current of 23 ?A. A small device size of 150?×?150 nm(2) is observed by transmission electron microscopy. The presence of oxygen-deficient TaO x nanofilament in a W/TiO x /TaO x /W structure after switching is investigated by Auger electron spectroscopy. Oxygen ion (negative charge) migration is found to lead to filament formation/rupture, and it is controlled by Ti nanolayer at the W/TaO x interface. Conducting nanofilament diameter is estimated to be 3 nm by a new method, indicating a high memory density of approximately equal to 100 Tbit/in.(2). PMID:24791160

Prakash, Amit; Maikap, Siddheswar; Chiu, Hsien-Chin; Tien, Ta-Chang; Lai, Chao-Sung

2014-01-01

363

Assessing mouse alternatives to access to computer: a case study of a user with cerebral palsy.  

PubMed

The purpose of this study is to describe the process of assessment of three assistive devices to meet the needs of a woman with cerebral palsy (CP) in order to provide her with computer access and use. The user has quadriplegic CP, with anarthria, using a syllabic keyboard. Devices were evaluated through a three-step approach: (a) use of a questionnaire to preselect potential assistive technologies, (b) use of an eTAO tool to determine the effectiveness of each devised, and (c) a conducting semi-structured interview to obtain qualitative data. Touch screen, joystick, and trackball were the preselected devices. The best device that met the user's needs and priorities was joystick. The finding was corroborated by both the eTAO tool and the semi-structured interview. Computers are a basic form of social participation. It is important to consider the special needs and priorities of users and to try different devices when undertaking a device-selection process. Environmental and personal factors have to be considered, as well. This leads to a need to evaluate new tools in order to provide the appropriate support. The eTAO could be a suitable instrument for this purpose. Additional research is also needed to understand how to better match devices with different user populations and how to comprehensively evaluate emerging technologies relative to users with disabilities. PMID:24800452

Pousada, Thais; Pareira, Javier; Groba, Betania; Nieto, Laura; Pazos, Alejandro

2014-01-01

364

Thromboangiitis Obliterans (Buerger's Disease)--Current Practices  

PubMed Central

Thromboangiitis obliterans (TAO) is a nonatherosclerotic, segmental inflammatory disease that most commonly affects the small and medium-sized arteries and veins in the upper and lower extremities. Cigarette smoking has been implicated as the main etiology of the disease. In eastern parts of the world TAO forms 40–60% of peripheral vascular diseases. Clinical features and angiographic finding are the basis of early diagnosis of TAO. Abstinence from smoking is the only definitive treatment to prevent disease progression. Medical management in form of aspirin, pentoxyfylline, cilostazol, and verapamil increase pain-free walking distance in intermittent claudication, but long term usage fails to prevent disease progression in patients who continue to smoke. Surgical treatment in form of revascularization, lumbar sympathectomy, omentopexy, and Ilizarov techniques help reduce pain and promote healing of trophic changes. Newer treatment modalities like spinal cord stimulation, prostacyclin, bosentan, VEGF, and stem cell therapy have shown promising results. Latest treatment options include peripheral mononuclear stem cell, and adipose tissue derived mononuclear stem cells have been shown to be effective in preventing disease progression, decrease major amputation rates, and improving quality of life.

Tiwari, Rahul; Kumar Prabhuswamy, Vinod

2013-01-01

365

Structural properties of InNbO 4 and InTaO 4: correlation with photocatalytic and photophysical properties  

NASA Astrophysics Data System (ADS)

The InTaO 4 and InNbO 4 photocatalysts were synthesized by solid-state reaction and characterized by powder X-ray diffraction and Rietveld structure refinement. These photocatalysts crystallize in the same wolframite structure and there are two kinds of octahedron, InO 6 and NbO 6(TaO 6), in a unit cell. The octahedral TaO 6 in InTaO 4 slightly expands from that of NbO 6 in InNbO 4, leading to the longer lattice parameters in InTaO 4. The band gaps of InTaO 4 and InNbO 4 were estimated to be 2.6 and 2.5 eV, respectively. The difference is due to conduction band levels formed by Ta 5d in TaO 6 and Nb 4d in NbO 6, resulting in a little difference in photocatalytic activity of the two compounds.

Zou, Zhigang; Ye, Jinhua; Arakawa, Hironori

2000-12-01

366

Petroleum coke adsorption as a water management option for oil sands process-affected water.  

PubMed

Water is integral to both operational and environmental aspects of the oil sands industry. A water treatment option based on the use of petroleum coke (PC), a by-product of bitumen upgrading, was examined as an opportunity to reduce site oil sands process-affected water (OSPW) inventories and net raw water demand. Changes in OSPW quality when treated with PC included increments in pH levels and concentrations of vanadium, molybdenum, and sulphate. Constituents that decreased in concentration after PC adsorption included total acid-extractable organics (TAO), bicarbonate, calcium, barium, magnesium, and strontium. Changes in naphthenic acids (NAs) speciation were observed after PC adsorption. A battery of bioassays was used to measure the OSPW toxicity. The results indicated that untreated OSPW was toxic towards Vibrio fischeri and rainbow trout. However, OSPW treated with PC at appropriate dosages was not acutely toxic towards these test organisms. Removal of TAO was found to be an adsorption process, fitting the Langmuir and Langmuir-Freundlich isotherm models. For TAO concentrations of 60 mg/L, adsorption capacities ranged between 0.1 and 0.46 mg/g. This study demonstrates that freshly produced PC from fluid cokers provides an effective treatment of OSPW in terms of key constituents' removal and toxicity reduction. PMID:22575375

Zubot, Warren; MacKinnon, Michael D; Chelme-Ayala, Pamela; Smith, Daniel W; Gamal El-Din, Mohamed

2012-06-15

367

Framework for bringing realistic virtual natural environments to distributed simulations  

NASA Astrophysics Data System (ADS)

One of the major new technical challenges for distributed simulations is the distribution and presentation and distribution of the natural atmosphere-ocean-space environment. The natural terrain environment has been a part of such simulations for a while, but the integration of atmosphere and ocean data and effects is quite new. The DARPA synthetic environments (SE) program has been developing and demonstrating advanced technologies for providing tactically significant atmosphere-ocean data and effects for a range of simulations. A general-purpose data collection, assimilation, management, and distribution system is being developed by the TAOS (Total Atmosphere-Ocean System) Project. This system is designed to support the new high level architecture (HLA)/run- time infrastructure (RTI) being developed by the Defense Modeling and Simulation Office (DMSO), as well as existing distributed interactive simulation (DIS) network protocols. This paper describes how synthetic natural environments are being integrated by TAOS to provide an increasingly rich dynamic synthetic natural environment. Architectural designs and implementations to accommodate a range of simulation applications are discussed. A number of enabling technologies are employed, such as the development of standards for gridded data distribution, and the inclusion of derived products and local environmental features within 4-dimensional data grids. The application of TAOS for training, analysis, and engineering simulations for sensor analysis is discussed.

Whitney, David A.; Reynolds, Robert A.; Olson, Stephen H.; Sherer, Dana Z.; Driscoll, Mavis L.; Watman, K. L.

1997-06-01

368

The role of oxidative stress on the pathogenesis of graves' disease.  

PubMed

Graves' disease is a most common cause of hyperthyroidism. It is an autoimmune disease, and autoimmune process induces an inflammatory reaction, and reactive oxygen species (ROSs) are among its products. When balance between oxidants and antioxidants is disturbed, in favour of the oxidants it is termed "oxidative stress" (OS). Increased OS characterizes Graves' disease. It seems that the level of OS is increased in subjects with Graves' ophthalmopathy compared to the other subjects with Graves' disease. Among the other factors, OS is involved in proliferation of orbital fibroblasts. Polymorphism of the 8-oxoG DNA N-glycosylase 1 (hOGG1) involved in repair of the oxidative damaged DNA increases in the risk for developing Grave's disease. Treatment with glucocorticoids reduces levels of OS markers. A recent large clinical trial evaluated effect of selenium on mild Graves' ophthalmopathy. Selenium treatment was associated with an improved quality of life and less eye involvement and slowed the progression of Graves' orbitopathy, compared to placebo. PMID:22175033

Zarkovi?, Miloš

2012-01-01

369

The Role of Oxidative Stress on the Pathogenesis of Graves' Disease  

PubMed Central

Graves' disease is a most common cause of hyperthyroidism. It is an autoimmune disease, and autoimmune process induces an inflammatory reaction, and reactive oxygen species (ROSs) are among its products. When balance between oxidants and antioxidants is disturbed, in favour of the oxidants it is termed “oxidative stress” (OS). Increased OS characterizes Graves' disease. It seems that the level of OS is increased in subjects with Graves' ophthalmopathy compared to the other subjects with Graves' disease. Among the other factors, OS is involved in proliferation of orbital fibroblasts. Polymorphism of the 8-oxoG DNA N-glycosylase 1 (hOGG1) involved in repair of the oxidative damaged DNA increases in the risk for developing Grave's disease. Treatment with glucocorticoids reduces levels of OS markers. A recent large clinical trial evaluated effect of selenium on mild Graves' ophthalmopathy. Selenium treatment was associated with an improved quality of life and less eye involvement and slowed the progression of Graves' orbitopathy, compared to placebo.

Zarkovic, Milos

2012-01-01

370

Diagnosis and classification of Graves' disease.  

PubMed

Graves' disease (GD) is an autoimmune disorder involving the thyroid gland, typically characterized by the presence of circulating autoantibodies that bind to and stimulate the thyroid hormone receptor (TSHR), resulting in hyperthyroidism and goiter. Organs other than the thyroid can also be affected, leading to the extrathyroidal manifestations of GD, namely Graves' ophthalmopathy, which is observed in ~50% of patients, and Graves' dermopathy and acropachy, which are quite rare. Presumably, the extrathyroidal manifestations of GD are due to autoimmunity against antigens common to the thyroid and other affected organs. Although its exact etiology remains to be completely understood, GD is believed to result from a complex interaction between genetic susceptibility and environmental factors. Clinically, GD is characterized by the manifestations of thyrotoxicosis as well as by its extrathyroidal features when present, the latter making the diagnosis almost unmistakable. In the absence of ophthalmopathy, the diagnosis is generally based on the association of hyperthyroidism and usually diffuse goiter confirmed with serum anti-TSHR autoantibodies (TRAbs). Hyperthyroidism is generally treated with anti-thyroid drugs, but a common long term treatment strategy in patients relapsing after a course of anti-thyroid drugs (60-70%), implies the use of radioactive iodine or surgery. PMID:24424182

Menconi, Francesca; Marcocci, Claudio; Marinò, Michele

2014-01-01

371

A LATE BRITTLE COMPONENT OF MOTION WITHIN THE DUCTILE EASTERN SIERRA CREST SHEAR ZONE (ESCSZ) ALONG THE EASTERN BOUNDARY OF THE TOLUMNE BATHOLITH IN THE SADDLEBAG LAKE, CA AREA. WHITESIDES, Andrew1, ENRIQUEZ, Marcus2 , HARDY, Jill1 , EHRET, Philip1, IANNONE, Monika1, CULBERT, Kristan1 GROSS, Ben3, LODEWYK, Jessica3, CAO, Wenrong1 , ZHANG, Tao1, MEMETI, Valbone3, PATERSON, Scott1 SCHMIDT, Keegan4. (1) Department of Earth Sciences, University of Southern California, Los Angeles, CA 90089-0740, awhitesi@usc.edu , (2) Department of Geological Sciences, Cal State L.A., 5151 State University Drive, Los Angeles, CA 90032, (3) Department of Earth and Planetary Sciences, Washington University, Campus Box 1169, 1 Brookings Dr, Saint Louis, MO, 63130, (4) Division of Natural Science and Mathematics, Lewis-Clark State College, 500 8th Ave., Lewiston, ID 83501  

NASA Astrophysics Data System (ADS)

During mapping (by the Undergraduate Team Research program, University of Southern California) in the Saddlebag Lake pendant just along the eastern margin of the Tuolumne batholith we have discovered a brittle slip component in the ESCSZ that juxtaposes largely metasedimentary and metavolcanic rock packages. The metasedimentary package is dominated by bedded sandstones and siltstones and local conglomerates whereas the metavolcanics show a large range of volcanic and volcaniclastic units. All of the units dip steeply and have an average N-NW strike. Dextral oblique ductile shear is distributed in domains in both rock packages with varying width from ~2 km in the South to ~1 km in the North. Shear sense in planes at high angles to a steep to SW plunging mineral lineation include S-C structures, shear bands, asymmetrical folding, sigma and delta clasts, and asymmetrical boudins. Partitioning of shear is common with the metarhyolites and metasediments showing higher non-coaxial strain than in the metaandesite and metadacite units. Map-scale “z-shaped” asymmetrical folds within the shear zone are also consistent with dextral shearing. Folded and sheared dikes of the 88-85 Ma Cathedral Peak phase of the Tuolumne batholith are common in the shear zone. A newly discovered brittle slip surface with breccias, gouge, and local pseudotachylite and large quartz veins was also mapped in the center of the ductile shear zone typically along the contact between the western metasedimentary and eastern metavolcanics (often a metarhyolite at the contact) on the east. Local slickenlines, steps, and offset dikes indicate that the brittle fault also had oblique dextral movement, similar to the ductile shear zone. In the mapped area no dikes originating from the TB cross the brittle fault and some are terminated at the brittle fault surface We interpret these observations to indicate northward displacement of the metasedimentary package by first ductile then brittle faulting during cooling and possibly uplift of this region with the youngest motion post 82 Ma.

Whitesides, A. S.; Enriquez, M.; Hardy, J.; Ehret, P.; Iannone, M.; Culbert, K. N.; Gross, M. B.; Lodewyk, J.; Cao, W.; Zhang, T.; Memeti, V.; Paterson, S. R.; Schmidt, K. L.

2009-12-01

372

Late Cretaceous to middle Tertiary tectonic history of the northern Rio Grande Rift, New Mexico  

NASA Astrophysics Data System (ADS)

Apatite fission track ages for samples collected from three mountain ranges on the eastern margin of the Rio Grande rift are used to examine the late Cretaceous to middle Miocene uplift and erosional history of north central New Mexico. The dates indicate that uplift and erosion was in progress in the Sandia Mountains near Albuquerque and in the Taos Range portion of the Sangre de Cristo Mountains near Taos at least 30-35 m.y. ago. Uplift and erosion continued in the Sandia Mountains at a relatively constant rate (81 m/m.y.) until 15 Ma; the rate of uplift and erosion in this area has approximately tripled in the past 15 m.y. (230 m/m.y.). Igneous activity in the Taos Range has largely obscured the early Tertiary uplift and erosional history of this portion of the Sangre de Cristo Mountains. A fission track date from one of the middle Tertiary intrusions in the Taos Range is used to calculate the cooling rate due to uplift and erosion in this area for the past 14 m.y. (210 m/m.y.). The uplift and erosion rates derived from the fission track data for the past 14-15 m.y. are similar to those obtained from other geological evidence. In contrast to the Oligocene to Miocene ages found in the other two areas, the apatite fission track ages from the Santa Fe Range portion of the Sangre de Cristo Mountains near Santa Fe are Late Cretaceous to early Eocene. These dates record the cooling of the area due to uplift and erosion during the Laramide event. The preservation of these older ages indicates that the Santa Fe Range was a low-lying area during the Oligocene to Miocene, while the surrounding areas (Sandia Mountains and Taos Range) underwent uplift and erosion. Volcanic activity occurred in the vicinity of the two areas of positive relief. Localized crustal extension associated with the volcanism may have contributed, in part, to the uplift of these areas. Using simple, two-dimensional thermal models, we found that the apparent denudation rates derived from the fission track age data may represent true denudation rates, given certain geologic conditions that may have existed during the uplift and erosion of the Sandia Mountains in the middle Tertiary and the Santa Fe Range in the late Cretaceous.

Kelley, Shari A.; Duncan, Ian J.

1986-05-01

373

Granular L10 FePt:X (X = Ag, B, C, SiOx, TaOx) thin films for heat assisted magnetic recording  

NASA Astrophysics Data System (ADS)

Ordered L10 FePt thin films are of interest as potential Heat Assisted Magnetic Recording media. In order to achieve the microstructure and magnetic properties to support recording at densities beyond 1 Tbit/in2, it is necessary to add segregants into the FePt films. In this work, the effects of a number of segregants, X, on the microstructure and magnetic properties of FePt:X (X = Ag, B, C, SiO x , TaO x ) thin films, deposited by RF sputtering with various volume content (0-50%), various in-situ heating temperatures (450-600 °C), various Ar pressures (10-40 mtorr) and various sputtering powers (25-200 W) onto 1'' Si substrates with a MgO texture (002) underlayer (20 nm), were investigated. It was observed that introducing segregants (B, C, SiO x , and TaO x ) into the FePt reduced ordering and grain size of the FePt:X thin films. Ag was found to offset the reduction of ordering in the FePt:X films. The B, SiO x and TaO x promoted columnar growth whereas C promoted a secondary nucleation layer but produced the least reduction of ordering. By varying the volume content of the segregants, the grain size of the FePt:X can be controllably reduced throughout the 2.5-10 nm range. It was found that TaO x produced the best exchange decoupling, thermal durability, grain isolation and hindered grain coalescence as compared with the films deposited with B, C or SiO x . With the FePt:C:Ag films sputtered at 450 °C, a perpendicular coercivity measured at room temperature as high as 25 kOe was achieved; whereas with B, SiO x , and TaO x , perpendicular coercivities as high as 11 kOe were obtained. These FePt:X thin films with small grain size, columnar microstructure and high coercivity are believed to be favorable for application in Heat Assisted Magnetic Recording. The role of surface energies of FePt and the segregant in columnar growth of FePt grains is discussed.

Granz, Steven D.; Barmak, Katayun; Kryder, Mark H.

2013-03-01

374

Management of Graves' disease: an overview and comparison of clinical practice guidelines with actual practice trends.  

PubMed

Over the last century, much has been learned about the pathogenesis, manifestations, and management of Graves' disease leading to the establishment of evidence-based clinical practice guidelines. The joint clinical practice guidelines from the American Thyroid Association and the American Association of Clinical Endocrinologists give recommendations on both the diagnosis and treatment of hyperthyroidism. A survey of clinicians performed that same year, however, revealed that current practices diverge from these recently published guidelines in multiple areas. These differences will need to be assessed serially to determine the impact of the guidelines on future clinical practice and perhaps vice versa. PMID:24891174

Muldoon, Becky T; Mai, Vinh Q; Burch, Henry B

2014-06-01

375

Genetic susceptibility to Grave's disease.  

PubMed

The variety of clinical presentations of eye changes in patients with Graves' disease (GD) suggests that complex interactions between genetic, environmental, endogenous and local factors influence the severity of Graves' ophthalmopathy (GO). It is thought that the development of GO might be influenced by genetic factors and environmental factors, such as cigarette smoking. At present, however, the role of genetic factors in the development of GO is not known. On the basis of studies with candidate genes and other genetic approaches, several susceptibility loci in GO have been proposed, including immunological genes, human leukocyte antigen (HLA), cytotoxic T-lymphocyte antigen-4 (CTLA-4), regulatory T-cell genes and thyroid-specific genes. This review gives a brief overview of the current range of major susceptibility genes found for GD. PMID:23747868

Li, Hong; Chen, Qiuying

2013-01-01

376

Inferior rectus palsy as an isolated ocular motor sign: acquired etiologies and outcome.  

PubMed

The aim of this work is to elucidate underlying etiologies, lesion locations, and outcomes of inferior rectus (IR) palsy of acquired origin. Retrospective search identified 44 patients with acquired IR palsy between April 2006 and May 2011 from four Neurology and two Ophthalmology Clinics in Korea. We analyzed clinical features, the results of radiological and laboratory evaluation, and prognosis. The most common causes were vascular (n = 16, 36 %) and trauma (n = 12, 27 %). Vascular disorders included microvascular ischemia (n = 10, 23 %), cerebral infarction (n = 5, 11 %), and dural arterio-venous fistula (n = 1, 2 %). Other causes were inflammation (n = 7, 16 %), myasthenia gravis (n = 5, 11 %), and thyroid ophthalmopathy (n = 1, 2 %). We were unable to determine the etiology in the remaining three patients (7 %). Most patients (95 %) showed a complete recovery with or without treatment. Acquired IR palsy mostly occurs with brainstem or orbital lesions, and has an excellent prognosis. PMID:22743791

Choi, Kwang-Dong; Choi, Jae-Hwan; Choi, Hee Young; Huh, Young-Eun; Kim, Hyo Jung; Oh, Sun-Young; Jeong, Seong-Hae; Hwang, Jeong-Min; Kim, Ji Soo

2013-01-01

377

Rhabdomyolysis Induced by Nonstrenuous Exercise in a Patient with Graves' Disease  

PubMed Central

Hyperthyroidism can result in several musculoskeletal conditions such as thyrotoxic periodic paralysis, thyrotoxic myopathy, and thyroid ophthalmopathy. Rhabdomyolysis has been rarely reported to be associated with hyperthyroidism. We describe a 33-year-old man who presented with bilateral thigh pain and dark brown urine after regular squatting. He had a past medical history of hyperthyroidism but stopped taking it 2 months prior to admission. He was found to have rhabdomyolysis, myoglobinuria, and thyrotoxicosis. Presence of thyroid-stimulating immunoglobulins (TSI) and high radioiodine uptake confirmed a diagnosis of Graves' disease. He received aggressive fluid resuscitation and sodium bicarbonate intravenously along with monitoring fluid and electrolyte. Methimazole was also resumed. The patient responded to treatment and rhabdomyolysis gradually resolved. Therefore, nonstrenuous exercise can potentially induce rhabdomyolysis in patients with hyperthyroidism. Although hyperthyroidism is not widely recognized as a cause of rhabdomyolysis, it should be considered in the differential diagnosis of rhabdomyolysis.

Summachiwakij, Sarawut

2014-01-01

378

Rhabdomyolysis induced by nonstrenuous exercise in a patient with graves' disease.  

PubMed

Hyperthyroidism can result in several musculoskeletal conditions such as thyrotoxic periodic paralysis, thyrotoxic myopathy, and thyroid ophthalmopathy. Rhabdomyolysis has been rarely reported to be associated with hyperthyroidism. We describe a 33-year-old man who presented with bilateral thigh pain and dark brown urine after regular squatting. He had a past medical history of hyperthyroidism but stopped taking it 2 months prior to admission. He was found to have rhabdomyolysis, myoglobinuria, and thyrotoxicosis. Presence of thyroid-stimulating immunoglobulins (TSI) and high radioiodine uptake confirmed a diagnosis of Graves' disease. He received aggressive fluid resuscitation and sodium bicarbonate intravenously along with monitoring fluid and electrolyte. Methimazole was also resumed. The patient responded to treatment and rhabdomyolysis gradually resolved. Therefore, nonstrenuous exercise can potentially induce rhabdomyolysis in patients with hyperthyroidism. Although hyperthyroidism is not widely recognized as a cause of rhabdomyolysis, it should be considered in the differential diagnosis of rhabdomyolysis. PMID:24716006

Summachiwakij, Sarawut; Sachmechi, Issac

2014-01-01

379

[Extraocular myositis and comparative pathology: two case reports in the dog].  

PubMed

Two cases of extraocular myositis in dogs are reported in a golden retriever and an Australian shepherd. This condition is characterized by sudden bilateral exophthalmos, the absence of pain and third eyelid protrusion, orbital sonography showing the enlargement of extraocular muscles, and a quick response to systemic steroids at an anti-inflammatory dose. The literature review reports a breed predisposition in the golden retriever, mainly in females. Histopathologic evaluations confirm the inflammation of one or several extraocular muscles. Chronic disease was also described. Canine extraocular myositis shows some resemblance to Graves ophthalmopathy but can better be compared to idiopathic orbital myositis. Both disorders are probably the consequence of an immune dysfunction that still has to be discovered. PMID:21658791

Azoulay, T; Jongh, O

2011-12-01

380

Dilated episcleral veins with secondary open angle glaucoma  

PubMed Central

We report a case of dilated episcleral vein with secondary open angle glaucoma. A 65-year-old female presented with redness of both the eyes without any prior systemic history. Her ocular examination revealed dilated episcleral veins and a high intraocular pressure (IOP) of 38 mm Hg in the right eye. Systemic examination was negative for carotid cavernous fistula, low-grade dural arteriovenous fistula, dysthyroid ophthalmopathy, and primary pulmonary hypertension. During follow-up, her IOP remained in high thirties despite maximum medications. She underwent right eye trabeculectomy with partial thickness sclerectomy with sclerotomy. In the beginning, the sclerotomy incision was not deepened into the suprachoroidal space. She developed choroidal effusion during surgery and the sclerotomy was deepened into suprachoroidal space and straw color fluid was drained. Postoperatively, she developed choroidal effusion, which resolved with conservative management. This case highlights the importance of sclerotomy in such cases of high episcleral venous pressure.

Parikh, Rajul S; Desai, Savari; Kothari, Kulin

2011-01-01

381

The use of autogenous fascia lata to correct lid and orbital deformities.  

PubMed Central

Autogenous and homologous fascia lata have been used to correct many problems in ophthalmic surgery. This paper has described the use of autogenous fascia late to correct lid retraction secondary to thyroid ophthalmopathy, cicatricial entropion and extruding orbital implants. The surgical procedures have been briefly discussed, as well as the presentation of one clinical example of each procedure the pathologic and immunologic aspects of fascia lata grafts will be reported at a later date. Images FIGURE 1 A FIGURE 1 B FIGURE 1 C FIGURE 1 D FIGURE 1 E FIGURE 1 F FIGURE 2 A FIGURE 2 B FIGURE 2 C FIGURE 2 D FIGURE 3 A FIGURE 3 B FIGURE 3 C FIGURE 4 FIGURE 5 A FIGURE 5 B FIGURE 5 C FIGURE 6 A FIGURE 6 B FIGURE 6 C FIGURE 6 D FIGURE 7 A FIGURE 7 B FIGURE 7 C

Flanagan, J C; Campbell, C B

1981-01-01

382

A rare case of orbital involvement in Riedel's thyroiditis.  

PubMed

We report a case of Riedel's thyroiditis in a 59-yr-old Caucasian female. She presented hypothyroidism and a stony hard, painful goiter. Due to fever, a high sedimentation rate and a high C-reactive protein (CRP), as well as high levels of anti-thyroid peroxidase antibodies (anti-TPOab), differential diagnostic considerations included acute and subacute thyroiditis as well as Hashimoto's thyroiditis and thyroid malignancy. At the same time the patient had clinical and radiological features of bilateral orbital pseudotumor with lacrimal gland involvement. During L-thyroxine therapy orbital symptoms and signs improved and thyroid size decreased. This case report serves as a reminder of differential diagnostic considerations in the etiology of goiter as well as ophthalmopathy. Although extremely rare, orbital sclerosing fibrosis can be seen in conjunction with Riedel's thyroiditis as part of multifocal fibrosclerosis. PMID:14759078

Egsgaard Nielsen, V; Hecht, P; Krogdahl, A S; Andersen, P B; Hegedüs, L

2003-10-01

383

Slip Rate Determination of Thrusts Along the Edge of NE Tibet From in situ-Produced Cosmogenic Nuclides  

NASA Astrophysics Data System (ADS)

The Qilian Shan forms a seismically active fold-and-thrust-belt along the NE margin of the Tibetan Plateau that evolved during the Neogene-Quaternary and continues to advance north-northeastward (Meyer et al., 1998; Tapponnier et al., 2001). Active thrust faults transecting Late Pleistocene alluvial fan deposits form spectacular fault scarps that are locally incised by rivers which form flights of terraces. By combining structural investigations, satellite imagery, topographic profiling, surface exposure, and luminescence dating we have determined slip rates for several thrust faults (Hetzel et al. 2002, 2004a,b). Our results are consistent with geologic and GPS constraints, which suggest that NNE-directed shortening across the northeastern Tibetan Plateau is distributed on several active faults with a total shortening rate of about 4 to 10 mm/yr. References Hetzel, R., S. Niedermann, M. Tao, P.W. Kubik, S. Ivy-Ochs, B. Gao, M.R. Strecker (2002a), Nature, 417, 428-432. Hetzel, R., M. Tao, S. Niedermann, M.R. Strecker, S. Ivy-Ochs, P.W. Kubik, B. Gao (2004a), Terra Nova 16, 157-162. Hetzel R., M. Tao, S. Stokes, S. Niedermann, S. Ivy-Ochs, G. Bo, M.R. Strecker, P.W. Kubik (2004b), Tectonics 23, TC6006, doi:10.1029/2004TC001653. Meyer, B., P. Tapponnier, L. Bourjot, F. Metivier, Y. Gaudemer, G. Peltzer, G. Shunmin, C. Zhitai (1998), Geophys. J. Int., 135, 1-47. Tapponnier, P., Z. Xu, F. Roger, B. Meyer, N. Arnaud, G. Wittlinger, J. Yang (2001), Science, 294, 1671-1677.

Hetzel, R.; Niedermann, S.; Tao, M.; Ivy-Ochs, S.; Stokes, S.; Strecker, M. R.; Kubik, P. W.

2005-12-01

384

The Teleost Anatomy Ontology: Anatomical Representation for the Genomics Age  

PubMed Central

The rich knowledge of morphological variation among organisms reported in the systematic literature has remained in free-text format, impractical for use in large-scale synthetic phylogenetic work. This noncomputable format has also precluded linkage to the large knowledgebase of genomic, genetic, developmental, and phenotype data in model organism databases. We have undertaken an effort to prototype a curated, ontology-based evolutionary morphology database that maps to these genetic databases (http://kb.phenoscape.org) to facilitate investigation into the mechanistic basis and evolution of phenotypic diversity. Among the first requirements in establishing this database was the development of a multispecies anatomy ontology with the goal of capturing anatomical data in a systematic and computable manner. An ontology is a formal representation of a set of concepts with defined relationships between those concepts. Multispecies anatomy ontologies in particular are an efficient way to represent the diversity of morphological structures in a clade of organisms, but they present challenges in their development relative to single-species anatomy ontologies. Here, we describe the Teleost Anatomy Ontology (TAO), a multispecies anatomy ontology for teleost fishes derived from the Zebrafish Anatomical Ontology (ZFA) for the purpose of annotating varying morphological features across species. To facilitate interoperability with other anatomy ontologies, TAO uses the Common Anatomy Reference Ontology as a template for its upper level nodes, and TAO and ZFA are synchronized, with zebrafish terms specified as subtypes of teleost terms. We found that the details of ontology architecture have ramifications for querying, and we present general challenges in developing a multispecies anatomy ontology, including refinement of definitions, taxon-specific relationships among terms, and representation of taxonomically variable developmental pathways.

Dahdul, Wasila M.; Lundberg, John G.; Midford, Peter E.; Balhoff, James P.; Lapp, Hilmar; Vision, Todd J.; Haendel, Melissa A.; Westerfield, Monte; Mabee, Paula M.

2010-01-01

385

Validation of the temporal ocean mass variations from GRACE with in-situ observation  

NASA Astrophysics Data System (ADS)

We validated the GRACE-derived temporal ocean mass variations from the period 2002.8-2004.8 with the two independent sets of in-situ observations. One set is the ocean mass variations at the TAO-TRITON moored-buoys. In this case, the ocean mass variations are obtained by subtracting the steric sea level changes estimated from the temperature profile measurements from the altimetric sea level changes. The other set is the ocean mass variations measured by the Bottom Pressure Recorders (BPRs) in the Deep-ocean Assessment and Reporting of Tsunamis (DART) array. Prior to the comparison, the degree-one Stokes_f coefficients are estimated to minimize the GRACE-derived and in-situ variations in the least-square sense. After adjusting for the degree-one Stokes_f component, we find that the ocean mass variations from GRACE correlate significantly with the in-situ variations. At the TAO-TRITON buoys, the GRACE-derived variations and in-situ variations have the correlation coefficient of 0.61 and the admittance 0.95+-0.04. At the DART BPRs, they have the correlation coefficient of 0.65 and the admittance 0.83+-0.14. The obtained degree-one Stokes_f coefficients in terms of the geocenter motions generally agree with those derived from the SLR observations. However, adopting the SLR-derived values for degree-one Stokes_f coefficients results in the degradation of the correlations, namely, to 0.23 at the TAO-TRITON buoys and to 0.08 at the DART BPRs. These results confirm the validity of the GRACE-derived ocean mass variations, and also show the possibility of using the comparison as a mean to estimate precise geocenter motions comparable to those derived from other space techniques.

Munekane, H.

2005-12-01

386

First-principles density functional calculation of electrochemical stability of fast Li ion conducting garnet-type oxides.  

PubMed

The research and development of rechargeable all-ceramic lithium batteries are vital to realize their considerable advantages over existing commercial lithium ion batteries in terms of size, energy density, and safety. A key part of such effort is the development of solid-state electrolyte materials with high Li(+) conductivity and good electrochemical stability; lithium-containing oxides with a garnet-type structure are known to satisfy the requirements to achieve both features. Using first-principles density functional theory (DFT), we investigated the electrochemical stability of garnet-type Li(x)La(3)M(2)O(12) (M = Ti, Zr, Nb, Ta, Sb, Bi; x = 5 or 7) materials against Li metal. We found that the electrochemical stability of such materials depends on their composition and structure. The electrochemical stability against Li metal was improved when a cation M was chosen with a low effective nuclear charge, that is, with a high screening constant for an unoccupied orbital. In fact, both our computational and experimental results show that Li(7)La(3)Zr(2)O(12) and Li(5)La(3)Ta(2)O(12) are inert to Li metal. In addition, the linkage of MO(6) octahedra in the crystal structure affects the electrochemical stability. For example, perovskite-type La(1/3)TaO(3) was found, both experimentally and computationally, to react with Li metal owing to the corner-sharing MO(6) octahedral network of La(1/3)TaO(3), even though it has the same constituent elements as garnet-type Li(5)La(3)Ta(2)O(12) (which is inert to Li metal and features isolated TaO(6) octahedra). PMID:22711381

Nakayama, Masanobu; Kotobuki, Masashi; Munakata, Hirokazu; Nogami, Masayuki; Kanamura, Kiyoshi

2012-07-28

387

Alternative schemes for production of chilled water and cogeneration of electricity at Ashley Plant  

SciTech Connect

William Tao Associates, Inc. (TAO) evaluated alternative systems for the generation of Chilled Water at Ashley Plant. The generation of chilled water is necessary for several reason; initially as a source of revenue for St. Louis Thermal Energy Corporation (SLTEC), but more importantly as a necessary component of the Trash-to-Energy Plant proposed north of Ashley Plant. The chilled water system provides a base load for steam generated by the Trash-to-Energy Plant. The benefits include reduced tip-fees to the City of St. Louis, lower cost of energy to customers of both the district steam system and the proposed chilled water system, and will result in lower energy and operating costs for the system than if individual services are provided. This symbiotic relationship is main advantage of the Trash-to-Energy system. TAO provided preliminary engineering of the chilled water line route. The basic assumptions of an initial load of 10,000 tons with an ultimate load of 20,000 tons at a temperature difference of 16{degree}F remain. The findings of the pipeline study, although not incorporated into this document, remain valid. Assumptions include the following: An initial design load of 6000 tons which has the capability of growing to 20,000 tons; Incremental costs of steam generated by Ashley Plant and the Trash-to-Energy plant; The turbine room at Ashley Plant is suitable for gut rehab except for turbines No. 7 and No. 9 which should remain operational; and Daily chilled water flow and annual load profile. The paper describes the findings on 8 alternative chiller systems. Additional studies were performed on the following: chilled water storage; low-pressure absorption chiller for balancing plant steam loads; economizer cycle for chiller system; auxiliary equipment energy source; variable flow water pumps; and comparison to satellite chilled water plant study.

Not Available

1989-01-01

388

Substitutional mechanism of Ni into the wide-band-gap semiconductor InTaO4 and its implications for water splitting activity in the wolframite structure type.  

PubMed

The mechanism of Ni substitution into the oxide semiconductor InTaO(4) has been studied through a combination of structural and spectroscopic techniques, providing insights into its previously reported photoactivity. Magnetic susceptibility and X-ray absorption near-edge spectroscopy (XANES) measurements demonstrate that nickel is divalent within the host lattice. The combined refinement of synchrotron X-ray and neutron powder diffraction data indicates that the product of Ni doping has the stoichiometry of (In(1-x)Ni(2x/3)Ta(x/3))TaO(4) with a solubility limit of x ? 0.18, corresponding to 12% Ni on the In site. Single-phase samples were only obtained at synthesis temperatures of 1150 °C or higher due to the sluggish reaction mechanism that is hypothesized to result from small free energy differences between (In(1-x)Ni(2x/3)Ta(x/3))TaO(4) compounds with different x values. Undoped InTaO(4) is shown to have an indirect band gap of 3.96 eV, with direct optical transitions becoming allowed at photon energies in excess of 5.1 eV. Very small band-gap reductions (less than 0.2 eV) result from Ni doping, and the origin of the yellow color of (In(1-x)Ni(2x/3)Ta(x/3))TaO(4) compounds instead results from a weak (3)A(2g) ? (3)T(1g) internal d ? d transition not associated with the conduction or valence band that is common to oxide compounds with Ni(2+) in an octahedral environment. PMID:22530995

Malingowski, Andrew C; Stephens, Peter W; Huq, Ashfia; Huang, Qingzhen; Khalid, Syed; Khalifah, Peter G

2012-06-01

389

Smoking and thyroid.  

PubMed

Current smoking in population surveys is associated with a slight dose-dependent fall of serum TSH, likely secondary to a rise of serum FT4 and FT3 induced by activation of the sympathetic nervous system; it is independent of iodine intake. In contrast, the slightly greater thyroid size in smokers is observed in iodine-deficient but not in iodine-sufficient areas and caused by competitive inhibition of thyroidal iodide uptake by thiocyanate. Smokers have an increased prevalence of nontoxic goitre and thyroid multinodularity, at least in iodine-deficient areas. Current smoking reduces dose dependently the risk of thyroid cancer, which is more pronounced for papillary than for follicular types; the risk in former smokers approaches that of never smokers. The lower TSH and lower body mass index in smokers might contribute to this reduced risk. Current smoking lowers the risk of developing thyroid peroxidase and thyroglobulin antibodies and subclinical and overt autoimmune hypothyroidism; the effect is dose dependent, but disappears within 3 years after quitting smoking. There is evidence from an animal model of experimental autoimmune thyroiditis that anti-inflammatory effects of nicotine are involved. In contrast, smoking is a dose-dependent risk factor for Graves' hyperthyroidism and especially for Graves' ophthalmopathy. Smoking is related to a higher recurrence rate of Graves' hyperthyroidism, a higher risk on Graves' ophthalmopathy after 131I therapy and a less favourable outcome of GO treatment with steroids or retrobulbar irradiation. The observed associations with smoking likely indicate causal relationships in view of consistent associations across studies, the presence of dose-response effects and disappearance of associations after cessation of smoking. PMID:23581474

Wiersinga, Wilmar M

2013-08-01

390

Pregnancy-associated osteoporosis with a heterozygous deactivating LDL receptor-related protein 5 (LRP5) mutation and a homozygous methylenetetrahydrofolate reductase (MTHFR) polymorphism.  

PubMed

Pregnancy-associated osteoporosis (PAO) is a rare, idiopathic disorder that usually presents with vertebral compression fractures (VCFs) within 6 months of a first pregnancy and delivery. Spontaneous improvement is typical. There is no known genetic basis for PAO. A 26-year-old primagravida with a neonatal history of unilateral blindness attributable to hyperplastic primary vitreous sustained postpartum VCFs consistent with PAO. Her low bone mineral density (BMD) seemed to respond to vitamin D and calcium therapy, with no fractures after her next successful pregnancy. Investigation of subsequent fetal losses revealed homozygosity for the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism associated both with fetal loss and with osteoporosis (OP). Because her neonatal unilateral blindness and OP were suggestive of loss-of-function mutation(s) in the gene that encodes LDL receptor-related protein 5 (LRP5), LRP5 exon and splice site sequencing was also performed. This revealed a unique heterozygous 12-bp deletion in exon 21 (c.4454_4465del, p.1485_1488del SSSS) in the patient, her mother and sons, but not her father or brother. Her mother had a normal BMD, no history of fractures, PAO, ophthalmopathy, or fetal loss. Her two sons had no ophthalmopathy and no skeletal issues. Her osteoporotic father (with a family history of blindness) and brother had low BMDs first documented at ages ?40 and 32 years, respectively. Serum biochemical and bone turnover studies were unremarkable in all subjects. We postulate that our patient's heterozygous LRP5 mutation together with her homozygous MTHFR polymorphism likely predisposed her to low peak BMD. However, OP did not cosegregate in her family with the LRP5 mutation, the homozygous MTHFR polymorphism, or even the combination of the two, implicating additional genetic or nongenetic factors in her PAO. Nevertheless, exploration for potential genetic contributions to PAO may explain part of the pathogenesis of this enigmatic disorder and identify some at-risk women. PMID:24014470

Cook, Fiona J; Mumm, Steven; Whyte, Michael P; Wenkert, Deborah

2014-04-01

391

El Nino Theme Page: Access to Distributed Information on El Nino  

NSDL National Science Digital Library

This concentrated, in-depth resource provides access to recent information on El Nino Southern Oscillation (ENSO) and La Nina in the Pacific Ocean, including data, graphics, forecasts, historical perspectives, in-depth analyses, prediction benefits, impacts on human life, and information on the 1997/1999 El Nino and La Nina events. Links to relevant data include Tropical Atmosphere Ocean Project (TAO) moored buoy data, XBT data, drifting buoy data, sea level field analyses, real-time data and analyses, satellite data, climate data, numerical model simulations and Ka'Imimoana shipboard data. The site also includes 3D animations and links to theme pages in Spanish, French, and Portuguese.

392

The Supernova Legacy Survey: Measurement of Omega_M, Omega_Lambda, and w from the First Year Data Set  

DOE R&D Accomplishments Database

Astier, P.; Guy, J.; Regnault, N.; Pain, R.; Aubourg, E.; Balam, D.; Basa, S.; Carlberg, R. G.; Fabbro, S.; Fouchez, D.; Hook, I. M.; Howell, D. A.; Lafoux, H.; Neill, J. D.; Palanque-Delabrouille, N.; Perrett, K.; Pritchet, C. J.; Rich, J.; Sullivan, M.; Taillet, R.; Aldering, G.; Antilogus, P.; Arsenijevic, V.; Balland, C.; Baumont, S.; Bronder, J.; Courtois, H.; Ellis, R. S.; Filiol, M.; Goncalves, A. C.; Goobar, A.; Guide, D.; Hardin, D.; Lusset, V.; Lidman, C.; McMahon, R.; Mouchet, M.; Mourao, A.; Perlmutter, S.; Ripoche, P.; Tao, C.; Walton, N.; October 14, 2005; LBNL--59164; ACC0428

2005-10-14

393

An Extended Kalman Filter to Assimilate Altimetric Data into a Non-Linear Model of the Tropical Pacific  

NASA Technical Reports Server (NTRS)

A new implementation of the extended Kaman filter is developed for the purpose of assimilating altimetric observations into a primitive equation model of the tropical Pacific. Its specificity consists in defining the errors into a reduced basis that evolves in time with the model dynamic. Validation by twin experiments is conducted and the method is shown to be efficient in quasi real conditions. Data from the first 2 years of the Topex/Poseidon mission are assimilated into the Gent & Cane [1989] model. Assimilation results are evaluated against independent in situ data, namely TAO mooring observations.

Gourdeau, L.; Verron, J.; Murtugudde, R.; Busalacchi, A. J.

1997-01-01

394

Ocean and Weather Data Navigator  

NSDL National Science Digital Library

This interactive map viewer allows users to visualize and download in-situ oceanographic or atmospheric data from a Dapper OpenDap server. The map can be zoomed or dragged, with an in-situ station layer that allows selection of data stations, and a plot window that allows users to plot data from one or more stations. Datasets (temperature, salinity, current, chemistry) include realtime global Argo data, Tropical Atmosphere Ocean (TAO) Project El Nino buoy data, time series data from the National Data Buoy Center, Global Summary of the Day data, and other collections of oceanographic hydrographic and time series data.

395

Assessing genetic diversity of Vietnamese local chicken breeds using microsatellites.  

PubMed

This study aimed to assess genetic diversity within and between nine Vietnamese local chicken breeds and two Chinese breeds included for comparison. Genotyping 29 microsatellites revealed high diversity of both Vietnamese and Chinese breeds. Cluster analysis using the STRUCTURE software suggested six clusters as the most likely grouping of the 11 breeds studied. These groups encompassed four homogeneous clusters, one formed by the two Chinese breeds and the other three representing a single breed each: the Mekong Delta breed Ac, the South Central Coast breed Choi, and the Red River Delta breed Dong Tao. The six remaining breeds formed two additional admixed clusters. PMID:20394606

Cuc, N T K; Simianer, H; Eding, H; Tieu, H V; Cuong, V C; Wollny, C B A; Groeneveld, L F; Weigend, S

2010-10-01

396

Extended X-ray absorption fine structure, X-ray diffraction and Raman analysis of nickel-doped Ba(Mg 1\\/3Ta 2\\/3)O 3  

Microsoft Academic Search

Raman, X-ray diffraction and extended X-ray absorption fine structure (EXAFS) measurements of xBa(Ni1\\/3Ta2\\/3)O3+(1?x)Ba(Mg1\\/3Ta2\\/3)O3 samples with x=0–0.03 were performed to reveal the nickel doping effect on the microwave properties. EXAFS result clearly shows that the nickel is located on the Mg lattice site. We also found that, as the nickel concentration increases, microwave dielectric constant decreases with the TaO and NiO

Mei Yu Chen; P. J. Chang; C. T. Chia; Y. C. Lee; I. N. Lin; L.-J. Lin; J. F. Lee; H. Y. Lee; T. Shimada

2007-01-01

397

Neutron diffusion in a randomly inhomogeneous multiplying medium with random phase approximation  

SciTech Connect

Neutron diffusion in a randomly inhomogeneous multiplying medium is studied. By making use of a random phase assumption we show that the average neutron density approximately satisfies an integral equation in Fourier space, which is solved using Kummer functions. We used multi-dimensional formulation. In the case of one dimension, we obtain the result of Rosenbluth and Tao for the mean total density for large t. In the three-dimensional case, a closed form of solution is derived for the mean total neutron density. Its asymptotic behavior is also investigated for large t.

Imre, Kaya [Courant Institute of Mathematical Sciences, New York University, New York 10012 (United States); Akcasu, A. Ziya [University of Michigan, Ann Arbor, Michigan 48109 (United States)

2012-06-15

398

Self-consistent meta-generalized gradient approximation within the projector-augmented-wave method  

Microsoft Academic Search

The Tao-Perdew-Staroverov-Scuseria (TPSS) meta-generalized-gradient-approximation (MGGA) and its revised version, the revTPSS, are implemented self-consistently within the framework of the projector-augmented-wave (PAW) method, using a plane wave basis set. Both TPSS and revTPSS yield accurate atomization energies for the molecules in the AE6 set, better than those of the standard Perdew-Burke-Ernzerhof (PBE) generalized-gradient-approximation. For lattice constants and bulk moduli of 20

Jianwei Sun; Martijn Marsman; Gábor I. Csonka; Adrienn Ruzsinszky; Pan Hao; Yoon-Suk Kim; Georg Kresse; John P. Perdew

2011-01-01

399

Luminescent properties of GdTaO 4 and GdTaO 4 : Eu 3+ under VUV–UV excitation  

Microsoft Academic Search

The luminescent properties of GdTaO4 and GdTaO4:Eu3+ were investigated using synchrotron radiation VUV–UV source. Broad-band emissions peaked at 384 and 468 nm due to the TaO4 group and 6PJ?8S7\\/2 emission of Gd3+ at 316 nm under the UV excitation are found at 20 K, but quenched at room temperature. The excitation spectra of GdTaO4:Eu3+ monitoring the 5D0?7F2 emission of Eu3+

Bo Liu; Kun Han; Xiaolin Liu; Mu Gu; Shiming Huang; Chen Ni; Zeming Qi; Guobin Zhang

2007-01-01

400

Conduction centers in a Ta2O5-? Fermi glass  

NASA Astrophysics Data System (ADS)

We compare our photoemission spectra with the calculated energy spectra of oxygen vacancies in Ta oxide to identify the defects responsible for the formation of a band in the gap of a Ta oxide-based memristor. We have previously explained transitions between high and low resistance states in a memristor conducting channel under bias reversal by accumulation and depletion of oxygen in the channel. Oxidation leads to a higher resistance due to sparser conduction centers for the electrons to hop between. Here, we show that they are likely due to neutral oxygen vacancies located at `in-plane' sites of the Ta-O polyhedra.

Goldfarb, Ilan; Williams, R. Stanley

2014-02-01

401

Neutron diffusion in a randomly inhomogeneous multiplying medium with random phase approximation  

NASA Astrophysics Data System (ADS)

Neutron diffusion in a randomly inhomogeneous multiplying medium is studied. By making use of a random phase assumption we show that the average neutron density approximately satisfies an integral equation in Fourier space, which is solved using Kummer functions. We used multi-dimensional formulation. In the case of one dimension, we obtain the result of Rosenbluth and Tao for the mean total density for large t. In the three-dimensional case, a closed form of solution is derived for the mean total neutron density. Its asymptotic behavior is also investigated for large t.

Imre, Kaya; Akcasu, A. Ziya

2012-06-01

402

Urinary cadmium level in children between nine to fifteen years old in three Sub-districts of Tak Province in Thailand  

NASA Astrophysics Data System (ADS)

Urinary cadmium (UCd) is an indicator of the long term exposure of human health. The objective of this research was to study UCd of people aged between 9 to 12 and 13 to 15 years old in both sexes in Prathadpadeang, in Mae Tao and Mae Ku. 849 urines were collected, and determined by using the ICP-MS. The results revealed that 64.30% had UCd less than 1 ?g/gCr. X UCd in 3 Sub-districts were 0.132 ?g/gCr in Prathadpadeang, 0.141 ?g/gCr in Mae Tao, and 0.105 ?g/gCr in Mae Ku. The difference in the 3 Sub-districts was significant. X UCd were 0.125 ?g/gCr and 0.129 ?g/gCr in boys and girls, and 0.119 ?g/gCr and 0.135 ?g/gCr in age group 9-12 and 13-15 years old.

Chaiwong, S.; Sthiannopkao, S.; Kim, K. W.; Chuenchoojit, S.; Poopatpiboon, K.; Poodendean, C.; Supanpaiboon, W.

403

CORRIGENDUM: Prospects for a new boson W+/-1 in the minimal Higgsless model at the LHC Prospects for a new boson W+/-1 in the minimal Higgsless model at the LHC  

NASA Astrophysics Data System (ADS)

The author list originally given in the above article (Ming-Shui Chen, Jian-Guo Bian, Guo-Ming Chen, Hong-Jian He, Chun-Hua Jiang, Zu-Hao Li, Song Liang, Xiang-Wei Meng, Yong-Hui Qi, Zhi-Cheng Tang, Jun-Quan Tao, Zheng Wang, Jian Wang, Jian Wang, Xian-You Wang, Jian-Xiong Wang, Hong Xiao, Min Yang, Jing-Jing Zang, Bin Zhang, Zhen Zhang and Zhen- Xia Zhang) is incorrect. The correct author list is: Ming-Shui Chen, Jian-Guo Bian, Guo-Ming Chen, Chun-Hua Jiang, Zu-Hao Li, Song Liang, Xiang-Wei Meng, Zhi-Cheng Tang, Jun-Quan Tao, Zheng Wang, Jian Wang, Jian Wang, Xian-You Wang, Jian-Xiong Wang, Hong Xiao, Min Yang, Jing-Jing Zang, Bin Zhang, Zhen Zhang and Zhen-Xia Zhang. Hong-Jian He and Yong-Hui Qi did not take part in the writing of this text and do not bear any responsibility for its contents. Also, reference [4] in the paper should be corrected to: [4] Hong-Jian He et al 2008 Phys. Rev. D 78 031701(R)

Chen, Ming-Shui; Bian, Jian-Guo; Chen, Guo-Ming; He, Hong-Jian; Jiang, Chun-Hua; Li, Zu-Hao; Liang, Song; Meng, Xiang-Wei; Qi, Yong-Hui; Tang, Zhi-Cheng; Tao, Jun-Quan; Wang, Zheng; Wang, Jian; Wang, Jian; Wang, Xian-You; Wang, Jian-Xiong; Xiao, Hong; Yang, Min; Zang, Jing-Jing; Zhang, Bin; Zhang, Zhen; Zhang, Zhen-Xia

2009-12-01

404

Variability of the wind field in the tropical oceans as observed by satellite sensors  

NASA Astrophysics Data System (ADS)

The wind stress is the primary force driving the tropical oceans from daily to interannual time scales. Conventional measurements from ships of the wind vectors are not available with a sufficient quality regarding data accuracy as well as their coverage. Satellite observations of the surface wind over the sea are now available on a routine basis at the Institut Francais de Recherche pour l'Exploitation de la Mer (IFREMER), derived from the European Remote Sensing-1 (ERS-1) scatterometer and altimeter and from the radiometer special sensor microwave/imager (SSM/I). More than 3 years of weekly stress fields (1991-1994) with a resolution of one degree in latitude and longitude are produced using an objective analysis method. The accuracy of these gridded winds was evaluated by comparison with TAO buoys in the tropical Pacific area (Riou, 1995). The root mean square differences are of the order of 1.2 m/s and 15 degrees. The greatest differences are observed in the TOGA/COARE region where the wind variability is largest on the weekly scale. The low frequencies (monthly to interannual) of the wind variability are discussed and compared to those obtained from the TAO buoys. In this paper the time and space scales of the sea surface wind are described using a complex EOF analysis. One of the most interesting results is that the weekly averaged wind fields derived from ERS-1 scatterometer are useful to depict a 30-50 day oscillation over the tropical Pacific Ocean.

Grima, N.; Bentamy, A.; Quilfen, Y.

1995-12-01

405

First-principles study of the electronic, optical properties and lattice dynamics of tantalum oxynitride.  

PubMed

First-principles calculations of the electronic, optical properties and lattice dynamics of tantalum oxynitride are performed with the density functional theory plane-wave pseudopotential method. The analysis of the electronic structure shows a covalent nature in Ta-N bonds and Ta-O bonds. The hybridization of anion 2p and Ta 5d states results in enhanced dispersion of the valence band, raising the top of the valence band and leading to the visible-light response in TaON. It has a high dielectric constant, and the anisotropy is displayed obviously in the lower energy region. Our calculation indicated that TaON has excellent dielectric properties along [010] direction. Various optical properties, including the reflectivity, absorption coefficient, refractive index, and the energy-loss spectrum are derived from the complex dielectric function. We also present phonon dispersion relation, zone-center optical mode frequency, density of phonon states, and some thermodynamic properties. The experimental IR modes (B(u) at 808 cm(-1) and A(u) at 863 cm(-1)) are reproduced well and assigned to a combination of stretching and bending vibrations for the Ta-N bond and Ta-O bond. The thermodynamic properties of TaON, such as heat capacity and Debye temperature, which were important parameters for the measurement of crystal physical properties, were first given for reference. Our investigations provide useful information for the potential application of this material. PMID:20583801

Li, Pan; Fan, Weiliu; Li, Yanlu; Sun, Honggang; Cheng, Xiufeng; Zhao, Xian; Jiang, Minhua

2010-08-01

406

Numerical Modelling of the Drainage Evolution of the Ebro Basin (NE Spain)  

NASA Astrophysics Data System (ADS)

The Ebro foreland basin (NE Iberia) initiated its formation during the Palaeocene as a result of the collision and subduction of the Iberian plate underneath the European plate. The basin became landlocked in late Eocene by the Pyrenees, the Catalan Coastal Ranges and the Iberian Range, and was subsequently filled with alluvial, fluvial and lacustrine (sometimes evaporitic) deposits delivered by a large endorheic fluvial network. During the Miocene, the Catalan Coastal Ranges underwent extension and became the rift flank of the Valencia Trough (W Mediterranean). However, the Ebro Basin remained closed at least until late Miocene times, when the endorheic fluvial system opened through the Ebro River to the Mediterranean initiating the formation of the delta. The causes for this major drainage change are not well understood. Although the style of tectonic deformation and the erosion/transport properties of rivers are often invoked to explain changes in drainage patterns, the regional isostatic behaviour of the lithosphere cannot be ignored, since it controls the vertical movements in foreland basins. In this work, we link quantitatively these processes in a 3D numerical model of drainage evolution constrained by well logs, geological cross sections and fission track data. The results suggest that the capture of the endorheic drainage was driven by sediment overfilling of the basin and the erosion of up to 3-4 km of the Catalan Coastal Ranges rift flank, which flexural uplift significantly delayed the drainage opening. >http://www.geo.vu.nl/\\sim$gard/tao/tao3D.html

Garcia-Castellanos, D.; Verges, J.; Gaspar-Escribano, J.; Juez-Larre, J.; Cloetingh, S.

2001-12-01

407

Optical properties and microstructures of inorganic wave plates prepared by serial bideposition  

NASA Astrophysics Data System (ADS)

We investigated the optical characteristics and microstructures of wave plates composed of TaO(100-x)+TiO(x) and prepared by the so-called serial bideposition technique. While a single-layer film prepared by conventional oblique deposition technique has a tilted columnar structure (i.e., tilted optical axis), a serial bideposition film has a narrow, long columnar structure; this ensures that the optical axis of the film is along the quasinormal to the substrate, thus reducing haze. The influence of using additives with TaO was investigated as well. It was found that additive TiO improves optical transmittance at shorter wavelengths. For verifying the advantage of this type of wave plates, quarter wave plates with optimized TiO content were fabricated and their optical performance and reliability were evaluated against those of organic-type wave plates. The results show that the inorganic wave plate prepared by serial bideposition is advantageous for applications where high-transmittance and high-temperature durability are essential.

Koike, Nobuyuki; Sasaki, Koji; Yamada, Takatoshi; Hanashima, Naoki; Takada, Akio; Suzuki, Motofumi

2014-01-01

408

Classification of single particle optical scattering patterns by the spectrum enhancement algorithm  

NASA Astrophysics Data System (ADS)

Airborne material particles in the 5?m size range have been collected, resuspended and analyzed by the TAOS (two-dimensional angular optical scattering) technique. The corresponding patterns of light intensity scattered by single particles have been automatically classified by an algorithm based on "spectrum enhancement", multivariate statistics and supervised optimization. The enhanced spectrum has resulted from some non-linear operations on fractional spatial derivatives of the pattern. It has yielded morphological descriptors of the pattern. A multiobjective optimization algorithm has included principal components analysis and has maximized pairwise discrimination between classes. The classifier has been trained by TAOS patterns from 10?m polystyrene spheres (P) and background aerosol particles (B). Then it has been applied to recognize patterns from airborne debris (A) sampled on a car racing track. Training with at least 10 patterns per class has discriminated P and B from A at confidence levels >=90%. Training by samples of smaller sizes (e.g., 5P and 12B patterns) has obviously yielded lower confidence levels (65% in B-A discrimination).

Crosta, Giovanni F.

2005-11-01

409

The MATHEMATICA economic analysis of the Space Shuttle System  

NASA Technical Reports Server (NTRS)

Detailed economic analysis shows the Thrust Assisted Orbiter Space Shuttle System (TAOS) to be the most economic Space Shuttle configuration among the systems studied. The development of a TAOS Shuttle system is economically justified within a level of space activities between 300 and 360 Shuttle flights in the 1979-1990 period, or about 25 to 30 flights per year, well within the U.S. Space Program including NASA and DoD missions. If the NASA and DoD models are taken at face value (624 flights), the benefits of the Shuttle system are estimated to be $13.9 billion with a standard deviation of plus or minus $1.45 billion in 1970 dollars (at a 10% social rate of discount). If the expected program is modified to 514 flights (in the 1979-1990 period), the estimated benefits of the Shuttle system are $10.2 billion, with a standard deviation of $940 million (at a 10% social rate of discount).

Heiss, K. P.

1973-01-01

410

Synthesis, Structure, and Physical Properties for a Series of Trigonal Bipyramidal MII-Cl Complexes with Intramolecular Hydrogen Bonds  

PubMed Central

A series of transition metal chloro complexes with the tetradentate tripodal tris(2-amino-oxazoline) ligand TAO have been synthesized and characterized. X-ray structural analyses of these compounds demonstrate the formation of the mononuclear complexes [MII(TAO)(Cl)]+, where MII = Cr, Mn, Fe, Co, Ni, Cu and Zn. These complexes exhibit distorted trigonal-bipyramidal geometry, coordinating the metal through an apical tertiary amine, three equatorial imino nitrogen atoms, and an axial chloride anion. All the complexes possess an intramolecular hydrogen-bonding (H-bonding) network within the cavity occupied by the metal-bound chloride ion. The metal-chloride bond distances are atypically long, which is attributed to the effects of the H-bonding network. Nuclear magnetic resonance (NMR) spectroscopy of the Zn complex suggests that the solid-state structures are representative of that observed in solution, and that the H-bonding interactions persist as well. Additionally, density functional theory (DFT) calculations were carried out to probe the electronic structures of the complexes.

Sickerman, Nathaniel S.; Park, Young Jun; Ng, Gary K.-Y.; Bates, Jefferson E.; Hilkert, Mark; Ziller, Joseph W.; Furche, Filipp

2013-01-01

411

Crystal structure analysis of tungsten bronzes ?-SrTa2O6 and ??-SrTa2O6 by synchrotron X-ray and neutron powder diffraction  

NASA Astrophysics Data System (ADS)

Strontium ditantalum oxide SrTa2O6 exists in ?-, ?-, and ?'-polymorphs. Herein the crystal structures of the latter two were studied using synchrotron X-ray and constant-wavelength neutron powder diffraction. While ?'-SrTa2O6 [space group P4/mbm, a=12.47099(1) Å, c=3.898210(5) Å, V=606.271(2) Å3, Z=5] belongs to the regular tetragonal tungsten bronze (TTB) family, it contains locally disordered strontium atoms within the pentagonal channel. ?-SrTa2O6 [space group Pnam, a=12.36603(2) Å, b=12.43467(2) Å, c=7.72403(1) Å, V=1187.705(4) Å3, Z=10] can be described as an orthorhombic modification of the TTB, where the octahedral tilting distortion effectively alleviates the bonding strains around TaO6 and SrO13 polyhedra. For comparison, rynersonite type ?-SrTa2O6 [space group Pnma, a=11.00610(6) Å, b=7.63397(3) Å, c=5.62634(3) Å, V=472.727(5) Å3, and Z=4] is built from edge-shared dimer units of TaO6 octahedra. As measured by diffuse-reflection absorption spectroscopy, ?-, ?-, and ?'-SrTa2O6 have indirect band gap energies of 4.4, 4.0, and 3.8 eV, respectively.

Lee, Eunhye; Park, Cheol-Hee; Shoemaker, Daniel P.; Avdeev, Maxim; Kim, Young-Il

2012-07-01

412

Structural influence on the photoluminescence properties of Eu(3+) doped Gd3MO7 (M = Nb, Sb, and Ta) red phosphors.  

PubMed

New red phosphor materials of general formula Gd3-xMO7:xEu(3+) (M = Nb, Sb, and Ta) were prepared using a high temperature solid state reaction route. Detailed structural studies using XRD, FT-IR and Raman spectroscopic techniques showed that niobate and tantalate samples crystallized in the weberite type structure whereas the antimonate sample in the fluorite structure. Photoluminescence properties of the three compositions are correlated with their crystal structures. It was observed that more ordering occurs in the lattice when an M site is doped from Sb to Nb to Ta. Although niobate and tantalate samples possess similar structures more distortions were noticed in the tantalate sample increasing the radiative transition probabilities. Due to the more ordered structure of the Gd3TaO7 host lattice resulting in a more uniform distribution of Eu(3+) ions, the tantalate system showed better luminescence properties. The variation in the luminescence intensity with various Eu(3+) concentrations in the Gd3TaO7 host lattice was also studied to calculate the optimum doping concentration. PMID:25006862

Francis T, Linda; Prabhakar Rao, P; Thomas, Mariyam; S K, Mahesh; V R, Reshmi; T S, Sreena

2014-08-28

413

(Ln = Pr, Nd, M = Nb, Ta)  

NASA Astrophysics Data System (ADS)

High-pressure X-ray diffraction measurements have demonstrated that the cation-deficient perovskites Pr1/3NbO3, Pr1/3TaO3, Nd1/3NbO3, and Nd1/3TaO3 undergo irreversible pressure-induced amorphization (PIA). This occurs near 14.5 GPa for the niobates and 18.5 GPa for the tantalates. The unit cell volumes of the four oxides show an almost linear decrease as the pressure is increased. It is concluded that the PIA transition occurs at higher pressures in the tantalates due to the lower MO6 initial tilting at ambient conditions, which is associated with the larger atomic mass of the tantalum. The behavior of these oxides is compared to that of CaTiO3, and the role of both the weakening of the M-O-M ?-bonding and the cation vacancies on the observed structural changes is discussed.

Noked, O.; Melchior, A.; Shuker, R.; Steininger, R.; Kennedy, B. J.; Sterer, E.

2014-06-01

414

Enhancement of green-light photoluminescence of Ta2O5 nanoblock stacks.  

PubMed

In this study we have explored the structural, electronic, and photoluminescence (PL) properties of Ta(2)O(5) nanoblock stacks. The Ta(2)O(5) nanoblocks were synthesized by the hot filament metal-oxide vapor deposition (HFMOVD) technique and randomly arranged in large-area stacks. Field-emission scanning electron microscopy (FESEM) showed most of the stacking Ta(2)O(5) nanoblocks to be 21 nm wide. Energy dispersive spectroscopy (EDS) analysis verified the presence of only the elements Ta and O. X-Ray photoemission spectroscopy (XPS) not only revealed the electronic structures and chemical properties of the stacking Ta(2)O(5) nanoblocks but also their stoichiometric Ta/O ratio of ?0.416 (i.e. Ta:O = 2.08?:?5). Photoluminescence (PL) spectroscopy showed very strong green-light emissions, which emerged from the trap-levels of the oxygen vacancies within the Ta(2)O(5) bandgap. The PL intensities were linearly enhanced by increasing the laser power and the excitation time. The PL results suggest that the nanoblocks are excellent visible-light emitters. PMID:21709873

Devan, Rupesh S; Lin, Ching-Ling; Gao, Shun-Yu; Cheng, Chia-Liang; Liou, Yung; Ma, Yuan-Ron

2011-08-01

415

Electronics for the pulsed rubidium clock: design and characterization.  

PubMed

Pulsing the different operation phases of a vapor-cell clock (optical pumping, interrogation, and detection) has been recognized as one of the most effective techniques to reduce light shift and then to improve the stability perspectives of vapor cell clocks. However, in order to take full advantage of the pulsed scheme, a fast-gated electronics is required, the times involved being of the order of milliseconds. In this paper we describe the design and the implementation of the electronics that synchronizes the different phases of the clock operation, as well as of the electronics that is mainly devoted to the thermal stabilization of the clock physics package. We also report some characterization measurements, including a measurement of the clock frequency stability. In particular, in terms of Allan deviation, we measured a frequency stability of 1.2 x 10(-12) tao(-1/2) for averaging times up to tao = 10(5) s, a very interesting result by itself and also for a possible space application of such a clock. PMID:17941380

Calosso, Claudio E; Micalizio, Salvatore; Godone, Aldo; Bertacco, Elio K; Levi, Filippo

2007-09-01

416

Radioiodine I-131 for the therapy of graves' disease.  

PubMed

Graves' disease is a common cause of hyperthyroidism. Treatment options for Graves' disease include antithyroid medication, surgery or radioactive iodine (I-31) or RAI. This review will focus on the approach to RAI therapy; discussing dose selection, patient preparation, and consideration before and after administering RAI, examining aspects of pre-treatment with antithyroid medication as well as discussing possible adverse events including hypothyroidism and possible worsening of thyroid-associated opthalmopathy. Follow-up is lifelong with the aim of ensuring the patient remains euthyroid or on replacement therapy if there is evidence of hypothyroidism. While there are controversies in treatment of thyrotoxicosis with RAI, with appropriate patient selection and regular follow-up, radioiodine is a safe and effective modality in achieving high cure rates. PMID:22589645

Mumtaz, Malik; Lin, Lim Shueh; Hui, Khaw Chong; Mohd Khir, Amir Sharifuddin

2009-01-01

417

Thyroid hormones and tendon: current views and future perspectives. Concise review  

PubMed Central

Summary Thyroid hormones (THs) T3 and T4, play an essential role in the development and metabolism of many tissues and organs, and have profound metabolic effects in adult life. THs action is mediated mainly by the thyroid hormone receptor (TRs) which seem to be ubiquitous. To-date thyroid-associated disease are not thought to be related in tendinopathies and tendons tears. Recent study demonstrated the presence of TRs in tendons and their possible role in the proliferation and apoptosis of human tenocyte isolated from tendon. We review new discovery that revisit our current thinking on the tendon biology focusing on thyroid hormones (THs) T3 and T4, and their possible role on human tenocyte.

Oliva, Francesco; Berardi, Anna C.; Misiti, Silvia; Maffulli, Nicola

2013-01-01

418

A girl with type 1 diabetes and a yellowish appearance.  

PubMed

Type 1 diabetes mellitus in children has been associated with other autoimmune diseases, especially coeliac disease and autoimmune thyroiditis. This association may be the result of a common pathogenic background. We describe the case of a girl with type 1 diabetes mellitus who developed icterus due to autoimmune hepatitis, a disease rarely found in children. Thyroiditis-associated and diabetes-associated autoantibodies were also present. Human leucocyte antigen typing revealed DRB1*03 heterozygosity, which has been associated with the occurrence of both autoimmune hepatitis and type 1 diabetes. This finding implies that similar pathogenic pathways may be involved in different autoimmune diseases including type 1 diabetes and autoimmune hepatitis. The patient was successfully treated with prednisolone and azathioprine. Autoimmune hepatitis can be a serious co-occurring disease in patients with type 1 diabetes. PMID:22797478

Hovinga, I C L Kremer; Stam, E D; Mearin, M L; Mul, D

2010-01-01

419

An Improved Method for TIMS High Precision Nd Isotopic Analysis of Very Small Aliquots (1- 10ng) With Example Application in Garnet Sm/Nd Geochronology  

NASA Astrophysics Data System (ADS)

Technological and scientific developments have demonstrated both the attainability and the utility of very high precision (i.e. 5-20ppm 2 ?) Nd isotopic measurements with TIMS. However such high precision has been limited to relatively large aliquots of Nd, on the order of several hundred nanograms. Several potential applications of precise Nd isotopic measurements, including garnet Sm/Nd geochronology, do not always permit such large samples, instead yielding only a few nanograms of Nd. We have explored and tested an improved method for Nd isotopic analysis of such small (1-10ng) aliquots of Nd using the NdO+ method with a Triton TIMS at Boston University. Analyzing Nd isotopes as the oxide is a well known technique, frequently involving an oxygen bleed valve. Instead, we forego the bleed valve and load samples with a TaO slurry which provides the oxygen source. Using an in-house Nd isotopic standard solution, 4ng loads easily yield stable 2.0-2.5 volt beams resulting in internal precisions of 10ppm 2 ? RSE. Within barrel external precision of 4ng loads of the Nd standard is 13ppm 2 ? RSD (n=20). Long term (6 months, six analysts) external precision of 4ng loads of the standard is currently 23ppm 2 ? RSD (n=55) suggesting that further improvements are possible. As a further test of this method, we dissolved a natural rock sample (a metapelite), separated the Nd using TRU- spec and MLA column chemistry, and loaded nineteen 4ng loads in one barrel. Within barrel external precision was 21ppm 2 ? RSD (n=18). This precision represents a significant advance over previous NdO+ analyses of small samples using an oxygen bleed valve. The TaO loading method for small Nd aliquots is useful in Sm/Nd garnet geochronology as exemplified by two case studies. Garnets from eclogite facies gneisses from Norway ran very well with 2.4-18ng loads and yielded age precision as good as 0.8 million years 2 ?. Conversely, garnets from blueschist facies rocks from Sifnos, Greece, ran poorly with similarly sized 1-17ng loads and consequently yielded generally poorer age precision. Differences between the two garnet sample suites must relate to the garnets themselves (notably including much lower Nd concentration in Sifnos garnets), not the identical column chemistry nor the TaO loading method. Additional procedures may be required to cleanly separate Nd from samples where Nd concentrations are very low (?1ppm). As always, clean separation and column chemistry represents an unavoidable limiting factor in achieving precise isotopic measurements.

Baxter, E. F.; Harvey, J.; Mehl, L. Y.; Peterman, E. M.

2007-12-01

420

Warm Eddy Structure Observed During EPIC in Eastern Pacific Ocean  

NASA Astrophysics Data System (ADS)

During the NSF/NOAA sponsored Eastern Pacific Investigation of Climate (EPIC) field program in Sept. and Oct. 2001, oceanic current, temperature and salinity profiles were acquired by deploying expendable profilers from research aircraft flights above the warm pool grid centered on the TAO mooring at 10oN 95oW and the R/V Ron Brown, and along the 95oW transect from the NOAA WP-3D and the NCAR WC-130, respectively. Analyses of mooring, ship and aircraft observations suggest the propagation of a wind-forced, warm eddy in accord with remotely sensed fields from radar altimetry and TRMM microwave imager (TMI) measurements. This anti- cyclonically rotating warm eddy, consistent with Rossby wave dynamics, impacted both the oceanic and atmospheric mixed layer structure. To examine the evolving characteristics of this oceanic feature, SSTs, isotherm depths and oceanic heat content variations (relative to the 26oC isotherm depth referred to as OHC) were compared at the TAO buoy. Satellite- based OHC variations were estimated by inferring isotherm depths (20oC, 26oC) from blended and objectively mapped, altimeter-derived surface height anomaly (SHA) fields based on climatology and TMI-derived SSTs. Based on sequential maps of the SHA, the observed warm eddy had SHA elevation of 12 to 14 cm that indicated a propagation speed of 13 cm s-1 towards the southwest. Inferred isotherm depths and OHC variations agreed with those from the TAO mooring and profiler measurements. For example, the 26oC isotherm depth ranged from 35 to 40 m with OHC values of 40 kJ cm-2. Understanding the evolving 3-D structure of these features is central to assessing the upper ocean's role in hurricane intensity fluctuations in the Eastern Pacific Ocean. This approach is now being applied to several years of in situ and remotely sensed measurements in this regime to assess uncertainties in satellite retrievals to build climatology for use with hurricane intensity forecast models as in the Atlantic Ocean basin as part of the NOAA Joint Hurricane Testbed program.

Shay, L. K.; Jaimes, B.; Brewster, J.

2007-05-01

421

Mild clinical expression of myasthenia gravis associated with autoimmune thyroid diseases.  

PubMed

Myasthenia gravis (MG) may occur in association with autoimmune thyroid diseases (AITD). The aim of this study was to evaluate the features of MG associated with AITD compared to those of MG without AITD. A total of 129 MG patients (34 men and 95 women; age range, 11-81 yr) were subdivided into: group A, 56 MG patients with AITD [25 with autoimmune thyroiditis and 31 with Graves' disease (GD)]; group B, 21 MG patients with nonautoimmune thyroid diseases; and group C, 52 MG patients without thyroid disease. The severity of MG was ranked according to the Osserman score. Laboratory evaluation included assays for antithyroid and antiacetylcholine receptor (AchRAb) antibodies. Ocular MG (Osserman's class 1) was more frequent in group A (41.0%) than in group B (14.2%; P < 0.03) or C (21.4%; P < 0.03). Severe generalized MG (classes > or = 2B) was more frequent in groups B (57.1%; P < 0.03) and C (51.9%; P < 0.02) than in group A (28.5%). GD patients with clinical evidence of ophthalmopathy had a higher frequency (P = 0.05) of ocular MG (57.8%) than GD patients without clinical ophthalmopathy (16.6%). Thymic disease was less frequent in group A (26.7%) than in group B (71.4%; P = 0.001) or C (59.7%; P = 0.001). The prevalence of thymic hyperplasia was 17.8%, 38.0%, and 40.3% in groups A, B, and C, respectively; the prevalence of thymoma was 8.9%, 33.4%, and 19.4%. When only patients with generalized MG were considered, thymic disease was less frequent (P < 0.02) in group A (40.6%) than in the remaining groups (69.4%). AchRAb was more frequent in groups B (57.1%) and C (57.6%; P < 0.03) than in group A (35.7%). In conclusion, MG associated with AITD has a mild clinical expression, with preferential ocular involvement and lower frequency of thymic disease and AchRAb. This supports the hypothesis that ocular and generalized MG are separate diseases with different spectra of associated diseases. Nonautoimmune thyroid diseases have no influence on the features of MG. The association of ocular MG and AITD might be due to a common autoimmune mechanism and/or a peculiar genetic background. PMID:9024233

Marinó, M; Ricciardi, R; Pinchera, A; Barbesino, G; Manetti, L; Chiovato, L; Braverman, L E; Rossi, B; Muratorio, A; Mariotti, S

1997-02-01

422

Double-hybrid density-functional theory with meta-generalized-gradient approximations  

NASA Astrophysics Data System (ADS)

We extend the previously proposed one-parameter double-hybrid density-functional theory [K. Sharkas, J. Toulouse, and A. Savin, J. Chem. Phys. 134, 064113 (2011)] to meta-generalized-gradient-approximation (meta-GGA) exchange-correlation density functionals. We construct several variants of one-parameter double-hybrid approximations using the Tao-Perdew-Staroverov-Scuseria (TPSS) meta-GGA functional and test them on test sets of atomization energies and reaction barrier heights. The most accurate variant uses the uniform coordinate scaling of the density and of the kinetic energy density in the correlation functional, and improves over both standard Kohn-Sham TPSS and second-order Møller-Plesset calculations.

Souvi, Sidi M. O.; Sharkas, Kamal; Toulouse, Julien

2014-02-01

423

Voids in mixed-cation silicate glasses: Studies by positron annihilation lifetime and Fourier transform infrared spectroscopies.  

PubMed

PALS in comparison with FTIR studies have been applied to investigate the structure of different oxide glasses. Three components of the positron lifetime ? (?1 para- and ?3 ortho-positronium and ?2 intermediate lifetime component) and their intensities were obtained. The results of the calculation of mean values of positron lifetimes for the investigated glasses showed the existence of a long-living component on the positron annihilation lifetime spectra. From the Tao-Eldrup formula we can estimate the size of free volume. On the basis of the measurements we can conclude that the size and fraction of free volume reaches the biggest value for the fused silica glass. The degree of network polymerisation increases void size. PMID:24815814

Reben, M; Golis, E; Filipecki, J; Sitarz, M; Kotynia, K; Jele?, P; Grelowska, I

2014-08-14

424

Complete genome sequence of Nakamurella multipartita type strain (Y-104T)  

PubMed Central

Nakamurella multipartita (Yoshimi et al. 1996) Tao et al. 2004 is the type species of the monospecific genus Nakamurella in the actinobacterial suborder Frankineae. The nonmotile, coccus-shaped strain was isolated from activated sludge acclimated with sugar-containing synthetic wastewater, and is capable of accumulating large amounts of polysaccharides in its cells. Here we describe the features of the organism, together with the complete genome sequence and annotation. This is the first complete genome sequence of a member of the family Nakamurellaceae. The 6,060,298 bp long single replicon genome with its 5415 protein-coding and 56 RNA genes is part of the Genomic Encyclopedia of Bacteria and Archaea project.

Tice, Hope; Mayilraj, Shanmugam; Sims, David; Lapidus, Alla; Nolan, Matt; Lucas, Susan; Glavina Del Rio, Tijana; Copeland, Alex; Cheng, Jan-Fang; Meincke, Linda; Bruce, David; Goodwin, Lynne; Pitluck, Sam; Ivanova, Natalia; Mavromatis, Konstantinos; Ovchinnikova, Galina; Pati, Amrita; Chen, Amy; Palaniappan, Krishna; Land, Miriam; Hauser, Loren; Chang, Yun-Juan; Jeffries, Cynthia D.; Detter, John C.; Brettin, Thomas; Rohde, Manfred; Goker, Markus; Bristow, Jim; Eisen, Jonathan A.; Markowitz, Victor; Hugenholtz, Philip; Kyrpides, Nikos C.; Klenk, Hans-Peter; Chen, Feng

2010-01-01

425

Thermal stability of oxide particles in 12Cr ODS steel  

NASA Astrophysics Data System (ADS)

12Cr ferritic ODS steel was fabricated by mechanical alloying (MA), hot isostatic pressing (HIP) and hot rolling processes. Thermal stability of the oxide particles in the ODS steel sample was evaluated by isothermal annealing at 1250 °C for 500 h. High density YTaO4 particles with a mean size of about 9 nm were observed in the as hipped sample. A significant coarsening of the YTaO4 particles was observed after hot rolling at 1200 °C. Additional coarsening, as well as phase transformation from monoclinic YTaO4 to cubic Y3TaO7 was detected after isothermal annealing at 1250 °C. These results imply that heat treatment temperatures of the ODS steel during fabrication processes should be controlled as low as possible to avoid the undesirable coarsening of oxide precipitates.

Mao, Xiaodong; Kim, Tae Kyu; Kim, Sung Soo; Oh, Kyu Hwan; Jang, Jinsung

2012-09-01

426

Dynamics of Li+ dipoles at very low concentration in quantum paraelectric potassium tantalate  

NASA Astrophysics Data System (ADS)

The dynamics of Li+ dipoles distributed in the quantum paraelectric matrix of potassium tantalate is investigated via linear and nonlinear dielectric response. It is found that the highly diluted solid solution K0.995Li0.005TaO3, KLT(005), reveals nearly ideal Debye-type dipolar relaxation with conventional frequency dispersion at intermediate temperatures, 30Tg~6 K is conjectured.

Dec, J.; Miga, S.; Trybu?a, Z.; Kaszy?ska, K.; Kleemann, W.

2010-05-01

427

Super multiview 3D display system using reflective vibrating scanner array  

NASA Astrophysics Data System (ADS)

In this paper, we present a primitive system design of a super multi-view (SMV) 3-D display system based on a focused light array (FLA) concept using reflective vibrating scanner array (ViSA). The parallel beam scanning using a vibrating scanner array is performed by moving left and right an array of curvature-compensated mirrors or diamond-ruled reflective grating attached to a vibrating membrane. The parallel laser beam scanner array can replace the polygon mirror scanner which has been used in the SMV 3-D display system based on the focused light array (FLA) concept proposed by Kajiki at TAO (Telecommunications Advancement Organization). The proposed system has great advantages in the sense that it requires neither huge imaging optics nor mechanical scanning parts. Some mathematical analyses and fundamental limitations of the proposed system are presented. The proposed vibrating scanner array, after some modifications and refinements, may replace polygon mirror-based scanners in the near future.

Jeon, Ho-In; Jung, Nak-Hee; Choi, Jin-San; Jung, Young; Huh, Young; Kim, Jung-Sam

2001-06-01

428

Morphology and chemical composition analysis of inorganic nanosheets by the field-emission scanning electron microscope system.  

PubMed

Nanosheets can be used as building blocks to fabricate versatile nanostructured materials. In this paper, morphology of the Cs(4)W(11)O(36) and Nb(3)O(8) and TaO(3) sheets with different layers are analyzed by different field-emission scanning electron microscopes (FE-SEMs). Chemical composition of the single-layered Cs(4)W(11)O(36) with thickness of about 2 nm, and multilayered Nb(3)O(8) nanosheets with thickness of less than 14 nm are analyzed by both the Si(Li) solid-state detector and transition edge sensor (TES) microcalorimeter, successfully. The effects of energy resolution, accelerating voltage and substrate on the quantitative analysis are discussed briefly. PMID:19150970

Li, Qinghui; Ono, Yuki; Homma, Yoshikazu; Nakai, Izumi; Fukuda, Katsutoshi; Sasaki, Takayoshi; Tanaka, Keiichi; Nakayama, Satoshi

2009-01-01

429

Parallelism, uniqueness, and large-sample asymptotics for the Dantzig selector  

PubMed Central

The Dantzig selector (Candès and Tao, 2007) is a popular ?1-regularization method for variable selection and estimation in linear regression. We present a very weak geometric condition on the observed predictors which is related to parallelism and, when satisfied, ensures the uniqueness of Dantzig selector estimators. The condition holds with probability 1, if the predictors are drawn from a continuous distribution. We discuss the necessity of this condition for uniqueness and also provide a closely related condition which ensures uniqueness of lasso estimators (Tibshirani, 1996). Large sample asymptotics for the Dantzig selector, i.e. almost sure convergence and the asymptotic distribution, follow directly from our uniqueness results and a continuity argument. The limiting distribution of the Dantzig selector is generally non-normal. Though our asymptotic results require that the number of predictors is fixed (similar to (Knight and Fu, 2000)), our uniqueness results are valid for an arbitrary number of predictors and observations.

Dicker, Lee; Lin, Xihong

2013-01-01

430

The Protective Effect of Cordymin, a Peptide Purified from the Medicinal Mushroom Cordyceps sinensis, on Diabetic Osteopenia in Alloxan-Induced Diabetic Rats.  

PubMed

The aim of this study was to investigate the protective effect of cordymin on diabetic osteopenia in alloxan-induced diabetic rats and the possible mechanisms involved. The diabetic rats received daily intraperitoneal injection with cordymin (20, 50, and 100?mg/kg/day) for 5 weeks. Cordymin could restore the circulating blood glucose, glycosylated hemoglobin (HbA1c), serum alkaline phosphatase (ALP), tartrate resistant acid phosphatase (TRAP), and insulin levels in a dose-dependent manner. Also, the treatment of diabetic rats with cordymin could partially reverse the ? cells death and decrease the total antioxidant status (TAOS) in the diabetic rats. The results may directly and indirectly account for the possible mechanism of the beneficial effect of cordymin on diabetic osteopenia, which was confirmed with the increased bone mineral content (BMC) and bone mineral density (BMD) in diabetic rats (P < 0.05). All those findings indicate that cordymin may play a protective role in diabetic osteoporosis. PMID:24174985

Qi, Wei; Zhang, Yang; Yan, Ya-Bo; Lei, Wei; Wu, Zi-Xiang; Liu, Ning; Liu, Shuai; Shi, Lei; Fan, Yong

2013-01-01

431

The Protective Effect of Cordymin, a Peptide Purified from the Medicinal Mushroom Cordyceps sinensis, on Diabetic Osteopenia in Alloxan-Induced Diabetic Rats  

PubMed Central

The aim of this study was to investigate the protective effect of cordymin on diabetic osteopenia in alloxan-induced diabetic rats and the possible mechanisms involved. The diabetic rats received daily intraperitoneal injection with cordymin (20, 50, and 100?mg/kg/day) for 5 weeks. Cordymin could restore the circulating blood glucose, glycosylated hemoglobin (HbA1c), serum alkaline phosphatase (ALP), tartrate resistant acid phosphatase (TRAP), and insulin levels in a dose-dependent manner. Also, the treatment of diabetic rats with cordymin could partially reverse the ? cells death and decrease the total antioxidant status (TAOS) in the diabetic rats. The results may directly and indirectly account for the possible mechanism of the beneficial effect of cordymin on diabetic osteopenia, which was confirmed with the increased bone mineral content (BMC) and bone mineral density (BMD) in diabetic rats (P < 0.05). All those findings indicate that cordymin may play a protective role in diabetic osteoporosis.

Qi, Wei; Zhang, Yang; Yan, Ya-bo; Lei, Wei; Wu, Zi-xiang; Liu, Ning; Liu, Shuai; Shi, Lei; Fan, Yong

2013-01-01

432

University of Tokyo DIMM: a portable DIMM for site testing at Atacama  

NASA Astrophysics Data System (ADS)

University of Tokyo is now planning to construct a new 6.5m telescope on a peak at Chajnantor region of Atacama, Chile. This project is called "Tokyo Atacama Observatory" (TAO), and site testing is now under progress. As a part of this site testing, we have developed a portable DIMM system which is called a "University of Tokyo DIMM" (UT-DIMM) to measure seeing. The system mostly consists of inexpensive commercial products, which are a MEADE 12 inch telescope, a video-rate CCD camera with an electronic shutter, a Linux based PC, and so on. It has thrifty power consumption and can be operated for one whole night only with a single DC-12V battery for an automobile. In this paper, we describe the instrument, report the current status, and explain its future plans.

Motohara, Kentaro; Doi, Mamoru; Soyano, Takao; Tanaka, Masuo; Kohno, Kotaro; Miyata, Takashi; Takato, Naruhisa; Uraguchi, Fumihiro

2004-07-01

433

Voids in mixed-cation silicate glasses: Studies by positron annihilation lifetime and Fourier transform infrared spectroscopies  

NASA Astrophysics Data System (ADS)

PALS in comparison with FTIR studies have been applied to investigate the structure of different oxide glasses. Three components of the positron lifetime ? (?1 para- and ?3 ortho-positronium and ?2 intermediate lifetime component) and their intensities were obtained. The results of the calculation of mean values of positron lifetimes for the investigated glasses showed the existence of a long-living component on the positron annihilation lifetime spectra. From the Tao-Eldrup formula we can estimate the size of free volume. On the basis of the measurements we can conclude that the size and fraction of free volume reaches the biggest value for the fused silica glass. The degree of network polymerisation increases void size.

Reben, M.; Golis, E.; Filipecki, J.; Sitarz, M.; Kotynia, K.; Jele?, P.; Grelowska, I.

2014-08-01

434

High current, low cost YBCO conductors—what's next?  

NASA Astrophysics Data System (ADS)

The Holy Grail for high temperature superconducting conductors is achieving high current material in a simple and cost-effective way. The current status is encouraging but even after more than twenty years of intense worldwide research, there are still many new avenues to be explored. Innovative functional oxide materials science is central to future progress. This paper discusses three key areas of our research focusing on new directions: highly tailored flux pinning using the new core pinning additives R3TaO7 and RBa2NbO6 for control of nanostructure formation; pinning using magnetic phase additives such as RFeO3 with the potential for a magnetic contribution to the flux pinning; and the use of liquid assisted growth enabling very high growth rates leading to thick films with no critical current degradation.

MacManus-Driscoll, J. L.; Harrington, S. A.; Durrell, J. H.; Ercolano, G.; Wang, H.; Lee, J. H.; Tsai, C. F.; Maiorov, B.; Kursumovic, A.; Wimbush, S. C.

2010-03-01

435

Response of Peach Seedlings to Infection by the Root Lesion Nematode Pratylenchus penetrans under Controlled Conditions.  

PubMed

Twenty-one open pollinated populations of peach rootstock seedlings were evaluated for their response to infection by the root lesion nematode, Pratylenchus penetrans, over a period of 98 days. Nematode-infected peach seedling populations were shorter in plant height and had less shoot weight but more dry root weight than nematode-free controls. Rootstock differences were demonstrated for nematode increase over the 98-day period, and average total numbers of nematodes in soil and roots. Rootstocks were classified into three groups differing in total nematode population levels, ratio of nematode increase, and the number of nematodes per root. The heritable nature of rootstock response to nematodes was evident. Rootstocks showing the lowest response to nematode infection included Tzim Pee Tao, Rutgers Red Leaf, and two progenies of a cross of these two rootstocks. PMID:19294029

Potter, J W; Dirks, V A; Johnson, P W; Olthof, T H; Layne, R E; McDonnell, M M

1984-07-01

436

First International Conference between West and East--Leonardo and Lao-Tze. Western Science Meets Eastern Wisdom. Experiences of Scientists and Intellectuals for the Creation of a New Paradigm of Modern Science  

PubMed Central

The Conference was organized and supported by: Nei Dan School (European School of Internal Martial Arts), NIB (Laboratory of Molecular Biology and Stem Cell Bioengineering, National Institute of Biostructures and Biosystems, Institute of Cardiology, S.Orsola-Malpighi Hospital, Bologna), WACIMA (Worldwide Association Chinese Internal Martial Arts), Arti D’Oriente (Magazine of Eastern culture and traditions), Nuovo Orizzonte (Taiji Quan School in Florence), Samurai (Journal on Martial Arts), and Pinus (First National Institute for the Unification of Medical Strategies). Nei Dan School (www.taichineidan.com, neidan@libero.it) was in charge of the organization. Future meetings of the Centro studi ‘Tao and Science’ will take place in spring 2007 in Firenze and in October 2007 in Bologna. For information: E-mail: neidan@libero.it; web site: www.taichineidan.com, www.taoandscience.com

2008-01-01

437

The role of discursive resources in science talk  

NASA Astrophysics Data System (ADS)

Tao, Oliver, and Venville's paper addresses a debate between two hypotheses of children's development of conceptual understandings of the Earth. The authors aim to investigate whether culture influences students' conceptions of the Earth. However, one questionable assumption shared among conception and conceptual change studies is that researchers can identify children's mental models, through their discourse, to explain their conceptions of scientific phenomena. In this commentary, I challenge this assumption by looking closely at various interview data and examining different dimensions of interview discourse about the Earth. Based on my findings, I suggest that instead of seeing science talk as representations of mental models, we look at children's science talk as discursive practices mediated by the immediate social situation and the broader social milieu.

Hsu, Pei-Ling

2013-06-01

438

InTaO4-based nanostructures synthesized by reactive pulsed laser ablation  

NASA Astrophysics Data System (ADS)

Nanostructured Ni-doped indium-tantalum-oxides (InTaO4) were synthesized by a reactive pulsed laser ablation process, aiming at the final goal of direct splitting of water under visible sunbeam irradiation. The third harmonics beam of a Nd:YAG laser was focused onto a sintered In0.9Ni0.1TaO