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Sample records for tze huang pzh

  1. Protective effects and potential mechanisms of Pien Tze Huang on cerebral chronic ischemia and hypertensive stroke

    PubMed Central

    2010-01-01

    Background Stroke caused by brain ischemia is the third leading cause of adult disability. Active prevention and early treatment of stroke targeting the causes and risk factors may decrease its incidence, mortality and subsequent disability. Pien Tze Huang (PZH), a Chinese medicine formula, was found to have anti-edema, anti-inflammatory and anti-thrombotic effects that can prevent brain damage. This study aims to investigate the potential mechanisms of the preventive effects of Pien Tze Huang on brain damage caused by chronic ischemia and hypertensive stroke in rats. Methods The effects of Pien Tze Huang on brain protein expression in spontaneously hypertensive rat (SHR) and stroke prone SHR (SHRsp) were studied with 2-D gel electrophoresis and mass spectrometric analysis with a matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF)/TOF tandem mass spectrometer and on brain cell death with enzyme link immunosorbent assay (ELISA) and immunostaining. Results Pien Tze Huang decreased cell death in hippocampus and cerebellum caused by chronic ischemia and hypertensive stroke. Immunostaining of caspase-3 results indicated that Pien Tze Huang prevents brain cells from apoptosis caused by ischemia. Brain protein expression results suggested that Pien Tze Huang downregulated QCR2 in the electron transfer chain of mitochondria preventing reactive oxygen species (ROS) damage and possibly subsequent cell death (caspase 3 assay) as caused by chronic ischemia or hypertensive stroke to hippocampus and cerebellum. Conclusion Pien Tze Huang showed preventive effects on limiting the damage or injury caused by chronic ischemia and hypertensive stroke in rats. The effect of Pien Tze Huang was possibly related to prevention of cell death from apoptosis or ROS/oxidative damage in mitochondria. PMID:20955558

  2. Pien Tze Huang suppresses the stem-like side population in colorectal cancer cells.

    PubMed

    Wei, Lihui; Chen, Pangyu; Chen, Youqin; Shen, Aling; Chen, Hongwei; Lin, Wei; Hong, Zhenfeng; Sferra, Thomas J; Peng, Jun

    2014-01-01

    Accumulating evidence suggests that a small population of cells termed cancer stem cells (CSCs) are crucial in tumor development and drug resistance, leading to cancer relapse and metastasis and eventually the failure of clinical cancer treatment. Therefore, targeting CSCs is a promising approach for anticancer therapies. Due to the drug resistance and adverse effects of currently used chemotherapies, traditional Chinese medicines (TCM) have recently received attention due to the relatively few side-effects. Thus, they have been used as important alternative remedies for various diseases, including cancer. Pien Tze Huang (PZH), a well-known TCM formula that was first prescribed more than 450 years ago in the Ming Dynasty, has been used in China and Southeast Asia for centuries as a folk remedy for various types of cancer. Previously, it was reported that PZH inhibits colon cancer growth via the promotion of cancer cell apoptosis and inhibition of cell proliferation and tumor angiogenesis, which is probably mediated by its regulatory effect on multiple intracellular signaling pathways. To elucidate the mechanism of the tumoricidal activity of PZH, the aim of the present study was to investigate the effect of PZH on CSCs that were isolated as the side population (SP) from the HT-29 colorectal cancer cell line. The results demonstrated that PZH significantly and dose-dependently reduced the percentage of the colorectal cancer stem-like SP cells, decreased the viability and sphere-forming capacity of HT-29 SP cells, indicating that PZH is potent in suppressing the growth of colorectal cancer stem cells. Moreover, PZH treatment in HT-29 SP cells markedly inhibited the mRNA levels of ABCB1 and ABCG2, which are members of the ABC transporter superfamily, thereby contributing to the SP phenotype and multi-drug resistance. Findings of the present study suggest that inhibiting the growth of CSCs is a potential mechanism by which PZH can be used in cancer treatment. PMID:24173665

  3. Methanolic Extract of Pien Tze Huang Induces Apoptosis Signaling in Human Osteosarcoma MG63 Cells via Multiple Pathways.

    PubMed

    Fu, Yong; Zhang, Li; Hong, Zhenqiang; Zheng, Haiyin; Li, Nan; Gao, Hongjian; Chen, Boyi; Zhao, Yi

    2016-01-01

    Pien Tze Huang (PZH) is a well-known traditional Chinese formulation and has long been used as an alternative remedy for cancers in China and Southeast Asia. Recently, antitumor activity of PZH on several tumors have been increasingly reported, but its antitumor activity and the possible action mechanism on osteosarcoma remains unclear. After treatment with PZH, cell viability of MG-63 cells was dose-dependently inhibited compared to control cells. Moreover, a DNA ladder characteristic of apoptosis was observed in the cells treated with PZH, especially 500 μg/mL, 750 μg/mL. Further investigation showed that PZH treatments led to activation of caspase cascades and changes of apoptotic mediators Bcl2, Bax, and Bcl-xL expression. In addition, our results suggested that PZH activated PI3K/Akt signal pathway, and the phosphorylation of Akt and ERK1/2 were associated with the induction of apoptotic signaling. These results revealed that PZH possesses antitumoral activity on human osteosarcoma MG63 cells by manipulating apoptotic signaling and multiple pathways. It is suggested that PZH alone or combined with regular antitumor drugs may be beneficial as osteosarcoma treatments. PMID:26938521

  4. How would composite traditional Chinese medicine protect the brain--an example of the composite formula "Pien Tze Huang".

    PubMed

    Zhang, L; Lam, W P; Lü, L; Wang, Y-X J; Wong, Y W; Lam, L H; Tang, H C; Wai, M S; Mak, Y T; Wang, M; Yew, D T

    2011-01-01

    Chinese medicine has a long history of several thousand years. The main form of Traditional Chinese Medicine (TCM) is composite, i.e. a mixture of up to 10 medicinal products. Thus a composite prescription of 4-5 kinds of Chinese medicinal products may contain several hundred kinds of chemical composition. The active ingredients and clinical efficacy of which are difficult to characterize. We aim to review the Chinese literature of TCMs with neuroprotective effects. We illustrate with our study on Pien Tze Huang (PZH) the use of in vivo tests in the study of composite TCM. Our results show evidence that PZH might have neuropreventive effects in rats. PMID:21756225

  5. Pien Tze Huang inhibits the proliferation of human colon carcinoma cells by arresting G1/S cell cycle progression

    PubMed Central

    SHEN, ALING; HONG, FEI; LIU, LIYA; LIN, JIUMAO; WEI, LIHUI; CAI, QIAOYAN; HONG, ZHENFENG; PENG, JUN

    2012-01-01

    Pien Tze Huang (PZH), a well-known traditional Chinese formula prescribed 450 years ago in the Ming Dynasty, has been used in China and Southeast Asia for centuries as a folk remedy for various types of cancer, including colorectal cancer (CRC). Recently, we reported that PZH is capable of inhibiting colon cancer growth both in vivo and in vitro via the promotion of apoptosis and inhibition of tumor angiogenesis. To elucidate the mechanism of the tumoricidal activity of PZH, its effect on the proliferation of human colon carcinoma Caco-2 cells was evaluated and the underlying molecular mechanism was investigated. Results showed that PZH inhibited Caco-2 cell viability and survival in a dose- and/or time-dependent manner. In addition, PZH treatment was found to block the G1/S cell cycle progression. Moreover, PZH suppressed the mRNA and protein expression of pro-proliferative Cyclin D1 and CDK4. Findings of the present study suggest that inhibition of cell proliferation via the G1/S cell cycle arrest is a potential mechanism by which PZH can be effective in the treatment of cancer. PMID:23205099

  6. Pien Tze Huang inhibits the proliferation of human colon carcinoma cells by arresting G1/S cell cycle progression.

    PubMed

    Shen, Aling; Hong, Fei; Liu, Liya; Lin, Jiumao; Wei, Lihui; Cai, Qiaoyan; Hong, Zhenfeng; Peng, Jun

    2012-10-01

    Pien Tze Huang (PZH), a well-known traditional Chinese formula prescribed 450 years ago in the Ming Dynasty, has been used in China and Southeast Asia for centuries as a folk remedy for various types of cancer, including colorectal cancer (CRC). Recently, we reported that PZH is capable of inhibiting colon cancer growth both in vivo and in vitro via the promotion of apoptosis and inhibition of tumor angiogenesis. To elucidate the mechanism of the tumoricidal activity of PZH, its effect on the proliferation of human colon carcinoma Caco-2 cells was evaluated and the underlying molecular mechanism was investigated. Results showed that PZH inhibited Caco-2 cell viability and survival in a dose- and/or time-dependent manner. In addition, PZH treatment was found to block the G1/S cell cycle progression. Moreover, PZH suppressed the mRNA and protein expression of pro-proliferative Cyclin D1 and CDK4. Findings of the present study suggest that inhibition of cell proliferation via the G1/S cell cycle arrest is a potential mechanism by which PZH can be effective in the treatment of cancer. PMID:23205099

  7. Pien Tze Huang inhibits tumor angiogenesis in a mouse model of colorectal cancer via suppression of multiple cellular pathways.

    PubMed

    Shen, Aling; Lin, Jiumao; Chen, Youqin; Lin, Wei; Liu, Liya; Hong, Zhenfeng; Sferra, Thomas J; Peng, Jun

    2013-10-01

    Angiogenesis plays an essential role in cancer progression, which therefore has become an attractive target for anticancer treatment. Tumor angiogenesis is tightly regulated by multiple signaling pathways that usually function redundantly; in addition, crosstalk between these pathways forms a complicated network that is regulated by compensatory mechanisms. Given the complexity of pathogenic mechanisms underlying tumor angiogenesis, most currently used angiogenesis inhibitors that only target single pathways may be insufficient and probably generate drug resistance, thus, increasing the necessity for development of novel anticancer agents. Traditional Chinese medicines (TCM) are receiving great interest since they have relatively fewer side-effects and have been used for thousands of years to clinically treat various types of diseases including cancer. Pien Tze Huang (PZH), a well-known traditional Chinese formulation that was first prescribed 450 years ago, has long been used as an alternative remedy for cancers. However, the precise mechanism of PZH's anticancer activity remains to be further elucidated. Using a colorectal cancer mouse xenograft model, in the present study, we evaluated the effect of PZH on tumor angiogenesis and investigated the underlying molecular mechanisms. We found that PZH inhibited tumor growth since PZH treatment resulted in decrease in both tumor volume and tumor weight in CRC mice. In addition, PZH suppressed the activation of several signaling pathways such as STAT3, Akt and MAPKs. Consequently, the inhibitory effect of PZH on these pathways resulted in the inhibition of tumor angiogenesis as demonstrated by the decrease of microvessel density in tumor tissues. Moreover, PZH treatment reduced the expression of angiogenic factors including iNOS, eNOS, VEGF-A, bFGF as well as their specific receptors VEGFR2 and bFGFR. Altogether, our findings suggest that inhibition of tumor angiogenesis via suppression of multiple signaling pathways might be one of the mechanisms whereby PZH affects cancers. PMID:23843018

  8. Pien Tze Huang Overcomes Multidrug Resistance and Epithelial-Mesenchymal Transition in Human Colorectal Carcinoma Cells via Suppression of TGF-β Pathway

    PubMed Central

    Shen, Aling; Chen, Hongwei; Chen, Youqin; Lin, Wei; Liu, Liya; Sferra, Thomas J.; Peng, Jun

    2014-01-01

    The traditional Chinese medicine formula Pien Tze Huang (PZH) has long been used as a folk remedy for cancer. To elucidate the mode of action of PZH against cancer, in the present study we used a 5-FU resistant human colorectal carcinoma cell line (HCT-8/5-FU) to evaluate the effects of PZH on multidrug resistance (MDR) and epithelial-mesenchymal transition (EMT) as well as the activation of TGF-β pathway. We found that PZH dose-dependently inhibited the viability of HCT-8/5-FU cells which were insensitive to treatment of 5-FU and ADM, demonstrating the ability of PZH to overcome chemoresistance. Furthermore, PZH increased the intercellular accumulation of Rhodamine-123 and downregulated the expression of ABCG2 in HCT-8/5-FU cells. In addition, drug resistance induced the process of EMT in HCT-8 cells as evidenced by EMT-related morphological changes and alteration in the expression of EMT-regulatory factors, which however was neutralized by PZH treatment. Moreover, PZH inhibited MDR/EMT-enhanced migration and invasion capabilities of HCT-8 cells in a dose-dependent manner and suppressed MDR-induced activation of TGF-β signaling in HCT-8/5-FU cells. Taken together, our study suggests that PZH can effectively overcome MDR and inhibit EMT in human colorectal carcinoma cells via suppression of the TGF-β pathway. PMID:25505925

  9. Pien Tze Huang suppresses IL-6-inducible STAT3 activation in human colon carcinoma cells through induction of SOCS3.

    PubMed

    Shen, Aling; Chen, Youqin; Hong, Fei; Lin, Jiumao; Wei, Lihui; Hong, Zhenfeng; Sferra, Thomas J; Peng, Jun

    2012-12-01

    IL-6/STAT3 is one of the most critical cellular signal transduction pathways known to malfunction in colorectal cancer (CRC). As a target gene of signal transducer and activator of transcription 3 (STAT3) signaling, suppressor of cytokine signaling 3 (SOCS3) can be quickly induced by interleukin-6 (IL-6) stimulation but it then strongly inhibits IL-6-mediated STAT3 activation, functioning as a negative feedback regulator of the IL-6/STAT3 pathway. Aberrant activation of STAT3 and/or reduced expression of SOCS are strongly correlated with carcinogenesis, which therefore becomes a promising target for the development of novel anticancer chemotherapies. Pien Tze Huang (PZH) is a well-known traditional Chinese formula that was first prescribed by a royal physician 450 years ago in the Ming Dynasty. It has been used in China and Southeast Asia for centuries as a folk remedy for various types of cancer including CRC. However, the precise mechanism of its antitumor activity remains largely unclear. In the present study, we found that PZH could significantly and dose-dependently inhibit IL-6-mediated increase of STAT3 phosphorylation levels and transcriptional activity in the human colon carcinoma HT-29 cells, resulting in the suppression of cell proliferation and the induction of apoptosis. In addition, PZH treatment profoundly inhibited IL-6-induced upregulation of cyclin D1 and Bcl-2, two key target genes of the STAT3 pathway. Moreover, PZH treatment increased the expression of SOCS3. These results suggest that PZH could effectively inhibit proliferation and promote apoptosis of human colon carcinoma cells via modulation of the IL-6/STAT3 signaling pathway and its target genes. PMID:23027374

  10. Pien Tze Huang inhibits tumor cell proliferation and promotes apoptosis via suppressing the STAT3 pathway in a colorectal cancer mouse model.

    PubMed

    Zhuang, Qunchuan; Hong, Fei; Shen, Aling; Zheng, Liangpu; Zeng, Jianwei; Lin, Wei; Chen, Youqin; Sferra, Thomas J; Hong, Zhenfeng; Peng, Jun

    2012-05-01

    Signal transducer and activator of transcription 3 (STAT3) plays a critical role in cell survival and proliferation. Constitutive activation of STAT3 is strongly correlated with pathogenesis of various types of malignant tumors including colorectal cancer (CRC), and therefore is a major focus in the development of anti-cancer agents. Pien Tze Huang (PZH), a well-known traditional Chinese formula prescribed already in the Ming Dynasty, has been demonstrated to be clinically effective in the treatment of CRC. However, the precise mechanism of its anti-cancer activity remains largely unknown. In the present study we evaluated the efficacy of PZH against tumor growth in vivo in the CRC mouse xenograft model, and investigated the underlying molecular mechanisms. We found that administration of PZH reduced tumor volume and tumor weight but had no effect on body weight gain in CRC mice, demonstrating that PZH can inhibit colon cancer growth in vivo without apparent adverse effect. We also observed that PZH treatment inhibited the phosphorylation level of STAT3 in tumor tissues. Consequently, the inhibitory effect of PZH on STAT3 activation resulted in the up-regulation of Bax/Bcl-2 ratio as well as down-regulation of Cyclin D1 and CDK4 expression, leading to the induction of apoptosis as well as the inhibition of cell proliferation. These results suggest that promotion of cancer cell apoptosis and inhibition of proliferation via suppression of STAT3 pathway might be one of the mechanisms by which PZH treats colorectal cancer. PMID:22218594

  11. Pien Tze Huang protects the liver against carbon tetrachloride-induced damage.

    PubMed

    Lee, Kenneth K H; Kwong, Wing Hang; Chau, Foo-tim; Yew, David T; Chan, Wood Yee

    2002-10-01

    Pien Tze Huang, a traditional Chinese medicine, has been extensively used as a therapeutic drug in the treatment of liver diseases. In this study, we have examined its ability to protect the liver from carbon tetrachloride (CCl4)-induced damage in the mouse. Histological observations revealed that CCl4 treatment induced extensive degenerative changes in the hepatocytes surrounding the central veins of the liver. However, these changes were much reduced by more than 28% in mice fed with 0.5 mg of Pien Tze Huang/g body weight/dose (3 doses over 36 hr) prior to CCl4 treatment. The effects of Pien Tze Huang were then further investigated in a hepatoma cell line. Flow analysis showed that it had no significant effects on cell proliferation. When the ability of Pien Tze Huang to influence various response elements of important signal transduction pathways was examined in the hepatoma cell line, it was found that Pien Tze Huang stimulated an increase in the response of AP1, CRE and NFkappaB responsive elements. The transcriptional factors of these responsive elements are known to play important roles in regulating cell death and survival. We thus postulate that the ability of Pien Tze Huang to protect the liver from damage is attained through its ability to modulate the activity of these important signal transduction pathways. PMID:12530469

  12. Substitution for natural musk in Pien Tze Huang does not affect its hepatoprotective activities.

    PubMed

    Chan, W Y; Chau, F T; Lee, K K H; Kwong, W H; Yew, D T

    2004-01-01

    Previous studies showed that Pien Tze Huang, a Chinese folk medicine well known for its therapeutic activity in treating liver diseases, protected the liver against carbon tetrachloride (CCl4)-induced damage in mice. In the present study, natural musk, one of the important ingredients of Pien Tze Huang, was replaced by a formulated substitute, and the new formulation of Pien Tze Huang was shown to have similar chromatographic patterns to the original Pien Tze Huang in gas chromatography-mass spectrometry and high performance liquid chromatography. When used in treating mice with CCl4- or galactosamine-induced liver damage, both the original and new formulations of Pien Tze Huang were found to be able to suppress to a similar extent both the histopathological changes in the liver and the elevation of serum alanine aminotransferase and aspartate aminotransferase. Necrosis, cellular ballooning, microvesicular steatosis and lymphocytes infiltration were all significantly reduced in the damaged liver. In hepatoma cells, both formulations activated the activator protein 1 (AP1) enhancer sequence, indicating that both of them were able to act through the JNK signal transduction pathway. The results of the present study showed that the substitution for natural musk does not affect the hepatoprotective activities of Pien Tze Huang. It is also postulated that both formulations protect the liver through regulating signal transduction in the cell. PMID:15027814

  13. Rapid simultaneous determination of twelve major components in Pien Tze Huang by ultra-performance liquid chromatography coupled with triple quadrupole mass spectrometry.

    PubMed

    Huang, Mingqing; Zhao, Haiyu; Xu, Wei; Chu, Kedan; Hong, Zhenfeng; Peng, Jun; Chen, Lidian

    2013-12-01

    An efficient method using ultra-performance LC coupled with triple quadrupole MS was developed for the rapid determination of 12 major active components in Pien Tze Huang (PZH), a well-known traditional Chinese formula. Chromatographic separation was achieved on a Waters XBridge BEH RP18 column (50 mm × 2.1 mm id, 1.7 μm) with a gradient mobile phase (A: 0.1% aqueous formic acid and B: acetonitrile with 0.1% formic acid) at a flow rate of 0.8 mL/min. The chromatographic peaks of 12 components were identified by comparing their retention time and MS data with the related reference compounds. Multiple-reaction monitoring was employed for the quantitative analysis. Ten batches of PZH were analyzed with a good linear regression relationship (r, 0.9987–0.9995), intraday precisions (RSD, 2.05–4.80%), interday precisions (RSD, 1.99–4.98%), repeatability (RSD, 2.21–4.20%), stability (RSD, 3.52–4.81%), and recovery (95.63–104.80%). By using this established method, the present study offered highly sensitive, specific, and speedy determination of 12 major components, which promoted the quality control investigation of PZH greatly. PMID:24151031

  14. [Textual research on Huang shinüke (Huang's Obstetrics and Gynecology)].

    PubMed

    Wen, Jianfang; Wu, Tong

    2015-07-01

    Huang shi nü ke (Huang's Obstetrics and Gynecology), a handwritten copy of the Ming Dynasty passed on by Huang Xiaoyou, Yuanyi and Huang Dongjiu, and sorted out by Huang Yanrong, was a family medical book of Huang's obstetrics and gynecology in Xin'an, being a summary of their clinical experience.There were altogether 44 chapters divided into 4 parts, including general introduction, general principle of treatment, discussions on prenatal conditions and qi acquired from the mother, and gynecological diseases in sequence, with the appendixes of pulse diagnostics for differentiating male and female, and the 10-month methods of protecting the fetus. PMID:26815029

  15. Hilbert-Huang Transform in Ocean Turbulence

    NASA Astrophysics Data System (ADS)

    Huang, Yongxiang

    2013-04-01

    Hilbert-Huang Transform is a relative novel time-frequency analysis technique for multi-scale processes. It is a wavelet-like data-driven methodology without a priori basis assumption. This meets the requirement of the analysis of the nonstationary and nonlinear data with short length or irregular sampling time interval. Since it is introduced in 1998 by Dr. N.E Huang, it has been widely applied to different scientific research fields and engineering problems, showing its simplicity and successes. We develop further this method to characterize the scale invariance for turbulence-like/scaling processes, e.g., velocity, temperature, dissolved oxygen observed in ocean, etc. In this talk, we first present a general introduction of this method. The key feature of this Hilbert-based method is that it is free with sub-harmonics when dealing with nonstationary and nonlinear data. This is accomplished by using an Intrawave-Frequency Modulation mechanism to characterize the so-called nonlinear distortion. Therefore, unlike the Fourier based methodologies, artificial energy redistribution in spectral space is constrained. We then show several applications of this method to experimental data from wind tunnel experiments and ocean observations. The interaction between two different scales and two variables are also discussed in statistics sense. The method is general and applicable to other systems, in which the multi-scale is relevant. Reference 1. Huang, N. E.; Shen, Z.; Long, S. R.; Wu, M. C.; Shih, H. H.; Zheng, Q.; Yen, N.; Tung, C. C. & Liu, H. H. The empirical mode decomposition and the Hilbert spectrum for nonlinear and non-stationary time series analysis Proc. R. Soc. London, Ser. A, Royal Society, 1998, 454, 903-995 2. Huang, Y.; Schmitt, F.; Lu, Z. & Liu, Y. An amplitude-frequency study of turbulent scaling intermittency using Hilbert spectral analysis, Europhys. Lett., 2008, 84, 40010 3. Huang, Y.; Schmitt, F.; Lu, Z.; Fougairolles, P.; Gagne, Y. & Liu, Y. Second-order structure function in fully developed turbulence Phys. Rev. E, American Physical Society, 2010, 82, 26319 4. Huang, Y.; Schmitt, F. G.; Hermand, J.-P.; Gagne, Y.; Lu, Z. & Liu, Y. Arbitrary-order Hilbert spectral analysis for time series possessing scaling statistics: comparison study with detrended fluctuation analysis and wavelet leaders Phys. Rev. E, 2011, 84, 016208

  16. Hot-electron relaxation in metals within the Götze-Wölfle memory function formalism

    NASA Astrophysics Data System (ADS)

    Das, Nabyendu; Singh, Navinder

    2016-04-01

    We consider nonequilibrium relaxation of electrons due to their coupling with phonons in a simple metal. In our model, electrons are living at a higher temperature than that of the phonon bath, mimicking a nonequilibrium steady-state situation. We study the relaxation of such hot electrons proposing a suitable generalization of the memory function formalism formulated by Götze and Wölfle (GW) [W. Götze and P. Wölfle, Phys. Rev. B 6, 1226 (1972)]. We derive analytical expressions for both the DC or zero frequency scattering rates and the optical scattering rates in various temperature and frequency regimes. Limiting cases are in accord with the previous studies. An interesting feature that the DC scattering rate at high temperatures and optical scattering rate at high frequencies are independent of the temperature difference between the electrons and the phonons is found in this study. The present formalism forms a basis which can also be extended to study hot-electron relaxation in variety of complex materials.

  17. The Application of Hilbert-Huang Transforms to Meteorological Datasets

    NASA Technical Reports Server (NTRS)

    Duffy, Dean G.

    2003-01-01

    Recently a new spectral technique as been developed for the analysis of aperiodic and nonlinear signals - the Hilbert-Huang transform. This paper shows how these transforms can be used to discover synoptic and climatic features: For sea level data, the transforms capture the oceanic tides as well as large, aperiodic river outflows. In the case of solar radiation, we observe variations in the diurnal and seasonal cycles. Finally, from barographic data, the Hilbert-Huang transform reveals the passage of extratropical cyclones, fronts, and troughs. Thus, this technique can flag significant weather events such its a flood or the passage of a squall line.

  18. Neuroprotective Effect of Gui Zhi (Ramulus Cinnamomi) on Ma Huang- (Herb Ephedra-) Induced Toxicity in Rats Treated with a Ma Huang-Gui Zhi Herb Pair

    PubMed Central

    Zheng, Fang-hao; Wei, Ping; Huo, Hui-ling; Xing, Xue-feng; Chen, Fei-long; Tan, Xiao-mei; Luo, Jia-bo

    2015-01-01

    Herb Ephedra (Ma Huang in Chinese) and Ramulus Cinnamomi (Gui Zhi in Chinese) are traditional Chinese herbs, often used together to treat asthma, nose and lung congestion, and fever with anhidrosis. Due to the adverse effects of ephedrine, clinical use of Ma Huang is restricted. However, Gui Zhi extract has been reported to decrease spontaneous activity in rats and exert anti-inflammatory and neuroprotective effects. The present study explored the possible inhibitory effect of Gui Zhi on Ma Huang-induced neurotoxicity in rats when the two herbs were used in combination. All Ma Huang and Ma Huang-Gui Zhi herb pair extracts were prepared using methods of traditional Chinese medicine and were normalized based on the ephedrine content. Two-month-old male Sprague-Dawley rats (n = 6 rats/group) were administered Ma Huang or the Ma Huang-Gui Zhi herb pair extracts for 7 days (ephedrine = 48 mg/kg), and locomotor activity was measured. After 7 days, oxidative damage in the prefrontal cortex was measured. Gui Zhi decreased hyperactivity and sensitization produced by repeated Ma Huang administration and attenuated oxidative stress induced by Ma Huang. The results of this study demonstrate the neuroprotective potential of Gui Zhi in Ma Huang-induced hyperactivity and oxidative damage in the prefrontal cortex of rats when used in combination. PMID:25691910

  19. Neuroprotective effect of gui zhi (ramulus cinnamomi) on ma huang- (herb ephedra-) induced toxicity in rats treated with a ma huang-gui zhi herb pair.

    PubMed

    Zheng, Fang-Hao; Wei, Ping; Huo, Hui-Ling; Xing, Xue-Feng; Chen, Fei-Long; Tan, Xiao-Mei; Luo, Jia-Bo

    2015-01-01

    Herb Ephedra (Ma Huang in Chinese) and Ramulus Cinnamomi (Gui Zhi in Chinese) are traditional Chinese herbs, often used together to treat asthma, nose and lung congestion, and fever with anhidrosis. Due to the adverse effects of ephedrine, clinical use of Ma Huang is restricted. However, Gui Zhi extract has been reported to decrease spontaneous activity in rats and exert anti-inflammatory and neuroprotective effects. The present study explored the possible inhibitory effect of Gui Zhi on Ma Huang-induced neurotoxicity in rats when the two herbs were used in combination. All Ma Huang and Ma Huang-Gui Zhi herb pair extracts were prepared using methods of traditional Chinese medicine and were normalized based on the ephedrine content. Two-month-old male Sprague-Dawley rats (n = 6 rats/group) were administered Ma Huang or the Ma Huang-Gui Zhi herb pair extracts for 7 days (ephedrine = 48?mg/kg), and locomotor activity was measured. After 7 days, oxidative damage in the prefrontal cortex was measured. Gui Zhi decreased hyperactivity and sensitization produced by repeated Ma Huang administration and attenuated oxidative stress induced by Ma Huang. The results of this study demonstrate the neuroprotective potential of Gui Zhi in Ma Huang-induced hyperactivity and oxidative damage in the prefrontal cortex of rats when used in combination. PMID:25691910

  20. Aeroelastic Flight Data Analysis with the Hilbert-Huang Algorithm

    NASA Technical Reports Server (NTRS)

    Brenner, Martin J.; Prazenica, Chad

    2006-01-01

    This report investigates the utility of the Hilbert Huang transform for the analysis of aeroelastic flight data. It is well known that the classical Hilbert transform can be used for time-frequency analysis of functions or signals. Unfortunately, the Hilbert transform can only be effectively applied to an extremely small class of signals, namely those that are characterized by a single frequency component at any instant in time. The recently-developed Hilbert Huang algorithm addresses the limitations of the classical Hilbert transform through a process known as empirical mode decomposition. Using this approach, the data is filtered into a series of intrinsic mode functions, each of which admits a well-behaved Hilbert transform. In this manner, the Hilbert Huang algorithm affords time-frequency analysis of a large class of signals. This powerful tool has been applied in the analysis of scientific data, structural system identification, mechanical system fault detection, and even image processing. The purpose of this report is to demonstrate the potential applications of the Hilbert Huang algorithm for the analysis of aeroelastic systems, with improvements such as localized online processing. Applications for correlations between system input and output, and amongst output sensors, are discussed to characterize the time-varying amplitude and frequency correlations present in the various components of multiple data channels. Online stability analyses and modal identification are also presented. Examples are given using aeroelastic test data from the F-18 Active Aeroelastic Wing airplane, an Aerostructures Test Wing, and pitch plunge simulation.

  1. Application of Huang-Hilbert Transforms to Geophysical Datasets

    NASA Technical Reports Server (NTRS)

    Duffy, Dean G.

    2003-01-01

    The Huang-Hilbert transform is a promising new method for analyzing nonstationary and nonlinear datasets. In this talk I will apply this technique to several important geophysical datasets. To understand the strengths and weaknesses of this method, multi- year, hourly datasets of the sea level heights and solar radiation will be analyzed. Then we will apply this transform to the analysis of gravity waves observed in a mesoscale observational net.

  2. Aeroelastic Flight Data Analysis with the Hilbert-Huang Algorithm

    NASA Technical Reports Server (NTRS)

    Brenner, Marty; Prazenica, Chad

    2005-01-01

    This paper investigates the utility of the Hilbert-Huang transform for the analysis of aeroelastic flight data. It is well known that the classical Hilbert transform can be used for time-frequency analysis of functions or signals. Unfortunately, the Hilbert transform can only be effectively applied to an extremely small class of signals, namely those that are characterized by a single frequency component at any instant in time. The recently-developed Hilbert-Huang algorithm addresses the limitations of the classical Hilbert transform through a process known as empirical mode decomposition. Using this approach, the data is filtered into a series of intrinsic mode functions, each of which admits a well-behaved Hilbert transform. In this manner, the Hilbert-Huang algorithm affords time-frequency analysis of a large class of signals. This powerful tool has been applied in the analysis of scientific data, structural system identification, mechanical system fault detection, and even image processing. The purpose of this paper is to demonstrate the potential applications of the Hilbert-Huang algorithm for the analysis of aeroelastic systems, with improvements such as localized/online processing. Applications for correlations between system input and output, and amongst output sensors, are discussed to characterize the time-varying amplitude and frequency correlations present in the various components of multiple data channels. Online stability analyses and modal identification are also presented. Examples are given using aeroelastic test data from the F/A-18 Active Aeroelastic Wing aircraft, an Aerostructures Test Wing, and pitch-plunge simulation.

  3. On the Hilbert-Huang Transform Theoretical Foundation

    NASA Technical Reports Server (NTRS)

    Kizhner, Semion; Blank, Karin; Huang, Norden E.

    2004-01-01

    The Hilbert-Huang Transform [HHT] is a novel empirical method for spectrum analysis of non-linear and non-stationary signals. The HHT is a recent development and much remains to be done to establish the theoretical foundation of the HHT algorithms. This paper develops the theoretical foundation for the convergence of the HHT sifting algorithm and it proves that the finest spectrum scale will always be the first generated by the HHT Empirical Mode Decomposition (EMD) algorithm. The theoretical foundation for cutting an extrema data points set into two parts is also developed. This then allows parallel signal processing for the HHT computationally complex sifting algorithm and its optimization in hardware.

  4. Hilbert-Huang Transform and Scaling Analysis of Various Geoscience data

    NASA Astrophysics Data System (ADS)

    Schmitt, Francois; Huang, Yongxiang

    2014-05-01

    In geoscience, the field observation data are always nonlinear and nonstationary. They are also showing multiscale property since different spatial and temporal scales are involved. It is found that traditional methodologies, e.g., Fourier spectral analysis, structure-function analysis, etc., are strongly influenced by either nonlinear or nonstationary events. The Hilbert-Huang Transform (the combination of Empirical Mode Decomposition and Hilbert Spectral analysis) is efficient to handle both the nonlinearity and nonstationarity. In this talk, we apply this Hilbert-based methodology to various geoscience data collected from different field observations to characterize their scaling property. The collected data are daily river discharge, sea level, copepod abundance, wind energy, environmental data (temperature, dissolved oxygen) from coastal line, etc. Scaling property of these processes are then characterized in the frame of Hilbert spectral analysis. Reference 1. Huang Y, Schmitt F, Lu Z and Liu Y 2008 Europhys. Lett. 84, 40010. 2. Huang Y, Schmitt F, Lu Z and Liu Y 2009 J. Hydrol. 373, 103-111. 3. Schmitt F.G., Huang Y., Lu, Z., Liu Y., and Fernandez N. J. Mar. Sys., 2009, 77, 473-481 4. Schmitt F. G., Huang Y., Lu, Z., Zongo S. B., Molinero J. C. and Liu Y. Nonlinear Dynamics in Geosciences. edited by A. Tsonis and J. Elsner, Springer, 2007, 261-280 5. Huang Y. and Schmitt F. G. J. Mar. Sys., 2014, 130, 90-100 6. Calif R., Schmitt F. G. and Huang, Y. Physica A, 2013, 392, 4106-4120

  5. Application of the Hilbert-Huang Transform to Financial Data

    NASA Technical Reports Server (NTRS)

    Huang, Norden

    2005-01-01

    A paper discusses the application of the Hilbert-Huang transform (HHT) method to time-series financial-market data. The method was described, variously without and with the HHT name, in several prior NASA Tech Briefs articles and supporting documents. To recapitulate: The method is especially suitable for analyzing time-series data that represent nonstationary and nonlinear phenomena including physical phenomena and, in the present case, financial-market processes. The method involves the empirical mode decomposition (EMD), in which a complicated signal is decomposed into a finite number of functions, called "intrinsic mode functions" (IMFs), that admit well-behaved Hilbert transforms. The HHT consists of the combination of EMD and Hilbert spectral analysis. The local energies and the instantaneous frequencies derived from the IMFs through Hilbert transforms can be used to construct an energy-frequency-time distribution, denoted a Hilbert spectrum. The instant paper begins with a discussion of prior approaches to quantification of market volatility, summarizes the HHT method, then describes the application of the method in performing time-frequency analysis of mortgage-market data from the years 1972 through 2000. Filtering by use of the EMD is shown to be useful for quantifying market volatility.

  6. Identification of Velcro rales based on Hilbert-Huang transform

    NASA Astrophysics Data System (ADS)

    Chen, Xue; Shao, Jie; Long, Yingjiao; Que, Chengli; Zhang, Jue; Fang, Jing

    2014-05-01

    Velcro rales, as a kind of crackles, are relatively specific for lung fibrosis and usually the first clinical clue of interstitial lung disease (ILD). We proposed an automatic analytic tool based on Hilbert-Huang transform (HHT) for the computerized identification of Velcro rales. In particular, HHT was utilized to extract the energy weight in various frequency bands (EW) of crackles and to calculate the portion of crackles during late inspiration. Support vector machine (SVM) based on the HHT-derived measures was used to differentiate Velcro rales from other crackles. We found that there were significant differences in the extracted parameters between Velcro rales and other crackles, including EW, EW and the proportion of crackles that appeared during the late inspiration. The discrimination results obtained from SVM achieved a concordance rate up to 92.20%±1.80% as confirmed by the diagnosis from experienced physicians. For practical purpose, the proposed approach may have potential applications to improve the sensitivity and accuracy of auscultation and conduct automatic ILD diagnose system.

  7. Effect of Rhizoma coptidis (Huang Lian) on Treating Diabetes Mellitus

    PubMed Central

    Pang, Bing; Yu, Xiao-Tong; Zhou, Qiang; Zhao, Tian-Yu; Wang, Han; Gu, Cheng-Juan; Tong, Xiao-Lin

    2015-01-01

    The rapidly increasing diabetes mellitus (DM) is becoming a major public health issue globally; considerable progress has been made in the field of western hypoglycemic drug and insulin, but some shortages still exist. As one of the most important parts in complementary and alternative therapies, traditional Chinese medicine (TCM) performs a good clinical practice and is showing a bright future in the treatment of DM. TCM therapy has certain advantages of less toxicity and/or side effects, and Chinese herbal medicine which usually contains various active ingredients could provide multiple therapeutic effects. Huang Lian (Rhizoma coptidis, RC) is a herb frequently used in many traditional formulas for properties of “clearing damp-heat, quenching fire, and counteracting poison” in Asia for centuries. In this review, we summarize the application of RC in the treatment of DM from two aspects of contents. Firstly, theoretical principles are explained, including the properties and related records about RC in ancient references and modern pharmacological researches and pharmacokinetics on RC and its active components. Secondly, the clinical application of RC is mainly reviewed, such as applicable stage and syndrome, the reasonable dose range, the preparation formulations, and the toxicity and/or side effects and solutions to its adverse actions. This review provides scientific evidence about the effective components, pharmacological researches, and toxicity of RC, as well as introducing traditional Chinese medical theory and clinical experience, in order to guide clinician to use RC more suitably and reasonably in the clinical practice. PMID:26508987

  8. Hilbert-Huang transformation-based time-frequency analysis methods in biomedical signal applications.

    PubMed

    Lin, Chin-Feng; Zhu, Jin-De

    2012-03-01

    Hilbert-Huang transformation, wavelet transformation, and Fourier transformation are the principal time-frequency analysis methods. These transformations can be used to discuss the frequency characteristics of linear and stationary signals, the time-frequency features of linear and non-stationary signals, the time-frequency features of non-linear and non-stationary signals, respectively. The Hilbert-Huang transformation is a combination of empirical mode decomposition and Hilbert spectral analysis. The empirical mode decomposition uses the characteristics of signals to adaptively decompose them to several intrinsic mode functions. Hilbert transforms are then used to transform the intrinsic mode functions into instantaneous frequencies, to obtain the signal's time-frequency-energy distributions and features. Hilbert-Huang transformation-based time-frequency analysis can be applied to natural physical signals such as earthquake waves, winds, ocean acoustic signals, mechanical diagnosis signals, and biomedical signals. In previous studies, we examined Hilbert-Huang transformation-based time-frequency analysis of the electroencephalogram FPI signals of clinical alcoholics, and 'sharp I' wave-based Hilbert-Huang transformation time-frequency features. In this paper, we discuss the application of Hilbert-Huang transformation-based time-frequency analysis to biomedical signals, such as electroencephalogram, electrocardiogram signals, electrogastrogram recordings, and speech signals. PMID:22558835

  9. On the Hilbert-Huang Transform Data Processing System Development

    NASA Technical Reports Server (NTRS)

    Kizhner, Semion; Flatley, Thomas P.; Huang, Norden E.; Cornwell, Evette; Smith, Darell

    2003-01-01

    One of the main heritage tools used in scientific and engineering data spectrum analysis is the Fourier Integral Transform and its high performance digital equivalent - the Fast Fourier Transform (FFT). The Fourier view of nonlinear mechanics that had existed for a long time, and the associated FFT (fairly recent development), carry strong a-priori assumptions about the source data, such as linearity and of being stationary. Natural phenomena measurements are essentially nonlinear and nonstationary. A very recent development at the National Aeronautics and Space Administration (NASA) Goddard Space Flight Center (GSFC), known as the Hilbert-Huang Transform (HHT) proposes a novel approach to the solution for the nonlinear class of spectrum analysis problems. Using the Empirical Mode Decomposition (EMD) followed by the Hilbert Transform of the empirical decomposition data (HT), the HHT allows spectrum analysis of nonlinear and nonstationary data by using an engineering a-posteriori data processing, based on the EMD algorithm. This results in a non-constrained decomposition of a source real value data vector into a finite set of Intrinsic Mode Functions (IMF) that can be further analyzed for spectrum interpretation by the classical Hilbert Transform. This paper describes phase one of the development of a new engineering tool, the HHT Data Processing System (HHTDPS). The HHTDPS allows applying the "T to a data vector in a fashion similar to the heritage FFT. It is a generic, low cost, high performance personal computer (PC) based system that implements the HHT computational algorithms in a user friendly, file driven environment. This paper also presents a quantitative analysis for a complex waveform data sample, a summary of technology commercialization efforts and the lessons learned from this new technology development.

  10. Fault pattern and oil migration in Huang Hua depression, China

    SciTech Connect

    Zhou, Guojun )

    1994-08-01

    Huang Hua depression is a back-arc intercratonic rift basin that developed on the north China platform in the Cenozoic. Controlled by the basement anisotropy, multidirectional fault sets on the plane are developed along the preexisting zone of weakness. According to the scale of tectonic elements controlled by faults, as well as its time of activity and depth, normal faults are divided into four grades in this basin. Seismic data and geological information have shown that 70% of the faults are listric faults. Flattening of the faults reflect tilting of fault block or detachment along the unconformity surfaces and ductile beds. Because of gravity creep and local extension main faults and secondary faults are united into a [open quotes]horse tail[close quotes] or [open quotes]Y[close quotes] patterns. Results of oil-source rock correlation and oil migration parameters all demonstrate that oil and gas migrate in or through faults (fracture zones), and form the [open quotes]step-like[close quotes] migration model. Faults in sandstone-shale sequences play the role of conduits for hydrocarbon, but faults in gypsum beds and thick undercompacted shales generally act as a top seal. To prevent oil migration through faults, reservoirs and ductile rocks with a high capillary displacement pressure must be juxtaposed. Whether faults are rejuvenated during hydrocarbon migration is not required for faults opening, but it is important to investigate the activity history of growth faults and the role of juxtaposed sediments in a sandstone-shale sequence in creating sealing and nonsealing faults.

  11. Cardiotoxicity of Ma Huang/caffeine or ephedrine/caffeine in a rodent model system.

    PubMed

    Dunnick, J K; Kissling, G; Gerken, D K; Vallant, M A; Nyska, A

    2007-08-01

    Ma Huang (equivalent to 0, 12.5, 25, or 50 mg/kg ephedrine) or ephedrine (0, 6.25, 12.5, 25 mg/kg) were administered as one bolus oral dose to male F344 rats with and without caffeine. The herbal medicine Ma Huang (ephedra) in combination with caffeine caused rapid clinical signs of toxicity including salivation, hyperactivity, ataxia, and eventually lethargy, and failure to respond to stimuli. When this syndrome of clinical signs emerged, animals were moribund sacrificed, and a histological analysis for heart lesions performed. Cardiotoxicity included hemorrhage, necrosis, and degeneration in the ventricles or interventricular septum within 2-4 hours after treatment with Ma Huang (ephedra)/caffeine or ephedrine (the principal active component in Ma Huang)/caffeine. There was a steep dose response curve for cardiotoxicity with minimal toxicity seen at levels of Ma Huang (equivalent to 12.5 mg/kg ephedrine) with caffeine. However, cardiotoxic lesions occurred in 28% of animals with Ma Huang dosages equivalent to 25 mg/kg ephedrine with 15 or 30 mg/kg caffeine, and in 90% of animals at Ma Huang exposures equivalent to 50 mg/kg ephedrine with 15 or 30 mg/kg caffeine. Cardiotoxic lesions occurred in 47% of animals in the 25 mg/kg ephedrine groups with caffeine at 7.25, 15, or 30 mg/kg. There was no statistical difference in the occurrence of cardiotoxic lesions when 15 or 30 mg/kg caffeine was combined with Ma Huang equivalent to 25 or 50 mg/kg ephedrine; likewise there was no statistical difference in the occurrence of cardiotoxic lesions when 7.25, 15, or 30 mg/kg caffeine was combined with 25 mg/kg ephedrine. These results show that the cardiotoxic effects of the herbal medicine, Ma Huang, are similar to that of ephedrine, the principal active ingredient in the herbal medicine. The combination of Ma Huang or ephedrine with caffeine enhanced the cardiotoxicity over that with the herbal medicine or the active ingredient alone. PMID:17676524

  12. [Research progress on Huang Fu-mi's A-B classic of acupuncture and moxibustion].

    PubMed

    Tian, Bing-kun; Xing, Yu-rui

    2014-11-01

    In order to understand the research status of HUANG Fu-mi's A-B Classic of Acupuncture and Moxibustion, 83 pieces of literature that have been publically published since 1978 were analyzed. A summary was performed according to 7 aspects including version origin, emendation, arrangement and summary, theory discussion, clinical research, value evaluation, the rest questions, etc. It is believed that deep research work has been done on explanations, emendation and translation regarding A-B Classic of Acupuncture and Moxibustion. However, the exploration work on the theory and application is far from enough. Therefore, beginning from historical and cultural background, we should analyze the humanistic spirit of HUANG Fu-mi combined with A-B Classic of Acupuncture and Moxibustion to perform a deep exploration, so we could have a thorough and comprehensive research on HUANG Fu-mi's academic thoughts. PMID:25675584

  13. Temporal and spatial variability of drought in Huang-Huai-Hai River Basin, China

    NASA Astrophysics Data System (ADS)

    Yuan, Zhe; Yan, Deng-Hua; Yang, Zhi-Yong; Yin, Jun; Yuan, Yong

    2015-11-01

    Drought is a kind of extreme hydrological event. With the penetration of climate change impact, severity, areal extent, and frequency of drought are increasing, especially in Huang-Huai-Hai River Basin, which plays a key role in China's agriculture production. Analyzing the regional temporal and spatial variability in the context of climate change could provide a basis for the evasion of disasters and risk. The maximum number of consecutive dry days was selected as the indicator to analyze the decadal variability of drought severity, areal extent, and spatial variability of drought frequency in different seasons in Huang-Huai-Hai River Basin. Based on these, temporal and spatial variability of two kinds of special extreme events—consecutive drought and heavy rain after drought—were studied. The results showed that: (1) Huang-Huai-Hai River Basin mainly experienced moderate drought and severe drought. Moderate drought mainly occurs in autumn. High-frequency region of moderate drought is located in the plain of Huang-Huai-Hai River Basin, and its area is approximately 22.7 % of Huang-Huai-Hai River Basin. Severe drought often occurs in spring with high-frequency region in the upstream of the Yellow River. The area of this high-frequency region is about 6 % of Huang-Huai-Hai River Basin. (2) During 1961~2011, the areal extent of summer severe drought, autumn severe drought, and extreme drought all showed increasing trend, in which the increasing trend of the autumn severe drought area in the Yellow River has reached the significance level α = 0.05. (3) Consecutive drought of several seasons often took place in Ningxia plain and Hetao plain which lie in the northwest of the Yellow River Basin. In the recent 20 years, consecutive drought from spring to summer and consecutive drought from summer to autumn occurred frequently. Drought-flood abrupt alternation such as heavy rain after drought often occurred in summer temporally and Huaihe River Basin spatially.

  14. [Birthplace of the Qi-Huang culture-Xinmi of the Henan Province].

    PubMed

    Yang, Jian-Min

    2012-05-01

    Located in the central plains and the eastern slope of songhsan, Xinmi has a long history and unique advantage in environment. As the birthplace of Qi-Huang culture, it has abundant Qibo and Huangdi relics (Xuanyuan tpe, Qibo tomb, Qibo temple, Qibo spring, Huangdi palace and Qibo mountain), folk tales about their academic discussion which were popular long time ago, many archaeological discoveries with academic value and genuine Chinese medicinal materials. Qi-Huang culture is the valuable Chinese culture heritage and it needs to be further studied and developed. PMID:22883381

  15. The Value of SCMC in SLA: Comments on Lin, Huang & Liou (2013)

    ERIC Educational Resources Information Center

    Taylor, Alan M.

    2014-01-01

    Meta-analytic methods are often used to determine the effectiveness of certain treatments across studies. However, we are often unaware of how a meta-analysis can provide value to researchers and practitioners. This paper offers a brief commentary on a meta-analysis conducted by Lin, Huang and Liou (2013) in LLT, providing further statistical

  16. The Value of SCMC in SLA: Comments on Lin, Huang & Liou (2013)

    ERIC Educational Resources Information Center

    Taylor, Alan M.

    2014-01-01

    Meta-analytic methods are often used to determine the effectiveness of certain treatments across studies. However, we are often unaware of how a meta-analysis can provide value to researchers and practitioners. This paper offers a brief commentary on a meta-analysis conducted by Lin, Huang and Liou (2013) in LLT, providing further statistical…

  17. Fasting plasma zeaxanthin response to Fructus barbarum L. (wolfberry; Kei Tze) in a food-based human supplementation trial.

    PubMed

    Cheng, Chung Yuen; Chung, Wai Yuen; Szeto, Yim Tong; Benzie, Iris F F

    2005-01-01

    Age-related macular degeneration (AMD) is a common disorder that causes irreversible loss of central vision. Increased intake of foods containing zeaxanthin may be effective in preventing AMD because the macula accumulates zeaxanthin and lutein, oxygenated carotenoids with antioxidant and blue light-absorbing properties. Lycium barbarum L. is a small red berry known as Fructus lycii and wolfberry in the West, and Kei Tze and Gou Qi Zi in Asia. Wolfberry is rich in zeaxanthin dipalmitate, and is valued in Chinese culture for being good for vision. The aim of this study, which was a single-blinded, placebo-controlled, human intervention trial of parallel design, was to provide data on how fasting plasma zeaxanthin concentration changes as a result of dietary supplementation with whole wolfberries. Fasting blood was collected from healthy, consenting subjects; fourteen subjects took 15 g/d wolfberry (estimated to contain almost 3 mg zeaxanthin) for 28 d. Repeat fasting blood was collected on day 29. Age- and sex-matched controls (n 13) took no wolfberry. Responses in the two groups were compared using the Mann-Whitney test. After supplementation, plasma zeaxanthin increased 2.5-fold: mean values on day 1 and 29 were 0.038 (sem 0.003) and 0.096 (sem 0.009) micromol/l (P<0.01), respectively, for the supplementation group; and 0.038 (sem 0.003) and 0.043 (sem 0.003) micromol/l (P>0.05), respectively, for the control group. This human supplementation trial shows that zeaxanthin in whole wolfberries is bioavailable and that intake of a modest daily amount markedly increases fasting plasma zeaxanthin levels. These new data will support further study of dietary strategies to maintain macular pigment density. PMID:15705234

  18. Corni fructus as the major herb of Die-Huang-Wan for lowering plasma glucose in Wistar rats.

    PubMed

    Liou, Shorong-Shii; Liu, I-Min; Hsu, Sheng-Fa; Cheng, Juei-Tang

    2004-11-01

    Die-Huang-Wan is a mixture of six herbs used to lower plasma glucose by increasing insulin secretion in normal rats. Die-Huang-Wan contains the herbs dioscorea (Dioscoreae rhizoma), cornus (Corni fructus), alisma (Rhizoma alismatis), holelen (Poria), rehmannia (Rehmanniae radix) and tree peony bark (Moutan radicis cortex). The present study was designed to clarify the major herb contributing to the plasma glucose-lowering action of Die-Huang-Wan in rats. A decrease in plasma glucose was not observed in Wistar rats treated with the cornus-deleted formula of Die-Huang-Wan; however, the action was retained in the other herb-deleted formulas containing cornus. In normal rats, the decrease in plasma glucose and increase in plasma insulin concentrations were dependent on the dose of cornus and were similar to those produced by Die-Huang-Wan. Treatment of Wistar rats with each of the other five herbs separately did not result in a decrease in plasma glucose. Moreover, the increase in plasma insulin or reduction in plasma glucose resulting from cornus treatment was blocked by atropine or 4-diphenylacetoxy-N-methylpiperidine methiodide mustard, indicating mediation of muscarinic M(3) receptors similar to that caused by Die-Huang-Wan. These results suggest that cornus is the major contributor to the plasma glucose-lowering action in Die-Huang-Wan in normal rats. PMID:15525452

  19. [Chengjiang school descendant Mr. Huang Zong-Xu's academic characteristics of acupuncture and moxibustion].

    PubMed

    Zhu, An-Ning; Meng, Xian-Jun; Qian, Lin-Chao; Sun, Xiao-Zhong

    2013-04-01

    HUANG Zong-xu, who studied from Mr. Cheng Dan-an, the founder of Chengjiang acupuncture school, is a famous acupuncturist of Fujian Province. Through collecting and sorting of Mr. Huang's theses and medical records, his academic characteristics of acupuncture and moxibustion were summarized as follows. Paying attention to meridians and collaterals and treatment based on syndrome differentiation; valuing the needling sensation as well as being good at reinforcing and reducing methods; thinking highly of taking care of spleen and stomach, ombination of needles and herbal medicine to treat difficult miscellaneous diseases; being adept in externd therapy and penetration needling and diet prescriptions, as well as attaching importance on health preserving. PMID:23819254

  20. Ephedrine pharmacokinetics after the ingestion of nutritional supplements containing Ephedra sinica (ma huang).

    PubMed

    Gurley, B J; Gardner, S F; White, L M; Wang, P L

    1998-08-01

    Nutritional supplements containing Ephedra sinica (ma huang), a botanical source of ephedrine alkaloids, have been linked to several episodes of ephedrine toxicity and at least 17 deaths, yet these products remain unregulated. Ten subjects were enrolled in a randomized, crossover study aimed at characterizing the pharmacokinetics of ephedrine after the ingestion of three commercially available ma huang products compared with a 25-mg ephedrine capsule. Pharmacokinetic parameters for botanical ephedrine were similar to those for synthetic ephedrine hydrochloride. Gender-based comparisons of Vss/F and CL/F revealed higher values for women than for men (Vss/F, 3.49 +/- 1.04 vs 2.98 +/- 0.73 l/kg; CL/F, 0.48 +/- 0.11 vs 0.37 +/- 0.11 l/hour x kg). The current study suggests that the increased incidence of ma huang toxicity does not stem from differences in the absorption of botanical ephedrine compared with synthetic ephedrine; rather, it results from accidental overdose often prompted by exaggerated off-label claims and a belief that "natural" medicinal agents are inherently safe. PMID:9712471

  1. Pharmacokinetics and cardiovascular effects of ma-huang (Ephedra sinica) in normotensive adults.

    PubMed

    White, L M; Gardner, S F; Gurley, B J; Marx, M A; Wang, P L; Estes, M

    1997-02-01

    The purpose of this study was to evaluate heart rate and blood pressure responses to a commercially available source of ma-haung, a natural source of the sympathomimetic substance, ephedrine, and to evaluate the pharmacokinetic properties of the product in normotensive, healthy adults. On day 1, twelve study participants were monitored with an ambulatory blood pressure device between hours 7 and 20. On day 2, they ingested four capsules of powdered ma-huang at hours 8 and 17 while again wearing the monitor between hours 7 and 20. Serial plasma samples were obtained and concentrations of ephedrine were analyzed by high-performance liquid chromatography. Pharmacokinetic parameters of ephedrine were determined from plasma concentration-time profiles. The ephedrine alkaloid content of each capsule was also determined by high-performance liquid chromatography. Six participants experienced a statistically significant increase in heart rate, but the effects on blood pressure were variable. The half-life, volume of distribution, clearance, and maximum concentration in plasma of ephedrine in the ma-huang product were similar to values previously reported for a 20 mg, immediate-release ephedrine tablet. Values for the absorption rate were considerably lower and time to reach maximum concentration was longer for the capsules, compared with the standard tablet. Variability in alkaloid content of ephedrine was low and yielded a mean dose of ephedrine at 19.4 mg; pseudoephedrine at 4.9 mg; and methylephedrine at 1.2 mg for a four-capsule dose. In summary, ma-haung had variable effects on blood pressure and increased heart rate in healthy, normotensive adults. Pharmacokinetic parameters for ephedrine were in agreement with those previously reported; however, the absorption rate was much slower after ingestion of ma-huang. PMID:9055137

  2. Application of the Hilbert-Huang Transform to the Search for Gravitational Waves

    NASA Technical Reports Server (NTRS)

    Camp, Jordan B.; Cannizzo, John K.; Numata, Kenji

    2007-01-01

    We present the application of a novel method of time-series analysis, the Hilbert-Huang Transform, to the search for gravitational waves. This algorithm is adaptive and does not impose a basis set on the data, and thus the time-frequency decomposition it provides is not limited by time-frequency uncertainty spreading. Because of its high time-frequency resolution it has important applications to both signal detection and instrumental characterization. Applications to the data analysis of the ground and space based gravitational wave detectors, LIGO and LISA, are described.

  3. [Characteristics of precipitation pH and conductivity at Mt. Huang].

    PubMed

    Shi, Chun-e; Deng, Xue-liang; Wu, Bi-wen; Hong, Jie; Zhang, Su; Yang, Yuan-jian

    2013-05-01

    To understand the general characteristics of pH distribution and pollution in precipitation at Mt. Huang, statistical analyses were conducted for the routine measurements of pH and conductivity (K) at Mt. Huang during 2006-2011. The results showed that: (1) Over the period of study, the annual volume weighted mean (VWM) precipitation pH varied from 4.81 to 5.57, with precipitation acidity strengthening before 2009 and weakening thereafter. The precipitation acidity showed evident seasonal variations, with the VWM pH lowest in winter (4.78), and highest in summer (5.33). The occurrence frequency of acid rain was 46% , accounting for 45% of total rainfalls and with the most frequent pH falling into weak acid to neutral rain. (2) The annual VWM K varied from 16.91 to 27.84 microS x cm(-1), with no evident trend. As for ions pollution, the precipitation was relatively clean at Mt. Huang, with the most frequent K range being below 15 microS x cm(-1), followed by 15-25 microS x cm(-1). From February 2010 to December 2011, precipitation samples were collected on daily basis for ions analysis, as well as pH and K measurement in lab. Detailed comparisons were conducted between the two sets of pH and K, one set from field measurement and the other from lab measurement. The results indicated: (1) The lab measured pH (K) was highly correlated with the field pH (K); however, the lab pH tended to move towards neutral comparing with the corresponding field pH, and the shift range was closely correlated with the field pH and rainfall. The shift range of K from field to lab was highly correlated with the total ion concentration of precipitation. The field K showed evident negative correlation with the field pH with a correlation coefficient of -0.51. (2) When sampling with nylon-polyethylene bags, the statistics showed smaller bias between two sets of pH, with higher correlation coefficient between two sets of K. Furthermore, the lab K also showed evident negative correlation with the lab pH. Comparing with the observations at other alpine sites in central to eastern China, the natural precipitation at Mt. Huang was weaker in acidity and contains lower ion concentration. PMID:23914555

  4. Simulations of IPCC SRES effect upon winter wheat growing in the Chinese Huang-Huai valley

    NASA Astrophysics Data System (ADS)

    Li, Shuyan; Cheng, Lin; Liu, Ronghua; Wang, Xinli

    2008-08-01

    Using 1994-2006 typical-station agricultural data of the Huang-Huai winter wheat zone for the adjustment and validation of the DSSAT-CERES Wheat model, which is then used with the IPCC SRES climate scenarios (A2 and B2) through a stochastic weather generator, simulation is undertaken of effects of the 2050s climate regime on winter wheat yield, growth/development and water requirement in the Huang-Huai plain. Results suggest that of the two emission schemes, A2 gives higher negative influence compared to B2; the wheat growth/development period is shortened by 18 days, on average, for the region due to global warming leading to the accelerated growth, the flowering occurring ~20 days in advance, the span from flowering to maturity shortened 1~2 days, and the regional yield reducing by ~10%, on the average. Enough irrigation will be needed to alleviate the yield decline but the wheat productivity per unit water volume is to reduce.

  5. Advantages of the Hilbert Huang transform for marine mammals signals analysis.

    PubMed

    Adam, Olivier

    2006-11-01

    While marine mammals emit variant signals (in time and frequency), the Fourier spectrogram appears to be the most widely used spectral estimator. In certain cases, this approach is suboptimal, particularly for odontocete click analysis and when the signal-to-noise ratio varies during the continuous recordings. We introduce the Hilbert Huang transform (HHT) as an efficient means for analysis of bioacoustical signals. To evaluate this method, we compare results obtained from three time-frequency representations: the Fourier spectrogram, the wavelet transform, and the Hilbert Huang transform. The results show that HHT is a viable alternative to the wavelet transform. The chosen examples illustrate certain advantages. (1) This method requires the calculation of the Hilbert transform; the time-frequency resolution is not restricted by the uncertainty principle; the frequency resolution is finer than with the Fourier spectrogram. (2) The original signal decomposition into successive modes is complete. If we were to multiply some of these modes, this would contribute to attenuate the presence of noise in the original signal and to being able to select pertinent information. (3) Frequency evolution for each mode can be analyzed as one-dimensional (1D) signal. We not need a complex 2D post-treatment as is usually required for feature extraction. PMID:17139753

  6. A Case of Ischemic Colitis Associated with the Herbal Food Supplement Ma Huang

    PubMed Central

    Song, Hyun Joo; Ryu, Kum Hei; Kim, Tae Hun; Jung, Sung-Ae; Yoo, Kwon

    2008-01-01

    Ischemic colitis is a condition that usually occurs in the elderly, as a form of vascular disease. However, ischemic colitis also occurs, though rarely, in healthy young adults. Moreover, food supplements containing Ephedra sinica or ma huang have been linked to adverse central nervous and cardiovascular events. A 40-year-old man was admitted to our emergency department after 2 episodes of abdominal pain and bloody diarrhea that lasted 24 hours. His medical history was unremarkable for risk factors of bowel ischemia, except for well-controlled hypertension. However, a weight-loss supplement, Ephedra sinica, had been prescribed for daily use during the previous month. Both abdominal/pelvic computed tomography and colonoscopy revealed findings compatible with ischemic colitis. His conditions spontaneously improved without any serious complications, and he was advised to discontinue the use of herbal medications containing ephedrine. In this paper, we describe a case of ischemic colitis that was potentially linked to the use of ma huang with a review of the relevant literature. PMID:18581601

  7. A case of ischemic colitis associated with the herbal food supplement ma huang.

    PubMed

    Song, Hyun Joo; Shim, Ki-Nam; Ryu, Kum Hei; Kim, Tae Hun; Jung, Sung-Ae; Yoo, Kwon

    2008-06-30

    Ischemic colitis is a condition that usually occurs in the elderly, as a form of vascular disease. However, ischemic colitis also occurs, though rarely, in healthy young adults. Moreover, food supplements containing Ephedra sinica or ma huang have been linked to adverse central nervous and cardiovascular events. A 40-year-old man was admitted to our emergency department after 2 episodes of abdominal pain and bloody diarrhea that lasted 24 hours. His medical history was unremarkable for risk factors of bowel ischemia, except for well-controlled hypertension. However, a weight-loss supplement, Ephedra sinica, had been prescribed for daily use during the previous month. Both abdominal/pelvic computed tomography and colonoscopy revealed findings compatible with ischemic colitis. His conditions spontaneously improved without any serious complications, and he was advised to discontinue the use of herbal medications containing ephedrine. In this paper, we describe a case of ischemic colitis that was potentially linked to the use of ma huang with a review of the relevant literature. PMID:18581601

  8. [Herbological studies on the Chinese crude drug ma-huang--part 2--on the confusion between ma-huang, Ephedrae Herba, and Equisetum plants in Medieval China and Japan].

    PubMed

    Yoshizawa, Chieko; Kitade, Makiko; Mikage, Masayuki

    2006-01-01

    As we previously reported, ma-huang ([Chinese characters: see text], Ephedrae Herba) has been sometimes used together with mu-zei ([Chinese characters: see text], Equiseti Herba) in medieval China and Japan. We herbologically studied this confusion and found that, in China, the confusion was found in literature in the Song dynasty, and Li Shi-Zhen recorded in Ben-cao-gang-mu that both drugs were morphologically and medicinally the same in the Ming dynasty. Though the main reason why the plant of the genus Equisetum, especially E. ramosissimum Desf., had been substituted for Ephedra plants is thought to be their morphological similarity, the doctors who lived in the area where no Ephedra plants grew might have used Equisetum plants as ma-huang based on Li's description. Owing to this confusion in China, the plants of E. ramosissimum were sometimes imported to Japan as ma-huang, and it caused the tentative use of E. ramosissimum as ma-huang in the middle of the Edo era in Japan. PMID:17153110

  9. A framework for the damage evaluation of acoustic emission signals through Hilbert-Huang transform

    NASA Astrophysics Data System (ADS)

    Siracusano, Giulio; Lamonaca, Francesco; Tomasello, Riccardo; Garescì, Francesca; Corte, Aurelio La; Carnì, Domenico Luca; Carpentieri, Mario; Grimaldi, Domenico; Finocchio, Giovanni

    2016-06-01

    The acoustic emission (AE) is a powerful and potential nondestructive testing method for structural monitoring in civil engineering. Here, we show how systematic investigation of crack phenomena based on AE data can be significantly improved by the use of advanced signal processing techniques. Such data are a fundamental source of information that can be used as the basis for evaluating the status of the material, thereby paving the way for a new frontier of innovation made by data-enabled analytics. In this article, we propose a framework based on the Hilbert-Huang Transform for the evaluation of material damages that (i) facilitates the systematic employment of both established and promising analysis criteria, and (ii) provides unsupervised tools to achieve an accurate classification of the fracture type, the discrimination between longitudinal (P-) and traversal (S-) waves related to an AE event. The experimental validation shows promising results for a reliable assessment of the health status through the monitoring of civil infrastructures.

  10. [Analysis on academic frame of A-B classic of acupuncture and moxibustion by Huang Fumi].

    PubMed

    Zhang, Jianbin

    2015-01-01

    The acupuncture-moxibustion academic frame system was firstly and systematically established in A-B Classic of Acupuncture and Moxibustion authored by HUANG Fu-mi, which explained the knowledge and logical relationship among different parts of acupuncture-moxibustion. The academic frame consisted of acupuncture-moxibustion basis and clinical application. In the basic theory, zang-fu, qi-blood, meridians, acupoint, pulse diagnosis, acupuncture manipulation, etiology and pathogenesis, etc. were included; in the clinical application, various kinds of clinical diseases and their acupuncture treatment were included. The academic frame established by A-B Classic of Acupuncture and Moxibustion is broader than the modern academic frame of acupuncture-moxibustion, in which the attribution and location of four-seas theory has certain differences from modern acupuncture-moxibustion theory. PMID:25906580

  11. Laser tissue welding analyzed using fluorescence, Stokes shift spectroscopy, and Huang-Rhys parameter.

    PubMed

    Sriramoju, Vidyasagar; Alfano, Robert R

    2012-02-01

    Near infrared (NIR) continuous wave laser radiation at the 1,450 nm wavelength was used to weld porcine aorta and skin samples via the absorption of combitional vibrational modes of native water in the tissues. The fluorescence spectra were measured from the key native molecules of welded and non-welded tissues at specific excitation and emission wavelengths from collagen, elastin, and tryptophan. The changes in the fluorescence intensities and differences in Stokes shift (Δν(ss) ) of key native fluorophores were measured to differentiate the Huang-Rhys parameter values (S) of the chromophores. The strength of coupling depends on the local electron-vibration intra-tissue molecular environment and the amount of polar solvent water surrounding the net charges on collagen, elastin, and tryptophan. The S values for both non-welded and welded tissues were almost the same and less than 3, suggesting minimal changes in the local molecular environment as a result of welding. PMID:22076914

  12. Hilbert-Huang processing for single-exposure two-dimensional grating interferometry.

    PubMed

    Trusiak, Maciej; Patorski, Krzysztof; Pokorski, Krzysztof

    2013-11-18

    Single-shot crossed-type fringe pattern processing and analysis method called Hilbert-Huang grating interferometry (HHGI) is proposed. It consist of three main procedures: (1) crossed pattern is resolved into two fringe families using novel orthogonal empirical mode decomposition approach, (2) separated fringe sets are filtered using modified automatic selective reconstruction aided by enhanced fast empirical mode decomposition and mutual information detrending, and (3) Hilbert spiral transform is employed for fringe phase demodulation. Numerical and experimental studies corroborate the validity, versatility and robustness of the proposed HHGI technique. It can be successfully applied to multiplicative and additive type crossed patterns with sinusoidal and binary orthogonal component structures. Efficient adaptive filtering enables successful fast processing and analysis of complex and defected patterns. PMID:24514346

  13. Event Trigger Generator for Gravitational-Wave Data based on Hilbert-Huang Transform

    NASA Astrophysics Data System (ADS)

    Son, Edwin J.; Chu, Hyoungseok; Kim, Young-Min; Blackburn, Lindy; Hayama, Kazuhiro; Kim, Hwansun; Oh, John J.; Oh, Sang Hoon; Robinet, Florent

    2015-08-01

    The Hilbert-Huang Transform (HHT) is composed of the Empirical Mode Decomposition (EMD) and the Hilbert Spectral Analysis (HSA). The EMD decomposes any time series data into a small number of components called the Intrinsic Mode Functions (IMFs), compared to the Discrete Fourier Transform which decomposes a data into a large number of harmonic functions. Each IMF has varying amplitude and frequency with respect to time, which can be obtained by HSA. The time resolution of the modes in HHT is the same as that of the given time series, while in the Wavelet Transform, Constant Q Transform and Short-Time Fourier Transform, there is a tradeoff between the resolutions in frequency and time. Based on the time-dependent amplitudes of IMFs, we develop an Event Trigger Generator and demonstrate its efficiency by applying it to gravitational-wave mock data.

  14. A new method for investigating heterogeneities from well logs using the Hilbert-Huang transform

    NASA Astrophysics Data System (ADS)

    Gaci, Said; Zaourar, Naima; Hachay, Olga

    2015-04-01

    Borehole logs exhibit multi-scale properties that cannot be analyzed using the conventional tools. Here, we propose a new method based on Hilbert-Huang transform (HHT), a combination of the empirical mode decomposition (EMD) and Hilbert transform (HT), for estimating a local scaling coefficient from well logs. This parameter measures heterogeneities degree of the layers crossed by the borehole. The proposed technique has been applied on P- and S-wave seismic velocity logs recorded at the KTB main borehole drilled for the German Continental Deep Drilling program. The calculated depth-dependent scaling parameter highlighted the lithological discontinuities occurred within the logged depth interval, and allowed to measure the complexity of underground heterogeneities. To conclude, the suggested method presents a new way to explore multi-scale features of the logs data, and may bring additional information to the conventional analysis tools. More datasets are needed to establish a possible relationship between the local scaling parameter and lithology.

  15. A Meta-Discursive Analysis of Online Comments of Chinese Netizens on Huang Xiaoming's Appropriation of English

    ERIC Educational Resources Information Center

    Yan, Xi

    2014-01-01

    This paper explores the ideologies of English in China through a meta-discursive analysis of Chinese netizens' comments on the performance of English by Huang Xiaoming, a famous Chinese actor. By applying Park and Wee's framework for analysing ideological evaluations of appropriation (i.e. ideologies of allegiance, competence, and

  16. A Meta-Discursive Analysis of Online Comments of Chinese Netizens on Huang Xiaoming's Appropriation of English

    ERIC Educational Resources Information Center

    Yan, Xi

    2014-01-01

    This paper explores the ideologies of English in China through a meta-discursive analysis of Chinese netizens' comments on the performance of English by Huang Xiaoming, a famous Chinese actor. By applying Park and Wee's framework for analysing ideological evaluations of appropriation (i.e. ideologies of allegiance, competence, and…

  17. The Early ULF Signal of the Gigantic Jets Revealed By Hilbert-Huang Transform

    NASA Astrophysics Data System (ADS)

    Huang, Po-Hsun; Bing-Chih Chen, Alfred

    2015-04-01

    The conventional Fourier analysis on the sferics in ULF and VLF bandpasses has been done for years. Several phenomena e.g. whistler and Schumann resonance have been well studied by the Fourier spectrum comprehensively. But the Fourier analysis is computed by an integration over time, therefore, the temporal resolution is smoothed, and limited not only by the sampling rate but also the size of the integration window. The instantaneous frequency can't be obtained through this conventional approach. We introduce the Hilbert-Huang transform (HHT) instead of Fourier transform to analyze the sferics of TLEs recorded at Lulin observatory. The Hilbert-Huang transform decomposes a signal into so-called intrinsic mode functions (IMF), and derive instantaneous frequency data by differentiating the phase angle yielded by Hilbert transform. Our analysis of HHT on several gigantic jets recorded by ground observation surprisingly revealed an early signal of frequency-change during the phase of the leading jet, and this early signal can not be identified by Fourier analysis. In the phase of leading jet, the amplitude of the sferics remains a constant and no significant features are recognized in the recorded waveform, but an obvious frequency change about 100-200 millisecond prior to the main discharge of the full development jets (FDJs), which can be clearly recognized in the HHT spectra of all observed gigantic jets. From a further simulation, this frequency change is confirmed to come from the nature of the discharge, not an alias or a false signal generated by the analysis method. This early signal may implies an in-cloud discharge process which is suggested by Krehbiel et al. [2008

  18. Time-frequency analysis of non-stationary fusion plasma signals using an improved Hilbert-Huang transform

    SciTech Connect

    Liu, Yangqing Tan, Yi; Xie, Huiqiao; Wang, Wenhao; Gao, Zhe

    2014-07-15

    An improved Hilbert-Huang transform method is developed to the time-frequency analysis of non-stationary signals in tokamak plasmas. Maximal overlap discrete wavelet packet transform rather than wavelet packet transform is proposed as a preprocessor to decompose a signal into various narrow-band components. Then, a correlation coefficient based selection method is utilized to eliminate the irrelevant intrinsic mode functions obtained from empirical mode decomposition of those narrow-band components. Subsequently, a time varying vector autoregressive moving average model instead of Hilbert spectral analysis is performed to compute the Hilbert spectrum, i.e., a three-dimensional time-frequency distribution of the signal. The feasibility and effectiveness of the improved Hilbert-Huang transform method is demonstrated by analyzing a non-stationary simulated signal and actual experimental signals in fusion plasmas.

  19. Damage Modes Recognition and Hilbert-Huang Transform Analyses of CFRP Laminates Utilizing Acoustic Emission Technique

    NASA Astrophysics Data System (ADS)

    WenQin, Han; Ying, Luo; AiJun, Gu; Yuan, Fuh-Gwo

    2015-08-01

    Discrimination of acoustic emission (AE) signals related to different damage modes is of great importance in carbon fiber-reinforced plastic (CFRP) composite materials. To gain a deeper understanding of the initiation, growth and evolution of the different types of damage, four types of specimens for different lay-ups and orientations and three types of specimens for interlaminar toughness tests are subjected to tensile test along with acoustic emission monitoring. AE signals have been collected and post-processed, the statistical results show that the peak frequency of AE signal can distinguish various damage modes effectively. After a AE signal were decomposed by Empirical Mode Decomposition (EMD) method, it may separate and extract all damage modes included in this AE signal apart from damage mode corresponding to the peak frequency. Hilbert-Huang Transform (HHT) of AE signals can clearly illustrate the frequency distribution of Intrinsic Mode Functions (IMF) components in time-scale in different damage stages, and can calculate accurate instantaneous frequency for damage modes recognition to help understanding the damage process.

  20. A combinatorial filtering method for magnetotelluric time-series based on Hilbert-Huang transform

    NASA Astrophysics Data System (ADS)

    Cai, Jianhua

    2014-11-01

    Magnetotelluric (MT) time-series are often contaminated with noise from natural or man-made processes. A substantial improvement is possible when the time-series are presented as clean as possible for further processing. A combinatorial method is described for filtering of MT time-series based on the Hilbert-Huang transform that requires a minimum of human intervention and leaves good data sections unchanged. Good data sections are preserved because after empirical mode decomposition the data are analysed through hierarchies, morphological filtering, adaptive threshold and multi-point smoothing, allowing separation of noise from signals. The combinatorial method can be carried out without any assumption about the data distribution. Simulated data and the real measured MT time-series from three different regions, with noise caused by baseline drift, high frequency noise and power-line contribution, are processed to demonstrate the application of the proposed method. Results highlight the ability of the combinatorial method to pick out useful signals, and the noise is suppressed greatly so that their deleterious influence is eliminated for the MT transfer function estimation.

  1. Damage Modes Recognition and Hilbert-Huang Transform Analyses of CFRP Laminates Utilizing Acoustic Emission Technique

    NASA Astrophysics Data System (ADS)

    WenQin, Han; Ying, Luo; AiJun, Gu; Yuan, Fuh-Gwo

    2016-04-01

    Discrimination of acoustic emission (AE) signals related to different damage modes is of great importance in carbon fiber-reinforced plastic (CFRP) composite materials. To gain a deeper understanding of the initiation, growth and evolution of the different types of damage, four types of specimens for different lay-ups and orientations and three types of specimens for interlaminar toughness tests are subjected to tensile test along with acoustic emission monitoring. AE signals have been collected and post-processed, the statistical results show that the peak frequency of AE signal can distinguish various damage modes effectively. After a AE signal were decomposed by Empirical Mode Decomposition (EMD) method, it may separate and extract all damage modes included in this AE signal apart from damage mode corresponding to the peak frequency. Hilbert-Huang Transform (HHT) of AE signals can clearly illustrate the frequency distribution of Intrinsic Mode Functions (IMF) components in time-scale in different damage stages, and can calculate accurate instantaneous frequency for damage modes recognition to help understanding the damage process.

  2. Combined therapy of Di-Huang-Yi-Zhi with Donepezil in patients with Parkinson's disease dementia.

    PubMed

    Gu, Chao; Shen, Ting; An, Hongmei; Yuan, Canxing; Zhou, Jie; Ye, Qing; Liu, Tao; Wang, Xiuwei; Zhang, Tianli

    2015-10-01

    Here we conducted a randomized and double-blind study attempting to explore the safety and efficacy of combined therapy of Di-Huang-Yi-Zhi (DHYZ) with donepezil in treating Parkinson's disease dementia (PDD). Sixty PDD patients were included and randomly divided into control group and DHYZ group. All patients were given donepezil (5 mg last for a month, then 10 mg for the rest months, once daily), while patients in DHYZ group were additionally administrated with DHYZ (150 ml, twice daily). The measurement subjects included mini-mental state examination (MMSE), Montreal cognitive assessment (MoCA), Alzheimer's Disease Assessment Scale-Cognitive Subscale (ADAS-Cog), the Barthel Index for activities of daily living (ADL) and Traditional Chinese medical (TCM) symptoms before and after treatment in this study. The whole study lasted for six months. Significant differences were observed on MMSE, MoCA, ADAS-Cog, ADL and TCM in both control and DHYZ group (P<0.05 or P<0.01) before and after drug treatment. Furthermore, there were more obvious changes of MMSE, MoCA, ADAS-Cog, ADL and TCM scores compared the DHYZ group with the control group (P<0.01) which suggested the DHYZ group showed a more effective improvement on cognition, behavior as well global function. In conclusion, the combined therapy of DHYZ with donepezil showed a more effective improvement in PDD and the underlying mechanism may be related to the synergic amelioration of cholinergic system between them. PMID:26297124

  3. Application of Hilbert-Huang Transform for Improved Defect Detection in Terahertz NDE of Shuttle Tiles

    NASA Technical Reports Server (NTRS)

    Anastasi, Robert F.; Madaras, Eric I.

    2005-01-01

    Terahertz NDE is being examined as a method to inspect the adhesive bond-line of Space Shuttle tiles for defects. Terahertz signals are generated and detected, using optical excitation of biased semiconductors with femtosecond laser pulses. Shuttle tile samples were manufactured with defects that included repair regions unbond regions, and other conditions that occur in Shuttle structures. These samples were inspected with a commercial terahertz NDE system that scanned a tile and generated a data set of RF signals. The signals were post processed to generate C-scan type images that are typically seen in ultrasonic NDE. To improve defect visualization the Hilbert-Huang Transform, a transform that decomposes a signal into oscillating components called intrinsic mode functions, was applied to test signals identified as being in and out of the defect regions and then on a complete data set. As expected with this transform, the results showed that the decomposed low-order modes correspond to signal noise while the high-order modes correspond to low frequency oscillations in the signal and mid-order modes correspond to local signal oscillations. The local oscillations compare well with various reflection interfaces and the defect locations in the original signal.

  4. An analysis method for magnetotelluric data based on the Hilbert-Huang Transform

    NASA Astrophysics Data System (ADS)

    Cai, Jian-Hua; Tang, Jing-Tian; Hua, Xi-Rui; Gong, Yu-Rong

    2009-06-01

    Prevailing methods of magnetotelluric (MT) data analysis determine the spectra using variations of the Fourier Transform (FT), which is based on the principle of signal stationarity. However, MT data series are non-stationary random signals that do not meet the basic requirements of conventional methods based on the FT. In recent years, the Hilbert-Huang Transform (HHT) has been regarded as a powerful tool for adaptive analysis of non-linear and non-stationary signals. This paper proposes for the first time the adoption of a new method of analysis for MT data, and focuses on two aspects that are facilitated by applying the HHT. The first aspect is the pretreatment of the MT time series data through selecting MT data subsets, and noise suppression; the other concerns the determination of the impedance and apparent resistivity using the HHT instantaneous spectrum. The conclusion reached through discussion of the first aspect is that the proposed methods can greatly improve the quality of MT data. The conclusion drawn from the second aspect is that the HHT instantaneous spectrum method can overcome the problems described above, and obtain stable and reliable estimation of the impedance tensor, and thus naturally minimise the estimation bias brought about by the non-stationary characteristics of MT data. Therefore, the HHT method is effective in analysing MT data and is able to generate meaningful geological information.

  5. Bioaccessibility and excretion of arsenic in Niu Huang Jie Du Pian pills

    SciTech Connect

    Koch, Iris; Sylvester, Steven; Lai, Vivian W.-M.; Owen, Andrew; Reimer, Kenneth J. Cullen, William R.

    2007-08-01

    Traditional Chinese medicines (TCMs) often contain significant levels of potentially toxic elements, including arsenic. Niu Huang Jie Du Pian pills were analyzed to determine the concentration, bioaccessibility (arsenic fraction soluble in the human gastrointestinal system) and chemical form (speciation) of arsenic. Arsenic excretion in urine (including speciation) and facial hair were studied after a one-time ingestion. The pills contained arsenic in the form of realgar, and although the total arsenic that was present in a single pill was high (28 mg), the low bioaccessibility of this form of arsenic predicted that only 4% of it was available for absorption into the bloodstream (1 mg of arsenic per pill). The species of arsenic that were solubilized were inorganic arsenate (As(V)) and arsenite (As(III)) but DMAA and MMAA were detected in urine. Two urinary arsenic excretion peaks were observed: an initial peak several (4-8) hours after ingestion corresponding to the excretion of predominantly As(III), and a larger peak at 14 h corresponding predominantly to DMAA and MMAA. No methylated As(III) species were observed. Facial hair analysis revealed that arsenic concentrations did not increase significantly as a result of the ingestion. Arsenic is incompletely soluble under human gastrointestinal conditions, and is metabolized from the inorganic to organic forms found in urine. Bioaccessible arsenic is comparable to the quantity excreted. Facial hair as a bio-indicator should be further tested.

  6. Segmentation of Killer Whale Vocalizations Using the Hilbert-Huang Transform

    NASA Astrophysics Data System (ADS)

    Adam, Olivier

    2008-12-01

    The study of cetacean vocalizations is usually based on spectrogram analysis. The feature extraction is obtained from 2D methods like the edge detection algorithm. Difficulties appear when signal-to-noise ratios are weak or when more than one vocalization is simultaneously emitted. This is the case for acoustic observations in a natural environment and especially for the killer whales which swim in groups. To resolve this problem, we propose the use of the Hilbert-Huang transform. First, we illustrate how few modes (5) are satisfactory for the analysis of these calls. Then, we detail our approach which consists of combining the modes for extracting the time-varying frequencies of the vocalizations. This combination takes advantage of one of the empirical mode decomposition properties which is that the successive IMFs represent the original data broken down into frequency components from highest to lowest frequency. To evaluate the performance, our method is first applied on the simulated chirp signals. This approach allows us to link one chirp to one mode. Then we apply it on real signals emitted by killer whales. The results confirm that this method is a favorable alternative for the automatic extraction of killer whale vocalizations.

  7. Structural modal parameter identification and damage diagnosis based on Hilbert-Huang transform

    NASA Astrophysics Data System (ADS)

    Han, Jianping; Zheng, Peijuan; Wang, Hongtao

    2014-03-01

    Traditional modal parameter identification methods have many disadvantages, especially when used for processing nonlinear and non-stationary signals. In addition, they are usually not able to accurately identify the damping ratio and damage. In this study, methods based on the Hilbert-Huang transform (HHT) are investigated for structural modal parameter identification and damage diagnosis. First, mirror extension and prediction via a radial basis function (RBF) neural network are used to restrain the troublesome end-effect issue in empirical mode decomposition (EMD), which is a crucial part of HHT. Then, the approaches based on HHT combined with other techniques, such as the random decrement technique (RDT), natural excitation technique (NExT) and stochastic subspace identification (SSI), are proposed to identify modal parameters of structures. Furthermore, a damage diagnosis method based on the HHT is also proposed. Time-varying instantaneous frequency and instantaneous energy are used to identify the damage evolution of the structure. The relative amplitude of the Hilbert marginal spectrum is used to identify the damage location of the structure. Finally, acceleration records at gauge points from shaking table testing of a 12-story reinforced concrete frame model are taken to validate the proposed approaches. The results show that the proposed approaches based on HHT for modal parameter identification and damage diagnosis are reliable and practical.

  8. Hilbert-Huang transform analysis of dynamic and earthquake motion recordings

    USGS Publications Warehouse

    Zhang, R.R.; Ma, S.; Safak, E.; Hartzell, S.

    2003-01-01

    This study examines the rationale of Hilbert-Huang transform (HHT) for analyzing dynamic and earthquake motion recordings in studies of seismology and engineering. In particular, this paper first provides the fundamentals of the HHT method, which consist of the empirical mode decomposition (EMD) and the Hilbert spectral analysis. It then uses the HHT to analyze recordings of hypothetical and real wave motion, the results of which are compared with the results obtained by the Fourier data processing technique. The analysis of the two recordings indicates that the HHT method is able to extract some motion characteristics useful in studies of seismology and engineering, which might not be exposed effectively and efficiently by Fourier data processing technique. Specifically, the study indicates that the decomposed components in EMD of HHT, namely, the intrinsic mode function (IMF) components, contain observable, physical information inherent to the original data. It also shows that the grouped IMF components, namely, the EMD-based low- and high-frequency components, can faithfully capture low-frequency pulse-like as well as high-frequency wave signals. Finally, the study illustrates that the HHT-based Hilbert spectra are able to reveal the temporal-frequency energy distribution for motion recordings precisely and clearly.

  9. Diurnal variation of surface ozone in mountainous areas: Case study of Mt. Huang, East China.

    PubMed

    Zhang, Lei; Jin, Lianji; Zhao, Tianliang; Yin, Yan; Zhu, Bin; Shan, Yunpeng; Guo, Xiaomei; Tan, Chenghao; Gao, Jinhui; Wang, Haoliang

    2015-12-15

    To explore the variations in atmospheric environment over mountainous areas, measurements were made from an intensive field observation at the summit of Mt. Huang (30.13°N, 118.15°E, 1841m above sea level), a rural site located in East China, from June to August 2011. The measurements revealed a diurnal change of surface O3 with low concentrations during the daytime and high concentrations during the nighttime. The causes of diurnal O3 variations over the mountain peak in East China were investigated by using a fairly comprehensive WRF-Chem and HYSPLIT4 modeling approach with observational analysis. By varying model inputs and comparing the results to a baseline modeling and actual air quality observations, it is found that nearby ozone urban/anthropogenic emission sources were contributing to a nighttime increase in mountaintop ozone levels due to a regional transport lag and residual layer effects. Positive correlation of measured O3 and CO concentrations suggested that O3 was associated with anthropogenic emissions. Sensitivity modeling experiments indicated that local anthropogenic emissions had little impact on the diurnal pattern of O3. The diurnal pattern of O3 was mainly influenced by regional O3 transport from the surrounding urban areas located 100-150km away from the summit, with a lag time of 10h for transport. PMID:26318811

  10. Using Bioinformatics Approach to Explore the Pharmacological Mechanisms of Multiple Ingredients in Shuang-Huang-Lian

    PubMed Central

    Zhang, Bai-xia; Li, Jian; Gu, Hao; Li, Qiang; Zhang, Qi; Zhang, Tian-jiao; Wang, Yun; Cai, Cheng-ke

    2015-01-01

    Due to the proved clinical efficacy, Shuang-Huang-Lian (SHL) has developed a variety of dosage forms. However, the in-depth research on targets and pharmacological mechanisms of SHL preparations was scarce. In the presented study, the bioinformatics approaches were adopted to integrate relevant data and biological information. As a result, a PPI network was built and the common topological parameters were characterized. The results suggested that the PPI network of SHL exhibited a scale-free property and modular architecture. The drug target network of SHL was structured with 21 functional modules. According to certain modules and pharmacological effects distribution, an antitumor effect and potential drug targets were predicted. A biological network which contained 26 subnetworks was constructed to elucidate the antipneumonia mechanism of SHL. We also extracted the subnetwork to explicitly display the pathway where one effective component acts on the pneumonia related targets. In conclusions, a bioinformatics approach was established for exploring the drug targets, pharmacological activity distribution, effective components of SHL, and its mechanism of antipneumonia. Above all, we identified the effective components and disclosed the mechanism of SHL from the view of system. PMID:26495421

  11. Microbial Diversity Analysis of Fermented Mung Beans (Lu-Doh-Huang) by Using Pyrosequencing and Culture Methods

    PubMed Central

    Chao, Shiou-Huei; Huang, Hui-Yu; Chang, Chuan-Hsiung; Yang, Chih-Hsien; Cheng, Wei-Shen; Kang, Ya-Huei; Watanabe, Koichi; Tsai, Ying-Chieh

    2013-01-01

    In Taiwanese alternative medicine Lu-doh-huang (also called Pracparatum mungo), mung beans are mixed with various herbal medicines and undergo a 4-stage process of anaerobic fermentation. Here we used high-throughput sequencing of the 16S rRNA gene to profile the bacterial community structure of Lu-doh-huang samples. Pyrosequencing of samples obtained at 7 points during fermentation revealed 9 phyla, 264 genera, and 586 species of bacteria. While mung beans were inside bamboo sections (stages 1 and 2 of the fermentation process), family Lactobacillaceae and genus Lactobacillus emerged in highest abundance; Lactobacillus plantarum was broadly distributed among these samples. During stage 3, the bacterial distribution shifted to family Porphyromonadaceae, and Butyricimonas virosa became the predominant microbial component. Thereafter, bacterial counts decreased dramatically, and organisms were too few to be detected during stage 4. In addition, the microbial compositions of the liquids used for soaking bamboo sections were dramatically different: Exiguobacterium mexicanum predominated in the fermented soybean solution whereas B. virosa was predominant in running spring water. Furthermore, our results from pyrosequencing paralleled those we obtained by using the traditional culture method, which targets lactic acid bacteria. In conclusion, the microbial communities during Lu-doh-huang fermentation were markedly diverse, and pyrosequencing revealed a complete picture of the microbial consortium. PMID:23700436

  12. Microbial diversity analysis of fermented mung beans (Lu-Doh-Huang) by using pyrosequencing and culture methods.

    PubMed

    Chao, Shiou-Huei; Huang, Hui-Yu; Chang, Chuan-Hsiung; Yang, Chih-Hsien; Cheng, Wei-Shen; Kang, Ya-Huei; Watanabe, Koichi; Tsai, Ying-Chieh

    2013-01-01

    In Taiwanese alternative medicine Lu-doh-huang (also called Pracparatum mungo), mung beans are mixed with various herbal medicines and undergo a 4-stage process of anaerobic fermentation. Here we used high-throughput sequencing of the 16S rRNA gene to profile the bacterial community structure of Lu-doh-huang samples. Pyrosequencing of samples obtained at 7 points during fermentation revealed 9 phyla, 264 genera, and 586 species of bacteria. While mung beans were inside bamboo sections (stages 1 and 2 of the fermentation process), family Lactobacillaceae and genus Lactobacillus emerged in highest abundance; Lactobacillus plantarum was broadly distributed among these samples. During stage 3, the bacterial distribution shifted to family Porphyromonadaceae, and Butyricimonas virosa became the predominant microbial component. Thereafter, bacterial counts decreased dramatically, and organisms were too few to be detected during stage 4. In addition, the microbial compositions of the liquids used for soaking bamboo sections were dramatically different: Exiguobacterium mexicanum predominated in the fermented soybean solution whereas B. virosa was predominant in running spring water. Furthermore, our results from pyrosequencing paralleled those we obtained by using the traditional culture method, which targets lactic acid bacteria. In conclusion, the microbial communities during Lu-doh-huang fermentation were markedly diverse, and pyrosequencing revealed a complete picture of the microbial consortium. PMID:23700436

  13. Grundsätze über die Anlagen neuer Sternwarten mit Beziehung auf die Sternwarte der Universität Göttingen. Von Georg Heinrich Borheck

    NASA Astrophysics Data System (ADS)

    Beuermann, Klaus; Borheck, Georg Heinrich

    Die Göttinger Sternwarte, Wirkungsstätte des berühmten Gelehrten Carl Friedrich Gauß, ist ein bedeutendes Baudenkmal. Im Jahre 2005 wird sie gemeinsam von der Georg-August-Universität und der Akademie der Wissenschaften zu Göttingen renoviert, um dann als repräsentatives Gebäude der Universität und Arbeitsstätte der Akademie zu dienen. Die Nutzung der historischen Räume für Ausstellungen macht diesen imposanten Bau erstmals der Öffentlichkeit zugänglich. Die Sternwarte war bei ihrer Errichtung vor 200 Jahren ein nach seinerzeit neuesten wissenschaftlichen Erkenntnissen konzipierter Bau, der die Universität Göttingen in eine der vordersten Stellen Europa rückte. Auch aufgrund ihrer Architektur ist sie ein großer Wurf des Göttinger Universitätsbaumeisters Georg Heinrich Borheck. Durch die Kriegswirren der Napoleonischen Zeit zerschlug sich Borhecks Versuch einer Publikation seiner Beschreibung des Baus der Göttinger Sternwarte 1805. Doch seine Schrift ist auch heute noch aktuell und wird mit diesem Band erstmals einer breiten Öffentlichkeit zugängig gemacht. Er zeigt die Grundsätze, nach denen damals öffentliche Bauten konzipiert wurden, erläutert die Bedeutung des Baus aus kunst- und wissenschaftshistorischer Sicht und informiert über die Pläne zur Restaurierung der Sternwarte in einem separaten Beitrag und im Geleitwort des Präsidenten der Georg-August Universität Prof. Dr. Dr. h. c. Kurt von Figura.

  14. [The false positive reaction of the Triage panel drug-of-abuse by herbal drugs ma-huang (Ephedra sinica (Ephedraceae))].

    PubMed

    Nishiguchi, M; Kinoshita, H; Higasa, K; Taniguchi, T; Ouchi, H; Minami, T; Marukawa, S; Yoshinaga, K; Yamauchi, J; Aoki, S; Hishida, S

    2001-11-01

    We investigated false-positive reactions obtained from a drug screening test using a Triage panel. We detected 2 cases giving false-positive reaction for AMP (amphetamine, methamphetamine) during the screening of 187 normal subjects. Subsequent follow up testing by high-performance liquid chromatography (HPLC), showed both to be false-positive reactions. As both cases have a history of ingesting the herbal drug, Ma-huang (Ephedra sinica (Ephedraceae)), containing ephedrine, we examined the relationship between false-positive reactions on Triage and Ma-huang. All urine samples collected from 7 healthy volunteers following administration of Ma-huang indicated AMP positive on Triage. Also a high ratio of AMP positives was observed in the patients who were administered Ma-huang-containing drugs at the hospital. However, none of them were identified as true-positives by HPLC or gas chromatography mass spectrometry (GC/MS) analysis. The extract of Ma-huang contained in herbal drugs, which otherwise contain neither amphetamine nor its derivatives, gives (AMP) positive indications on Triage. We speculate that unidentified components of Ma-huang cause the false-positive reactions. We suggest that follow-up tests by GC/MS or HPLC are needed wherever a positive result is obtained from a screening test by Triage. Furthermore, it will be established to continue collecting information on prescribed and non-prescribed drugs. PMID:11905042

  15. Monitoring Rock Failure Processes Using the Hilbert-Huang Transform of Acoustic Emission Signals

    NASA Astrophysics Data System (ADS)

    Zhang, Ji; Peng, Weihong; Liu, Fengyu; Zhang, Haixiang; Li, Zhijian

    2016-02-01

    Rock fracturing generates acoustic emission (AE) signals that have statistical parameters referred to as AE signal parameters (AESP). Identification of rock fracturing or the failure process stage using such data raises several challenges. This study proposes a Hilbert-Huang transform-based AE processing approach to capture the time-frequency characteristics of both AE signals and AESP during rock failure processes. The damage occurring in tested rock specimens can be illustrated through analysis using this method. In this study, the specimens were 25 × 60 × 150 mm3 in size and were compressed at a displacement rate of 0.05 mm/min until failure. The recorded data included force and displacement, AE signals, and AESP. The AESP in the last third of the strain range period and 14 typical moments of strong AE signals were selected for further investigation. These results show that AE signals and AESP can be jointly used for identification of deformation stages. The transition between linear and nonlinear deformation stages was found to last for a short period in this process. The instantaneous frequency of the AE effective energy rate increased linearly from 0.5 to 1.5 Hz. Attenuation of elastic waves spreading in rock samples developed with deformation, as illustrated in the Hilbert spectra of AE signals. This attenuation is frequency dependent. Furthermore, AE signals in the softening process showed a complex frequency distribution attributed to the mechanical properties of the tested specimen. The results indicate that rock failure is predictable. The novel technology applied in this study is feasible for analysis of the entire deformation process, including softening and failure processes.

  16. Hilbert-Huang transform for analysis of heart rate variability in cardiac health.

    PubMed

    Li, Helong; Kwong, Sam; Yang, Lihua; Huang, Daren; Xiao, Dongping

    2011-01-01

    This paper introduces a modified technique based on Hilbert-Huang transform (HHT) to improve the spectrum estimates of heart rate variability (HRV). In order to make the beat-to-beat (RR) interval be a function of time and produce an evenly sampled time series, we first adopt a preprocessing method to interpolate and resample the original RR interval. Then, the HHT, which is based on the empirical mode decomposition (EMD) approach to decompose the HRV signal into several monocomponent signals that become analytic signals by means of Hilbert transform, is proposed to extract the features of preprocessed time series and to characterize the dynamic behaviors of parasympathetic and sympathetic nervous system of heart. At last, the frequency behaviors of the Hilbert spectrum and Hilbert marginal spectrum (HMS) are studied to estimate the spectral traits of HRV signals. In this paper, two kinds of experiment data are used to compare our method with the conventional power spectral density (PSD) estimation. The analysis results of the simulated HRV series show that interpolation and resampling are basic requirements for HRV data processing, and HMS is superior to PSD estimation. On the other hand, in order to further prove the superiority of our approach, real HRV signals are collected from seven young health subjects under the condition that autonomic nervous system (ANS) is blocked by certain acute selective blocking drugs: atropine and metoprolol. The high-frequency power/total power ratio and low-frequency power/high-frequency power ratio indicate that compared with the Fourier spectrum based on principal dynamic mode, our method is more sensitive and effective to identify the low-frequency and high-frequency bands of HRV. PMID:21383423

  17. Hilbert-Huang decomposition of time signals for structural damage detection

    NASA Astrophysics Data System (ADS)

    Pai, P. Frank; Huang, Lu

    2006-03-01

    This paper presents methods for characterizing nonlinearities and sudden disturbances in stationary/transient responses by decomposing signals using the Hilbert-Huang transform (HHT) and a sliding-window fitting (SWF) technique. Similar to the wavelet transform SWF uses windowed regular harmonics and their orthogonality to extract local harmonic components. However, SWF decomposes a signal into less components because it allows distorted harmonics, and it provides time-varying amplitudes and frequencies of extracted components that can reveal system's nonlinearities. To extract components from a signal HHT uses the apparent time scales shown by the local maxima and minima of the signal (instead of using orthogonality of chosen fitting functions) and cubic spline fitting of extrema to sequentially sift components of different time scales, starting from highfrequency ones to low-frequency ones. Because it does not use orthogonality of functions, HHT provides more accurate time-varying amplitudes and frequencies of extracted components for accurate estimation of system characteristics and nonlinearities. Because the first extracted component contains all original discontinuities, its time-varying amplitude and frequency are excellent indicators of sudden transient disturbances. However, the discontinuity-induced Gibbs' phenomenon makes HHT analysis inaccurate around the two data ends. On the other hand, the SWF analysis has no Gibbs' phenomenon at the two data ends, but it cannot extract accurate modulation frequencies due to the use of non-orthogonal basic functions in the sliding-window least-squares curve-fitting process. Numerical and experimental results show that HHT can provide accurate extraction of intrawave amplitude- and phase-modulation, distorted harmonic response under a single-frequency harmonic excitation, softening and hardening effects, different orders of nonlinearity, interwave amplitude- and phasemodulation, multiple-mode vibrations caused by internal/external resonances, and instants of impact loading on a structure from stationary/transient responses. These phenomena are keys for performing dynamics-based structural damage detection and health monitoring.

  18. Evaluation of the Antioxidant and Melanogenesis Inhibitory Properties of Pracparatum Mungo (Lu-Do Huang)

    PubMed Central

    Kao, Yu-Yu; Chuang, Tien-Fu; Chao, Shiou-Huei; Yang, Jo-Hsuan; Lin, Yu-Chuan; Huang, Hui-Yu

    2013-01-01

    Pracparatum mungo (Lu-Do Huang) is a traditional Chinese functional medicine made from the natural fermentation of mung bean (Lǜ Dòu) mixed with other Chinese medicines. It has been recognized as having liver protecting and detoxifying effects. As mung beans have been verified to possess anti-inflammatory, antioxidant, antipyretic, and whitening actions, the present research utilized the in vitro, ex vivo, and in vivo experimental models to investigate the antioxidant and melanin inhibiting effects of P. mungo on the skin. The in vitro experiment revealed that P. mungo methanol extract (PMME) and P. mungo ethanol extract (PMEE) possess the capacity to clear α,α-diphenyl-2-picrylhydrazyl (DPPH) radicals and inhibit tyrosinase activity. The ex vivo experiment indicated that PMEE can promote the growth of MDCK cells and increase the enzymatic activities of superoxide dismutase (SOD) and catalase in MDCK cells. On the other hand, PMME and PMEE can suppress the proliferation of A375 cells, and PMEE can reduce the enzymatic activities of SOD and catalase in A375 cells. The in vivo results showed that P. mungo can enhance the enzymatic performance of SOD, Catalase, and glutathione peroxidase (GPx) in the liver. The results also showed that P. mungo has antioxidant characteristics and can inhibit tyrosinase activity, thereby promoting the growth of skin tissues and suppressing the proliferation of A375 cells, and thus enhancing the effects that the antioxidant enzymatic performance has on the liver. These results can be applied in the development of tyrosinase inhibitors or antioxidants used for the inhibition of melanin biosynthesis or for auto-oxidation in further industrial applications, particularly those relating to functional food or cosmetic compositions. PMID:24716173

  19. The protective effect of Liu-Wei-Di-Huang-Fang in salt-sensitive hypertension rats.

    PubMed

    Yang, Qiang; He, Yanming; Wang, Wenjian

    2014-01-01

    Abstract Hypertension is considered as a chronic and complex disease relating to multiple systemic systems. Apart from lowering blood pressure, the final purpose of the treatment lies in reducing the variability of blood pressure and other risk factors. Traditional Chinese medicine (TCM) has a long history of treating hypertension. This study was designed to determine the effect of Liu-Wei-Di-Huang-Fang (L-W-D-H-F), a compound used in traditional Chinese herbal medicine, to treat salt-sensitive hypertension (SSHT) induced by a high-salt and high-fat diet. L-W-D-H-F was prepared from six plant extracts. It was dissolved in 0.9% sodium chloride solution prior to use. Male Sprague-Dawley (6 weeks) rats were randomly divided into four groups: normal diet (CON); HSF (Without Drug Intervention); VAL (Valsartan 13.33 mg/kg/day); and LW (L-W-D-H-F 8.13 g/kg/day). Six weeks after blood pressure treatment, plasma biochemical analyses and histological and functional examination of the kidney were performed. L-W-D-H-F decreased the levels of mean arterial pressure (MAP), fasting blood glucose (FG), insulin (INS), high-density lipoprotein cholesterol (HDL-c), homeostasis model assessment of basal insulin resistance (HOMA-IR) and angiotensin II (Ang II) from plasma and Ang II and renin from kidney. It also promoted the excretion of urinary Na(+), reducing the loss of urinary K(+) and microalbuminuria (MAU), and improved the glomerular afferent arteriole, arterioles and each kidney unit. Together, these results suggest that L-W-D-H-F is capable of moderately reducing MAP in salt-sensitive hypertension and can work at different levels on multiple differential targets. PMID:24164386

  20. Analysis of natural mineral earthquake and blast based on Hilbert-Huang transform (HHT)

    NASA Astrophysics Data System (ADS)

    Li, Xuelong; Li, Zhonghui; Wang, Enyuan; Feng, Junjun; Kong, Xiangguo; Chen, Liang; Li, Baolin; Li, Nan

    2016-05-01

    There are important theoretical and scientific benefits to identify natural mineral earthquake and blast accurately to ensure the safety of mining. In the paper, we studied the wave characteristics of natural mineral earthquake and blast in a coal mine based on the Hilbert-Huang transform (HHT) method. Results show that the dominant frequency of natural mineral earthquake wave is 20 Hz, which is lower than the other frequency bands. The blast wave frequency is relatively complex and its dominant frequency is 140 Hz, which is higher than the other frequency bands. The natural mineral earthquake wave amplitude is 50 mV and the blast signal amplitude reaches up to 250 mV. However, the decay rate of natural mineral earthquake wave is slower than the blast wave. Both of them could be decomposed into 9 intrinsic mode functions (IMFs) by empirical mode decomposition (EMD). c2, c3, c4 and c5 are the main part of the natural mineral earthquake wave; while c2, c3, and c4 are the main part of the blast wave. These IMFs contain most of the signal energy and belong to the advantage part of the original signal. Besides, the instantaneous energy duration of natural mineral earthquake wave is longer, its peak energy arrival time is earlier and decay rate is slower, while the value is lower. The natural mineral earthquake wave Hilbert energy distributes in the sampling points 600-1200, frequency less than 50 Hz, and the energy peak 100 is at 25 Hz. By contrast, the blast wave Hilbert energy is concentrated on the sampling points 600-800, frequency around 50 Hz and 140 Hz, and the energy peak 170 is at 140 Hz.

  1. Number size distribution of aerosols at Mt. Huang and Nanjing in the Yangtze River Delta, China: Effects of air masses and characteristics of new particle formation

    NASA Astrophysics Data System (ADS)

    Wang, Honglei; Zhu, Bin; Shen, Lijuan; An, Junlin; Yin, Yan; Kang, Hanqing

    2014-12-01

    Aerosol number spectra in the range of 10 nm-10 μm were observed at Mt. Huang (Aug. 15-Sep. 15) and Nanjing (Oct. 13-Nov. 15) by a wide-range particle spectrometer (WPS) in 2011. Based on the backward trajectories obtained using the HYSPLIT model, the transport pathways of observed air masses during the study periods were classified into the following four groups: maritime air mass, continental air mass, marine-continental mixed air mass and local air mass. The variations in the aerosol number spectrum and the new particle formation (NPF) events for various types of air masses were discussed, along with meteorological data. The results showed that the average number concentration was 12,540 cm- 3 at Nanjing and only 2791 cm- 3 at Mt. Huang. The aerosol number concentration in Nanjing was 3-7 times higher than that in Mt. Huang; the large discrepancy was in the range of 10-100 nm. Different types of air masses had different effects on number concentration distribution. The number concentration of aerosols was higher in marine air masses, continental air masses and continental-marine mixed air masses at 10-50 nm, 100-500 nm and 50-200 nm, respectively. Under the four types of air masses, the aerosol size spectra had bimodal distributions in Nanjing and unimodal distributions in Mt. Huang (except under continental air masses: HT1). The effects of the diverse air masses on aerosol size segments of the concentration peak in Mt. Huang were stronger than those in Nanjing. The local air masses were dominant at these two sites and accounted for 44% of the total air masses. However, the aerosol number concentration was the lowest in Mt. Huang and the highest in Nanjing when local air masses were present. The number concentrations for foreign air masses increased at Mt. Huang and decreased at Nanjing. Different types of air masses had greater effects on the aerosol spectrum distribution at Mt. Huang than at Nanjing. During the NPF events, the particle growth rates at Mt. Huang (6.5-9.0 nm h- 1) were faster than those at Nanjing (4.8-5.6 nm h- 1). The relative humidity at Mt. Huang (36-65%) was higher than that at Nanjing (30-47%), but the wind speed trend was the opposite. The air masses during the NPF events were clean, i.e., they were mainly from over the ocean or districts with low ultrafine particle concentrations.

  2. Hilbert-Huang transform based instrumental assessment of intention tremor in multiple sclerosis

    NASA Astrophysics Data System (ADS)

    Carpinella, Ilaria; Cattaneo, Davide; Ferrarin, Maurizio

    2015-08-01

    Objective. This paper describes a method to extract upper limb intention tremor from gyroscope data, through the Hilbert-Huang transform (HHT), a technique suitable for the study of nonlinear and non-stationary processes. The aims of the study were to: (i) evaluate the method’s ability to discriminate between healthy controls and MS subjects; (ii) validate the proposed procedure against clinical tremor scores assigned using Fahn’s tremor rating scale (FTRS); and (iii) compare the performance of the HHT-based method with that of linear band-pass filters. Approach. HHT was applied on gyroscope data collected on 20 MS subjects and 13 healthy controls (CO) during finger-to-nose tests (FNTs) instrumented with an inertial sensor placed on the hand. The results were compared to those obtained after traditional linear filtering. The tremor amplitude was quantified with instrumental indexes (TIs) and clinical FTRS ratings. Main results. The TIs computed after HHT-based filtering discriminated between CO and MS subjects with clinically-detected intention tremor (MS_T). In particular, TIs were significantly higher in the final part of the movement (TI2) with respect to the first part (TI1), and, for all components (X, Y, Z), MST showed a TI2 significantly higher than in CO subjects. Moreover, the HHT detected subtle alterations not visible from clinical ratings, as TI2 (Z-component) was significantly increased in MS subjects without clinically-detected tremor (MS_NT). The method’s validity was demonstrated by significant correlations between clinical FTRS scores and TI2 related to X (rs = 0.587, p = 0.006) and Y (rs = 0.682, p < 0.001) components. Contrarily, fewer differences among the groups and no correlation between instrumental and clinical indexes emerged after traditional filtering. Significance. The present results supported the use of the HHT-based procedure for a fully-automated quantitative and objective measure of intention tremor in MS, which can overcome the limitations of clinical scales and provide supplementary information about this sign.

  3. Hilbert-Huang transform analysis of periodicities in the last two solar activity cycles

    NASA Astrophysics Data System (ADS)

    Kolotkov, D. Y.; Broomhall, A.-M.; Nakariakov, V. M.

    2015-08-01

    We investigated periodicities associated with the last two-and-a-half solar activity cycles with the novel Hilbert-Huang transform (HHT) method. Raw data signals of five different observational proxies: the 10.7 cm radio flux intensity, the helioseismic frequency shift, and the sunspot area signals recorded from the whole solar disc, and separately from the Northern and Southern hemispheres, were expanded into a set of intrinsic modes with the ensemble empirical mode decomposition technique. Instant and mean periods of each empirical mode were obtained with the use of the Hilbert transform applied independently to each separate mode. The periodicities were allocated to three distinct groups: short-term variations (with periods shorter than 0.5 yr), quasi-biennial oscillations (with typical periods from 0.5 yr to 3.9 yr), and longer periodicities, e.g. such as the 11 yr cycle. All periodicities detected in the examined solar cycles 22-24 are consistent with the well-known results found in the earlier solar epochs. We have demonstrated that the HHT method is a good tool for characterizing periodicities in the helioseismic data, which are necessarily relatively limited in terms of their time resolution. Periodicities obtained using the helioseismic data are, nevertheless, consistent with those found in other proxies. Since helioseismic oscillations are sensitive to the solar interior, this indicates that the behaviour of surface and atmospheric magnetic activity reflects that of the Sun's internal magnetic field. All identified intrinsic modes are seen to have clear amplitude modulation highly correlated with the 11 yr cycle. This amplitude modulation is most pronounced in the short-period modes. The short-term periodicities were found to be multiples of the shortest period, of 25 d. This ordering of the short-term periodicities is consistent with the previous findings. Signatures of the north-south asymmetry were detected in the individual hemisphere sunspot area indices. Furthermore, evidence of the last `extended' solar minimum was detected too.

  4. Utilizing Hilbert-Huang transform in detection some of mechanical properties of the refractory metals

    NASA Astrophysics Data System (ADS)

    Mohammed, Arshed Abdulhamed; Haris, Sallehuddin Mohamed; Nuawi, Mohd Zaki

    2016-02-01

    This study is one of the first to report on the use of Hilbert-Huang transform (HHT) to determine the modulus of elasticity of a material, which is one of the most important properties of metals. In addition, this study involves an analytical study of the process of transfer of energy, which was represented in the form of intrinsic mode functions (IMFs). Moreover, the distribution of IMFs within the time-frequency-plain was determined by testing eight test specimens. Five test specimens were refractory materials, namely, Ti, Ti6AL4V, Zr, Nb, and Ta, and the other three were non-refractory materials, namely, Al, Brass, and ST4340. The new setup was composed of Mg and involves the use of two piezoelectric transducers, which were used as the emitter and receiver. The setup was designed and implemented in this research based on Mg usage to test the metals. First, a new relationship was derived between the pressure transmission coefficient (PTC) of the transmitted wave (through the emitter-water-test specimen-Mg to the receiver) and the corresponding values of the product of the density (ρ) and the modulus of elasticity (E) for the same test specimen. Another relationship was established between the PTCs and the total energy transmitted at high frequencies. This energy indicates the summation of IMFs that have high frequencies (THIMFs), higher than 10 kHz, can determine E better than TOF for most test specimens. To verify this results, with regard to the second conclusion, a new simulation for this setup was carried out using Simulink in MATLAB. Twelve theoretical tests were done, for high acoustic impedance metals, like Hf, Mo, WNiFe and W in addition to test the same group which was tested experimentally. The results of theoretical tests supported the experimental results except for Nb. Most of the conclusions were obtained through practical results and analytical studies. The results proved that THIMFs can determine the change in the microstructure of the alloys when the ratio of their constituent elements was changed.

  5. Application of the Huang-Hilbert transform and natural time to the analysis of seismic electric signal activities.

    PubMed

    Papadopoulou, K A; Skordas, E S

    2014-12-01

    The Huang method is applied to Seismic Electric Signal (SES) activities in order to decompose them into their components, named Intrinsic Mode Functions (IMFs). We study which of these components contribute to the basic characteristics of the signal. The Hilbert transform is then applied to the IMFs in order to determine their instantaneous amplitudes. The results are compared with those obtained from the analysis in a new time domain termed natural time, after having subtracted the magnetotelluric background from the original signal. It is shown that these instantaneous amplitudes, when combined with the natural time analysis, can be used for the distinction of SES from artificial noises. PMID:25554022

  6. Study of nonlinear oscillations in a glow discharge plasma using empirical mode decomposition and Hilbert Huang transform

    SciTech Connect

    Wharton, A. M.; Sekar Iyengar, A. N.; Janaki, M. S.

    2013-02-15

    Hilbert Huang transform (HHT) based time series analysis was carried out on nonlinear floating potential fluctuations obtained from hollow cathode glow discharge plasma in the presence of anode glow. HHT was used to obtain contour plots and the presence of nonlinearity was studied. Frequency shift with time, which is a typical nonlinear behaviour, was detected from the contour plots. Various plasma parameters were measured and the concepts of correlation coefficients and the physical contribution of each intrinsic mode function have been discussed. Physically important quantities such as instantaneous energy and their uses in studying physical phenomena such as intermittency and non-stationary data have also been discussed.

  7. Application of the Huang-Hilbert transform and natural time to the analysis of seismic electric signal activities

    SciTech Connect

    Papadopoulou, K. A.; Skordas, E. S.

    2014-12-01

    The Huang method is applied to Seismic Electric Signal (SES) activities in order to decompose them into their components, named Intrinsic Mode Functions (IMFs). We study which of these components contribute to the basic characteristics of the signal. The Hilbert transform is then applied to the IMFs in order to determine their instantaneous amplitudes. The results are compared with those obtained from the analysis in a new time domain termed natural time, after having subtracted the magnetotelluric background from the original signal. It is shown that these instantaneous amplitudes, when combined with the natural time analysis, can be used for the distinction of SES from artificial noises.

  8. Residence time analysis of photochemical buildup of ozone in central eastern China from surface observation at Mt. Tai, Mt. Hua, and Mt. Huang in 2004.

    PubMed

    Pochanart, Pakpong

    2015-09-01

    Using data from surface observation, backward trajectories, and residence time analysis, the amounts of regional photochemical ozone buildup due to the large-scale anthropogenic sources in central eastern China (CEC, 30.5-40.5 N, 112.5-122.5 E) at Mt. Tai, Mt. Hua, and Mt. Huang in 2004 were quantified. It was found that the CEC anthropogenic sources influenced the air masses and the associated ozone production most at Mt. Tai, located at the center of CEC domain. At Mt. Hua to the west of CEC domain and at Mt. Huang to the south of CEC domain, the air masses and the associated ozone production showed less CEC anthropogenic influences on a regional scale. At Mt. Tai and Mt. Huang, the ozone mixing ratios in the air masses that passed over polluted source regions in CEC increased during the first 40-70 h after arrival and showed the highest production rate of 31.2 and 12.2 ppb/day, respectively, in May and June. It was estimated that the CEC anthropogenic sources contributed 34-42% of ozone at Mt. Tai and 8-14% at Mt. Huang during this ozone peak season. The large contributions from CEC sources during fall season (Sep-Nov) were also estimated as 31-44 and 17-23% but with the lower ozone production rate of 22.6 and 8.4 ppb/day, respectively, for Mt. Tai and Mt. Huang. PMID:25960018

  9. Effects of Huang Bai (Phellodendri Cortex) and Three Other Herbs on GnRH and GH Levels in GT1–7 and GH3 Cells

    PubMed Central

    Lee, Sun Haeng; Kwak, Sung Chul; Kim, Dong Kwan; Park, Sang Woug; Kim, Hyun Soo; Kim, Young-Sik; Lee, Donghun; Lee, Ju Won; Lee, Chang Gon; Lee, Hae Kyung; Cho, Sung-Min; Shin, Yu Jeong; Lee, Jin Yong; Kim, Hocheol; Chang, Gyu Tae

    2016-01-01

    The present study was to evaluate the effects of Huang Bai, Zhi Mu, Mai Ya, and Xia Ku Cao on hormone using the GT1–7 and GH3 cells. The GT1–7 and GH3 cell lines were incubated with DW; DMSO; and 30, 100, or 300 μg/mL of one of the four extract solutions in serum-free media for 24 hours. The MTT assay was performed to determine the cytotoxicity of the four herbs. The GT1–7 and GH3 cells were incubated in DW, estradiol (GT1–7 only), or noncytotoxic herb solutions in serum-free medium for 24 hours. A quantitative RT-PCR and western blot were performed to measure the GnRH expression in GT1–7 cells and GH expression in GH3 cells. Huang Bai, Zhi Mu, Xia Ku Cao, and Mai Ya inhibited the GnRH mRNA expression in GT1–7 cells, whereas Huang Bai enhanced GH mRNA expression in GH3 cells. Additionally, Xia Ku Cao inhibited GnRH protein expression in GT1–7 cells and Huang Bai promoted GH protein expression in GH3 cells. The findings suggest that Huang Bai can delay puberty by inhibiting GnRH synthesis in the hypothalamus while also accelerating growth by promoting GH synthesis and secretion in the pituitary. PMID:26925153

  10. Hilbert–Huang transform in detecting and analyzing the uterine contraction activities

    PubMed Central

    Aydın, Kemal; Demirer, Murat; Bayrak, Coşkun

    2015-01-01

    Objective The diagnosis of labor is currently one of the most difficult problems encountered by obstetrical healthcare providers. A major health problem is the increase in the rate of preterm delivery, which is responsible for 75% of all deaths in newborns. In addition, preterm delivery is associated with several cognitive and health problems in later life and enormous costs for the health system. A better understanding of myometrial activities could help to reduce preterm deliveries and the costs associated with prematurity in the following years. Therefore, the objective of this study was to determine whether using the Hilbert–Huang transform (HHT) to analyze the uterine contraction data would help us gain a better insight of the myometrial activities of the human uterus during pregnancy. Material and Methods Uterine magnetomyographic (MMG) signals were recorded from pregnant patients at gestational ages of 32–38 weeks. The study was approved by the Human Research Advisory Board of the University of Arkansas for Medical Sciences (UAMS) and performed after obtaining written consent from each patient. The recording of transabdominal MMG signals was conducted with the SQUID Array for Reproductive Assessment (SARA, VSM MedTech Inc; Coquitlam, BC, Canada) system, which has 151 primary magnetic sensors allocated approximately 3 cm apart over an area of 850 cm2. The arrangement of sensors is concave in nature and, in a similar lateral distance, spans the maternal abdomen longitudinally from the symphysis pubis to the uterine fundus. The recording times ranged from 12 to 28 min, and the sampling rate was 250 Hz. The data were down-sampled to 25 Hz to reduce the computational complexity and post-processed with a bandpass filter (0.05–1 Hz) because the uterine contraction activity is a band-limited process (0.05–1 Hz). The recordings of one intrauterine pressure catheter (IUPC) dataset and two mother-perceived contraction datasets were compared with the HHT results, and HHT’s potential was explored through the development of a module and a series of experiments. The local energy and the instantaneous frequency derived from the intrinsic mode functions (IMFs) through HHT provide a full energy-frequency-time distribution of the data. Our objective was to determine whether HHT for each channel can help identify and localize contractions in the uterus. Human studies have been reviewed by the appropriate ethics committee and have therefore been performed in accordance with the ethical standards described in an appropriate version of the 1975 Declaration of Helsinki, as revised in 2000. Results After comparing the IUPC and other mother-perceived contraction (STIM) datasets with HHT results, we were able to visually detect contraction locations in the HHT-processed uterine signals. For verification and validation purposes, when we further analyzed the delay time between two signals, the mechanical activity (i.e., IUPC) following the electrical activity (i.e., magnetic signal) was observed. In conclusion, our experimentations using the method introduced here revealed that there is a 75% correlation between the results obtained by HHT and IUPC data. Conclusion This study compared uterine contractions and changes in the intrauterine pressure with results obtained by HHT. In addition, using IUPC data as a validation guide, we showed that the HHT approach can be used for noise removal. There is a need for time-saving and non-subjective automatic contraction detection in the field of prenatal examination. PMID:26692768

  11. On Hilbert-Huang Transform Based Synthesis of a Signal Contaminated by Radio Frequency Interference or Fringes

    NASA Technical Reports Server (NTRS)

    Kizhner, Semion; Shiri, Ron S.; Vootukuru, Meg; Coletti, Alessandro

    2015-01-01

    Norden E. Huang et al. had proposed and published the Hilbert-Huang Transform (HHT) concept correspondently in 1996, 1998. The HHT is a novel method for adaptive spectral analysis of non-linear and non-stationary signals. The HHT comprises two components: - the Huang Empirical Mode Decomposition (EMD), resulting in an adaptive data-derived basis of Intrinsic Mode functions (IMFs), and the Hilbert Spectral Analysis (HSA1) based on the Hilbert Transform for 1-dimension (1D) applied to the EMD IMF's outcome. Although paper describes the HHT concept in great depth, it does not contain all needed methodology to implement the HHT computer code. In 2004, Semion Kizhner and Karin Blank implemented the reference digital HHT real-time data processing system for 1D (HHT-DPS Version 1.4). The case for 2-Dimension (2D) (HHT2) proved to be difficult due to the computational complexity of EMD for 2D (EMD2) and absence of a suitable Hilbert Transform for 2D spectral analysis (HSA2). The real-time EMD2 and HSA2 comprise the real-time HHT2. Kizhner completed the real-time EMD2 and the HSA2 reference digital implementations respectively in 2013 & 2014. Still, the HHT2 outcome synthesis remains an active research area. This paper presents the initial concepts and preliminary results of HHT2-based synthesis and its application to processing of signals contaminated by Radio-Frequency Interference (RFI), as well as optical systems' fringe detection and mitigation at design stage. The Soil Moisture Active Passive (SMAP mission (SMAP) carries a radiometer instrument that measures Earth soil moisture at L1 frequency (1.4 GHz polarimetric - H, V, 3rd and 4th Stokes parameters). There is abundant RFI at L1 and because soil moisture is a strategic parameter, it is important to be able to recover the RFI-contaminated measurement samples (15% of telemetry). State-of-the-art only allows RFI detection and removes RFI-contaminated measurements. The HHT-based analysis and synthesis facilitates recovery of measurements contaminated by all kinds of RFI, including jamming [7-8]. The fringes are inherent in optical systems and multi-layer complex contour expensive coatings are employed to remove the unwanted fringes. HHT2-based analysis allows test image decomposition to analyze and detect fringes, and HHT2-based synthesis of useful image.

  12. Automated Flaw Detection Scheme For Cast Austenitic Stainless Steel Weld Specimens Using Hilbert Huang Transform Of Ultrasonic Phased Array Data

    SciTech Connect

    Khan, T.; Majumdar, Shantanu; Udpa, L.; Ramuhalli, Pradeep; Crawford, Susan L.; Diaz, Aaron A.; Anderson, Michael T.

    2012-01-01

    The objective of this work is to develop processing algorithms to detect and localize the flaws using NDE ultrasonic data. Data was collected using cast austenitic stainless steel (CASS) weld specimens on-loan from the U.S. nuclear power industry’s Pressurized Water Reactor Owners Group (PWROG) specimen set. Each specimen consists of a centrifugally cast stainless steel (CCSS) pipe section welded to a statically cast (SCSS) or wrought (WRSS) section. The paper presents a novel automated flaw detection and localization scheme using low frequency ultrasonic phased array inspection signals in the weld and heat affected zone of the base materials. The major steps of the overall scheme are preprocessing and region of interest (ROI) detection followed by the Hilbert Huang transform (HHT) of A-scans in the detected ROIs. HHT offers time-frequency-energy distribution for each ROI. The accumulation of energy in a particular frequency band is used as a classification feature for the particular ROI.

  13. [Realization of Heart Sound Envelope Extraction Implemented on LabVIEW Based on Hilbert-Huang Transform].

    PubMed

    Tan, Zhixiang; Zhang, Yi; Zeng, Deping; Wang, Hua

    2015-04-01

    We proposed a research of a heart sound envelope extraction system in this paper. The system was implemented on LabVIEW based on the Hilbert-Huang transform (HHT). We firstly used the sound card to collect the heart sound, and then implemented the complete system program of signal acquisition, pretreatment and envelope extraction on LabVIEW based on the theory of HHT. Finally, we used a case to prove that the system could collect heart sound, preprocess and extract the envelope easily. The system was better to retain and show the characteristics of heart sound envelope, and its program and methods were important to other researches, such as those on the vibration and voice, etc. PMID:26211237

  14. On the origin of bistability in the Stage 2 of the Huang-Ferrell model of the MAPK signaling

    NASA Astrophysics Data System (ADS)

    Hada?, O.; Schreiber, I.; P?ibyl, M.

    2013-02-01

    Mitogen-activated protein kinases (MAPKs) are important signal transducing enzymes, unique to eukaryotes, that are involved in many pathways of cellular regulation. Successive phosphorylation cascades mediated by MAPKs serve as sensitive switches initiating various cellular processes. Apart from this basic feature, the underlying reaction network is capable of displaying other nonlinear phenomena including bistable steady states and hysteresis as well as periodic oscillations. We show that from the mechanistic point of view, bistability is a consequence of interaction between single and double phosphorylation/dephosphorylation pathways in a Stage 2 subsystem of the Huang-Ferrell model. Within this subsystem we uncover the core subnetwork obtained by systematic reduction relying on the methods of stoichiometric network analysis. For the core model we show that there is either one stable steady state or three steady states of which two are stable and point out the role of interplay between the single and double phosphorylation subnetworks in generating bistability.

  15. Effects of traditional Chinese herbal medicine San-Huang-Xie-Xin-Tang on gastrointestinal motility in mice

    PubMed Central

    Hwang, Min Woo; Ahn, Tae Seok; Hong, Noo Ri; Jeong, Han-Sol; Jung, Myeong Ho; Ha, Ki-Tae; Kim, Byung Joo

    2015-01-01

    AIM: To investigate the effects of San-Huang-Xie-Xin-Tang (SHXXT), a herbal product used in traditional Chinese medicine, on gastrointestinal (GI) motility in mice. METHODS: The in vivo effects of SHXXT on GI motility were investigated by measuring the intestinal transit rates (ITRs) using Evans blue in normal mice and in mice with experimentally induced GI motility dysfunction (GMD). RESULTS: In normal ICR mice, ITRs were significantly and dose-dependently increased by SHXXT (0.1-1 g/kg). GMD was induced by injecting acetic acid or streptozotocin intraperitoneally. The ITRs of GMD mice were significantly reduced compared to normal mice, and these reductions were significantly and dose-dependently inhibited by SHXXT (0.1-1 g/kg). CONCLUSION: These results suggest that SHXXT is a novel candidate for the development of a prokinetic agent that may prevent or alleviate GMD. PMID:25632184

  16. Shuang-Huang-Lian Attenuates Lipopolysaccharide-Induced Acute Lung Injury in Mice Involving Anti-Inflammatory and Antioxidative Activities

    PubMed Central

    Fang, Lei; Gao, Yuan; Liu, Fen; Hou, Rui; Cai, Run-Lan

    2015-01-01

    Shuang-Huang-Lian (SHL) is a common traditional Chinese preparation extracted from Lonicerae Japonicae Flos, Scutellariae Radix, and Fructus Forsythiae. In this study, we demonstrate the anti-inflammatory and antioxidative effects of SHL on lipopolysaccharide- (LPS-) induced acute lung injury (ALI) in mice. SHL reduced the lung wet/dry weight ratio, lowered the number of total cells in the bronchoalveolar lavage fluid, and decreased the myeloperoxidase activity in lung tissues 6?h after LPS treatment. It also inhibited the overproduction of proinflammatory cytokines (TNF-?, IL-1?, and IL-6) in the bronchoalveolar lavage fluid. Histological studies demonstrated that SHL attenuated LPS-induced interstitial edema, hemorrhage, and the infiltration of neutrophils into the lung tissue. Moreover, SHL could also enhance the superoxide dismutase and catalase activities, increase the reduced glutathione content, and decrease the malondialdehyde content. The present results suggest that SHL possesses anti-inflammatory and antioxidative properties that may protect mice against LPS-induced ALI. PMID:25945107

  17. Changes in extreme precipitation in the Huang-Huai-Hai River basin of China during 1960-2010

    NASA Astrophysics Data System (ADS)

    Zhang, Dong-Dong; Yan, Deng-Hua; Wang, Yi-Cheng; Lu, Fan; Wu, Di

    2015-04-01

    With the increasing exposure of populations and economy to the natural hazards, it is of vital importance to study the spatiotemporal characteristics of extreme precipitation. Based on daily precipitation at 154 meteorological stations in the Huang-Huai-Hai River basin of China during 1960-2010, the spatial and temporal changes in extreme precipitation were analyzed using twelve indices. The basin was divided into five climate areas using clustering analysis to detect the spatial changes of the extreme indices, and the temporal changes in the probability distributions of the extreme indices were also examined. The results showed that maximum 5-day precipitation, wet days and consecutive wet days decreased significantly while consecutive dry days showed a weak increasing trend. The other precipitation indices had insignificant decreasing trends. The probability distribution functions of simple daily intensity index and consecutive dry days were positively shifted while the rest of the indices were negatively shifted. The temporal changes of extreme indices implied that the frequency of extreme precipitation was decreasing, but the intensity of extreme precipitation was increasing in the Huang-Huai-Hai River basin. The spatial changes in the aspect of precipitation extreme events showed obvious spatial differences between different climate areas. In addition, the series including maximum 1-day precipitation and maximum 5-day precipitation were fitted by generalized extreme-value distribution for risk analysis and the results showed that the generalized extreme-value distribution could fit the series well. The amounts of extreme precipitation for different return periods were calculated and high risk areas for flooding disaster were presented.

  18. Impact of land-use induced changes on agricultural productivity in the Huang-Huai-Hai River Basin

    NASA Astrophysics Data System (ADS)

    Jin, Gui; Li, Zhaohua; Wang, Zhan; Chu, Xi; Li, Zhihui

    The water resource allocation is greatly influenced by the land use, agricultural productivity and farmers' income. Therefore analyzing the impacts of land use changes on agricultural productivity and subsequent effects on farmer's income is an important basis of the further study on the management mechanism and optimal water resource allocation. Taking the Huang-Huai-Hai River Basin as the study area, this study examined the impacts of conversion from cultivated land to built-up land from 2000-2005 and 2005-2008. Then the agricultural productivity was estimated with the Estimation System for Agricultural Productivity model, and the changes in agricultural productivity caused by land conversion were analyzed. Thereafter, Simultaneous Equations Model was used to analyze the impacts of the conversion from cultivated land to built-up land on the agricultural productivity and subsequent effects on farmer's income. The results showed that: (1) The agricultural productivity was stable during the whole period, reaching about 2.84 ton/ha, 3.09 ton/ha and 2.80 ton/ha on average in 2000, 2005 and 2008, respectively, but the conversion from cultivated land to built-up land had important influence on the spatial pattern of agricultural productivity. (2) The land productivity, total power of agricultural machinery and the conversion from cultivated land to built-up land had an overall positive effect on the agricultural productivity. (3) The agricultural productivity and gross domestic product had positive influence on the farmers' income, while the cultivated land area per capita and percentage of farming employee had negative influence, indicating that the farmer's income was mainly contributed by non-agricultural income. These results in this study showed that optimal land use management can play an important role in promoting virtuous ecosystem cycle and sustainable socioeconomic development, which can also lay an important foundation for further research on the optimal allocation of water resources in the Huang-Huai-Hai River Basin.

  19. Comprehensive quantitative analysis of Chinese patent drug YinHuang drop pill by ultra high-performance liquid chromatography quadrupole time of flight mass spectrometry.

    PubMed

    Wong, Tin-Long; An, Ya-Qi; Yan, Bing-Chao; Yue, Rui-Qi; Zhang, Tian-Bo; Ho, Hing-Man; Ren, Tian-Jing; Fung, Hau-Yee; Ma, Dik-Lung; Leung, Chung-Hang; Liu, Zhong-Liang; Pu, Jian-Xin; Han, Quan-Bin; Sun, Han-Dong

    2016-06-01

    YinHuang drop pill (YHDP) is a new preparation, derived from the traditional YinHuang (YH) decoction. Since drop pills are one of the newly developed forms of Chinese patent drugs, not much research has been done regarding the quality and efficacy. This study aims to establish a comprehensive quantitative analysis of the chemical profile of YHDP. ultra high-performance liquid chromatography quadrupole time of flight mass spectrometry (UHPLC-Q-TOF-MS/MS) was used to identify 34 non-sugar small molecules including 15 flavonoids, 9 phenolic acids, 5 saponins, 1 iridoid, and 4 iridoid glycosides in YHDP samples, and 26 of them were quantitatively determined. Sugar composition of YHDP in terms of fructose, glucose and sucrose was examined via a high performance liquid chromatography-evaporative light scattering detector on an amide column (HPLC-NH2P-ELSD). Macromolecules were examined by high performance gel permeation chromatography coupled with ELSD (HPGPC-ELSD). The content of the drop pill's skeleton component PEG-4000 was also quantified via ultra-high performance liquid chromatography coupled with charged aerosol detector (UHPLC-CAD). The results showed that up to 73% (w/w) of YHDP could be quantitatively determined. Small molecules accounted for approximately 5%, PEG-4000 represented 68%, while no sugars or macromolecules were found. Furthermore, YHDP showed no significant differences in terms of daily dosage, compared to YinHuang granules and YinHuang oral liquid; however, it has a higher small molecules content compared to YinHuang lozenge. PMID:27131804

  20. Correlation of black carbon aerosol and carbon monoxide in the high-altitude environment of Mt. Huang in Eastern China

    NASA Astrophysics Data System (ADS)

    Pan, X. L.; Kanaya, Y.; Wang, Z. F.; Liu, Y.; Pochanart, P.; Akimoto, H.; Sun, Y. L.; Dong, H. B.; Li, J.; Irie, H.; Takigawa, M.

    2011-09-01

    Understanding the relationship between black carbon (BC) and carbon monoxide (CO) will help improve BC emission inventories and the evaluation of global/regional climate forcing effects. In the present work, the BC (PM1) mass concentration and CO mixing ratio were continuously measured at a high-altitude background station on the summit of Mt. Huang (30.16° N, 118.26° E, 1840 m a.s.l.). Annual mean BC mass concentration was 1004.5 ± 895.5 ng m-3 with maxima in spring and autumn, and annual mean CO mixing ratio was 424.1 ± 159.2 ppbv. A large increase of CO was observed in the cold season, implying the contribution from the large-scale domestic coal/biofuel combustion for heating. The BC-CO relationship was found to show different seasonal features but strong positive correlation (R>0.8). In Mt. Huang area, the ΔBC/ΔCO ratio showed unimodal diurnal variations and had a maximum during the day (09:00-17:00 LST) and minimum at night (21:00-04:00 LST) in all seasons, indicating the impact of planetary boundary layer and the intrusion of clean air masses from the high troposphere. Back trajectory cluster analysis showed that the ΔBC/ΔCO ratio of plumes from the Eastern China (Jiangsu, Zhejiang provinces and Shanghai) was 8.8 ± 0.9 ng m-3 ppbv-1. Transportation and industry were deemed as controlling factors of the BC-CO relationship in this region. The ΔBC/ΔCO ratios for air masses from Northern China (Anhui, Henan, Shanxi and Shandong provinces) and southern China (Jiangxi, Fujian and Hunan provinces) were quite similar with mean values of 6.5 ± 0.4 and 6.5 ± 0.2 ng m-3 ppbv-1 respectively. The case studies combined with satellite observations demonstrated that the ΔBC/ΔCO ratio for biomass burning (BB) plumes were 10.3 ± 0.3 and 11.6 ± 0.5ng m-3 ppbv-1, significantly higher than those during non-BB impacted periods. The loss of BC during transport was also investigated on the basis of the ΔBC/ΔCO-RH (relative humidity) relationship along air mass pathways. The results showed that BC particles from Eastern China area was much more easily removed from atmosphere than other inland regions due to the higher RH along transport pathway, implying the importance of chemical compositions and mixing states on BC residence time in the atmosphere.

  1. Correlation of black carbon aerosol and carbon monoxide in the high-altitude environment of Mt. Huang in eastern China

    NASA Astrophysics Data System (ADS)

    Xiaole, P.; Kanaya, Y.; Wang, Z.

    2011-12-01

    Understanding the relationship between black carbon (BC) and carbon monoxide (CO) will help improve BC emission inventories and the evaluation of global/regional climate forcing effects. In the present work, the BC (PM1) and CO mixing ratio was continuously measured at a high-altitude background station on the summit of Mt. Huang (30.16° N, 118.26° E, 1840 m a.s.l.). Annual mean BC concentration was 1004.5 ± 895.5 ng/m3 with maxima in spring and autumn. The yearly averaged CO concentration was 424.1 ± 159.2 ppbv. The BC-CO relationship was found to show different seasonal features but strong positive correlation (R > 0.8). In Mt. Huang area, the ΔBC/ΔCO ratio showed unimodal diurnal variations and had a maximum during the day (0900-1700 LST) and minimum at night (2100-0400 LST) in all seasons, indicating the impact of planetary boundary layer and the intrusion of clean air masses from the high troposphere. Back trajectory cluster analysis showed that the ΔBC/ΔCO ratio of plumes from the Eastern China (Jiangsu, Zhejiang provinces and Shanghai) was 8.8 ± 0.9 ng/m3/ppbv. Transportation and industry were deemed as controlling factors of the BC-CO relationship in this region. The ΔBC/ΔCO ratios for air masses from northern China (Anhui, Henan, Shanxi and Shandong provinces) and southern China (Jiangxi, Fujian and Hunan provinces) were quite similar with mean values of 6.5 ± 0.4 and 6.5 ± 0.2 ng/m3/ppbv, respectively. The case studies combined with satellite observations demonstrated that the ΔBC/ΔCO ratio for biomass burning (BB) plume was 10.3±0.3~11.6±0.5ng/m3/ppbv. The ΔBC/ΔCO-RH relationship showed that BC particles from Eastern China was much more easily removed from atmosphere than other inland regions due to the higher RH along transport pathway, implying the importance of chemical compositions and mixing states on BC residence time in the atmosphere.

  2. Enhanced method to reconstruct mode shapes of continuous scanning measurements using the Hilbert Huang transform and the modal analysis method

    SciTech Connect

    Lee, Jongsuh; Hussain, Syed Hassaan; Wang, Semyung Park, Kyihwan

    2014-09-15

    Generally, it is time consuming to experimentally identify the operating deflection shape or mode shape of a structure. To overcome this problem, the Hilbert Huang transform (HHT) technique has been recently proposed. This technique is used to extract the mode shape from measurements that continuously measure the vibration of a region of interest within a structure using a non-contact laser sensor. In previous research regarding the HHT, two technical processes were needed to obtain the mode shape for each mode. The purpose of this study is to improve and complement our previous research, and for this purpose, a modal analysis approach is adapted without using the two technical processes to obtain an accurate un-damped impulse response of each mode for continuous scanning measurements. In addition, frequency response functions for each type of beam are derived, making it possible to make continuously scanned measurements along a straight profile. In this paper, the technical limitations and drawbacks of the damping compensation technique used in previous research are identified. In addition, the separation of resonant frequency (the Doppler effect) that occurs in continuous scanning measurements and the separation of damping phenomenon are also observed. The proposed method is quantitatively verified by comparing it with the results obtained from a conventional approach to estimate the mode shape with an impulse response.

  3. The Hilbert-Huang Transform-Based Denoising Method for the TEM Response of a PRBS Source Signal

    NASA Astrophysics Data System (ADS)

    Hai, Li; Guo-qiang, Xue; Pan, Zhao; Hua-sen, Zhong; Khan, Muhammad Younis

    2016-05-01

    The denoising process is critical in processing transient electromagnetic (TEM) sounding data. For the full waveform pseudo-random binary sequences (PRBS) response, an inadequate noise estimation may result in an erroneous interpretation. We consider the Hilbert-Huang transform (HHT) and its application to suppress the noise in the PRBS response. The focus is on the thresholding scheme to suppress the noise and the analysis of the signal based on its Hilbert time-frequency representation. The method first decomposes the signal into the intrinsic mode function, and then, inspired by the thresholding scheme in wavelet analysis; an adaptive and interval thresholding is conducted to set to zero all the components in intrinsic mode function which are lower than a threshold related to the noise level. The algorithm is based on the characteristic of the PRBS response. The HHT-based denoising scheme is tested on the synthetic and field data with the different noise levels. The result shows that the proposed method has a good capability in denoising and detail preservation.

  4. Nonlinear phase interaction between nonstationary signals: a comparison study of methods based on Hilbert-Huang and Fourier transforms.

    PubMed

    Lo, Men-Tzung; Novak, Vera; Peng, C-K; Liu, Yanhui; Hu, Kun

    2009-06-01

    Phase interactions among signals of physical and physiological systems can provide useful information about the underlying control mechanisms of the systems. Physical and biological recordings are often noisy and exhibit nonstationarities that can affect the estimation of phase interactions. We systematically studied effects of nonstationarities on two phase analyses including (i) the widely used transfer function analysis (TFA) that is based on Fourier decomposition and (ii) the recently proposed multimodal pressure flow (MMPF) analysis that is based on Hilbert-Huang transform (HHT)-an advanced nonlinear decomposition algorithm. We considered three types of nonstationarities that are often presented in physical and physiological signals: (i) missing segments of data, (ii) linear and step-function trends embedded in data, and (iii) multiple chaotic oscillatory components at different frequencies in data. By generating two coupled oscillatory signals with an assigned phase shift, we quantify the change in the estimated phase shift after imposing artificial nonstationarities into the oscillatory signals. We found that all three types of nonstationarities affect the performances of the Fourier-based and the HHT-based phase analyses, introducing bias and random errors in the estimation of the phase shift between two oscillatory signals. We also provided examples of nonstationarities in real physiological data (cerebral blood flow and blood pressure) and showed how nonstationarities can complicate result interpretation. Furthermore, we propose certain strategies that can be implemented in the TFA and the MMPF methods to reduce the effects of nonstationarities, thus improving the performances of the two methods. PMID:19658541

  5. Effects of the Chinese Herbal Formulation (Liu Wei Di Huang Wan) on the Pharmacokinetics of Isoflavones in Postmenopausal Women.

    PubMed

    Limopasmanee, Wirin; Chansakaow, Sunee; Rojanasthien, Noppamas; Manorot, Maleeya; Sangdee, Chaichan; Teekachunhatean, Supanimit

    2015-01-01

    A combination of soy isoflavones and Liu Wei Di Huang Wan (LWDHW) is potentially effective for postmenopausal women with intolerable vasomotor episodes who are not suitable candidates for hormonal therapy. The objective of this open-label, three-phase, crossover study was to determine the influence of both single and multiple oral doses of LWDHW on isoflavone pharmacokinetics in healthy postmenopausal women. Eleven subjects were assigned to receive the following regimens in a fixed sequence with washout periods of at least one week: Phase A, a single oral dose of soy milk; Phase B, a single oral dose of soy milk coadministered with LWDHW; and Phase C, multiple oral doses of LWDHW for 14 days followed by a single oral dose of soy milk. Blood samples were collected and mixed with β-glucuronidase/sulfatase to hydrolyze isoflavone conjugates to their respective aglycones (i.e., daidzein and genistein) and were determined using high performance liquid chromatography. The pharmacokinetic parameters analyzed were maximal plasma concentration (C max), time to reach peak concentration (T max), area under the plasma concentration-time curve (AUC), and half-life (t 1/2). The results found no statistically significant differences in pharmacokinetic parameters of daidzein and genistein among the three regimens. PMID:26146635

  6. The application of Hilbert-Huang transform in the analysis of muscle fatigue during cyclic dynamic contractions.

    PubMed

    Srhoj-Egekher, Vedran; Cifrek, Mario; Medved, Vladimir

    2011-06-01

    Surface electromyography (sEMG) is a common technique used in the assessment of local muscle fatigue. As opposed to static contraction situations, sEMG recordings during dynamic contractions are particularly characterised by non-stationary (and non-linear) features. Standard signal processing methods using Fourier and wavelet based procedures demonstrate well known restrictions on time-frequency resolution and the ability to process non-stationary and/or non-linear time-series, thus aggravating the spectral parameters estimation. The Hilbert-Huang transform (HHT), comprising of the empirical mode decomposition (EMD) and Hilbert spectral analysis (HSA), provides a new approach to overcome these issues. The time-dependent median frequency estimate is used as muscle fatigue indicator, and linear regression parameters are derived as fatigue quantifiers. The HHT method is utilised for the analysis of the sEMG signals recorded over quadriceps muscles during cyclic dynamic contractions. The results are compared with those obtained by the Fourier and wavelet based methods. It is shown that HHT procedure provides the most consistent and reliable assessment of spectral and derived linear regression parameters, given the time epoch width and sampling interval in the time domain. The suggested procedure successfully deals with non-stationary and non-linear properties of biomedical signals. PMID:21153059

  7. Effects of the Chinese Herbal Formulation (Liu Wei Di Huang Wan) on the Pharmacokinetics of Isoflavones in Postmenopausal Women

    PubMed Central

    Limopasmanee, Wirin; Chansakaow, Sunee; Rojanasthien, Noppamas; Manorot, Maleeya; Sangdee, Chaichan; Teekachunhatean, Supanimit

    2015-01-01

    A combination of soy isoflavones and Liu Wei Di Huang Wan (LWDHW) is potentially effective for postmenopausal women with intolerable vasomotor episodes who are not suitable candidates for hormonal therapy. The objective of this open-label, three-phase, crossover study was to determine the influence of both single and multiple oral doses of LWDHW on isoflavone pharmacokinetics in healthy postmenopausal women. Eleven subjects were assigned to receive the following regimens in a fixed sequence with washout periods of at least one week: Phase A, a single oral dose of soy milk; Phase B, a single oral dose of soy milk coadministered with LWDHW; and Phase C, multiple oral doses of LWDHW for 14 days followed by a single oral dose of soy milk. Blood samples were collected and mixed with β-glucuronidase/sulfatase to hydrolyze isoflavone conjugates to their respective aglycones (i.e., daidzein and genistein) and were determined using high performance liquid chromatography. The pharmacokinetic parameters analyzed were maximal plasma concentration (Cmax), time to reach peak concentration (Tmax), area under the plasma concentration-time curve (AUC), and half-life (t1/2). The results found no statistically significant differences in pharmacokinetic parameters of daidzein and genistein among the three regimens. PMID:26146635

  8. Anti-apoptotic effect of San Huang Shel Shin Tang cyclodextrin complex (SHSSTc) on CCl4 -induced hepatotoxicity in rats.

    PubMed

    Yang, Cheng-Hsun; Ting, Wei-Jen; Shen, Chia-Yao; Hsu, Hsi-Hsien; Lin, Yueh-Min; Kuo, Chia-Hua; Tsai, Fuu-Jen; Tsai, Chang-Hai; Tsai, Yuhsin; Huang, Chih-Yang

    2016-06-01

    The metabolic loading is heavier in liver especially when injured or inflammation. San Huang Shel Shin Tang (SHSST) was an old traditional herbal decoction, which composed with Rheum officinale Baill, Scutellaria baicalnsis Geprgi and Coptis chinensis Franch (1:1:2 in weight), can provide a liver protection effects. We used a beta-cyclodextrin (β-CD) drug modification method in reduce of the necessary dose of the SHSST. As the results, the FAS-FADD expressions leaded apoptosis in CCl4 intraperitoneal (IP) injection induced acute liver injury in rats. Silymarin, baicalein, SHSST, and SHSST β-CD complex (SHSSTc) pretreatments protected liver through the decreasing of the expressions of FAS-FADD and downstream caspase-3 and caspase-8. Particularly, SHSSTc (30 mg/kg day) treatment enhanced cell survival pathway activation through the PI3K, Akt and Bad phosphorylation. Compared with SHSST as well as silymarin and baicalein, SHSSTc provided a magnificent liver protection effect, especially in survival pathway activation/TUNEL-apoptotic cell reduction/serum cholesterol level suppression. All these data suggested that β-CD complex modified the SHSST and promoted the bioavailability and liver protection effects. © 2014 Wiley Periodicals, Inc. Environ Toxicol 31: 663-670, 2016. PMID:25447754

  9. Influence of signals length and noise in power spectral densities computation using Hilbert-Huang Transform in synthetic HRV

    NASA Astrophysics Data System (ADS)

    Rodríguez, María. G.; Altuve, Miguel; Lollett, Carlos; Wong, Sara

    2013-11-01

    Among non-invasive techniques, heart rate variability (HRV) analysis has become widely used for assessing the balance of the autonomic nervous system. Research in this area has not stopped and alternative tools for the study and interpretation of HRV, are still being proposed. Nevertheless, frequency-domain analysis of HRV is controversial when the heartbeat sequence is non-stationary. The Hilbert-Huang Transform (HHT) is a relative new technique for timefrequency analyses of non-linear and non-stationary signals. The main purpose of this work is to investigate the influence of time serieś length and noise in HRV from synthetic signals, using HHT and to compare it with Welch method. Synthetic heartbeat time series with different sizes and levels of signal to noise ratio (SNR) were investigated. Results shows i) sequencés length did not affect the estimation of HRV spectral parameter, ii) favorable performance for HHT for different SNR. Additionally, HHT can be applied to non-stationary signals from nonlinear systems and it will be useful to HRV analysis to interpret autonomic activity when acute and transient phenomena are assessed.

  10. Projection of extreme precipitation in the context of climate change in Huang-Huai-Hai region, China

    NASA Astrophysics Data System (ADS)

    Yin, Jun; Yan, Denghua; Yang, Zhiyong; Yuan, Zhe; Yuan, Yong; Zhang, Cheng

    2016-03-01

    Based on the national precipitation dataset (0.5∘×0.5∘) 1961-2011, published by the National Meteorological Information Center of China and the five Global Climate Models provided by ISI-MIP, annual maximum precipitation for 1 day, 3 days and 7 days could be calculated. Extreme precipitation was fitted via Generalized Extreme Value (GEV) distribution to explore the changes of extreme precipitation with the return period of 20 years and 50 years during 1961-2000 and 2001-2050. Based on this, extreme precipitation projection in Huang-Huai-Hai region was done. The results showed that the five Global Climate Models could simulate the statistical features of extreme precipitation quite well, in which IPSL-CM5A-LR has the highest precision. Simulation of IPSL-CM5A-LR indicates that precipitation with the return period of 20 years and 50 years in the middle reaches of the Yellow River, middle and lower reaches of Huaihe River and plain area of the southern Haihe River will increase considerably in the future. Extreme precipitation in some of the places will even increase by more than 30%, which means that these places will face larger flood risk and their capacity to respond to flood disasters should be improved.

  11. Network Pharmacology-Based Antioxidant Effect Study of Zhi-Zi-Da-Huang Decoction for Alcoholic Liver Disease

    PubMed Central

    An, Li; Feng, Fang

    2015-01-01

    Zhi-Zi-Da-Huang decoction (ZZDHD), a classic traditional Chinese medicine (TCM) formula, has been used for centuries to treat alcoholic liver disease. Reliable therapeutics of ZZDHD has also been validated in clinical practice. In this study, molecular docking and network analysis were carried out to explore the antioxidative mechanism of ZZDHD as an effective therapeutic approach to treat alcoholic liver disease. Multiple active compounds of ZZDHD were screened based on four key original enzymes (cytochrome P450 2E1, xanthine oxidase, inducible nitric oxide synthase, and cyclooxygenase-2) involved in ethanol-induced oxidative stress damage. A drug-target network was constructed through network pharmacology analysis, which predicted the relationships of active ingredients to the targets. Some results had been verified by the previous experimental pharmacological studies; meanwhile, it was first reported that xanthine oxidase and eriocitrin, neoeriocitrin, isorhoifolin, and poncirin had interactions. The network pharmacology strategy used provided a forceful tool for searching the mechanism of action of TCM formula and novel bioactive ingredients. PMID:25922610

  12. [Diversity of soil fauna in corn fields in Huang-Huai-Hai Plain of China under effects of conservation tillage].

    PubMed

    Zhu, Qiang-Gen; Zhu, An-Ning; Zhang, Jia-Bao; Zhang, Huan-Chao; Huang, Ping; Zhang, Cong-Zhi

    2009-10-01

    An investigation was made on the abundance and diversity of soil fauna in the corn fields under conventional and conservation tillage in Huang-Huai-Hai Plain of China. The abundance and diversity of soil fauna were higher at corn maturing (September) than at its jointing stage (July), and higher at jointing stage under conservation tillage than under conventional tillage. Soil fauna mainly distributed in surface soil layer (0-10 cm), but still had a larger number in 10-20 cm layer under conservation tillage. The individuals of acari, diptera, diplura, and microdrile oligochaetes, especially those of acari, were higher under conservation tillage than under conventional tillage. At maturing stage, an obvious effect of straw-returning under conservation tillage was observed, i. e., the more the straw returned, the higher the abundance of soil fauna, among which, the individuals of collembola, acari, coleopteran, and psocoptera, especially those of collembolan, increased significantly. The abundance of collembola at both jointing and maturing stages was significantly positively correlated with the quantity of straw returned, suggesting that collembola played an important role in straw decomposition and nutrient cycling. PMID:20077699

  13. Characterization of gear faults in variable rotating speed using Hilbert-Huang Transform and instantaneous dimensionless frequency normalization

    NASA Astrophysics Data System (ADS)

    Wu, T. Y.; Chen, J. C.; Wang, C. C.

    2012-07-01

    The objective of this research is to investigate the feasibility of utilizing the instantaneous dimensionless frequency (DLF) normalization and Hilbert-Huang Transform (HHT) to characterize the different gear faults in case of variable rotating speed. The normalized DLF of the vibration signals are calculated based on the rotating speed of shaft and the instantaneous frequencies of Intrinsic Mode Functions (IMFs) which are decomposed by Empirical Mode Decomposition (EMD) process. The faulty gear features on DLF-energy distribution of vibration signal can be extracted without the presence of shaft rotating speed, so that the proposed approach can be applied for characterizing the malfunctions of gearbox system under variable shaft rotating speed. A test rig of gear transmission system is performed to illustrate the gear faults, including worn tooth, broken tooth and gear unbalance. Different methods to determine the instantaneous frequency are employed to verify the consistence of characterization results. The DLF-energy distributions of vibration signals are investigated in different faulty gear conditions. The analysis results demonstrate the capability and effectiveness of the proposed approach for characterizing the gear malfunctions at the DLFs corresponding to the meshing frequency as well as the shaft rotating frequency. The support vector machine (SVM) is then employed to classify the vibration patterns of gear transmission system at different malfunctions. Using the energy distribution at the characteristic DLFs as the features, the different fault types of gear can be identified by SVM with high accuracy.

  14. Characterization of chemical constituents in Zhi-Zi-Da-Huang decoction by ultra high performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry.

    PubMed

    Zhu, Heyun; Yin, Ran; Han, Fei; Guan, Jiao; Zhang, Xiaoshu; Mao, Xinjuan; Zhao, Longshan; Li, Qing; Hou, Xiaohong; Bi, Kaishun

    2014-12-01

    A sensitive and reliable ultra high performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry method was established to separate and identify the chemical constituents of Zhi-Zi-Da-Huang decoction, a classic traditional Chinese medicine formula. The chromatographic separation was achieved on a Shim-pack XR-ODS C18 column (75 × 3.0 mm, 2.2 μm) using a gradient elution program. The detection was performed on a Waters Xevo G2 Q-TOF mass spectrometer equipped with electrospray ionization source in both positive and negative modes. With the optimized conditions, a total of 82 compounds were identified or tentatively characterized. Of the 82 compounds, 21 compounds were identified by comparing the retention time and MS data with reference standards, the rest were characterized by analyzing MS data and retrieving the reference literature. In addition, 31 compounds were identified from Gardenia jasminoides Ellis, ten compounds were identified from Rheum palmatum L., 33 compounds were identified from Citrus aurantium L., and eight compounds were identified from Sojae Semen Praeparatum. Results indicated that iridoids, anthraquinones, flavonoids, isoflavonoids, coumarins, glycosides of crocetin, monoterpenoids, and organic acids were major constituents in Zhi-Zi-Da-Huang decoction. It is concluded that the developed ultra high performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry method with high sensitivity and resolution is suitable for identifying and characterizing the chemical constituents of Zhi-Zi-Da-Huang decoction, and the analysis provides a helpful chemical basis for further research on Zhi-Zi-Da-Huang decoction. PMID:25195935

  15. Climate change impacts on agriculture and soil carbon sequestration potential in the Huang-Hai Plain of China

    SciTech Connect

    Thomson, Allison M.; Izaurralde, R Cesar C.; Rosenberg, Norman J.; He, Xiaoxia

    2006-03-01

    The Huang-Hai Plain in northeast China has been cultivated for thousands of years and is the most productive wheat growing region in the country. Its agricultural future will be determined in large part by how global climatic changes affect regional conditions and by the actions China takes to mitigate or adapt to climate change impacts. One potential mitigation strategy is to promote soil carbon (C) sequestration, which would improve soil quality while simultaneously contributing to the mitigation of climate change. The IPCC estimates that 40 Pg of C could be sequestered in cropland soils worldwide over the next century. Here we assess the potential for soil C sequestration with conversion of a conventional till (CT) continuous wheat system to a wheat-corn double cropping system and by implementing no till (NT) management for both continuous wheat and wheat-corn systems. To assess the influence of these management changes under a changing climate, we use two climate change scenarios at two time periods in the EPIC agro-ecosystem simulation model. The applied climate change scenarios are from the HadCM3 Global Climate Model for the time periods 2015-2045 and 2070-2099. The HadCM3 model projects that both temperature and precipitation will increase throughout the next century with increases of greater than 5 °C and up to 300 mm possible by 2099. An increase in the variability of temperature is also projected and is, accordingly, applied in the simulations. The EPIC model indicates that winter wheat yields would increase on average by 0.2 Mg ha-1 in the 2030 period and by 0.8 Mg ha-1 in the 2085 period due largely to the warmer nighttime temperatures and higher precipitation projected by the HadCM3 model. Simulated yields were not significantly affected by imposed changes in crop management. Simulated soil organic C content was higher under both NT management and double cropping than under CT continuous wheat. Soil C sequestration rates for continuous wheat systems were increased by 0.5 Mg ha-1 yr-1 by NT in the 2030 period and by 0.4 Mg ha-1 yr-1 in the 2085 period. With wheat-corn double cropping, NT increased sequestration rates by 1.3 and 1.0 Mg ha-1 yr-1 in 2030 and 2085, respectively. The total C offset due to a shift to NT management over 16 million hectares of agricultural land on the Huang-Hai Plain is 240 to 180 Tg C for continuous wheat management in 2030 and 2085, respectively and 675 to 495 Tg C for wheat-corn double cropping in 2030 and 2085, respectively.

  16. Plasma Metabolomic Profiling to Reveal Antipyretic Mechanism of Shuang-Huang-Lian Injection on Yeast-Induced Pyrexia Rats

    PubMed Central

    Peng, Long; Liu, Haiyu; Zhang, Li; Bai, Xu; Wang, Yingxin; Li, Jian; Cai, Chengke

    2014-01-01

    Shuang-huang-lian injection (SHLI) is a famous Chinese patent medicine, which has been wildly used in clinic for the treatment of acute respiratory tract infection, pneumonia, influenza, etc. The existing randomized controlled trial (RCT) studies suggested that SHLI could afford a certain anti-febrile action. However, seldom does research concern the pharmacological mechanisms of SHLI. In the current study, we explored plasma metabolomic profiling technique and selected potential metabolic markers to reveal the antipyretic mechanism of SHLI on yeast-induced pyrexia rat model using UPLC-Q-TOF/MS coupled with multivariate statistical analysis and pattern recognition techniques. We discovered a significant perturbance of metabolic profile in the plasma of fever rats and obvious reversion in SHLI-administered rats. Eight potential biomarkers, i.e. 1) 3-hydeoxybutyric acid, 2) leucine, 3) 16∶0 LPC, 4) allocholic acid, 5) vitamin B2, 6) Cys-Lys-His, 7) 18∶2 LPC, and 8) 3-hydroxychola-7, 22-dien-24-oic acid, were screened out by OPLS-DA approach. Five potential perturbed metabolic pathways, i.e. 1) valine, leucine, and isoleucine biosynthesis, 2) glycerophospholipid metabolism, 3) ketone bodies synthesis and degradation, 4) bile acid biosynthesis, and 5) riboflavin metabolism, were revealed to relate to the antipyretic mechanisms of SHLI. Overall, we investigated antipyretic mechanisms of SHLI at metabolomic level for the first time, and the obtained results highlights the necessity of adopting metabolomics as a reliable tool for understanding the holism and synergism of Chinese patent drug. PMID:24940599

  17. Characterizing Intermittency of 4-Hz Quasi-periodic Oscillation in XTE J1550-564 Using Hilbert-Huang Transform

    NASA Astrophysics Data System (ADS)

    Su, Yi-Hao; Chou, Yi; Hu, Chin-Ping; Yang, Ting-Chang

    2015-12-01

    We present time-frequency analysis results based on the Hilbert-Huang transform (HHT) for the evolution of a 4-Hz low-frequency quasi-periodic oscillation (LFQPO) around the black hole X-ray binary XTE J1550-564. The origin of LFQPOs is still debated. To understand the cause of the peak broadening, we utilized a recently developed time-frequency analysis, HHT, for tracking the evolution of the 4-Hz LFQPO from XTE J1550-564. By adaptively decomposing the ˜4-Hz oscillatory component from the light curve and acquiring its instantaneous frequency, the Hilbert spectrum illustrates that the LFQPO is composed of a series of intermittent oscillations appearing occasionally between 3 and 5 Hz. We further characterized this intermittency by computing the confidence limits of the instantaneous amplitudes of the intermittent oscillations, and constructed both the distributions of the QPO’s high- and low-amplitude durations, which are the time intervals with and without significant ˜4-Hz oscillations, respectively. The mean high-amplitude duration is 1.45 s and 90% of the oscillation segments have lifetimes below 3.1 s. The mean low-amplitude duration is 0.42 s and 90% of these segments are shorter than 0.73 s. In addition, these intermittent oscillations exhibit a correlation between the oscillation’s rms amplitude and mean count rate. This correlation could be analogous to the linear rms-flux relation found in the 4-Hz LFQPO through Fourier analysis. We conclude that the LFQPO peak in the power spectrum is broadened owing to intermittent oscillations with varying frequencies, which could be explained by using the Lense-Thirring precession model.

  18. Comprehensive quantitative analysis of Shuang-Huang-Lian oral liquid using UHPLC-Q-TOF-MS and HPLC-ELSD.

    PubMed

    Zhang, Tian-Bo; Yue, Rui-Qi; Xu, Jun; Ho, Hing-Man; Ma, Dik-Lung; Leung, Chung-Hang; Chau, Siu-Leung; Zhao, Zhong-Zhen; Chen, Hu-Biao; Han, Quan-Bin

    2015-01-01

    Shuang-Huang-Lian oral liquid (SHL) is a well-known Chinese patent drug containing three herbal medicines: Radix Scutellariae, Flos Lonicerae Japonicae and Fructus Forsythiae. It is usually used to treat acute upper respiratory tract infection caused by virus or bacteria. Although the licensing of botanical drug Veregen approved by FDA has indicated the importance of quantitative analysis in quality control of herbal medicines, quantitative evaluation of a Chinese patent drug like SHL remains a challenge due to the complex chemical profile. In this study, 15 small molecular components of SHL (four flavonoids, six quinic acid derivatives, three saponins and two phenylethanoid glycosides) were simultaneously determined using ultra-high performance liquid chromatography coupled with quadrupole-time-of-flight mass spectrometry (UHPLC-Q-TOF-MS). The contents of the three major saccharides, namely fructose, glucose and sucrose were quantified using high performance liquid chromatography-evaporative light scattering detector on an amino column (HPLC-ELSD). The macromolecules were quantified by precipitating in 80% ethanol, drying the precipitate, and then weighing. The established methods were validated in terms of linearity, sensitivity, precision, accuracy and stability and then successfully applied to analyze 12 batches of commercial products of SHL produced by four different manufacturers. The results indicated that 57.52-78.11% (w/w) of SHL could be quantitatively determined (non-saccharide small molecules: 1.77-3.75%, monosaccharides: 0.93-20.93%, macromolecules: 2.63-5.76% and sucrose: 49.20-65.94%). This study may provide a useful way to comprehensively evaluate the quality of SHL. PMID:25222137

  19. A Novel Characteristic Frequency Bands Extraction Method for Automatic Bearing Fault Diagnosis Based on Hilbert Huang Transform.

    PubMed

    Yu, Xiao; Ding, Enjie; Chen, Chunxu; Liu, Xiaoming; Li, Li

    2015-01-01

    Because roller element bearings (REBs) failures cause unexpected machinery breakdowns, their fault diagnosis has attracted considerable research attention. Established fault feature extraction methods focus on statistical characteristics of the vibration signal, which is an approach that loses sight of the continuous waveform features. Considering this weakness, this article proposes a novel feature extraction method for frequency bands, named Window Marginal Spectrum Clustering (WMSC) to select salient features from the marginal spectrum of vibration signals by Hilbert-Huang Transform (HHT). In WMSC, a sliding window is used to divide an entire HHT marginal spectrum (HMS) into window spectrums, following which Rand Index (RI) criterion of clustering method is used to evaluate each window. The windows returning higher RI values are selected to construct characteristic frequency bands (CFBs). Next, a hybrid REBs fault diagnosis is constructed, termed by its elements, HHT-WMSC-SVM (support vector machines). The effectiveness of HHT-WMSC-SVM is validated by running series of experiments on REBs defect datasets from the Bearing Data Center of Case Western Reserve University (CWRU). The said test results evidence three major advantages of the novel method. First, the fault classification accuracy of the HHT-WMSC-SVM model is higher than that of HHT-SVM and ST-SVM, which is a method that combines statistical characteristics with SVM. Second, with Gauss white noise added to the original REBs defect dataset, the HHT-WMSC-SVM model maintains high classification accuracy, while the classification accuracy of ST-SVM and HHT-SVM models are significantly reduced. Third, fault classification accuracy by HHT-WMSC-SVM can exceed 95% under a Pmin range of 500-800 and a m range of 50-300 for REBs defect dataset, adding Gauss white noise at Signal Noise Ratio (SNR) = 5. Experimental results indicate that the proposed WMSC method yields a high REBs fault classification accuracy and a good performance in Gauss white noise reduction. PMID:26540059

  20. A Novel Characteristic Frequency Bands Extraction Method for Automatic Bearing Fault Diagnosis Based on Hilbert Huang Transform

    PubMed Central

    Yu, Xiao; Ding, Enjie; Chen, Chunxu; Liu, Xiaoming; Li, Li

    2015-01-01

    Because roller element bearings (REBs) failures cause unexpected machinery breakdowns, their fault diagnosis has attracted considerable research attention. Established fault feature extraction methods focus on statistical characteristics of the vibration signal, which is an approach that loses sight of the continuous waveform features. Considering this weakness, this article proposes a novel feature extraction method for frequency bands, named Window Marginal Spectrum Clustering (WMSC) to select salient features from the marginal spectrum of vibration signals by Hilbert–Huang Transform (HHT). In WMSC, a sliding window is used to divide an entire HHT marginal spectrum (HMS) into window spectrums, following which Rand Index (RI) criterion of clustering method is used to evaluate each window. The windows returning higher RI values are selected to construct characteristic frequency bands (CFBs). Next, a hybrid REBs fault diagnosis is constructed, termed by its elements, HHT-WMSC-SVM (support vector machines). The effectiveness of HHT-WMSC-SVM is validated by running series of experiments on REBs defect datasets from the Bearing Data Center of Case Western Reserve University (CWRU). The said test results evidence three major advantages of the novel method. First, the fault classification accuracy of the HHT-WMSC-SVM model is higher than that of HHT-SVM and ST-SVM, which is a method that combines statistical characteristics with SVM. Second, with Gauss white noise added to the original REBs defect dataset, the HHT-WMSC-SVM model maintains high classification accuracy, while the classification accuracy of ST-SVM and HHT-SVM models are significantly reduced. Third, fault classification accuracy by HHT-WMSC-SVM can exceed 95% under a Pmin range of 500–800 and a m range of 50–300 for REBs defect dataset, adding Gauss white noise at Signal Noise Ratio (SNR) = 5. Experimental results indicate that the proposed WMSC method yields a high REBs fault classification accuracy and a good performance in Gauss white noise reduction. PMID:26540059

  1. Immuno-enhancement effects of Huang Qi Liu Yi Tang in a murine model of cyclophosphamide-induced leucopenia.

    PubMed

    Huang, Guan-Cheng; Wu, Lien-Sheng; Chen, Lih-Geeng; Yang, Ling-Ling; Wang, Ching-Chiung

    2007-01-19

    Tonic Chinese prescriptions are widely used in daily foods to improve health in Taiwan. Huang Qi Liu Yi Tang (HQLYT) is one such tonic Chinese prescription. In this study, the immuno-enhancement effects of HQLYT tonic were explored using an in vitro splenocyte proliferation assay and by evaluating improvements in cyclophosphamide-induced leucopenia in a BaLb/c mice model. HQLYT is composed of Radix Astragali, licorice, and jujube, and extracted in boiling water. The contents of glycyrrhizin and formononetin were used as bioactive markers to control the quality of the HQLYT water extract, at 7.26+/-0.04mg/g and 112.07+/-0.08 micro g/g, respectively. In the in vitro assay, HQLYT (12.5 micro g/ml) showed better immuno-enhancing effects than Radix Astragali, licorice, or jujube alone, and enhanced the survival rate of splenocytes by 88%. Moreover, HQLYT significantly enhanced the cytotoxic effects of natural killer cells of splenocytes against YAC-1 cells. The BaLb/c mice were fed HQLYT once a day for 14 days. After oral treatment with HQLYT 400mg/kg body weight (BW), the IL-2 release in BaLb/c mice and the natural killer cell activity of the splenocytes were both enhanced, and the WBC level of cyclophosphamide-induced leucopenic mice was improved by treatment with 400mg HQLYT/kgBW. HQLYT significantly delayed the decline in the WBC level and affected a faster recovery of the WBC level back to a normal status. In summary, HQLYT enhanced immunologic functions in both in vitro and in vivo studies. These results offer scientific evidence to prove the efficacy of this tonic Chinese prescription. PMID:16963213

  2. Plasma metabolomic profiling to reveal antipyretic mechanism of Shuang-huang-lian injection on yeast-induced pyrexia rats.

    PubMed

    Gao, Xiaoyan; Guo, Mingxing; Li, Qiang; Peng, Long; Liu, Haiyu; Zhang, Li; Bai, Xu; Wang, Yingxin; Li, Jian; Cai, Chengke

    2014-01-01

    Shuang-huang-lian injection (SHLI) is a famous Chinese patent medicine, which has been wildly used in clinic for the treatment of acute respiratory tract infection, pneumonia, influenza, etc. The existing randomized controlled trial (RCT) studies suggested that SHLI could afford a certain anti-febrile action. However, seldom does research concern the pharmacological mechanisms of SHLI. In the current study, we explored plasma metabolomic profiling technique and selected potential metabolic markers to reveal the antipyretic mechanism of SHLI on yeast-induced pyrexia rat model using UPLC-Q-TOF/MS coupled with multivariate statistical analysis and pattern recognition techniques. We discovered a significant perturbance of metabolic profile in the plasma of fever rats and obvious reversion in SHLI-administered rats. Eight potential biomarkers, i.e. 1) 3-hydeoxybutyric acid, 2) leucine, 3) 16:0 LPC, 4) allocholic acid, 5) vitamin B2, 6) Cys-Lys-His, 7) 18:2 LPC, and 8) 3-hydroxychola-7, 22-dien-24-oic acid, were screened out by OPLS-DA approach. Five potential perturbed metabolic pathways, i.e. 1) valine, leucine, and isoleucine biosynthesis, 2) glycerophospholipid metabolism, 3) ketone bodies synthesis and degradation, 4) bile acid biosynthesis, and 5) riboflavin metabolism, were revealed to relate to the antipyretic mechanisms of SHLI. Overall, we investigated antipyretic mechanisms of SHLI at metabolomic level for the first time, and the obtained results highlights the necessity of adopting metabolomics as a reliable tool for understanding the holism and synergism of Chinese patent drug. PMID:24940599

  3. Realgar, cinnabar and An-Gong-Niu-Huang Wan are much less chronically nephrotoxic than common arsenicals and mercurials.

    PubMed

    Lu, Yuan-Fu; Wu, Qin; Yan, Jun-Wen; Shi, Jing-Zhen; Liu, Jie; Shi, Jing-Shan

    2011-02-01

    Realgar (As(4)S(4)) and cinnabar (HgS) are frequently included in traditional Chinese medicines and Indian Ayurvedic medicines. Both As and Hg are well known for toxic effects, and their safety is of concern. The aim of this study was to compare chronic nephrotoxicity of An-Gong-Niu-Huang Wan (AGNH), realgar and cinnabar with common arsenicals and mercurials. Mice were orally administrated with AGNH (3 g/kg, 6-fold of clinical dose), cinnabar (0.3 g/kg, amount in AGNH) and realgar (0.3 g/kg, amount in AGNH), HgCl(2) (0.118 mmol/kg, 1/10 of cinnabar), MeHg (0.012 mmol/kg, 1/100 of cinnabar), NaAsO(2) (As(3+) 0.028 mmol/kg, 1/100 of realgar) or Na(2)HAsO(4) (As(5+) 0.056 mmol/kg, 1/50 of realgar), daily for six weeks, and nephrotoxicity was examined. Animal body weights were decreased by MeHg and HgCl(2). Blood urea nitrogen and creatinine levels were elevated by MeHg. Renal pathology was severe in the MeHg and HgCl(2) groups, moderate in the arsenite, arsenate and realgar groups and mild in the cinnabar and AGNH groups. Renal Hg accumulation in the MeHg and HgCl(2) groups was 50-200 folds higher than the cinnabar group. Expressions of metallothionein-1 and heme oxygenase-1, biomarkers for metal toxicity, were increased 2-5 folds by arsenite, arsenate, MeHg and HgCl(2), but not by realgar, cinnabar and AGNH. The chemokine and glutathione-S transferase-α4, markers for inflammation, were also increased by MeHg and HgCl(2). Expressions of cell adhesion gene S100a9 and E-cadherin were altered by HgCl(2), arsenite and realgar. Taken together, chemical forms of mercury and arsenic are major determinants in their disposition and toxicity. PMID:21321321

  4. Analysis of defects in externally driven dust-density wavefronts in cogenerated dusty plasma using the time-resolved Hilbert–Huang transform

    NASA Astrophysics Data System (ADS)

    Sarkar, Sanjib; Barman, Chiranjib; Mondal, Malay; Bose, M.; Mukherjee, S.

    2016-05-01

    Analysis of defects in externally driven dust-density wavefronts (DDWs) in cogenerated dusty plasma has been carried out. The DDWs are excited for threshold positive bias through another T-shaped electrode which is placed inbetween two main discharge electrodes. Spatiotemporal evolution of the DDWs reveals a wave defect and non-propagating wave mode in the DDW field. A space-time plot and the time-resolved Hilbert–Huang transform (HHT) were employed to analyze the spatiotemporal wave data at a specific location in the wave field.

  5. Size-resolved chemical composition of atmospheric particles during a straw burning period at Mt. Huang (the Yellow Mountain) of China

    NASA Astrophysics Data System (ADS)

    Chen, Kui; Yin, Yan; Kong, Shaofei; Xiao, Hui; Wu, Yixiao; Chen, Jianghua; Li, Aihua

    2014-02-01

    The particle size spectra and chemical composition of aerosol particles at Mt. Huang (the Yellow Mountain), a background site of southeastern China, were investigated using a single particle aerosol mass spectrometer (SPAMS) and other aerosol monitoring instruments. The field campaign was conducted from Sep. 29 to Oct. 9, 2012, to observe the influence of straw burning on the size distribution, chemical composition of atmospheric aerosols at a background site. Results showed that K-Secondary and K-EC particles were the dominant particle types during this period, with their number concentrations totally accounting for 74% of all the particles. From long-range transport analysis of air masses, six types of particles all contained high concentrations of 39 [K]+ ion (known as the tracer for biomass burning) which indicate that biomass burning may represent as a significant source of aerosols for air masses originated from the north of Mt. Huang. The sampling period could be classified into three sub-periods according to the backward trajectories. During sub-period 1, the K-Secondary particles exhibited the highest concentrations, accounting for 74.2% and 55.4%, respectively, of the submicron and super-micron particles. In sub-period 3, K-EC dominated the submicron particles, indicating that more particles had anthropogenic sources, especially industrial emissions. The results obtained in this study will enrich the database of aerosol chemical composition in the background sites of southeast China and could be of important applications in environmental and climate research.

  6. Low Level Jet Development - Investigating the Interaction of Different Scale Physical Processes with the use of the Hilbert - Huang Transform

    NASA Astrophysics Data System (ADS)

    Sgouros, G.; Helmis, C. G.

    2009-04-01

    The Low Level Jet (LLJ) is a common feature of the vertical structure of the Atmospheric Boundary Layer (ABL) that affects the meteorology and the local climate of an area, while it is important for aviation safety, wind energy and air quality applications. Low Level Jets have been associated mainly with the local topography and/or a large scale horizontal temperature contrast causing baroclinicity in the ABL, the diurnal heating cycle over sloping terrain, the mid-latitude fronts, the frontogenesis, the baroclinicity near coastal regions and the frictional decoupling. The purpose of this work is to investigate the interaction of the physical processes characterized by different time scales and identify the way they affect the characteristics and the evolution of the LLJ. The complex topographic features of the experimental area (Messogia Plain in Attica, Greece) and the vicinity with the sea, introduces, under favorable synoptic conditions, a variety of local circulations like land - sea breezes, katabatic and anabatic flows, phenomena that could provide a strong imprint on the wind components and affect the shape and behavior of LLJs. The selected event is a representative case of a post-frontal LLJ mainly observed during spring, summer and early autumn days at this area, characterized by clear skies or scattered cloudiness and strong diurnal temperature ranges. It is shown that these LLJ events are a result of the interaction of the synoptic scale with the local diurnal circulations which produces an oscillating core and highly fluxionary depth within the period of the diurnal cycle. In order to reveal the character of the observed wind variations during the LLJ event, the Hilbert-Huang Transform (HHT) algorithm is applied to SODAR wind speed data, at different levels. The HHT algorithm is an adaptive and empirically based data analysis method, well-suited for the study of intermittent and non-stationary processes that take place within the ABL. It consists of two steps of analysis. The first step, the Empirical Mode Decomposition (EMD), decomposes the original time series into a finite number of Intrinsic Mode Function (IMF) components, which represent the timescales that comprise the dataset. Then, the Hilbert transform (second step) is applied to each IMF to extract the instantaneous frequencies and amplitudes, as a function of time. The instantaneous frequency calculated by the Hilbert transform, should be understood as the frequency of a sine wave that locally fits the signal, rather than the frequency of a sine wave that is present throughout the entire time series signal. The analysis of this LLJ case showed that the moderate horizontal pressure gradient, the absence of cloudiness and the strong solar radiation provided a favorable environment for the development of the local flows. These flows interacted with the prevailing large scale wind field and significantly altered the shape of the synoptic LLJ introducing an oscillating core and variable depth. The use of the HHT algorithm provided a quantitative picture of the contribution of the various involved mechanisms. Inertial motions were mainly observed during the passage of the weak front, having a quite coherent vertical structure, while during the rest of the experimental period they exhibited much weaker amplitudes with an intermittent character. The diurnal cycle was found to be imprinted at the east - west wind component (u component) which is nearly parallel to the direction of the developed local flows, while the northerly component (v component) showed very weak diurnal variations. This was confirmed by the spectrum of the northerly component which was dominated by the synoptic forcing with periods from 4 to 8 days. The synoptic forcing is the physical process that controls the variations of the v component, while the u component was mainly affected by the inertial - diurnal cycle (frontal passage - local flows).

  7. Automated flaw detection scheme for cast austenitic stainless steel weld specimens using Hilbert-Huang transform of ultrasonic phased array data

    SciTech Connect

    Khan, Tariq; Majumdar, Shantanu; Udpa, Lalita; Ramuhalli, Pradeep; Crawford, Susan; Diaz, Aaron; Anderson, Michael T.

    2012-05-17

    The objective of this work is to develop processing algorithms to detect and localize flaws using ultrasonic phased-array data. Data was collected on cast austenitic stainless stell (CASS) weld specimens onloan from the U.S. nuclear power industry' Pressurized Walter Reactor Owners Group (PWROG) traveling specimen set. Each specimen consists of a centrifugally cast stainless stell (CCSS) pipe section welded to a statically cst(SCSS) or wrought (WRSS) section. The paper presents a novel automated flaw detection and localization scheme using low frequency ultrasonic phased array inspection singals from the weld and heat affected zone of the based materials. The major steps of the overall scheme are preprocessing and region of interest (ROI) detection followed by the Hilbert-Huang transform (HHT) of A-scans in the detected ROIs. HHT offers time-frequency-energy distribution for each ROI. The Accumulation of energy in a particular frequency band is used as a classification feature for the particular ROI.

  8. Bogoliubov theory and Lee-Huang-Yang corrections in spin-1 and spin-2 Bose-Einstein condensates in the presence of the quadratic Zeeman effect

    SciTech Connect

    Uchino, Shun; Kobayashi, Michikazu; Ueda, Masahito

    2010-06-15

    We develop Bogoliubov theory of spin-1 and spin-2 Bose-Einstein condensates (BECs) in the presence of a quadratic Zeeman effect, and derive the Lee-Huang-Yang (LHY) corrections to the ground-state energy, pressure, sound velocity, and quantum depletion. We investigate all the phases of spin-1 and spin-2 BECs that can be realized experimentally. We also examine the stability of each phase against quantum fluctuations and the quadratic Zeeman effect. Furthermore, we discuss a relationship between the number of symmetry generators that are spontaneously broken and that of Nambu-Goldstone (NG) modes. It is found that in the spin-2 nematic phase there are special Bogoliubov modes that have gapless linear dispersion relations but do not belong to the NG modes.

  9. Automated flaw detection scheme for cast austenitic stainless stell weld specimens using Hilbert-Huang transform of ultrasonic phased array data

    NASA Astrophysics Data System (ADS)

    Khan, Tariq; Majumdar, Shantanu; Udpa, Lalita; Ramuhalli, Pradeep; Crawford, Susan; Diaz, Aaron; Anderson, Michael T.

    2012-05-01

    The objective of this work is to develop processing algorithms to detect and localize flaws using ultrasonic phased-array data. Data was collected on cast austenitic stainless stell (CASS) weld specimens onloan from the U.S. nuclear power industry' Pressurized Walter Reactor Owners Group (PWROG) traveling specimen set. Each specimen consists of a centrifugally cast stainless stell (CCSS) pipe section welded to a statically cst(SCSS) or wrought (WRSS) section. The paper presents a novel automated flaw detection and localization scheme using low frequency ultrasonic phased array inspection singals from the weld and heat affected zone of the based materials. The major steps of the overall scheme are preprocessing and region of interest (ROI) detection followed by the Hilbert-Huang transform (HHT) of A-scans in the detected ROIs. HHT offers time-frequency-energy distribution for each ROI. The Accumulation of energy in a particular frequency band is used as a classification feature for the particular ROI.

  10. Quality evaluation of commercial Huang-Lian-Jie-Du-Tang based on simultaneous determination of fourteen major chemical constituents using high performance liquid chromatography.

    PubMed

    Kwok, Ka-Yan; Xu, Jun; Ho, Hing-Man; Chen, Hu-Biao; Li, Min; Lang, Yan; Han, Quan-Bin

    2013-11-01

    Huang-Lian-Jie-Du-Tang (HLJDT), comprising Coptidis Rhizoma, Scutellariae Radix, Phellodendri Cortex and Gardeniae Fructus, is one of the commonly used Chinese medicine formulas for clearing heat and detoxifying. Quality control of the herbal complex like Chinese medicine formulas still remains a challenge. The successful approval of botanical drug Veregen by FDA indicated the importance of quantitative analysis in quality control of herbal medicines. In this study, an effective quantitative method based on conventional HPLC-DAD was developed for simultaneous determination of fourteen major ingredients (seven alkaloids, four flavonoids, three terpenes) in HLJDT. The established method was well validated in terms of linearity, sensitivity, precision, accuracy and stability and then successfully applied to quality evaluation of commercial HLJDT samples. The developed method can quantitatively determine up to 70% of the chemicals of commercial HLJDT sample and effectively revealed the significant variation in the quality of the commercial HLJDT samples collected from different locations. PMID:23973454

  11. Monitoring As and Hg variation in An-Gong-Niu-Huang Wan (AGNH) intermediates in a pilot scale blending process using laser-induced breakdown spectroscopy.

    PubMed

    Liu, Xiaona; Ma, Qun; Liu, Shanshan; Shi, Xinyuan; Zhang, Qiao; Wu, Zhisheng; Qiao, Yanjiang

    2015-12-01

    Laser-induced breakdown spectroscopy (LIBS) was used to assess the cinnabar and realgar blending of An-Gong-Niu-Huang Wan (AGNH) in a pilot-scale experiment, including the blending end-point. The blending variability of two mineral medicines, cinnabar and realgar, were measured by signal relative intensity changing rate (RICR) and moving window standard deviation (MWSD) based on LIBS. Meanwhile, relative concentration changing rate (RCCR) was obtained based on the reference method involving inductively coupled plasma optical emission spectrometry (ICP-OES). The LIBS result was consistent with ICP-OES at blending end-point determinations of both mineral medicines. Unlike the ICP-OES method, LIBS does not have an elaborate digestion procedure. LIBS is a promising and rapid technique to understand the blending process of Chinese Materia Medica (CMM) containing cinnabar and realgar. These results demonstrate the potential of LIBS in monitoring CMM pharmaceutical production. PMID:26162343

  12. Comprehensive identification of 125 multifarious constituents in Shuang-huang-lian powder injection by HPLC-DAD-ESI-IT-TOF-MS.

    PubMed

    Sun, Hongyang; Liu, Meixian; Lin, Zongtao; Jiang, Haixiu; Niu, Yanyan; Wang, Hong; Chen, Shizhong

    2015-11-10

    A high-performance liquid chromatography-diode array detector-electrospray ionization-ion trap-time of flight-mass spectrometry (HPLC-DAD-ESI-IT-TOF-MS) method was established for excellent separation and structural identification of constituents in Shuang-huang-lian powder injection (SHLPI). The typical ultraviolet absorptions, accurate empirical molecular formula and reasonable fragmentation mechanisms of these ingredients were used for their structural elucidation. In consequence, 125 constituents (33 phenolic acids, 29 flavonoids, 32 phenylethanoid glycosides, 15 iridoid glycosides, 8 lignans, 3 amino acids and 2 purines nucleosides, 2 quinoid glycosides and 1 alkylbenzene glycoside) were either unequivocally identified or tentatively characterized by comparing authentic standards or published data. The result showed that this study could provide valuable information for the quality control and further investigation of SHLPI formula. PMID:26177215

  13. Time-frequency analysis of VLF for seismic-ionospheric precursor detection: Evaluation of Zhao-Atlas-Marks and Hilbert-Huang Transforms

    NASA Astrophysics Data System (ADS)

    Skeberis, C.; Zaharis, Z. D.; Xenos, T. D.; Spatalas, S.; Arabelos, D. N.; Contadakis, M. E.

    2015-12-01

    This work investigates the application of two post-processing methods of extracting spectra from VLF signals in order to detect disturbances that could be attributed to seismic-ionospheric precursory phenomena. Although precursory phenomena have been investigated in detail in past studies, a different application of time-frequency analysis methods may produce distinct patterns, which reveal disturbances in the VLF spectra received from stations that are in the propagation path over preparation zones, and also pinpoint disturbances that could be attributed to seismic-ionospheric precursors. To this purpose, three different methods of post processing are compared. These are the Wavelet Transform as a benchmark method in the form of the Continuous Wavelet Transform, a noise-assisted variant of the Hilbert-Huang Transform and the Zhao-Atlas-Marks Distribution. Comparative diagrams are presented and the advantages and weaknesses of each method are presented.

  14. Assessing the impact of climate change on the crop potential productivity in Huang-Huai-Hai Plain in China based on crop model and GIS technique

    NASA Astrophysics Data System (ADS)

    Tian, Zhan; Lei, Xiaotu; Gao, Zhiqiang

    2007-09-01

    The climate is changing due to higher concentrations of greenhouse gases. If concentrations continue to increase, climate models project climate change will be more severe in this century, and with significant impacts on many human sectors, particularly agriculture. Agriculture is a fundamental production sector for society, especially for highly populated countries such as China. Huang Huai-Hai Plain is regarded as the bread basket of China. With only 7.7% water resources of the whole country, it produces 39.2% of national grain production and 32.4% of gross domestic product. According to government predictions, by 2030 this area will have a net population increase of 104 million, while its urbanization rate will be greater than 50%. The total irrigated area will reach about 20 million ha, with a net increase of 2 million ha/year. In this study, DSSAT a dynamic process crop growth model, has been calibrated and validated for current production at ten sites in the major winter wheat and summer maize-growing region of Huang-Huai-Hai Plain in China The IPCC SRES greenhouse gase emission scenarios A2 and B2 were used in the simulation, combining with the Regional Climate Model (PRICES) which provides long term present and future daily weather data. Using the regional crop model and GIS technologies, the crop productivity changes of two main crops winter wheat and summer maize were for simulated 2020s, 2050s and 2080s under both IPCC SRES A2 and B2 greenhouse gases emission scenarios. Simulation results indicated the possibility of significant impacts of climate change on crop production in this region, with marked differences between rainfed and irrigated production. In conclusion, this exercise successfully tested the applicability of standard climate change impact assessment methodology to an important production region of China.

  15. Dry Matter Production, Photosynthesis of Flag Leaves and Water Use in Winter Wheat Are Affected by Supplemental Irrigation in the Huang-Huai-Hai Plain of China.

    PubMed

    Man, Jianguo; Shi, Yu; Yu, Zhenwen; Zhang, Yongli

    2015-01-01

    Winter wheat is threatened by drought in the Huang-Huai-Hai Plain of China, thus, effective water-saving irrigation practices are urgently required to maintain its high winter wheat production. This study was conducted from 2012 to 2014 to determine how supplemental irrigation (SI) affected soil moisture, photosynthesis, and dry matter (DM) production of winter wheat by measuring the moisture in 0-20 cm (W2), 0-40 cm (W3), and 0-60 cm (W4) soil profiles. Rainfed (W0) and local SI practice (W1, irrigation with 60 mm each at jointing and anthesis) treatments were designed as controls. The irrigation amount for W3 was significantly lower than that for W1 and W4 but higher than that for W2. The soil relative water content (SRWC) in 0-40 cm soil profiles at jointing after SI for W3 was significantly lower than that for W1 and W4 but higher than that for W2. W3 exhibited lower SRWC in 100-140 and 60-140 cm soil profiles at anthesis after SI and at maturity, respectively, but higher root length density in 60-100 cm soil profiles than W1, W2 and W4. Compared with W1, W2 and W4, photosynthetic and transpiration rates and stomatal conductance of flag leaves for W3 were significantly greater during grain filling, particularly at the mid and later stages. The total DM at maturity, DM in grain and leaves, post-anthesis DM accumulation and its contribution to grain and grain filling duration were higher for W3. The 1000-grain weight, grain yield and water use efficiency for W3 were the highest. Therefore, treatment of increasing SRWC in the 0-40 cm soil profiles to 65% and 70% field capacities at jointing and anthesis (W3), respectively, created a suitable soil moisture environment for winter wheat production, which could be considered as a high yield and water-saving treatment in Huang-Huai-Hai Plain, China. PMID:26335019

  16. Dry Matter Production, Photosynthesis of Flag Leaves and Water Use in Winter Wheat Are Affected by Supplemental Irrigation in the Huang-Huai-Hai Plain of China

    PubMed Central

    Man, Jianguo; Shi, Yu; Yu, Zhenwen; Zhang, Yongli

    2015-01-01

    Winter wheat is threatened by drought in the Huang-Huai-Hai Plain of China, thus, effective water-saving irrigation practices are urgently required to maintain its high winter wheat production. This study was conducted from 2012 to 2014 to determine how supplemental irrigation (SI) affected soil moisture, photosynthesis, and dry matter (DM) production of winter wheat by measuring the moisture in 0–20 cm (W2), 0–40 cm (W3), and 0–60 cm (W4) soil profiles. Rainfed (W0) and local SI practice (W1, irrigation with 60 mm each at jointing and anthesis) treatments were designed as controls. The irrigation amount for W3 was significantly lower than that for W1 and W4 but higher than that for W2. The soil relative water content (SRWC) in 0–40 cm soil profiles at jointing after SI for W3 was significantly lower than that for W1 and W4 but higher than that for W2. W3 exhibited lower SRWC in 100–140 and 60–140 cm soil profiles at anthesis after SI and at maturity, respectively, but higher root length density in 60–100 cm soil profiles than W1, W2 and W4. Compared with W1, W2 and W4, photosynthetic and transpiration rates and stomatal conductance of flag leaves for W3 were significantly greater during grain filling, particularly at the mid and later stages. The total DM at maturity, DM in grain and leaves, post-anthesis DM accumulation and its contribution to grain and grain filling duration were higher for W3. The 1000-grain weight, grain yield and water use efficiency for W3 were the highest. Therefore, treatment of increasing SRWC in the 0–40 cm soil profiles to 65% and 70% field capacities at jointing and anthesis (W3), respectively, created a suitable soil moisture environment for winter wheat production, which could be considered as a high yield and water-saving treatment in Huang-Huai-Hai Plain, China. PMID:26335019

  17. Metabolomic Study of Collagen-Induced Arthritis in Rats and the Interventional Effects of Huang-Lian-Jie-Du-Tang, a Traditional Chinese Medicine

    PubMed Central

    Yue, Rongcai; Zhao, Ling; Hu, Yaohua; Jiang, Peng; Wang, Shuping; Xiang, Li; Liu, Wencong; Shan, Lei; Zhang, Weidong; Liu, Runhui

    2013-01-01

    Huang-Lian-Jie-Du-Tang (HLJDT) is a traditional Chinese medicine (TCM) with anti-inflammatory activity. The present study used a metabolomic approach based on LC-Q-TOF-MS to profile rheumatoid-arthritis- (RA-) related metabolic changes and to investigate the interventional mechanisms of HLJDT in collagen-induced arthritis rats. Forty male Wistar rats were randomly divided into five groups: (1) a model group, (2) a normal control group, (3) a dexamethasone group, (4) a HLJDT group, and (5) a group that received 13 components of HLJDT. Plasma samples were collected 8, 15, and 22 days after the rats were injected with bovine type II collagen. By combining variable importance in the projection values with partial least squares discriminant analysis, 18 potential biomarkers were identified in the plasma samples. The biomarkers were primarily involved in glycerophospholipid metabolism, fatty acid metabolism, tryptophan metabolism, linoleic acid metabolism, phenylalanine metabolism, purine metabolism, arachidonic acid metabolism, and bile acid biosynthesis. Using the potential biomarkers as a screening index, the results suggest that HLJDT can potentially reverse the process of RA by partially regulating fatty acid oxidation and arachidonic acid metabolism. This study demonstrates that a metabolomic strategy is useful for identifying potential RA biomarkers and investigating the underlying mechanisms of a TCM in RA treatment. PMID:23533484

  18. Preparation and in vitro aerosol performance of spray-dried Shuang-Huang-Lian corrugated particles in carrier-based dry powder inhalers.

    PubMed

    Yang, Jing-Jing; Liu, Chun-Yu; Quan, Li-Hui; Liao, Yong-Hong

    2012-09-01

    The development of dry powder inhalation (DPI) products of traditional Chinese medicine (TCM) remains to be a challenge due to chemical complexity and batch-to-batch variations in constituent composition. This study was to investigate the feasibility of using spray-dried corrugated particles to improve the aerodynamic performance of a TCM, Shuang-Huang-Lian (SHL), in carrier-based DPI. Particles with different surface roughness were spray-dried by the addition of leucine and concomitant manipulation of spray-drying parameters. The surface roughness was determined by atomic force microscopy, whilst the aerodynamic performance of drug particle-mannitol/lactose blends was evaluated using a next-generation pharmaceutical impactor through a Cyclohaler. Although the emission efficiency for corrugated particle-based DPI was ~10% lower than that for smooth SHL, the fine particle fractions (FPF(<4.4 μm)) of 32.4-36.8% for the former were significantly higher than those of 14.7-16.2% for the latter. In particular, the FPF and fraction of drug detached from the carrier appeared not to be significantly affected by the variation in constituent composition of SHL. This study demonstrates that the use of corrugated particles in carrier-based DPI improved aerosol performance by facilitating drug detachment from the carrier, independent of variation in constituent composition, and such particles were potentially applicable to the development of SHL DPI products. PMID:22644707

  19. Cross-correlation analysis and time delay estimation of a homologous micro-seismic signal based on the Hilbert-Huang transform

    NASA Astrophysics Data System (ADS)

    Sun, Hong-Mei; Jia, Rui-Sheng; Du, Qian-Qian; Fu, You

    2016-06-01

    A micro-seismic signal's transient features are non-stationary. The traditional weighted generalized cross-correlation (GCC) algorithm is based on the cross-power spectrum density. This algorithm diminishes the performance of the time delay estimation for homologous micro-seismic signals. This paper analyzed the influence of calculation error on the cross-power spectrum density of a non-stationary signal and proposed a new cross-correlation analysis and time delay estimation method for homologous micro-seismic signals based on the Hilbert-Huang transform (HHT). First, the original signals are decomposed into intrinsic mode function (IMF) components using empirical mode decomposition (EMD) for de-noising. Subsequently, the IMF components and the original signals are analyzed using a cross-correlation analysis. The IMF components are subsequently remodeled at different scales using the Hilbert transform. The marginal spectrum density is obtained via a time integration of the remodeled components. The cross-marginal spectrum density of the two signals can also be obtained. Finally, the cross-marginal spectrum density is used in the weighted GCC algorithm for time delay estimation instead of the cross-power spectrum density. The time delay estimation is determined by searching for the weighted GCC function peak. The experiments demonstrated the superior time delay estimation performance of the new method for non-stationary transient signals. Therefore, a new time delay estimation method for non-stationary random signals is presented in this paper.

  20. Simultaneous determination of various bioactive redox components in Shuang-Huang-Lian preparations using a novel three-channel isocratic elution liquid chromatography with electrochemical detection system.

    PubMed

    Chen, Liangmian; Hakamata, Hideki; Kusu, Fumiyo; Wang, Zhimin; Gao, Huimin; Kotani, Akira

    2014-07-01

    A novel three-channel isocratic elution high performance liquid chromatography with electrochemical detection (3LC-ECD) system was developed for the simultaneous determination of various bioactive redox components in Shuang-Huang-Lian (SHL) preparations. This 3LC-ECD system consists of three isocratic elution flow ways, two switching valves, four columns, and three electrochemical detectors. Through alternately rotating switching valves to change the elution flow way, six caffeoylquinic acids, four flavonoids, and one phenylethanoid glycoside compound were simultaneously determined within 70 min by the present 3LC-ECD method, in which three compounds of protocatechuic aldehyde, propyl gallate, and kaempferol were used as internal standards. The results demonstrated that the present 3LC-ECD method has achieved desired linearity (r>0.999), precision (relative standard deviation <2.5%), accuracy (recovery, 95.6-103.6%), and high sensitivity (limit of detection, 0.11-0.90 ng/mL). In addition, we successfully determined the contents of these 11 bioactive redox components in 14 batches of SHL oral liquid and 12 batches of SHL lyophilized powder for injection produced by different manufacturers in China. PMID:24657677

  1. Analysis and Recognition of Traditional Chinese Medicine Pulse Based on the Hilbert-Huang Transform and Random Forest in Patients with Coronary Heart Disease

    PubMed Central

    Guo, Rui; Wang, Yiqin; Yan, Hanxia; Yan, Jianjun; Yuan, Fengyin; Xu, Zhaoxia; Liu, Guoping; Xu, Wenjie

    2015-01-01

    Objective. This research provides objective and quantitative parameters of the traditional Chinese medicine (TCM) pulse conditions for distinguishing between patients with the coronary heart disease (CHD) and normal people by using the proposed classification approach based on Hilbert-Huang transform (HHT) and random forest. Methods. The energy and the sample entropy features were extracted by applying the HHT to TCM pulse by treating these pulse signals as time series. By using the random forest classifier, the extracted two types of features and their combination were, respectively, used as input data to establish classification model. Results. Statistical results showed that there were significant differences in the pulse energy and sample entropy between the CHD group and the normal group. Moreover, the energy features, sample entropy features, and their combination were inputted as pulse feature vectors; the corresponding average recognition rates were 84%, 76.35%, and 90.21%, respectively. Conclusion. The proposed approach could be appropriately used to analyze pulses of patients with CHD, which can lay a foundation for research on objective and quantitative criteria on disease diagnosis or Zheng differentiation. PMID:26180536

  2. Validation of crop model for simulating summer maize in the Huang-Huai Plain of China and its application on analyzing drought effects

    NASA Astrophysics Data System (ADS)

    Li, Shuyan; Liu, Ronghua; Cheng, Lin; Fang, Wensong; Wang, Xinli

    2009-08-01

    Using datasets of 1991-2004 meteorological and soil data as well as field management from 8 stations in the summer-sown maize zone over the Huang-Huai River Basin, North China, study is performed of the water deficit in various phases of growth of the crop impacting on the final yield by means of CERES-Maize of DSSAT Version 4.0, whose parameters are adjusted for local conditions. Results show that 1) in the jointing stage of vegetative growth and the filling stage (especially its earlier part) of the reproduction growth, field moisture acts as a key factor affecting the yield; 2) deficient moisture in the 7-leaf and jointing periods would cause maximum leaf area index to significantly drop, keeping dry matter from accumulation, leading to appreciable diminution of weight of dry stem and leaves; 3) water deficit in the earlier (middle) filling stage would result in reduced number of grains per cob (decrease substantially the weight of 100 grains). The findings in conjunction with measured moisture can be used to implement the "efficient irrigation with less water" practice in this vast region.

  3. Effect of Huai Qi Huang on Epithelial-Mesenchymal Transition of Renal Tubular Epithelial Cells through miR-200a

    PubMed Central

    Pu, Jinyun; Zhang, Yu; Zhou, Jianhua

    2016-01-01

    Epithelial-mesenchymal transition (EMT) of renal tubular epithelial cells is a vital mechanism of renal fibrosis. Mounting evidence suggests that miR-200a expression decreases in tubular epithelial cells in unilateral ureteral obstruction (UUO) rats. Moreover, it has been demonstrated that Huai Qi Huang (HQH) can ameliorate tubulointerstitial damage in adriamycin nephrosis and delay kidney dysfunction in primary glomerular disease. However, the effect of HQH on EMT of tubular epithelial cells in UUO rats and its molecular mechanism is unclear. In order to explore the effect of HQH on EMT and its molecular mechanism in renal fibrosis, in vitro and in vivo experiments were performed in our study. Our results showed that HQH increased miR-200a expression in UUO rats and in TGF-β1 stimulated NRK-52E cells. Meanwhile, HQH decreased ZEB1 and ZEB2 (the transcriptional repressors of E-cadherin), α-SMA expression in renal tubular epithelial cells in vitro and in vivo. Furthermore, we found that HQH protected kidney from fibrosis in UUO rats. The results demonstrated that HQH regulated miR-200a/ZEBs pathway and inhibited EMT process, which may be a mechanism of protecting effect on tubular cells in renal fibrosis. PMID:26884796

  4. Toxicology evaluation of realgar-containing niu-huang-jie-du pian as compared to arsenicals in cell cultures and in mice.

    PubMed

    Miao, Jia-Wei; Liang, Shi-Xia; Wu, Qin; Liu, Jie; Sun, An-Sheng

    2011-01-01

    Niu-Huang-Jie-Du Pian (NHJD) is a widely used traditional Chinese medicine containing realgar (As4S4). Realgar has been included in many traditional medicines, but is often taken as arsenite for risk assessment. To evaluate true risk of realgar and realgar-containing NHJD, their toxicity was compared with common arsenicals. In cultured cells, the LC50 for NHJD (1200 μM) and realgar (2000 μM) was much higher than arsenite(35 μM), arsenic trioxide (280 μM), and arsenate (400 μM). Acute toxicity in mice showed more severe liver and kidney injury after arsenite or arsenate, but was mild after realgar and NHJD, corresponding to cellular and tissue arsenic accumulation. The expressions of arsenic-sensitive stress gene metallothionein-1 were increased 3-7-folds after arsenite or arsenate, but were unaltered after NHJD and realgar. Thus, realgar and NHJD are much less toxic than arsenite and arsenate. The use of total arsenic to evaluate the safety of realgar and realgar-containing NHJD is inappropriate. PMID:23724280

  5. Functional Representation for the Born-Oppenheimer Diagonal Correction and Born-Huang Adiabatic Potential Energy Surfaces for Isotopomers of H3

    SciTech Connect

    Mielke, Steven L; Schwenke, David; Schatz, George C; Garrett, Bruce C; Peterson, Kirk A

    2009-04-23

    Multireference configuration interaction (MRCI) calculations of the Born-Oppenheimer diagonal correction (BODC) for H3 were performed at 1397 symmetry-unique configurations using the Born-Handy approach; isotopic substitution leads to 4041 symmetry-unique configurations for the DH2 mass combination. These results were then fit to a functional form that permits calculation of the BODC for any combination of isotopes. Mean unsigned fitting errors on a test grid of configurations not included in the fitting process were 0.14, 0.12, and 0.65 cm-1 for the H3, DH2, and MuH2 isotopomers, respectively. This representation can be combined with any Born-Oppenheimer potential energy surface (PES) to yield Born-Huang (BH) PESs; herein we choose the CCI potential energy surface, the uncertainties of which (~0.01 kcal/mol) are much smaller than the magnitude of the BODC. FORTRAN routines to evaluate these BH surfaces are provided. Variational transition state theory calculations are presented comparing thermal rate constants for reactions on the BO and BH surfaces to provide an initial estimate of the significance of the diagonal correction for the dynamics.

  6. Reconstruction of the in-plane mode shape of a rotating tire with a continuous scanning measurement using the Hilbert-Huang transform

    NASA Astrophysics Data System (ADS)

    Lee, Jongsuh; Wang, Semyung; Pluymers, Bert; Desmet, Wim; Kindt, Peter

    2015-02-01

    Generally, the dynamic characteristics (natural frequency, damping, and mode shape) of a structure can be estimated by experimental modal analysis. Among these dynamic characteristics, mode shape requires multiple measurements of the structure at different positions, which increases the experimental cost and time. Recently, the Hilbert-Huang transform (HHT) method has been introduced to extract mode-shape information from a continuous measurement, which requires vibration measurements from one position to another position continuously with a non-contact sensor. In this research study, an effort has been made to estimate the mode shapes of a rolling tire with a single measurement instead of using the conventional experimental setup (i.e., measurement of the vibration of a rolling tire at multiple positions similar to the case of a non-rotating structure), which is used to estimate the dynamic behavior of a rolling tire. For this purpose, HHT, which was used in the continuous measurement of a non-rotating structure in previous research studies, has been used for the case of a rotating system in this study. Ambiguous mode combinations can occur in this rotating system, and therefore, a method to overcome this ambiguity is proposed in this study. In addition, the specific phenomenon for a rotating system is introduced, and the effect of this phenomenon with regard to the obtained results through HHT is investigated.

  7. Reconstruction of the in-plane mode shape of a rotating tire with a continuous scanning measurement using the Hilbert-Huang transform.

    PubMed

    Lee, Jongsuh; Wang, Semyung; Pluymers, Bert; Desmet, Wim; Kindt, Peter

    2015-02-01

    Generally, the dynamic characteristics (natural frequency, damping, and mode shape) of a structure can be estimated by experimental modal analysis. Among these dynamic characteristics, mode shape requires multiple measurements of the structure at different positions, which increases the experimental cost and time. Recently, the Hilbert-Huang transform (HHT) method has been introduced to extract mode-shape information from a continuous measurement, which requires vibration measurements from one position to another position continuously with a non-contact sensor. In this research study, an effort has been made to estimate the mode shapes of a rolling tire with a single measurement instead of using the conventional experimental setup (i.e., measurement of the vibration of a rolling tire at multiple positions similar to the case of a non-rotating structure), which is used to estimate the dynamic behavior of a rolling tire. For this purpose, HHT, which was used in the continuous measurement of a non-rotating structure in previous research studies, has been used for the case of a rotating system in this study. Ambiguous mode combinations can occur in this rotating system, and therefore, a method to overcome this ambiguity is proposed in this study. In addition, the specific phenomenon for a rotating system is introduced, and the effect of this phenomenon with regard to the obtained results through HHT is investigated. PMID:25725889

  8. An Application of Hilbert-Huang Transform on the Non-Stationary Astronomical Time Series: The Superorbital Modulation of SMC X-1

    NASA Astrophysics Data System (ADS)

    Hu, Chin-Ping; Chou, Yi; Wu, Ming-Chya; Yang, Ting-Chang; Su, Yi-Hao

    2013-06-01

    We present the Hilbert-Huang transform (HHT) analysis on the quasi-periodic modulation of SMC X-1. SMC X-1, consisting of a neutron star and a massive companion, exhibits superorbital modulation with a period varying between ~40 d and ~65 d. We applied the HHT on the light curve observed by the All-Sky Monitor onboard Rossi X-ray Timing Explorer (RXTE) to obtain the instantaneous frequency of the superorbital modulation of SMC X-1. The resultant Hilbert spectrum is consistent with the dynamic power spectrum while it shows more detailed information in both the time and frequency domains. According to the instantaneous frequency, we found a correlation between the superorbital period and the modulation amplitude. Combining the spectral observation made by the Proportional Counter Array onboard RXTE and the superorbital phase derived in the HHT, we performed a superorbital phase-resolved spectral analysis of SMC X-1. An analysis of the spectral parameters versus the orbital phase for different superorbital states revealed that the diversity of nH has an orbital dependence. Furthermore, we obtained the variation in the eclipse profiles by folding the All Sky Monitor light curve with orbital period for different superorbital states. A dip feature, similar to the pre-eclipse dip of Her X-1, can be observed only in the superorbital ascending and descending states, while the width is anti-correlated with the X-ray flux.

  9. Climatic effects of irrigation over the Huang-Huai-Hai Plain in China simulated by the weather research and forecasting model

    NASA Astrophysics Data System (ADS)

    Yang, Ben; Zhang, Yaocun; Qian, Yun; Tang, Jian; Liu, Dongqing

    2016-03-01

    The climatic effects of irrigation over the Huang-Huai-Hai Plain (3HP) in China are investigated by using the weather research and forecasting model coupled with an operational-like irrigation scheme. Multiple numerical experiments with irrigation off/on during spring, summer, and both spring and summer are conducted. Results show that the warm bias in surface temperature and dry bias in soil moisture are reduced over the 3HP region during the growing seasons by considering the irrigation in the model. The air temperature during nongrowing seasons is also affected by irrigation because of the persistent effects of soil moisture on land-air energy exchanges and ground heat storage. Irrigation can induce significant cooling in the planetary boundary layer (PBL) during the growing seasons and lead to a relatively wet PBL with increased low-level clouds during spring but a relatively dry condition in summer. Further analyses indicate that irrigation leads to increased summer precipitation over the Yangtze River Basin and decreased summer precipitation in southern and northern China. These responses are associated with the changes in the large-scale circulation induced by irrigation. Irrigation tends to cool the atmosphere and forces a possible southward shift of the upper level jet that can further affect the precipitation distribution. Our model results suggest that in addition to local-scale processes, large-scale impacts should also be considered when studying the precipitation response to irrigation over East Asia.

  10. TIME-FREQUENCY ANALYSIS OF THE SUPERORBITAL MODULATION OF THE X-RAY BINARY SMC X-1 USING THE HILBERT-HUANG TRANSFORM

    SciTech Connect

    Hu, Chin-Ping; Chou, Yi; Yang, Ting-Chang; Su, Yi-Hao; Wu, Ming-Chya E-mail: yichou@astro.ncu.edu.tw

    2011-10-20

    The high-mass X-ray binary SMC X-1 exhibits a superorbital modulation with a dramatically varying period ranging between {approx}40 days and {approx}60 days. This research studies the time-frequency properties of the superorbital modulation of SMC X-1 based on the observations made by the All-Sky Monitor (ASM) onboard the Rossi X-ray Timing Explorer (RXTE). We analyzed the entire ASM database collected since 1996. The Hilbert-Huang transform (HHT), developed for non-stationary and nonlinear time-series analysis, was adopted to derive the instantaneous superorbital frequency. The resultant Hilbert spectrum is consistent with the dynamic power spectrum as it shows more detailed information in both the time and frequency domains. The RXTE observations show that the superorbital modulation period was mostly between {approx}50 days and {approx}65 days, whereas it changed to {approx}45 days around MJD 50,800 and MJD 54,000. Our analysis further indicates that the instantaneous frequency changed to a timescale of hundreds of days between {approx}MJD 51,500 and {approx}MJD 53,500. Based on the instantaneous phase defined by HHT, we folded the ASM light curve to derive a superorbital profile, from which an asymmetric feature and a low state with barely any X-ray emissions (lasting for {approx}0.3 cycles) were observed. We also calculated the correlation between the mean period and the amplitude of the superorbital modulation. The result is similar to the recently discovered relationship between the superorbital cycle length and the mean X-ray flux for Her X-1.

  11. Realgar- and cinnabar-containing an-gong-niu-huang wan (AGNH) is much less acutely toxic than sodium arsenite and mercuric chloride.

    PubMed

    Lu, Yuan-Fu; Yan, Jun-Wen; Wu, Qin; Shi, Jing-Zhen; Liu, Jie; Shi, Jing-Shan

    2011-01-15

    An-gong-niu-huang wan (AGNH) is a famous traditional Chinese medicine used for brain trauma, hemorrhage, and coma. AGNH contains 10% realgar (As₄S₄) and 10% cinnabar (HgS). Both As and Hg are well-known for their toxic effects, and the safety of AGNH is of concern. To address this question, the acute toxicity of AGNH, realgar and cinnabar were compared to sodium arsenite (NaAsO₂) and mercuric chloride (HgCl₂). Mice were administrated orally AGNH at 1, 3 and 6g/kg. AGNH at 3g/kg contains 2.8mmol As/kg as realgar and 1.18mmol Hg/kg as cinnabar. Realgar, cinnabar, arsenite (0.28 mmol/kg, 10% of realgar) and HgCl₂ (0.256 mmol/kg, 20% of cinnabar) were orally given to mice for comparison. Blood and tissues were collected 8h later for toxicity evaluation. Serum alanine aminotransferase was increased by arsenite and blood urea nitrogen was increased by HgCl₂. Total As accumulation after arsenite in liver (100-fold) and kidney (13-fold) was much higher than that after realgar. The accumulation of Hg after HgCl₂ in liver was 400-fold higher and kidney 30-fold higher than after cinnabar. Histopathology showed moderate liver and kidney injuries after arsenite and HgCl₂, but injuries were mild or absent after AGNH, realgar, and cinnabar. The expression of metallothionein-1, a biomarker of metal exposure, was increased 4-10-fold by arsenite and HgCl₂, but was unchanged by AGNH, realgar and cinnabar. Thus, AGNH, realgar and cinnabar are much less toxic acutely than arsenite and HgCl₂. The chemical forms of As and Hg are extremely important factors in determining their disposition and toxicity. PMID:21094152

  12. The Anticancer Properties and Apoptosis-inducing Mechanisms of Cinnamaldehyde and the Herbal Prescription Huang-Lian-Jie-Du-Tang ( Huáng Lián Jiě Dú Tang) in Human Hepatoma Cells.

    PubMed

    Lin, Liang-Tzung; Wu, Shu-Jing; Lin, Chun-Ching

    2013-10-01

    Hepatocellular carcinoma (HCC) has long been one of the most important causes of cancer mortality in the world. Many natural products and traditional herbal medicines have been used to treat HCC in Asian countries such as Japan, Korea, Taiwan, and China. The present review aims to describe the anticancer properties and apoptotic mechanisms of cinnamaldehyde, the bioactive ingredient isolated from cinnamon trees, and the herbal prescription Huang-Lian-Jie-Du-Tang ( Huáng Lián Jiě Dú Tang; HLJDT) against human hepatoma cells in vitro and in vivo. Implication of their treatment for the development of targeted therapy against HCC is discussed. PMID:24716182

  13. Liquid chromatography-hydride generation-atomic fluorescence spectrometry determination of arsenic species in dog plasma and its application to a pharmacokinetic study after oral administration of Realgar and Niu Huang Jie Du Pian.

    PubMed

    Zhang, Yunjing; Qiang, Shuping; Sun, Jing; Song, Min; Hang, Taijun

    2013-02-15

    A high performance liquid chromatography-hydride generation-atomic fluorescence spectrometry (HPLC-HG-AFS) method was developed for the simultaneous determination of four arsenic species (As(III), dimethylarsinic acid (DMA), monomethylarsonic acid (MMA) and arsenate As(V)) in dog plasma. Good separation of the four arsenic species was achieved within 15min on an anion-exchange column with isocratic elution using 15mmol/L KH(2)PO(4) (pH 5.9) as eluent at a flow rate of 1.0mL/min. The assay was linear over the range of 1.25-200, 1.56-200, 1.34-172, and 2.50-200ng/mL with the detection limits of 0.80, 1.00, 0.86 and 2.00ng/mL for As(III), DMA, MMA and As(V), respectively. The method was validated for selectivity, precision, accuracy and recovery and then applied to a comparative pharmacokinetic study of the arsenic species in beagle dogs after a single oral administration of Realgar (24.32mg/kg, equivalent to 11.31mgAs/kg) alone or Niu Huang Jie Du Pian (a patent traditional Chinese medicine (TCM), 380mg/kg, equivalent to 28.45mgAs/kg), respectively. DMA was found to be the predominant species in the dog plasma after dosing, with As(V) appeared as the quickly eliminating one. No traces of MMA and As(III) were detected at any sampling time points. The main pharmacokinetic parameters found for DMA p.o. administration of Realgar and Niu Huang Jie Du Pian were as follows: C(max) (14.7±4.2) and (57.0±32.0)ng/mL, T(max) (2.4±0.5) and (2.5±0.5)h, AUC(0-36) (151.1±12.9) and (635.9±418.2)ngh/mL, AUC(0-∞) (206.0±44.5) and (687.2±425.1)ngh/mL, t(1/2) (16.2±7.9) and (9.4±2.2)h, respectively. The influence of compounding in Niu Huang Jie Du Pian on the pharmacokinetics of arsenics was shown with increased transformation of DMA and its faster elimination rate. PMID:23376344

  14. [The soul outlook in the bamboo slips Fan yin (Anti-excessiveness) of Western Han Dynasty collected at Peking University and in Huang di nei jing (Inner Canon of Yellow Emperor)].

    PubMed

    DU, Feng

    2013-09-01

    The bamboo slips Fan yin (Anti-excessiveness) of the Western Han Dynasty, written in the form of conversation in 7-syllable prose-verse between hun (ethereal soul) and po (corporeal soul), with po as the host, and hun as the guest, reflecting the dualism of hun and po. In Huang di nei jing (Inner Canon of Yellow Emperor), appeared nearly at the same time, in which the hypothesis of all the five viscera embodies the spirit and its soul defined at the level of spirit-emotion, claiming that the physique and ethereal soul are born at the same time, and the spirit of Yang qi within the corporeal soul is the ethereal soul, which is different from the description in the Fan yin. PMID:24429031

  15. Coordinate Bethe ANSÄTZE for Non-Diagonal Boundaries

    NASA Astrophysics Data System (ADS)

    Ragoucy, Eric

    2013-11-01

    Bethe ansatz goes back to 1931, when H. Bethe invented it to solve some one-dimensional models, such as XXX spin chain, proposed by W. Heisenberg in 1928. Although it is a very powerful method to compute eigenvalues and eigenvectors of the corresponding Hamiltonian, it can be applied only for very specific boundary conditions: periodic boundary ones, and so-called open-diagonal boundary ones. After reviewing this method, we will present a generalization of it that applies also to open-triangular boundary conditions. This short note presents only the basic ideas of the technique, and does not attend to give a general overview of the subject. Interested readers should refer to the original papers and references therein.

  16. A Metabolomic Strategy to Screen the Prototype Components and Metabolites of Shuang-Huang-Lian Injection in Human Serum by Ultra Performance Liquid Chromatography Coupled with Quadrupole Time-of-Flight Mass Spectrometry

    PubMed Central

    Guo, Mingxing; Zhao, Baosheng; Liu, Haiyu; Zhang, Li; Peng, Long; Qin, Lingling; Zhang, Zhixin; Li, Jian; Cai, Chengke; Gao, Xiaoyan

    2014-01-01

    Shuang-huang-lian injection (SHLI) is a famous Chinese patent medicine, which has been wildly used in clinic to treat acute respiratory tract infection, pneumonia, influenza, and so forth. Despite the widespread clinical application, the prototype components and metabolites of SHLI have not been fully elucidated, especially in human body. To discover and screen the constituents or metabolites of Chinese medicine in biofluids tends to be more and more difficult due to the complexity of chemical compositions, metabolic reactions and matrix effects. In this work, a metabolomic strategy to comprehensively elucidate the prototype components and metabolites of SHLI in human serum conducted by UPLC-Q-TOF/MS was developed. Orthogonal partial least squared discriminant analysis (OPLS-DA) was applied to distinguish the exogenous, namely, drug-induced constituents, from endogenous in human serum. In the S-plot, 35 drug-induced constituents were found, including 23 prototype compounds and 12 metabolites which indicated that SHLI in human body mainly caused phase II metabolite reactions. It was concluded that the metabolomic strategy for identification of herbal constituents and metabolites in biological samples was successfully developed. This identification and structural elucidation of the chemical compounds provided essential data for further pharmacological and pharmacokinetics study of SHLI. PMID:24719777

  17. Metabolic fate analysis of Huang-Lian-Jie-Du Decoction in rat urine and feces by LC-IT-MS combining with LC-FT-ICR-MS: a feasible strategy for the metabolism study of Chinese medical formula.

    PubMed

    Zuo, Ran; Ren, Wei; Bian, Bao-Lin; Wang, Hong-Jie; Wang, Yao-Nan; Hu, Hao; Zhao, Hai-Yu; Si, Nan

    2016-01-01

    1. Huang-Lian-Jie-Du Decoction (HLJDD) is widely used for the treatment of hypertension, diabetes, inflammation and neural system diseases in clinic. In the present study, the comprehensive metabolic profile of HLJDD was demonstrated reliably and rapidly followed by the metabolic pathway analysis of six typical pure compounds (four alkaloids, one flavonoid and one iridoid) in HLJDD using LC-IT-MS combined with high resolution LC-FT-ICR-MS. 2. Totally, 85 compounds, including 32 prototype components and 53 biotransformed metabolites were detected and characterized in the urine and feces after oral administration of HLJDD and six pure compounds to rats, respectively. Among them, 17 prototypes were identified definitely with standard references. 3. Hydroxylation, demethylation and glucuronidation reactions of alkaloids, as well as glucuronidation and sulfonation reactions of iridoids and flavonoids, were observed as the major metabolic pathways of HLJDD. Flavonoids, iridoids and their metabolites were mainly excreted from urine. However, amount of alkaloids were detected in feces. 4. In general, the distinctive metabolic process of three kinds of representative components in HLJDD was clarified. The in vivo metabolic network of HLJDD was demonstrated. Meanwhile, the investigation of representative pure compounds in metabolic study provided a valuable strategy to elucidate the full-scale metabolic fate of HLJDD. This might be helpful to understand the in vivo mechanism of Traditional Chinese medicine (TCM). PMID:26084375

  18. UPLC-MS/MS determination of ephedrine, methylephedrine, amygdalin and glycyrrhizic acid in Beagle plasma and its application to a pharmacokinetic study after oral administration of Ma Huang Tang.

    PubMed

    Yan, Tianhua; Fu, Qiang; Wang, Jing; Ma, Shiping

    2015-02-01

    An ultra performance liquid chromatography-mass spectrometric (UPLC-MS) method was developed to investigate the pharmacokinetic properties of ephedrine, methylephedrine, amygdalin, and glycyrrhizic acid after oral gavage of Ma Huang Tang (MHT) in Beagles. Beagle plasma samples were pretreated using liquid-liquid extraction, and chromatographic separation was performed on a C18 column using a linear gradient of water-formic acid mixture (0.1%). The pharmacokinetic parameters of ephedrine, methylephedrine, amygdalin, and glycyrrhizic acid from MHT in Beagles were quantitatively determined by UPLC with tandem mass detector. The qualitative detection of the four compounds was accomplished by selected ion monitoring in negative/positive ion modes electrospray ionization-mass spectrometry (ESI-MS). Detection was based on multiple reaction monitoring with the precursor-to-product ion transitions m/z 166.096-116.983 (ephedrine), m/z 179.034-146.087 (methylephedrine), m/z 456.351-323.074 (amygdalin), and m/z 821.606-351.062 (glycyrrhizic acid). The selectivity, sensitivity, linearity, accuracy, precision, extraction recovery, ion suppression, and stability were within the acceptable ranges. The method described was successfully applied to reveal the pharmacokinetic properties of ephedrine, methylephedrine, amygdalin, and glycyrrhizic acid after oral gavage of MHT in Beagles. PMID:24824649

  19. Simultaneous multi-component quantitation of Chinese herbal injection Yin-zhi-huang in rat plasma by using a single-tube extraction procedure for mass spectrometry-based pharmacokinetic measurement.

    PubMed

    Zeng, Le; Wang, Meiling; Yuan, Yu; Guo, Bin; Zhou, Jing; Tan, Zhen; Ye, Meiling; Ding, Li; Chen, Bo

    2014-09-15

    Ying-zhi-huang injection (YZH-I) is an injectable multi-herbal prescription derived from the ancient Chinese remedy "Yin-chen-hao-tang", which is widely used in the clinic for the treatment of jaundice and chronic liver diseases. To date, little information is available on the pharmacokinetic properties of this poly-herbal formulation. Herein, we reported a simple, rapid and sensitive liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for quantitative multiple reaction monitoring (MRM) of eight major ingredients of YZH-I (including baicalin, baicalein, wogonoside, geniposide, geniposidic acid, chlorogenic acid, neochlorogenic acid, and caffeic acid) in rat plasma. A fast single-tube multi-impurity precipitation extraction ("SMIPE") procedure was introduced for straightforward plasma preparation, based on one-pot deproteinization precipitation with acidified methanol extraction and in-situ multifunction impurity removal by a solid sorbent mixture (anh. magnesium sulfate plus octadecylsilane). Particularly, the addition of ascorbic acid in methanol (10 mg/mL) was found to exhibit a pronounced protective effect and significantly increase extraction effectiveness of the herbal phenolic components. Some pretreatment variables (protein precipitating solvent, acidifying agent and sorbent) were optimized with acceptable matrix effect (-18 to 7.7%), extraction recovery (65-88%) and process efficiency (62-91%) for the SMIPE-based LC-MRM multi-analyte quantitation using matrix-matched calibration (5-1000 ng/mL) without using internal standard. Mean accuracies were obtained in the range of 83-114% at three different fortification levels, with intra- and inter-day variations within 13%. This validated method was successfully applied to the simultaneous measurement and pharmacokinetic investigation of the chemical constituents in rats following an intravenous administration of YZH-I. PMID:25129410

  20. Identification of the absorbed components and metabolites of Zhi-Zi-Da-Huang decoction in rat plasma by ultra-high performance liquid chromatography coupled with quadrupole-time-of-flight mass spectrometry.

    PubMed

    Zhu, Heyun; Bi, Kaishun; Han, Fei; Guan, Jiao; Zhang, Xiaoshu; Mao, Xinjuan; Zhao, Longshan; Li, Qing; Hou, Xiaohong; Yin, Ran

    2015-01-01

    Zhi-Zi-Da-Huang decoction (ZZDHD), consisting of Gardenia jasminoides Ellis, Rheum palmatum L., Citrus aurantium L. and Sojae Semen Praeparatum, is a widely used traditional Chinese medicine preparation for the treatment of acute or chronic hepatic diseases. In the present study, a sensitive and selective ultra-high performance liquid chromatography coupled with quadrupole-time-of-flight mass spectrometry (UHPLC-Q-TOF-MS) method was developed to separate and identify the absorbed components and metabolites in rat plasma after oral administration of ZZDHD. The plasma samples were pretreated by protein precipitation and separated on a Shim-pack XR-ODS C18 column (75 mm × 3.0 mm, 2.2 μm) using a gradient elution program. Mass spectrometric detection was performed on an Agilent 6520 Q-TOF mass spectrometer equipped with electrospray ionization (ESI) source in positive and negative ion modes. By comparing the retention time, high resolution mass data of blank plasma and dosed plasma, a total of 43 constituents, including 21 prototype compounds and 22 metabolites were identified or tentatively characterized. Results indicated that glucuronidation and sulfation were the main metabolic pathways of iridoid glycosides and anthraquinones, glucuronidation was the main metabolic pathways of flavanone-related compounds. It is concluded the developed UHPLC-Q-TOF-MS method with high sensitivity and resolution is suitable for identifying and characterizing the absorbed components and metabolites of ZZDHD, and the results will provide essential data for further studying the relationship between the chemical components and pharmacological activity of ZZDHD. PMID:25912849

  1. An untargeted metabolomics-driven approach based on LC-TOF/MS and LC-MS/MS for the screening of xenobiotics and metabolites of Zhi-Zi-Da-Huang decoction in rat plasma.

    PubMed

    Wu, Huan; Li, Xixi; Yan, Xuemei; An, Li; Luo, Kaiwen; Shao, Mingjing; Jiang, Yue; Xie, Rui; Feng, Fang

    2015-11-10

    Zhi-Zi-Da-Huang decoction (ZZDHD), a typical traditional Chinese medicine prescription, is widely used in clinical practice for the treatment of alcoholic liver disease. However, due to lack of holistic metabolic research, the active ingredients of ZZDHD have not been fully elucidated. It entails a huge obstacle for the quality evaluation, pharmacokinetic studies and clinical-safe medication administration of ZZDHD. In this work, an untargeted metabolomics-driven approach was proposed to rapidly screen and characterize xenobiotics and related metabolites in vivo conducted by LC-TOF/MS and LC-QqQ/MS. The tR-m/z pairs which were present in the ZZDHD-dosed group and absent in the control group could be clearly displayed by XCMS Online platform combined with supervised orthogonal partial least squares discriminant analysis. Among them, a total of 61 ZZDHD-related xenobiotics and metabolites including 34 prototype components and 27 metabolites were rapidly identified or tentatively characterized in rat plasma. The results indicated that iridoid glycosides and monoterpenoids from Gardenia jasminoides Ellis, flavonoid glycosides from Citrus aurantium L., as well as anthraquinones from Rheum palmatum L. were the main absorbed chemical components of ZZDHD. Hydrolysis, glucuronidation and sulfation were the main metabolic pathways of ZZDHD in vivo. The present study provided a solid basis for further revealing the relationship between the xenobiotic metabolome and pharmacological activity of ZZDHD. In addition, the application of untargeted metabolomics-driven approach offers a fresh insight for rapid screening and identifying xenobiotics and metabolites of ZZDHD and other multiherb prescription. PMID:26275719

  2. The history of Ephedra (ma-huang).

    PubMed

    Lee, M R

    2011-03-01

    Ephedra is a Chinese shrub which has been used in China for medicinal purposes for several thousand years. The pure alkaloid ephedrine was first isolated and characterised by Nagai in 1885. It was then forgotten until it was rediscovered by Chen and Schmidt in the early 1920s. Its actions on the adrenoceptors could be classified into separate alpha and beta effects--a defining moment in the history of autonomic pharmacology. Ephedrine became a highly popular and effective treatment for asthma, particularly because, unlike adrenaline (until then the standard therapy), it can be given by mouth. Ephedrine as a treatment for asthma reached its zenith in the late 1950s, since when there has been a gradual and inevitable decline in its therapeutic use. From mainstream medicine, ephedrine moved into the twilight zone of street drugs and nutritional supplements. Ephedra and ephedrine products are now banned in many countries, as they are a major source for the production of the addictive compound methamphetamine (crystal meth). PMID:21365072

  3. Atmospheric deposition as an important nitrogen load to a typical agro-ecosystem in the Huang-Huai-Hai Plain. 2. Seasonal and inter-annual variations and their implications (2008-2012)

    NASA Astrophysics Data System (ADS)

    Huang, Ping; Zhang, Jiabao; Ma, Donghao; Wen, Zhaofei; Wu, Shengjun; Garland, Gina; Pereira, Engil Isadora Pujol; Zhu, Anning; Xin, Xiuli; Zhang, Congzhi

    2016-03-01

    Atmospheric nitrogen (N) deposition, an important N source to agro-ecosystems, has increased intensively in China during recent decades. However, knowledge on temporal variations of total N deposition and their influencing factors is limited due to lack of systematic monitoring data. In this study, total N deposition, including dry and wet components, was monitored using the water surrogate surface method for a typical agro-ecosystem with a winter wheat (Triticum aestivum L.) and summer maize (Zea mays L.) rotation system in the Huang-Huai-Hai Plain from May 2008 to April 2012. The results indicated that annual total N deposition ranged from 23.8 kg N ha-1 (2009-2010) to 40.3 kg N ha-1 (2008-2009) and averaged 31.8 kg N ha-1. Great inter-annual variations were observed during the sampling period, due to differences in annual rainfall and gaseous N losses from farmlands. Monthly total N deposition varied greatly, from less than 0.6 kg N ha-1 (January, 2010) to over 8.0 kg N ha-1 (August, 2008), with a mean value of 2.6 kg N ha-1. In contrast to wet deposition, dry portions generally contributed more to the total, except in the precipitation-intensive months, accounting for 65% in average. NH4+ -N was the dominant species in N deposition and its contribution to total deposition varied from 6% (December, 2009) to 79% (July, 2008), averaging 53%. The role of organic N (O-N) in both dry and wet deposition was equal to or even greater than that of NO3- -N. Influencing factors such as precipitation and its seasonal distribution, reactive N sources, vegetation status, field management practices, and weather conditions were responsible for the temporal variations of atmospheric N deposition and its components. These results are helpful for reducing the knowledge gaps in the temporal variations of atmospheric N deposition and their influencing factors in different ecosystems, to improve the understandings on N budget in the typical agro-ecosystem, and to provide references and recommendations for field nutrient management in this region.

  4. Chemical profiling approach to evaluate the influence of traditional and simplified decoction methods on the holistic quality of Da-Huang-Xiao-Shi decoction using high-performance liquid chromatography coupled with diode-array detection and time-of-flight mass spectrometry.

    PubMed

    Yan, Xuemei; Zhang, Qianying; Feng, Fang

    2016-04-01

    Da-Huang-Xiao-Shi decoction, consisting of Rheum officinale Baill, Mirabilitum, Phellodendron amurense Rupr. and Gardenia jasminoides Ellis, is a traditional Chinese medicine used for the treatment of jaundice. As described in "Jin Kui Yao Lue", a traditional multistep decoction of Da-Huang-Xiao-Shi decoction was required while simplified one-step decoction was used in recent repsorts. To investigate the chemical difference between the decoctions obtained by the traditional and simplified preparations, a sensitive and reliable approach of high-performance liquid chromatography coupled with diode-array detection and electrospray ionization time-of-flight mass spectrometry was established. As a result, a total of 105 compounds were detected and identified. Analysis of the chromatogram profiles of the two decoctions showed that many compounds in the decoction of simplified preparation had changed obviously compared with those in traditional preparation. The changes of constituents would be bound to cause the differences in the therapeutic effects of the two decoctions. The present study demonstrated that certain preparation methods significantly affect the holistic quality of traditional Chinese medicines and the use of a suitable preparation method is crucial for these medicines to produce special clinical curative effect. This research results elucidated the scientific basis of traditional preparation methods in Chinese medicines. PMID:26914461

  5. Application of Hilbert-Huang transformation to fault diagnosis of rotary machinery

    NASA Astrophysics Data System (ADS)

    Chen, Feng; Zhou, Xiang; Wu, Qinghua; He, Tao; He, Haixia

    2008-10-01

    The vibration signal of a rotor bearing system is usually nonlinear and non-stationary. Fourier transform is hard to analyze these signals. A new method based upon empirical mode decomposition (EMD) and Hilbert spectrum is proposed for fault diagnosis of roller bearings. We get vibration signals from 6205-type ball bearings with inner-race faults and with outer-race faults, then analyzing its local Hilbert spectrum and local Hilbert marginal spectrum. Comparing the results with theory value, we can diagnose the fault of rotary machinery fault. In this study, we find that local Hilbert spectrum and local Hilbert marginal spectrum are very useful. Hilbert Transformation is introduced to confirm the HHT method is fit to process nonlinear and non-stationary signals.

  6. Optical sectioning microscopy using two-frame structured illumination and Hilbert-Huang data processing

    NASA Astrophysics Data System (ADS)

    Trusiak, M.; Patorski, K.; Tkaczyk, T.

    2014-12-01

    We propose a fast, simple and experimentally robust method for reconstructing background-rejected optically-sectioned microscopic images using two-shot structured illumination approach. Innovative data demodulation technique requires two grid-illumination images mutually phase shifted by π (half a grid period) but precise phase displacement value is not critical. Upon subtraction of the two frames the input pattern with increased grid modulation is computed. The proposed demodulation procedure comprises: (1) two-dimensional data processing based on the enhanced, fast empirical mode decomposition (EFEMD) method for the object spatial frequency selection (noise reduction and bias term removal), and (2) calculating high contrast optically-sectioned image using the two-dimensional spiral Hilbert transform (HS). The proposed algorithm effectiveness is compared with the results obtained for the same input data using conventional structured-illumination (SIM) and HiLo microscopy methods. The input data were collected for studying highly scattering tissue samples in reflectance mode. In comparison with the conventional three-frame SIM technique we need one frame less and no stringent requirement on the exact phase-shift between recorded frames is imposed. The HiLo algorithm outcome is strongly dependent on the set of parameters chosen manually by the operator (cut-off frequencies for low-pass and high-pass filtering and η parameter value for optically-sectioned image reconstruction) whereas the proposed method is parameter-free. Moreover very short processing time required to efficiently demodulate the input pattern predestines proposed method for real-time in-vivo studies. Current implementation completes full processing in 0.25s using medium class PC (Inter i7 2,1 GHz processor and 8 GB RAM). Simple modification employed to extract only first two BIMFs with fixed filter window size results in reducing the computing time to 0.11s (8 frames/s).

  7. Determination of phase derivatives from a single fringe pattern using Teager Hilbert Huang transform

    NASA Astrophysics Data System (ADS)

    Deepan, B.; Quan, C.; Tay, C. J.

    2016-01-01

    In this paper, a novel sequential algorithm for the estimation of phase derivatives from a single fringe pattern using electronic speckle pattern interferometry (ESPI) is proposed. The algorithm is based on empirical mode decomposition (EMD), vortex operator (VO) and Teager-Kaiser energy operator (TKEO). The empirical mode decomposition normalizes the fringe pattern; while vortex operator provides a 2D complex image and the phase derivatives are obtained using a novel image demodulation method called discrete higher order image demodulation algorithm (DHODA). Unlike phase shifting and Fourier transform methods, the proposed method does not require complex experimental setup or more than one fringe pattern for each deformation state. The proposed method is also able to provide phase derivatives in both the x and ydirections from a single fringe pattern, which is difficult to achieve using shearography. Since the algorithm provides unwrapped phase derivatives directly, it does not require separate phase unwrapping process. Hence it is suitable for dynamic strain and curvature measurement. The proposed algorithm is validated by both simulation and experiment. The results are found to be accurate and the method requires less computation time than existing phase demodulation techniques.

  8. A Novel Ship-rocking Forecasting Method based on Hilbert- Huang Transform

    NASA Astrophysics Data System (ADS)

    De-yong, Kang; Yu-jian, Li; Xu-liang, Wang; Zhi, Chen

    2016-02-01

    The ship-rocking is a crucial factor which affects the accuracy of the ocean-based aerospace vehicle measurement. Here we have analysed groups of ship-rocking time series in horizontal and vertical directions utilizing a Hilbert based method from statistical physics. Based on these results we could predict certain amount of future values of the ship-rocking time series based on the current and the previous values. Our predictions are as accurate as the conventional methods from stochastic processes and provide a much wider prediction time range.

  9. Analyzing nonstationary financial time series via hilbert-huang transform (HHT)

    NASA Technical Reports Server (NTRS)

    Huang, Norden E. (Inventor)

    2008-01-01

    An apparatus, computer program product and method of analyzing non-stationary time varying phenomena. A representation of a non-stationary time varying phenomenon is recursively sifted using Empirical Mode Decomposition (EMD) to extract intrinsic mode functions (IMFs). The representation is filtered to extract intrinsic trends by combining a number of IMFs. The intrinsic trend is inherent in the data and identifies an IMF indicating the variability of the phenomena. The trend also may be used to detrend the data.

  10. VizieR Online Data Catalog: A catalogue of Paschen-line profiles (Huang+, 2012)

    NASA Astrophysics Data System (ADS)

    Huang, W.; Wallerstein, G.; Stone, M.

    2012-09-01

    This catalogue contains spectroscopic data of 90 stars. A wide variety of stars were observed at H-α and at P-δ. A few stars were observed at P-γ. Most of the data were obtained at the Dominion Astrophysical Observatory (DAO). The remainder of the data were obtained at the Apache Point Observatory. (4 data files).

  11. Analytical design of densely dispersion-managed optical fiber transmission systems with Gaussian and raised cosine return-to-zero Ansätze

    NASA Astrophysics Data System (ADS)

    Nakkeeran, K.; Kwan, Y. H. C.; Wai, P. K. A.; Labruyère, A.; Tchofo Dinda, P.; Moubissi, A. B.

    2004-11-01

    We propose an easy and efficient way to analytically design densely dispersion-managed fiber systems for ultrafast optical communications. This analytical design is based on the exact solution of the variational equations derived from the nonlinear Schrödinger equation by use of either a Gaussian or a raised-cosine (RC) Ansatz. For the input pulses of dispersion-managed optical fiber transmission systems we consider a RC profile and show that RC return-to-zero pulses are as effective as Gaussian pulses in high-speed (160-Gbits/s) long-distance transmissions.

  12. Huang Qi Elixir for proteinuria in patients with diabetic nephropathy: a study protocol for a randomized controlled pilot trial

    PubMed Central

    2013-01-01

    Background Diabetic nephropathy (DN) is the major complication of diabetes; proteinuria is the hall mark of DN. Currently, the treatment for proteinuria is mainly limited to angiotensin converting enzyme (ACE) inhibitors or angiotensin II receptor blockers (ARBs). According to Traditional Chinese Medicine (TCM) theory, Chinese medicinals securing essence and tonifying the kidney may be appropriate for proteinuria. The most promising Chinese medicinals and formulae are introduced in the present study to form a potent formula for DN proteinuria. To make oral administration convenient, the formula will be processed in the form of granules. Methods/design A randomized, multi-center pilot trial will be conducted. Forty eight participants with DN will be randomly assigned to one of four treatment groups: 1. A granule group, at 10 grams, three times daily (G10 group, n?=?12); 2. A granule group, at 20 grams, three times daily (G20 group, n?=?12); 3. A decoction group (D group, n?=?12); and 4. An irbesartan group (Aprovel group, n?=?12). The following outcome measures will be used: the percentage change of the albumin-to-creatinine ratio; and the changes in serum creatinine, glomerular filtration rate, fasting plasma glucose and hemoglobulin from baseline to the end of the trial. Discussion It is notable that most published clinical trials which assessed the efficacy of TCM on DN were of poor methodology and, therefore, their results have been invalidated. It is necessary to carry out well-designed clinical trials to provide sound evidence. The present trial is a study with potentially great value, for it will provide the parameters for future randomized, placebo-controlled, clinical trials with large sample sizes. Trial registration The trial is registered on the Chinese Clinical Trial Registry: ChiCTR-TRC-12002718 (http://www.chictr.org/cn/proj/show.aspx?proj=3820). PMID:23866835

  13. [Morphological and histological studies of Chinese Ephedra, ma huang. II. Species produced in southwestern China and other species].

    PubMed

    Zhang, J S; Li, S H; Lou, Z C

    1990-01-01

    In this paper, the morphological and histological characters of crude drugs derived from Ephedra likiangensis Florin, E. likiangensis f. mairei (Florin) C. Y. Cheng, E. saxatilis Royle ex Florin, E. gerardiana Wall, E. gerardiana var. congesta C. Y. Cheng, E. minuta Florin, E. minuta var. dioeca C. Y. Cheng, E. lepidosperma C. Y. Cheng, E. lomatolepis Schrenk and E. intermedia var. tibetica Stapf are described, compared and illustrated with line drawings. It was found that all the Ephedra spp. growing in southwester nChina possess the following features in common, viz. (1) numerous distinct longitudinal ridges are present on the stem; (2) xylem fibres and tracheids possess steep, tertiary spiral thickenings; (3) stone cells (sclereids) are absent from the nodes. According to the above characters, the drugs produced in southwestern China can be differentiated from those produced in northern China. The results also show that the histological characters of E. intermedia var tibetica Stapf produced in southeast ern Xizang (Tibet) are different from those produced in north western Xizang. The former possesses the xylem fibres and tracheids with steep, tertiary spiral thickenings, while the latter possesses sclereids at stem-nodes. It may be related to their habitat factors and interspecies hybridization. A key for identification of all the crude drugs derived from Chinese Ephedra spp. studied in this series of paper, including thirteen species, three varieties and one form is presented. PMID:2363358

  14. Qin, Han, and Huang: Text Reproduction and Literacy in Rural China, A Case for Euclid and Homer.

    ERIC Educational Resources Information Center

    Bain, Bruce; Yu, Agnes

    1991-01-01

    Debates the merits of the claim that "symbolic technologies push cognitive growth earlier and longer." The results of an assessment are presented that involved three adult male peasants (two literate, one nonliterate) living in rural China and their ability to recall the text of "The Lonesome Opossum." (25 references) (GLR)

  15. First International Conference between West and East-Leonardo and Lao-Tze. Western Science Meets Eastern Wisdom. Experiences of Scientists and Intellectuals for the Creation of a New Paradigm of Modern Science.

    PubMed

    Daniele, Flavio

    2008-03-01

    The Conference was organized and supported by: Nei Dan School (European School of Internal Martial Arts), NIB (Laboratory of Molecular Biology and Stem Cell Bioengineering, National Institute of Biostructures and Biosystems, Institute of Cardiology, S.Orsola-Malpighi Hospital, Bologna), WACIMA (Worldwide Association Chinese Internal Martial Arts), Arti D'Oriente(Magazine of Eastern culture and traditions), Nuovo Orizzonte (Taiji Quan School in Florence), Samurai (Journal on Martial Arts), and Pinus (First National Institute for the Unification of Medical Strategies). Nei Dan School (www.taichineidan.com, neidan@libero.it) was in charge of the organization. Future meetings of the Centro studi 'Tao and Science' will take place in spring 2007 in Firenze and in October 2007 in Bologna. For information: E-mail: neidan@libero.it; web site: www.taichineidan.com, www.taoandscience.com. PMID:18317548

  16. First International Conference between West and East—Leonardo and Lao-Tze. Western Science Meets Eastern Wisdom. Experiences of Scientists and Intellectuals for the Creation of a New Paradigm of Modern Science

    PubMed Central

    2008-01-01

    The Conference was organized and supported by: Nei Dan School (European School of Internal Martial Arts), NIB (Laboratory of Molecular Biology and Stem Cell Bioengineering, National Institute of Biostructures and Biosystems, Institute of Cardiology, S.Orsola-Malpighi Hospital, Bologna), WACIMA (Worldwide Association Chinese Internal Martial Arts), Arti D’Oriente (Magazine of Eastern culture and traditions), Nuovo Orizzonte (Taiji Quan School in Florence), Samurai (Journal on Martial Arts), and Pinus (First National Institute for the Unification of Medical Strategies). Nei Dan School (www.taichineidan.com, neidan@libero.it) was in charge of the organization. Future meetings of the Centro studi ‘Tao and Science’ will take place in spring 2007 in Firenze and in October 2007 in Bologna. For information: E-mail: neidan@libero.it; web site: www.taichineidan.com, www.taoandscience.com PMID:18317548

  17. Different structural preference of Ag(i) and Au(i) in neutral and cationic luminescent heteropolynuclear platinum(ii) complexes: Z (U)-shaped Pt2M2 type vs. trinuclear PtM2 type.

    PubMed

    Nishihara, Kazuki; Ueda, Misa; Higashitani, Ami; Nakao, Yoshihide; Arikawa, Yasuhiro; Horiuchi, Shinnosuke; Sakuda, Eri; Umakoshi, Keisuke

    2016-03-15

    The reactions of monocationic Pt(ii) complexes bearing N^C chelate ligands and Me2pzH, [Pt(N^C)(Me2pzH)2]PF6 (N^C = 2-phenylpyridinate (ppy(-)), 2-(2,4-difluorophenyl)pyridinate (dfppy(-)), benzo[h]quinolinate (bzq(-)); Me2pzH = 3,5-dimethylpyrazole), with Ag(i) ions gave Z (or U)-shaped neutral tetranuclear Pt2Ag2 complexes [Pt2Ag2(N^C)2(Me2pz)4], while those with Au(i) ions gave neutral trinuclear PtAu2 complexes [PtAu2(N^C)(Me2pz)3]. On the contrary, the reactions of the dicationic Pt(ii) complex bearing a N^N chelate ligand and Me2pzH, [Pt(bpy)(Me2pzH)2](PF6)2 (bpy = 2,2'-bipyridine), with Ag(i) and Au(i) ions both gave Z (or U)-shaped dicationic tetranuclear Pt2M2 complexes, [Pt2M2(bpy)2(Me2pz)4](PF6)2 (M = Ag, Au). The structures of heteropolynuclear Pt(ii) complexes were dominated by the nature of incorporated group 11 metal ions and the charge of complexes. PMID:26924605

  18. Carbon Sequestration Efficiency of Organic Amendments in a Long-Term Experiment on a Vertisol in Huang-Huai-Hai Plain, China

    PubMed Central

    Hua, Keke; Wang, Daozhong; Guo, Xisheng; Guo, Zibin

    2014-01-01

    Soil organic carbon (SOC) sequestration is important for improving soil fertility of cropland and for the mitigation of greenhouse gas emissions to the atmosphere. The efficiency of SOC sequestration depends on the quantity and quality of the organic matter, soil type, and climate. Little is known about the SOC sequestration efficiency of organic amendments in Vertisols. Thus, we conducted the research based on 29 years (1982–2011) of long-term fertilization experiment with a no fertilizer control and five fertilization regimes: CK (control, no fertilizer), NPK (mineral NPK fertilizers alone), NPK+1/2W (mineral NPK fertilizers combined with half the amount of wheat straw), NPK+W (mineral NPK fertilizers combined with full the amount of wheat straw), NPK+PM (mineral NPK fertilizers combined with pig manure) and NPK+CM (mineral NPK fertilizers combined cattle manure). Total mean annual C inputs were 0.45, 1.55, 2.66, 3.71, 4.68 and 6.56 ton/ha/yr for CK, NPK, NPKW1/2, NPKW, NPKPM and NPKCM, respectively. Mean SOC sequestration rate was 0.20 ton/ha/yr in the NPK treatment, and 0.39, 0.50, 0.51 and 0.97 ton/ha/yr in the NPKW1/2, NPKW, NPKPM, and NPKCM treatments, respectively. A linear relationship was observed between annual C input and SOC sequestration rate (SOCsequestration rate  = 0.16 Cinput –0.10, R = 0.95, P<0.01), suggesting a C sequestration efficiency of 16%. The Vertisol required an annual C input of 0.63 ton/ha/yr to maintain the initial SOC level. Moreover, the C sequestration efficiencies of wheat straw, pig manure and cattle manure were 17%, 11% and 17%, respectively. The results indicate that the Vertisol has a large potential to sequester SOC with a high efficiency, and applying cattle manure or wheat straw is a recommendable SOC sequestration practice in Vertisols. PMID:25265095

  19. Carbon sequestration efficiency of organic amendments in a long-term experiment on a vertisol in Huang-Huai-Hai Plain, China.

    PubMed

    Hua, Keke; Wang, Daozhong; Guo, Xisheng; Guo, Zibin

    2014-01-01

    Soil organic carbon (SOC) sequestration is important for improving soil fertility of cropland and for the mitigation of greenhouse gas emissions to the atmosphere. The efficiency of SOC sequestration depends on the quantity and quality of the organic matter, soil type, and climate. Little is known about the SOC sequestration efficiency of organic amendments in Vertisols. Thus, we conducted the research based on 29 years (1982-2011) of long-term fertilization experiment with a no fertilizer control and five fertilization regimes: CK (control, no fertilizer), NPK (mineral NPK fertilizers alone), NPK+1/2W (mineral NPK fertilizers combined with half the amount of wheat straw), NPK+W (mineral NPK fertilizers combined with full the amount of wheat straw), NPK+PM (mineral NPK fertilizers combined with pig manure) and NPK+CM (mineral NPK fertilizers combined cattle manure). Total mean annual C inputs were 0.45, 1.55, 2.66, 3.71, 4.68 and 6.56 ton/ha/yr for CK, NPK, NPKW1/2, NPKW, NPKPM and NPKCM, respectively. Mean SOC sequestration rate was 0.20 ton/ha/yr in the NPK treatment, and 0.39, 0.50, 0.51 and 0.97 ton/ha/yr in the NPKW1/2, NPKW, NPKPM, and NPKCM treatments, respectively. A linear relationship was observed between annual C input and SOC sequestration rate (SOCsequestration rate  = 0.16 Cinput -0.10, R = 0.95, P<0.01), suggesting a C sequestration efficiency of 16%. The Vertisol required an annual C input of 0.63 ton/ha/yr to maintain the initial SOC level. Moreover, the C sequestration efficiencies of wheat straw, pig manure and cattle manure were 17%, 11% and 17%, respectively. The results indicate that the Vertisol has a large potential to sequester SOC with a high efficiency, and applying cattle manure or wheat straw is a recommendable SOC sequestration practice in Vertisols. PMID:25265095

  20. Effect of various absorption enhancers based on tight junctions on the intestinal absorption of forsythoside A in Shuang-Huang-Lian, application to its antivirus activity

    PubMed Central

    Zhou, Wei; Zhu, Xuan Xuan; Yin, Ai Ling; Cai, Bao Chang; Wang, Hai Dan; Di, Liuqing; Shan, Jin Jun

    2014-01-01

    Background: Forsythoside A (FTA), one of the main active ingredients in Shuang–Huang–Lian (SHL), possesses strong antibacterial, antioxidant and antiviral effects, and its pharmacological effects was higher than that of other ingredients, but the absolute bioavailability orally was approximately 0.72%, which was significantly low, influencing clinical efficacies of its oral preparations seriously. Materials and Methods: In vitro Caco-2 cell and in vivo pharmacokinetics study were simultaneously performed to investigate the effects of absorption enhancers based on tight junctions: sodium caprate and water-soluble chitosan on the intestinal absorption of FTA, and the eventual mucosal epithelial damage resulted from absorption enhancers was evaluated by MTT test and morphology observation, respectively. The pharmacological effects such as antivirus activity improvement by absorption enhancers were verified by MDCK damage inhibition rate after influenza virus propagation. Results: The observations from in vitro Caco-2 cell showed that the absorption of FTA in SHL could be improved by absorption enhancers. Meanwhile, the absorption enhancing effect of water-soluble chitosan may be almost saturable up to 0.0032% (w/v), and sodium caprate at concentrations up to 0.64 mg/mL was safe, but water-soluble chitosan at different concentrations was all safe for these cells. In pharmacokinetics study, water-soluble chitosan at dosage of 50 mg/kg improved the bioavailability of FTA in SHL to the greatest extent, and was safe for gastrointestine from morphological observation. Besides, treatment with SHL with water-soluble chitosan at dosage of 50 mg/kg prevented MDCK damage after influenza virus propagation better significantly than that of control. Conclusion: Water-soluble chitosan at dosage of 50 mg/kg might be safe and effective absorption enhancer for improving the bioavailability of FTA and the antivirus activity in vitro in SHL. PMID:24695554

  1. Emission Flux of Soil Carbon Dioxide in Hydrothermal Area of the Tatun Volcano Group, Northern Taiwan

    NASA Astrophysics Data System (ADS)

    Wen, H.; Yang, T. F.; Lan, T. F.; Lee, H.

    2009-12-01

    Tatun Volcano Group (TVG) is located at north of Taiwan and considered as a potential active volcano. Hydrothermal activity occurs actively along the Chinshan Fault in this area. Based on the numbers of active fumarole/venting in the area, we can classify TVG into three major groups: (I) active hydrothermal area with major fumaroles (e.g., Da-you-keng, DYK), (II) active hydrothermal area without major fumaroles (e.g., Geng-tze-ping, GTP and Liu-huang-ku, LHK), and (III) non-active hydrothermal area (e.g., Tatun Natural Park, TNP). In this study we measure the soil CO2 flux in the representative areas of TVG by closed-chamber method. Soil CO2 flux can be obtained ca. 537 g m-2 day-1 at GTP, ca. 122 g m-2 day-1 at DYK, and ca. 25 g m-2 day-1 at TNP, respectively. We can compare these values with previous measured data of soil CO2 flux at LHK, 659 g m-2 day-1, which is close to the value of GTP but much higher than that of DYK. The results show that the emission flux of soil CO2 at group-I area (DYK) is much lower than the value of group-II area (GTP and LHK). It could be explained that most CO2 gas can release to the surface through the highly permeable conduit/pathway (fumaroles) at group-I area and hence, less emission flux of soil CO2 can be observed. Furthermore, the total amount of 111 t day-1 of soil CO2 in the hydrothermal area of TVG can be estimated. It is close to the values from other active hydrothermal areas in the world.

  2. [National Institute of Hygiene during the World War 1939-1944].

    PubMed

    Gromulska, Marta

    2008-01-01

    The article presents history of the National Institute of Hygiene (PZH) in the period from September 1939 until the fall of Warsaw Uprising (1944). German occupation left unaltered activities, structure and Polish personnel of the Institute, enforcing commissoner board by professor Ernst Nauck, and subsequently--professor Robert Kudicke from Frankfurt. German production of vaccine against typhus exanthematous for German army was managed by German physician--Herman Wohlrab. National Institute of Hygiene was to be a place modelled on Institute for Tropical Diseases in Hamburg. Polish personnel was subject to military regime, however Feliks Przesmycki, PhD started underground production of vaccine against typhus exanthematous for Polish citizens, which was distributed to prisons (Pawiak Prison) and ghetto. Hospital personnel in Warsaw was also vaccinated. Underground studies programme, including editing handbooks, was set up for the students of closed Microbiology Faculty of Warsaw University, and other wartime conspiracy actions were taken. Personnel of National Institute of Hygiene (PZH) protected research equipment and supplies from war plundering, and supported Polish civilians by e.g. reporting about harmfulness of low-quality and polluted food for the Polish, which Germans supplied market with. During Warsaw Uprising Personnel helped the injured and protected the premises of National Institute of Hygiene (PZH) from burning down; mobile army surgical hospital and pharmacy for the participans of Warsaw Uprising functioned within PZH. PMID:19209734

  3. [Branches of the National Institute of Hygiene].

    PubMed

    Gromulska, Marta

    2008-01-01

    National Epidemiological Institute (National Institute of Hygiene, from 7th September 1923) was established in 1918 in Warsaw and acted at national level. Its actions in the field of diseases combat were supported by bacteriological stations and vaccine production in voivodeship cities, which were taken charge of by the state, and names "National Epidemiological Institutes". According to the ministers resolution from 6th July 1921,Epidemiological Institutes were merged to National Central Epidemiological Institutes (PZH), the epidemiological institutes outside Warsaw were named branches, which were to be located in every voivodeship city, according to the initial organizational resolutions. There were country branches of NCEI in: Cracow, Lwów, Lódź, Toruń, Lublin, and Wilno in the period 1919-1923. New branches in Poznań (1925), Gdynia(1934), Katowice (Voivodeship Institute of Hygiene (1936), Luck (1937), Stanisławów (1937), Kielce(1938), and Brześć/Bug (Municipal Station acting as branch of National Central Epidemiological Institute. Branches were subordinated to NCEI-PZH) in Warsaw where action plans and unified research and diagnostic method were established and annual meeting of the country branches managers took place. All branches cooperated with hospitals, national health services, district general practitioners and administration structure in control of infectious diseases. In 1938, the post of branch inspector was established, the first of whom was Feliks Przesmycki PhD. Branches cooperated also with University of Cracow, University of Lwów and University of Wilno. In 1935, National Institutes of Food Research was incorporated in PZH, Water Department was established, and these areas of activity began to develop in the branches accordingly. In 1938 there were 13 branches of PZH, and each had three divisions: bacteriological, food research and water research. Three branches in Cracow, Kielce and Lublin worked during World War II under German supervision. PZH activities were restored in 1945 with new branches in Gdańsk, Wrocław(1945), Olsztyn and Szczecin (1947), and Rzeszów (1950). In 1951 there were already 14 country branches of National Institute of Hygiene (PZH) in voivodeship cities and 4 minor branches in Zakopane, Radom, Czestochowa and Walbrzych. In 31th December branches of the National Institute of Hygiene (PZH) were restructured and named Sanitary-Epidemiological Stations. PMID:19209733

  4. Transition from hydrogen atom to hydride abstraction by Mn4O4(O2PPh2)6 versus [Mn4O4(O2PPh2)6]+: O-H bond dissociation energies and the formation of Mn4O3(OH)(O2PPh2)6.

    PubMed

    Carrell, Thomas G; Bourles, Emilie; Lin, Matthew; Dismukes, G Charles

    2003-05-01

    Synthesis, characterization, and reactions of the novel manganese-oxo cubane complex [Mn(4)O(4)(O(2)PPh(2))(6)](ClO(4)), 1+ (ClO(4)(-)), are described. Cation 1+ is composed of the [Mn(4)O(4)](7+) core surrounded by six bidentate phosphinate ligands. The proton-coupled electron transfer (pcet) reactions of phenothiazine (pzH), the cation radical (pzH(.+)(ClO(4)(-)), and the neutral pz* radical with 1+ are reported and compared to Mn(4)O(4)(O(2)PPh(2))(6) (1). Compound 1+ (ClO(4)(-)) reacts with excess pzH via four sequential reduction steps that transfer a total of five electrons and four protons to 1+. This reaction forms the doubly dehydrated manganese cluster Mn(4)O(2)(O(2)PPh(2))(6) (2) and two water molecules derived from the corner oxygen atoms. The first pcet step forms the novel complex Mn(4)O(3)(OH)(O(2)PPh(2))(6) (1H) and 1 equiv of the pz+ cation by net hydride transfer from pzH. Spectroscopic characterization of isolated 1H is reported. Reduction of 1 by pzH or a series of para-substituted phenols also produces 1H via net H atom transfer. A lower limit to the homolytic bond dissociation energy (BDE) (1H --> 1 + H) was estimated to be >94 kcal/mol using solution phase BDEs for pzH and para-substituted phenols. The heterolytic BDE was estimated for the hydride transfer reaction 1H --> 1+ + H(-) (BDE approximately 127 kcal/mol). These comparisons reveal the O-H bond in 1H to be among the strongest of any Mn-hydroxo complex measured thus far. In three successive H atom transfer steps, 1H abstracts three hydrogen atoms from three pzH molecules to form complex 2. Complex 2 is shown to be identical to the "pinned butterfly" cluster produced by the reaction of 1 with pzH (Ruettinger, W. F.; Dismukes, G. C. Inorg. Chem. 2000, 39, 1021-1027). The Mn oxidation states in 2 are formally Mn(4)(2II,2III), and no further reduction occurs in excess pzH. By contrast, outer-sphere electron-only reductants such as cobaltacene reduce both 1+ and 1 to the all Mn(II) oxidation level and cause cluster fragmentation. The reaction of pzH(.+) with 1+ produces 1H and the pz+ cation by net hydrogen atom transfer, and terminates at 1 equiv of pzH(.+) with no further reaction at excess. By contrast, pz* does not react with 1+ at all, indicating that reduction of 1+ by electron transfer to form pz+ does not occur without a proton (pcet to 1+ is thermodynamically required). Experimental free energy changes are shown to account for these pcet reactions and the absence of electron transfer for any of the phenothiazine series. Hydrogen atom abstraction from substrates by 1 versus hydride abstraction by 1(+ )()illustrates the transition to two-electron one-proton pcet chemistry in the [Mn(4)O(4)](7+) core that is understood on the basis of free energy consideration. This transition provides a concrete example of the predicted lowest-energy pathway for the oxidation of two water molecules to H(2)O(2) as an intermediate within the photosynthetic water-oxidizing enzyme (vs sequential one-electron/proton steps). The implications for the mechanism of photosynthetic water splitting are discussed. PMID:12716176

  5. Structure and photoluminescence of silver(i) trinuclear halopyrazolato complexes.

    PubMed

    Morishima, Yui; Young, David James; Fujisawa, Kiyoshi

    2014-11-14

    Five halogen substituted pyrazolates, 4-chloro-3,5-diisopropylpyrazole (4-Cl-3,5-iPr2pzH), 4-bromo-3,5-diisopropylpyrazole (4-Br-3,5-iPr2pzH), 4-iodo-3,5-diisopropylpyrazole (4-I-3,5-iPr2pzH), 4-chloro-3,5-diphenylpyrazole (4-Cl-3,5-Ph2pzH), and 4-bromo-3,5-diphenylpyrazole (4-Br-3,5-Ph2pzH), were conveniently prepared by halogenation of the appropriate pyrazoles with N-halosuccinimides (NXS) (X = Cl, Br, and I) followed by complexation of the pyrazolate anions with silver(i) nitrate. Single crystal X-ray analysis revealed either dimeric trinuclear {[Ag(μ-4-X-3,5-R2pz)]3}2 (R = iPr, X = Cl, Br, and I) or trinuclear [Ag(μ-4-X 3,5-R2pz)]3 (R = iPr, X = I; R = Ph, X = Cl, R = Ph, X = Br) structures, the latter held together with argentophilic interactions (AgAg interactions) that could also be observed in the Raman spectra. The electronegativity of the halogen substituent could be correlated with the strength of the AgAg interaction and the wavelength of solid-state photoluminescence. All complexes were emissive on UV irradiation at low temperatures, with the colour of emission from the diisopropyl substituted analogues red shifted by the halogens in the order Cl (red) > Br (orange) > I (yellow). Emission from the diphenyl substituted analogues was dominated by the extended aromatic system and was largely invariant to the halogens. PMID:25230795

  6. Alleviative Effects of a Kampo (a Japanese Herbal) Medicine “Maoto (Ma-Huang-Tang)” on the Early Phase of Influenza Virus Infection and Its Possible Mode of Action

    PubMed Central

    Kataoka, Erika; Aoki, Yuka; Hokari, Rei

    2014-01-01

    A Kampo medicine, maoto, has been prescribed in an early phase of influenza-like illness and used for a treatment of influenza clinically in Japan these days. However, the efficacy of maoto against the virus infection remains to be elucidated. This study was conducted to evaluate the alleviative effects of maoto against early phase of influenza virus infection and its preliminary mode of actions through immune systems. When maoto (0.9 and 1.6 g/kg/day) was orally administered to A/J mice on upper respiratory tract infection of influenza virus A/PR/8/34 from 4 hours to 52 hours postinfection (p.i.) significant antipyretic effect was shown in comparison with water-treated control. Administration of maoto (0.8 and 1.3 g/kg/day) significantly decreased the virus titers in both nasal (NLF) and bronchoalveolar lavage fluids (BALF) at 52 hours p.i., and significantly increased the anti-influenza virus IgM, IgA, and IgG1 antibody titers in NLF, BALF, and serum, respectively. Maoto also increased significantly the influenza virus-bound IgG1 and IgM antibody titers in serum and the virus-bound IgM antibody titer in even the BALF of uninfected A/J mice. These results indicate that maoto exerts antipyretic activity in influenza virus-infected mice and virus reducing effect at an early phase of the infection through probably augmentation of the virus-bound natural antibodies. PMID:24778699

  7. The scope and results of selected epidemiological studies conducted at the National Institute of Hygiene in the years 1945-1989.

    PubMed

    Naruszewicz-Lesiuk, Danuta; Wysocki, Mirosław J

    2013-01-01

    The authors present the first article in the series concerning the scope ofresearch, scientific, practical, educational and other achievements of the National Institute of Hygiene (PZH) since 1945. This article is limited to discussing selected studies conducted in the field of epidemiology until the year 1989. The selection was based on PZH annual reports on the accomplishment of planned objectives and the literature positins listed in these reports, as well as other documents. The criterion for selection was how the scope of the research matched the epidemiological situation within a historical context. The authors chose research that yielded practical results which made an impact on the epidemiological situation, particularly concerning infectious diseases in Poland. The significance of epidemiological research of non-infectious diseases was also stressed. In addition, research that was considered by scientists in Poland and abroad as contributing to the development of medical methodology was included in the selection. PMID:24741919

  8. Fake "Returnee" Earns 4 Million through Fraudulent Marriages: More than Ten Women Fall for His Claims of Being a Boss and Possessing a House and Car

    ERIC Educational Resources Information Center

    Chinese Education and Society, 2005

    2005-01-01

    This article discusses the case of Wang Ruiliang. Ms. Huang filed a case against Wang Jun, alleging that he had defrauded her. Ms. Huang met a man named Wang Jun in April 2002 through a certain matrimonial agency. Before they had been together for very long, Wang Jun asked to borrow money from Ms. Huang, claiming that he was having difficulties in

  9. Fake "Returnee" Earns 4 Million through Fraudulent Marriages: More than Ten Women Fall for His Claims of Being a Boss and Possessing a House and Car

    ERIC Educational Resources Information Center

    Chinese Education and Society, 2005

    2005-01-01

    This article discusses the case of Wang Ruiliang. Ms. Huang filed a case against Wang Jun, alleging that he had defrauded her. Ms. Huang met a man named Wang Jun in April 2002 through a certain matrimonial agency. Before they had been together for very long, Wang Jun asked to borrow money from Ms. Huang, claiming that he was having difficulties in…

  10. Ru(ii)-dmso complexes containing azole-based ligands: synthesis, linkage isomerism and catalytic behaviour.

    PubMed

    Ferrer, ngrid; Fontrodona, Xavier; Rodrguez, Montserrat; Romero, Isabel

    2016-02-21

    The reaction of cis,fac-[RuCl2(dmso-S)3(dmso-O)], 1, with different azole (L) ligands leads to new [RuCl2(L)(dmso-S)3] compounds (L = CH3-pz-H, 2; NO2-pz-H, 3; CF3-pz-H, 4 and Br-Hind, 5). Complexes 2-5 have been characterized by analytical, spectroscopic and electrochemical techniques as well as by monocrystal X-ray diffraction analysis. Upon oxidation to Ru(iii) the complexes undergo linkage isomerization of a S-bound dmso ligand and the corresponding kinetic rates as well as the thermodynamic properties have been determined for compound 2 and also for the previously described [Ru(II)Cl2(pypz-H)(dmso-S)2] (pypz-H = 2-(3-pyrazolyl)pyridine), 6, from cyclic voltammetries performed at different scan rates. The exposure of compound 2 to visible light in acetonitrile produces the substitution of one dmso ligand by a solvent molecule generating a new compound, 2'. The irradiation of solutions of compounds 2 and 6 in chloroform leads in both cases to the substitution of one dmso by a chlorido ligand in parallel to the oxidation of Ru(ii) to Ru(iii) generating complexes 2'' and 6' respectively. The reactivity of compounds 2-6 has been tested with regard to the hydration of nitriles in water as a solvent, displaying in all cases good performance and selectivity for the corresponding amides. PMID:26781790

  11. Effects of ice storm on forest ecosystem of southern China in 2008 Shaoqiang Wang1, Lei Zhou1, Weimin Ju2, Kun Huang1 1Key Lab of Ecosystem Network Observation and Modeling, Institute of Geographical Sciences and Natural Resources Research, Beijing, 10010

    NASA Astrophysics Data System (ADS)

    Wang, Shaoqiang

    2014-05-01

    Evidence is mounting that an increase in extreme climate events has begun to occur worldwide during the recent decades, which affect biosphere function and biodiversity. Ecosystems returned to its original structures and functions to maintain its sustainability, which was closely dependent on ecosystem resilience. Understanding the resilience and recovery capacity of ecosystem to extreme climate events is essential to predicting future ecosystem responses to climate change. Given the overwhelming importance of this region in the overall carbon cycle of forest ecosystems in China, south China suffered a destructive ice storm in 2008. In this study, we used the number of freezing day and a process-based model (Boreal Ecosystem Productivity Simulator, BEPS) to characterize the spatial distribution of ice storm region in southeastern China and explore the impacts on carbon cycle of forest ecosystem over the past decade. The ecosystem variables, i.e. Net primary productivity (NPP), Evapotranspiration (ET), and Water use efficiency (WUE, the ratio of NPP to ET) from the outputs of BEPS models were used to detect the resistance and resilience of forest ecosystem in southern China. The pattern of ice storm-induced forest productivity widespread decline was closely related to the number of freezing day during the ice storm period. The NPP of forest area suffered heavy ice storm returned to normal status after five months with high temperature and ample moisture, indicated a high resilience of subtropical forest in China. The long-term changes of forest WUE remain stable, behaving an inherent sensitivity of ecosystem to extreme climate events. In addition, ground visits suggested that the recovery of forest productivity was attributed to rapid growth of understory. Understanding the variability and recovery threshold of ecosystem following extreme climate events help us to better simulate and predict the variability of ecosystem structure and function under current and future climate change.

  12. [Detection and identification of highly pathogenic bacteria within the framework of the EQADeBa project--Part I: Samples containing living pathogens].

    PubMed

    Zasada, Aleksandra A; Gierczy?ski, Rafa?; Rzeczkowska, Magdalena; Formi?ska, Kamila; Zacharczuk, Katarzyna; Rastawicki, Waldemar

    2011-01-01

    Bacillus anthracis, Yersinia pestis, Francisella tularensis, Brucella sp., Bulkholderia mallei are B. pseudomallei are highly pathogenic bacteria of potential bioterrorism risk. To support the early warning and rapid response capacity to ensure an effective reaction to bioterrorist attacks the international project "Establishment of Quality Assurances for Detection of Highly Pathogenic Bacteria of Potential Bioterrorism Risk" (EQADeBa) has been established. The aim of the project was establishment the network of European laboratories that possess a suitable infrastructure and experts and laboratory workers trained in detection and identification of the highly pathogenic bacteria. This work presents methods used in investigation of samples containing living pathogens and results obtained in Department of Bacteriology NIZP-PZH in the third international test organized within the framework of the EQADeBa. The test evaluated competence of laboratories in detection and identification of pathogens mentioned above. In the work methods used in other laboratories were discussed and the results were compared. Results of the test confirmed competence of NIZP-PZH in detection and identification of highly pathogenic bacteria covered by EQADeBa project. PMID:22184939

  13. Pyrazolylamidino ligands from coupling of acetonitrile and pyrazoles: a systematic study.

    PubMed

    Gómez-Iglesias, Patricia; Arroyo, Marta; Bajo, Sonia; Strohmann, Carsten; Miguel, Daniel; Villafañe, Fernando

    2014-12-01

    Mixed pyrazole-acetonitrile complexes, both neutral fac-[ReBr(CO)3(NCMe)(pz*H)] (pz*H = pzH, pyrazole; dmpzH, 3,5-dimethylpyrazole; or indzH, indazole) and cationic fac-[Re(CO)3(NCMe)(pz*H)2]A (A = BF4, ClO4, or OTf), are described. Their role as the only starting products to obtain final pyrazolylamidino complexes fac-[ReBr(CO)3(NH═C(Me)pz*-κ(2)N,N)] and fac-[Re(CO)3(pz*H)(NH═C(Me)pz*-κ(2)N,N)]A, respectively, is examined. Other products involved in the processes, such as fac-[ReBr(CO)3(pz*H)2], fac-[Re(CO)3(NCMe)(NH═C(Me)pz*-κ(2)N,N)]A, and fac-[Re(CO)3(pz*H)2(OTf)] are also described. Warming CD3CN solutions of fac-[Re(CO)3(NCMe)(pz*H)2]A at 40 °C gives cleanly the pyrazolylamidino complexes [Re(CO)3(pz*H)(NH═C(Me)pz*-κ(2)N,N)]A as the only products, pointing to an intramolecular process. This is confirmed by carrying out reactions in the presence of one equivalent of a pyrazole different from that coordinated, which affords complexes where the pyrazolylamidino ligand contains only the pyrazole previously coordinated. When the reactions lead to an equilibrium mixture of the final and starting products, the reverse reaction gives the same equilibrium mixture, which indicates that the coupling reaction of pyrazoles and nitriles to obtain pyrazolylamidino ligands is a reversible intramolecular process. A systematic study of the possible factors which may affect the reaction gives the following results: (a) the yields of the direct reactions are higher for lower temperatures; (b) the tendency of the pyrazoles to give pyrazolylamidino complexes follows the sequence indzH > pzH > dmpzH; and (c) the reaction rates do not depend on the nature of the anion even when a large excess is added. The presence of a small amount of aqueous solution of NaOH catalyzes the reaction. Thus, addition of 0.5-1% of NaOH (aq) to solutions of fac-[ReBr(CO)3(NCMe)(pz*H)] (in CD3CN) or fac-[Re(CO)3(NCMe)(pz*H)2]A (in CD3CN, CD3NO2 or (CD3)2CO) allowed the syntheses of the corresponding pyrazolylamidino complexes [ReBr(CO)3(NH═C(Me)pz*-κ(2)N,N)] or [Re(CO)3(pz*H)(NH═C(Me)pz*-κ(2)N,N)]A with better yields, more rapidly, and in milder conditions. PMID:25379945

  14. Ephedra and Its Application To Sport Performance: Another Concern for the Athletic Trainer?

    ERIC Educational Resources Information Center

    Powers, Michael E.

    2001-01-01

    Provides a rationale for the ergogenic claims regarding ma huang (ephedra), comparing these claims with data from searches of MEDLINE and SPORT Discus from 1970-00 and discussing the use of ephedra in athletic training. Results indicate that there are many serious side effects associated with using ma huang, and they far outweigh any possible…

  15. Improving Intercultural Education at Chinese Institutions from German Experience

    ERIC Educational Resources Information Center

    Huang, Lihe

    2015-01-01

    In this reflection paper, Lihe Huang describes his experience studying abroad in Germany as a visiting scholar. Through the well-designed introductory seminar and study tour arranged by the Alexander von Humboldt Foundation, which provided the grant for Huang's research on foreign languages teaching and intercultural education in Germany, he…

  16. Preface: Proceedings of the Colloidal Dispersions in External Fields II Conference (Bonn-Bad Godesberg, 31 March 2 April 2008)

    NASA Astrophysics Data System (ADS)

    Löwen, H.

    2008-10-01

    This special issue reflects the scientific programme of the International Colloidal Dispersions in External Fields Conference (CODEF II) that took place in Bonn-Bad Godesberg from 31 March-2 April 2008. This is the second conference in a series that started in 2004 when the first CODEF meeting was held. The proceedings of the first CODEF meeting were summarized in a previous special issue (Journal of Physics: Condensed Matter 16 (issue 38)). The present issue represents recent progress in this rapidly developing field. The CODEF meeting series is held in conjunction with the German-Dutch Transregional Collaborative Research Centre SFB TR6 with the title Physics of Colloidal Dispersions in External Fields. Scientists working within this network as well as international invited guest speakers contributed to these meetings. The contributions in this issue are organized according to the type of different fields applied namely: bulk (no external field) shear flow electric field magnetic and laser-optical field confinement We would like to thank the CODEF II sponsors (Deutsche Forschungsgemeinschaft and MWFZ Mainz) for their financial support. Furthermore, we thank IOP Publishing for their willingness to publish the proceedings of this conference as a special issue. Participants O Alarcón-Waess (Puebla), M Allen (Coventry), J L Arauz-Lara (San Luis Potosi), L Assoud (Düsseldorf), G K Auernhammer (Mainz), R Backofen (Dresden), M Balbás-Gambra (Munich), J Bammert (Bayreuth), M Baptista (Mainz), J-L Barrat (Lyon), M Bier (Utrecht), K Binder (Mainz), R Blaak (Düsseldorf), V Blickle (Stuttgart), D Block (Kiel), S Böhm (Düsseldorf), V Botan (Mainz), J P Bouchaud (Paris), J Brader (Konstanz), G Brambilla (Montpellier), W J Briels (Enschede), M Brinkmann (Göttingen), C Brunet (Paris), H-J Butt (Mainz), M A Camargo Chaparro (Düsseldorf), R Castañeda Priego (Guanajuato), J J Cerdà Pino (Frankfurt), A Chatterji (Jülich), M Chavez Paez (San Luis Potosi), A Chremos (Edinburgh), D Y H Chui (Mainz), D Deb (Graz), C Dellago (Vienna), J Dhont (Jülich), P Dillmann (Konstanz), G Dominguez (Leipzig), M Duits (Enschede), B Dünweg (Mainz), F Ebert (Konstanz), S Egelhaaf (Düsseldorf), E Eggen (Utrecht), R Eichhorn (Bielefeld), E Eiser (Cambridge), H B Eral (Enschede), A Erbe (Konstanz), L Filion (Utrecht), G Foffi (Lausanne), J Fornleitner (Vienna), K Franzrahe (Konstanz), D Frenkel (Cambridge), M Fuchs (Konstanz), G Fytas (Heraklion), P Garstecki (Warsaw), I Gazuz (Konstanz), N Geerts (Amsterdam), G Gompper (Jülich), E Gonzalez-Tovar (San Luis Potosi), I Götze (Jülich), S Grandner (Berlin), L Gránásy (London), C Gutsche (Leipzig), D Hajnal (Mainz), R Hanes (Düsseldorf), A Härtel (Düsseldorf), P Henseler (Konstanz), C Hertlein (Stuttgart), C Holm (Mainz), J Hoogenboom (Barcelona), P Hopkins (Bristol), J Horbach (Cologne), C-C Huang (Jülich), K Huang (Göttingen), S Huißmann (Düsseldorf), M Humar (Ljubljana), S Iacopini (Mainz), A Imhof (Utrecht), A Ivlev (Garching), K Jacobs (Saarbrücken), J Jakobi (Hannover), O Jansen (Düsseldorf), M Jenkins (Düsseldorf), J Jordanovic (Berlin), S Jungblut (Mainz), M Kahn (Vienna), T Kalwarczyk (Warsaw), K Kegler (Leipzig), P Keim (Konstanz), Z Keqin (Singapore), U F Keyser (Leipzig), T Köller (Mainz), K Kremer (Mainz), M Krüger (Konstanz), A Kuijk (Utrecht), P Lang (Jülich), M Laurati (Düsseldorf), W Lechner (Vienna), H Lehle (Stuttgart), P Leiderer (Konstanz), H Lekkerkerker (Utrecht), P Lettinga (Jülich), A Libal (San Mart), B Lonetti (Jülich), N J Lorenz (Mainz), H Löwen (Düsseldorf), H Maleki (Mainz), J-G Malherbe (Paris), M Marechal (Utrecht), G Maret (Konstanz), C Mayer (Rome), S Mazoyer (Konstanz), M McPhie (Jülich), M Medina-Noyola (San Luis Potosi), A Melzer (Greifswald), A Menéndez-Manjón (Hannover), R Messina (Düsseldorf), H Michiel (Utrecht), P Mishra (Düsseldorf), J Mixteco (Guanajuato), B Moser (Düsseldorf), G Nägele (Jülich), R R Netz (Munich), P Nielaba (Konstanz), E Noruzifar (Mainz), M Oettel (Mainz), O Otto (Leipzig), S Overduin (Düsseldorf), E C Oğuz (Düsseldorf), T Palberg (Mainz), G Pauschenwein (Vienna), G Pellicane (Messina), F Pesth (Mainz), P Pfleiderer (Mainz), D J Pine (New York), D Pini (Milan), H Reiber (Mainz), V Reshetnyak (Kiev), M Rex (Düsseldorf), M Ripoll (Jülich), M Roth (Mainz), P Royall (Bristol), M Rubin-Zuzic (Garching), T Schilling (Mainz), A Schmidt (Düsseldorf), M Schmiedeberg (Berlin), H J Schöpe (Mainz), S Schreiber (Bayreuth), B Schumann (Düsseldorf), F Sciortino (Rome), L Shapran-Reiber (Mainz), M Siebenbürger (Bayreuth), S P Singh (New Delhi), R Siquieri (Aachen), F Smallenburg (Utrecht), I Snook (Melbourne), M Sperl (Cologne), J Stellbrink (Jülich), E Stiakakis (Jülich), T Szymborski (Warsaw), H Tanaka (Tokyo), P Tierno (Barcelona), U Tkalec (Ljubljana), A Tsigkri (Jülich), T Tückmantel (Düsseldorf), C Valeriani (Edinburgh), A van Blaaderen (Utrecht), E van den Pol (Utrecht), J van Meel (Amsterdam), P van Oostrum (Utrecht), R van Roij (Utrecht), S van Teeffelen (Düsseldorf), L Verhoeff (Utrecht), E Vermolen (Utrecht), R Vink (Göttingen), P Virnau (Mainz), T Voigtmann (Cologne), D Vollmer (Mainz), G J Vroege (Utrecht), H R Vutukuri (Utrecht), C Walz (Konstanz), M Walz (Erlangen), D A Weitz (Harvard), J Wenk (Düsseldorf), R Wensink (London), F Weyßer (Konstanz), L Willner (Jülich), R G Winkler (Jülich), A Wynveen (Düsseldorf), A Wysocki (Düsseldorf), J Zausch (Mainz), J Zhao (Mainz), M Zietara (Konstanz), U Zimmermann (Düsseldorf), J Zwanikken (Utrecht).

  17. What Made Your Essay Successful? I "T.A.C.K.L.E.D" the Essay Question!

    ERIC Educational Resources Information Center

    Teo, Tze Kwang

    2015-01-01

    Teaching in Singapore, Tze Kwang Teo cannot conceive of a history teacher unfamiliar with the mnemonic "PEE" (or "PEEL") used to structure students' essays. Its ubiquity is testimony to its power, reminding students both to explain and to substantiate their claims. Yet, as Foster and Gadd have argued, its neat formulation can…

  18. Some useful invariants of quark mass matrices

    NASA Astrophysics Data System (ADS)

    Olechowski, Marek; Pokorski, Stefan

    1989-11-01

    Traces of commutators [Mun1, Mdn2] of powers of mass matrices provide a simple set of weak basis invariants which compactly summarizes the observed pattern of the quark mixing and can be used to study ``naturalness'' of various Ansätze for the quark mass matrices. Supported in part by the Polish research project CPBP 01.03.

  19. Langfristige Performance mit Thin Clients bei HSBC Trinkaus

    NASA Astrophysics Data System (ADS)

    HSBC Trinkaus nutzt Thin Clients als grafikstarke Desktops einer Citrix-basierenden Server Based Computing-Umgebung. Die neuen Dualview-Arbeitsplätze sind zuverlässiger, pflegeleichter und stromsparender als die bisherigen Terminal-PCs. Selbst die Administration erfolgt im Zweibildschirmbetrieb.

  20. Variable Input: What Sarah Reveals about Nonagreeing "Don't" and Theories of Root Infinitives

    ERIC Educational Resources Information Center

    Miller, Karen

    2013-01-01

    Two recent proposals link the use of nonagreeing "don't" to the Root Infinitive (RI) Stage. Guasti & Rizzi (2002) argue for a misset parameter involving how agreement is spelled out. Schütze (2010) proposes that Infl is underspecified in child language and that "do" surfaces to support the contracted clitic/affix…

  1. Mathematically rigorous formulation of the Fermi pseudopotential for higher-partial-wave scattering in arbitrary dimension

    SciTech Connect

    Stampfer, F.; Wagner, P.

    2010-05-15

    The Huang-Yang multipolar pseudopotential [see Huang and Yang, Phys. Rev. 105, 767 (1957); later revised by Huang, Statistical Mechanics (Wiley, New York, 1963)] is derived in a mathematically rigorous way using distribution theory in arbitrary dimension. For higher partial waves (i.e., all except s waves), the original pseudopotential contained wrong numerical factors in dimension 3, which were corrected only recently [see Derevianko, Phys. Rev. A 72, 044701 (2005); Stampfer and Wagner, J. Math. Anal. Appl. 342, 202 (2008)]. Here, we generalize the expression for the pseudopotential, in particular to even dimension, enabling the study of scattering processes in a large class of systems, especially in dimension 2.

  2. Luminescent rhenium(I) tricarbonyl complexes with pyrazolylamidino ligands: photophysical, electrochemical, and computational studies.

    PubMed

    Gómez-Iglesias, Patricia; Guyon, Fabrice; Khatyr, Abderrahim; Ulrich, Gilles; Knorr, Michael; Martín-Alvarez, Jose Miguel; Miguel, Daniel; Villafañe, Fernando

    2015-10-28

    New pyrazolylamidino complexes fac-[ReCl(CO)3(NH[double bond, length as m-dash]C(Me)pz*-κ(2)N,N)] (pz*H = pyrazole, pzH; 3,5-dimethylpyrazole, dmpzH; indazole, indzH) and fac-[ReBr(CO)3(NH[double bond, length as m-dash]C(Ph)pz*-κ(2)N,N)] are synthesized via base-catalyzed coupling of the appropriate nitrile with pyrazole, or via metathesis by halide abstraction with AgBF4 from a bromido pyrazolylamidino complex and the subsequent addition of LiCl. In order to study both the influence of the substituents present at the pyrazolylamidino ligand, and that of the "sixth" ligand in the complex, photophysical, electrochemical, and computational studies have been carried out on this series and other complexes previously described by us, of the general formula fac-[ReL(CO)3(NH[double bond, length as m-dash]C(R')pz*-κ(2)N,N)](n+) (L = Cl, Br; R' = Me, Ph, n = 0; or L = NCMe, dmpzH, indzH, R' = Me, n = 1). All complexes exhibit phosphorescent decays from a prevalently (3)MLCT excited state with quantum yields (Φ) in the range between 0.007 and 0.039, and long lifetimes (τ∼ 8-1900 ns). The electrochemical study reveals irreversible reduction for all complexes. The oxidation of the neutral complexes was found to be irreversible due to halido-dissociation, whereas the cationic species display a reversible process implying the ReI/ReII couple. Density functional and time-dependent density functional theory (TD-DFT) calculations provide a reasonable trend for the values of emission energies in line with the experimental photophysical data, supporting the (3)MLCT based character of the emissions. PMID:26389827

  3. 76 FR 31616 - Government-Owned Inventions; Availability for Licensing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-06-01

    .... Tiukinhoy-Laing SD, Huang S, Klegerman M, Holland CK, McPherson DD. Ultrasound-facilitated thrombolysis... J, Stone MJ, et al. Pulsed-high intensity focused ultrasound enhances thrombolysis in an in...

  4. Working Group 2 Summary:. Space Charge Effects in Bending Systems

    NASA Astrophysics Data System (ADS)

    Bohn, Courtlandt L.; Emma, Paul J.

    2000-12-01

    Participants in Working Group 2 included: Y. Batygin, C. Bohn, B. Carlsten, J. Ellison, P. Emma, Z. Huang, A. Kabel, R. Kishek, R. Li, P. Musumeci, S. Nagaitsev, J. Qiang, M. Reiser, A. Ruggerio, R. Warnock, and M. Zeitlin.

  5. 77 FR 59935 - Center for Scientific Review Notice of Closed Meetings

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-01

    ... applications. Place: Washington Plaza Hotel, 10 Thomas Circle NW., Washington, DC 20005. Contact Person: Jin... Circle NW., Washington, DC 20005. Contact Person: Jin Huang, Ph.D., Scientific Review Officer, Center...

  6. Workflow-Management für organisationsübergreifende Datenübertragung am Beispiel des E-Learning-Systems der TUM

    NASA Astrophysics Data System (ADS)

    Boursas, Latifa

    In diesem Paper werden im ersten Schritt die Voraussetzungen und Anforderungen für Workflow-Management zur Bereitstellung einer organisationsübergreifenden Datenübertragung ausgeführt. Weiter werden auf einfache Art und Weise die Grundlagen des Identity Managements (IDM) und der Provisionierung von Zielsystemen erläutert sowie die technischen Lösungsideen für die genannten Anforderungen eingeführt. Am Beispiel des E-Learning-Systems der TU München zeigen wir zwei Lösungsansätze. Zu jedem Lösungsansatz werden die technischen Workflows genauer betrachtet und der Funktionsumfang erläutert. Ein paar Uses Cases bei den Datenkonvertierungen, die sich auf die verschiedenen Identity-Management-Schnittstellen beziehen werden auch präsentiert. Am Ende schließt ein Vergleich der beiden Lösungsansätze die Analyse ab.

  7. Protection against aflatoxin-B1-induced liver mutagenesis by Scutellaria baicalensis.

    PubMed

    de Boer, Johan G; Quiney, Brendan; Walter, Patrick B; Thomas, Cynthia; Hodgson, Kimberley; Murch, Susan J; Saxena, Praveen K

    2005-10-15

    We have measured the inhibition of the mutagenicity of the mycotoxin aflatoxin-B(1) in the liver of the rat by plant material of Scutellaria baicalensis, or Huang-qin. The addition of one percent dried Huang-qin to the feed of the animals reduced the mutant frequency of a subsequent administration of aflatoxin-B1 by approximately 60 and 77%, respectively, for two different batches of the plant material. The addition of Huang-qin also increased the expression of the gene for glutathione S-transferase A5 subunit by 2.5-3.0-fold, and decreased expression of P450 cytochrome 3A2 by 1.8-2.0-fold. The greater increase of the expression of the GST gene may result in the protection shown by Huang-qin. The sensitivity of the hepatic mitochondria to swelling, a measure of the mitochondrial permeability transition, is increased significantly in animals that are on a diet containing Huang-qin. This may lead to increased sensitivity to apoptosis on treatment with toxic compounds. The two batches of Huang-qin material show differences in both chemical composition and preventive potential. This study demonstrates how a combination of generating and analysis of plant varieties together with a mammalian assay for efficacy may improve the search for better plant-based prevention of cancer initiation. PMID:16202794

  8. Algebraic solution of the Stein-Stein model for stochastic volatility

    NASA Astrophysics Data System (ADS)

    Sophocleous, C.; O'Hara, J. G.; Leach, P. G. L.

    2011-04-01

    We provide an algebraic approach to the solution of the Stein-Stein model for stochastic volatility which arises in the determination of the Radon-Nikodym density of the minimal entropy of the martingale measure. We extend our investigation to the case in which the parameters of the model are time-dependent. Our algorithmic approach obviates the need for Ansätze for the structure of the solution.

  9. Modeling the Pion Generalized Parton Distribution

    NASA Astrophysics Data System (ADS)

    Mezrag, C.

    2016-02-01

    We compute the pion Generalized Parton Distribution (GPD) in a valence dressed quarks approach. We model the Mellin moments of the GPD using Ansätze for Green functions inspired by the numerical solutions of the Dyson-Schwinger Equations (DSE) and the Bethe-Salpeter Equation (BSE). Then, the GPD is reconstructed from its Mellin moment using the Double Distribution (DD) formalism. The agreement with available experimental data is very good.

  10. Arbitrary-Order Hilbert Spectral Analysis: Theory and Application in Turbulence Research

    NASA Astrophysics Data System (ADS)

    Huang, Yongxiang; Schmitt, Francois

    2014-05-01

    Multiscale statistics are relevant in many phenomena since different spatial and temporal scales are involved. Meanwhile, there are intrinsically nonlinear and nonstationary on different scales in these multiscale phenomena. Traditional statistical methods, such as, Fourier power spectrum analysis, structure-function analysis, etc., are failed to handle the nonlinearity and nonstationarity of the collected data from either laboratory experiments or the real world observations. The Empirical Mode Decomposition (EMD) is proposed by N.E. Huang in 1998 to overcome some potential shortcomings of the traditional method to handle the nonlinearity and nonstationarity by combining the classical Hilbert spectral analysis (HSA). Later, we generalized this Hilbert-based method into an arbitrary-order version, namely arbitrary-order Hilbert spectral analysis, to characterize the scale invariant property of a scaling process in a joint frequency-physical domain. In this talk, we present first the basic idea of this Hilbert-based methodology. It is then validated by numerical experiments and is applied in different turbulent systems, e.g., Eulerian velocity, passive scalar turbulence, two-dimensional turbulence, etc., to show the efficiency of this Hilbert-based method. Reference 1. Huang Y, Schmitt F, Lu Z and Liu Y 2008 Europhys. Lett. 84, 40010. 2. Huang Y, Schmitt F, Lu Z and Liu Y 2009 J. Hydrol. 373, 103-111. 3. Huang Y, Schmitt F, Lu Z, Fougairolles P, Gagne Y and Liu Y 2010 Phys. Rev. E 82(2), 026319. 4. Huang Y, Schmitt F G, Hermand J P, Gagne Y, Lu Z and Liu Y 2011 Phys. Rev. E 84(1), 016208. 5. Huang Y, Biferale L, Calzavarini E, Sun C and Toschi F 2013 Phys. Rev. E 87, 041003(R). 6. Tan H.S., Huang Y. and Meng J.-P. 2014 Phys. Fluids 26, 015106.

  11. Ephedra and Its Application to Sport Performance: Another Concern for the Athletic Trainer?

    PubMed Central

    2001-01-01

    Objective: The ma huang herb, otherwise known as ephedra, has gained widespread popularity as an ergogenic supplement. With the sympathomimetic alkaloid ephedrine as its primary active ingredient, ma huang is marketed to reduce fatigue; increase strength, power, and speed; decrease reaction time; and improve body composition. Although numerous side effects have been associated with the use of ma huang, its popularity in athletes continues to grow. This review provides rationale for the ergogenic claims regarding ma huang and compares and contrasts those claims with data from scientifically controlled investigations. Data Sources: MEDLINE and SPORT Discus were searched from 1970 to 2000 using the key words ma huang, ephedra, and ephedrine in combination with humans, exercise, performance, and side effects. Data Synthesis: Ephedrine has been used alone or in combination with other drugs as an effective weight-loss agent. The weight loss has been attributed to thermogenic and lipolytic effects which, in combination with the central nervous system stimulating effects, have also resulted in its use as an ergogenic aid. Most of the scientific data, however, do not support manufacturers' ergogenic claims, and numerous side effects have been associated with ephedrine use. Thus, the safety and efficacy of ma huang as an ergogenic supplement must be questioned. Conclusions/Recommendations: It appears that the risks associated with the use of ma huang far outweigh any possible ergogenic benefits. Thus, it is extremely important that athletic trainers educate athletes on these issues so they can continue to perform at an optimum level in a safe and healthy manner. PMID:16558668

  12. Blue-emitting platinum(II) complexes bearing both pyridylpyrazolate chelate and bridging pyrazolate ligands: synthesis, structures, and photophysical properties.

    PubMed

    Chang, Sheng-Yuan; Chen, Jing-Lin; Chi, Yun; Cheng, Yi-Ming; Lee, Gene-Hsiang; Jiang, Chang-Ming; Chou, Pi-Tai

    2007-12-24

    A new Pt(II) dichloride complex [Pt(fppzH)Cl2] (1), in which fppzH = 3-(trifluoromethyl)-5-(2-pyridyl)pyrazole, was prepared by the treatment of a pyridylpyrazole chelate fppzH with K2PtCl4 in aqueous HCl solution. Complex 1 could further react with its parent pyrazole (pzH), 3,5-dimethylpyrazole (dmpzH), or 3,5-di-tert-butylpyrazole (dbpzH) to afford the monometallic [Pt(fppz)(pzH)Cl] (2), [Pt(fppz)(dmpzH)Cl] (3), [Pt(fppz)(dmpzH)2]Cl (4), or two structural isomers with formula [Pt(fppz)(dbpzH)Cl] (5a,b). Single-crystal X-ray diffraction studies of 2, 4, and 5a,b revealed a square planar Pt(II) framework, among which a strong interligand hydrogen bonding occurred between fppz and pzH ligands in 2. This interligand H-bonding is replaced by dual N-H...Cl interaction in 4 and both intermolecular N-H...O (with THF solvate) and N-H...Cl interaction in 5a,b, respectively; the latter are attributed to the bulky tert-butyl substituents that force the dbpzH ligand to adopt the perpendicular arrangement. Furthermore, complex 2 underwent rapid deprotonation in basic media to afford two isomeric complexes with formula [Pt(fppz)(mu-pz)]2 (6a,b), which are related to each other according to the spatial orientation of the fppz chelates, i.e., trans- and cis-isomerism. Similar reaction exerted on 3 afforded isomers 7a,b. Both 6a,b (7a,b) are essentially nonemissive in room-temperature fluid state but afford strong blue phosphorescence in solid state prepared via either vacuum-deposited thin film or 77 K CH2Cl2 matrix. As also supported by the computational approaches, the nature of emission has been assigned to be ligand-centered triplet pipi* mixed with certain metal-to-ligand charge-transfer character. PMID:18027932

  13. Electron-lattice coupling in ZnFe2O4/TiO2 nanocomposite films

    NASA Astrophysics Data System (ADS)

    Jin, Yunxia; Li, Guanghai; Zhang, Lide

    2005-02-01

    Electron-lattice (e-ph) coupling originated from the low-temperature photoluminescence in ZnFe2O4/TiO2 nanocomposite films has been studied. The purely linear character of the e-ph coupling is shown through the Huang-Rhys model within the Franck-Condon approximation. The interfacial coupling capability between the ZnFe2O4 nanoparticles and the TiO2 host lattice is characterized by the Huang-Rhys factors (S0) and the vibrational quantum energy (ℏΩ). It is found that the Huang-Rhys factors S0 increases with increasing the content of ZnFe2O4 in the TiO2 films and the vibrational energy ℏΩ is quite in agreement with that in the infrared spectra.

  14. Signal Processing Methods Monitor Cranial Pressure

    NASA Technical Reports Server (NTRS)

    2010-01-01

    Dr. Norden Huang, of Goddard Space Flight Center, invented a set of algorithms (called the Hilbert-Huang Transform, or HHT) for analyzing nonlinear and nonstationary signals that developed into a user-friendly signal processing technology for analyzing time-varying processes. At an auction managed by Ocean Tomo Federal Services LLC, licenses of 10 U.S. patents and 1 domestic patent application related to HHT were sold to DynaDx Corporation, of Mountain View, California. DynaDx is now using the licensed NASA technology for medical diagnosis and prediction of brain blood flow-related problems, such as stroke, dementia, and traumatic brain injury.

  15. New approach to the Yukawa puzzle

    SciTech Connect

    Branco, G.C.; Emmanuel-Costa, D.; Silva-Marcos, J.I.

    1997-07-01

    We do a systematic analysis of the question of the calculability of CKM matrix elements in terms of quark-mass ratios, within the framework of the hypothesis of the universality of strength for Yukawa couplings (USY), where all Yukawa couplings have equal moduli, and the flavor dependence is only in their phases. We use the fact that the limit m{sub u}=m{sub d}=0 is especially simple in the USY, to construct the various {ital Ans{umlt a}tze}. It is shown that the experimentally observed CKM matrix can be obtained within USY {ital Ans{umlt a}tze} corresponding to simple relations among phases of Yukawa couplings. Within the USY, one finds a natural explanation why Cabibbo mixing is significantly larger than the other CKM mixings. In the most successful of the USY {ital Ans{umlt a}tze}, one obtains, in leading order, {vert_bar}V{sub us}{vert_bar}={radical}(m{sub d}/m{sub s}), {vert_bar}V{sub cb}{vert_bar}={radical}(2)(m{sub s}/m{sub b}), {vert_bar}V{sub ub}{vert_bar}=(1/{radical}(2)){radical}(m{sub d}m{sub s}/m{sub b}{sup 2}), and {vert_bar}V{sub td}{vert_bar}=3{vert_bar}V{sub ub}{vert_bar}. We study the behavior of this USY {ital Ansatz} under the renormalization group. {copyright} {ital 1997} {ital The American Physical Society}

  16. Comparison of the effects of bisphenol A alone and in a combination with X-irradiation on sperm count and quality in male adult and pubescent mice.

    PubMed

    Dobrzyńska, Małgorzata M; Jankowska-Steifer, Ewa A; Tyrkiel, Ewa J; Gajowik, Aneta; Radzikowska, Joanna; Pachocki, Krzysztof A

    2014-11-01

    Bisphenol A (BPA) is employed in the manufacturing of epoxy, polyester-styrene, and polycarbonate resins, which are used for the production of baby and water bottles and reusable containers, food and beverage packing, dental fillings and sealants. The study was designed to examine the effects of 8-week exposure (a full cycle of spermatogenesis) to BPA alone and in a combination with X-irradiation on the reproductive organs and germ cells of adult and pubescent male mice. Pzh:Sfis male mice were exposed to BPA (5, 10, and 20 mg/kg) or X-rays (0.05 Gy) or to a combination of both (0.05 Gy + 5 mg/kg bw BPA). The following parameters were examined: sperm count, sperm motility, sperm morphology, and DNA damage in male gametes. Both BPA and X-rays alone diminished sperm quality. BPA exposure significantly reduced sperm count in pubescent males compared to adult mice, with degenerative changes detected in seminiferous epithelium. This may suggest a higher susceptibility of germ cells of younger males to BPA action. Combined BPA with X-ray treatment enhanced the harmful effect induced by BPA alone in male germ cells of adult males, whereas low-dose irradiation showed sometimes protective or additive effects in pubescent mice. PMID:23619965

  17. Molecular dynamics simulation studies of absorption in piperazine activated MDEA solution.

    PubMed

    Farmahini, Amir Hajiahmadi; Kvamme, Bjørn; Kuznetsova, Tatiana

    2011-07-28

    Development of more efficient solvent solutions for removal of CO(2) from natural gas and flue gases is a major task, which contributes to improved design of process plants and leads to decreased costs for its removal. Understanding the mechanisms of CO(2) absorption as well as analysis of undesired simultaneous processes is crucially important in this regard. In this work, we have applied Molecular Dynamics (MD) to investigate the absorption of CO(2) from a binary mixture of CO(2) and CH(4) into aqueous piperazine activated MDEA solution. The MD simulations were performed at a constant temperature of 298 K for five different systems with a loading factor of 0.07 to provide insight into molecular distribution in the amine solution and to enhance understanding of absorption mechanisms on the molecular scale. Force field parameters that were missing from the OPLS-AA force field, as well as charge distribution of piperazine (PZ), protonated piperazine (PZH(+)), piperazine carbamate (PZCOO(-)) and MDEA were obtained by QM calculations. The results of our simulations emphasize the importance of piperazine and piperazine carbamate in accelerating the absorption process. For the first time, we have shown the undesirable trapping of CH(4) by the amine solution and revealed that amine groups are mainly responsible for both absorption of CO(2) and the undesired trapping of CH(4). PMID:21691636

  18. Davydov Ansatz as an efficient tool for the simulation of nonlinear optical response of molecular aggregates

    NASA Astrophysics Data System (ADS)

    Sun, Ke-Wei; Gelin, Maxim F.; Chernyak, Vladimir Y.; Zhao, Yang

    2015-06-01

    We have developed a variational approach to the description of four-wave-mixing signals of molecular aggregates, in which the third-order response functions are evaluated in terms of the Davydov Ansätze. Our theory treats both singly and doubly excited excitonic states, handling the contributions due to stimulated emission, ground state bleach, and excited state absorption. As an illustration, we simulate a series of optical two-dimensional spectra of model J-aggregates. Our approach may become suitable for the computation of femtosecond optical four-wave-mixing signals of molecular aggregates with intermediate-to-strong exciton-phonon and exciton-exciton coupling strengths.

  19. Das unsichtbare Universum. An den Grenzen der modernen Astrophysik.

    NASA Astrophysics Data System (ADS)

    Field, G. B.; Chaisson, E. J.; Koch, B. P.

    German translation of the English original "The invisible Universe"; Boston 1985 (39.003.089).Contents: (1) Sichtbare und unsichtbare Strahlungen: Die Schlüssel zum Universum.(2) Der interstellare Raum: Die dunklen Reiche des Nachthimmels. (3) Sonne und Fixsterne: Schauplätze unsichtbarer Urgewalten. (4) Planeten, Leben und Intelligenz: Sind wir allein? (5) Galaxien: Die großen Bausteine der Natur. (6) Kosmische Urgewalten: Schwarze Löcher, Quasare und der Urgrund. (7) Das Universum: Die großräumigeStruktur des Weltalls. (8) Die Kräfte der Natur: An den Grenzen unseres Wissens.

  20. Was leistet ein Sportler? Kraft, Leistung und Energie im Muskel

    NASA Astrophysics Data System (ADS)

    Thaller, Sigrid; Mathelitsch, Leopold

    2006-01-01

    Der Leistungsbegriff ist im Sport weiter gefasst als in der Physik. In beiden Fällen liegt der Fokus jedoch auf einer pro Zeiteinheit erfolgten Energieumsetzung. Allerdings gibt die rein physikalische Leistung nicht immer Auskunft über den Energieumsatz der Muskeln. Die Muskelkraft hängt von der Kontraktionsgeschwindigkeit des Muskels ab. Ein Muskel verhält sich also anders als eine Feder. Für den Hochleistungssport müssen die Energieumsätze der Muskeln durch spezielle Trainings- und Nahrungsprogramme optimiert werden.

  1. Nichtlineare Rauschmodellierung von LC Tank VCOs

    NASA Astrophysics Data System (ADS)

    Thiessen, T.; Bremer, J.-K.; Mathis, W.

    2008-05-01

    Im Rahmen dieser Arbeit wird ein alternativer Ansatz zur Phasenrauschoptimierung von LC-Tank Oszillatoren (VCOs) unter Verwendung stochastischer Differentialgleichungen vorgestellt. Zunächst werden die linearen Ansätze von Leeson, Hajimiri und Lee analysiert und bewertet. Danach wird ein Konzept vorgestellt, mit dem man die Rauscheigenschaften von VCOs auf der Grundlage stochastischer Differentialgleichungen und Fokker-Planck-Gleichungen untersuchen kann. Ziel dieser Arbeit ist eine Beschreibung des Phasenrauschens auf der Basis einer nichtlinearen Rauschmodellierung, welche Parameter eines VCOs für eine Optimierung beinhaltet. Es wurde ein Matlab-Tool erstellt und die Funktionalität anhand von Simulationen verifiziert.

  2. High-frequency asymptotics of dielectric permittivity in supercooled liquids: Experimental data and conclusions of mode-coupling theory

    NASA Astrophysics Data System (ADS)

    Kondrin, M. V.

    2014-10-01

    The symptotic behavior of the correlation function predicted by Götze's mode-coupling theory agrees with experimentally observed relaxation processes and in most cases can be described by the phenomenological Cole-Davidson relationship. It is shown that the high-frequency behavior of the relaxation function is determined to a significant extent by processes related to the boundary frequency of propagation of elastic processes in liquids. A model is proposed that allows the relaxation processes to be described by unified approach in both normal and supercooled liquids.

  3. Stadtverkehrsplanung: Grundlagen, Methoden, Ziele

    NASA Astrophysics Data System (ADS)

    Steierwald, Gerd; Künne, Hans D.; Vogt, Walter

    Das in der Fachwelt als Standardwerk eingeschätzte Buch behandelt die Probleme und Lösungsansätze der modernen Stadtverkehrsplanung. Ausgehend von der Einbindung der Verkehrsplanung in die Stadtplanung wird dem Leser eine grundlegende Darstellung zu den Methoden und Verfahren dieses weiten Fachgebietes vermittelt. Die als Hochschullehrer und Praktiker anerkannten Autoren behandeln die Grundlagen und Ziele der Planung, die Analyse und Prognose der Verkehrsentwicklung -- insbesondere der Modellierung -- und liefern nach den heutigen Erkenntnissen eineumfassende Übersicht Über den Einfluss des Verkehrs auf alle Bereiche der humanen und natürlichen Umwelt einschließlich der Bewertung.

  4. Reassessment of Piwi binding to the genome and Piwi impact on RNA polymerase II distribution

    PubMed Central

    Lin, Haifan; Chen, Mengjie; Kundaje, Anshul; Valouev, Anton; Yin, Hang; Liu, Na; Neuenkirchen, Nils; Zhong, Mei; Snyder, Michael

    2015-01-01

    Drosophila Piwi was reported by Huang et al. (2013) to be guided by piRNAs to piRNA-complementary sites in the genome, which then recruits Heterochromatin Protein 1a and histone methyltransferase Su(Var)3-9 to the sites. Among additional findings, Huang et al. (2013) also reported Piwi binding sites in the genome and the reduction of RNA polymerase II in euchromatin but its increase in pericentric regions in piwi mutants. Marinov et al. (2015) disputed the validity of the Huang et al. bioinformatic pipeline that led to the last two claims. Here we report our independent reanalysis of the data using current bioinformatic methods. Our reanalysis agrees with Marinov et al. (2015) that Piwi’s genomic targets still remain to be identified, yet confirms the Huang et al. claim that Piwi influences RNA polymerase II distribution in the genome. This Response addresses the Marinov et al. (2015) Matters Arising, published concurrently in Developmental Cell. PMID:25805139

  5. American Council on Consumer Interests Annual Conference (35th, Baltimore, Maryland, March 29-April 1, 1989). The Proceedings.

    ERIC Educational Resources Information Center

    Carsky, Mary L., Ed.

    Among the 90 papers in this volume, education-related titles are as follows: "The Colston Warne Legacy" (Peterson); "Keeping a File on Survey Respondents" (Huang); "Aging-in-Place: Are Responses in the Best Interest of Elderly Consumers?" (Stum); "Low-Income Elderly in Health Maintenance Organizations: Enrollment, Satisfaction, & Understanding"…

  6. Deja Vu All over Again: Re-Revisiting the Conceptual Status of Early Word Learning: Comment on Smith and Samuelson (2006)

    ERIC Educational Resources Information Center

    Booth, Amy E.; Waxman, Sandra R.

    2006-01-01

    The authors assert that L. B. Smith and L. Samuelson's (2006; see record EJ750228) most recent critique of A. E. Booth, S. R. Waxman, and Y. T. Huang's (2005; see record EJ684979) work missed its mark, deflecting attention from the important theoretical difference between the two sets of authors' positions and focusing instead on imagined…

  7. Motivation and Commitment: Pre-Service Teachers from Hong Kong and Mainland China at a Training Institute in Hong Kong

    ERIC Educational Resources Information Center

    Gu, Mingyue; Lai, Chun

    2012-01-01

    Research indicates that historical and social backgrounds influence individuals' motivation to teach and their commitment to teaching (Gordon, 2000; Su, Hawkins, Huang & Zhao, 2001). This article reports on a comparative study exploring the motivation to teach and the commitment to teaching among non-local prospective student teachers from…

  8. VANADYL SULFATE INHIBITS NO PRODUCTION BY DIFFERENTIALLY REGULATING SERINE/THREONINE PHOSPHORYLATION OF ENOS

    EPA Science Inventory

    VANADYL SULFATE INHIBITS NO PRODUCTION BY DIFFERENTIALLY REGULATING SERINE/THREONINE PHOSPHORYLATION OF eNOS.

    Zhuowei Li, Jacqueline D. Carter, Lisa A. Dailey, Joleen Soukup, Yuh-Chin T. Huang. CEMALB, University of North Carolina and NHEERL, US EPA, Chapel Hill, North Ca...

  9. URBAN PARTICLE-INDUCED PULMONARY ARTERY CONSTRUCTION IS MEDIATED BY SUPEROXIDE PRODUCTION

    EPA Science Inventory

    URBAN PARTICLE-INDUCED PULMONARY ARTERY CONSTRICTION IS MEDIATED BY SUPEROXIDE PRODUCTION.Jacqueline D. Carter, Zhuowei Li, Lisa A. Dailey, Yuh-Chin T. Huang. CEMALB, University of North Carolina, and ORD, US EPA, Chapel Hill, North Carolina.

    Exposure to particulate matter...

  10. VANADL SULFATE INHIBITS NO PRODUCTION BY DIFFERENTIALLY REGULATING SERINE/THREONINE PHOSPHORYLATION OF ENOS

    EPA Science Inventory

    VANADYL SULFATE INHIBITS NO PRODUCTION BY DIFFERENTIALLY REGULATING SERINE/THREONINE PHOSPHORYLATION OF eNOS. Zhuowei Li, Jacqueline D. Carter, Lisa A. Dailey, Joleen Soukup, Yuh-Chin T. Huang. CEMALB, University of North Carolina and ORD, US EPA, Chapel Hill, North Carolina
    V...

  11. Fertilizer intensification and its impacts in China's HHH Plains

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The accomplishment of China’s food security by application of high rates of fertilizers has generated several controversies regarding the quality of soil and water resources. Thus, the objective of this article is to assess the effects and causes of the fertilizer intensification in the Huang Huai ...

  12. MODULATION OF HYPOXIC PULMONARY VASOCONSTRICTION BY ERYTHROCYTIC NITRIC OXIDE

    EPA Science Inventory

    Abstract
    American Heart Association 2001

    Modulation of Hypoxic Pulmonary Vasoconstriction by Erythrocytic NO
    McMahon TJ1, Gow AJ1, Huang YCT4, Stamler JS1,2,3
    Departments of Medicine1 and Biochemistry2, and Howard Hughes Medical Institute3,
    Duke University Med...

  13. Gaining Insight to Transfer of Training through the Lens of Social Psychology

    ERIC Educational Resources Information Center

    Weisweiler, Silke; Nikitopoulos, Alexandra; Netzel, Janine; Frey, Dieter

    2013-01-01

    The article deals with the question under which conditions people change their behavior through vocational trainings or not. Following the demand of more theory-driven investigations in transfer research (Blume, Ford, Baldwin, & Huang, 2010) we wish to add the perspective of social psychology. We therefore illustrate how well-known concepts from…

  14. EFFECTS OF METAL COMPONENTS IN CONCENTRATED AMBIENT AIR PARTICLES ON PULMONARY INJURY

    EPA Science Inventory

    EFFECTS OF METAL COMPONENTS IN CONCENTRATED AMBIENT AIR PARTICLES ON PULMONARY INJURY. Yuh-Chin Huang, Jackie Stonehuerner, Jackie Carter, Andrew J. Ghio, Robert B. Devlin. NHEERL, US EPA, RTP, NC.
    The mechanisms for cardiopulmonary morbidity associated with exposure to air po...

  15. Erratum to "A theoretical model of reversible adhesion in shape memory surface relief structures and its application in transfer printing" [J. Mech. Phys. Solids 77 (2015) 27-42

    NASA Astrophysics Data System (ADS)

    Xue, Yeguang; Zhang, Yihui; Feng, Xue; Kim, Seok; Rogers, John A.; Huang, Yonggang

    2016-03-01

    The publisher regrets that in the final published version, Yihui Zhang and Yonggang Huang are listed with incorrect affiliations. This information is obviously inconsistent with the contacting address of these two authors listed on the bottom of the title page. The correct affiliations are Yihui Zhang with Northwestern University and Tsinghua University and

  16. A Chinese Nurse's Socio-Cultural Experiences in Australia

    ERIC Educational Resources Information Center

    Huang, Yang

    2014-01-01

    In this article, the author expresses her thoughts and experiences on studying abroad. Yang Huang explains that studying overseas for international students means a lot--not only being away from home but also experiencing quite a few unexpected difficulties. Studying abroad is full of challenges for every student due to the language barrier,…

  17. CONTRIBUTION OF INSPIRATORY FLOW TO ACTIVATION OF EGFR, RAS, MAPK, ATF-2 AND C-JUN DURING LUNG STRETCH

    EPA Science Inventory

    Contribution of Inspiratory Flow to Activation of EGFR, Ras, MAPK, ATF-2 and c-Jun during Lung Stretch

    R. Silbajoris 1, Z. Li 2, J. M. Samet 1 and Y. C. Huang 1. 1 NHEERL, ORD, US EPA, RTP, NC and 2 CEMALB, UNC-CH, Chapel Hill, NC .

    Mechanical ventilation with larg...

  18. Author Affiliation Index: A New Approach to Marketing Journal Ranking

    ERIC Educational Resources Information Center

    Pan, Yue; Chen, Carl R.

    2011-01-01

    Previous research has adopted various methods to assess the relative quality of academic marketing journals. This study, as a replication and extension of Chen and Huang (2007), introduces the Author Affiliation Index (AAI) as an alternative approach to assessing marketing journal quality. The AAI is defined as the ratio of articles authored by…

  19. NITROTYROSINE ATTENUATES RSV-INDUCED INFLAMMATION IN AIRWAY EPITHELIAL CELLS

    EPA Science Inventory

    Nitrotyrosine attenuates RSV-induced inflammation in airway epithelial cells. Joleen Soukup, Zuowei Li, Susanne Becker and Yuh-Chin Huang. NHEERL, ORD, USEPA, RTP, North Carolina, CEMALB, University of North Carolina, Chapel Hill, North Carolina

    Nitrotyrosine (NO2Tyr) is a...

  20. Evaluating the Impact of Human Resource Development.

    ERIC Educational Resources Information Center

    1999

    These four papers are from a symposium on evaluating the impact of human resource development (HRD). "Pre-Job Training and the Earnings of High-Tech Employees in Taiwan" (Tung-Chun Huang) reports on a study that concludes that public training programs have no impact on participants' earnings in later jobs, but participation in private training…

  1. 75 FR 42757 - National Institute of General Medical Sciences; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-22

    ... HUMAN SERVICES National Institutes of Health National Institute of General Medical Sciences; Notice of... of Committee: National Institute of General Medical Sciences Special Emphasis Panel, Huang P01. Date..., National Institute of General Medical Sciences, National Institutes of Health, 45 Center Drive, Room...

  2. Development of methods for the field evaluation of Oobius agrili (Hymenoptera: Encyrtidae) in North America, a newly introduced egg parasitoid of the emerald ash borer (Coleoptera: Buprestidae)

    Technology Transfer Automated Retrieval System (TEKTRAN)

    A field study was conducted in forested plots near Lansing, Michigan in 2008 and 2009 to evaluate the newly introduced egg parasitoid, Oobius agrili Zhang and Huang (Hymenoptera: Encyrtidae), for control of the invasive emerald ash borer (EAB), Agrilus planipennis Fairmaire (Coleoptera: Buprestidae)...

  3. 78 FR 37540 - Ocean Transportation Intermediary License Applicants

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-21

    ..., CA 94607, Officers: Felise Langi, Chief Executive Member (QI), Malia I. Langi, Member, Application... Von Karman Avenue, Suite 1450, Irvine, CA 92612, Officer: Jo Ning Huang, Managing Member, Application..., Palo Alto, CA 94306, Officer: Xin You, Member/Manager (QI), Application Type: New OFF License....

  4. Proceedings of the Annual Meeting of the Association for Education in Journalism and Mass Communication (86th, Kansas City, Missouri, July 30-August 2, 2003). Communication Technology and Policy Division.

    ERIC Educational Resources Information Center

    2003

    The Communication Technology and Policy Division of the proceedings contains the following 15 papers: "Both Sides of the Digital Divide in Appalachia: Uses and Perceived Benefits of Internet Access" (Daniel Riffe); "Bridging Newsrooms and Classrooms: Preparing the Next Generation of Journalists for Converged Media" (Edgar Huang, Karen Davison,…

  5. American Council on Consumer Interests Annual Conference (35th, Baltimore, Maryland, March 29-April 1, 1989). The Proceedings.

    ERIC Educational Resources Information Center

    Carsky, Mary L., Ed.

    Among the 90 papers in this volume, education-related titles are as follows: "The Colston Warne Legacy" (Peterson); "Keeping a File on Survey Respondents" (Huang); "Aging-in-Place: Are Responses in the Best Interest of Elderly Consumers?" (Stum); "Low-Income Elderly in Health Maintenance Organizations: Enrollment, Satisfaction, & Understanding"

  6. JB6 Mouse Model

    Cancer.gov

    JB6 References 2004 Lin MH, Wang CJ, Huang HP, Chou MY, & Chou FP. The tumorigenic haracteristics of lime-piper betel quid-transformed JB6 cells. Arch Toxicol. 78(3): 167-73, 2004.  Abstract  Hou DX, Kai K, Li JJ, Lin S, Terahara N, Wakamatsu M, Fujii M,

  7. JB6 Mouse Model

    Cancer.gov

    JB6 References 1998 Cmarik JL, Li Y, Ogram SA, Reeves R & Colburn NH. Tumor promoter induces high mobility group HMG-Y protein expression in transformation-sensitive but not resistant cells. Oncogene 16: 3387-3396, 1998.  Abstract  Dong Z, Huang C, Ma WY,

  8. JB6 Mouse Model

    Cancer.gov

    JB6 References 2001 Berdyshev EV, Schmid PC, Krebsbach RJ, Hillard CJ, Huang C, Chen N, Dong Z, Schmid HH. Cannabinoid-receptor-independent cell signaling by N-acylethanolamines. Biochem J 360: 67-75, 2001.  Abstract  Full Text    Chung JY, Park JO, Phyu

  9. TRANSCRIPTION FACTOR ACTIVATION FOLLOWING EXPOSURE OF AN INTACT LUNG PREPARATION TO METALLIC PARTICULATE MATTER

    EPA Science Inventory

    TRANSCRIPTION FACTOR ACTIVATION FOLLOWING EXPOSURE OF AN INTACT LUNG PREPARATION TO METALLIC PARTICULATE MATTER

    James M. Samet1,2, Robert Silbajoris1, Tony Huang1 and Ilona Jaspers3

    1Human Studies Division, National Health and Environmental Effects Research Laborato...

  10. An improved method for monitoring parasitism and establishment of Oobius agrili (Hymenoptera: Encyrtidae) an egg parasitoid introduced for biological control of the emerald ash borer (Coleoptera: Buprestidae) in North America

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Oobius agrili Zhang and Huang (Hymenoptera: Encyrtidae) is a solitary egg parasitoid that is being released in the United States for biological control of the invasive emerald ash borer (EAB), Agrilus planipennis Fairmaire (Coleoptera: Buprestidae). Field and laboratory trials with “sentinel ash lo...

  11. Reassessment of Piwi binding to the genome and Piwi impact on RNA polymerase II distribution.

    PubMed

    Lin, Haifan; Chen, Mengjie; Kundaje, Anshul; Valouev, Anton; Yin, Hang; Liu, Na; Neuenkirchen, Nils; Zhong, Mei; Snyder, Michael

    2015-03-23

    Drosophila Piwi was reported by Huang et al. (2013) to be guided by piRNAs to piRNA-complementary sites in the genome, which then recruits heterochromatin protein 1a and histone methyltransferase Su(Var)3-9 to the sites. Among additional findings, Huang et al. (2013) also reported Piwi binding sites in the genome and the reduction of RNA polymerase II in euchromatin but its increase in pericentric regions in piwi mutants. Marinov et al. (2015) disputed the validity of the Huang et al. bioinformatic pipeline that led to the last two claims. Here we report our independent reanalysis of the data using current bioinformatic methods. Our reanalysis agrees with Marinov et al. (2015) that Piwi's genomic targets still remain to be identified but confirms the Huang et al. claim that Piwi influences RNA polymerase II distribution in the genome. This Matters Arising Response addresses the Marinov et al. (2015) Matters Arising, published concurrently in this issue of Developmental Cell. PMID:25805139

  12. INHIBITION OF RESPIRATORY SYNCYTIAL VIRUS (RSV)-INDUCED INFLAMMATION BY 3-NITROTYROSINE IN HUMAN BRONCHIAL EPITHELIAL CELLS

    EPA Science Inventory

    Inhibition of Respiratory Syncytial Virus (RSV)-Induced Inflammation by 3-Nitrotyrosine in Human Bronchial Epithelial Cells. J. M. Soukup, MPH 1, ZW. Li, MD 2 and YC. T. Huang, MD 1. 1 NHEERL, US Environmental Protection Agency, RTP, NC and 2 CEMALB, University of North Carolina,...

  13. JB6 Mouse Model

    Cancer.gov

    JB6 References 2006 Feng G, Ohmori Y, & Chang PL. Production of chemokine CXCL1/KC by okadaic acid through the nuclear factor-kappaB pathway. Carcinogenesis 27(1): 43-52, 2006.  Abstract Ding M, Huang C, Lu Y, Bowman L, Castranova V, & Vallyathan V. Invol

  14. Helicobacter pylori and Cancer

    MedlinePlus

    ... PubMed Abstract] Huang JQ, Sridhar S, Chen Y, Hunt RH. Meta-analysis of the relationship between Helicobacter pylori ... JQ, Zheng GF, Sumanac K, Irvine EJ, Hunt RH. Meta-analysis of the relationship between cagA seropositivity ...

  15. Single particle density of trapped interacting quantum gases

    SciTech Connect

    Bala, Renu; Bosse, J.; Pathak, K. N.

    2015-05-15

    An expression for single particle density for trapped interacting gases has been obtained in first order of interaction using Green’s function method. Results are easily simplified for homogeneous quantum gases and are found to agree with famous results obtained by Huang-Yang-Luttinger and Lee-Yang.

  16. Prescription for a pharmacyte

    SciTech Connect

    Hubbell, Jeffrey A.

    2015-06-10

    The efficient homing capacity of T cells may be used to deliver cell-associated, drug-laden nanoparticles to lymphoma cells that are resident in lymph nodes, increasing drug efficacy compared with drug encapsulated in free nanoparticles or free drug (Huang et al., this issue).

  17. Modern Foreign Languages: A Refereed International Journal of Linguistics and Applied Linguistics, 2001.

    ERIC Educational Resources Information Center

    Ying, Du, Ed; Zidong, Huang, Ed.

    2001-01-01

    These three issues contain the following articles written in Chinese: "On Conflated Theme in Systemic Functional Grammar" (Huang Guo-Wen); "A Cognitive Approach to the Conceptual Semantic Structures of Causation" (Cheng Qi-Long); "Falsifying the Internal Argument Hypothesis" (Zhao Yan-Chun); "Existential Sentences in English and Chinese: Towards a…

  18. Lifelong Learning for Social Development: A Review of Global Perspectives. Papers Presented at the International Conference on Lifelong Learning for Social Development (Kerala, India, August 13-15, 2002).

    ERIC Educational Resources Information Center

    2002

    This document contains 67 papers from an international conference on lifelong learning for social development. The following papers are among those included: "Lifelong Learning for Social Development" (John Dewar Wilson); "Building Networks of Lifelong Learning for Social Development outside the Center" (Shen-Tzay Huang, Chi chuan Li, An-Chi Li);…

  19. Implementing Ten-Minute Tickers in Secondary Physical Education Classes

    ERIC Educational Resources Information Center

    Lynott, Francis J., III; Hushman, Glenn; Dixon, Jonette; McCarthy, Andrea

    2013-01-01

    In the late 1980s and early 1990s, the time spent in moderate-to-vigorous physical activity (MVPA) during physical education class time started to be measured and questioned (Bar-Or, 1987; Lacey & LaMaster, 1990; McGing, 1989; Simons-Morton, Taylor, Snider, & Huang, 1993). Researchers suggested that the amount of time students spent in…

  20. 77 FR 24968 - National Library of Medicine; Notice of Closed Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-26

    ... HUMAN SERVICES National Institutes of Health National Library of Medicine; Notice of Closed Meeting... Committee: National Library of Medicine Special Emphasis Panel; Scholarly Works G13. Date: July 11, 2012... Medicine, 6705 Rockledge Drive, Suite 301, Bethesda, MD 20817. Contact Person: Zoe H. Huang, MD,...

  1. Videodisks Offer a Detailed Portrait of Qin, the First Chinese Emperor.

    ERIC Educational Resources Information Center

    Watkins, Beverly T.

    1992-01-01

    Project Emperor-I has issued two interactive videodiscs on China's first emperor, Qin Shi Huang Di. The videodiscs contain film footage from the archaeological excavation in China, images of artifacts, interviews with Qin specialists, and the full text of articles about the ancient burial site. Development of the videodiscs for scholars involved…

  2. Identity, Stress, and Resilience in Lesbians, Gay Men, and Bisexuals of Color

    ERIC Educational Resources Information Center

    Meyer, Ilan H.

    2010-01-01

    The author addresses two issues raised in Moradi, DeBlaere, and Huang's Major Contribution to this issue: the intersection of racial/ethnic and lesbian, gay, and bisexual (LGB) identities and the question of stress and resilience. The author expands on Moradi et al.'s work, hoping to encourage further research. On the intersection of identities,…

  3. Comment on {open_quotes}Method for calculating elastic scattering between two composite many-body systems at high energies{close_quotes}

    SciTech Connect

    Shalaby, A.S. El-Gogary, M.M.H. Hassan, M.Y.M.

    1997-11-01

    We comment on a paper by Huang Xiang Zhong, concerning the final analytical formula [Eq. (16)] for evaluating the scattering amplitude for collision between two composite nuclei {open_quotes}A{close_quotes} and {open_quotes}B.{close_quotes} {copyright} {ital 1997} {ital The American Physical Society}

  4. Modern Foreign Languages: A Refereed International Journal of Linguistics and Applied Linguistics, 2001.

    ERIC Educational Resources Information Center

    Ying, Du, Ed; Zidong, Huang, Ed.

    2001-01-01

    These three issues contain the following articles written in Chinese: "On Conflated Theme in Systemic Functional Grammar" (Huang Guo-Wen); "A Cognitive Approach to the Conceptual Semantic Structures of Causation" (Cheng Qi-Long); "Falsifying the Internal Argument Hypothesis" (Zhao Yan-Chun); "Existential Sentences in English and Chinese: Towards a

  5. Proceedings of the Annual Meeting of the Association for Education in Journalism and Mass Communication (81st, Baltimore, Maryland, August 5-8, 1998). Visual Communication.

    ERIC Educational Resources Information Center

    Association for Education in Journalism and Mass Communication.

    The Visual Communication section of the Proceedings contains the following 12 papers: "The Limits of Copyright Protection for the Use of Visual Works in Motion Pictures, Print Media, and Pop Art in the 1990s" (Andy Bechtel and Arati Korwar); "Afterthoughts on the Representational Strategies of the FSA Documentary" (Edgar Shaohua Huang); "Design…

  6. Evaluating the effect of temperature on microbial growth rate - the Ratkowsky and a Belehrádek type models

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The objective of this paper to conduct a parallel comparison of a new Belehradek-type growth rate (Huang model), Ratkowsky Square-root, and Ratkowsky Square equations as secondary models for evaluating the effect of temperature on the growth of microorganisms. Growth rates of psychrotrophs and meso...

  7. 75 FR 60461 - Agency Information Collection Activities: Proposed Collection; Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-30

    ... commonly used antibiotics (Huang 2007). This project is designed to evaluate the implementation of a... selecting the appropriate dose, duration and route of administration of antibiotics. Using antibiotics... each facility as well as by the antibiotic(s) targeted and will likely include some of the...

  8. ALTERATION OF CARDIAC ELECTRICAL ACTIVITY BY WATER-LEACHABLE COMPONENTS OF RESIDUAL OIL FLY ASH (ROFA)

    EPA Science Inventory

    Alteration of cardiac electrical activity by water-leachable components
    of residual oil fly ash (ROFA)

    Desuo Wang, Yuh-Chin T. Huang*, An Xie, Ting Wang

    *Human Studies Division, NHEERL, US EPA
    104 Mason Farm Road, Chapel Hill, NC 27599
    Department of Basic ...

  9. Family League 2011-12 Out of School Time Programs in Baltimore City

    ERIC Educational Resources Information Center

    Olson, Linda S.; Connolly, Faith; Kommajesula, Alok H.

    2013-01-01

    Out of School Time (OST) programs have been shown to promote positive personal, academic and social development (Huang, Gribbons, Kim, Lee, & Baker, 2000; Welsh et al., 2002). The Family League of Baltimore City works with partners to sponsor a range of after-school programs in Baltimore City Public Schools (City Schools) to provide healthy…

  10. Organized Labor at the Crossroads.

    ERIC Educational Resources Information Center

    Huang, Wei-Chiao, Ed.

    These papers are organized around the theme that labor unions in the United States, having suffered a precipitous decline in membership and influence, must reassess their past practices and strategies and seek new methods and solutions. Following an introduction by Wei-Chiao Huang, the document includes "Bargaining Realities: Responding to a…

  11. Technology Transfer/Commercialization Report

    NASA Technical Reports Server (NTRS)

    2002-01-01

    Contents include the following: (1) Who we are. (2) Technology opportunities and successes in 2002: Hilbert-Huang transform; new sensors via sol-gel-filled fiber optics; hierarchical segmentation software. (3) Activities in 2002: encouraging researcher involvement; inventorying new technologies; patenting Goddard technologies; promoting Goddard technologies; establishing new agreements;seeking and bestowing awards. (4) How to reach Goddard's: technology commercialization office.

  12. Activation of Phonological and Semantic Codes in Toddlers

    ERIC Educational Resources Information Center

    Mani, Nivedita; Durrant, Samantha; Floccia, Caroline

    2012-01-01

    What are the processes underlying word recognition in the toddler lexicon? Work with adults suggests that, by 5-years of age, hearing a word leads to cascaded activation of other phonologically, semantically and phono-semantically related words (Huang & Snedeker, 2010; Marslen-Wilson & Zwitserlood, 1989). Given substantial differences in…

  13. Retraction.

    PubMed

    2015-10-15

    This article has been retracted at the request of: Editor-in-Chief and Authors 'Cross-talk of alpha tocopherol-associated protein and JNK controls the oxidative stress-induced apoptosis in prostate cancer cells' by Baoyi Zhu, Xiaojuan Li, Yuying Zhang, Chunwei Ye, Yu Wang, Songwang Cai, Huaiqiu Huang, Yi Cai, Shuyuan Yeh, Zhenhua Huang, Ruihan Chen, Yiran Tao and Xingqiao Wen The above article, published online on 28 November 2012 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the authors, the journal Editor-in-Chief, Prof. Peter Lichter, and Wiley Periodicals, Inc. The Retraction has been agreed due to errors that were detected in Fig. 6b. Some images were duplicated and erroneously presented as unique. Although the authors firmly stand by the major conclusion of this paper, they believe the most responsible course of action is to retract it. Reference Zhu, B., Li, X., Zhang, Y., Ye, C., Wang, Y., Cai, S., Huang, H., Cai, Y., Yeh, S., Huang, Z., Chen, R., Tao, Y. and Wen, X. (2013), Cross-talk of alpha tocopherol-associated protein and JNK controls the oxidative stress-induced apoptosis in prostate cancer cells. Int. J. Cancer, 132: 2270-2282. doi: 10.1002/ijc.27927. PMID:26252812

  14. Classroom Learning Environment & Student Motivational Differences between Exemplary, Recognized, & Acceptable Urban Middle Level Schools

    ERIC Educational Resources Information Center

    Waxman, Hersh C.; Garcia, Andres; Read, Lisa L.

    2008-01-01

    One of the essential principles for improving middle grade education is to establish a safe and healthy school environment (Jackson & Davis, 2000; Price & Waxman, 2005). The overall quality of the school climate or school environment has been argued to be one of the central problems of urban schools (Waxman & Huang, 1997). Several studies, for…

  15. An Integrated Decision Model for Evaluating Educational Web Sites from the Fuzzy Subjective and Objective Perspectives

    ERIC Educational Resources Information Center

    Huang, Tony Cheng-Kui; Huang, Chih-Hong

    2010-01-01

    With advances in information and network technologies, lots of data have been digitized to reveal information for users by the construction of Web sites. Unfortunately, they are both overloading and overlapping in Internet so that users cannot distinguish their quality. To address this issue in education, Hwang, Huang, and Tseng proposed a group…

  16. An Integrated Decision Model for Evaluating Educational Web Sites from the Fuzzy Subjective and Objective Perspectives

    ERIC Educational Resources Information Center

    Huang, Tony Cheng-Kui; Huang, Chih-Hong

    2010-01-01

    With advances in information and network technologies, lots of data have been digitized to reveal information for users by the construction of Web sites. Unfortunately, they are both overloading and overlapping in Internet so that users cannot distinguish their quality. To address this issue in education, Hwang, Huang, and Tseng proposed a group

  17. Darwinische Kulturtheorie - Evolutionistische und "evolutionistische`` Theorien sozialen Wandels

    NASA Astrophysics Data System (ADS)

    Antweiler, Christoph

    Evolutionistische Argumentationen außerhalb der Biologie sind weit verbreitet. Wenn sie vertreten werden, heißt das mitnichten, dass sie notwendigerweise von darwinischen Argumenten geprägt sind. Wenn man Evolution und Kultur aus explizit darwinischer Perspektive zusammen bringt, bedeutet das noch lange nicht unbedingt Soziobiologie. Und es bedeutet sicherlich nicht Sozialdarwinismus. Dieser Beitrag soll einen Überblick der so genannten evolutionären Ansätze bzw. evolutionistischen Ansätze zu menschlichen Gesellschaften bzw. Kulturen geben. Es soll gezeigt werden, was in den Ansätzen analytisch zu trennen ist und was synthetisch zusammen gehört. Mein Beitrag ist nicht wissenschaftsgeschichtlich angelegt, sondern systematisch ausgerichtet und hat zwei Schwerpunkte (Antweiler 2008; Antweiler 2009b). Zum einen geht es um kausale Zusammenhänge von organischer Evolution und gesellschaftlichem Wandel. Auf der anderen Seite werden Analogien zwischen biotischer und kultureller Evolution erläutert, die als spezifische Ähnlichkeiten dieser beiden als grundsätzlich verschieden gesehenen Prozesse aufgefasst werden. Dadurch wird die Frage aufgeworfen, ob die Evolution von Organismen einerseits und die Transformation von Gesellschaften bzw. Kulturen andererseits, spezielle Fälle eines allgemeinen Modells von Evolution darstellen.

  18. Schlusswort

    NASA Astrophysics Data System (ADS)

    Pfeffer, Michael; Reinhardt, Andreas

    Im Rahmen des BMBF-Verbundprojektes ProMoLeS wurde bereits zu Projektbeginn der Industriearbeitskreis Montagelösungen für die Leistungselektronik" gegründet, welcher unter der organisatorischen und fachlichen Leitung vom bayerischen Cluster Leistungselektronik im ECPE e.V. eine Plattform für den Austausch zwischen Unternehmen der Leistungselektronik bietet. Ziel des Industriearbeitskreises ist es daher, mit neuen und innovativen Lösungen einen Beitrag zur Sicherung der Montagearbeitsplätze am Standort Deutschland zu leisten. Der Arbeitskreis richtet sich an Fach- und Führungskräfte von Unternehmen, die leistungselektronische Systeme oder deren Komponenten entwickeln und herstellen: Entwicklungsingenieure, Fertigungsplaner, Fertigungstechnologen, Fertigungsleiter, Arbeitsorganisatoren, Qualitätsbeauftragte sowie Wissenschaftler an Hochschulen, die auf den genannten Gebieten arbeiten. Ziel und Zweck des Arbeitskreises ist es, Wissen und Erfahrung auszutauschen, persönliche Kontakte von Fachleuten zwischen Unternehmen und wissenschaftlichen Einrichtungen zu verstärken, Kooperationen in dem Gebieten der Entwicklung, Fertigung, Logistik oder Qualifizierung aufzubauen, strategisch relevante Themen zu erkennen und gemeinsame Forschungs- und Entwicklungsprojekte zu initiieren. Damit soll die Wettbewerbsfähigkeit der Unternehmen verbessert und Arbeitsplätze am Standort gesichert werden.

  19. An analytical system for stable isotope analysis on carbon monoxide using continuous-flow isotope-ratio mass spectrometry

    NASA Astrophysics Data System (ADS)

    Pathirana, S. L.; van der Veen, C.; Popa, M. E.; Röckmann, T.

    2015-12-01

    A fully automated system for the determination of δ13C and δ18O in atmospheric CO has been developed. CO is extracted from an air sample and converted into carbon dioxide (CO2) using the Schütze reagent. The isotopic composition is determined with an isotope-ratio mass spectrometer (IRMS) technique. The entire system is continuously flushed with high-purity helium (He), the carrier gas. The blank signal of the Schütze reagent is ~ 4 nmol mol-1, or 1-3 % of the typical sample size. The repeatability is 0.1 ‰ for δ13C and 0.2 ‰ for δ18O. The peak area allows for simultaneous determination of the mole fraction with an analytical repeatability of ~ 0.7 nmol mol-1 for 100 mL of ambient air (185.4 nmol mol-1 of CO). An automated single measurement is performed in only 18 min, and the achieved time efficiency (and small volume of sample air) allows for repetitive measurements practically.

  20. An analytical system for studying the stable isotopes of carbon monoxide using continuous flow-isotope ratio mass spectrometry (CF-IRMS)

    NASA Astrophysics Data System (ADS)

    Pathirana, S. L.; van der Veen, C.; Popa, M. E.; Röckmann, T.

    2015-02-01

    In the atmosphere, carbon monoxide (CO) is the major sink for the hydroxyl radical (OH •), has multiple anthropogenic and natural sources and considerable spatial and seasonal variability. Measurements of CO isotopic composition are useful in constraining the strengths of its individual source and sink processes and thus its global cycle. A fully automated system for δ13C and δ18O analysis has been developed to extract CO from an air sample, convert CO into carbon dioxide (CO2) using the Schütze reagent, and then determine the isotopic composition in an isotope ratio mass spectrometer (IRMS). The entire system is continuously flushed with high-purity helium (He), the carrier gas. The blank signal of the Schütze reagent is only 1-3% of the typical sample size. The repeatability is 0.1‰ for δ13C and 0.2‰ for δ18O. The peak area allows simultaneous determination of the mole fraction with an analytical repeatability of ~0.7 nmol mol-1 for 100 mL of typical ambient air (185.4 nmol mol-1 of CO). A single, automated, measurement is performed in 18 min, so multiple measurements can be combined conveniently to improve precision.

  1. Calculation of deformation energies and conformations in lipid membranes containing gramicidin channels.

    PubMed Central

    Helfrich, P; Jakobsson, E

    1990-01-01

    In this paper we calculate surface conformation and deformation free energy associated with the incorporation of gramicidin channels into phospholipid bilayer membranes. Two types of membranes are considered. One is a relatively thin solvent-free membrane. The other is a thicker solvent-containing membrane. We follow the approach used for the thin membrane case by Huang (1986) in that we use smectic liquid crystal theory to evaluate the free energy associated with distorting the membrane to other than a flat configuration. Our approach is different from Huang, however, in two ways. One is that we include a term for surface tension, which Huang did not. The second is that one of our four boundary conditions for solving the fourth-order differential equation describing the free energy of the surface is different from Huang's. The details of the difference are described in the text. Our results confirm that for thin membranes Huang's neglect of surface tension is appropriate. However, the precise geometrical form that we calculate for the surface of the thin membrane in the region of the gramicidin channel is somewhat different from his. For thicker membranes that have to deform to a greater extent to accommodate the channel, we find that the contribution of surface tension to the total energy in the deformed surface is significant. Computed results for the shape of the deformed surface, the total energy in the deformed surface, and the contributions of different components to the total energy, are presented for the two types of membranes considered. These results may be significant for understanding the mechanisms of dimer formation and breakup, and the access resistance for ions entering gramicidin channels. PMID:1692748

  2. Silver(I) complexes of tris(pyrazolyl)borate ligands bearing six trifluoromethyl and three additional electron-withdrawing substituents.

    PubMed

    Jayaratna, Naleen B; Pardue, Daniel B; Ray, Sriparna; Yousufuddin, Muhammed; Thakur, Krishna G; Cundari, Thomas R; Dias, H V Rasika

    2013-11-21

    Sodium salts of two new tris(pyrazolyl)borates [HB(4-Cl-3,5-(CF3)2Pz)3](-) and [HB(4-(NO2)-3,5-(CF3)2Pz)3](-), which are not only highly fluorinated, but also loaded with additional electron-withdrawing substituents, have been synthesized by reacting 4-Cl-3,5-(CF3)2PzH or 4-(NO2)-3,5-(CF3)2PzH with NaBH4 under nitrogen in a solventless process, and isolated after a work up in tetrahydrofuran (THF) or diethyl ether (Et2O), as their THF or Et2O adducts. Metathesis of these sodium salts with AgOTf in THF leads to [HB(4-Cl-3,5-(CF3)2Pz)3]Ag(THF) and [HB(4-(NO2)-3,5-(CF3)2Pz)3]Ag(THF). The corresponding cis-cyclooctene (c-COE) complexes [HB(4-Cl-3,5-(CF3)2Pz)3]Ag(c-COE) and [HB(4-(NO2)-3,5-(CF3)2Pz)3]Ag(c-COE) were obtained by displacing THF with cis-cyclooctene. The related [HB(3,5-(CF3)2Pz)3]Ag(c-COE) can also be obtained via a similar process. X-ray crystal structures show that [HB(4-(R)-3,5-(CF3)2Pz)3]Ag(c-COE) (R = H, Cl, NO2) feature pseudo-tetrahedral silver sites supported by κ(3)-bound tris(pyrazolyl)borate ligands. [HB(4-(NO2)-3,5-(CF3)2Pz)3]Ag(c-COE) displays the smallest upfield shift of the alkene carbon peak (versus free alkene) followed by [HB(4-Cl-3,5-(CF3)2Pz)3]Ag(c-COE) and [HB(3,5-(CF3)2Pz)3]Ag(c-COE). Experimental and computational data indicate very electron poor silver(I) sites in all three [HB(4-(R)-3,5-(CF3)2Pz)3]Ag(c-COE) adducts with minimal Ag → (cis-cyclooctene) backbonding. Although the impact of R (H, Cl, NO2) on the alkene carbon chemical shift of these adducts and the olefin π/π* populations is small, the (13)C NMR chemical shifts and NBO analysis suggest that [HB(4-(NO2)-3,5-(CF3)2Pz)3]Ag(c-COE) possesses the most electrophilic metal site, which correlates with the pKa values of the free pyrazoles. [HB(4-(R)-3,5-(CF3)2Pz)3]Ag(c-COE) adducts effectively catalyze the insertion of the carbene moiety of ethyl diazoacetate into C-H bonds of 2,3-dimethylbutane. The [HB(4-(NO2)-3,5-(CF3)2Pz)3]Ag(c-COE) catalyst shows a higher selectivity for primary C-H bonds compared to the reactions catalyzed by [HB(3,5-(CF3)2Pz)3]Ag(c-COE). PMID:24013162

  3. Conversion of core oxos to water molecules by 4e-/4H+ reductive dehydration of the Mn4O2(6+) core in the manganese-oxo cubane complex Mn4O4(Ph2PO2)6: a partial model for photosynthetic water binding and activation.

    PubMed

    Ruettinger, W F; Dismukes, G C

    2000-03-01

    Reaction of the Mn4O4(6+) "cubane" core complex, Mn4O4L6 (1) (L = diphenylphosphinate, Ph2PO2-), with a hydrogen atom donor, phenothiazine (pzH), forms the dehydrated cluster Mn4O2L6 (2), which has lost two mu-oxo bridges by reduction to water (H2O). The formation of 2 was established by electrospray mass spectrometry, whereas FTIR spectroscopy confirmed the release of water molecules into solution during the reduction of 1. UV-vis and EPR spectroscopies established the stoichiometry and chemical form of the pzH product by showing the production of 4 equiv of the neutral pz radical. By contrast, the irreversible decomposition of 1 to individual Mn(II) ions occurs if the reduction is performed using electrons provided by various proton-lacking reductants, such as cobaltocene or electrochemical reduction. Thus, cubane 1 undergoes coupled four-electron/four-proton reduction with the release of two water molecules, a reaction formally analogous to the reverse sequence of the steps that occur during photosynthetic water oxidation leading to O2 evolution. 1H NMR of solutions of 2 reveal that all six of the phosphinate ligands exhibit paramagnetic broadening, due to coordination to Mn ions, and are magnetically equivalent. A symmetrical core structure is thus indicated. We hypothesize that this structure is produced by the dynamic averaging of phosphinato ligand coordination or exchange of mu-oxos between vacant mu-oxo sites. The paramagnetic 1H NMR of water molecules in solution shows that they are able to freely exchange with water molecules that are bound to the Mn ion(s) in 2, and this exchange can be inhibited by the addition of coordinating anions, such as chloride. Thus, 2 possesses open or labile coordination sites for water and anions, in contrast to solutions of 1, which reveal no evidence for water coordination. Complex 2 exhibits greater paramagnetism than that of 1, as seen by 1H NMR, and it possesses a broad (440 G wide) EPR absorption, centered at g = 2, that follows a Curie-Weiss temperature dependence (10-40 K) and is visible only at low temperatures, compared to EPR-silent 1. Its comparison to a spin-integration standard reveals that 2 contains 2 equiv of Mn(II), which is in agreement with the formal oxidation state of 2Mn(II)2Mn(III) that was derived from the titration. The EPR and NMR data for 2 are consistent with a loss of two of the intermanganese spin-exchange coupling pathways, versus 1, which results in two "wingtip" Mn(II) S = 5/2 spins that are essentially magnetically uncoupled from the diamagnetic Mn2O2 base. Bond-enthalpy data, which show that O2 evolution via the reaction 1-->2 + O2, is strongly favored thermodynamically but is not observed in the ground state due to an activation barrier, are included. This activation barrier is hypothesized to arise, in part, from the constraining effect of the facially bridging phosphinate ligands. PMID:12526383

  4. Coronary artery aneurysm and thrombosis following chronic ephedra use.

    PubMed

    Flanagan, Casey M; Kaesberg, Julie L; Mitchell, Eric S; Ferguson, Michael A; Haigney, Mark C P

    2010-02-18

    Ephedra, also known as Ma Huang, was commonly used to enhance athletic performance, "fat burning", and weight loss before its removal from the United States in April 2004 due to acute adverse health reactions including lethal arrhythmias, stroke, vasoconstriction, and myocardial infarction. We report the case of a 29-year-old patient with acute myocardial infarction, secondary to coronary artery aneurysms and thrombosis who reported use of Ma Huang, Xenadrine(r)RFA, and Hydroxycut at recommended dosages for a combined total of approximately 2 years. Other causes of coronary artery aneurysm and hypercoagulability were ruled out. Our case exemplifies the long-term (as opposed to acute) danger of ephedrine products and the first case of coronary artery aneurysm associated with its use. PMID:18718687

  5. Binarization of Gray-Scaled Digital Images Via Fuzzy Reasoning

    NASA Technical Reports Server (NTRS)

    Dominquez, Jesus A.; Klinko, Steve; Voska, Ned (Technical Monitor)

    2002-01-01

    A new fast-computational technique based on fuzzy entropy measure has been developed to find an optimal binary image threshold. In this method, the image pixel membership functions are dependent on the threshold value and reflect the distribution of pixel values in two classes; thus, this technique minimizes the classification error. This new method is compared with two of the best-known threshold selection techniques, Otsu and Huang-Wang. The performance of the proposed method supersedes the performance of Huang- Wang and Otsu methods when the image consists of textured background and poor printing quality. The three methods perform well but yield different binarization approaches if the background and foreground of the image have well-separated gray-level ranges.

  6. Binarization of Gray-Scaled Digital Images Via Fuzzy Reasoning

    NASA Technical Reports Server (NTRS)

    Dominquez, Jesus A.; Klinko, Steve; Voska, Ned (Technical Monitor)

    2002-01-01

    A new fast-computational technique based on fuzzy entropy measure has been developed to find an optimal binary image threshold. In this method, the image pixel membership functions are dependent on the threshold value and reflect the distribution of pixel values in two classes; thus, this technique minimizes the classification error. This new method is compared with two of the best-known threshold selection techniques, Otsu and Huang-Wang. The performance of the proposed method supersedes the performance of Huang-Wang and Otsu methods when the image consists of textured background and poor printing quality. The three methods perform well but yield different binarization approaches if the background and foreground of the image have well-separated gray-level ranges.

  7. Use of the moon and the large space telescope as an extrasolar planet detection system

    NASA Technical Reports Server (NTRS)

    Matloff, G. L.; Fennelly, A. J.

    1974-01-01

    Roman (1959), Spitzer (1962), and Huang (1973) have discussed photometric detection of extrasolar planets using a 3-m space telescope such as the Large Space Telescope (LST). A space telescope could be an extrasolar planet detection system if used in conjunction with an occulter placed 10,000 km in front of the telescope. The occulter would reduce the amount of light received from the star under observation. For a semi-infinite plane occulter 10,000 km in front of the telescope, Spitzer and Huang's results indicate that a Jupiter-like planet would be observed with a signal/noise of 1.00, for observations at 0.4 micron using a 3-m telescope like the LST.

  8. Approximation of nonnegative functions by means of exponentiated trigonometric polynomials

    NASA Astrophysics Data System (ADS)

    Fasino, Dario

    2002-03-01

    We consider the problem of approximating a nonnegative function from the knowledge of its first Fourier coefficients. Here, we analyze a method introduced heuristically in a paper by Borwein and Huang (SIAM J. Opt. 5 (1995) 68-99), where it is shown how to construct cheaply a trigonometric or algebraic polynomial whose exponential is close in some sense to the considered function. In this note, we prove that approximations given by Borwein and Huang's method, in the trigonometric case, can be related to a nonlinear constrained optimization problem, and their convergence can be easily proved under mild hypotheses as a consequence of known results in approximation theory and spectral properties of Toeplitz matrices. Moreover, they allow to obtain an improved convergence theorem for best entropy approximations.

  9. Discovery of a second species of Aesalini from Taiwan, with description of the new species of the genus Echinoaesalus Zelenka, 1993 (Coleoptera: Lucanidae).

    PubMed

    Huang, Hao; Chen, Chang-Chin

    2015-01-01

    Echinoaesalus chungi Huang & Chen, new species is described from Pingtung, Taiwan. It is the second species of the tribe Aesalini known from Taiwan. This new species is similar to the Bornean species Echinoaesalus arayai Huang & Imura, 2011, but can be distinguished mainly by the smaller size of the entire body, the laterally hooked sulcus on mentum of male, the separated sulci on mentum of female, the bristles inserted anteriorly in the wall of the punctures on dorsal surface of the body, the 9th abdominal segment of male with relatively larger paired pleurites, the medial lobe of parameres with weakly pigmented dorsal surface on distal half and with the pigmented distal sclerite interrupted on dorsal surface, and female genitalia with longer styli, thinner hemisternites and shorter bursa copulatrix. A key to the males of Echinoaesalus species is given. Female genitalia are described in detail for the new species and Echinoaesalus arayai. PMID:25781244

  10. Identification of the flavonoids in mungbean (Phaseolus radiatus L.) soup and their antioxidant activities.

    PubMed

    Li, He; Cao, Dongdong; Yi, Jianyong; Cao, Jiankang; Jiang, Weibo

    2012-12-15

    Mung bean soup (MBS) has been traditionally taken as a kind of health food in China. To learn the mechanisms underlying its health benefits, antioxidant capacities of the soup prepared with three cultivars of mung bean were measured. The highest DPPH radical scavenging or ferric reducing activity was observed in soup of mung bean cv. Huang. The MBS of cv. Huang and Mao exhibited higher ABTS(+) reducing activities than MBS of cv. Ming. The two major flavonoids in the MBS were purified and identified as vitexin and isovitexin, respectively. Modeling samples containing vitexin and isovitexin at the same levels as them in the MBS were prepared to assess their antioxidant contributions in the MBS. Our results showed that antioxidant capacities of the MBS mainly derived from vitexin and isovitexin, these flavonoids accounted for the most of total DPPH radicals scavenging, ferric reducing and ABTS(+) reducing scavenging activities in MBS of all the three cultivars. PMID:22980894

  11. Nonlocal reactive transport in heterogeneous dual-porosity media with rate-limited sorption and interregional mass diffusion

    NASA Astrophysics Data System (ADS)

    Huang, Hai; Hu, Bill X.

    2001-03-01

    Huang and Hu [2000] developed a nonlocal, first-order, Eulerian theory for the mean concentration of a conservative tracer in a dual-porosity medium. Here the results of Huang and Hu are extended to reactive chemical transport under linear nonequilibrium sorption in both mobile and immobile zones. Similar to Huang and Hu [2000], a two-zone, mobile and immobile, model [van Genuchten and Wierenga, 1976] is adapted to account for the interregional mass transfer. Hydraulic conductivity in the mobile zone, sorption coefficients in both zones, and interregional mass diffusion rate are all assumed to be spatial random variables to account for the inherent spatial variability of physical and chemical properties of a natural medium. The analytical solution for mean concentration in mobile water is given explicitly in Fourier-Laplace space and numerically converted to real space via a fast Fourier transform method. The results are simplified to conservative transport in a dual-porosity medium [Huang and Hu, 2000] and reactive transport in a one-zone model [Hu et al., 1995] under appropriate conditions. The solution provides a tool to investigate the validity of an "effective sorption" method, where various chemical sorption and physical mass transfer processes are treated as a sorption process with effective sorption parameters. This study shows that chemical sorption and interregional mass diffusion may be lumped together as an effective sorption process under specific conditions. Generally speaking, however, such simplification will lead to a significant error in prediction of the plume evolution, especially at late travel time. It is also shown that randomness of the interregional mass transfer process will significantly enhance the plume spreading and lead to a more negatively skewed plume.

  12. Goals reconfigure cognition by modulating predictive processes in the brain.

    PubMed

    Pezzulo, Giovanni

    2014-04-01

    I applaud Huang & Bargh's (H&B's) theory that places goals at the center of cognition, and I discuss two ingredients missing from that theory. First, I argue that the brains of organisms much simpler than those of humans are already configured for goal achievement in situated interactions. Second, I propose a mechanistic view of the "reconfiguration principle" that links the theory with current views in computational neuroscience. PMID:24775142

  13. Bar the windows: an optimized strategy to survive drought and salt adversities

    PubMed Central

    Song, Xian-Jun; Matsuoka, Makoto

    2009-01-01

    Hydrogen peroxide (H2O2) is a central modulator of stomatal closure. It remains unknown, however, how the upstream regulation of H2O2 homeostasis operates. In this issue of Genes & Development, Huang and colleagues (pp. 1805–1817) report that a novel C2H2-type transcription factor, drought and salt tolerance (DST), mediates H2O2-induced stomatal closure and abiotic stress tolerance. PMID:19651983

  14. Notes on the genus Echinoaesalus Zelenka, 1993 (Coleoptera: Lucanidae), with the description of a new species from the Malay Peninsula.

    PubMed

    Huang, Hao; Bartolozzi, Luca; Chen, Chang-Chin

    2015-01-01

    Echinoaesalus cechovskyi new species is described from the Malay Peninsula. Echinoaesalus hidakai borneoensis Huang & Imura, 2011 is elevated to the species level as E. borneoensis new status. The male or female genitalia of Echinoaesalus timidus (Krikken, 1975), E. hidakai (Araya, Kon, & Johki, 1993), E. borneoensis, and E. sabahensis Zelenka, 1994 are described and illustrated for the first time. The intraspecific variation of E. timidus is discussed. PMID:26624641

  15. Bearing Damage Detection of BLDC Motors Based on Current Envelope Analysis

    NASA Astrophysics Data System (ADS)

    Lee, Chun-Yao; Hsieh, Yu-Hua

    2012-12-01

    This paper proposes current envelope analysis (CEA) to analyze bearing fault signals in brushless direct current (BLDC) motors, and back propagation neural networks (BPNN) to automatically identify bearing faults. We made sample motors which contained different types of fault, recorded the current signals, and extracted the current features using CEA and Hilbert Huang transform (HHT) for BPNN fault identification. The results indicate that this approach can efficiently identify bearing faults in BLDC motors.

  16. Tyrosyl phosphorylation toggles a Runx1 switch

    PubMed Central

    Neel, Benjamin G.; Speck, Nancy A.

    2012-01-01

    The Runx1 transcription factor is post-translationally modified by seryl/threonyl phosphorylation, acetylation, and methylation that control its interactions with transcription factor partners and epigenetic coregulators. In this issue of Genes & Development, Huang and colleagues (pp. 15871601) describe how the regulation of Runx1 tyrosyl phosphorylation by Src family kinases and the Shp2 phosphatase toggle Runx1's interactions between different coregulatory molecules. PMID:22802526

  17. STRESS ANNEALING INDUCED DIFFUSE SCATTERING FROM Ni3(Al,Si) PRECIPITATES

    SciTech Connect

    Barabash, Rozaliya; Ice, Gene E; Karapetrova, Evgenia; Zschack, P.

    2012-01-01

    Diffuse scattering caused by L12 type Ni3 (Al,Si) precipitates after stress annealing of Ni-Al-Si alloys is studied. Experimental reciprocal space maps are compared to the theoretical ones. Oscillations of diffuse scattering due to Ni3 (Al,Sc) precipitates are observed. Peculiarities of diffuse scattering in asymptotic region as compared to Huang scattering region are discussed. Coupling between the stress annealing direction and the precipitate shape is demonstrated.

  18. Control of preweaning diarrhea in piglets by acupuncture and Chinese medicine.

    PubMed

    Lin, J H; Lo, Y Y; Shu, N S; Wang, J S; Lai, T M; Kung, S C; Chan, W W

    1988-01-01

    Preweaning diarrhea in piglets is a very common disease. Even thought vaccination and antibiotics are used widely for controlling the disease nowadays, it is still a serious production problem. Therefore, the search for a new medication that is both cheaper and more effective is of major importance. During the last year, acupuncture and Chinese medicine have been evaluated for this purpose. The results are summarized as follows: 1) Oral administration of 0.5 g of Ko-ken-huang-lien-huang-chin-tang (pueraria, coptis, scute and licorice combination) to piglets at 1 day old was effective in reducing incidence of infection (P less than 0.1) and increasing the body weight gain (P less than 0.05) during the first 10 days of life. Gentamycin or aqua-acupuncture at day 1 of life had no prophylactic value. 2) Piglets with preweaning diarrhea were treated by aqua-acupuncture at Chang-Chiang point (VG 1, or so called Chiao-Chao in traditional pig charts) with 0.2 ml of 3% saline, or by oral administration of 0.5 g of Ko-ken-huang-lien-huang-chin-tang or by injection of gentamycin (10 mg/piglet) twice a day for 1-3 days. These treatments significantly reduced the duration of illness (P less than 0.01) when compared with the control groups which received 0.5 g lactose orally. These results indicate that both acupuncture treatment and Chinese medicine have a high clinical value for controlling piglet diarrhea. PMID:3218634

  19. High grain, low noise organic and nanoelectronic photodetectors (Presentation Recording)

    NASA Astrophysics Data System (ADS)

    Huang, Jinsong

    2015-08-01

    The dramatically reduction of cost of photodetectors without comprising their performance will enable new applications in many fields. In this talk, I will brief our progress in the development of sensitive photodetectors/photon counters using low-cost solution processable organic and nano-electronic materials. Four types of device structures will be compared in terms of device gain, noise, sensitivity, response speed and linear dynamic range: 1) traditional diode structure, 2) a structure combine the photodiode and photoconductor through the interface trap triggered secondary charge injection, 3) an organic phototransistor that has combined photoconductive gain and photovoltaic gain, and 4) quantum dots modulated transistor channel conductance. Broad response spectrum from UV to NIR will be demonstrated, and active material limited performance will be discussed. Solution-Processed Nanoparticle Super-Float-Gated Organic Field-Effect Transistor as Un-cooled Ultraviolet and Infrared Photon Counter Yongbo Yuan, Qingfeng Dong, Bin Yang, Fawen Guo, Qi Zhang, Ming Han, and Jinsong Huang*, Scientific Reports, 3, 2707 (2013) A nanocomposite ultraviolet photodetector enabled by interfacial trap-controlled charge injection Fawen Guo, Bin Yang, Yongbo Yuan, Zhengguo Xiao, Qingfeng Dong, Yu Bi, and Jinsong Huang*, Nature Nanotechnology, 7, 798-802, (2012) Large Gain, Low Noise Nanocomposite Ultraviolet Photodetectors with a Linear Dynamic Range of 120 dB Yanjun Fang, Fawen Guo,Zhengguo Xiao, Jinsong Huang*, Advanced Optical Materials, 348-353 (2014) High Gain and Low-Driving-Voltage Photodetectors Based on Organolead Triiodide Perovskites Rui Dong, Yanjun Fang, Jungseok Chae, Jun Dai, Zhengguo Xiao, Qingfeng Dong,Yongbo Yuan, Andrea Centrone,Xiao Cheng Zeng , Jinsong Huang*. ,Advanced Materials, 2015

  20. Laser Chemistry: Nanoporous Carbons Derived from Metal-Organic Frameworks as Novel Matrices for Surface-Assisted Laser Desorption/Ionization Mass Spectrometry (Small 15/2016).

    PubMed

    Shih, Yung-Han; Fu, Chien-Ping; Liu, Wan-Ling; Lin, Chia-Her; Huang, Hsi-Ya; Ma, Shengqian

    2016-04-01

    On page 2057, a Lewis acid porous carbon material with tunable hydrophilicity is prepared by temperature controlled pyrolysis of Al based metal-organic frameworks, by C.-H. Lin, H.-Y. Huang, S. Ma, and co-workers. This porous carbon highlights its low heat capacity, and high water uptake, which acts as efficient laser-absorbing matrix/sorbent for detecting trace levels of target compounds. PMID:27076045

  1. Further comparison of theory and experiment for decay of homogeneous turbulence.

    NASA Technical Reports Server (NTRS)

    Deissler, R. G.

    1972-01-01

    An analysis of the decay of homogeneous turbulence from a given initial state is compared with the experiment of Lin and Huang (1970). Comparisons were made for decay of turbulent energy, decay of energy-transfer spectra, decay of three-dimensional turbulent-energy spectra, and decay of higher-order spectral quantities V, R, and S, where these respectively represent functionals of three-, four-, and five-point spectral quantities. Good agreement between theory and experiment is noted.

  2. Terahertz Detection: Extreme Sensitivity of Room-Temperature Photoelectric Effect for Terahertz Detection (Adv. Mater. 1/2016).

    PubMed

    Huang, Zhiming; Zhou, Wei; Tong, Jinchao; Huang, Jingguo; Ouyang, Cheng; Qu, Yue; Wu, Jing; Gao, Yanqing; Chu, Junhao

    2016-01-01

    Terahertz (THz) is the gap between infrared and microwave frequencies. THz detection is still a formidable challenge even though no suitable theory has been built until now, although considerable mechanisms have been proposed. On page 112, Z. Huang and co-workers propose a unique theory to realize an excellent photoelectric effect and experimentally demonstrate its extreme sensitivity to room-temperature THz detection. PMID:26782755

  3. Treatment strategies for combining immunostimulatory oncolytic virus therapeutics with dendritic cell injections.

    PubMed

    Wares, Joanna R; Crivelli, Joseph J; Yun, Chae-Ok; Choi, Il-Kyu; Gevertz, Jana L; Kim, Peter S

    2015-12-01

    Oncolytic viruses (OVs) are used to treat cancer, as they selectively replicate inside of and lyse tumor cells. The efficacy of this process is limited and new OVs are being designed to mediate tumor cell release of cytokines and co-stimulatory molecules, which attract cytotoxic T cells to target tumor cells, thus increasing the tumor-killing effects of OVs. To further promote treatment efficacy, OVs can be combined with other treatments, such as was done by Huang et al., who showed that combining OV injections with dendritic cell (DC) injections was a more effective treatment than either treatment alone. To further investigate this combination, we built a mathematical model consisting of a system of ordinary differential equations and fit the model to the hierarchical data provided from Huang et al. We used the model to determine the effect of varying doses of OV and DC injections and to test alternative treatment strategies. We found that the DC dose given in Huang et al. was near a bifurcation point and that a slightly larger dose could cause complete eradication of the tumor. Further, the model results suggest that it is more effective to treat a tumor with immunostimulatory oncolytic viruses first and then follow-up with a sequence of DCs than to alternate OV and DC injections. This protocol, which was not considered in the experiments of Huang et al., allows the infection to initially thrive before the immune response is enhanced. Taken together, our work shows how the ordering, temporal spacing, and dosage of OV and DC can be chosen to maximize efficacy and to potentially eliminate tumors altogether. PMID:26775859

  4. Technology Transfer/Commercialization Report 2002

    NASA Technical Reports Server (NTRS)

    2002-01-01

    Contents include the following: 1. Technology opportunities and successes in 2002: Hilbert-Huang transform. New sensors via sol-gel-filled fiber optics. Hierarchical segmentation software. 2. Activity in 2002: encouraging researcher involvment. 10th annual new technology reporting award program. Commercial technology development program. 3. Inventorying new technologies: Sensors and detectors. Environmental systems. Information systems. Guidance, navigation, and control. Thermal and cryogenics. Optics. Patenting Goddard technologies. Striking gold with NASA technology transfer.

  5. Davydov Ansatz as an efficient tool for the simulation of nonlinear optical response of molecular aggregates.

    PubMed

    Sun, Ke-Wei; Gelin, Maxim F; Chernyak, Vladimir Y; Zhao, Yang

    2015-06-01

    We have developed a variational approach to the description of four-wave-mixing signals of molecular aggregates, in which the third-order response functions are evaluated in terms of the Davydov Ansätze. Our theory treats both singly and doubly excited excitonic states, handling the contributions due to stimulated emission, ground state bleach, and excited state absorption. As an illustration, we simulate a series of optical two-dimensional spectra of model J-aggregates. Our approach may become suitable for the computation of femtosecond optical four-wave-mixing signals of molecular aggregates with intermediate-to-strong exciton-phonon and exciton-exciton coupling strengths. PMID:26049468

  6. A variational eigenvalue solver on a photonic quantum processor

    PubMed Central

    Peruzzo, Alberto; McClean, Jarrod; Shadbolt, Peter; Yung, Man-Hong; Zhou, Xiao-Qi; Love, Peter J.; Aspuru-Guzik, Alán; O’Brien, Jeremy L.

    2014-01-01

    Quantum computers promise to efficiently solve important problems that are intractable on a conventional computer. For quantum systems, where the physical dimension grows exponentially, finding the eigenvalues of certain operators is one such intractable problem and remains a fundamental challenge. The quantum phase estimation algorithm efficiently finds the eigenvalue of a given eigenvector but requires fully coherent evolution. Here we present an alternative approach that greatly reduces the requirements for coherent evolution and combine this method with a new approach to state preparation based on ansätze and classical optimization. We implement the algorithm by combining a highly reconfigurable photonic quantum processor with a conventional computer. We experimentally demonstrate the feasibility of this approach with an example from quantum chemistry—calculating the ground-state molecular energy for He–H+. The proposed approach drastically reduces the coherence time requirements, enhancing the potential of quantum resources available today and in the near future. PMID:25055053

  7. On detecting interactions in the dark sector with H(z) data

    NASA Astrophysics Data System (ADS)

    Ferreira, Pedro C.; Pavón, Diego; Carvalho, Joel C.

    2013-10-01

    An interesting approach to the cosmological coincidence problem is to allow dark matter and dark energy to interact with each other also nongravitationally. We consider two general Ansätze for such an interaction and appraise their ability to address the coincidence problem. We determine the average accuracy required on the cosmic expansion rate data to distinguish interacting cosmological models from the conventional ΛCDM scenario. We find that among the planned surveys the Wide Field Infrared Survey Telescope has the best chance to detect an interaction, though at a low significance level. To unambiguously determine the existence of an interaction one must, therefore, combine the said expansion data with other probes.

  8. Products of Independent Elliptic Random Matrices

    NASA Astrophysics Data System (ADS)

    O'Rourke, Sean; Renfrew, David; Soshnikov, Alexander; Vu, Van

    2015-07-01

    For fixed , we study the product of independent elliptic random matrices as tends to infinity. Our main result shows that the empirical spectral distribution of the product converges, with probability , to the -th power of the circular law, regardless of the joint distribution of the mirror entries in each matrix. This leads to a new kind of universality phenomenon: the limit law for the product of independent random matrices is independent of the limit laws for the individual matrices themselves. Our result also generalizes earlier results of Götze-Tikhomirov (On the asymptotic spectrum of products of independent random matrices, available at http://arxiv.org/abs/1012.2710) and O'Rourke-Soshnikov (J Probab 16(81):2219-2245, 2011) concerning the product of independent iid random matrices.

  9. Polaron dynamics with a multitude of Davydov D2 trial states.

    PubMed

    Zhou, Nengji; Huang, Zhongkai; Zhu, Jiangfeng; Chernyak, Vladimir; Zhao, Yang

    2015-07-01

    We propose an extension to the Davydov D2 Ansatz in the dynamics study of the Holstein molecular crystal model with diagonal and off-diagonal exciton-phonon coupling using the Dirac-Frenkel time-dependent variational principle. The new trial state by the name of the "multi-D2 Ansatz" is a linear combination of Davydov D2 trial states, and its validity is carefully examined by quantifying how faithfully it follows the Schrödinger equation. Considerable improvements in accuracy have been demonstrated in comparison with the usual Davydov trial states, i.e., the single D1 and D2 Ansätze. With an increase in the number of the Davydov D2 trial states in the multi-D2 Ansatz, deviation from the exact Schrödinger dynamics is gradually diminished, leading to a numerically exact solution to the Schrödinger equation. PMID:26156471

  10. D mesons in a magnetic field

    NASA Astrophysics Data System (ADS)

    Gubler, Philipp; Hattori, Koichi; Lee, Su Houng; Oka, Makoto; Ozaki, Sho; Suzuki, Kei

    2016-03-01

    We investigate the mass spectra of open heavy flavor mesons in an external constant magnetic field within QCD sum rules. Spectral Ansätze on the phenomenological side are proposed in order to properly take into account mixing effects between the pseudoscalar and vector channels, and the Landau levels of charged mesons. The operator product expansion is implemented up to dimension-5 operators. As a result, we find for neutral D mesons a significant positive mass shift that goes beyond simple mixing effects. In contrast, charged D mesons are further subject to Landau level effects, which together with the mixing effects almost completely saturate the mass shifts obtained in our sum rule analysis.

  11. Gauge covariance and the fermion-photon vertex in three- and four-dimensional, massless quantum electrodynamics

    SciTech Connect

    Burden, C.J. ); Roberts, C.D. )

    1993-06-15

    In the quenched approximation, the gauge covariance properties of three vertex [ital Ansa]$[ital iuml]---[ital tze] in the Schwinger-Dyson equation for the fermion self-energy are analyzed in three- and four-dimensional quantum electrodynamics. Based on the Cornwall-Jackiw-Tomboulis effective action, it is inferred that the spectral representation used for the vertex in the gauge technique cannot support dynamical chiral symmetry breaking. A criterion for establishing whether a given [ital Ansatz] can confer gauge covariance upon the Schwinger-Dyson equation is presented and the Curtis and Pennington [ital Ansatz] is shown to satisfy this constraint. We obtain an analytic solution of the Schwinger-Dyson equation for quenched, massless three-dimensional quantum electrodynamics for arbitrary values of the gauge parameter in the absence of dynamical chiral symmetry breaking.

  12. Approach to exact solutions of cosmological perturbations: Tachyon field inflation

    NASA Astrophysics Data System (ADS)

    Herrera, Ramón; Pérez, Roberto G.

    2016-03-01

    An inflationary universe scenario in the context of a tachyon field is studied. This study is carried out using an ansatz for the effective potential of cosmological perturbations U (η ). We describe in great detail the analytical solutions of the scalar and tensor perturbations for two different Ansätze for the effective potential of cosmological perturbations: Easther's model and an effective potential similar to power-law inflation. Also, we find from the background equations that the effective tachyonic potentials V (φ ) in both models satisfy the properties of a tachyonic potential. We consider the recent data from the Planck to constrain the parameters in our effective potential generating the cosmological perturbations.

  13. Analyse unterschiedlicher Modellierungsvarianten des "Direct Power Injection" Verfahrens für die EMV Charakterisierung integrierter Schaltungen

    NASA Astrophysics Data System (ADS)

    Stürmer, U.; Ritzmann, S.; Jovic, O.; Wilkening, W.

    2009-05-01

    Dieser Beitrag analysiert zwei Ansätze zur Modellierung eines Teststandes zur Charakterisierung von integrierten Schaltungen mittels Direct Power Injection (DPI) auf einem Wafer. Die erste Variante ist zur Analyse bereits vorliegender integrierter Schaltungen nutzbar. Sie benötigt gemessene S-Parameterdaten, mit denen die an einem realen Messobjekt anliegenden Störspannungen frequenzabhängig bestimmt werden können. Die zweite Variante ist bereits anwendbar, bevor Silizium gefertigt worden ist. Sie modelliert einen Netzwerkanalysatorkanal der aus einer Signalquelle, einem Leistungsmesser und einem Verstärker mit nachgeschaltetem Richtkoppler und Entkoppelnetzwerken besteht. Zunächst werden die oben genannten verschiedenen Varianten der DPI-Streckenmodellierung dargestellt. Sie werden miteinander und anhand von Messdaten einer einfachen Teststruktur verglichen. Die Teststruktur besteht aus einem MOS-Transistor mit Arbeitswiderstand. Der Beitrag diskutiert Vor- und Nachteile der Varianten einschließlich Modellierungsaufwand und Simulationsgeschwindigkeit.

  14. Fische und Fischerzeugnisse

    NASA Astrophysics Data System (ADS)

    Oehlenschläger, Jörg

    Fische und Fischerzeugnisse lassen sich gemäß den "Leitsätzen für Fische, Krebs- und Weichtiere und Erzeugnisse daraus" des Deutschen Lebensmittelbuches einteilen. Tiefgefrorene Fische werden von den "Leitsätzen für tiefgefrorene Fische, Krebs- und Weichtiere und Erzeugnisse daraus" und Salate mit Fleisch von Fischen, Krebs- und/oder Weichtieren durch Abschnitt II.B. der "Leitsätze für Feinkostsalate" abgedeckt. Zu nennen sind: Frischfische, Getrocknete Fische, Räucherfische, Gesalzene Fische, Erzeugnisse aus gesalzenen Fischen, Anchosen, Marinaden, Bratfischwaren, Kochfischwaren, Fischerzeugnisse in Gelee, Pasteurisierte Fischerzeugnisse, Fischdauerkonserven, Erzeugnisse aus Surimi, Krebstiere und Krebstiererzeugnisse, Weichtiere und Weichtiererzeugnisse und tiefgekühlte Fischereierzeugnisse.

  15. Semantic Desktop

    NASA Astrophysics Data System (ADS)

    Sauermann, Leo; Kiesel, Malte; Schumacher, Kinga; Bernardi, Ansgar

    In diesem Beitrag wird gezeigt, wie der Arbeitsplatz der Zukunft aussehen könnte und wo das Semantic Web neue Möglichkeiten eröffnet. Dazu werden Ansätze aus dem Bereich Semantic Web, Knowledge Representation, Desktop-Anwendungen und Visualisierung vorgestellt, die es uns ermöglichen, die bestehenden Daten eines Benutzers neu zu interpretieren und zu verwenden. Dabei bringt die Kombination von Semantic Web und Desktop Computern besondere Vorteile - ein Paradigma, das unter dem Titel Semantic Desktop bekannt ist. Die beschriebenen Möglichkeiten der Applikationsintegration sind aber nicht auf den Desktop beschränkt, sondern können genauso in Web-Anwendungen Verwendung finden.

  16. Atomic Basic Blocks

    NASA Astrophysics Data System (ADS)

    Scheler, Fabian; Mitzlaff, Martin; Schröder-Preikschat, Wolfgang

    Die Entscheidung, einen zeit- bzw. ereignisgesteuerten Ansatz für ein Echtzeitsystem zu verwenden, ist schwierig und sehr weitreichend. Weitreichend vor allem deshalb, weil diese beiden Ansätze mit äußerst unterschiedlichen Kontrollflussabstraktionen verknüpft sind, die eine spätere Migration zum anderen Paradigma sehr schwer oder gar unmöglich machen. Wir schlagen daher die Verwendung einer Zwischendarstellung vor, die unabhängig von der jeweils verwendeten Kontrollflussabstraktion ist. Für diesen Zweck verwenden wir auf Basisblöcken basierende Atomic Basic Blocks (ABB) und bauen darauf ein Werkzeug, den Real-Time Systems Compiler (RTSC) auf, der die Migration zwischen zeit- und ereignisgesteuerten Systemen unterstützt.

  17. Privacy im Social Semantic Web

    NASA Astrophysics Data System (ADS)

    Nagenborg, Michael

    Der Schwerpunkt dieses Beitrages liegt auf dem Design von Infrastrukturen, welche es ermöglichen sollen, private Daten kontrolliert preiszugeben und auszutauschen. Zunächst wird daran erinnert, dass rechtliche und technische Maßnahmen zum Datenschutz stets auch dazu dienen, den Austausch von Daten zu ermöglichen. Die grundlegende Herausforderung besteht darin, der sozialen und politischen Bedeutung des Privaten Rechnung zu tragen. Privatheit wird aus der Perspektive der Informationsethik dabei als ein normatives, handlungsleitendes Konzept verstanden. Als Maßstab für die Gestaltung der entsprechenden Infrastrukturen wird auf Helen Nissenbaums Konzept der privacy as contextual integrity" zurückgegriffen, um u. a. die Ansätze der end-to-end information accountability" [38] und des Privacy Identity Management for Europe"- Projektes zu diskutieren.

  18. Invited Commentary: Multigenerational Social Determinants of Health—Opportunities and Challenges.

    PubMed

    Cohen, Alison K; Lê-Scherban, Félice

    2015-10-01

    An emerging area of social epidemiology examines the relationship between grandparental education and grandchild health. In an accompanying article, Huang et al. (Am J Epidemiol. 2015;182(7):568-578) join the small but growing body of research on this topic. It is useful to contextualize Huang et al.'s work within the much larger body of research examining relationships between education and health within a single generation or across 2 generations. These investigators have generally concluded that higher educational attainment is robustly associated with better health. There are many potential mechanisms through which education and other social exposures may affect health outcomes in a single generation or across generations, and estimating direct and indirect effects can be helpful for assessing specific mechanisms. Researchers conducting multigenerational analyses are faced with several challenges, including limited availability of data for some measures (e.g., educational attainment, and sometimes for 1 grandparent only), limited age ranges of participants, disparate social and political contexts in which study participants of different generations have lived, and patterns of social class reproduction. We encourage future researchers to weave together the careful analytical considerations illustrated by Huang et al. with a rich understanding of the social context for each of the generations studied to help overcome these challenges and advance our understanding of multigenerational social determinants of health. PMID:26283087

  19. Traditional Chinese Medicine and herbal hepatotoxicity: a tabular compilation of reported cases.

    PubMed

    Teschke, Rolf; Zhang, Li; Long, Hongzhu; Schwarzenboeck, Alexander; Schmidt-Taenzer, Wolfgang; Genthner, Alexander; Wolff, Albrecht; Frenzel, Christian; Schulze, Johannes; Eickhoff, Axel

    2015-01-01

    Traditional Chinese Medicine (TCM) with its focus on herbal use became popular worldwide. Treatment was perceived as safe, with neglect of rare adverse reactions including liver injury. To compile worldwide cases of liver injury by herbal TCM, we undertook a selective literature search in the PubMed database and searched for the items Traditional Chinese Medicine, TCM, Traditional Asian Medicine, and Traditional Oriental Medicine, also combined with the terms herbal hepatotoxicity or herb induced liver injury. The search focused primarily on English-language case reports, case series, and clinical reviews. We identified reported hepatotoxicity cases in 77 relevant publications with 57 different herbs and herbal mixtures of TCM, which were further analyzed for causality by the Council for International Organizations of Medical Sciences (CIOMS) scale, positive reexposure test results, or both. Causality was established for 28/57 different herbs or herbal mixtures, Bai Xian Pi, Bo He, Ci Wu Jia, Chuan Lian Zi, Da Huang, Gan Cao, Ge Gen, Ho Shou Wu, Huang Qin, Hwang Geun Cho, Ji Gu Cao, Ji Xue Cao, Jin Bu Huan, Jue Ming Zi, Jiguja, Kudzu, Ling Yang Qing Fei Keli, Lu Cha, Rhen Shen, Ma Huang, Shou Wu Pian, Shan Chi, Shen Min, Syo Saiko To, Xiao Chai Hu Tang, Yin Chen Hao, Zexie, and Zhen Chu Cao. In conclusion, this compilation of liver injury cases establishes causality for 28/57 different TCM herbs and herbal mixtures, aiding diagnosis for physicians who care for patients with liver disease possibly related to herbal TCM. PMID:25536637

  20. EPR of Barium Titanate to 36 kbar between 0 and - 40 degrees Celsius

    NASA Astrophysics Data System (ADS)

    Decker, D. L.

    1998-04-01

    A few years ago we made EPR measurements of barium titanate in a specially designed pressure apparatus at temperatures below ambient. The description of the apparatus has been published(1) and the results of the experiment are reported in Huang's dissertation(2). These measurements were taken near the ferroelectric-paraelectric phase line in the ferroelectric phase. Recently I have been refining the analysis of the data to get the maximum amount of information available on the response of barium titanate to high pressures as one approaches the tricritical point. We have found that the EPR signal for the respective transitions of the 5/2 spin state of Fe, which is a very dilute impurity in the material, is not purely Lorentzian but can be very accurately represented by two slightly separated Lorentzian lines, as if there were two types of iron sites both with tetragonal or nearly tetragonal symmetry. We will discuss the method of analysis and show some interesting results of the measurement as a function of the relative distance from the phase transition line. 1. Ke Huang, D.L. Decker, H.M. Nelson, and J.D. Barnett, Rev. of Sci. Instr. 68, 3877 (1997). 2. Ke Huang, Dissertation, Brigham Young University, Provo, UT (1995).

  1. Treatment of acute bronchiolitis with Chinese herbs.

    PubMed Central

    Kong, X T; Fang, H T; Jiang, G Q; Zhai, S Z; O'Connell, D L; Brewster, D R

    1993-01-01

    In a randomised single blind trial the Chinese herbs Shuang Huang Lian were evaluated for the treatment of acute bronchiolitis. Children with acute bronchiolitis and serological evidence of recent respiratory syncytial virus infection were studied in a tertiary hospital in Harbin, China. The 96 children were randomised into three treatment groups: herbs, herbs with antibiotics, and antibiotics alone. The herbs were prepared by the medical school pharmacy and administered daily by intravenous infusion for seven days. The main outcomes, assessed blindly, were symptomatic improvement in cough, fever, wheezing, chest signs, and duration of stay in hospital. The mean duration of symptoms from the start of treatment was 6.2 (confidence interval 5.6 to 6.9) days in the two groups treated with herbs compared with 8.6 (confidence interval 7.5 to 9.8) days in the group treated with antibiotics alone. The mean reductions in duration of clinical manifestations for treatment with antibiotics alone compared with herbs were: from 3.1 to 1.5 days for fever, 9.1 to 6.1 days for cough, 6.5 to 4.1 days for wheezing, and 7.2 to 4.9 days for chest crackles. No adverse effect of Shuang Huang Lian herbal treatment was detected. In conclusion, this study confirms Chinese experience with Shuang Huang Lian that it is safe and effective, and warrants further study. PMID:8503668

  2. Nonoscillation and oscillation of second order half-linear differential equations

    NASA Astrophysics Data System (ADS)

    Kong, Qingkai

    2007-08-01

    We study the oscillation problems for the second order half-linear differential equation [p(t)[Phi](x')]'+q(t)[Phi](x)=0, where [Phi](u)=ur-1u with r>0, 1/p and q are locally integrable on ; p>0, q[greater-or-equal, slanted]0 a.e. on , and . We establish new criteria for this equation to be nonoscillatory and oscillatory, respectively. When p[identical to]1, our results are complete extensions of work by Huang [C. Huang, Oscillation and nonoscillation for second order linear differential equations, J. Math. Anal. Appl. 210 (1997) 712-723] and by Wong [J.S.W. Wong, Remarks on a paper of C. Huang, J. Math. Anal. Appl. 291 (2004) 180-188] on linear equations to the half-linear case for all r>0. These results provide corrections to the wrongly established results in [J. Jiang, Oscillation and nonoscillation for second order quasilinear differential equations, Math. Sci. Res. Hot-Line 4 (6) (2000) 39-47] on nonoscillation when 01. The approach in this paper can also be used to fully extend Elbert's criteria on linear equations to half-linear equations which will cover and improve a partial extension by Yang [X. Yang, Oscillation/nonoscillation criteria for quasilinear differential equations, J. Math. Anal. Appl. 298 (2004) 363-373].

  3. Surface light-scattering at the air-liquid interface: from newtonian to viscoelastic polymer solutions.

    PubMed

    Muñoz, Mercedes G; Encinar, Mario; Bonales, Laura J; Ortega, Francisco; Monroy, Francisco; Rubio, Ramón G

    2005-03-17

    The dynamics of the liquid-air interface of aqueous solutions of a tensioactive triblock copolymer (Pluronic F-68) has been studied using surface quasielastic light scattering over a broad range of concentrations and temperatures. Ancillary surface tension and bulk rheometry data have been obtained for the same system. The results show that the classical theoretical spectrum for monolayers on a Newtonian fluid can be applied only for concentrations below 4.10(-2) mM. For concentrations above c = 14 mM a clear peak centered at zero frequency appears in the spectrum. This feature is incompatible with the classical theoretical spectrum. The SQELS spectra have been described in terms of the theory of Wang and Huang [Wang, C. H.; Huang, Q. R. J. Chem. Phys. 1997, 107, 5898] considering that the loss modulus of the concentrated solutions shows the existence of two relaxation modes even at low frequencies. The theory is able to explain the existence of a peak centered at zero frequency in the spectra, and the theoretical spectra point out the existence of an elastic peak together with the capillary one. There is a reasonable agreement between the relaxation times and the product Gtau obtained from the fits of the SQELS spectra to the theory of Wang and Huang and those obtained from bulk rheology. PMID:16851550

  4. The Core Pattern Analysis on Chinese Herbal Medicine for Sjögren's syndrome: A Nationwide Population-Based Study.

    PubMed

    Chang, Ching-Mao; Chu, Hsueh-Ting; Wei, Yau-Huei; Chen, Fang-Pey; Wang, Shengwen; Wu, Po-Chang; Yen, Hung-Rong; Chen, Tzeng-Ji; Chang, Hen-Hong

    2015-01-01

    This large-scale survey aimed to evaluate frequencies and patterns of Chinese herbal medicine (CHM) used for Sjögren's syndrome (SS) in Taiwan by analyzing the National Health Insurance Research Database (NHIRD) for cases in which CHM was used as an alternative therapy to Western medicine for improving patients' discomforts. We analyzed cases of SS principal diagnosis (ICD-9:710.2) with a catastrophic illness certificate (CIC) in traditional Chinese medicine (TCM) outpatient clinics from three cohorts of the Longitudinal Health Insurance Database (LHID) in the NHIRD between 2002 and 2011. CHM prescription patterns for SS were evaluated from claimed visitation files and corresponding prescription files. There were 15,914 SS patients with CIC (SS/CIC), and we found only 130 SS/CIC cases visiting TCM clinics in LHID2000, 133 in LHID2005, and 126 in LHID2010. After removing duplicate data, 366 SS/CIC and 4,867 visits were analyzed. The 50-59 year age group showed the highest ratio (29.51%) in both women and men. "Qi-Ju-Di-Huang-Wan" and "Xuan-Shen" (Scrophularia ningpoensis Hemsl.) was the most commonly used formula and single herb, respectively. "Qi-Ju-Di-Huang-Wan, Gan-Lu-Yin, Xuan-Shen, Mai-Men-Dong (Ophiopogon japonicus (L. f.) Ker-Gawl.), and Sheng-Di-Huang (raw Rehmannia glutinosa Libosch)" were the core pattern prescriptions in treating SS/CIC. PMID:25923413

  5. Nonperiodic metallic gratings transparent for broadband terahertz waves

    NASA Astrophysics Data System (ADS)

    Fan, Ren-Hao; Ren, Xiao-Ping; Peng, Ru-Wen; Huang, Xian-Rong; Wang, Mu

    Recently, we demonstrate both theoretically and experimentally that nonperiodic metallic gratings can become transparent for broadband terahertz waves. Quasiperiodic and disordered metallic gratings effectively weaken and even eliminate Wood's anomalies, which are the diffraction-related characters of periodic gratings. Consequently, both the transparence bandwidth and transmission efficiency are significantly increased due to the structural aperiodicity. Furthermore, we show that for a specific light source, for example, a line source, a corresponding nonperiodic transparent grating can be also designed. We expect that our findings can be applied for transparent conducting panels, perfect white-beam polarizers, antireflective conducting solar cells, and beyond. References: X. P. Ren, R. H. Fan, R. W. Peng, X. R. Huang, D. H. Xu, Y. Zhou, and Mu Wang, Physical Review B, 91, 045111 (2015); R. H. Fan, R. W. Peng, X. R. Huang, J. Li, Y. Liu, Q. Hu, Mu. Wang, and X. Zhang, Advanced Materials, 24, 1980 (2012); and X. R. Huang, R. W. Peng, and R. H. Fan. Physical Review Letters, 105, 243901 (2010).

  6. Pyrazole and Pyrazolate as Ligands in the Synthesis and Stabilization of New Palladium(II) and (III) Compounds.

    PubMed

    Estevan, Francisco; Hirva, Pipsa; Ofori, Albert; Sanaú, Mercedes; Špec, Tanja; Úbeda, MaAngeles

    2016-03-01

    The versatility of pyrazole/pyrazolate as ligands has allowed the synthesis and the structural characterization of four different types of new orthometalated palladium compounds, for which DFT calculations have been performed in order to investigate their relative stabilities. [Pd2{μ-(C6H4)PPh2}2{μ-(R,R'2pz)}2] (R = R' = H, 2a; R = Br, R' = H, 2b; R = CH3, R' = H, 2c; R = H, R' = CH3, 2d; R = Br, R' = CH3, 2e) compounds with exo-bidentate pyrazolatos are the first paddlewheel dinuclear palladium(II) compounds with pyrazolato bridging ligands described and characterized in the literature. In the process of the synthesis of 2a, a new tetranuclear intermediate compound, [Pd4{μ-(C6H4)PPh2}4(μ-pz)2(μ-OH)2] (3a), has been isolated and structurally characterized. Compounds of the general formula [Pd2{μ-(C6H4)PPh2}2Br2(R,R'2pzH)2] (R = R' = H, 4a; R = Br; R' = H, 4b; R = CH3; R' = H, 4c; R = H; R' = CH3, 4d; R = Br; R' = CH3, 4e) with pyrazoles as monodentate ligands have also been obtained, in which, according to the QTAIM analysis, additional Br···HNpz weak interactions stabilize their structure. The tetranuclear Pd2Ag2 compounds, [Pd2{μ-(C6H4)PPh2}2{μ-(R,R'2pz-Ag-R,R'2pz)}2] (R = R' = H, 5a; R = Br; R' = H, 5b; R = CH3, R' = H, 5c), showed a distorted tetrahedron disposition of the metal atoms. The QTAIM analysis revealed an enhanced stability because of additional metal-metal interactions. New palladium(III) compounds, [Pd2{μ-(C6H4)PPh2}2{μ-(R,R'2pz)}2Cl2] (R = R' = H, 6a; R = Br, R' = H, 6b) were also synthesized by oxidation of compounds 2 with PhICl2. DFT calculations highlighted their greater stability compared to that of similar compounds with N,N-donor ligands, such as formamidinatos and triazenidos. PMID:26914982

  7. Fabrication and properties of silicon carbide nanowires

    NASA Astrophysics Data System (ADS)

    Shim, Hyun Woo

    2008-12-01

    Silicon carbide (SiC), with excellent electrical, thermal, and mechanical properties, is a promising material candidate for future devices such as high-temperature electronics and super-strong lightweight structures. Combined with superior intrinsic properties, the nanomaterials of SiC show further advantages thanks to nanoscale effects. This thesis reports the growth mechanism, the self-integration, and the friction of SiC nanowires. The study involves nanowires fabrication using thermal evaporation, structure characterization using electron microscopy, friction measurement, and theoretical modeling. The study on nanowire growth mechanism requires understanding of the surfaces and interfaces of nanowire crystal. The catalyzed growth of SiC nanowires involves interfaces between source vapor, catalytic liquid, and nanowire solid. Our experimental observation includes the periodical twinning in a faceted SiC nanowire and three stage structure transitions during the growth. The proposed theoretical model shows that such phenomenon is the result of surface energy minimization process during the catalytic growth. Surface interactions also exist between nanowires, leading to their self-integration. Our parametric growth study reveals novel self-integration of SiC-SiO 2 core-shell nanowires as a result of SiO2 joining. Attraction between nanowires through van der Waals force and enhanced SiO2 diffusion at high temperature transform individual nanowires to the integrated nanojunctions, nanocables, and finally nanowebs. We also show that such joining process becomes effective either during growth or by annealing. The solid friction is a result of the interaction between two solid surfaces, and it depends on the adhesion and the deformation of two contacting solids among other factors. Having strong adhesion as shown from gecko foot-hairs, nanostructured materials should also have strong friction; this study is the first to investigate friction of nanostructures under (compressive) normal loads. Here, we show that the friction forces of SiC nanowires films is 5--12 that of macroscopic solids. For nanowires films, the maximum static frictional force varies linearly with, but is not proportional to, normal load; it increases linearly with interface area; and it is independent of loading speed. To summarize, the combined experimental and theoretical studies in this thesis demonstrated unique structures and surface properties of SiC nanowires, including: (1) Periodical twinning, surface faceting, and structure transition, [Shim & Huang, Appl. Phy. Lett. 90, 083106] (2) Twinning growth mechanism, [Shim, Zhang & Huang, J. Appl. Phys., submitted; Zhang, Shim, & Huang, Appl. Phys. Lett. 92, 261908] (3) Self-integration (nanowebs formation) during growth, [Shim & Huang, Nanotechnology 18, 335607] (4) Thermal stability and self-integration by annealing, [Shim, Kuppers & Huang, J. Nanosci. Nanotech. 8, 3999] and (5) Strong friction of nanowires film. [Shim, Kuppers & Huang, NATURE Nanotech., submitted] The collection of these results enhances the understanding of SiC nanowires growth, the better control of their microstructure and integration, and the application of ceramic nanowires as friction material at high temperature.

  8. Long transient phenomenon in nonlinear structural vibration

    NASA Astrophysics Data System (ADS)

    Frank Pai, P.

    2009-03-01

    The long transient phenomenon in nonlinear structural vibrations is examined in detail by using a signal decomposition and processing method based on the empirical mode decomposition, Hilbert-Huang transform (HHT), and nonlinear dynamic characteristics derived from perturbation analysis. A sliding-window fitting (SWF) technique is derived to show the physical implication of Hilbert-Huang transform and other time-frequency decomposition methods. The SWF uses windowed regular harmonics and function orthogonality to simultaneously extract time-localized regular and/or distorted harmonics. Because of the use of pre-determined basis functions, function orthogonality, and windowed curve fitting for component extraction, it cannot extract accurate time-varying frequencies and amplitudes of harmonics distorted by nonlinearities. On the other hand, the HHT uses the apparent time scales revealed by the signal's local maxima and minima to sequentially sift distorted harmonics of different time scales, starting from high-frequency to low-frequency ones. Because Hilbert-Huang transform does not use predetermined basis functions and function orthogonality for component extraction, it provides more accurate signal decomposition and instant amplitudes and frequencies of extracted distorted harmonics. Numerical results show that the proposed HHT-based signal decomposition and processing method can accurately decompose nonlinear nonstationary signals and extract accurate intrawave amplitude and phase modulations, distorted harmonic response under a single-frequency harmonic excitation, and different types and orders of nonlinearities. Using this signal processing method, the long transient phenomenon in nonlinear vibrations is found to be caused by nonlinearities, coupling of transient and forced vibrations, and/or modal coupling of multiple modes.

  9. Commentary on "integrative genomic analyses reveal an androgen-driven somatic alteration landscape in early-onset prostate cancer." Weischenfeldt J, Simon R, Feuerbach L, Schlangen K, Weichenhan D, Minner S, Wuttig D, Warnatz HJ, Stehr H, Rausch T, Jäger N, Gu L, Bogatyrova O, Stütz AM, Claus R, Eils J, Eils R, Gerhäuser C, Huang PH, Hutter B, Kabbe R, Lawerenz C, Radomski S, Bartholomae CC, Fälth M, Gade S, Schmidt M, Amschler N, Haß T, Galal R, Gjoni J, Kuner R, Baer C, Masser S, von Kalle C, Zichner T, Benes V, Raeder B, Mader M, Amstislavskiy V, Avci M, Lehrach H, Parkhomchuk D, Sultan M, Burkhardt L, Graefen M, Huland H, Kluth M, Krohn A, Sirma H, Stumm L, Steurer S, Grupp K, Sültmann H, Sauter G, Plass C, Brors B, Yaspo ML, Korbel JO, Schlomm T, Genome Biology Unit, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany.: Cancer Cell 2013;23(2):159-70.

    PubMed

    Olumi, Aria F

    2014-02-01

    Early-onset prostate cancer (EO-PCA) represents the earliest clinical manifestation of prostate cancer. To compare the genomic alteration landscapes of EO-PCA with "classical" (elderly-onset) PCA, we performed deep sequencing-based genomics analyses in 11 tumors diagnosed at young age, and pursued comparative assessments with seven elderly-onset PCA genomes. Remarkable age-related differences in structural rearrangement (SR) formation became evident, suggesting distinct disease pathomechanisms. Whereas EO-PCAs harbored a prevalence of balanced SRs, with a specific abundance of androgen-regulated ETS gene fusions including TMPRSS2:ERG, elderly-onset PCAs displayed primarily non-androgen-associated SRs. Data from a validation cohort of>10,000 patients showed age-dependent androgen receptor levels and a prevalence of SRs affecting androgen-regulated genes, further substantiating the activity of a characteristic "androgen-type" pathomechanism in EO-PCA. PMID:24445294

  10. Transient signal detection using the empirical mode decomposition

    NASA Astrophysics Data System (ADS)

    Larsen, Michael L.; Ridgway, Jeffrey; Waldman, Cye H.; Gabbay, Michael; Buntzen, Rodney R.; Battista, Brad

    2004-10-01

    In this paper, we report on efforts to develop signal processing methods appropriate for the detection of man-made electromagnetic signals in the nonlinear and nonstationary underwater electromagnetic noise environment of the littoral. Using recent advances in time series analysis methods [Huang et al., 1998], we present new techniques for detection and compare their effectiveness with conventional signal processing methods, using experimental data from recent field experiments. These techniques are based on an empirical mode decomposition which is used to isolate signals to be detected from noise without a priori assumptions. The decomposition generates a physically motivated basis for the data.

  11. Research frontiers in drought-induced tree mortality: Crossing scales and disciplines

    DOE PAGESBeta

    Hartmann, Henrik; Adams, Henry D.; Anderegg, William R. L.; Jansen, Steven; Zeppel, Melanie J. B.

    2015-01-12

    Sudden and widespread forest die-back and die-off (e.g., Huang & Anderegg, 2012) and increased mortality rates (e.g., Peng et al., 2011) in many forest ecosystems across the globe have been linked to drought and elevated temperatures (Allen et al., 2010, Fig. 1). Furthermore, these observations have caused a focus on the physiological mechanisms of drought-induced tree mortality (e.g. McDowell et al., 2008) and many studies, both observational and manipulative, have been carried out to explain tree death during drought from a physiological perspective.

  12. A new drought tipping point for conifer mortality

    NASA Astrophysics Data System (ADS)

    Kolb, Thomas E.

    2015-03-01

    (Huang et al 2015 Environ. Res. Lett. 10 024011) present a method for predicting mortality of ponderosa pine (Pinus ponderosa) and pinyon pine (Pinus edulis) in the Southwestern US during severe drought based on the relationship between the standardized precipitation-evapotranspiration index (SPEI) and annual tree ring growth. Ring growth was zero when SPEI for September to July was -1.64. The threshold SPEI of -1.64 was successful in distinguishing areas with high tree mortality during recent severe drought from areas with low mortality, and is proposed to be a tipping point of drought severity leading to tree mortality. Below, I discuss this work in more detail.

  13. Empirical mode decomposition for analyzing acoustical signals

    NASA Technical Reports Server (NTRS)

    Huang, Norden E. (Inventor)

    2005-01-01

    The present invention discloses a computer implemented signal analysis method through the Hilbert-Huang Transformation (HHT) for analyzing acoustical signals, which are assumed to be nonlinear and nonstationary. The Empirical Decomposition Method (EMD) and the Hilbert Spectral Analysis (HSA) are used to obtain the HHT. Essentially, the acoustical signal will be decomposed into the Intrinsic Mode Function Components (IMFs). Once the invention decomposes the acoustic signal into its constituting components, all operations such as analyzing, identifying, and removing unwanted signals can be performed on these components. Upon transforming the IMFs into Hilbert spectrum, the acoustical signal may be compared with other acoustical signals.

  14. Traditional Chinese Medicine Induced Liver Injury

    PubMed Central

    2014-01-01

    Traditional Chinese Medicine (TCM) is popular around the world and encompasses many different practices with particular emphasis on herbal TCM. Using the PubMed database, a literature search was undertaken to assess the extent herbal TCM products exert rare hepatotoxicity. Analysis of reported cases revealed numerous specified herbal TCM products with potential hepatotoxicity. Among these were An Shu Ling, Bai Fang, Bai Xian Pi, Ban Tu Wan, Bo He, Bo Ye Qing Niu Dan, Bofu Tsu Sho San, Boh Gol Zhee, Cang Er Zi, Chai Hu, Chaso, Chi R Yun, Chuan Lian Zi, Ci Wu Jia, Da Chai Hu Tang, Da Huang, Du Huo, Gan Cao, Ge Gen, Ho Shou Wu, Hu Bohe You, Hu Zhang, Huang Qin, Huang Yao Zi, Hwang Geun Cho, Ji Gu Cao, Ji Ji, Ji Xue Cao, Jiguja, Jin Bu Huan, Jue Ming Zi, Kamishoyosan, Kudzu, Lei Gong Teng, Long Dan Xie Gan Tang, Lu Cha, Ma Huang, Mao Guo Tian Jie Cai, Onshido, Polygonum multiflorum, Qian Li Guang, Ren Shen, Sairei To, Shan Chi, Shen Min, Shi Can, Shi Liu Pi, Shou Wu Pian, Tian Hua Fen, White flood, Wu Bei Zi, Xi Shu, Xiao Chai Hu Tang, Yin Chen Hao, Zexie, Zhen Chu Cao, and various unclassified Chinese herbal mixtures. Causality was firmly established for a number of herbal TCM products by a positive reexposure test result, the liver specific scale of CIOMS (Council for International Organizations of Medical Sciences), or both. Otherwise, the quality of case data was mixed, especially regarding analysis of the herb ingredients because of adulteration with synthetic drugs, contamination with heavy metals, and misidentification. In addition, non-herbal TCM elements derived from Agaricus blazei, Agkistrodon, Antelope, Bombyx, Carp, Fish gallbladder, Phellinus, Scolopendra, Scorpio, and Zaocys are also known or potential hepatotoxins. For some patients, the clinical course was severe, with risks for acute liver failure, liver transplantation requirement, and lethality. In conclusion, the use of few herbal TCM products may rarely be associated with hepatotoxicity in some susceptible individuals, necessitating a stringent pretreatment evaluation of the risk/benefit ratio, based on results of multicenter, randomized, double-blind, placebo-controlled clinical trials. PMID:26357619

  15. Rigorous Approach to the Problem of Ultraviolet Divergencies in Dilute Bose Gases

    NASA Astrophysics Data System (ADS)

    Olshanii, Maxim; Pricoupenko, Ludovic

    2002-01-01

    In this Letter we consider a system of N pairwise finite-range interacting atoms and prove rigorously that in the zero-range interaction limit all the eigenstates and eigenenergies of the Hamiltonian converge to those corresponding to N atoms interacting via the Fermi-Huang regularized pseudopotential. Next, we show that the latter eigensystem (if treated exactly) is invariant under a nontrivial transformation of the interaction potential. Finally, we realize that most of the approximate schemes of many-body physics do not exhibit this invariance: We use this property to resolve all inconsistencies of the Hartree-Fock-Bogoliubov variational formalism known thus far.

  16. Nonexistence of the solitary-wave solutions of the Sakuma-Nishiguchi equation

    NASA Astrophysics Data System (ADS)

    Lou, Sen-Yue

    1992-10-01

    Making a qualitative analysis, we prove that no nonsingular solitary-wave solution exists for the Sakuma-Nishiguchi equation utt-c2uxx-Muxxxx +N(u2xx)xx=0 [Phys. Rev. B 41, 12 117 (1990)], which describes surface acoustic waves in a semi-infinite layered medium with a free surface. From this, we conclude that the solitary-wave solutions obtained by Sakuma and Nishiguchi using the weak-nonlinearity approximation and by Huang using a function-series-solution approach [Phys. Rev. B 44, 3377 (1991)] do not pertain to this model equation.

  17. Traditional Chinese Medicine Induced Liver Injury.

    PubMed

    Teschke, Rolf

    2014-06-01

    Traditional Chinese Medicine (TCM) is popular around the world and encompasses many different practices with particular emphasis on herbal TCM. Using the PubMed database, a literature search was undertaken to assess the extent herbal TCM products exert rare hepatotoxicity. Analysis of reported cases revealed numerous specified herbal TCM products with potential hepatotoxicity. Among these were An Shu Ling, Bai Fang, Bai Xian Pi, Ban Tu Wan, Bo He, Bo Ye Qing Niu Dan, Bofu Tsu Sho San, Boh Gol Zhee, Cang Er Zi, Chai Hu, Chaso, Chi R Yun, Chuan Lian Zi, Ci Wu Jia, Da Chai Hu Tang, Da Huang, Du Huo, Gan Cao, Ge Gen, Ho Shou Wu, Hu Bohe You, Hu Zhang, Huang Qin, Huang Yao Zi, Hwang Geun Cho, Ji Gu Cao, Ji Ji, Ji Xue Cao, Jiguja, Jin Bu Huan, Jue Ming Zi, Kamishoyosan, Kudzu, Lei Gong Teng, Long Dan Xie Gan Tang, Lu Cha, Ma Huang, Mao Guo Tian Jie Cai, Onshido, Polygonum multiflorum, Qian Li Guang, Ren Shen, Sairei To, Shan Chi, Shen Min, Shi Can, Shi Liu Pi, Shou Wu Pian, Tian Hua Fen, White flood, Wu Bei Zi, Xi Shu, Xiao Chai Hu Tang, Yin Chen Hao, Zexie, Zhen Chu Cao, and various unclassified Chinese herbal mixtures. Causality was firmly established for a number of herbal TCM products by a positive reexposure test result, the liver specific scale of CIOMS (Council for International Organizations of Medical Sciences), or both. Otherwise, the quality of case data was mixed, especially regarding analysis of the herb ingredients because of adulteration with synthetic drugs, contamination with heavy metals, and misidentification. In addition, non-herbal TCM elements derived from Agaricus blazei, Agkistrodon, Antelope, Bombyx, Carp, Fish gallbladder, Phellinus, Scolopendra, Scorpio, and Zaocys are also known or potential hepatotoxins. For some patients, the clinical course was severe, with risks for acute liver failure, liver transplantation requirement, and lethality. In conclusion, the use of few herbal TCM products may rarely be associated with hepatotoxicity in some susceptible individuals, necessitating a stringent pretreatment evaluation of the risk/benefit ratio, based on results of multicenter, randomized, double-blind, placebo-controlled clinical trials. PMID:26357619

  18. a Search for Primordial Vortex Remnants in the SDSS

    NASA Astrophysics Data System (ADS)

    Yang, Abel; Ong, Zongjin; Chan, Aik Hui

    2014-04-01

    The scalar field cosmology model proposed by Huang et al.1, 2 predicts that the early pre-inflationary universe was a superfluid. This superfluid is likely to have contained quantized vortices, and it is postulated that remnants of these vortices persist in the present-day moderate-redshift galaxy distribution. We attempt to search for remnants of these primordial vortices in the SDSS BOSS galaxy catalogue. We manage to observe hints of a few vortex tubes, which might lend weight to the credibility of the theory.

  19. Modeling of pervaporation with latex membranes

    SciTech Connect

    Huang, R.Y.M.; Wei, Y. )

    1994-06-01

    Latex membranes have shown potential to be a new type of pervaporation separation membrane. Three types of latex membranes were prepared in our laboratory by direct casting of polymer latexes. These latex membranes were selective toward water during pervaporation with ethanol-water mixtures. The free-volume approach was employed to characterize the pervaporation of these latex membranes. It is shown by this experiment that the Yeom-Huang model, which is based on the free-volume theory and the thermodynamics, can be used to model the pervaporation process of the latex membranes which give reasonable predictions on the permeability. 18 refs., 3 figs., 8 tabs.

  20. Surface tension and perfect wetting in quenched QCD

    NASA Astrophysics Data System (ADS)

    Potvin, Jean; Rebbi, Claudio

    1991-05-01

    We describe a new method for the computation of the surface tension α corresponding to a hadron-plasma interface. On a 16 ∗ 16 ∗ 32 ∗ 4 lattice in hot quenched QCD we find α/ Tc3 = 0.024(4). We then apply the method to the computation of the surface tension between domains of gluonic plasma characterized by different values of the Polyakov line. We find good numerical evidence for perfect wetting in quenched QCD. This work was done in collaboration with R. Brower, S. Huang and J. Ross.

  1. The surface tension in QCD at finite temperature. Study of the surface tension in spin models

    NASA Astrophysics Data System (ADS)

    Potvin, Jean; Rebbi, Claudio

    1990-09-01

    This paper summarizes the contents of two talks delivered at different parallel sessions. We report on the results of a novel approach to the calculationof the surface tension, in the 2- and 3-dimensional Ising model as well as in quenched QCD. We also discuss the use of the Wilson action supplemented with external Polyakov fields as a way to enhance the formation of the interface. This work has involved collaborations with R. Brower, M. Campostrini, S. Huang, H. Gausterer, L. Jacobs, E. Myers and S. Sanielevici.

  2. Valid or not? Yunnan mountain snake Plagiopholis unipostocularis (Serpentes: Colubridae: Pseudoxenodontinae).

    PubMed

    Zhong, Guang Hui; Chen, Wen De; Liu, Qin; Zhu, Fei; Peng, Pei Hao; Guo, Peng

    2015-01-01

    Plagiopholis unipostocularis Zhao, Jiang & Huang, 1978 is a small snake endemic to Yunnan, southern China. Its validity is still controversial and unresolved. Based on extensive sampling in Yunnan, we conducted morphological comparison and molecular phylogenetics on the unidentified specimens of Plagiopholis from Yunnan. Based on a combination of morphological comparison and molecular phylogeny, the newly collected specimens could be identified as P. blakewayi. While some specimens exhibit one or more diagnostics of P. unipostocularis, and some characteristics are intermediate between that of Plagiopholis unipostocularis and P. blakewayi. Thus morphological continuities between two species uncovered P. unipostocularis is a synonymy of P. blakewayi, and the diagnostics of this species was revised accordingly. PMID:26624106

  3. COMMITTEES: SQM2006 Organising and International Advisory Committees

    NASA Astrophysics Data System (ADS)

    2006-12-01

    Organising Committee Kenneth Barish Huan Zhong Huang Joseph Kapusta Grazyna Odyniec Johann Rafelski Charles A Whitten Jr International Advisory Committee Jörg Aichelin Federico Antinori Tamas Biró Jean Cleymans Lazlo Csernai Tim Hallman Ulrich Heinz Sonja Kabana Rob Lacey Yu-Gang Ma Jes Madsen Yasuo Miake Berndt Mueller Grazyna Odyniec Helmut Oeschler Apostolos Panagiotou Johann Rafelski Hans Ritter Karel Safarik Jack Sandweiss Jürgen Schaffner-Bielich Wen-Qing Shen Georges Stephans Horst Stöcker Thomas Ullrich Bill Zajc

  4. A simple model for abrupt millennial climate change in the last glacial period

    NASA Astrophysics Data System (ADS)

    Gottwald, Georg

    2015-04-01

    We first confirm that the time series of Calcium concentrations in GRIP ice-core data exhibits a significant alpha-stable noise component as previously found by Ditlevsen (GRL 1999). Building on recent theoretical results from homogenisation theory for deterministic systems, we propose a simple conceptual entirely deterministic multi-scale model of the ocean-atmosphere-ice system which exhibits alpha-stable behaviour. Unlike in most models employing homogenisation theory we employ here chaotic dynamics exhibiting intermittency. The intermittency is associated with the atmospheric dynamics interacting with sea-ice dynamics. This is joint work with Nathan Duignan, Cameron Duncan and Eric Huang.

  5. Current Flowing In Accretion Disk and State Transition of Black Hole Binaries

    NASA Astrophysics Data System (ADS)

    Wang, Ding-Xiong

    2015-04-01

    The state transition of black hole binaries is discussed based on the evolution of magnetic field configuration, and the latter is related closely to the current flowing in an accretion disk around a black hole. It turns out that the main characteristics of the transition from low/hard state to high/soft state can be fitted by invoking the transportation of current from the outer region to the inner region in accretion process. Chang-Yin Huang is a lecturer working in Yangtze University.

  6. Effect of an allophanic soil on humification reactions between catechol and glycine: Spectroscopic investigations of reaction products

    NASA Astrophysics Data System (ADS)

    Fukushima, Masami; Miura, Akitaka; Sasaki, Masahide; Izumo, Kenji

    2009-01-01

    Adduction of amino acids to phenols is a possible humification reaction pathway [F.J. Stevenson, Humus Chemistry: Genesis, Composition, Reaction, second ed., Wiley, New York, 1994, pp. 188-211; M.C. Wang, P.M. Huang, Sci. Total Environ. 62 (1987) 435; M.C. Wang, P.M. Huang, Soil Sci. Soc. Am. J. 55 (1991) 1156; M.C. Wang, P.M. Huang, Geoderma 112 (2003) 31; M.C. Wang, P.M. Huang, Geoderma 124 (2005) 415]. To elucidate the reaction kinetics and products of abiotic humification, the effects of an allophanic soil on the adduction of amino acids to phenols were investigated using catechol (CT) and glycine (Gly) as a model phenol and amino acid, respectively. An aqueous solution containing CT and Gly (pH 7.0) in the presence of allophanic soil was incubated for 2 weeks, and the kinetics of the humification reactions were monitored by analysis of absorptivity at 600 nm ( E600). A mixture of CT and Gly in the absence of allophanic soil was used as a control. The E600 value increased markedly in the presence of allophanic soil. In addition, unreacted CT was detected in the control reaction mixture, but not in the allophane-containing reaction mixture. Under the sterilized conditions, absorbance at 600 nm for the control reaction mixture was significantly smaller than that for the allophanic soil-containing reaction mixture, which indicates there was no microbial participation during incubation. These results indicate that the allophanic soil effectively facilitated humification reactions between CT and Gly. The reaction mixtures were acidified and humic-like acid (HLA) was isolated as a precipitate. The elemental composition, acidic functional group contents, molecular weight, FT-IR, solid-state CP-MAS 13C NMR, and 1H NMR spectra of the purified HLAs were analyzed. The results of these analyses indicate that the nitrogen atom of Gly binds to the aromatic carbon of CT in the HLA products.

  7. Repeatability observations from a time-lapse seismic survey

    USGS Publications Warehouse

    Walters, S.L.; Miller, R.D.; Raef, A.E.

    2006-01-01

    Time-lapse seismic surveys have proven extremely valuable in recent years, having numerous economical and environmental applications. To fully utilize this monitoring technique, problems associated with recording repeatability must be minimized. Much work has been done to equalize data from one survey to the next via processing techniques (Huang et al., 1998). The purpose of this study is to investigate the potential for minimized processing, allowing study of extremely small changes in subsurface characteristics. The goal is to evaluate source and receiver terrain combination to optimize signal repeatability, and to improve deconvolution with the ground force to suppress different types of noise and increase repeatability. ?? 2005 Society of Exploration Geophysicists.

  8. [Changes of soil physical, chemical and ecological factors under mechanized cultivation].

    PubMed

    Xia, Ping

    2002-03-01

    Three-years agricultural mechanization extension project in Huang-Huai-Hai regions showed that the application of comprehensive agricultural technologies which included the return of straw and stalk to field by mechanization, deep application of fertilizer, deep plough and soil no-tillage with mulch, had an obvious biological effects. In comparing with traditional cultivation, the comprehensive mechanized cultivation could decrease soil bulk density by 0.08 g.cm-3, increase soil organic mater by 12%, improve moisture utilization by 10.1-13.6%, and increase the grain yields of wheat and corn by 1218 kg.hm-2. PMID:12132162

  9. Lane fuzzy collision in channel with potential deformation by photon-phonon-electron excitation and sub-atomic control

    NASA Astrophysics Data System (ADS)

    Shen, Jing

    1998-09-01

    Collision between μ+ and the μ- beams in the crystal are forbidden due to the two beams having different "lanes" in a channel. A laser pulse of ps-fs shocks lattice kernel vibration and dilates lattice electron distribution. It deforms the Lindhard's potential which is then expressed in a quantized form as the Huang-Zhu's potential[1]. The dynamic lanes can be made to overlap in a channel to allow collision without ductile fracture. This raises a new technology of sub-atomic information & control, which has been raised by T. D. Lee.

  10. A generalized tool for accurate time-domain separation of excited modes in spin-torque oscillators

    SciTech Connect

    Siracusano, Giulio Puliafito, Vito; Finocchio, Giovanni

    2014-05-07

    We propose and develop an advanced signal processing technique that, combined with micromagnetic simulations, is able to deeply describe the non-stationary behavior of spin-torque oscillators, both in terms of time domain and spatial distribution of the magnetization dynamics. The Hilbert-Huang Transform is used for the identification of the time traces of each oscillation in a multimode excitation and enhanced with masking signals and the Ensemble Empirical Mode Decomposition. We emphasize that the technique developed here is general and can be used for any physical non-linear system in the presence of multimode dynamical excitation or intermittence.

  11. Pitfalls of mapping high-throughput sequencing data to repetitive sequences: Piwi's genomic targets still not identified.

    PubMed

    Marinov, Georgi K; Wang, Jie; Handler, Dominik; Wold, Barbara J; Weng, Zhiping; Hannon, Gregory J; Aravin, Alexei A; Zamore, Phillip D; Brennecke, Julius; Toth, Katalin Fejes

    2015-03-23

    Huang et al. (2013) recently reported that chromatin immunoprecipitation sequencing (ChIP-seq) reveals the genome-wide sites of occupancy by Piwi, a piRNA-guided Argonaute protein central to transposon silencing in Drosophila. Their study also reported that loss of Piwi causes widespread rewiring of transcriptional patterns, as evidenced by changes in RNA polymerase II occupancy across the genome. Here we reanalyze their data and report that the underlying deep-sequencing dataset does not support the authors' genome-wide conclusions. PMID:25805138

  12. The first Mesozoic microwhip scorpion (Palpigradi): a new genus and species in mid-Cretaceous amber from Myanmar.

    PubMed

    Engel, Michael S; Breitkreuz, Laura C V; Cai, Chenyang; Alvarado, Mabel; Azar, Dany; Huang, Diying

    2016-04-01

    A fossil palpigrade is described and figured from mid-Cretaceous (Cenomanian) amber from northern Myanmar. Electrokoenenia yaksha Engel and Huang, gen. n. et sp. n., is the first Mesozoic fossil of its order and the only one known as an inclusion in amber, the only other fossil being a series of individuals encased in Pliocene onyx marble and 94-97 million years younger than E. yaksha. The genus is distinguished from other members of the order but is remarkably consistent in observable morphological details when compared to extant relatives, likely reflecting a consistent microhabitat and biological preferences over the last 100 million years. PMID:26879963

  13. The first Mesozoic microwhip scorpion (Palpigradi): a new genus and species in mid-Cretaceous amber from Myanmar

    NASA Astrophysics Data System (ADS)

    Engel, Michael S.; Breitkreuz, Laura C. V.; Cai, Chenyang; Alvarado, Mabel; Azar, Dany; Huang, Diying

    2016-04-01

    A fossil palpigrade is described and figured from mid-Cretaceous (Cenomanian) amber from northern Myanmar. Electrokoenenia yaksha Engel and Huang, gen. n. et sp. n., is the first Mesozoic fossil of its order and the only one known as an inclusion in amber, the only other fossil being a series of individuals encased in Pliocene onyx marble and 94-97 million years younger than E. yaksha. The genus is distinguished from other members of the order but is remarkably consistent in observable morphological details when compared to extant relatives, likely reflecting a consistent microhabitat and biological preferences over the last 100 million years.

  14. Acoustical Applications of the HHT Method

    NASA Technical Reports Server (NTRS)

    Huang, Norden E.

    2003-01-01

    A document discusses applications of a method based on the Huang-Hilbert transform (HHT). The method was described, without the HHT name, in Analyzing Time Series Using EMD and Hilbert Spectra (GSC-13817), NASA Tech Briefs, Vol. 24, No. 10 (October 2000), page 63. To recapitulate: The method is especially suitable for analyzing time-series data that represent nonstationary and nonlinear physical phenomena. The method involves the empirical mode decomposition (EMD), in which a complicated signal is decomposed into a finite number of functions, called intrinsic mode functions (IMFs), that admit well-behaved Hilbert transforms. The HHT consists of the combination of EMD and Hilbert spectral analysis.

  15. COMMITTEES: SQM2004 Organising and International Advisory Committees

    NASA Astrophysics Data System (ADS)

    2005-06-01

    Organising Committee Jean Cleymans (Chairman) Zeblon Vilakazi Roger Fearick Peter Steinberg Rory Adams Bruce Becker Sarah Blyth Gareth de Vaux Heather Gray Mark Horner Nawahl Razak Artur Szostak Spencer Wheaton International Advisory Committee Federico Antinori Tim Hallman John Harris Tetsuo Hatsuda Ulrich Heinz Huan Z Huang Sonja Kabana Volker Koch Rob Lacey Jes Madsen Yasuo Miake Maurizio Morando Berndt Mueller Grazyna Odyniec Helmut Oeschler Apostolos Panagiotou Josef Pochodzalla Johann Rafelski Karel Safarik Jack Sandweiss Jürgen Schaffner-Bielich Georges Stephans Horst Stoecker Herbert Stroebele Thomas Ullrich Orlando Villalobos-Baillie Bill Zajc Joseph Zimanyi

  16. Hydrogels: Edge-Hydroxylated Boron Nitride Nanosheets as an Effective Additive to Improve the Thermal Response of Hydrogels (Adv. Mater. 44/2015).

    PubMed

    Xiao, Feng; Naficy, Sina; Casillas, Gilberto; Khan, Majharul H; Katkus, Tomas; Jiang, Lei; Liu, Huakun; Li, Huijun; Huang, Zhenguo

    2015-11-01

    Upon flowing hot-water steam over hexagonal boron nitride (h-BN) bulk powder, efficient exfoliation and hydroxylation of the h-BN occur simultaneously. The edge-hydroxylation enables excellent dispersion of the nanosheets in water and also helps to maintain their high thermal conductivity along the h-BN plane. Used as an additive, the thermal response of a poly(N-isopropylacrylamide) (PNIPAM) hydrogel is dramatically improved, featuring faster shrinkage and dye release. This is described by Z. Huang and co-workers on page 7196. PMID:26634328

  17. Outstanding Student Paper Awards

    NASA Astrophysics Data System (ADS)

    2003-01-01

    The following members in the Space Physics & Aeronomy Section received Outstanding Student Paper Awards at the 2003 AGU Fall Meeting in San Francisco, California. Arve Aksnes; Aroh Barjatya; Jacob Bortnik; Amir Caspi; Ruben Delgado; Galen Fowler; Paul G. Hanlon; Sid Henderson; Tara B. Hiebert; Chia-Lin Huang; Steven P. Joy; Eun-Hwa Kim; Colby Lemon; Yingjuan Ma; Elizabeth A. MacDonald; Jaco Minnie; Mitsuo Oka; Yoshitaka Okazaki; Erin J. Rigler; Ina P. Robertson; Patrick A. Roddy; Sang-Il Roh; Albert Y. Shih; Christopher Smithtro; Emma Spanswick; Maria Spasojevic; Hiroki Tanaka; Linghua Wang; Deirdre E. Wendel; Jichun Zhang>

  18. Outstanding Student Paper Awards

    NASA Astrophysics Data System (ADS)

    2004-04-01

    The following members in the Space Physics & Aeronomy Section received Outstanding Student Paper Awards at the 2003 AGU Fall Meeting in San Francisco, California. Arve Aksnes; Aroh Barjatya; Jacob Bortnik; Amir Caspi; Ruben Delgado; Galen Fowler; Paul G. Hanlon; Sid Henderson; Tara B. Hiebert; Chia-Lin Huang; Steven P. Joy; Eun-Hwa Kim; Colby Lemon; Yingjuan Ma; Elizabeth A. MacDonald; Jaco Minnie; Mitsuo Oka; Yoshitaka Okazaki; Erin J. Rigler; Ina P. Robertson; Patrick A. Roddy; Sang-Il Roh; Albert Y. Shih; Christopher Smithtro; Emma Spanswick; Maria Spasojevic; Hiroki Tanaka; Linghua Wang; Deirdre E. Wendel; Jichun Zhang>

  19. Rectification on the inertial effects for co-axial cylinders rheometer.

    PubMed

    Zhang, J B; Kuang, Z B; Fan, Y

    1998-11-01

    The inertia of the fluid and the inner cylinder in co-axial cylinders rheometer have a great influence on the unsteady flow of non-Newtonian fluid. In the paper this phenomenon is studied minitely and a method to correct the measured results for an unsteady flow in the rheometer is proposed. It was found that the inertia effect of a fluid can be ignored when the gap between cylinders is smaller and the inertia effect of the inner cylinder can be represented with a vibration equation. Using the equation changes of Huang's blood constitutive parameters are observed. PMID:9874358

  20. Nature of the secondary component of beta Lyrae.

    NASA Technical Reports Server (NTRS)

    Stothers, R.; Lucy, L. B.

    1972-01-01

    Development of a hypothesis concerning the nature of the secondary component of beta Lyrae which is regarded as more plausible than the suggestion that this component is a black hole. Adopting Huang's (1962) and Woolf's (1965) basic model for beta Lyrae, it is suggested that the secondary star may be a massive 'main-sequence' star in rapid, nonuniform motion. Certain findings regarding mu Sco and V356 Sgr, which have primaries that are very cool and underluminous for their masses, are cited as evidence for such an inference, since their underluminosity is probably due to high angular momentum and they are normal enough not to be suspected of harboring a black hole.

  1. Hydrochemical study of an arsenic-contaminated plain in Guandu, north Taiwan

    NASA Astrophysics Data System (ADS)

    Hsiao, Yu-Hsiang

    2015-04-01

    Arsenic pollution in Guandu Plain, north Taiwan is a critical issue due to highly developed anthropogenic activities. It was considered that arsenic was carried in by surface water system. Two major rivers, Huanggang Creek and South Huang Greek, flow through Guandu Plain. Both creeks originate from Tatung Volcano Group, which is extensively active in post-volcanic activities. In this study, the hydrochemistry along the two major rivers was studied for tracing the source of arsenic pollution in Guandu Plain. The pH values in the upstream water are in the range from 6 to 8 but dramatically decrease down to 2-4.5 in the downstream area. It can be concluded that the creeks are recharged with very low pH geothermal water. In addition, arsenic shows a different spatial distribution. In Huanggang Creek, arsenic concentration is much higher, about 200 ppb to 500 ppb, in the downstream than in the upstream while arsenic concentration is extremely low, below 1 ppb, in the downstream of South Huang Greek. The geochemical results show that rare earth elements (REEs) are depleted in the upstream both in Huanggang creek and South Huang creek, and the NASC-normalized ratios of heavy to light REE (Lu/La) in the upstream are very close to 1. This demonstrates that the upstream water is geochemically dominated by the interaction between water and sedimentary rock. In the downstream, the NASC-normalized REE pattern shows a quit different type which is depleted in light REEs (much higher Lu/La ratio). It is well known that igneous rock is depleted in light REEs; therefore, arsenic is possibly volcanic origin. In this study, PHREEQC, a thermodynamic modeling program, was also utilized to calculate the saturation index (SI) of hydrous ferric oxide (HFO), which can effectively scavenge arsenic in water. The results demonstrate that SI of HFO is mainly controlled by pH in this study. When pH is greater than 3.5, HFO start to precipitate and remove arsenic from water. Therefore, it is believed that the arsenic pollution in Guandu Plain could result from HFO co-precipitation due to the increase of pH when Huanggang creek and South Huang creek flow through the land.

  2. Toward optical coherence topography

    NASA Astrophysics Data System (ADS)

    Sayegh, Samir; Jiang, Yanshui

    2012-03-01

    Commercial OCT systems provide pachymetry measurements. Full corneal topographic information of anterior and posterior corneal surfaces for use in cataract surgery and refractive procedures is a desirable goal and would add to the usefulness of anterior and posterior segment evaluation. While substantial progress has been made towards obtaining "average" central corneal power (D Huang), power in different meridians and topography are still missing. This is usually reported to be due to eye movement. We analyze the role of centration, eye movements and develop a model that allows for the formulation of criteria for obtaining reliable topographic data within ¼ diopter.

  3. On Components, Latent Variables, PLS and Simple Methods: Reactions to Rigdon's Rethinking of PLS

    PubMed Central

    Bentler, Peter M.; Huang, Wenjing

    2014-01-01

    Rigdon (2012) suggests that partial least squares (PLS) can be improved by killing it, that is, by making it into a different methodology based on components. We provide some history on problems with component-type methods and develop some implications of Rigdon's suggestion. It seems more appropriate to maintain and improve PLS as far as possible, but also to freely utilize alternative models and methods when those are more relevant in certain data analytic situations. Huang's (2013) new consistent and efficient PLSe2 methodology is suggested as a candidate for an improved PLS. PMID:24926106

  4. Pitfalls of mapping high throughput sequencing data to repetitive sequences: Piwi’s genomic targets still not identified

    PubMed Central

    Marinov, Georgi K.; Wang, Jie; Handler, Dominik; Wold, Barbara J.; Weng, Zhiping; Hannon, Gregory J.; Aravin, Alexei A.; Zamore, Phillip D.; Brennecke, Julius; Toth, Katalin Fejes

    2015-01-01

    Huang et al. (2013) recently reported that chromatin immuno-precipitation followed by sequencing (ChIP-seq) reveals the genome-wide sites of occupancy by Piwi - a piRNA-guided Argonaute protein central to transposon silencing in Drosophila. Their study also reported that loss of Piwi causes widespread rewiring of transcriptional patterns as evidenced by changes in RNA polymerase II occupancy across the genome. Here we reanalyze their underlying deep sequencing data and report that the data do not support the author’s central conclusions. PMID:25805138

  5. On vortex dust structures in magnetized dusty plasmas

    SciTech Connect

    Nebbat, E.; Annou, R.

    2010-09-15

    To explain the generation of vortex patterns of dust grains in a magnetized dusty plasma [Huang et al., Plasma Sci. Technol. 9, 1 (2007)], a time dependent nonlinear model that describes vortices as a result of an instability is proposed. Grain-grain as well as grain-ion interactions, particle attachment, and grains drift and diffusion are key elements in the present model. It is found that the latter reproduces the experimental results quite well, whereas the stability analysis shows that the vortex core is grain size dependent.

  6. Neutrino mixing and CP violation from Dirac-Majorana bimaximal mixture and quark-lepton unification

    NASA Astrophysics Data System (ADS)

    Harada, J.

    2006-07-01

    We demonstrate that only two ansätze can produce the features of the neutrino mixing angles. The first ansatz comes from the quark-lepton grand unification; νDi = VCKMνα is satisfied for left-handed neutrinos, where νDi ≡ (νD1,νD2,νD3) are the Dirac mass eigenstates and να ≡ (νe,νμ,ντ) are the flavour eigenstates. The second ansatz comes from the assumption; νDi = Ubimaximalνi is satisfied between the Dirac mass eigenstates νDi and the light Majorana neutrino mass eigenstates νi ≡ (ν1,ν2,ν3), where Ubimaximal is the 3 × 3 rotation matrix that contains two maximal mixing angles and a zero mixing. By these two ansätze, the Maki-Nakagawa-Sakata lepton flavour mixing matrix is given by UMNS = VCKM†Ubimaximal. We find that in this model the novel relation θsol + θ13 = π/4 is satisfied, where θsol and θ13 are solar and CHOOZ angle, respectively. This "Solar-CHOOZ Complementarity" relation indicates that only if the CHOOZ angle θ13 is sizable, the solar angle θsol can deviate from the maximal mixing. Our predictions are θsol = 36°, θ13 = 9° and θatm = 45°, which are consistent with experiments. We also infer the CP violation in neutrino oscillations. The leptonic Dirac CP phase δMNS is predicted as sin δMNS simeq Aλ2η, where A,λ,η are the CKM parameters in Wolfenstein parametrization. In contrast to the quark CP phase δCKM simeq Script O(1), the leptonic Dirac CP phase is very small, δMNS simeq 0.8°. Furthermore, we remark that the ratio of the Jarlskog CP violation factor for quarks and leptons is important, because the large uncertainty on η is cancelled out in the ratio, RJ ≡ JCKM/JMNS simeq 4(2)1/2Aλ3 simeq 5 × 10-2.

  7. Relation between deep bioluminescence and oceanographic variables: A statistical analysis using time-frequency decompositions

    NASA Astrophysics Data System (ADS)

    Martini, S.; Nerini, D.; Tamburini, C.

    2014-09-01

    We consider the statistical analysis of a 1.7-year high-frequency sampled time series, between 2009 and 2010, recorded at the ANTARES observatory in the deep NW Mediterranean Sea (2475 m depth). The objective was to estimate relationships between bioluminescence and environmental time series (temperature, salinity and current speed). As this entire dataset is characterized by non-linearity and non-stationarity, two time-frequency decomposition methods (wavelet and Hilbert-Huang) were used. These mathematical methods are dedicated to the analysis of a signal at various time and frequencies scales. This work propose some statistical tools dedicated to the study of relationships between two time series. Our study highlights three events of high bioluminescence activity in March 2009, December 2009 and March 2010. We demonstrate that the two events occurring in March 2009 and 2010 are correlated to the arrival of newly formed deep water masses at frequencies of approximately 4.8×10-7 (period of 24.1 days). In contrast, the event in December 2009 is only correlated with current speed at frequencies of approximately 1.9×10-6 (period of 6.0 days). The use of both wavelet and Hilbert-Huang transformations has proven to be successful for the analysis of multivariate time series. These methods are well-suited in a context of the increasing number of long time series recorded in oceanography.

  8. Can Medical Herbs Stimulate Regeneration or Neuroprotection and Treat Neuropathic Pain in Chemotherapy-Induced Peripheral Neuropathy?

    PubMed Central

    Schröder, Sven; Beckmann, Kathrin; Franconi, Giovanna; Greten, Henry Johannes; Rostock, Matthias; Efferth, Thomas

    2013-01-01

    Chemotherapy-induced neuropathy (CIPN) has a relevant impact on the quality of life of cancer patients. There are no curative conventional treatments, so further options have to be investigated. We conducted a systematic review in English and Chinese language databases to illuminate the role of medical herbs. 26 relevant studies on 5 single herbs, one extract, one receptor-agonist, and 8 combinations of herbs were identified focusing on the single herbs Acorus calamus rhizoma, Cannabis sativa fructus, Chamomilla matricaria, Ginkgo biloba, Salvia officinalis, Sweet bee venom, Fritillaria cirrhosae bulbus, and the herbal combinations Bu Yang Huan Wu, modified Bu Yang Huan Wu plus Liuwei Di Huang, modified Chai Hu Long Gu Mu Li Wan, Geranii herba plus Aconiti lateralis praeparata radix , Niu Che Sen Qi Wan (Goshajinkigan), Gui Zhi Jia Shu Fu Tang (Keishikajutsubuto), Huang Qi Wu Wu Tang (Ogikeishigomotsuto), and Shao Yao Gan Cao Tang (Shakuyakukanzoto). The knowledge of mechanism of action is still limited, the quality of clinical trials needs further improvement, and studies have not yielded enough evidence to establish a standard practice, but a lot of promising substances have been identified. While CIPN has multiple mechanisms of neuronal degeneration, a combination of herbs or substances might deal with multiple targets for the aim of neuroprotection or neuroregeneration in CIPN. PMID:23983777

  9. Bulk and Compound-Specific Isotope Analysis of Long-Chain, n-alkanes From a 85-kyr Core From Lake Peten Itza, Guatemala

    NASA Astrophysics Data System (ADS)

    Mays, J. L.; Brenner, M.; Bush, M. B.; Correa, A.; Curtis, J. H.; Hodell, D. A.

    2007-12-01

    Drill cores obtained from Lake Petén Itzá, Guatemala, contain a ~85-kyr record of terrestrial climate from lowland Central America. Variations in sediment lithology suggest rapid changes in precipitation during the last glacial and deglacial periods. Previous work in nearby Lake Quexil demonstrated the utility of using the carbon isotopic compositions of leaf wax n-alkanes to infer changes in terrestrial vegetation (Huang et al., 2001). Here we report carbon isotopes of bulk organic and long-chain n-alkanes in 60 samples to reconstruct changes in the relative proportion of C3 and C4 biomass in the watershed under changing climate and atmospheric CO2 conditions during the past 85 kyrs. Compound-specific carbon isotope results are compared directly with pollen analysis from the same samples. Huang, Y., F.A. Street-Perrott, S.E. Metcalfe, M. Brenner, M. Moreland, and K.H. Freeman. 2001. Climate change as the dominant control on glacial-interglacial variations in C3 and C4 plant abundance. Science 293:1647-1651.

  10. A targeted strategy to analyze untargeted mass spectral data: Rapid chemical profiling of Scutellaria baicalensis using ultra-high performance liquid chromatography coupled with hybrid quadrupole orbitrap mass spectrometry and key ion filtering.

    PubMed

    Qiao, Xue; Li, Ru; Song, Wei; Miao, Wen-Juan; Liu, Jia; Chen, Hu-Biao; Guo, De-An; Ye, Min

    2016-04-01

    Structural identification of natural products by tandem mass spectrometry requires laborious spectral analysis. Herein, we report a targeted post-acquisition data processing strategy, key ion filtering (KIF), to analyze untargeted mass spectral data. This strategy includes four steps: (1) untargeted data acquisition by ultra-high performance liquid chromatography coupled with hybrid quadrupole orbitrap mass spectrometry (UHPLC/orbitrap-MS); (2) construction of a key ion database according to diagnostic MS/MS fragmentations and conservative substructures of natural compounds; (3) high-resolution key ion filtering of the acquired data to recognize substructures; and (4) structural identification of target compounds by analyzing their MS/MS spectra. The herbal medicine Huang-Qin (Scutellaria baicalensis Georgi) was used to illustrate this strategy. Its extract was separated within 20min on a C18 column (1.8μm, 2.1×150mm) eluted with acetonitrile, methanol, and water containing 0.1% formic acid. The compounds were detected in the (-)-ESI mode, and their MS/MS spectra were recorded in the untargeted manner. Key ions were then filtered from the LC/MS data to recognize flavones, flavanones, O-/C-glycosides, and phenylethanoid glycosides. Finally, a total of 132 compounds were identified from Huang-Qin, and 59 of them were reported for the first time. This study provides an efficient data processing strategy to rapidly profile the chemical constituents of complicated herbal extracts. PMID:26952367

  11. Neutron Scattering from Magnetically Frustrated Ruthenium Pyrochlores

    NASA Astrophysics Data System (ADS)

    Broholm, Collin

    2008-03-01

    Spin-1 ruthenium pyrochlores feature strong exchange interactions and deeply suppressed N'eel ordering. In addition a doping induced metallic phase has been demonstrated. I discuss neutron scattering experiments that explore the strongly frustrated quantum magnetism of Y2Ru2O7 [1] and Pr2-xBixRu2O7 [2]. In Y2Ru2O7 (θCW= --1100 K, TN=77 K) much of the magnetic spectral weight is concentrated in a 20 meV spectral peak above an 11 meV low temperature gap in the excitation spectrum. In Pr2-xBixRu2O7 magnetic order which occurs for THuang, S.-W. Cheong, C. Broholm, and T. G. Perring, Submitted to Phys. Rev. B Rapid Communications, cond-mat 0707.2678v1 (2007). [2] J. van Duijn, K. H. Kim, N. Hur, D. Adroja, M. A. Adams, Q. Z. Huang, M. Jaime, S.-W. Cheong, C. Broholm, and T. G. Perring, Phys. Rev. Lett. 94, 177201 (2005).

  12. Intrinsic mode functions locate implicit turbulent attractors in time in frontal lobe MEG recordings.

    PubMed

    Huang, X; Huang, L; Jung, T-P; Cheng, C-K; Mandell, A J

    2014-05-16

    In seeking evidence for the presence and characteristic range of coupled time scale(s) of putative implicit turbulent attractors of dorsal frontal lobe magnetic fields, the recorded nonstationary, nonlinear MEG signals were non-orthogonally decomposed using Huang's Empirical Mode Decomposition, EMD, (Huang and Attoh-Okine, 2005) into 16 Intrinsic Mode Functions, EMD→IMFi, i=1…16. Measures known to be invariant in non-uniformly hyperbolic (turbulent) dynamical systems, topological entropy, hT, metric entropy, hM, non-uniform entropy, hU and power spectral scaling exponent, α, were imposed on each of the IMFi which evidenced most clearly an invariant temporal scale zone of IMFi, i=6…11, for hT, which we have found to be the most robust of invariant measures of MEG's magnetic field turbulent attractors (Mandell et al., 2011a,b; Mandell, 2013). The ergodic theory of dynamical systems (Walters, 1982; Pollicott and Yuri, 1998) allows the inference that an implicit attractor with consistently hT>0 will also evidence at least one positive Lyapounov exponent indicating the presence of a turbulent attractor with exponential separation of nearby initial conditions, exponential convergence of distant points and disordering, mixing, of orbital sequences. It appears that this approach permits the inference of the presence of chaotic, turbulent attractor and its characteristic time scales without the invocation of arbitrary n-dimensional embedding, phase space reconstructions or (inappropriate) orthogonal decompositions. PMID:24613718

  13. The geoid computed from a new generalized theory of the figure of the Earth

    NASA Astrophysics Data System (ADS)

    Huang, Cheng-li; Liu, Cheng-jun; Liu, Yu

    2012-08-01

    The geoid serves as the reference frame in geodesy. The Clairaut equation, Darwin - de Sitter theory and the series work of Denis are regarded as the standard theories of equilibrium figures of the Earth to the first - , second - , and third - order precision, respectively. Recently, a new generalized theory to obtain the interior figures to third - order accuracy was developed (Liu & Huang, 2008; Huang & Liu, 2012), in which, both the direct and indirect contribution of the anti - symmetric crust layer are included, thus, all the non - zero order and odd degree terms, up to degree/order of six, are included in the spherical harmonic expression of the equilibrium figures. As a result, the global dynamical flattening (H) was obtained as 1/306.68, i.e., the difference of H between the calculated value from above traditional theories and the value from precession observations is reduced from 1.1%, by about 2/3, to 0.38%. In this presentation, based on the above new generalized theory, the geoid is calculated and compared with the one derived from EGM96. Some further discussion will be also presented.

  14. Commodity Tracker: Mobile Application for Food Security Monitoring in Haiti

    NASA Astrophysics Data System (ADS)

    Chiu, M. T.; Huang, X.; Baird, J.; Gourley, J. R.; Morelli, R.; de Lanerolle, T. R.; Haiti Food Security Monitoring Mobile App Team

    2011-12-01

    Megan Chiu, Jason Baird, Xu Huang, Trishan de Lanerolle, Ralph Morelli, Jonathan Gourley Trinity College, Computer Science Department and Environmental Science Program, 300 Summit Street, Hartford, CT 06106 megan.chiu@trincoll.edu, Jason.baird@trincoll.edu, xu.huang@trincoll.edu, trishan.delanerolle@trincoll.edu, ralph.morelli@trincoll.edu, jonathan.gourley@trincoll.edu Price data for Haiti commodities such as rice and potatoes have been traditionally recorded by hand on paper forms for many years. The information is then entered onto computer manually, thus making the process a long and arduous one. With the development of the Haiti Commodity Tracker mobile app, we are able to make this commodity price data recording process more efficient. Officials may use this information for making inferences about the difference in commodity prices and for food distribution during critical time after natural disasters. This information can also be utilized by governments and aid agencies on their food assistance programs. Agronomists record the item prices from several sample sites in a marketplace and compare those results from other markets across the region. Due to limited connectivity in rural areas, data is first saved to the phone's database and then retransmitted to a central server via SMS messaging. The mobile app is currently being field tested by an international NGO providing agricultural aid and support in rural Haiti.

  15. Characterization of Na+- beta-Zeolite Supported Pd and Pd Ag Bimetallic Catalysts using EXAFS, TEM and Flow Reactor

    SciTech Connect

    Huang,W.; Lobo, R.; Chen, J.

    2008-01-01

    Flow reactor studies of the selective hydrogenation of acetylene in the presence of ethylene have been performed on Na+ exchanged {beta}-zeolite supported Pd, Ag and PdAg catalysts, as an extension of our previous batch reactor studies [W. Huang, J.R. McCormick, R.F. Lobo, J.G. Chen, J. Catal. 246 (2007) 40-51]. Results from flow reactor studies show that the PdAg/Na+-{beta}-zeolite bimetallic catalyst has lower activity than Pd/Na+-{beta}-zeolite monometallic catalyst, while Ag/Na+-{beta}-zeolite does not show any activity for acetylene hydrogenation. However, the selectivity for the PdAg bimetallic catalyst is much higher than that for either the Pd catalyst or Ag catalyst. The selectivity to byproduct (ethane) is greatly inhibited on the PdAg bimetallic catalyst as well. The results from the current flow reactor studies confirmed the pervious results from batch reactor studies [W. Huang, J.R. McCormick, R.F. Lobo, J.G. Chen, J. Catal. 246 (2007) 40-51]. In addition, we used transmission electron microscope (TEM), extended X-ray absorption fine structure (EXAFS), and FTIR of CO adsorption to confirm the formation of Pd-Ag bimetallic alloy in the PdAg/Na+-{beta}-zeolite catalyst.

  16. Broadband enhanced transmission of acoustic waves through serrated metal gratings

    NASA Astrophysics Data System (ADS)

    Qi, Dong-Xiang; Fan, Ren-Hao; Deng, Yu-Qiang; Peng, Ru-Wen; Wang, Mu; Jiangnan University Collaboration

    In this talk, we present our studies on broadband properties of acoustic waves through metal gratings. We have demonstrated that serrated metal gratings, which introduce gradient coatings, can give rise to broadband transmission enhancement of acoustic waves. Here, we have experimentally and theoretically studied the acoustic transmission properties of metal gratings with or without serrated boundaries. The average transmission is obviously enhanced for serrated metal gratings within a wide frequency range, while the Fabry-Perot resonance is significantly suppressed. An effective medium hypothesis with varying acoustic impedance is proposed to analyze the mechanism, which was verified through comparison with finite-element simulation. The serrated boundary supplies gradient mass distribution and gradient normal acoustic impedance, which could efficiently reduce the boundary reflection. Further, by increasing the region of the serrated boundary, we present a broadband high-transmission grating for wide range of incident angle. Our results may have potential applications to broadband acoustic imaging, acoustic sensing and new acoustic devices. References: [1] Dong-Xiang Qi, Yu-Qiang Deng, Di-Hu Xu, Ren-Hao Fan, Ru-Wen Peng, Ze-Guo Chen, Ming-Hui Lu, X. R. Huang and Mu Wang, Appl. Phys. Lett. 106, 011906 (2015); [2] Dong-Xiang Qi, Ren-Hao Fan, Ru-Wen Peng, Xian-Rong Huang, Ming-Hui Lu, Xu Ni, Qing Hu, and Mu Wang, Applied Physics Letters 101, 061912 (2012).

  17. Diagnostics of gear faults based on EMD and automatic selection of intrinsic mode functions

    NASA Astrophysics Data System (ADS)

    Ricci, Roberto; Pennacchi, Paolo

    2011-04-01

    Signal processing is an important tool for diagnostics of mechanical systems. Many different techniques are available to process experimental signals, among others: FFT, wavelet transform, cepstrum, demodulation analysis, second order ciclostationarity analysis, etc. However, often hypothesis about data and computational efforts restrict the application of some techniques. In order to overcome these limitations, the empirical mode decomposition has been proposed. The outputs of this adaptive approach are the intrinsic mode functions that are treated with the Hilbert transform in order to obtain the Hilbert-Huang spectrum. Anyhow, the selection of the intrinsic mode functions used for the calculation of Hilbert-Huang spectrum is normally done on the basis of user's experience. On the contrary, in the paper a merit index is introduced that allows the automatic selection of the intrinsic mode functions that should be used. The effectiveness of the improvement is proven by the result of the experimental tests presented and performed on a test-rig equipped with a spiral bevel gearbox, whose high contact ratio made difficult to diagnose also serious damages of the gears. This kind of gearbox is normally never employed for benchmarking diagnostics techniques. By using the merit index, the defective gearbox is always univocally identified, also considering transient operating conditions.

  18. Observations of exciton-surface plasmon polariton coupling and exciton-phonon coupling in InGaN/GaN quantum wells covered with Au, Ag, and Al films

    NASA Astrophysics Data System (ADS)

    Estrin, Y.; Rich, D. H.; Keller, S.; DenBaars, S. P.

    2015-07-01

    The coupling of excitons to surface plasmon polaritons (SPPs) and longitudinal optical (LO) phonons in Au-, Ag-, and Al-coated InxGa1-xN/GaN multiple and single quantum wells (SQWs) was studied with time-resolved cathodoluminescence (CL) and CL wavelength imaging techniques. Excitons were generated in the metal-coated SQWs by injecting a pulsed high-energy electron beam through the thin metal films, which is found to be an ideal method of excitation for plasmonic quantum heterostructures and nanostructures which are opaque to laser/light excitation. The Purcell enhancement factor (Fp) at low temperatures was obtained by the direct measurement of changes in the carrier lifetime caused by the SQW excitonSPP coupling. The deposition of thin films of Al, Ag, and Au on an InGaN/GaN QW enabled a comparison of excitonSPP coupling for energy ranges in which the surface plasmon energy is greater than, approximately equal to, and less than the QW excitonic transition energy. We investigated the temperature dependence of the Huang-Rhys factors for exciton-to-LO phonon coupling for the metal-covered and bare samples. CL imaging and spectroscopy with variable excitation densities are used to examine the spatial correlations between CL emission intensity, carrier lifetime, QW excitonic emission energy, and the Huang-Rhys factor, all of which are strongly influenced by local fluctuations in the In composition and formation of InN-rich centers.

  19. Contributions to the knowledge of subterranean trechine beetles in southern China’s karsts: five new genera (Insecta, Coleoptera, Carabidae, Trechinae)

    PubMed Central

    Tian, Mingyi; Huang, Sunbin; Wang, Xinhui; Tang, Mingruo

    2016-01-01

    Abstract Recent discoveries reveal that southern China’s karsts hold the most diverse and morphologically modified subterranean trechine beetles in the world, albeit the first troglobitic blind beetle was only reported in the early 1990’s. In total, 110 species belonging to 43 genera of cavernicolous trechines have hitherto been recorded from the karsts of southern China, including the following five new genera proposed below: Shiqianaphaenops Tian, gen. n., to contain two species: Shiqianaphaenops majusculus (Uéno, 1999) (= Shenaphaenops majusculus Uéno, 1999, comb. n.), the type species from Cave Feng Dong, Shiqian, Guizhou, and Shiqianaphaenops cursor (Uéno, 1999) (= Shenaphaenops cursor Uéno, 1999, comb. n.), from Cave Shenxian Dong, Shiqian, Guizhou; and the monotypic Dianotrechus Tian, gen. n. (the type species: Dianotrechus gueorguievi Tian, sp. n., from Cave Dashi Dong, Kunming, Yunnan), Tianeotrechus Tian & Tang, gen. n. (the type species: Tianeotrechus trisetosus Tian & Tang, sp. n., from Cave Bahao Dong, Tian’e County, Guangxi), Huoyanodytes Tian & Huang, gen. n. (the type species: Huoyanodytes tujiaphilus Tian & Huang, sp. n., from Longshan, Hunan) and Wanhuaphaenops Tian & Wang, gen. n. (the type species: Wanhuaphaenops zhangi Tian & Wang, sp. n., from Cave Songjia Dong, Chenzhou, Hunan). PMID:27081334

  20. Can medical herbs stimulate regeneration or neuroprotection and treat neuropathic pain in chemotherapy-induced peripheral neuropathy?

    PubMed

    Schröder, Sven; Beckmann, Kathrin; Franconi, Giovanna; Meyer-Hamme, Gesa; Friedemann, Thomas; Greten, Henry Johannes; Rostock, Matthias; Efferth, Thomas

    2013-01-01

    Chemotherapy-induced neuropathy (CIPN) has a relevant impact on the quality of life of cancer patients. There are no curative conventional treatments, so further options have to be investigated. We conducted a systematic review in English and Chinese language databases to illuminate the role of medical herbs. 26 relevant studies on 5 single herbs, one extract, one receptor-agonist, and 8 combinations of herbs were identified focusing on the single herbs Acorus calamus rhizoma, Cannabis sativa fructus, Chamomilla matricaria, Ginkgo biloba, Salvia officinalis, Sweet bee venom, Fritillaria cirrhosae bulbus, and the herbal combinations Bu Yang Huan Wu, modified Bu Yang Huan Wu plus Liuwei Di Huang, modified Chai Hu Long Gu Mu Li Wan, Geranii herba plus Aconiti lateralis praeparata radix , Niu Che Sen Qi Wan (Goshajinkigan), Gui Zhi Jia Shu Fu Tang (Keishikajutsubuto), Huang Qi Wu Wu Tang (Ogikeishigomotsuto), and Shao Yao Gan Cao Tang (Shakuyakukanzoto). The knowledge of mechanism of action is still limited, the quality of clinical trials needs further improvement, and studies have not yielded enough evidence to establish a standard practice, but a lot of promising substances have been identified. While CIPN has multiple mechanisms of neuronal degeneration, a combination of herbs or substances might deal with multiple targets for the aim of neuroprotection or neuroregeneration in CIPN. PMID:23983777

  1. Investigation of antioxidant interactions between Radix Astragali and Cimicifuga foetida and identification of synergistic antioxidant compounds.

    PubMed

    Wang, Fei; Zhao, Shancang; Li, Feng; Zhang, Bo; Qu, Yi; Sun, Tianlei; Luo, Ting; Li, Dapeng

    2014-01-01

    The medicinal plants of Huang-qi (Radix Astragali) and Sheng-ma (Cimicifuga foetida) demonstrate significantly better antioxidant effects when used in combination than when used alone. However, the bioactive components and interactional mechanism underlying this synergistic action are still not well understood. In the present study, 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay was employed to investigate the antioxidant capacity of single herbs and their combination with the purpose of screening synergistic antioxidant compounds from them. Chromatographic isolation was performed on silica gel, Sephadex LH-20 columns and HPLC, and consequently to yield formononetin, calycosin, ferulic acid and isoferulic acid, which were identified by their retention time, UV ?max, MS and MS/MS data. The combination of isoferulic acid and calycosin at a dose ratio of 1?1 resulted in significant synergy in scavenging DPPH radicals and ferric reducing antioxidant power (FRAP) assay. Furthermore, the protective effects of these four potential synergistic compounds were examined using H2O2-induced HepG2 Cells bioassay. Results revealed that the similar synergy was observed in the combination of isoferulic acid and calycosin. These findings might provide some theoretical basis for the purported synergistic efficiency of Huang-qi and Sheng-ma as functional foods, dietary supplements and medicinal drugs. PMID:24498048

  2. Invited Commentary: Does Neonatal Hyperbilirubinemia Cause Asthma?

    PubMed Central

    Kuzniewicz, Michael W.; Wickremasinghe, Andrea C.; Newman, Thomas B.

    2013-01-01

    In an analysis of data from the US Collaborative Perinatal Project, Huang et al. (Am J Epidemiol. 2013;178(12):1691–1697) report an association between neonatal total serum bilirubin levels and childhood asthma. To consider the implications of this finding, we need to evaluate whether the association is causal. The results do not appear to be due to chance or any obvious biases. It is likely that the observed association is the result of a common cause of both hyperbilirubinemia and asthma (confounding). Polymorphisms in the glutathione S-transferase gene are a potential genetic confounder. The glutathione S-transferase M1-null phenotype has been linked to both neonatal hyperbilirubinemia and asthma in several studies. Before making any changes in practice aimed at lowering peak bilirubin levels to reduce asthma risk, it is vital to determine not only whether the association between higher bilirubin levels and asthma risk is causal, but also whether interventions to reduce peak bilirubin levels (or their duration) are associated with decreased risk of asthma (without evidence of other adverse effects). The study by Huang et al. should encourage further investigation of these questions. PMID:24186968

  3. Computing a Stability Spectrum by Use of the HHT

    NASA Technical Reports Server (NTRS)

    Huang, Norden E.

    2007-01-01

    The Hilbert-Huang transform (HHT) is part of the mathematical basis of a method of calculating a stability spectrum. This method can be regarded as an extended and improved version of a prior HHT-based method of calculating a damping spectrum. In the prior method, information on positive damping (which leads to stability) and negative damping (which leads to instability) becomes mixed into a single squared damping loss factor. Hence, there is no way to distinguish between stability and instability by examining a damping spectrum. In contrast, in the present stabilityspectrum method, information on the mathematical sign of the damping is retained, making it possible to identify reThe Hilbert-Huang transform (HHT) is part of the mathematical basis of a method of calculating a stability spectrum. This method can be regarded as an extended and improved version of a prior HHT-based method of calculating a damping spectrum. In the prior method, information on positive damping (which leads to stability) and negative damping (which leads to instability) becomes mixed into a single squared damping loss factor. Hence, there is no way to distinguish between stability and instability by examining a damping spectrum. In contrast, in the present stabilityspectrum method, information on the mathematical sign of the damping is retained, making it possible to identify regions of instability in a spectrum. This method is expected to be especially useful for analyzing vibration-test data for the purpose of predicting vibrational instabilities in structures (e.g., flutter in airplane wings).

  4. New expectations from the well-known medicinal properties of Arctium lappa.

    PubMed

    Miele, C; Beguinot, F

    2012-05-01

    AMP-activated protein kinase (AMPK) serves as a major regulator of energy homeostasis and is activated by different glucose-lowering agents. Indeed, AMPK has been identified as an attractive target for the development of innovative molecules to treat type 2 diabetes. In this issue of Diabetologia (doi: 10.1007/s00125-011-2366-3 ), Huang and co-workers report that arctigenin activates muscle uptake of glucose and inhibits hepatocyte gluconeogenesis and lipogenesis by reducing mitochondrial respiration and inducing AMPK activity. Importantly, it is reported that arctigenin improves glucose and lipid metabolism in ob/ob mice. Based on this evidence, Huang and co-workers suggest that arctigenin may represent a valuable lead compound for developing innovative glucose-lowering molecules. While these findings are not entirely novel and mechanistic investigations are needed, the results strongly support the concept that arctigenin deserves to be further considered because of its several potentially beneficial in vivo effects. In particular, the authors conclude that further mechanistic studies on arctigenin might provide novel insight and opportunities for selective modulation of subcutaneous and visceral fat mass. PMID:22358500

  5. Thermoelectric transport in ZnO and GaN nanowires

    NASA Astrophysics Data System (ADS)

    Galagali, S. M.; Sankeshwar, N. S.; Mulimani, B. G.

    2015-08-01

    Thermoelectric transport properties - electron mobility, μ, diffusion thermopower, Sd, and electronic thermal conductivity, κe - are investigated in ZnO and GaN nanowires (NWs) for 10Huang et al. [2] [Y. Huang, X.F. Duan, Y. Cui, C.M. Lieber, Nano Lett. 2 (2002), 101]. Detailed studies for ultrathin NWs are required to better understand electron-phonon interaction in these systems.

  6. Synthesis of artificial spectrum-compatible seismic accelerograms

    NASA Astrophysics Data System (ADS)

    Vrochidou, E.; Alvanitopoulos, P. F.; Andreadis, I.; Elenas, A.; Mallousi, K.

    2014-08-01

    The Hilbert-Huang transform is used to generate artificial seismic signals compatible with the acceleration spectra of natural seismic records. Artificial spectrum-compatible accelerograms are utilized instead of natural earthquake records for the dynamic response analysis of many critical structures such as hospitals, bridges, and power plants. The realistic estimation of the seismic response of structures involves nonlinear dynamic analysis. Moreover, it requires seismic accelerograms representative of the actual ground acceleration time histories expected at the site of interest. Unfortunately, not many actual records of different seismic intensities are available for many regions. In addition, a large number of seismic accelerograms are required to perform a series of nonlinear dynamic analyses for a reliable statistical investigation of the structural behavior under earthquake excitation. These are the main motivations for generating artificial spectrum-compatible seismic accelerograms and could be useful in earthquake engineering for dynamic analysis and design of buildings. According to the proposed method, a single natural earthquake record is deconstructed into amplitude and frequency components using the Hilbert-Huang transform. The proposed method is illustrated by studying 20 natural seismic records with different characteristics such as different frequency content, amplitude, and duration. Experimental results reveal the efficiency of the proposed method in comparison with well-established and industrial methods in the literature.

  7. AC electrokinetics of dense inhomogeneous biological cells suspensions under nonuniform applied fields

    NASA Astrophysics Data System (ADS)

    Chan, K. L.; Huang, J. P.; Yu, K. W.

    2008-03-01

    When a biological cell is placed in a nonuniform AC (or DC) electric field, force would be induced because of the interaction between the induced electric dipole moment of the particle and the external electric field. This phenomenon is called dielectrophoresis (DEP). [1] In this study a new method is proposed to handle biological cells with arbitrary permittivity and conductivity profiles, and determine the importance of multipole effect as compared with the approximate point dipole calculation [2], which is valid if the external field is homogeneous. In real situations, cells often possess arbitrary graded profiles and the study of higher multipole effects can lead to a better understanding. We also extend the calculation to dense cells suspensions by the effective medium theories [3]. The study reveals significant effects on the DEP due to higher concentration. [1] T. B. Jones, Electromechanics of particles, Cambridge University Press, 1995 [2] C. Z. Fan, J. P. Huang, K. W. Yu, J. Phys. Chem. B, 110, 25665 (2006). [3] J. P. Huang, K. W. Yu, Physics Reports 431, 87 (2006).

  8. The lowest triplet states of bridged cis-2,2'-bithiophenes - theory vs. experiment.

    PubMed

    Andrzejak, Marcin; Szczepanik, Dariusz W; Orzeł, Łukasz

    2015-02-21

    Theoretical methods that were previously used to give a good quantitative description of the 3(1)Bu state of trans-2,2'-bithiophene are applied to characterize the lowest triplet states of three bridged cis-2,2'-bithiophenes: 3,3'-cyclopentadithiophene (CPDT), 3,3'-dithienylpyrrole (DTP), and 3,3'-dithienylthiophene (DTT). By obtaining highly accurate reproductions of the phosphorescence spectra of all three compounds, we rationalize the observed vibronic activity, further explore the performance of the applied theoretical methods, and address the quality of the reported experimental spectra. Over the course of this study we have, first, characterized the changes in the electronic structures between the ground state and the lowest triplet state and, second, expressed the related geometrical differences in terms of the Huang-Rhys factors. The Huang-Rhys factors have then been used to generate theoretical emission spectra with vibronic resolution. The applied procedure has yielded quantitative reproductions of the previously reported experimental phosphorescence spectra of DTT and DTP. The experimental spectrum of CPDT, on the other hand, turned out to be considerably narrower and intensity-deficient in its low energy region when compared with the theoretical results. Our experimental reinvestigation of the CPDT phosphorescence has given a refined spectrum that is significantly wider than the previously reported one, and is in nearly quantitative agreement with the theoretical prediction. This enabled us to attribute the observed discrepancy to an experimental artifact associated with the sensitivity characteristics of the commonly used photomultipliers. PMID:25609244

  9. Investigation of Antioxidant Interactions between Radix Astragali and Cimicifuga foetida and Identification of Synergistic Antioxidant Compounds

    PubMed Central

    Wang, Fei; Zhao, Shancang; Li, Feng; Zhang, Bo; Qu, Yi; Sun, Tianlei; Luo, Ting; Li, Dapeng

    2014-01-01

    The medicinal plants of Huang-qi (Radix Astragali) and Sheng-ma (Cimicifuga foetida) demonstrate significantly better antioxidant effects when used in combination than when used alone. However, the bioactive components and interactional mechanism underlying this synergistic action are still not well understood. In the present study, 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay was employed to investigate the antioxidant capacity of single herbs and their combination with the purpose of screening synergistic antioxidant compounds from them. Chromatographic isolation was performed on silica gel, Sephadex LH-20 columns and HPLC, and consequently to yield formononetin, calycosin, ferulic acid and isoferulic acid, which were identified by their retention time, UV λmax, MS and MS/MS data. The combination of isoferulic acid and calycosin at a dose ratio of 1∶1 resulted in significant synergy in scavenging DPPH radicals and ferric reducing antioxidant power (FRAP) assay. Furthermore, the protective effects of these four potential synergistic compounds were examined using H2O2-induced HepG2 Cells bioassay. Results revealed that the similar synergy was observed in the combination of isoferulic acid and calycosin. These findings might provide some theoretical basis for the purported synergistic efficiency of Huang-qi and Sheng-ma as functional foods, dietary supplements and medicinal drugs. PMID:24498048

  10. Observations of exciton-surface plasmon polariton coupling and exciton-phonon coupling in InGaN/GaN quantum wells covered with Au, Ag, and Al films.

    PubMed

    Estrin, Y; Rich, D H; Keller, S; DenBaars, S P

    2015-07-01

    The coupling of excitons to surface plasmon polaritons (SPPs) and longitudinal optical (LO) phonons in Au-, Ag-, and Al-coated InxGa1-xN/GaN multiple and single quantum wells (SQWs) was studied with time-resolved cathodoluminescence (CL) and CL wavelength imaging techniques. Excitons were generated in the metal-coated SQWs by injecting a pulsed high-energy electron beam through the thin metal films, which is found to be an ideal method of excitation for plasmonic quantum heterostructures and nanostructures which are opaque to laser/light excitation. The Purcell enhancement factor (Fp) at low temperatures was obtained by the direct measurement of changes in the carrier lifetime caused by the SQW exciton-SPP coupling. The deposition of thin films of Al, Ag, and Au on an InGaN/GaN QW enabled a comparison of exciton-SPP coupling for energy ranges in which the surface plasmon energy is greater than, approximately equal to, and less than the QW excitonic transition energy. We investigated the temperature dependence of the Huang-Rhys factors for exciton-to-LO phonon coupling for the metal-covered and bare samples. CL imaging and spectroscopy with variable excitation densities are used to examine the spatial correlations between CL emission intensity, carrier lifetime, QW excitonic emission energy, and the Huang-Rhys factor, all of which are strongly influenced by local fluctuations in the In composition and formation of InN-rich centers. PMID:26076324

  11. Optimal Gaussian squeezed states for atom interferometry in the presence of phase diffusion

    SciTech Connect

    Tikhonenkov, Igor; Moore, Michael G.; Vardi, Amichay

    2010-10-15

    We optimize the signal-to-noise ratio of a Mach-Zehnder atom interferometer with Gaussian squeezed input states in the presence interactions. For weak interactions, our results coincide with those of Huang and Moore [Y. P. Huang and M. G. Moore, Phys. Rev. Lett. 100, 250406 (2008)], with an optimal initial number variance {sigma}{sub o{proportional_to}}N{sup 1/3} and an optimal signal-to-noise ratio s{sub o{proportional_to}}N{sup 2/3} for the total atom number N. As the interaction strength u increases past unity, phase diffusion becomes dominant, leading to a transition in the optimal squeezing from initial number squeezing to initial phase squeezing with {sigma}{sub o{proportional_to}{radical}}(uN) and s{sub o{proportional_to}{radical}}(N/u) shot-noise scaling. The initial phase squeezing translates into hold-time number squeezing, which is less sensitive to interactions than coherent states and improves s{sub o} by a factor of {radical}(u).

  12. Availability of weight-loss supplements: Results of an audit of retail outlets in a southeastern city.

    PubMed

    Sharpe, Patricia A; Granner, Michelle L; Conway, Joan M; Ainsworth, Barbara E; Dobre, Mirela

    2006-12-01

    The sale of nonprescription weight-loss products accounts for millions of dollars spent by Americans trying to lose weight, yet there is little evidence for effectiveness and there are multiple safety concerns. The purpose of this study was to determine what products, and ingredients within products, were available at retail outlets in a metropolitan area. A purposive sampling strategy identified 73 retail outlets. An audit form was used to collect information from product labels. The audit identified 402 products containing 4,053 separate ingredients. The mean number of ingredients per product was 9.9+/-8.96 (range = 1 to 96). A database search was conducted regarding evidence for effectiveness, safety precautions, and side effects for the 10 ingredients that appeared most often across products. Modest evidence of effectiveness exists for green tea (Camellia sinensis), chromium picolinate, and ma huang (Ephedra major). For the remaining seven (ginger root [Zingiber officinale], guarana [Paullinia cupana], hydroxycitric acid [Garcinia cambogia], white willow [Salix alba], Siberian ginseng [Eleutherococcus senticosus], cayenne [Capsicum annuum], and bitter orange/zhi shi [Citrus aurantium]), inadequate or negative evidence exists. Although precautions and contraindications were found for all 10 ingredients, the strongest concerns in the literature appear for ma huang, bitter orange, and guarana. Our audit revealed numerous weight-loss products available to consumers, yet there is little evidence to support the effectiveness of the top 10 ingredients identified and many potential adverse reactions; therefore, food and nutrition professionals should discuss dietary supplement use with their clients. PMID:17126636

  13. Modelling of in vitro chondrocyte detachment

    NASA Astrophysics Data System (ADS)

    McGarry, J. P.; McHugh, P. E.

    The experimental work of Huang et al. [Huang, W., Bahman, A., Torres, J.H., LeBaron R.G., Athanasiou, K.A., 2003. Temporal effects of cell adhesion on mechanical characteristics of the single chondrocyte. J. Orthop. Res. 21, 88-95] provides a novel experimental characterisation of the force required to detach single chondrocytes from a flat substrate with a horizontally moving probe. Measurements reveal that the force required to detach cells spread for six hours is eleven times greater than that required to detach cells spread for one hour. However, it is not clear if this phenomenon is entirely due to geometric changes of chondrocytes during spreading and the consequent increase in adhesion area between cell and substrate. The current computational study, using experimentally measured cell geometries and a cohesive zone model to simulate the cell-substrate interface, reveals that this is not the case. It is demonstrated that both an increase in cell stiffness and an increase in the cell-substrate interface strength during cell spreading are necessary to explain the experimental measurements. It is also revealed that the mechanism of cell detachment involves exclusively tangential debonding, with no lifting of the cell taking place at the cell-substrate interface. Finally, the effect of discrete focal adhesion regions on cell detachment is considered.

  14. The Use of Covariates and Random Effects in Evaluating Predictive Biomarkers Under a Potential Outcome Framework

    PubMed Central

    Zhang, Zhiwei; Nie, Lei; Soon, Guoxing; Liu, Aiyi

    2016-01-01

    Predictive or treatment selection biomarkers are usually evaluated in a subgroup or regression analysis with focus on the treatment-by-marker interaction. Under a potential outcome framework (Huang, Gilbert and Janes [Biometrics 68 (2012) 687696]), a predictive biomarker is considered a predictor for a desirable treatment benefit (defined by comparing potential outcomes for different treatments) and evaluated using familiar concepts in prediction and classification. However, the desired treatment benefit is un-observable because each patient can receive only one treatment in a typical study. Huang et al. overcome this problem by assuming monotonicity of potential outcomes, with one treatment dominating the other in all patients. Motivated by an HIV example that appears to violate the monotonicity assumption, we propose a different approach based on covariates and random effects for evaluating predictive biomarkers under the potential outcome framework. Under the proposed approach, the parameters of interest can be identified by assuming conditional independence of potential outcomes given observed covariates, and a sensitivity analysis can be performed by incorporating an unobserved random effect that accounts for any residual dependence. Application of this approach to the motivating example shows that baseline viral load and CD4 cell count are both useful as predictive biomarkers for choosing antiretroviral drugs for treatment-naive patients. PMID:26779295

  15. A Variational Study of Passive Scalar Decay with the Amplitude Mapping Closure

    NASA Astrophysics Data System (ADS)

    Eyink, Gregory L.

    1997-11-01

    We use the Statistical Rayleigh-Ritz Method (SRRM) to study passive scalar decay. SRRM makes computational use of the exact dynamical equations in regimes currently inaccessible to Direct Numerical Simulation (DNS), by exploiting intuitive guesses or Ansätze for the system statistics ( G. L. Eyink, Phys. Rev. E, 54) 3419 (1996). The method is applied here to the advection-diffusion equations within the amplitude mapping closure (H. Chen, S. Chen, and R. H. Kraichnan, Phys. Rev. Lett. 63) 2657 (1989). We derive all multi-time scalar correlations simultaneously by studying the statistical histories of the ``fine-grained'' or ``empirical'' PDF. For this quantity we derive an effective action of Onsager-Machlup type, formally equivalent to a stochastic Langevin model. The amplitude mapping Ansatz is shown to lead to a realizability failure for predicted multi-time statistics, due to the arbitrariness of scalar decay rate. Because this realizability breakdown is restricted to moments of quadratic order or lower, it is still meaningful to compare with experiment for higher moments. For mapping closure with a time-dependent Gaussian reference field (S. Girimaji, Phys. Fluids A 4) 2875 (1992), we present analytical solutions of joint two-time PDF's of the scalar with an initial PDF either Gaussian or double-delta.

  16. Confronting effective models for deconfinement in dense quark matter with lattice data

    NASA Astrophysics Data System (ADS)

    Andersen, Jens O.; Brauner, Tomáš; Naylor, William R.

    2015-12-01

    Ab initio numerical simulations of the thermodynamics of dense quark matter remain a challenge. Apart from the infamous sign problem, lattice methods have to deal with finite volume and discretization effects as well as with the necessity to introduce sources for symmetry-breaking order parameters. We study these artifacts in the Polyakov-loop-extended Nambu-Jona-Lasinio (PNJL) model and compare its predictions to existing lattice data for cold and dense two-color matter with two flavors of Wilson quarks. To achieve even qualitative agreement with lattice data requires the introduction of two novel elements in the model: (i) explicit chiral symmetry breaking in the effective contact four-fermion interaction, referred to as the chiral twist, and (ii) renormalization of the Polyakov loop. The feedback of the dense medium to the gauge sector is modeled by a chemical-potential-dependent scale in the Polyakov-loop potential. In contrast to previously used analytical Ansätze, we determine its dependence on the chemical potential from lattice data for the expectation value of the Polyakov loop. Finally, we propose adding a two-derivative operator to our effective model. This term acts as an additional source of explicit chiral symmetry breaking, mimicking an analogous term in the lattice Wilson action.

  17. Organisationsübergreifendes Management von Föderations-Sicherheitsmetadaten auf Basis einer Service-Bus-Architektur

    NASA Astrophysics Data System (ADS)

    Graf, Stephan; Hommel, Wolfgang

    In service-orientierten Architekturen wird die herkömmliche web-service-basierte Punkt-zu-Punkt-Kommunikation zunehmend durch den Einsatz eines Enterprise Service Bus (ESB) abgelöst, der den sicheren und zuverlässigen Nachrichtentransport realisiert. Der Einsatzbereich eines ESB endet jedoch an den Grenzen der ihn einsetzenden Institution. In diesem Artikel analysieren wir aktuelle Herausforderungen bei der organisationsübergreifenden Verwaltung von Sicherheitsmetadaten, zu denen insbesondere Serverzertifikate und Privacy Policies gehören. Als konkretes Szenario wird dabei das Federated Identity Management im Rahmen der deutschen Hochschulföderation DFN-AAI aufgegriffen. Als standardbasierte, einheitliche Lösung, die proprietäre sowie metadatentyp-spezifische Ansätze integriert und den damit verbundenen Administrationsaufwand reduziert, schlagen wir einen organisationsübergreifenden ESB vor, den wir als Federation Service Bus (FedSB) bezeichnen. Wir diskutieren seine technischen Eigenschaften, das zugrunde liegende Kommunikationsmodell und die organisatorischen Schritte zur Einführung.

  18. Phänomenologische Grundlagen der Wärmelehre

    NASA Astrophysics Data System (ADS)

    Heintze, Joachim

    Die Physik der Wärme lässt sich auf zweierlei Weise formulieren: Einmal als Mechanik eines Systems, das eine enorm große Zahl von Teilchen enthält (statistische Mechanik), und einmal mit Hilfe von ad hoc eingeführten Größen, den sogenannten Zustandsgrößen, die geeignet sind, das Verhalten eines solchen Systems zu beschreiben, ohne dass man die Teilchen selbst und ihre Bewegungen betrachten muss (Thermodynamik). Wir werden beide Ansätze in ihrer einfachsten und anschaulichsten Ausprägung in Kap. 5 (kinetische Gastheorie) bzw. in Kap. 8 (Grundbegriffe der Thermodynamik) behandeln. Obgleich sich die volle Durchführung des Programms als begrifflich und mathematisch recht schwierig erweist - die Vorlesung "Thermodynamik und Statistik" steht gewöhnlich am Ende der Kursvorlesungen über theoretische Physik - werden wir doch auf der Grundlage der Kap. 5 und 8 eine Menge über die Physik der Wärme lernen können. Den Ausgangspunkt der Wärmelehre bilden jedoch allemal die Naturerscheinungen, die wir hier in Kap. 4 behandeln wollen: Wärme, Kälte, Temperaturausgleich. Wir werden untersuchen, wie man diese Begriffe quantifizieren kann, und was bei der Erwärmung oder Abkühlung eines Körpers vor sich geht. Dabei werden wir auf den I. und II. Hauptsatz der Wärmelehre stoßen.

  19. Bianchi type-II models in the presence of perfect fluid and anisotropic dark energy

    NASA Astrophysics Data System (ADS)

    Kumar, Suresh; Akarsu, Özgür

    2012-06-01

    The spatially homogeneous but totally anisotropic and non-flat Bianchi type-II cosmological model has been studied in general relativity in the presence of two minimally interacting fluids; a perfect fluid as the matter fluid and a hypothetical anisotropic fluid as the dark energy fluid. The Einstein field equations have been solved by applying two kinematical Ansätze: we have assumed the variation law for the mean Hubble parameter that yields a constant value of the deceleration parameter, and one of the components of the shear tensor has been considered proportional to the mean Hubble parameter. We have particularly dwelled on the accelerating models with non-divergent expansion anisotropy as the Universe evolves. Yielding the anisotropic pressure, the fluid we consider in the context of dark energy can produce results that can be produced in the presence of isotropic fluid in accordance with the ΛCDM cosmology. However, the derived model gives additional opportunities by being able to allow kinematics that cannot be produced in the presence of fluids that yield only isotropic pressure. We have obtained well-behaving cases where the anisotropy of the expansion and the anisotropy of the fluid converge to finite values (include zero) in the late Universe. We have also showed that, although the metric we consider is totally anisotropic, the anisotropy of the dark energy is constrained to be axially symmetric, as long as the overall energy momentum tensor possesses zero shear stress.

  20. Faster identification of optimal contraction sequences for tensor networks

    NASA Astrophysics Data System (ADS)

    Pfeifer, Robert N. C.; Haegeman, Jutho; Verstraete, Frank

    2014-09-01

    The efficient evaluation of tensor expressions involving sums over multiple indices is of significant importance to many fields of research, including quantum many-body physics, loop quantum gravity, and quantum chemistry. The computational cost of evaluating an expression may depend strongly on the order in which the index sums are evaluated, and determination of the operation-minimizing contraction sequence for a single tensor network (single term, in quantum chemistry) is known to be NP-hard. The current preferred solution is an exhaustive search, using either an iterative depth-first approach with pruning or dynamic programming and memoization, but these approaches are impractical for many of the larger tensor network ansätze encountered in quantum many-body physics. We present a modified search algorithm with enhanced pruning which exhibits a performance increase of several orders of magnitude while still guaranteeing identification of an optimal operation-minimizing contraction sequence for a single tensor network. A reference implementation for matlab, compatible with the ncon() and multienv() network contractors of arXiv:1402.0939 and Evenbly and Pfeifer, Phys. Rev. B 89, 245118 (2014),10.1103/PhysRevB.89.245118, respectively, is supplied.

  1. The Kondo problem. II. Crossover from asymptotic freedom to infrared slavery

    NASA Astrophysics Data System (ADS)

    Schlottmann, P.

    1982-04-01

    In the preceding paper we transformed the s-d Hamiltonian onto a resonance level with a large perturbation and derived the scaling equations for the vertices, the invariant coupling, and the resonance width. The scaling equations are integrated under the assumption that the energy dependence of the resonance width can be neglected. The transcendental equation obtained in this way for the renormalized resonance width is solved in the relevant limits and allows a calculation of the static and dynamical susceptibility. At high temperatures the perturbation expansion for the relaxation rate and the susceptibility is reproduced up to third order in Jρ. At low temperatures the lifetime and χ0 remain finite and vary according to a Fermi-liquid theory. The approximation scheme interpolates in this way between the asymptotic freedom and the infrared slavery, yielding a smooth crossover. The present results are in quantitative agreement with previous ones obtained with the relaxation-kernel method by Götze and Schlottmann. The advantages and drawbacks of the method are discussed. The calculation of the dynamical susceptibility is extended to nonzero external magnetic fields. The quasielastic peak of χ''(ω)ω is suppressed at low temperatures and large magnetic fields and shoulders develop at ω=+/-B.

  2. Hilbert space renormalization for the many-electron problem.

    PubMed

    Li, Zhendong; Chan, Garnet Kin-Lic

    2016-02-28

    Renormalization is a powerful concept in the many-body problem. Inspired by the highly successful density matrix renormalization group (DMRG) algorithm, and the quantum chemical graphical representation of configuration space, we introduce a new theoretical tool: Hilbert space renormalization, to describe many-electron correlations. While in DMRG, the many-body states in nested Fock subspaces are successively renormalized, in Hilbert space renormalization, many-body states in nested Hilbert subspaces undergo renormalization. This provides a new way to classify and combine configurations. The underlying wavefunction Ansatz, namely, the Hilbert space matrix product state (HS-MPS), has a very rich and flexible mathematical structure. It provides low-rank tensor approximations to any configuration interaction (CI) space through restricting either the "physical indices" or the coupling rules in the HS-MPS. Alternatively, simply truncating the "virtual dimension" of the HS-MPS leads to a family of size-extensive wave function Ansätze that can be used efficiently in variational calculations. We make formal and numerical comparisons between the HS-MPS, the traditional Fock-space MPS used in DMRG, and traditional CI approximations. The analysis and results shed light on fundamental aspects of the efficient representation of many-electron wavefunctions through the renormalization of many-body states. PMID:26931677

  3. On the semiclassical approach to quantum cosmology: relational particle model

    NASA Astrophysics Data System (ADS)

    Anderson, Edward

    2011-09-01

    The emergent semiclassical time approach to resolving the problem of time in quantum gravity involves heavy slow degrees of freedom providing via an approximately Hamilton-Jacobi equation an approximate time standard with respect to which the quantum mechanics of light fast degrees of freedom can run. More concretely, this approach involves Born-Oppenheimer and WKB ansätze and some accompanying approximations. In this paper, I investigate this approach for concrete scaled relational particle mechanics models, i.e. models featuring only relative separations, relative angles and relative times. I consider the heavy-light interaction term in the light quantum equation—necessary for the semiclassical approach to work, first as an emergent-time-dependent perturbation of the emergent-time-dependent Schrödinger equation for the light subsystem. Secondly, I consider a scheme in which the backreaction is small but non-negligible, so that the l-subsystem also affects the form of the emergent time. I also suggest that the many terms involving expectation values of the light wavefunctions in both the (unapproximated) heavy and light equations might require treatment in parallel to the Hartree-Fock self-consistent approach rather than merely being discarded; for the moment this paper provides a counterexample to such terms being smaller than their unaveraged counterparts. Investigation of these ideas and methods will give us a more robust understanding of the suggested quantum-cosmological origin of microwave background inhomogeneities and galaxies.

  4. Asymptotic decay of the pair correlation function in molecular fluids: Application to hard rods

    NASA Astrophysics Data System (ADS)

    Savenko, S. V.; Dijkstra, Marjolein

    2005-08-01

    We investigate the asymptotic decay of the total correlation function h(1,2) in molecular fluids. To this end, we expand the angular dependence of h(1,2) and the direct correlation function c(1,2) in the Ornstein-Zernike equation in a complete set of rotational invariants. We show that all the harmonic expansion coefficients hl1l2l(r) are governed by a common exponential decay length and a common wavelength of oscillations in the isotropic phase. We determine the asymptotic decay of the total correlation functions by investigating the pole structure of the reciprocal ( q -space) harmonic expansion coefficients hl1l2l(q) . The expansion coefficients in laboratory frame of reference hl1l2l(r) are calculated in computer simulations for an isotropic fluid of hard spherocylinders. We find that the asymptotic decay of h(1,2) is exponentially damped oscillatory for hard spherocylinders with a length-to-diameter ratio L/D⩽10 for all statepoints in the isotropic fluid phase. We compare our results on the pole structure using different theoretical Ansätze for c(1,2) for hard ellipsoids. The theoretical results show that the asymptotic decay of h(1,2) is exponentially damped oscillatory for all elongations of the ellipsoids.

  5. Herschel und die Zukunft der Fern-Infrarot-Astronomie

    NASA Astrophysics Data System (ADS)

    Linz, Hendrik

    2015-06-01

    Schon lange ist die beobachtende Astronomie den engen Grenzen des optisch Sichbaren entwachsen und hat fast alle Bereiche des elektromagnetischen Spektrums für sich dienstbar gemacht. Im sogenannten nahen und mittleren Infrarot (Wellenlängen zwischen 1-30 μm) sowie im Millimeter- und Radio-Regime (Wellenlängen zwischen 1 mm und 10 m) ist die Erdatmosphäre relativ gut durchlässig für elektromagnetische Signale oder hat zumindest eine Vielzahl von spektral begrenzten Transmissionsfenstern, die astronomische Beobachtungen zumindest von höheren Bergen aus möglich machen. Allerdings ist das sogenannte Ferne Infrarot (FIR, 30-300 μm Wellenlänge) von der Erde aus fast völlig unzugänglich für astronomische Beobachtungen. Selbst für die besten Beobachtungsplätze der Erde bleibt die atmosphärische Transmission durch die immense Wasserdampf- Absorption auf ein absolutes Minimum beschränkt. Jedoch erlaubt uns das FIR Zugang zu Informationen, die sehr nützlich sind für die astrophysikalische Forschung und komplementär zu anderen Wellenlängen-Bereichen.

  6. Two methods for restricted configuration spaces within the multiconfiguration time-dependent Hartree-Fock method

    NASA Astrophysics Data System (ADS)

    Haxton, Daniel J.; McCurdy, C. William

    2015-01-01

    The multiconfiguration time-dependent Hartree-Fock (MCTDHF) method has shown promise in calculating electronic dynamics in molecules driven by strong and high-energy lasers. It must incorporate restricted configuration spaces (meaning that a particular combination of Slater determinants is used, instead of full configuration interaction) to be applied to big systems. Two different Ansätze are used to determine the essential term in the equations. The first Ansatz is the Lagrangian variational principle. The explicit, complete MCTDHF equations of motion, satisfying that principle, for arbitrary configuration spaces, are given. The property that a restricted configuration list must satisfy in order for the Lagrangian and McLachlan variational principles to give different results is identified. The second Ansatz keeps the density matrix block diagonal among equivalent orbitals, in a generalization of the method of Worth [J. Chem. Phys. 112, 8322 (2000), 10.1063/1.481438]. The methods perform well in calculating the dynamics of Be and BC2 + subject to ultrafast, ultrastrong lasers in severely truncated Hilbert spaces, although they exhibit differing degrees of numerical stability as implemented.

  7. Faster identification of optimal contraction sequences for tensor networks.

    PubMed

    Pfeifer, Robert N C; Haegeman, Jutho; Verstraete, Frank

    2014-09-01

    The efficient evaluation of tensor expressions involving sums over multiple indices is of significant importance to many fields of research, including quantum many-body physics, loop quantum gravity, and quantum chemistry. The computational cost of evaluating an expression may depend strongly on the order in which the index sums are evaluated, and determination of the operation-minimizing contraction sequence for a single tensor network (single term, in quantum chemistry) is known to be NP-hard. The current preferred solution is an exhaustive search, using either an iterative depth-first approach with pruning or dynamic programming and memoization, but these approaches are impractical for many of the larger tensor network ansätze encountered in quantum many-body physics. We present a modified search algorithm with enhanced pruning which exhibits a performance increase of several orders of magnitude while still guaranteeing identification of an optimal operation-minimizing contraction sequence for a single tensor network. A reference implementation for matlab, compatible with the ncon() and multienv() network contractors of arXiv:1402.0939 and Evenbly and Pfeifer, Phys. Rev. B 89, 245118 (2014), respectively, is supplied. PMID:25314572

  8. Design of a Four Degree_of_Freedom Manipulator for Northern Light Mars Mission

    NASA Astrophysics Data System (ADS)

    Lee, Regina; Quine, Brendan; Sathiyanathan, Kartheephan; Roberts, Caroline

    Northern Light is a Canadian mission to Mars, currently developed by a team of engineers, scientists and industrial organizations. The mission objectives include scientific goals such as the search for life and water, preparation for a sample return and engineering goals including the demonstration of interplanetary travel, an entry, descent and landing system, a rover design, a manipulator/drilling system, and semi-autonomous control in remote operations. The Northern Light team at York University is developing a four degree-of-freedom manipulator system, specifically for this remote operation. The Northern Light manipulator system will be mounted directly on the lander (not on the rover), providing an opportunity to perform scientific missions directly from the lander. The drilling instrument, to be mounted on the manipulator, is currently under development by Dr. Tze Chuen Ng now with the help of Hong Kong's Polytechnics University. The operation concept is based on a “single command cycle” approach. The operation plans are designed to handle exceptions, failures and unforeseen events using local intelligence and a contingency planner.

  9. Varying constants quantum cosmology

    SciTech Connect

    Leszczyńska, Katarzyna; Balcerzak, Adam; Dabrowski, Mariusz P. E-mail: abalcerz@wmf.univ.szczecin.pl

    2015-02-01

    We discuss minisuperspace models within the framework of varying physical constants theories including Λ-term. In particular, we consider the varying speed of light (VSL) theory and varying gravitational constant theory (VG) using the specific ansätze for the variability of constants: c(a) = c{sub 0} a{sup n} and G(a)=G{sub 0} a{sup q}. We find that most of the varying c and G minisuperspace potentials are of the tunneling type which allows to use WKB approximation of quantum mechanics. Using this method we show that the probability of tunneling of the universe ''from nothing'' (a=0) to a Friedmann geometry with the scale factor a{sub t} is large for growing c models and is strongly suppressed for diminishing c models. As for G varying, the probability of tunneling is large for G diminishing, while it is small for G increasing. In general, both varying c and G change the probability of tunneling in comparison to the standard matter content (cosmological term, dust, radiation) universe models.

  10. Decontamination of chemical and biological warfare (CBW) agents using an atmospheric pressure plasma jet (APPJ)

    NASA Astrophysics Data System (ADS)

    Herrmann, H. W.; Henins, I.; Park, J.; Selwyn, G. S.

    1999-05-01

    The atmospheric pressure plasma jet (APPJ) [A. Schütze et al., IEEE Trans. Plasma Sci. 26, 1685 (1998)] is a nonthermal, high pressure, uniform glow plasma discharge that produces a high velocity effluent stream of highly reactive chemical species. The discharge operates on a feedstock gas (e.g., He/O2/H2O), which flows between an outer, grounded, cylindrical electrode and an inner, coaxial electrode powered at 13.56 MHz rf. While passing through the plasma, the feedgas becomes excited, dissociated or ionized by electron impact. Once the gas exits the discharge volume, ions and electrons are rapidly lost by recombination, but the fast-flowing effluent still contains neutral metastable species (e.g., O2*, He*) and radicals (e.g., O, OH). This reactive effluent has been shown to be an effective neutralizer of surrogates for anthrax spores and mustard blister agent. Unlike conventional wet decontamination methods, the plasma effluent does not cause corrosion and it does not destroy wiring, electronics, or most plastics, making it highly suitable for decontamination of sensitive equipment and interior spaces. Furthermore, the reactive species in the effluent rapidly degrade into harmless products leaving no lingering residue or harmful by-products.

  11. Nucleon electromagnetic form factors in two-flavor QCD

    NASA Astrophysics Data System (ADS)

    Capitani, S.; Della Morte, M.; Djukanovic, D.; von Hippel, G.; Hua, J.; Jäger, B.; Knippschild, B.; Meyer, H. B.; Rae, T. D.; Wittig, H.

    2015-09-01

    We present results for the nucleon electromagnetic form factors, including the momentum transfer dependence and derived quantities (charge radii and magnetic moment). The analysis is performed using O (a ) improved Wilson fermions in Nf=2 QCD measured on the Coordinated Lattice Simulations ensembles. Particular focus is placed on a systematic evaluation of the influence of excited states in three-point correlation functions, which lead to a biased evaluation, if not accounted for correctly. We argue that the use of summed operator insertions and fit Ansätze including excited states allow us to suppress and control this effect. We employ a novel method to perform joint chiral and continuum extrapolations, by fitting the form factors directly to the expressions of covariant baryonic chiral effective field theory. The final results for the charge radii and magnetic moment from our lattice calculations include, for the first time, a full error budget. We find that our estimates are compatible with experimental results within their overall uncertainties.

  12. Effective field theory of dark energy: a dynamical analysis

    SciTech Connect

    Frusciante, Noemi; Raveri, Marco; Silvestri, Alessandra E-mail: mraveri@sissa.it

    2014-02-01

    The effective field theory (EFT) of dark energy relies on three functions of time to describe the dynamics of background cosmology. The viability of these functions is investigated here by means of a thorough dynamical analysis. While the system is underdetermined, and one can always find a set of functions reproducing any expansion history, we are able to determine general compatibility conditions for these functions by requiring a viable background cosmology. In particular, we identify a set of variables that allows us to transform the non-autonomous system of equations into an infinite-dimensional one characterized by a significant recursive structure. We then analyze several autonomous sub-systems, obtained truncating the original one at increasingly higher dimension, that correspond to increasingly general models of dark energy and modified gravity. Furthermore, we exploit the recursive nature of the system to draw some general conclusions on the different cosmologies that can be recovered within the EFT formalism and the corresponding compatibility requirements for the EFT functions. The machinery that we set up serves different purposes. It offers a general scheme for performing dynamical analysis of dark energy and modified gravity models within the model independent framework of EFT; the general results, obtained with this technique, can be projected into specific models, as we show in one example. It also can be used to determine appropriate ansätze for the three EFT background functions when studying the dynamics of cosmological perturbations in the context of large scale structure tests of gravity.

  13. Generalization of the Hartree-Fock approach to collision processes

    SciTech Connect

    Hahn, Y.

    1997-06-01

    The conventional Hartree and Hartree-Fock approaches for bound states are generalized to treat atomic collision processes. All the single-particle orbitals, for both bound and scattering states, are determined simultaneously by requiring full self-consistency. This generalization is achieved by introducing two {ital Ans{umlt a}tze}: (a) the weak asymptotic boundary condition, which maintains the correct scattering energy and target orbitals with correct number of nodes, and (b) square integrable amputated scattering functions to generate self-consistent field (SCF) potentials for the target orbitals. The exact initial target and final-state asymptotic wave functions are not required and thus need not be specified {ital a priori}, as they are determined simultaneously by the SCF iterations. To check the asymptotic behavior of the solution, the theory is applied to elastic electron-hydrogen scattering at low energies. The solution is found to be stable and the weak asymptotic condition is sufficient to produce the correct scattering amplitudes. The SCF potential for the target orbital shows the strong penetration by the projectile electron during the collision, but the exchange term tends to restore the original form. Potential applicabilities of this extension are discussed, including the treatment of ionization and shake-off processes. {copyright} {ital 1997} {ital The American Physical Society}

  14. Delocalized Davydov D1 Ansatz for the Holstein polaron

    NASA Astrophysics Data System (ADS)

    Sun, Jin; Duan, Liwei; Zhao, Yang

    2013-05-01

    An efficient, yet very accurate trial wave function, constructed from projecting the well-known Davydov D1 Ansatz onto momentum eigenstates, is employed to study the ground state properties of the generalized Holstein Hamiltonian with simultaneous diagonal and off-diagonal coupling. Ground-state energies have been obtained with a precision matching that of the computationally much more demanding density-matrix renormalization group method. The delocalized D1 Ansatz lowers the ground-state energies at the Brillouin zone boundary significantly compared with the Toyozawa and Global-Local Ansätze in the weak coupling regime, while considerable improvement is demonstrated to have been achieved over the entire Brillouin zone in the strong coupling regime. Unique solutions are obtained with the delocalized D1 for different initial conditions when the transfer integral is 20 times the phonon frequency at the zone center, implying the absence of any self-trapping discontinuity. The scaled correlation variance is found to fit satisfactorily well with the predictions of the perturbation theories.

  15. Decontamination of chemical and biological warfare (CBW) agents using an atmospheric pressure plasma jet (APPJ)

    SciTech Connect

    Herrmann, H.W.; Henins, I.; Park, J.; Selwyn, G.S.

    1999-05-01

    The atmospheric pressure plasma jet (APPJ) [A. Sch{umlt u}tze {ital et al.}, IEEE Trans. Plasma Sci. {bold 26}, 1685 (1998)] is a nonthermal, high pressure, uniform glow plasma discharge that produces a high velocity effluent stream of highly reactive chemical species. The discharge operates on a feedstock gas (e.g., He/O{sub 2}/H{sub 2}O), which flows between an outer, grounded, cylindrical electrode and an inner, coaxial electrode powered at 13.56 MHz rf. While passing through the plasma, the feedgas becomes excited, dissociated or ionized by electron impact. Once the gas exits the discharge volume, ions and electrons are rapidly lost by recombination, but the fast-flowing effluent still contains neutral metastable species (e.g., O{sub 2}{sup {asterisk}}, He{sup {asterisk}}) and radicals (e.g., O, OH). This reactive effluent has been shown to be an effective neutralizer of surrogates for anthrax spores and mustard blister agent. Unlike conventional wet decontamination methods, the plasma effluent does not cause corrosion and it does not destroy wiring, electronics, or most plastics, making it highly suitable for decontamination of sensitive equipment and interior spaces. Furthermore, the reactive species in the effluent rapidly degrade into harmless products leaving no lingering residue or harmful by-products. {copyright} {ital 1999 American Institute of Physics.}

  16. Engineering the just war: examination of an approach to teaching engineering ethics.

    PubMed

    Haws, David R

    2006-04-01

    The efficiency of engineering applied to civilian projects sometimes threatens to run away with the social agenda, but in military applications, engineering often adds a devastating sleekness to the inevitable destruction of life. The relative crudeness of terrorism (e.g., 9/11) leaves a stark after-image, which belies the comparative insignificance of random (as opposed to orchestrated) belligerence. Just as engineering dwarfs the bricolage of vernacular design 'moving us past the appreciation of brush-strokes, so to speak' the scale of engineered destruction makes it difficult to focus on the charred remains of individual lives. Engineers need to guard against the inappropriate military subsumption of their effort. Fortunately, the ethics of warfare has been an ongoing topic of discussion for millennia. This paper will examine the university core class I've developed (The Moral Dimensions of Technology) to meet accreditation requirements in engineering ethics, and the discussion with engineering and non-engineering students focused by the life of electrical engineer Vannevar Bush, with selected readings in moral philosophy from the Dao de Jing, Lao Tze, Cicero, Aurelius Augustinus, Kant, Annette Baier, Peter Singer, Elizabeth Anscombe, Philippa Foot, and Judith Thomson. PMID:16609723

  17. Hilbert space renormalization for the many-electron problem

    NASA Astrophysics Data System (ADS)

    Li, Zhendong; Chan, Garnet Kin-Lic

    2016-02-01

    Renormalization is a powerful concept in the many-body problem. Inspired by the highly successful density matrix renormalization group (DMRG) algorithm, and the quantum chemical graphical representation of configuration space, we introduce a new theoretical tool: Hilbert space renormalization, to describe many-electron correlations. While in DMRG, the many-body states in nested Fock subspaces are successively renormalized, in Hilbert space renormalization, many-body states in nested Hilbert subspaces undergo renormalization. This provides a new way to classify and combine configurations. The underlying wavefunction Ansatz, namely, the Hilbert space matrix product state (HS-MPS), has a very rich and flexible mathematical structure. It provides low-rank tensor approximations to any configuration interaction (CI) space through restricting either the "physical indices" or the coupling rules in the HS-MPS. Alternatively, simply truncating the "virtual dimension" of the HS-MPS leads to a family of size-extensive wave function Ansätze that can be used efficiently in variational calculations. We make formal and numerical comparisons between the HS-MPS, the traditional Fock-space MPS used in DMRG, and traditional CI approximations. The analysis and results shed light on fundamental aspects of the efficient representation of many-electron wavefunctions through the renormalization of many-body states.

  18. Self-consistent approach to the description of relaxation processes in classical multiparticle systems

    NASA Astrophysics Data System (ADS)

    Mokshin, A. V.

    2015-04-01

    The concept of time correlation functions is a very convenient theoretical tool in describing relaxation processes in multiparticle systems because, on one hand, correlation functions are directly related to experimentally measured quantities (for example, intensities in spectroscopic studies and kinetic coefficients via the Kubo-Green relation) and, on the other hand, the concept is also applicable beyond the equilibrium case. We show that the formalism of memory functions and the method of recurrence relations allow formulating a self-consistent approach for describing relaxation processes in classical multiparticle systems without needing a priori approximations of time correlation functions by model dependences and with the satisfaction of sum rules and other physical conditions guaranteed. We also demonstrate that the approach can be used to treat the simplest relaxation scenarios and to develop microscopic theories of transport phenomena in liquids, the propagation of density fluctuations in equilibrium simple liquids, and structure relaxation in supercooled liquids. This approach generalizes the mode-coupling approximation in the Götze-Leutheusser realization and the Yulmetyev-Shurygin correlation approximations.

  19. Pulse-like rupture induced by three-dimensional fault zone flower structures

    NASA Astrophysics Data System (ADS)

    Pelties, Christian; Huang, Yihe; Ampuero, Jean-Paul

    2013-04-01

    Mature faults are often embedded in low-velocity fault zones (LVFZs). Numerical simulations of dynamic rupture including a LVFZ by Huang and Ampuero (2011) showed that if the wave velocity contrast between the LVFZ and the country rock is strong enough, ruptures can behave as pulse-like ruptures. The healing front that stops the rupture is generated by reflected waves from the LVFZ-country rock interface. However, the numerical study by Huang and Ampuero (2011) was limited to two-dimensional problems with fault-parallel fault zone structures. Natural fault zones include complexities such as flower structures with depth-dependent velocity and thickness, and limited depth extent. We will show here that the mechanism of pulse generation induced by the LVFZ also operates efficiently in such three-dimensional fault zone structures. This investigation requires high resolution and flexible mesh generation, which are enabled here by the high-order accurate ADER-DG method with an unstructured tetrahedral element discretization (Pelties et al., 2012). Our simulations show that the pulse generation mechanism is robust to the depth extent of the LVFZ and to the position of the hypocenter (whether it is inside or below the LVFZ). In particular, for events with hypocenter deeper than a shallow LVFZ, we find that a healing front emerges soon after the rupture enters the LVFZ, with rise time controlled by the LVFZ properties. Moreover, this healing front reflects from the free surface and propagates downdip beyond the bottom of the LVFZ, inducing there pulse-like rupture with longer rise time. Thus, we find that the depth-dependence of rise time might reflect the depth extent of the LVFZ. References: Huang, Y. and J.-P. Ampuero (2011), Pulse-like ruptures induced by low-velocity fault zones, J. Geophys. Res., 116, B12307, doi:10.1029/2011JB008684. Pelties, C., J. de la Puente, J.-Pl Ampuero, G. B. Brietzke, and M. Käser (2012), Three-Dimensional Dynamic Rupture Simulation with a High-order Discontinuous Galerkin Method on Unstructured Tetrahedral Meshes, J. Geophys. Res., 117, B02309, doi:10.1029/2011JB008857.

  20. Taylor-plasticity-based analysis of length scale effects in void growth

    NASA Astrophysics Data System (ADS)

    Liu, J. X.; Demiral, M.; El Sayed, T.

    2014-10-01

    We have studied the void growth problem by employing the Taylor-based strain gradient plasticity theories, from which we have chosen the following three, namely, the mechanism-based strain gradient (MSG) plasticity (Gao et al 1999 J. Mech. Phys. Solids 47 1239, Huang et al 2000 J. Mech. Phys. Solids 48 99-128), the Taylor-based nonlocal theory (TNT; 2001 Gao and Huang 2001 Int. J. Solids Struct. 38 2615) and the conventional theory of MSG (CMSG; Huang et al 2004 Int. J. Plast. 20 753). We have addressed the following three issues which occur when plastic deformation at the void surface is unconstrained. (1) Effects of elastic deformation. Elasticity is essential for cavitation instability. It is therefore important to guarantee that the gradient term entering the Taylor model is the effective plastic strain gradient instead of the total strain gradient. We propose a simple elastic-plastic decomposition method. When the void size approaches the minimum allowable initial void size related to the maximum allowable geometrically necessary dislocation density, overestimation of the flow stress due to the negligence of the elastic strain gradient is on the order of \\frac{l\\varepsilon_Y}{R0} near the void surface, where l, ɛY and R0 are, respectively, the intrinsic material length scale, the yield strain and the initial void radius. (2) MSG intrinsic inconsistency, which was initially mentioned in Gao et al (1999 J. Mech. Phys. Solids 47 1239) but has not been the topic of follow-up studies. We realize that MSG higher-order stress arises due to the linear-strain-field approximation within the mesoscale cell with a nonzero size, lɛ. Simple analysis shows that within an MSG mesoscale cell near the void surface, the difference between microscale and mesoscale strains is on the order of (\\frac{l\\varepsilon}{R0})2 , indicating that when \\frac{l\\varepsilon}{R0}˜ 1.0 , the higher-order stress effect can make the MSG result considerably different from the TNT or CMSG results. (3) Critical condition for cavitation instability. When Taylor plasticity replaces classical plasticity as the flow rule, the critical cavitation condition, appearing when the derivative of the externally imposed mean stress with respect to the current void radius becomes zero, is rewritten analytically according to the Leibniz relation and found to be very different from the classical counterpart.

  1. Validation of two energy balance closure parameterisations using field measurements

    NASA Astrophysics Data System (ADS)

    Eder, Fabian; De Roo, Frederik; Kohnert, Katrin; Desjardins, Raymond L.; Foken, Thomas; Schmid, Hans Peter; Mauder, Matthias

    2013-04-01

    Eddy Covariance (EC) measurements often do not close the energy balance. This indicates that surface heat fluxes are underestimated, likely because large-scale eddies and stationary circulations are not captured. Because EC is a widespread tool in environmental science to assess energy fluxes and trace gas budgets, it is essential to quantify the 'missing' fluxes. In the literature, two approaches to parameterise the lack of energy balance closure can be found. The first one by Huang et al (2008) is based on large-eddy simulations (LES) and perceives the energy imbalance as being the result of large-scale turbulent organized structures. The second approach by Panin and Bernhofer (2008) suggests an empirical approach which focuses on surface roughness heterogeneities on the landscape-scale. We tested both approaches with EC data from three sites, located in southern Germany, of the Terrestrial Environmental Observatories (TERENO) programme. Additionally, we applied the parameterisations to aircraft data from Canada, which were conducted as part of the Boreal Ecosystem-Atmosphere Study (BOREAS) experiment and the Boreal Ecosystem Research and Monitoring Sites (BERMS) programme. For each flight, the flux contribution of turbulent structures larger than 2 km, determined by wavelet analysis, serves as an estimate of the missing flux of conventional EC measurements. In most cases, the two parameterisations do not give a reliable prediction of the energy balance residual. The approach of Panin and Bernhofer (2008) disregards topographical effects, differences in surface moisture and surface temperature and thus, it cannot explain the poor energy balance closure of the TERENO sites. However, above the flat terrain of the airborne measurements in Canada, it works surprisingly well. The parameterisation by Huang et al (2008) was developed for homogeneous terrain, a condition which is almost never met in field studies. In addition, there is a general mismatch between LES and tower-based measurements: the simulations almost close the energy balance near the surface, presumably due to the too coarse grid resolution. Therefore, this parameterisation is not really applicable to typical flux measurements in heterogeneous landscapes that are usually conducted in the surface layer. References: Huang J, Lee X, Patton E (2008) A modelling study of flux imbalance and the influence of entrainment in the convective boundary layer. Boundary Layer Meteorol 127:273-292. Panin GN, Bernhofer Ch (2008) Parametrization of turbulent fluxes over inhomogeneous landscapes. Izvestiya Atmos Oceanic Phys 44:701-716.

  2. Theory of exciton transfer and diffusion in conjugated polymers

    SciTech Connect

    Barford, William; Tozer, Oliver Robert

    2014-10-28

    We describe a theory of Förster-type exciton transfer between conjugated polymers. The theory is built on three assumptions. First, we assume that the low-lying excited states of conjugated polymers are Frenkel excitons coupled to local normal modes, and described by the Frenkel-Holstein model. Second, we assume that the relevant parameter regime is ℏω < J, i.e., the adiabatic regime, and thus the Born-Oppenheimer factorization of the electronic and nuclear degrees of freedom is generally applicable. Finally, we assume that the Condon approximation is valid, i.e., the exciton-polaron wavefunction is essentially independent of the normal modes. The resulting expression for the exciton transfer rate has a familiar form, being a function of the exciton transfer integral and the effective Franck-Condon factors. The effective Franck-Condon factors are functions of the effective Huang-Rhys parameters, which are inversely proportional to the chromophore size. The Born-Oppenheimer expressions were checked against DMRG calculations, and are found to be within 10% of the exact value for a tiny fraction of the computational cost. This theory of exciton transfer is then applied to model exciton migration in conformationally disordered poly(p-phenylene vinylene). Key to this modeling is the assumption that the donor and acceptor chromophores are defined by local exciton ground states (LEGSs). Since LEGSs are readily determined by the exciton center-of-mass wavefunction, this theory provides a quantitative link between polymer conformation and exciton migration. Our Monte Carlo simulations indicate that the exciton diffusion length depends weakly on the conformation of the polymer, with the diffusion length increasing slightly as the chromophores became straighter and longer. This is largely a geometrical effect: longer and straighter chromophores extend over larger distances. The calculated diffusion lengths of ∼10 nm are in good agreement with experiment. The spectral properties of the migrating excitons are also investigated. The emission intensity ratio of the 0-0 and 0-1 vibronic peaks is related to the effective Huang-Rhys parameter of the emitting state, which in turn is related to the chromophore size. The intensity ratios calculated from the effective Huang-Rhys parameters are in agreement with experimental spectra, and the time-resolved trend for the intensity ratio to decrease with time was also reproduced as the excitation migrates to shorter, lower energy chromophores as a function of time. In addition, the energy of the exciton state shows a logarithmic decrease with time, in agreement with experimental observations.

  3. Aquaporin-1 shifts the critical transmural pressure to compress the aortic intima and change transmural flow: theory and implications.

    PubMed

    Joshi, Shripad; Jan, Kung-Ming; Rumschitzki, David S

    2015-12-01

    Transmural-pressure (ΔP)-driven plasma advection carries macromolecules into the vessel wall, the earliest prelesion atherosclerotic event. The wall's hydraulic conductivity, LP, the water flux-to-ΔP ratio, is high at low pressures, rapidly decreases, and remains flat to high pressures (Baldwin AL, Wilson LM. Am J Physiol Heart Circ Physiol 264: H26-H32, 1993; Nguyen T, Toussaint, Xue JD, Raval Y, Cancel CB, Russell LM, Shou S, Sedes Y, Sun O, Yakobov Y, Tarbell JM, Jan KM, Rumschitzki DS. Am J Physiol Heart Circ Physiol 308: H1051-H1064, 2015; Tedgui A, Lever MJ. Am J Physiol Heart Circ Physiol. 247: H784-H791, 1984. Shou Y, Jan KM, Rumschitzki DS. Am J Physiol Heart Circ Physiol 291: H2758-H2771, 2006) due to pressure-induced subendothelial intima (SI) compression that causes endothelial cells to partially block internal elastic laminar fenestrae. Nguyen et al. showed that rat and bovine aortic endothelial cells express the membrane protein aquaporin-1 (AQP1) and transmural water transport is both transcellular and paracellular. They found that LP lowering by AQP1 blocking was perplexingly ΔP dependent. We hypothesize that AQP1 blocking lowers average SI pressure; therefore, a lower ΔP achieves the critical force/area on the endothelium to partially block fenestrae. To test this hypothesis, we improve the approximate model of Huang et al. (Huang Y, Rumschitzki D, Chien S, Weinbaum SS. Am J Physiol Heart Circ Physiol 272: H2023-H2039, 1997) and extend it by including transcellular AQP1 water flow. Results confirm the observation by Nguyen et al.: wall LP and water transport decrease with AQP1 disabling. The model predicts 1) low-pressure LP experiments correctly; 2) AQP1s contribute 30-40% to both the phenomenological endothelial + SI and intrinsic endothelial LP; 3) the force on the endothelium for partial SI decompression with functioning AQP1s at 60 mmHg equals that on the endothelium at ∼43 mmHg with inactive AQP1s; and 4) increasing endothelial AQP1 expression increases wall LP and shifts the ΔP regime where LP drops to significantly higher ΔP than in Huang et al. Thus AQP1 upregulation (elevated wall LP) might dilute and slow low-density lipoprotein binding to SI extracellular matrix, which may be beneficial for early atherogenesis. PMID:26342066

  4. Discovery of Weyl fermion semimetal and topological Fermi arc quasiparticles in TaAs, NbAs, NbP, TaP and related materials

    NASA Astrophysics Data System (ADS)

    Hasan, M. Zahid

    Topological matter can host Dirac, Majorana and Weyl fermions as quasiparticle modes on their boundaries. First, I briefly mention the basic theoretical concepts defining insulators and superconductors where topological surface state modes are robust only in the presence of a gap (Hasan & Kane; Rev. of Mod. Phys. 82, 3045 (2010)). In these systems topological protection is lost once the gap is closed turning the system into a trivial metal. A Weyl semimetal is the rare exception in this scheme which is a topologically robust metal (semimetal) whose low energy emergent excitations are Weyl fermions. In a Weyl fermion semimetal, the chiralities associated with the Weyl nodes can be understood as topological charges, leading to split monopoles and anti-monopoles of Berry curvature in momentum space. This gives a measure of the topological strength of the system. Due to this topology a Weyl semimetal is expected to exhibit 2D Fermi arc quasiparticles on its surface (Wan et.al., 2011). These arcs (``fractional'' Fermi surfaces) are discontinuous or disjoint segments of a two dimensional Fermi contour, which are terminated onto the projections of the Weyl fermion nodes on the surface we have observed experimentally in TaAs, NbAs, NbP class of materials (Xu, Belopolski et.al., Science 349, 613 (2015); Xu, Alidoust et.al., Nature Phys. (2015); Xu, Belopolski et.al., Science Adv. (2015), Belopolski, Xu et.al., arXiv (2015)) following our theoretical predictions (Huang, Xu, Belopolski et.al., Nature Commun. 6:7373 (2015), submitted in November 2014). Our theoretical predictions (Nature Commun. 2015) and experimental demonstrations (Science 2015, Nature Physics 2015, Science Advances 2015) reveal that these Fermi arc quasiparticles can only live on the boundary of a 3D crystal which collectively represents the realization of a new state of quantum matter beyond our earlier work on Fermi arcs in topological materials (Xu, Liu, Kushwaha et.al., Science 347, 294 (2015), adv.online (2014)). This work is in collaboration with Su-Yang Xu, Ilya Belopolski, Nasser Alidoust, Madhab Neupane, Chenglong Zhang, Raman Sankar, Shin-Ming Huang, Chi-Cheng Lee, Guoqing Chang, BaoKai Wang, Guang Bian, Hao Zheng, Daniel S. Sanchez, Fangcheng Chou, Hsin Lin, Shuang Jia, Titus Neupert. This work is supported by GBMF and U.S. DOE. In collaboration with Su-Yang Xu, I. Belopolski, N. Alidoust, M. Neupane, C. Zhang, R. Sankar, S.-M. Huang, C.-C. Lee, G. Chang, B. Wang, G. Bian, H. Zheng, D. Sanchez, F.-C. Chou, T. Neupert, Hsin Lin, Shuang Jia. Work supported by GBMF(Moore) & DOE.

  5. Vibrational Spectroscopy of Transient Dipolar Radicals via Autodetachment of Dipole-Bound States of Cold Anions

    NASA Astrophysics Data System (ADS)

    Huang, Dao-Ling; Liu, Hong-Tao; Dau, Phuong Diem; Wang, Lai-Sheng

    2014-06-01

    High-resolution vibrational spectroscopy of transient species is important for determining their molecular structures and understanding their chemical reactivity. However, the low abundance and high reactivity of molecular radicals pose major challenges to conventional absorption spectroscopic methods. The observation of dipole-bound states (DBS) in anions extend autodetachment spectroscopy to molecular anions whose corresponding neutral radicals possess a large enough dipole moment (>2.5 D).1,2 However, due to the difficulty of assigning the congested spectra at room temperature, there have been only a limited number of autodetachment spectra via DBS reported. Recently, we have built an improved version of a cold trap3 coupled with high-resolution photoelectron imaging.4 The first observation of mode-specific auotodetachment of DBS of cold phenoxide have shown that not only vibrational hot bands were completely suppressed, but also rotational profile was observed.5 The vibrational frequencies of the DBS were found to be the same as those of the neutral radical, suggesting that vibrational structures of dipolar radicals can be probed via DBS.5 More significantly, the DBS resonances allowed a number of vibrational modes with very weak Frank-Condon factors to be "lightened" up via vibrational autodetachment.5 Recently, our first high-resolution vibrational spectroscopy of the dehydrogenated uracil radical, with partial rotational resolution, via autodetachment from DBS of cold deprotonated uracil anions have been reported.6 Rich vibrational information is obtained for this important radical species. The resolved rotational profiles also allow us to characterize the rotational temperature of the trapped anions for the first time.6 1 K. R. Lykke, D. M. Neumark, T. Andersen, V. J. Trapa, and W. C. Lineberger, J. Chem. Phys. 87, 6842 (1987). 2 D. M. Wetzel, and J. I. Brauman, J. Chem. Phys. 90, 68 (1989). 3 P. D. Dau, H. T. Liu, D. L. Huang, and L. S. Wang, J. Chem. Phys. 137, 116101 (2012). 4 I. Leon, Z. Yang, and L. S. Wang, J. Chem. Phys. 138, 184304 (2013). 5 H. T. Liu, C. G. Ning, D. L. Huang, P. D. Dau, and L. S. Wang, Angew. Chem. Int. Ed. 52, 8976 (2013). 6 H. T. Liu, C. G. Ning, D. L. Huang, and L. S. Wang, Angew. Chem. Int. Ed. (accepted)

  6. Analysis of Ocean Electromagnetic Data Using a Hilbert Spectrum Approach

    NASA Astrophysics Data System (ADS)

    Ridgway, Jeffrey; Larsen, Michael L.; Waldman, Cye H.; Gabbay, Michael; Buntzen, Rodney R.; Rees, C. David

    2003-08-01

    We apply a newly developed time series analysis technique, the Hilbert-Huang Transform (HHT), to naturally occurring ocean electromagnetic data obtained from bottom-mounted sensors. The HHT was originally developed as an alternative to the Fourier power spectral density for the analysis of nonlinear phenomena in water waves. The HHT is applied to the data in two steps. In the first step, an empirical mode decomposition is used to extract individual oscillatory modes possessing different characteristic time scales. Unlike Fourier modes, however, these modes can vary in amplitude and frequency. In the second step, the Hilbert transform is used to determine physically meaningful instantaneous frequencies from these modes. We present results showing that the HHT provides a more compact representation of the ocean electromagnetic environment than the Fourier spectrum. In particular, the HHT is able to capture nonlinear wave phenomena associated with ocean swell in a single mode without the need for higher order harmonics.

  7. A new interpretation of internal-variable theory in finite thermo-viscoelasticity

    NASA Astrophysics Data System (ADS)

    Huang, ZhuPing; Dui, GuanSuo; Yang, ShengYou

    2013-03-01

    Based on the non-equilibrium thermodynamics, an internal- variable theory in thermo-viscoelasticity at finite deformation was proposed by Huang in 1999. In this theory, a modified stretch of the molecular chain was introduced, and hence the molecular network model in rubber elasticity was extended to take into account the viscous and thermal effects of the material. The viscous dissipation of the material can then be described by means of these internal variables, which appear in the expression of the modified stretch. In order to give a clearer explanation on the physical implication of the internal variables, a connection between the internal-variable theory and theoretical formulation based on the multiplicative decomposition of the deformation gradient in existing literature is presented in this paper, which allows the above internal-variable theory to be more systematic.

  8. ELECTROMAGNETISM, OPTICS, ACOUSTICS, HEAT TRANSFER, CLASSICAL MECHANICS, AND FLUID DYNAMICS: Symmetry Analysis of Barotropic Potential Vorticity Equation

    NASA Astrophysics Data System (ADS)

    Bihlo, Alexander; Popovych, Roman O.

    2009-10-01

    Recently F. Huang [Commun. Theor. Phys. 42 (2004) 903] and X. Tang and P.K. Shukla [Commun. Theor. Phys. 49 (2008) 229] investigated symmetry properties of the barotropic potential vorticity equation without forcing and dissipation on the beta-plane. This equation is governed by two dimensionless parameters, F and β, representing the ratio of the characteristic length scale to the Rossby radius of deformation and the variation of earth' angular rotation, respectively. In the present paper it is shown that in the case F ≠ 0 there exists a well-defined point transformation to set β = 0. The classification of one- and two-dimensional Lie subalgebras of the Lie symmetry algebra of the potential vorticity equation is given for the parameter combination F ≠ 0 and β = 0. Based upon this classification, distinct classes of group-invariant solutions are obtained and extended to the case β ≠ 0.

  9. 5d-4f emission of Eu2+ and electron-vibrational interaction in several alkaline earth sulfides doped with Eu2+ and Er3+

    NASA Astrophysics Data System (ADS)

    Kumar, G. A.; Liu, D.-X.; Tian, Y.; Brik, M. G.; Sardar, D. K.

    2015-12-01

    Several alkaline earth sulfides doped with Eu2+ and Er3+ ions have been synthesized and shown to be potential phosphors for applications in the visible spectral range. The excitation and emission spectra corresponding to the 4f-5d interconfigurational transitions of Eu2+ were analyzed with an aim of extraction of the main parameters of the electron-vibrational interaction. The values of the Huang-Rhys factor, effective phonon energies, and zero-phonon line positions were systematically compared for all studied materials; physical trends were discussed. As a test for the validity of the obtained parameters, the Eu2+ 5d-4f emission bands were modeled to yield good agreement with the experimental spectra.

  10. Stability of magic planar Ag clusters

    NASA Astrophysics Data System (ADS)

    Chiu, Y. P.; Ou, Y. S.; Chang, Y. R.; Wei, C. M.; Chang, C. S.; Tsong, Tien T.

    2007-03-01

    The spontaneous assembly of atoms and molecules in a system has attracted many research interests and created numerous potential applications. Utilizing the periodic pattern found on the Pb quantum islands, which are grown on the Si(111) surface, we have recently discovered that self-organized Ag planar clusters formed on these templates exhibit enhanced stability at some particular sizes [1]. Existence of the magic atom numbers in these clusters is mainly attributed to the electronic confinement effect. Here, we further explore the strength of these magic clusters subject to the temperature rise and oxygen exposure. Detailed calculations based on ab initio density functional theory have also been performed. The results help establish the relation between the physical and chemical stability of a magic Ag cluster and its size and shape. Ref:[1] Ya-Ping Chiu, Li-Wei Huang, Ching-Ming Wei, Chia-Seng Chang, and Tien-Tzou Tsong, Phys. Rev. Lett. 97, 165504 (2006).

  11. Complex dynamics of a delayed discrete neural network of two nonidentical neurons

    SciTech Connect

    Chen, Yuanlong; Huang, Tingwen; Huang, Yu

    2014-03-15

    In this paper, we discover that a delayed discrete Hopfield neural network of two nonidentical neurons with self-connections and no self-connections can demonstrate chaotic behaviors. To this end, we first transform the model, by a novel way, into an equivalent system which has some interesting properties. Then, we identify the chaotic invariant set for this system and show that the dynamics of this system within this set is topologically conjugate to the dynamics of the full shift map with two symbols. This confirms chaos in the sense of Devaney. Our main results generalize the relevant results of Huang and Zou [J. Nonlinear Sci. 15, 291303 (2005)], Kaslik and Balint [J. Nonlinear Sci. 18, 415432 (2008)] and Chen et al. [Sci. China Math. 56(9), 18691878 (2013)]. We also give some numeric simulations to verify our theoretical results.

  12. Remote sensing and hydrogeological methodologies for irrigation canal leakage detection: the Osasco and Fossano test sites (NorthWestern Italy)

    NASA Astrophysics Data System (ADS)

    Perotti, Luigi; Clemente, Paolo; De Luca, Domenico Antonio; Dino, Giovanna; Lasagna, Manuela

    2013-04-01

    Seventy percent of global fresh water is usually used for irrigation. This rate is three times the amount of water used by industry and ten times the amount used in domestic and urban environment (Hotchkiss et al., 2001). However, the average efficiency of the water transport for agricultural purposes in different contexts (at world scale) is variable between 30% and 80%. Studies conducted in Italy confirms that rates are similar from the case studies abroad. In this research, satellite image analysis and hydrological-hydrogeological methods were used in two pilot sites (Osasco channel and Fossano channel, in the Noth-Western Italy) to identify the areas most prone to this problem and to quantify the losses. The aim of the study is to define a multidisciplinary approach in order to identify the critical situations of irrigation channels for a sustainable water resource use and management. The use of remote sensing techniques can identify, on a regional scale and at relative low cost, the channels section potentially critical upon which focus the attention and perform in-situ investigation. The presence of leakage from the irrigation canals, indeed, tends to induce variations of moisture on the surface ground. These variations affect the vegetation (e.g. vegetation state), and certain physical characteristics of the soil (e.g. the capacity and thermal conductivity). The analysis of these anomalies, conducted with digital image processing techniques (with infrared spectrum bands particularly sensitive to the above indicators) help to identify those areas with anomalies related to increased losses (Huang and Fipps, 2002). The use of satellite imagery in the proposed approach is an innovative application of Earth Observation for land and water monitoring (Huang et al., 2005). After the identification of anomalies, hydrological-hydrogeological methods were applied to evaluate the losses. At fist an hydrogeological characterisation of the study area and the bottom of the irrigation channel were conducted. Then the canals seepage rates were estimated using inflow-outflow tests and tests with double-tracer, an adaptation from QUEST method (Rieckermann and Gujer, 2002). This approach allowed an experimental calibration and validation of the satellite images analysis. The applied multidisciplinary approach seem to be a promising way for a good general screening for a rapid detection of irrigation channels water losses. References Hotchkiss, R.H., Wingert, C.B., Kelly, W.E., 2001. Determining irrigation canal seepage with electrical resistivity. ASCE J. Irrig. Drain 127, 20-26. Huang Y and Fipps G. (2002). Thermal Imaging of Canals for Remote Detection of Leaks: Evaluation in the United Irrigation District. Technical Report. Biological and Agricultural Engineering Department, Texas A&M University. Huang Y, Fipps G, Maas S, Fletcher R. (2005). Airborne multispectral remote sensing imaging for detecting irrigation canal leaks in the lower rio grande valley - 20th Biennial Workshop on Aerial Photography, Videography, and High Resolution Digital Imagery for Resource Assessment October 4-6, Weslaco, Texas. Rieckermann J., Gujer W. (2002) - Quantifying Exfiltration from Leaky Sewers with Artificial Tracers - Proceedings of the International Conference on "Sewer Operation and Maintenance. 2002", Bradford, UK.

  13. Comprehensive comparisons of geodesic acoustic mode characteristics and dynamics between Tore Supra experiments and gyrokinetic simulations

    SciTech Connect

    Storelli, A. Vermare, L.; Hennequin, P.; Gürcan, Ö. D.; Singh, Rameswar; Morel, P.; Dif-Pradalier, G.; Sarazin, Y.; Garbet, X.; Grandgirard, V.; Ghendrih, P.; Görler, T.

    2015-06-15

    In a dedicated collisionality scan in Tore Supra, the geodesic acoustic mode (GAM) is detected and identified with the Doppler backscattering technique. Observations are compared to the results of a simulation with the gyrokinetic code GYSELA. We found that the GAM frequency in experiments is lower than predicted by simulation and theory. Moreover, the disagreement is higher in the low collisionality scenario. Bursts of non harmonic GAM oscillations have been characterized with filtering techniques, such as the Hilbert-Huang transform. When comparing this dynamical behaviour between experiments and simulation, the probability density function of GAM amplitude and the burst autocorrelation time are found to be remarkably similar. In the simulation, where the radial profile of GAM frequency is continuous, we observed a phenomenon of radial phase mixing of the GAM oscillations, which could influence the burst autocorrelation time.

  14. Two new species of Oobius Trjapitzin (Hymenoptera, Encyrtidae) egg parasitoids of Agrilus spp. (Coleoptera, Buprestidae) from the USA, including a key and taxonomic notes on other congeneric Nearctic taxa

    PubMed Central

    Triapitsyn, Serguei V.; Petrice, Toby R.; Gates, Michael W.; Bauer, Leah S.

    2015-01-01

    Abstract Oobius Trjapitzin (Hymenoptera, Encyrtidae) species are egg parasitoids that are important for the biological control of some Buprestidae and Cerambycidae (Coleoptera). Two species, Oobius agrili Zhang & Huang and Oobius longoi (Siscaro), were introduced into North America for classical biocontrol and have successfully established. Two new native North American species that parasitize eggs of Agrilus spp. (Buprestidae) are described and illustrated from the USA: Oobius minusculus Triapitsyn & Petrice, sp. n. (Michigan), an egg parasitoid of both Agrilus subcinctus Gory on ash (Fraxinus spp.) and Agrilus egenus Gory on black locust (Robinia pseudoacacia L.) trees, and Oobius whiteorum Triapitsyn, sp. n. (Pennsylvania), an egg parasitoid of Agrilus anxius Gory on European white birch (Betula pendula Roth). A taxonomic key and notes on the Nearctic native and introduced Oobius species are also included. PMID:25931963

  15. Timely online chatter detection in end milling process

    NASA Astrophysics Data System (ADS)

    Fu, Yang; Zhang, Yun; Zhou, Huamin; Li, Dequn; Liu, Hongqi; Qiao, Haiyu; Wang, Xiaoqiang

    2016-06-01

    Chatter is one of the most unexpected and uncontrollable phenomenon during the milling operation. It is very important to develop an effective monitoring method to identify the chatter as soon as possible, while existing methods still cannot detect it before the workpiece has been damaged. This paper proposes an energy aggregation characteristic-based Hilbert-Huang transform method for online chatter detection. The measured vibration signal is firstly decomposed into a series of intrinsic mode functions (IMFs) using ensemble empirical mode decomposition. Feature IMFs are then selected according to the majority energy rule. Subsequently Hilbert spectral analysis is applied on these feature IMFs to calculate the Hilbert time/frequency spectrum. Two indicators are proposed to quantify the spectrum and thresholds are automatically calculated using Gaussian mixed model. Milling experiments prove the proposed method to be effective in protecting the workpiece from severe chatter damage within acceptable time complexity.

  16. A numerical study of the motion of a neutrally buoyant cylinder in two dimensional shear flow

    NASA Astrophysics Data System (ADS)

    Pan, Tsorng-Whay; Huang, Shih-Lin; Chen, Shih-Di; Chu, Chin-Chou; Chang, Chien-Cheng

    2012-11-01

    We have investigated the motion of a neutrally buoyant cylinder of circular or elliptic shape in two dimensional shear flow of a Newtonian fluid by direct numerical simulation. The numerical results are validated by comparisons with existing theoretical, experimental and numerical results, including a power law of the normalized angular speed versus the particle Reynolds number. The centerline between two walls is an expected equilibrium position of the cylinder mass center in shear flow. When placing the particle away from the centerline initially, it migrates toward another equilibrium position for higher Reynolds numbers due to the interplay between the slip velocity, the Magnus force, and the wall repulsion force. T-W Pan acknowledges the support by the US NSF and S-L Huang, S-D Chen, C-C Chu, C-C Chang acknowledge the support by the National Science Council of Taiwan, ROC.

  17. Tracking and Recognition of Multiple Human Targets Moving in a Wireless Pyroelectric Infrared Sensor Network

    PubMed Central

    Xiong, Ji; Li, Fangmin; Zhao, Ning; Jiang, Na

    2014-01-01

    With characteristics of low-cost and easy deployment, the distributed wireless pyroelectric infrared sensor network has attracted extensive interest, which aims to make it an alternate infrared video sensor in thermal biometric applications for tracking and identifying human targets. In these applications, effectively processing signals collected from sensors and extracting the features of different human targets has become crucial. This paper proposes the application of empirical mode decomposition and the Hilbert-Huang transform to extract features of moving human targets both in the time domain and the frequency domain. Moreover, the support vector machine is selected as the classifier. The experimental results demonstrate that by using this method the identification rates of multiple moving human targets are around 90%. PMID:24759117

  18. Detection of Unusual Events and Trends in Complex Non-Stationary Data Streams

    SciTech Connect

    Perez, Rafael B; Protopopescu, Vladimir A; Worley, Brian Addison; Perez, Cristina

    2006-01-01

    The search for unusual events and trends hidden in multi-component, nonlinear, non-stationary, noisy signals is extremely important for a host of different applications, ranging from nuclear power plant and electric grid operation to internet traffic and implementation of non-proliferation protocols. In the context of this work, we define an unusual event as a local signal disturbance and a trend as a continuous carrier of information added to and different from the underlying baseline dynamics. The goal of this paper is to investigate the feasibility of detecting hidden intermittent events inside non-stationary signal data sets corrupted by high levels of noise, by using the Hilbert-Huang empirical mode decomposition method.

  19. Vertebral body recollapse without trauma after kyphoplasty with calcium phosphate cement.

    PubMed

    Piazzolla, Andrea; De Giorgi, Giuseppe; Solarino, Giuseppe

    2011-08-01

    Traditionally, immobilization and external bracing has been recommended for patients with type A traumatic and non-osteoporotic fractures that do not present neurological deficits or significant instability. Nevertheless, several authors have recently suggested the possibility to treat thoraco-lumbar and lumbar vertebral compression post-traumatic fractures using standalone balloon kyphoplasty with osteoconductive filler materials, such as calcium phosphate (CPC). Maestretti and Huang have demonstrated the advantages of this technique showing an almost immediate return to daily activities without the inconvenience of wearing a brace, pain reduction, minimal operative risks and maintenance of stability, therefore proposing this as a first-choice technique in young patient needing rapid spine stability. The authors present a case of vertebral body recollapse after kyphoplasty with calcium phosphate cement (CPC) in a 47-year-old man with an A1.2 post-traumatic L1 compression fracture. PMID:21468725

  20. A Giant Step: From Milli- to Micro- Arcsecond Astrometry (IAU S248)

    NASA Astrophysics Data System (ADS)

    Jin, Wenjing; Platais, Imants; Perryman, Michael A. C.

    2008-08-01

    Preface; Organising committee; Conference participants; Address by the local organising committee C. Huang; Session 1. Hipparcos Catalogue Erik Høg; Session 2. Highlights of optical astrometry Erik H. Høg and François Mignard; Session 3. Astrometry with radio interferometers Edward B. Fomalont; Session 4. Space astrometry: status and the future Alexandre H. Andrei; Session 5. Celestial reference frames at multi-wavelengths Dafydd W. Evans; Session 6. Towards reference frame at the micro-arcsecond level Dafydd W. Evans and Toshio Fukushima; Session 7. Stellar parameters and Galactic structure & evolution Imants Platais and Catherine Turon; Session 8. Astrometric education and outreach Catherine Turon; Session 9. Astrometry in the age of large surveys and virtual observatories Norbert Zacharias; Closing remarks; Author index; Object index; Subject index.

  1. The antihyperglycemic effects of Rhizoma Coptidis and mechanism of actions: a review of systematic reviews and pharmacological research.

    PubMed

    Wang, Hui; Mu, Wei; Shang, Hongcai; Lin, Jia; Lei, Xiang

    2014-01-01

    Rhizoma Coptidis (Huang Lian in Chinese pinyin) is among the most widely used traditional Chinese herbal medicines and has a profound history of more than 2000 years of being used as a therapeutic herb. The antidiabetic effects of Rhizoma Coptidis have been extensively investigated in animal experiments and clinical trials and its efficacy as a promising antihyperglycemic agent has been widely discussed. In the meantime, findings from modern pharmacological studies have contributed the majority of its bioactivities to berberine, the isoquinoline alkaloids component of the herb, and a number of experiments testing the antidiabetic effects of berberine have been initiated. Therefore, we conducted a review of the current evidence profile of the antihyperglycemic effects of Rhizoma Coptidis as well as its main component berberine and the possible mechanism of actions, in order to summarize research evidence in this area and identify future research directions. PMID:24818152

  2. The Antihyperglycemic Effects of Rhizoma Coptidis and Mechanism of Actions: A Review of Systematic Reviews and Pharmacological Research

    PubMed Central

    Wang, Hui; Mu, Wei; Shang, Hongcai; Lin, Jia; Lei, Xiang

    2014-01-01

    Rhizoma Coptidis (Huang Lian in Chinese pinyin) is among the most widely used traditional Chinese herbal medicines and has a profound history of more than 2000 years of being used as a therapeutic herb. The antidiabetic effects of Rhizoma Coptidis have been extensively investigated in animal experiments and clinical trials and its efficacy as a promising antihyperglycemic agent has been widely discussed. In the meantime, findings from modern pharmacological studies have contributed the majority of its bioactivities to berberine, the isoquinoline alkaloids component of the herb, and a number of experiments testing the antidiabetic effects of berberine have been initiated. Therefore, we conducted a review of the current evidence profile of the antihyperglycemic effects of Rhizoma Coptidis as well as its main component berberine and the possible mechanism of actions, in order to summarize research evidence in this area and identify future research directions. PMID:24818152

  3. Investigation of luminescence and optical absorption of K 2LiAlF 6:Cr 3+ single crystals

    NASA Astrophysics Data System (ADS)

    da Silva, M. A. F. M.; Barthem, R. B.; Sosman, L. P.

    2006-12-01

    Photoluminescence, absorption and excitation spectra of K 2LiAlF 6 single crystals doped with 1% of Cr 3+ are presented. The near-infrared photoluminescence observed at room temperature, 77 and 4 K are attributed to the zero-phonon spin-allowed 4T2( 4F) →4A2( 4F) transition of Cr 3+ octahedrally coordinated by F - ions. Lifetimes are obtained. The 4 K emission broad band was described in terms of normal modes of the octahedral complex [CrF 6] 3-. The Racah, crystal-field and Huang-Rhys parameters are calculated and the quantum efficiency and thermal quenching estimated and compared with Cr 3+ properties in different environments.

  4. Taxonomic revision of the East Asian genus Scleropteroides Colonnelli, 1979 (Coleoptera, Curculionidae, Ceutorhynchinae)

    PubMed Central

    Huang, Junhao; Yoshitake, Hiraku; Zhang, Runzhi; Ito, Motomi

    2014-01-01

    Abstract The genus Scleropteroides Colonnelli, 1979 (Ceutorhynchinae: Scleropterini) was revised on the basis of detailed morphological observations. The genus was redefined to include three species from East Asia: S. hypocrita (Hustache, 1916) is redescribed and recorded from northeastern China and northern Korea for the first time; S. horridulus (Voss, 1958) is redescribed with new records from southern Korea; S. insularis Voss, 1971 was moved from synonymy with S. hypocrita to that with S. horridulus (syn. n.), and S. longiprocessus Huang & Yoshitake, sp. n. is described as new, sympatric with S. hypocrita in Japan. All the species are associated with woody Rubus species (Rosaceae). A key to species, habitus photographs, illustrations of important characters, and distribution maps are provided for each species. PMID:25197212

  5. First principles study of the structural, electronic, mechanical and superconducting properties of WX (X=C, N)

    NASA Astrophysics Data System (ADS)

    Kavitha, M.; Sudha Priyanga, G.; Rajeswarapalanichamy, R.; Iyakutti, K.

    2015-02-01

    The structural, electronic, mechanical and superconducting properties of tungsten carbide (WC) and tungsten nitride (WN) are investigated using first principles calculations based on density functional theory (DFT). The computed ground state properties, such as equilibrium lattice constant and cell volume, are in good agreement with the available experimental data. A pressure induced structural phase transition is observed in both tungsten carbide and nitride, from a tungsten carbide phase (WC) to a zinc blende phase (ZB), and from a zinc blende phase (ZB) to a wurtzite phase (WZ). The electronic structure reveals that these materials are metallic at ambient conditions. The calculated elastic constants obey the Born-Huang criteria, suggesting that they are mechanically stable at normal and high pressure. Also, the superconducting transition temperature is estimated for the WC and WN in stable structures at atmospheric pressure.

  6. The non-Gaussian joint probability density function of slope and elevation for a nonlinear gravity wave field. [in ocean surface

    NASA Technical Reports Server (NTRS)

    Huang, N. E.; Long, S. R.; Bliven, L. F.; Tung, C.-C.

    1984-01-01

    On the basis of the mapping method developed by Huang et al. (1983), an analytic expression for the non-Gaussian joint probability density function of slope and elevation for nonlinear gravity waves is derived. Various conditional and marginal density functions are also obtained through the joint density function. The analytic results are compared with a series of carefully controlled laboratory observations, and good agreement is noted. Furthermore, the laboratory wind wave field observations indicate that the capillary or capillary-gravity waves may not be the dominant components in determining the total roughness of the wave field. Thus, the analytic results, though derived specifically for the gravity waves, may have more general applications.

  7. N 2O clusters in a supersonic jet studied by matrix-isolation infrared spectroscopy and density functional theory calculation

    NASA Astrophysics Data System (ADS)

    Kudoh, S.; Onoda, K.; Takayanagi, M.; Nakata, M.

    2000-06-01

    N 2O clusters in a supersonic jet were isolated in a low-temperature argon matrix. The infrared bands of the clusters were assigned with the aid of the results of density functional theory (DFT) calculation where the 6-31+G ∗ basis set is used to optimize geometrical structures. It is concluded that the N⋯O interacting antiparallel conformer is the most stable dimer. This result supports the high-resolution infrared spectroscopic study of Huang and Miller [J. Chem. Phys. 89 (1988) 5408], but disagrees with the recent matrix-isolation study of Nxumalo and Ford [J. Mol. Struct. 327 (1994) 145]. The observed dependence of cluster formation on stagnation pressure is used to examine the cooling effect on supersonic expansion.

  8. Review on the Applications and Molecular Mechanisms of Xihuang Pill in Tumor Treatment

    PubMed Central

    Guo, Qiujun; Lin, Jinyin; Liu, Rui; Gao, Yebo; He, Shulin; Xu, Xinyao; Hua, Baojin; Li, Conghuang; Hou, Wei; Zheng, Honggang; Bao, Yanju

    2015-01-01

    Xihuang pill (XH) is a complementary and alternative medicine that has been used in traditional Chinese medicine (TCM) for the treatment of tumors since the 18th century. XH has clinical effects on non-Hodgkin lymphoma, breast cancer, gastric cancer, liver cancer, and bone metastasis. XH can also inhibit the growth of tumor cells and cancer stem cells, prevent tumor invasion and angiogenesis, and regulate the tumor microenvironment. XH is composed of Ru Xiang (olibanum), Mo Yao (Commiphora myrrha), She Xiang (Moschus), and Niu Huang (Calculus bovis). Some of the compounds found in these ingredients exert multiple antitumor effects and may synergize with the other ingredients. We aimed to summarize the clinical applications and molecular mechanisms of XH and its chemical composition. This review will provide potential new strategies and alternative perspectives for tumor treatments and basic research into complementary and alternative medicine. PMID:26170886

  9. Landau superfluids as nonequilibrium stationary states

    SciTech Connect

    Wreszinski, Walter F.

    2015-01-15

    We define a superfluid state to be a nonequilibrium stationary state (NESS), which, at zero temperature, satisfies certain metastability conditions, which physically express that there should be a sufficiently small energy-momentum transfer between the particles of the fluid and the surroundings (e.g., pipe). It is shown that two models, the Girardeau model and the Huang-Yang-Luttinger (HYL) model, describe superfluids in this sense and, moreover, that, in the case of the HYL model, the metastability condition is directly related to Nozières’ conjecture that, due to the repulsive interaction, the condensate does not suffer fragmentation into two (or more) parts, thereby assuring its quantum coherence. The models are rigorous examples of NESS in which the system is not finite, but rather a many-body system.

  10. Multimodal sensory integration in single cerebellar granule cells in vivo

    PubMed Central

    Ishikawa, Taro; Shimuta, Misa; Häusser, Michael

    2015-01-01

    The mammalian cerebellum is a highly multimodal structure, receiving inputs from multiple sensory modalities and integrating them during complex sensorimotor coordination tasks. Previously, using cell-type-specific anatomical projection mapping, it was shown that multimodal pathways converge onto individual cerebellar granule cells (Huang et al., 2013). Here we directly measure synaptic currents using in vivo patch-clamp recordings and confirm that a subset of single granule cells receive convergent functional multimodal (somatosensory, auditory, and visual) inputs via separate mossy fibers. Furthermore, we show that the integration of multimodal signals by granule cells can enhance action potential output. These recordings directly demonstrate functional convergence of multimodal signals onto single granule cells. DOI: http://dx.doi.org/10.7554/eLife.12916.001 PMID:26714108

  11. Multicomponent AM-FM demodulation based on energy separation and adaptive filtering

    NASA Astrophysics Data System (ADS)

    Qin, Yi

    2013-07-01

    Multicomponent AM-FM demodulation is an important tool in many engineering applications. To improve the demodulation accuracy of the commonly used methods, such as iterative Hilbert transform (IHT) and Hilbert-Huang transform (HHT), a new multicomponent AM-FM demodulation method is proposed in this paper. The proposed method achieves multicomponent demodulation by using an iteratively energy separation algorithm and adaptive low-pass filtering. Using the frequency spectra of instantaneous amplitude and frequency obtained by the energy separation algorithm at each level, the used filters are adaptively designed. In addition, this proposed method uses symmetric extension to solve the boundary effect in the estimation of instantaneous amplitudes and frequencies. The demodulation process is automatic for an arbitrary signal. Simulation and application results show that the proposed method has high demodulation accuracy than IHT, HHT and other typical methods, and it can be effectively applied to extracting weak fault feature from mechanical vibration signals.

  12. Nosema ceranae infection intensity highly correlates with temperature.

    PubMed

    Chen, Yue-Wen; Chung, Wei-Ping; Wang, Chung-Hsiung; Solter, Leellen F; Huang, Wei-Fone

    2012-11-01

    Nosema ceranae, a microsporidian entomopathogen, was first reported from honey bees, Apis mellifera, in 2005 in Taiwan (Huang et al., 2007) and has become a major concern in apiculture worldwide. In Taiwan, we found one infection peak for N. ceranae during the winter months, compared to two peaks in spring and fall reported in 1980 for Nosema apis. N. ceranae infection intensity in apiaries reached a high level earlier than N. apis, a possible factor in replacement. We found a significant negative correlation of N. ceranae pathogen load with temperature; the highest spore counts were recorded at an average temperature of approximately 15 °C and infection intensity equaled the annual average at 23.8 °C. This model corresponds with published results but is most reliable for subtropical to tropical climates. PMID:22982233

  13. [The study on the establishment of acupuncture].

    PubMed

    Jung, Woojin

    2011-12-31

    In ancient china, four famous literatures, Huang Di Nei Jing, Nan Jing, Ben Cao, Shang Han Lun appeared, which made the foundation of oriental medicine. Huang Di Nei Jing, the book of acupuncture, is the most essential literature among these four litertures. So the question asking the identity of oriental medicine can be turned into the question about the identity of acupuncture. The investigation into origin will not be the only way to study of identity but one of the most attractive means. So we can answer with the study of origin to the question about identity. Acupuncture is comprised of theories like jing mai, qi xue and technical factors like moxibustion, bian which is like present operating knife. To trace the origin of acupuncture, we must investigate not only technical factors but also theories. But it will be impossible to trace every theories underlying the acupuncture in this small thesis. This is the reason that I restricted my attention to the principle of preventive medicine, regimen. Before the excavation of Mawangdui, the belief that acupuncture started long ago before Han period had been generally accepted. But there was not any proof proving the presence of acupuncture in the excavated literatures representing the Han period medicine. This fact announced that we must draw the time of establishment of acupuncture back after the Mawangdui literature buried in B.C. 168. But we can find the proof of the presence of acupuncture just before B.C. 168 in Shiji written by Si Mi Qian. Through these facts and inferences that we got until now, we can reach a conclusion that acupuncture would have appeared around 190-176 when Chun Yu Yi was practicing as a doctor. As you know, in the Mawangdui literature, what was associated with jing mai was moxibustion. But at the same time, moxibustion was being used just as the experience medicine technique without theory. So the moxibustion would has been about to be associated with jing mai theory in Mawangdui period. The word zhen jiu, the acupuncture and moxibustion, means there was a way to reconcile two techniques. It was by assuming bu and handing xie over to acupuncture that moxa can coexist with acupuncture. bian is used for infection treatment more than bloodletting tool in ancient china. but there is a bridge between acupuncture with bian. Acupuncture inherited its appearance from bian. It is generally believed that blood-letting is commonly developed in the classic east and west medicine. But the blood-letting could be harmonious with the old chinese belief that vitality must be retained in the body? No. The blood-letting is not generally practiced in ancient china. We can scarcely find the evidence of blood-letting in the ancient literature now in hand except Huang Di Nei Jing. Blood-Letting widened its territory in ancient chinese medicine with the help of the medical version of wuweierwubuwei principle which means 'not do anything, then everything does'. But soon lost its territory. Even in the Huang Di Nei Jing, We can find its disappearance. What is the reason? For its disharmony with chinese life idea, 'not lose essence'. Acupuncture replaced the blood-letting. It was the response of the ancient chinese healers to the regimen spirit and harmonious with chinese life view. Regimen spirit, the medical version of 'wuweierwubuwei' does not pursue cure after being ill but defense before disease. Acupuncture, meeting the demands of time, appeared in pre-han period as the association with jingmai theory which may be developed in regimen field, inheritence of moxa's esperience, and the shape of bian. PMID:22343703

  14. Complex dynamics of a delayed discrete neural network of two nonidentical neurons

    SciTech Connect

    Chen, Yuanlong; Huang, Tingwen; Huang, Yu

    2014-03-15

    In this paper, we discover that a delayed discrete Hopfield neural network of two nonidentical neurons with self-connections and no self-connections can demonstrate chaotic behaviors. To this end, we first transform the model, by a novel way, into an equivalent system which has some interesting properties. Then, we identify the chaotic invariant set for this system and show that the dynamics of this system within this set is topologically conjugate to the dynamics of the full shift map with two symbols. This confirms chaos in the sense of Devaney. Our main results generalize the relevant results of Huang and Zou [J. Nonlinear Sci. 15, 291–303 (2005)], Kaslik and Balint [J. Nonlinear Sci. 18, 415–432 (2008)] and Chen et al. [Sci. China Math. 56(9), 1869–1878 (2013)]. We also give some numeric simulations to verify our theoretical results.

  15. A Two-Stage Approach for Semilinear In-Slide Models

    PubMed Central

    You, Jinhong; Zhou, Haibo

    2008-01-01

    The semilinear in-slide models (SLIMs) have been shown to be effective method for normalizing microarray data (Fan, et al. 2004). Using a backfitting method, Fan, Peng and Huang (2005) proposed a profile least squares (PLS) estimation for the parametric and nonparametric components. The general asymptotic properties for their estimator is not developed. In this paper, we consider a new approach, two-stage estimation, which enables us to establish the asymptotic normalities for both of the parametric and nonparametric component estimators. We further propose a plug-in bandwidth selector using the asymptotic normality of the nonparametric component estimator. The proposed method allow for the modeling of the aggregated SLIMs case where we can explicitly show that taking the aggregated information into account can improve both of the parametric and nonparametric component estimator by the proposed two-stage approach. Some simulation studies are conducted to illustrate the finite sample performance of the proposed procedures. PMID:19802362

  16. Winding string condensation and noncommutative deformation of a spacelike singularity

    SciTech Connect

    She Jianhuang

    2006-08-15

    In a previous paper [Jian-Huang She, J. High Energy Phys. 01 (2006) 002.] using a matrix model, we showed that closed string tachyons can resolve spacelike singularity in one particular class of Misner space (with antiperiodic boundary conditions for fermions around the spatial circle). In this note, we show that for Misner space without closed string tachyons, there also exists a mechanism to resolve the singularity in the context of the matrix model, namely, cosmological winding string production. We show that here space and time also become noncommutative due to these winding strings. Employing the optical theorem, we study the bulk boundary coupling by calculating the four-open-string cylinder amplitudes.

  17. ULF Waves above the Nightside Auroral Oval during Substorm Onset

    NASA Astrophysics Data System (ADS)

    Rae, I. J.; Watt, C. E. J.

    2016-02-01

    This chapter reviews historical ground-based observations of ultra-low-frequency (ULF) waves tied to substorms, and highlights new research linking these ULF waves explicitly to substorm onset itself. There are several robust methods that can be used to determine the characteristics of a nonstationary time series such as the ULF magnetic field traces observed in the auroral zone during substorms. These include the pure state filter, the Hilbert-Huang transform, and wavelet analysis. The first indication of a substorm is a sudden brightening of one of the quiet arcs lying in the midnight sector of the oval. The chapter focuses on the properties of ULF waves that are seen in two-dimensional images of auroral intensity near substorm expansion phase onset. It also discusses a wider range of magnetotail instabilities that could be responsible for the azimuthally structured auroral forms at substorm onset.

  18. Shallow water marine gammaridean amphipods of Pulau Tioman, Malaysia, with the description of a new species

    PubMed Central

    Azman, B.A.R.; Othman, B.H.R.

    2013-01-01

    Abstract Eleven taxa including one new species of gammaridean amphipods are reported from the waters of Pulau Tioman. The presence of Tethygeneia sunda sp. n. represents the first record of the genus from the South China Sea. Additional material of Ampelisca brevicornis (Costa, 1853); Cymadusa vadosa Imbach, 1967; Paradexamine setigera Hirayama, 1984; Ericthonius pugnax (Dana, 1853); Leucothoe furina (Savigny, 1816); Microlysias xenokeras (Stebbing, 1918); Monoculodes muwoni Jo, 1990 are identified from the South China Sea, supporting previous records by Lowry (2000), Huang (1994), Imbach (1967), Margulis (1968) and Nagata (1959). Three additional species, Gitanopsis pusilla K.H. Barnard, 1916, Liljeborgia japonica Nagata, 1965b and Latigammaropsis atlantica (Stebbing, 1888), whilst previously reported from the neighbouring waters, comprise new records for the South China Sea. PMID:24146563

  19. Landau superfluids as nonequilibrium stationary states

    NASA Astrophysics Data System (ADS)

    Wreszinski, Walter F.

    2015-01-01

    We define a superfluid state to be a nonequilibrium stationary state (NESS), which, at zero temperature, satisfies certain metastability conditions, which physically express that there should be a sufficiently small energy-momentum transfer between the particles of the fluid and the surroundings (e.g., pipe). It is shown that two models, the Girardeau model and the Huang-Yang-Luttinger (HYL) model, describe superfluids in this sense and, moreover, that, in the case of the HYL model, the metastability condition is directly related to Nozières' conjecture that, due to the repulsive interaction, the condensate does not suffer fragmentation into two (or more) parts, thereby assuring its quantum coherence. The models are rigorous examples of NESS in which the system is not finite, but rather a many-body system.

  20. [Fuzzy mathematic quantitative law of composing principle in the study of traditional Chinese medicine].

    PubMed

    Liu, Ming; Gao, Yue; Xiao, Rui; Zhang, Bo-li

    2009-01-01

    This study is to analyze microcosmic significance of Chinese medicine composing principle "principal, assistant, complement and mediating guide" and it's fuzzy mathematic quantitative law. According to molecular biology and maximal membership principle, fuzzy subset and membership functions were proposed. Using in vivo experiment on the effects of SiWu Decoction and its ingredients on mice with radiation-induced blood deficiency, it is concluded that DiHuang and DangGui belonged to the principal and assistant subset, BaiShao belonged to the contrary complement subset, ChuanXiong belonged to the mediating guide subset by maximal membership principle. It is discussed that traditional Chinese medicine will be consummate medical science when its theory can be described by mathematic language. PMID:19350819

  1. Herbs in exercise and sports.

    PubMed

    Chen, Chee Keong; Muhamad, Ayu Suzailiana; Ooi, Foong Kiew

    2012-01-01

    The use of herbs as ergogenic aids in exercise and sport is not novel. Ginseng, caffeine, ma huang (also called 'Chinese ephedra'), ephedrine and a combination of both caffeine and ephedrine are the most popular herbs used in exercise and sports. It is believed that these herbs have an ergogenic effect and thus help to improve physical performance. Numerous studies have been conducted to investigate the effects of these herbs on exercise performance. Recently, researchers have also investigated the effects of Eurycoma longifolia Jack on endurance cycling and running performance. These investigators have reported no significant improvement in either cycling or running endurance after supplementation with this herb. As the number of studies in this area is still small, more studies should be conducted to evaluate and substantiate the effects of this herb on sports and exercise performance. For instance, future research on any herbs should take the following factors into consideration: dosage, supplementation period and a larger sample size. PMID:22738233

  2. Herbs in exercise and sports

    PubMed Central

    2012-01-01

    The use of herbs as ergogenic aids in exercise and sport is not novel. Ginseng, caffeine, ma huang (also called 'Chinese ephedra'), ephedrine and a combination of both caffeine and ephedrine are the most popular herbs used in exercise and sports. It is believed that these herbs have an ergogenic effect and thus help to improve physical performance. Numerous studies have been conducted to investigate the effects of these herbs on exercise performance. Recently, researchers have also investigated the effects of Eurycoma longifolia Jack on endurance cycling and running performance. These investigators have reported no significant improvement in either cycling or running endurance after supplementation with this herb. As the number of studies in this area is still small, more studies should be conducted to evaluate and substantiate the effects of this herb on sports and exercise performance. For instance, future research on any herbs should take the following factors into consideration: dosage, supplementation period and a larger sample size. PMID:22738233

  3. Quasiparticle Properties of a Mobile Impurity in a Bose-Einstein Condensate

    NASA Astrophysics Data System (ADS)

    Christensen, Rasmus Søgaard; Levinsen, Jesper; Bruun, Georg M.

    2015-10-01

    We develop a systematic perturbation theory for the quasiparticle properties of a single impurity immersed in a Bose-Einstein condensate. Analytical results are derived for the impurity energy, effective mass, and residue to third order in the impurity-boson scattering length. The energy is shown to depend logarithmically on the scattering length to third order, whereas the residue and the effective mass are given by analytical power series. When the boson-boson scattering length equals the boson-impurity scattering length, the energy has the same structure as that of a weakly interacting Bose gas, including terms of the Lee-Huang-Yang and fourth order logarithmic form. Our results, which cannot be obtained within the canonical Fröhlich model of an impurity interacting with phonons, provide valuable benchmarks for many-body theories and for experiments.

  4. Multi-layer multi-configuration time-dependent Hartree (ML-MCTDH) approach to the correlated exciton-vibrational dynamics in the FMO complex.

    PubMed

    Schulze, Jan; Shibl, Mohamed F; Al-Marri, Mohammed J; Kühn, Oliver

    2016-05-14

    The coupled quantum dynamics of excitonic and vibrational degrees of freedom is investigated for high-dimensional models of the Fenna-Matthews-Olson complex. This includes a seven- and an eight-site model with 518 and 592 harmonic vibrational modes, respectively. The coupling between local electronic transitions and vibrations is described within the Huang-Rhys model using parameters that are obtained by discretization of an experimental spectral density. Different pathways of excitation energy flow are analyzed in terms of the reduced one-exciton density matrix, focussing on the role of vibrational and vibronic excitations. Distinct features due to both competing time scales of vibrational and exciton motion and vibronically assisted transfer are observed. The question of the effect of initial state preparation is addressed by comparing the case of an instantaneous Franck-Condon excitation at a single site with that of a laser field excitation. PMID:27179506

  5. Multi-layer multi-configuration time-dependent Hartree (ML-MCTDH) approach to the correlated exciton-vibrational dynamics in the FMO complex

    NASA Astrophysics Data System (ADS)

    Schulze, Jan; Shibl, Mohamed F.; Al-Marri, Mohammed J.; Kühn, Oliver

    2016-05-01

    The coupled quantum dynamics of excitonic and vibrational degrees of freedom is investigated for high-dimensional models of the Fenna-Matthews-Olson complex. This includes a seven- and an eight-site model with 518 and 592 harmonic vibrational modes, respectively. The coupling between local electronic transitions and vibrations is described within the Huang-Rhys model using parameters that are obtained by discretization of an experimental spectral density. Different pathways of excitation energy flow are analyzed in terms of the reduced one-exciton density matrix, focussing on the role of vibrational and vibronic excitations. Distinct features due to both competing time scales of vibrational and exciton motion and vibronically assisted transfer are observed. The question of the effect of initial state preparation is addressed by comparing the case of an instantaneous Franck-Condon excitation at a single site with that of a laser field excitation.

  6. Two new species of Oobius Trjapitzin (Hymenoptera, Encyrtidae) egg parasitoids of Agrilus spp. (Coleoptera, Buprestidae) from the USA, including a key and taxonomic notes on other congeneric Nearctic taxa.

    PubMed

    Triapitsyn, Serguei V; Petrice, Toby R; Gates, Michael W; Bauer, Leah S

    2015-01-01

    Oobius Trjapitzin (Hymenoptera, Encyrtidae) species are egg parasitoids that are important for the biological control of some Buprestidae and Cerambycidae (Coleoptera). Two species, Oobiusagrili Zhang & Huang and Oobiuslongoi (Siscaro), were introduced into North America for classical biocontrol and have successfully established. Two new native North American species that parasitize eggs of Agrilus spp. (Buprestidae) are described and illustrated from the USA: Oobiusminusculus Triapitsyn & Petrice, sp. n. (Michigan), an egg parasitoid of both Agrilussubcinctus Gory on ash (Fraxinus spp.) and Agrilusegenus Gory on black locust (Robiniapseudoacacia L.) trees, and Oobiuswhiteorum Triapitsyn, sp. n. (Pennsylvania), an egg parasitoid of Agrilusanxius Gory on European white birch (Betulapendula Roth). A taxonomic key and notes on the Nearctic native and introduced Oobius species are also included. PMID:25931963

  7. Mean-field theory for ferroelectricity in Ca3CoMnO6

    SciTech Connect

    Guo, Y. J.; Dong, Shuai; Wang, Kefeng; Liu, J.-M.

    2009-01-01

    An elastic Ising model for CoMnO6 chain is proposed to explain the ferroelectricity induced by collinear magnetic order in Ca3CoMnO6, and then a mean-field theory with interchain spin interactions based on this model is developed. With inclusion of the dynamics of polarization domains at finite temperature, we address the rationality of our theory by the good agreement of the calculated electric polarization and dielectric susceptibility with the reported data on Ca3Co2 xMnxO6 x 0.96 Y. J. Choi, H. T. Yi, S. Lee, Q. Huang, V. Kiryukhin, and S.-W. Cheong, Phys. Rev. Lett. 100, 047601 2008 , a typical diatomic Ising spin chain system, while the predicted magnetic susceptibility shows some difference from experiment, the reason of which is discussed.

  8. Earth science: a wet mantle conductor?

    PubMed

    Hirschmann, Marc

    2006-01-26

    The suggestion that the transition zone of Earth's mantle (410-670 km in depth) is enriched in water is of great possible significance to the geodynamics and geochemistry of Earth's interior, as well as for the role of the mantle in the global water cycle. Huang et al. compare the effect of water on electrical conductivities of transition-zone phases to electromagnetic and magnetotelluric soundings of the mantle beneath the North Pacific and conclude that the transition zone contains between 1,000 and 2,000 p.p.m. of water, which is considerably more than the 50-200 p.p.m. present in the upper mantle. This conclusion is predicated on the assumption that the transition zone is relatively oxidized, but in fact fairly reduced conditions are more likely. Here I show that if the transition zone is reduced, high conductivities can be explained without the requirement for large enrichments of water. PMID:16437063

  9. Influence of intra-pigment vibrations on dynamics of photosynthetic exciton

    SciTech Connect

    Sato, Yoshihiro E-mail: ysato.colby@gmail.com; Doolittle, Brian

    2014-11-14

    We have numerically investigated the effect of an underdamped intra-pigment vibrational mode on an exciton's quantum coherence and energy transfer efficiency. Our model describes a bacteriochlorophyll a pigment-protein dimer under the conditions at which photosynthetic energy transfer occurs. The dimer is modeled using a theoretical treatment of a vibronic exciton, and its dynamics are numerically analyzed using a non-Markovian and non-perturbative method. We examined the system's response to various values of the Huang-Rhys factor, site energy difference, reorganization energy, and reorganization energy difference. We found that the inclusion of the intra-pigment vibronic mode allows for long-lived oscillatory quantum coherences to occur. This excitonic coherence is robust against static site-energy disorder. The vibrational mode also promotes exciton transfer along the site-energy landscape thus improving the overall energy transfer efficiency.

  10. Status and dynamics of the Kobresia pygmaea ecosystem on the Tibetan plateau.

    PubMed

    Miehe, Georg; Miehe, Sabine; Kaiser, Knut; Liu, Jianquan; Zhao, Xinquan

    2008-06-01

    This paper provides information about the distribution, structure, and ecology of the world's largest alpine ecosystem, the Kobresia pygmaea pastures in the southeastern Tibetan plateau. The environmental importance of these Cyperaceae mats derives from the extremely firm turf, which protects large surfaces against erosion, including the headwaters of the Huang He, Yangtze, Mekong, Salween, and Brahmaputra. The emphasis of the present article is on the climate-driven evolution and recent dynamics of these mats under the grazing impact of small mammals and livestock. Considering pedological analyses, radiocarbon datings, and results from exclosure experiments, we hypothesize that the majority of K. pygmaea mats are human-induced and replace forests, scrub, and taller grasslands. At present, the carrying capacity is increasingly exceeded, and reinforced settlement of nomads threatens this ecosystem especially in its drier part, where small mammals become strong competitors with livestock and the removal of the turf is irreversible. Examples of rehabilitation measures are given. PMID:18686506

  11. Effects of various drug therapies on Kleine-Levin syndrome: a case report.

    PubMed

    Yao, Chi-Chun; Lin, Ying; Liu, Hui-Ching; Lee, Chau-Shoun

    2013-01-01

    Kleine-Levin syndrome (KLS) is a rare sleep disorder, predominantly affecting adolescent males, which presents as recurrent episodes of hypersomnia, behavioral and cognitive disturbances, hyperphagia and sometimes hypersexuality (Lisk, "Kleine-Levin syndrome." Pract Neurol 2009;9:42-45). Modafinil has been reported to show an effect in shortening the duration of symptomatic periods, but does not affect the recurrence rate (Huang et al., "Kleine-Levin syndrome: current status." Med Clin N Am 2010;94:557-562). However, no single drug therapy has been consistently successful, despite various psychotropic agents, including lithium, anticonvulsants and antidepressants, having been systematically tried (Arnulf et al., "Kleine-Levin syndrome: a systematic study of 108 patients." Ann Neurol 2008;63:482-492). This study reports a male adolescent with KLS who received several courses of drug therapy, providing a chance to compare differential drug effects over time. PMID:22520717

  12. Partial equilibrium approximations in apoptosis. II. The death-inducing signaling complex subsystem.

    PubMed

    Huang, Ya-Jing; Hong, Liu; Yong, Wen-An

    2015-12-01

    This paper is a continuation of our previous work (Huang and Yong, 2013) for simplifying the Fas signaling-induced apoptotic pathway identified by Hua et al. (2005) for human tumor T cells. The previous paper studied the downstream intracelluar-signaling subsystem, while the present one is concerned with the upstream death-inducing signaling complex (DISC) subsystem. Under the assumption that the bind of Fas-associated death domains and FLICE-inhibitory proteins to the DISC is much faster than that of the initiator procaspases, we greatly simplify the upstream subsystem from 35 reactions with 26 species to 6 reactions with 9 species by adopting the classical and recently justified partial equilibrium approximation method. Numerical simulations show that the simplified model is in an excellent agreement with the original model. Most importantly, the simplified model clearly reveals the key reactants and dominated pathways in the Fas signaling process, and thus provides new insights into the apoptosis. PMID:26524142

  13. Local finite-amplitude wave activity as an objective diagnostic of midlatitude extreme weather

    NASA Astrophysics Data System (ADS)

    Chen, Gang; Lu, Jian; Burrows, D. Alex; Leung, L. Ruby

    2015-12-01

    Midlatitude extreme weather events are responsible for a large part of climate-related damage, yet our understanding of these extreme events is limited, partly due to the lack of a theoretical basis for midlatitude extreme weather. In this letter, the local finite-amplitude wave activity (LWA) of Huang and Nakamura (2015) is introduced as a diagnostic of the 500 hPa geopotential height for characterizing midlatitude weather events. It is found that the LWA climatology and its variability associated with the Arctic Oscillation agree broadly with the previously reported blocking frequency in the literature. There is a strong seasonal and spatial dependence in the trends of LWA in recent decades. While there is no observational evidence for a hemispheric-scale increase in wave amplitude, robust trends in wave activity can be identified at the regional scales, with important implications for regional climate change.

  14. Surface and interface phonon-polaritons in freestanding quantum well wire systems of polar ternary mixed crystals

    NASA Astrophysics Data System (ADS)

    Yan, C. L.; Bao, J.; Yan, Z. W.

    2016-03-01

    The surface and interface phonon-polaritons in freestanding rectangular quantum well wire systems consisting of polar ternary mixed crystals are investigated in the modified random-element-isodisplacement model and the Born-Huang approximation, based on the Maxwell's equations with the boundary conditions. The numerical results of the surface and interface phonon-polariton frequencies as functions of the wave-vector, geometric structure, and the composition of the ternary mixed crystals in GaAs/AlxGa1-xAs and ZnxCd1-xSe/ZnSe quantum well wire systems are obtained and discussed. It is shown that there are 10 and 8 branches of surface and interface phonon-polaritons in the two quantum well wire systems respectively. The effects of the "two-mode" and "one-mode" behaviors of the ternary mixed crystals on the surface and interface phonon-polariton modes are shown in the dispersion curves.

  15. Preface to the Eighth International Conference on Aeolian Research - ICAR 8

    NASA Astrophysics Data System (ADS)

    Dong, Zhibao; Huang, Ning

    2015-12-01

    The papers in this special issue of Aeolian Research arise from the Eighth International Conference on Aeolian Research (ICAR8), held on July 21-25, 2014 at Lanzhou University, China. The conference was sponsored by the International Society for Aeolian Research, convened by Zhibao Dong and Ning Huang, and supported by several institutions from China. The conference was well attended by 284 participants from 20 nations. 138 oral presentations, 142 posters and 296 abstracts were organized into six sessions. The 13 papers that appear in this special issue are drawn from the post-conference submissions, which were successfully reviewed by peers, revised and accepted. Those papers that have not completed review will become regular submissions to Aeolian Research and published (if accepted) when they pass review process.

  16. Non-ideal boson system in the Gaussian approximation

    SciTech Connect

    Tommasini, P.R.; de Toledo Piza, A.F.

    1997-01-01

    We investigate ground-state and thermal properties of a system of non-relativistic bosons interacting through repulsive, two-body interactions in a self-consistent Gaussian mean-field approximation which consists in writing the variationally determined density operator as the most general Gaussian functional of the quantized field operators. Finite temperature results are obtained in a grand canonical framework. Contact is made with the results of Lee, Yang, and Huang in terms of particular truncations of the Gaussian approximation. The full Gaussian approximation supports a free phase or a thermodynamically unstable phase when contact forces and a standard renormalization scheme are used. When applied to a Hamiltonian with zero range forces interpreted as an effective theory with a high momentum cutoff, the full Gaussian approximation generates a quasi-particle spectrum having an energy gap, in conflict with perturbation theory results. {copyright} 1997 Academic Press, Inc.

  17. Intrinsic and extrinsic effects on electron-phonon coupling strength in individual ZnTe nanowires: The effects of laser annealing and metallic Te

    NASA Astrophysics Data System (ADS)

    Marmon, Jason; Sheng, Tao; Zhang, Haitao; Zhang, Yong

    2015-03-01

    Electron-phonon coupling is typically studied as an intrinsic property for a given bulk material, and modifying the coupling has been explored in a nanostructure. We point out that the coupling strength can be easily perturbed both significantly and unintentionally. Nanowires, with their large surface-to-volume ratio, are more susceptible to extrinsic perturbations that affect coupling strength, although literature assumes that coupling is intrinsic. This work uses Raman spectroscopy under a near resonant condition to probe the coupling strength of individual ZnTe nanowires. Using the intensity ratio of the first and second order Raman peaks, R = I2LO/I1LO, as a measure of the electron-phonon coupling strength (proportional to the Huang-Rhys factor), we find that the ratio can change greatly when varying either the sample or measurement condition, for instance, the presence of defects in the as-grown sample and their removal though laser illumination.

  18. Revisiting the emission from relativistic blast waves in a density-jump medium

    SciTech Connect

    Geng, J. J.; Huang, Y. F.; Dai, Z. G.; Wu, X. F.; Li, Liang E-mail: dzg@nju.edu.cn

    2014-09-01

    Re-brightening bumps are frequently observed in gamma-ray burst afterglows. Many scenarios have been proposed to interpret the origin of these bumps, of which a blast wave encountering a density-jump in the circumburst environment has been questioned by recent works. We develop a set of differential equations to calculate the relativistic outflow encountering the density-jump by extending the work of Huang et al. This approach is a semi-analytic method and is very convenient. Our results show that late high-amplitude bumps cannot be produced under common conditions, rather only a short plateau may emerge even when the encounter occurs at an early time (<10{sup 4} s). In general, our results disfavor the density-jump origin for those observed bumps, which is consistent with the conclusion drawn from full hydrodynamics studies. The bumps thus should be caused by other scenarios.

  19. An alternative approach to characterize nonlinear site effects

    USGS Publications Warehouse

    Zhang, R.R.; Hartzell, S.; Liang, J.; Hu, Y.

    2005-01-01

    This paper examines the rationale of a method of nonstationary processing and analysis, referred to as the Hilbert-Huang transform (HHT), for its application to a recording-based approach in quantifying influences of soil nonlinearity in site response. In particular, this paper first summarizes symptoms of soil nonlinearity shown in earthquake recordings, reviews the Fourier-based approach to characterizing nonlinearity, and offers justifications for the HHT in addressing nonlinearity issues. This study then uses the HHT method to analyze synthetic data and recordings from the 1964 Niigata and 2001 Nisqually earthquakes. In doing so, the HHT-based site response is defined as the ratio of marginal Hilbert amplitude spectra, alternative to the Fourier-based response that is the ratio of Fourier amplitude spectra. With the Fourier-based approach in studies of site response as a reference, this study shows that the alternative HHT-based approach is effective in characterizing soil nonlinearity and nonlinear site response.

  20. The bromine content of micrometeorites - Arguments for stratospheric contamination

    NASA Technical Reports Server (NTRS)

    Rietmeijer, Frans J. M.

    1993-01-01

    Bromine-salt nanocrystals are associated with a porous chondritic micrometeorite (W7029E5) that was collected in the lower stratosphere. These salt nanocrystals occur together with volcanic Na and K salt nanocrystals embedded in sulfuric acid droplets that were originally adhered to the particle. These materials were concentrated during hexane rinsing as part of routine curation procedures at the NASA Johnson Space Center Cosmic Dust Curatorial Facility. This observation is fortuitous to the extent that the concentration of nanocrystals and sulfuric acid is an experimental artifact of curation. If bromine is a stratospheric contaminant due to surface adsorption, there should be a positive linear relationship between the mass-normalized residence time and bromine content of individual micrometeorites. I show that the predicted correlation exists using a new model to calculate the stratospheric residence time of individual nonspherical micrometeorites in the slow-settling Wilson-Huang regime of the stratosphere.

  1. A qualitative study of seismic-ionospheric precursor phenomena monitored by a very close to the epicenter VLF and LF receiver

    NASA Astrophysics Data System (ADS)

    Skeberis, C.; Zaharis, Z. D.; Xenos, T. D.; Spatalas, S.; Contadakis, M. E.

    2015-12-01

    This work investigates the occurrence of disturbances across a wide range of VLF and LF frequencies received prior to a seismic event (Mw = 4), that took place on May 12th 2012, the epicenter of which was very close (14 km) to the VLF/LF station. The signals analyzed were emitted from five VLF and five LF European transmitters. This seismic event produced precursory ionospheric disturbances, identified as spectral distortion, three days before its occurrence, providing a distinct pattern open to further investigation. Although the basis of the ionosphere interaction with seismic phenomena has been well documented in previous studies, the close proximity of the receiver to the seismic event provides a new perspective to this study. The monitored signals have undergone normalization and then they have been processed by means of the Hilbert-Huang Transform. Diagrams of the signals relevant to the phenomena are presented and the disturbances that are present in the raw data are accentuated through further processing.

  2. Reply to the comment by Boulila and Hinnov towards "Chronology of the Early Toarcian environmental crisis in the Lorraine Sub-Basin (NE Paris Basin)" by W. Ruebsam, P. Münzberger, and L. Schwark [Earth and Planetary Science Letters 404 (2014) 273-282

    NASA Astrophysics Data System (ADS)

    Ruebsam, Wolfgang; Münzberger, Petra; Schwark, Lorenz

    2015-04-01

    Recently Boulila and Hinnov provided an alternative interpretation for the cyclostratigraphy of the Early Toarcian in the Lorraine Basin proposed by Ruebsam et al. (2014). Floating chronologies based on cyclostratigraphy, in particular when discrete time lines (e.g. tephra layers, intrusions, etc.) are missing, are subject to contrasting interpretation and discussion as exemplified for the Early Toarcian by previous contributions (e.g. Kemp et al., 2011; Boulila et al., 2014; Huang and Hesselbo, 2014). In the following we address the discussion raised by Boulila and Hinnov with specific focus on differential sedimentation rates in sub-basins on the NW-Tethyan Shelf during the Early Toarcian and how this may have affected i) the duration of individual ammonite (sub)zones and the Toarcian carbon isotopic excursion, ii) the expression of a 405 ka cycle and iii) the obliquity-forcing on paleoclimate.

  3. Confined optical-phonon-assisted cyclotron resonance in quantum wells via two-photon absorption process

    NASA Astrophysics Data System (ADS)

    Phuc, Huynh Vinh; Hien, Nguyen Dinh; Dinh, Le; Phong, Tran Cong

    2016-06-01

    The effect of confined phonons on the phonon-assisted cyclotron resonance (PACR) via both one and two photon absorption processes in a quantum well is theoretically studied. We consider cases when electrons are scattered by confined optical phonons described by the Fuchs-Kliewer slab, Ridley's guided, and Huang-Zhu models. The analytical expression of the magneto-optical absorption coefficient (MOAC) is obtained by relating it to the transition probability for the absorption of photons. It predicts resonant peaks caused by transitions between Landau levels and electric subband accompanied by confined phonons emission in the absorption spectrum. The MOAC and the full-width at half-maximum (FWHM) for the intra- and inter-subband transitions are given as functions of the magnetic field, temperature, and quantum well width. In narrow quantum wells, the phonon confinement becomes more important and should be taken into account in studying FWHM.

  4. Comment on multifractal diffusion entropy analysis on stock volatility in financial markets [Physica A 391 (2012) 5739-5745

    NASA Astrophysics Data System (ADS)

    Morozov, A. Yu.

    2013-05-01

    In their recent article multifractal diffusion entropy analysis on stock volatility in financial markets Huang, Shang and Zhao (2012) [6] suggested a generalization of the diffusion entropy analysis method with the main goal of being able to reveal scaling exponents for multifractal times series. The main idea seems to be replacing the Shannon entropy by the Rnyi entropy, which is a one-parametric family of entropies. The authors claim that based on their method they are able to separate long range and short correlations of financial market multifractal time series. In this comment I show that the suggested new method does not bring much valuable information in obtaining the correct scaling for a multifractal/mono-fractal process beyond the original diffusion entropy analysis method. I also argue that the mathematical properties of the multifractal diffusion entropy analysis should be carefully explored to avoid possible numerical artefacts when implementing the method in analysis of real sequences of data.

  5. Quantum studies of the vibrations in H3O2- and D3O2-

    NASA Astrophysics Data System (ADS)

    McCoy, Anne B.; Huang, Xinchuan; Carter, Stuart; Bowman, Joel M.

    2005-08-01

    The vibrations of H3O2- and D3O2- are investigated using diffusion Monte Carlo (DMC) and vibrational configuration-interaction approaches, as implemented in the program MULTIMODE. These studies use the potential surface recently developed by Huang et al. [ J. Am. Chem. Soc. 126, 5042 (2004)]. The focus of this work is on the vibrational ground state and fundamentals which occur between 100 and 3700cm-1. In most cases, excellent agreement is obtained between the fundamental frequencies calculated by the two approaches. This serves to demonstrate the power of both methods for treating this very anharmonic system. Based on the results of the MULTIMODE and DMC treatments, the extent and nature of the couplings in H3O2- and D3O2- are investigated.

  6. Simultaneous ionization and excitation of helium by electron impact

    NASA Astrophysics Data System (ADS)

    Dal Cappello, C.; Roy, A. C.; Ren, X. G.; Dey, R.

    2008-02-01

    We present numerical results for He (1s2) (e, 2e) He+ reaction process for transitions to the n = 1, 2 and 3 states of He+ for noncoplanar symmetric geometry at incident energies of 1000 and 1600 eV. The calculations are performed using the plane wave impulse approximation (PWIA) and the 3C method (also called the Brauner, Briggs and Klar (BBK) model) that includes post collision interaction and multiple scattering effects. In both the methods we have used the highly correlated configuration interaction wave function for the ground state of helium. A comparison of the present theoretical cross sections with the recent measured data of Ren et al. [X.G. Ren, C.G. Ning, J.K. Deng, G.L. Su, S.F. Zhang, Y.R. Huang, G.Q. Li, Phys. Rev. A 72 (2005) 042718] shows reasonably good agreement.

  7. Kinetic Isotope Effects for the Reactions of Muonic Helium and Muonium with H2

    SciTech Connect

    Fleming, Donald G.; Arseneau, Donald J.; Sukhorukov, Oleksandr; Brewer, Jess H.; Mielke, Steven L.; Schatz, George C.; Garrett, Bruce C.; Peterson, Kirk A.; Truhlar, Donald G.

    2011-01-28

    The neutral muonic helium atom may be regarded as the heaviest isotope of the hydrogen atom, with a mass of ~4.1 amu (4.1H), because the negative muon screens one proton charge. We report the reaction rate of 4.1H with 1H2 to produce 4.1H1H + 1H at 295 to 500 K. The experimental rate constants are compared with the predictions of accurate quantum mechanical dynamics calculations carried out on an accurate Born-Huang potential energy surface and with previously measured rate constants of 0.11H (where 0.11H is shorthand for muonium). Kinetic isotope effects can be compared for the unprecedentedly large mass ratio of 36. The agreement with accurate quantum dynamics is quantitative at 500 K, and variational transition state theory is used to interpret the extremely low (large inverse) kinetic isotope effects in the 10-4 to 10-2 range.

  8. On the quantitative absorption and Stokes shift in PbSe quantum dots embedded in glasses

    NASA Astrophysics Data System (ADS)

    Ma, De-Wei; Jiang, Hui-Lv; Cheng, Cheng

    2015-01-01

    The synthesis of PbSe quantum dots (QDs) in silicate glasses was achieved by a simple melt-annealing technique. Transmission electron microscopy analysis proves the formation of PbSe QDs in glasses. The absorption spectra show that the light absorption originates from the PbSe QDs in glasses mostly, and the energy-integrated molar extinction coefficient for the first exciton transition was deemed to be only about 1/10 of those from colloidal PbSe QDs. The photoluminescence analysis reveals that the Forster energy transfer is responsible for the shape of the PL peak. For the sample with PbSe QDs in a small radius of 5.2 nm, a pronounced Stokes shift of 70 meV was found, and the Huang-Rhys factor was calculated to be 2.1.

  9. Post-buckling analysis for the precisely controlled buckling of thin film encapsulated by elastomeric subsrates.

    SciTech Connect

    Jiang, H.; Sun, Y.; Rogers, J. A.; Huang, Y.; Arizona State Univ.; Univ. of Illinois; Northwestern Univ.

    2008-04-01

    The precisely controlled buckling of stiff thin films (e.g., Si or GaAs nano ribbons) on the patterned surface of elastomeric substrate (e.g., poly(dimethylsiloxane) (PDMS)) with periodic inactivated and activated regions was designed by Sun et al. [Sun, Y., Choi, W.M., Jiang, H., Huang, Y.Y., Rogers, J.A., 2006. Controlled buckling of semiconductor nanoribbons for stretchable electronics. Nature Nanotechnology 1, 201-207] for important applications of stretchable electronics. We have developed a post-buckling model based on the energy method for the precisely controlled buckling to study the system stretchability. The results agree with Sun et al.'s (2006) experiments without any parameter fitting, and the system can reach 120% stretchability.

  10. Electronic Spectrum of C7H3+ in the Gas Phase at 10 K

    NASA Astrophysics Data System (ADS)

    Rice, C. A.; Hardy, F.-X.; Gause, O.; Maier, J. P.

    2015-10-01

    The analysis of the λ5797.1 diffuse interstellar band (DIB) by Huang & Oka concludes that the carrier is a chain-like molecule with five to seven heavy atoms with a large oscillator strength, f ≈ 1, for the electronic transition. The spectra of carbon chains of this size with transitions in the visible have been obtained in the gas phase, but the f-values are too small. We have now found that certain carbon-chain cations with transitions in the DIB range have large f-values. An example is the origin band at 4387.7 Å of the 1 1A{}1 ≤ftarrow X{ }1A1 electronic transition of the H2C7H+ chain with f ≈ 0.3. This could be measured in the gas phase at 10 K in an ion trap. Astrophysical relevance of such cations is discussed.

  11. Skeleton graph expansion of critical exponents in "cultural revolution" years

    NASA Astrophysics Data System (ADS)

    Hao, Bailin

    2014-04-01

    Kenneth Wilson's Nobel Prize winning breakthrough in the renormalization group theory of phase transition and critical phenomena almost overlapped with the violent "cultural revolution" years (1966-1976) in China. An unexpected chance in 1972 brought the author of these lines close to the Wilson-Fisher ɛ-expansion of critical exponents and eventually led to a joint paper with Lu Yu published entirely in Chinese without any English title and abstract. Even the original acknowledgment was deleted because of mentioning foreign names like Kenneth Wilson and Kerson Huang. In this article I will tell the 40-year old story as a much belated tribute to Kenneth Wilson and to reproduce the essence of our work in English. At the end, I give an elementary derivation of the Callan-Symanzik equation without referring to field theory.

  12. Thermodynamic Database for the NdO(1.5)-YO(1.5)-YbO(1.5)-ScO(1.5)-ZrO2 System

    NASA Technical Reports Server (NTRS)

    Jacobson, Nathan S.; Copland, Evan H.; Kaufman, Larry

    2001-01-01

    A database for YO(1.5)-NdO(1.5)-YbO(1.5)-ScO(1.5)-ZrO2 for ThermoCalc (ThermoCalc AB, Stockholm, Sweden) has been developed. The basis of this work is the YO(1.5)-ZrO2 assessment by Y. Du, Z. Jin, and P. Huang, 'Thermodynamic Assessment of the ZrO2-YO(1.5) System'. Experimentally only the YO(1.5)-ZrO2 system has been well-studied. All other systems are only approximately known. The major simplification in this work is the treatment of each single cation unit as a component. The pure liquid oxides are taken as reference states and two term lattice stability descriptions are used for each of the components. The limited experimental phase diagrams are reproduced.

  13. Relaxation times of the two-phonon processes with spin-flip and spin-conserving in quantum dots

    SciTech Connect

    Wang, Zi-Wu; Liu, Lei; Li, Shu-Shen

    2014-04-07

    We perform a theoretical investigation on the two-phonon processes of the spin-flip and spin-conserving relaxation in quantum dots in the frame of the Huang-Rhys' lattice relaxation model. We find that the relaxation time of the spin-flip is two orders of magnitude longer than that of the spin-conserving, which is in agreement with previous experimental measurements. Moreover, the opposite variational trends of the relaxation time as a function of the energy separation for two-phonon processes are obtained in different temperature regime. The relaxation times display the oscillatory behaviors at the demarcation point with increasing magnetic field, where the energy separation matches the optical phonon energy and results in the optical phonon resonance. These results are useful in understanding the intraband levels' relaxation in quantum dots and could be helpful in designing photoelectric and spin-memory devices.

  14. Skeleton graph expansion of critical exponents in "cultural revolution" years

    NASA Astrophysics Data System (ADS)

    Hao, Bailin

    Kenneth Wilson's Nobel Prize winning breakthrough in the renormalization group theory of phase transition and critical phenomena almost overlapped with the violent "cultural revolution" years (1966-1976) in China. An unexpected chance in 1972 brought the author of these lines close to the Wilson-Fisher є-expansion of critical exponents and eventually led to a joint paper with Lu Yu published entirely in Chinese without any English title and abstract. Even the original acknowledgment was deleted because of mentioning foreign names like Kenneth Wilson and Kerson Huang. In this article I will tell the 40-year old story as a much belated tribute to Kenneth Wilson and to reproduce the essence of our work in English. At the end, I give an elementary derivation of the Callan-Symanzik equation without referring to field theory.

  15. Hazard analysis for 300 Area N Reactor Fuel Fabrication and Storage Facilty

    SciTech Connect

    Johnson, D.J.; Brehm, J.R.

    1994-01-25

    This hazard analysis (HA) has been prepared for the 300 Area N Reactor Fuel Fabrication and Storage Facility (Facility), in compliance with the requirements of Westinghouse Hanford Company (Westinghouse Hanford) controlled manual WHC-CM-4-46, Nonreactor Facility Safety Analysis Manual, and to the direction of WHC-IP-0690, Safety Analysis and Regulation Desk Instructions, (WHC 1992). An HA identifies potentially hazardous conditions in a facility and the associated potential accident scenarios. Unlike the Facility hazard classification documented in WHC-SD-NR-HC-004, Hazard Classification for 300 Area N Reactor Fuel Fabrication and Storage Facility, (Huang 1993), which is based on unmitigated consequences, credit is taken in an HA for administrative controls or engineered safety features planned or in place. The HA is the foundation for the accident analysis. The significant event scenarios identified by this HA will be further evaluated in a subsequent accident analysis.

  16. Simulation and signal processing of through wall UWB radar for human being's periodic motions detection

    NASA Astrophysics Data System (ADS)

    Li, Jing; Liu, Fengshan; Xu, Penglong; Zeng, Zhaofa

    2013-05-01

    The human's Micro-Doppler signatures resulting from breathing, arm, foot and other periodic motion can provide valuable information about the structure of the moving parts and may be used for identification and classification purposes. In this paper, we carry out simulate with FDTD method and through wall experiment with UWB radar for human being's periodic motion detection. In addition, Advancements signal processing methods are presented to classify and to extract the human's periodic motion characteristic information, such as Micro-Doppler shift and motion frequency. Firstly, we apply the Principal Component Analysis (PCA) with singular value decomposition (SVD) to denoise and extract the human motion signal. Then, we present the results base on the Hilbert-Huang transform (HHT) and the S transform to classify and to identify the human's micro-Doppler shift characteristics. The results demonstrate that the combination of UWB radar and various processing methods has potential to detect human's Doppler signatures effectively.

  17. Geometrical Scaling of an Ablative Bluff Body under Different Outer Flow Velocity and Temperature Configurations

    NASA Astrophysics Data System (ADS)

    Allard, Michael; White, Christopher M.; Dubief, Yves

    2015-11-01

    Experimental results investigating the geometrical scaling and local properties of an eroding low temperature ablator (para-dichlorobenzene) are presented. The bluff body is placed in a heated open-circuit wind tunnel and the effects of incoming outer flow velocity (uniform and spatially varying) and temperature on the ablation process are investigated. Image sequencing of the projected area in the streamwise-spanwise and streamwise-wall normal flow direction are used to quantify the time evolution of the geometrical shape and compute local recession rates and curvature. The geometrical self-similarity and local recession rates are evaluated and compared to Moore et al. and Huang et al. who investigated erosion under the action of fluid shear force and dissolution, respectively. This work is supported by the NSF (CBET-0967224).

  18. Topside Ionospheric Profile Constructed with ROCSAT Observation and Jicamarca Ionosonde Data

    NASA Astrophysics Data System (ADS)

    Tulasi Ram, S.; Su, S.; Liu, C.

    2009-05-01

    Topside ionospheric profile is constructed using simple Chapman-alpha function to connect the ROCSAT observed density at the 600-km altitude to the bottomside ionosphere measured by the ionosonde at Jicamarca. We found that the constructed topside density profiles are almost identical to the Jicamarca ISR measurements in several examples and are all superior to other approaches such as the Huang-Reinisch method and the IRI 2007 model. The local time variation of the effective topside scale height in the Chapman- alpha function for the December solstice in 2003 indicates a low ion temperature in the morning hours that is quite different from the ion temperature measured by ROCSAT at the 600-km altitude where the temperature rises rapidly at sunrise. The discrepancy between the two temperatures can be explained by the vertical variation in the topside ionospheric temperature during the morning hour and is confirmed from a result in the SAM2 model.

  19. Linking typhoon tracks with rainfall patterns and flood timing

    NASA Astrophysics Data System (ADS)

    Balcerak, Ernie

    2012-11-01

    Being able to predict the timing and amount of flooding during and following a hurricane or typhoon would improve early warning and mitigation efforts. However, variable typhoon tracks and interaction between typhoons and varied landscapes make flood prediction challenging. Huang et al. investigated the detailed distribution of typhoon-induced rainfall over a mesoscale mountainous watershed located in eastern Taiwan, a region that is regularly affected by severe typhoonslosses associated with typhoons in Taiwan can reach $500 million per year. The researchers analyzed high-resolution radar observations of 38 rainfall events during 2000-2010 in eastern Taiwan to study the relationship between typhoon track, rainfall patterns, and the timing of peak flooding.

  20. Nonlinear, non-stationary image processing technique for eddy current NDE

    NASA Astrophysics Data System (ADS)

    Yang, Guang; Dib, Gerges; Kim, Jaejoon; Zhang, Lu; Xin, Junjun; Udpa, Lalita

    2012-05-01

    Automatic analysis of eddy current (EC) data has facilitated the analysis of large volumes of data generated in the inspection of steam generator tubes in nuclear power plants. The traditional procedure for analysis of EC data includes data calibration, pre-processing, region of interest (ROI) detection, feature extraction and classification. Accurate ROI detection has been enhanced by pre-processing, which involves reducing noise and other undesirable components as well as enhancing defect indications in the raw measurement. This paper presents the Hilbert-Huang Transform (HHT) for feature extraction and support vector machine (SVM) for classification. The performance is shown to significantly better than the existing rule based classification approach used in industry.