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1

Thyroid-Associated Ophthalmopathy and Dermopathy  

Microsoft Academic Search

Graves’ ophthalmopathy [thyroid-associated ophthalmopathy (TAO)] and dermopathy [thyroid-associated dermopathy (TAD)] are\\u000a extrathyroidal manifestations of Graves’ disease, which should be viewed as a multisystem autoimmune disease involving thyrocytes\\u000a but also orbital and pretibial fibroblasts. Smoking is a risk factor for TAO, and cessation of smoking is useful in the primary,\\u000a secondary and tertiary prevention of TAO. The immunopathogenesis of TAO and

Wilmar M. Wiersinga

2

Pathogenesis of thyroid-associated ophthalmopathy: does autoimmunity against calsequestrin and collagen XIII play a role?  

PubMed Central

Thyroid-associated ophthalmopathy (TAO), or thyroid eye disease, is a complex inflammatory disorder of the eye that, as its name implies, is associated with thyroid disease. TAO can be divided into three subtypes: ocular myopathy, congestive myopathy and mixed congestive and myopathic ophthalmopathy. Although the precise pathophysiology of TAO remains unclear it is likely to reflect an autoimmune reaction involving sensitized T-cells and autoantibodies directed against a thyroid and orbital tissue shared antigen. One well studied candidate in this immune reaction is the thyroid-stimulating hormone receptor (TSH-r), expressed in the orbital fibroblast and pre adipocyte. In our studies of TAO, we have investigated the nature and significance of antibodies targeting other eye muscle and orbital connective tissue (OCT) antigens. Our findings suggest that autoimmunity against the eye muscle antigen calsequestrin and the OCT antigen collagen XIII plays a role in the pathogenesis of TAO. We propose that ocular myopathy and chronic eyelid retraction are due to autoimmunity against skeletal muscle calsequestrin in the extraocular and eyelid muscles, respectively. This may be initiated in the thyroid where calsequestrin expression is upregulated, possibly due to a stimulatory effect of TSH-r antibodies. We also propose that congestive ophthalmopathy results from a reaction against the TSH-r or collagen XIII in orbital fibroblast cell membranes. Further insight into the role of eye muscle and OCT antigens in the pathogenesis of TAO may allow for the development of new therapies to treat the eye disorder and reduce patient morbidity.

Lahooti, Hooshang; Parmar, Kishan R; Wall, Jack R

2010-01-01

3

Pathogenesis of thyroid-associated ophthalmopathy: does autoimmunity against calsequestrin and collagen XIII play a role?  

PubMed

Thyroid-associated ophthalmopathy (TAO), or thyroid eye disease, is a complex inflammatory disorder of the eye that, as its name implies, is associated with thyroid disease. TAO can be divided into three subtypes: ocular myopathy, congestive myopathy and mixed congestive and myopathic ophthalmopathy. Although the precise pathophysiology of TAO remains unclear it is likely to reflect an autoimmune reaction involving sensitized T-cells and autoantibodies directed against a thyroid and orbital tissue shared antigen. One well studied candidate in this immune reaction is the thyroid-stimulating hormone receptor (TSH-r), expressed in the orbital fibroblast and pre adipocyte. In our studies of TAO, we have investigated the nature and significance of antibodies targeting other eye muscle and orbital connective tissue (OCT) antigens. Our findings suggest that autoimmunity against the eye muscle antigen calsequestrin and the OCT antigen collagen XIII plays a role in the pathogenesis of TAO. We propose that ocular myopathy and chronic eyelid retraction are due to autoimmunity against skeletal muscle calsequestrin in the extraocular and eyelid muscles, respectively. This may be initiated in the thyroid where calsequestrin expression is upregulated, possibly due to a stimulatory effect of TSH-r antibodies. We also propose that congestive ophthalmopathy results from a reaction against the TSH-r or collagen XIII in orbital fibroblast cell membranes. Further insight into the role of eye muscle and OCT antigens in the pathogenesis of TAO may allow for the development of new therapies to treat the eye disorder and reduce patient morbidity. PMID:20505833

Lahooti, Hooshang; Parmar, Kishan R; Wall, Jack R

2010-05-14

4

CT features of exophthalmos in Chinese subjects with thyroid-associated ophthalmopathy  

PubMed Central

AIM : To investigate computed tomography (CT) features of exophthalmos in Chinese subjects with thyroid-associated ophthalmopathy (TAO). METHODS A total of 605 eyes of 325 patients with exophthalmos due to TAO were classified as grade I (mild exophthalmos) or II (severe exophthalmos) based on orbital CT imaging. The increased orbital volume features, such as changes from extraocular muscles, orbital fat, or both, were analyzed. RESULTS A total of 605 eyes were analyzed, among them 62.98% presented grade I exophthalmos, while 36.02% showed grade II exophthalmos. In grade I, 56.69% showed orbital fat change, and in grade II, 89.29% exhibited extraocular muscle enlargement. CONCLUSION Orbital fat and extraocular muscle enlargement are likely to be observed on CTs of subjects with mild and severe exophthalmos, respectively. Our results suggest that CT findings may guide TAO clinical therapy recommendations and prognosis.

Fang, Zhi-Jia; Zhang, Jenny Y.; He, Wei-Min

2013-01-01

5

Lacrimal gland pleomorphic adenoma masquerading as thyroid-associated ophthalmopathy.  

PubMed

Thyroid-associated ophthalmopathy is the most common cause of proptosis in adult female, especially those with positive thyroid antibody. Sometimes, other diagnoses should be considered. A 45-year-old female presented with progressive right proptosis and mild diplopia for 2 years. One year earlier, she had been diagnosed with thyroid-associated ophthalmopathy because of abnormal thyroid autoantibody. Computed tomography scan showed a 2.4- × 1.9- × 1.6-mm heterogeneous soft-tissue density lying above the left eye. Excisional biopsy of this mass revealed the histopathologic diagnosis of pleomorphic adenoma. This case highlights the need for including other diagnoses such as pleomorphic adenoma in the differential diagnosis of patients with proptosis, diplopia and abnormal thyroid antibody. PMID:23514669

Huang, Shih-Kung; Tsai, Chieh-Chih; Lin, Chin-Hsuan; Kau, Hui-Chuan; Kao, Shu-Ching; Lee, Fenq-Lih

2013-08-01

6

Recent insights into the pathogenesis and management thyroid-associated ophthalmopathy  

PubMed Central

Purpose of review To identify and critique the most recent experimental findings regarding the pathogenesis and therapy of thyroid-associated ophthalmopathy (TAO). Recent findings Much of the recent work in this field has focused on identifying genetic alterations associated with the phenotypes of Graves' disease (GD) and TAO and investigating their functional consequences. Identified candidate genes include CD40, cytotoxic T-lymphocyte antigen-4 (CTLA-4), protein tyrosine phosphatase-22 (PTPN22), HLA-MHC and those associated with the X-chromosome. Efforts to generate a complete rodent model of GD continue with little progress. These uniformly involve the immunization of animals with the thyrotropin receptor (TSHR). Studies conducted in vitro have focused on the actions of cytokines in orbital fibroblasts, the potential role of the insulin-like growth factor-1 receptor and activating antibodies directed against it as a fibroblast and T cell activation pathway. Reports continue to appear examining the potential relationship between the TSHR and orbital adipogenesis. Regarding therapy for TAO, small molecules and antibodies disrupting cytokine pathways and lymphocyte function are currently under examination and have yielded promising albeit preliminary results. Summary TAO remains a vexing medical problem, the pathogenesis of which remains uncertain. A number of obstacles continue to plague major advances, not the least of which is the absence of a robust animal model. A few new insights seem to represent departure from traditional thinking about this disease and may herald important innovation.

Gianoukakis, Andrew G.

2012-01-01

7

Outcomes of Various Surgical Procedures on Acquired Lower Eyelid Epiblepharon in Thyroid Associated Ophthalmopathy  

PubMed Central

Purpose To report the outcomes of acquired lower eyelid epiblepharon after various surgeries in thyroid associated ophthalmopathy (TAO) patients. Methods A retrospective review of the medical records of 53 TAO patients with acquired lower eyelid epiblepharon between October 1999 and June 2011 was performed. Data were collected on demographics, type of lower eyelid epiblepharon, the detailed surgical history such as orbital decompression, retraction repair, or epiblepharon repair and surgical outcomes including follow-up period, recurrence of epiblepharon, and post-operative complications. Results Among the 53 TAO patients with acquired lower eyelid epiblepharon, 25 eyes of 17 patients underwent surgical management; 6 eyes of orbital decompression, 1 eye of orbital decompression followed by retraction repair, 2 eyes of orbital decompression followed by epiblepharon repair, 6 eyes of lower eyelid retraction repair, and 10 eyes of epiblepharon repair. Twenty two lower eyelid epiblepharons (88%) were resolved after final surgical treatment without complication during mean 16.2 months (SD, ±29.9 months) of follow up period; three of 6 epiblepharons that remained after orbital decompression underwent subsequent surgical management of retraction repair or epiblepharon repair, and epiblepharons were well-corrected. Mean amount of lower eyelid retraction was decreased from 1.68 mm (SD, ±1.17 mm) to 0.29 mm (SD, ±0.44 mm) after surgery, regardless of the type of surgery (n = 25, p < 0.000, Wilcoxon signed rank test). Conclusions Acquired lower eyelid epiblepharon of TAO should be managed sequentially according to the general serial order of surgical managements in TAO; orbital decompression, correction of lower eyelid retraction and epiblepharon repair. Acquired lower eyelid epiblepharon was well resolved after surgical management in consecutive order, especially after repair of the lower eyelid retraction with a graft, or lower eyelid epiblepharon repair. Decreased lower eyelid retraction with a resolution of epiblepharon after surgery implied that lower eyelid retraction was associated with lower eyelid epiblepharon.

Park, Sung Wook; Choung, Ho-Kyung; Khwarg, Sang In

2012-01-01

8

Rituximab treatment of patients with severe, corticosteroid-resistant thyroid-associated ophthalmopathy  

PubMed Central

Purpose To study the effectiveness of anti-CD20 (Rituximab, RTX, Rituxan®, Genentech Inc. USA) therapy in patients with severe, corticosteroid (CS)-resistant thyroid-associated ophthalmopathy (TAO). Design Retrospective interventional case series Participants Six consecutive subjects with severe, progressive TAO unresponsive to CS. Methods Electronic medical record review of consecutive patients receiving RTX during the previous 18 months. Responses to therapy were graded using standard clinical assessment and flow-cytometric analysis of peripheral lymphocytes. Main outcome measures Clinical activity score (CAS), proptosis, strabismus, treatment side-effects, and quantification of regulatory T cells. Results Six patients were studied. Systemic CS failed to alter clinical activity in all patients (CAS= 5.3 + 1.0 (mean + standard deviation) before vs 5.5 + 0.8 during therapy for 7.5+ 6.4 months, p=1.0). However following RTX treatment, CAS improved from 5.5 + 0.8 to 1.3 + 0.5 at 2 months post treatment (p<0.03) and remained quiescent in all patients (CAS=0.7 + 0.8; p?0.0001) at 6.2 + 4.5 month follow-up. Vision improved bilaterally in all 4 patients with dysthyroid optic neuropathy (DON). None of the six patients experienced disease relapse following RTX infusion and proptosis remained stable (Hertel measurement = 24 + 3.7mm before and 23.6 + 3.7mm after therapy, p=0.17). The abundance of T regulatory cells, assessed in one patient, increased within one week of RTX and remained elevated at 18 month follow-up. Conclusions In progressive, CS-resistant TAO, rapid and sustained resolution of orbital inflammation and DON followed treatment with RTX.

Chong, Kelvin K.L.; Khanna, Dinesh; Afifiyan, Nikoo F.; Hwang, Catherine J; Lee, Diana K.; Chokron Garneau, Helene; Goldberg, Robert A.; Darwin, Christine H; Smith, Terry J; Douglas, Raymond S.

2009-01-01

9

Insulin-like growth factor 1 promotes the proliferation and adipogenesis of orbital adipose-derived stromal cells in thyroid-associated ophthalmopathy.  

PubMed

Thyroid-associated ophthalmopathy (TAO) is characterised by increased volume of the orbital contents involving adipose tissue, but the factors responsible for stimulation of orbital adipogenesis remain uncertain. Previous studies have shown that insulin-like growth factor 1 (IGF-1) is increased in the orbital fatty connective tissues of patients with TAO. The present study was conducted to investigate the effects of IGF-1 on orbital adipose-derived stromal cells (OADSCs) derived from TAO patients and to identify the signalling mechanisms involved. Our results showed that IGF-1 significantly promoted the cell proliferation and lipid accumulation of TAO OADSCs. The mRNA expression of adipogenic markers (adiponectin, leptin, adipocyte fatty acid binding protein [AP2] and fatty acid synthase [FAS]) was increased in TAO cultures treated with IGF-1. Further research demonstrated that the protein levels of peroxisome proliferator-activated receptor-? (PPAR?) were up-regulated when OADSCs were treated with IGF-1. We also found that the inhibition of either IGF-1 receptor (IGF-1R) or phosphoinositide 3-kinase (PI3K) activity decreased the levels of IGF-1-stimulated mRNA encoding adiponectin, leptin, AP2, and FAS, as well as PPAR? protein levels. Moreover, the expression of phosphorylated Akt (p-Akt) protein in TAO cells was up-regulated by IGF-1, while a specific PI3K inhibitor (LY294002) or an antibody of IGF-1R blocked this effect. These results indicate that IGF-1 is a pro-proliferative and pro-adipogenic factor in TAO OADSCs. IGF-1 enhances the adipogenesis of TAO OADSCs by up-regulation of PPAR? via the activation of the IGF-1R and PI3K pathways, suggesting that the blocking of IGF-1R or inhibition of PI3K signalling might be a potential novel therapeutic approach to TAO. PMID:23219871

Zhao, Pingqian; Deng, Yuan; Gu, Ping; Wang, Yefei; Zhou, Huifang; Hu, Yamin; Chen, Ping; Fan, Xianqun

2012-12-05

10

Palmitate induced secretion of IL-6 and MCP-1 in orbital fibroblasts derived from patients with thyroid-associated ophthalmopathy  

PubMed Central

Purpose Orbital fibroblasts are now recognized as the key effectors in the development of thyroid associated ophthalmopathy (TAO). TAO is clinically apparent in approximately 50% of patients with Graves’ hyperthyroidism. High levels of plasma free fatty acids (FFAs) are frequently seen in patients with hyperthyroidism. Palmitate is one of the most abundant FFAs in plasma and aggravates inflammation by promoting secretion of pro-inflammatory cytokines in various cells. In the present study, we characterized orbital fibroblasts from patients with TAO and then examined the effect of palmitate on the production of pro-inflammatory cytokines and hyaluronic acid (HA) in orbital fibroblasts. Methods Orbital fat explants were obtained from patients with TAO undergoing orbital decompression surgery (n=5). The fibroblasts were characterized by antibodies specific for fibroblast markers and Thy-1 (cluster differentiation 90, CD90) by immunostaining and flow cytometry. We then investigated the capability of orbital fibroblasts to secrete cytokines and HA in response to interleukin (IL)-1? using an enzyme-linked immunosorbent assay (ELISA). The effect of palmitate on cytokine and HA production in orbital fibroblasts was examined at the protein level by ELISA and at the mRNA level by quantitative real time RT–PCR. The level of phosphorylation of mitogen-activated protein kinase (MAPK)s, including p38 MAPK (p38), extracellular signal-regulated kinase (ERK), and c-Jun N-terminal kinase (JNK), was measured by immunoblot analysis. We then examined the role of MAPKs on palmitate-induced cytokine production using specific inhibitors to p38, ERK, and JNK, respectively. Results The orbital fibroblasts from patients with TAO were Thy-1- positive fibroblasts (>90%) with the ability to secrete IL-6, IL-8, monocyte chemotactic protein-1 (MCP-1), and HA in response to IL-1?. Treatment with palmitate induced significant production of IL-6 and MCP-1, but not IL-8 and HA, in orbital fibroblasts. IL-6 and MCP-1 expression by palmitate were differentially regulated by MAPKs. IL-6 expression was mediated by the p38, ERK, JNK pathways, whereas MCP-1 expression was mediated by ERK and JNK, but not by p38, in palmitate-treated orbital fibroblasts. Conclusions We show the possible involvement of palmitate in the promotion of inflammation within orbital tissues. This finding may be helpful for understanding the development of TAO in patients with hyperthyroidism.

Paik, Ji-Sun; Cho, Won-Kyung; Oh, Eun-Hye; Lee, Seong-Beom

2012-01-01

11

Semiautomatic regional segmentation to measure orbital fat volumes in thyroid-associated ophthalmopathy. A validation study.  

PubMed

This study was designed to validate a novel semi-automated segmentation method to measure regional intra-orbital fat tissue volume in Graves' ophthalmopathy. Twenty-four orbits from 12 patients with Graves' ophthalmopathy, 24 orbits from 12 controls, ten orbits from five MRI study simulations and two orbits from a digital model were used. Following manual region of interest definition of the orbital volumes performed by two operators with different levels of expertise, an automated procedure calculated intra-orbital fat tissue volumes (global and regional, with automated definition of four quadrants). In patients with Graves' disease, clinical activity score and degree of exophthalmos were measured and correlated with intra-orbital fat volumes. Operator performance was evaluated and statistical analysis of the measurements was performed. Accurate intra-orbital fat volume measurements were obtained with coefficients of variation below 5%. The mean operator difference in total fat volume measurements was 0.56%. Patients had significantly higher intra-orbital fat volumes than controls (p<0.001 using Student's t test). Fat volumes and clinical score were significantly correlated (p<0.001). The semi-automated method described here can provide accurate, reproducible intra-orbital fat measurements with low inter-operator variation and good correlation with clinical data. PMID:24007725

Comerci, M; Elefante, A; Strianese, D; Senese, R; Bonavolontà, P; Alfano, B; Bonavolontà, B; Brunetti, A

2013-08-27

12

Graves' ophthalmopathy.  

PubMed Central

Ophthalmopathy develops in about 30% of patients who have Graves' disease. The pathogenesis, like that of the hyperthyroidism, is probably autoimmune in nature. The eye manifestations are diverse and include lid lag, soft tissue swelling, proptosis, corneal damage, diplopia, and optic neuropathy. The natural history is benign in 90% of patients, with gradual improvement over time. Therapeutic options include corticosteroid therapy, radiation, and surgical treatment. The last is usually the therapy of choice for severe or disfiguring ophthalmopathy.

Barrie, W E

1993-01-01

13

Childhood Graves' ophthalmopathy: results of a European questionnaire study  

Microsoft Academic Search

Objective: Evaluation of the frequency of Graves' ophthalmopathy (GO) and its management in chil- dren and adolescents up to 18 years old with Graves' hyperthyroidism. Study design: This was a questionnaire study (QS) among members of the European Thyroid Associ- ation and the European Society for Paediatric Endocrinology. Approximately 300 QS were sent to members with electronic addresses and 110

G. E. Krassas; M. Segni; W. M. Wiersinga

2005-01-01

14

Update on advanced imaging options for thyroid-associated orbitopathy  

PubMed Central

Thyroid-associated orbitopathy (TAO) is a diverse spectrum of signs and symptoms that appears to have immunologic and pathologic causative factors as diverse as its clinical presentations. Lymphocytes, hormones, and cytokines affect orbital fibroblasts and other similar cells, which exert their effects on orbital tissues, including the extraocular muscles, orbital fat, and optic nerve. This complicated inflammatory cascade and the myriad of clinical findings that result contributes to the active phase of TAO. The distinction between the active and inactive phases of TAO is an important one, as the proper treatment will depend on the disease phase and degree thereof. Several clinical grading scales and scores have been established to help qualify and quantify the disease severity. Aiding clinical exam and acumen, proper and reproducible imaging of the orbit and ocular adnexa is incredibly important to the management of TAO. Orbital ultrasound, computed tomography, magnetic resonance imaging, and scintigraphy each have unique abilities, including quantifying orbital changes, assessing disease activity, correlating orbital findings with clinical changes, guiding appropriate treatment, and monitoring therapeutic responses. Further, study ease, accessibility, cost, sensitivity, specificity, reproducibility, and risks are all important considerations in picking the right test with which to diagnose and follow TAO. This analysis will provide a review of orbital imaging for TAO, including the mechanism of each imaging technique as well as their rationales, advantages, disadvantages, and utilities.

Rabinowitz, Michael P.; Carrasco, Jacqueline R.

2012-01-01

15

Management of Graves' ophthalmopathy  

Microsoft Academic Search

Management of Graves' ophthalmopathy is preferably done in a multidisciplinary setting. Smoking is associated with worse disease outcome. 131I therapy for hyperthyroidism can also worsen ophthalmopathy, especially if administered during active disease or to patients who smoke or have severe hyperthyroidism, or those with high levels of TSH-receptor-binding inhibitory immunoglobulins. Coadministration of steroids and 131I therapy is recommended for such

Wilmar M Wiersinga

2007-01-01

16

The TAOS Robotic Observatory  

NASA Astrophysics Data System (ADS)

The Taiwanese-American Occultation survey (TAOS) operate four small telescopes in central Taiwan to search for occultations by small (~1 km diameter) Kuiper Belt Objects. The system is fully robotic, requiring human intervention only in the event of hardware failures. However, the status of the system during observations is monitored remotely via smart-phone. A successor survey, the Transneptunian Automated Occultation Survey (TAOS II) is currently being constructed. This next generation survey will be more than one hundred times as sensitive as the earlier survey. In this paper, we summarize the science goals of the surveys, describe the two surveys, and discuss the lessons learned in automating the TAOS observations.

Lehner, Matthew; Wen, C.-Y.; Wang, J.-H.; Marshall, S. L.; Schwamb, M. E.; Zhang, Z.-W.; Bianco, F. B.; Gimmarco, J.; Porrata, R.; Alcock, C.; Axelrod, T.; Byun, Y.-I.; Chen, W. P.; Cook, K. H.; Dave, R.; Kim, D.-W.; King, S.-K.; Lee, T.; Lin, H.-C.; Wang, S.-Y.; Yen, W.-L.; Rice, J. A.; de Pater, I.; Szentgyorgyi, A.; Geary, J.; Norton, T.; Reyes-Ruiz, M.

2011-03-01

17

Teaching in the Tao.  

ERIC Educational Resources Information Center

|This book shares the philosophy that what a teacher learned through the martial arts form, Aikido, allowed him to look beyond aggressive acts without responding aggressively himself, viewing the student behind the angry behavior. The teacher notes that compassion works better than any form of discipline he has ever encountered in education. Tao,…

Christie, Patrick

18

E-rosette formation in Graves' ophthalmopathy  

Microsoft Academic Search

We investigated the lymphocyte characteristics of 77 Graves' disease patients with and without infiltrative ophthalmopathy. Thirteen patients with infiltrative ophthalmopathy without prior antithyroid therapy and 20 euthyroid patients with progressive ophthalmopathy demonstrated decreased percentages of active and total erythrocyte rosette-forming lymphocytes compared to thyrotoxic patients without eye disease and to a control population (p < 0.001). There was no significant

Robert C. Sergott; Norman T. Felberg; Peter J. Savino; John J. Blizzard; Norman J. Schatz

19

Taos: A low cost satellite  

NASA Astrophysics Data System (ADS)

Aerospatiale, under contract to CNES, has studied a new satellite based system with the double mission of mobile tracking and paging. This is called Taos. A constellation of five Taos satellites will allow positioning with an accuracy of 1 km, as well as small message transmission with a maximum time delay of 2 hours. Using a low earth orbit, Taos will have a small power budget, with the attendant gains in dimensions, mass, and eventually cost. The emergence of such class of lightsats has been fostered by the progress of electronics, as well as the new small launchers now being offered. Furthermore, the market is clearly hungry for ever more worldwide data collection. This paper describes the Taos system of satellite and ground segment, for which a primary goal will be a significant reduction of the recurring price. Weighing 152 kg, each satellite will have a power of 270 W.

Jung, P.

20

Hashimoto thyroiditis associated with ataxia telangiectasia.  

PubMed

Ataxia telangiectasia is a rare genetic disease characterized by neurological manifestations, infections, and cancers. In addition to these cardinal features, different autoimmune diseases can be seen in patients with ataxia telangiectasia. Although there were reports of positive autoimmune thyroid antibodies associated with ataxia telangiectasia, to our knowledge, we report the first cases of nodular Hashimoto thyroiditis in two patients with ataxia telangiectasia in the English medical literature. These cases illustrate that despite the rarity of nodular Hashimoto thyroiditis associated with ataxia telangiectasia, physicians should be aware of this possibility. Furthermore, thyroid examination of patient with ataxia telangiectasia is recommended for early diagnosis. PMID:22768667

Patiroglu, Turkan; Gungor, Hatice Eke; Unal, Ekrem; Kurtoglu, Selim; Yikilmaz, Ali; Patiroglu, Tahir

2012-01-01

21

The Tao of Rhetoric: Revelations From The Tao of Steve  

Microsoft Academic Search

Scholars have increasingly noted that classical Taoist (Daoist) thought offers important insights on rhetoric. The present study contributes to the development of a Taoist perspective on rhetorical theory and criticism through an analysis of the film The Tao of Steve. While the film appears to be a simple story of how a good girl saves a bad boy, it is

Steven C. Combs

22

Technology Refresh of NOAA's Tropical Atmosphere Ocean (TAO) Buoy System.  

National Technical Information Service (NTIS)

National Oceanic and Atmospheric Administration's (NOAA) Tropical Atmosphere Ocean (TAO) buoy array has a long history of providing valuable climate data to both the climate and forecast communities. A major concern for a sustained and long-term TAO opera...

C. Teng L. J. Bernard P. A. Lessing

2006-01-01

23

Latest Results from the Taiwanese-American Occultation Survey (TAOS)  

NASA Astrophysics Data System (ADS)

TAOS operates four telescopes at Lulin Observatory in Central Taiwan to search for occultations of distant stars by small Kuiper Belt Objects (KBOs). In this presentation, the TAOS project will be described and the latest results will be presented.

Lehner, M. J.; Zhang, Z.-W.; Wang, J.-H.; Alcock, C.; Axelrod, T.; Bianco, F. B.; Byun, Y.-I.; Chen, W. P.; Coehlo, N. K.; Cook, K. H.; de Pater, I.; Granados, A. P.; Kim, D.-W.; King, S.-K.; Lee, T.; Lissauer, J. J.; Marshall, S. L.; Protopapas, P.; Rice, J. A.; Schwamb, M. E.; Wang, S.-Y.; Wen, C.-Y.

2012-05-01

24

TAOS/LS1 development final report  

SciTech Connect

The Laser Sensor No. 1 (LS1) is a system designed and built by Sandia to detect and report laser illumination of an orbiting satellite. It was launched March 1994 as part of the U.S. Air Force Phillips Laboratory, Technology for Autonomous Operational Survivability (TAOS) satellite program. The engineering details of the system are described in this report. Operation characteristics and results have been reserved for inclusion in a classified Air Force report prepared by the TAOS Program Office of Phillips Laboratory.

Phipps, G.S.; Gentry, S.M.; Falls, J.M.; Claassen, P.J.; Alder, G.J.

1997-12-01

25

Lessons from the Tao for birthing practice.  

PubMed

The metaphysics of the Tao Te Ching, as the basic structure of the universe, is used to examine birthing as creation. Lessons from the Tao regarding cultivating naturalness are drawn upon to provide suggestions for women in preparation for birthing, as well as for the nurses and midwives who attend them. Compatibility of this metaphysical view of birthing with Rogers's and Newman's nursing theories is identified, and the importance of honoring the metaphysical and spiritual aspects of birthing in nursing practice is stressed. PMID:8195571

Overman, B

1994-06-01

26

Granulomatous and lymphocytic thyroiditis associated with a follicular adenoma  

Microsoft Academic Search

A 44-year-old woman came to medical attention with right thyroid lobe enlargement and weight loss. Thyroid scan and ultrasound\\u000a demonstrated a nodule in the right thyroid lobe; a right hemithyroidectomy was performed. Histologic examination documented\\u000a granulomatous and lymphocytic thyroiditis associated with a follicular adenoma. No inflammation was apparent within the adenoma.\\u000a The parallels between granulomatous thyroiditis and lymphocytic thyroiditis, including

Meora Feinmesser; David Murray; Nicholas Colapinto; Sylvia L. Asa

1992-01-01

27

Rituximab therapy in steroid-resistant severe hypothyroid Grave's ophthalmopathy  

PubMed Central

Association of Grave's ophthalmopathy with hyperthyroidism is well known, and it has also been reported in euthyroid or hypothyroid autoimmune thyroiditis, which rarely requires treatment. Here, we report a case of bilaterally symmetrical severe corticosteroid-resistant hypothyroid Grave's ophthalmopathy successfully treated with rituximab.

Pandit, Aditi; Gundgurthi, Abhay; Kharb, Sandeep; Brar, Karninder S.; Garg, M. K.

2013-01-01

28

Update on TAO Moored ORG Array.  

National Technical Information Service (NTIS)

During the Coupled Ocean Atmosphere Response Experiment (COARE) six TAO moorings were equipped with optical rain gauges (ORG's). In late 1993 moorings deployed on the equator at 154E and 157.5E were recovered and not redeployed as they were augmentations ...

H. P. Freitag

1994-01-01

29

3D-MRI rendering of the anatomical structures related to acupuncture points of the Dai mai, Yin qiao mai and Yang qiao mai meridians within the context of the WOMED concept of lateral tension: implications for musculoskeletal disease  

Microsoft Academic Search

BACKGROUND: A conceptual model of lateral muscular tension in patients presenting thyroid associated ophthalmopathy (TAO) has been recently described. Clinical improvement has been achieved by using acupuncture on points belonging to the so-called extraordinary meridians. The aim of this study was to characterize the anatomical structures related to these acupuncture points by means of 3D MRI image rendering relying on

Roy Moncayo; Ansgar Rudisch; Christian Kremser; Helga Moncayo

2007-01-01

30

The Transneptunian Automated Occultation Survey (TAOS II)  

NASA Astrophysics Data System (ADS)

The Transneptunian Automated Occultation Survey (TAOS II) will aim to detect occultations of stars by small ( 1 km diameter) objects in the Solar System and beyond. Such events are very rare (< 10-3 events per star per year) and short in duration ( 200 ms), so many stars must be monitored at a high readout cadence. TAOS II will operate three 1.3 meter telescopes at the Observatorio Astro?omico Nacional at San Pedro Martir in Baja California, Mexico. With a 2.3 square degree field of view and a high speed camera comprising CMOS imagers, the survey will monitor 10,000 stars simultaneously with all three telescopes at a readout cadence of 20 Hz.

Lehner, Matthew J.; Wang, Shiang-Yu; Alcock, Charles A.; Cook, Kem H.; Furesz, Gabor; Geary, John C.; Hiriart, David; Ho, Paul T.; Lee, William; Melsheimer, Frank; Norton, Timothy; Reyes-Ruiz, Mauricio; Richer, Michael; Szentgyorgyi, Andrew; Yen, Wei-Ling; Zhang, Zhi-Wei

2012-09-01

31

The Transneptunian Automated Occultation Survey (TAOS II)  

NASA Astrophysics Data System (ADS)

The Transneptunian Automated Occultation Survey (TAOS II) will aim to detect occultations of stars by small ( 1 km diameter) objects in the Solar System and beyond. Such events are very rare (<0.001 events per star per year) and short in duration ( 200 ms), so many stars must be monitored at a high readout cadence. TAOS II will operate three 1.3 meter telescopes at the Observatorio Astronómico Nacional at San Pedro Mártir in Baja California, México. With a 2.3 square degree field of view and a high speed camera comprising CMOS imagers, the survey will monitor 10,000 stars simultaneously with all three telescopes at a readout cadence of 20 Hz.

Lehner, Matthew J.; Wang, S.; Alcock, C. A.; Cook, K. H.; Furesz, G.; Geary, J. C.; Hiriart, D.; Ho, P. T.; Norton, T.; Reyes-Ruiz, M.; Szentgyorgyi, A.; Yen, W.; Zhang, Z.

2012-10-01

32

Feasibility of Tomotherapy for Graves’ Ophthalmopathy  

Microsoft Academic Search

\\u000a \\u000a Purpose:\\u000a   To compare the dosimetry of tomotherapy and the conventional half-beam technique (HBT) or non-split beam technique (NSBT)\\u000a for target coverage and radiation dose to the lacrimal glands and lens.\\u000a \\u000a \\u000a \\u000a \\u000a \\u000a Patients and Methods:\\u000a   A retrospective review of 7 patients with Graves’ ophthalmopathy who had radiotherapy because of disease progression on high\\u000a steroid dose is reported: 3 patients were treated with

Nam P. Nguyen; Shane P. Krafft; Paul Vos; Vincent Vinh-Hung; Misty Ceizyk; Siyoung Jang; Anand Desai; Dave Abraham; Lars Ewell; Christopher Watchman; Russ Hamilton; Beng-Hoey Jo; Ulf Karlsson; Lexie Smith-Raymond

33

Radiation retinopathy after orbital irradiation for Graves' ophthalmopathy  

SciTech Connect

Recent reports indicate that orbital irradiation for Graves' ophthalmopathy is sometimes beneficial, particularly for dysthyroid optic neuropathy, and is not associated with serious complications. We are aware, however, of four patients who were found to have radiation retinopathy after orbital irradiation for Grave's ophthalmopathy. All four patients have decreased central acuity, and three of the four are legally blind in one or both eyes. Computer reconstruction of the dosimetry, based on computed tomography and beam profiles, shows that errors in dosage calculations and radiotherapy technique probably account for the radiation retinopathy in three of the four patients. Radiotherapy for Graves' ophthalmopathy should be administered only by competent radiotherapists who are experienced in the treatment of this disease. Similar errors in dosage calculations and treatment techniques may account for other reports of radiation retinopathy after reportedly safe dosages.

Kinyoun, J.L.; Kalina, R.E.; Brower, S.A.; Mills, R.P.; Johnson, R.H.

1984-10-01

34

Water resources of Taos County, New Mexico  

USGS Publications Warehouse

In Taos County, ground water generally is unconfined and moves toward the Rio Grande or perennial streams. Water quality is good except in some areas where water has high values of specific conductance and hardness and contains high concentrations of dissolved solids and fluoride. Most wells are completed in alluvial sediments of Quaternary and Tertiary age in the Costilla Plains. A few wells are completed in basalt of the Taos Plateau and in alluvium of stream channels in the Sangre de Cristo Mountains. Depths to water in wells range from less than 1 to 1,080 feet below land surface. Well yields range from 1 to 3,000 gallons per minute. Water levels in wells in Sunshine Valley dropped 5 to 50 feet between 1955 and 1970. Ground-water irrigation has since declined and water levels have risen. Surface-water records show the county is a net producer of water. The average discharge gained in the Rio Grande as it flows through the county was 271,700 acre-feet per year for water years 1931-89. The highest mean monthly discharge occurs in May or June due to snowmelt runoff. Water quality ranges from good in upstream reaches to fair in lower reaches. Surface water was the source for 93 percent of water withdrawn in 1990, but ground water was used for all public supply, domestic, and industrial purposes. The largest water use is irrigation. About 28,500 acres were irrigated in 1990; alfalfa, native pasture, and planted pasture accounted for 91 percent of this acreage.

Garrabraut, L. A.

1993-01-01

35

TAOS: An Occultation Survey of the Outer Solar System  

NASA Astrophysics Data System (ADS)

The Taiwanese-American Occultation survey (TAOS) operate four small telescopes in central Taiwan to search for occultations by small (?1 km diameter) Kuiper Belt Objects. The system is fully robotic, requiring human intervention only in the event of hardware failures. However, the status of the system during observations is monitored remotely via smart-phone. A successor survey, the Transneptunian Automated Occultation Survey (TAOS II)1 is currently being constructed. This next generation survey will be more than one hundred times as sensitive as the earlier survey. In my talk I will present the results of TAOS I, discuss the future plans of the survey, and provide a detailed description of the TAOS II project.

Lehner, M. J.; Alcock, C.; Axelrod, T.; Bianco, F. B.; Byun, Y.-I.; Chen, W. P.; Cook, K. H.; de Pater, I.; Geary, J. C.; Kim, D.-W.; King, S.-K.; Lee, T.; Marshall, S. L.; Norton, T.; Protopapas, P.; Rice, J. A.; Ruiz Reyes, M.; Schwamb, M. E.; Szentgyorgyi, A.; Wang, J.-H.; Wang, S.-Y.; Wen, C.-Y.; Zhang, Z.-W.

2011-10-01

36

Trajectory analysis and optimization system (TAOS) user`s manual  

SciTech Connect

The Trajectory Analysis and Optimization System (TAOS) is software that simulates point--mass trajectories for multiple vehicles. It expands upon the capabilities of the Trajectory Simulation and Analysis program (TAP) developed previously at Sandia National Laboratories. TAOS is designed to be a comprehensive analysis tool capable of analyzing nearly any type of three degree-of-freedom, point-mass trajectory. Trajectories are broken into segments, and within each segment, guidance rules provided by the user control how the trajectory is computed. Parametric optimization provides a powerful method for satisfying mission-planning constraints. Althrough TAOS is not interactive, its input and output files have been designed for ease of use. When compared to TAP, the capability to analyze trajectories for more than one vehicle is the primary enhancement, although numerous other small improvements have been made. This report documents the methods used in TAOS as well as the input and output file formats.

Salguero, D.E.

1995-12-01

37

Graves' ophthalmopathy: a review of immunogenetics.  

PubMed

Graves' disease (GD) is the most common cause of thyrotoxicosis and often involves the orbits. Graves' ophthalmopathy (GO), also known as Thyroid Eye Disease (TED), can be clinically significant and advance to sight-threatening stages. Our knowledge of the immunogenetic pathophysiology of GO is rapidly expanding. The present review is an attempt to summarize the current state of knowledge on the immunogenetics of GO. First we briefly review the epidemiology and clinical importance of GO, and then we describe in detail the macromolecular pathogenesis and finally immunogenetics of GO. Discrepancies between the results from various reports and the limitations of the available data are discussed. In particular, there is a scarcity of data from non-Asian populations. While several studies have demonstrated significant associations between polymorphisms in certain genes (especially CTLA-4, HLA-DRB-1, and TNF-?), there is a need for studies that investigate the relationship between polymorphisms and both serum and local concentrations of the resulting proteins. A complete understanding of GO susceptibility and pathogenesis has not been yet possible due to a number of important knowledge gaps that need to be filled by future research. PMID:22654556

Khalilzadeh, Omid; Noshad, Sina; Rashidi, Armin; Amirzargar, Aliakbar

2011-12-01

38

Prognostic factors in the radiotherapy of Graves' ophthalmopathy  

Microsoft Academic Search

Between April 1968 and February 1988, 311 patients with symptomatic and progressive Graves' ophthalmopathy were treated with megavoltage orbital radiotherapy. The patients were divided into three groups: I treated with 20 Gy\\/2 weeks; II treated with 30 Gy\\/3 weeks, and III received 20 Gy\\/2 weeks. The degree of eye involvement was evaluated numerically before and after therapy for each of

Ivy A Petersen; Joseph P Kriss; I. Ross McDougall; Sarah S Donaldson

1990-01-01

39

77 FR 38375 - Notice of Availability of the Final Environmental Impact Statement (FEIS) for the Taos Regional...  

Federal Register 2010, 2011, 2012, 2013

...the Taos Regional Airport Layout Plan Improvements, Taos...new runway and associated facilities and improvements at the Taos...proposed new runway and related facilities and improvements at SKX...and 100 feet wide. Related facilities and improvements...

2012-06-27

40

Treatment of Graves' disease and the course of ophthalmopathy  

SciTech Connect

Contradictory results have been obtained with regards to the effect of various treatment modes on the exacerbation of Graves' ophthalmopathy, probably because the number of patients in each study was small and some studies were analyzed only in relation to one type of treatment. To circument these problems, we studied the course of Graves' ophthalmopathy after various modes of therapy for thyrotoxicosis among 537 patients with Graves' disease. A total of 537 patients with Graves' disease were prospectively studied over an 11-year period. Thirty-one patients were lost to follow-up during the first six months after treatment and were excluded from the study. Of those remaining, 426 received one form of treatment, 79 received two kinds of therapy, and one received three kinds of therapy. Thus, surgical treatments numbered 164, radioactive iodine-131 (/sup 13/1I) treatments numbered 241, and medical treatments numbered 182. Ocular signs were considered improved or exacerbated by the following criteria: decrement or increment of the exophthalmos of 2 mm or more, improvement or deterioration of visual acuity, and regression or progression of extraocular muscle involvement causing diplopia. Among patients who did not have infiltrative ophthalmopathy before treatment, there was no difference in the occurrence of posttreatment exophthalmos in the surgically, medically, and 131I-treated patients (7.1%, 6.7%, and 4.9%, respectively). The incidence and the degree of progression of ophthalmopathy in patients who already had exophthalmos before treatment were similar in the medically, surgically, and 131I-treated groups (19.2%, 19.8%, and 22.7%, respectively). Most of the progression occurred in the posttreatment euthyroid stage. The incidence of improvement of ophthalmopathy was also similar 14.1%, 12.6%, and 12.3% in the medically, surgically, and 131I-treated patients.

Sridama, V.; DeGroot, L.J.

1989-07-01

41

Tao controls epithelial morphogenesis by promoting Fasciclin 2 endocytosis  

PubMed Central

Regulation of epithelial cell shape, for example, changes in relative sizes of apical, basal, and lateral membranes, is a key mechanism driving morphogenesis. However, it is unclear how epithelial cells control the size of their membranes. In the epithelium of the Drosophila melanogaster ovary, cuboidal precursor cells transform into a squamous epithelium through a process that involves lateral membrane shortening coupled to apical membrane extension. In this paper, we report a mutation in the gene Tao, which resulted in the loss of this cuboidal to squamous transition. We show that the inability of Tao mutant cells to shorten their membranes was caused by the accumulation of the cell adhesion molecule Fasciclin 2, the Drosophila N-CAM (neural cell adhesion molecule) homologue. Fasciclin 2 accumulation at the lateral membrane of Tao mutant cells prevented membrane shrinking and thereby inhibited morphogenesis. In wild-type cells, Tao initiated morphogenesis by promoting Fasciclin 2 endocytosis at the lateral membrane. Thus, we identify here a mechanism controlling the morphogenesis of a squamous epithelium.

Gomez, Juan Manuel; Wang, Ying

2012-01-01

42

Discrimination of airborne material particles from light scattering (TAOS) patterns  

NASA Astrophysics Data System (ADS)

Two-dimensional angle-resolved optical scattering (TAOS) is an experimental method which collects the intensity pattern of monochromatic light scattered by a single, micron-sized airborne particle. In general, the interpretation of these patterns and the retrieval of the particle refractive index, shape or size alone, are difficult problems. The solution proposed herewith relies on a learning machine (LM): rather than identifying airborne particles from their scattering patterns, TAOS patterns themselves are classified. The LM consists of two interacting modules: a feature extraction module and a linear classifier. Feature extraction relies on spectrum enhancement, which includes the discrete cosine Fourier transform and non-linear operations. Linear classification relies on multivariate statistical analysis. Interaction enables supervised training of the LM. The application described in this article aims at discriminating the TAOS patterns of single bacterial spores (Bacillus subtilis) from patterns of atmospheric aerosol and diesel soot particles. The latter are known to interfere with the detection of bacterial spores. Classification has been applied to a data set with more than 3000 TAOS patterns from various materials. Some classification experiments are described, where the size of training sets has been varied as well as many other parameters which control the classifier. By assuming all training and recognition patterns to come from the respective reference materials only, the most satisfactory classification result corresponds to ? 20% false negatives from Bacillus subtilis particles and <= 11% false positives from environmental and diesel particles.

Crosta, Giovanni F.; Pan, Yong-Le; Videen, Gorden; Aptowicz, Kevin B.; Chang, Richard K.

2013-05-01

43

TAO Shipboard CTD Program under the National Data Buoy Center.  

National Technical Information Service (NTIS)

Since its modest beginnings in the early 1980s, the Tropical Oceans- Atmosphere (TAO) Program in the equatorial Pacific has evolved into what has been called the 'crown jewel' of the Global Climate Observation System. Along with data from the 55 surface m...

J. D. Boyd L. LeBlanc R. L. Crout

2010-01-01

44

53. Photocopy of the original conception of Tao House drawn ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

53. Photocopy of the original conception of Tao House drawn by architect Frederick L. Confer and inscribed by Mrs. O'Neill to the builder, Lloyd C. Simpson. Dated 1937. - Eugene O'Neill House, Kuss Road, Danville, Contra Costa County, CA

45

TAOS Orbit Determination Results lJsing Global Positioning Satellites  

Microsoft Academic Search

Orbit determination results for the Air Force Phillips Laboratory's Technology for Autonomous Operational Survivability (TAOS) satellite using a Rockwell AST V Global Positioning System (GPS) receiver are presented in this paper. Under a cooperative effort, GPS orbit determination technology developed at Jet Propulsion Laboratory (JPL) has been transferred to the U.S. Air Force. JPL's post processing differential GPS software MIRAGE

Joseph R; Bobby G. Williams; Peter J. Wolff

46

Long-term follow-up of seven patients with ophthalmopathy not associated with thyroid autoimmunity: heterogeneity of autoimmune ophthalmopathy  

PubMed Central

Background Ophthalmopathy is the most common extrathyroidal manifestation of Graves’ disease. However, in approximately 5% of cases this autoimmune eye disorder occurs in the apparent absence of Graves’ hyperthyroidism: the so-called euthyroid Graves’ disease (EGD). Methods Seven patients with EGD were followed for evidence of thyroid and orbital autoimmunity, for up to 10 years. Calsequestrin and collagen XIII antibodies were measured by enzyme linked immunosorbent assay (ELISA), and TSH-receptor (TSH-r) antibodies were measured as TSH-r-binding antibody (TRAb) and thyroid-stimulating immunoglobulin (TSI). Eye signs were characterized and quantified as clinical activity score (CAS), NOSPECS classes, Nunery types 1 and 2, and margin-reflex distance (MRD). Results Calsequestrin antibodies were detected on at least one occasion in three of the seven patients and collagen XIII antibodies were detected one or more times in five patients. In one patient with isolated congestive ophthalmopathy who was studied intensely, collagen XIII antibodies were initially positive and then became negative as the eye disease stabilized, while antibodies targeting calsequestrin were always negative. TRAb was not detected in any patient, but TSI was detected in three patients on one occasion each. Ultrasound abnormalities were found in four of the six patients for whom this was carried out, but there was no clear evidence for thyroiditis in any of these patients. For comparison, 13 patients were studied with typical Graves’ ophthalmopathy. There were no significant differences compared to EGD in respect to the prevalence of positive calsequestrin or collagen XIII antibodies, but these patients included more smokers (eight out of 13 versus none out of seven). Conclusions Earlier studies suggesting that patients with EGD eventually develop thyroid dysfunction have not been confirmed here, although follow-up continues, and the possibility that such patients have had thyroid autoimmunity in the past, or that they will develop it in the future cannot be excluded. Overall, it is likely that the ophthalmopathy associated with Graves’ hyperthyroidism is the same disease as that observed in patients – such as those reported here – in whom thyroid dysfunction and thyroid autoimmunity are not present during the period of follow- up. The role of autoimmunity against the TSH-r in euthyroid patients with ophthalmopathy has not been proven and the significance of the orbital antibodies is unclear.

McCorquodale, Tom; Lahooti, Hooshang; Gopinath, Bamini; Wall, Jack R

2012-01-01

47

Status of the Transneptunian Automated Occultation Survey (TAOS II)  

NASA Astrophysics Data System (ADS)

The Transneptunian Automated Occultation Survey (TAOS II) will aim to detect occultations of stars by small 1 km diameter) objects in the Transneptunian region and beyond. Such events are very rare (< 10-3 events per star per year) and short in duration (˜200 ms), so many stars must be monitored at a high readout cadence. TAOS II will operate three 1.3 meter telescopes at the Observatorio Astronómico Nacional at San Pedro Mártir in Baja California, México. With a 2.3 square degree field of view and high speed cameras comprising CMOS imagers, the survey will monitor 10,000 stars simultaneously with all three telescopes at a readout cadence of 20 Hz. In this presentation, we will describe the project in detail and discuss the progress on the development of the survey infrastructure.

Lehner, Matthew; Wang, S.; Ho, P.; Zhang, Z.; Cook, K.; Yen, W.; Reyes-Ruiz, M.; Hiriart, D.; Richer, M.; Alcock, C.; Szentgyorgyi, A.; Geary, J.; Norton, T.; Furesz, G.

2013-10-01

48

Orbital pseudotumor: a differential diagnosis of Graves' ophthalmopathy.  

PubMed

The objective of this study is to report and discuss a rare and inflammatory cause of exophthalmos. This report describes a patient with exophthalmos, who was initially diagnosed with euthyroid Graves' with good response to therapy. After 8 years of follow-up, she had recurrence of symptoms and a new evaluation revealed the final diagnosis of orbital pseudotumor. Orbital pseudotumor is an uncommon disorder that both radiologically and clinically mimics a malignant process or other inflammatory disease, such as Graves' ophthalmopathy. PMID:21468526

Caminha, Luciana Souza Cruz; Pinto, Elisa Rebelo; Sousa, Priscila Alves Medeiros de; Oliveira, Ricardo Andrade; Conceiçao, Flavia Lucia; Vaisman, Mario

2011-02-01

49

First Results From The Taiwanese-American Occultation Survey (TAOS)  

SciTech Connect

Results from the first two years of data from the Taiwanese-American Occultation Survey (TAOS) are presented. Stars have been monitored photometrically at 4 Hz or 5 Hz to search for occultations by small ({approx}3 km) Kuiper Belt Objects (KBOs). No statistically significant events were found, allowing us to present an upper bound to the size distribution of KBOs with diameters 0.5 km < D < 28 km.

Zhang, Z; Bianco, F B; Lehner, M J; Coehlo, N K; Wang, J; Mondal, S; Alcock, C; Axelrod, T; Byun, Y; Chen, W P; Cook, K H; Dave, R; de Pater, I; Porrata, R; Kim, D; King, S; Lee, T; Lin, H; Lissauer, J J; Marshall, S L; Protopapas, P; Rice, J A; Schwamb, M E; Wang, S; Wen, C

2008-08-22

50

Amaurosis and optic disc blanching during upgaze in graves ophthalmopathy.  

PubMed

A 60-year-old man with worsening Graves ophthalmopathy complained of complete loss of vision in the left eye on upgaze ("gaze-evoked amaurosis" [GEA]). Examination disclosed congestive orbital signs bilaterally. Upon upgaze, intraocular rose from 18 to 35 mm Hg in the left eye and visual acuity fell in that eye from 20/25 to no light perception. Evidence of optic nerve dysfunction and a swollen optic disc were present in the affected eye, and CT showed enlarged extraocular muscles with apical orbital compression of the optic nerve. Fundus photography performed during GEA disclosed blanching of the optic disc surface vessels in the affected eye. Surgical orbital decompression alleviated the congestive features and optic neuropathy and eliminated the GEA. This is the second case of GEA to be reported in Graves ophthalmopathy and the first to document blanching of optic disc vessels. The presumed mechanism of GEA in this patient is optic nerve ischemia, perhaps provoked by an elevation in intraocular pressure in a congested optic disc. PMID:19726945

Seery, Loren S; Zaldívar, Renzo A; Garrity, James A

2009-09-01

51

Concomitant euthyroid Graves' ophthalmopathy and isolated ocular myasthenia gravis.  

PubMed Central

A 44 year old diabetic woman presented with diplopia and bilateral ptosis and mild exophthalmos. The patient was clinically euthyroid, the baseline thyroid function tests were normal, but the thyroid stimulating hormone response to thyrotrophin releasing hormone was flat. Computed tomographic scan and magnetic resonance imaging of the orbits showed left medial and inferior rectus muscle thickening, more prominent on the left side, consistent with Graves' disease. The tensilon stimulation test resulted in resolution of the ptosis and partial improvement of the ophthalmoplegia. The single fibre electromyography was consistent with a defect in neuromuscular transmission. However, forced duction test was normal and anti-acetylcholine receptor antibodies were undetectable. Significant improvement of the extraocular muscle function and resolution of the right ptosis had resulted from anticholinesterase therapy. These findings and the clinical response to therapy were consistent with concomitant euthyroid Graves' ophthalmopathy and ocular myasthenia gravis. Coexistent isolated ocular myasthenia gravis and Graves' ophthalmopathy is rare and should be considered in patients with findings of ocular myasthenia and extraocular muscle dysfunction. Images Figure 1

Raef, H.; Ladinsky, M.; Arem, R.

1990-01-01

52

Glucocorticoid-Induced Disappearance of Long-Acting Thyroid Stimulator in the Ophthalmopathy of Graves' Disease.  

National Technical Information Service (NTIS)

The effect of glucocorticoid therapy on serum longacting thyroid stimulator (LATS) was studied in 3 subjects. In a patient with severe ophthalmopathy and pretibial myxedema, prednisone treatment induced a clinical remission and disappearance of an initial...

N. J. Snyder D. E. Green D. H. Solomon

1964-01-01

53

Mosaic Access to Real-Time Data from the TOGA-TAO Array of Moored Buoys  

Microsoft Academic Search

The TAO Array is a major component of the global climate monitoring system, consisting of approximately 70 moored buoys, spanning the Equatorial Pacific Ocean from 95W in the eastern Pacific to 137E in the west, and telemetering atmospheric and oceanographic data in real time to shore-based computers via the NOAA Argos satellite system. The TAO array allows, for the first

N. N. Soreide; L. C. Mccarty; D. C. Mcclurg

1995-01-01

54

Moral values and the Taoist sage in the Tao de Ching  

Microsoft Academic Search

The theme of this paper is that while there are four seemingly contradictory classes of statements in the Tao de Ching regarding moral values and the Taoist sage, these statements can be interpreted to be consistent with each other. There are statements which seemingly state or imply that nothing at all can be said about the Tao; there are statements

Robert E. Allinson

1994-01-01

55

Update on the medical treatment of Graves' ophthalmopathy  

PubMed Central

Purpose: To review recent advances in the understanding of Graves’ ophthalmopathy (GO) pathogenesis as well as discuss current and future medical management strategies. Design: Interpretive essay. Methods: Literature review and interpretation. Results: Medical treatment of GO has slowly evolved during the past few decades and has been hampered by a poor understanding of the disease at a cellular and molecular level. Current treatment recommendations and guidelines therefore focus on nonspecific immuno-suppression. Newer classes of treatment agents hold promise to more selectively target underlying cellular and molecular alterations in GO. Conclusion: Cooperation between individual patients, physicians and between differing medical centers, together with a refined understanding of the pathogenesis of GO, will lead to newer more-effective treatments for the disease and improve patient quality of life.

Griepentrog, Gregory J; Garrity, James A

2009-01-01

56

The association of carotid cavernous fistula with Graves' ophthalmopathy  

PubMed Central

Graves’ ophthalmopathy (GO) is one of the frequent manifestations of the disorder which is an inflammatory process due to fibroblast infiltration, fibroblast proliferation and accumulation of glycosaminoglycans. Eye irritation, dryness, excessive tearing, visual blurring, diplopia, pain, visual loss, retroorbital discomfort are the symptoms and they can mimic carotid cavernous fistulas. Carotid cavernous fistulas are abnormal communications between the carotid arterial system and the cavernous sinus. The clinical manifestations of GO can mimic the signs of carotid cavernous fistulas. Carotid cavernous fistulas should be considered in the differential diagnosis of the GO patients especially who are not responding to the standard treatment and when there is a unilateral or asymmetric eye involvement. Here we report the second case report with concurrent occurrence of GO and carotid cavernous fistula in the literature.

Celik, Ozlem; Buyuktas, Deram; Islak, Civan; Sarici, A Murat; Gundogdu, A Sadi

2013-01-01

57

Electronic spectrum of TaO and its hyperfine structure.  

PubMed

The B (2)Phi(5/2)-X(1) (2)Delta(3/2)(0,0) band at 778 nm and the C (2)Delta(3/2)-X(1) (2)Delta(3/2)(0,0) band at 737 nm of tantalum oxide (TaO) were recorded by laser excitation spectroscopy using a hollow cathode sputtering source to generate the molecules. The hyperfine structure arising from the (181)Ta (I=72) nucleus was measured at sub-Doppler resolution using the technique of intermodulated fluorescence spectroscopy. The hyperfine structure was assigned and fitted in order to derive accurate values for the magnetic dipole and electric quadrupole interactions. The magnetic hyperfine constant for the ground electronic state was also calculated using the density functional theory as h(3/2)=625 MHz, in good agreement with the experimental value of 647+/-10 MHz. This result suggests that the X (2)Delta ground state of TaO is well described by a pure deltasigma(2) electronic configuration, where the unpaired electron is located in a Ta 5ddelta orbital. PMID:18345883

Manke, Kara J; Vervoort, Tyson R; Kuwata, Keith T; Varberg, Thomas D

2008-03-14

58

Therapeutic Outcome of Prednisone Medication and of Orbital Irradiation in Patients with Graves’ Ophthalmopathy  

Microsoft Academic Search

Response to treatment was evaluated prospectively in 58 patients with Graves’ ophthalmopathy. Prednisone, administered to 44 patients, resulted in a favourable response in 29 patients (66%): excellent in 3, good in 10 and fair in 16 subjects; 15 patients (34%) did not respond. Orbital irradiation was administered to 39 patients of whom all except 4 had been treated previously with

W. M. Wiersinga; T. Smit; A. L. J. Schuster-Uittenhoeve; R. van der Gaag; L. Koornneef

1988-01-01

59

Magnetotelluric data, Taos Plateau Volcanic Field, New Mexico  

USGS Publications Warehouse

The population of the San Luis Basin region of northern New Mexico is growing. Water shortfalls could have serious consequences. Future growth and land management in the region depend on accurate assessment and protection of the region's groundwater resources. An important issue in managing the groundwater resources is a better understanding of the hydrogeology of the Santa Fe Group and the nature of the sedimentary deposits that fill the Rio Grande rift, which contain the principal groundwater aquifers. The shallow unconfined aquifer and the deeper confined Santa Fe Group aquifer in the San Luis Basin are the main sources of municipal water for the region. The U.S. Geological Survey (USGS) is conducting a series of multidisciplinary studies of the San Luis Basin. Detailed geologic mapping, high-resolution airborne magnetic surveys, gravity surveys, an electromagnetic survey called magnetotellurics (MT), and hydrologic and lithologic data are being used to better understand the aquifers. This report describes a regional east-west MT sounding profile acquired in late July 2009 across the Taos Plateau Volcanic Field where drillhole data are sparse. Resistivity modeling of the MT data can be used to help map changes in electrical resistivity with depths that are related to differences in rock types. These various rock types help control the properties of aquifers. The purpose of this report is to release the MT sounding data collected along the east-west profile. No interpretation of the data is included.

Ailes, Chad E.; Rodriguez, Brian D.

2010-01-01

60

Radiotherapy in the treatment of Graves ophthalmopathy—to do it or not?  

Microsoft Academic Search

To the objective of this study is to evaluate the role and toxicity of radiotherapy in the treatment of Graves ophthalmopathy.\\u000a In the years 2000–2003, 121 patients with malignant exophthalmos were treated with radiotherapy of the retrobulbar area to\\u000a the total dose of 20 Gy in ten fractions with a 6 MeV photon beam. The treatment was performed by the team of

Aneta Zygulska

2010-01-01

61

Long-term effects of Graves' ophthalmopathy on health-related quality of life  

Microsoft Academic Search

Objective: Little is known about the long-term effects of Graves' ophthalmopathy (GO) on health- related quality of life (HRQL) after the eye treatment is considered to be finished. The aim of this study was to quantify these effects using validated HRQL questionnaires. Design: A cross-sectional follow-up study was carried out in GO patients who had started radiotherapy and\\/or prednisone treatment

Caroline Terwee; I. M. M. J. Wakelkamp; H. S. Tan; Friedo Dekker; Mark F Prummel; Wilmar Wiersinga

2002-01-01

62

Randomized double-blind trial of prednisone versus radiotherapy in Graves' ophthalmopathy  

SciTech Connect

Corticosteriods are usually given for management of Graves' ophthalmopathy, but they have many and serious side-effects. By comparison, retrobulbar irradiation is well tolerated, although its efficacy has been evaluated only in uncontrolled studies. Therefore, the authors did a double-blind randomized trial, in which 28 patients with moderately severe Graves' ophthalmopathy were treated with a 3-month course of oral prednisone and sham irradiation, and 28 received retrobulbar irradiation (20 Gy) and placebo capsules. Therapeutic outcome, assessed twenty-four weeks after the start of treatment, was determined by the change in the highest NOSPECS class. A successful outcome was observed in 14 prednisone-treated and in 13 irradiated patients. Responders to treatment (but not nonresponders) in both groups showed improvements in total and subjective eye score and a decrease in eye-muscle volume. Response to either treatment was due largely to changes in soft-tissue involvement and eye-muscle motility. Radiotherapy and oral prednisone appear to be equally effective as initial treatment in patients with moderately severe Graves' ophthalmopathy. In view of its better tolerability, radiotherapy should be considered the treatment of first choice.

Prummel, M.F.; Mourits, M.; Blank, L.; Berghout, A.; Koornneef, L.; Wiersinga, W.M. (Univ. of Amsterdam (Netherlands))

1993-10-16

63

Retrobulbar T cells from patients with Graves' ophthalmopathy are CD8+ and specifically recognize autologous fibroblasts.  

PubMed Central

Graves' ophthalmopathy is an autoimmune condition characterized by T cell infiltration of the retrobulbar tissue. Phenotypic and functional analysis of these infiltrating cells may provide insight into the pathogenesis of the disease. IL-2-responsive cells were therefore grown out of the retrobulbar tissue from two patients with severe Graves' ophthalmopathy undergoing orbital decompression surgery, and six T cell lines were established and characterized. They consisted predominantly of CD8 + CD45RO+ cells and secreted IL-4, IFN-gamma, and IL-10 upon activation. When screened for their antigen reactivity, all lines proliferated in response to stimulation with autologous retrobulbar fibroblasts in an HLA class I-restricted manner, but did not recognize autologous peripheral blood mononuclear cells, crude eye muscle extract, allogeneic cells, or purified protein derivate of Mycobacterium tuberculosis. In contrast, PBMC from the same patients responded readily to purified protein derivate of Mycobacterium tuberculosis and allogeneic PBMC, but did not recognize autologous fibroblasts. Interestingly, only one of the six retrobulbar T cell lines displayed cytotoxicity towards its specific target cell population. These results suggest that the retrobulbar fibroblasts are a major T cell target in Graves' ophthalmopathy. Pronounced cytokine production in the absence of target cell cytotoxicity may explain fibroblast proliferation, glycosaminoglycan secretion, and secondary eye muscle enlargement in this condition. Images

Grubeck-Loebenstein, B; Trieb, K; Sztankay, A; Holter, W; Anderl, H; Wick, G

1994-01-01

64

Wide-field photometry at 20 Hz for the TAOS II Project  

NASA Astrophysics Data System (ADS)

The TAOS II Project requires high-speed differential photometry of 10-20 thousand stars over a telescope field of 154mm diameter with 16-micron spatial resolution and good noise performance. We are developing a custom CMOS imager array to accomplish this task.

Geary, John C.; Wang, Shiang-Yu; Lehner, Matthew J.; Jorden, Paul; Fryer, Martin

2012-09-01

65

77 FR 31036 - Notice of Availability of the Record of Decision for the Taos Resource Management Plan...  

Federal Register 2010, 2011, 2012, 2013

...nm/taos. Copies of the ROD/Approved RMP are available for public inspection at the BLM New Mexico State Office at 301 Dinosaur Trail, Santa Fe, New Mexico. FOR FURTHER INFORMATION CONTACT: Brad Higdon, Planning and Environmental Coordinator,...

2012-05-24

66

MiniTAO\\/MAX38 first light: 30-micron band observations from the ground-based telescope  

Microsoft Academic Search

We successfully carried out 30-micron observations from the ground-based telescope for the first time with our newly developed mid-infrared instrument, MAX38, which is mounted on the University of Tokyo Atacama 1.0-m telescope (miniTAO telescope). Thanks to the high altitude of the miniTAO (5,640m) and dry weather condition of the Atacama site, we can access the 30-micron wavelength region from ground-based

Tomohiko Nakamura; Takashi Miyata; Shigeyuki Sako; Kentaro Asano; Mizuho Uchiyama; Toshihiko Tanabe; Mizuki Yoneda; Yoshifusa Ita; Takashi Onaka; Hirokazu Kataza; Tsutomu Aoki; Mamoru Doi; Toshihiro Handa; Daisuke Kato; Kimiaki Kawara; Kotaro Kohno; Masahiro Konishi; Shintaro Koshida; Takeo Minezaki; Natsuko Mitani; Kentaro Motohara; Ryo Ohsawa; Takao Soyano; Masuo Tanaka; Ken'ichi Tarusawa; Koji Toshikawa; Yuzuru Yoshii

2010-01-01

67

Efficacy of 99mTc-EDDA/HYNIC-TOC SPECT/CT scintigraphy in Graves' ophthalmopathy  

PubMed Central

The aim of this study was to investigate the predictive role of the orbital somatostatin receptor scintigraphy with 99mTc-EDDA/HYNIC-TOC (99mTc-TOC) to detect clinical stage of Graves’ ophthalmopathy and the response to corticosteroid therapy. The subjects of the experiment were 46 patients with Graves’ ophthalmopathy (GO) and four volunteers without eye disease or GO as the normal group (NG). Single photon emission computed tomography (SPECT), computed tomography (CT) and the left and right lateral position planar imaging of the heads of the all subjects were obtained 4 h after the intravenous injection of 555 MBq of 99mTc-TOC. The 99mTc-TOC SPECT/CT was repeated 3 months later. 35 (35/46) patients were received corticosteroid therapy (prednisolone, 10 mg po tid ) for 3 months, however, the other 11 patients as control groups did not receive any treatment. The treatment effect was evaluated both by the orbital 99mTc-TOC uptake and NOSPECS. A significant decrease in the O/OC ratio was observed in 22 GO patients between pre- and post-treatment (1.64 ± 0.13 vs. 1.21 ± 0.09, P < 0.05). There were neither significant difference of the O/OC ratio in 13 GO patients between pre- and post-treatment periods, nor significant difference in the 9 (9/11) patients before and after three months. Orbital 99mTc-TOC scintigraphy is a feasible technique to estimate the Graves’ ophthalmopathy activity and predict the response to subsequent corticosteroid therapy in GO patients. The technique could be a useful tool for physicians not familiar with CAS determination.

Zhao, Rong; Wang, Jiang; Deng, Jinglan; Yang, Weidong; Wang, Jing

2012-01-01

68

Immunotherapy in miscellaneous medical disorders Graves ophthalmopathy, asthma, and regional painful syndrome.  

PubMed

In Graves ophthalmopathy, immunotherapy is offering an opportunity of reducing bad outcomes that lead to disfigurement and impairment of vision. These therapies are not perfect; however, we now have a chance to achieve better outcomes. In asthma, immune therapy using passive immunity targeting key proinflammatory cytokine/chemokines and medications of their effects has opened an avenue of research into a safe and durable therapy. Omalizumab appears to be safe and effective in clinical use. In regional pain syndrome, immune mechanisms may be involved in sustaining long-standing pain, and IVIG may moderate pain sensitivity by reducing immune activation. PMID:22703859

Gonzales, Michael; Fratianni, Carmel; Mamillapali, Chaitanya; Khardori, Romesh

2012-05-01

69

Ocular Changes and Approaches of Ophthalmopathy in Basedow - Graves- Parry- Flajani Disease  

PubMed Central

ABSTRACT Basedow-Graves disease is an autoimmune condition with multiple local and systemic aspects. Among these, oculopathy has a major impact on patient's life from both functional and esthetic point of view. Basedow-Graves oculopathy requires an appropriate positive and differential diagnosis using clinical and imagistic approaches. Treatment is always required in moderate or severe forms and it begins with simple general points and continues with medical and surgical therapies. Current article stresses upon the most characteristic clinical signs of thyroidian ophthalmopathy and the required current therapeutic approaches.

SARACI, George; TRETA, Anamaria

2011-01-01

70

Performance assessment of Tao–Mason equation of state: Results for vapor–liquid equilibrium properties  

Microsoft Academic Search

The present work evaluates the performance of a molecular-based equation of state in predicting thermodynamic properties of several fluids in a very wide range of temperatures encompassing 100KTao–Mason (TM) which is based on statistical mechanical perturbation theory. The 21 fluids including: argon (Ar),

Mohammad Mehdi Papari; Masoumeh Kiani; Jalil Moghadasi

2011-01-01

71

Curanderismo in Taos County, New Mexico--a possible case of anthropological romanticism?  

PubMed

Interviews with 25 Spanish-Americans of Taos County, New Mexico, indicate that time and acculturation have greatly eroded the belief in and practice of curanderismo, the traditional folk medical system of the Southwest. Curanderismo in northern New Mexico today has moved from being a primary and important source of medical care to one used alternatively and very occasionally in cases of pediatric disorders, chronic illnesses and pain, and for those maladies still classified according to the traditional folk beliefs. PMID:6666104

Scheper-Hughes, N; Stewart, D

1983-12-01

72

Impacts of XBT, TAO, altimetry and ARGO observations on the tropical Pacific Ocean data assimilation  

Microsoft Academic Search

This study aims at assessing the relative impacts of four major components of the tropical Pacific Ocean observing system\\u000a on assimilation of temperature and salinity fields. Observations were collected over a period between January 2001 through\\u000a June 2003 including temperature data from the expendable bathythermographs (XBT), thermistor data from the Tropical Ocean\\u000a Global Atmosphere Tropical Atmosphere-Ocean (TOGA-TAO) mooring array, sea

Changxiang Yan; Jiang Zhu; Guangqing Zhou

2007-01-01

73

JNK Pathway Activation Is Controlled by Tao/TAOK3 to Modulate Ethanol Sensitivity  

PubMed Central

Neuronal signal transduction by the JNK MAP kinase pathway is altered by a broad array of stimuli including exposure to the widely abused drug ethanol, but the behavioral relevance and the regulation of JNK signaling is unclear. Here we demonstrate that JNK signaling functions downstream of the Sterile20 kinase family gene tao/Taok3 to regulate the behavioral effects of acute ethanol exposure in both the fruit fly Drosophila and mice. In flies tao is required in neurons to promote sensitivity to the locomotor stimulant effects of acute ethanol exposure and to establish specific brain structures. Reduced expression of key JNK pathway genes substantially rescued the structural and behavioral phenotypes of tao mutants. Decreasing and increasing JNK pathway activity resulted in increased and decreased sensitivity to the locomotor stimulant properties of acute ethanol exposure, respectively. Further, JNK expression in a limited pattern of neurons that included brain regions implicated in ethanol responses was sufficient to restore normal behavior. Mice heterozygous for a disrupted allele of the homologous Taok3 gene (Taok3Gt) were resistant to the acute sedative effects of ethanol. JNK activity was constitutively increased in brains of Taok3Gt/+ mice, and acute induction of phospho-JNK in brain tissue by ethanol was occluded in Taok3Gt/+ mice. Finally, acute administration of a JNK inhibitor conferred resistance to the sedative effects of ethanol in wild-type but not Taok3Gt/+ mice. Taken together, these data support a role of a TAO/TAOK3-JNK neuronal signaling pathway in regulating sensitivity to acute ethanol exposure in flies and in mice.

Zou, Mimi E.; Lim, Jana P.; Heberlein, Ulrike; Wolf, Fred W.

2012-01-01

74

Tao-Sheng's Commentary on the Saddharmapundar?ka-S?tra: A Study and Translation  

Microsoft Academic Search

This dissertation provides a comprehensive study and complete translation of Tao-sheng's Commentary on the Saddharmapundar?ka-S?tra (CSPS). This document occupies an important place in Chinese Buddhist literature. Its significance in the study of Chinese Buddhism can be described in two ways. Firstly, the CSPS was the first commentary ever written on the Lotus S?tra, which was to become a scripture of

Young-Ho Kim

1985-01-01

75

Ocean Data Assimilation and El Ni ˜ no Prediction using TAO\\/TRITON Buoy Data  

Microsoft Academic Search

The present status of the use of TAO\\/TRITON-observed data in a global ocean data assimilation system of the Japan Meteorological Agency (JMA) is reported. The results of the system are presented mainly focusing on salinity data assimilation. The outputs of data assimilation are verified with TOPEX\\/POSEIDON altimetry data, and a coupled ocean-atmosphere model is also integrated to investigate the impact

Masayoshi Ishii; Kenji Sakamoto; Masahide Kimoto

76

Radionuclide concentrations in soils and produce from Cochiti, Jemez, Taos, and San Ildefonso Pueblo Gardens  

SciTech Connect

Radionuclide ({sup 3}H, {sup 90}Sr, {sup 137}Cs, {sup 238}Pu, {sup 239}Pu, and total uranium) concentrations were determined in soils and produce collected from Cochiti, Jemez, Taos, and San Ildefonso Pueblo gardens. All radionuclides in soils from Pueblo areas were within or just above regional statistical (natural and/or worldwide fallout) reference levels. Similarily, the average levels of radionuclides in produce collected from Cochiti, Jemez, Taos, and San Ildefonso Pueblo gardens were not significantly different in produce collected from regional (background) locations. The effective (radiation) dose equivalent from consuming 352 lb of produce from Cochiti, Jemez, Taos, and San Ildefonso, after natural background has been subtracted, was 0.036 ({+-}0.016), 0.072 ({+-}0.051), 0.012 ({+-}0.027), and 0.110 ({+-}0.102) mrem/yr, respectively. The highest calculated dose, based on the mean + 2 std dev (95% confidence level), was 0.314 mrem/yr; this was <0.4% of the International Commission on Radiological Protection permissible dose limit for protecting members of the public.

Fresquez, P.R.; Armstrong, D.R.; Salazar, J.G.

1995-05-01

77

[Clinical results with a complex conservative treatment method in infiltrative ophthalmopathy (preliminary report)].  

PubMed

The present methods for the treatment of infiltrative ophthalmopathy are still unsatisfactory, some of them associated with considerable and lasting side effects. Clinical results are present in the communication, from the application of an original therapeutic complex, consisting in the parallel administration of ACTH, intravenous infusions, moderate doses cortison, diuretics and sanation via antibiotics and eventual surgical intervention of the existing focal infectious agents. The complex is applied in the course of 4 weeks. Regression of the clinical symptomatics is observed and assessed by a particular method, it reaches an average of about 50 per cent of the initial manifestations. In 45 per cent of the patients the result was assessed as very good and excellent. The subjective complaints, congestion, chemosis and edema are best and most rapidly influenced, whereas exophthalmos and the eventual ophthalmoplegic phenomena showed no essential changes. The correlations between the results obtained, accompanying the disease (Basedow disease, focal infections) and the severity of ophthalmopathy were discussed. The method was admitted to be perspective, harmless and could ensure good and lasting therapeutic results of properly and persistently applied. PMID:6275612

Bozadzhieva, E; V?rbanov, V; Denev, V; Ovcharova, N; Pe?cheva, E

1981-01-01

78

Protracted Hypofractionated Radiotherapy for Graves' Ophthalmopathy: A Pilot Study of Clinical and Radiologic Response  

SciTech Connect

Purpose: To evaluate the clinical and radiologic response of patients with Graves' ophthalmopathy given low-dose orbital radiotherapy (RT) with a protracted fractionation. Methods and Materials: Eighteen patients (36 orbits) received orbital RT with a total dose of 10 Gy, fractionated in 1 Gy once a week over 10 weeks. Of these, 9 patients received steroid therapy as well. Patients were evaluated clinically and radiologically at 6 months after treatment. Clinical response assessment was carried out using three criteria: by physical examination, by a modified clinical activity score, and by a verbal questionnaire considering the 10 most common signs and symptoms of the disease. Radiologic response was assessed by magnetic resonance imaging. Results: Improvement in ocular pain, palpebral edema, visual acuity, and ocular motility was observed in all patients. Significant decrease in symptoms such as tearing (p < 0.001) diplopia (p = 0.008), conjunctival hyperemia (p = 0.002), and ocular grittiness (p = 0.031) also occurred. Magnetic resonance imaging showed decrease in ocular muscle thickness and in the intensity of the T2 sequence signal in the majority of patients. Treatments were well tolerated, and to date no complications from treatment have been observed. There was no statistical difference in clinical and radiologic response between patients receiving RT alone and those receiving RT plus steroid therapy. Conclusion: RT delivered in at a low dose and in a protracted scheme should be considered as a useful therapeutic option for patients with Graves' ophthalmopathy.

Casimiro de Deus Cardoso, Cejana; Giordani, Adelmo Jose [Department of Clinical and Experimental Oncology, Division of Radiotherapy, Federal University of Sao Paulo, Sao Paulo, SP (Brazil); Borri Wolosker, Angela Maria [Department of Radiology, Federal University of Sao Paulo, Sao Paulo, SP (Brazil); Souhami, Luis [Department of Radiotherapy, McGill University Heath Centre, Montreal, Quebec (Canada); Gois Manso, Paulo [Department of Ophthalmology, Federal University of Sao Paulo, Sao Paulo, SP (Brazil); Souza Dias, Rodrigo; Comodo Segreto, Helena Regina [Department of Clinical and Experimental Oncology, Division of Radiotherapy, Federal University of Sao Paulo, Sao Paulo, SP (Brazil); Araujo Segreto, Roberto, E-mail: segreto.dmed@epm.br [Department of Clinical and Experimental Oncology, Division of Radiotherapy, Federal University of Sao Paulo, Sao Paulo, SP (Brazil)

2012-03-01

79

Case 3. "Jiang Tao v. Chengdu Branch, People's People's Bank of China": Opinion by the People's Court in Wuhou District, Chengdu, Sichuan Province  

ERIC Educational Resources Information Center

|This article presents the decision of the People's Court in Wuhou District, Chengdu, Sichuan Province on the Jiang Tao v. Chengdu Branch, People's People's Bank of China case. Jiang Tao, the plaintiff, claimed that the defendant Chengdu Branch placed an announcement in the "Chengdu Business Daily" to "recruit tellers for Chengdu Branch" on…

Chinese Education and Society, 2006

2006-01-01

80

Pressure-induced amorphization of La1/3TaO3  

NASA Astrophysics Data System (ADS)

La1/3TaO3, an A-site cation deficient perovskite, has been studied under pressure by synchrotron X-ray powder diffraction and Raman spectroscopy. It undergoes irreversible pressure induced amorphization at P=18.5 GPa. An almost linear unit cell volume decrease vs. pressure is observed from ambient pressure up to the phase transition. The Raman spectroscopy also shows amorphization at the same pressure, with positive shifts of all modes as a function of pressure. The pressure dependence of the Eg and A1g Raman modes arising from the octahedral oxygen network is discussed.

Noked, O.; Melchior, A.; Shuker, R.; Livneh, T.; Steininger, R.; Kennedy, B. J.; Sterer, E.

2013-06-01

81

Search for small trans-Neptunian objects by the TAOS project  

NASA Astrophysics Data System (ADS)

The Taiwan-America Occultation Survey (TAOS) aims to conduct a census of small icy bodies in the outer reach of the Solar System, by means of stellar occultation. An array of 4 small (aperture 0.5 m), wide-field (f/1.9) telescopes have been installed at Lulin Observatory in Taiwan to monitor some one thousand stars simultaneously for such rare occultation events. The occurrence rate of the events would provide constraints on the number and space distribution of the Kuiper-belt Objects (KBOs). As the building blocks of planets and moons, KBOs preserve the formation and early dynamical evolution history of the Solar System. The TAOS project is a collaboration of institutions in Taiwan (Academia Sinica and NCU), the USA (U. Pennsylvannia, Harvard-Smithsonian CfA, Lawrence Livermore National Lab, NASA/Ames, UC-Berkeley), and Korea (Yonsei U.) Because a typical occultation event by a KBO is expected to last for only a fraction of a second, fast photometry is necessary. A true occultation event is considered securely detected if the flux drop is seen in all telescopes. Photometry of a thousand stars, for which the data should be processed, analyzed, and correlated among all telescopes in real time, is a daunting task. Routine observations began in early 2005 and so far a few billion photometric measurements have been collected. Even though no KBO occultation event has been detected, a few certain models on the population of the KBOs can be ruled out already. We will present our special data acquisition and analysis schemes and our statistical results. A few test cases will be shown for which the TAOS system was used to detect stellar occultation events by known asteroids. In addition to the KBO science, the huge TAOS database, ~ some 100 GB per night, would be valuable in other, e.g., stellar variability, studies. Our robotic telescope systems are also responding to gamma-ray bursts. We will present a few examples of variable stars observed by

Chen, W. P.; Alcock, C.; Axelrod, T.; Bianco, F. B.; Byun, Y. I.; Chang, Y. H.; Cook, K. H.; Dave, R.; Giammarco, J.; Kim, D. W.; King, S. K.; Lee, T.; Lehner, M.; Lin, C. C.; Lin, H. C.; Lissauer, J. J.; Marshall, S.; Meinshausen, N.; Mondal, S.; de Pater, I.; Porrata, R.; Rice, J.; Schwamb, M. E.; Wang, A.; Wang, S. Y.; Wen, C. Y.; Zhang, Z. W.

2007-05-01

82

Adiponectin concentration in the orbital fat of patients with Graves' ophthalmopathy  

PubMed Central

Background “Graves’ ophthalmopathy” (GO), is an inflammatory disease of the orbit, with extensive adipose tissue involvement. Previous studies of orbital fat derived from such patients have demonstrated overexpression of the adiponectin gene and messenger RNA. Aim The study reported here aimed to measure the protein concentration of orbital adipose tissue adiponectin in GO patients, in comparison to healthy controls. Methods This was a prospective study. Orbital samples from ten healthy controls undergoing blepharoplasty and five patients with GO undergoing orbital fat decompression for proptosis were analyzed by enzyme-linked immunosorbent assay. Results The mean adiponectin concentration in samples from GO patients was 121.9 ± 29.5 ng/mL (mean ± standard deviation), versus 107.9 ± 26.6 ng/mL in the control group (P=0.20). Conclusion This study was unable to demonstrate a statistically significant difference in adiponectin protein concentrations between the two studied groups.

Soiberman, Uri; Levy, Ran; Leibovitch, Igal

2013-01-01

83

Low-Temperature Plasma-Oxidation Process for Reliable Tantalum-Oxide (TaO) Decoupling Capacitors  

Microsoft Academic Search

Low-temperature plasma-oxidation process of ultra-thin PVD-Ta is developed to fabricate MIM capacitors with high-k TaO dielectric through the current Cu-BEOL process. We found that controlling both the oxidation process and micro-structure of the initial Ta to be oxidized is a key to achieve high-quality TaO dielectrics. Laminated TiN\\/Ta\\/TiN bottom electrode with a flat surface in nano-scale contributes to high reliability.

I. Kume; N. Inoue; T. Toda; M. Furumiya; T. Takeuchi; F. Ito; T. Iwaki; S. Shida; Y. Hayashi

2008-01-01

84

Toll-like receptor gene polymorphisms are associated with susceptibility to graves' ophthalmopathy in Taiwan males  

PubMed Central

Background Toll-like receptors (TLRs) are a family of pattern-recognition receptors, which plays a role in eliciting innate/adaptive immune responses and developing chronic inflammation. The polymorphisms of TLRs have been associated with the risk of various autoimmune diseases, including systemic lupus erythematosus (SLE), multiple sclerosis and rheumatorid arthritis. The aim of this study was to evaluate whether TLR genes could be used as genetic markers for the development of Graves' ophthalmopathy (GO). Methods 6 TLR-4 and 2 TLR-9 gene polymorphisms in 471 GD patients (200 patients with GO and 271 patients without GO) from a Taiwan Chinese population were evaluated. Results No statistically significant difference was observed in the genotypic and allelic frequencies of TLR-4 and TLR-9 gene polymorphisms between the GD patients with and without GO. However, sex-stratified analyses showed that the association between TLR-9 gene polymorphism and GO phenotype was more pronounced in the male patients. The odds ratios (ORs) was 2.11 (95% confidence interval [CI] = 1.14-3.91) for rs187084 AàG polymorphism and 1.97 (95% CI = 1.07-3.62) for rs352140 AàG polymorphism among the male patients. Increasing one G allele of rs287084 and one A allele of rs352140 increased the risk of GO (p values for trend tests were 0.0195 and 0.0345, respectively). Further, in haplotype analyses, the male patients carrying the GA haplotype had a higher risk of GO (odds ratio [OR] = 2.02, 95% confidence interval [CI] = 1.09-3.73) than those not carrying the GA haplotype. Conclusion The present data suggest that TLR-9 gene polymorphisms were significantly associated with increased susceptibility of ophthalmopathy in male GD patients.

2010-01-01

85

Transconjunctival orbital decompression in Graves' ophthalmopathy: lateral wall approach ab interno  

PubMed Central

AIMS—A modified surgical technique is described to perform a one, two, or three wall orbital decompression in patients with Graves' ophthalmopathy.?METHODS—The lateral wall was approached ab interno through a "swinging eyelid" approach (lateral canthotomy and lower fornix incision) and an extended periosteum incision along the inferior and lateral orbital margin. In addition, the orbital floor and medial wall were removed when indicated. To minimise the incidence of iatrogenic diplopia, the lateral and medial walls were used as the first surfaces of decompression, leaving the "medial orbital strut" intact. During 1998, this technique was used in a consecutive series of 19 patients (35 orbits) with compressive optic neuropathy (six patients), severe exposure keratopathy (one patient), or disfiguring/congestive Graves' ophthalmopathy (12 patients).?RESULTS—The preoperative Hertel value (35 eyes) was on average 25 mm (range 19-31 mm). The mean proptosis reduction at 2 months after surgery was 5.5 mm (range 3-7 mm). Of the total group of 19 patients, iatrogenic diplopia occurred in two (12.5%) of 16 patients who had no preoperative diplopia or only when tired. The three other patients with continuous preoperative diplopia showed no improvement of double vision after orbital decompression, even when the ocular motility (ductions) had improved. In the total group, there was no significant change of ductions in any direction at 2 months after surgery. All six patients with recent onset compressive optic neuropathy showed improvement of visual acuity after surgery. No visual deterioration related to surgery was observed in this study. A high satisfaction score (mean 8.2 on a scale of 1 to 10) was noted following the operation.?CONCLUSION—This versatile procedure is safe and efficacious, patient and cost friendly. Advantages are the low incidence of induced diplopia and periorbital hypaesthesia, the hidden and small incision, the minimal surgical trauma to the temporalis muscle, and fast patient recovery. The main disadvantage is the limited exposure of the posterior medial and lateral wall.??

Paridaens, D.; Verhoeff, K.; Bouwens, D.; van den Bosch, W. A

2000-01-01

86

Rhizome of Anemarrhena asphodeloides counteracts diabetic ophthalmopathy progression in streptozotocin-induced diabetic rats.  

PubMed

Diabetic ophthalmopathy (DO) impairs patients' eyesight and even causes blindness. Here, we investigated the effect of 60% ethanol extract of the rhizome of Anemarrhenae asphodeloides (ERA), which is commonly used in Chinese medicine formulae in treating diabetes, on DO progression. Blood glucose, insulin, advanced glycation end products (AGE), super oxygen dehydrogenises (SOD), malondialdehyde (MDA) and glutathione peroxidase (GSH-Px) levels in serum and sorbitol concentration in the lens were measured. Retinal endothelium/pericyte (E/P) ratio was evaluated, and structural changes of the retina and lens were observed. Effects of mangiferin and neomangiferin, the two major components of ERA, on subnormal growth of pericytes induced by high glucose were also detected. It was found that the activities of SOD and GSH-Px in serum were increased, whereas MDA and AGE levels in serum and sorbitol concentration in the lens were decreased in ERA-treated DO rats. E/P ratio was decreased, and the pathological changes of the lens and retina were alleviated by ERA treatment. Moreover, the subnormal growth of pericytes induced by high glucose was ameliorated by mangiferin and neomangiferin. These results indicated that ERA could effectively prevent DO progression in streptozotocin-induced diabetic rats, and mangiferin and neomangiferin may be the main effective components. PMID:23148017

Li, Xuan; Cui, Xiaobing; Wang, Jinjin; Yang, Jie; Sun, Xiaoyu; Li, Xiaodong; Zhu, Quan; Li, Wei

2012-11-12

87

The Evolving Role of Selenium in the Treatment of Graves' Disease and Ophthalmopathy  

PubMed Central

Graves' disease (GD) and ophthalmopathy (GO) are organ-specific autoimmune-inflammatory disorders characterized by a complex pathogenesis. The inflammatory process is dominated by an imbalance of the antioxidant-oxidant mechanism, increased production of radical oxygen species (ROS), and cytokines which sustain the autoimmune process and perpetuate the disease. Recently, selenium, which is a powerful antioxidant, has been successfully applied in patients with mild GO, slowing the progression of disease, decreasing the clinical activity score, and appreciably improving the quality of life. The mechanisms of selenium action are variable. The aim of this review is to summarize the actions of selenium in GD and GO. Selenium as selenocysteine is incorporated in selenoproteins, such as glutathione peroxidase which catalyzes the degradation of hydrogen peroxide and lipid hydroperoxide that are increasingly produced in hyperthyroidism. Moreover, selenium decreases the formation of proinflammatory cytokines, while it contributes, in synergy with antithyroid drugs, to stabilization of the autoimmune process in GD and alleviation of GO. It is now to be clarified whether enforced nutritional supplementation has the same results and whether prolonging selenium administration may have an impact on the prevention of disease.

Duntas, Leonidas H.

2012-01-01

88

Association of IL12B polymorphisms with susceptibility to Graves ophthalmopathy in a Taiwan Chinese population  

PubMed Central

Background Interleukin 12B (IL12B) gene polymorphisms have been linked to several inflammatory diseases, but their role in the development of Graves ophthalmopathy (GO) in Graves disease (GD) patients is unclear. The purpose of this study was to investigate the disease association of IL12B single nucleotide polymorphisms (SNPs). Methods A Taiwan Chinese population comprising 200 GD patients with GO and 271 GD patients without GO was genotyped using an allele-specific extension and ligation method. Hardy-Weinberg equilibrium was estimated using the chi-square test. Allele and genotype frequencies were compared between GD patients with and without GO using the chi-square test. Results The genotype and allele frequencies of examined SNPs did not differ between GD patients with and without GO. Although the genotype distribution remained nonsignificant in the sex-stratified analyses, the frequency of the T allele at SNP rs1003199 was significantly higher in patients with GO in the male cohort (P = 6.00 × 10-3). In addition, haplotypes of IL12B may be used to predict the risk of GO (P = 1.70 × 10-2); however, we could not prove the statistical significance of analysis after applying the Bonferroni correction. Conclusions Our results provide new information that the examined IL12B gene polymorphisms may be associated with susceptibility to GO in the Taiwan Chinese population in a sex-specific manner. This conclusion requires further investigation.

2012-01-01

89

Structural Characterization of New Layered Perovskites MLa 2Ti 2TaO 10 ( M=Cs, Rb) and NaLa 2Ti 2TaO 10 · xH 2O ( x=2, 0.9, 0)  

Microsoft Academic Search

The crystal structures of n=3 Dion–Jacobson phases MLa2Ti2TaO10 (M=Cs, Rb) and NaLa2Ti2TaO10 ·xH2O (x=2, 0.9, 0) have been investigated by the Rietveld analysis of their powder XRD patterns. These compounds show the new-type ordering sequence of (Ti1\\/2Ta1\\/2)O6–TiO6–(Ti1\\/2Ta1\\/2)O6 in the tripled octahedra, corresponding to the niobium analogs of MLa2Ti2NbO10. They crystallize in the tetragonal system P4\\/mmm with lattice constants of a=3.84733(9)

Young-Sik Hong; Chi-Hwan Han; Keon Kim

2001-01-01

90

Synthesis, crystal structure, and photocatalytic activity of the new three-layer aurivillius phases, Bi2ASrTi2TaO12 (A=Bi, La)  

NASA Astrophysics Data System (ADS)

Two new three-layer Aurivillius phases Bi2ASrTi2TaO12 (A=Bi, La) have been synthesized. The detailed structure determination of Bi2ASrTi2TaO12 (A=Bi, La) performed by powder X-ray diffraction (XRD) and selected area electron microscopy (SAED) shows that they all crystallize in the space group I/4mmm. UV-visible diffuse reflection spectrum of the prepared Bi2ASrTi2TaO12 (A=Bi, La) indicates that it had absorption in the ultraviolet (UV) region. The photocatalytic activity of the Bi2ASrTi2TaO12 (A=Bi, La) powders was evaluated by degradation of rhodamine B (RB) molecules in water under UV light irradiation. The results showed that Bi2ASrTi2TaO12 (A=Bi, La) has high photocatalytic activity at room temperature. Therefore, the preparation and properties studies of Bi2ASrTi2TaO12 (A=Bi, La) with a three-layer Aurivillius structure suggest potential future applications in photocatalysis.

Wang, Dong; Tang, Kaibin; Liang, Zhenhua; Zheng, Huagui

2010-02-01

91

Automated classification of single airborne particles from two-dimension, angle-resolved optical scattering (TAOS) patterns  

NASA Astrophysics Data System (ADS)

Two-dimension, angle-resolved optical scattering (TAOS) is an experimental technique by which patterns of LASER light intensity scattered by single (micrometer or sub-micrometer sized) airborne particles are collected. In the past 10 years TAOS instrumentation has evolved from laboratory prototypes to field-deployable equipment; patterns are collected by the thousands during indoor or outdoor sampling in short times. Although comparison between experimental and computed scattering patterns has been carried out extensively, there is no satisfactory way to relate a given pattern to the particle it comes from. This paper reports about the ongoing development and implementation of a method which is aimed at classifying patterns, rather than identifying original particles. A machine learning algorithm includes the extraction of morphological features and their multivariate statistical analysis. A classifier is trained and validated in a supervised mode, by relying on patterns from known materials. Then the tuned classifier is applied to the recognition of patterns of unknown origin.

Crosta, Giovanni F.; Pan, Yong-Le; Chang, Richard K.

2011-05-01

92

Spectroscopic properties of Y3TaO7 powders activated with Eu, Er and co-activated with Yb  

Microsoft Academic Search

A new synthesis method of Y3TaO7 is reported. Pure phase powders were prepared by modified Pechini technique. Precursors obtained through that route were heated at the temperature about 1000°C with or without use of Li2SO4 flux. That implicates in different morphology of specimens and also their spectroscopic properties. Eu ions were used as a spectroscopic probe to prove inhomogeneous broadening

Adam Walasek; Eugeniusz Zych; An Liqiong; Jian Zhang; Shiwei Wang

2007-01-01

93

Understanding the resistive switching in thin-film Ta-O memristors by their d.c. switching characteristics  

NASA Astrophysics Data System (ADS)

Tantalum oxide (Ta-O) memristor is a promising candidate for resistive switching memory (RRAM) technology as they have demonstrated outstanding features such as high endurance, high speed, and low power. However, the responsible mechanisms remain vague partly due to difficulties in characterizing the amorphous film structure, nanoscale active regions, coupled ionic and electronic transport, and intertwined electrochemical and thermochemical processes. Rich information about Ta-O memristors has been revealed by microscopic structural and chemical characterizations of Ta-O conduction channels combined with temperature-dependent transport measurements. As an alternative approach, we took perspectives from a statistical study of the switching behavior under d.c. excitation. We identified distinctive behaviors in device switching characteristics depending on the chemical compositions of conductance channel, and found close correlations with previous temperature-dependent transport measurements and X-ray photoemission (XPS) characterizations. We were able to gather further insight into the microscopic switching mechanisms based on these observations, revealing the granularity of the switching phenomena.

Yi, Wei; Medeiros-Ribeiro, Gilberto; Miao, Feng; Goldfarb, Ilan; Zhang, Max; Yang, J. Joshua; Pickett, Matthew D.; Strachan, John Paul; Williams, R. Stanley

2012-02-01

94

Fenofibrate increases the expression of high mobility group AT-hook 2 (HMGA2) gene and induces adipocyte differentiation of orbital fibroblasts from Graves' ophthalmopathy  

Microsoft Academic Search

Expansion of adipose tissue in the orbits is a key feature of Graves' ophthalmopathy. Recent evidence shows that orbital fibroblasts are committed to differentiate into adipocytes under appropriate stimuli. Rosiglitazone, an agonist of the nuclear hormone receptor, peroxisome proliferator-activated receptor (PPAR) is able to induce both differentiation of orbital fibroblasts into mature adipocytes and expression of the TSH receptor (TSHr)

Daniela Pasquali; Giovanna Maria Pierantoni; Alfredo Fusco; Stefania Staibano; Vittorio Colantuoni; Annamaria De Bellis; Antonio Bellastella; Antonio Agostino Sinisi

2004-01-01

95

Molecular cloning and characterization of genes for antibodies generated by orbital tissue-infiltrating B-cells in Graves` ophthalmopathy  

SciTech Connect

Graves` ophthalmopathy is a distressing autoimmune disease of unknown etiology. Analysis of the genes for antibodies secreted by orbital tissue-infiltrating plasma cells might provide insight into the pathogenesis of this disease. The authors, therefore, constructed an immunoglobulin heavy (H) chain and an immunoglobulin k light (L) chain cDNA library from the orbital tissue of a patient with active Graves` ophthalmopathy. Analysis of 15 H (IgG1) and 15 L (k) chains revealed a restricted spectrum of variable region genes. Fourteen of 15 variable k genes were about 94% homologous to the closest known germline gene, KL012. Thirteen of 15 H chain genes were 91% and 90% homologous to the closest germline genes, DP10 and hv1263, respectively. Remarkably, these germline genes also code for other autoantibodies to striated muscle (KL012) and thyroid peridase (KL012 and hv1263). These studies raise the possibility that particular germline genes may be associated with autoimmunity in humans. Further, the present study opens the way to identifying ocular autoantigens that may be the target of an humoral immune response. 29 refs., 4 figs., 1 tab.

Jaume, J.C.; Portolano, S.; Prummel, M.F.; McLachlan, S.M.; Rapoport, B. [Univ. of California, San Francisco, CA (United States)

1994-02-01

96

Upper eyelid retraction in Graves' ophthalmopathy: a new surgical technique and a study of the abnormal levator muscle.  

PubMed Central

A new surgical procedure, the proximal levator technique, achieves recession of the retracted upper eyelid in Graves' ophthalmopathy by sectioning the levator muscle proximal to Whitnall's ligament and fixing eyelid position with sutures that permit postoperative adjustment. This technique deserves further study. Enlargement of the proximal levator muscle in Graves' eye disease is shown on orbital CT scans and is found at surgery when the proximal levator technique is employed. Histologic and morphometric studies demonstrate increased levator muscle fiber size as well as increased extracellular volume. These findings suggest that levator muscle hypertrophy is important in the pathogenesis of upper eyelid retraction in Graves' ophthalmopathy. Images FIGURE 2 A FIGURE 3 A FIGURE 3 B FIGURE 3 C FIGURE 3 D FIGURE 4 A,B FIGURE 4 C,D,E FIGURE 4 F,G FIGURE 6 A FIGURE 6 B FIGURE 7 A FIGURE 7 B FIGURE 8 A FIGURE 8 B FIGURE 9 A FIGURE 9 B FIGURE 10 A FIGURE 10 B FIGURE 11 A FIGURE 11 B FIGURE 12 A FIGURE 12 B FIGURE 13 A FIGURE 13 B FIGURE 14 A FIGURE 14 B FIGURE 15 A FIGURE 15 B FIGURE 16 A FIGURE 16 B FIGURE 17 A FIGURE 17 B FIGURE 18 A FIGURE 18 B FIGURE 19 A FIGURE 19 B FIGURE 20 FIGURE 21 FIGURE 22 FIGURE 23 FIGURE 24 FIGURE 25 FIGURE 26 FIGURE 27 FIGURE 28 FIGURE 29 FIGURE 30 FIGURE 31 FIGURE 32

Small, R G

1988-01-01

97

Search for Small Trans-Neptunian Objects by the TAOS Project  

SciTech Connect

The Taiwan-America Occultation Survey (TAOS) aims to determine the number of small icy bodies in the outer reach of the Solar System by means of stellar occultation. An array of 4 robotic small (D=0.5 m), wide-field (f/1.9) telescopes have been installed at Lulin Observatory in Taiwan to simultaneously monitor some thousand of stars for such rare occultation events. Because a typical occultation event by a TNO a few km across will last for only a fraction of a second, fast photometry is necessary. A special CCD readout scheme has been devised to allow for stellar photometry taken a few times per second. Effective analysis pipelines have been developed to process stellar light curves and to correlate any possible flux changes among all telescopes. A few billion photometric measurements have been collected since the routine survey began in early 2005. Our preliminary result of a very low detection rate suggests a deficit of small TNOs down to a few km size, consistent with the extrapolation of some recent studies of larger (30-100 km) TNOs.

Chen, Wen-Ping; Alcock, C.; Axelrod, T.; Bianco, F.B.; Byun, Y.I.; Chang, Y.H.; Cook, K.H.; Dave, R.; Giammarco, J.; Kim, D.W.; King, S.K.; Lee, T.; Lehner, M.; Lin, C.C.; Lin, H.C.; Lissauer, J.J.; Marshall, S.; Meinshausen, N.; Mondal, S.; de Pater, I.; Porrata, R.; /Taiwan, Natl. Central U. /Harvard-Smithsonian Ctr. Astrophys. /Arizona U. /Yonsei U. /LLNL, Livermore /Pennsylvania U. /Taipei, Inst. Astron. Astrophys. /NASA, Ames /SLAC /UC, Berkeley /Caltech

2006-12-04

98

American Association of Clinical Endocrinologists, Associazione Medici Endocrinologi, and European Thyroid Association medical guidelines for clinical practice for the diagnosis and management of thyroid nodules.  

PubMed

American Association of Clinical Endocrinologists, Associazione Medici Endocrinologi, and European Thyroid Association medical guidelines for clinical practice for the diagnosis and management of thyroid nodules are systematically developed statements to assist health care professionals in medical decision making for specific clinical conditions. Most of the content herein is based on literature reviews. In areas of uncertainty, professional judgment was applied. These guidelines are a working document that reflects the state of the field at the time of publication. Because rapid changes in this area are expected, periodic revisions are inevitable. We encourage medical professionals to use this information in conjunction with their best clinical judgment. Any decision by practitioners to apply these guidelines must be made in light of local resources and individual patient circumstances. PMID:20543550

Gharib, H; Papini, E; Paschke, R; Duick, D S; Valcavi, R; Hegedüs, L; Vitti, P

2010-01-01

99

Crystal structure of new Li + ion conducting perovskites: Li 2 x Ca 0.5? x TaO 3 and Li 0.2[Ca 1? y Sr y ] 0.4TaO 3  

Microsoft Academic Search

Two new solid solutions—Li2xCa0.5?xTaO3 (0.05?x?0.25) and Li0.2[Ca1?ySry]0.4TaO3 (0

Quoc Nghi Pham; Marie-Pierre Crosnier-Lopez; Françoise Le Berre; François Fauth; Jean-Louis Fourquet

2004-01-01

100

LG based decision aid for naval tactical action officer's (TAO) workstation  

NASA Astrophysics Data System (ADS)

In the increasingly NetCentric battlespace of the 21st century, Stilman Advanced Strategies Linguistic Geometry software has the potential to revolutionize the way that the Navy fights in two key areas: as a Tactical Decision Aid and for creating a relevant Common Operating Picture. Incorporating STILMAN's software into a prototype Tactical Action Officers (TAO) workstation as a Tactical Decision Aid (TDA) will allow warfighters to manage their assets more intelligently and effectively. This prototype workstation will be developed using human-centered design principles and will be an open, component-based architecture for combat control systems for future small surface combatants. It will integrate both uninhabited vehicles and onboard sensors and weapon systems across a squadron of small surface combatants. In addition, the hypergame representation of complex operations provides a paradigm for the presentation of a common operating picture to operators and personnel throughout the command hierarchy. In the hypergame technology there are game levels that span the range from the tactical to the global strategy level, with each level informing the others. This same principle will be applied to presenting the relevant common operating picture to operators. Each operator will receive a common operating picture that is appropriate for their level in the command hierarchy. The area covered by this operating picture and the level of detail contained within it will be dependent upon the specific tasks the operator is performing (supervisory vice tactical control) and the level of the operator (or command personnel) within the command hierarchy. Each level will inform the others to keep the picture concurrent and up-to-date.

Stilman, Boris; Yakhnis, Vladimir; Umanskiy, Oleg; Boyd, Ron

2005-05-01

101

Spectroscopic properties of Y3TaO7 powders activated with Eu, Er and co-activated with Yb  

NASA Astrophysics Data System (ADS)

A new synthesis method of Y3TaO7 is reported. Pure phase powders were prepared by modified Pechini technique. Precursors obtained through that route were heated at the temperature about 1000°C with or without use of Li2SO4 flux. That implicates in different morphology of specimens and also their spectroscopic properties. Eu ions were used as a spectroscopic probe to prove inhomogeneous broadening of excitation and emission spectra. Samples with Er and Yb doping are also presented. Photoluminescence and up-conversion emissions, under 378 nm and 980 nm excitation respectively, strongly depend on the method of powders synthesis.

Walasek, Adam; Zych, Eugeniusz; Liqiong, An; Zhang, Jian; Wang, Shiwei

2007-08-01

102

Upper Limits on the Number of Small Bodies in Sedna-Like Orbits by the TAOS Project  

SciTech Connect

We present the results of a search for occultation events by objects at distances between 100 and 1000 AU in lightcurves from the Taiwanese-American Occultation Survey (TAOS). We searched for consecutive, shallow flux reductions in the stellar lightcurves obtained by our survey between 7 February 2005 and 31 December 2006 with a total of {approx} 4.5 x 10{sup 9} three-telescope simultaneous photometric measurements. No events were detected, allowing us to set upper limits on the number density as a function of size and distance of objects in Sedna-like orbits, using simple models.

Wang, J; Lehner, M J; Zhang, Z; Bianco, F B; Alcock, C; Chen, W; Axelrod, T; Byun, Y; Coehlo, N K; Cook, K H; Dave, R; de Pater, L; Porrata, R; Kim, D; King, S; Lee, T; Lin, H; Lissauer, J J; Marshall, S L; Protopapas, P; Rice, J A; Schwamb, M E; Wang, S; Wen, C

2009-11-13

103

Activity-Induced Protocadherin Arcadlin Regulates Dendritic Spine Number by Triggering N-Cadherin Endocytosis via TAO2? and p38 MAP Kinases  

PubMed Central

Summary Synaptic activity induces changes in the number of dendritic spines. Here, we report a pathway of regulated endocytosis triggered by arcadlin, a protocadherin induced by electroconvulsive and other excitatory stimuli in hippocampal neurons. The homophilic binding of extracellular arcadlin domains activates TAO2?, a splice variant of the thousand and one amino acid protein kinase 2, cloned here by virtue of its binding to the arcadlin intracellular domain. TAO2? is a MAPKKK that activates the MEK3 MAPKK, which phosphorylates the p38 MAPK. Activation of p38 feeds-back on TAO2?, phosphorylating a key serine required for triggering endocytosis of N-cadherin at the synapse. Arcadlin knockout increases the number of dendritic spines, and the phenotype is rescued by siRNA knockdown of N-cadherin. This pathway of regulated endocytosis of N-cadherin via protocadherin/TAO2?/MEK3/p38 provides a molecular mechanism for transducing neuronal activity into changes in synaptic morphologies.

Yasuda, Shin; Tanaka, Hidekazu; Sugiura, Hiroko; Okamura, Ko; Sakaguchi, Taiki; Tran, Uyen; Takemiya, Takako; Mizoguchi, Akira; Yagita, Yoshiki; Sakurai, Takeshi; De Robertis, E.M.; Yamagata, Kanato

2008-01-01

104

The use of iodine as a thyroidal blocking agent in the event of a reactor accident. Report of the Environmental Hazards Committee of the American Thyroid Association.  

PubMed

In the event of a nuclear reactor accident, radioactive materials could be released into the environment: radioisotopes of iodine could constitute a major component of such a release. Upon such exposure, radioiodines could enter the body and accumulate in an unprotected thyroid gland where they would remain for varying periods of time. A number of methods have been proposed to protect those at risk of exposure. Administration of thyroid-blocking agents (such as potassium iodide) to exposed populations could be effective, but their use has raised a number of questions since there are considerable gaps in the scientific information available about the possible effects of low-level radiation from radioiodine. In addition, there are only limited data available about potential toxic side effects of potassium iodide distributed widely to large, unsupervised populations. Concern about these issues led the American Thyroid Association to appoint a committee of its members with special interest and competence in these areas to review the problems in detail and develop an advisory statement on the questions at issue for those to whom this matter might be of concern. PMID:6737670

Becker, D V; Braverman, L E; Dunn, J T; Gaitan, E; Gorman, C; Maxon, H; Schneider, A B; Van Middlesworth, L; Wolff, J

1984-08-01

105

Development of MIMIZUKU: a mid-infrared multi-field imager for 6.5-m TAO telescope  

NASA Astrophysics Data System (ADS)

TAO (The University of Tokyo Atacama Observatory) is planned to be constructed at the summit of Co. Chajnantor (5640 m altitude) in Chile. MIMIZUKU (Mid-Infrared Multi-field Imager for gaZing at the UnKnown Universe) is a mid-infrared imager (Field of View: 1' x 1'- 2' x 2') and spectrometer (??/?: 60-230) for the 6.5-m TAO telescope, covering the wavelength range of 2-38 ?m. The MIMIZUKU has a unique equipment called Field Stacker (FS) which enables the simultaneous observation of target and reference object. The simultaneity is expected to improve photometric accuracy and to realize long-term monitoring observations. The development status of the MIMIZUKU is reported in this paper. The FS and the cryostat of the MIMIZUKU have been fabricated and under testing. The cold optics (550 mm x 750 mm x 2 floors) with 28 mirrors has been constructed. The mirrors were aligned with the positional precision of 0.1 mm and the angular precision of 0.1 deg. The evaluated optical performance is that the diffraction-limited image at ? <8 ?m and the enough compact image (r <2 pix=0.22") at 2 ? ~2?m can be obtained. In the cold optics, the drive systems with backlash-less gears are employed and work well even in cryogenic environment. The grisms made with silicon and germanium have been fabricated by ultraprecision cutting. It was found that their surface roughness, grating constant, and blaze angle almost measure up to the designed values.

Kamizuka, Takafumi; Miyata, Takashi; Sako, Shigeyuki; Nakamura, Tomohiko; Asano, Kentaro; Uchiyama, Mizuho; Okada, Kazushi; Onaka, Takashi; Sakon, Itsuki; Kataza, Hirokazu; Sarugaku, Yuki; Yoshii, Yuzuru; Doi, Mamoru; Kohno, Kotaro; Kawara, Kimiaki; Tanaka, Masuo; Motohara, Kentaro; Tanabe, Toshihiko; Minezaki, Takeo; Morokuma, Tomoki; Tamura, Yoichi; Aoki, Tsutomu; Soyano, Takao; Tarusawa, Ken'ichi; Kato, Natsuko; Konishi, Masahiro; Takahashi, Hidenori; Koshida, Shintaro; Tateuchi, Ken; Handa, Toshihiro

2012-09-01

106

Ta-O (Ta-oxide) and Nb-O (Nb-oxide) Film Deposition Using an Electron Cyclotron Resonance Plasma  

NASA Astrophysics Data System (ADS)

The low temperature depositions (under 200°C) of Ta-O and Nb-O films are investigated using microwave ECR (electron cyclotron resonance) plasma deposition with Ta-halide or Nb-halide and O2 as raw material gases. High deposition rate (400 Å/min) is easily obtained with Ta-chloride and Nb-chloride, however, with Ta-fluoride and Nb-fluoride the deposited films at 200 Å/min have low resistance against humidity due to their fluoride content. The refractive indices of the Ta-O and Nb-O are 2.15 and 2.2 at 6328 Å. The structures of both films are amorphous. They are stable up to 400°C.

Watanabe, Iwao; Yoshihara, Hideo

1985-06-01

107

Spred1 and TESK1Two New Interaction Partners of the Kinase MARKK\\/TAO1 That Link the Microtubule and Actin Cytoskeleton  

Microsoft Academic Search

ABSTRACT The signaling from MARKK\\/TAO1 to MARK\\/Par1 to phosphorylated MAPs renders microtubules dynamic,and plays a role in neurite outgrowth or polarity development. Since hyperphosphorylation of Tau at,MARK target sites is a hallmark of Alzheimer neurodegeneration we ,searched ,for upstream ,regulators by the ,yeast two-hybrid approach and identified two new interaction partners of MARKK, the regulator protein Spred1 and the kinase

Cindy Johne; Dorthe Matenia; Xiao-yu Li; Thomas Timm; Kiruthiga Balusamy; Eva-Maria Mandelkow

2008-01-01

108

Interactive web access to real-time El Nino\\/La Nina data from the TAO buoy network in the tropical Pacific  

Microsoft Academic Search

The TAO array consists of approximately 70 ATLAS and current meter moorings spanning the Equatorial Pacific from 95°W to 137°E in the west, telemetering oceanographic and meteorological data in real-time via the Argos satellite system. The purpose of the array is to provide high quality, in-situ, real-time data in the Equatorial Pacific Ocean for short-term climate studies, most notably those

W. H. Zhu; E. F. Burger; D. C. McClurg; D. W. Denbol; N. N. Soreide

1999-01-01

109

Preliminary geologic map of the Big Costilla Peak area, Taos County, New Mexico, and Costilla County, Colorado  

USGS Publications Warehouse

This map covers the Big Costilla Peak, New Mex.&nash;Colo. quadrangle and adjacent parts of three other 7.5 minute quadrangles: Amalia, New Mex.–Colo., Latir Peak, New Mex., and Comanche Point, New Mex. The study area is in the southwesternmost part of that segment of the Sangre de Cristo Mountains known as the Culebra Range; the Taos Range segment lies to the southwest of Costilla Creek and its tributary, Comanche Creek. The map area extends over all but the northernmost part of the Big Costilla horst, a late Cenozoic uplift of Proterozoic (1.7-Ga and less than 1.4-Ga) rocks that is largely surrounded by down-faulted middle to late Cenozoic (about 40 Ma to about 1 Ma) rocks exposed at significantly lower elevations. This horst is bounded on the northwest side by the San Pedro horst and Culebra graben, on the northeast and east sides by the Devils Park graben, and on the southwest side by the (about 30 Ma to about 25 Ma) Latir volcanic field. The area of this volcanic field, at the north end of the Taos Range, has undergone significantly greater extension than the area to the north of Costilla Creek. The horsts and grabens discussed above are all peripheral structures on the eastern flank of the San Luis basin, which is the axial part of the (about 26 Ma to present) Rio Grande rift at the latitude of the map. The Raton Basin lies to the east of the Culebra segment of the Sangre de Cristo Mountains. This foreland basin formed during, and is related to, the original uplift of the Sangre de Cristo Mountains which was driven by tectonic contraction of the Laramide (about 70 Ma to about 40 Ma) orogeny. Renewed uplift and structural modification of these mountains has occurred during formation of the Rio Grande rift. Surficial deposits in the study area include alluvial, mass-movement, and glacial deposits of middle Pleistocene to Holocene age.

Fridrich, Christopher J.; Shroba, Ralph R.; Hudson, Adam M.

2012-01-01

110

A stimulatory TSH receptor antibody enhances adipogenesis via phosphoinositide 3-kinase activation in orbital preadipocytes from patients with Graves' ophthalmopathy  

PubMed Central

Graves' ophthalmopathy (GO) is characterized by expanded volume of the orbital tissues associated with elevated serum levels of TSH receptor (TSHR) autoantibodies. Because previous studies have demonstrated evidence of adipogenesis within the GO orbit, we sought to determine whether M22, a human monoclonal antibody directed against TSHR, enhances adipogenesis in orbital fibroblasts from patients with GO and, if so, to identify signaling mechanisms involved. GO orbital fibroblast cultures (n=10) were treated for 10 days with bovine TSH (1 or 10·0?U/l) or M22 (1 or 10?ng/ml) in serum-free adipocyte differentiation medium. Some cultures also received a phosphoinositide 3-kinase (PI3K) inhibitor or an inhibitor of cAMP production. In other experiments, confluent cultures (n=8) were treated for between 1 and 30?min with TSH (0·1–10·0?U/l) or M22 (0·1–100?ng/ml) with measurement of cAMP production or levels of phosphorylated AKT (pAKT). We found levels of adiponectin, leptin, and TSHR mRNA to be increased in GO cultures treated for 10 days with either M22 (2·6 mean fold ±0·7; P=0·03) or TSH (13·2±5·8-fold, P=0·048). In other studies, M22 and TSH stimulated cAMP production and pAKT levels in GO cells. Inhibition of PI3K activity during 10 days in culture decreased the levels of M22-stimulated mRNA encoding adiponectin (67±12%; P=0·021), as well as adiponectin and CCAAT/enhancer-binding protein ? protein levels. In conclusion, M22 is a pro-adipogenic factor in GO orbital preadipocytes. This antibody appears to act via the PI3K signaling cascade, suggesting that inhibition of PI3K signaling may represent a potential novel therapeutic approach in GO.

Kumar, Seema; Nadeem, Sarah; Stan, Marius N; Coenen, Michael; Bahn, Rebecca S

2011-01-01

111

A genomic point mutation in the extracellular domain of the thyrotropin receptor in patients with Graves` ophthalmopathy  

SciTech Connect

Orbital and pretibial fibroblasts are targets of autoimmune attack in Graves` ophthalmopathy (GO) and pretibial dermopathy (PTD). The fibroblast autoantigen involved in these peripheral manifestations of Graves` disease and the reason for the association of GO and PTD with hyperthyroidism are unknown. RNA encoding the full-length extracellular domain of the TSH receptor has been demonstrated in orbital and dermal fibroblasts from patients with GO and normal subjects, suggesting a possible antigenic link between fibroblasts and thyrocytes. RNA was isolated from cultured orbital, pretibial, and abdominal fibroblasts obtained from patients with severe GO (n = 22) and normal subjects (n = 5). RNA was reverse transcribed, and the resulting cDNA was amplified by the polymerase chain reaction, using primers spanning overlapping regions of the entire extracellular domain of the TSH receptor. Nucleotide sequence analysis showed an A for C substitution in the first position of codon 52 in 2 of the patients, both of whom had GO, PTD, and acropachy. Genomic DNA isolated from the 2 affected patients, and not from an additional 12 normal subjects, revealed the codon 52 mutation by direct sequencing and AciI restriction enzyme digestions. In conclusion, the authors have demonstrated the presence of a genomic point mutation, leading to a threonine for proline amino acid shift in the predicted peptide, in the extracellular domain of the TSH receptor in two patients with severe GO, PTD, acropachy, and high thyroid-stimulating immunoglobulin levels. RNA encoding this mutant product was demonstrated in the fibroblasts of these patients. They suggest that the TSH receptor may be an important fibroblast autoantigen in GO and PTD, and that this mutant form of the receptor may have unique immunogenic properties. 28 refs., 3 figs., 2 tabs.

Bahn, R.S.; Dutton, C.M.; Heufelder, A.E.; Sarkar, G. [Mayo Clinic/Foundation, Rochester, MN (United States)]|[Ludwig-Maximilians-Universitat, Munich (Germany)

1994-02-01

112

Genetic Profiling in Graves' Disease: Further Evidence for Lack of a Distinct Genetic Contribution to Graves' Ophthalmopathy  

PubMed Central

Background Graves' disease (GD), including Graves' ophthalmopathy or orbitopathy (GO), is an autoimmune disease with an environmental and genetic component to its etiology. The genetic contribution to the GO clinical phenotype remains unclear. Previous data from our laboratory and others have suggested that GO has no specific genetic component distinct from GD itself, while other reports have occasionally appeared suggesting that polymorphisms in genes such as CTLA4 and IL23R specifically increase the risk for GO. One of the criticisms of all these reports has been the clinical definition of the GO phenotype as distinct from hyperthyroid GD devoid of clinically significant eye involvement. The objective of this study was to take advantage of a phenotypically pure group of GD patients with GO and examine a series of genes associated with GD to determine if any were more definitively associated with GO rather than Graves' thyroid disease itself. Methods To further examine whether specific susceptibility genes are associated with GO, we have performed further genetic association studies using highly characterized GO patients, many of whom had undergone orbital decompression surgery for their exophthalmos. We genotyped HLA, CTLA4, IL23R, and TSHR genes in a group of 256 Caucasian patients with severe GO (n=199) and less severe GO (n=57), and 90 patients with GD but no clinically apparent GO. Results We found that the allele and genotype frequencies were not statistically different between GO and non-GO patients for any of the genes and gene combinations assessed. Conclusions These results provide further evidence that patients with GO do not have a distinct genetic susceptibility to their eye disease and again suggest that environmental and/or epigenetic influences are at play.

Latif, Rauf; Bahn, Rebecca; Davies, Terry F.

2012-01-01

113

Comparative analysis of dosimetric parameters of three different radiation techniques for patients with Graves' ophthalmopathy treated with retro-orbital irradiation  

PubMed Central

Background We would like to investigate the if IMRT produced better target coverage and dose sparing to adjacent normal structures as compared with 3-dimensional conformal radiotherapy (3DCRT) and lateral opposing fields (LOF) for patients with Graves’ ophthalmopathy treated with retro-orbital irradiation. Methods Ten consecutive patients diagnosed with Graves’ ophthalmopathy were prospectively recruited into this study. An individual IMRT, 3DCRT and LOF plan was created for each patient. Conformity index (CI), homogeneity index (HI) and other dosimetric parameters of the targets and organs-at-risk (OAR) generated by IMRT were compared with the other two techniques. Results Mann–Whitney U test demonstrated that CI generated by IMRT was superior to that produced by 3DCRT and LOF (p=0.005 for both respectively). Similarly HI with IMRT was proven better than 3DCRT (p=0.007) and LOF (p=0.005). IMRT gave rise to better dose sparing to some OARs including globes, lenses and optic nerves as compared with 3DCRT but not with LOF. Conclusions IMRT, as compared with 3DCRT and LOF, was found to have a better target coverage, conformity and homogeneity and dose sparing to some surrounding structures, despite a slight increase but clinically negligible dose to other structures. Dosimetrically it might be a preferred treatment technique and a longer follow up is warranted to establish its role in routine clinical use.

2012-01-01

114

Electronic and optical properties of TaO1-xN1+x-based alloys  

NASA Astrophysics Data System (ADS)

TaON is considered as a potential candidate as a visible-light responsive photocatalyst. We report the results of ab initio studies of electronic structure of TaON-based alloys. Specifically, we show that the position of conduction and valence band can be modified by varying the oxygen and nitrogen concentrations in TaO1-xN1+x. We find that the band gap decreases monotonically with the increase of N/O ratio. The band gap energy is decreased in monoclinic TaON from near 2.3 eV to just over 1.7 eV (i.e., by 35%) when N/O ratio is increased from 3/5 to 5/3. Our calculations show that the band gap reduces in a series of experimentally fabricated alloys ZrTa3O5N3?TaON?YTa7O7N8. The band gap reduction is mostly associated with the change in the position of the valence band due to the hybridization of N 2p states, while the conduction band consisting mostly of Ta 5d-states is not sensitive to N content. The calculated optical absorption spectra show reduction in the optical band gap with increasing N/O ratio.

Al-Aqtash, Nabil; Apostol, Florin; Mei, Wai-Ning; Sabirianov, Renat F.

2013-02-01

115

Thyrotropin Regulates IL-6 Expression in CD34+ Fibrocytes: Clear Delineation of Its cAMP-Independent Actions  

PubMed Central

IL-6 plays diverse roles in normal and disease-associated immunity such as that associated with Graves’ disease (GD). In that syndrome, the orbit undergoes remodeling during a process known as thyroid-associated ophthalmopathy (TAO). Recently, CD34+ fibrocytes were found to infiltrate the orbit in TAO where they transition into CD34+ orbital fibroblasts. Surprisingly, fibrocytes display high levels of functional thyrotropin receptor (TSHR), the central antigen in GD. We report here that TSH and the pathogenic anti-TSHR antibodies that drive hyperthyroidism in GD induce IL-6 expression in fibrocytes and orbital fibroblasts. Unlike TSHR signaling in thyroid epithelium, that occurring in fibrocytes is completely independent of adenylate cyclase activation and cAMP generation. Instead TSH activates PDK1 and both AKT/PKB and PKC pathways. Expression and use of PKC?II switches to that of PKCµ as fibrocytes transition to TAO orbital fibroblasts. This shift is imposed by CD34? orbital fibroblasts but reverts when CD34+ fibroblasts are isolated. The up-regulation of IL-6 by TSH results from coordinately enhanced IL-6 gene promoter activity and increased IL-6 mRNA stability. TSH-dependent IL-6 expression requires activity at both CREB (?213 to ?208 nt) and NF-?B (–78 to ?62 nt) binding sites. These results provide novel insights into the molecular action of TSH and signaling downstream for TSHR in non-thyroid cells. Fibrocytes neither express adenylate cyclase nor generate cAMP and thus these findings are free from any influence of cAMP-related signaling. They identify potential therapeutic targets for TAO.

Raychaudhuri, Nupur; Fernando, Roshini; Smith, Terry J.

2013-01-01

116

Thyrotropin Regulates IL-6 Expression in CD34(+) Fibrocytes: Clear Delineation of Its cAMP-Independent Actions.  

PubMed

IL-6 plays diverse roles in normal and disease-associated immunity such as that associated with Graves' disease (GD). In that syndrome, the orbit undergoes remodeling during a process known as thyroid-associated ophthalmopathy (TAO). Recently, CD34(+) fibrocytes were found to infiltrate the orbit in TAO where they transition into CD34(+) orbital fibroblasts. Surprisingly, fibrocytes display high levels of functional thyrotropin receptor (TSHR), the central antigen in GD. We report here that TSH and the pathogenic anti-TSHR antibodies that drive hyperthyroidism in GD induce IL-6 expression in fibrocytes and orbital fibroblasts. Unlike TSHR signaling in thyroid epithelium, that occurring in fibrocytes is completely independent of adenylate cyclase activation and cAMP generation. Instead TSH activates PDK1 and both AKT/PKB and PKC pathways. Expression and use of PKC?II switches to that of PKCµ as fibrocytes transition to TAO orbital fibroblasts. This shift is imposed by CD34(-) orbital fibroblasts but reverts when CD34(+) fibroblasts are isolated. The up-regulation of IL-6 by TSH results from coordinately enhanced IL-6 gene promoter activity and increased IL-6 mRNA stability. TSH-dependent IL-6 expression requires activity at both CREB (-213 to -208 nt) and NF-?B (-78 to -62 nt) binding sites. These results provide novel insights into the molecular action of TSH and signaling downstream for TSHR in non-thyroid cells. Fibrocytes neither express adenylate cyclase nor generate cAMP and thus these findings are free from any influence of cAMP-related signaling. They identify potential therapeutic targets for TAO. PMID:24086448

Raychaudhuri, Nupur; Fernando, Roshini; Smith, Terry J

2013-09-25

117

The epidemiologic characteristics and clinical course of ophthalmopathy associated with autoimmune thyroid disease in Olmsted County, Minnesota.  

PubMed Central

Among incident cases of GO in Olmsted County, Minnesota: GO affected females six times more frequently than males (86% versus 14% of cases, respectively). The age-adjusted incidence rate was 16 cases per 100,000 population per year for females and 2.9 cases per 100,000 population for males. The peak incidence rates were bimodal, occurring in the age groups 40 to 44 years and 60 to 64 years in females and 45 to 49 years and 65 to 69 years in males. Among patients with GO, approximately 90% had Graves' hyperthyroidism, 1% had primary hypothyroidism, 3% had Hashimoto's thyroiditis, and 5% were euthyroid. Eyelid retraction was the most common ophthalmic feature of autoimmune thyroid disease, being present either unilaterally or bilaterally in more than 90% of patients at some point in their clinical course. Exophthalmos of one or both eyes affected approximately 60% of patients, restrictive extraocular myopathy was apparent in about 40% of patients, and optic nerve dysfunction occurred in either one or both eyes in 6% of patients with autoimmune thyroid disease. Only 5% of patients had the complete constellation of classic findings: eyelid retraction, exophthalmos, optic nerve dysfunction, extraocular muscle involvement, and hyperthyroidism. Upper eyelid retraction, either unilateral or bilateral, was documented in approximately 75% of patients at the time of diagnosis of GO. Lid lag also was a frequent early sign, being present either unilaterally or bilaterally in 50% of patients at the initial examination. At the time of diagnosis of GO, the most frequent ocular symptom was pain or discomfort, which affected 30% of patients. Some degree of diplopia was noted by approximately 17% of patients, lacrimation or photophobia was present in about 15% to 20% of patients, and 7.5% of patients complained of blurred vision. Decreased vision attributable to optic neuropathy was present in less than 2% of eyes at the time of diagnosis of GO. Thyroid dermopathy and acropachy accompanied GO in approximately 4% and 1% of patients, respectively. Myasthenia gravis occurred in less than 1% of patients. Superior limbic keratoconjunctivitis was documented in less than 4% of patients. The median age at the time of diagnosis of GO was 43 years (range, 8 to 88). Among patients with hyperthyroidism, 61% developed ophthalmopathy within 1 year of the onset of thyrotoxicosis. Symptoms and signs for which statistically significant changes occurred between the initial and final examinations included lacrimation, pain or ocular discomfort, photophobia, eyelid retraction, lid lag, eyelid fullness, conjunctival injection, chemosis, and exophthalmos.(ABSTRACT TRUNCATED AT 400 WORDS) Images FIGURE 1 FIGURE 2 FIGURE 3

Bartley, G B

1994-01-01

118

Conundrums in the legal protection of migrant workers' health rights and relative resolutions: implications from the case of Tseng Hei-tao.  

PubMed

The deteriorating situation of migrant workers' health rights protection was once again highlighted in the case of Tseng Hei-tao. This case explicitly and implicitly showed that four conundrums--the Employment Restriction Conundrum, the Occupational Safety and Health (OSH) Legal Conundrum, the Morality Conundrum and the Identity Conundrum--are barriers to migrant workers' right protection. The health rights of migrant workers could be safeguarded by abolishing the outdated household registration system designed in the planned economy era, improving the rule of law, and strengthening administrative supervisions. This would fundamentally remove these barriers and thus contribute to migrant workers' health rights protection. PMID:23073738

Liu, Kai

2013-08-01

119

American Association of Clinical Endocrinologists, Associazione Medici Endocrinologi, and European Thyroid Association medical guidelines for clinical practice for the diagnosis and management of thyroid nodules: Executive Summary of recommendations.  

PubMed

American Association of Clinical Endocrinologists, Associazione Medici Endocrinologi, and European Thyroid Association medical guidelines for clinical practice for the diagnosis and management of thyroid nodules are systematically developed statements to assist health care professionals in medical decision making for specific clinical conditions. Most of the content herein is based on literature reviews. In areas of uncertainty, professional judgment was applied. These guidelines are a working document that reflects the state of the field at the time of publication. Because rapid changes in this area are expected, periodic revisions are inevitable. We encourage medical professionals to use this information in conjunction with their best clinical judgment. Any decision by practitioners to apply these guidelines must be made in light of local resources and individual patient circumstances. PMID:20479572

Gharib, H; Papini, E; Paschke, R; Duick, D S; Valcavi, R; Hegedüs, L; Vitti, P

2010-05-17

120

American Association of Clinical Endocrinologists, Associazione Medici Endocrinologi, and European Thyroid Association medical guidelines for clinical practice for the diagnosis and management of thyroid nodules: executive summary of recommendations.  

PubMed

American Association of Clinical Endocrinologists, Associazione Medici Endocrinologi, and European Thyroid Association medical guidelines for clinical practice for the diagnosis and management of thyroid nodules are systematically developed statements to assist health care professionals in medical decision making for specific clinical conditions. Most of the content herein is based on literature reviews. In areas of uncertainty, professional judgment was applied. These guidelines are a working document that reflects the state of the field at the time of publication. Because rapid changes in this area are expected, periodic revisions are inevitable. We encourage medical professionals to use this information in conjunction with their best clinical judgment. Any decision by practitioners to apply these guidelines must be made in light of local resources and individual patient circumstances. PMID:20543551

Gharib, H; Papini, E; Paschke, R; Duick, D S; Valcavi, R; Hegedüs, L; Vitti, P

2010-01-01

121

American Association of Clinical Endocrinologists, Associazione Medici Endocrinologi, and European Thyroid Association Medical guidelines for clinical practice for the diagnosis and management of thyroid nodules: executive summary of recommendations.  

PubMed

American Association of Clinical Endocrinologists, Associazione Medici Endocrinologi, and European Thyroid Association Medical Guidelines for Clinical Practice for the Diagnosis and Management of Thyroid Nodules are systematically developed statements to assist health care professionals in medical decision making for specific clinical conditions. Most of the content herein is based on literature reviews. In areas of uncertainty, professional judgment was applied.These guidelines are a working document that reflects the state of the field at the time of publication. Because rapid changes in this area are expected, periodic revisions are inevitable. We encourage medical professionals to use this information in conjunction with their best clinical judgment. Any decision by practitioners to apply these guidelines must be made in light of local resources and individual patient circumstances. PMID:20551008

Gharib, Hossein; Papini, Enrico; Paschke, Ralf; Duick, Daniel S; Valcavi, Roberto; Hegedüs, Laszlo; Vitti, Paolo

122

Electrochemical oxidation of tannic acid contaminated wastewater by RuO2/IrO2/TaO2-coated titanium and graphite anodes.  

PubMed

The electrochemical oxidation of tannic acid contaminated wastewater by RuO2/IrO2/TaO2-coated titanium and graphite anodes has been investigated. The effect of the process variables, such as initial pH, current density, processing time, concentration of the electrolyte and anode materials, on the degradation of tannic acid was studied. During the various stages of electrolysis, parameters such as COD, chloride ion concentration and UV-Vis spectra were examined and discussed. The maximum chemical oxygen demand (COD) removal efficiency of 94% was achieved at pH 5, operated at the current density of 8.10 mA/cm2, electrolyte (NaCl) concentration of 0.1 M and at 60 min of electrolysis using graphite anodes. The experimental results showed that the electrochemical oxidation process could effectively reduce the COD from the tannic acid contaminated wastewater. An acidic pH showed the maximum reduction of COD compared with neutral and alkaline pH. Increase in current density, process time and electrolyte (NaCl) concentration with the increase in COD removal. Graphite anodes showed maximum removal of COD and better tannic acid degradation when compared with RuO2/IrO2/TaO2-coated titanium anodes. PMID:21275257

Govindaraj, M; Muthukumar, M; Raju, G Bhaskar

2010-12-14

123

Digital data and derivative products from a high-resolution aeromagnetic survey of the central San Luis basin, covering parts of Alamosa, Conejos, Costilla, and Rio Grande counties, Colorado, and Taos county, New Mexico  

USGS Publications Warehouse

This report describes data collected from a high-resolution aeromagnetic survey flown over the central San Luis basin during October, 2004, by PRJ, Inc., on contract to the U.S. Geological Survey (USGS). The survey extends from just north of Alamosa, Colorado, southward to just northwest of Taos, New Mexico. It covers large parts of the San Luis Valley in Alamosa, Conejos, Costilla, and Rio Grande Counties, southern Colorado, and the Taos Plateau in Taos County, northern New Mexico. The survey was designed to complement two surveys previously acquired along the eastern borders of the San Luis Basin over the vicinities of Taos, New Mexico (Bankey and others, 2004a) and Blanca, Colorado (Bankey and others, 2004b). Our overall objective in conducting these surveys is to improve knowledge of the subsurface geologic framework in order to understand ground-water systems in populated alluvial basins along the Rio Grande. These USGS efforts are conducted in collaboration with other federal, state, and local governmental entities where possible.

Bankey, Viki; Grauch, V. J. S.; Webbers, Ank; PRJ, Inc.

2005-01-01

124

An assessment of equatorial variability and surface currents in FOAM-NEMO against observations, including the TAO Array  

NASA Astrophysics Data System (ADS)

The Met Office run daily analyses and 5 day forecasts using several operational configurations of the Forecast Ocean Assimilation Model (FOAM) system, using the NEMO ocean and LIM2 sea ice models. These configurations include the ¼ degree global (ORCA025); the 1/12th degree regional North Atlantic; the 1/12th degree regional Indian Ocean; and the 1/12th degree regional Mediterranean domains. Hindcast analyses of all these operational configurations have been run for the period 2007 to 2008, both with and without data assimilation. Mean model drifts were estimated from the difference between the 2008 annual means for the assimilative and free runs. Qualitative assessment of simulated equatorial sea surface height between the AVISO observations and the assimilative global model indicated good agreement. In the free running global model there was a drift in sea surface height associated with a global freshwater imbalance. However, when this drift was removed the simulated sea surface height agreed reasonably well both with the observations and with the assimilative model. Qualitative assessment of simulated equatorial SST against the OSTIA observational analysis also indicated good agreement. Assessment of the simulated Pacific equatorial zonal flows with data assimilation against observations also indicated reasonably qualitative agreement. Surface currents were assessed quantitatively against observations at ~45 TAO Array moorings for the Global and Indian Ocean models through visual inspection, correlation, several cost functions, RMS, mean errors, Taylor diagrams etc. Visual inspection suggested that zonal (u) currents are less challenging to model accurately than the meridional flows (v) due to their lower variability and consistent direction. They also confirmed that there is considerable variability in model skill between individual locations, over the two year period. The overall global equatorial quantitative assessment suggest that the assimilative global model had good skill (r=0.77) for zonal currents but poor skill (r=0.46) for meridional currents. By comparison, the non-assimilative global model had average skill (r=0.67) for zonal flows but poor skill (r=0.36) for meridional flows. In both runs, a band of negative mean bias of the order of 20cm/s is evident along the equator in all ocean. For both global model runs, skills (defined in terms of r) appeared to be highest in the Indian Ocean (assimilative model u and v, r values of 0.77 and 0.63, respectively), medium in the Pacific Ocean (assimilative model u and v, r values of 0.78 and 0.43, respectively) and lowest in the Atlantic Ocean (assimilative model u and v, r values of 0.58 and 0.33, respectively). In the Indian Ocean region, for the global assimilative ocean model correlations for u and v, respectively were good (r=0.77) and average (r=0.63) whilst for the non-assimilative model they were also good (r=0.73) and average (r=0.66). The regional 1/12th degree Indian Ocean model had similar skill to the global ¼ degree ocean model at simulating equatorial currents, i.e. no additional skill was evident for the higher resolution model.

Hyder, Patrick; Storkey, Dave; Blockley, Ed; Guiavarc'h, Catherine; Siddorn, John; Barciela, Rosa

2010-05-01

125

A second mutation in the type II procollagen gene (COL2AI) causing stickler syndrome (arthro-ophthalmopathy) is also a premature termination codon.  

PubMed Central

Genetic linkage analyses suggest that mutations in type II collagen may be responsible for Stickler syndrome, or arthro-ophthalmopathy (AO), in many families. In the present study oligonucleotide primers were developed to amplify and directly sequence eight of the first nine exons of the gene for type II procollagen (COL2A1). Analysis of the eight exons in 10 unrelated probands with AO revealed that one had a single-base mutation in one allele that changed the codon of -CGA- for arginine at amino acid position alpha 1-9 in exon 7 to a premature termination signal for translation. The second mutation found to cause AO was, therefore, similar to the first in that both created premature termination signals in the COL2A1 gene. Since mutations producing premature termination signals have not previously been detected in genes for fibrillar collagens, the results raise the possibility that such mutations in the COL2A1 gene are a common cause of AO. Images Figure 2 Figure 3

Ahmad, N N; McDonald-McGinn, D M; Zackai, E H; Knowlton, R G; LaRossa, D; DiMascio, J; Prockop, D J

1993-01-01

126

Pliocene volcanism of the Taos Plateau, Rio Grande Rift-New constraints on eruptive cycles, compositional trends and links to rift tectonism  

NASA Astrophysics Data System (ADS)

The Taos Plateau volcanic field (TPVF) in the southern San Luis Basin of northern New Mexico and southern Colorado is the most voluminous of the predominantly basaltic Neogene (6-1 Ma) volcanic fields of the Rio Grande rift. Coincident with extensional tectonism, volcanic deposits of the TPVF are intercalated with alluvial deposits of the Santa Fe Group and reflect the time-integrated magmatic response to basin- and sub basin-scale structural accommodation of regional extension. New data constraining the eruptive history of mafic to intermediate composition Pliocene volcanic rocks of the Taos Plateau volcanic field are presented based on integrated geologic mapping (1:24,000 to 1:50,000 scale), 40Ar/39Ar geochronology, geochemistry and aeromagnetic data. Mapped stratigraphy and faulting is linked to new gravity model interpretations to establish the location of deeper basin and sub basin geometry relative to mapped eruptive centers. Three representative clusters of eruptive centers in the San Luis Basin (San Antonio Mtn., Ute Mtn., and Guadalupe Mtn./Red River areas) range in composition from basaltic andesite to dacite but are volumetrically dominated by high-silica andesite to dacite. Eruptive cycles for each cluster are: San Antonio Mtn. (andesite - 4.17 Ma, high silica andesite to dacite - 3.08 Ma); Ute Mtn. (andesite - 3.95 Ma, high silica andesite - 3.90 Ma); Guadalupe Mtn./Red River (Guadalupe Mtn. dacite - 5.04 Ma, Hatchery volcano basaltic andesite to andesite - 4.90 Ma) and Red River high silica andesite - 4.64 Ma). Deposits of each cluster are stratigraphically intercalated with Servilleta Basalt (5.26-3.36 Ma) but not temporally associated with these distally derived lavas. Each mapped cluster is spatially associated with mapped or inferred basin- or sub basin- bounding structures largely derived from new gravity models and interpretation of aeromagnetic data. However, few temporal constraints on pre- as well as post-eruption displacement on rift faults are observed. Mapped eruptive centers are interpreted to reflect; 1) discrete pulses of volcanic activity characterized by limited compositional range, 2) relatively short life cycles and, 3) spatial association with known faults or inferred basin boundaries. The latter may result from coupled partitioning of extensional strain reflected as local expressions of sub basin development and contemporaneous volcanism.

Thompson, R. A.; Cosca, M. A.; Turner, K. J.; Condit, C. B.; Lee, J.; Budahn, J. R.; Drenth, B.

2011-12-01

127

Preliminary Geologic Map of the Vermejo Peak area, Colfax and Taos Counties, New Mexico and Las Animas and Costilla Counties, Colorado  

USGS Publications Warehouse

This geologic map covers four 7.5-minute quadrangles-The Wall, NM-CO (New Mexico-Colorado), Vermejo Park, NM-CO, Ash Mountain, NM, and Van Bremmer Park, NM. The study area straddles the boundary between the eastern flank of the Sangre de Cristo Mountains and the western margin of the Raton Basin, with about two-thirds of the map area in the basin. The Raton Basin is a foreland basin that formed immediately eastward of the Sangre de Cristo Mountains during their initial uplift, in the Late Cretaceous through early Eocene Laramide orogeny. Subsequently, these mountains have been extensively modified during formation of the Rio Grande rift, from late Oligocene to present. The map area is within that part of the Sangre de Cristo Mountains that is called the Culebra Range. Additionally, the map covers small parts of the Devil's Park graben and the Valle Vidal half-graben, in the northwestern and southwestern parts of the map area, respectively. These two grabens are small intermontaine basins, that are satellitic to the main local basin of the Rio Grande rift, the San Luis Basin, that are an outlying, early- formed part of the rift, and that separate the Culebra Range from the Taos Range, to the southwest.

Fridrich, Christopher J.; Shroba, Ralph R.; Pillmore, Charles L.; Hudson, Adam M.

2009-01-01

128

Serum Containing Tao-Hong-Si-Wu Decoction Induces Human Endothelial Cell VEGF Production via PI3K/Akt-eNOS Signaling  

PubMed Central

Tao-Hong-Si-Wu decoction (TSD) is a famous traditional Chinese medicine (TCM) and widely used for ischemic disease in China. TSD medicated serum was prepared after oral administration of TSD (1.6?g/kg) twice a day for 3 days in rats. TSD medicated serum induced human umbilical vein endothelial cells (HUVECs) proliferation, VEGF secretion, and nitric oxide (NO) production. These promoted effects of TSD were partly inhibited by treatment with PI3K inhibitor (LY294002) or eNOS inhibitor (L-NAME), respectively, and completely inhibited by treatment with LY294002 and L-NAME simultaneously. Western blot analysis findings further indicated that TSD medicated serum upregulated p-Akt and p-eNOS expressions, which were significantly inhibited by LY294002 or L-NAME and completely inhibited by both LY294002 and L-NAME; these results indicated that TSD medicated serum induced HUVECs VEGF expression via PI3K/Akt-eNOS signaling. TSD medicated serum contains hydroxysafflor yellow A, ferulic acid, and ligustilide detected by UPLC with standards, so these effect of TSD medicated serum may be associated with these three active compounds absorbed in serum.

Yin, DengKe; Liu, ZhuQing; Peng, DaiYin; Yang, Ye; Gao, XiangDong; Xu, Fan; Han, Lan

2013-01-01

129

Spred1 and TESK1--Two New Interaction Partners of the Kinase MARKK/TAO1 That Link the Microtubule and Actin Cytoskeleton  

PubMed Central

The signaling from MARKK/TAO1 to the MAP/microtubule affinity-regulating kinase MARK/Par1 to phosphorylated microtubule associated proteins (MAPs) renders microtubules dynamic and plays a role in neurite outgrowth or polarity development. Because hyperphosphorylation of Tau at MARK target sites is a hallmark of Alzheimer neurodegeneration, we searched for upstream regulators by the yeast two-hybrid approach and identified two new interaction partners of MARKK, the regulatory Sprouty-related protein with EVH-1 domain1 (Spred1) and the testis-specific protein kinase (TESK1). Spred1-MARKK binding has no effect on the activity of MARKK; therefore, it does not change microtubule (MT) stability. Spred1-TESK1 binding causes inhibition of TESK1. Because TESK1 can phosphorylate cofilin and thus stabilizes F-actin stress fibers, the inhibition of TESK1 by Spred1 makes F-actin fibers dynamic. A third element in this interaction triangle is that TESK1 binds to and inhibits MARKK. Thus, in Chinese hamster ovary (CHO) cells the elevation of MARKK results in MT disruption (via activation of MARK/Par1 and phosphorylation of MAPs), but this can be blocked by TESK1. Similarly, enhanced TESK1 activity results in increased stress fibers (via phospho-cofilin), but this can be blocked by elevating Spred1. Thus, the three-way interaction between Spred1, MARKK, and TESK1 represents a pathway that links regulation of both the microtubule- and F-actin cytoskeleton.

Johne, Cindy; Matenia, Dorthe; Li, Xiao-yu; Timm, Thomas; Balusamy, Kiruthiga

2008-01-01

130

A case study of the tropical Hot Event in November 2006 (HE0611) using a geostationary meteorological satellite and the TAO/TRITON mooring array  

NASA Astrophysics Data System (ADS)

Qin et al. have found Hot Events (HE), which are short-term (about 20 days) large-scale (about 15,000,000 km2) regions with very high Sea Surface Temperatures (SST > 30°C). Following their definition, an HE was identified in the tropical western Pacific in November 2006, which is named HE0611. A case study of HE is conducted by using the advanced satellite products and in-situ measurements from the TAO/TRITON mooring array. Two parts (HE0611-East and -West) with very high SST connected to form HE0611. SST in HE0611-West increases quickly with large diurnal SST variations, which are caused by large solar radiation and suppressed latent heat loss. The increase of the mixed-layer heat content is clearly accounted for the accumulated heat gain through the air-sea interaction. The formation mechanism of HE0611-East is completely different; its very high SST is supported by a subsurface high SST anomaly associated with the El Niño. Two phenomena similar to HE0611 were observed in November of the El Niño years of 1994 and 2002.

Qin, Huiling; Kawamura, Hiroshi; Sakaida, Futoki; Ando, Kentaro

2008-08-01

131

A case study of the tropical Hot Event in November 2006 (HE0611) using a geostationary meteorological satellite and the TAO/TRITON mooring array  

NASA Astrophysics Data System (ADS)

Qin et al. [2007] have found Hot Event (HE), which is a short-term (about 20 days) large-scale (about 15,000,000km2) region with very high Sea Surface Temperature (SST˜30o C). Following their definition, a HE was identified in the tropical western Pacific in November 2006, which is named HE0611. A case study of HE is conducted by using the advanced satellite products and in situ measurements from TAO/TRITON mooring array. Two parts (HE0611-East and -West) with very high SST did connected to form HE0611. SST in HE0611-West increases quickly with large diurnal SST variations, which are caused by large solar radiation and suppressed latent heat loss. Increase of the mixed-layer heat content is well explained by the accumulated heat gain through the air-sea interaction. The formation mechanism of HE0611-East is completely different; its very high SST is supported by sub-surface high SST anomaly associated with the El Nino. Two phenomena similar to HE0611 were observed in November of El N?o Years of n 1994 and 2002.

Qin, Huiling

132

American thyroid association statement on outpatient thyroidectomy.  

PubMed

Background: The primary goals of this interdisciplinary consensus statement are to define the eligibility criteria for outpatient thyroidectomy and to explore preoperative, intraoperative, and postoperative factors that should be considered in order to optimize the safe and efficient performance of ambulatory surgery. Summary: A series of criteria was developed that may represent relative contraindications to outpatient thyroidectomy, and these fell into the following broad categories: clinical, social, and procedural issues. Intraoperative factors that bear consideration are enumerated, and include choice of anesthesia, use of nerve monitoring, hemostasis, management of the parathyroid glands, wound closure, and extubation. Importantly, postoperative factors are described at length, including suggested discharge criteria and recognition of complications, especially bleeding, airway distress, and hypocalcemia. Conclusions: Outpatient thyroidectomy may be undertaken safely in a carefully selected patient population provided that certain precautionary measures are taken to maximize communication and minimize the likelihood of complications. PMID:23742254

Terris, David J; Snyder, Samuel; Carneiro-Pla, Denise; Inabnet, William B; Kandil, Emad; Orloff, Lisa; Shindo, Maisie; Tufano, Ralph P; Tuttle, R Michael; Urken, Mark; Yeh For The American Thyroid Association Surgical Affairs Committee Writing Task Force, Michael W

2013-09-14

133

Clinical outcomes of radiotherapy as initial local therapy for Graves' ophthalmopathy and predictors of the need for post-radiotherapy decompressive surgery  

PubMed Central

Background The optimal initial local treatment for patients with Graves’ ophthalmopathy (GO) is not fully characterized. The purpose of this retrospective study is to describe the clinical outcomes of RT as initial local therapy for GO and define predictors of the need for post-RT salvage bony decompressive surgery. Methods 91 patients with active GO and without prior surgery were treated with RT as initial local therapy between 01/1999 and 12/2010, with a median follow-up period of 18.3?months (range 3.7 - 142?months). RT dose was 24?Gy in 12 fractions. 44 patients (48.4%) had prior use of steroids, with 31 (34.1%) being on steroids at the initiation of RT. The most common presenting symptoms were diplopia (79%), proptosis (71%) and soft tissue signs (62%). Results 84 patients (92.3%) experienced stabilization or improvement of GO symptoms. 58 patients (64%) experienced improvement in their symptoms. 19 patients (20.9%) underwent salvage post-RT bony decompressive surgery. Smoking status and total symptom score at 4?months were independent predictors of post-RT bony decompression with odds ratios of 3.23 (95% CI 1.03 – 10.2) and 1.59 (95% CI 1.06 – 2.4), respectively. Persistent objective vision loss at 4?months post-RT was the most important symptom type in predicting salvage decompression. Chronic dry eye occurred in 9 patients (9.9%) and cataracts developed in 4 patients (4.4%). Conclusions RT is effective and well tolerated as initial local therapy for active GO, with only 21% of patients requiring decompressive surgery post RT. Most patients experience stabilization or improvement of GO symptoms, but moderate to significant response occurs in the minority of patients. Smoking status and total symptom severity at 4?months, primarily persistent objective vision loss, are the primary determinants of the need for post-RT salvage bony decompression. Patients who smoke or present with predominantly vision loss symptoms should be advised as to their lower likelihood of symptomatic response to RT and their increased likelihood of requiring post-RT decompressive surgery.

2012-01-01

134

Improved textured La2Zr2O7 buffer on La3TaO7 seed for all-MOD Buffer/YBCO coated conductors  

NASA Astrophysics Data System (ADS)

The overall purpose of this research is to develop a potentially low-cost, high throughput, high yield, manufacturing process for buffer deposition, and to gain a fundamental understanding of buffer layers required for an all metal-organic deposition (MOD) based chemical solution approach. This understanding is critical to the development of a reliable, robust, low-cost, long-length manufacturing process of 2G wires. The standard RABiTS architectures consists of a starting template of biaxially textured Ni W (5 at.%) substrate with a seed layer of Y2O3, a barrier layer of YSZ, and a CeO2 cap. In this three-layer architecture, all the buffers are deposited using reactive sputtering. We have recently demonstrated that the barrier properties and the performance of MOD La2Zr2O7 (LZO) match that of sputtered YSZ layers. In this work, the texture of MOD LZO was also improved by inserting a sputtered Y2O3 seed layer on which LZO grows without any degradation of texture. Significant improvement in the texture of sputtered Y2O3 seeds on NiW substrates is usually observed which is then transferred to the LZO layer. A key challenge for an all-solution approach is to replace the sputtered seed layer with a possible MOD seed layer with improved texture and on which no degradation of LZO texture occurs. Very recently, we have grown MOD La3TaO7 (LTO) seeds directly on biaxially textured Ni W (3 at.%) with improved texture. In this study, we report a systematic investigation of the growth MOD LZO barrier layer on MOD LTO seeds. Preliminary results show that it is possible to grow MOD LZO with improved texture on MOD LTO seeds. This approach could be potentially used for future all MOD buffer/YBCO coated conductors.

Parans Paranthaman, M.; Bhuiyan, M. S.; Sathyamurthy, S.; Heatherly, L.; Cantoni, C.; Goyal, A.

2008-09-01

135

TAO: how facebook serves the social graph  

Microsoft Academic Search

Over 800 million people around the world share their social interactions with friends on Facebook, providing a rich body of information referred to as the social graph. In this talk, I describe how we model and serve this graph. Our model uses typed nodes (fbobjects) and edges (associations) to express the relationships and actions that happen on Facebook. We access

Venkateshwaran Venkataramani; Zach Amsden; Nathan Bronson; George Cabrera III; Prasad Chakka; Peter Dimov; Hui Ding; Jack Ferris; Anthony Giardullo; Jeremy Hoon; Sachin Kulkarni; Nathan Lawrence; Mark Marchukov; Dmitri Petrov; Lovro Puzar

2012-01-01

136

Authentication in the Taos Operating System  

Microsoft Academic Search

We describe a design and implementation of security for a distributed system. In our system, applications access security services through a narrow interface. This interface provides a notion of identity that includes simple principals, groups, roles, and delegations. A new operating system component manages principals, credentials, and secure channels. It checks credentials according to the formal rules of a logic

Edward Wobber; Martín Abadi; Michael Burrows; Butler W. Lampson

1993-01-01

137

Authentication in the Taos operating system  

Microsoft Academic Search

We describe a design for security in a distributed system and its implementation. In our design, applications gain access to security services through a narrow interface. This interface provides a notion of identity that includes simple principals, groups, roles, and delegations. A new operating system component manages principals, credentials, and secure channels. It checks credentials according to the formal rules

Edward Wobber; Martín Abadi; Michael Burrows; Butler Lampson

1994-01-01

138

Immunohistochemical Studies Using Immunized Guinea Pig Sera with Features of Anti-Human Thyroid, Eye and Skeletal Antibody and Graves’ Sera  

Microsoft Academic Search

  Type 2 5? deiodinase enzyme was observed in both thyroid and eye muscle tissues, highlighting its possible role as a common\\u000a antigen in thyroid-associated ophthalmopathy. Sera of 105 Graves’ patients and 40 controls, and immunized guinea pig sera\\u000a against TCSS peptide, showing homology to the amino acid sequence from 132 to 152 of type 2 5? deiodinase, were investigated\\u000a to

IldikÓ MolnÁr; Zita Szombathy; Ilona KovÁcs; A. JÓZsef SzentmiklÓsi

2007-01-01

139

Investigation of the laser and optical properties of Nd3+:Ba(Zr, Mg, Ta)O3 ceramic, Nd3+(Na+):Ca2MgSi2O7 single crystal, and Yb3+:Lu3Al5O12 ceramic  

NASA Astrophysics Data System (ADS)

We report three new laser materials. Nd3+-doped Ba(Zr, Mg, Ta)O3 ceramic indicates a broadband luminescence spectrum due to its disordered structure. By optimizing the manufacturing process and laser configuration, high output power and high slope efficiency operation was obtained. Nd3+(Na+):Ca2MgSi2O7 shows another type of spectral broadening caused by its structural modulation. In the input-output property, an anomalous behavior due to phase transition was observed. Yb3+:Lu3Al5O12 is one of the important laser materials for thin-disk laser because it indicates mild reduction of the thermal conductivity as an increase of concentration. The highly efficient CW laser operation is reported.

Nakao, Hiroaki; Shirakawa, Akira; Ueda, Ken-ichi; Kaminskii, Alexander A.; Kuretake, Satoshi; Tanaka, Nobuhiko; Kintaka, Yuji; Kageyama, Keisuke; Yagi, Hideki; Yanagitani, Takagimi

2013-02-01

140

Taos Pueblo: an indigenous community holding on to Promethean values  

Microsoft Academic Search

Purpose – This paper aims to give an account – using photographs as well as words – to describe a North American indigenous community that is retaining pre-contact Promethean values. Design\\/methodology\\/approach – The paper adopts as its approach ethnographic literature and field interviews coupled with extensive photography. Findings – Entrepreneurship may be linked to Promethean values, a characteristic of Pueblo

Leo Paul Dana; Robert Brent Anderson

2007-01-01

141

Integrating an Intelligent Tutoring System for TAOs with Second Life.  

National Technical Information Service (NTIS)

The Tactical Action Officer on board a U.S. Navy Cruiser, Destroyer, or Frigate is responsible for the operation of the entire watch team manning the ship's command center. Responsibilities include tactical decision-making, console operation, communicatio...

A. Nguyen E. Remolina E. Sincoff J. Ludwig R. Stottler

2010-01-01

142

Tao of Special Forces: An Analysis of Counterinsurgency Doctrine.  

National Technical Information Service (NTIS)

The unwillingness to correct deficiencies in current COIN doctrine or to adhere to the effective methods outlined by count doctrine will lead to continued instability and possible failure of counterinsurgency operations and government in states with large...

D. T. Reed A. A. Donahoe

2004-01-01

143

75 FR 71414 - Questa Ranger District, Carson National Forest; Taos County, NM; Taos Ski Valley's 2010 Master...  

Federal Register 2010, 2011, 2012, 2013

...near the Adventure Center to supplement non-sliding winter activities. --Constructing a 3.6-mile, lift served mountain bike trail between the top of Lift 1 and the base area to provide alternative summer recreational activities. --Reconfiguring...

2010-11-23

144

Gallium-67 uptake by the thyroid associated with progressive systemic sclerosis  

SciTech Connect

Although thyroidal uptake of gallium-67 has been described in several thyroid disorders, gallium-67 scanning is not commonly used in the evaluation of thyroid disease. Thyroidal gallium-67 uptake has been reported to occur frequently with subacute thyroiditis, anaplastic thyroid carcinoma, and thyroid lymphoma, and occasionally with Hashimoto's thyroiditis and follicular thyroid carcinoma. A patient is described with progressive systemic sclerosis who, while being scanned for possible active pulmonary involvement, was found incidentally to have abnormal gallium-67 uptake only in the thyroid gland. Fine needle aspiration cytology of the thyroid revealed Hashimoto's thyroiditis. Although Hashimoto's thyroiditis occurs with increased frequency in patients with progressive systemic sclerosis, thyroidal uptake of gallium-67 associated with progressive systemic sclerosis has not, to our knowledge, been previously described. Since aggressive thyroid malignancies frequently are imaged by gallium-67 scintigraphy, fine needle aspiration cytology of the thyroid often is essential in the evaluation of thyroidal gallium-67 uptake.

Sjoberg, R.J.; Blue, P.W.; Kidd, G.S.

1989-01-01

145

Hashimoto's thyroiditis associated Evans syndrome: A rare case report on the clustered autoimmune disease triad.  

PubMed

Evans syndrome is a rare combination of autoimmune hemolytic anemia and immune thrombocytopenia. Their association with autoimmune thyroid diseases has been reported by few authors; however, a sequential development of the Evans syndrome in cases of Hashimoto's thyroiditis is extremely rare. The clustering of these autoimmune diseases might share a common pathogenic pathway. We present the fourth such case in world literature, of a 34-year-old female diagnosed with Hashimoto's thyroiditis in 2006, who has been taking synthetic thyroid hormone since then. Her condition is now clinically complicated with the development of the Evans syndrome. PMID:23961497

Koti, Kalyan; Thumma, Rayapa Reddy; Nagarajan, Swathanthra; Mathi, Atchyuta

2013-07-01

146

Hashimoto's thyroiditis associated Evans syndrome: A rare case report on the clustered autoimmune disease triad  

PubMed Central

Evans syndrome is a rare combination of autoimmune hemolytic anemia and immune thrombocytopenia. Their association with autoimmune thyroid diseases has been reported by few authors; however, a sequential development of the Evans syndrome in cases of Hashimoto's thyroiditis is extremely rare. The clustering of these autoimmune diseases might share a common pathogenic pathway. We present the fourth such case in world literature, of a 34-year-old female diagnosed with Hashimoto's thyroiditis in 2006, who has been taking synthetic thyroid hormone since then. Her condition is now clinically complicated with the development of the Evans syndrome.

Koti, Kalyan; Thumma, Rayapa Reddy; Nagarajan, Swathanthra; Mathi, Atchyuta

2013-01-01

147

[Indication and contraindication of radioiodine therapy for Graves' disease].  

PubMed

All patients with Graves' disease are potential candidates for radioiodine therapy with I-131 except during pregnancy and breast feeding. In addition, for those who wish to have babies, at least 6 months of contraception should be observed after administration of I-131 in a therapeutic dose. On top of its famous role as the last resort after severe adverse reaction to antithyroid drugs or at relapse after surgery, this method is also very suitable for subjects who prefer a safe and sure way of cure from hyperthyroidism rather than a prolonged and sometimes unpredictable drug regimen, and for those who wish to reduce their goiter size. Moreover, under exceptional circumstances, children can be treated with radioiodine. Patients with thyroid-associated ophthalmopathy should be followed up closely after I-131 therapy to rule out aggravation of their eye disease. PMID:23214062

Misaki, Takashi

2012-11-01

148

Pathogenesis of thyroid eye disease--does autoimmunity against the TSH receptor explain all cases?  

PubMed

Thyroid associated ophthalmopathy, or thyroid eye disease (TED), is a complex inflammatory disorder of the eye that, as its name implies, is usually associated with thyroid disease. Clinical observation supports the existence of three main TED subtypes, namely ocular myopathy, congestive myopathy, and mixed congestive and myopathic ophthalmopathy. Although the precise pathophysiology of TED remains unclear, it is likely to reflect an autoimmune reaction involving sensitised T lymphocytes and autoantibodies directed against a specific orbital or thyroid-and-orbital shared antigen(s). One well-studied candidate in this immune reaction is the thyroid-stimulating hormone receptor (TSHR), which is also expressed in the orbital fibroblast and preadipocyte. Most patients with ophthalmopathy have associated Graves' disease, 10% have Hashimoto's thyroiditis in which the eye changes are often mild and expressed mainly as upper eyelid retraction (UER), and 10% have no apparent associated thyroid disease - so-called "euthyroid Graves' disease". Ophthalmopathy can also occur in some patients with transient thyroiditis, thyroid cancer, and Graves' disease many years after treatment of the hyperthyroidism - situations where TSHR antibodies are not expected to be present, suggesting that the relationship between TSHR antibodies and the eye disorder has not been established for all cases. In our studies of TED we have investigated the nature and significance of antibodies targeting other eye muscle and orbital connective tissue (OCT) antigens, in particular the calcium binding protein calsequestrin (CASQ1) and the orbital fibroblast membrane antigen collagen XIII. Our working hypotheses for the pathogenesis of TED are: i) the initial reaction in the orbit is antibody and T lymphocyte targeting of the TSHR in the OCT compartment, and ii) the associated extra ocular and upper eyelid muscle inflammation reflects either autoimmunity against primary skeletal muscle antigens such as CASQ1 or a secondary, non specific effect of the OCT reactions as proposed by the main proponents of the "TSHR hypothesis". Here, we review the evidence that autoimmunity against the TSHR expressed in the orbit can be implicated in the development of all cases of TED. Although there is a close general correlation between ophthalmopathy and TSHR antibodies there are many exceptions, suggesting that the continued study of the possible role of autoimmunity against calsequestrin and collagen XIII is justified. PMID:20464711

Wall, Jack R; Lahooti, Hooshang

149

[Pathogenesis of thyroid eye disease - does autoimmunity against the TSH receptor explain all cases?].  

PubMed

Thyroid associated ophthalmopathy, or thyroid eye disease (TED), is a complex inflammatory disorder of the eye that, as its name implies, is usually associated with thyroid disease. Clinical observation supports the existence of three main TED subtypes, namely ocular myopathy, congestive myopathy, and mixed congestive and myopathic ophthalmopathy. Although the precise pathophysiology of TED remains unclear, it is likely to reflect an autoimmune reaction involving sensitised T lymphocytes and autoantibodies directed against a specific orbital or thyroid-and-orbital shared antigen(s). One well-studied candidate in this immune reaction is the thyroid-stimulating hormone receptor (TSHR), which is also expressed in the orbital fibroblast and preadipocyte. Most patients with ophthalmopathy have associated Graves' disease, 10% have Hashimoto's thyroiditis in which the eye changes are often mild and expressed mainly as upper eyelid retraction (UER), and 10% have no apparent associated thyroid disease - so-called "euthyroid Graves' disease". Ophthalmopathy can also occur in some patients with transient thyroiditis, thyroid cancer, and Graves' disease many years after treatment of the hyperthyroidism - situations where TSHR antibodies are not expected to be present, suggesting that the relationship between TSHR antibodies and the eye disorder has not been established for all cases. In our studies of TED we have investigated the nature and significance of antibodies targeting other eye muscle and orbital connective tissue (OCT) antigens, in particular the calcium binding protein calsequestrin (CASQ1) and the orbital fibroblast membrane antigen collagen XIII. Our working hypotheses for the pathogenesis of TED are: i) the initial reaction in the orbit is antibody and T lymphocyte targeting of the TSHR in the OCT compartment, and ii) the associated extra ocular and upper eyelid muscle inflammation reflects either autoimmunity against primary skeletal muscle antigens such as CASQ1 or a secondary, non specific effect of the OCT reactions as proposed by the main proponents of the "TSHR hypothesis". Here, we review the evidence that autoimmunity against the TSHR expressed in the orbit can be implicated in the development of all cases of TED. Although there is a close general correlation between ophthalmopathy and TSHR antibodies there are many exceptions, suggesting that the continued study of the possible role of autoimmunity against calsequestrin and collagen XIII is justified. PMID:22125104

Wall, Jack R; Lahooti, Hooshang

2011-01-01

150

Psychotherapy, Science, and Spirit: Nonlinear Systems, Hakomi Therapy, and the Tao  

Microsoft Academic Search

This article explores how contemporary science may inform psychotherapies that also allow for concepts of “Spirit.” Hakomi therapy is used as one example for exploring such an integration. The discussion begins with tenants from the philosophy of science outlined by Bateson and Wilber, and how Hakomi therapy incorporates them into therapeutic principles also influenced by Buddhism and Taoism. These metaprinciples

Gregory J. Johanson

2009-01-01

151

TAO: a High-performance ORB Endsystem Architecture for Real-time CORBA  

Microsoft Academic Search

Many application domains (such as avionics, telecommuni- cations, and multimedia) require real-time guarantees from the underlying networks, operating systems, and middle- ware components to achieve their quality of service (QoS) requirements. In addition to providing end-to-end QoS guar- antees, applications in these domains must be flexible and reusable. Requirements for flexibility and reusability moti- vate the use of object-oriented middleware

Douglas C. Schmidt; Aniruddha Gokhale; Timothy H. Harrison; David Levine; Chris Cleeland

152

Achieving End-to-end Predictability in the TAO Real-time CORBA ORB  

Microsoft Academic Search

End-to-end predictability of operations is essential for many fixed-priority distributed real-time and embedded (DRE) ap- plications, such as command and control systems, manufactur- ing process control systems, large-scale distributed interactive simulations, and testbeam data acquisition systems. To facil- itate this common requirement, the Real-Time CORBA spec- ification defines standard middleware features that allow ap- plications to allocate, schedule, and control

Irfan Pyarali; Douglas C. Schmidt; Ron K. Cytron

2002-01-01

153

THE TEXT ANALYSIS OBJECT (TAO): ENGAGING STUDENTS IN ACTIVE LEARNING ON THE WEB  

Microsoft Academic Search

At The University of Melbourne, there has been an ongoing effort to place the learning of anatomy within a clinical context by linking anatomical knowledge with clinical practice and diagnosis. This effort has been made in order to overcome the traditional division between structure and application, which characterises much of biological science teaching. In recent times the Faculty of Medicine

David M. Kennedy; Albert Ip; Norm Eizenberg

154

Monitoring, Security, and Dynamic Configuration with the dynamicTAO Reflective ORB  

Microsoft Academic Search

Conventional middleware systems fail to address important issues related to dynamism. Modern computer systems have to deal not only with heterogeneity in the underlying hardware and software platforms but also with highly dynamic environments. Mobile and distributed applications are greatly affected by dynamic changes of the environment characteristics such as security constraints and resource availability. Existing middleware is not prepared

Fabio Kon; Manuel Román; Ping Liu; Jina Mao; Tomonori Yamane; Luiz Claudio Magalhães; Roy H. Campbell

2000-01-01

155

Ethical English Teaching: Learning Democratic Values or Living by the Tao?  

Microsoft Academic Search

This article begins by drawing attention to the similarities between the aims of critical literacy within English and Education for Democratic Citizenship (EDC). It then considers subscribing to liberal values in the English classrooms of a plural society and concludes that, as political liberalism is unlikely to be universally endorsed, we need to look elsewhere for a ‘centre’ that will

Mark Pike

2011-01-01

156

TEM of lattice bending in crystallized areas of anodized Ta-O films  

NASA Astrophysics Data System (ADS)

In the present paper we study the crystals grown in thin, initially amorphous films of tantalum oxide, interesting as possible materials for dielectric (high-k) layers to be applied in microelectronics. Here we employ some straightforward procedures making use of extinction bend contours (that are often observed in crystallizing amorphous films) and obtain indications of strong internal lattice bending in the crystallized areas.

Kolosov, V. Yu; Schwamm, C. L.; Steeds, J. W.

2008-03-01

157

AIP Conference Proceedings #383 from the Taos Meeting: Workshop on the Earth's Trapped Particle Environment  

NASA Astrophysics Data System (ADS)

Studies of the Earth's radiation belts were among the first in situ space experiments in the late 1950s, the 1960s, and the early 1970s. A series of annual McCormack-conferences were held during those early years. After that the field received less attention and decreasing resources; during the late 1970s and the 1980s radiation belt physics were discussed at only a few topical conferences. However, the fields of radiation belt and ring current research experienced a small renaissance during the 1990s.

Spjeldvik, Walther N.

158

Relapse Prevention for Alcohol and Drug Problems: That Was Zen, This Is Tao  

Microsoft Academic Search

Relapse prevention, based on the cognitive-behavioral model of relapse, has become an adjunct to the treatment of numerous psychological problems, including (but not limited to) substance abuse, depression, sexual offending, and schizophrenia. This article provides an overview of the efficacy and effectiveness of relapse prevention in the treatment of addictive disorders, an update on recent empirical support for the elements

Katie Witkiewitz; G. Alan Marlatt

2004-01-01

159

The design of the TAO real-time object request broker  

Microsoft Academic Search

Many real-time application domains can benefit from flexible and open distributed architectures, such as those defined by the CORBA specification. CORBA is an architecture for distributed object computing being standardized by the OMG. Although CORBA is well-suited for conventional request\\/response applications, CORBA implementations are not yet suited for real-time applications due to the lack of key quality of service (QoS)

Douglas C. Schmidt; David L. Levine; Sumedh Mungee

1998-01-01

160

Recovering the language of Tao: Cultural transformation of Chinese pedagogic discourse  

Microsoft Academic Search

With the progress of modernization of the Chinese society starting from early 20 th century, the Chinese language in terms of discourse has experienced a fundamental change which meanwhile has transformed the mode of Chinese pedagogic practices. Modern Chinese discourses, no matter whether of social or scientific practices or even on China's intellectual heritage, are articulated to a large extent

Wu Zongjie

161

Draw point mapping at the Questa Molybdenum Mine, Taos County, New Mexico  

SciTech Connect

Mining of molybdenum at Questa, New Mexico has been accomplished by block cave methods since August, 1983. As caving progresses, a periodic geologic evaluation is made of the rock-types present in finger raises on the Grizzly Level of the mine. The production maturity of the cave can be monitored by relating this data to geologic cross-sections through the ore body. The draw point mapping program is a simple and effective tool that is used in making draw control decisions at Questa.

Schulz, M.G.

1985-01-01

162

The varying universe: Participation of NCU in TAOS and Pan-STARRS1 projects  

Microsoft Academic Search

Time-domain astronomy is an important branch in modern astrophysics, as many celestial objects exhibit variability in time. In the up-coming decade there will be a number of time- domain surveys that will produce huge volume of data available to the astronomical community. In this paper we summarize the participation of National Central University (NCU) in the research of time-domain astronomy.

Chow-Choong Ngeow; Wen-Ping Chen; Daisuke Kinoshita; Yi Chou; Wing-Huen Ip

2011-01-01

163

Geologic map of the Ojo Caliente Quadrangle, Rio Arriba and Taos Counties, New Mexico  

SciTech Connect

The Ojo Caliente area forms part of the western limb of the Espanola basin within the Rio Grande rift of northern New Mexico (Manley, 1979; May, 1979). The geology consists of Miocene basin-fill sedimentary rocks that rest unconformably on, or are faulted against, Proterozoic crystalline metamorphic rocks. The Miocene rocks dip gently to the southeast, except where the attitudes are controlled by faulting or by the underlying basement topography. The Precambrian and Miocene rocks are unconformably overlain by Quaternary pediment and river gravels, loess, travertine, landslide debris, and alluvium. The Precambrian rocks are faulted into horsts in several areas by north - northeast - trending normal faults.

Stix, J. (comp.)

1986-11-01

164

Verrucosispora andamanensis sp. nov., isolated from the marine sponge collected in Andaman sea (Tao island), Thailand.  

PubMed

An actinomycete strain, SP03-05T, was isolated from marine sponge sample (Xestospongia sp.) collected from Phuket Province of Thailand. The strain is aerobic, Gram-positive and produced single spores at the tip of the substrate mycelium. Strain SP03-05T was contained meso-diaminopimelic acid in the peptidoglycan, whole cell sugars were arabinose, galactose, glucose, rhamnose, ribose and xylose. The polar lipids profile of strain SP03-05T consisted of phosphatidylethanolamine, diphosphatidylglycerol, phosphatidylinositol, phosphatidylinositol mannosides and unknown polar lipids. Morphological and chemotaxonomic characteristics of the strain were identified as a member of the family Micromonosporaceae. Phylogenetic analysis based on 16S rRNA gene sequence analysis of the strain showed similarity to Verrucosispora lutea YIM 013T (96.90%), Verrucosispora sediminis MS426T (96.90%), Verrucosispora gifhornensis DSM 44337T (96.80%), Verrucosispora maris AB-18-032T (96.80%) and Verrucosispora qiuiae RtIII47T (95.40%). The DNA G+C content was 72.4 mol%. The phenotypic, genotypic and DNA-DNA hybridization results supported that the classification of this strain as a novel species in the genus Verrucosispora, for which the name Verrucosispora andamanensis sp. nov. is proposed. The type strain is SP03-05T (=BCC 45620T =NBRC 109075T). PMID:23710052

Supong, Khomsan; Suriyachadkun, Chanwit; Suwanborirux, Khanit; Pittayakhajonwut, Pattama; Thawai, Chitti

2013-05-24

165

TOGA-TAO AND THE 1991--93 EL NINO-SOUTHERN OSCILLATION EVENT  

Microsoft Academic Search

THE EL N~r~o-SOUTHERN OSCILLATION (ENSO) phenomenon is an interannual perturbation of the climate system characterized by aperiodic weaken- ing of the tradewinds and warming of the surface layers in the equatorial Pacific Ocean every 4-7 years. The impacts of ENSO are felt worldwide through disruption of the atmospheric general cir- culation and associated global weather patterns (Rasmusson and Wallace, 1983;

Michael J. McPhaden

166

A new MRI method for the quantitative evaluation of extraocular muscle size in thyroid ophthalmopathy  

Microsoft Academic Search

In cross section, extraocular muscles are more or less elliptical, with short and long diameters. We studied the ratio (R) of short to long diameter and investigated its use in quantitative assessment of the extraocular muscles in patients with Graves's disease. We measured the diameters on T1-weighted axial and coronal MRI and computed R for each extraocular muscle in 80

K. Aydin; K. Güven; S. Sencer; A. C?k?m; N. Gül; O. Minareci

2003-01-01

167

CONSENSUS STATEMENT: Subclinical Thyroid Dysfunction: A Joint Statement on Management from the American Association of Clinical Endocrinologists, the American Thyroid Association, and The Endocrine Society  

Microsoft Academic Search

UBCLINICAL THYROID DYSFUNCTION is a common clinical problem for which there are many controversial issues regarding screening, evaluation, and management. Subclin- ical hypothyroidism is defined as an elevated serum thyroid- stimulating hormone (TSH) level associated with normal to- tal or free thyroxine (FT4) and free triiodothyronine (FT3) levels. The overall prevalence is 4% to 10% in the general population, and

Hossein Gharib; R. Michael Tuttle; H. Jack Baskin; Lisa H. Fish; Peter A. Singer; Michael T. McDermott

168

BRAF mutation is unusual in chronic lymphocytic thyroiditis-associated papillary thyroid carcinomas and absent in non-neoplastic nuclear atypia of thyroiditis  

Microsoft Academic Search

Chronic lymphocytic thyroiditis (CLT) has an epidemiological relationship to papillary thyroid carcinoma (PTC). The follicular\\u000a epithelium in CLT can be markedly atypical, with cytologic changes ranging from oncocytic morphology to clearing and overlapping.\\u000a At the molecular level, the association between CLT and PTC is more controversial. In order to further characterize the molecular\\u000a changes in CLT, this study examined the

Rachel Sargent; Virginia LiVolsi; Justin Murphy; Geeta Mantha; Jennifer L. Hunt

2006-01-01

169

[Impact of the application of the american thyroid association criteria on the diagnosis of hypothyroidism in pregnant women in Vigo, Spain].  

PubMed

In order to determine the impact of the application of the American Thyrold Associations (ATA) criteria for the diagnosis of hypothyroidism in pregnant women in the health district of Vigo, Spain, concentrations of serum thyrotropin (TSH), free thyroxine (T4L) and anti-thyroid antibodies were analyzed, comparing the frequency of pregnant women diagnosed with hypothyroidism and applying the criteria used in the hormone laboratory at Xeral Hospital and referential criteria established by ATA. The application of ATA referential criteria increased by 29.6% the number of female patients diagnosed with hypothyroidism. The application of ATA guidelines had an impact on the measurement of TSH concentrations in pregnant women, which calls for an evaluation of referential values of TSH based on the population and the local diagnostic methods. PMID:24100817

Pombar-Pérez, Marta; Penín-Álvarez, Manuel; Vélez-Castillo, María; Trigo-Barros, Cristina; Alvarez-García, Elías; Rodríguez-Ferro, Rosa

2013-09-01

170

Intercomparison of Bulk Aerodynamic Algorithms for the Computation of Sea Surface Fluxes Using TOGA COARE and TAO Data  

Microsoft Academic Search

A bulk aerodynamic algorithm is developed for all stability conditions for the computation of ocean surface fluxes. It provides roughness lengths of wind, humidity, and temperature for a wind speed range from 0 to 18 m s1: zo = 0.013u2\\/g + 0.11\\/u and ln(zo\\/zot) = ln(zo\\/zoq) = 2.67Re1\\/4 2.57 as derived using the Tropical Oceans Global Atmosphere (TOGA) Coupled Ocean-Atmosphere

Xubin Zeng; Ming Zhao; Robert E. Dickinson

1998-01-01

171

Synthesis of lead-free (K, Na)(Nb, Ta)O3 nanopowders using a sol-gel process.  

PubMed

Lead-free (K0.5Na0.5)(Nb0.7Ta0.3)O3 piezoelectric material was successfully synthesized via a sol-gel process. Crystalline (K0.5Na0.5)(Nb0.7Ta0.3)O3 nanopowders were obtained after heat treatment at 700 degrees C. The particle size was estimated to be 87nm +/- 23 nm. The transmission electron microscopy images showed that individual nanoparticles were single crystalline and had a pseudo-cubic structure with a lattice parameter of -3.96 angstroms. Both X-ray diffraction and scanning electron microscopy studies consistently showed that the crystallization of the (K0.5Na0.5)(Nb0.7Ta0.3)O3 occurred slightly above 500 degrees C. The samples have an appropriate stoichiometry as found via energy dispersive X-ray spectroscopy. The demonstration of the synthesis of (K0.5Na0.5)(Nb0.7Ta0.3)O3 via a sol-gel process as presented in this paper can provide an important foundation for the development of a synthetic route towards (K0.5Na0.5)(Nb0.7Ta0.3)O3 doped with various other elements for high performance piezoelectric devices. PMID:22849167

Rajesh, Dodla; Kim, Seungwook; Jeong, Jinhoo; Nahm, Sahn; Kim, Woong

2012-04-01

172

Insights from SMPY's Greatest Former Child Prodigies: Drs. Terence ("Terry") Tao and Lenhard ("Lenny") Ng Reflect on Their Talent Development  

ERIC Educational Resources Information Center

|If the academic needs of the most profoundly gifted students can be met through the use of existing educational practices, specialists in gifted education can assume that the educational needs of less able, but still academically talented, students can also be met by using some combination of these strategies as well. This paper illustrates the…

Muratori, Michelle C.; Stanley, Julian C.; Ng, Lenhard; Ng, Jack; Gross, Miraca U. M.; Tao, Terence; Tao, Billy

2006-01-01

173

Evaluation of a hybrid satellite- and NWP-based turbulent heat flux product using Tropical Atmosphere-Ocean (TAO) buoys  

Microsoft Academic Search

Gridded hybrid turbulent heat flux fields were created by applying the state-of-the-art Coupled Ocean-Atmosphere Response Experiment (COARE) version 3.0 bulk algorithm to state variables (sea surface temperature, winds relative to currents, air temperature, and air specific humidity) derived from either numerical weather prediction (NWP) reanalysis (National Centers for Environmental Prediction–National Center for Atmospheric Research (NCEP-NCAR) reanalysis (NCEP1), NCEP reanalysis-2 (NCEP2),

ChuanLi Jiang; Meghan F. Cronin; Kathryn A. Kelly; LuAnne Thompson

2005-01-01

174

Evaluation of a hybrid satellite- and NWP-based turbulent heat flux product using Tropical Atmosphere-Ocean (TAO) buoys  

Microsoft Academic Search

Gridded hybrid turbulent heat flux fields were created by applying the state-of-the-art Coupled Ocean-Atmosphere Response Experiment (COARE) version 3.0 bulk algorithm to state variables (sea surface temperature, winds relative to currents, air temperature, and air specific humidity) derived from either numerical weather prediction (NWP) reanalysis (National Centers for Environmental Prediction-National Center for Atmospheric Research (NCEP-NCAR) reanalysis (NCEP1), NCEP reanalysis-2 (NCEP2),

ChuanLi Jiang; Meghan F. Cronin; Kathryn A. Kelly; LuAnne Thompson

2005-01-01

175

Ba(Mg, Ta)O3-BaSnO3 High-Q Dielectric Resonator  

Microsoft Academic Search

Dense ceramics with the chemical formula (1-X)Ba(Mg1\\/3Ta2\\/3)O3-XBaSnO3(X{=}0--0.15) are prepared for use as dielectric resonators. The obtained dielectric constant and Q value for Ba(Mg1\\/3Ta2\\/3)O3 were 24 and 43000 at 10 GHz, respectively. As X increased from 0 to 0.15, the temperature coefficient of resonant frequency decreased gradually from 5.4 to -0.5 ppm\\/°C. At X{=}0.05, the Q value decreased drastically, and at

Hiroyuki Matsumoto; Hiroshi Tamura; Kikuo Wakino

1991-01-01

176

Background Characterisation Study of Naturally Occurring Acid Rock Drainage in the Sangre De Cristo Mountains, Taos County, New Mexico  

Microsoft Academic Search

A background characterisation study was carried out in the Sangre de Cristo mountains, New Mexico, to: 1. quantify naturally occurring contaminant loads from mineralised areas; 2. define site-specific background concentrations; and 3. to determine key factors controlling spatial and temporal variations in contaminant concentrations. The study included a comprehensive sampling and testing program (paste pH\\/EC, ABA, leach extraction tests) of

S Shaw; C Wels; A Robertson; S Fortin; B Walker

2003-01-01

177

Trial study on DENG Tie-tao’s Coronary Heart Disease Capsules in improving patients’ quality of life  

Microsoft Academic Search

Objective: To assess the efficacy of the Coronary Heart Disease (CHD) Capsules worked out by Prof. Deng — in improving quality of life\\u000a of CHD patients of qi deficiency with phlegm and blood stasis syndrome.Method: According to the WHOs diagnosis criteria of CHD, a total of 93 stable angina patients were divided into 3 groups using the\\u000a single blinded method.

Wu Huan-lin; Wang Xia; Li Xin-mei; Luo Wen-jie; Deng Tie-tao

2005-01-01

178

Insights From SMPy's Greatest Former Child Prodigies: Drs. Terence (“Terry”) Tao and Lenhard (“Lenny”) Ng Reflect on Their Talent Development  

Microsoft Academic Search

If the academic needs of the most profoundly gifted students can be met through the use of existing educational practices, specialists in gifted education can assume that the educational needs of less able, but still academically talented, students can also be met by using some combination of these strategies as well. This paper illustrates the feasibility and effectiveness of utilizing

Michelle C. Muratori; Julian C. Stanley; Lenhard Ng; Jack Ng; Miraca U. M. Gross; Terence Tao; Billy Tao

2006-01-01

179

ANIR: Infrared-Optical Simultaneous Imager for miniTAO 1 m Telescope at an Altitude of 5640 m  

SciTech Connect

Early follow-up observations of gamma-ray bursts (GRBs) in wide wavelength range, especially from the optical to the near infrared (NIR) bands, are crucial for search of high-redshift GRBs by detecting their Lyman limit break. For this purpose, we have developed a NIR/optical simultaneous imager called ANIR (Atacama Near InfraRed camera) for the University of Tokyo Atacama 1.0 m telescope. Installed at the summit of Co. Chajnantor (5640 m altitude) in northern Chile, this telescope is the world's highest optical/NIR observatory. ANIR saw the first light in June 2009, and several observing runs have been carried out for performance verification as well as scientific observations. During the run, we have successfully detected an optical/NIR afterglow of GRB091018. Thanks to the excellent seeing (median {approx}0''.8), 5{sigma} limiting magnitudes reach 23.3, 20.6, and 20.8 mag(AB) in the B, J and Ks bands, respectively, with 600 sec exposure.

Motohara, Kentaro; Konishi, Masahiro; Mitani, Natsuko; Sako, Shigeyuki; Uchimoto, Yuka K.; Toshikawa, Koji; Minezaki, Takeo; Tanabe, Toshihiko; Miyata, Takashi; Koshida, Shintaro; Nakamura, Tomohiko; Asano, Kentaro; Yoshii, Yuzuru; Doi, Mamoru; Kohno, Kotaro; Tanaka, Masuo; Kawara, Kimiaki; Handa, Toshihiro [Institute of Astronomy, University of Tokyo, Osawa 2-21-1, Mitaka, Tokyo 181-0015 (Japan); Ohsawa, Ryou; Umeda, Hideyuki [Department of Astronomy, University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033 (Japan)

2010-10-15

180

Movement as a Metaphor: How Persistence, the Tao, and the Wisdom of the Ostrich Helped Build School Dance Programs  

ERIC Educational Resources Information Center

|Those who advocate for dance in education inevitably face many roadblocks, including ignorance of how dance can contribute to education, implementation of standardized performance assessments, lack of funding, entrenched issues of politics and power, and fear and discomfort about the body. It is dance teachers' responsibility to enlighten,…

Kaufman, Karen

2011-01-01

181

The plastic surgeon and Graves disease.  

PubMed

Thyroid-associated ophthalmopathy is a disease caused by autoimmune processes that also affects the thyroid gland and the lower limbs; at orbital level, it involves the muscle and adipose tissue. When medical treatment fails to achieve appreciable results, surgery aims to decompress the orbital cavity. In recent years, the treatment has been considerably improved by the introduction of transpalpebral lipectomy, which has produced valid results especially in cases when extrinsic muscle hypertrophy is limited; if it is severe, however, lipectomy can be combined with expansion of the orbital cavity, thus enabling the latter to be restricted to one or two walls instead of three. Studying 52 patients who underwent orbital decompression involving lipectomy and/or orbital expansion, affecting a total of 96 orbits, enabled an assessment of the pros and cons of the single techniques in an attempt to identify a rational approach to this pathology. It emerged that lipectomy alone may suffice and obtain valid results in cases of mild-to-moderate proptosis (up to 24 mm) with limited extrinsic muscle hypertrophy, whereas orbital expansion--with or without lipectomy--is likely to be necessary in moderate-to-severe cases (proptosis greater than 24 mm). Additional procedures to correct the elevator and retractor muscles of the eyelids were almost always necessary. PMID:15605519

Chiarelli, A

182

Association of MICA Alleles with Autoimmune Thyroid Disease in Korean Children  

PubMed Central

Background. Major histocompatibility complex class I chain-related gene A (MICA) is a ligand for the activating NKG2D receptor expressed on natural killer (NK) cells. We aimed to assess the association of MICA polymorphism with autoimmune thyroid disease (AITD) in Korean children. Methods. Eighty-one patients with AITD were recruited. We analyzed MICA polymorphisms by PCR-SSP and compared the results with those of 70 healthy controls. Results. In AITD, the allele frequencies of MICA?010 (OR = 2.21; 95% CI, 1.30–3.76, P < 0.003, Pc < 0.042) were higher than those of controls. Patients who did not have thyroid-associated ophthalmopathy showed higher frequencies of MICA?010 (OR = 2.99; 95% CI, 1.47–6.08, P < 0.003, Pc < 0.042) and lower frequencies of MICA?008 (OR = 0.08; 95% CI, 0.01–0.62, P < 0.001, Pc < 0.014) compared to those of controls. HLA-B?46, which shows the strongest association with AITD compared with other HLA alleles, showed the strongest linkage disequilibrium with MICA?010. Analyses of the associations between MICA?010 and HLA-B?46 with AITD suggest an association of the MICA allele with AITD. Conclusions. Our results suggest that innate immunity might contribute to the pathogenesis of AITD.

Cho, Won Kyoung; Jung, Min Ho; Park, So Hyun; Baek, In Cheol; Choi, Hee-Baeg; Kim, Tai-Gyu; Suh, Byung-Kyu

2012-01-01

183

Questa baseline and premining ground-water quality investigation. 8. Lake-sediment geochemical record from 1960 to 2002, Eagle Rock and Fawn Lakes, Taos County, New Mexico  

USGS Publications Warehouse

Geochemical studies of lake sediment from Eagle Rock Lake and upper Fawn Lake were conducted to evaluate the effect of mining at the Molycorp Questa porphyry molybdenum deposit located immediately north of the Red River. Two cores were taken, one from each lake near the outlet where the sediment was thinnest, and they were sampled at 1-cm intervals to provide geochemical data at less than 1-year resolution. Samples from the core intervals were digested and analyzed for 34 elements using ICP-AES (inductively coupled plasma-atomic emission spectrometry). The activity of 137Cs has been used to establish the beginning of sedimentation in the two lakes. Correlation of the geochemistry of heavy-mineral suites in the cores from both Fawn and Eagle Rock Lakes has been used to develop a sedimentation model to date the intervals sampled. The core from upper Fawn Lake, located upstream of the deposit, provided an annual sedimentary record of the geochemical baseline for material being transported in the Red River, whereas the core from Eagle Rock Lake, located downstream of the deposit, provided an annual record of the effect of mining at the Questa mine on the sediment in the Red River. Abrupt changes in the concentrations of many lithophile and deposit-related metals occur in the middle of the Eagle Rock Lake core, which we correlate with the major flood-of-record recorded at the Questa gage at Eagle Rock Lake in 1979. Sediment from the Red River collected at low flow in 2002 is a poor match for the geochemical data from the sediment core in Eagle Rock Lake. The change in sediment geochemistry in Eagle Rock Lake in the post-1979 interval is dramatic and requires that a new source of sediment be identified that has substantially different geochemistry from that in the pre-1979 core interval. Loss of mill tailings from pipeline breaks are most likely responsible for some of the spikes in trace-element concentrations in the Eagle Rock Lake core. Enrichment of Al2O3, Cu, and Zn occurred as a result of chemical precipitation of these metals from ground water upstream in the Red River. Comparisons of the geochemistry of the post-1979 sediment core with both mine wastes and with premining sediment from the vicinity of the Questa mine indicate that both are possible sources for this new component of sediment. Existing data have not resolved this enigma.

Church, S. E.; Fey, D. L.; Marot, M. E.

2005-01-01

184

A Comparative Analysis of Life Situations of Rural Youth from Two Different Cultural Settings: Northern Taos County, New Mexico, and Eastern Holmes County, Ohio.  

ERIC Educational Resources Information Center

|A comparative, interpretive analysis of the social organization of contrasting groups of rural youth from New Mexico ad Ohio was approached from an ethnomethodological perspective, relying on direct observation, intensive personal interviews, and key informants to produce a broader understanding of particular youth coping with their social…

Kuvlesky, William P.

185

The life of tropical Hot Event in November 2006 (HE0611) observed by advanced satellite sensors and the TAO/TRITON mooring array (Invited)  

NASA Astrophysics Data System (ADS)

We have found Hot Event (HE), which is a short-term (about 20 days) large-scale (about 15x106km2) phenomenon with very high Sea Surface Temperature (SST>30 degC). A HE was identified in the tropical western Pacific in November 2006, which is named HE0611. Two parts (HE0611-East and -West) with very high SST connected to form HE0611. SST in HE0611-West increases quickly with large diurnal SST variations, which is caused by large solar radiation and suppressed latent heat flux. Formation mechanism of HE0611-East is completely different; its very high SST is supported sub-surface high SST anomaly associated with the El Nino. Cloud motion wind and cloud cover data have shown deep convective systems with divergent air flows in HE0611-East. High-level convergence was derived from cloud motion winds over HE0611-West. Cloud-free conditions with convergent flow were considered to be related to the deep convection over HE0611-East. These interactions through the whole troposphere over HE0611 (Figure 1) may have been a true appearance of “remote convection” which has been suggested as a mechanism of very high SST generation in tropical oceans. Using satellite-observed surface winds and atmospheric sounding data, the collapse process of HE0611 is investigated. Sudden strengthening of the subtropical-high-enhanced surface easterly winds moved a deep convective system from HE0611-East to -West. A cloud fraction separated from the moved deep convection may have lifted air parcels for initiation of a new convection system in HE0611-West. A pronounced increase of surface level convective available potential energy (CAPE) and the decrease of convective inhibition indicated enhanced convective instability over HE0611-West. Increases of the mass mixing rate and equivalent potential temperature in the boundary layer were caused by water vapor supply associated with the very high SST in HE0611-West, which enhanced CAPE for the deep convection development. With the development of deep convection over HE0611-West, HE0611 ended when the very high SST was destroyed by increased heat fluxes and enhanced mechanical mixing in the surface layer. Figure 1 Schematic diagram of the interaction between HE0611-West and -East when the deep convective system developed over HE0611-East. Solar radiation and latent heat flux for HE0611-West and -East are listed at the bottom.

Kawamura, H.; Qin, H.

2010-12-01

186

Structure Determination of A2M3+TaO6 and A2M3+NbO6 Ordered Perovskites: Octahedral Tilting and Pseudosymmetry  

SciTech Connect

The room-temperature crystal structures of six A{sub 2}M{sup 3+}M{sup 5+}O{sub 6} ordered perovskites have been determined from neutron and X-ray powder diffraction data. Ba{sub 2}YNbO{sub 6} adopts the aristotype high-symmetry cubic structure (space group Fm{bar 3}m, Z = 4). The symmetries of the remaining five compounds were lowered by octahedral tilting distortions. Out-of-phase rotations of the octahedra about the c axis were observed in Sr{sub 2}CrTaO{sub 6} and Sr{sub 2}GaTaO{sub 6} which lowers the symmetry to tetragonal (space group = I4/m, Z = 2, Glazer tilt system = a{sup 0}a{sup 0}c{sup -}). Octahedral tilting analogous to that seen in GdFeO{sub 3} occurs in Sr{sub 2}ScNbO{sub 6}, Ca{sub 2}AlNbO{sub 6} and Ca{sub 2}CrTaO{sub 6}, which lowers the symmetry to monoclinic (space group P2{sub 1}/n, Z = 2, Glazer tilt system = a{sup -}a{sup -}c{sup +}). The Sr{sub 2}MTaO{sub 6} (M = Cr, Ga, Sc) compounds have unit-cell dimensions that are highly pseudo-cubic. Ca{sub 2}AlNbO{sub 6} and Ca{sub 2}CrTaO{sub 6} have unit-cell dimensions that are strongly pseudo-orthorhombic. This high degree of pseudosymmetry complicates the space-group assignment and structure determination. The space-group symmetries, unit-cell dimensions and cation ordering characteristics of an additional 13 compositions, as determined from X-ray powder diffraction data, are also reported. An analysis of the crystal structures of 32 A{sub 2}MTaO{sub 6} and A{sub 2}MNbO{sub 6} perovskites shows that in general the octahedral tilt system strongly correlates with the tolerance factor.

Barnes,P.; Lufaso, M.; Woodward, P.

2006-01-01

187

A new perovskite phase Li 2 x Ca 0.5? x TaO 3: Li + ion conductivity and use as pH sensor  

Microsoft Academic Search

Several compounds of a new solid solution Li2xCa0.5?xTaO3 (0.05?x?0.25) with perovskite structure have been synthesised by classical solid state reaction. It has been found that synthesis at 1773 K followed by a quenching in air was necessary to obtain a pure perovskite phase. The cell parameters and their variation with composition x have been determined through X-ray diffraction patterns analysis.

Quoc Nghi Pham; Claude Bohnke; Joël Emery; Odile Bohnke; Françoise Le Berre; Marie-Pierre Crosnier-Lopez; Jean-Louis Fourquet; Pierre Florian

2005-01-01

188

A case study of the tropical Hot Event in November 2006 (HE0611) using a geostationary meteorological satellite and the TAO\\/TRITON mooring array  

Microsoft Academic Search

Qin et al. have found Hot Events (HE), which are short-term (about 20 days) large-scale (about 15,000,000 km2) regions with very high Sea Surface Temperatures (SST > 30°C). Following their definition, an HE was identified in the tropical western Pacific in November 2006, which is named HE0611. A case study of HE is conducted by using the advanced satellite products

Huiling Qin; Hiroshi Kawamura; Futoki Sakaida; Kentaro Ando

2008-01-01

189

Thyroid nodule guidelines: agreement, disagreement and need for future research  

Microsoft Academic Search

This article reviews agreement, disagreement and need for future research of the thyroid nodule guidelines published by the British Thyroid Association, National Cancer Institute, American Thyroid Association and the joint, transatlantic effort of three large societies, the American Society of Clinical Endocrinologists, Associazione Medici Endocrinologi and the European Thyroid Association, published in 2010. Consensus exists for most topics in the

Laszlo Hegedüs; Erik Alexander; Roberto Valcavi; Enrico Papini; Hossein Gharib; Ralf Paschke

2011-01-01

190

Alternative schemes for production of chilled water and cogeneration of electricity at Ashley Plant.  

National Technical Information Service (NTIS)

William Tao & Associates, Inc. (TAO) evaluated alternative systems for the generation of Chilled Water at Ashley Plant. The generation of chilled water is necessary for several reason; initially as a source of revenue for St. Louis Thermal Energy Corporat...

1989-01-01

191

77 FR 37941 - Order Granting a Limited Exemption From Exchange Act Rule 10b-17 to Certain Actively Managed...  

Federal Register 2010, 2011, 2012, 2013

...See, e.g., Letter from Josephine J. Tao, Assistant Director to W. John McGuire...16, 2011); Letter from Josephine J. Tao, Assistant Director to Jeremy Senderowicz...1, 2012) and Letter from Josephine J. Tao, Assistant Director to Jack P....

2012-06-25

192

A New Generation of Tactical Action Officer Intelligent Tutoring System (ITS)  

Microsoft Academic Search

Stottler Henke is developing for the US Navy's Surface Warfare Officer's School (SWOS) a new generation of Tactical Action Officer (TAO) Intelligent Tutoring System (ITS), interfaced to the Generic Reconfigurable Training System (GRTS). The GRTS TAO ITS allows TAO students to interact naturally using spoken language to command and query simulated entities corresponding to other crew members and off-ship personnel.

Richard Stottler; Susan Panichas

2006-01-01

193

Direct medical cost of pelvic inflammatory disease and its sequelae: decreasing, but still substantial 1 1 The authors thank Anne Haddix, PhD, and Guoyu Tao, PhD, for their methodologic advice  

Microsoft Academic Search

Objective: To estimate direct medical costs and average lifetime cost per case of pelvic inflammatory disease (PID).Methods: We estimated the direct medical expenditures for PID and its three major sequelae (chronic pelvic pain, ectopic pregnancy, and infertility) and determined the average lifetime cost of a case of PID and its sequelae. We analyzed 3 years of claims data of privately

David B Rein; William J Kassler; Kathleen L Irwin; Lara Rabiee

2000-01-01

194

Characterization of a Self-sufficient Trans-Anethole Oxygenase from Pseudomonas putida JYR-1  

PubMed Central

A novel flavoprotein monooxygenase, trans-anethole oxygenase (TAO), from Pseudomonas putida JYR-1, which is capable of catalyzing the oxidation of trans-anethole to p-anisaldehyde, was heterologously expressed in E. coli and purified. Enzymatic kinetics of diverse substrates and cofactors revealed that TAO is likely to be a novel self-sufficient flavoprotein monooxygenase. Enzyme assays of GST-TAO demonstrated that TAO catalyzed a trans-anethole oxidation reaction without auxiliary component enzyme-like electron-transfer flavin reductases. The single component TAO had the ability to reduce flavin cofactors and simultaneously oxidize trans-anthole to p-anisaldehyde. In the processes of reduction of flavin and oxidation of trans-anethole, TAO accepted various flavin and NAD(P)H cofactors. TAO also catalyzed oxidation of isoeugenol, O-methyl isoeugenol, and isosafrole, all of which contain the 2-propenyl functional group on the aromatic ring structure with different catalytic efficiency. TAO had the greatest catalytic efficiency (kcat/Km) with the original substrate, trans-anethole. Investigation about partially deleted mutants of TAO indicated that reductase active sites appeared to be located near the N terminal. Site directed mutagenesis studies also proved that the proposed flavin binding sites, Trp-38, Thr-43, Tyr-55, were critical for flavin reduction. However, disruption of any portion of TAO eliminated the oxygenase activity.

Han, Dongfei; Sadowsky, Michael J.; Chong, Youhoon; Hur, Hor-Gil

2013-01-01

195

Current Status of Patients with Buerger Disease in Japan  

PubMed Central

The prevalence and clinical characteristics of Japanese patients with Buerger disease (thromboangiitis obliterans: TAO) were analyzed based on the Ministry of Health, Labour and Welfare (MHLW) database in 2009. A total of 129 new patients and 3639 patients in follow-up were selected according to the clinical criteria of TAO. The current number of patients with TAO in Japan is estimated at about 4000. The clinical course is relatively favorable, and the rates of limb morbidity and mortality were not completely discouraging.

2013-01-01

196

The Use of Gyroscope Feedback in the Control of the Walking Gaits for a Small Humanoid Robot  

Microsoft Academic Search

\\u000a This paper describes methods used in stabilizing the walking gait of Tao-Pie-Pie, a small humanoid robot given rate feedback from two RC gyroscopes. Tao-Pie-Pie is a fully autonomous small humanoid robot (30cm tall). Although Tao-Pie-Pie uses a minimal set of actuators and sensors, it has proven itself in international competitions, winning honors at the RoboCup\\u000a and HuroSot competitions in 2002

Jacky Baltes; Sara Mcgrath; John Anderson

2004-01-01

197

Identity of Exophthalmic Activity of the Hypophysis and the Blood Serum.  

National Technical Information Service (NTIS)

Biological tests were conducted on carps. A study was made of the developmental periods of the maximal exophthalmic reaction in response to the administration of thyrotropin and blood sera of patients suffering from ophthalmopathy. It was found that blood...

Z. A. Avenirova V. V. Potin G. S. Stepanov

1970-01-01

198

Management of the Nontoxic Multinodular Goiter in Latin America: Comparison with North America and Europe, an Electronic Survey  

Microsoft Academic Search

To assess diagnostic and therapeutic approaches to nontoxic multinodular goiter and to compare them with previously reported American Thyroid Association (ATA) and European Thyroid Association (ETA) surveys, an online questionnaire was distributed to Latin American Thyroid Society (LATS) members. An index case was presented (42-yr-old woman with an enlarged, irregular, nontender, 50- to 80-g thyroid and no clinical suspicion of

Leandro Arthur Diehl; Valdinei Garcia; Steen J. Bonnema; Laszlo Hegedus; Claudio Cordeiro Albino

199

Activation of cytokines corroborate with development of inflammation and autoimmunity in thromboangiitis obliterans patients  

PubMed Central

Thromboangiitis obliterans (TAO) is a segmental inflammatory occlusive disorder that affects the arm and leg arteries of young smokers. The immune system seems to play a critical role in the aetiology of TAO; however, knowledge of the aspects involved in the progression of vascular tissue inflammation and, consequently, the evolution of this disease is still limited. This study was carried out to investigate the cytokine levels of tumour necrosis factor (TNF)-?, interleukin (IL)-1?, IL-4, IL-17 and IL-23 in the plasma of TAO patients presenting with acute clinical manifestations. The study included 20 TAO patients (n = 10 women; n = 10 men) aged 38–59 years under clinical follow-up, classified into two groups: (i) TAO former smokers (n = 11) and (ii) TAO active smokers (n = 9); the control groups included normal volunteer non-smokers (n = 10, active smokers (n = 10) and former smokers (n = 10). Patients' plasma samples were measured using the sandwich enzyme-linked immunosorbent assay. Statistical analyses were performed using the non-parametric Mann–Whitney U-test, with parameters significant at P < 0·05. The activities of all cytokines were different in groups of TAO patients when compared with normal controls, and decreased for control smokers. Increased levels of TNF-?, IL-1?, IL-4, IL-17 and IL-23 were significant in patients with TAO when compared to the controls (P < 0·005, all parameters). The results presented here indicate an increased production of cytokines in TAO, possibly contributing to the inflammatory response observed in the patients' vascular levels. In addition, the increased levels of IL-17 and IL-23 suggest that the disturbance of TAO is involved with mechanisms of autoimmunity. Thus, the discovery of IL-17 and its association with inflammation and autoimmune pathology has reshaped our viewpoint regarding the pathogenesis of TAO, which was based previously on the T helper type 1 (Th1)–Th2 paradigm.

Dellalibera-Joviliano, R; Joviliano, E E; Silva, J S; Evora, P R B

2012-01-01

200

Vascular function and circulating progenitor cells in thromboangitis obliterans (Buerger's disease) and atherosclerosis obliterans.  

PubMed

Thromboangitis obliterans (TAO; Buerger's disease) and atherosclerosis obliterans (ASO) are associated with endothelial dysfunction. The purpose of this study was to evaluate the role of circulating progenitor cells (CPCs) in endothelial function in patients with TAO and ASO. We measured flow-mediated vasodilation (FMD), nitroglycerine-induced vasodilation, and circulating CPCs in 30 patients with TAO and 30 age- and sex-matched healthy subjects and in 40 patients with ASO. FMD was smaller in both the TAO group and ASO group than in the control group (6.6 ± 2.7%, 5.7 ± 3.3% versus 9.5 ± 3.1%, P<0.0001, respectively). There was no significant difference in FMD between the TAO group and ASO group. Nitroglycerine-induced vasodilation was similar in the 3 groups. The number of and migration of circulating CPCs were similar in the TAO group and control group, whereas the number of and migration of circulating CPCs were significantly lower in the ASO group than in other groups (ASO 553 ± 297/mL versus TAO 963 ± 543/mL; control 1063 ± 426/mL and ASO 36 ± 18/hpf versus TAO 62 ± 23/hpf; control 68 ± 18/hpf, P<0.0001, respectively). There was a significant relationship between the number of and migration of CPCs and FMD (r = 0.43 and r = 0.40, P<0.0001, respectively). FMD was impaired in patients with TAO as well as in patients with ASO compared to that in normal control subjects, and the number of and function of circulating CPCs were not decreased in patients with TAO. These findings may partially explain why there are differences in cardiovascular morbidity and mortality rates between patients with TAO and patients with ASO. PMID:21115876

Idei, Naomi; Nishioka, Kenji; Soga, Junko; Hidaka, Takayuki; Hata, Takaki; Fujii, Yuichi; Fujimura, Noritaka; Maruhashi, Tatsuya; Mikami, Shinsuke; Teragawa, Hiroki; Kihara, Yasuki; Noma, Kensuke; Chayama, Kazuaki; Higashi, Yukihito

2010-11-29

201

An assessment of buoy-derived and numerical weather prediction surface heat fluxes in the tropical Pacific  

Microsoft Academic Search

As part of the Eastern Pacific Investigation of Climate Processes program, from 2000 through 2003, the easternmost 95°W Tropical Atmosphere Ocean (TAO) moorings were enhanced to provide time series of net surface heat flux, and the National Oceanic and Atmospheric Administration ship maintaining the 95°W and 110°W TAO lines was enhanced to monitor surface heat fluxes and atmospheric boundary layer

Meghan F. Cronin; Christopher W. Fairall; Michael J. McPhaden

2006-01-01

202

The Principle of Oneness and Field-Being Philosophy  

Microsoft Academic Search

In this paper, we show the close relationship between Field Being Philosophy and the Basic Theory of Tao Philosophy. The Basic Theory of Tao philosophy is based on the Principle of Oneness. We discuss the synergy of the two formalisms shows another way to appreciate Art of Appropriations. The Field-Being concepts are discussed in terms of the Principle of Oneness.

Wayne L. Wang

203

A case study of wind and sea surface properties at 8°N 95°W  

Microsoft Academic Search

In this study, buoy data from the Tropical Atmosphere Ocean (TAO) array location at 8?N 95?W are analyzed to determine the connection between the atmosphere and ocean. Wind, sea surface temperature (SST), and sea surface salinity (SSS) data from 1994 through 2008 are examined for overall and yearly trends. The TAO buoy at 8?N 95?W is a unique location with

Dawn C. Petraitis; Rex Hervey

2009-01-01

204

Turning Patrons into Partners When Choosing an Integrated Library System  

ERIC Educational Resources Information Center

UCLA, which has one of the top 10 research libraries in the country, has been using Taos software since 1996. However in 2001, Sirsi Corp. announced that it was freezing development on Taos software. As the associate university librarian for information technology at UCLA, the author relates that it was his responsibility to lead the way through…

Ryan, Terry

2004-01-01

205

Matrix isolation infrared spectroscopic and theoretical study of the reactions of tantalum oxide molecules with methanol.  

PubMed

The reactions of tantalum monoxide (TaO) and dioxide (TaO(2)) molecules with methanol in solid neon were investigated by infrared absorption spectroscopy. The ground-state TaO molecule reacted with CH(3)OH in forming the CH(3)OTa(O)H molecule via the hydroxylic hydrogen atom transfer from methanol to the metal center spontaneously on annealing. The observation of the spontaneous reaction is consistent with theoretical predictions that the OH bond activation process is both thermodynamically exothermic and kinetically facile. In contrast, the TaO(2) molecule reacted with CH(3)OH to give primarily the TaO(2)(CH(3)OH) complex, which further rearranged to the CH(3)OTa(O)OH isomer via the hydroxylic hydrogen atom transfer from methanol to one of oxygen atom of metal dioxide upon visible light excitation. PMID:21744863

Wang, Guanjun; Zhuang, Jia; Zhou, Mingfei

2011-07-20

206

Study about correlation of anti-neutrophil cytoplasmic antibodies and anticardiolipin antibodies with thromboangiitis obliterans.  

PubMed

Doctors often have difficulties in clinical diagnosis and clinical stage of thromboangiitis obliterans (TAO). Immunolesion was important in the initiation and progression of various kinds of vasculitis diseases, including TAO. Several kinds of immune complexes were developed by immunolesion, including anti-neutrophil cytoplasmic antibodies (ANCA) and anticardiolipin antibodies (ACA). Our aim was to determine if it is an effective way for clinical diagnosis and clinical stage of TAO by detection of the presence of ANCA and ACA in blood serum of patients with TAO and the relationship among the presence of ANCA, ACA and patients with different grades of TAO. Blood samples and clinical characteristics were collected from 38 patients with Rutherford grade I TAO, 30 patients with Rutherford grade II-III TAO, 75 patients with arteriosclerosis obliterans (ASO) and 65 healthy volunteers. Their serum samples were investigated for ANCA by indirect immunofluorescent (IIF), and for ACA and ANCA specificity antigens including reactivity to proteinase 3(PR3), myeloperoxidase (MPO), cathepsin G (CG), bactericidal/permesbility-increasing protein (BPI), elastase (HLE) and lactoferrin (LF) by enzyme linked immunosorbent assay (ELISA). (1) ANCA positive rate and titre were much higher in cases with Rutherford grade I TAO (52.6%, 20/38, 0.386 ± 0.458) and Rutherford grade II-III TAO (73.3%, 22/30, 0.847 ± 0.658) than those in cases with ASO (4%, 3/75, 0.011 ± 0.002) and healthy volunteers (0%,0/65, 0.010 ± 0.002) (P < 0.01). ANCA positive rate and titre were higher in cases with Rutherford grade II-III TAO (73.3%, 22/30, 0.847 ± 0.658) than those in cases with Rutherford grade I TAO (52.6%, 20/38, 0.386 ± 0.458) (P < 0.05). (2) ACA concentration was much higher in cases with Rutherford grade I TAO (270.13 ± 13.05 IU/mL) and Rutherford grade II-III TAO (279.33 ± 19.98 IU/mL) than that in cases with ASO (236.85 ± 17.32 IU/mL) and healthy volunteers (229.16 ± 15.55 IU/mL) (P < 0.05) respectively. (3) In 42 cases of ANCA-positive samples, there were 20 cases reacted with MPO, 14 cases reacted with LF, five cases reacted with HLE, five cases reacted with BPI and no one reacted with PR3 and CG. All cases were Rutherford grade II-III TAO. Our results indicate that ANCA, ANCA specificity antigens and ACA were detected susceptibly and availably in patients with TAO. Thus, detection of ANCA, ANCA specificity antigens and ACA was helpful for clinical diagnosis of TAO and detection of ANCA and ANCA specificity antigens was helpful for clinical staging of TAO. They are important assistance for clinical diagnosis and stage of TAO. PMID:23493272

Guo, Yi; Dai, Yuanbin; Lai, Junyu; Fan, Ying

2013-03-14

207

X-ray absorption, photoemission spectroscopy, and Raman scattering analysis of amorphous tantalum oxide with a large extent of oxygen nonstoichiometry.  

PubMed

The electronic structure and modification of the local interatomic structure of a reactive sputtered amorphous tantalum oxide (a-TaO(x)) thin film with the variation of oxygen nonstoichiometry, x in a-TaO(x) have been investigated by X-ray absorption spectroscopy (XAS), X-ray photoemission spectroscopy (XPS), Raman scattering spectroscopy, and Rutherford back scattering spectroscopy. A parallel chemical shift of Ta4f(7/2) and O1s core levels observed with the variation of x indicates the Fermi level shift by reduction and oxidation in the framework of the rigid band model. Extended X-ray absorption fine structure (EXAFS) suggests both the increase of average coordination number of the first Ta-O shell in polyhedra and a considerable reduction of the average Ta-O bond length with the increase of x. The relative intensity of Raman shift peaks at 670 cm(-1) and 815 cm(-1), corresponding to Ta-O stretching of TaO(6) octahedra and TaO(5) probably with a pyramidal form, respectively, drastically changes between x = 2.47 to 1.86, suggesting the change in the predominant polyhedron from TaO(6) to TaO(5) with a modification in multiplicity of oxygen by the reorganization of the polyhedral network. PMID:21863188

Tsuchiya, Takashi; Imai, Hideto; Miyoshi, Shogo; Glans, Per-Anders; Guo, Jinghua; Yamaguchi, Shu

2011-08-24

208

Total account ownership. A new model for streamlining your business office staff.  

PubMed

A growing number of medical practices are transforming their payer-based, account follow-up staffing model to total account ownership (TAO). This approach recognizes the equally important tasks of coding, claims transmission, payment posting and refunds, which are usually divided among business office staff. TAO assigns work by payer rather than function. It ensures a fully cross-trained business office and vastly reduces the economic impact of employee absences. In addition, TAO gives every employee approximately the same workload in terms of both quantity and complexity. PMID:17390579

Woodcock, Elizabeth W

2007-01-01

209

Eye findings and immunological markers in probands and their euthyroid relatives from a single family with multiple cases of thyroid autoimmunity  

PubMed Central

Background Ophthalmopathy is a common manifestation of Graves’ disease (GD) occurring in up to 50% of patients. Mild eye signs are also common in patients with Hashimoto’s thyroiditis. Whilst a genetic predisposition to GD has been demonstrated this is not the case for the ophthalmopathy which often runs a separate course. Objective We determined the prevalences of eye and eyelid signs and positive thyroid and orbital antibody tests in first and second degree relatives from a single family with multiple cases of Graves’ disease, ophthalmopathy and Hashimoto’s thyroiditis. Design The study cohort comprised 16 subjects from the same family, 4 probands namely, 3 with GD and one with Hashimoto’s thyroiditis and hypothyroidism and 12 of their euthyroid first or second degree relatives. We measured antibodies against calsequestrin (CASQ1) and collagen XIII in an enzyme-linked-immunosorbent assays and TSH-Receptor (TSH-R) antibodies as i) TSH-R binding inhibiting immunoglobulin (TBII) and ii) thyroid stimulating immunoglobulin (TSI). Eye signs were classified and quantified using the clinical activity score (CAS), NOSPECS classes, Nunery types 1 and 2 and the margin-reflex-distance (MRD) as a measure of upper eyelid retraction (UER). Main outcomes Whilst significant ophthalmopathy was uncommon in the relatives, mild eye signs, in particular UER, were demonstrated in about a third of them. The presence of eye signs was moderately, but not significantly, associated with the detection of CASQ1 and collagen XIII antibodies, but not TSH-R antibodies. Conclusion Our study demonstrates a significant prevalence of positive orbital antibody tests and ophthalmopathy in probands with thyroid autoimmunity and their euthyroid relatives, favouring a role of genetic factors in the development of ophthalmopathy in patients with thyroid autoimmunity.

2012-01-01

210

Solar Heating and Hot Water System Installed at Saint Louis, Missouri.  

National Technical Information Service (NTIS)

The solar heating and hot water system installed at the William Tao & Associates, Inc., office building in St. Louis, Missouri is described, including maintenance and construction problems, final drawings, system requirements, and manufacturer's component...

1980-01-01

211

Solar Heating and Hot Water System Installed at St. Louis, Missouri. Final Report.  

National Technical Information Service (NTIS)

Information is provided on the solar heating and hot water system installed at the William Tao and Associates, Inc., office building in St. Louis, Missouri. The information consists of description, photos, maintenance and construction problems, final draw...

1980-01-01

212

75 FR 9602 - Ocean Transportation Intermediary License; Applicants  

Federal Register 2010, 2011, 2012, 2013

...Applicants Intertrans Express (NY), Inc., 10 East Merrick Road, 203, Valley Stream, NY 11580. Officer: Chun aka Peter T. Tao, President/ Secretary, (Qualifying Individual). International Trade Brokers and Forwarders Co, 2261 NW. 66th...

2010-03-03

213

List of Distributors and Manufacturers Receiving Warning or ...  

Center for Food Safety and Applied Nutrition (CFSAN)

... Tao of Herbs, Inc. Chicago, IL 60616, Now Phase-2 500mg, Now Chitosan with Chromium, Irwin Naturals Maximum Strength Phase 2 Carb Blocker. ... More results from www.fda.gov/food/complianceenforcement/warningletters

214

40 CFR Appendix Vi to Part 264 - Political Jurisdictions 1 in Which Compliance With § 264.18(a) Must Be Demonstrated  

Code of Federal Regulations, 2010 CFR

...Taos Torrance Valencia Utah Beaver Box Elder Cache Carbon Davis Duchesne Emery Garfield Iron Juab Millard Morgan Piute Rich Salt Lake Sanpete Sevier Summit Tooele Utah Wasatch Washington Wayne Weber...

2010-07-01

215

El Nino-La Nina Cross-section of Temperature and Height Anomalies: Jan. 1997 through Febr. 1999  

NSDL National Science Digital Library

An animation of sea surface temperature anomaly, sea surface height anomaly, and sea temperature anomaly at depth in the Pacific Ocean from January 1997 through February 1999 as measured by NOAA AVHRR, TOPEX Poseidon, and the TAO TRITON Array

Shirah, Greg; Busalacchi, Antonio

1999-04-01

216

El Nino Zoom to Cross-section of Temperature and Height Anomalies: September 1997 through July 1998  

NSDL National Science Digital Library

An animation of sea surface temperature anomaly, sea surface height anomaly, and sea temperature anomaly at depth in the Pacific Ocean from September 1997 through July 1998 as measured by NOAA AVHRR, TOPEX Poseidon, and the TAO TRITON Array

Shirah, Greg; Busalacchi, Antonio

1998-07-01

217

El Nino-La Nina Cross-section of Temperature and Height Anomalies: Jan. 1997 through Nov. 1998  

NSDL National Science Digital Library

An animation of sea surface temperature anomaly, sea surface height anomaly, and sea temperature anomaly at depth in the Pacific Ocean from July 1997 through November 1998 as measured by NOAA AVHRR, TOPEX Poseidon, and the TAO TRITON Array

Shirah, Greg; Busalacchi, Antonio

1998-11-23

218

El Nino Zoom to Cross-section of Sea Temperature and Height: January 1997 through March 1998  

NSDL National Science Digital Library

An animation of sea surface temperature, sea surface height, and sea temperature at depth in the Pacific Ocean from January 1997 through March 1998 as measured by NOAA AVHRR, TOPEX Poseidon, and the TAO TRITON Array

Shirah, Greg; Busalacchi, Antonio

1998-03-20

219

El Nino-La Nina Cross-section of Temperature and Height Anomalies: Jan. 1997 through Dec. 1999  

NSDL National Science Digital Library

An animation of sea surface temperature anomaly, sea surface height anomaly, and sea temperature anomaly at depth in the Pacific Ocean from January 1997 through December 1999 as measured by NOAA AVHRR, TOPEX Poseidon, and the TAO TRITON Array

Shirah, Greg; Busalacchi, Antonio

1999-12-21

220

El Nino-La Nina Cross-section of Sea Temperature and Height: July 1997 through November 1998  

NSDL National Science Digital Library

An animation of sea surface temperature, sea surface height, and sea temperature at depth in the Pacific Ocean from July 1997 through November 1998 as measured by NOAA AVHRR, TOPEX Poseidon, and the TAO TRITON Array

Shirah, Greg; Busalacchi, Antonio

1998-11-23

221

El Nino-La Nina Cross-section of Temperature and Height Anomalies: January 1997 through March 1999  

NSDL National Science Digital Library

An animation of sea surface temperature anomaly, sea surface height anomaly, and sea temperature anomaly at depth in the Pacific Ocean from January 1997 through March 1999 as measured by NOAA AVHRR, TOPEX Poseidon, and the TAO TRITON Array

Shirah, Greg; Busalacchi, Antonio

1999-04-01

222

El Nino Zoom to Cross-section of Temperature and Height Anomalies: July 1997 through August 1998  

NSDL National Science Digital Library

An animation of sea surface temperature anomaly, sea surface height anomaly, and sea temperature anomaly at depth in the Pacific Ocean from July 1997 through August 1998 as measured by NOAA AVHRR, TOPEX Poseidon, and the TAO TRITON Array

Shirah, Greg; Busalacchi, Antonio

1998-08-20

223

El Nino-La Nina Zoom to Cross-section of Temperature and Height Anomalies: Jan. 1997 through Nov. 1998  

NSDL National Science Digital Library

An animation of sea surface temperature anomaly, sea surface height anomaly, and sea temperature anomaly at depth in the Pacific Ocean from January 1997 through November 1998 as measured by NOAA AVHRR, TOPEX Poseidon, and the TAO TRITON Array

Shirah, Greg; Busalacchi, Antonio

1998-11-23

224

40 CFR 81.239 - Upper Rio Grande Valley Intrastate Air Quality Control Region.  

Code of Federal Regulations, 2012 CFR

...geographically located within the outermost boundaries of the area so delimited): In the State of New Mexico: Los Alamos County, Santa Fe County, Taos County. Those portions of Rio Arriba County lying east of the Continental...

2012-07-01

225

Trinidad Reservoir Salvage Archaeology, 1970. Sites: TC:C9:9B, TC:C9:23, TC:C9:24, TC:C9:302.  

National Technical Information Service (NTIS)

Excavation of four sites with architectural elements in conjunction with the Trinidad COE Reservoir project. Sites exhibited ceramics from the Taos region of New Mexico and the western Oklahoma area. (Author)

S. K. Ireland

1973-01-01

226

Warning Letter: HMS King's Crown  

Center for Drug Evaluation (CDER)

Text Version... 332 Kit Carson Road 6457 NDCBU Taos, NM 87571 Ms Susan Turner, Webmaster HMS Crown 550 Vista Drive Ridgeway, CO 8 1432 ... More results from www.fda.gov/downloads/drugs/guidancecomplianceregulatoryinformation

227

7 CFR 407.10 - Group risk plan for barley.  

Code of Federal Regulations, 2013 CFR

...thereof; all New Mexico counties except Taos County; Kansas; Missouri; Illinois; Indiana; Ohio; Pennsylvania; New York; Massachusetts...states except: Arizona, California, and (except) Kansas, Missouri, Illinois, Indiana, Ohio, Pennsylvania, New York,...

2013-01-01

228

Materials, Devices, and Circuits of Transparent Amorphous-Oxide Semiconductor  

Microsoft Academic Search

This paper presents the following recent investigations of transparent amorphous-oxide semiconductors (TAOS) from materials to devices and circuits. 1) Composition of metals in TAOS are widely explored with the aim of seeking semiconductors suitable for the channel layers of thin-film transistors (TFTs) composing backplanes for flat-panel displays. It is found in combinatorial approaches to the materials exploration that indium-based ternary

Hideya Kumomi; Seiichiro Yaginuma; Hideyuki Omura; Amita Goyal; Ayumu Sato; Masaya Watanabe; Mikio Shimada; Nobuyuki Kaji; Kenji Takahashi; Masato Ofuji; Tomohiro Watanabe; Naho Itagaki; Hisae Shimizu; Katsumi Abe; Yoshinori Tateishi; Hisato Yabuta; Tatsuya Iwasaki; Ryo Hayashi; Toshiaki Aiba; Masafumi Sano

2009-01-01

229

Exophthalmos: A Forgotten Clinical Sign of Cushing's Syndrome  

PubMed Central

Exophthalmos is typically associated with Graves' ophthalmopathy. Although originally described by Harvey Cushing, exophthalmos is an underappreciated sign of Cushing's syndrome. We present a case of a 38-year-old female who presented with severe bilateral proptosis and was subsequently diagnosed with Cushings disease. We discuss the possible mechanisms causing exophthalmos in patients with either endogenous or exogenous hypercortisolemia.

Giugni, Aldo Schenone; Mani, Shylaja; Kannan, Subramanian

2013-01-01

230

Stimulation of Adipogenesis, Peroxisome Proliferator- Activated Receptor (PPAR), and Thyrotropin Receptor by PPAR Agonist in Human Orbital Preadipocyte Fibroblasts  

Microsoft Academic Search

The symptoms and signs of Graves' ophthalmopathy (GO) re- sult from both an accumulation of hydrated hyaluronan in the orbital muscles and connective tissues and an expansion of the orbital adipose tissues. Recent studies have suggested a link between the stimulation of adipogenesis within the orbit in GO and the expression in these tissues of TSH receptor (TSHR), the putative

ROSANEE W. VALYASEVI; DEBRA A. HARTENECK; CHARYL M. DUTTON; REBECCA S. BAHN

231

Triad of exophthalmos, pretibial myxedema, and acropachy in a patient with Graves' disease  

Microsoft Academic Search

Graves' disease is an autoimmune disorder of the thyroid gland with characteristic peripheral manifestations. The most common clinical findings include ophthalmopathy in 30% of patients, dermopathy (pretibial myxedema) in 4% of patients, and thyroid acropachy in 1% of patients. The triad of exophthalmos, pretibial myxedema, and acropachy occurs in less than 1% of patients. We present a case of Graves'

Christina K. Anderson; O. Fred Miller

2003-01-01

232

Clinical scoring scales in thyroidology: A compendium  

PubMed Central

This compendium brings together traditional as well as contemporary scoring and grading systems used for the screening and diagnosis of various thyroid diseases, dysfunctions, and complications. The article discusses scores used to help diagnose hypo-and hyperthyroidism, to grade and manage goiter and ophthalmopathy, and to assess the risk of thyroid malignancy.

Kalra, Sanjay; Khandelwal, Sachin K.; Goyal, Aakshit

2011-01-01

233

Ophthalmic Manifestations of Leukemia in a Tertiary Hospital Population of Adult Nigerian Africans  

PubMed Central

Purpose: To determine the prevalence and pattern of leukemic ophthalmopathy among adults at the University of Nigeria Teaching Hospital (UNTH), Enugu, south-eastern, Nigeria. Materials and Methods: This prospective, observational case series surveyed adult leukemia patients presenting at UNTH’s departments of Hematology/Immunology and Ophthalmology from July 2003 to August 2008. The demographic profile, clinical data from for each individual in the cohort were statistically collated and analyzed. A P <0.05 was considered as statistically significant. Results: There were 72 participants (45 males and 27 females), aged 32.7 ± 9.8 years (range, 18 years to 72 years). Leukemic ophthalmopathy was present in 77.8% of subjects. The leading ophthalmic manifestations of leukemia were retinal vascular abnormalities in 50.0% of subjects, conjunctival pallor in 27.8% of subjects, sub-conjunctival hemorrhage in 19.4% of subjects, and retinal hemorrhage in 16.7% of subjects. Ocular co-morbidity was present in 47.2% of subjects. Vision loss occurred in 37.5% of subjects, of which 32.1% was leukemia related, and the remaining due to ocular co-morbidity. Leukemic ophthalmopathy was more prevalent in chronic leukemia (P <0.05), frequently affected the ocular posterior segment (P < 0.05), and often resulted from secondary hematologic complications (P <0.05). There was no gender difference in the prevalence of leukemia (P = 0.0822) or leukemic ophthalmopathy (P = 0.6624). Conclusion: The prevalence of leukemic ophthalmopathy in Enugu is high. It is often associated with significant ocular co-morbidity and vision loss. These have implications for clinicians involved in leukemia management. Early diagnosis and regular ophthalmic examinations are recommended to optimize treatment outcomes.

Eze, Boniface I.; Ibegbulam, Godswill O.; Ocheni, Sunday

2010-01-01

234

Molecular electronics and spintronics devices produced by the plasma oxidation of photolithographically defined metal electrode  

NASA Astrophysics Data System (ADS)

Tunnel junction based molecular devices, which utilize the two metal electrodes of a metal-insulator-metal tunnel junction as the two electrical leads to connect with molecular channels, can overcome the long standing fabrication challenges for developing futuristic molecular devices. However, producing an ultrathin insulator is the most challenging step in this tunnel junction based molecular device fabrication. A simplified molecular device approach was developed by avoiding the need of depositing a new material on the bottom electrode for growing ultrathin insulator. This paper discusses the new approach for insulator growth by one-step oxidation of a tantalum (Ta) bottom electrode, in the pholithographically defined region, i.e., ultrathin tantalum oxide (TaO x ) insulator was grown by oxidizing bottom Ta metal electrode itself. Organometallic molecular clusters (OMCs) were bridged across 1-3 nm TaO x along the perimeter of a tunnel junction to establish the highly efficient molecular conduction channels. OMC transformed the asymmetric transport profile of TaO x based tunnel junction into symmetric one. A TaO x based tunnel junction with the top ferromagnetic (NiFe) electrode exhibited the transient current suppression by several orders. Further studies by independent research groups will be needed to strengthen the current suppression phenomenon, and to realize the full potential of TaO x based molecular devices.

Tyagi, Pawan

2012-09-01

235

Crystallization and preliminary crystallographic analysis of cyanide-insensitive alternative oxidase from Trypanosoma brucei brucei.  

PubMed

Cyanide-insensitive alternative oxidase (AOX) is a mitochondrial membrane protein and a non-proton-pumping ubiquinol oxidase that catalyzes the four-electron reduction of dioxygen to water. In the African trypanosomes, trypanosome alternative oxidase (TAO) functions as a cytochrome-independent terminal oxidase that is essential for survival in the mammalian host; hence, the enzyme is considered to be a promising drug target for the treatment of trypanosomiasis. In the present study, recombinant TAO (rTAO) overexpressed in haem-deficient Escherichia coli was purified and crystallized at 293 K by the hanging-drop vapour-diffusion method using polyethylene glycol 400 as a precipitant. X-ray diffraction data were collected at 100 K and were processed to 2.9 A resolution with 93.1% completeness and an overall R(merge) of 9.5%. The TAO crystals belonged to the orthorhombic space group I222 or I2(1)2(1)2(1), with unit-cell parameters a = 63.11, b = 136.44, c = 223.06 A. Assuming the presence of two rTAO molecules in the asymmetric unit (2 x 38 kDa), the calculated Matthews coefficient (V(M)) was 3.2 A(3) Da(-1), which corresponds to a solvent content of 61.0%. This is the first report of a crystal of the membrane-bound diiron proteins, which include AOXs. PMID:20208159

Kido, Yasutoshi; Shiba, Tomoo; Inaoka, Daniel Ken; Sakamoto, Kimitoshi; Nara, Takeshi; Aoki, Takashi; Honma, Teruki; Tanaka, Akiko; Inoue, Masayuki; Matsuoka, Shigeru; Moore, Anthony; Harada, Shigeharu; Kita, Kiyoshi

2010-02-24

236

A simple shape-free model for pore-size estimation with positron annihilation lifetime spectroscopy  

NASA Astrophysics Data System (ADS)

Positron annihilation lifetime spectroscopy is one of the methods for estimating pore size in insulating materials. We present a shape-free model to be used conveniently for such analysis. A basic model in classical picture is modified by introducing a parameter corresponding to an effective size of the positronium (Ps). This parameter is adjusted so that its Ps-lifetime to pore-size relation merges smoothly with that of the well-established Tao-Eldrup model (with modification involving the intrinsic Ps annihilation rate) applicable to very small pores. The combined model, i.e., modified Tao-Eldrup model for smaller pores and the modified classical model for larger pores, agrees surprisingly well with the quantum-mechanics based extended Tao-Eldrup model, which deals with Ps trapped in and thermally equilibrium with a rectangular pore.

Wada, Ken; Hyodo, Toshio

2013-06-01

237

Tropical atmosphere ocean array-update  

SciTech Connect

Developed as a key component of the recently completed 10-year (1985-1994) international Tropical Ocean Global Atmosphere (TOGA) program, the Tropical Atmosphere Ocean (TAO) array expanded in size from seven moorings in early 1985 to 69 moorings upon completion in December 1994. Spanning one-third of the circumference of the globe, surface buoys are moored every 2 to 3 degrees of latitude. The TAO array measures oceanographic and surface meteorological variables critical for improved detection, understanding, and prediction of seasonal to interannual climate variations originating in the tropics, most notably those related to the El Nino/Southern Oscillation. With the completion of TOGA, new national and international research programs have been formulated to build on the successes of TOGA. Continued maintenance of the TAO array and other components of the TOGA observing system is key to the success of these new climate research programs.

Freitag, H.P.; Mangum, L.J. [Univ. of Washington, Seattle, WA (United States); McPhaden, M.J. [Pacific Marine Environmental Lab., Seattle, WA (United States)

1995-10-01

238

Aitken extrapolation and epsilon algorithm for an accelerated solution of weakly singular nonlinear Volterra integral equations  

NASA Astrophysics Data System (ADS)

In this paper, we apply Aitken extrapolation and epsilon algorithm as acceleration technique for the solution of a weakly singular nonlinear Volterra integral equation of the second kind. In this paper, based on Tao and Yong (2006 J. Math. Anal. Appl. 324 225-37.) the integral equation is solved by Navot's quadrature formula. Also, Tao and Yong (2006) for the first time applied Richardson extrapolation to accelerating convergence for the weakly singular nonlinear Volterra integral equations of the second kind. To our knowledge, this paper may be the first attempt to apply Aitken extrapolation and epsilon algorithm for the weakly singular nonlinear Volterra integral equations of the second kind.

Mesgarani, H.; Aghazadeh, N.; Parmour, P.

2010-02-01

239

[Traditional Chinese medicine in urology.  

PubMed

Traditional Chinese medicine (TCM) is an ancient holistic medicine based on the doctrine of Tao and Qi. Tao represents an alteration from which the polarity of Yin and Yang arises and Qi is the vitality which circulates through the body. Therapeutic concepts of TCM include acupuncture, herbal therapy, nutrition and Tuina, a form of manual therapy. TCM is now gaining increased acceptance in the Western society as a complementary therapy. Acupuncture and herbal therapy are the main forms of implementation of TCM in urology. PMID:23754610

Hüsch, T; Tsaur, I; Reiter, M; Mager, R; Haferkamp, A

2013-06-12

240

Associated autoantibodies in celiac disease  

Microsoft Academic Search

Celiac disease (CD) is a life-long inflammatory autoimmune condition of the gastrointestinal tract affecting genetically susceptible individuals. Several autoimmune disorders are more prevalent in patients and their close relatives and that risk is gluten exposure duration related. The most frequent reported CD associated conditions are type 1 diabetes mellitus and autoimmune thyroiditis. Associated autoimmune antibodies are frequent in CD and

Ron Shaoul; Aaron Lerner

2007-01-01

241

[Postoperative treatment of differentiated thyroid carcinoma with intermediate recurrence risk].  

PubMed

The three-level recurrence stratification of differentiated thyroid carcinoma(DTC)has attracted wide attention since its introduction in 2009 American Thyroid Association guidelines.Among these three levels,the postoperative treatment of DTC with intermediate recurrence risk is highly controversial.This article summarizes the relevant advances and controversies in this field. PMID:23987482

Yang, Xue; Lin, Yan-song

2013-08-01

242

Hashimoto's thyroiditis revisited: The association with thyroid cancer remains obscure  

Microsoft Academic Search

Hashimoto's thyroiditis (HT) is an autoimmune disease of the thyroid associated with goiter and hypothyroidism. Although there exists a clear association between HT and lymphomas of the thyroid, the association between HT and thyroid cancer remains unclear. To evaluate this further, we retrospectively reviewed the pathology reports for all thyroidectomy specimens as well as the records of patients admitted to

Michael K. McLeod; Mary E. East; Richard E. Burney; Jay K. Harness; Norman W. Thompson

1988-01-01

243

Surgical Treatment of Graves’ Disease: Evidence-Based Approach  

Microsoft Academic Search

Background  The optimal treatment of Graves´ disease (GD) is still controversial. Surgery is one treatment option along with radioactive\\u000a iodine (RAI) and antithyroid medication. In this evidence-based review, we examine four issues: (1) Is surgery better than\\u000a RAI or long-term antithyroid medication? (2) What is the recommended surgical approach? (3) How does the presence of Graves’\\u000a ophthalmopathy (GO) influence the role

Peter Stålberg; Anna Svensson; Ola Hessman; Göran Åkerström; Per Hellman

2008-01-01

244

Flashing lights in thyroid eye disease: a new symptom described and (possibly) explained  

Microsoft Academic Search

BACKGROUND\\/AIMSSome patients with restrictive thyroid ophthalmopathy, referred for consideration of extraocular muscle surgery, complained of flashing lights in the superior visual field on upgaze. The frequency was assessed and the pathogenesis of this previously unreported symptom explored.METHODS30 patients were recruited, all of whom had tight inferior recti and were in the burnt out phase of thyroid eye disease. They were

Jenny J Danks; Richard A Harrad

1998-01-01

245

Clinical Variability of Stickler Syndrome  

Microsoft Academic Search

Stickler syndrome (progressive arthro-ophthalmopathy) is a genetically heterogeneous disorder resulting from mutations in at least three collagen genes. The most common disease-causing gene is COL2A1, a 54-exon–containing gene coding for type II collagen. At least 17 different mutations causing Stickler syndrome have been reported in this gene. Phenotypically, it is also a variably expressed disorder in which most patients present

Larry A Donoso; Albert O Edwards; Arcilee T Frost; Robert Ritter; Nina Ahmad; Tamara Vrabec; Jerry Rogers; David Meyer; Scott Parma

2003-01-01

246

75 FR 33299 - Environmental Impacts Statements; Notice Of Availability  

Federal Register 2010, 2011, 2012, 2013

...Period Ends: 07/12/ 2010, Contact: Bob Ross 703-602-2878. EIS No. 20100209...Lands and Resource Administered by Taos Field Office, Colfax, Harding, Los Alamos...Avenue/1860 South Interchange to 3110 West Street in Provo, UT, Comment Period...

2010-06-11

247

Treatment of thromboangiitis obliterans (Buerger's disease) by intramuscular gene transfer of vascular endothelial growth factor: Preliminary clinical results  

Microsoft Academic Search

Purpose: Thromboangiitis obliterans (TAO), or Buerger's disease, a distinct form of vascular occlusive disease that afflicts the peripheral arteries of young smokers, is often characterized by an inexorable downhill course even in patients who discontinue smoking once a stage of critical limb ischemia associated with ulceration or gangrene is reached. As part of a phase I clinical trial to document

Jeffrey M. Isner; Iris Baumgartner; Guenter Rauh; Robert Schainfeld; Richard Blair; Orit Manor; Syed Razvi; James F. Symes

1998-01-01

248

Degradation of endocrine disrupting bisphenol A during pre-treatment and biotransformation of wastewater sludge  

Microsoft Academic Search

The effect of various pre-treatment methods, including alkaline hydrolysis (AH), thermal hydrolysis (TH), thermal alkaline hydrolysis (TAH), thermal oxidation (TO) and thermal alkaline oxidation (TAO), on solubilization and simultaneous degradation of bisphenol A (BPA), an endocrine disruptor, in wastewater sludge (WWS) were investigated. The results showed that among AH, TH and TAH pre-treatments, TAH significantly improved the solubilization of WWS

D. P. Mohapatra; S. K. Brar; R. D. Tyagi; R. Y. Surampalli

2010-01-01

249

Watch It  

ERIC Educational Resources Information Center

For the school chief information officer (CIO), safeguarding students and facilities is as much a part of the job description as keeping the data networks running and the servers protected from hackers. This article describes how two districts, Miami-Dade County Public Schools and Taos Municipal Schools, secured their surveillance systems. The…

Bolch, Matt

2008-01-01

250

Taoist Lessons for Educational Leaders: Gentle Pathways to Resolving Conflicts  

ERIC Educational Resources Information Center

This book explores ways in which educational leaders can apply the wisdom of the Tao in their day-to-day work in schools. It offers an alternative to the standard ways of western thinking to give the leader more possibilities when confronting a situation. We tend to value immediate and decisive action, winning, directing, and getting one's way.…

Heller, Daniel

2012-01-01

251

Energy Management Study for General Leonard Wood Army Community Hospital.  

National Technical Information Service (NTIS)

William Tao Associates, Inc. (WTA) was commissioned by the United States Army Corps of Engineers (COE) to perform an Energy Management Study of the General Leonard Wood Army Community Hospital (GLWACH). The Hospital is a 366,000 SF facility, with schedule...

1986-01-01

252

Applying Fractal and Chaos Theory to Animation in the Chinese Literati Tradition  

Microsoft Academic Search

This paper describes and tests the hypothesis that that which ancient Chinese philosophy searched for, the Tao, is the same principle as that found in modern Chaos and Fractal Theories. An elucidation of several key principles and notions of Chinese art theory is offered, coupled with fractal notions from Chaos theory. It is argued that Chinese art is an abstract

Qing Huang; Ronald J. Balsys

2009-01-01

253

Different Perspectives of Cultural Mediation: Implications for the Research Design on Studies Examining Its Effect on Students' Cognition  

ERIC Educational Resources Information Center

|In this forum, I extend Tao, Oliver, and Venville's paper "Chinese and Australian children's understanding of the earth: a cross cultural study of conceptual development" to discuss the different views on culture and cultural mediation. I tease out nuances in the viewpoints to suggest three ways to theoretically frame studies examining cultural…

Teo, Tang Wee

2013-01-01

254

An Inventory of Natural, Human, and Social Overhead Capital Resources in North-Central New Mexico.  

ERIC Educational Resources Information Center

Concerned with the north-central area of New Mexico (Rio Arriba, Taos, Colfax, Mora, Santa Fe, and San Miguel counties), this inventory describes the situation and delineation of the region, the natural resources (physical characteristics, land, land-ownership patterns, land-use patterns, land-title problems, water resources, and minerals); human…

Carruthers, Garrey; Eastman, Clyde

255

Cultural Issues of School Dropouts in Hong Kong  

ERIC Educational Resources Information Center

|Despite the 150 years of British colonial governance in Hong Kong, Chinese collectivist culture continues to be a dominant source of influence in the learning context of students (Cheng, 1998; Salili, Lai and Leung, 2004; Tao and Hong, 2000), placing a great emphasis on education and effort (Salili and Lai, 2003). Education is viewed as the…

Lau, Yuk King; Tsang, Bill Y. P.; Kwok, Diana K.

2007-01-01

256

Implementing Condition Variables with Semaphores  

Microsoft Academic Search

In 1984 a group of us at DEC SRC were implementing a new multi-processor operating system: the system was Taos, the machine was Firefly and the language, which we created, was Modula-2+. As part of that effort we implemented these threads primitives. In doing so we observed that the semantics of Acquire and Release were identical to those of a

Andrew D. Birrell

257

Watch It  

ERIC Educational Resources Information Center

|For the school chief information officer (CIO), safeguarding students and facilities is as much a part of the job description as keeping the data networks running and the servers protected from hackers. This article describes how two districts, Miami-Dade County Public Schools and Taos Municipal Schools, secured their surveillance systems. The…

Bolch, Matt

2008-01-01

258

We Shared the Same Chapter: Collaboration, Learning, and Transformation from the 2008 Subsistence, the Environment, and Community Well-Being Native Youth Exchange in Old Harbor, Alaska Project  

ERIC Educational Resources Information Center

|On a small island belonging to the Alutiiq people of Old Harbor, 11 people sat around a campfire. Two community leaders, a nonprofit organizer, an academic scholar, a native filmmaker, and six young people from the Indian reservation of Taos Pueblo in New Mexico gathered after a day of interacting with Old Harbor residents--fishing, hunting and…

Richmond, Laurie; Di Piero, Daniela; Espinoza, Flowers; Simeonoff, Teacon; Faraday, Margaret

2010-01-01

259

Islam, Gender, and Formal Shari'a in Indonesia  

Microsoft Academic Search

The above remark is cited by Annemarie Schimmel in her foreword to The Tao of Islam (Murata 1992, vii). Winternitz' observation is particularly evident when put in the context of Islam, as Schimmel contends that 'it is certainly easier to look only at the surface … of polygamy and easy divorce and … purdah … than to try to see

Lily Zakiyah Munir

260

A crescent-shaped low-level jet as observed by a Doppler radar  

Microsoft Academic Search

Background Encountered in many parts of the world, low- level jets (LLJs) have attracted considerable attention because of their relation to thunder- storm development, cyclogenesis, air pollution and aviation safety. In south China, studies of LLJs have mostly focused on their role in con- nection with summer monsoon rain (Tao and Chen 1987; Chen et al. 1994; Chen and Chen

S. Y. Lau; S. T. Chan

2003-01-01

261

Colloidal unilamellar layers of tantalum oxide with open channels.  

PubMed

Layered tantalum oxide, RbTaO3, was delaminated into colloidal TaO3 unilamellar crystallites, which are characterized by an open-channel structure as well as a very small thickness of approximately 1.0 nm. PMID:17497774

Fukuda, Katsutoshi; Nakai, Izumi; Ebina, Yasuo; Ma, Renzhi; Sasaki, Takayoshi

2007-05-11

262

ENGLISH LEARNING STRATEGY USE BY ELEMENTARY SCHOOL STUDENTS  

Microsoft Academic Search

This study investigates the effects of gender, parents' education level and learning experience out of school on English learning strategy use. The subjects are 82 sixth grade elementary school students in Tao-Yuan county. The instrument is an English learning questionnaire modified from Oxford's Strategy Inventory for Language Learning. According to the results, the elementary school students do use learning strategies

Shiu-chen Hsu

263

Tropical Atmosphere Ocean Project: El Nino and La Nina 3-D Visualizations  

NSDL National Science Digital Library

Users can view a selection of animations of ocean surface temperature and dynamic height derived from data from the TAO/TRITON buoy array moored in the Pacific Ocean. The animations show temperature and surface topography variations consistent with the development of El Nino and La Nina events.

264

77 FR 7184 - Entergy Nuclear Indian Point 2, LLC; Entergy Nuclear Operations, Inc.; Indian Point Nuclear...  

Federal Register 2010, 2011, 2012, 2013

...and 23A to alternate power...breakers 52/ Room, Turbine 5A and 52-SAC Building...Building, TAO at Bus 6A Nuclear Service and remove Building, control power Chemical fuses. Systems...Screenwell House, and Unit 2 Turbine...

2012-02-10

265

THE TAIWANESE-AMERICAN OCCULTATION SURVEY PROJECT STELLAR VARIABILITY. II. DETECTION OF 15 VARIABLE STARS  

SciTech Connect

The Taiwanese-American Occultation Survey (TAOS) project has collected more than a billion photometric measurements since 2005 January. These sky survey data-covering timescales from a fraction of a second to a few hundred days-are a useful source to study stellar variability. A total of 167 star fields, mostly along the ecliptic plane, have been selected for photometric monitoring with the TAOS telescopes. This paper presents our initial analysis of a search for periodic variable stars from the time-series TAOS data on one particular TAOS field, No. 151 (R.A. = 17{sup h}30{sup m}6.{sup s}7, decl. = 27{sup 0}17'30'', J2000), which had been observed over 47 epochs in 2005. A total of 81 candidate variables are identified in the 3 deg{sup 2} field, with magnitudes in the range 8 < R < 16. On the basis of the periodicity and shape of the light curves, 29 variables, 15 of which were previously unknown, are classified as RR Lyrae, Cepheid, {delta} Scuti, SX Phonencis, semi-regular, and eclipsing binaries.

Mondal, S.; Lin, C. C.; Chen, W. P.; Zhang, Z.-W.; Lin, H.-C. [Institute of Astronomy, National Central University, 300 Jhongda Road, Jhongli 32054, Taiwan (China); Alcock, C.; Bianco, F. B.; Lehner, M. J.; Protopapas, P. [Harvard-Smithsonian Center for Astrophysics, 60 Garden Street, Cambridge, MA 02138 (United States); Axelrod, T. [Steward Observatory, 933 North Cherry Avenue, Room N204, Tucson, AZ 85721 (United States); Byun, Y.-I.; Kim, D.-W. [Department of Astronomy, Yonsei University, 134 Shinchon, Seoul 120-749 (Korea, Republic of); Coehlo, N. K.; Rice, J. A. [Department of Statistics, University of California Berkeley, 367 Evans Hall, Berkeley, CA 94720 (United States); Cook, K. H.; Marshall, S. L. [Institute for Geophysics and Planetary Physics, Lawrence Livermore National Laboratory, Livermore, CA 94550 (United States); Dave, R. [Initiative in Innovative Computing at Harvard, 120 Oxford Street, Cambridge, MA 02138 (United States); King, S.-K.; Lee, T. [Institute of Astronomy and Astrophysics, Academia Sinica, P.O. Box 23-141, Taipei 106, Taiwan (China); Schwamb, M. E., E-mail: soumen@aries.res.i [Division of Geological and Planetary Sciences, California Institute of Technology, 1201 East California Boulevard, Pasadena, CA 91125 (United States)

2010-05-15

266

Group Counseling With Emotionally Disturbed School Children in Taiwan.  

ERIC Educational Resources Information Center

|The application of group counseling to emotionally disturbed school children in Chinese culture was examined. Two junior high schools located in Tao-Yuan Province were randomly selected with two eighth-grade classes randomly selected from each school. Ten emotionally disturbed students were chosen from each class and randomly assigned to two…

Chiu, Peter

267

Spherical Averaged Endpoint Strichartz Estimates for The Two-dimensional Schrodinger Equations with Inverse Square Potential  

Microsoft Academic Search

The endpoint Strichartz estimates for two-dimensional Schrodinger equations were recovered by averaging the solutions in L^2 in the angular variable by Tao. For Schrodinger equations with defocusing inverse square potential, we proved that the homogeneous endpoint estimates hold under this setting. In particular, the original versions of endpoint estimates hold for radial data.

I-Kun Chen

2008-01-01

268

Comparison of ocean surface vector winds observed by SeaWinds on ADEOS-II with ocean buoy data  

Microsoft Academic Search

Wind vectors observed by SeaWinds on ADEOS-II are compared with wind and wave data from offshore moored buoys. The wind data were collocated with buoy observations operated by the National Data Buoy Center (NDBC), Tropical Atmosphere Ocean (TAO), and Pilot Research Moored Array in the Tropical Atlantic (PIRATA) projects. Only buoys located offshore and in deep water were selected. Temporal

Naoto Ebuchi; Hans C. Graber; Michael J. Caruso

2004-01-01

269

Transaortic access is the key to success.  

PubMed

Transcatheter aortic valve implantation (TAVI) using either the Edwards SAPIEN Valve or Medtronic CoreValve is a well-established procedure. Although initially carried out through transfemoral and transapcial approaches, alternative approaches have become popular and have been utilised to optimise the outcomes. The transaortic (TAo) approach can be used for both these devices and is carried out through the ascending aorta, which can be approached through a partial upper J-sternotomy, T-sternotomy or a right anterior thoracotomy. Due to its familiarity, this procedure is within the comfort zone of surgeons which reduces the learning curve as well as access site-related complications. There are also other potential advantages to the TAo approach, which make it versatile and less invasive. These advantages, indications, contraindications, surgical technique and results will be discussed in this paper. The ongoing ROUTE registry (SAPIEN multicentre European TAo registry), prospective CoreValve multicentre European registry and data from a pivotal trial for CoreValve in the United States will certainly provide robust data in confirming the various advantages seen in centres utilising this approach. Dedicated TAo delivery systems, which could also be used for the subclavian approach, are on the horizon for the newer devices which are currently implanted through other approaches. PMID:24025954

Bapat, Vinayak N; Bruschi, Giuseppe

2013-09-10

270

Hybrid Slip Model for Predicting Near-field Strong Ground Motion  

Microsoft Academic Search

A hybrid slip model combined an Asperity model and k-2 model for predicting near-field strong ground motion is proposed in this paper. Firstly, the asperity model charactering lower wave number of slip distribution is estimated based on works of Wang (2004), Wang and Tao (2004a, b). Secondly, k square slip model charactering higher wave number of slip distribution was determined

Haiyun Wang; Xiaxin Tao

271

Treesearch - Forest Service Research & Development  

Treesearch

to mountain pine beetle, Dendroctonus ponderosae Hopkins, attack in uneven- aged stands ... Smith, Douglas R.; Quinlan, Aaron R.; Peckham, Heather E.; Makowsky, Kathryn; Tao, ... William F.; Tusneem, Nadeem; Stromberg, Michael P. ; Stewart, Donald A.; Zhang, Lu; Ranade, Swati S.; Warner, Jason B.; Lee, Clarence C.; ...

272

Emphasis on Interpersonal Factors in a Dynamic Model of Relapse  

ERIC Educational Resources Information Center

This article presents comments on "Relapse Prevention Needs More Emphasis on Interpersonal Factors" by Stanton which is a comment on the original article "Relapse Prevention for Alcohol and Drug Problems: That Was Zen, This Is Tao" by Katie Witkiewitz and G. Alan Marlatt. In the current comment the authors of the original article respond to…

Witkiewitz, Katie; Marlatt, G. Alan

2005-01-01

273

Relapse Prevention Needs More Emphasis on Interpersonal Factors  

ERIC Educational Resources Information Center

This article presents comments on "Relapse Prevention for Alcohol and Drug Problems: That Was Zen, This Is Tao," by Katie Witkiewitz and G.A. Marlatt. Stanton notes that the recent reconceptualization of relapse prevention by Witkiewitz and Marlatt enhances the model by "synthesizing recent empirical findings into a unified theory", but it does…

Stanton, Mark

2005-01-01

274

On the norm convergence of nonconventional ergodic averages  

Microsoft Academic Search

We offer a generalization of the recent result of Tao (building on earlier results of Conze and Lesigne, Furstenberg and Weiss, Zhang, Host and Kra, Frantzikinakis and Kra and Ziegler) that the nonconventional ergodic averages associated to an arbitrary number of commuting probability-preserving transformations always converge to some limit in L^2. We prove the corresponding result for a collection of

Tim Austin

2008-01-01

275

78 FR 18783 - Establishment of the R[iacute]o Grande del Norte National Monument  

Federal Register 2010, 2011, 2012, 2013

...and Scenic River flows through a deep gorge at the edge of the stark and sweeping expanse of the Taos Plateau. Volcanic cones...a center of research in geology and volcanology. Rising in stark contrast from the plateau's broad expanse, Cerro de la...

2013-03-28

276

The Pueblo Indians of New Mexico: An Analysis of the Educational System.  

ERIC Educational Resources Information Center

Educational systems (both tribal and formal) of the Pueblo Indians, including Taos, San Juan, Tesuque, Zia, Zuni, and the Bernalillo District in New Mexico, were analyzed. The analysis included discerning whether or not (1) the Pueblos' traditional culture and heritage is being taught and to what extent and (2) bilingual and bicultural studies…

Cibrario, Dominic J.

277

A Comparative Sketch of Pueblo Languages: Phonology.  

ERIC Educational Resources Information Center

|In an attempt to determine some of the shared phonological traits among Pueblo Indians of the American Southwest, this paper compares the sound systems of Pueblo languages. The languages within the scope of this research are Zuni, Keresan (Acoma and Santa Ana), and Tanoan (Sandia, Taos, Jemez, and Santa Clara). It is noted that Pueblo Indians…

Yumitani, Yukihiro

278

The Role of Discursive Resources in Science Talk  

ERIC Educational Resources Information Center

|Tao, Oliver, and Venville's paper addresses a debate between two hypotheses of children's development of conceptual understandings of the Earth. The authors aim to investigate whether culture influences students' conceptions of the Earth. However, one questionable assumption shared among conception and conceptual change studies is that…

Hsu, Pei-Ling

2013-01-01

279

THE TAIWAN-AMERICAN OCCULTATION SURVEY PROJECT STELLAR VARIABILITY. I. DETECTION OF LOW-AMPLITUDE {delta} SCUTI STARS  

SciTech Connect

We analyzed data accumulated during 2005 and 2006 by the Taiwan-American Occultation Survey (TAOS) in order to detect short-period variable stars (periods of {approx}<1 hr) such as {delta} Scuti. TAOS is designed for the detection of stellar occultation by small-size Kuiper Belt Objects and is operating four 50 cm telescopes at an effective cadence of 5 Hz. The four telescopes simultaneously monitor the same patch of the sky in order to reduce false positives. To detect short-period variables, we used the fast Fourier transform algorithm (FFT) in as much as the data points in TAOS light curves are evenly spaced. Using FFT, we found 41 short-period variables with amplitudes smaller than a few hundredths of a magnitude and periods of about an hour, which suggest that they are low-amplitude {delta} Scuti stars. The light curves of TAOS {delta} Scuti stars are accessible online at the Time Series Center Web site (http://timemachine.iic.harvard.edu)

Kim, D.-W.; Protopapas, P.; Alcock, C.; Wright, N. J.; Bianco, F. B.; Lehner, M. J. [Harvard Smithsonian Center for Astrophysics, Cambridge, MA 02138 (United States); Byun, Y.-I. [Department of Astronomy, Yonsei University, Seoul 120-749 (Korea, Republic of); Kyeong, J.; Lee, B.-C. [Korea Astronomy and Space Science Institute, Daejeon 305-348 (Korea, Republic of); Axelrod, T. [Steward Observatory, 933 North Cherry Avenue, Room N204 Tucson, AZ 85721 (United States); Chen, W.-P.; Lin, H.-C. [Institute of Astronomy, National Central University, No. 300, Jhongda Rd, Jhongli City, Taoyuan County 320, Taiwan (China); Coehlo, N. K.; Rice, J. A. [Department of Statistics, University of California Berkeley, 367 Evans Hall, Berkeley, CA 94720 (United States); Cook, K. H.; Marshall, S. L. [Institute for Geophysics and Planetary Physics, Lawrence Livermore National Laboratory, Livermore, CA 94550 (United States); Dave, R. [Initiative in Innovative Computing, School of Engineering and Applied Sciences, Harvard, Cambridge, MA 02138 (United States); King, S.-K.; Lee, T. [Institute of Astronomy and Astrophysics, Academia Sinica, P.O. Box 23-141, Taipei 106, Taiwan (China); Porrata, R. [Department of Astronomy, University of California Berkeley, 601 Campbell Hall, Berkeley, CA 94720 (United States)] (and others)

2010-02-15

280

Heterochromatin in the genus Artemia  

Microsoft Academic Search

A bisexual species of the genus Artemia (Crustacea, Phyllopoda), Artemia franciscana Barigozzi of San Francisco Bay and a parthenogenetic population of Artemia sp. of Tsing-Tao (China), both with 42 chromosomes, were compared with respect to the microscopic structure of the interphase larval nucleus, the microscopical structure of the prophase chromosomes and the DNA structure. — Artemia franciscana exhibits several chromocenters

C. Barigozzi; G. Badaracco; P. Plevani; L. Baratelli; S. Profeta; E. Ginelli; R. Meneveri

1984-01-01

281

Cultural Influences on Sexual Activity among Latina Adolescents  

Microsoft Academic Search

Early sexual activity among Latina adolescents has serious consequences (Chesson, Blandford, Gift, Tao, & Irwin, 2004; Mokdad, Marks, Stroup, & Gerberding, 2004; Schuster, 2003). Researchers have examined the influence of cultural variables such as assimilation, enculturation, gender roles, and ethnic identity on the sexual attitudes and behaviors of Latina adolescents (Benson & Torpy, 1995; Gómez & Marín, 1996; Jacobs, 2008;

Keyona M. Jarrett

2010-01-01

282

Observational Study of Long Waves in the Equatorial Pacific Ocean During the 1991-1993 El Nino.  

National Technical Information Service (NTIS)

Long waves in the equatorial Pacific Ocean during the 1991-1993 El Nino event were examined using temperature, current, and wind time series from the Tropical Oceans-Global Atmosphere Tropical Atmosphere-Ocean (TOGA-TAO) moored buoy array. Numerous episod...

T. W. Sitler

1994-01-01

283

Ground-based Measurements of Vertical Profiles and Columns of Atmospheric Trace Gases Over Toronto Using a New High-Resolution Fourier Transform Infrared Spectrometer  

NASA Astrophysics Data System (ADS)

The University of Toronto Atmospheric Observatory (TAO) has recently been established at Toronto, Canada. TAO includes several instruments, with a DA8 Fourier Transform Spectrometer (DA8 FTS, manufactured by ABB Bomem Inc., Québec, Canada) serving as the primary instrument at the facility. The geographic position of TAO (43.66°N, 79.40°W) makes it well suited for long-term measurements of mid-latitude stratospheric ozone and related species, while its urban setting enables measurements of tropospheric pollution. The DA8 FTS is based on a Michelson interferometer with a maximum optical path difference of 250 cm, providing a maximum unapodized resolution of 0.0026 cm-1. It is currently equipped with KBr and CaF2 beamsplitters, and InSb and HgCdTe detectors, for coverage of the spectral range from 700 to 4100 cm-1. A new heliostat (manufactured by Aim Controls Inc., California, USA) provides active solar tracking, collecting the incoming solar radiation and directing it into the FTS. The TAO DA8 FTS incorporates a new optical design recently developed by ABB Bomem Inc., which results in a fixed optical axis through the beamsplitter (and a fixed focal point on the detector) as well as a more stable modulation efficiency. The new instrument optics will be discussed. Next, the performance of the instrument will be examined in the context of standard NDSC (Network for the Detection of Stratospheric Change) trace gas column and vertical profile retrieval techniques, which use least squares fitting algorithms (SFIT, SFIT2). TAO has been operational (weather permitting) since October 2001. We have been retrieving columns and vertical profiles of HCl, HF, CH4, OCS, C2H6, CO, N2O and NO2 since May 2002. A detailed error analysis of retrieved columns and vertical profiles has been undertaken for the above species. Future plans for the TAO FTS include comparing our measurements with satellite measurements made by MOPITT, OSIRIS, and the upcoming ACE and MAESTRO instruments. Finally, we are investigating the feasibility of making broadband infrared measurements of aerosols using the TAO DA8 FTS.

Wiacek, A.; Yashcov, D.; Strong, K.; Boudreau, L.; Rochette, L.; Roy, C.

2002-12-01

284

[Principles of the medication for Graves' disease and countermeasures against adverse events induced by anti-thyroid drugs].  

PubMed

The Japan Thyroid Association published the guidelines for the treatment of Graves disease with antithyroid drugs(ATD) in 2006 and has updated it in 2011. The revised guidelines includes radioisotope therapy also. This article describes several topics about how to treat a patient with Graves' disease according to the guidelines 2011, focusing the difference between the guidelines 2006 and the guidelines 2011. PMID:23214061

Nakamura, Hirotoshi

2012-11-01

285

Successful treatment of exophthalmos and pretibial myxoedema with plasmapheresis.  

PubMed Central

A patient with Graves's disease with acute progressive exophthalmos and pretibial myxoedema was treated twice with plasmapheresis. Two weeks after the first treatment the symptoms recurred, but 20 weeks after the second treatment the exophthalmos was much improved and the pretibial myxoedema had disappeared. Analysis of sequential serum IgG concentrations and the thyroid-stimulating immunoglobulin index suggested that the two conditions were caused by specific IgGs. The results suggest that plasmapheresis has a useful place in the treatment of acute and rapidly progressive ophthalmopathy and pretibial myxoedema in patients with Graves's disease.

Dandona, P; Marshall, N J; Bidey, S P; Nathan, A; Havard, C W

1979-01-01

286

Toxic multinodular goiter with low radioactive iodine uptake.  

PubMed

A 74-year-old woman was referred to our hospital for goiter and persistent thyrotoxicosis. She had no signs of ophthalmopathy. She was not taking thyroid hormone. Thyroid CT revealed multiple nodules. The thyroid gland was not detected on (99m)Tc scintigraphy, (123)I uptake rate was 4.5% at 24 hours without hot nodules, and aberrant goiter was negative. After partial thyroidectomy, she was treated with levothyroxine. TRAb was undetectable during the disease course, and focal destructive change or chronic lymphocytic thyroiditis on the pathological specimens was not evident. We report a rare case of toxic multinodular goiter with low radioactive iodine uptake. PMID:21841330

Kahara, Toshio; Shimizu, Akiko; Uchiyama, Akio; Terahata, Shintaro; Tajiri, Junichi; Nishihara, Eijun; Miyauchi, Akira; Abo, Hitoshi; Sumiya, Hisashi; Ishikura, Kazuhide; Usuda, Rika; Noto, Hirofumi

2011-08-15

287

[Muscular diseases in hyperthyroidism].  

PubMed

Hyperthyroidism may present various muscular diseases, namely thyrotoxic chronic myopathy, myasthenia gravis, disthyroid ophthalmopathy and thyrotoxic periodic paralysis. Although infrequent, it is possible to find some of these clinical situations in a medical ward of a general hospital. Differential diagnosis must be made with chronic idiopathic polymyositis and certain congenital myopathies. We describe three patients with hyperthyroidism; one of these patients had chronic thyrotoxic myopathy and another had myasthenia gravis. The third had a thymolipoma and ocular changes probably corresponding to myasthenia gravis. PMID:7484269

Pissarra, F; Carvalho, M; Morais, C; Fortuna, J; Gonçalves, J G; João Neto, M

1995-09-01

288

Benchmark solutions for MHD solver development  

NASA Astrophysics Data System (ADS)

A benchmark solution is of great importance in validating algorithms and codes for magnetohydrodynamic (MHD) flows. Hunt and Shercliff's solutions are usually employed as benchmarks for MHD flows in a duct with insulated walls or with thin conductive walls, in which wall effects on MHD are represented by the wall conductance ratio. With wall thickness resolved, it is stressed that the solution of Sloan and Smith's and the solution of Butler's can be used to check the error of the thin wall approximation condition used for Hunt's solutions. It is noted that Tao and Ni's solutions can be used as a benchmark for MHD flows in a duct with wall symmetrical or unsymmetrical, thick or thin. When the walls are symmetrical, Tao and Ni's solutions are reduced to Sloan and Smith's solution and Butler's solution, respectively.

Tao, Zhen; Ni, MingJiu

2013-02-01

289

Berry Curvature and Phonon Hall Effect  

NASA Astrophysics Data System (ADS)

We establish the general phonon dynamics of magnetic solids by incorporating the Mead-Truhlar correction in the Born-Oppenheimer approximation. The effective magnetic-field acting on the phonons naturally emerges, giving rise to the phonon Hall effect. A general formula of the intrinsic phonon Hall conductivity is obtained by using the corrected Kubo formula with the energy magnetization contribution properly incorporated. The resulting phonon Hall conductivity is fully determined by the phonon Berry curvature and the dispersions. Based on the formula, the topological phonon system could be rigorously defined. In the low temperature regime, we predict that the phonon Hall conductivity is proportional to T^3 for the ordinary phonon systems, while that for the topological phonon systems has the linear T dependence with the quantized temperature coefficient. [4pt] [1] Tao Qin and Junren Shi, arXiv:1111.1322 (2011) [0pt] [2] Tao Qin, Qian Niu and Junren Shi, Phys. Rev. Lett., Accepted, (2011).

Qin, Tao; Shi, Junren

2012-02-01

290

Photocatalytic activity of R3MO7 and R2Ti2O7 (R=Y, Gd, La; M=Nb, Ta) for water splitting into H2 and O2.  

PubMed

The photocatalytic activities of R3MO7 and R2Ti2O7 (R=Y, Gd, La; M=Nb, Ta) strongly depended on the crystal structure. Overall, photocatalytic water splitting into H2 and O2 proceeded over La3TaO7 and La3NbO7, which have an orthorhombic weberite structure, Y2Ti2O7 and Gd2Ti2O7, which have a cubic pyrochlore structure, and La2Ti2O7, which has a monoclinic perovskite structure. All of these materials are composed of a network of corner-shared octahedral units of metal cations (TaO6, NbO6, or TiO6); materials without such a network were inactive. The octahedral network certainly increased the mobility of electrons and holes, thereby enhancing photocatalytic activity. PMID:16471807

Abe, Ryu; Higashi, Masanobu; Sayama, Kazuhiro; Abe, Yoshimoto; Sugihara, Hideki

2006-02-01

291

Structural defects working as active oxygen-reduction sites in partially oxidized Ta-carbonitride core-shell particles probed by using surface-sensitive conversion-electron-yield x-ray absorption spectroscopy  

NASA Astrophysics Data System (ADS)

We analyzed the local structure of the surface Ta-oxide phase of TaCN/Ta2O5 core-shell particles that have a high oxygen reduction activity by using surface-sensitive conversion-electron-yield x-ray absorption spectroscopy, suppressing the contribution from the TaCN cores. The radial structure analysis revealed that the catalytically-active Ta2O5 phase in the TaCN/Ta2O5 particle surface contains oxygen-vacancy defects with shorter Ta-O bonds leading to the slight expansion of the first Ta-O shell. Such oxygen defects are likely responsible for the oxygen reduction capability by creating electronically favorable oxygen adsorption sites and electron conduction pathways.

Imai, Hideto; Matsumoto, Masashi; Miyazaki, Takashi; Fujieda, Shinji; Ishihara, Akimitsu; Tamura, Motoko; Ota, Ken-Ichiro

2010-05-01

292

CORBA Evaluations for the BABAR Online System  

SciTech Connect

The Common Object Request Broker Architecture (CORBA) is a software system to deal with distributed object computing. The release of CORBA version 2, and real implementations from numerous vendors (both freeware and payware) have made its use very attractive for interprocess and interprocessor communication within an object-oriented software system. A number of object request brokers (ORBs) were evaluated for possible use within the BABAR Online system. Given an expectation for a reasonable level of performance within the Online system, it was essential to characterize the behavior and test the response of these products prior to their adoption. This paper summarizes the results of a systematic performance study of six ORB products. The products tested include: Visibroker, Orbix, DAIS, Omnibroker, OmniORB2, and TAO. Performance results of ORB products, including a test of TCP/IP sockets, are compared. These tests resulted in the adoption of the TAO ORB for use within the BABAR Online system.

Glanzman, Thomas

1998-11-03

293

The impacts of ozonation on oil sands process-affected water biodegradability and biofilm formation characteristics in bioreactors.  

PubMed

To examine the effects of the ozonation process (as an oxidation treatment for water and wastewater treatment applications) on microbial biofilm formation and biodegradability of organic compounds present in oil sands process-affected water (OSPW), biofilm reactors were operated continuously for 6weeks. Two types of biofilm substrate materials: polyethylene (PE) and polyvinylchloride (PVC), and two types of OSPW-fresh and ozonated OSPWs-were tested. Endogenous microorganisms, in OSPW, quickly formed biofilms in the reactors. Without ozonation, the bioreactor (using endogenous microorganisms) removed 13.8% of the total acid-extractable organics (TAO) and 18.5% of the parent naphthenic acids (NAs) from fresh OSPW. The combined ozonation and biodegradation process removed 87.2% of the OSPW TAO and over 99% of the OSPW parent NAs. Further UPLC/HRMS analysis showed that NA biodegradability decreased as the NA cyclization number increased. Microbial biofilm formation was found to depend on the biofilm substrate type. PMID:23313671

Hwang, Geelsu; Dong, Tao; Islam, Md Sahinoor; Sheng, Zhiya; Pérez-Estrada, Leónidas A; Liu, Yang; Gamal El-Din, Mohamed

2012-12-12

294

Impact of tellurite-based glass structure on Raman gain  

NASA Astrophysics Data System (ADS)

Raman gain efficiency and structure of tellurite glasses in the TeO2-TaO5/2-ZnO system have been investigated by Raman and IR spectroscopies. It has been found that replacement of TaO5/2 by ZnO does not significantly modify the respective proportion of TeO4, TeO3 and TeO3+1 entities but induces an important decrease of the TeO4 structural units Raman cross section. Change of the glass structure at the middle range length scale is proposed to be at the origin of the large decrease of the Raman cross section of the TeO4 units.

Guery, Guillaume; Fargues, Alexandre; Cardinal, Thierry; Dussauze, Marc; Adamietz, Frederic; Rodriguez, Vincent; Musgraves, John David; Richardson, Kathleen; Thomas, Philippe

2012-12-01

295

Pacific Marine Environmental Laboratory On-Line Data  

NSDL National Science Digital Library

This site provides access to a variety of oceanographic and atmospheric data products. Some of the products available include Ocean Buoy data, tsunami data, 1997-98 El Nino sea level for the US West Coast, Alaska, and Hawaii, real-time images and data from research ships, climate databases via the FERRET program, the Atmospheric Chemistry Data Server, seafloor data from the coaxial segment of the Juan de Fuca Ridge, data on exploration of hydrothermal vents, Florida current transport data, EPIC observational data, Pacific Ocean hydrography from WOCE P15S Cruise cross sections, Ka'imimoana Shipboard Acoustic Doppler Current Profile (ADCP) Data, Atmospheric Chemistry Trace Gas Program data, Historical TAO CTD data, near real-time TAO CTD data, and access to other distributed NOAA data and information. This site also has animations and virtual reality displays of tsunamis, El Nino and La Nina, fisheries oceanography, and Convection and Circulation at Ocean Ridge Crests.

296

Real-time detection and characterization of individual flowing airborne biological particles: fluorescence spectra and elastic scattering measurements  

NASA Astrophysics Data System (ADS)

Real-time methods which is reagentless and could detect and partially characterize bioaerosols are of current interest. We present a technique for real-time measurement of UV-excited fluorescence spectra and two-dimensional angular optical scattering (TAOS) from individual flowing biological aerosol particles. The fluorescence spectra have been observed from more than 20 samples including Bacillus subtilis, Escherichia coli, Erwinia herbicola, allergens, dust, and smoke. The S/N and resolution of the spectra are sufficient for observing small lineshape differences among the same type of bioaerosol prepared under different conditions. The additional information from TAOS regarding particle size, shape, and granularity has the potential of aiding in distinguishing bacterial aerosols from other aerosols, such as diesel and cigarette smoke.

Pan, Yong-Le; Holler, Stephen; Chang, Richard K.; Hill, Steven C.; Pinnick, Ronald G.; Niles, Stanley; Bottiger, Jerold R.; Bronk, Burt V.

1999-11-01

297

Breakup of the H2 molecule by xuv laser pulses: A time-dependent treatment in prolate spheroidal coordinates  

NASA Astrophysics Data System (ADS)

We present theoretical predictions for one-photon double-ionization of H2 by an xuv laser pulse. The results were obtained by solving the time-dependent Schrödinger equation in prolate spheroidal coordinates. Good agreement is obtained with predictions from other time-dependent and time-independent calculations, except for the recent "exterior complex scaling" treatment by Tao et al. (Phys. Rev. A 82 023423).

Guan, Xiaoxu; Bartschat, Klaus; Schneider, Barry I.

2012-11-01

298

Ta2O5-gates of pH-sensitive devices: Comparative spectroscopic and electrical studies  

Microsoft Academic Search

Thin films of tantalum pentoxide (Ta,O,) were prepared on Si\\/SiOz substrates by thermal oxidation of tantalum. In systematic oxidation studies we followed the growth of the Ta205\\/Si02 interface. The oxide layers and their interfaces were characterized by SIMS, SAM, XPS, by comparative C-V measurements and by pH-(ISFET) sensitivities. Depending on the oxidation procedure, we find non-ideal stoichiom- etries of the

P. GIMMEL; B. GOMPF; D. SCHMEISSER; H. D. WIEMHOFER; W. GdPEL

1989-01-01

299

Comparison of TRMM Precipitation Retrievals with Rain Gauge Data from Ocean Buoys  

Microsoft Academic Search

Four years of precipitation retrievals from the Tropical Rainfall Measuring Mission (TRMM) satellite are compared with data from 25 surface rain gauges on the National Oceanic and Atmospheric Administration\\/ Pacific Marine Environment Laboratory (NOAA\\/PMEL) Tropical Atmosphere-Ocean Array\\/Triangle Trans-Ocean Buoy Network TAO\\/TRITON buoy array in the tropical Pacific. The buoy gauges have a significant advantage over island-based gauges for this purpose

Kenneth P. Bowman

2005-01-01

300

Adequate sleep among adolescents is positively associated with health status and health-related behaviors  

Microsoft Academic Search

BACKGROUND: Amount of sleep is an important indicator of health and well-being in children and adolescents. Adequate sleep (AS: adequate sleep is defined as 6–8 hours per night regularly) is a critical factor in adolescent health and health-related behaviors. The present study was based on a health promotion project previously conducted on adolescents in Tao-Yuan County, Taiwan. The aim was

Mei-Yen Chen; Edward K Wang; Yi-Jong Jeng

2006-01-01

301

Numerical study of local heat transfer coefficient and fin efficiency of wavy fin-and-tube heat exchangers ? ? The present work is supported by the National Science Fund for Distinguished Young Scholars from the National Natural Science Foundation of China (No. 50425620), and the Key Grant Project of Chinese Ministry of Education (No. 306014)  

Microsoft Academic Search

Three-dimensional numerical simulations were performed for laminar flow of wavy fin-and-tube heat exchangers by using body-fitted coordinates (BFC) method with fin efficiency effect accounted. The prediction results of average Nusselt number, friction factor and fin efficiency were compared with the related experimental correlations [R.C. Xin, H.Z. Li, H.J. Kang, W. Li, W.Q. Tao, An experimental investigation on heat transfer and

Y. B. Tao; Y. L. He; J. Huang; Z. G. Wu; W. Q. Tao

2007-01-01

302

How life is associated with colors in Chinese culture: utilizing colors based on Chinese five-essence theory  

Microsoft Academic Search

Chinese believe that Feng-shui, Ch'i, Tao, Yin and Yang are major components rooted in Chinese culture. Many people know life has to balance and harmonize with nature and the universe through the Five-essence. Ancient wisdom is successfully interwoven with mankind and the natural world. Elements such as orientation, season, color, sound, facial organs, viscera, stars, and numbers can be associated

Tien-Rein Lee

2002-01-01

303

SAGD as Follow-Up to Cyclic Steam Stimulation in a Medium Deep and Extraheavy-Oil  

Microsoft Academic Search

Guan-tao oil layer of Shu 1 Block in Liaohe oilfield is a medium deep and extra heavy oil reservoir, which has high porosity and high perm with edge water. In 2001, cyclic steam stimulation was applied with square well pattern and well- space 70m. After 9-10 cycles the stimulation development effect deteriorated and the degree of reserve recovery was only

Zhou Da-sheng

304

Side bands of the vibrational spectrum of interstitial elements in a metal lattice  

Microsoft Academic Search

The dynamics of oxygen atoms in Ta-O solid solution has been studied by the slow-neutron inelastic scattering method. Indications\\u000a have been obtained for the existence of vibration-rotation excitations of an interstitial atom in a metal lattice. In addition\\u000a to the peaks corresponding to the fundamental oscillations of a harmonic oscillator (??1,2 ? 42 meV and ??3 ? 82 meV), side

S. I. Morozov; V. V. Kazarnikov; A. S. Ivanov

2006-01-01

305

Comparative Study of Electrocoagulation and Electrooxidation Processes for the Degradation of Ellagic Acid From Aqueous Solution  

Microsoft Academic Search

A comparative study of electrocoagulation and electrooxidation processes for the degradation of ellagic acid from aqueous solution was carried out. For the electrocoagulation process, metallic iron was used as electrodes whereas graphite and RuO2\\/IrO2\\/TaO2 coated titanium electrodes were used for the electrooxidation processes. The effect of the process variables such as initial pH, concentration of the supporting electrolyte, applied current

M. Muthukumar; M. Govindaraj; A. Muthusamy; G. Bhaskar Raju

2010-01-01

306

Electrochemical removal of CI Acid orange 10 from aqueous solutions  

Microsoft Academic Search

The removal of CI Acid orange 10 from aqueous solutions was studied by electrocoagulation and electrooxidation techniques. For electrocoagulation, metallic iron was used as electrodes whereas graphite and IrO2\\/TaO2\\/RuO2 coated titanium were used in the case of electrooxidation. During electro-coagulation, the CI Acid orange 10 molecule was split into aniline and 1-amino-2-naphthol-6,8-disulfonic acid due to reductive cleavage of azo bond.

M. Muthukumar; M. Thalamadai Karuppiah; G. Bhaskar Raju

2007-01-01

307

Anatomy of a nanoscale conduction channel reveals the mechanism of a high-performance memristor.  

PubMed

By employing a precise method for locating and directly imaging the active switching region in a resistive random access memory (RRAM) device, a nanoscale conducting channel consisting of an amorphous Ta(O) solid solution surrounded by nearly stoichiometric Ta(2) O(5) is observed. Structural and chemical analysis of the channel combined with temperature-dependent transport measurements indicate a unique resistance switching mechanism. PMID:22065427

Miao, Feng; Strachan, John Paul; Yang, J Joshua; Zhang, Min-Xian; Goldfarb, Ilan; Torrezan, Antonio C; Eschbach, Peter; Kelley, Ronald D; Medeiros-Ribeiro, Gilberto; Williams, R Stanley

2011-11-08

308

Geologic map of the Latir Volcanic Field, and adjacent areas, northern New Mexico  

USGS Publications Warehouse

Development of the Rio Grande Rift beginning at about 15 Ma was accompanied by development of the north-south trending normal faults along the western foot of the Taos Range. The rift is filled with thousands of meters of clastic sediments interleaved with basalt flows, some as young as 3.6 Ma. The bounding faults of the rift cut the Questa Caldera so that the western part of the original structure is now deeply buried beneath the rift fill.

Lipman, P. W.; Reed, J. C., Jr.

1989-01-01

309

THE GLOBAL TROPICAL MOORED BUOY ARRAY  

Microsoft Academic Search

This paper describes the Global Tropical Moored Buoy Array (GTMBA), which is a multi-national effort to provide data in real time for climate research and forecasting. Components of the global array include the Tropical Atmosphere Ocean\\/Triangle Trans-Ocean Buoy Network (TAO\\/TRITON) in the Pacific, the Prediction and Research Moored Array in the Tropical Atlantic (PIRATA), and the Research Moored Array for

M. Ravichandran; J. Vialard; D. Vousden

310

The Taoism Information Page  

NSDL National Science Digital Library

Affiliated with the WWW Virtual Library for Asian Studies, this virtual library, provided by Gene R. Thursby, Professor in the Department of Religion at the University of Florida, offers a large number of Taoism resources. Users will find links to general introductions to Taoism, translations and other information for the Tao Te Ching, the Chuang-tzu, and the I Ching. Other resources include links to information on Feng Shui, Confucianism and Buddhism, Taoism and Chinese Culture, and Taoism and Martial Arts.

311

Paleomagnetism and Potassium-Argon Ages of Some Volcanic Rocks from the Rio Grande Gorge, New Mexico  

Microsoft Academic Search

Successive lava flows exposed in the Rio Grande gorge, near Taos, New Mexico, can be divided into three groups, each of different magnetic polarity.: the upper and lower groups have a normal polarity, whereas the middle one has a reversed polarity. K-Ar radiometric ages indicate that the base of the upper normal polarity sequence is about 3.7 m.y. old and

M. Ozima; M. Kono; I. Kaneoka; H. Kinoshita; Kazuo Kobayashi; T. Nagata; E. E. Larson; D. Strangway

1967-01-01

312

Regional discrimination studies: Phase III. Scientific report No. 3  

SciTech Connect

This report consists of three parts. Part 1, `Construction of Regional Ground Truth Data Bases Using Seismic And Infrasound Data` is by Gordon Sorrells, Eugene Herrin, and Jessie Bonner with contributions from Jack Swanson, Sarah Deering and Angela Maddox. Part 2, `Seismic And Infrasound Data Observations At TXAR` is by Jessie Bonner, Sarah Deering, Tao Liu, Jack Swanson and Ileana Tibuleac. Part 3, consists of the Acknowledgments called for by the contract.

Bonner, J.; Herrin, E.; Sorrells, G.G.

1997-03-01

313

Evaluation of wind vectors observed by QuikSCAT\\/SeaWinds using ocean buoy data  

Microsoft Academic Search

Wind vectors observed by QuikSCAT\\/SeaWinds are compared with wind and wave data from offshore moored buoys. Effects of oceanographic and atmospheric parameters on the scatterometry are also assessed by using the buoy data. The QuikSCAT\\/SeaWinds Standard Wind Data Products (Level 2B) were collocated with the Japan Meteorological Agency (JMA), National Data Buoy Center (NDBC), and Tropical Atmosphere Ocean (TAO) buoys.

Naoto Ebuchi

2001-01-01

314

GLASSROOTS: DESIGN AND EVALUATION FRAMEWORK FOR AN INNER CITY GLASSBLOWING PROGRAM FOR AT-RISK YOUTH  

Microsoft Academic Search

GlassRoots is a multivalent program, designed to address the critical developmental issues facing a segment of the at-risk youth population in the inner city, through the medium of glass blowing. Based on previous work in Tacoma WA and Taos NM, it is an extensive adaptation and extension of existing models. Two of the extensions involve basic, advanced and computer-aided design

Thomas A. Bryant; Patricia F. Kettenring; Pamela Shipley

315

The Crystal Project : A Study of Inquiry-based Science and Technology Learning in Manufacturing Settings  

Microsoft Academic Search

This study examines the educational implications of inquiry-based science learning from a STS (science, technology and society) and process \\/product-oriented approach. Inquiry-based teaching is most often used in outdoo r natural science classes; however, the research team selected two manufacturing plants (Nan-Chiao Soap Factory in Tao-Yuan County and a bread factory in Chung-Li City, Taiwan) as the learning settings for

Jon-Chao Hong; Jeen-Yueh Kao

316

In-vitro and in-vivo evaluation of the drug-drug interaction between fluvoxamine and clozapine  

Microsoft Academic Search

The drug-drug interaction between fluvoxamine (FLV) and clozapine (CLZ) was evaluated by in-vitro and in-vivo methods. In-vitro\\u000a studies were conducted using human hepatic microsomal preparations with standard chemical inhibitors of the cytochrome P450\\u000a (CYP 450) isozyme system. Furafyline, FLV, troleandomycin (TAO) and erythromycin were used as the chemical inhibitors. For\\u000a the in-vivo study, nine male schizophrenic patients were administered a

W.-H. Chang; Bruce Augustin; Troy ZumBrunnen; Hui-Ching Liu; Yusuf Kazmi; Michael W. Jann

1999-01-01

317

Acupuncture plus oral herbal decoction and low back pain: A report of 162 cases  

Microsoft Academic Search

One hundred and sixty-two low back pain cases due to intervertebral disc problem were treated by puncturing 30 mm in depth\\u000a with even reinforcing and reducing manipulation on Jiaji points (Ex-B 2) in the lumbar area plus patterned oral herbal decoction,\\u000a Tao Hong Siwu Decoction. The result showed that 65 cases got marked effect, 53 cases got good effect, 37

Meng Xian-pu; An Jin-ge; Shao Xiu-fen

2005-01-01

318

Aerobic fate and impact of canola oil in aquatic media  

Microsoft Academic Search

The fate of canola oil in water under aerobic conditions was studied in respirometry tests. First-order biodegradation rates\\u000a were estimated for a refined oil (commercial canola oil, CCO), 0.0037 h?1, and for two synthetic oils, one prepared with mono-acid triacylglycerols (TAO) 0.0048 h?1, and the other with free fatty acids and glycerol (FAO) 0.0038 h?1. Two abiotic factors limited substrate bioavailability: the autoxidation

Pablo Campo; Yuechen Zhao; Makram T. Suidan; Albert D. Venosa

319

Observed and CAM3 GCM Sea Surface Wind Speed Distributions: Characterization, Comparison, and Bias Reduction  

Microsoft Academic Search

Climatological surface wind speed probability density functions (PDFs) estimated from observations are characterized and used to evaluate, for the first time, contemporaneous wind PDFs predicted by a GCM. The observations include NASA's global Quick Scatterometer (QuikSCAT) dataset, the NCEP\\/ Department of Energy Global Reanalysis 2 (NCEP-2) 6-hourly reanalysis, and the Tropical Atmosphere Ocean (TAO)\\/Triangle Trans-Ocean Buoy Network (TRITON) moored buoy

Scott B. Capps; Charles S. Zender

2008-01-01

320

Raman investigation on (Ta 2O 5) 1?x(TiO 2) x system at different temperatures and pressures  

Microsoft Academic Search

Micro Raman spectra for (Ta2O5)1?x(TiO2)x reveal an induced Raman enhancement of the low frequency phonon modes for a critical TiO2 content, x = 0.08. The temperature and pressure effects on these modes have also been studied. The Raman enhancement is shown to be associated with effects of the superstructure which is composed of TiO6 octahedra and Ta-O clusters. Pressure Raman

J. F. Meng; Brajesh K. Rai; R. S. Katiyar; A. S. Bhalla

1997-01-01

321

Mountain fronts, base-level fall, and landscape evolution: Insights from the southern Rocky Mountains  

Microsoft Academic Search

Mountain ranges in the southern Rocky Mountains, fi rst uplifted during the ear- ly Cenozoic Laramide orogeny, have followed separate landscape evolutionary path- ways in the late Cenozoic. We present a model that reconstructs the post-Laramide tectonic and geomorphic history of Sierra Nacimiento and the Taos Range, two nearly adjacent rift-fl ank ranges in north-central New Mexico that serve to

Kurt L. Frankel; Frank J. Pazzaglia

2006-01-01

322

Observations of Cloud, Radiation, and Surface Forcing in the Equatorial Eastern Pacific  

Microsoft Academic Search

In this paper the authors report on a study of cloud and surface flux processes in the tropical eastern Pacific Ocean based on a series of ship-based cloud and flux measurements made during fall (1999-2002) and spring (2000-02) maintenance cruises along the 95° and 110°W Tropical Atmosphere Ocean (TAO) buoy lines between 8°S and 12°N. The year-to-year and seasonal variabilities

C. W. Fairall; Taneil Uttal; Duane Hazen; Jeffrey Hare; Meghan F. Cronin; Nicholas Bond; Dana E. Veron

2008-01-01

323

The equatorial undercurrent, meridional overturning circulation, and their roles in mass and heat exchanges during El Niño events in the tropical Pacific ocean  

Microsoft Academic Search

The equatorial undercurrent (EUC), the shallow meridional overturning cells feeding it, and their role in El Niño and decadal\\u000a variability in the equatorial Pacific are studied using both in situ data and an ocean general circulation model. Using temperature\\u000a and current data from the TAO\\/TRITON moorings at the equator, their data gaps are filled and it was shown that continuous

Takeshi Izumo

2005-01-01

324

Pausing Mechanism of Transition from La Nina to El Nino: a View from Observational Heat Balance in the Mixed Layer from 1999 to 2002  

Microsoft Academic Search

Heat balance in the surface mixed layer is examined at the eastern equatorial Pacific Ocean (0¢ª 140¢ªW) from 1999 La Nina to 2002 El Nino. Observational data from TAO\\/TRITON moored buoy are used for analysis of heat balance. The result shows that the interannual variation of eddy heat flux due to the tropical instability waves slows down the transition from

M. Nagura; K. Ando; K. Mizuno

2006-01-01

325

Heat capacity, enthalpy and entropy of ternary bismuth tantalum oxides  

NASA Astrophysics Data System (ADS)

Heat capacity and enthalpy increments of ternary bismuth tantalum oxides Bi4Ta2O11, Bi7Ta3O18 and Bi3TaO7 were measured by the relaxation time method (2-280 K), DSC (265-353 K) and drop calorimetry (622-1322 K). Temperature dependencies of the molar heat capacity in the form Cpm=445.8+0.005451T-7.489×106/T2 J K-1 mol-1, Cpm=699.0+0.05276T-9.956×106/T2 J K-1 mol-1 and Cpm=251.6+0.06705T-3.237×106/T2 J K-1 mol-1 for Bi3TaO7, Bi4Ta2O11 and for Bi7Ta3O18, respectively, were derived by the least-squares method from the experimental data. The molar entropies at 298.15 K, S°m(298.15 K)=449.6±2.3 J K-1 mol-1 for Bi4Ta2O11, S°m(298.15 K)=743.0±3.8 J K-1 mol-1 for Bi7Ta3O18 and S°m(298.15 K)=304.3±1.6 J K-1 mol-1 for Bi3TaO7, were evaluated from the low-temperature heat capacity measurements.

Leitner, J.; Jakeš, V.; Sofer, Z.; Sedmidubský, D.; R?ži?ka, K.; Svoboda, P.

2011-02-01

326

Petroleum coke adsorption as a water management option for oil sands process-affected water.  

PubMed

Water is integral to both operational and environmental aspects of the oil sands industry. A water treatment option based on the use of petroleum coke (PC), a by-product of bitumen upgrading, was examined as an opportunity to reduce site oil sands process-affected water (OSPW) inventories and net raw water demand. Changes in OSPW quality when treated with PC included increments in pH levels and concentrations of vanadium, molybdenum, and sulphate. Constituents that decreased in concentration after PC adsorption included total acid-extractable organics (TAO), bicarbonate, calcium, barium, magnesium, and strontium. Changes in naphthenic acids (NAs) speciation were observed after PC adsorption. A battery of bioassays was used to measure the OSPW toxicity. The results indicated that untreated OSPW was toxic towards Vibrio fischeri and rainbow trout. However, OSPW treated with PC at appropriate dosages was not acutely toxic towards these test organisms. Removal of TAO was found to be an adsorption process, fitting the Langmuir and Langmuir-Freundlich isotherm models. For TAO concentrations of 60 mg/L, adsorption capacities ranged between 0.1 and 0.46 mg/g. This study demonstrates that freshly produced PC from fluid cokers provides an effective treatment of OSPW in terms of key constituents' removal and toxicity reduction. PMID:22575375

Zubot, Warren; MacKinnon, Michael D; Chelme-Ayala, Pamela; Smith, Daniel W; Gamal El-Din, Mohamed

2012-05-09

327

{Ta12}/{Ta16} cluster-containing polytantalotungstates with remarkable photocatalytic H2 evolution activity.  

PubMed

Four novel polytantalotungstates K(5)Na(4)[P(2)W(15)O(59)(TaO(2))(3)]·17H(2)O (1), K(8)Na(8)H(4)[P(8)W(60)Ta(12)(H(2)O)(4)(OH)(8)O(236)]·42H(2)O (2), Cs(3)K(3.5)H(0.5)[SiW(9)(TaO(2))(3)O(37)]·9H(2)O (3), and Cs(10.5)K(4)H(5.5)[Ta(4)O(6)(SiW(9)Ta(3)O(40))(4)]·30H(2)O (4) were synthesized. Compounds 1 and 3 are tris-(peroxotantalum)-substituted Dawson- and Keggin-type derivatives, whereas 2 and 4 are tetrameric oligomers containing respectively an unprecedented {Ta(12)} and {Ta(16)} cluster core. The photocatalytic activities of 2 and 4 for H(2) evolution from water were evaluated. The significantly enhanced performance against the control K(6)[P(2)W(18)O(62)] can be attributed to the modulation of the electronic structures of these novel POMs by Ta incorporation. The highest activity observed so far with the use of 2 can be further rationalized by the presence of distorted heptacoordinate Ta atoms in the form of TaO(7) pentagonal bipyramid. PMID:23130823

Li, Shujun; Liu, Shumei; Liu, Shuxia; Liu, Yiwei; Tang, Qun; Shi, Zhan; Ouyang, Shuxin; Ye, Jinhua

2012-11-20

328

Thromboangiitis Obliterans (Buerger's Disease)--Current Practices  

PubMed Central

Thromboangiitis obliterans (TAO) is a nonatherosclerotic, segmental inflammatory disease that most commonly affects the small and medium-sized arteries and veins in the upper and lower extremities. Cigarette smoking has been implicated as the main etiology of the disease. In eastern parts of the world TAO forms 40–60% of peripheral vascular diseases. Clinical features and angiographic finding are the basis of early diagnosis of TAO. Abstinence from smoking is the only definitive treatment to prevent disease progression. Medical management in form of aspirin, pentoxyfylline, cilostazol, and verapamil increase pain-free walking distance in intermittent claudication, but long term usage fails to prevent disease progression in patients who continue to smoke. Surgical treatment in form of revascularization, lumbar sympathectomy, omentopexy, and Ilizarov techniques help reduce pain and promote healing of trophic changes. Newer treatment modalities like spinal cord stimulation, prostacyclin, bosentan, VEGF, and stem cell therapy have shown promising results. Latest treatment options include peripheral mononuclear stem cell, and adipose tissue derived mononuclear stem cells have been shown to be effective in preventing disease progression, decrease major amputation rates, and improving quality of life.

Tiwari, Rahul; Kumar Prabhuswamy, Vinod

2013-01-01

329

The differential diagnosis and classification of eyelid retraction.  

PubMed Central

PURPOSE: Classification schemes are useful in the formulation of differential diagnoses. Thoughtful commentary has been devoted to the classification of blepharoptosis, but the causes of eyelid retraction have received less attention in published reports. Although eyelid retraction most frequently is associated with Graves' ophthalmopathy, numerous other entities may cause the sign. This study was undertaken to provide a more comprehensive differential diagnosis and classification of eyelid retraction. METHODS: A series of patients with eyelid retraction was studied, and pertinent published reports were reviewed. RESULTS: Forty-four patients with different causes for eyelid retraction are described. Normal thyroid function and regulation were confirmed in all patients in whom Graves' ophthalmopathy could not be excluded by clinical, biochemical, or historical criteria. CONCLUSION: Based on a series of patients and reported cases, a differential diagnosis for eyelid retraction is proposed using a classification system comprising three categories (neurogenic, myogenic, and mechanistic). Images FIGURE 1 FIGURE 2 FIGURE 3 A FIGURE 3 B FIGURE 4 FIGURE 5 FIGURE 6 FIGURE 7 A FIGURE 7 B FIGURE 7 C FIGURE 7 D FIGURE 7 E FIGURE 8 FIGURE 9 FIGURE 10 A FIGURE 10 B FIGURE 10 C FIGURE 11 A FIGURE 11 B

Bartley, G B

1995-01-01

330

The Role of Oxidative Stress on the Pathogenesis of Graves' Disease  

PubMed Central

Graves' disease is a most common cause of hyperthyroidism. It is an autoimmune disease, and autoimmune process induces an inflammatory reaction, and reactive oxygen species (ROSs) are among its products. When balance between oxidants and antioxidants is disturbed, in favour of the oxidants it is termed “oxidative stress” (OS). Increased OS characterizes Graves' disease. It seems that the level of OS is increased in subjects with Graves' ophthalmopathy compared to the other subjects with Graves' disease. Among the other factors, OS is involved in proliferation of orbital fibroblasts. Polymorphism of the 8-oxoG DNA N-glycosylase 1 (hOGG1) involved in repair of the oxidative damaged DNA increases in the risk for developing Grave's disease. Treatment with glucocorticoids reduces levels of OS markers. A recent large clinical trial evaluated effect of selenium on mild Graves' ophthalmopathy. Selenium treatment was associated with an improved quality of life and less eye involvement and slowed the progression of Graves' orbitopathy, compared to placebo.

Zarkovic, Milos

2012-01-01

331

Downregulation of Mitochondrial Porin Inhibits Cell Growth and Alters Respiratory Phenotype in Trypanosoma brucei? †  

PubMed Central

Porin is the most abundant outer membrane (OM) protein of mitochondria. It forms the aqueous channel on the mitochondrial OM and mediates major metabolite flux between mitochondria and cytosol. Mitochondrial porin in Trypanosoma brucei, a unicellular parasitic protozoan and the causative agent of African trypanosomiasis, possesses a ?-barrel structure similar to the bacterial OM porin OmpA. T. brucei porin (TbPorin) is present as a monomer as well as an oligomer on the mitochondrial OM, and its expression is developmentally regulated. In spite of its distinct structure, the TbPorin function is similar to those of other eukaryotic porins. TbPorin RNA interference (RNAi) reduced cell growth in both procyclic and bloodstream forms. The depletion of TbPorin decreased ATP production by inhibiting metabolite flux through the OM. Additionally, the level of trypanosome alternative oxidase (TAO) decreased, whereas the levels of cytochrome-dependent respiratory complexes III and IV increased in TbPorin-depleted mitochondria. Furthermore, the depletion of TbPorin reduced cellular respiration via TAO, which is not coupled with oxidative phosphorylation, but increased the capacity for cyanide-sensitive respiration. Together, these data reveal that TbPorin knockdown reduced the mitochondrial ATP level, which in turn increased the capacity of the cytochrome-dependent respiratory pathway (CP), in an attempt to compensate for the mitochondrial energy crisis. However, a simultaneous decrease in the substrate-level phosphorylation due to TbPorin RNAi caused growth inhibition in the procyclic form. We also found that the expressions of TAO and CP proteins are coordinately regulated in T. brucei according to mitochondrial energy demand.

Singha, Ujjal K.; Sharma, Shvetank; Chaudhuri, Minu

2009-01-01

332

Enhancement of tropical ocean evaporation and sensible heat flux by atmospheric mesoscale systems  

SciTech Connect

The enhancement of monthly averaged evaporation by atmospheric mesoscale systems is estimated form long-term hourly observations of surface meteorological data from the Tropical Ocean Global Atmosphere (TOGA) Tropical Atmosphere Ocean (TAO) buoy moorings over the equatorial Pacific Ocean and a bulk aerodynamic flux algorithm developed as a result of the TOGA Coupled Ocean-Atmosphere Response Experiment (COARE). It is shown that mesoscale enhancement is due primarily to the lack of wind steadiness on subsynoptic timescales and is associated with periods of significant precipitation. The magnitude of the mesoscale enhancement of monthly averaged sea surface evaporation is found to be {approximately}10% or less of the total. During occasional periods with weak and variable winds over the western Pacific warm pool and the other major precipitation zones in the equatorial Pacific, the mesoscale enhancement of monthly averaged evaporation can reach 30% of the total evaporation. A similar result is obtained for mesoscale enhancement of diffusive air-sea sensible heat transfer using data form TOGA TAO moorings. However, a comparison of results from the colocated TAO and Improved METeorological measurements (IMET) moorings during TOGA COARE, and results previously reported form a pre-COARE cruise in the western Pacific warm pool region, indicate that processes in addition to mesoscale wind variability may be important contributors to the mesoscale enhancement of the sensible heat flux. It is suggested that the most important effects of atmospheric mesoscale systems on tropical ocean evaporation and sensible heat flux are represented in existing climatologies. 34 refs., 9 figs., 4 tabs.

Esbensen, S.K. [Oregon State Univ., Corvallis (United States); McPhaden, M.J. [NOAA/Pacific Marine Environmental Lab., Seattle, WA (United States)

1996-10-01

333

The I Ching and the psyche-body connection.  

PubMed

Carl G. Jung's fateful meeting with Richard Wilhelm in 1929 has helped to build a bridge of depth psychological understanding between the East and the West. When Jung emerged from his 'confrontation with the unconscious', he felt validated by Wilhelm in his discovery of the healing power of medieval alchemical symbolism for the European psyche. Analytical psychology however offers a scientific, psychological understanding of Chinese wisdom as contained in the I Ching and Taoist alchemy. The Taoist alchemical tradition (also known as the Inner Elixir tradition of which 'The Secret of the Golden Flower' is a sample text) is based on the premise that psychological experience of the Tao can be achieved through mental and physiological means such as breathing and meditative techniques, gymnastics, dietary regimens such as fasting, consumption of medicinal herbs and minerals, and special sexual practices. This tradition incorporates the I Ching and traditional Chinese medicine in the alchemical opus. Taoist alchemy assumes the primacy of the physical body in the process of self-realization. The psychological and cosmic forces of the trigrams of the I Ching are stored in the internal organs of the body and are the basic material for the experience of Tao. The internal organs are the foundation of the material and subtle bodies and through cultivation, the body becomes spiritualized as the spirits are embodied. The body as a reflection of the entire cosmos becomes the residence of the gods. The realization of a new consciousness is symbolized by the hexagram Fu, meaning rebirth. The Chinese notion of Tao coincides with Jung's postulation of the unus mundus, the unity of existence which underlies the duality of psyche and matter, the psycho-physical background of existence. In this light, in the world of inner experience, East and West follow similar paths symbolically. PMID:15817045

Ma, Shirley S Y

2005-04-01

334

First-principles density functional calculation of electrochemical stability of fast Li ion conducting garnet-type oxides.  

PubMed

The research and development of rechargeable all-ceramic lithium batteries are vital to realize their considerable advantages over existing commercial lithium ion batteries in terms of size, energy density, and safety. A key part of such effort is the development of solid-state electrolyte materials with high Li(+) conductivity and good electrochemical stability; lithium-containing oxides with a garnet-type structure are known to satisfy the requirements to achieve both features. Using first-principles density functional theory (DFT), we investigated the electrochemical stability of garnet-type Li(x)La(3)M(2)O(12) (M = Ti, Zr, Nb, Ta, Sb, Bi; x = 5 or 7) materials against Li metal. We found that the electrochemical stability of such materials depends on their composition and structure. The electrochemical stability against Li metal was improved when a cation M was chosen with a low effective nuclear charge, that is, with a high screening constant for an unoccupied orbital. In fact, both our computational and experimental results show that Li(7)La(3)Zr(2)O(12) and Li(5)La(3)Ta(2)O(12) are inert to Li metal. In addition, the linkage of MO(6) octahedra in the crystal structure affects the electrochemical stability. For example, perovskite-type La(1/3)TaO(3) was found, both experimentally and computationally, to react with Li metal owing to the corner-sharing MO(6) octahedral network of La(1/3)TaO(3), even though it has the same constituent elements as garnet-type Li(5)La(3)Ta(2)O(12) (which is inert to Li metal and features isolated TaO(6) octahedra). PMID:22711381

Nakayama, Masanobu; Kotobuki, Masashi; Munakata, Hirokazu; Nogami, Masayuki; Kanamura, Kiyoshi

2012-06-19

335

Urocortin promotes the development of vasculitis in a rat model of thromboangiitis obliterans via corticotrophin-releasing factor type 1 receptors  

PubMed Central

Background and purpose: Urocortin is a locally expressed pro-inflammatory peptide. Here we have examined the effects of urocortin on sodium laurate-induced peripheral arterial vasculitis in rats, modelling the mechanisms of thromboangiitis obliterans (TAO). Experimental approach: Peripheral vasculitis in rats was induced by sodium laurate and graded by gross appearance on the 12th day after injection. Histological changes in rat femoral arteries were assessed by histopathology and transmission electron microscopy. Blood cell counts, blood rheology, blood coagulation and plasma urocortin, thromboxane B2, prostaglandin E2 and soluble intercellular adhesion molecule-1 levels were measured. Expression of urocortin, corticotrophin-releasing factor (CRF1/2) receptors, cyclooxygenase (COX)-2 and intercellular adhesion molecule-1 (ICAM-1) at both mRNA and protein levels were determined by RT-PCR and Western blot. Key results: Rats showed grossly visible signs and symptoms of TAO on the 12th day after sodium laurate injection. In these rats, blood was in a hypercoagulable state; plasma urocortin, prostaglandin E2 and soluble intercellular adhesion molecule-1 levels were elevated; and the expression of urocortin, CRF1 and CRF1?-receptors, COX-2 and ICAM-1 in rat femoral arteries were markedly increased. Exogenous urocortin, given for 12 days after sodium laurate, exacerbated the hypercoagulable state and augmented expression of CRF1?-receptors, COX-2 and ICAM-1. These effects were abolished by a CRF1-receptor antagonist, NBI-27914, or a non-selective CRF-receptor antagonist, astressin, but not by the CRF2-receptor antagonist, antisauvagine-30, given with exogenous urocortin. Conclusion and implications: Urocortin exacerbated the hypercoagulable state and vasculitis in a model of TAO induced by sodium laurate in rats, via CRF1-receptors. COX-2 and ICAM-1 might also have contributed to this exacerbation.

Xu, Youhua; Zhang, Rongjian; Chen, Jie; Zhang, Qichun; Wang, Juejin; Hu, Jue; Guan, Xiaowei; Jin, Lai; Fu, Hong; Gui, Bo; Guo, Yuanyuan; Li, Shengnan

2009-01-01

336

Non-gaussianity and Statistical Anisotropy in Cosmological Inflationary Models  

NASA Astrophysics Data System (ADS)

We study the statistical descriptors for some cosmological inflationary models that allow us to get large levels of non-gaussianity and violations of statistical isotropy. Basically, we study two different class of models: a model that include only scalar field perturbations, specifically a subclass of small-field slow-roll models of inflation with canonical kinetic terms, and models that admit both vector and scalar field perturbations. We study the former to show that it is possible to attain very high, including observable, values for the levels of non-gaussianity f_{NL} and tao_{NL} in the bispectrum B_zeta and trispectrum T_zeta of the primordial curvature perturbation zeta respectively. Such a result is obtained by taking care of loop corrections in the spectrum P_zeta, the bispectrum B_zeta and the trispectrum T_zeta . Sizeable values for f_{NL} and tao_{NL} arise even if zeta is generated during inflation. For the latter we study the spectrum P_zeta, bispectrum B_zeta and trispectrum $T_zeta of the primordial curvature perturbation when zeta is generated by scalar and vector field perturbations. The tree-level and one-loop contributions from vector field perturbations are worked out considering the possibility that the one-loop contributions may be dominant over the tree level terms. The levels of non-gaussianity f_{NL} and tao_{NL}, are calculated and related to the level of statistical anisotropy in the power spectrum, g_zeta . For very small amounts of statistical anisotropy in the power spectrum, the levels of non-gaussianity may be very high, in some cases exceeding the current observational limit.

Valenzuela-Toledo, Cesar A.

2010-04-01

337

The Teleost Anatomy Ontology: Anatomical Representation for the Genomics Age  

PubMed Central

The rich knowledge of morphological variation among organisms reported in the systematic literature has remained in free-text format, impractical for use in large-scale synthetic phylogenetic work. This noncomputable format has also precluded linkage to the large knowledgebase of genomic, genetic, developmental, and phenotype data in model organism databases. We have undertaken an effort to prototype a curated, ontology-based evolutionary morphology database that maps to these genetic databases (http://kb.phenoscape.org) to facilitate investigation into the mechanistic basis and evolution of phenotypic diversity. Among the first requirements in establishing this database was the development of a multispecies anatomy ontology with the goal of capturing anatomical data in a systematic and computable manner. An ontology is a formal representation of a set of concepts with defined relationships between those concepts. Multispecies anatomy ontologies in particular are an efficient way to represent the diversity of morphological structures in a clade of organisms, but they present challenges in their development relative to single-species anatomy ontologies. Here, we describe the Teleost Anatomy Ontology (TAO), a multispecies anatomy ontology for teleost fishes derived from the Zebrafish Anatomical Ontology (ZFA) for the purpose of annotating varying morphological features across species. To facilitate interoperability with other anatomy ontologies, TAO uses the Common Anatomy Reference Ontology as a template for its upper level nodes, and TAO and ZFA are synchronized, with zebrafish terms specified as subtypes of teleost terms. We found that the details of ontology architecture have ramifications for querying, and we present general challenges in developing a multispecies anatomy ontology, including refinement of definitions, taxon-specific relationships among terms, and representation of taxonomically variable developmental pathways.

Dahdul, Wasila M.; Lundberg, John G.; Midford, Peter E.; Balhoff, James P.; Lapp, Hilmar; Vision, Todd J.; Haendel, Melissa A.; Westerfield, Monte; Mabee, Paula M.

2010-01-01

338

Enhanced Monitoring for the Eastern Pacific Investigation of Climate Processes (EPIC) Experiment  

NASA Astrophysics Data System (ADS)

The Eastern Pacific Investigation of Climate Processes (EPIC) is a five-year experiment designed to improve understanding of the intertropical convergence zone (ITCZ), its interactions with the cold tongue of water that extends along the equator, and the physics of the cloud deck that forms over the cool waters off South America. EPIC fieldwork began in 1999 and involves short-term process studies, embedded within longer-term (3-4 years) enhanced monitoring, built on the El Niño-Southern Oscillation (ENSO) observing system. As part of EPIC enhanced monitoring, an IMET mooring was deployed at 20°S, 85°W in the stratus deck region, and the easternmost (95°W) Tropical Atmosphere and Ocean (TAO) line of moorings was enhanced with additional sensors and moorings. With 10 EPIC-enhanced TAO moorings between 8°S, 95°W and 12°N, 95°W, the 95°W mooring line provides a picket fence of time series of heat, moisture and momentum fluxes and upper ocean temperature, salinity, and horizontal currents from the stratocumulus region, across the cold tongue / ITCZ complex and into the northeastern tropical Pacific warm pool. Six-monthly TAO maintenance cruises were also specially equipped to monitor air-sea fluxes and boundary layer properties. In this presentation we combine ship transect measurements with moored time series to show the structure and evolution of the cold tongue / ITCZ complex. In addition, southern moorings along 95°W are compared with the 20°S, 85°W stratus mooring to show the meridional extent of the cold season stratiform. Implications for understanding and modeling eastern tropical Pacific ocean-atmosphere interactions will be discussed.

Cronin, M. F.; Bond, N.; Fairall, C.; Hare, J.; McPhaden, M. J.; Weller, R. A.

2002-12-01

339

Slip Rate Determination of Thrusts Along the Edge of NE Tibet From in situ-Produced Cosmogenic Nuclides  

NASA Astrophysics Data System (ADS)

The Qilian Shan forms a seismically active fold-and-thrust-belt along the NE margin of the Tibetan Plateau that evolved during the Neogene-Quaternary and continues to advance north-northeastward (Meyer et al., 1998; Tapponnier et al., 2001). Active thrust faults transecting Late Pleistocene alluvial fan deposits form spectacular fault scarps that are locally incised by rivers which form flights of terraces. By combining structural investigations, satellite imagery, topographic profiling, surface exposure, and luminescence dating we have determined slip rates for several thrust faults (Hetzel et al. 2002, 2004a,b). Our results are consistent with geologic and GPS constraints, which suggest that NNE-directed shortening across the northeastern Tibetan Plateau is distributed on several active faults with a total shortening rate of about 4 to 10 mm/yr. References Hetzel, R., S. Niedermann, M. Tao, P.W. Kubik, S. Ivy-Ochs, B. Gao, M.R. Strecker (2002a), Nature, 417, 428-432. Hetzel, R., M. Tao, S. Niedermann, M.R. Strecker, S. Ivy-Ochs, P.W. Kubik, B. Gao (2004a), Terra Nova 16, 157-162. Hetzel R., M. Tao, S. Stokes, S. Niedermann, S. Ivy-Ochs, G. Bo, M.R. Strecker, P.W. Kubik (2004b), Tectonics 23, TC6006, doi:10.1029/2004TC001653. Meyer, B., P. Tapponnier, L. Bourjot, F. Metivier, Y. Gaudemer, G. Peltzer, G. Shunmin, C. Zhitai (1998), Geophys. J. Int., 135, 1-47. Tapponnier, P., Z. Xu, F. Roger, B. Meyer, N. Arnaud, G. Wittlinger, J. Yang (2001), Science, 294, 1671-1677.

Hetzel, R.; Niedermann, S.; Tao, M.; Ivy-Ochs, S.; Stokes, S.; Strecker, M. R.; Kubik, P. W.

2005-12-01

340

Substitutional mechanism of Ni into the wide-band-gap semiconductor InTaO4 and its implications for water splitting activity in the wolframite structure type.  

PubMed

The mechanism of Ni substitution into the oxide semiconductor InTaO(4) has been studied through a combination of structural and spectroscopic techniques, providing insights into its previously reported photoactivity. Magnetic susceptibility and X-ray absorption near-edge spectroscopy (XANES) measurements demonstrate that nickel is divalent within the host lattice. The combined refinement of synchrotron X-ray and neutron powder diffraction data indicates that the product of Ni doping has the stoichiometry of (In(1-x)Ni(2x/3)Ta(x/3))TaO(4) with a solubility limit of x ? 0.18, corresponding to 12% Ni on the In site. Single-phase samples were only obtained at synthesis temperatures of 1150 °C or higher due to the sluggish reaction mechanism that is hypothesized to result from small free energy differences between (In(1-x)Ni(2x/3)Ta(x/3))TaO(4) compounds with different x values. Undoped InTaO(4) is shown to have an indirect band gap of 3.96 eV, with direct optical transitions becoming allowed at photon energies in excess of 5.1 eV. Very small band-gap reductions (less than 0.2 eV) result from Ni doping, and the origin of the yellow color of (In(1-x)Ni(2x/3)Ta(x/3))TaO(4) compounds instead results from a weak (3)A(2g) ? (3)T(1g) internal d ? d transition not associated with the conduction or valence band that is common to oxide compounds with Ni(2+) in an octahedral environment. PMID:22530995

Malingowski, Andrew C; Stephens, Peter W; Huq, Ashfia; Huang, Qingzhen; Khalid, Syed; Khalifah, Peter G

2012-04-24

341

Neutron diffusion in a randomly inhomogeneous multiplying medium with random phase approximation  

NASA Astrophysics Data System (ADS)

Neutron diffusion in a randomly inhomogeneous multiplying medium is studied. By making use of a random phase assumption we show that the average neutron density approximately satisfies an integral equation in Fourier space, which is solved using Kummer functions. We used multi-dimensional formulation. In the case of one dimension, we obtain the result of Rosenbluth and Tao for the mean total density for large t. In the three-dimensional case, a closed form of solution is derived for the mean total neutron density. Its asymptotic behavior is also investigated for large t.

Imre, Kaya; Akcasu, A. Ziya

2012-06-01

342

Characterization of zinc-modified lithium tantalate thin films fabricated by chemical solution deposition method  

Microsoft Academic Search

Zinc-substituted lithium tantalate thin films were fabricated for improving the electrical resistivity by compensating the\\u000a valence of lattice defects in LiTaO3 crystal. The films with the chemical composition of (Li1.00-x\\u000a Zn\\u000a x\\u000a )TaO3 were fabricated on (111)Pt\\/TiO2\\/SiO2\\/(100)Si substrate by a chemical solution deposition technique using metal-organic precursors. Dense films consisting of a\\u000a ilumenite-type crystalline phase were deposited by spin coating

Hiroshi Uchida; Katsumi Onofuji; Hiroshi Funakubo; Seiichiro Koda

2007-01-01

343

High-density limit of the Perdew-Burke-Ernzerhof generalized gradient approximation and related density functionals  

SciTech Connect

We point out a simplifying but mildly inconsistent assumption of the Perdew-Burke-Ernzerhof (PBE) correlation functional, which should be corrected when evaluating the high-density limit of the PBE energy for nonsinglet systems under uniform density scaling. The discussion also concerns high-density limits of all density functionals that use PBE as an ingredient, including the Tao-Perdew-Staroverov-Scuseria (TPSS) approximation. We revisit the nonrelativistic correlation energies of isoelectronic atomic ions in the limit of infinite nuclear charge and explain small discrepancies between the PBE and TPSS values of these limits existing in the literature.

Staroverov, Viktor N.; Scuseria, Gustavo E.; Perdew, John P.; Davidson, Ernest R.; Katriel, Jacob [Department of Chemistry, Rice University, Houston, Texas 77005 (United States); Department of Physics and Quantum Theory Group, Tulane University, New Orleans, Louisiana 70118 (United States); Department of Chemistry, University of Washington, Seattle, Washington 98195 (United States); Department of Chemistry, Technion-Israel Institute of Technology, Haifa 32000 (Israel)

2006-10-15

344

Statistical Physics of Economic Systems: a Survey for Open Economies  

NASA Astrophysics Data System (ADS)

We extend the theoretical framework of an independent economy developed by Tao [Phys. Rev. E 82 (2010) 036118] so as to include multiple economies. Since the starting point of our framework is on the basis of the theory of the competitive markets of traditional economics, this framework shall be suitable for any free market. Our study shows that integration of world economies can decrease trade friction among economic systems, but may also cause a global economic crisis whenever economy disequilibrium occurs in any one of these economic systems.

Tao, Yong; Chen, Xun

2012-05-01

345

Four decades of DNA repair: from early insights to current perspectives.  

PubMed

A brief history of the evolution of the DNA repair field over the past four decades is presented, as documented through the Proceedings from a selected series of five scientific meetings, beginning with the 1965 Radiation Microbiology Conference, held at the University of Chicago with only 40 participants, and extending through the 1988 UCLA Symposium on "Mechanisms and Consequences of DNA Damage Processing", convened in Taos, New Mexico, with over 400 participants. The published proceedings and recorded discussions from these early conferences contain notable insights, of which many have turned out to be remarkably clairvoyant while others must be reevaluated in light of recent discoveries and developments in the field. PMID:14726012

Hanawalt, Philip C

2003-11-01

346

Inside cover, volume 34, issue 26.  

PubMed

The cover depicts a Stone-Wales (SW) defective single-walled carbon nanotube (SWNT) surrounded with several 1,3- dipoles such as azomethine ylide and nitrone. Using a two-layered ONIOM method by Tao Yang, Xiang Zhao, and Shigeru Nagase on page 2223, 1,3-dipolar cycloadditions of several 1,3-dipoles upon SW defective and defect-free SWNTs are systematically studied. Compared with defect-free SWNTs, the SW defective SWNTs exhibit the higher chemical reactivity. The larger the diameter of the SWNT, the lower chemical reactivity the SW defective SWNT shows. PMID:24038097

2013-10-01

347

Band-gap states and ferroelectric restoration in strontium bismuth tantalate  

NASA Astrophysics Data System (ADS)

By means of photoluminescence (PL) and sub-band-gap (sub-Eg) optical illumination, the degradation and restoration of ferroelectric properties in strontium bismuth tantalate thin films have been investigated, and the existence of band-gap states is demonstrated. It is shown that the suppression and recovery of ferroelectricity are closely correlated with the change of PL intensity, since both switchable polarization and PL are related to Ta5+ ions in the TaO6 octahedron. Furthermore, the electric-field-induced restoration increases dramatically by the aid of sub-band-gap light (2.5 eV<=h?<=Eg) illumination absorbed in band-gap states.

Li, Biao; Koch, F.; Chu, L.

2001-02-01

348

Two high-temperature paraelectric phases in Sr0.85Bi2.1Ta2O9  

NASA Astrophysics Data System (ADS)

Sr0.85Bi2.1Ta2O9 is shown, by Rietveld refinement of powder neutron-diffraction data, to undergo two phase transitions at elevated temperature. The low-temperature ferroelectric phase (space group A21am) transforms to a paraelectric phase (Amam) at Tc~375°C. This phase does not transform to the expected tetragonal phase (I4/mmm) until T~550°C. The transition from A21am to Amam involves not only loss of the displacive mode along the polar a axis, but also loss of a TaO6 octahedral tilt mode around the c axis.

Hervoches, C. H.; Irvine, J. T. S.; Lightfoot, P.

2001-09-01

349

Studying of sensitivity of the couple model on data assimilation in the tropical zone of Pacific ocean  

NASA Astrophysics Data System (ADS)

Numerical experiments based on the coupled model "ECHAM-HOPE" are considered and analyzed in the paper. Initial fields for computations performed over time-periods from one month up to one year have been constrained with TOGA-TAO temperature profiles assimilation. The perturbations of the initial fields and their propagation are analyzed after certain time-intervals of computations. It is shown that the maximum impact of perturbations is localized at the selected regions of the World Ocean, such as "energy active zones" in the middle latitudes and in the tropical Pacific. The mechanism of the transformation of these perturbations is also investigated. Different statistics of the ensemble experiments are presented.

Tuchkova, Natalia; Belyaev, Konstantin; Cubasch, Ulrich

2010-05-01

350

Ocean and Weather Data Navigator  

NSDL National Science Digital Library

This interactive map viewer allows users to visualize and download in-situ oceanographic or atmospheric data from a Dapper OpenDap server. The map can be zoomed or dragged, with an in-situ station layer that allows selection of data stations, and a plot window that allows users to plot data from one or more stations. Datasets (temperature, salinity, current, chemistry) include realtime global Argo data, Tropical Atmosphere Ocean (TAO) Project El Nino buoy data, time series data from the National Data Buoy Center, Global Summary of the Day data, and other collections of oceanographic hydrographic and time series data.

351

Phase stability of cubic pyrochlore rare earth tantalate pinning additives in YBa2Cu3O7- superconductor  

SciTech Connect

Phase stability of cubic-pyrochlore-structured RE3TaO7 (RTO, where RE = rare earth elements) pinning additives in YBa2Cu3O7- (YBCO) superconductor and the pinning properties influenced by RTO addition into YBCO films were investigated. RTO completely reacts with YBCO and is converted to cubic-double-perovskite-structured Ba2RETaO6 (BRETO), a more thermodynamically stable tantalate phase within YBCO. In RTO-doped YBCO films, BRETO self-assembled nanocolumnns align along the c-axis of the film and play a major role in the improvement of flux pinning and Jc performance over wide magnetic field and angular ranges.

Wee, Sung Hun [ORNL; Cantoni, Claudia [ORNL; Zuev, Yuri L [ORNL; Specht, Eliot D [ORNL; Goyal, Amit [ORNL

2012-01-01

352

[The first experience in using the stabilized hyaluronic acid preparation to correct lagophthalmos].  

PubMed

The authors report the results of the first experience in using the stabilized hyaluronic acid preparation in patients with lagopthalmos in the presence of facial nerve palsy and thyroid eye disease and resultant keratopathy of varying degrees. The study included 21 patients, including 15 patients with facial nerve palsy and 6 with endocrine ophthalmopathy. The gel was injected externally to the levator aponeurosis and/or intramuscular, and/or under the pretarsal portion of the orbicularis oculi muscle, and/or subcutaneously. The use of this method led to a significant reduction of lagophthalmos and to a considerable corneal improvement. That of this procedure permitted avoidance of surgical intervention in some patients. The mean follow-up period after injection was 11.2 months (range 6-24 months). PMID:20645575

Grusha, Ia O; Ismailova, D S; Ivanchenko, Iu F; Agafonova, E I

353

[Treatment of pretibial myxoedema with pentoxifylline].  

PubMed

Pretibial myxoedema is a rare symptom of Graves' disease. Histological studies detected mucopolysaccharide and glycosaminoglycan accumulation, and the role of anti-TSH receptor antibodies has been suggested. In this paper the authors present the case of a 34-year-old male patient with pretibial myxoedema treated successfully with pentoxifylline. In his case history multiple autoimmune diseases (type 1 diabetes mellitus, Graves' disease with severe ophthalmopathy) concomitantly occurred. His severe pretibial myxoedema was undiagnosed and untreated at the time of admission. Because of his diabetes, steroid was contraindicated, which made the choice of the treatment more difficult. He received first intradermal, then intravenous and, finally, oral pentoxifylline, which resulted in a regression of the dermatological symptoms. The beneficial effect of pentoxifylline might be explained by its inhibitory effect of proinflammatory cytokines and proliferation of fibroblasts, and the production of glycosaminoglycan. It was concluded that pentoxifylline can be an effective and safe treatment of pretibial myxoedema. PMID:23089171

Türke, Boglárka; Balázs, Csaba

2012-10-28

354

Thyroid disease  

SciTech Connect

Presenting a multidisciplinary approach to the diagnosis and treatment of thyroid disease, this volume provides a comprehensive picture of current thyroid medicine and surgery. The book integrates the perspectives of the many disciplines that deal with the clinical manifestations of thyroid disorders. Adding to the clinical usefulness of the book is the state-of-the-art coverage of many recent developments in thyroidology, including the use of highly sensitive two-site TSH immunoradionetric measurements to diagnose thyroid activity; thyroglobulin assays in thyroid cancer and other diseases; new diagnostic applications of MRI and CT; treatment with radionuclides and chemotherapy; new developments in thyroid immunology, pathology, and management of hyperthyroidism; suppressive treatment with thyroid hormone; and management of Graves' ophthalmopathy. The book also covers all aspects of thyroid surgery, including surgical treatment of hyperthyroidism; papillary, follicular, and other carcinomas; thyroidectomy; and prevention and management of complications.

Falk, S.

1990-01-01

355

The use of autogenous fascia lata to correct lid and orbital deformities.  

PubMed Central

Autogenous and homologous fascia lata have been used to correct many problems in ophthalmic surgery. This paper has described the use of autogenous fascia late to correct lid retraction secondary to thyroid ophthalmopathy, cicatricial entropion and extruding orbital implants. The surgical procedures have been briefly discussed, as well as the presentation of one clinical example of each procedure the pathologic and immunologic aspects of fascia lata grafts will be reported at a later date. Images FIGURE 1 A FIGURE 1 B FIGURE 1 C FIGURE 1 D FIGURE 1 E FIGURE 1 F FIGURE 2 A FIGURE 2 B FIGURE 2 C FIGURE 2 D FIGURE 3 A FIGURE 3 B FIGURE 3 C FIGURE 4 FIGURE 5 A FIGURE 5 B FIGURE 5 C FIGURE 6 A FIGURE 6 B FIGURE 6 C FIGURE 6 D FIGURE 7 A FIGURE 7 B FIGURE 7 C

Flanagan, J C; Campbell, C B

1981-01-01

356

Dilated episcleral veins with secondary open angle glaucoma  

PubMed Central

We report a case of dilated episcleral vein with secondary open angle glaucoma. A 65-year-old female presented with redness of both the eyes without any prior systemic history. Her ocular examination revealed dilated episcleral veins and a high intraocular pressure (IOP) of 38 mm Hg in the right eye. Systemic examination was negative for carotid cavernous fistula, low-grade dural arteriovenous fistula, dysthyroid ophthalmopathy, and primary pulmonary hypertension. During follow-up, her IOP remained in high thirties despite maximum medications. She underwent right eye trabeculectomy with partial thickness sclerectomy with sclerotomy. In the beginning, the sclerotomy incision was not deepened into the suprachoroidal space. She developed choroidal effusion during surgery and the sclerotomy was deepened into suprachoroidal space and straw color fluid was drained. Postoperatively, she developed choroidal effusion, which resolved with conservative management. This case highlights the importance of sclerotomy in such cases of high episcleral venous pressure.

Parikh, Rajul S; Desai, Savari; Kothari, Kulin

2011-01-01

357

Stickler syndrome, ocular-only variants and a key diagnostic role for the ophthalmologist  

PubMed Central

The entity described by Gunnar Stickler, which included hereditary arthro-ophthalmopathy associated with retinal detachment, has recently been recognised to consist of a number of subgroups, which might now more correctly be referred to as the Stickler syndromes. They are the most common clinical manifestation of the type II/XI collagenopathies and are the most common cause of inherited rhegmatogenous retinal detachment. This review article is intended to provide the ophthalmologist with an update on current research, subgroups, and their diagnosis together with a brief overview of allied conditions to be considered in the clinical differential diagnosis. We highlight the recently identified subgroups with a high risk of retinal detachment but with minimal or absent systemic involvement—a particularly important group for the ophthalmologist to identify.

Snead, M P; McNinch, A M; Poulson, A V; Bearcroft, P; Silverman, B; Gomersall, P; Parfect, V; Richards, A J

2011-01-01

358

Management of the nontoxic multinodular goiter in Latin America: comparison with North America and Europe, an electronic survey.  

PubMed

To assess diagnostic and therapeutic approaches to nontoxic multinodular goiter and to compare them with previously reported American Thyroid Association (ATA) and European Thyroid Association (ETA) surveys, an online questionnaire was distributed to Latin American Thyroid Society (LATS) members. An index case was presented (42-yr-old woman with an enlarged, irregular, nontender, 50- to 80-g thyroid and no clinical suspicion of malignancy or dysfunction), and 11 variations were proposed to evaluate how each alteration would affect management. We obtained 148 responses (response rate, 50%). In the index case, the most used blood tests were TSH (96%), antithyroid peroxidase antibodies (76%), and free T(4) (64%); 5% included a calcitonin assay. Nearly 90% would perform ultrasound, and only 16% used scintigraphy. Fine needle biopsy was indicated by 88%, with ultrasound guidance in 75% of times. For treatment, observation was preferred by 39%, surgery by 28%, levothyroxine by 21%, and radioiodine by 7% (60% with recombinant TSH prestimulation). A suppressed TSH level prompted 45% of the respondents to recommend radioiodine, whereas 70-78% indicated surgery in the presence of a large goiter or suspicion of malignancy. In conclusion, no consensus exists concerning the ideal management of nontoxic goiter among LATS members, in agreement with previous ATA and ETA surveys. Levothyroxine therapy is less used by LATS than by ATA or ETA members, and a more aggressive therapeutic strategy is generally preferred by members of LATS and ETA compared with ATA. PMID:15483102

Diehl, Leandro Arthur; Garcia, Valdinei; Bonnema, Steen J; Hegedüs, Laszlo; Albino, Claudio Cordeiro; Graf, Hans

2004-10-13

359

Thyroid nodules: a review of current guidelines, practices, and prospects.  

PubMed

In 2006, two major society-sponsored guidelines and one major consensus statement for thyroid diagnosis and management were published by: the American Association of Clinical Endocrinologists/Associazione Medici Endocrinologi (AACE/AME); the American Thyroid Association (ATA); and the European Thyroid Association (ETA). A careful review of these guidelines reveals that despite many similarities, significant differences are also present, likely reflecting differences in practice patterns, interpretation of existing data, and availability of resources in different regions. The methodology of the guidelines is similar, but a few differences in the rating scale make a rapid comparison of the strength of both evidence and recommendations difficult for the use in current clinical practice. Some recommendations are based mostly on experts' opinion. Thus, a same recommendation may be based on a different evidence; on the other hand, sometimes the same evidence may induce a different recommendation. Therefore, efforts are needed to produce a few high-quality clinical studies to close the evidence gaps in the still controversial fields of thyroid disease and to create a joint task force of the most authoritative societies in the field of thyroid disease in order to reach a common document for clinical practice recommendations. PMID:18728120

Gharib, H; Papini, E; Paschke, R

2008-08-26

360

[Results of serological reactions in patients with presumptive diagnosis of toxoplasmosis].  

PubMed

Even though Toxoplasma gondii is an ubiquitous parasite that can effect most of human structures and organs, not all clinical manifestations suggestive of being produced by it are caused by this protozoon. For these reasons sera samples of patients suspected of having toxoplasmosis are sent to the laboratory for detecting specific antibodies which would facilitate the differential diagnosis. Thus, 716 sera from suspected patients, mainly from the Metropolitan Region of Chile, were sent to the Parasitology Laboratory of Chile University in order to carry out in them, specific serological tests for toxoplasmosis: indirect hemagglutination test (IHAT), Sabin Feldman reaction (SFT) and complement fixation test (CFT). Were considered positive: IHAT and/or SFT with titers > or = 1:16 and CFT with titer > or = 1:5. The pathologies for demanding these serological tests were obstetrical problems 210 (29.3%), congenital problems 193 (27.0%), ophthalmopathies 81 (11.3%), adenopathies 77 (10.8%), AIDS 67 (9.4%), myocardiopathies 46 (6.4%) and miscellaneous 42 (5.9%). The positivity found in these sera was higher in ophthalmopathies (61.7%), followed by obstetrical problems, miscellaneous problems, myocardiopathies and AIDS (50.7-52.4%), less frequent was the positivity in adenopathies (35.1%) and congenital problems (23.1%). In general, the 43.7% of positivity for toxoplasmosis found in these patients is higher than the 37.0% found in the general population. High titers of IHAT and SFT plus positive CFT was found in 13-fold higher proportion than in the general population. PMID:1844141

Castro, M; Contreras, M C; Salinas, P

361

[Immunodiagnosis in 647 suspected clinical cases of toxoplasmosis].  

PubMed

Though Toxoplasma gondii can cause severe pathology in human, in most of the cases it produces only asymptomatic infection. So, it is important to dispose some methods capables to discriminate between acute and chronic infections. An indirect hemagglutination test (IHAT), dye test (DT) and complement fixation test (CFT) were performed in 647 sera from patients suspected of having toxoplasmosis infection. IHAT and DT titer > or = 4 and CFT > or = 5 were considered positive. Titers were classified as follows: low (4-16), median (64-512) and high (> or = 1000) for IHAT and DT. The pathologies for demanding these serological tests were: adenopathies (58), nephropathies (72), neuropathies (30), obstetrical problems (65), opthalmopathies (147), AIDS (237) and miscellaneous (37). Global positivity of 49.5% and 4.5% for IHAT/DT and CFT respectively were found. The positivity for the different groups were: adenopathies (48.3% and 13.8%), nephropathies (43.1% and 1.4%), neuropathies (26.7% and 3.3%), obstetrical problems (40.0% and 0.0%), ophthalmopathies (59.9% and 8.2%), AIDS (52.1% and 2.5%) and miscellaneous (40.5% and 2.7%) for IHAT/DT and CFT respectively. Low and median titers for IHAT/DT were found in 81.3% of cases. A high agreement in frequency of concordant and discordant titers of IHAT/DT and CFT, indicating a recent or acute infection was observed. This fact was more relevant in adenopathies, ophthalmopathies (uveitis) and AIDS groups. PMID:9640680

Contreras, M C; Gallo, S; Salinas, P; Rugiero, E; Sandoval, L; Schenone, H

362

Association of single-nucleotide polymorphisms in the STAT3 gene with autoimmune thyroid disease in Chinese individuals.  

PubMed

The aim of this study was to investigate the association between signal transducer and activator of transcription 3 (STAT3) polymorphisms and autoimmune thyroid diseases and clinical features. We genotyped six single-nucleotide polymorphisms (SNPs) rs1053005, rs2293152, rs744166, rs17593222, rs2291281, and rs2291282 of STAT3 gene in 667 patients with autoimmune thyroid disease (417 Graves' disease (GD) and 250 Hashimoto's thyroiditis (HT)) and 301 healthy controls. The allele A from rs1053005 was significantly less frequent in both GD and HT patients (P?=?0.0024, OR?=?0.6958, 95%CI?=?0.5508-0.8788; P?=?0.0091, OR?=?0.7013, 95%CI?=?0.5397-0.9112, respectively). The AA genotype of rs1053005 was less in GD and HT patients too (P?=?0.0025,OR?=?0.6278, 95%CI?=?0.466-0.847) and (P?=?0.0036,OR?=?0.601, 95%CI?=?0.428-0.843). The allele G from rs17593222 increased the susceptibility to the ophthalmopathy development both in autoimmune thyroid disease (AITD) and GD patients (P?=?0.0007, OR?=?3.980, 95%CI?=?1.871-8.464; P?=?0.0081, OR?=?3.378, 95%CI?=?1.441-7.919, respectively). The allele A and AA genotype of SNP rs1053005 may protect individuals from the susceptibility to AITD and their frequency decreased in AITD patients. In addition, the allele G of rs17593222 may increase the ophthalmopathy risk in AITD patients. Our findings suggest the existence of association between STAT3 gene and AITD, thus adding STAT3 gene to the list of the predisposing genes to AITD. PMID:24081513

Xiao, Ling; Muhali, Fatuma-Said; Cai, Tian-Tian; Song, Rong-Hua; Hu, Renming; Shi, Xiao-Hong; Jiang, Wen-Juan; Li, Dan-Feng; He, Shuang-Tao; Xu, Jian; Zhang, Jin-An

2013-10-01

363

Amorphous Ta-nanocrystalline RuOx diffusion barrier for lower electrode of high density memory devices  

NASA Astrophysics Data System (ADS)

The effects of the amount of RuO2 added in the Ta film on the electrical properties of a Ta-RuO2 diffusion barrier were investigated using n++-poly-Si substrate at a temperature range of 650-800°C. For the Ta layer prepared without RuO2 addition, Ta2O5 phase formed after annealing at 650°C by reaction between Ta and external oxygen, leading to a higher total resistance and a non-linear I-V curve. Meanwhile, in the case of the Ta film being deposited with RuO2 incorporation, not only a lower total resistance and ohmic characteristics exhibited, but also the bottom electrode structure was retained up to 800°C, attributing to the formation of a conductive RuO2 crystalline phase in the barrier film by reaction with the indiffused oxygen because of a Ta amorphous structure formed by chemially strong Ta-O or Ta-Ru-O bonds and a large amount of conductive RuO2 added. Since a kinetic barrier for nucleation in formation of the crystalline Ta2O5 phase from an amorphous Ta(O) phase is much higher than that of crystalline RuO2 phase from nanocrystalline RuOx phase, the formation of the RuO2 phase by reaction between the indiffused oxygen and the RuOx nanocrystallites is kinetically more favorable than that of Ta2O5 phase.

Yoon, Dong-Soo; Baik, Hong Koo; Lee, Sung-Man; Roh, Jae Sung

2001-05-01

364

In situ observation of filamentary conducting channels in an asymmetric Ta2O5-x/TaO2-x bilayer structure.  

PubMed

Electrically induced resistive switching in metal insulator-metal structures is a subject of increasing scientific interest because it is one of the alternatives that satisfies current requirements for universal non-volatile memories. However, the origin of the switching mechanism is still controversial. Here we report the fabrication of a resistive switching device inside a transmission electron microscope, made from a Pt/SiO2/a-Ta2O5-x/a-TaO2-x/Pt structure, which clearly shows reversible bipolar resistive switching behaviour. The current-voltage measurements simultaneously confirm each of the resistance states (set, reset and breakdown). In situ scanning transmission electron microscope experiments verify, at the atomic scale, that the switching effects occur by the formation and annihilation of conducting channels between a top Pt electrode and a TaO2-x base layer, which consist of nanoscale TaO1-x filaments. Information on the structure and dimensions of conductive channels observed in situ offers great potential for designing resistive switching devices with the high endurance and large scalability. PMID:24008898

Park, Gyeong-Su; Kim, Young Bae; Park, Seong Yong; Li, Xiang Shu; Heo, Sung; Lee, Myoung-Jae; Chang, Man; Kwon, Ji Hwan; Kim, M; Chung, U-In; Dittmann, Regina; Waser, Rainer; Kim, Kinam

2013-09-01

365

In situ observation of filamentary conducting channels in an asymmetric Ta2O5?x/TaO2?x bilayer structure  

NASA Astrophysics Data System (ADS)

Electrically induced resistive switching in metal insulator-metal structures is a subject of increasing scientific interest because it is one of the alternatives that satisfies current requirements for universal non-volatile memories. However, the origin of the switching mechanism is still controversial. Here we report the fabrication of a resistive switching device inside a transmission electron microscope, made from a Pt/SiO2/a-Ta2O5?x/a-TaO2?x/Pt structure, which clearly shows reversible bipolar resistive switching behaviour. The current–voltage measurements simultaneously confirm each of the resistance states (set, reset and breakdown). In situ scanning transmission electron microscope experiments verify, at the atomic scale, that the switching effects occur by the formation and annihilation of conducting channels between a top Pt electrode and a TaO2?x base layer, which consist of nanoscale TaO1?x filaments. Information on the structure and dimensions of conductive channels observed in situ offers great potential for designing resistive switching devices with the high endurance and large scalability.

Park, Gyeong-Su; Kim, Young Bae; Park, Seong Yong; Li, Xiang Shu; Heo, Sung; Lee, Myoung-Jae; Chang, Man; Kwon, Ji Hwan; Kim, M.; Chung, U.-In; Dittmann, Regina; Waser, Rainer; Kim, Kinam

2013-09-01

366

The IAU Early Japanese Radio Astronomy Project: A Progress Report  

NASA Astrophysics Data System (ADS)

Japan was one of those nations that make an early start in radio astronomy, when solar observations began at both the Tokyo Astronomical Observatory (TAO) and at Osaka University in 1949. The research at the TAO accelerated during the 1950s and 1960s under the capable direction of Professor Hatanaka, while an equally-vibrant program was developed independently at Toyokawa by Professor Tanaka from Nagoya University. In this paper, after briefly describing the Osaka University initiative we will outline the instruments developed at Toyokawa and Mitaka, review the research programs carried out with them and introduce the scientific staff who played so important a role in the early development of Japanese radio astronomy. Following the success of the WG's Early French Radio Astronomy Project (seven papers were published), an ambitious IAU project to systematically document early developments in Japanese radio astronomy and publish the results in a series of research papers in the Journal of Astronomical History and Heritage was launched in December 2010. Further research visits to Tokyo were made by the second author in 2011 and 2012, and two papers have now been completed and a start made on a third.

Ishiguro, Masato; Orchiston, Wayne; Akabane, Kenji; Stewart, Ron

2012-09-01

367

Edge properties of principal fractional quantum Hall states in the cylinder geometry  

NASA Astrophysics Data System (ADS)

We study fractional quantum Hall states in the cylinder geometry with open boundaries. We focus on principal fermionic ?= 1/3 and bosonic ?= 1/2 fractions in the case of hard-core interactions. The gap behavior as a function of the cylinder radius is analyzed. By adding enough orbitals to allow for edge modes, we show that it is possible to measure the Luttinger parameter of the nonchiral liquid formed by the combination of the two counterpropagating edges when we add a small confining potential. Although we measure a Luttinger exponent consistent with the chiral Luttinger theory prediction for the full hard-core interaction, the exponent remains nontrivial in the Tao-Thouless limit as well as for simple truncated states that can be constructed on the cylinder. If the radius of the cylinder is taken to infinity, the problem becomes a Tonks-Girardeau one-dimensional interacting gas in Fermi and Bose cases. Finally, we show that the Tao-Thouless and truncated states have an edge electron propagator, which decays spatially with a Fermi-liquid exponent, even if the energy spectrum can still be described by a nontrivial Luttinger parameter.

Soule, Paul; Jolicoeur, Thierry

2013-03-01

368

Edge properties of principal fractional quantum Hall states in the cylinder geometry  

NASA Astrophysics Data System (ADS)

We study fractional quantum Hall states in the cylinder geometry with open boundaries. We focus on principal fermionic ?=1/3 and bosonic ?=1/2 fractions in the case of hard-core interactions. The gap behavior as a function of the cylinder radius is analyzed. By adding enough orbitals to allow for edge modes, we show that it is possible to measure the Luttinger parameter of the nonchiral liquid formed by the combination of the two counterpropagating edges when we add a small confining potential. Although we measure a Luttinger exponent consistent with the chiral Luttinger theory prediction for the full hard-core interaction, the exponent remains nontrivial in the Tao-Thouless limit as well as for simple truncated states that can be constructed on the cylinder. If the radius of the cylinder is taken to infinity, the problem becomes a Tonks-Girardeau one-dimensional interacting gas in Fermi and Bose cases. Finally, we show that the Tao-Thouless and truncated states have an edge electron propagator, which decays spatially with a Fermi-liquid exponent, even if the energy spectrum can still be described by a nontrivial Luttinger parameter.

Soulé, Paul; Jolicoeur, Thierry

2012-09-01

369

Spin glass behavior in the weberite related structure Dy3-xYxTaO7  

NASA Astrophysics Data System (ADS)

Crystalline structures with tetrahedral arrangement of magnetic cations are susceptible to present non-collinear magnetism. Dy3TaO7 with weberite-type crystal structure has this arrangement and could display non-conventional magnetic coupling. Previous magnetic studies on Dy3TaO7 have characterized this as an antiferromagnetic system with TN of about 3 K. In this work magnetic properties of polycrystalline samples of the Dy3-xYxTaO7, with weberite structure are presented. X-Ray diffraction of our samples are single phase in all range of compositions. Magnetic properties measured from 2 - 300 K shown a typical Curie-Weiss behavior with the Dy^3+ effective magnetic moment about 10.35 ?B. The compositions x=0.66, 0.33, and 0.0 display a maximum in the susceptibility vs. temperature at 2.3, 2.7, and 3 K respectively. This behavior has been previously assigned to an antiferromagnetic transition; however our AC magnetic measurements as a function of frequency indicate a spin glass behavior. Since magnetic cations have tetrahedral arrangement for x=0, a magnetic frustrated state is anticipated for this composition.

Francisco Gomez Garcia, Jose; Tavizon, Gustavo; Duran, Alejandro; Escudero, Roberto

2013-03-01

370

Classification of single particle optical scattering patterns by the spectrum enhancement algorithm  

NASA Astrophysics Data System (ADS)

Airborne material particles in the 5?m size range have been collected, resuspended and analyzed by the TAOS (two-dimensional angular optical scattering) technique. The corresponding patterns of light intensity scattered by single particles have been automatically classified by an algorithm based on "spectrum enhancement", multivariate statistics and supervised optimization. The enhanced spectrum has resulted from some non-linear operations on fractional spatial derivatives of the pattern. It has yielded morphological descriptors of the pattern. A multiobjective optimization algorithm has included principal components analysis and has maximized pairwise discrimination between classes. The classifier has been trained by TAOS patterns from 10?m polystyrene spheres (P) and background aerosol particles (B). Then it has been applied to recognize patterns from airborne debris (A) sampled on a car racing track. Training with at least 10 patterns per class has discriminated P and B from A at confidence levels >=90%. Training by samples of smaller sizes (e.g., 5P and 12B patterns) has obviously yielded lower confidence levels (65% in B-A discrimination).

Crosta, Giovanni F.

2005-11-01

371

The crystal chemistry of L-Ta2O5 and related structures  

NASA Astrophysics Data System (ADS)

Single crystals of a new form of L-Ta2O5 with a 19×b superstructure have been synthesised by flux growth. The phase is most likely stabilised by the incorporation of a small amount of lithium (0.14 wt% Li) from the flux. The phase has C-centred monoclinic symmetry with a=6.1939(4)Å, b=69.549(5)Å (=19×3.66Å), c=3.8895(3)Å, ?=90.00(1)°. The structure was refined in space group C112/m to R1=0.044 for 814 unique reflections with F>4?(F). The structure can be described as comprising chains of edge-shared TaO7 pentagonal bipyramids that are regularly folded at (010) planes to give sinusoidal chains along [010]. These chains are interconnected along [100] and [001] by corner sharing, creating inter-chain regions that are occupied by isolated TaO6 octahedra and pairs of corner-shared octahedra. A comparison with published data for high-quality refinements of related structures has led to the development of a general model that can explain the structural chemistry variations in the known L-Ta2O5-related structures. A shorthand notation is presented for representing the structures, based on the sequence along [010] of the interchain octahedra.

Grey, I. E.; Mumme, W. G.; Roth, R. S.

2005-11-01

372

Enhancement of green-light photoluminescence of Ta2O5 nanoblock stacks.  

PubMed

In this study we have explored the structural, electronic, and photoluminescence (PL) properties of Ta(2)O(5) nanoblock stacks. The Ta(2)O(5) nanoblocks were synthesized by the hot filament metal-oxide vapor deposition (HFMOVD) technique and randomly arranged in large-area stacks. Field-emission scanning electron microscopy (FESEM) showed most of the stacking Ta(2)O(5) nanoblocks to be 21 nm wide. Energy dispersive spectroscopy (EDS) analysis verified the presence of only the elements Ta and O. X-Ray photoemission spectroscopy (XPS) not only revealed the electronic structures and chemical properties of the stacking Ta(2)O(5) nanoblocks but also their stoichiometric Ta/O ratio of ?0.416 (i.e. Ta:O = 2.08?:?5). Photoluminescence (PL) spectroscopy showed very strong green-light emissions, which emerged from the trap-levels of the oxygen vacancies within the Ta(2)O(5) bandgap. The PL intensities were linearly enhanced by increasing the laser power and the excitation time. The PL results suggest that the nanoblocks are excellent visible-light emitters. PMID:21709873

Devan, Rupesh S; Lin, Ching-Ling; Gao, Shun-Yu; Cheng, Chia-Liang; Liou, Yung; Ma, Yuan-Ron

2011-06-27

373

Synthesis, Structure, and Physical Properties for a Series of Trigonal Bipyramidal MII-Cl Complexes with Intramolecular Hydrogen Bonds  

PubMed Central

A series of transition metal chloro complexes with the tetradentate tripodal tris(2-amino-oxazoline) ligand TAO have been synthesized and characterized. X-ray structural analyses of these compounds demonstrate the formation of the mononuclear complexes [MII(TAO)(Cl)]+, where MII = Cr, Mn, Fe, Co, Ni, Cu and Zn. These complexes exhibit distorted trigonal-bipyramidal geometry, coordinating the metal through an apical tertiary amine, three equatorial imino nitrogen atoms, and an axial chloride anion. All the complexes possess an intramolecular hydrogen-bonding (H-bonding) network within the cavity occupied by the metal-bound chloride ion. The metal-chloride bond distances are atypically long, which is attributed to the effects of the H-bonding network. Nuclear magnetic resonance (NMR) spectroscopy of the Zn complex suggests that the solid-state structures are representative of that observed in solution, and that the H-bonding interactions persist as well. Additionally, density functional theory (DFT) calculations were carried out to probe the electronic structures of the complexes.

Sickerman, Nathaniel S.; Park, Young Jun; Ng, Gary K.-Y.; Bates, Jefferson E.; Hilkert, Mark; Ziller, Joseph W.; Furche, Filipp

2013-01-01

374

CORRIGENDUM: Prospects for a new boson W+/-1 in the minimal Higgsless model at the LHC Prospects for a new boson W+/-1 in the minimal Higgsless model at the LHC  

NASA Astrophysics Data System (ADS)

The author list originally given in the above article (Ming-Shui Chen, Jian-Guo Bian, Guo-Ming Chen, Hong-Jian He, Chun-Hua Jiang, Zu-Hao Li, Song Liang, Xiang-Wei Meng, Yong-Hui Qi, Zhi-Cheng Tang, Jun-Quan Tao, Zheng Wang, Jian Wang, Jian Wang, Xian-You Wang, Jian-Xiong Wang, Hong Xiao, Min Yang, Jing-Jing Zang, Bin Zhang, Zhen Zhang and Zhen- Xia Zhang) is incorrect. The correct author list is: Ming-Shui Chen, Jian-Guo Bian, Guo-Ming Chen, Chun-Hua Jiang, Zu-Hao Li, Song Liang, Xiang-Wei Meng, Zhi-Cheng Tang, Jun-Quan Tao, Zheng Wang, Jian Wang, Jian Wang, Xian-You Wang, Jian-Xiong Wang, Hong Xiao, Min Yang, Jing-Jing Zang, Bin Zhang, Zhen Zhang and Zhen-Xia Zhang. Hong-Jian He and Yong-Hui Qi did not take part in the writing of this text and do not bear any responsibility for its contents. Also, reference [4] in the paper should be corrected to: [4] Hong-Jian He et al 2008 Phys. Rev. D 78 031701(R)

Chen, Ming-Shui; Bian, Jian-Guo; Chen, Guo-Ming; He, Hong-Jian; Jiang, Chun-Hua; Li, Zu-Hao; Liang, Song; Meng, Xiang-Wei; Qi, Yong-Hui; Tang, Zhi-Cheng; Tao, Jun-Quan; Wang, Zheng; Wang, Jian; Wang, Jian; Wang, Xian-You; Wang, Jian-Xiong; Xiao, Hong; Yang, Min; Zang, Jing-Jing; Zhang, Bin; Zhang, Zhen; Zhang, Zhen-Xia

2009-12-01

375

Early Observations in the Taiwanese-American Occultation Survey  

NASA Astrophysics Data System (ADS)

The Taiwanese-American Occultation Survey (TAOS) is a program dedicated to performing a survey of the size and number distribution for small bodies (< 10km) in the Kuiper Belt. These objects are too faint to be detected through traditional means, but can be observed via their occultations of background stars. This technique is challenging due to the low event rate, the short event duration (< 200ms), marginal signal to noise of detections, and the possibility of a high false detection rate due to atmospheric fluctuations or other terrestrial phenomena. TAOS overcomes these obstacles with a four robotic telescope array (50cm) located in Lulin, Taiwan. Each telescope is equipped with a 2048 x 2048 pixel CCD camera. All four telescopes synchronously monitor up to 2000 stars autonomously at 5 Hz. We discuss the current state of the survey and the overall performance of the system during predicted asteroid occultations. In particular, we discuss our two telescope response to the occultation by (1723) Klemola of HIP 050535 (V = 8.46), with a maximal duration of 1.3 seconds and 7.2 magnitude drop.

Alcock, C.; Bianco, F.; Lehner, M.; Dave, R.; Giammarco, J.; Schwamb, M.; Cook, K.; Marshall, S.; de Pater, I.; Porrata, R.; Rice, J.; Lissauer, J.; Lee, T.; King, S. K.; Wang, A.; Wang, S. Y.; Wen, C. Y.; Chen, W. P.; Ip, W.; Chang, Y. H.; Kinoshita, D.; Lin, H. C.; Mondal, S.; Zhang, Z. W.; Axelrod, T.; Byun, Y. I.

2005-12-01

376

Chemical Solution-Based Epitaxial Oxide Films on Biaxially Textured Ni-W Substrates with Improved Out-of-Plane Texture for YBCO-Coated Conductors  

NASA Astrophysics Data System (ADS)

Epitaxial films of rare-earth (RE) niobates (where the rare earth includes La, Ce, and Nd) and lanthanum tantalate with pyrochlore structures were grown directly on biaxially textured nickel-3 at.% tungsten (Ni-W) substrates using a chemical solution deposition (CSD) process. Scanning electron microscopy (SEM) and atomic force microscopy (AFM) analysis revealed the surface morphology of the films to be smooth and homogeneous. Detailed X-ray diffraction analysis showed that the films of pyrochlore RE niobate and La-tantalate are highly textured with cube-on-cube epitaxy. The overall texture quality of the films was investigated by measuring the full-width half-maximum (FWHM) of the (004) and (222) rocking curves. We observed a sharper texture for both lanthanum niobate (La3NbO7) and lanthanum tantalate (La3TaO7) films compared to the underlying Ni-W substrate, though they have a larger lattice misfit with the Ni-W substrates. These results were comparable to the texture improvement observed in vacuum-deposited Y2O3 seed layers. Texture improvement in the seed layer is the key towards obtaining YBCO films with a?higher critical current density. Hence, solution-deposited La3NbO7 and La3TaO7 films can be used as a seed layer towards developing all metalorganic-deposited (MOD) buffer/YBCO architectures.

Bhuiyan, M. S.; Paranthaman, M.; Sathyamurthy, S.

2007-10-01

377

Crystal structures and ferroelectric properties of SrBi2Ta2O9 and Sr0.8Bi2.2Ta2O9  

NASA Astrophysics Data System (ADS)

Crystal structures of ferroelectric materials of stoichiometric SrBi2Ta2O9 (TC=300 °C) and Sr-deficient-and-Bi-excess Sr0.8Bi2.2Ta2O9 (TC=400 °C) were refined by neutron powder diffraction. Bi2O2 layer and TaO6 octahedra are considerably distorted and atomic displacements along the a axis cause ferroelectric spontaneous polarization. In Sr0.8Bi2.2Ta2O9, both Bi substitution and cation vacancies at the Sr site were revealed and a chemical composition of (Sr0.82Bi0.12)Bi2Ta2O9.0 was obtained. The calculated polarization of Sr0.8Bi2.2Ta2O9 is larger than that of the stoichiometric sample, which is consistent with observations of remanent polarization in thin-film capacitors. The Bi substitution and the cation vacancies at the Sr site enhance structural distortion in the TaO6 octahedra and lead to the larger ferroelectric spontaneous polarization and the higher Curie temperature.

Shimakawa, Y.; Kubo, Y.; Nakagawa, Y.; Kamiyama, T.; Asano, H.; Izumi, F.

1999-03-01

378

Extent of surgery in clinically evident but operable MTC - when is central and/or lateral lympadenectomy indicated?  

PubMed Central

Medullary thyroid carcinoma (MTC) metastasizes very early lymphogeneously. It has been shown that the presence of lymph node metastases is associated with a worse outcome. Postoperative biochemical cure, i.e. normalization of posttherapeutical calcitonin levels, has been shown to correlate with a better outcome. The rate of biochemical cure decreases dramatically in the presence of lymph node metastases but can still be achieved in about 30-40% of patients despite the presence of lymph node metastases. In 2009, the American Thyroid Association (ATA) published guidelines on the management of MTC. Various recommendations in the guidelines are dealing with the extent of lymph node dissection in different clinical settings. This article summarizes and comments on these recommendations.

2013-01-01

379

An Improved Method for TIMS High Precision Nd Isotopic Analysis of Very Small Aliquots (1- 10ng) With Example Application in Garnet Sm/Nd Geochronology  

NASA Astrophysics Data System (ADS)

Technological and scientific developments have demonstrated both the attainability and the utility of very high precision (i.e. 5-20ppm 2 ?) Nd isotopic measurements with TIMS. However such high precision has been limited to relatively large aliquots of Nd, on the order of several hundred nanograms. Several potential applications of precise Nd isotopic measurements, including garnet Sm/Nd geochronology, do not always permit such large samples, instead yielding only a few nanograms of Nd. We have explored and tested an improved method for Nd isotopic analysis of such small (1-10ng) aliquots of Nd using the NdO+ method with a Triton TIMS at Boston University. Analyzing Nd isotopes as the oxide is a well known technique, frequently involving an oxygen bleed valve. Instead, we forego the bleed valve and load samples with a TaO slurry which provides the oxygen source. Using an in-house Nd isotopic standard solution, 4ng loads easily yield stable 2.0-2.5 volt beams resulting in internal precisions of 10ppm 2 ? RSE. Within barrel external precision of 4ng loads of the Nd standard is 13ppm 2 ? RSD (n=20). Long term (6 months, six analysts) external precision of 4ng loads of the standard is currently 23ppm 2 ? RSD (n=55) suggesting that further improvements are possible. As a further test of this method, we dissolved a natural rock sample (a metapelite), separated the Nd using TRU- spec and MLA column chemistry, and loaded nineteen 4ng loads in one barrel. Within barrel external precision was 21ppm 2 ? RSD (n=18). This precision represents a significant advance over previous NdO+ analyses of small samples using an oxygen bleed valve. The TaO loading method for small Nd aliquots is useful in Sm/Nd garnet geochronology as exemplified by two case studies. Garnets from eclogite facies gneisses from Norway ran very well with 2.4-18ng loads and yielded age precision as good as 0.8 million years 2 ?. Conversely, garnets from blueschist facies rocks from Sifnos, Greece, ran poorly with similarly sized 1-17ng loads and consequently yielded generally poorer age precision. Differences between the two garnet sample suites must relate to the garnets themselves (notably including much lower Nd concentration in Sifnos garnets), not the identical column chemistry nor the TaO loading method. Additional procedures may be required to cleanly separate Nd from samples where Nd concentrations are very low (?1ppm). As always, clean separation and column chemistry represents an unavoidable limiting factor in achieving precise isotopic measurements.

Baxter, E. F.; Harvey, J.; Mehl, L. Y.; Peterman, E. M.

2007-12-01

380

Warm Eddy Structure Observed During EPIC in Eastern Pacific Ocean  

NASA Astrophysics Data System (ADS)

During the NSF/NOAA sponsored Eastern Pacific Investigation of Climate (EPIC) field program in Sept. and Oct. 2001, oceanic current, temperature and salinity profiles were acquired by deploying expendable profilers from research aircraft flights above the warm pool grid centered on the TAO mooring at 10oN 95oW and the R/V Ron Brown, and along the 95oW transect from the NOAA WP-3D and the NCAR WC-130, respectively. Analyses of mooring, ship and aircraft observations suggest the propagation of a wind-forced, warm eddy in accord with remotely sensed fields from radar altimetry and TRMM microwave imager (TMI) measurements. This anti- cyclonically rotating warm eddy, consistent with Rossby wave dynamics, impacted both the oceanic and atmospheric mixed layer structure. To examine the evolving characteristics of this oceanic feature, SSTs, isotherm depths and oceanic heat content variations (relative to the 26oC isotherm depth referred to as OHC) were compared at the TAO buoy. Satellite- based OHC variations were estimated by inferring isotherm depths (20oC, 26oC) from blended and objectively mapped, altimeter-derived surface height anomaly (SHA) fields based on climatology and TMI-derived SSTs. Based on sequential maps of the SHA, the observed warm eddy had SHA elevation of 12 to 14 cm that indicated a propagation speed of 13 cm s-1 towards the southwest. Inferred isotherm depths and OHC variations agreed with those from the TAO mooring and profiler measurements. For example, the 26oC isotherm depth ranged from 35 to 40 m with OHC values of 40 kJ cm-2. Understanding the evolving 3-D structure of these features is central to assessing the upper ocean's role in hurricane intensity fluctuations in the Eastern Pacific Ocean. This approach is now being applied to several years of in situ and remotely sensed measurements in this regime to assess uncertainties in satellite retrievals to build climatology for use with hurricane intensity forecast models as in the Atlantic Ocean basin as part of the NOAA Joint Hurricane Testbed program.

Shay, L. K.; Jaimes, B.; Brewster, J.

2007-05-01

381

Current trends in the management of Graves' disease  

SciTech Connect

Members of the American Thyroid Association were invited to participate in a survey of the management of Graves' disease. One primary case and several variations were provided, which differed in respect to age, sex, goiter size, severity, etc. The questionnaire was based on the format used in a similar survey of members of the European Thyroid Association. The aim of the survey was to determine (1) how expert thyroidologist employ diagnostic procedures for this disorder, and (2) the choice of therapy of the three treatment options and its manner of implementation. Questionnaires were sent only to clinically active members. The overall response rate was 62%. Data analysis was possible on 52% of members surveyed and was performed using SPSS and a specific Fortran program. In the laboratory evaluation of the primary case a radioiodine uptake, scan, serum total T4, and basal TSH were requested by 92%, 47%, 83%, and 66%, respectively, with 84% of respondents using an ultrasensitive TSH assay. For management of the primary case, radioiodine treatment was the first choice of 69% of the respondents. Antithyroid drugs were used briefly (3-7 days) before 131I by 28%, whereas 41% said they would employ thioureas after 131I. Of those using 131I, 66% tailored the dose to achieve euthyroidism as the goal of therapy, while 34% aimed for hypothyroidism requiring T4 replacement. Only 30% of respondents chose thioureas as a first line of treatment (72% propylthiouracil; 28% tapazole). The duration of drug therapy was a predetermined fixed interval for 80% of the respondents, with 90% treating for 1-2 yr. Other specific trends in diagnostic approach and therapeutic preferences were identified for the eight variations on the primary case problem.

Solomon, B.; Glinoer, D.; Lagasse, R.; Wartofsky, L. (Walter Reed Army Medical Center, Washington, DC (USA))

1990-06-01

382

Extending the Newns-Anderson model to allow nanotransport studies through molecules with floppy degrees of freedom  

NASA Astrophysics Data System (ADS)

The Newns-Anderson model is ubiquitous in studies of the molecular transport in the presence of solvent (outer) reorganization. The present work demonstrates that intramolecular reorganization can also be significant for the transport through molecules with floppy degrees of freedom, for which the Newns-Anderson model can be extended. The expressions of the model parameters deduced from electronic structure calculations for (4, 4')-bipyridine (44BPY) quantitatively differ from those characteristic for outer reorganization due to strong intramolecular anharmonicities. These expressions can be utilized as input in transport calculations for 44BPY-based molecular junctions of experimental interest (Xu B. and Tao N. J., Science, 301 (2003) 1221; Pobelov I. V. et al., J. Am. Chem. Soc., 130 (2008) 16045; Widawsky J. R. et al., Nano Lett., 12 (2012) 354).

Bâldea, Ioan

2012-08-01

383

Determinant Quantum Monte Carlo Study of the Enhancement of d-wave Pairing by Charge Inhomogeneity  

NASA Astrophysics Data System (ADS)

Striped phases, in which spin, charge, and pairing correlations vary inhomogeneously in the CuO2 planes, are a known experimental feature of cuprate superconductors, and are also found in a variety of numerical treatments of the two dimensional Hubbard Hamiltonian. In this paper we use determinant Quantum Monte Carlo to show that if a stripe density pattern is imposed on the model, the d-wave pairing vertex is significantly enhanced. We attribute this enhancement to an increase in antiferromagnetic order which is caused by the appearance of more nearly half-filled regions when the doped holes are confined to the stripes. We also observe an enhanced d-wave pair correlation inside stripes reaching its maximum value when the ?-phase shift in the magnetic order takes place. Reference: Rubem Mondaini and Tao Ying and Thereza Paiva and Richard T. Scalettar, Phys. Rev. B 86, 184506 (2012).

Mondaini, Rubem; Ying, Tao; Paiva, Thereza; Scalettar, Richard T.

2013-03-01

384

Spherical agglomeration of superconducting and normal microparticles with and without applied electric field  

NASA Astrophysics Data System (ADS)

It was reported by Tao [Phys. Rev. Lett.PRLTAO0031-900710.1103/PhysRevLett.83.5575 83, 5575 (1999); Physica CPHYCE60921-453410.1016/S0921-4534(01)01287-4 377, 357 (2002); Phys. Rev. BPRBMDO1098-012110.1103/PhysRevB.68.144505 68, 144505 (2003); Physica CPHYCE60921-453410.1016/j.physc.2003.09.069 398, 78 (2003)] that in the presence of a strong electric field superconducting microparticles assemble into balls of macroscopic dimensions. Such a finding has potentially important implications for the understanding of the fundamental physics of superconductors. However, we report here the results of experimental studies showing that (i) ball formation also occurs in the absence of an applied electric field, (ii) the phenomenon also occurs at temperatures above the superconducting transition temperature, and (iii) it can also occur for nonsuperconducting materials. Possible origins of the phenomenon are discussed.

Ghosh, R. S. B.; Hirsch, J. E.

2012-08-01

385

Crystal structures and phase transitions in Sr doped Ba2InTaO6 perovskites  

NASA Astrophysics Data System (ADS)

The crystal structures of the double perovskites of the type Ba2-xSrxInTaO6 have been studied by synchrotron X-ray and neutron powder diffraction methods. The structures are based on ordered array of the tilted InO6 and TaO6 octahedra, with the Ba/Sr cations being completely disordered. The structure evolves from cubic to monoclinic Fm3¯m?x~0.6I4/m?x~1.2I2/m?x~1.6P21/n. The changes in the symmetry induced by replacing the Ba with Sr have been identified by a symmetry-mode analysis. Variable temperature S-XRD studies of selected examples have shown that heating the samples induces the same sequence of transitions observed in the composition dependent studies.

Zhou, Qingdi; Tan, Teck-Yee; Kennedy, Brendan J.; Hester, James R.

2013-10-01

386

RAPID COMMUNICATION: DC superconducting quantum interference devices fabricated using bicrystal grain boundary junctions in Co-doped BaFe2As2 epitaxial films  

NASA Astrophysics Data System (ADS)

DC superconducting quantum interference devices (dc-SQUIDs) were fabricated in Co-doped BaFe2As2 epitaxial films on (La, Sr)(Al, Ta)O3 bicrystal substrates with 30° misorientation angles. The 18 × 8 µm2 SQUID loop with an estimated inductance of 13 pH contained two 3 µm wide grain boundary junctions. The voltage-flux characteristics clearly exhibited periodic modulations with ?V = 1.4 µV at 14 K, while the intrinsic flux noise of dc-SQUIDs was 7.8 × 10 - 5 ?0 Hz - 1/2 above 20 Hz. The rather high flux noise is mainly attributed to the small voltage modulation depth which results from the superconductor-normal-metal-superconductor junction nature of the bicrystal grain boundary.

Katase, Takayoshi; Ishimaru, Yoshihiro; Tsukamoto, Akira; Hiramatsu, Hidenori; Kamiya, Toshio; Tanabe, Keiichi; Hosono, Hideo

2010-08-01

387

Properties of epitaxial Ba(Fe1-xCox)2As2 thin films on different substrates  

NASA Astrophysics Data System (ADS)

We have grown epitaxial, optimally-doped superconducting Ba(Fe0.92Co0.08)2As2 films on SrTiO3, (La, Sr)(Al, Ta)O3 and LaAlO3 substrates, which have a range of lattice mismatch, and studied the strain effect on the structural and transport properties of the films. We found that the superconducting transition temperature increased as the c lattice constant decreased and a lattice constant increased. The thickness dependence of the superconducting transition temperature was studied, which was related to the strain and strain relaxation. A zero-resistance Tc of 21.7 K was obtained in the 120 nm-thick Ba(Fe0.92Co0.08)2As2 film on SrTiO3 substrate.

Lei, Q. Y.; Golalikhani, M.; Rafti, A.; Qiu, J.; Hambe, M.; Williams, F.; Yang, Q.; Temple, D.; Bauer, E. D.; Ronning, F.; Jia, Q. X.; Wang, X. F.; Chen, X. H.; Weiss, J. D.; Hellstrom, E. E.; Xi, X. X.

2013-03-01

388

Complete genome sequence of Nakamurella multipartita type strain (Y-104T)  

SciTech Connect

Nakamurella multipartita (Yoshimi et al. 1996) Tao et al. 2004 is the type species of the small one-species genus Nakamurella in the actinomycetal suborder Frankineae. The nonmotile, coccus-shaped strain was isolated from activated sludge acclimated with sugar-containing synthetic wastewater, and is able of accumulating large amounts of polysaccharides in its cells. Here we describe the features of the organism, together with the complete genome sequence and annotation. This is the first complete genome sequence of a member of the family Nakamurellaceae. The 6,060,298 bp long single replicon genome with its 5415 protein-coding and 53 RNA genes is part of the Genomic Encyclopedia of Bacteria and Archaea project.

Tice, Hope [U.S. Department of Energy, Joint Genome Institute; Mayilraj, Shanmugam [DSMZ - German Collection of Microorganisms and Cell Cultures GmbH, Braunschweig, Germany; Sims, David [Los Alamos National Laboratory (LANL); Lapidus, Alla L. [U.S. Department of Energy, Joint Genome Institute; Nolan, Matt [U.S. Department of Energy, Joint Genome Institute; Lucas, Susan [U.S. Department of Energy, Joint Genome Institute; Glavina Del Rio, Tijana [U.S. Department of Energy, Joint Genome Institute; Copeland, A [U.S. Department of Energy, Joint Genome Institute; Cheng, Jan-Fang [U.S. Department of Energy, Joint Genome Institute; Meincke, Linda [Los Alamos National Laboratory (LANL); Bruce, David [Los Alamos National Laboratory (LANL); Goodwin, Lynne A. [Los Alamos National Laboratory (LANL); Pitluck, Sam [U.S. Department of Energy, Joint Genome Institute; Ivanova, N [U.S. Department of Energy, Joint Genome Institute; Mavromatis, K [U.S. Department of Energy, Joint Genome Institute; Ovchinnikova, Galina [U.S. Department of Energy, Joint Genome Institute; Pati, Amrita [U.S. Department of Energy, Joint Genome Institute; Chen, Amy [U.S. Department of Energy, Joint Genome Institute; Palaniappan, Krishna [U.S. Department of Energy, Joint Genome Institute; Land, Miriam L [ORNL; Hauser, Loren John [ORNL; Chang, Yun-Juan [ORNL; Jeffries, Cynthia [Oak Ridge National Laboratory (ORNL); Detter, J. Chris [U.S. Department of Energy, Joint Genome Institute; Rohde, Manfred [HZI - Helmholtz Centre for Infection Research, Braunschweig, Germany; Goker, Markus [DSMZ - German Collection of Microorganisms and Cell Cultures GmbH, Braunschweig, Germany; Bristow, James [U.S. Department of Energy, Joint Genome Institute; Eisen, Jonathan [U.S. Department of Energy, Joint Genome Institute; Markowitz, Victor [U.S. Department of Energy, Joint Genome Institute; Hugenholtz, Philip [U.S. Department of Energy, Joint Genome Institute; Kyrpides, Nikos C [U.S. Department of Energy, Joint Genome Institute; Klenk, Hans-Peter [DSMZ - German Collection of Microorganisms and Cell Cultures GmbH, Braunschweig, Germany; Chen, Feng [U.S. Department of Energy, Joint Genome Institute

2010-01-01

389

Solar heating and hot water system installed at St. Louis, Missouri. Final report  

SciTech Connect

Information is provided on the solar heating and hot water system installed at the William Tao and Associates, Inc., office building in St. Louis, Missouri. The information consists of description, photos, maintenance and construction problems, final drawing, system requirements and manufacturer's component data. The solar system was designed to provide 50% of the hot water requirements and 45% of the space heating needs for a 900 square foot office space and drafting room. The solar facility has 252 square foot of glass tube concentrator collectors and a 1000 gallon steel storage tank buried below a concrete slab floor. Freeze protection is provided by a propylene glycol/water mixture in the collector loop. The collectors are roof mounted on a variable tilt array which is adjusted seasonally and is connected to the solar thermal storage tank by a tube-in-shell heat exchanger. Incoming city water is preheated through the solar energy thermal storage tank.

Not Available

1980-04-01

390

The role of discursive resources in science talk  

NASA Astrophysics Data System (ADS)

Tao, Oliver, and Venville's paper addresses a debate between two hypotheses of children's development of conceptual understandings of the Earth. The authors aim to investigate whether culture influences students' conceptions of the Earth. However, one questionable assumption shared among conception and conceptual change studies is that researchers can identify children's mental models, through their discourse, to explain their conceptions of scientific phenomena. In this commentary, I challenge this assumption by looking closely at various interview data and examining different dimensions of interview discourse about the Earth. Based on my findings, I suggest that instead of seeing science talk as representations of mental models, we look at children's science talk as discursive practices mediated by the immediate social situation and the broader social milieu.

Hsu, Pei-Ling

2013-06-01

391

Different perspectives of cultural mediation: implications for the research design on studies examining its effect on students' cognition  

NASA Astrophysics Data System (ADS)

In this forum, I extend Tao, Oliver, and Venville's paper Chinese and Australian children's understanding of the earth: a cross cultural study of conceptual development to discuss the different views on culture and cultural mediation. I tease out nuances in the viewpoints to suggest three ways to theoretically frame studies examining cultural mediation of students' cognition. Specifically, cultural mediation may be attributed to innate psychological attributes, an accretion of cultural elements, or the social interaction process. Each of these ideas represents a theoretical lens and has implications for the research design of studies relating cultural mediation to cognition. In the final section of this forum paper, I show how a study conducted from the symbolic interactionist viewpoint underscoring cultural mediation as a social interaction process might unfold.

Teo, Tang Wee

2013-06-01

392

The Protective Effect of Cordymin, a Peptide Purified from the Medicinal Mushroom Cordyceps sinensis, on Diabetic Osteopenia in Alloxan-Induced Diabetic Rats  

PubMed Central

The aim of this study was to investigate the protective effect of cordymin on diabetic osteopenia in alloxan-induced diabetic rats and the possible mechanisms involved. The diabetic rats received daily intraperitoneal injection with cordymin (20, 50, and 100?mg/kg/day) for 5 weeks. Cordymin could restore the circulating blood glucose, glycosylated hemoglobin (HbA1c), serum alkaline phosphatase (ALP), tartrate resistant acid phosphatase (TRAP), and insulin levels in a dose-dependent manner. Also, the treatment of diabetic rats with cordymin could partially reverse the ? cells death and decrease the total antioxidant status (TAOS) in the diabetic rats. The results may directly and indirectly account for the possible mechanism of the beneficial effect of cordymin on diabetic osteopenia, which was confirmed with the increased bone mineral content (BMC) and bone mineral density (BMD) in diabetic rats (P < 0.05). All those findings indicate that cordymin may play a protective role in diabetic osteoporosis.

Qi, Wei; Zhang, Yang; Yan, Ya-bo; Lei, Wei; Wu, Zi-xiang; Liu, Ning; Liu, Shuai; Shi, Lei; Fan, Yong

2013-01-01

393

Thromboangiitis obliterans in two brothers  

PubMed Central

Two brothers (case 1 and case 2) with erythema nodosum were diagnosed with thromboangiitis obliterans (TAO). The patients were treated with compounds including Danshen Dripping Pills, Fufang Danshen Diwan and Salvia tetramethylpyrazine. The patients were also treated with fibro-blast growth factor to promote epidermal growth and Bayaspirin enteric-coated tablets to reduce platelet aggregation. The polysaccharide nucleic acid fraction of Bacillus Calmette-Guérin and compound glycyrrhizin tablets were taken to improve immune function. Following treatment, case 2 had reduced pain levels in the left foot. The ulcer on the first toe of the left foot had decreased in size, with a reduction in pus secretions and inflammation. Case 1 demonstrated a reduction in pus secretion from the ulcer. However, the area of the ulcer had increased, spreading to the fifth toe with gangrene. A tendon had become exposed on the right foot, which was broken and induced severe pain.

LI, QI-LIN; HE, DAN-HUA; HUANG, YONG-HUA; NIU, MU

2013-01-01

394

RETRACTED: The Effect of Coenzyme A Capsule on Serum Triglyceride Concentration inPatients With Hypertriglyceridemia: Results of a Multicenter Clinical Trial.  

PubMed

Retraction notice for "The Effect of Coenzyme A Capsule on Serum Triglyceride Concentration in Patients with Hypertriglyceridemia: Results of a Multicenter Clinical Trial" by Tianming Xuan, Bifeng Wu, Yunpeng Shang, Jiangtao Lai, Xiaosheng Hu, Zhong Liu, and Junzhu Chen The article has been retracted due to its earlier publication in substantially similar form as follows: Effect and Safety of coenzyme A on Hyperlipidemia by Zhao Shu-ping, Chen Ya-qin, Chen Jun-zhu, Lai Jiang-tao, published in the Chinese Journal of New Drugs and Clinical Remedies; 2012:242-245. The Effects of Coenzyme A on Serum Lipids in Patients With Hyperlipidemia: Results of a Multicenter Clinical Trial by Ya-qin Chen, Shui-ping Zhao, Jun-zhu Chen and Jiangtao Lai, published in the Journal of Clinical Endocrinology & Metabolism on January 4, 2013 jc.2012-2702. DOI:10.1210/jc.2012-2702. PMID:23426377

2013-02-19

395

Continuous electrical tuning of the chemical composition of TaO(x)-based memristors.  

PubMed

TaO(x)-based memristors have recently demonstrated both subnanosecond resistance switching speeds and very high write/erase switching endurance. Here we show that the physical state variable that enables these properties is the oxygen concentration in a conduction channel, based on the measurement of the thermal coefficient of resistance of different TaO(x) memristor states and a set of reference Ta-O films of known composition. The continuous electrical tunability of the oxygen concentration in the channel, with a resolution of a few percent, was demonstrated by controlling the write currents with a one transistor-one memristor (1T1M) circuit. This study demonstrates that solid-state chemical kinetics is important for the determination of the electrical characteristics of this relatively new class of device. PMID:22324891

Miao, Feng; Yi, Wei; Goldfarb, Ilan; Yang, J Joshua; Zhang, Min-Xian; Pickett, Matthew D; Strachan, John Paul; Medeiros-Ribeiro, Gilberto; Williams, R Stanley

2012-02-16

396

Anatomy of a Nanoscale Conduction Channel Reveals the Mechanism of a High-Performance Memristor  

NASA Astrophysics Data System (ADS)

Two major challenges for resistance memory devices (memristors) based on conductivity changes in oxide materials are better performance and understanding of the microscopic picture of the switching. After researchers' relentless pursuit for years, tantalum oxide-based memristors have rapidly risen to be the top candidate, showing fast speed, high endurance and excellent scalability. While the microscopic picture of these devices remains obscure, by employing a precise method for locating and directly visualizing the conduction channel, here we observed a nanoscale channel consisting of an amorphous Ta(O) solid solution surrounded by crystalline Ta2O5. Structural and chemical analyses of the channel combined with temperature dependent transport measurements revealed a unique resistance switching mechanism: the modulation of the channel elemental composition, and thus the conductivity, by the cooperative influence of drift, diffusion and thermophoresis, which seem to enable the high switching performance observed. (Miao*, Strachan*, Yang* et al., Advanced Materials. DOI: 10.1002/adma201103379 (2011))

Miao, Feng; Strachan, John Paul; Yang, J. Joshua; Yi, Wei; Goldfarb, Ilan; Zhang, M.-X.; Torrezan, Antonio C.; Eschbach, Peter; Kelley, Ronald D.; Medeiros-Ribeiro, Gilberto; Williams, R. Stanley

2012-02-01

397

Influence of Several Parameters on Frost Growth in Low Temperature Environments  

NASA Astrophysics Data System (ADS)

In order to increase the coefficient of performance of heat exchangers under frosting conditions such as in air conditioners, showcases, and unit coolers, it is necessary to elucidate the frost deposition mechanism in low temperature environments. Frost properties were measured at air temperature below 0°C. The experimental results were analyzed and a simulation model of frost growth in low temperature environments was developed. In the simulation model, frost growth during the crystal growth period was calculated by using the ice column model of Tao et al. and during the subsequent frost growth period, another model was used; the frost growth was calculated according to diffusion into the frost layer on the basis of Fick's law and the model of Le Gall et al. The simulations were performed to calculate the frost growth on a flat plate and the influences of several parameters on frosting phenomenon were elucidated at air temperature of about 0°C.

Yamashita, Koji; Ohkubo, Hidetoshi

398

[Exploration of Nursing Art and Aesthetic Experiences: Cross-disciplinary Links and Dialogues].  

PubMed

Interdisciplinary understanding is crucial for readers today. This article integrates the ideas of four care-aesthetics-column writers in order to illustrate and discuss nursing art and aesthetic care experiences in a cross-disciplinary conversation. This article reflects critically on the art, culture, and nature of nursing in the five themes of: 1) the shape of nursing knowledge, "science" or "art"?; 2) the caring arts: passively regulative or consciously creative labor?; 3) busy hospital workers: a landscape of persons and objects or the creators of the scenery?; 4) nursing skills, arts, and the Tao; and 5) art liberation: is the nursing profession in need of a revolution or fundamental reform? This article utilizes diverse and occasionally contradictory points of view together with practical examples in order to encourage readers to interlink their disparate professional nursing skills and draw aesthetic knowledge from multiple sources and experiences. PMID:23922088

Sheu, Shuh-Jen

2013-08-01

399

Surface Mixed Layer Temperature Variability on Seasonal Time Scales in the Eastern Tropical Pacific  

NASA Astrophysics Data System (ADS)

The eastern tropical Pacific is characterized by a pronounced seasonal cycle and significant hemispheric asymmetries in oceanographic and meteorological conditions. The processes that create these conditions, which influence the regional climate of the eastern Pacific and western North and South America, are poorly known. As part of the Eastern Pacific Investigation of Climate Processes (EPIC), the Tropical Atmosphere Ocean (TAO) moored buoy array along 95W was enhanced in 2000-2003 with additional moorings between 8S- 12N and additional upper ocean and surface meteorological sensors. Data from this enhanced array of measurements are used to characterize variability in the upper ocean and at the air-sea interface, and to diagnose the mixed layer heat balance on seasonal time scales. Results highlight the wide range of processes involved in generating observed sea surface temperature variability, and the importance of both accurate surface flux estimates and sustained measurements of mixed layer properties in the tropics.

McPhaden, M. J.; Cronin, M. F.; McClurg, D. C.

2006-12-01

400

High-pressure phase transformations, pressure-induced amorphization, and polyamorphic transition of the clathrate Rb6.15Si46  

NASA Astrophysics Data System (ADS)

The type-I clathrate Rb6.15Si46 with partly empty cage sites has been studied up to 36 GPa using Raman spectroscopy, synchrotron x-ray diffraction in diamond-anvil cells, and ab initio total-energy and lattice-dynamics calculations. A first phase transition is observed at 13±1GPa and a “volume collapse” transition within the clathrate structure is then observed at 24±1GPa . Pressure-induced amorphization into a high-density amorphous (HDA) state occurs above P=33±1GPa . The HDA form transforms into a low-density amorphous polymorph during decompression. During the compression study using angle dispersive synchrotron x-ray diffraction techniques we measured bulk modulus parameters for rocksalt-structured TaO, included adventitiously in the clathrate sample [ K0=293(3)GPa and K0'=5.4(3) ].

Machon, D.; Toulemonde, P.; McMillan, P. F.; Amboage, M.; Muñoz, A.; Rodríguez-Hernández, P.; San Miguel, A.

2009-05-01

401

Displacement cascades in diatomic materials  

SciTech Connect

A new function, the specified-projectile displacement function p/sub ijk/ (E), is introduced to describe displacement cascades in polyatomic materials. This function describes the specific collision events that produce displacements and hence adds new information not previously available. Calculations of p/sub ijk/ (E) for MgO, Al/sub 2/O/sub 3/ and TaO are presented and discussed. Results show that the parameters that have the largest effect on displacement collision events are the PKA energy and the mass ratio of the atom types in the material. It is further shown that the microscopic nature of the displacement events changes over the entire recoil energy range relevant to fusion neutron spectra and that these changes are different in materials whose mass ratio is near one than in those where it is far from one.

Parkin, D.M.; Coulter, C.A.

1981-01-01

402

Government and industry meet to discuss environmental stewardship and economic development  

SciTech Connect

At the New Mexico Conference on the Environment, government and industry representatives met to address environmental stewardship and economic development, particularly as these issues relate to New Mexico. The session took place March 13, 1996, from 1:30 PM to 5:00 PM, in the Cochiti/Taos room at the Albuquerque Convection Center. The first part of the session dealt with environmental stewardship. The second session discussed economic development. This paper chronicles the highlights of this unique session. It attempts to capture the essence of each speaker; therefore, rather than a strict narrative, this paper consists of a series of quotes that, when seen as a whole, provide an understanding of how government and industry view environmental stewardship and economic development. Moreover, these quotes reveal that these organizations continue to develop effective methodologies to collaborate.

Ramos, O. Jr.

1996-05-01

403

[Effects of environmental factors on Phyllotreta striolata dispersion].  

PubMed

Using marking recapture method, this paper studied the effects of host plants and climatic factors on the dispersion of Phyllotreta striolata adults. The results showed that the dispersion of the beetle was impelled by environment elements (tao = 1 ). Temperature and wind speed had significantly positive correlations with the dispersion of the beetle (P < 0.05), while high temperature had a negative correlation. Wind orientation had a significant effect on the dispersion of the beetle, with the adults mostly flying against or vertically to the wind. Humidity contributed little to the dispersion (P >0.05). Host plant was one of the important factors affecting the dispersion of the beetle. Among the plants studied, flowering Chinese cabbage ranked first in capturing marked adults, followed by mustard and Chinese cabbage, while nearly no marked adults were captured on Chinese kale. PMID:16180758

Gao, Zezheng; Wu, Weijian; Cui, Zhixin; Liang, Guangwen

2005-06-01

404

Calculations of thermoviscoplastic asymmetric deformation of shells of revolution with thickness varying in two directions  

SciTech Connect

The asymmetric elastoplastic stress-strain state (SSS) of shells of revolution with rigidity varying in two directions was studied by Berlyand, using the theory of small elastoplastic strains. He used a system of resolvents, which were obtained on the basis of a combination of the method of integral relations and the method of variable elasticity parameters. In a solution of this problem was obtained with allowance for the loading history. Takezano and Tao, considered the determination of the viscoplastic state of shells of revolution with a constant thickness under asymmetric of shells of revolution with a complex meridional section and a thickness that varies in two directions in considered by using the relations of the theory of deformation along low-curvature trajectories. The physical equations will be linearized by the method of additional strains, which makes it possible to obtain a system of resolvents with an SSS-independent operator.

Merzlyakov, V.A.

1995-08-01

405

A preconcentration procedure for the determination of cadmium in biological material after on-line cloud point extraction.  

PubMed

In this paper, a method involving on-line preconcentration with cloud point extraction for the determination of cadmium in biological samples is presented. The procedure is based on the sorption of micelles containing Cd(II) ions and the reagent 4-(5'-bromo-2'-thiazolylazo)orcinol (Br-TAO) in a minicolumn packed with polyester. The surfactant Triton X-114 was used in the formation of micelles. After sorption, the Cd(II) ions were desorbed from the minicolumn with acid eluent and determined by flame atomic absorption spectrometry. Parameters influencing the cloud point extraction were studied. The method showed a detection limit of 0.5 ?g l(-1) and an enhancement factor of 27. The accuracy was tested by determination of cadmium in certified reference materials (spinach leaves 1570a and tomato leaves 1573a) from the National Institute of Standards and Technology. PMID:21826421

Baliza, Patrícia Xavier; Cardoso, Luiz Augusto Martins; Lemos, Valfredo Azevedo

2011-08-09

406

Stacking faults and their effects on ferroelectric properties in strontium bismuth tantalate  

NASA Astrophysics Data System (ADS)

The stacking faults and their effects on ferroelectric properties in strontium-bismuth-tantalate SrBi2Ta2O9 have been studied by transmission electron microscopy (TEM) and ferroelectric hysteresis loop measurement. The structure of SrBi2Ta2O9 consists of Bi2O2 layers and double perovskite type TaO6 octahedral units. There are four possible types of nonstiochiometric stacking faults: two intrinsic faults by removing either one or two perovskite layers and two extrinsic faults by inserting either one or two perovskite layers. TEM investigation reveals that the stacking faults are the extrinsic type. The extrinsic stacking faults in high density might destroy the ferroelectricity, and the reasons are discussed. With excess Bi, the density can be held low efficiently, and with deficient Sr the stacking faults change its form.

Ding, Y.; Liu, J. S.; Zhu, J. S.; Wang, Y. N.

2002-02-01

407

Transition voltage spectroscopy reveals significant solvent effects on molecular transport and settles an important issue in bipyridine-based junctions  

NASA Astrophysics Data System (ADS)

Results of a seminal study (B. Xu and N. J. Tao, Science, 2003, 301, 1221) on the single-molecule junctions based on bipyridine placed in a solvent have been challenged recently (S. Y. Quek et al., Nat. Nano, 2009, 4, 230) by implicitly assuming a negligible solvent impact on the molecular transport and by merely considering low bias conductance data. In this paper we demonstrate that solvent effects on the molecular transport are important, and to show this we focus our attention on the energy offset ?0 of the dominant molecular orbital (LUMO) relative to the electrode Fermi level. To estimate the energy offset ?sol0 from the full I-V curves presented by Xu and Tao for wet junctions, we resort to the recently proposed transition voltage spectroscopy (TVS). TVS, which plays a key role in the present analysis, emphasizes that data beyond the ohmic conductance regime are needed to reveal the solvent impact. We show that ?sol0 significantly differs from the energy offset ?00 deduced for dry junctions (J. R. Widawsky et al., Nano Lett., 2012, 12, 354). The present work demonstrates that solvent effects on molecular transport are important and can be understood quantitatively. Results of ab initio calculations with and without solvent are reported that excellently explain the difference ??0 = ?sol0 - ?00. ??0 = ??G + ?? + ?W can be disentangled in contributions with a clear physical content: solvation energies (??G), image charges (??), and work functions (?W). Accurate analytical formulae for ??G and ?? are reported, which provide experimentalists with a convenient framework to quantify solvent effects obviating demanding numerical efforts.Results of a seminal study (B. Xu and N. J. Tao, Science, 2003, 301, 1221) on the single-molecule junctions based on bipyridine placed in a solvent have been challenged recently (S. Y. Quek et al., Nat. Nano, 2009, 4, 230) by implicitly assuming a negligible solvent impact on the molecular transport and by merely considering low bias conductance data. In this paper we demonstrate that solvent effects on the molecular transport are important, and to show this we focus our attention on the energy offset ?0 of the dominant molecular orbital (LUMO) relative to the electrode Fermi level. To estimate the energy offset ?sol0 from the full I-V curves presented by Xu and Tao for wet junctions, we resort to the recently proposed transition voltage spectroscopy (TVS). TVS, which plays a key role in the present analysis, emphasizes that data beyond the ohmic conductance regime are needed to reveal the solvent impact. We show that ?sol0 significantly differs from the energy offset ?00 deduced for dry junctions (J. R. Widawsky et al., Nano Lett., 2012, 12, 354). The present work demonstrates that solvent effects on molecular transport are important and can be understood quantitatively. Results of ab initio calculations with and without solvent are reported that excellently explain the difference ??0 = ?sol0 - ?00. ??0 = ??G + ?? + ?W can be disentangled in contributions with a clear physical content: solvation energies (??G), image charges (??), and work functions (?W). Accurate analytical formulae for ??G and ?? are reported, which provide experimentalists with a convenient framework to quantify solvent effects obviating demanding numerical efforts. Electronic supplementary information (ESI) available. See DOI: 10.1039/c3nr51290h

Bâldea, Ioan

2013-09-01

408

Oceanic and atmospheric anomalies of tropical instability waves  

NASA Astrophysics Data System (ADS)

Tropical instability waves (TIWs) are detected in remotely-sensed sea surface height (SSH), temperature (SST), and wind records of the eastern equatorial Pacific. Analyses of TIW anomaly relationships reveal strong dynamical influence of TIWs within approximately 5° of the equator. The first influence is advective heat flux. The primary forcing of TIW SST anomalies is advection of the meridional temperature gradient by TIW currents. The second influence is modification of the wind stress and Ekman pumping fields by TIW surface ocean currents. By affecting surface stress and hence roughness, TIW currents in this low-wind region introduce a significant bias in scatterometer vector wind measurement. This bias is evident in both NSCAT and QuikSCAT winds. The difference between wind measurements from TAO moorings and scatterometers is phase-locked with TIW SST oscillations. These results have important implications for scatterometry and for understanding tropical dynamics, thermodynamics and biogeochemistry.

Polito, Paulo S.; Ryan, John P.; Liu, W. Timothy; Chavez, Francisco P.

409

First derivative of the hard-sphere radial distribution function at contact.  

PubMed

Molecular dynamics simulations have been carried out of the radial distribution function of the hard sphere fluid for a range of densities in the equilibrium fluid and just into the metastable region. The first derivative of the hard-sphere radial distribution function at contact was computed and its density dependence fitted to a simple analytic form. Comparisons were made with semi-empirical formulae from the literature, and of these the formula proposed by Tao et al (1992 Phys. Rev. A 46 8007) was found to be in best agreement with the simulation data, although it slightly underestimates the derivative at the higher packing fractions in excess of about 0.45. Close to contact, within a few per cent of the particle diameter, the radial distribution function can be represented well by a second order polynomial. An exponential function, which has some useful analytic features, can also be applied in this region. PMID:21690868

Heyes, David M; Cass, Michael; Bra?ka, Arkadiusz C; Okumura, Hisashi

2006-07-25

410

Response of a coupled ocean-ice-atmosphere model to data assimilation in the tropical zone of the Pacific Ocean  

NASA Astrophysics Data System (ADS)

This paper deals with numerical experiments based on the coupled ECHAM-HOPE model. The results of experiments are analyzed. The initial fields for the calculations over time periods from one month to one year are constructed based on the results of the data assimilation of temperature profiles from TOGA-TAO moorings. The perturbations of the initial fields and the propagation of these perturbations with specific computational time intervals are analyzed on the basis of the results of these experiments. It is shown that the strongest impacts of the perturbations are localized in specific regions of the World Ocean corresponding to the energetically active zones of the Earth. The mechanism of the transition of these perturbations is also studied. Different statistical properties of the ensemble of experiments are presented.

Belyaev, K. P.; Tuchkova, N. P.; Cubash, U.

2010-06-01

411

Harnessing the meta-generalized gradient approximation for time-dependent density functional theory  

NASA Astrophysics Data System (ADS)

Density functionals within the meta-generalized gradient approximation (MGGA) are widely used for ground-state electronic structure calculations. However, the gauge variance of the kinetic energy density ? confounds applications of MGGAs to time-dependent systems, excited states, magnetic properties, and states with strong spin-orbit coupling. Becke and Tao used the paramagnetic current density to construct a gauge invariant generalized kinetic energy density ??. We show that ?W<=??, where ?W is the von Weizsäcker kinetic energy density of a one-electron system. Thus, replacing ? by ?? leads to current-dependent MGGAs (cMGGAs) that are not only gauge invariant but also restore the accuracy of MGGAs in iso-orbital regions for time-dependent and current-carrying states. The current dependence of cMGGAs produces a vector exchange-correlation (XC) potential in the time-dependent adiabatic Kohn-Sham (KS) equations. While MGGA response properties of current-free ground states become manifestly gauge-variant to second order, linear response properties are affected by a new XC kernel appearing in the cMGGA magnetic orbital rotation Hessian. This kernel reflects the first-order coupling of KS orbitals due to changes in the paramagnetic current density and has apparently been ignored in previous MGGA response implementations. Inclusion of the current dependence increases total computation times by less than 50%. Benchmark applications to 109 adiabatic excitation energies using the Tao-Perdew-Staroverov-Scuseria (TPSS) MGGA and its hybrid version TPSSh show that cMGGA excitation energies are slightly lower than the MGGA ones on average, but exhibit fewer outliers. Similarly, the optical rotations of 13 small organic molecules show a small but systematic improvement upon inclusion of the magnetic XC kernel. We conclude that cMGGAs should replace MGGAs in all applications involving time-dependent or current-carrying states.

Bates, Jefferson E.; Furche, Filipp

2012-10-01

412

Role of Tob55 on mitochondrial protein biogenesis in Trypanosoma brucei  

PubMed Central

Mitochondrial outer membrane (MOM) proteins in parasitic protozoa like Trypanosoma brucei are poorly characterized. In fungi and higher eukaryotes, Tob55 is responsible for the assembly of ?-barrel proteins in the MOM. Here we show that T. brucei Tob55 (TbTob55) has considerable similarity in its primary and secondary structure to Tob55 from other species. TbTob55 is localized in T. brucei MOM and is essential for procyclic cell survival. Induction of Tob55 RNAi decreased the level of the voltage-dependent anion channel (VDAC) within 48 h. Although the primary effect is on VDAC, induction of TbTob55 RNAi for a longer time period also decreased the levels of other nucleus encoded mitochondrial proteins. In addition, the mitochondrial membrane potential was reduced at this later time point possibly due to a reduction in the level of the proteins involved in oxidative phosphorylation. However, mitochondrial structure was not altered due to depletion of Tob55. In vitro protein import of VDAC into mitochondria with a 50-60% reduction of TbTob55 was reduced about 40% in comparison to uninduced control. In addition, the import of presequence-containing proteins such as, cytochrome oxidase subunit 4 (COIV) and trypanosome alternative oxidase (TAO) was affected by about 20 % under this condition. Depletion of VDAC levels by RNAi did not affect the import of either COIV or TAO. Furthermore, TbTob55 over expression increased the steady state level of VDAC as well as the level of the assembled protein complex of VDAC, suggesting that similar to other eukaryotes TbTob55 is involved in assembly of MOM ?-barrel proteins and plays an indirect role in the biogenesis of mitochondrial preproteins destined for the mitochondrial inner membrane.

Sharma, Shvetank; Singha, Ujjal K; Chaudhuri, Minu

2010-01-01

413

Transition voltage spectroscopy reveals significant solvent effects on molecular transport and settles an important issue in bipyridine-based junctions.  

PubMed

Results of a seminal study (B. Xu and N. J. Tao, Science, 2003, 301, 1221) on the single-molecule junctions based on bipyridine placed in a solvent have been challenged recently (S. Y. Quek et al., Nat. Nano, 2009, 4, 230) by implicitly assuming a negligible solvent impact on the molecular transport and by merely considering low bias conductance data. In this paper we demonstrate that solvent effects on the molecular transport are important, and to show this we focus our attention on the energy offset ?0 of the dominant molecular orbital (LUMO) relative to the electrode Fermi level. To estimate the energy offset ? from the full I-V curves presented by Xu and Tao for wet junctions, we resort to the recently proposed transition voltage spectroscopy (TVS). TVS, which plays a key role in the present analysis, emphasizes that data beyond the ohmic conductance regime are needed to reveal the solvent impact. We show that ? significantly differs from the energy offset ? deduced for dry junctions (J. R. Widawsky et al., Nano Lett., 2012, 12, 354). The present work demonstrates that solvent effects on molecular transport are important and can be understood quantitatively. Results of ab initio calculations with and without solvent are reported that excellently explain the difference ??0 = ?-?. ??0 = ??G + ?? + ?W can be disentangled in contributions with a clear physical content: solvation energies (??G), image charges (??), and work functions (?W). Accurate analytical formulae for ??G and ?? are reported, which provide experimentalists with a convenient framework to quantify solvent effects obviating demanding numerical efforts. PMID:23933675

Bâldea, Ioan

2013-08-12

414

An approach to control of band gap energy and photoluminescence upon band gap excitation in Pr(3+)-doped perovskites La(1/3)MO3 (M=Nb, Ta):Pr3+.  

PubMed

We synthesized polycrystalline pristine and Pr(3+)-doped perovskites La(1/3)MO(3) (M = Nb, Ta):Pr(3+) and investigated their crystal structure, optical absorption, and luminescence properties. The optical band gap of La(1/3)NbO(3) (3.2 eV) is smaller than that of La(1/3)TaO(3) (3.9 eV), which is primarily due to the difference in electronegativity between Nb and Ta. In La(1/3)NbO(3):Pr(3+), the red emission assigned to the f-f transition of Pr(3+) from the excited (1)D(2) level to the ground (3)H(4) state upon band gap photoexcitation (near-UV) was observed, whereas the f-f transition of Pr(3+) with blue-green emission from the excited (3)P(0) level to the ground (3)H(4) state was quenched. On the other hand, in La(1/3)TaO(3):Pr(3+), the blue-green emission upon band gap photoexcitation was observed. Their differences in emission behavior are attributed to the energy level of the ground and excited states of 4f(2) for Pr(3+), relative to the energy levels of the conduction and valence bands, and the trapped electron state, which mediates the relaxation of electron from the conduction band to the excited state of Pr(3+). La(1/3)NbO(3):Pr(3+) is a candidate red phosphor utilizing near-UV LED chips (e.g., ? = 375 nm) as an excitation source. PMID:21604725

Inaguma, Yoshiyuki; Muronoi, Tsunehiro; Sano, Keiko; Tsuchiya, Takeshi; Mori, Yuki; Katsumata, Tetsuhiro; Mori, Daisuke

2011-05-23

415

Building a bioinformatics ontology using OIL.  

PubMed

This paper describes the initial stages of building an ontology of bioinformatics and molecular biology. The conceptualization is encoded using the ontology inference layer (OIL), a knowledge representation language that combines the modeling style of frame-based systems with the expressiveness and reasoning power of description logics (DLs). This paper is the second of a pair in this special issue. The first described the core of the OIL language and the need to use ontologies to deliver semantic bioinformatics resources. In this paper, the early stages of building an ontology component of a bioinformatics resource querying application are described. This ontology (TaO) holds the information about molecular biology represented in bioinformatics resources and the bioinformatics tasks performed over these resources. It, therefore, represents the metadata of the resources the application can query. It also manages the terminologies used in constructing the query plans used to retrieve instances from those external resources. The methodology used in this task capitalizes upon features of OIL-The conceptualization afforded by the frame-based view of OIL's syntax; the expressive power and reasoning of the logical formalism; and the ability to encode both handcrafted, hierarchies of concepts, as well as defining concepts in terms of their properties, which can then be used to establish a classification and infer relationships not encoded by the ontologist. This ability forms the basis of the methodology described here: For each portion of the TaO, a basic framework of concepts is asserted by the ontologist. Then, the properties of these concepts are defined by the ontologist and the logic's reasoning power used to reclassify and infer further relationships. This cycle of elaboration and refinement is iterated on each portion of the ontology until a satisfactory ontology has been created. PMID:12075668

Stevens, Robert; Goble, Carole; Horrocks, Ian; Bechhofer, Sean

2002-06-01

416

Total thyroidectomy for benign thyroid disorders in an endemic region.  

PubMed

Total thyroidectomy is increasingly being accepted as a treatment of choice for differentiated thyroid cancer. However, because of presumed increased morbidity associated with this procedure, it is still not considered a viable option for management of benign thyroid disorders. To assess the safety and efficacy of total thyroidectomy for management of benign thyroid disorders, we analyzed our data from 127 total thyroidectomies performed for benign thyroid disorders. Demographic details, biochemical findings, indications for operation, specimen weight, and complications were noted. Among these patients, 52 had a toxic goiter and 75 had a nontoxic goiter. The mean duration of the goiters being present was 6.08 +/- 6.06 years (0.9--26.0 years), and the mean weight of the specimens was 136.88 +/- 120.68 g. The incidence of occult malignancy was 6.3% (n = 8), and those of permanent hypothyroidism and permanent recurrent laryngeal nerve palsy were 1.6% and 0.8%, respectively. Total thyroidectomy should be considered a treatment of choice for multinodular goiter and Graves' disease in a setting of palpable nodule(s) or ophthalmopathy (or both). It is particularly relevant in endemic regions where patients present with a long-standing, large nodular goiter with virtually no normal thyroid tissue. Reoperation for recurrent goiter in such a setting would be fraught with distressing complications. PMID:11343181

Mishra, A; Agarwal, A; Agarwal, G; Mishra, S K

2001-03-01

417

Association between HLA-B*46 Allele and Graves Disease in Asian Populations: A Meta-Analysis  

PubMed Central

Graves' disease (GD) is a leading cause of hyperthyroidism, which affects 1.0-1.6% of the general population. Previous studies reported a higher GD prevalence in Asian populations compared to Caucasian populations. The etiology of GD involves complex interactions between predisposing genes and environmental triggers. Genetic studies have shown that the human leukocyte antigen (HLA) is an important candidate genetic region associated with GD in Asian populations. However, the results were inconsistent and inconclusive. Here, we performed a meta-analysis to evaluate the role of the HLA-B*46 allele in GD in Asian populations. A total of 14 case-controlled studies on the association of the HLA-B*46 allele in 1743 GD patients and 5689 controls were included. Our results showed a trend toward an increased risk of GD in HLA-B*46-positive subjects compared to those HLA-B*46-negative (OR = 2.48; 95% CI = 1.96-3.13, P < 0.01). However, there were some limitations to the current meta-analysis, such as heterogeneity (Pheterogeneity < 0.01 and I2 = 68.0%) or the different typing methods (serological and genotyping methods). The meta-analysis indicated that the HLA-B*46 allele is a risk factor for GD in Asian populations. Future studies on the role of the HLA-B*46 allele in GD should consider complications such as periodic paralysis, ophthalmopathy and recurrence.

Li, Yiping; Yao, Yufeng; Yang, Man; Shi, Li; Li, Xianli; Yang, Ying; Zhang, Ying; Xiao, Chunjie

2013-01-01

418

Mutation in collagen II alpha 1 isoforms delineates Stickler and Wagner syndrome phenotypes  

PubMed Central

Purpose Stickler syndrome is an arthro-ophthalmopathy with phenotypic overlap with Wagner syndrome. The common Stickler syndrome type I is inherited as an autosomal dominant trait, with causal mutations in collagen type II alpha 1 (COL2A1). Wagner syndrome is associated with mutations in versican (VCAN), which encodes for a chondroitin sulfate proteoglycan. A three-generation Caucasian family variably diagnosed with either syndrome was screened for sequence variants in the COL2A1 and VCAN genes. Methods Genomic DNA samples derived from saliva were collected from all family members (six affected and four unaffected individuals). Complete sequencing of COL2A1 and VCAN was performed on two affected individuals. Direct sequencing of remaining family members was conducted if the discovered variants followed segregation. Results A base-pair substitution (c.258C>A) in exon 2 of COL2A1 cosegregated with familial disease status. This known mutation occurs in a highly conserved site that causes a premature stop codon (p.C86X). The mutation was not seen in 1,142 ethnically matched control DNA samples. Conclusions Premature stop codons in COL2A1 exon 2 lead to a Stickler syndrome type I ocular-only phenotype with few or no systemic manifestations. Mutation screening of COL2A1 exon 2 in families with autosomal dominant vitreoretinopathy is important for accurate clinical diagnosis.

Tran-Viet, Khanh-Nhat; Soler, Vincent; Quiette, Valencia; Powell, Caldwell; Yanovitch, Tammy; Metlapally, Ravikanth; Luo, Xiaoyan; Katsanis, Nicholas; Nading, Erica

2013-01-01

419

Comparison of computed tomographic and cytopathological findings in the evaluation of adult orbital mass.  

PubMed

An observational study was conducted to demonstrate the role of Computed Tomographic (CT) scan to detect clinically suspected adult orbital mass in 47 patients which could not be differentiated clinically. The CT findings were compared and correlated with the findings of fine needle aspiration cytology (FNAC) or histopathology. CT diagnosis of optic nerve sheath meningioma were 12 cases, among them only nine cases confirmed cytopathologically as meningioma and rest three as lymphoma. Among ten cases of hemangioma, eight cases were confirmed cytopathologically as cavernous hemangioma and rest two were pseudotumor and chronic inflammatory lesion. Seven cases diagnosed as pseudotumor in CT were confirmed cytopathologically. Seven cases diagnosed as paranasal sinus masses with orbital extension (nasopharyngeal angiofibroma) in CT were confirmed cytopathologically. Among three cases of thyroid ophthalmopathy diagnosed in CT, only two cases confirmed cytopathologically and rest one cytopathologic diagnosis was not possible due to inadequate tissue supply during FNAC. Two cases of chronic inflammatory lesion diagnosed in CT, also confirmed cytopathologically. Two cases of metastatic lesion diagnosed in CT, also confirmed cytopathologically. Two cases of lacrimal gland tumor diagnosed in CT, also confirmed cytopathologically i.e., pleomorphic adenoma. Two cases of melanoma diagnosed in CT, only one confirmed cytopathologically and rest one cytopathologic diagnosis was not possible due to frank blood came out during FNAC. Pseudotumors were subsequently diagnosed the non-diagnostic cases on the basis of clinical and radiological findings. It is evident from these findings that CT is a useful modality in the diagnosis of adult orbital masses. PMID:23416813

Islam, M N; Amin, M S; Dipi, R M; Khan, N A

2013-01-01

420

COL9A2 and COL9A3 mutations in canine autosomal recessive Oculo-skeletal Dysplasia  

PubMed Central

Oculo-skeletal dysplasia segregates in two canine breeds, the Labrador retriever and samoyed, in which the causative loci have been termed drd1 and drd2, respectively. Affected dogs exhibit short-limbed dwarfism together with severe ocular defects, and this phenotype is inherited as an autosomal recessive trait in both breeds. The clinical and pathological appearance resembles human hereditary arthro-ophthalmopathies such as Stickler syndrome, or Marshall Syndrome, although these human disorders are usually dominant. Linkage studies in drd1-informative pedigrees mapped the locus to canine chromosome 24, and led to the identification of an insertional mutation in exon 1 of the gene COL9A3 that cosegregates with the disease. The drd2 locus was similarly mapped to canine chromosome 15 and shown to cosegregate with a 1,267 bp deletion mutation in the 5? end of COL9A2. Both mutations affect the COL3 domain of the respective gene. Northern analysis showed reduced RNA expression in affected retina compared to normal. These models offer potential for studies such as protein-protein interactions between different members of the collagen gene family; regulation and expression of these genes in retina and cartilage, and even opportunities for gene therapy.

Goldstein, Orly; Guyon, Richard; Kukekova, Anna; Pearce-Kelling, Sue; Johnson, Jennifer; Aguirre, Gustavo D.; Acland, Gregory M.

2010-01-01

421

Thyroid abnormalities after therapeutic external radiation  

SciTech Connect

The thyroid gland is the largest pure endocrine gland in the body and one of the organs most likely to produce clinically significant abnormalities after therapeutic external radiation. Radiation doses to the thyroid that exceed approximately 26 Gy frequently produce hypothyroidism, which may be clinically overt or subclinical, as manifested by increased serum thyrotropin and normal serum-free thyroxine concentrations. Pituitary or hypothalamic hypothyroidism may arise when the pituitary region receives doses exceeding 50 Gy with conventional, 1.8-2 Gy fractionation. Direct irradiation of the thyroid may increase the risk of Graves` disease or euthyroid Graves` ophthalmopathy. Silent thyroiditis, cystic degeneration, benign adenoma, and thyroid cancer have been observed after therapeutically relevant doses of external radiation. Direct or incidental thyroid irradiation increases the risk for well-differentiated, papillary, and follicular thyroid cancer from 15- to 53-fold. Thyroid cancer risk is highest following radiation at a young age, decreases with increasing age at treatment, and increases with follow-up duration. The potentially prolonged latent period between radiation exposure and the development of thyroid dysfunction, thyroid nodularity, and thyroid cancer means that individuals who have received neck or pituitary irradiation require careful, periodic clinical and laboratory evaluation to avoid excess morbidity. 39 refs.

Hancock, S.L.; McDougall, I.R. [Stanford Univ. School of Medicine, Stanford, CA (United States); Constine, L.S. [Strong Memorial Hospital, Rochester, NY (United States)

1995-03-30

422

Osteoarthritis associated with mild chondrodysplasia in transgenic mice expressing alpha 1(IX) collagen chains with a central deletion.  

PubMed Central

Type IX collagen, containing molecules of the three distinct polypeptides alpha 1(IX), alpha 2(IX), and alpha 3(IX), is an interesting hybrid extracellular matrix component in cartilage and eye tissues, with the properties of both a proteoglycan and a collagen. The alpha 1 (IX) chain has two forms, as a result of the tissue-specific utilization of two alternative promoters; the alpha 2(IX) chain carries a covalently attached glycosaminoglycan side chain. We have introduced a gene construct controlled by a tissue-specific promoter/enhancer and expressing a truncated alpha 1(IX) chain into mice. Examination of the offspring of two different founders revealed pathological changes similar to osteoarthritis in the articular cartilage of knee joints. In addition, mice homozygous for the transgene developed mild chondrodysplasia (i.e., mild dwarfism, anterior tonguing in the vertebral bodies, and ophthalmopathy). The relative ratio of transgene product to the endogenous alpha 1(IX) chain was approximately one in homozygotes and less than one in heterozygotes. Therefore, the phenotypic severity correlated well with the level of transgene expression. These findings suggest that mutations in type IX collagen genes may cause certain forms of osteoarthritis and chondrodysplasia in humans. Images Fig. 2 Fig. 3 Fig. 5 Fig. 6

Nakata, K; Ono, K; Miyazaki, J; Olsen, B R; Muragaki, Y; Adachi, E; Yamamura, K; Kimura, T

1993-01-01

423

Graves? orbitopathy: Management of difficult cases  

PubMed Central

Management of Graves? ophthalmopathy (GO) is based on three pillars: to stop smoking, to restore and maintain euthyroidism, and to treat the eye changes according to severity and activity of GO. Difficulties are frequently encountered in each of these three management issues. The advice to discontinue smoking is straightforward, but just a small minority of smokers is able to quit smoking. Detailed information on how smoking adversely affects the outcome of Graves? disease may convince patients they have to stop smoking right away. Controversy exists on the most appropriate treatment of Graves? hyperthyroidism in the presence of GO. 131I therapy is associated with a risk of about 15% for worsening of GO; a preventive course of steroids is indicated in the presence of risk factors (smoking, biochemically severe hyperthyroidism, high level of TSH receptor antibodies, active GO). Alternatives are thyroidectomy or long-term treatment with antithyroid drugs, which apparently are rather neutral with respect to the course of GO. Mild GO is not always perceived as being mild by the patients themselves. Selenium improves mild GO. Moderate-to-severe GO is preferably treated with intravenous methylprednisolone pulses, but serious side effects and relapsing GO do occur. After steroid failure combination therapy with low-dose oral prednisone with either cyclosporine or retrobulbar irradiation can be effective. Dysthyroid optic neuropathy is best treated with IV pulses, followed by orbital decompression if visual functions do not improve. In resistant cases, rituximab might be considered, although failures of this drug are also described.

Wiersinga, Wilmar M.

2012-01-01

424

Management of the nontoxic multinodular goiter: a North American survey.  

PubMed

To assess approaches to the diagnosis and therapy of patients with nontoxic multinodular goiter, a questionnaire was circulated to all members of the American Thyroid Association (ATA). An index case report was presented (42-yr-old woman with an irregular, nontender, bilaterally enlarged thyroid of 50-80 g and no clinical suspicion of malignancy or thyroid dysfunction), and 11 variations were proposed to evaluate how each alteration would affect management. One hundred and forty responses were retained (approximately 50% of clinically active ATA members). For the index case, a TSH determination was the routine choice of 100%, and serum thyroid autoantibodies were measured by 74%. Simultaneous use of serum TSH, a thyroid hormone assay, and antithyroid peroxidase was employed by 49%. Only 4% included a calcitonin assay. The median number of blood tests ordered was 3 (range, 1-7). Ultrasound was used by 59%, thyroid scintigraphy by 24%, and both imaging modalities by 11%. Fine needle aspiration biopsy (FNAB) was performed by 74%. If scintigraphy showed inhomogeneous tracer distribution or a dominant hypofunctioning region, FNAB was performed by 15% and 97%, respectively. L-T4 treatment was preferred by 56%, radioiodine by 1%, surgery by 6%, and 36% would recommend no treatment. A large goiter, a history of external radiation, or rapid growth increased the preference for surgery. In case of a suppressed serum TSH level, radioiodine was used by 56%. In conclusion, in the work-up of patients with nontoxic multinodular goiter, ATA clinicians employ determinations of TSH often combined with a T4 and/or T3 assay and antithyroid peroxidase antibodies. Thyroid imaging, primarily ultrasound, is performed by more than two thirds, and FNAB by three fourths. This diagnostic evaluation is significantly less extensive than that of the European Thyroid Association members, but the distribution of treatment choices is quite similar. In accordance with their European colleagues, the majority of ATA members prefer the use of L-T4 therapy. There is, however, still a wide variation in the perceived optimal management of this condition among members of both organizations. PMID:11788632

Bonnema, Steen J; Bennedbaek, Finn N; Ladenson, Paul W; Hegedüs, Laszlo

2002-01-01

425

From One Extreme to Another: Tsunami, Hurricane, and El Niño Observations from the NDBC Ocean Observing Systems of Systems  

NASA Astrophysics Data System (ADS)

NOAA`s National Data Buoy Center (NDBC) operates a system of ocean observing systems (NOOSS) to provide critical information in real-time during extreme events, such as tsunamis, hurricanes, and El Niños. NDBC recently completed the 39-station array of tsunameters that employ the second-generation Deep-ocean and Assessment and Reporting of Tsunamis (DART II) technology. The tsunameter array spans the Pacific Ocean and the western Atlantic Ocean providing real-time water-level measurements and tsunami detection times. At depths down to 6000 meters the tsunameters can send information in less than 3 minutes to the Tsunami Warning Centers in Hawaii and Alaska and to the international tsunami community. The tsunameters have provided data for the Kuril tsunamis of November 2006 and January 2007, the Peru tsunamis of August and September 2007, and the southern Sumatra tsunami of September 2007. In 2006, NDBC assumed operations of the Tropical Atmosphere Ocean Array (TAO), the "crown jewel" of the Global Climate Observation System. TAO provides real-time data for improved detection, understanding, and prediction of El Niño and La Niña. The 55-buoy TAO array spans the central and eastern equatorial Pacific. Real-time and post-deployment recovery data support climate analysis and forecasts. For more than 30 years, NDBC has operated a system of buoys and coastal automated stations for meteorological and oceanographic observations that support real-time weather analysis, forecasting, and warnings. These "traditional" NDBC stations measure winds, waves, temperature, and humidity routinely. Some stations are augmented with ocean current and temperature and salinity (conductivity) sensors. In recent years, among the Gulf of Mexico and Caribbean hurricanes passing in proximity to NDBC stations include Ivan in 2004, Cindy, Emily, Dennis, Katrina, Rita, and Wilma in 2005, Ernesto in 2006, and Dean and Felix in 2007 as well as numerous tropical storms. Not confined to tropical systems, NDBC's observing systems reach as far north as the Bering Sea and have provided data for numerous extreme high winds and sea conditions, including the memorable Halloween Nor`easter of 1991 and the December 2007 storm off the Pacific Northwest. The three systems of the NOOSS comprise a network of more than 200 observing stations. While much of NDBC`s efforts are employed in the maintenance and operation of the stations, NDBC`s mission is not complete until the forecasters, scientists, and maritime safety community receive the timely and accurate data for real-time decision-making. Furthering that mission, NDBC`s Data Assembly Center (DAC) continuously monitors data from the NOOSS stations and performs automated quality before distributing the data in standard formats of the World Meteorological Organization via its Global Telecommunications System and the NDBC web site (http://www.ndbc.noaa.gov) in real-time. NDBC`s DAC also assembles and performs further quality analysis and control before assembling data for permanent archive to improve the understanding and prediction of extreme events. Underscoring both the breadth and the depth of the NOOSS, in 2007, for the first time a hurricane, Hurricane Flossie in the Central Pacific, passed within 300 nautical miles of all three types of NDBC stations making meteorological, oceanographic, and water-level measurements.

Bouchard, R. H.; Henderson, D.; Locke, L.

2008-05-01

426

Observing Natural Hazards: Tsunami, Hurricane, and El Niño Observations from the NDBC Ocean Observing System of Systems  

NASA Astrophysics Data System (ADS)

The National Oceanic and Atmospheric Administration’s (NOAA) National Data Buoy Center (NDBC) operates and maintains the NDBC Ocean Observing Systems of Systems (NOOSS), comprised of 3 networks that provide critical information before and during and after extreme hazards events, such as tsunamis, hurricanes, and El Niños. While each system has its own mission, they have in common the requirement to remain on station in remote areas of the ocean to provide reliable and accurate observations. After the 2004 Sumatran Tsunami, NOAA expanded its network of tsunameters from six in the Pacific Ocean to a vast network of 39 stations providing information to Tsunami Warning Centers to enable faster and more accurate tsunami warnings for coastal communities in the Pacific, Atlantic, Caribbean and the Gulf of Mexico. The tsunameter measurements are used to detect the amplitude and period of the tsunamis, and the data can be assimilated into models for the prediction and impact of the tsunamis to coastal communities. The network has been used for the detection of tsunamis generated by earthquakes, including the 2006 and 2007 Kuril Islands, 2007 Peru, and Solomon Islands, and most recently for the 2009 Dusky Sound, New Zealand earthquake. In August 2009, the NOAA adjusted its 2009 Atlantic Hurricane Seasonal Outlooks from above normal to near or below normal activity, primarily due to a strengthening El Niño. A key component in the detection of that El Niño was the Tropical Atmosphere Ocean Array (TAO) operated by NDBC. TAO provides real-time data for improved detection, understanding, and prediction of El Niño and La Niña. The 55-buoy TAO array spans the central and eastern equatorial Pacific providing real-time and post-deployment recovery data to support climate analysis and forecasts. Although, in this case, the El Niño benefits the tropical Atlantic, the alternate manifestation, La Niña typically enhances hurricane activity in the Atlantic. The various phases of the El Niño-Southern Oscillation resulting in extreme hazards, such as floods and landslides, droughts and wildfires, fish kills and biological impacts. For almost 40 years, NDBC has operated and maintained a network of buoys and coastal automated stations for meteorological and oceanographic observations that support real-time weather analysis, forecasting, and warnings. The US National Hurricane Center (NHC) uses the observations from the buoys to detect the position and intensity of tropical cyclones and the extent of their extreme winds and sea. Since 2006, NHC has cited over 100 instances of using buoy data in its Forecast Discussions or Public Advisories. Data are also used in reconstructing and analyzing the extent of devastation from land-falling hurricanes. The unprecedented devastation caused by the rising waters of 2005’s Hurricane Katrina was attributed to the waves generated and reported by the NDBC buoys in the Gulf of Mexico superimposed upon the storm surge at landfall. The three constituent systems of the NOOSS comprise a network of more than 250 observing stations providing real-time and archived data for forecasters, scientists, and disaster management officials.

O'Neil, K.; Bouchard, R.; Burnett, W. H.; Aldrich, C.

2009-12-01

427

Myxovirescin A biosynthesis is directed by hybrid polyketide synthases/nonribosomal peptide synthetase, 3-hydroxy-3-methylglutaryl-CoA synthases, and trans-acting acyltransferases.  

PubMed

Myxococcus xanthus DK1622 is shown to be a producer of myxovirescin (antibiotic TA) antibiotics. The myxovirescin biosynthetic gene cluster spans at least 21 open reading frames (ORFs) and covers a chromosomal region of approximately 83 kb. In silico analysis of myxovirescin ORFs in conjunction with genetic studies suggests the involvement of four type I polyketide synthases (PKSs; TaI, TaL, TaO, and TaP), one major hybrid PKS/NRPS (Ta-1), and a number of monofunctional enzymes similar to the ones involved in type II fatty-acid biosynthesis (FAB). Whereas deletion of either taI or taL causes a dramatic drop in myxovirescin production, deletion of both genes (DeltataIL) leads to the complete loss of myxovirescin production. These results suggest that both TaI and TaL PKSs might act in conjunction with a methyltransferase, reductases, and a monooxygenase to produce the 2-hydroxyvaleryl-S-ACP starter that is proposed to act as the biosynthetic primer in the initial condensation reaction with glycine. Polymerization of the remaining 11 acetates required for lactone formation is directed by 12 modules of Ta-1, TaO, and TaP megasynthetases. All modules, except for the first module of TaL, lack cognate acyltransferase (AT) domains. Furthermore, deletion of a discrete tandem AT-encoded by taV-blocks myxovirescin production; this suggests an "in trans" mode of action. To embellish the macrocycle with methyl and ethyl moieties, assembly of the myxovirescin scaffold is proposed to switch twice from PKS to 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA)-like biochemistry during biosynthesis. Disruption of the S-adenosylmethionine (SAM)-dependent methyltransferase, TaQ, shifts production toward two novel myxovirescin analogues, designated myxovirescin Q(a) and myxovirescin Q(c). NMR analysis of purified myxovirescin Q(a) revealed the loss of the methoxy carbon atom. This novel analogue lacks bioactivity against E. coli. PMID:16835859

Simunovic, Vesna; Zapp, Josef; Rachid, Shwan; Krug, Daniel; Meiser, Peter; Müller, Rolf

2006-08-01

428

Denudation of Actively Growing Mountain Ranges in the Foreland of NE Tibet Inferred From in- Situ Produced Cosmogenic Be-10  

NASA Astrophysics Data System (ADS)

At the northeastern edge of the Tibetan Plateau ranges bounded by active thrust faults offer the unique opportunity to study the competing effects of uplift and erosion during the early stages of mountain building. Owing to along- strike variations in relief, slope, and lithology, these ranges are an ideal target for studying the influence of topography, lithology, and active faulting on denudation. Here we report spatially-averaged erosion rates for catchments situated along two of these ranges based on Be-10 concentrations of quartz in stream sediments. The Yumu Shan and the western Long Shou Shan are about 60 km long and their overall shape as well as the presence of wind gaps illustrates their vertical-lateral growth during Plio-Quaternary thrust faulting (Hetzel et al. 2004a). Erosion rates determined so far for 20 small catchments are variable and range from 20 to 550 mm/kyr. The observed variability results from at least three factors: (1) the erosion rate in catchments exposing the same lithology is positively correlated with relief and mean slope, (2) weakly consolidated Cretaceous sediments generally erode faster than low-grade Paleozoic bedrock, and (3) the erosion rate seems to decrease from the centre of the fault-bounded ranges towards their propagating tips. As rates of thrust faulting and rock uplift in the region (600-1200 mm/kyr; Hetzel et al., 2004a, b) exceed the denudation rates, the active growth of mountains and the lateral growth of Tibet has not yet come to rest. References Hetzel, R., Tao, M., Niedermann, S., Strecker, M.R., Ivy-Ochs, S., Kubik, P.W., Gao, B. (2004a). Implications of the fault scaling law for the growth of topography: Mountain ranges in the broken foreland of NE Tibet, Terra Nova 16, 157-162. Hetzel, R., Tao, M., Stokes, S., Niedermann, S., Ivy-Ochs, S., Gao, B., Strecker, M.R., Kubik, P.W. (2004b). Late Pleistocene-Holocene slip rate of the Zhangye thrust (Qilian Shan, China) and implications for the active growth of the northeastern Tibetan Plateau, Tectonics 23 (6), TC6006, doi:10.1029/2004TC001653.

Palumbo, L.; Hetzel, R.; Tao, M.; Li, X.

2007-12-01

429

Evolution of the cross-equatorial atmospheric boundary layer in the east Pacific: Observations and models  

NASA Astrophysics Data System (ADS)

The NCAR C-130 research aircraft flew eight missions observing the atmospheric boundary layer (ABL) along 95°W, 1°S--12°N. The positive air-sea temperature difference over the equatorial cold tongue results in a shallow stable layer with reduced surface winds. Stratocumulus clouds at the ABL top tend to clear over the cold water, especially at times of enhanced humidity above the ABL. In the 0°--4°N ABL heat budget, cold advection and radiative cooling were balanced by surface and entrainment heating, where each of the four terms was about 30 W m-2. The humidity budget was a near balance between dry advection and surface evaporation (each about 150 W m-2). The entrainment rate estimated from the downstream-deepening of the inversion was 12 +/- 3 mm s -1. Principal component analysis of the sea-level pressure along 95°W, 1°S--12°N from daily TAO buoy observations and the eight flights shows that the principal mode of variability in the perturbation pressure explains 77% of the pressure variability. The pressure anomalies are the same at 1.6 km as at the surface. The timeseries of the first mode of the TAO observations shows that most of the variance is in the 2--7 day window. Low pressure at 12°N is associated with southerly and westerly surface wind anomalies, and enhanced convection in the ITCZ. A "quasi-Lagrangian" large-eddy simulation (LES) is used to model the ABL along 95°W from 8°S to 4°N. Large-scale tendencies are prescribed as a function of latitude. Surface stability accounts for the minimum in surface wind over the equatorial cold tongue and the maximum over the warm water to the north, in accordance with Wallace, Mitchell, and Deser (1989). Additional simulations show the robustness of the model ABL to changes in pressure gradients, zonal advection, free-tropospheric humidity, and initial conditions. Once formed at the southern edge of the cold tongue, modeled stratus clouds demonstrate a remarkable ability to maintain themselves over the cold tongue by radiative cooling at their tops.

de Szoeke, Simon P.

430

Reflections on the theory of "silver bullet" octreotide tracers: implications for ligand-receptor interactions in the age of peptides, heterodimers, receptor mosaics, truncated receptors, and multifractal analysis  

PubMed Central

The classical attitude of Nuclear Medicine practitioners on matters of peptide-receptor interactions has maintained an intrinsic monogamic character since many years. New advances in the field of biochemistry and even in clinical Nuclear Medicine have challenged this type of thinking, which prompted me to work on this review. The central issue of this paper will be the use of somatostatin analogs, i.e., octreotide, in clinical imaging procedures as well as in relation to neuroendocirne tumors. Newly described characteristics of G-protein coupled receptors such as the formation of receptor mosaics will be discussed. A small section will enumerate the regulatory processes found in the cell membrane. Possible new interpretations, other than tumor detection, based on imaging procedures with somatostatin analogs will be presented. The readers will be taken to situations such as inflammation, nociception, mechanosensing, chemosensing, fibrosis, taste, and vascularity where somatostatin is involved. Thyroid-associated orbitopathy will be used as a model for the development of multi-agent therapeutics. The final graphical summary depicts the multifactorial properties of ligand binding.

2011-01-01

431

Diagnostic utility of PETCT in thyroid malignancies: an update.  

PubMed

The primary clinical application of (18)F FDG PET/CT ((18)Fluorine labeled flurodeoxyglucose positron emission tomography/computed tomography) in differentiated thyroid carcinoma is in the identification of active disease in thyroglobulin (Tg) positive (>10 ng/ml), whole body iodine scan negative patients. The impact of FDG PET/CT in diagnosis, surveillance, cure, and progression-free survival of differentiated thyroid carcinoma patients remains to be seen. Five main indications of FDG PET/CT in thyroid cancer have been recommended by revised American thyroid association guidelines 2009. This review aims to provide a complete picture of PET imaging in thyroid malignancies and enumerates each indication with literature review. This review also highlights recent advances in targeted molecular imaging. Currently differentiated thyroid cancer is best imaged using conventional single photon emission computed tomography-based radioiodine tracers ((123)I/(131)I). Although the utility of FDG PET in well differentiated thyroid cancer patients who are iodine negative but with raised Tg is well established, evidence is emerging on the advantages of FDG PET/CT in other histological types of thyroid malignancy, such as Hurthle cell, medullary, and the anaplastic malignancies. Novel PET radiotracers, such as (124)Iodine ((124)I), (18)F-DOPA (3,4-dihydroxy-L-phenylalanine), and (68)Ga-DOTA peptides are revolutionizing the way thyroid malignancies are imaged. Newer concepts on targeted molecular imaging and theranostics are ushering in new possibilities for imaging and treating thyroid cancer. PMID:23801405

Palaniswamy, Shanmuga Sundaram; Subramanyam, Padma

2013-06-26

432

Teratology Public Affairs Committee Position Paper: Iodine Deficiency in Pregnancy  

PubMed Central

Iodine deficiency is an important nutritional deficiency, with more than 2 billion people worldwide estimated to be at risk. The developing fetus and young children are particularly at risk. During pregnancy and lactation, iodine requirements increase, whether in iodine-poor or iodine-sufficient countries, making the mother and the developing fetus vulnerable. The American Thyroid Association (ATA) recommends 250 micrograms per day of iodine intake for pregnant and lactating women. The thyroid gland is able to adapt to the changes associated with pregnancy as long as sufficient iodine is present. Dietary intake is the sole source of iodine, which is essential to the synthesis of thyroid hormones. Iodine is found in multiple dietary sources including iodized salt, dairy products, seaweed, and fish. Prenatal vitamins containing iodine are a good source of iodine, but iodine content in multivitamin supplements is highly variable. Congenital hypothyroidism is associated with cretinism. Clinical hypothyroidism has been associated with increased risk of poor perinatal outcome including prematurity, low birth weight, miscarriage, preeclampsia, fetal death, and impaired fetal neurocognitive development. Subclinical hypothyroidism is also associated with poor pregnancy outcomes and potential fetal neurocognitive deficits, but the data are more variable than those for clinical hypothyroidism. We concur with the ATA recommendation that all pregnant and lactating women should ingest (through diet and supplements) 250 micrograms of iodine daily. To achieve this goal, we recommend that all pregnant and lactating women take daily iodine supplementation of 150 micrograms.

Obican, Sarah G.; Jahnke, Gloria D.; Soldin, Offie P.; Scialli, Anthony R.

2013-01-01

433

Neurofibromatosis Type 1 Associated with Hashimoto's Thyroiditis: Coincidence or Possible Link  

PubMed Central

Introduction. Hashimoto's thyroiditis is a common form of chronic autoimmune thyroid disease (AITD) and often coexists with other autoimmune diseases, but Hashimoto's thyroiditis associated with an autosomal dominant neurofibromatosis type 1 is exceedingly rare. Case Presentation. A 30-year-old Bengali woman presented to the OPD with complaints of aching pain and tingling sensation in her hands and feet. Physical examination revealed dysmorphic facies, nodular swelling in the neck, cafe-au-lait spots, and neurofibromas covering the entire surface of her body. Her thyroid hormones were within normal limits. Thyroid ultrasound revealed a cystic area in the left lobe of the gland, and ultrasound-guided fine needle aspiration cytology revealed lymphocytic infiltration of the gland, suggesting Hashimoto's thyroiditis. High levels of autoimmune antibodies such as antithyroglobulin and antimicrosomal antibodies confirmed the diagnosis. Conclusion. When encountered with a patient of Neurofibromatosis type 1, a physician should be careful about the possibility of a concomitant autoimmune disease. Clinical presentation of neurofibromatosis and Noonan syndrome often overlaps and recent studies have implicated a mutation in NF1 gene in the etiology of NFNS. More extensive reports and further investigations of such patients having combination of neurofibromatosis type 1 and autoimmune thyroiditis will certainly provide better understanding of this link in the near future.

Nabi, Junaid

2013-01-01

434

The presence of non-segmental vitiligo modifies intracellular cytokine subsets in patients with chronic lymphocytic thyroiditis.  

PubMed

Chronic lymphocytic thyroiditis and vitiligo often occur in association and seem to be characterized by a prevalent Th1-driven autoimmune process. The aim of this study is to analyze selected intracellular ?h1 and Th2 cytokines in patients with Hashimoto?s thyroiditis when associated with non-segmental vitiligo. We analyzed intracellular interleukin-2, interferon-gamma (?h1) and interleukin-4 (Th2), in peripheral blood lymphocytes of 23 patients with isolated Hashimoto?s thyroiditis (group A) and of 11 patients with Hashimoto?s thyroiditis associated with non-segmental vitiligo (group B). Peripheral blood lymphocytes were stimulated and incubated with specific monoclonal antibodies. Intracellular cytokines were assayed by flow cytometric analysis. Interleukin-2 and interferon-gamma positive cells were increased in almost all patients but the median values were similar in patients with isolated Hashimoto?s thyroiditis and in those with concurrent vitiligo. In contrast, the number of patients with increased interleukin-4 positive cells was higher in patients with thyroiditis and vitiligo (9/11) than in those with isolated thyroiditis (2/23; p<0.0001). The median values of IL-4 positive cells in the two groups confirmed this difference (A: 5.8 percent, vs B: 20.6 percent; p=0.0011). Increased interleukin-4 positive lymphocytes characterize Hashimoto?s thyroiditis when associated with non-segmental vitiligo, suggesting a modified balance from highly prevalent Th1 to mixed Th1/Th2 subset. PMID:21244769

Santaguida, M G; Del Duca, S C; Virili, C; Gargano, L; Centanni, M

435

Neurofibromatosis Type 1 Associated with Hashimoto's Thyroiditis: Coincidence or Possible Link.  

PubMed

Introduction. Hashimoto's thyroiditis is a common form of chronic autoimmune thyroid disease (AITD) and often coexists with other autoimmune diseases, but Hashimoto's thyroiditis associated with an autosomal dominant neurofibromatosis type 1 is exceedingly rare. Case Presentation. A 30-year-old Bengali woman presented to the OPD with complaints of aching pain and tingling sensation in her hands and feet. Physical examination revealed dysmorphic facies, nodular swelling in the neck, cafe-au-lait spots, and neurofibromas covering the entire surface of her body. Her thyroid hormones were within normal limits. Thyroid ultrasound revealed a cystic area in the left lobe of the gland, and ultrasound-guided fine needle aspiration cytology revealed lymphocytic infiltration of the gland, suggesting Hashimoto's thyroiditis. High levels of autoimmune antibodies such as antithyroglobulin and antimicrosomal antibodies confirmed the diagnosis. Conclusion. When encountered with a patient of Neurofibromatosis type 1, a physician should be careful about the possibility of a concomitant autoimmune disease. Clinical presentation of neurofibromatosis and Noonan syndrome often overlaps and recent studies have implicated a mutation in NF1 gene in the etiology of NFNS. More extensive reports and further investigations of such patients having combination of neurofibromatosis type 1 and autoimmune thyroiditis will certainly provide better understanding of this link in the near future. PMID:23691379

Nabi, Junaid

2013-04-18

436

The Role of Prophylactic Central Neck Dissection in Differentiated Thyroid Carcinoma: Issues and Controversies  

PubMed Central

Prophylactic central neck dissection (pCND) in differentiated thyroid carcinoma (DTC) is one of the most controversial surgical subjects in recent times. To date, there is little evidence to support the practice of pCND in patients with DTC undergoing total thyroidectomy. Although the recently revised American Thyroid Association (ATA) guideline has clarified many inconsistencies regarding pCND and has recommended pCND in “high-risk” patients, many issues and controversies surrounding the subject of pCND in DTC remain. The recent literature has revealed an insignificant trend toward lower recurrence rate in patients with DTC who undergo total thyroidectomy and pCND than those who undergo total thyroidectomy alone. However, this was subjected to biases, and there are concerns whether pCND should be performed by all surgeons who manage DTC because of increased surgical morbodity. Performing a unilateral pCND may be better than a bilateral pCND given its lower surgical morbidity. Further studies in this controversial subject are much needed.

Wong, Kai-Pun; Lang, Brian Hung-Hin

2011-01-01

437

de Quervain thyroiditis in a young boy following hand-foot-mouth disease.  

PubMed

de Quervain thyroiditis, also known as subacute thyroiditis, is a self-limited inflammatory disease of the thyroid gland. It is extremely rare in children. The hallmarks for diagnosis are painful thyroid enlargement, elevated inflammatory markers, and decreased uptake of the thyroid gland on thyroid scintigraphy. Viral infection has been proposed to be associated with de Quervain thyroiditis. Coxsackie virus has been reported to be one of the viruses associated with the disease. To our knowledge, childhood de Quervain thyroiditis associated with hand-foot-mouth disease caused by coxsackie infection has never been reported. We report a 2.7-year-old boy who presented with typical features of de Quervain thyroiditis following hand-foot-mouth disease caused by coxsackie B4 infection. He had a brief thyrotoxic phase initially, followed by transient hypothyroid phase and euthyroidism thereafter. His thyroid scintigraphy showed a typical faint uptake at the diagnosis, and an improvement of the thyroid scan and uptake was shown 8 weeks later. He was treated with prednisolone and nearly complete resolution was documented within 2 months. Careful evaluation of the patient led to the correct diagnosis and appropriate management. PMID:20886354

Engkakul, Pontipa; Mahachoklertwattana, Pat; Poomthavorn, Preamrudee

2010-10-01

438

Subacute thyroiditis in the course of novel H1N1 influenza infection.  

PubMed

To describe the first documented case of subacute (De Quervain) thyroiditis in the course of novel H1N1 influenza infection. This is a case report of a patient diagnosed at the General Hospital "G. Hatzikosta" of Ioannina, Greece. A 55-year-old previously healthy male developed an influenza-like syndrome that was accompanied by severe neck pain, palpitations, weight loss, and disproportionately increased erythrocyte sedimentation rate. Polymerase chain reaction assay of pharyngeal swabs confirmed the diagnosis of novel H1N1 influenza infection. Serum thyroid-stimulating hormone was suppressed to zero and levels of free thyroxine and particularly triiodothyronine were increased. Technetium-99m-pertechnetate scintigraphy showed diffuse and inhomogeneous very low technetium trapping. The patient was treated with non-steroidal anti-inflammatory drugs and thyroid function gradually normalized without evolving to a hypothyroid phase. This is the first case of subacute thyroiditis associated with novel H1N1 influenza infection. Furthermore, this is the first case to definitely demonstrate active influenza infection of any type concurrent with thyroiditis, and one of the very rare similar cases for any active viral disease etiologically implicated in the pathogenesis of subacute thyroiditis. PMID:20960165

Dimos, Georgios; Pappas, Georgios; Akritidis, Nikolaos

2010-03-30

439

The Role of Fluorine-18-Fluorodeoxyglucose Positron Emission Tomography in Aggressive Histological Subtypes of Thyroid Cancer: An Overview  

PubMed Central

Aggressive histological subtypes of thyroid cancer are rare and have a poor prognosis. The most important aggressive subtypes of thyroid cancer are Hürthle cell carcinoma (HCTC) and anaplastic and poorly differentiated carcinoma (ATC and PDTC). The American Thyroid Association recently published guidelines for the management of patients with ATC, but no specific guidelines have been done about HCTC. We performed an overview of the literature about the role of Fluorine-18-Fluorodeoxyglucose positron emission tomography or positron emission tomography/computed tomography (FDG-PET or PET/CT) in aggressive histological subtypes of thyroid cancer. Only few original studies about the role of FDG-PET or PET/CT in HCTC, PDTC, and ATC have been published in the literature. FDG-PET or PET/CT seems to be useful in staging or followup of invasive and metastatic HCTC. FDG-PET or PET/CT should be used in patients with ATC in initial staging and in the followup after surgery to evaluate metastatic disease. Some authors suggest the use of FDG-PET/CT in staging of PDTC, but more studies are needed to define the diagnostic use of FDG-PET/CT in this setting. Limited experience suggests the usefulness of FDG-PET or PET/CT in patients with more aggressive histological subtypes of DTC. However, DTC presenting as radioiodine refractory and FDG-PET positive should be considered aggressive tumours with poor prognosis.

Treglia, Giorgio; Annunziata, Salvatore; Muoio, Barbara; Salvatori, Massimo; Ceriani, Luca; Giovanella, Luca

2013-01-01

440

Hypothyroxinemia Induced by Mild Iodine Deficiency Deregulats Thyroid Proteins during Gestation and Lactation in Dams  

PubMed Central

The main object of the present study was to explore the effect on thyroidal proteins following mild iodine deficiency (ID)-induced maternal hypothyroxinemia during pregnancy and lactation. In the present study, we established a maternal hypothyroxinemia model in female Wistar rats by using a mild ID diet. Maternal thyroid iodine content and thyroid weight were measured. Expressions of thyroid-associated proteins were analyzed. The results showed that the mild ID diet increased thyroid weight, decreased thyroid iodine content and increased expressions of thyroid transcription factor 1, paired box gene 8 and Na+/I? symporter on gestational day (GD) 19 and postpartum days (PN) 21 in the maternal thyroid. Moreover, the up-regulated expressions of type 1 iodothyronine deiodinase (DIO1) and type 2 iodothyronine deiodinase (DIO2) were detected in the mild ID group on GD19 and PN21. Taken together, our data indicates that during pregnancy and lactation, a maternal mild ID could induce hypothyroxinemia and increase the thyroidal DIO1 and DIO2 levels.

Wei, Wei; Wang, Yi; Dong, Jing; Wang, Yuan; Min, Hui; Song, Binbin; Shan, Zhongyan; Teng, Weiping; Xi, Qi; Chen, Jie

2013-01-01

441

A{sup -2} {yields} G transition at the 3{prime} acceptor splice site of IVS17 characterizes the COL2A1 gene mutation in the original Stickler syndrome kindred  

SciTech Connect

Hereditary progressive arthro-ophthalmopathy, or {open_quotes}Stickler syndrome,{close_quotes} is an autosomal dominant osteochondrodysplasia characterized by a variety of ocular and skeletal anomalies which frequently lead to retinal detachment and precocious osteoarthritis. A variety of mutations in the COL2A1 gene have been identified in {open_quotes}Stickler{close_quotes} families; in most cases studied thus far, the consequence of mutation is the premature generation of a stop codon. We report here the characterization of a COL2A1 gene mutation in the original kindred described by Stickler et al. Conformational sensitive gel electrophoresis (CSGE) was used to screen for mutations in the entire COL2A1 gene in an affected member from the kindred. A prominent heteroduplex species was noted in the polymerase chain reaction (PCR) product from a region of the gene including exons 17 to 20. Direct sequencing of PCR-amplified genomic DNA resulted in the identification of a base substitution at the A{sup -2} position of the 3{prime} splice acceptor site of IVS17. Sequencing of DNA from affected and unaffected family members confirmed that the mutation segregated with the disease phenotype. Reverse transcriptase-PCR analysis of poly A+ RNA demonstrated that the mutant allele utilized a cryptic splice site in exon 18 of the gene, eliminating 16 bp at the start of exon 18. This frameshift eventually results in a premature termination codon. These findings are the first report of a splice site mutation in classical Stickler syndrome and they provide a satisfying historical context in which to view COL2A1 mutations in this dysplasia. 25 refs., 3 figs., 1 tab.

Williams, C.J.; Ganguly, A.; Considine, E. [Thomas Jefferson Univ., Philadelphia, PA (United States)] [and others

1996-06-14

442

Analysis of four families with the Stickler syndrome by linkage studies. Identification of a new premature stop codon in the COL2A1 gene in a family  

SciTech Connect

The Stickler syndrome is an arthro-ophthalmopathy which associates progressive myopia with vitreal degeneration and retinal detachment. Cleft palate, cranio-facial abnormalities, deafness and osteoarthritis are often associated symptoms. Genetic heterogeneity of this autosomal dominant disease was consistent with its large clinical variability. Linkage studies have provided evidence for cosegregation of the disease with COL2A1, the gene coding for type II collagen, in about 50% of the families. Four additional families are reported here. Linkage analyses by using a VNTR located in the 3{prime} region of the gene were achieved. In three families, positive lod scores were obtained with a cumulative maximal value of 3.5 at a recombination fraction of 0. In one of these families, single strand conformation analysis of 25 exons disclosed a new mutation in exon 42. Codon for glutamic acid at position a1-803 was converted into a stop codon. The mutation was detected in DNA samples from all the affected members of the family but not in the unaffected. This result confirms that most of the Stickler syndromes linked to COL2A1 are due to premature stop codons. In a second family, an abnormal SSCP pattern of exon 34 was detected in all the affected individuals. The mutation is likely to correspond to a splicing defect in the acceptor site of intron 33. In one family the disease did not segregate with the COL2A1 locus. Further linkage studies with intragenic dimorphic sites in the COL10A1 gene and highly polymorphic markers close to the COL9A1 locus indicated that this disorder did not result from defects in these two genes.

Bonaventure, J.; Lasselin, C. [Hopital Necker, Paris (France); Toutain, A. [CHU Bretonneau, Tours (France)] [and others

1994-09-01

443

Epitopes, immunoglobulin classes and immunoglobulin G subclasses of calsequestrin antibodies in patients with thyroid eye disease.  

PubMed

A number of serum autoantibodies are associated with thyroid eye disease (TED), including those reactive against the calcium binding protein calsequestrin (CASQ). There are two isoforms of CASQ namely; CASQ1, found in skeletal, including extra ocular, muscle, and CASQ2, found in cardiac muscle. We determined (i) the reactivity profiles of CASQ1 and CASQ2 antibodies and (ii) the immunoglobulin (Ig) classes and IgG subclasses of CASQ1 antibodies, using enzyme-linked immunosorbent assay. Of the 20 patients with TED tested, 35% were positive for CASQ1 antibodies, 25% for CASQ2 antibodies and two patients (10%) were positive for both antibodies. Of the 12 patients with Hashimoto's thyroiditis and ophthalmopathy tested, 25% were positive for CASQ1 antibodies, 42% for CASQ2 antibodies and two patients (17%) were positive for both antibodies. CASQ1 antibodies were mainly of the IgG class and IgG1 and IgG3 subclasses. These results suggest that CASQ1 and CASQ2 do not share major epitopes. Because antibodies of the IgG1 and IgG3 subclasses are cytotoxic, CASQ1 antibodies may contribute to the eye muscle damage in patients with TED. Because CASQ1 antibodies were positive in only a third of patients with active TED we are unable to draw conclusions about their role in its pathogenesis. On the other hand, a possible role of CASQ2 antibodies in the aetiology of the cardiac complications of Graves' disease is a new avenue for research and appears worthy of further investigation. PMID:20670117

de Haan, Sofie; Lahooti, Hooshang; Morris, Olivia; Wall, Jack R

2010-07-29

444

Thyroid cancer in Graves' disease: is surgery the best treatment for Graves' disease?  

PubMed

BACKGROUND: Graves' disease is a common cause of thyrotoxicosis. Treatment options include anti-thyroid medications or definitive therapy: thyroidectomy or radioactive iodine (I(131) ). Traditionally, I(131) has been the preferred definitive treatment for Graves' disease in New Zealand. Reports of concomitant thyroid cancer occurring in up to 17% of Graves' patients suggest surgery, if performed with low morbidity, may be the preferred option. The aim of this study was to determine the rate of thyroid cancer and surgical outcomes in a New Zealand cohort of patients undergoing thyroidectomy for Graves' disease. METHOD: This study is a retrospective review of Waikato region patients undergoing thyroid surgery for Graves' disease during the 10-year period prior to 1 December 2011. RESULTS: A total of 833 patients underwent thyroid surgery. Of these, 117 were for Graves' disease. Total thyroidectomy was performed in 82, near-total in 33 and subtotal in 2 patients. Recurrent thyrotoxicosis developed in one subtotal patient requiring I(131) therapy. There were two cases of permanent hypoparathyroidism and one of permanent recurrent laryngeal nerve palsy. Eight patients (6.8%) had thyroid cancer detected, none of whom had overt nodal disease. Five were papillary microcarcinomas (one of which was multifocal), two were papillary carcinomas (11?mm and 15?mm) and one was a minimally invasive follicular carcinoma. CONCLUSION: Thyroid cancer was identified in approximately 7% of patients undergoing surgery for Graves' disease. A low complication rate (<2%) of permanent hypoparathyroidism and nerve injury (<1%) supports surgery being a safe alternative to I(131) especially for patients with young children, ophthalmopathy or compressive symptoms. PMID:22985335