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1

Unilateral vagotomy inhibits compensatory kidney growth after unilateral nephrectomy in rats.  

PubMed

The effect of unilateral vagotomy on compensatory renal growth that follows unilateral nephrectomy was studied. Unilateral vagotomy inhibited the usual compensatory growth of the remaining kidney. Unilateral vagotomy did not effect kidney weight in animals with two kidneys. Data indicate that the vagus nerve is involved in the development of compensatory kidney hypertrophy. PMID:3825553

Gerendai, I; Nemeskéri, A; Halász, B

1986-01-01

2

Unilateral Hemiparesis with Thoracic Epidural in an Adolescent  

PubMed Central

Objective. Unilateral sensory and motor blockade is known to occur with epidural anesthesia but is rarely reported in children. The differential diagnosis should include the presence of a midline epidural septum. Case Report. We describe a case of a 16-year-old adolescent who developed repeated complete unilateral extensive epidural sensory and motor blockade with Horner's syndrome after thoracic epidural catheter placement. This unusual presentation of complete hemibody neural blockade has not been reported in the pediatric population. Maneuvers to improve contralateral uniform neural blockade were unsuccessful. An epidurogram was performed to ascertain the correct location of the catheter within the epidural space and presence of sagittal compartmentalization. Conclusion. This case report highlights a less frequently reported reason for unilateral sensory and motor blockade with epidural anesthesia in children. The presence of a midline epidural septum should be considered in the differential diagnosis of unilateral epidural blockade. PMID:22606409

Tassone, Rosalie F.; Seefelder, Christian; Sethna, Navil F.

2012-01-01

3

Long-term risk of chronic kidney disease in unilateral multicystic dysplastic kidney  

Microsoft Academic Search

The clinical spectrum of renal dysplasia includes the non-functioning multicystic dysplastic kidney (MCDK). We report our\\u000a experience of the outcome of unilateral MCDK and its contralateral kidney in 101 children with the diagnosis of MCDK from\\u000a 1985 to 2009. Data collected included urine protein\\/creatinine ratio, estimated GFR (eGFR), blood pressure, surgical intervention,\\u000a renal length and abnormalities of the contralateral kidney,

Omer Mansoor; Jayanthi Chandar; Maria M. Rodriguez; Carolyn L. Abitbol; Wacharee Seeherunvong; Michael Freundlich; Gaston Zilleruelo

2011-01-01

4

Percutaneous nephrolithotomy: Effect of unilateral procedure on contralateral kidney function  

PubMed Central

Background: Although long-term effects of percutaneous nephrolithotomy (PCNL) on renal function and structure have been evaluated, knowledge regarding the immediate effects of surgery on renal function is limited. We conducted this study to evaluate the impact of unilateral PCNL on bilateral renal function during immediate post-operative period. Materials and Methods: From April to September 2012, 40 eligible patients were enrolled in this study and underwent unilateral PCNL. During the post-operative period, creatinine clearances (CrCl) of treated and untreated sides were estimated separately and pattern of changes in bilateral renal function following this procedure was evaluated. Results: Following the operation, CrCl of both kidneys showed a similar pattern of changes, of course more dramatic on treated side. We observed progressive decline in CrCl of both sides followed by bilateral improvement in renal function toward pre-operative values. Conclusions: During the early post-operative period following unilateral PCNL, both kidneys experienced a temporary drop in function warranting more intensive post-operative care. PMID:25538913

Sichani, Mehrdad Mohammadi; Behnamfar, Amir; Khorami, Mohammad Hatef; Nourimahdavi, Kia; Alizadeh, Farshid; Izadpanahi, Mohammad Hossein

2014-01-01

5

Pulmonary endothelial dysfunction induced by unilateral as compared to bilateral thoracic irradiation in rats  

SciTech Connect

Rats were sacrificed 2 months after a single dose of 10-30 Gy of /sup 60/Co gamma rays delivered to either a right unilateral or a bilateral thoracic port. Four indices of lung endothelial function were measured: the activities of angiotensin-converting enzyme (ACE) and plasminogen activator (PLA) and the production of prostacyclin (PGI2) and thromboxane (TXA2). The number of macrophages recovered by bronchoalveolar lavage (BAL) and the degree of right ventricular hypertrophy (an index of pulmonary hypertension) also were determined. Right lung ACE and PLA activity decreased linearly, and PGI2 and TXA2 production increased linearly with increasing radiation dose. The response curves for right unilateral and bilateral thoracic irradiation were not significantly different. In contrast, bilateral irradiation was more toxic than unilateral, since rats exposed to the former exhibited decreased body weight, an increased incidence of pleural effusions, an increase in the number of macrophages recovered by BAL, and right ventricular hypertrophy. These data demonstrate that pulmonary endothelial dysfunction induced by hemithorax irradiation represents a direct response of the endothelium to radiation injury and is not secondary to other phenomena such as shunting of function to the shielded lung.

Ward, W.F.; Molteni, A.; Ts'Ao, C.H.; Solliday, N.H.

1987-07-01

6

Long-term risk of chronic kidney disease in unilateral multicystic dysplastic kidney.  

PubMed

The clinical spectrum of renal dysplasia includes the non-functioning multicystic dysplastic kidney (MCDK). We report our experience of the outcome of unilateral MCDK and its contralateral kidney in 101 children with the diagnosis of MCDK from 1985 to 2009. Data collected included urine protein/creatinine ratio, estimated GFR (eGFR), blood pressure, surgical intervention, renal length and abnormalities of the contralateral kidney, and the involution rate. There was a predominance of left-sided MCDK. Diagnosis was made prenatally in 86.7%. Contralateral abnormalities included vesicoureteral reflux (16.8%), UPJ obstruction (4.1%), and megaureter (2.4%). Complete involution of MCDK occurred within 5 years in 60%. Compensatory hypertrophy of the contralateral kidney to >97% occurred in 74.1%. Nephrectomy was performed in 19.8%. There was an increased risk of chronic kidney disease (CKD) stage ? 2, and hypertension in those with contralateral abnormalities (p<0.0001; p<0.001 respectively). In those without contralateral abnormalities, hyperfiltration with mean eGFR of 149 ± 13 ml/min/1.73 m(2) was seen in 32% and proteinuria in 9.8%. There was a significantly inverse relationship between proteinuria and eGFR (p<0.0001). In conclusion, children with contralateral abnormalities are at risk for developing decreased kidney function, whereas a substantial number of patients with no obvious contralateral abnormalities have markers of renal injury. Therefore, systematic follow-up of all patients is recommended. PMID:21240528

Mansoor, Omer; Chandar, Jayanthi; Rodriguez, Maria M; Abitbol, Carolyn L; Seeherunvong, Wacharee; Freundlich, Michael; Zilleruelo, Gaston

2011-04-01

7

Case report: ultrasound-guided continuous thoracic paravertebral block for outpatient acute pain management of multilevel unilateral rib fractures.  

PubMed

A 61-year-old man with multiple unilateral rib fractures (T3-T8) gained the ability to breathe deeply and to ambulate after ultrasound-guided continuous thoracic paravertebral block and was discharged home after being observed for 15 hours after the block. The ultrasound guidance was helpful in determining the site of rib fractures and the optimal level for catheter placement. This report also discusses the management of analgesia using continuous paravertebral block in an outpatient with trauma. PMID:23223111

Murata, Hiroaki; Salviz, Emine Aysu; Chen, Stephanie; Vandepitte, Catherine; Hadzic, Admir

2013-01-01

8

[A case of congenital unilateral multicystic kidney with renal matrix calculi].  

PubMed

A forty-two-year-old man was seen with right lumbar pain. Physical examination revealed a right flank mass. Conventional excretory urography showed lack of right renal function, whereas left kidney was visualized. Right nephrectomy was performed. A cluster of several different sized cysts was disclosed in the right renal region. The renal surface was smooth. The removed kidney weighed 1,150 g. The ureter was completely obstructed at the ureteropelvic junction. Cysts were filled with matrix calculi. Pathological examination showed dysplastic glomeruli and primitive tubules within loose embryonic mesenchyme between two cysts whose walls consisted of smooth muscle strands and connective tissue. The final diagnosis was a congenital unilateral multicystic kidney with renal matrix calculi. The multicystic kidney is the most common form of renal cystic disease in infancy. However, few cases in adults have been reported. The diagnostic approach, treatment and outcome of a congenital unilateral multicystic kidney are discussed. PMID:3425523

Yamamoto, M; Miyake, K; Mitsuya, H; Ando, T; Natsume, H

1987-08-01

9

Unilateral ectopic right kidney, an incidental finding during pelvic sonogram.  

PubMed Central

An ectopic renal kidney was found incidentally during pelvic sonogram of a woman with incomplete abortion. The importance of pelvic ectopic kidney in obstetrics and gynecology and the significance of looking for a contralateral kidney before any pelvic surgery is embarked upon are discussed. A short review of significant differential diagnosis was also made. Images Figure 1 Figure 2 PMID:17052069

Dabiri, Luqman; Cheung, Wellman

2006-01-01

10

Management of Thoracal and Lumbar Schwannomas Using a Unilateral Approach without Instability: An Analysis of 15 Cases  

PubMed Central

Study Design Retrospective case series. Purpose The objectives of this study were to determine and discuss the surgical planning of patients who underwent operations following diagnoses of thoracal and lumbar spinal schwannomas. We also aimed to discuss the application of unilateral hemilaminectomy for the microsurgery of schwannomas. Overview of Literature Schwannomas are located in different regions and sites. These differences require several surgical approaches. Unilateral laminectomy without stabilization of the spine provides a more minimally invasive removal of the tumor. Methods In this retrospective study, 15 patients with spinal schwannomas were evaluated with regards to age, sex, onset history, neurological findings, tumor locations, McCormick scale, surgical procedure, and operational results. The lateral approach provides exposure of intradural structures and posterior paraspinal regions. Extensions of tumors cause problem for the surgeon in terms of approach, resectability of the tumor, and stability of the spine. Gross total resection was achieved in all cases, and none of the patients necessary required a fusion procedure. Results Five patients were males and 10 were females. The age interval was 29-65 years. The tumor was located in the lumbar region in 9 patients, in the thoracic region in 2 patients, and in the thoracolumbar junction in 4 patients. The intradural lesions were removed by laminectomy and the extradural lesions were resected with hemilaminectomy. The paramedian route was used to explore the extraspinal part of the tumor. Costotransversectomy was for the thoracic region. Subtotal resection was performed in 1 patient. Patient symptoms recovered gradually in the postoperative period. Conclusions Resection of giant schwannomas is challenging and usually requires a different approach. We describe the complete resection of complex dumbbell or paraspinal schwannomas of the thoracic and lumbar spine by unilateral hemilaminectomy. PMID:22439087

Canbay, Suat; Basmaci, Mehmet; Erten, Fuat; Harman, Ferhat

2012-01-01

11

Unilateral supernumerary kidney associated with hypertensive encephalopathy in a child  

Microsoft Academic Search

An afebrile 8-year-old boy presented with convulsions, coma and hypertension. Laboratory investigations were normal. Excretory urography and angiography showed a left supernumerary kidney. The literature on this rare anomaly is briefly reviewed.

F. Komolafe

1983-01-01

12

[Unilateral latero-thoracic exanthema in childhood. Clinical characteristics and diagnostic criteria in 5 patients].  

PubMed

Unilateral laterothoracic exanthem a (ULE) is a self-limited, probably infectious-allergic skin disease predominantly affecting small children. We describe five such cases. The typical unilaterally located or at least unilaterally dominant exanthem usually starts in the axillary region and is characterized by red, partly confluent papules and fine scales. Two of the children presented with atypical manifestations of ULE. Due to its asymptomatic course, therapy is not necessary in the majority of cases. PMID:10068930

Strom, K; Mempel, M; Fölster-Holst, R; Abeck, D

1999-01-01

13

Unilateral nephrectomy 24 hours after bilateral kidney irradiation reduces damage to the function and structure of the remaining kidney  

SciTech Connect

The effect of unilateral nephrectomy 24 h after irradiation on renal function and death with renal insufficiency as well as histopathological changes in the kidney was assessed. Single doses totaling 8-18 Gy were given bilaterally to unanesthetized female and male C3Hf/Kam mice. Renal function damage was assayed by blood urea nitrogen (BUN) and hematocrit (Hct). Histological damage was quantified by two parameters: kidney area and number of surviving tubule cells along the renal capsule. The number of glomeruli was scored as an indication of the number of nephrons. Changes in the two functional parameters did not appear sooner after irradiation in the nephrectomized mice than in the non-nephrectomized mice. Rather, less impairment of function was measured by both parameters in the nephrectomized mice but only after radiation doses greater than 12 Gy. The LD{sub 50} at 424 days after irradiation was also higher in the nephrectomized mice than in the mice receiving only irradiation, 13.98 Gy (95% confidence limits = 12.03, 15.93) and 11.71 Gy (95% confidence limits = 10.4, 13.1), respectively, in agreement with the data on function. Unilateral nephrectomy alone induced a 10% increase in size of the contralateral kidney. The dose-response curve for the kidney area from nephrectomized mice was parallel to and displaced above that for non-nephrectomized mice, indicating that the increase in renal mass occurred independent of and was not compromised by radiation. Unilateral nephrectomy alone induced no increase in the number of proximal tubules in the contralateral kidney. 30 refs., 9 figs., 1 tab.

Liao, Z.X.; Travis, E.L. [Univ. of Texas M.D. Anderson Cancer Center, Houston, TX (United States)

1994-09-01

14

Management and etiology of the unilateral multicystic dysplastic kidney: a review  

Microsoft Academic Search

In children, unilateral multicystic dysplastic kidney (MCDK) is one of the most frequently identified urinary tract abnormalities.\\u000a A variety of proposed etiologies has been associated with the underlying pathogenesis of MCDK. These include genetic disturbances,\\u000a teratogens, in utero infections, and urinary outflow tract obstruction. From 5–43% of the time, MCDK has associated genito-urinary\\u000a anomalies, both structural and functional in nature.

David S. Hains; Carlton M. Bates; Susan Ingraham; Andrew L. Schwaderer

2009-01-01

15

Autophagy regulates TGF-? expression and suppresses kidney fibrosis induced by unilateral ureteral obstruction.  

PubMed

Autophagy is an evolutionarily conserved process that cells use to degrade and recycle cellular proteins and remove damaged organelles. During the past decade, there has been a growing interest in defining the basic cellular mechanism of autophagy and its roles in health and disease. However, the functional role of autophagy in kidney fibrosis remains poorly understood. Here, using GFP-LC3 transgenic mice, we show that autophagy is induced in renal tubular epithelial cells (RTECs) of obstructed kidneys after unilateral ureteral obstruction (UUO). Deletion of LC3B (LC3(-/-) mice) resulted in increased collagen deposition and increased mature profibrotic factor TGF-? levels in obstructed kidneys. Beclin 1 heterozygous (beclin 1(+/-)) mice also displayed increased collagen deposition in the obstructed kidneys after UUO. We also show that TGF-?1 induces autophagy in primary mouse RTECs and human renal proximal tubular epithelial (HK-2) cells. LC3 deficiency resulted in increased levels of mature TGF-? in primary RTECs. Under conditions of TGF-?1 stimulation and autoinduction, inhibition of autolysosomal protein degradation by bafilomycin A1 increased mature TGF-? protein levels without alterations in TGF-?1 mRNA. These data suggest a novel intracellular mechanism by which mature TGF-?1 protein levels may be regulated in RTECs through autophagic degradation, which suppresses kidney fibrosis induced by UUO. The dual functions of TGF-?1, as an inducer of TGF-?1 autoinduction and an inducer of autophagy and TGF-? degradation, underscore the multifunctionality of TGF-?1. PMID:24854279

Ding, Yan; Kim, Sung Ll; Lee, So-Young; Koo, Ja Kun; Wang, Zhibo; Choi, Mary E

2014-12-01

16

Atrophy and Primary Somatosensory Cortical Reorganization after Unilateral Thoracic Spinal Cord Injury: A Longitudinal Functional Magnetic Resonance Imaging Study  

PubMed Central

The effects of traumatic spinal cord injury (SCI) on the changes in the central nervous system (CNS) over time may depend on the dynamic interaction between the structural integrity of the spinal cord and the capacity of the brain plasticity. Functional magnetic resonance imaging (fMRI) was used in a longitudinal study on five rhesus monkeys to observe cerebral activation during upper limb somatosensory tasks in healthy animals and after unilateral thoracic SCI. The changes in the spinal cord diameters were measured, and the correlations among time after the lesion, structural changes in the spinal cord, and primary somatosensory cortex (S1) reorganization were also determined. After SCI, activation of the upper limb in S1 shifted to the region which generally dominates the lower limb, and the rostral spinal cord transverse diameter adjacent to the lesion exhibited obvious atrophy, which reflects the SCI-induced changes in the CNS. A significant correlation was found among the time after the lesion, the spinal cord atrophy, and the degree of contralateral S1 reorganization. The results indicate the structural changes in the spinal cord and the dynamic reorganization of the cerebral activation following early SCI stage, which may help to further understand the neural plasticity in the CNS. PMID:24490171

Manxiu, Ma; Zhao, Can; Xi, Yue; Yang, Zhao-Yang; Li, Xiao-Guang

2013-01-01

17

Disproportionate inhibition of sodium reabsorption in the unilaterally diseased kidney of dog and man after an acute saline load  

PubMed Central

Clearance studies were performed on 49 split-bladder dogs with a unilateral pyelonephritic or remnant kidney and three patients with unilateral kidney disease to examine the effects of an acute saline load on the diseased kidney (DK) as opposed to a simultaneously studied, contralateral control kidney (CK), which also served to maintain a nonuremic environment. Before saline loading, base line studies in many of the dogs and the three humans were in agreement with previously published data. However, in dogs with a severe pyelonephritic lesion, a greater difference in DK vs. CK fractional excretion of sodium (FENa) and water was noted, whose magnitude was inversely correlated with the level of glomerular filtration rate (GFR) and maximum urine osmolality of DK compared to CK. An acute saline load (75 ml/kg) resulted in an inhibition of fractional sodium and water reabsorption in the diseased dog kidney which was disproportionately greater than in the simultaneously studied CK, regardless of the type or severity of the lesion. While mean DK GFR for all dogs increased 15% more than CK GFR, failure of FENa to increase after induction of a disproportionate increase in DK GFR with parathyroid hormone suggested that the saline-induced disproportionate increase in GFR was not solely responsible for the exaggerated inhibition of fractional sodium and water reabsorption in the diseased dog kidney. Studies in the three patients after saline loading (25 ml/kg) revealed a similar disproportionate resetting of glomerulotubular balance. Thus, regardless of base line function before expansion, the unilaterally diseased kidney of dog and man possesses unique characteristics in the absence of uremia which render it more reactive to the stimuli produced by acute saline loading. This suggests that the intrarenal environment of the kidney with a reduced nephron population may under some circumstances serve as a determinant of its function. Images PMID:5540177

Gutmann, Frank D.; Rieselbach, Richard E.

1971-01-01

18

Matched comparison of radical nephrectomy vs. nephron-sparing surgery in patients with unilateral renal cell carcinoma and a normal contralateral kidney  

Microsoft Academic Search

Objective: To report the long-term follow-up of a matched comparison of radical nephrectomy (RN) and nephron-sparing surgery (NSS) in patients with single unilateral renal cell carcinoma (RCC) and a normal contralateral kidney.Patients and Methods: Between August 1966 and March 1999, 1492 and 189 patients with unilateral RCC and a normal contralateral kidney underwent RN and NSS, respectively. Patients with renal

WKO Lau; ML Blute; AL Weaver; VE Torres; H Zincke

2002-01-01

19

Increased adenosine levels contribute to ischemic kidney fibrosis in the unilateral ureteral obstruction model  

PubMed Central

Renal interstitial fibrosis (RIF) occurs as a result of chronic kidney disease (CKD) and is a common pathway leading to end-stage renal failure. Renal tissue hypoxia and ischemia are present during CKD. Adenosine (ADO) is an important signaling molecule induced under ischemic and hypoxic conditions. In the present study, the association between ADO and RIF was investigated using a mouse model, with the aim of obtaining important information relevant to the prevention and treatment of RIF. A unilateral ureteral obstruction (UUO) model of RIF was established in mice. A total of 44 male mice were randomly divided into sham, model and intervention groups, and samples were collected on days 1, 3, 7, and 14 after modeling. These were collected to detect hypoxia and changes in ADO concentration in obstructed renal tissue as well as to analyze the pathological changes and degree of RIF in the renal tissue. Changes in the levels of collagen deposition and profibrogenic factors in renal tissues were analyzed following intervention with an ADO receptor blocker. Following the UUO procedure, continuous hypoxia was present in the obstructed renal tissue, accompanied by an increased ADO concentration. Tubular injury and interstitial fibrosis progressively increased over time following the UUO procedure. The mRNA expression levels of tissue tumor growth factor ?1 (TGF-?1) and ?1(I) procollagen were significantly increased. Subsequent to the ADO pathway being blocked by 8-(p-sulfophenyl)-theophylline, tubular injury and interstitial fibrosis were reduced and the expression of related cytokines was decreased. Increased ADO levels were induced by hypoxia, causing the development of RIF. Following the blocking of the ADO pathway, renal damage was deferred and renal functions were protected. PMID:25667621

TANG, JIN; JIANG, XIANZHEN; ZHOU, YIHONG; XIA, BING; DAI, YINGBO

2015-01-01

20

Chitosan/siRNA Nanoparticles Targeting Cyclooxygenase Type 2 Attenuate Unilateral Ureteral Obstruction-induced Kidney Injury in Mice  

PubMed Central

Cyclooxygenase type 2 (COX-2) plays a predominant role in the progression of kidney injury in obstructive nephropathy. The aim of this study was to test the efficacy of chitosan/small interfering RNA (siRNA) nanoparticles to knockdown COX-2 specifically in macrophages to prevent kidney injury induced by unilateral ureteral obstruction (UUO). Using optical imaging techniques and confocal microscopy, we demonstrated that chitosan/siRNA nanoparticles accumulated in macrophages in the obstructed kidney. Consistent with the imaging data, the obstructed kidney contained a higher amount of siRNA and macrophages. Chitosan-formulated siRNA against COX-2 was evaluated on RAW macrophages demonstrating reduced COX-2 expression and activity after LPS stimulation. Injection of COX-2 chitosan/siRNA nanoparticles in mice subjected to three-day UUO diminished the UUO-induced COX-2 expression. Likewise, macrophages in the obstructed kidney had reduced COX-2 immunoreactivity, and histological examination showed lesser tubular damage in COX-2 siRNA-treated UUO mice. Parenchymal inflammation, assessed by tumor necrosis factor-alpha (TNF-?) and interleukin 6 mRNA expression, was attenuated by COX-2 siRNA. Furthermore, treatment with COX-2 siRNA reduced heme oxygenase-1 and cleaved caspase-3 in UUO mice, indicating lesser oxidative stress and apoptosis. Our results demonstrate a novel strategy to prevent UUO-induced kidney damage by using chitosan/siRNA nanoparticles to knockdown COX-2 specifically in macrophages. PMID:25553102

Yang, Chuanxu; Nilsson, Line; Cheema, Muhammad Umar; Wang, Yan; Frøkiær, Jørgen; Gao, Shan; Kjems, Jørgen; Nørregaard, Rikke

2015-01-01

21

PDGF receptor kinase blocker AG1295 attenuates interstitial fibrosis in rat kidney after unilateral obstruction.  

PubMed

The current study was designed to investigate possible effects of the platelet-derived growth factor (PDGF) receptor kinase blocker AG1295 on the development of interstitial fibrosis in rats with unilateral ureteral obstruction (UUO), monitored by ED-A+ fibronectin expression, the number of macrophages, and the presence of myofibroblasts as visualized by immunohistochemistry with monoclonal antibodies (mAb) IST9, mAb ED1, and mAb 1A4, respectively; interstitial fibrosis was quantified by Sirius-Red staining and computer-aided image analysis. Without AG1295 treatment, the Sirius-Red stained area of the control kidneys comprised 6.8 +/- 1.3% of the totally inspected area and increased to 19.0 +/- 1.9% in animals by 14 days and to 23.4 +/- 1.7% by 21 days after UUO. The number of macrophages increased from 4.3 +/- 1.1 in controls to 16.6 +/- 2.6 in animals at 14 days and to 23.2 +/- 4.4 at 21 days after UUO. This was accompanied by an increase in both ED-A+ fibronectin deposition and alpha-smooth muscle actin expression. Treatment with AG1295 (12 mg/kg body weight, daily i.p.) significantly reduced interstitial fibrosis as verified by a smaller Sirius-Red stained area (15.7 +/- 1.9% in animals at 14 days and 17.0 +/- 0.7% at 21 days after UUO) and also by a reduced number of macrophages (12.8 +/- 1.4 in animals at 14 days and 15.5 +/- 3.8 at 21 days after UUO), and by the ED-A+ fibronectin deposition and the number of cells positive for alpha-smooth muscle actin. The study indicates that the PDGF receptor kinase blocker AG1295 is able to decrease interstitial fibrosis in the rat UUO model significantly. The diminution of early fibrosis mediators, i.e., macrophages, ED-A+ fibronectin, and myofibroblast phenotype, points to a modulated fibrosis process via a blockade of PDGF actions. PMID:10654073

Ludewig, D; Kosmehl, H; Sommer, M; Böhmer, F D; Stein, G

2000-01-01

22

Renal agenesis and unilateral nephrectomy: what are the risks of living with a single kidney?  

Microsoft Academic Search

The long-term outlook for patients with unilateral renal agenesis or following unilateral nephrectomy in childhood is controversial.\\u000a Animal studies suggest that the resultant compensatory increase in glomerular filtration might lead to progressive damage\\u000a to the remaining renal tissue and may generate hypertension. Human studies addressing these concerns are limited in number\\u000a and are difficult to interpret because they are small,

Shivaram Hegde; Malcolm G. Coulthard

2009-01-01

23

Pure laparoscopic unilateral nephrectomy for a patient with a polycystic horseshoe kidney  

PubMed Central

A 45-year-old female patient with autosomal dominant polycystic kidney disease (ADPKD) and a horseshoe kidney underwent right laparoscopic nephrectomy. The indication for nephrectomy was to create space within the right iliac fossa for renal transplantation. The operation proceeded as routine for laparoscopic nephrectomy for ADPKD, but was uniquely challenging due to the large size and extensive vasculature of the polycystic horseshoe kidney. In addition to documenting the feasibility of the pure laparoscopic approach for nephrectomy in patients with ADPKD and horseshoe kidney, this case highlights the abnormal location and vasculature encountered when operating on horseshoe kidneys. PMID:25485022

Dason, Shawn; Allard, Christopher B.; Shayegan, Bobby; Piercey, Kevin

2014-01-01

24

Renal Function and Solitary Kidney Disease: Wilms Tumour Survivors versus Patients with Unilateral Renal Agenesis  

Microsoft Academic Search

Aims: To test the hypothesis that Wilms tumour survivors (WTs) experience increased disturbance in renal function, even after prompt treatment, compared to patients with unilateral renal agenesis (URA). Methods: To assess the renal function of 30 WTs and 17 individuals with URA, the estimated glomerular filtration rate (eGFR) was calculated using the Schwartz and Filler formulas as well as the

Joanna Stefanowicz; Ewa Aleksandrowicz; Anna Owczarzak; Anna Balcerska

2012-01-01

25

PDGF receptor kinase blocker AG1295 attenuates interstitial fibrosis in rat kidney after unilateral obstruction  

Microsoft Academic Search

The current study was designed to investigate possible effects of the platelet-derived growth factor (PDGF) receptor kinase blocker AG1295 on the development of interstitial fibrosis in rats with unilateral ureteral obstruction (UUO), monitored by ED-A+ fibronectin expression, the number of macrophages, and the presence of myofibroblasts as visualized by immunohistochemistry with monoclonal antibodies (mAb) IST9, mAb ED1, and mAb 1A4,

Dirk Ludewig; Hartwig Kosmehl; Manfred Sommer; Frank-D. Böhmer; Günter Stein

2000-01-01

26

(99m)Tc Diethylenetriaminepentacetic Acid Angiotension-coverting Enzyme Inhibitor Renography as Screening Test for Renovascular Hypertension in Unilateral Small Kidney: A Prospective Study.  

PubMed

To know the probability of renal artery stenosis (RAS) in unilateral small kidney and function of the unilateral small kidney, which includes glomerular filtration rate, differential function, uptake, Tmax by (99m)Tc diethylenetriaminepentacetic acid (DTPA) base and (99m)Tc DTPA angiotensin converting enzyme (ACE) inhibition scan. All our patients were subjected to (99m)Tc DTPA ACE inhibition renal scintigraphy. All the patients underwent either computed tomography (CT) angiography and magnetic resonance (MR) angiography was done in those patients in which kidney function test was deranged. Renal angiography was subsequently performed in cases with the suggestion of RAS on CT or MR angiography. The quantitative data was expressed as the arithmetic mean, standard deviation and percentages. The intergroup comparisons for parametric data were done by Student's t-test, whereas non-parametric data was compared with Mann-Whitney U-test. The intergroup comparisons were made by paired t-test and Wilcoxon sign rank test. P <0.05 was considered to be significant, and data was analyzed by Statistical package for social sciences(SPSS-20) software. Out of 47 patients, 25 patients were in the low probability group out of which none was positive for RAS on CT/MR angiography. Out of 47 patients, 12 were in the intermediate group out of which none was positive for RAS. Ten, out of 47 patients were suspected of high probability for RAS by ACE inhibition scan out of which 4 were positive for RAS by CT/MR angiography including one with bilateral RAS. (99m)Tc DTPA angiotension-coverting enzyme inhibitor renography is a safe, non-invasive, sensitive, specific, and cost-effective test for excluding renovascular hypertension in patients who have normal or nearly normal renal function in unilateral small kidney. PMID:25538486

Ul Hassan, Masood; Khan, Shoukat H; Ashraf, Mohd; Najar, Saleem; Shaheen, Feroz

2014-09-01

27

Chronic unilateral ureteral obstruction in the neonatal mouse delays maturation of both kidneys and leads to late formation of atubular glomeruli  

PubMed Central

Unilateral ureteral obstruction (UUO) in the adult mouse is the most widely used model of progressive renal disease: the proximal tubule is the nephron segment most severely affected and atubular glomeruli are formed after only 7 days of UUO. To determine the proximal nephron response to UUO in the maturing kidney, neonatal mice were examined 7 to 28 days following complete UUO under general anesthesia. Proximal tubular mass and maturation were determined by staining with Lotus tetragolonobus lectin. Superoxide was localized by nitroblue tetrazolium and collagen by Sirius red. Cell proliferation, cell death, PAX-2, megalin, ?-smooth muscle actin (?-SMA), renin, and fibronectin were identified by immunohistochemistry. During the first 14 days of ipsilateral UUO, despite oxidative stress (4-hydroxynonenal staining), glomerulotubular continuity was maintained and mitochondrial superoxide production persisted. However, from 14 to 28 days, papillary growth was impaired and proximal tubules collapsed with increased apoptosis, autophagy, mitochondrial loss, and formation of atubular glomeruli. Fibronectin, ?-SMA, and collagen increased in the obstructed kidney. Oxidative stress was present also in the contralateral kidney: renin was decreased, glomerulotubular maturation and papillary growth were delayed, followed by increased cortical and medullary growth. We conclude that neonatal UUO initially delays renal maturation and results in oxidative stress in both kidneys. In contrast to the adult, proximal tubular injury in the neonatal obstructed kidney is delayed at 14 days, followed only later by the formation of atubular glomeruli. Antioxidant therapies directed at proximal tubular mitochondria during early renal maturation may slow progression of congenital obstructive nephropathy. PMID:24107422

Forbes, Michael S.; Thornhill, Barbara A.; Galarreta, Carolina I.; Minor, Jordan J.; Gordon, Katherine A.

2013-01-01

28

Electrodiagnostic confirmation of long thoracic nerve palsy  

Microsoft Academic Search

Long thoracic nerve latencies were measured in 25 normal subjects. The nerve was stimulated at Erb's point. Monopolar electrodes were used to record the motor evoked response from the serratus anterior muscle. The mean long thoracic nerve latency was 3.9 +\\/- 0.6 ms. Four athletes with unilateral, isolated long thoracic nerve palsies were compared with the control group and with

P E Kaplan

1980-01-01

29

Ring-Sp1 decoy oligonucleotide effectively suppresses extracellular matrix gene expression and fibrosis of rat kidney induced by unilateral ureteral obstruction.  

PubMed

Tubulointerstitial fibrosis is the consequence of an injury characterized by the accumulation of excess collagen and other extracellular matrix components, resulting in the destruction of the normal kidney architecture and subsequent loss of function. A transcription factor Sp1, originally described as a ubiquitous transcription factor, is involved in the basal expression of extracellular matrix genes and may, therefore, be important in fibrotic processes. Here, we report on the design of a ring-Sp1 decoy oligonucleotide, containing the consensus Sp1 binding sequence in a single decoy molecule without an open end, to create a novel therapeutic strategy for fibrosis. The ring-Sp1 decoy oligonucleotide is highly resistant to degradation by nucleases or serum compared to the conventional phosphorothioated double-stranded Sp1 decoy oligonucleotide, and effectively suppressed the expression of transforming growth factor-beta1 and fibronectin, the binding of Sp1 to the promoter region of these genes, and proliferation in response to serum in normal rat kidney fibroblasts. Moreover, treatment with the ring-Sp1 decoy in vivo significantly attenuates extracellular matrix gene expression in the rat kidney in which a unilateral ureteral obstruction had been induced. These results suggest that the ring-Sp1 decoy oligonucleotide represents promising therapeutic alternative to the conventional treatment of fibrotic disorders. PMID:16341057

Chae, Y-M; Park, K-K; Lee, I-K; Kim, J-K; Kim, C-H; Chang, Y-C

2006-03-01

30

Potentially modifiable risk factors for acute kidney injury after surgery on the thoracic aorta: a propensity score matched case-control study.  

PubMed

Perioperative risk factors were identified for acute kidney injury (AKI) defined by the RIFLE criteria (RIFLE = risk, injury, failure, loss, end stage) after surgery on the thoracic aorta with cardiopulmonary bypass (CPB) in this case-control study. A retrospective review was completed for 702 patients who underwent surgery on the thoracic aorta with CPB. A total of 183 patients with AKI were matched 1:1 with patients without AKI by a propensity score. Matched variables included age, gender, body-mass index, preoperative creatinine levels, estimated glomerular filtration rate, a history of hypertension, diabetes mellitus, cerebrovascular accident, smoking history, or chronic obstructive pulmonary disease to exclude the influence of patient demographics, preoperative medical status, and baseline renal function. Multivariate logistic regression analysis was used to evaluate for independent risk factors in the matched sample of 366 patients. The incidence of AKI was 28.6% and 5.9% of patients from the entire sample required renal replacement therapy. AKI was associated with a prolonged postoperative hospital stay and a higher one-month and one-year mortality both in the entire and matched sample set. Independent risk factors for AKI were a left ventricular ejection fraction <55%, preoperative hemoglobin level <10 g/dL, albumin <4.0 g/dL, diagnosis of dissection, operation time >7 hours, deep hypothermic circulatory arrest (DHCA) time >30 min, pRBC transfusion >1000 mL, and FFP transfusion >500 mL. Although the incidence of poor glucose control (blood glucose >180 mg/dL) was higher in patients with AKI in matched sample, it was not an independent risk factor.AKI was still associated with a poor clinical outcome in the matched sample. Potentially modifiable risk factors included preoperative anemia and hypoalbuminemia. Efforts to minimize operation time and DHCA time along with transfusion amount may protect patients undergoing aortic surgery against AKI. PMID:25590836

Kim, Won Ho; Park, Mi Hye; Kim, Hyo-Jin; Lim, Hyun-Young; Shim, Haeng Seon; Sohn, Ju-Tae; Kim, Chung Su; Lee, Sangmin M

2015-01-01

31

4:03 The growth of the thoracic spine in congenital scoliosis after expansion thoracoplasty  

Microsoft Academic Search

Purpose of study: Children with congenital thoracic scoliosis associated with fused ribs with unilateral unsegmented bars adjacent to convex hemivertebra will invariably have curve progression without treatment. The growth inhibition effects on the thoracic spine by surgery is said to be neglectable, because it is assumed that the concave side of such curves and the unilateral unsegmented bars do not

Robert Campbell; A. K. Hell-Vocke

2002-01-01

32

Unilateral perseveration.  

PubMed

The brain's action-intentional ("when") programming system helps to control when to and when not to initiate an action, when to persist at an action, and when to terminate an action. Motor perseveration is a failure to terminate an action. This disengagement disorder most often results from dysfunction of the executive frontal-subcortical networks that control the action-intentional programming system. Reports of unilateral perseveration are unusual. Here we describe a patient with a form of progressive supranuclear palsy (PSP) who exhibited continuous right-hand motor perseveration. This 68-year-old right-handed man had impaired walking and vertical gaze, consistent with PSP. He often repeated words, and on many motor tasks he showed continuous perseveration of his right but not his left hand. Unilateral motor perseveration may be a sign of PSP, the corticobasal syndrome, or a subtype of these disorders. Future studies of patients with both disorders should use tasks that assess for asymmetric hand perseveration. The mechanism of the unilateral perseveration must also be determined. Bilateral perseveration is found most often in patients with unilateral right frontal-subcortical (basal ganglia) or insula dysfunction. Because patients with PSP or corticobasal syndrome have callosal degeneration, their unilateral perseveration might result from a callosal disconnection of the right frontal lobe from the left hemisphere's premotor and motor as well as speech areas. PMID:24366105

Acosta, Lealani Mae Y; Goodman, Ira J; Heilman, Kenneth M

2013-12-01

33

Unilateral mediothoracic exanthem: a variant of unilateral laterothoracic exanthem.  

PubMed

We report the cases of a 4-year-old Chinese boy and a 33-year-old Chinese man with prodromal constitutional symptoms followed by eruption of small, painless, erythematous, papular lesions on relatively medial aspects of the anterior chest but not as far as the periflexural regions. Spontaneous remission was seen 2 and 3 weeks after rash onset in the child and the adult, respectively. We believe that the terms unilateral mediothoracic exanthem and unilateral thoracic exanthem are appropriate diagnostic labels. Such labels carry clinical significance as the patients can be reassured that although the rash may persist for weeks, final spontaneous remission with no complication is highly likely. Moreover, the risk of contagiousness is low, and we did not insist on isolation for prolonged periods. PMID:16475492

Chuh, Antonio A T; Chan, Henry H L

2006-01-01

34

Unilateral hydronephrosis  

MedlinePLUS

... out of the body into a drainage bag) Antibiotics for infections People who have only one kidney, who have immune system ... had a transplant will need prompt treatment. People who have ... antibiotics to reduce the risk of urinary tract infections.

35

[Renal unilateral oncocytis: case report].  

PubMed

The renal oncocytoma tumors are rare (5% of renal tumors). These benign tumors are incidentally diagnosed most often in an asymptomatic form. Sometimes it is multiple bilateral tumors affecting the renal parenchyma and forming a renal oncocytosis. We report the case of a unilateral right renal oncocytosis, very rare situation, characterized by a right renal parenchymal nodules with oncocytoma and a normal left kidney. PMID:24485085

Gryn, A; Roumiguié, M; Mazerolles, C; Bellec, L; Lagarde, S; Chauveau, D; Soulié, M; Beauval, J B

2014-02-01

36

Thoracic spine CT scan  

MedlinePLUS

CAT scan - thoracic spine; Computed axial tomography scan - thoracic spine; Computed tomography scan - thoracic spine; CT scan - ... your health care provider if you take the diabetes medication metformin (Glucophage).You may need to take ...

37

Thoracic aortic aneurysm  

MedlinePLUS

Aortic aneurysm - thoracic; Syphilitic aneurysm; Aneurysm - thoracic aortic ... The most common cause of a thoracic aortic aneurysm is hardening of the ... with high cholesterol, long-term high blood pressure, or who ...

38

Society of Thoracic Surgeons  

MedlinePLUS

... a Thoracic Surgeon? Adult Cardiac Surgery What is Pediatric Heart Disease? What is Risk Adjustment? Valve Repair/Replacement Surgery Esophageal Surgery Lung/Thoracic Surgery Aneurysm Surgery Arrhythmia Surgery Other Types of Surgery Clinical ...

39

Kidney Failure  

MedlinePLUS

... at Risk? Professional Education Advocacy Donate Kidney Disease Chronic Kidney Disease Kidney-Friendly Diet & Foods for CKD Polycystic Kidney Disease Kidney Failure End Stage Renal Disease Complication: Anemia Complication: Bone Disease Kidney Failure Treatment Kidney Problems ...

40

Isolated thoracic aortitis.  

PubMed

Isolated thoracic aortitis is a new pathological entity. We review the histopathological features of this disease, the role of imaging, and diagnostic modalities necessary to make the diagnosis of aortitis and discuss the management of patients with an established diagnosis of isolated thoracic aortitis. PMID:24345043

Omran, Nedal; Laco, Jan; Krbal, Lukas; Vojacek, Jan; Mandak, Jiri

2014-03-01

41

Acute adaptative changes to unilateral nephrectomy in humans  

Microsoft Academic Search

Acute adaptative changes to unilateral nephrectomy in humans. Renal function was monitored in 20, living–related kidney donors before and after uninephrectomy. Urinary protein excretion and retinoid metabolism respectively were studied in 10 and 6 of these donors. The functional adaptation was characterized by an increase in glomerular filtration rate and tubular function, which began in the first two days after

Angel Argiles; Georges Mourad; Nicole Basset; Jacques Haiech; Charles Mion; Jean Claude Cavadore; Jacques G Demaille

1987-01-01

42

Supernumerary kidney laparoscopically treated  

PubMed Central

Congenital anomalies of the kidney and urinary tract are part of a family of diseases with different anatomical origins. Duplicated collecting systems can be defined as a renal unit containing 2 pyelocalyceal systems associated with a single ureter or with double ureters. The supernumerary kidney is a definitive accessory organ with its own collecting system, blood supply, and distinct encapsulated parenchima. The true incidence of supernumerary kidney remains unknown, but most cases are in males, are unilateral and on the left side. We present a case of an adult woman with a hypoplastic supernumerary kidney with a complete ureteral duplication and an ectopic junction. The case has been laparoscopically treated. We demonstrate that a laparoscopic nephro-ureterectomy is feasible and that the management of the complication (urinoma and fistula) can be managed conservatively. PMID:24282475

Innocenzi, Michele; Casale, Paolo; Alfarone, Andrea; Ravaziol, Michele; Cattarino, Susanna; Grande, Pietro; Minisola, Francesco; Gentilucci, Alessandro; Gentile, Vincenzo; Sciarra, Alessandro

2013-01-01

43

Supernumerary kidney laparoscopically treated.  

PubMed

Congenital anomalies of the kidney and urinary tract are part of a family of diseases with different anatomical origins. Duplicated collecting systems can be defined as a renal unit containing 2 pyelocalyceal systems associated with a single ureter or with double ureters. The supernumerary kidney is a definitive accessory organ with its own collecting system, blood supply, and distinct encapsulated parenchima. The true incidence of supernumerary kidney remains unknown, but most cases are in males, are unilateral and on the left side. We present a case of an adult woman with a hypoplastic supernumerary kidney with a complete ureteral duplication and an ectopic junction. The case has been laparoscopically treated. We demonstrate that a laparoscopic nephro-ureterectomy is feasible and that the management of the complication (urinoma and fistula) can be managed conservatively. PMID:24282475

Innocenzi, Michele; Casale, Paolo; Alfarone, Andrea; Ravaziol, Michele; Cattarino, Susanna; Grande, Pietro; Minisola, Francesco; Gentilucci, Alessandro; Gentile, Vincenzo; Sciarra, Alessandro

2013-01-01

44

Thoracic outlet syndrome  

MedlinePLUS

... outlet syndrome is a rare condition that involves pain in the neck and shoulder, numbness and tingling of the fingers, and a weak grip. The thoracic outlet is the area between the rib cage and collar bone.

45

Thoracic Malignancy Steering Committee  

Cancer.gov

The Thoracic Malignancy Steering Committee evaluates and prioritizes concepts for phase 3 and large phase 2 therapeutic clinical trials to be conducted in the NCI National Clinical Trials Network (NCTN).

46

[Thoracic and abdominal wounds].  

PubMed

Thoracic and abdominal wounds are characterized by their diversity, their possible danger and the necessity of a successful diagnosis and therapy strategy. Management of thoracic wounds and indications of surgical treatment are conditioned by airway and hemodynamic states, paraclinical exams and chest drainage. The approach of abdominal wounds is based upon their possible penetrating character. Surgical indications, even if very discussed, are still wider. Thoraco-abdominal wounds could concern the diaphragm and are remarkable for their surgical strategy. PMID:9208685

Martinod, E; Lang-Lazdunski, L; Liard, O; Jancovici, R

1997-05-01

47

Thoracic Malignancy Steering Committee  

Cancer.gov

The TMSC functions to harmonize an efficient, cost-effective, science-driven, and transparent process that will identify and promote the "Best Science" in clinical research of lung and other thoracic malignancies by addressing the design and prioritization of phase III trials and large phase II studies in chest malignancies. In addition to focusing on lung cancer, the TMSC addresses oncology trials in other thoracic sites, such as mesothelioma. Esophageal cancer trials are reviewed by the Gastrointestinal Cancer Steering Committee.

48

Abnormal Growth and Clonal Proliferation of Fibroblasts in an Animal Model of Unilateral Ureteral Obstruction  

Microsoft Academic Search

The time course for the development of renal interstitial fibrosis (RIF) in rats between days 5 and 25 after unilateral ureteral obstruction (UUO) was studied. In kidneys with UUO under histological examination, an interstitial fibrosis was observed after more than 10 days with progression up to day 25. On day 5, collagen peptidase activity in homogenates of UUO kidneys was

Manfred Sommer; Robby Schaller; Reinhard Fünfstück; Adalbert Bohle; Frank D. Böhmer; Gerhard A. Müller; Günter Stein

1999-01-01

49

[Thoracic aortic aneurysm].  

PubMed

Thoracic aortic aneurysms (TAA) are the most common pathology of the thoracic aorta. TAA are occuring with increasing incidence (10.4 cases per 100,000 person years) and are most commonly caused by atherosclerosis. There are also hereditary, inflammatory and infectious pathogenic factors. A TAA initially causes no symptoms and is therefore usually diagnosed as an incidental finding. Computed tomography angiography (CTA) and magnetic resonance angiography (MRA) are the diagnostic tools of choice for diagnosis and treatment planning. The mean growth rate of TAA is estimated to be 0.10 to 0.42 cm per year. A diameter of 6 cm is considered to be an indication for surgery. Besides medicinal therapy, thoracic endovascular aortic repair (TEVAR) nowadays offers certain advantages compared to conventional open repair. The same applies to the region of the aortic arch. Follow up examinations after TEVAR are of major importance in order to ensure long-term therapeutic success. PMID:22476134

Kotelis, D; Geisbüsch, P; Hakimi, M; Böckler, D

2012-04-01

50

Understanding Thoracic Outlet Syndrome  

PubMed Central

The diagnosis of thoracic outlet syndrome was once debated in the world of vascular surgery. Today, it is more understood and surprisingly less infrequent than once thought. Thoracic outlet syndrome (TOS) is composed of three types: neurogenic, venous, and arterial. Each type is in distinction to the others when considering patient presentation and diagnosis. Remarkable advances have been made in surgical approach, physical therapy, and rehabilitation of these patients. Dedicated centers of excellence with multidisciplinary teams have been developed and continue to lead the way in future research. PMID:25140278

Freischlag, Julie

2014-01-01

51

Solitary Kidney  

MedlinePLUS

... Info Statistics Research Resources About Us Español National Kidney and Urologic Diseases Information Clearinghouse Publications Tools and ... List of Topics and Titles : Solitary Kidney Solitary Kidney On this page: What is a solitary kidney? ...

52

Kidney Transplant  

MedlinePLUS

... Rate Your Risk Quiz Featured Story African Americans & Kidney Disease Did you know that African Americans are ... KEEP Healthy - Free Kidney Health checks Featured Story Kidney Walk The Kidney Walk is the nation's largest ...

53

Ectopic Kidney  

MedlinePLUS

... Info Statistics Research Resources About Us Español National Kidney and Urologic Diseases Information Clearinghouse Publications Tools and ... List of Topics and Titles : Ectopic Kidney Ectopic Kidney On this page: What is an ectopic kidney? ...

54

Kidney Cysts  

MedlinePLUS

... fluid-filled sac. There are two types of kidney cysts. Polycystic kidney disease (PKD) runs in families. In PKD, the ... place of the normal tissue. They enlarge the kidneys and make them work poorly, leading to kidney ...

55

Kidney Dysplasia  

MedlinePLUS

... Info Statistics Research Resources About Us Español National Kidney and Urologic Diseases Information Clearinghouse Publications Tools and ... Z List of Topics and Titles : Kidney Dysplasia Kidney Dysplasia On this page: What is kidney dysplasia? ...

56

Kidney Biopsy  

MedlinePLUS

... Info Statistics Research Resources About Us Español National Kidney and Urologic Diseases Information Clearinghouse Publications Tools and ... Z List of Topics and Titles : Kidney Biopsy Kidney Biopsy On this page: What is a kidney ...

57

Bochdalek hernia with intrathoracic kidney.  

PubMed

Bochdalek hernia is a congenital diaphragmatic defect that allows abdominal viscera to herniate into the thorax. Intrathoracic kidney is a very rare finding representing less than 5% of all renal ectopias. A 20 year old female presented with complaints of dry cough since 15 days and intermittent fever of 4 days duration. As part of routine investigation chest X-ray was done which showed a left retro-cardiac homogenous opacity, rest of the lung field appeared normal. Abdominal ultrasound showed the right kidney to be normal, left kidney was not visualized. Computed tomography scan demonstrated left-sided Bochdalek hernia with the left kidney within the thorax. An IVP was done to confirm the diagnosis. Many a times intrathoracic kidney is confused with a thoracic mass and the patient undergoes a battery of unnecessary investigations, surgical interventions and image guided biopsies for the same, hence to avoid this we are reporting this case. PMID:23243354

Shah, Arti D; Ajay, Stani; Adalia, Mayur; Rathi, Amar

2012-10-01

58

Bochdalek hernia with intrathoracic kidney  

PubMed Central

Bochdalek hernia is a congenital diaphragmatic defect that allows abdominal viscera to herniate into the thorax. Intrathoracic kidney is a very rare finding representing less than 5% of all renal ectopias. A 20 year old female presented with complaints of dry cough since 15 days and intermittent fever of 4 days duration. As part of routine investigation chest X-ray was done which showed a left retro-cardiac homogenous opacity, rest of the lung field appeared normal. Abdominal ultrasound showed the right kidney to be normal, left kidney was not visualized. Computed tomography scan demonstrated left-sided Bochdalek hernia with the left kidney within the thorax. An IVP was done to confirm the diagnosis. Many a times intrathoracic kidney is confused with a thoracic mass and the patient undergoes a battery of unnecessary investigations, surgical interventions and image guided biopsies for the same, hence to avoid this we are reporting this case. PMID:23243354

Shah, Arti D.; Ajay, Stani; Adalia, Mayur; Rathi, Amar

2012-01-01

59

Unilateral hydronephrosis and renal damage after acute leukemia.  

PubMed

A 14-year-old boy presented with asymptomatic right hydronephrosis detected on routine yearly ultrasound examination. Previously, he had at least two normal renal ultrasonograms, 4 years after remission of acute myeloblastic leukemia, treated by AML-BFM-93 protocol. A function of the right kidney and no damage on the left was confirmed by a DMSA scan. Right retroperitoneoscopic nephrectomy revealed 3 renal arteries with the lower pole artery lying on the pelviureteric junction. Histologically chronic tubulointerstitial nephritis was detected. In the pathogenesis of this severe unilateral renal damage, we suspect the exacerbation of deleterious effects of cytostatic therapy on kidneys with intermittent hydronephrosis. PMID:22548083

Simanauskiene, Egle; Daugelaviciene, Valentina; Laurinavicius, Arvydas; Mickys, Ugnius; Simonyte, Vaida; Vaitkeviciene, Goda; Verkauskas, Gilvydas

2012-01-01

60

Unilateral Hydronephrosis and Renal Damage after Acute Leukemia  

PubMed Central

A 14-year-old boy presented with asymptomatic right hydronephrosis detected on routine yearly ultrasound examination. Previously, he had at least two normal renal ultrasonograms, 4 years after remission of acute myeloblastic leukemia, treated by AML-BFM-93 protocol. A function of the right kidney and no damage on the left was confirmed by a DMSA scan. Right retroperitoneoscopic nephrectomy revealed 3 renal arteries with the lower pole artery lying on the pelviureteric junction. Histologically chronic tubulointerstitial nephritis was detected. In the pathogenesis of this severe unilateral renal damage, we suspect the exacerbation of deleterious effects of cytostatic therapy on kidneys with intermittent hydronephrosis. PMID:22548083

Simanauskiene, Egle; Daugelaviciene, Valentina; Laurinavicius, Arvydas; Mickys, Ugnius; Simonyte, Vaida; Vaitkeviciene, Goda; Verkauskas, Gilvydas

2012-01-01

61

[Prenatal diagnostic of congenital unilateral hydronephrosis with megaureter--a case presentation].  

PubMed

Unilateral mild hydronephrosis with ureteral dilatation is a condition that can be detected by careful prenatal ultrasound examination. We present such a case, in a 26 year pregnant woman with hereditary antecedents (mother with Ombredan disease). The fetal ultrasound at 34 weeks indicated a left anechogenic sinuous image, identified as dilated ureter, and connected to a grade 2 hydronephrotic kidney. Normal data regarding the other kidney and the bladder made us recommend a close follow-up, considering this case as with a good prognosis. After birth, reassessment was favourable, and at 1 year follow-up the child was in good condition, and the kidney functional. We conclude that this case is a unilateral congenital megaureter, of probably obstructive origins, with a mild hydronephrosis. A good outcome was suggested by the late diagnostic, unilateral condition, and normal fetal ultrasound description regarding morphology, biometry and amniotic fluid. PMID:17438898

Socolov, R; Stratone, Carmen; Socolov, Demetra

2006-01-01

62

Vascular Thoracic Outlet Syndrome  

Microsoft Academic Search

  Abstract\\u000a \\u000a The surgical treatment of 30 cases of vascular thoracic outlet syndrome (TOS) in 25 patients is presented. Patients included\\u000a 17 women and 8 men with average age of 26.1 years. The causes of compression were cervical rib (n = 16), soft tissue anomalies (n = 12), and scar tissue after clavicle fracture (n = 2). Ten subclavian artery aneurysms

Lazar B. Davidovic; Dusan M. Kostic; Nenad S. Jakovljevic; Ilija L. Kuzmanovic; Tijana M. Simic

2003-01-01

63

Thoracic textilomas: CT findings*  

PubMed Central

OBJECTIVE: The aim of this study was to analyze chest CT scans of patients with thoracic textiloma. METHODS: This was a retrospective study of 16 patients (11 men and 5 women) with surgically confirmed thoracic textiloma. The chest CT scans of those patients were evaluated by two independent observers, and discordant results were resolved by consensus. RESULTS: The majority (62.5%) of the textilomas were caused by previous heart surgery. The most common symptoms were chest pain (in 68.75%) and cough (in 56.25%). In all cases, the main tomographic finding was a mass with regular contours and borders that were well-defined or partially defined. Half of the textilomas occurred in the right hemithorax and half occurred in the left. The majority (56.25%) were located in the lower third of the lung. The diameter of the mass was ? 10 cm in 10 cases (62.5%) and > 10 cm in the remaining 6 cases (37.5%). Most (81.25%) of the textilomas were heterogeneous in density, with signs of calcification, gas, radiopaque marker, or sponge-like material. Peripheral expansion of the mass was observed in 12 (92.3%) of the 13 patients in whom a contrast agent was used. Intraoperatively, pleural involvement was observed in 14 cases (87.5%) and pericardial involvement was observed in 2 (12.5%). CONCLUSIONS: It is important to recognize the main tomographic aspects of thoracic textilomas in order to include this possibility in the differential diagnosis of chest pain and cough in patients with a history of heart or thoracic surgery, thus promoting the early identification and treatment of this postoperative complication. PMID:25410842

Machado, Dianne Melo; Zanetti, Gláucia; Araujo, Cesar Augusto; Nobre, Luiz Felipe; Meirelles, Gustavo de Souza Portes; Pereira e Silva, Jorge Luiz; Guimarães, Marcos Duarte; Escuissato, Dante Luiz; Souza, Arthur Soares; Hochhegger, Bruno; Marchiori, Edson

2014-01-01

64

Nonintubated anesthesia for thoracic surgery  

PubMed Central

Nonintubated thoracic surgery has been used in procedures including pleura, lungs and mediastinum. Appropriate anesthesia techniques with or without sedation allow thoracic surgery patients to avoid the potential risks of intubated general anesthesia, particularly for the high-risk patients. However, nonintubated anesthesia for thoracic surgery has some benefits as well as problems. In this review, the background, indication, perioperative anesthetic consideration and management, and advantages and disadvantages are discussed and summarized. PMID:25589994

Wang, Bei

2014-01-01

65

Kidney School  

MedlinePLUS

... los módulos en español Introduction - Living Successfully with Kidney Disease People with kidney disease can live long ... online Download & print En Español Listen Module 1 - Kidneys: How They Work, How They Fail, What You ...

66

KIDNEY CANCER 15. KIDNEY CANCER  

E-print Network

KIDNEY CANCER 135 15. KIDNEY CANCER 15.1. SUMMARY Kidney cancer was the twelfth most common cancer of developing kidney cancer up to the age of 74 was 1 in 188 for women and 1 in 98 for men and was similar in NI and over, were alive up to 15 years after their kidney cancer diagnosis. Table 15.1 Summary information

Paxton, Anthony T.

67

Unilateral adrenal hemorrhage after total knee arthroplasty.  

PubMed

Adrenal hemorrhage (AH) is a rare but serious condition that is often diagnosed at autopsy. Unilateral adrenal hemorrhage (UAH) in adults is extremely rare and is often due to trauma or anticoagulation or is associated with systemic illness. The case of a 73-year-old man who was diagnosed with UAH several days after an elective total knee replacement is presented. The patient had an uncomplicated procedure and he was treated postoperatively with a prophylactic dose of subcutaneous low-molecular- weight heparin and compression sleeves. On postoperative day 8, he reported sustained epigastric and midback pain at the lower thoracic level. He had a temperature of 38.5°C. On clinical examination, the patient expressed only mild tenderness at the lumbar area. Abdominal ultrasound and computed tomography (CT) scan were inconclusive. On postoperative day 13, the patient experienced no pain but remained febrile. An abdominal CT scan revealed a high-density mass on the left adrenal gland suggestive of hemorrhage. The subcutaneous heparin as well as the antimicrobial therapy was discontinued and a serum cortisol examination was done. Serum levels were within normal values in the evening and the morning. On postoperative day 16, all laboratory values returned to normal and the patient was discharged in excellent condition. Patients who have abdominal pain, hypotension, or both soon after initiation of anticoagulation or patients who experience abdominal pain, fever, nausea, or confusion postoperatively should be screened for AH. PMID:24810831

Chronopoulos, Efstathios; Nikolaou, Vassilios S; Masgala, Aikaterini; Kaspiris, Angelos; Babis, Georgios C

2014-05-01

68

[Acute thoracic pain].  

PubMed

We report the case of a 56 year-old female patient without previous medical history presenting in the emergency room with acute left-sided thoracic pain and dyspnea. Initial lab exams, ECG and chest X-ray in supine position were normal and excluded most common pathologies, e.g. a large pneumothorax or myocardial infarction. A subsequent computed tomography to exclude an aortic dissection or pulmonary embolism showed left-sided sero-pneumothorax and mediastinal air. A spontaneous esophageal rupture (Boerhaave Syndrome) was diagnosed. An additional fluoroscopic study was performed to evaluate the exact site of rupture. PMID:17639965

Matt, D; Kubik-Huch, R A; Teufelberger, G; Knüsel, P R

2007-06-20

69

Thoracic spine x-ray  

MedlinePLUS

Vertebral radiography; X-ray - spine; Thoracic x-ray; Spine x-ray; Thoracic spine films; Back films ... The test is done in a hospital radiology department or in the health care provider's office. You will lie on the x-ray table in different positions. If the x-ray ...

70

[Thoracic findings in neurofibromatosis].  

PubMed

Neurofibromatosis type 1 (von Recklinghausen' disease) is an autosomal dominant hereditary syndrome. It is characterized with multiple light brown (café-au-lait) spots, Lisch nodules and neurofibromas. Thorax and lungs are affected in various forms. Four cases with symptoms of thoracic involvement were investigated in our clinic. Mean age was 46. All cases had dyspnoea and cough; two of them had chest pain. Skin lesions of neurofibromatosis type 1 (NF 1) were pathologically confirmed in all cases. Moreover, case 3 had diffuse interstitial fibrosis and honeycomb pattern. Case 2 had thorax deformity, kyphoscoliosis and intrathoracic benign mass. Case 1 had two neurofibrosarcoma masses on the right hemithorax. Case 4 had multiple intrathoracic neurofibromas. Cases 1 and 3 died within two years after diagnosis due to malignancy and respiratory failure, respectively. Cases 2 and 4 are still under our control. PMID:17001545

Camsari, Güngör; Gür, Aygün; Ozkan, Gülcihan; Bakan, Nur Dilek; Zengin, Fatma; Külcü, Ay?e

2006-01-01

71

Multicystic dysplastic kidney complicated by pyelonephritis  

PubMed Central

Patient: Female, 21 Final Diagnosis: Multicystic Dysplastic Kidney Disease complicated by pyelonephritis Symptoms: Left flank pain (CVAT) • dysuria • fever Medication: Levofloxacin Clinical Procedure: Dimercaptosuccinic acid scan • voiding cystouretrogram Specialty: Nephrology Objective: Rare disease Background: Multicystic dysplastic kidney (MCDK) is a renal dysplasia characterized by the presence of multiple cysts that are non-communicating, separated by dysplastic parenchyma that consumes the renal cortex resulting in a nonfunctional kidney. MCDK has an incidence of 1: 4300 of live births and is usually unilateral, most commonly occurring in the left kidney. Simple MCDK is defined as unilateral dysplasia with a normal contralateral kidney but with compensatory hypertrophy of the contralateral kidney, and no associated genitourinary anomalies. Case Report: A 21 year old Hispanic American female, presented with intermittent, sharp, severe left flank pain, fever and dysuria for two days but had gradually worsened within the last 24 hours prior to presentation. Previous history of multicystic dysplastic kidney, diagnosed four years ago. No pertinent physical examination findings except left costovertebral angle tenderness (CVAT). Urinalysis findings were positive for infection and urine culture grew pan sensitive Escherichia coli. A CT scan of abdominal and pelvis without contrast revealed a normal right kidney and left kidney had multiple non-communicating dilated cystic spaces, but no hydronephrosis, left ureteropelvic junction obstruction and finding were consistent with multicystic dysplastic kidney and also noted perinephric stranding. Conclusions: VUR is the most common renal abnormality in patients with MCDK, occurring in about 25% of contralateral kidney. Infections involving the MCDK are rare. In fact, cases of infections such as pyelonephritis or an infected renal cyst of MCDK are almost non-existent in the current literature. This patient presented with findings consistent with MCDK complicated by pyelonephritis. PMID:24349603

Cooper, Chad J.; Said, Sarmad; Khalillullah, Sayeed; Salameh, Hasan J.; Hernandez, German T.

2013-01-01

72

Kidney stones  

MedlinePLUS Videos and Cool Tools

... dissolved in the urine can crystallize, forming a kidney stone (renal calculus). Usually the calculus is the size ... painful. Often, people may not know they have kidney stones until they feel the painful symptoms resulting from ...

73

Kidney Diseases  

MedlinePLUS

Your kidneys are two bean-shaped organs, each about the size of your fists. They are located near the ... back, just below the rib cage. Inside each kidney about a million tiny structures called nephrons filter ...

74

Kidney Failure  

MedlinePLUS

Healthy kidneys clean your blood by removing excess fluid, minerals, and wastes. They also make hormones that keep your ... strong and your blood healthy. But if the kidneys are damaged, they don't work properly. Harmful ...

75

Unilateral posterior crossbite and mastication  

Microsoft Academic Search

ObjectiveThis study was designed to characterize masticatory-cycle morphology, and distance of the contact glide in the closing masticatory stroke, in adult subjects with uncorrected unilateral posterior crossbite (UPXB), comparing the results obtained with those obtained in a parallel group of normal subjects.

Benito Rilo; José Luis da Silva; María Jesús Mora; Carmen Cadarso-Suárez; Urbano Santana

2007-01-01

76

Thoracic Part of Sympathetic Chain and its Branching Pattern Variations in South Indian Cadavers  

PubMed Central

Introduction: The sympathetic trunks are two ganglionated nerve trunks that extend the whole length of the vertebral column.The two trunks end by joining together to form a single ganglion, the ganglion impar. The thoracic part of the sympathetic chain runs downward and leaves the thorax behind the medial arcuate ligament. The preganglionic fibers which are grouped together to forms planchnic nerves and supply the abdominal viscera. Anatomical variations of the thoracic sympathetic trunk in relation to intercostal nerves may be one of the reasons that cause surgical failures. Therefore, our present study aimed to investigate the sympathetic variations in the cadavers. Materials and Methods: In the present study we have investigated 31 embalmed cadavers thoracic cavities were eviscerated, the posterior thoracic walls were dissected carefully to expose the sympathetic chain and its branches. Results: Stellate ganglion was observed bilaterally in 4 cadavers and unilaterally in 15 cadavers. Greater splanchnic nerve highest origin was 4th ganglion and the lowest origin was 11th ganglion. Common origin for the lesser splanchnic nerve was from the 11th ganglion. Common origin for the least splanchnic nerves was from the 12th ganglion. Conclusion: Information on the variability of the anatomy of the thoracic sympathetic chain and splanchnic nerves may be important for the success of subdiaphragmatic neuroablative surgical approaches to pain control and splanchnic neurectomy for the management of chronic abdominal pain. PMID:25653929

Jothi, Swayam; Bapuji, P; Sree D, Lekha; Antony, Jacintha

2014-01-01

77

Acute minor thoracic injuries  

PubMed Central

ABSTRACT OBJECTIVE To review the management and follow-up of patients with minor thoracic injuries (MTI) treated by emergency or primary care physicians. DESIGN A multicentre, retrospective study. SETTING Three university-affiliated emergency departments of the metropolitan region of Quebec city, Que. PARTICIPANTS Patients older than 16 years of age with suspected or proven rib fractures following traumatic events. MAIN OUTCOME MEASURES Differences in admission and discharge proportions and disposition management following MTI. RESULTS Four hundred and forty-seven charts were analyzed. Only 23 patients (5.2%) were admitted during the study period. Admission and discharge proportions were significantly different among the 3 surveyed hospitals, ranging from 1.3% to 15.2% (P ? .001). There were no recommendations of follow-up noted in most (53.5%) of the charts and there were no differences after hospital stratification. Planned follow-up visits were scheduled for 5.7% of discharged patients. Being older than 65 years of age or having multiple rib fractures had no influence on management and follow-up recommendations. Eighty-two patients (18.6%) had unplanned follow-up visits in the emergency department, with inadequate pain relief as the principal reason for consultation (56.1%). There was no significant difference after stratification for age and type of analgesia. Other clinically significant delayed complications were recorded in 8.3% of all MTI patients. CONCLUSION The proportion of patients admitted for rib fractures was lower than the expected 25%, based on previous publications, and varied across surveyed hospitals. A very low proportion of patients was offered planned follow-up visits or even any follow-up recommendations in view of possible delayed complications and disabilities. Further studies are needed to identify predictors of delayed MTI complications and enhance appropriate use of follow-up resources. PMID:20228291

Shields, Jean-François; Émond, Marcel; Guimont, Chantal; Pigeon, Dany

2010-01-01

78

Renoprotective effects of telmisartan after unilateral renal ablation in rats  

PubMed Central

Purpose The renoprotective function of the angiotensin II type 1 receptor blocker (ARB) is well-known in various studies, including the animal model of renal failure. However, detailed temporal changes of pathological and molecular findings after unilateral nephrectomy are not fully understood. The main purpose of this study was to clarify the renoprotective effects and pathological changes induced by the ARB in rat-remnant kidney (RK) tissues after unilateral nephrectomy, but not after a 5/6 nephrectomy. Methods Telmisartan, which is structurally and functionally unique among ARB, was used in this study. Three rat groups were examined: A) no ARB administrated (RK, n=21); B) continuous subcutaneous infusion of an ARB administrated (RK-ARB, n=21); and C) a sham-operated group (Sham). Renal function was evaluated by blood urea nitrogen (BUN) levels and creatinine clearance (Ccr). Fibrosis was evaluated by hydroxyproline levels and Masson’s trichrome staining. Expressions of angiotensin II type 1 receptor (AT1R) and transforming growth factor beta (TGF-?) were investigated by real-time polymerase chain reaction and Western blotting. Results There was no significant difference regarding body and kidney weight or pathological features evaluated by hematoxylin and eosin staining between the RK and RK-ARB groups. The Ccr in the RK group was significantly lower than that in the Sham group (P<0.01), but no significant difference was found between the RK-ARB and Sham groups. The fibrotic area increased significantly with time after nephrectomy in the RK group. Although a similar trend was found in the RK-ARB group, the percentage of fibrous area in the RK-ARB group was significantly lower than that in the RK group at each time point (P<0.01). AT1R mRNA levels in the RK group were regulated immediately compared with those in the RK-ARB group. Although expressions of the AT1R and TGF-? were significantly higher in the RK-ARB group than in the Sham group, no significant differences were found between the RK-ARB and Sham group. Conclusion The ARB had renoprotective effects after unilateral nephrectomy. The ARB effectively maintained Ccr. Our results also showed the possibility that fibrotic changes mediated by AT1R and TGF-? play an important role in renal protection. Moreover, this is the first report on changes of AT1R expression after using the ARB telmisartan in kidney tissues after unilateral nephrectomy. Finally, our results suggest that ARB may be useful to prevent renal failure in patients treated with nephrectomy. PMID:24143119

Matsuo, Tomohiro; Miyata, Yasuyoshi; Sagara, Yuji; Higami, Yoshikazu; Tobu, Shohei; Matsuo, Manabu; Noguchi, Mitsuru; Shimokawa, Isao; Kanetake, Hiroshi; Sakai, Hideki

2013-01-01

79

Kidney Disease Basics  

MedlinePLUS

... Disease Children and Kidney Disease Additional Kidney Information Kidney Disease Basics Your kidneys filter extra water and ... blood pressure are the most common causes of kidney disease. These conditions can slowly damage the kidneys ...

80

[Operative risk in thoracic surgery].  

PubMed

Operative risk is encountered daily in thoracic surgery. Preoperatively, the risk can be evaluated by the pneumologist as well as the intensive care-surgery team. The parenchymal function and the patients respiratory capacity during the post-operative period should be evaluated. It is fundamental to evaluate heart function and vascular capacity. We discuss operative risk of dissection. The risk of bronchial fistulization is estimated at 5% (pneumonectomy) and 1% (lobectomy). Immediate complications include air leaks, rhythm disorders and post-operative bleeding. Thoracic drainage is a determining factor in thoracic surgery. The main problem remains post-operative respiratory failure especially since carcinological exeresis is usually carried out in patients with bronchopathies. PMID:7738132

Jancovici, R; Houel, R; Natali, F

1994-12-01

81

Managing advanced unilateral pseudoexfoliative glaucoma.  

PubMed

The only proven therapy for glaucoma is intraocular pressure (IOP) reduction, which can be accomplished by different means. Each should be properly discussed with patients in order to best preserve visual function and quality of life. We report a case of unilateral pseudoexfoliative glaucoma, treated for years with triple topical IOP-lowering drugs. The patient presented with advanced optic neuropathy and important ocular side effects secondary to the treatment. Having discussed his options and prognosis, laser trabeculoplasty was performed while maintaining the remaining therapy considering the advanced stage of glaucoma. His IOP was effectively reduced and no progression was noted after 1-year follow-up. Although medical therapy is the mainstream in glaucoma management, its side effects should not be ignored, especially in unilateral cases. Surgery might have been a better solution, but we chose to perform laser trabeculoplasty, an effective and safer alternative, considering the unlikely but serious risk of the "wipe-out phenomenon" in this case. PMID:24850557

Marques, André

2014-01-01

82

Surgical Sciences Cardiovascular Surgery, Thoracic Surgery ------------------------------------------------------  

E-print Network

38 Surgical Sciences Cardiovascular Surgery, Thoracic Surgery ------------------------------------------------------ http://ctstokyo.umin.ne.jp/ We are leading in Japan by annual surgery case volume of 700. New knowledge. ·Clinical research · Brain and spinal cord protection in thoracic aortic surgery · Minimally invasive

Miyashita, Yasushi

83

Kidney removal  

MedlinePLUS

Nephrectomy; Simple nephrectomy; Radical nephrectomy; Open nephrectomy; Laparoscopic nephrectomy; Partial nephrectomy ... cut is then closed with stitches or staples. Laparoscopic kidney removal: Your surgeon will make 3 or ...

84

Isolated Unilateral Absence of the Left Pulmonary Artery: A Case Report  

PubMed Central

We report the case of a 37-year-old man with isolated unilateral absence of the pulmonary artery (UAPA), which was diagnosed upon the occurrence of hemoptysis. Plain chest radiography demonstrated decreased left pulmonary volume. Computed tomography of the chest revealed the complete absence of the left pulmonary artery. Angiography revealed marked dilation of the left bronchial artery, inferior phrenic artery, internal thoracic artery, and the arterial branches of the thyrocervical trunk. These arteries were considered as collateral circulation to the left lung. In cases with UAPA, collateral circulation should be evaluated by angiography to obtain useful information for treatment. PMID:24995067

2014-01-01

85

Endovascular Repair of Thoracic Aortic Aneurysms  

PubMed Central

Degenerative aneurysms of the thoracic aorta are increasing in prevalence; open repair of descending thoracic aortic aneurysms is associated with high rates of morbidity and mortality. Repair of isolated descending thoracic aortic aneurysms using stent grafts was introduced in 1995, and in an anatomically suitable subgroup of patients with thoracic aortic aneurysm, repair with endovascular stent graft provides favorable outcomes, with decreased perioperative morbidity and mortality relative to open repair. The cornerstones of successful thoracic endovascular aneurysm repair are appropriate patient selection, thorough preprocedural planning, and cautious procedural execution, the elements of which are discussed here. PMID:22379281

Findeiss, Laura K.; Cody, Michael E.

2011-01-01

86

Kidney Cancer  

MedlinePLUS

You have two kidneys. They are fist-sized organs on either side of your backbone above your waist. The tubes inside filter and ... blood, taking out waste products and making urine. Kidney cancer forms in the lining of tiny tubes ...

87

Emergent Unilateral Renal Artery Stenting for Treatment of Flash Pulmonary Edema: Fact or Fiction?  

PubMed Central

Flash pulmonary edema is characteristically sudden in onset with rapid resolution once appropriate therapy has been instituted (Messerli et al., 2011). Acute increase of left ventricular (LV) end diastolic pressure is the usual cause of sudden decompensated cardiac failure in this patient population. Presence of bilateral renal artery stenosis or unilateral stenosis in combination with a single functional kidney in the susceptible cohort is usually blamed for this condition. We describe a patient who presented with flash pulmonary edema in the setting of normal coronary arteries. Our case is distinct as our patient developed flash pulmonary edema secondary to unilateral renal artery stenosis in the presence of bilateral functioning kidneys. Percutaneous stent implantation in the affected renal artery resulted in rapid resolution of pulmonary edema.

Khan, Asaad Akbar; McFadden, Eugene Patrick

2015-01-01

88

Differential renal function in unilateral renal injury: possible effects of radiopharmaceutical choice. [Rats  

SciTech Connect

An abnormal filtration fraction or a significant divergence between a kidney's ability to extract Tc-99m dimercaptosuccinic acid (DMSA) and other function parameters, such as the glomerular filtration rate (GFR) or the effective renal plasma flow (ERPF, could lead to different estimates of relative or absolute renal function, depending on the radiopharmaceutical administered. To evaluate this possible divergence, the authors measured the relative GFR (I-125 iothalamate), ERPF (I-131 hippurate), and Tc-99m DMSA accumulation in adult male Sprague-Dawley rats with unilateral ureteral obstruction or unilateral ischemia at various times after renal injury. The relative ERPF of the obstructed kidney was significantly greater than the relative GFR at all time periods studied; significant but less dramatic differences were noted comparing DMSA with GFR in obstruction and DMSA and ERPF with GRF in ischemia.

Taylor, A. Jr.; Lallone, R.

1985-01-01

89

Emergent unilateral renal artery stenting for treatment of flash pulmonary edema: fact or fiction?  

PubMed

Flash pulmonary edema is characteristically sudden in onset with rapid resolution once appropriate therapy has been instituted (Messerli et al., 2011). Acute increase of left ventricular (LV) end diastolic pressure is the usual cause of sudden decompensated cardiac failure in this patient population. Presence of bilateral renal artery stenosis or unilateral stenosis in combination with a single functional kidney in the susceptible cohort is usually blamed for this condition. We describe a patient who presented with flash pulmonary edema in the setting of normal coronary arteries. Our case is distinct as our patient developed flash pulmonary edema secondary to unilateral renal artery stenosis in the presence of bilateral functioning kidneys. Percutaneous stent implantation in the affected renal artery resulted in rapid resolution of pulmonary edema. PMID:25793128

Khan, Asaad Akbar; McFadden, Eugene Patrick

2015-01-01

90

Activation of Toll-like receptor 9 attenuates unilateral ureteral obstruction-induced renal fibrosis  

Microsoft Academic Search

Aim:To study whether activation of TLR9 by CpG-ODN would protect against and\\/or reverse renal fibrosis.Methods:Animals were treated with CpG-ODN before or after undergoing a unilateral ureteral obstruction (UUO) procedure. The interstitial fibrotic lesions of obstructed kidneys were evaluated using histology and immunohistostaining. The Th2-type cytokine profile and the expression and activity of sma and mad related protein (Smad)3, signal transducers

Bing-mu Xin; Xiao-xing Wang; Wen Jin; Hui-min Yan; Bing Cui; Xiao-wei Zhang; Fang Hua; Hong-zhen Yang; Zhuo-wei Hu

2010-01-01

91

Glomerular sclerosis in Wistar rats: analysis of its variable occurrence after unilateral nephrectomy.  

PubMed Central

Individual differences in susceptibility to the development of focal and segmental glomerular hyalinosis and sclerosis (FSGHS) were studied in rats after unilateral nephrectomy. A total of 20 male Wistar rats underwent unilateral nephrectomy at 3 months of age. Glomerular number in the removed kidney ranged from 17,000 to 32,700 with a mean value of 25,997 (n = 19). At death 30 weeks later, the incidence of glomeruli with FSGHS in the remaining kidney varied from 0 to 20% with a mean of 4.4%. However, the percentage of glomeruli with FSGHS and the degree of proteinuria did not correlate either with glomerular number per kidney (left and right kidneys were shown to be equivalent for glomerular number) or with glomerular volume on killing. The occurrence of FSGHS correlated significantly with mean protein excretion (P less than 0.01) and serum cholesterol levels (P less than 0.01). In conclusion, in the rat a relatively low number of nephrons in the kidneys does not increase susceptibility to the development of FSGHS. Images Fig. 3 PMID:3741773

Grond, J.; van Goor, H.; Erkelens, D. W.; Elema, J. D.

1986-01-01

92

Unilateral ureteral obstruction attenuates intrarenal angiotensin II generation induced by podocyte injury.  

PubMed

The renal tissue renin-angiotensin system is activated in chronic kidney diseases. We previously demonstrated that intrarenal ANG II is synthesized primarily from liver-derived angiotensinogen filtered through the glomerulus and that podocyte injury increases the passage of angiotensinogen into the tubular lumen and generation of ANG II. In the present study, we tested the effect of cessation of glomerular filtration by ureteral obstruction on renal ANG II generation in kidneys with podocyte injury under two experimental conditions. Ureteral obstruction is known to activate the renin-angiotensin system in nonproteinuric kidneys. Transgenic mice expressing hCD25 in podocyte (NEP25) were injected with 1.25 or 10 ng/g body wt of LMB2, a hCD25-targeted immunotoxin, subjected to unilateral ureteral ligation on the following day, and euthanized 7 and 4 days later, respectively. In both experiments, compared with the kidney in untreated wild-type mice, renal angiotensinogen protein, as assessed by immunostaining and Western blot analysis, was increased in the contralateral unobstructed kidney. However, it was markedly decreased in the obstructed kidney. Whereas intrarenal ANG II content was increased in the contralateral kidney compared with the untreated kidney (248 ± 83 vs. 106 ± 21 and 298 ± 185 vs. 64.8 ± 20 fmol/g kidney, respectively), this increase was suppressed in the obstructed kidney (161 ± 75 and 113 ± 34 fmol/g kidney, respectively), a pattern opposite to what we expected in obstructed kidneys without podocyte injury. Thus, our study indicates that the major source of increased renal ANG II in podocyte injury is filtered angiotensinogen. PMID:25673808

Okabe, Masahiro; Miyazaki, Yoichi; Niimura, Fumio; Pastan, Ira; Nishiyama, Akira; Yokoo, Takashi; Ichikawa, Iekuni; Matsusaka, Taiji

2015-04-15

93

Kidney disease - resources  

MedlinePLUS

Resources - kidney disease ... The following organizations are good resources for information on kidney disease: National Kidney Disease Education Program - www.nkdep.nih.gov National Kidney Foundation - www.kidney.org National ...

94

Testing for Kidney Disease  

MedlinePLUS

... and Kidney Disease Additional Kidney Information Testing for Kidney Disease Early kidney disease usually does not have signs ( ... how often you should be tested. Testing for Kidney Disease Overview Understanding GFR Understanding Urine Albumin Videos Testing ...

95

Chronic Kidney Diseases  

MedlinePLUS

... for a long time, doctors call it a chronic kidney disease. Children's kidney problems may be congenital (say: kun- ... Do Doctors Treat Kidney Problems? The treatment for chronic kidney ... bone disease. Sometimes unhealthy kidneys have problems producing a hormone ...

96

Pharmacokinetic optimization of immunosuppressive therapy in thoracic transplantation: part I  

PubMed Central

Although immunosuppressive treatments and therapeutic drug monitoring have significantly contributed to the increased success of thoracic transplantation, there is currently no consensus on the best immunosuppressive strategies. Maintenance therapy typically consists of a triple-drug regimen including corticosteroids, a calcineurin inhibitor (cyclosporine or tacrolimus) and either a purine synthesis antagonist (mycophenolate mofetil or azathioprine) or a mTOR inhibitor (sirolimus or everolimus). The incidence of acute and chronic rejection and of mortality after thoracic transplantation is still high compared to other types of solid organ transplantation. The high allogeneicity and immunogenicity of the lungs justify the use of higher doses of immunosuppressants, putting lung transplant recipients at a higher risk for drug-induced toxicities. All immunosuppressants are characterized by a large intra- and inter-individual variability of their pharmacokinetics and by a narrow therapeutic index. It is essential to know their pharmacokinetic properties and to use them for treatment individualization through therapeutic drug monitoring (TDM) in order to improve treatment outcome. Unlike the kidneys and the liver, the heart and the lungs are not directly involved in drug metabolism and elimination, which may be the cause of pharmacokinetic differences between patients from all these transplant groups. TDM is mandatory for most immunosuppressants, and has become an integral part of immunosuppressive drug therapy. It is usually based on trough concentrations (C0) monitoring, but other TDM tools include the area under the concentration-time curve over the dosing interval (AUC0-12) or over the first 4 hours post-dose (AUC0-4), as well as other single concentration-time points, such as the concentration 2 hours after dosing (C2). Given the peculiarities of thoracic transplantation, a review of the pharmacokinetics and TDM of the main immunosuppressants used in thoracic transplantation is presented in this article. Even more so than in other solid organ transplant populations, their pharmacokinetics is characterized by wide inter- and intra-individual variability in thoracic transplant recipients. The pharmacokinetics of cyclosporine in heart and lung transplant recipients has been explored in a number of studies, but less is known about that of mycophenolate and tacrolimus in these populations, while there are also hardly any studies on the pharmacokinetics of sirolimus and everolimus. Given the increased use of these molecules in thoracic transplant recipients, their pharmacokinetics deserves to be explored more in depth. There is very little data, some of which is conflicting, on the practices and outcomes of the TDM of immunosuppressants after thoracic transplantation. The development of sophisticated TDM tools dedicated to thoracic transplantation are awaited, in order to evaluate accurately and precisely patients’ exposure to drugs in general and in particular, to immunosuppre ssants. Finally, large cohort TDM studies definitely need to be conducted in thoracic transplant patients, in order to identify the most predictive exposure indices, and their target values, and to validate the clinical usefulness of improved TDM in these conditions. PMID:19691367

Monchaud, Caroline; Marquet, Pierre

2009-01-01

97

[Thoracic sympathectomy: treatment for hyperhidrosis].  

PubMed

Hyperhidrosis is a benign functional anomaly which is highly stressful for the patient. Active management is required. Several medical options are available but are often ineffective. The thoracic sympathic system plays a fundamental role in propagating stimulation of sudoral gland secretion. Endoscopic thoracic sympatecomy thus provides a radical treatment for severe palmar and axillary hyperhidrosis. We describe the technique used in our unit and present results and possible complications. This method has been used by many teams for several Years and despite some differences, most confirm major patient benefit. Phenomena of transferred sudation are frequent by are usually not invalidating. Patients should however be informed of this possibility because the effect is often irreversible. PMID:15133446

Arigon, J-P; Chapuis, O; Sainton, T; Rouquie, D; Bouchard, A; Brocq, F-X; Pons, F; Jancovici, R

2004-04-01

98

Kidney Problems  

MedlinePLUS

... result may be a higher risk of fluid imbalances, build-up of waste products, and other serious ... from kidney disease may include: Fluid and electrolyte imbalance – e.g., too much or too little sodium, ...

99

Thoracic spine sports-related injuries.  

PubMed

Although sports-related injuries to the thoracic spine are relatively uncommon, they are among the most feared due to the potential for catastrophic neurologic injury. The increased biomechanical support of the thoracic spine makes injuries in this region particularly rare compared with the cervical and lumbar spine. As a result, thoracic spine injuries can be missed easily, difficult to diagnose, and problematic to treat. Recognition of mechanism and awareness of injury patterns help physicians determine a diagnosis and create an index of suspicion for unstable thoracic spine injuries. Aggressive full-contact sports receive the most attention for spinal injury; however several sports with repetitive loading of the spine can cause severe injuries, including rowing, gymnastics, and golf. The goal of this article was to provide an overview of the unique anatomic and biomechanical features of the thoracic spine and to discuss some of the more common thoracic injuries that can affect athletes. PMID:25574880

Menzer, Heather; Gill, G Keith; Paterson, Andrew

2015-01-01

100

Metabolomics of renal venous plasma from individuals with unilateral renal artery stenosis and essential hypertension  

PubMed Central

Objective: To compare the metabolite profiles of venous effluent from both kidneys of individuals with unilateral atherosclerotic renal artery stenosis (ARAS) in order to directly examine how impaired renal blood flow impacts small-molecule handling in humans. Methods: We applied liquid chromatography–mass spectrometry based metabolite profiling to venous plasma obtained from the stenotic (STK) and contralateral (CLK) kidneys of ARAS patients (n?=?16), and both the kidneys of essential hypertensive controls (n?=?11). Study samples were acquired during a 3-day protocol that included iothalamate clearance measurements, radiographic kidney phenotyping (Duplex ultrasound, multidetector computed tomography, and blood-oxygen-level-dependent MRI), and controlled sodium and caloric intake and antihypertensive treatment. Results: Partial least squares-discriminant analysis demonstrated clear separation of essential hypertensive kidney metabolite profiles versus STK and CLK metabolite profiles, but no separation between metabolite profiles of STK and CLK samples. All of the discriminating metabolites were similarly elevated in the STK and CLK samples, likely reflecting the lower glomerular filtration rate in the ARAS versus essential hypertensive individuals (mean 66.1 versus 89.2?ml/min per 1.73?m2). In a paired analysis within the ARAS group, no metabolite was significantly altered in STK compared with CLK samples; notably, creatinine was the same in STK and CLK samples (STK/CLK ratio?=?1.0, P?=?0.9). Results were unchanged in an examination of ARAS patients in the bottom half of renal tissue perfusion or oxygenation. Conclusion: Metabolite profiling does not differentiate venous effluent from STKs or CLKs in individuals with unilateral ARAS, despite the measurable loss of kidney volume and blood flow on the affected side. These findings are consistent with the kidney's ability to adapt to ARAS to maintain a range of metabolic functions. PMID:25490710

Rhee, Eugene P.; Clish, Clary B.; Pierce, Kerry A.; Saad, Ahmed; Lerman, Lilach O.; Textor, Stephen C.

2015-01-01

101

Follistatin, an Activin Antagonist, Ameliorates Renal Interstitial Fibrosis in a Rat Model of Unilateral Ureteral Obstruction  

PubMed Central

Activin, a member of the TGF-? superfamily, regulates cell growth and differentiation in various cell types. Activin A acts as a negative regulator of renal development as well as tubular regeneration after renal injury. However, it remains unknown whether activin A is involved in renal fibrosis. To clarify this issue, we utilized a rat model of unilateral ureteral obstruction (UUO). The expression of activin A was significantly increased in the UUO kidneys compared to that in contralateral kidneys. Activin A was detected in glomerular mesangial cells and interstitial fibroblasts in normal kidneys. In UUO kidneys, activin A was abundantly expressed by interstitial ?-SMA-positive myofibroblasts. Administration of recombinant follistatin, an activin antagonist, reduced the fibrotic area in the UUO kidneys. The number of proliferating cells in the interstitium, but not in the tubules, was significantly lower in the follistatin-treated kidneys. Expression of ?-SMA, deposition of type I collagen and fibronectin, and CD68-positive macrophage infiltration were significantly suppressed in the follistatin-treated kidneys. These data suggest that activin A produced by interstitial fibroblasts acts as a potent profibrotic factor during renal fibrosis. Blockade of activin A action may be a novel approach for the prevention of renal fibrosis progression. PMID:24883308

Maeshima, Akito; Mishima, Keiichiro; Yamashita, Shin; Miya, Masaaki; Sakurai, Noriyuki; Sakairi, Toru; Hiromura, Keiju; Hasegawa, Yoshihisa; Kojima, Itaru; Nojima, Yoshihisa

2014-01-01

102

Follistatin, an activin antagonist, ameliorates renal interstitial fibrosis in a rat model of unilateral ureteral obstruction.  

PubMed

Activin, a member of the TGF-? superfamily, regulates cell growth and differentiation in various cell types. Activin A acts as a negative regulator of renal development as well as tubular regeneration after renal injury. However, it remains unknown whether activin A is involved in renal fibrosis. To clarify this issue, we utilized a rat model of unilateral ureteral obstruction (UUO). The expression of activin A was significantly increased in the UUO kidneys compared to that in contralateral kidneys. Activin A was detected in glomerular mesangial cells and interstitial fibroblasts in normal kidneys. In UUO kidneys, activin A was abundantly expressed by interstitial ?-SMA-positive myofibroblasts. Administration of recombinant follistatin, an activin antagonist, reduced the fibrotic area in the UUO kidneys. The number of proliferating cells in the interstitium, but not in the tubules, was significantly lower in the follistatin-treated kidneys. Expression of ?-SMA, deposition of type I collagen and fibronectin, and CD68-positive macrophage infiltration were significantly suppressed in the follistatin-treated kidneys. These data suggest that activin A produced by interstitial fibroblasts acts as a potent profibrotic factor during renal fibrosis. Blockade of activin A action may be a novel approach for the prevention of renal fibrosis progression. PMID:24883308

Maeshima, Akito; Mishima, Keiichiro; Yamashita, Shin; Nakasatomi, Masao; Miya, Masaaki; Sakurai, Noriyuki; Sakairi, Toru; Ikeuchi, Hidekazu; Hiromura, Keiju; Hasegawa, Yoshihisa; Kojima, Itaru; Nojima, Yoshihisa

2014-01-01

103

At Risk for Kidney Disease?  

MedlinePLUS Videos and Cool Tools

... Kidney Disease Additional Kidney Information At Risk for Kidney Disease? You are at risk for kidney disease ... failure by treating kidney disease early. Diabetes and Kidney Disease Diabetes is the leading cause of kidney ...

104

Prepubertal Unilateral Gynecomastia: Report of 2 Cases  

PubMed Central

Prepubertal unilateral gynecomastia is an extremely rare condition. At present, its etiology and management strategy are not well known. Two unrelated prepubertal boys of ages 8 and 9 who presented with complaints of unilateral enlargement of breast tissue are reported. Physical examination, biochemical, hormonal and oncologic work-up findings were normal. Both patients were treated with peripheral liposuction successfully. Histopathological and immunohistochemical examinations showed benign fibroglandular gynecomastia and intensive (3+) estrogen receptor expression in 100% of periductal epithelial cells. Although an extremely rare and generally benign condition, patients with prepubertal unilateral gynecomastia should have a full endocrine and oncologic work-up. PMID:25541897

Demirbilek, Hüseyin; Bacak, Gökhan; Baran, R?za Taner; Avc?, Yahya; Baran, Ahmet; Kele?, Ay?enur; Özbek, Mehmet Nuri; Alanay, Yasemin; Hussain, Khalid

2014-01-01

105

Postural disturbances resulting from unilateral and bilateral diaphragm contractions: a phrenic nerve stimulation study.  

PubMed

Thoracoabdominal breathing movements are a complex source of postural disturbance, but there are contradictory reports in the literature with inspiration described as having either a backward or a forward disturbing effect. To elucidate the mechanisms underlying this phenomenon, the present study studied the postural disturbance caused by isolated contractions of the diaphragm. Eight male and four female healthy subjects followed an original paradigm of phrenic nerve stimulation (bilateral and unilateral) and "diaphragmatic" voluntary sniff maneuvers in the seated and standing postures. Center of gravity (CG) acceleration was calculated from force plate recordings, and respiratory kinematics were assessed with thoracic and abdominal sensor belts. CG and respiratory signals revealed that, while seated, bilateral phrenic stimulation and sniff maneuvers consistently produced expansion of the abdomen associated with a forward peak of CG acceleration. In the standing posture, the direction of the CG peak was reversed and always directed backward. Unilateral phrenic stimulation induced an additional medial-lateral acceleration of the CG, directed toward the nonactive side while seated, but in the opposite direction while standing. These results suggest that isolated diaphragmatic contractions produce a constant disturbing pattern for a given posture, but with opposite effects between standing and seated postures. This could be related to the different biomechanical configuration of the body in each posture, corresponding to distinct kinematic patterns of the osteoarticular chain. In addition, the lateral component of the CG acceleration induced by unilateral diaphragm contractions could be clinically relevant in patients with hemidiaphragm paralysis. PMID:25150226

Hamaoui, Alain; Hudson, Anna L; Laviolette, Louis; Nierat, Marie-Cécile; Do, Manh-Cuong; Similowski, Thomas

2014-10-15

106

Kidney Stones  

NSDL National Science Digital Library

This patient education program discusses kidney stones including how they are formed, their symptoms, diagnosis, treatment options, and prevention. It also reviews the anatomy and function of the kidneys. This resource is a MedlinePlus Interactive Health Tutorial from the National Library of Medicine, designed and developed by the Patient Education Institute. NOTE: This tutorial requires a special Flash plug-in, version 4 or above. If you do not have Flash, you will be prompted to obtain a free download of the software before you start the tutorial. You will also need an Acrobat Reader, available as a free download, in order to view the Reference Summary.

Patient Education Institute

107

Proteinuria, hypertension and chronic renal failure in X-linked Kallmann's syndrome, a defined genetic cause of solitary functioning kidney  

Microsoft Academic Search

type, renal agenesis, the kidney is absent (2). In an Background. Anosmia and hypogonadotrophic hypo- autopsy study of 9200 individuals dying of incidental gonadism are the classic features of X-linked causes, unilateral agenesis was noted in seven (3), Kallmann's syndrome, a disorder caused by mutations whereas another, radiological, series identified no renal of KAL, a gene expressed during kidney and

Veronique Duke; Richard Quinton; Isky Gordon; Pierre M. G. Bouloux; Adrian S. Woolf

108

Organ Facts: Kidney / Pancreas  

MedlinePLUS

... Lung Kidney Pancreas Kidney/Pancreas Liver Intestine Kidney/Pancreas Facts The kidneys are a pair of reddish- ... the chemical (electrolyte) composition of the blood. The pancreas is a five to six inch gland located ...

109

About Chronic Kidney Disease  

MedlinePLUS

... Rate Your Risk Quiz Featured Story African Americans & Kidney Disease Did you know that African Americans are ... KEEP Healthy - Free Kidney Health checks Featured Story Kidney Walk The Kidney Walk is the nation's largest ...

110

Diabetes and Kidney Disease  

MedlinePLUS

... Rate Your Risk Quiz Featured Story African Americans & Kidney Disease Did you know that African Americans are ... KEEP Healthy - Free Kidney Health checks Featured Story Kidney Walk The Kidney Walk is the nation's largest ...

111

National Kidney Foundation  

MedlinePLUS

... Rate Your Risk Quiz Featured Story African Americans & Kidney Disease Did you know that African Americans are ... KEEP Healthy - Free Kidney Health checks Featured Story Kidney Walk The Kidney Walk is the nation's largest ...

112

E-Kidney Newsletter  

MedlinePLUS

... Rate Your Risk Quiz Featured Story African Americans & Kidney Disease Did you know that African Americans are ... KEEP Healthy - Free Kidney Health checks Featured Story Kidney Walk The Kidney Walk is the nation's largest ...

113

Diet and Kidney Stones  

MedlinePLUS

... Rate Your Risk Quiz Featured Story African Americans & Kidney Disease Did you know that African Americans are ... KEEP Healthy - Free Kidney Health checks Featured Story Kidney Walk The Kidney Walk is the nation's largest ...

114

Kidney-Pancreas Transplant  

MedlinePLUS

... Rate Your Risk Quiz Featured Story African Americans & Kidney Disease Did you know that African Americans are ... KEEP Healthy - Free Kidney Health checks Featured Story Kidney Walk The Kidney Walk is the nation's largest ...

115

Pregnancy and Kidney Disease  

MedlinePLUS

... Rate Your Risk Quiz Featured Story African Americans & Kidney Disease Did you know that African Americans are ... KEEP Healthy - Free Kidney Health checks Featured Story Kidney Walk The Kidney Walk is the nation's largest ...

116

Polycystic kidney disease  

MedlinePLUS

Cysts - kidneys; Kidney - polycystic; Autosomal dominant polycystic kidney disease; ADPKD ... Polycystic kidney disease (PKD) is passed down through families (inherited), usually as an autosomal dominant trait. If one parent ...

117

Simple Kidney Cysts  

MedlinePLUS

... Info Statistics Research Resources About Us Español National Kidney and Urologic Diseases Information Clearinghouse Publications Tools and ... of Topics and Titles : Simple Kidney Cysts Simple Kidney Cysts On this page: What are simple kidney ...

118

Medullary Sponge Kidney  

MedlinePLUS

... Info Statistics Research Resources About Us Español National Kidney and Urologic Diseases Information Clearinghouse Publications Tools and ... Topics and Titles : Medullary Sponge Kidney Medullary Sponge Kidney On this page: What is medullary sponge kidney? ...

119

HIV and Kidney Disease  

MedlinePLUS

... Select a Language: Fact Sheet 651 HIV and Kidney Disease WHY SHOULD PEOPLE WITH HIV CARE ABOUT KIDNEY ... disease. Kidney problems can lead to end-stage renal disease (ESRD) or kidney failure. This can require dialysis ...

120

Thoracic duct opacification for CT scanning  

SciTech Connect

High-resolution CT scanners image mediastinal structures well. It is often helpful, especially in the abnormal mediastinum, to opacify vascular structures. CT scanning of the opacified and nonopacified normal thoracic duct has been reported. The authors describe a noninvasive method of opacifying the thoracic duct for CT scanning.

Day, D.L.; Warwick, W.J.

1985-02-01

121

36 CFR 223.236 - Unilateral termination.  

Code of Federal Regulations, 2010 CFR

...Forest Products Award of Contracts, Permits, Or Other Authorizing...unilaterally terminate a contract, permit, or other instrument...223.235(a); (2) Material breach or continued violation of the contract, permit or other...

2010-07-01

122

The Thoracic Shape of Hominoids  

PubMed Central

In hominoids, the broad thorax has been assumed to contribute to their dorsal scapular position. However, the dorsoventral diameter of their cranial thorax was found in one study to be longer in hominoids. There are insufficient data on thoracic shape to explain the relationship between broad thorax and dorsal scapular position. The current study presents data on multilevel cross-sectional shape and volume distribution in a range of primates. Biplanar radiographs of intact fluid-preserved cadavers were taken to measure the cross-sectional shape of ten equally spaced levels through the sternum (called decisternal levels) and the relative volume of the nine intervening thoracic segments. It was found that the cranial thorax of hominoids is larger and broader (except in the first two decisternal levels) than that of other primates. The cranial thorax of hominoids has a longer dorsoventral diameter because the increase in dorsoventral diameter caused by the increase in the volume of the cranial thorax overcompensates for the decrease caused by the broadening of the cranial thorax. The larger and broader cranial thorax in hominoids can be explained as a locomotor adaptation for scapular gliding and as a respiratory adaptation for reducing the effects of orthograde posture on ventilation-perfusion inequality. PMID:24818026

Chan, Lap Ki

2014-01-01

123

Peripapillary atrophy in the unilateral exfoliation syndrome  

Microsoft Academic Search

PurposeTo compare the areas of peripapillary atrophy between fellow eyes in patients with unilateral exfoliation syndrome.MethodsTopographic measurements for peripapillary atrophy and the optic nerve head with confocal scanning laser ophthalmoscopy, using the Heidelberg Retina Tomograph were performed on 45 nonglaucomatous patients with unilateral exfoliation syndrome. The area of peripapillary atrophy was divided into an alpha and a beta zone. The

Päivi Puska; Mika Harju; Ron Liebkind

2004-01-01

124

Unilateral pulmonary edema and acute rheumatic fever  

Microsoft Academic Search

Although the diagnostic criteria for acute rheumatic fever (ARF) are well known, a high index of suspicion is necessary in\\u000a order to assure timely diagnosis and appropriate treatment. We present a case of an 8-year-old child who presented with unilateral\\u000a pulmonary edema secondary to acute mitral insufficiency due to ARF. ARF should be considered in the differential diagnosis\\u000a of unilateral

John S. Giuliano Jr; Priya Sekar; Catherine L. Dent; William L. Border; Russel Hirsch; Peter B. Manning; Derek S. Wheeler

2008-01-01

125

Kidney Filtering  

NSDL National Science Digital Library

In this activity, students filter different substances through a plastic window screen, different sized hardware cloth and poultry netting. Their model shows how the thickness of a filter in the kidney is imperative in deciding what will be filtered out and what will stay within the blood stream.

2014-09-18

126

Kidney Stones  

MedlinePLUS

... when you urinate Your doctor will diagnose a kidney stone with urine, blood, and imaging tests. If you have a stone that won't pass on its own, you may need treatment. It can be done with shock waves; with ...

127

Kidney pain (image)  

MedlinePLUS

A kidney stone is a solid piece of material that forms in a kidney. Kidney stones may be the size of sand or ... A kidney stone is a solid piece of material that forms in a kidney. Kidney stones may be the ...

128

Kidney Disease of Diabetes  

E-print Network

Kidney Disease of Diabetes National Kidney and Urologic Diseases Information Clearinghouse The Burden of Kidney Failure Each year in the United States, more than 100,000 people are diagnosed with kidney failure, a serious condition in which the kidneys fail to rid the body of wastes.1 Kidney failure

Baker, Chris I.

129

Thoracic Extraosseous Epidural Cavernous Hemangioma  

PubMed Central

Cavernous hemangiomas were first reported in 1929 by Globus and Doshay, and are defined as benign vascular structures developed between the neural tissues occurring in the central nervous system, consisting of a dilated vascular bed. Cavernous hemangiomas comprise nearly 5-12% of all spinal vascular malformations; however, existence in the epidural space without bone involvement is rare. Only 4% of all cavernous hemangiomas (0.22/1.000.000) are purely epidural cavernous hemangiomas. In this case report, we removed a hemorrhagic thoracic mass presenting with progressive neurological deficits in a 55-year-old male patient. We found this case to be appropriate for presentation due to the rare occurrence of this type of cavernous hemangioma. PMID:25674348

Asil, Kiyasettin; Ceylan, Davut; Erdem, Sahin

2015-01-01

130

Thoracic extraosseous epidural cavernous hemangioma.  

PubMed

Cavernous hemangiomas were first reported in 1929 by Globus and Doshay, and are defined as benign vascular structures developed between the neural tissues occurring in the central nervous system, consisting of a dilated vascular bed. Cavernous hemangiomas comprise nearly 5-12% of all spinal vascular malformations; however, existence in the epidural space without bone involvement is rare. Only 4% of all cavernous hemangiomas (0.22/1.000.000) are purely epidural cavernous hemangiomas. In this case report, we removed a hemorrhagic thoracic mass presenting with progressive neurological deficits in a 55-year-old male patient. We found this case to be appropriate for presentation due to the rare occurrence of this type of cavernous hemangioma. PMID:25674348

Yaldiz, Can; Asil, Kiyasettin; Ceylan, Davut; Erdem, Sahin

2015-01-01

131

The thoracic surgical industrial complex.  

PubMed

The thoracic surgical industrial complex is an industry worth $2 billion per year and is shaped by six dominant forces, three positive and three negative. The three positive forces are technological innovation, entrepreneurial activity, and the flow of capital and the three opposing forces, government regulation, cost-containment, and the excessive costs of product liability insurance. We are now at a critical time in the evolution of this industry, with growth being enhanced in areas of lesser risk, namely, nonimplantable devices, at the expense of high-risk implantable devices. The future of the artificial heart hinges on the balance between the six forces, and this analysis examines the possibilities for timely development of this ultimate implantable device. PMID:3527091

Starr, A

1986-08-01

132

Kidney Disease  

Microsoft Academic Search

Crohn’s disease (CD) potentially affects many organs, including, albeit rarely, the kidney. The most frequent renal manifestations\\u000a are calcium oxalate stones and their complications; secondary amyloidosis; acute tubular necrosis related to volume depletion\\u000a caused by diarrheal fluid losses or inadequate fluid intake, or both. Tubulo-interstitial nephritis is another common finding\\u000a and, among patients with CD, the most common cause is

Margherita Rosa; Salvatore Giulio

133

Thoracic Wall Reconstruction in Advanced Breast Tumours  

PubMed Central

In advanced mammary tumours, extensive resections, sometimes involving sections of the thoracic wall, are often necessary. Plastic surgery reconstruction procedures offer sufficient opportunities to cover even large thoracic wall defects. Pedicled flaps from the torso but also free flap-plasties enable, through secure defect closure, the removal of large, ulcerated, painful or bleeding tumours with moderate donor site morbidity. The impact of thoracic wall resection on the respiratory mechanism can be easily compensated for and patients? quality of life in the palliative stage of disease can often be improved. PMID:24976636

Daigeler, A.; Harati, K.; Goertz, O.; Hirsch, T.; Behr, B.; Lehnhardt, M.; Kolbenschlag, J.

2014-01-01

134

Fractures of the Thoracic and Lumbar Spine  

MedlinePLUS

... thoracic and lumbar spine. At the accident scene, EMS rescue workers will ? rst check vital signs, ... of Orthopaedic Surgeons. Before moving the patient, the EMS team must immobilize the patient in a cervical ( ...

135

Detecting unilateral phrenic paralysis by acoustic respiratory analysis.  

PubMed

The consequences of phrenic nerve paralysis vary from a considerable reduction in respiratory function to an apparently normal state. Acoustic analysis of lung sound intensity (LSI) could be an indirect non-invasive measurement of respiratory muscle function, comparing activity on the two sides of the thoracic cage. Lung sounds and airflow were recorded in ten males with unilateral phrenic paralysis and ten healthy subjects (5 men/5 women), during progressive increasing airflow maneuvers. Subjects were in sitting position and two acoustic sensors were placed on their back, on the left and right sides. LSI was determined from 1.2 to 2.4 L/s between 70 and 2000 Hz. LSI was significantly greater on the normal (19.3±4.0 dB) than the affected (5.7±3.5 dB) side in all patients (p?=?0.0002), differences ranging from 9.9 to 21.3 dB (13.5±3.5 dB). In the healthy subjects, the LSI was similar on both left (15.1±6.3 dB) and right (17.4±5.7 dB) sides (p?=?0.2730), differences ranging from 0.4 to 4.6 dB (2.3±1.6 dB). There was a positive linear relationship between the LSI and the airflow, with clear differences between the slope of patients (about 5 dB/L/s) and healthy subjects (about 10 dB/L/s). Furthermore, the LSI from the affected side of patients was close to the background noise level, at low airflows. As the airflow increases, the LSI from the affected side did also increase, but never reached the levels seen in healthy subjects. Moreover, the difference in LSI between healthy and paralyzed sides was higher in patients with lower FEV1 (%). The acoustic analysis of LSI is a relevant non-invasive technique to assess respiratory function. This method could reinforce the reliability of the diagnosis of unilateral phrenic paralysis, as well as the monitoring of these patients. PMID:24718599

Fiz, José Antonio; Jané, Raimon; Lozano, Manuel; Gómez, Rosa; Ruiz, Juan

2014-01-01

136

The Effectiveness of Preemptive Thoracic Epidural Analgesia in Thoracic Surgery  

PubMed Central

Background. The aim of this study is to investigate the effectiveness of preemptive thoracic epidural analgesia (TEA) comparing conventional postoperative epidural analgesia on thoracotomy. Material and Methods. Forty-four patients were randomized in to two groups (preemptive: Group P, control: Group C). Epidural catheter was inserted in all patients preoperatively. In Group P, epidural analgesic solution was administered as a bolus before the surgical incision and was continued until the end of the surgery. Postoperative patient controlled epidural analgesia infusion pumps were prepared for all patients. Respiratory rates (RR) were recorded. Patient's analgesia was evaluated with visual analog scale at rest (VASr) and coughing (VASc). Number of patient's demands from the pump, pump's delivery, and additional analgesic requirement were also recorded. Results. RR in Group C was higher than in Group P at postoperative 1st and 2nd hours. Both VASr and VASc scores in Group P were lower than in Group C at postoperative 1st, 2nd, and 4th hours. Patient's demand and pump's delivery count for bolus dose in Group P were lower than in Group C in all measurement times. Total analgesic requirements on postoperative 1st and 24th hours in Group P were lower than in Group C. Conclusion. We consider that preemptive TEA may offer better analgesia after thoracotomy. PMID:24745020

Erturk, Engin; Aydogdu Kaya, Ferdane; Kutanis, Dilek; Besir, Ahmet; Akdogan, Ali; Geze, Sükran; Tugcugil, Ersagun

2014-01-01

137

A unique case of unilateral synophthalmia.  

PubMed

Developmental anomalies resulting in a single eye (cyclopia) or fusion of the eyes (synophthalmia) are rare. Examples of unilateral synophthalmia-in which there are 1 normal and 2 fused eyes from 3 anlagen in 2 orbits, 1 lateral proboscis, and 3 optic nerves-are even more rare. Herein, I report a unique fetus with unilateral synophthalmia that was not associated with a lateral proboscis but instead had an extra cerebral hemisphere. I postulate that the unilateral synophthalmia, accessory cerebral hemisphere, and minor structural abnormalities in the skull base were the result of failure in separating a monozygous twin, a situation similar to that postulated as the cause of fetus in fetu. PMID:20528261

Proia, Alan D

2011-01-01

138

Massive thoracic lipoma: a case report.  

PubMed

A 60-year-old woman with a massive left intra-thoracic lipoma presented with worsening dyspnea. A computed tomographic scan revealed an 18 x 10 x 24 cm intra-thoracic mass, which was compressing the left lung and shifting the mediastinum to the right. At operative resection, a large, well-encapsulated, intrathoracic lipoma was discovered that weighed 2,556 grams. Histologic evaluation confirmed that the mass consisted of benign adipose tissue. PMID:21675005

Morris, Lee M; Thurston, R Scott

2011-01-01

139

Kidney Failure  

NSDL National Science Digital Library

This patient education program discusses end-stage renal disease, or ESRD. It reviews how the kidneys work, signs and symptoms of problems, treatment options, and preventive measures. This resource is a MedlinePlus Interactive Health Tutorial from the National Library of Medicine, designed and developed by the Patient Education Institute. NOTE: This tutorial requires a special Flash plug-in, version 4 or above. If you do not have Flash, you will be prompted to obtain a free download of the software before you start the tutorial. You will also need an Acrobat Reader, available as a free download, in order to view the Reference Summary.

Patient Education Institute

140

Pregnancy in a unilaterally ovariohysterectomised queen.  

PubMed

A 4-year-old female Russian Blue cat presented with signs of right-sided abdominal distension, anorexia and a mucoid vaginal discharge. On the basis of clinical and ultrasonographical findings a tentative diagnosis of uterine torsion was made. Exploratory coeliotomy revealed a 900º right uterine torsion along the longitudinal axis. Unilateral ovariohysterectomy was performed. Subsequently, the cat had two successful and uneventful pregnancies. To our knowledge this is the first case report of pregnancy in a unilaterally ovariohysterectomised queen. PMID:25414240

Jurka, Piotr; Kacprzak, Kamil J; Degórska, Beata

2015-04-01

141

Recurrent unilateral vulval elephantiasis: a case report.  

PubMed

Genital elephantiasis is caused by a variety of infective and non infective causes leading to blockage of lymphatic. We are presenting a rare case of recurrent unilateral vulval elephantiasis which has recurred after initial reconstructive surgery. A 38 year old female presented with vulval swelling and on examination there was gross unilateral vulval enlargement. FNAC (Fine needle aspiration cytology) and biopsy were contributory for diagnosis. Patient was started with antibiotics and daily dressing was done till the infection was subsided and the patient was planned for reconstructive surgery. PMID:24971141

Muralidhar, Lakshmidevi; G, Sampath Kumar; Venkatesh, Shreedhar

2014-06-01

142

Anesthesia Management of a 20-Month-Old Patient with Giant Unilateral Wilms Tumor  

PubMed Central

Wilms tumour (WT) (or nephroblastoma) is one of the most common malignant kidney tumors in children. On subsequent stages clinically it is often characterized by abdominal hypertension syndrome, which, in turn, leads to development of respiratory insufficiency. Other symptoms comprise renal deficiency, hypertension, and abnormalities of hemostasis and hemogram. Treatment includes rounds of preoperative chemotherapy and subsequent surgery. We report a case of perioperative management for nephrectomy in 20-month-old patient with a giant unilateral WT. The complexity of anesthesia was determined by the size of tumor, increased intra-abdominal pressure, respiratory deficiency, and hypercoagulation.

Matinyan, Nune; Saltanov, Alexander; Martynov, Leonid; Kazantsev, Anatolij

2015-01-01

143

Chronic kidney disease, severe arterial and arteriolar sclerosis and kidney neoplasia: on the spectrum of kidney involvement in MELAS syndrome  

PubMed Central

Background MELAS syndrome (MIM ID#540000), an acronym for Mitochondrial Encephalopathy, Lactic Acidosis and Stroke-like episodes, is a genetically heterogeneous mitochondrial disorder with protean manifestations and occasional kidney involvement. Interest in the latter is rising due to the identification of cases with predominant kidney involvement and to the hypothesis of a link between mitochondrial DNA and kidney neoplasia. Case presentation We report the case of a 41-year-old male with full blown MELAS syndrome, with lactic acidosis and neurological impairment, affected by the "classic" 3243A > G mutation of mitochondrial DNA, with kidney cancer. After unilateral nephrectomy, he rapidly developed severe kidney functional impairment, with nephrotic proteinuria. Analysis of the kidney tissue at a distance from the two tumor lesions, sampled at the time of nephrectomy was performed in the context of normal blood pressure, recent onset of diabetes and before the appearance of proteinuria. The morphological examination revealed a widespread interstitial fibrosis with dense inflammatory infiltrate and tubular atrophy, mostly with thyroidization pattern. Vascular lesions were prominent: large vessels displayed marked intimal fibrosis and arterioles had hyaline deposits typical of hyaline arteriolosclerosis. These severe vascular lesions explained the different glomerular alterations including ischemic and obsolescent glomeruli, as is commonly observed in the so-called "benign" arteriolonephrosclerosis. Some rare glomeruli showed focal segmental glomerulosclerosis; as the patient subsequently developed nephrotic syndrome, these lesions suggest that silent ischemic changes may result in the development of focal segmental glomerulosclerosis secondary to nephron loss. Conclusions Nephron loss may trigger glomerular sclerosis, at least in some cases of MELAS-related nephropathy. Thus the incidence of kidney disease in the "survivors" of MELAS syndrome may increase as the support therapy of these patients improves. PMID:22353239

2012-01-01

144

Kidney cell electrophoresis  

NASA Technical Reports Server (NTRS)

A kidney cell electrophoresis technique is described in four parts: (1) the development and testing of electrophoresis solutions; (2) optimization of freezing and thawing; (3) procedures for evaluation of separated kidney cells; and (4) electrophoretic mobility characteristics of kidney cells.

Todd, P.

1979-01-01

145

Amyloidosis and Kidney Disease  

MedlinePLUS

... Info Statistics Research Resources About Us Español National Kidney and Urologic Diseases Information Clearinghouse Publications Tools and ... Failure Series : Amyloidosis and Kidney Disease Amyloidosis and Kidney Disease On this page: What is amyloidosis? What ...

146

Acquired Cystic Kidney Disease  

MedlinePLUS

... Info Statistics Research Resources About Us Español National Kidney and Urologic Diseases Information Clearinghouse Publications Tools and ... Failure Series : Acquired Cystic Kidney Disease Acquired Cystic Kidney Disease On this page: What is acquired cystic ...

147

Kidney Stones in Children  

MedlinePLUS

... Info Statistics Research Resources About Us Español National Kidney and Urologic Diseases Information Clearinghouse Publications Tools and ... of Topics and Titles : Kidney Stones in Children Kidney Stones in Children On this page: What is ...

148

Acute kidney failure  

MedlinePLUS

Kidney failure; Renal failure; Renal failure - acute; ARF; Kidney injury - acute ... There are many possible causes of kidney damage. They include: ... cholesterol (cholesterol emboli) Decreased blood flow due to very ...

149

Chronic Kidney Disease  

MedlinePLUS

You have two kidneys, each about the size of your fist. Their main job is to filter wastes and excess water out of ... help control blood pressure, and make hormones. Chronic kidney disease (CKD) means that your kidneys are damaged ...

150

Diabetic Kidney Problems  

MedlinePLUS

... too high. Over time, this can damage your kidneys. Your kidneys clean your blood. If they are damaged, waste ... in your blood instead of leaving your body. Kidney damage from diabetes is called diabetic nephropathy. It ...

151

Chronic kidney disease  

MedlinePLUS

Kidney failure - chronic; Renal failure - chronic; Chronic renal insufficiency; Chronic kidney failure; Chronic renal failure ... Chronic kidney disease (CKD) slowly gets worse over months or years. you may not notice any symptoms for some ...

152

Kidney Stones in Adults  

MedlinePLUS

... Info Statistics Research Resources About Us Español National Kidney and Urologic Diseases Information Clearinghouse Publications Tools and ... of Topics and Titles : Kidney Stones in Adults Kidney Stones in Adults On this page: What is ...

153

Kidney cell electrophoresis  

NASA Technical Reports Server (NTRS)

The following aspects of kidney cell electrophoresis are discussed: (1) the development and testing of electrophoresis solutions; (2) optimization of freezing and thawing; (3) procedures for evaluation of separated kidney cells; and (4) electrophoretic mobility characterization of kidney cells.

Todd, P.

1980-01-01

154

Polycystic Kidney Disease  

MedlinePLUS

... Z List of Topics and Titles : Polycystic Kidney Disease Polycystic Kidney Disease On this page: Autosomal Dominant PKD Autosomal Recessive ... Research Points to Remember For More Information Polycystic kidney disease (PKD) is a genetic disorder characterized by the ...

155

Chronic Kidney Disease  

MedlinePLUS

... well as they should. Normal, healthy kidneys remove waste from the blood. The waste then leaves your body in your urine. The ... have chronic kidney disease, your kidneys cannot remove waste from the blood as well as they should. ...

156

Peripheral nerve stimulation of the thoracic paravertebral plexus for chronic neuropathic pain.  

PubMed

Persistent post surgical pain is reported in 70% of patients following thoracotomy and mastectomy. This pain is often neuropathic in nature and occasionally it is refractory to traditional medical and interventional management. Neurostimulation of peripheral nerves can be a highly effective clinical modality for the management of neuropathic pain. The placement of a percutaneously sited electrode in the thoracic paravertebral plexus offers a new and novel mode of managing refractory thoracic neuropathic pain. We present 2 cases that demonstrate the effectiveness of this intervention in the long-term management of this clinical dilemma. The first case presented is that of a 61-year-old female, with unilateral neuropathic pain for 6 years following mastectomy refractory to traditional interventions. Targeted field stimulation of the thoracic paravertebral plexus resulted in significant improvement for 12 years. The second case is that of a 65-year-old male, with Type II diabetes with neuropathic thoracic pain for 6 years following multiple rib fractures (T4-T7) who responded positively to neurostimulation of the thoracic paravertebral plexus. Both of these cases demonstrate a relative reduction in pain intensity (> 80%), the elimination of oral analgesics, and improved functionality directly related to the novel use of this intervention. Effective and reproducible pain relief is achieved by specifically using a low frequency (10 Hz) and low amplitude (2 mA) stimulation technique. Equally important is that these cases highlight the increased risk of inadvertent pleural puncture with the development of a pneumothorax that can be associated with this intervention. Possible clinical, investigative and equipment modifications that need to be considered are discussed. The limitations include only 2 case reports, considered as the lowest level of evidence available in the era of evidence-based medicine, and lack of utilization of multiple other modalities of treatments utilized in managing neuropathic pain. In conclusion, these cases demonstrate the effectiveness of peripheral nerve stimulation of the thoracic paravertebral plexus in the long-term management of refractory neuropathic pain. They also serve to underline the importance of clinical awareness in order to improve patient safety. PMID:21587333

Hegarty, Dominic; Goroszeniuk, Teodor

2011-01-01

157

Modulation and Redistribution of Proteinase Inhibitor 8 (Serpinb8) during Kidney Regeneration  

Microsoft Academic Search

Background: The intracellular serpin, proteinase inhibitor 8 (PI8\\/Serpinb8), can inhibit furin, a prohormone convertase involved in inflammation, prohormone processing and extracellular matrix remodeling. Unilateral ureteral obstruction (UUO) is a well-characterized model of kidney disease associated with interstitial fibrosis, where recovery involves cellular proliferation and extracellular matrix remodeling. Given the presence of mouse PI8 (mPI8) in kidney, the UUO technique was

Anneliese Gillard; Kate Scarff; Kate L. Loveland; Sharon D. Ricardo; Phillip I. Bird

2006-01-01

158

Keep Your Kidneys Clear: Kicking Kidney Stones  

MedlinePLUS

Some say that passing a kidney stone is like delivering a baby made of razor blades. The good news is that, although they can be excruciatingly painful, kidney stones rarely cause permanent damage, and you may ...

159

UNILATERAL CONTACT OF ELASTIC BODIES (MOMENT THEORY)  

Microsoft Academic Search

Boundary contact problems of statics of the moment (couple- stress) theory of elasticity are studied in the case of a unilateral contact of two elastic anisotropic nonhomogeneous media. A problem, in which during deformation the contact zone lies within the boundaries of some domain, and a problem, in which the contact zone can extend, are given a separate treat- ment.

R. GACHECHILADZE

2001-01-01

160

Influence of Thoracic Flexion Syndrome on Proprioception in the Thoracic Spine  

PubMed Central

[Purpose] This study was performed to determine the difference in thoracic repositioning sense in young people with and without thoracic flexion syndrome (TFS) in target positions of half extension. [Subjects] People with TFS (n = 15; 7 men and 8 women) and people without TFS (n = 15; 7 men and 8 women) were recruited from three universities. Subjects were guided into a sitting extension target posture and were asked to move from a neutral position (2?s) to an extension target position (2?s); 10 trials were performed. [Results] People with TFS showed a significantly higher thoracic repositioning error in the extension target position than people without TFS. [Conclusion] People with TFS show a higher thoracic spine repositioning error in extension than people without TFS. A rehabilitation program to treat TFS should be implemented for individuals with decreased position sense of the thoracic spine. PMID:25364109

Park, Kyue-Nam; Oh, Jae-Seop

2014-01-01

161

Multidisciplinary Treatment for Thoracic and Abdominopelvic Endometriosis  

PubMed Central

Background and Objectives: Thoracic endometriosis is a rare form of extragenital endometriosis with important clinical ramifications. Up to 80% of women with thoracic endometriosis have concomitant abdominopelvic endometriosis, yet the surgical treatment is usually performed with separate procedures. This is the largest published series of the combination of video-assisted thoracoscopic surgery and traditional laparoscopy for the treatment of abdominopelvic and thoracic endometriosis. The objectives of this series are to further evaluate the manifestations of thoracic endometriosis, assess the multidisciplinary surgical approach, and discuss our institution's protocols. Methods: This is a retrospective, institutional review board–approved case series of 25 consecutive women who underwent combined video-assisted thoracoscopic surgery and traditional laparoscopy for the treatment of abdominopelvic, diaphragmatic, and thoracic endometriosis from January 1, 2008, to September 30, 2013. All surgeries were performed at a tertiary referral center by the same primary surgeons. Data were collected by chart review. Results: Twenty-five patients were included, with a mean age of 37.7 years. Eighty percent of patients had catamenial chest pain, and in 40% this was their only chest complaint. Shoulder pain was noted in 40% of patients, catamenial pneumothorax in 24%, and hemoptysis in 12%. One hundred percent of patients were found to have endometriosis in the pelvis, 100% in the diaphragm, 64% in the chest wall, and 40% in the parenchyma. There were 2 major postoperative complications: 1 diaphragmatic hernia and 1 vaginal cuff hematoma. Conclusion: Clinical suspicion and preoperative assessment are crucial in the diagnosis of thoracic endometriosis and allow for a multidisciplinary approach. The combination of video-assisted thoracoscopic surgery and traditional laparoscopy for the treatment of endometriosis optimally addresses the pelvis, diaphragm, and thoracic cavity in a single operation. PMID:25392636

Main, Jillian; Paka, Chandhana; Nezhat, Azadeh; Beygui, Ramin E.

2014-01-01

162

Thoracic fraction of inhaled fiber aerosol.  

PubMed

Size-selective sampling is a health-related method to collect airborne particles based on penetration of inhaled particles into different regions of the human respiratory tract; thus, it is the most relevant sampling method to correlate health risks with occupational exposure. The current practice of sampling asbestos and other fibers is not a size-selective method. The thoracic size fraction, defined as the portion of inhaled particles that can penetrate through the larynx, has been suggested as the most relevant size-selective sampling method for fiber aerosol. The thoracic fraction is based on 1-deposition of inhaled spherical particles in the human extrathoracic airways for mouth breathing and corrected for the particle inhalability. There is no comparable information for fiber aerosols; therefore, there is no technical basis to ascertain whether the current thoracic fraction definition is suitable for fiber aerosols. No human data are available from controlled experiments of inhaled fiber aerosols for the obvious reason that most fiber materials are potentially hazardous when inhaled. Our approach was to measure penetration of fiber aerosol in realistic human oropharyngeal airway replicas and to compare that with data from spherical particles. We showed that realistic human oral airway replicas (including the oral cavity, pharynx, and larynx regions) provided useful spherical and fiber particle deposition in the human head airway. These data could be used to test the thoracic fraction curves. The spherical penetration is in agreement with human in vivo data used to establish the thoracic fraction curve. Fiber penetrations through the larynx of two human oral airway replicas were higher than those for spherical particles for the same aerodynamic diameter using the same replicas. The thoracic curve as defined for spherical particles, therefore, may not include some fibers that could penetrate to the thoracic region. PMID:23414241

Cheng, Yung Sung; Su, Wei-Chung

2013-01-01

163

Pomegranate extract attenuates unilateral ureteral obstruction-induced renal damage by reducing oxidative stress  

PubMed Central

Aims: Ureteral obstruction may cause permanent kidney damage at late period. We know that the pomegranate extract (PE) play a strong role on removal of free oxygen radicals and prevention of oxidative stress. In the current study study, we evaluated the effect of PE on kidney damage after unilateral ureteral obstruction (UUO). Settings and Design: A total of 32 rats were divided into four groups. Group 1 was a control, Group 2 was a sham, Group 3 was rats with UUO and Group 4 was rats with UUO that were given PE (oral 100 ?L/day). After 14 days, rats were killed and their kidneys were taken and blood analysis was performed. Subjects and Methods: Tubular necrosis, mononuclear cell infiltration, and interstitial fibrosis scoring were determined histopathologically in a part of kidneys; nitric oxide (NO), malondialdehyde (MDA), and reduced glutathione (GSH) levels were determined in the other part of kidneys. Statistical Analysis Used: Statistical analyses were performed by the Chi-square test and one-way analysis of variance. Results: There was no difference significantly for urea-creatinine levels between groups. Pathologically, there was serious tubular necrosis, mononuclear cell infiltration and fibrosis in Group 3, and there was significantly decreasing for tubular necrosis, mononuclear cell infiltration and fibrosis in Group 4 (P < 0.005). Furthermore, there was significantly increasing for NO and MDA levels; decreasing for GSH levels in Group 3 compared the other groups (P < 0.005). Conclusions: We think that the PE prevents kidney damage by decreasing oxidative stress in kidney.

Otunctemur, Alper; Ozbek, Emin; Cakir, Suleyman Sami; Polat, Emre Can; Dursun, Murat; Cekmen, Mustafa; Somay, Adnan; Ozbay, Nurver

2015-01-01

164

Omi/HtrA2 protease is associated with tubular cell apoptosis and fibrosis induced by unilateral ureteral obstruction.  

PubMed

Kidney fibrosis, a typical characteristic of chronic renal disease, is associated with tubular epithelial cell apoptosis. The results of our recent studies have shown that Omi/HtrA2 (Omi), a proapoptotic mitochondrial serine protease, performs a crucial function in renal tubular epithelial apoptotic cell death in animal models of acute kidney injury, including cisplatin toxicity and ischemia-reperfusion insult. However, the role of Omi in tubulointerstitial disease-associated fibrosis in the kidney remains to be clearly defined. We evaluated the potential function and molecular mechanism of Omi in ureteral obstruction-induced kidney epithelial cell apoptosis and fibrosis. The mice were subjected to unilateral ureteral obstruction (UUO) via the ligation of the left ureter near the renal pelvis. UUO increased the protein level of Omi in the cytosolic fraction of the kidney, with a concomitant reduction in the mitochondrial fraction. UUO reduced the X-linked inhibitor of apoptosis protein (XIAP), a substrate of Omi, and pro-caspase-3, whereas it increased cleaved poly(ADP-ribose) polymerase (cleaved PARP) and the number of terminal deoxynucleotidyl transferase dUTP nick-end labeling (TUNEL)-positive cells. When mice were treated with ucf-101, an inhibitor of the proteolytic activity of Omi (6.19 microg/day ip), on a daily basis beginning 2 days before UUO and continuing until the end of the experiment, the Omi inhibitor protected XIAP cleavage after UUO and reduced the increment of PARP cleavage and the numbers of TUNEL-positive cells. Furthermore, the Omi inhibitor significantly attenuated UUO-induced increases in fibrotic characteristics in the kidney, including the atrophy and dilation of tubules, expansion of the interstitium, and increases in the expression of collagens, alpha-smooth muscle actin, and fibronectin. In conclusion, Omi/HtrA2 is associated with apoptotic signaling pathways in tubular epithelial cells activated by unilateral ureteral obstruction, thereby resulting in kidney fibrosis. PMID:20219823

Kim, Jinu; Kim, Dong Sun; Park, Mae Ja; Cho, Hee-Jung; Zervos, Antonis S; Bonventre, Joseph V; Park, Kwon Moo

2010-06-01

165

Omi/HtrA2 protease is associated with tubular cell apoptosis and fibrosis induced by unilateral ureteral obstruction  

PubMed Central

Kidney fibrosis, a typical characteristic of chronic renal disease, is associated with tubular epithelial cell apoptosis. The results of our recent studies have shown that Omi/HtrA2 (Omi), a proapoptotic mitochondrial serine protease, performs a crucial function in renal tubular epithelial apoptotic cell death in animal models of acute kidney injury, including cisplatin toxicity and ischemia-reperfusion insult. However, the role of Omi in tubulointerstitial disease-associated fibrosis in the kidney remains to be clearly defined. We evaluated the potential function and molecular mechanism of Omi in ureteral obstruction-induced kidney epithelial cell apoptosis and fibrosis. The mice were subjected to unilateral ureteral obstruction (UUO) via the ligation of the left ureter near the renal pelvis. UUO increased the protein level of Omi in the cytosolic fraction of the kidney, with a concomitant reduction in the mitochondrial fraction. UUO reduced the X-linked inhibitor of apoptosis protein (XIAP), a substrate of Omi, and pro-caspase-3, whereas it increased cleaved poly(ADP-ribose) polymerase (cleaved PARP) and the number of terminal deoxynucleotidyl transferase dUTP nick-end labeling (TUNEL)-positive cells. When mice were treated with ucf-101, an inhibitor of the proteolytic activity of Omi (6.19 ?g/day ip), on a daily basis beginning 2 days before UUO and continuing until the end of the experiment, the Omi inhibitor protected XIAP cleavage after UUO and reduced the increment of PARP cleavage and the numbers of TUNEL-positive cells. Furthermore, the Omi inhibitor significantly attenuated UUO-induced increases in fibrotic characteristics in the kidney, including the atrophy and dilation of tubules, expansion of the interstitium, and increases in the expression of collagens, ?-smooth muscle actin, and fibronectin. In conclusion, Omi/HtrA2 is associated with apoptotic signaling pathways in tubular epithelial cells activated by unilateral ureteral obstruction, thereby resulting in kidney fibrosis. PMID:20219823

Kim, Jinu; Kim, Dong Sun; Park, Mae Ja; Cho, Hee-Jung; Zervos, Antonis S.; Bonventre, Joseph V.

2010-01-01

166

Twist Relates to Tubular Epithelial-Mesenchymal Transition and Interstitial Fibrogenesis in the Obstructed Kidney  

Microsoft Academic Search

Epithelial-mesenchymal transition (EMT) is a critical step in renal fibrosis. It has been recently reported that a transcription factor, Twist, plays a pivotal role in metastasis of breast tumors by inducing EMT. In this study, we examined whether Twist relates to renal fibrogenesis including EMT of tubular epithelia, evaluating Twist expression level in the unilateral ureteral obstruction (UUO) model. Kidneys

Yujiro Kida; Kinji Asahina; Hirobumi Teraoka; Inna Gitelman; Tetsuji Sato

2007-01-01

167

Right lump kidney with varied vasculature and urinary system revealed by multidetector computed tomographic (MDCT) angiography.  

PubMed

Renal ectopia also known as ectopic kidney is an embryological renal anomaly characterised by abnormal anatomical location of one or both of the kidneys. This can occur in various forms such as (1) crossed fused renal ectopia, (2) ectopic thoracic kidney and (3) pelvic kidneys. The lump kidney is one of the six variations of crossed fused ectopic kidney. Throughout life, the patient may remain asymptomatic, however, symptomatic patients may present with minor traumatic injuries due to the abnormal location or normal kidney pathologies. During normal embryological development, there is cephalic migration during which the kidneys ascend to their normal retroperitoneal location; therefore, an ectopic location is as a result of arrested migration. During this embryological development the kidney has multiple aorto-illiac branches, which degenerate when the kidney reaches its normal location. Here they develop new renal branches from the aorta and during an arrested ascent the ectopic kidney tends to retain some of the older aorto-iliac vessels. Hence, the arterial supply and the veineux drainage are grossly abnormal, reflecting the metanephric malascent and the primitive vascular arrangement. The collecting systems also present with important anatomical variations. We present an extremely rare case of right lump kidney with six renal arteries, two renal veins and two duplicated pelvicalyceal systems. PMID:25380828

Miclaus, Gratian D; Pupca, Gheorghe; Gabriel, Abigail; Matusz, Petru; Loukas, Marios

2014-11-01

168

Unilateral pedicle screws asymmetric tethering: an innovative method to create idiopathic deformity  

PubMed Central

Objective To evaluate the feasibility of the method that unilateral pedicle screws asymmetric tethering in concave side in combination with convex rib resection for creating idiopathic deformity. Summary of background data Various methods are performed to create idiopathic deformity. Among these methods, posterior asmmetric tethering of the spine shows satisfying result, but some drawbacks related to the current posterior asymmetric tether were still evident. Materials and methods Unilateral pedicle screws asymmetric tethering was performed to 14 female goats (age: 5–8 week-old, weight: 6–8 kg) in concave side in combination with convex rib resection. Dorsoventral and lateral plain radiographs were taken of each thoracic spine in the frontal and sagittal planes right after the surgery and later every 4 weeks. Results All animals ambulated freely after surgery. For technical reasons, 2 goats were excluded (one animal died for anesthetic during the surgery, and one animal was lost for instrumental fail due to postoperative infection). Radiography showed that 11 goats exhibited scoliosis with convex toward to the right side, and as the curve increased with time, only 1 goat showed nonprogressive. The initial scoliosis generated in the progressors after the procedures measured 29.0° on average (range 23.0°–38.5°) and increased to 43.0° on average (range 36.0°–58.0°) over 8 to 10 weeks. The average progression of 14.0° was measured. The curvature immediately after tethering surgery (the initial Cobb angle) did have a highly significant correlation with the final curvature (p < 0.001). The progressive goats showed an idiopathic-like deformity not only by radiography, but in general appearance. Conclusion Unilateral pedicle screws asymmetric tethering is a practical method to create experimental scoliosis, especially for those who would like to study the correction of this deformity. PMID:17974008

Zhang, Yonggang; Wang, Yan; Zheng, Guoquan; Zhang, Xuesong; Zhang, Ruyi; Zhang, Wei

2007-01-01

169

Thoracic Duct Embolization for Chylous Leaks  

PubMed Central

Chylous leaks, such as chylothorax and chylopericardium, are uncommon effusions resulting from the leakage of intestinal lymphatic fluid from the thoracic duct (TD) and its tributaries, or intestinal lymphatic ducts. The cause can be either traumatic (thoracic surgery) or nontraumatic (idiopathic, malignancy). Treatment has traditionally consisted of dietary modification (nonfat diet) and/or surgery (TD ligation, pleurodesis). Thoracic duct embolization (TDE) has become a viable treatment alternative due to it high success rate and minimal complications. In this article, the authors describe the etiologies of chylothorax, patient population, outcomes, and long-term follow-up of TDE patients. Relevant lymphatic anatomy and physiology are reviewed, with special attention paid to the formation of the duct by tributaries at the cisterna chyli (CC). The technique of TDE is outlined, including bilateral pedal lymphangiography, TD cannulation, and embolic agents used for the procedure. PMID:22379277

Chen, Eric; Itkin, Maxim

2011-01-01

170

European institutional accreditation of general thoracic surgery.  

PubMed

To improve standardization of general thoracic surgery (GTS) practice across Europe, the European Society of Thoracic Surgeons (ESTS) has implemented a program of Institutional Accreditation. We reviewed the methods and rules of engagement of this program. A composite performance score (CPS) including outcome and process indicators is used to measure institutional performance and assess eligibility for accreditation. Eligible units are invited to participate and accept a local audit performed by an external auditors team composed by data inspectors and thoracic surgeons. In addition to data quality, a series of structural, procedural and qualification characteristics are inspected. Once the visit is complete, the team will produce an audit report to be sent to the members of the database committee for deliberation on the institutional accreditation of that unit. The Database committee will send an executive report to the ESTS Executive Committee for their final decision on the accreditation. PMID:24868447

Brunelli, Alessandro; Falcoz, Pierre Emmanuel

2014-05-01

171

European institutional accreditation of general thoracic surgery  

PubMed Central

To improve standardization of general thoracic surgery (GTS) practice across Europe, the European Society of Thoracic Surgeons (ESTS) has implemented a program of Institutional Accreditation. We reviewed the methods and rules of engagement of this program. A composite performance score (CPS) including outcome and process indicators is used to measure institutional performance and assess eligibility for accreditation. Eligible units are invited to participate and accept a local audit performed by an external auditors team composed by data inspectors and thoracic surgeons. In addition to data quality, a series of structural, procedural and qualification characteristics are inspected. Once the visit is complete, the team will produce an audit report to be sent to the members of the database committee for deliberation on the institutional accreditation of that unit. The Database committee will send an executive report to the ESTS Executive Committee for their final decision on the accreditation. PMID:24868447

Falcoz, Pierre Emmanuel

2014-01-01

172

Genetics Home Reference: Familial thoracic aortic aneurysm and dissection  

MedlinePLUS

... literature OMIM Genetic disorder catalog Conditions > Familial thoracic aortic aneurysm and dissection (often shortened to familial TAAD ) On ... January 2015 What is familial TAAD? Familial thoracic aortic aneurysm and dissection (familial TAAD) involves problems with the ...

173

Akt2 Is Involved in Loss of Epithelial Cells and Renal Fibrosis following Unilateral Ureteral Obstruction  

PubMed Central

Obstructive nephropathy is an aggressive form of chronic kidney disease (CKD), which is characterized by an epithelial-to-mesenchymal transition (EMT) and interstitial fibrosis. However, the molecular mechanisms of EMT and fibrosis are complex and not fully understood. In this study, we investigated the contribution of Akt2 to experimental renal EMT and fibrosis using the well-established model of unilateral ureteral obstruction (UUO). We found that Akt2 and phosphor (p)-Akt protein levels were increased in the obstructed kidneys. UUO induced activation of transforming growth factor-?1 (TGF-?1) signaling. Importantly, knockout of Akt2 suppressed UUO-induced EMT, kidney fibrosis, increased GSK3? activity, and decreased expression of Snail and ?-catenin. Inhibition of GSK3? with LiCl (the inhibitor of GSK3?) increased the expression of Snail and ?-catenin in cultured kidney epithelial cells. Our findings suggest that Akt2 partially contributes to interstitial fibrosis following UUO and that inhibition of this signaling pathway may provide a novel approach of prevent progression of renal fibrosis. PMID:25148525

Lan, Aiping; Zhang, Jing; Xiao, Zhicheng; Peng, Xiaogang; Qi, Yongfen; Du, Jie

2014-01-01

174

[Nursing care of unilateral neglect patients].  

PubMed

The prevalence of unilateral neglect among stroke patients has risen to 82% and 69%, respectively, in acute wards and rehabilitation units. Neglect may restrict the activities of patients and reduce their quality of life. Patients are often unaware of their neglect behavior and of their inability to see or feel persons or objects on their affected side. Healthcare providers should pay greater attention to the signs of neglect behavior in patients. Neglect is a silent syndrome for both patients and healthcare providers. This article reviews the definition of unilateral neglect as well as its associated characteristics, theoretical interpretations, rehabilitation, and nursing care. The authors hope that the contents of this article may help healthcare professionals assess and provide care to patients with neglect problems in order to decrease the negative impacts of neglect on patients and improve their daily functions. PMID:25631189

Dai, Chin-Ying; Lin, Li-Chan

2015-02-01

175

Unilateral Punctate Keratitis Secondary to Wallenberg Syndrome  

PubMed Central

We studied three patients who developed left unilateral punctate keratitis after suffering left-sided Wallenberg Syndrome. A complex evolution occurred in two of them. In all cases, neurophysiological studies showed damage in the trigeminal sensory component at the bulbar level. Corneal involvement secondary to Wallenberg syndrome is a rare cause of unilateral superficial punctate keratitis. The loss of corneal sensitivity caused by trigeminal neuropathy leads to epithelial erosions that are frequently unobserved by the patient, resulting in a high risk of corneal-ulcer development with the possibility of superinfection. Neurophysiological studies can help to locate the anatomical level of damage at the ophthalmic branch of the trigeminal nerve, confirming the suspected etiology of stroke, and demonstrating that prior vascular involvement coincides with the location of trigeminal nerve damage. In some of these patients, oculofacial pain is a distinctive feature. PMID:24882965

Boto, Ana; Del Hierro, Almudena; Capote, Maria; Noval, Susana; Garcia, Amanda; Santiago, Susana

2014-01-01

176

Unilateral lung hyperlucency after mediastinal irradiation  

SciTech Connect

A 39-yr-old woman developed progressive exertional dyspnea 13 yr after receiving mediastinal irradiation for Hodgkin's disease. Chest roentgenogram showed a hyperlucent right lung. Pulmonary blood flow was markedly reduced on the right by ventilation-perfusion scanning. Pulmonary angiography showed attenuation and diffuse atrophy of the right pulmonary artery and its branches. This case represents a late and uncommon complication of mediastinal irradiation manifesting as a unilateral hyperlucent lung.

Wencel, M.L.; Sitrin, R.G.

1988-04-01

177

Unilateral musical hallucinations and all that jazz.  

PubMed

A 78-year-old hearing-impaired woman who presented to hospital with a stroke and a subsequent epileptic seizure later developed unilateral musical hallucinations in her better hearing (right) ear. She was found to have a left-sided temporal epileptic focus and the music ceased after a second anti-convulsant was introduced. Comments are made on unusual features of the hallucination and its probable causation. PMID:7893249

Couper, J

1994-09-01

178

Liver-Type Fatty Acid-Binding Protein Attenuates Renal Injury Induced by Unilateral Ureteral Obstruction  

PubMed Central

Liver-type fatty-acid-binding protein (L-FABP), which has high affinity for long-chain fatty acid oxidation products, may be an effective endogenous antioxidant. To examine the role of L-FABP in tubulointerstitial damage, we used a unilateral ureteral obstruction (UUO) model. We established human L-FABP (hL-FABP) gene transgenic (Tg) mice and compared the tubulointerstitial pathology of the Tg mice (n = 23) with that of the wild-type (WT) mice (n = 23). Mice were sacrificed on days 2, 4, 5, or 7 after UUO. Although mouse L-FABP was not expressed in WT mice, hL-FABP was expressed in the proximal tubules of the Tg mice with UUO (UUO-Tg) and in sham-operated Tg mice. The expression of renal hL-FABP was significantly increased in UUO-Tg compared with sham-operated Tg mice. The number of macrophages (F4/80) infiltrating the interstitium and the level of expression of MCP-1 and MCP-3 were significantly lower in UUO-Tg kidneys compared with UUO-WT kidneys. In UUO-Tg kidneys, the degree of the tubulointerstitial injury and the deposition of type I collagen were significantly lower than that of UUO-WT kidneys. On day 7, lipid peroxidation product accumulated in the UUO-WT kidneys but not in that of UUO-Tg kidneys. In conclusion, renal L-FABP may reduce the oxidative stress in the UUO model, ameliorating tubulointerstitial damage. PMID:17003471

Kamijo-Ikemori, Atsuko; Sugaya, Takeshi; Obama, Ayako; Hiroi, Junya; Miura, Hiroshi; Watanabe, Minoru; Kumai, Toshio; Ohtani-Kaneko, Ritsuko; Hirata, Kazuaki; Kimura, Kenjiro

2006-01-01

179

Coexisting Papillary and Clear Renal Cell Carcinoma in the Same Kidney  

PubMed Central

Renal cell carcinoma (RCC) is the most common solid lesion of the kidney. Bilateral synchronous benign and malignant renal tumors have been defined in some reports. However, unilateral concordance of malignant renal tumors is very rare and there are only a few cases that had synchronous different subtypes of malignant renal tumors arising within the same kidney. Herein, we describe a 67-year-old male patient who had clear cell RCC and papillary RCC in his right kidney that were successfully treated with radical nephrectomy. We also reviewed the pertinent literature. PMID:25180117

Yaprak, Busra; Teke, Kerem; Ciftci, Seyfettin; Yildiz, Kursat; Culha, Melih

2014-01-01

180

Use of the BioMedicus centrifugal pump in traumatic tears of the thoracic aorta.  

PubMed

Traumatic blunt thoracic aortic injury is a clinical entity of increasing incidence. After the diagnosis of traumatic tear of the aorta is made, there is some controversy over whether the aorta should be repaired using cardiopulmonary bypass, a heparinized shunt, or cross-clamping and graft interposition without a shunt or bypass. At Allegheny General Hospital, 19 patients were treated for traumatic tears of the thoracic aorta between July 1, 1977, and June 30, 1983. They can be divided into two groups: Group 1 (July 1, 1977, through October 31, 1981), in which no shunt or bypass or only a heparinized shunt was used, and Group 2 (November 1, 1981, through June 30, 1983), in which left atrium-femoral artery bypass was performed using a BioMedicus heparinless pump and tubing. Among the 10 patients in Group 1, 4 died and 2 had paraplegia postoperatively. Among the 9 patients in Group 2, 1 died and none experienced paraplegia following operation. We believe that the BioMedicus centrifugal pump is a simple, safe means of perfusing the lower body, kidneys, and spinal column without necessitating heparinization in a patient with multiple injuries or the placement of a cumbersome heparinized shunt. Because of the simplicity and the reliability demonstrated, this pump should be considered for use in all patients with traumatic tears of the thoracic aorta. PMID:6508414

Olivier, H F; Maher, T D; Liebler, G A; Park, S B; Burkholder, J A; Magovern, G J

1984-12-01

181

Evaluation of hypertension by ambulatory blood pressure monitoring in children with solitary kidney.  

PubMed

Abstract In this study, we aimed to investigate the blood pressure (BP) profile in children with a unilateral functioning solitary kidney (UFSK). A group of 49 patients between the ages of 5 and 18 years, and 30 healthy controls between the ages of 6 and 16 years were investigated. Gender, weight, height and body mass index (BMI) of patients and controls were recorded. BP profile was determined by ambulatory BP monitoring (ABPM). We have observed a higher risk of hypertension compared with healthy children. Also, masked hypertension is more frequently in the patients group and white-coat hypertension was observed in the control group. The mean night-time systolic BP (SBP) load (p = 0.01) and 24-h diastolic BP (DBP) load (p = 0.008) of children with multicystic dysplastic kidney (MCDK) was significantly higher than the healthy group. The mean night-time SBP load (p = 0.001) of children with unilateral renal agenesis (URA) and 24-h DBP load (p = 0.003) of children with unilateral atrophic or hypoplastic kidney were significantly higher than healthy group. We showed that the children with a solitary kidney had increased risk of hypertension. ABPM reflects the BP profile more precisely than casual BP measurement and it can be used to evaluate white-coat and masked hypertension in children with a solitary kidney. PMID:25580841

Tabel, Yilmaz; Aksoy, Özlem; Elmas, Ahmet Taner; Çelik, Serkan Fazli

2015-04-01

182

Enhancement of bilateral cortical somatosensory evoked potentials to intact forelimb stimulation following thoracic contusion spinal cord injury in rats.  

PubMed

The adult central nervous system is capable of significant reorganization and adaptation following neurotrauma. After a thoracic contusive spinal cord injury (SCI) neuropathways that innervate the cord below the epicenter of injury are damaged, with minimal prospects for functional recovery. In contrast, pathways above the site of injury remain intact and may undergo adaptive changes in response to injury. We used cortical somatosensory evoked potentials (SSEPs) to evaluate changes in intact forelimb pathways. Rats received a midline contusion SCI, unilateral contusion SCI, or laminectomy with no contusion at the T8 level and were monitored for 28 days post-injury. In the midline injury group, SSEPs recorded from the contralateral forelimb region of the primary somatosensory cortex were 59.7% (CI 34.7%, 84.8%; c(2) = 21.9; dof = 1; p = 2.9 ×10(-6)) greater than the laminectomy group; SSEPs from the ipsilateral somatosensory cortex were 47.6% (CI 18.3%, 77%; c(2) = 10.1; dof = 1; p = 0.001) greater. Activation of the ipsilateral somatosensory cortex was further supported by BOLD-fMRI, which showed increased oxygenation at the ipsilateral hemisphere at day seven post-injury. In the unilateral injury group, ipsilesional side was compared to the contralesional side. SSEPs on day 14 (148%; CI 111%, 185%) and day 21 (137%; CI 110%, 163%) for ipsilesional forelimb stimulation were significantly increased over baseline (100%). SSEPs recorded from the hindlimb sensory cortex upon ipsilesional stimulation were 33.9% (CI 14.3%, 53.4%; c(2) = 11.6; dof = 1; p = 0.0007) greater than contralesional stimulation. Therefore, these results demonstrate the ability of SSEPs to detect significant enhancements in the activation of forelimb sensory pathways following both midline and unilateral contusive SCI at T8. Reorganization of forelimb pathways may occur after thoracic SCI, which SSEPs can monitor to aid the development of future therapies. PMID:24801738

Bazley, Faith A; Maybhate, Anil; Tan, Chuen Seng; Thakor, Nitish V; Kerr, Candace; All, Angelo H

2014-09-01

183

Osteochondroma Arising from the Thoracic Transverse Process  

PubMed Central

The incidence of osteochondroma is rare and only 2% of such tumors are found in the spine area. When they are found in the vertebral column, less than 1% of all osteochondromas and few tumors occur in the thoracic vertebrae. An osteochondroma arising from the transverse process of the vertebra is even rarer, especially following from the thoracic transverse process. Here we report a giant solitary osteochondroma arising from the thoracic transverse process of T8 vertebra and involving the corresponding transverse process and rib. A 28-year-old man presented with a progressive thoracic node, and neuroradiological evaluation of the spine showed a giant mass lesion involving the transverse process of T8 vertebra and concomitant corresponding facet joint and rib on the left side. At surgery, a firm and cartilaginous tumor originating from the transverse process was radically excised and surgical curettage of the lesion was performed. It is concluded that accurate and prompt diagnosis requires a high index of suspicion followed by surgical treatment to prevent severe morbidity in cases of primary spinal column tumors. The histological examination of this patient revealed the lesion was osteochondroma. The best choice of treatment for spinal osteochondromas is surgical excision or curettage and spinal stabilization, if necessary.

Wenyuan, Ding; Baojun, Li; Yong, Shen; Wei, Zhang

2009-01-01

184

Post-Traumatic Thoracic Outlet Syndromes  

Microsoft Academic Search

This retrospective study aims to clarify the mechanisms, frequency, symptoms, treatment, and outcome of post-traumatic thoracic outlet syndromes. A total of 13 patients (7 men and 6 women) with a mean age of 41±16 years were studied. Underlying injuries resulted from sports, road, and household accidents. Bone lesions were pseudarthrosis, hypertrophic callus, and luxations. Congenital anomalies were observed in five

Laurent Casbas; Xavier Chauffour; Jérôme Cau; Jean-Pierre Bossavy; Dominique Midy; Jean-Claude Baste; André Barret

2005-01-01

185

Ependymal cyst of the thoracic spinal cord  

PubMed Central

A unique case of an ependymal cyst on the anterior aspect of the thoracic spinal cord in a woman aged 68 years is described. Clinical signs were precipitated by trauma. Recovery of function, while incomplete, was remarkably good after extirpation of the cyst. Images PMID:4419009

Gainer, J. V.; Chou, S. M.; Nugent, G. R.; Weiss, V.

1974-01-01

186

Functional chiral asymmetry in descending thoracic aorta.  

PubMed

To determine whether rotational blood flow or chiral asymmetry exists in the human descending thoracic aorta, we established the ability of color Doppler ultrasound to detect rotational flow in a tornado tube model of a vortex descending fluid column. In a model of the human aortic arch with a pulse duplicator, color Doppler was then used to demonstrate that rotational flow occurs first in the transverse arch and then in the proximal descending thoracic aorta. With the use of color Doppler esophageal echocardiography, 53 patients (age range, 25-78 years; mean age, 56.4 years) were prospectively examined for rotational flow in the descending thoracic aorta. At 10 cm superior to retro-left ventricular position, 22 of 38 patients (58%) revealed rotational flow with obvious diastolic counterclockwise rotation but less obvious systolic clockwise rotation. At 5 cm superior to retro-left ventricular position, 29 of 46 patients (63%) revealed rotational flow with a tendency toward systolic clockwise and diastolic counterclockwise rotation. At the retro-left ventricular position, 47 of 53 patients (89%) revealed rotational flow, usually of a clockwise direction, occurring in systole. Our data suggest that aortic flow is not purely pulsatile and axial but has a rotational component. Rotational flow begins in the aortic arch and is carried through to the descending thoracic aorta, where flow is chirally asymmetric with systolic clockwise and diastolic counterclockwise components. These data demonstrate an aortic rotational flow component that may have physiological implications for organ perfusion. PMID:2242523

Frazin, L J; Lanza, G; Vonesh, M; Khasho, F; Spitzzeri, C; McGee, S; Mehlman, D; Chandran, K B; Talano, J; McPherson, D

1990-12-01

187

Thoracic Surgery and Asymptomatic Coronary Artery Disease  

Microsoft Academic Search

\\u000a The diagnostic and therapeutic management of patients with coronary artery disease (CAD), either symptomatic or asymptomatic,\\u000a who are scheduled for thoracic surgery has not yet clearly been defi ned and remains controversial (Carbajal 1998).

Jean-Pierre Laissy

188

Modulation of Intraocular Pressure by Unilateral and Forced Unilateral Nostril Breathing in Young Healthy Human Subjects  

Microsoft Academic Search

Purpose: To determine the effects of unilateral right\\/left nostril breathing (URNB\\/ULNB) and forced unilateral right\\/left nostril\\u000a breathing (FURNB\\/FULNB) on intraocular pressure (IOP) and to examine the differences in the IOP during the various phases\\u000a of nasal cycle. Methods: Young healthy volunteers of either sex aged between 19-24 years, participated in the sessions using URNB\\/ULNB (n = 52) and\\u000a FURNB\\/FULNB (n

Satagopam Mitti Mohan; Sagili Chandrasekhara Reddy; Lee Yoong Wei

2001-01-01

189

An electrophysiological follow-up study on acquired unilateral nyctalopia  

Microsoft Academic Search

Purpose To describe the clinical picture and electrophysiological findings in acquired unilateral nyctalopia.Methods A patient who had acquired unilateral visual loss with normal fundus was followed for a period of 2.5 years with basic ophthalmological examinations including standard electroretinogram and photopic on and off responses.Results A 46-year-old woman suffered from acquired unilateral nyctalopia. She complained of photopsia and blurred vision

Koichiro Murayama; Hidehiko Kawabata; Emiko Adachi-Usami

1999-01-01

190

Bite force in pre-orthodontic children with unilateral crossbite  

Microsoft Academic Search

SUMMARY In the present study bite force was examined in pre-orthodontic children with unilateral posterior crossbite and compared with an age- and sex-matched control group. The sample comprised 52 children aged 7-13 years, 26 pre-orthodontic children with unilateral posterior crossbite (crossbite group), and 26 children with neutral occlusion (control group). Unilateral bite force was measured at the first molar by

Liselotte Sonnesen; Merete Bakke; Beni Solow

2001-01-01

191

Transcatheter Arterial Embolization Therapy for a Hypoplastic Pelvic Kidney with a Single Vaginal Ectopic Ureter to Control Incontinence: The Usefulness of Three-Dimensional CT Angiography Using Multidetector-Row Helical CT  

SciTech Connect

A girl with continuous urinary incontinence was successfully treated by angiographic embolization of a hypoplastic pelvic kidney with a single unilateral vaginal ectopic opening of the ureter. For this intervention, CT angiography was useful for detecting the corresponding renal artery of the hypoplastic kidney.

Kudoh, Kouichi, E-mail: cdk70770@par.odn.ne.jp; Kadota, Masataka; Nakayama, Yoshiharu; Imuta, Masanori; Yasuda, Tsuyoshi; Yamashita, Yasuyuki [Kumamoto University School of Medicine, Kumamoto, Department of Radiology (Japan); Inadome, Akito; Yoshida, Masaki; Ueda, Shouichi [Kumamoto University School of Medicine, Kumamoto, Department of Urology (Japan)

2003-09-15

192

Kidney Dysplasia National Kidney and Urologic Diseases Information Clearinghouse  

E-print Network

Kidney Dysplasia National Kidney and Urologic Diseases Information Clearinghouse U.S. Department of Health and Human Services NATIONAL INSTITUTES OF HEALTH What is kidney dysplasia? The kidneys are a pair the kidneys to the bladder through tubes called ureters. Kidney dysplasia is a condition that can occur

Baker, Chris I.

193

Kidney Disease: A Silent Problem  

MedlinePLUS

... hormones that your body needs to stay healthy. Kidney Disease Kidney disease can sometimes develop very quickly, ... disease, arthritis , and nerve damage. Medicine And Your Kidneys Older people often take lots of medicines. Kidneys ...

194

Diabetes and Chronic Kidney Disease  

MedlinePLUS

... Rate Your Risk Quiz Featured Story African Americans & Kidney Disease Did you know that African Americans are ... KEEP Healthy - Free Kidney Health checks Featured Story Kidney Walk The Kidney Walk is the nation's largest ...

195

Sexuality and Chronic Kidney Disease  

MedlinePLUS

... Rate Your Risk Quiz Featured Story African Americans & Kidney Disease Did you know that African Americans are ... KEEP Healthy - Free Kidney Health checks Featured Story Kidney Walk The Kidney Walk is the nation's largest ...

196

Kidney Failure: What to Expect  

MedlinePLUS

... Topics and Titles : Kidney Failure: What to Expect Kidney Failure: What to Expect On this page: How ... through Research For More Information Acknowledgments How does kidney failure affect a person’s health? Kidney failure can ...

197

Flu Season and Your Kidneys  

MedlinePLUS

... Rate Your Risk Quiz Featured Story African Americans & Kidney Disease Did you know that African Americans are ... KEEP Healthy - Free Kidney Health checks Featured Story Kidney Walk The Kidney Walk is the nation's largest ...

198

Kidney Histology Rules Matrix  

Cancer.gov

Kidney Histo Kidney Histology Coding Rules – Matrix C649 (Excludes lymphoma and leukemia M9590 – 9989 and Kaposi sarcoma M9140) Rule Pathology/Cytology Specimen Histology Behavior Notes and Examples Code SINGLE TUMOR H1 None or the pathology

199

American Kidney Fund  

MedlinePLUS

... News American Kidney Fund Denounces CMS’ New ‘Five Star Rating System’ for Dialysis Facilities American Kidney Fund ... Work Consumers Digest Top Charity Consumers Digest 4-Star Charity (13th consecutive year) Charity Navigator Stay Connected ...

200

Kidney and Urologic Diseases  

MedlinePLUS

... and CKD (for health care professionals) Blood Urea Nitrogen (BUN) (from MedlinePlus) Bone Disease of Kidney Failure ... Enlargement: Benign Prostatic Hyperplasia ) BUN (See Blood Urea Nitrogen ) C Calcitriol (See Chronic Kidney Disease-Mineral and ...

201

Acute arterial occlusion - kidney  

MedlinePLUS

Acute renal arterial thrombosis; Renal artery embolism; Acute renal artery occlusion; Embolism - renal artery ... kidneys need a good blood supply. The main artery to the kidney is called the renal artery. ...

202

Kidney Disease of Diabetes  

MedlinePLUS

... ACE) inhibitors and angiotensin receptor blockers (ARBs), have proven effective in slowing the progression of kidney disease. ... ACE) inhibitors and angiotensin receptor blockers (ARBs), have proven effective in slowing the progression of kidney disease. ...

203

Kidney transplant - series (image)  

MedlinePLUS

... failure caused by: severe, uncontrollable high blood pressure (hypertension) infections diabetes mellitus congenital abnormalities of the kidneys other diseases which cause renal failure, such as autoimmune disease Donor kidneys are obtained ...

204

Polycystic Kidney Disease (PKD)  

MedlinePLUS

... 60% of people who have PKD also have high blood pressure, which can be treated with medicine. About 50% of patients who have PKD have kidney failure by age 60. Dialysis (blood filtering) and kidney ...

205

The European educational platform on thoracic surgery  

PubMed Central

As the largest scientific organisation world-wide exclusively dedicated to general thoracic surgery (GTS), the European Society of Thoracic Surgeons (ESTS) recognized that one of its priorities is education. The educational platform designed ESTS addresses not only trainees, but also confirmed thoracic surgeons. The two main aims are (I) to prepare trainees to graduation and to the certification by the European Board of Thoracic Surgery and (II) to offer opportunities for continuous medical education in the perspective of life-long learning and continuous professional development to certified thoracic surgeons. It is likely that recertification will become an obligation during the coming decade. At its inception, the platform differentiated two different events. A 6-day course emphasizing on theoretic knowledge was created in Antalya in 2007. The same year, a 2-day school oriented to practical issues with hands-on in the animal lab was launched in Antalya. These two teaching tracks need further development. In the knowledge track, we intend to organize highly specialized 2-day courses to deepen insight into theoretical questions. The skill track will be implemented by specialized courses for high technology such as tracheal surgery, ECMO, robotics or chest wall reconstruction. In order to promote tomorrows’ leadership, we created an academic competence track giving an insight into medical communication, methodology and management. We also had to respond to an increasing demand from the Russian speaking countries, where colleagues may face problems to attend western meetings, and where the language bareer may be a major impediment. We initiated a Russian school with three events yearly in 2012. Contemporary teaching must be completed with an e-learning platform, which is currently under development. The school activities are organized by the educational committee, which is headed by the ESTS Director of Education, assisted by coordinators of the teaching tracks and e-learning platform. Ongoing discussions concern development of contemporary teaching techniques and measure of outcome. The major challenge for the coming years is harmonisation of training and certification in thoracic surgery in the European space. PMID:24868446

Rocco, Gaetano; Venuta, Federico

2014-01-01

206

The European educational platform on thoracic surgery.  

PubMed

As the largest scientific organisation world-wide exclusively dedicated to general thoracic surgery (GTS), the European Society of Thoracic Surgeons (ESTS) recognized that one of its priorities is education. The educational platform designed ESTS addresses not only trainees, but also confirmed thoracic surgeons. The two main aims are (I) to prepare trainees to graduation and to the certification by the European Board of Thoracic Surgery and (II) to offer opportunities for continuous medical education in the perspective of life-long learning and continuous professional development to certified thoracic surgeons. It is likely that recertification will become an obligation during the coming decade. At its inception, the platform differentiated two different events. A 6-day course emphasizing on theoretic knowledge was created in Antalya in 2007. The same year, a 2-day school oriented to practical issues with hands-on in the animal lab was launched in Antalya. These two teaching tracks need further development. In the knowledge track, we intend to organize highly specialized 2-day courses to deepen insight into theoretical questions. The skill track will be implemented by specialized courses for high technology such as tracheal surgery, ECMO, robotics or chest wall reconstruction. In order to promote tomorrows' leadership, we created an academic competence track giving an insight into medical communication, methodology and management. We also had to respond to an increasing demand from the Russian speaking countries, where colleagues may face problems to attend western meetings, and where the language bareer may be a major impediment. We initiated a Russian school with three events yearly in 2012. Contemporary teaching must be completed with an e-learning platform, which is currently under development. The school activities are organized by the educational committee, which is headed by the ESTS Director of Education, assisted by coordinators of the teaching tracks and e-learning platform. Ongoing discussions concern development of contemporary teaching techniques and measure of outcome. The major challenge for the coming years is harmonisation of training and certification in thoracic surgery in the European space. PMID:24868446

Massard, Gilbert; Rocco, Gaetano; Venuta, Federico

2014-05-01

207

Effects of unilateral decompressive craniectomy on patients with unilateral acute post-traumatic brain swelling after severe traumatic brain injury  

Microsoft Academic Search

INTRODUCTION: Acute post-traumatic brain swelling (BS) is one of the pathological forms that need emergent treatment following traumatic brain injury. There is controversy about the effects of craniotomy on acute post-traumatic BS. The aim of the present clinical study was to assess the efficacy of unilateral decompressive craniectomy (DC) or unilateral routine temporoparietal craniectomy on patients with unilateral acute post-traumatic

Wusi Qiu; Chenchen Guo; Hong Shen; Keyong Chen; Liang Wen; Hongjie Huang; Min Ding; Li Sun; Qizhou Jiang; Weiming Wang

2009-01-01

208

Long-Term EGF Treatment Partially Prevents Reduction of Renal Blood Flow in Response to Neonatally Induced Partial Unilateral Ureteral Obstruction  

Microsoft Academic Search

Background\\/Aims: To investigate the effects of long-term epidermal growth factor (EGF) treatment on kidney growth, renal blood flow (RBF), AQP2 expression and urine output in newborn rats with partial unilateral ureteral obstruction (PUUO). Methods: PUUO (n = 29) and sham-operated control (CON) (n = 26) was created in 2-day-old rats. Fifteen PUUO and 14 CON rats were treated with EGF

Jian Guo Wen; Gui Xian Wang; Yue Chen; Steffen Ringgaard; Lars Vinter-Jensen; Troels Munch Jørgensen; Zhenzhen Li; Hans Stødkilde-Jørgensen; Søren Nielsen; Jens Christian Djurhuus; Jørgen Frøkiær

2009-01-01

209

Unilateral sudden hearing loss due to otosyphilis  

PubMed Central

The differential diagnosis of sudden hearing loss is very extensive. However, in most patients, no underlying pathology will be found and the patient is consequently diagnosed with idiopathic sudden hearing loss. Nevertheless, it is important that one stays alert in everyday routine practice to less common but potentially treatable pathology. We report a case of a 53-year old patient with sudden unilateral hearing loss and tinnitus caused by otosyphilis. Diagnosis, therapy and the incidence of (oto)syphilis are discussed. Also, as ENT-surgeons, it is important to realise that syphilis is still with us, and that its prevalence might well increase in the near future. PMID:24765374

de Goffau, Maaike J.; Doelman, Jan C.; van Rijswijk, Jeroen B.

2011-01-01

210

[Unilateral hip arthrosis: expression of joint haemochromatosis].  

PubMed

Hereditary haemochromatosis is the most common genetic disorder in the Caucasian population, with an estimated prevalence of 1/200-1/400 (homozygous) and 1/8-1/10 in carriers (heterozygous). The transmission is recessive and linked to HLA. The clinical expression of disease appears only in homozygous and will depend on the time of diagnosis and the degree of organ involvement. The clinical case presented below describes the process of differential diagnosis made in a young patient with unilateral coxarthrosis and clinical suspicion of hemochromatosis. Early diagnosis of hereditary hemochromatosis in primary care can reduce morbidity and mortality of this disease by detecting homozygous at younger ages. PMID:23021581

Prieto Zancudo, C; Villán Villán, Y F; Tascón Guerra, M F

2012-10-01

211

Unilateral athelia with a subcutaneous dermoid cyst.  

PubMed

A case of unilateral athelia with a subcutaneous dermoid cyst in the area in question is reported. The histologic features of the cyst wall suggest that it is derived from a base in the nipple-areola complex. Dozens of cases of congenital absence of the breast have been reported, some of them associated with congenital anhidrotic ectodermal dysplasia, others with additional musculoskeletal abnormalities, and still others normal in other respects. But to our knowledge, the combination of athelia and corresponding subcutaneous dermoid cyst has not been reported. PMID:3671567

Hosokawa, K; Hata, Y; Yano, K; Susuki, T; Kikui, T; Tahara, S

1987-11-01

212

Unilateral Molar Distalization: A Nonextraction Therapy  

PubMed Central

In the recent years, nonextraction treatment approaches and noncompliance therapies have become more popular in the correction of space discrepancies. One of the conventional approaches for space gaining in the arches without patient compliance is done by using certain extra oral appliances or intraoral appliance. The greatest advantage of certain appliances like fixed functional and molar distalization appliances is that they minimize the dependence on patient cooperation. Molar distalization appliances like pendulum appliance which distalizes the molar rapidly without the need of head gear can be used in patients as a unilateral space gaining procedure due to buccal segment crowding. PMID:23320203

Prasad, M. Bhanu; Sreevalli, S.

2012-01-01

213

Adult-Onset Unilateral Disabling Pansclerotic Morphea  

PubMed Central

Disabling pansclerotic morphea (DPM) is a rare, severe, and mutilating form of morphea, involving the dermis, subcutaneous tissue, fat, muscle, and even bone. It is usually seen before the age of 14 years, with the patient complaining of arthralgia and stiffness at the time of onset. We report a case of unilateral adult-onset DPM with sparing of the face. Within a few months of onset, painful contracture deformities of the hand, elbow, and shoulder joints developed, impairing the patient's normal daily activities. We are reporting this case because of the unusual presentation: DPM in an adult, with history of trauma in childhood and rapid onset of complications, is rare. PMID:24891683

Singh, Adarshlata; Singhal, Kritika; Choudhary, Sanjiv; Bisati, Shazia; Arora, Mallika

2014-01-01

214

Unilateral nevoid telangiectasia associated with ipsilateral melorheostosis.  

PubMed

Melorheostosis is a rare disorder characterized by irregular, flowing hyperostosis in long bones, commonly described on radiographs as wax flowing down a candle. In addition to bony sclerosis, cutaneous manifestations overlying the involved bones have been reported including linear scleroderma, neurofibromatosis, and vascular and lymphatic malformations. Unilateral nevoid telangiectasia (UNT) is a rare primarily cutaneous condition characterized by linearly arranged small dilated blood vessels in dermatomal or Blaschkoid patterns on the skin. Here, we present the case of a nine-year-old Korean male with UNT associated with ipsilateral melorheostosis. PMID:22577274

Kim, Jihyun; Cho, Sung Bin; Cho, Suhyun; Bang, Dongsik

2012-05-01

215

Cervical radiculopathy, entrapment neuropathy, and thoracic outlet syndrome: how to differentiate? Invited submission from the Joint Section Meeting on Disorders of the Spine and Peripheral Nerves, March 2004.  

PubMed

The common diagnoses of cervical radiculopathy and upper-extremity entrapment neuropathies can at times be difficult to differentiate. Additionally, thoracic outlet syndrome is often diagnosed when, in fact, the problem is radiculopathy or neuropathy. Another source of confusion, especially in older patients, is neuralgic amyotrophy, brachial plexitis, or the Parsonage-Turner syndrome. The differential diagnosis of unilateral arm pain, weakness, and/or sensory loss includes all of these problems. The clinical and electrodiagnostic features of each are discussed as an aid to distinguishing between these common and similar entities. PMID:15347004

McGillicuddy, John E

2004-09-01

216

Aliskiren restores renal AQP2 expression during unilateral ureteral obstruction by inhibiting the inflammasome.  

PubMed

Ureteral obstruction is associated with reduced expression of renal aquaporins (AQPs), urinary concentrating defects, and an enhanced inflammatory response, in which the renin-angiotensin system (RAS) may play an important role. We evaluated whether RAS blockade by a direct renin inhibitor, aliskiren, would prevent the decreased renal protein expression of AQPs in a unilateral ureteral obstruction (UUO) model and what potential mechanisms may be involved. UUO was performed for 3 days (3UUO) and 7 days (7UUO) in C57BL/6 mice with or without aliskiren injection. In 3UUO and 7UUO mice, aliskiren abolished the reduction of AQP2 protein expression but not AQP1, AQP3, and AQP4. mRNA levels of renal AQP2 and vasopressin type 2 receptor were decreased in obstructed kidneys of 7UUO mice, which were prevented by aliskiren treatment. Aliskiren treatment was also associated with a reduced inflammatory response in obstructed kidneys of UUO mice. Aliskiren significantly decreased mRNA levels of several proinflammatory factors, such as transforming growth factor-? and tumor necrosis factor-?, seen in obstructed kidneys of UUO mice. Interestingly, mRNA and protein levels of the NOD-like receptor family, pyrin domain-containing 3 (NLRP3) inflammasome components apoptosis-associated speck-like protein containing a caspase recruitment domain, caspase-1, and IL-1? were dramatically increased in obstructed kidneys of 7UUO mice, which were significantly suppressed by aliskiren. In primary cultured inner medullary collecting duct cells, IL-1? significantly decreased AQP2 expression. In conclusions, RAS blockade with the direct renin inhibitor aliskiren increased water channel AQP2 expression in obstructed kidneys of UUO mice, at least partially by preventing NLRP3 inflammasome activation in association with ureteral obstruction. PMID:25694485

Wang, Weidong; Luo, Renfei; Lin, Yu; Wang, Feifei; Zheng, Peili; Levi, Moshe; Yang, Tianxin; Li, Chunling

2015-04-15

217

update: acute KIDNEY INJURY  

E-print Network

Guidelines update: acute KIDNEY INJURY August 2012, Issue 8 Tlaleletso is a monthly publication that have acute kidney injury. We review the common presentations and causes, especially in patients living it to cover, please send us your feedback­ either on content or format. Respectfully, Mike Reid Acute kidney

Bushman, Frederic

218

Pairwise kidney exchange  

Microsoft Academic Search

The literature on exchange of indivisible goods finds natural application in the exchange of live donor kidneys for transplant. However, in kidney exchange, there are constraints on the size of exchanges. Initially, kidney exchanges are likely to be between just two patient–donor pairs. We show that, although this constraint eliminates some potential exchanges, there is a wide class of constrained-efficient

Alvin E. Roth; Tayfun Sönmez; M. Utku Ünver

2005-01-01

219

KIDNEY EXCHANGE PROBLEM  

Microsoft Academic Search

To overcome the shortage of kidneys available for transplantation, several countries have started various programmes of kidney exchanges between incompatible patient-donor pairs. This situation can be modelled as a cooperative game in which the players are the patient-donor pairs and their preferences are derived in the first step from the suitability of the donated kidney and in the second step

Peter Biro; Katar ´ ina Cechlarova

220

Endovascular repair of thoracic aortic aneurysm.  

PubMed

A thoracic aortic aneurysm (TAA) is a potentially life-threatening condition with structural weakness of the aortic wall, which can progress to arterial dilatation and rupture. Today, both an increasing awareness of vascular disease and the access to tomographic imaging facilitate the diagnosis of TAA even in an asymptomatic stage. The risk of rupture for untreated aneurysms beyond a diameter of 5.6 cm ranges from 46% to 74% and the two-year mortality rate is greater than 70%, with most deaths resulting from rupture. Treatment options include surgical and non-surgical repair to prevent aneurysm enlargement and rupture. While most cases of ascending aortic involvement are subject to surgical repair (partially with valve-preserving techniques), aneurysm of the distal arch and descending thoracic aorta are amenable to emerging endovascular techniques as an alternative to classic open repair or to a hybrid approach (combining debranching surgery with stent grafting) in an attempt to improve outcomes. PMID:22419919

Akin, Ibrahim; Kische, Stephan; Rehders, Tim C; Nienaber, Christoph A; Rauchhaus, Mathias; Ince, Hüseyin

2010-10-01

221

Video-assisted thoracic surgery and pneumothorax  

PubMed Central

Video-assisted thoracoscopic surgery (VATS) is a type of thoracic surgery performed using a small video camera that is introduced into the patient’s chest via a scope. It is considered a minimally invasive technique where the surgeon is able to view the instruments that are being used along with the anatomy on which the surgeon is operating. The camera and instruments are inserted through separate holes in the chest wall also known as “ports”, depending on the patient and problem there are surgeries with one port “uniport”, two or three ports. These small ports have the advantage that fewer infections are observed. This allows for a faster recovery. Traditionally, thoracic surgery performed for diagnosis or treatment of chest conditions has required access to the chest through thoracotomy or sternotomy incisions. Vats minimally invasive technique has replaced in many cases thoracotomy or sternotomy. In our current review we will present this technique in detail. PMID:25774310

Paliouras, Dimitrios; Barbetakis, Nikolaos; Lazaridis, George; Baka, Sofia; Mpoukovinas, Ioannis; Karavasilis, Vasilis; Kioumis, Ioannis; Pitsiou, Georgia; Papaiwannou, Antonis; Karavergou, Anastasia; Lampaki, Sofia; Katsikogiannis, Nikolaos; Mpakas, Andreas; Tsakiridis, Kosmas; Korantzis, Ipokratis; Fassiadis, Nikolaos; Zarogoulidis, Konstantinos

2015-01-01

222

Endoscopic transforaminal thoracic foraminotomy and discectomy for the treatment of thoracic disc herniation.  

PubMed

Thoracic disc herniation is a relatively rare yet challenging-to-diagnose condition. Currently there is no universally accepted optimal surgical treatment for symptomatic thoracic disc herniation. Previously reported surgical approaches are often associated with high complication rates. Here we describe our minimally invasive technique of removing thoracic disc herniation, and report the primary results of a series of cases. Between January 2009 and March 2012, 13 patients with symptomatic thoracic disc herniation were treated with endoscopic thoracic foraminotomy and discectomy under local anesthesia. A bone shaver was used to undercut the facet and rib head for foraminotomy. Discectomy was achieved by using grasper, radiofrequency, and the Holmium-YAG laser. We analyzed the clinical outcomes of the patients using the visual analogue scale (VAS), MacNab classification, and Oswestry disability index (ODI). At the final follow up (mean: 17 months; range: 6-41 months), patient self-reported satisfactory rate was 76.9%. The mean VAS for mid back pain was improved from 9.1 to 4.2, and the mean ODI was improved from 61.0 to 43.8. One complication of postoperative spinal headache occurred during the surgery and the patient was successfully treated with epidural blood patch. No other complications were observed or reported during and after the surgery. PMID:24455232

Nie, Hong-Fei; Liu, Kai-Xuan

2013-01-01

223

Updated Perspectives on Neurogenic Thoracic Outlet Syndrome  

Microsoft Academic Search

Pain represents a foremost feature of neurogenic thoracic outlet syndrome (NTOS). Similar to other persistent pain conditions,\\u000a the physical discomfort associated with NTOS can cause severe and often debilitating symptoms. In fact, those suffering from\\u000a the syndrome report a quality of life impacted as significantly as those with chronic heart failure. This evidence-based literature\\u000a review focuses on the classification, etiology,

Paul J. Christo; Kai McGreevy

2011-01-01

224

Fractures of the Thoracic and Lumbar Spine  

Microsoft Academic Search

\\u000a Injuries of the thoracic and lumbar spine in children are rare. The potential for continued growth, the presence of healthy\\u000a disc tissue, the elasticity of the soft tissues, and well-mineralized bone distinguish these injuries from those in the adult.\\u000a The immature spine has the capacity to remodel the vertebral body, but not the posterior elements. Restoration of height of\\u000a a

Robert N. Hensinger; Clifford L. Craig

225

Malignant and benign thoracic tumors during pregnancy.  

PubMed

Eight female patients 23-38 years of age are presented who were pregnant and had concomitant thoracic tumors. The tumors were of a variety of cell types, both malignant and benign, causing chest pain, dyspnea, shock, hemoptysis, and mass formation. Surgical intervention, cobalt radiation, and chemotherapy led to survival and cure of both the mothers and the children. An aggressive approach is recommended. PMID:17436612

Dieter, Raymond A; Kuzycz, George B; Dieter, Raymond A

2006-01-01

226

Managing Dissections of the Thoracic Aorta  

PubMed Central

Thoracic aortic dissection is associated with substantial morbidity and mortality, and it requires timely and accurate diagnosis and treatment. Long-term antihypertensive therapy remains critical for the treatment of this disease. Surgical intervention, although still a formidable undertaking, has evolved to better address both acute and chronic dissection, and the results have improved. Basic and clinical research, as well as technological advances, have increased our understanding of this challenging disease state. PMID:18481490

WONG, DANIEL R.; LEMAIRE, SCOTT A.; COSELLI, JOSEPH S.

2010-01-01

227

Supraclavicular Approach for Thoracic Outlet Syndrome  

Microsoft Academic Search

The authors' experience with the supraclavicular approach for the treatment of patients with primary thoracic outlet syndrome\\u000a (TOS) and for patients with recurrent TOS or iatrogenic brachial plexus injury after prior transaxillary first rib resection\\u000a is presented. The records of 33 patients (34 plexuses) with TOS who presented for evaluation and treatment were analyzed.\\u000a Of these, 12 (35%) plexuses underwent

Julia K. Terzis; Zinon T. Kokkalis

2010-01-01

228

Diaphragm mechanics in dogs with unilateral emphysema.  

PubMed Central

We studied dogs with unilateral papain-induced emphysema to answer two questions: (1) Do emphysema lung-apposed hemidiaphragm (DiE) and normal lung-apposed hemidiaphragm (DiN) have equal capacities for lowering lung surface pressure? and (2) Are side-to-side differences in intrathoracic pressure the result of unequal force outputs by DiE and DiN or are they caused by differences in their mechanical efficiency as pressure generators? After the airways of the emphysematous and normal lungs were intubated with a dual lumen endotracheal tube, both phrenic nerves were maximally stimulated at rates between 1 and 50 Hz and the changes in airway occlusion pressure (delta PaoE,N) and diaphragm length (sonomicrometry) were recorded. In all animals, delta PaoN exceeded delta PaoE. Differences in pressure ranged from 1.2 +/- 0.6 cm H2O during a twitch to 6.0 +/- 2.9 cm H2O during a 50-Hz tetanus. Midcostal bundles of DiE shortened less than corresponding bundles of DiN, but both reached the same active length relative to their optimal lengths, which were measured in vitro. There was no significant difference in fiber type distribution, fiber cross-sectional area, or maximal isometric tetanic tensions among midcostal regions of DiE and DiN. We conclude that unilateral hyperinflation impairs the mechanical efficiency of the apposing hemidiaphragm as a pressure generator. PMID:8473503

Hubmayr, R D; Farkas, G A; Tao, H Y; Sieck, G C; Margulies, S S

1993-01-01

229

Unilateral humeral lengthening in children and adolescents.  

PubMed

This study evaluates our early experience with unilateral humeral lengthening in children and adolescents. From 1995 till 2001, 16 cases with unilateral humeral shortening ranging from 5.5 to 15 cm were referred to our center. The cause was Erb's palsy in eight cases, epiphyseal injury in five cases and infection in three cases. The average age at operation was 13 years (range 8.5-17 years). Hybrid fixation using wires and half pins were applied to all cases to minimize the risk of operative neurovascular complications. Osteotomy was performed in the middle third of the humerus through a posterior approach. After a latent period of 5-7 days lengthening started at a rate of 0.33 mm every 8 h. At an average follow up of 3 years and 2 months (range 1 year and 4 months to 5 years and 6 months) there were 10 excellent and six good results. The average healing index was 28 days/cm. Complications included pin tract infection in all cases; radial nerve palsy in one patient whose humerus overlengthened by 2 cm but improved completely after compression; fracture of the regenerate in two cases. PMID:16200022

Hosny, Gamal Ahmed

2005-11-01

230

Spondylolisthesis of the thoracic spine. Case report.  

PubMed

The thoracic spine is stabilized in the anteroposterior direction by the rib cage and the facet joints. Spondylolisthesis of the thoracic spine is less common than that of the lumbar spine. The authors describe a rare case of thoracic spondylolisthesis in which the patient suffered back pain and myelopathy. The patient was a 44-year-old woman. Plain radiography revealed Grade I T11-12 spondylolisthesis. The pedicle-facet joint angle at T-11 was 118 degrees, greater than that of T-10 or T-12. Postmyelography computerized tomography scanning revealed posterior compression of the dural sac as well as enlargement of and degenerative changes in the facet joint at T-11. Magnetic resonance imaging showed anterior and posterior compression of the spinal cord at the level of the spondylolisthesis. To achieve posterior T10-12 decompression, the surgeons performed a laminectomy and posterolateral fusion in which a pedicle screw fixation system was placed. The patient's back pain disappeared immediately after the operation. The authors conclude that the enlargement of the pedicle-facet joint angle and the degenerative changes of the facet joint caused the thoracolumbar spondylolisthesis. PMID:16703910

Shimada, Yoichi; Kasukawa, Yuji; Miyakoshi, Naohisa; Hongo, Michio; Ando, Shigeru; Itoi, Eiji

2006-05-01

231

[Videothoracospy in thoracic trauma and penetrating injuries].  

PubMed

Videothoracoscopy represents a valid and useful approach in some patients with blunt chest trauma or penetrating thoracic injury. This technique has been validated for the treatment of clotted hemothorax or posttraumatic empyema, traumatic chylothorax, traumatic pneumothorax, in patients with hemodynamic stability. Moreover, it is probably the most reliable technique for the diagnosis of diaphragmatic injury. It is also useful for the extraction of intrathoracic projectiles and foreign bodies. This technique might be useful in hemodynamically stable patients with continued bleeding or for the exploration of patients with penetrating injury in the cardiac area, although straightforward data are lacking to confirm those indications. Thoracotomy or median sternotomy remain indicated in patients with hemodynamic instability or those that cannot tolerate lateral decubitus position or one-lung ventilation. Performing video-surgery in the trauma setting require expertise in both video-assisted thoracic surgery and chest trauma management. The contra-indications to videothoracoscopy and indications for converting the procedure to an open thoracotomy should be perfectly known by surgeons performing video-assisted thoracic surgery in the trauma setting. Conversion to thoracotomy or median sternotomy should be performed without delay whenever needed to avoid blood loss and achieve an adequate procedure. PMID:12657542

Lang-Lazdunski, L; Chapuis, O; Pons, F; Jancovici, R

2003-03-01

232

Bilateral Effects of Unilateral Cochlear Implantation in Congenitally Deaf Cats  

E-print Network

Bilateral Effects of Unilateral Cochlear Implantation in Congenitally Deaf Cats Jahn N. O'Neil,1-month-old con- genitally deaf cats received unilateral cochlear implants and were stimulated for a period of 10­19 weeks by using human speech processors. Implanted cats exhib- ited acoustic startle

Ryugo, David K.

233

Did Unilateral Divorce Raise Divorce Rates? Evidence from Panel Data  

Microsoft Academic Search

This paper revisits the evidence on the impact of unilateral divorce laws on divorce rates in the United States. Most states switched from requiring mutual consent to allowing unilateral or no-fault divorce between 1970 and 1985, while the national divorce rate more than doubled after 1965. According to the Coase theorem, however, the legal shift should have had no effect

Leora Friedberg

1998-01-01

234

Postural stability and unilateral posterior crossbite: Is there a relationship?  

Microsoft Academic Search

The aim of this study was to test the hypothesis that unilateral posterior crossbite influences postural stability of the whole body. Twenty-six subjects (14 males and 12 females) affected with unilateral posterior crossbite were selected and compared with 52 controls matched for age and gender. Postural stability was assessed using a stabilometric platform. The following stabilometric measurements were assessed: weight

Ambrosina Michelotti; Gerarda Buonocore; Mauro Farella; Gioacchino Pellegrino; Carlo Piergentili; Stefano Altobelli; Roberto Martina

2006-01-01

235

Should lung volume reduction for emphysema be unilateral or bilateral?  

Microsoft Academic Search

Both unilateral and bilateral lung volume reduction procedures are being advocated for treatment of severe, generalized emphysema. We analyzed the results of 166 consecutive patients who underwent unilateral (n = 87) or bilateral (n = 79) thoracoscopic stapled lung volume reductions to help define the role for these procedures. There was no statistically significant difference in the operative mortality (3.5%

Robert J. McKenna; Matthew Brenner; Richard J. Fischel; Arthur F. Gelb

1996-01-01

236

Thoracic endovascular aortic repair: are we approaching total endovascular solutions for thoracic aortic disease?  

PubMed

Thoracic endovascular aortic repair (TEVAR) has become an attractive alternative treatment option for thoracic aortic disease. New devices and advanced image-guided procedures are continuously expanding the indications. This article focuses on currently available endovascular solutions for thoracic aortic disease and future 'all endovascular' directions of TEVAR. Currently available endovascular solutions, such as hybrid operations, chimney stent grafting and transapical stent graft deployment, for ascending aortic pathologies are presented. Additionally, the impact of upcoming new technologies, such as endovascular treatment of Stanford Type A dissections of the ascending aorta, is elaborated. With improving device technology, diverse available stent grafts and imaging modalities, TEVAR has become safer and holds promising potential to expand treatment options, especially for the ascending aorta and the aortic arch. PMID:25012992

Shah, Aamir; Bombien, René; Khoynezhad, Ali

2014-01-01

237

Genetics Home Reference: Asphyxiating thoracic dystrophy  

MedlinePLUS

... Cilia also play an important role in the perception of sensory input (such as sight, hearing, and ... chromosome ; cysts ; dysplasia ; gene ; incidence ; inherited ; kidney ; pancreatic ; perception ; polydactyly ; protein ; recessive ; renal ; stenosis ; syndrome You may ...

238

Radiation response of the monkey kidney following contralateral nephrectomy  

SciTech Connect

The long-term functional and morphologic responses of the hypertrophied monkey kidney after unilateral nephrectomy to fractionated irradiation were assessed. The right kidney of 13 adult female rhesus monkeys was removed. Twelve weeks after unilateral nephrectomy (UN) the remaining kidney received fractionated doses of {gamma}-rays ranging from 35.2 Gy/16 fractions (F) up to 44 Gy/20 F. Glomerular filtration rate, effective renal plasma flow, blood urea nitrogen, serum creatinine, and hematocrit values were measured up to 107 weeks postirradiation (PI). The monkeys were killed and the remaining kidneys were removed 107 weeks PI or earlier when end-stage renal failure was exhibited. Glomeruli were scored for the presence/absence of several pathologic features including increased intercapillary eosinophilic material (ICE), ecstatic capillaries, and thrombi. The relative proportion of renal cortex occupied by glomeruli, interstitium, normal tubules or abnormal tubules was determined using a Chalkley point grid. These quantal dose response data were analyzed using a logistic regression model. Irradiation of the remaining kidney in UN monkeys resulted in a dose-dependent reduction in renal function and anemia. Glomerular dysfunction preceded tubular dysfunction. Animals receiving 44 Gy all manifested progressive clinical renal failure. Conversely, those receiving {le} 39.6 Gy showed stable, albeit impaired, renal function for the duration of the observation period of 107 weeks. Morphologically, the incidence of ICE, ecstatic glomerular capillaries, thrombi, and periglomerular fibrosis was significantly dose-related (p < 0.005). A significant (p < 0.001) dose-related increase in the relative proportion of renal cortex occupied by abnormal tubules was indicative of tubular injury. A highly significant (p < 0.001) dose-dependent increase in the proportion of abnormal to normal tubules was also seen. 27 refs., 4 figs., 2 tabs.

Robbins, M.E.C. [Research Institute, Oxford (United Kingdom); Stephens, L.C.; Gray, K.N. [Univ. of Texas M.D. Anderson Cancer Center, Houston, TX (United States)] [and others

1994-09-30

239

Financial Help for Treatment of Kidney Failure  

MedlinePLUS

... of Kidney Failure Financial Help for Treatment of Kidney Failure On this page: How costly is kidney ... About the Kidney Failure Series How costly is kidney failure treatment? Kidney failure treatment—hemodialysis, peritoneal dialysis, ...

240

Internal thoracic artery: anatomical and biological characteristics revisited.  

PubMed

The left internal thoracic artery has become the conduit of choice for coronary artery bypass grafting, due to its superior patency rates at 10 or more years with little or no evidence of atherosclerotic changes. Recent evidence indicates that a second internal thoracic artery graft provides improved results relative to overall survival and major cardiac and cerebrovascular event-free survival, and reduces the need for repeat revascularization. However, the routine use of bilateral internal thoracic arteries is limited due to a perceived higher incidence of deep sternal wound infection. The surgical anatomy, collateral blood supply to the sternum, and biological characteristics of internal thoracic artery conduits are reviewed. PMID:24585304

Sajja, Lokeswara Rao; Mannam, Gopichand

2015-01-01

241

Evaluation of renal function after successful treatment for unilateral, non-syndromic Wilms tumor.  

PubMed

Impaired renal function may occur in experimental animals following surgical removal of most functioning renal tissue ("hyperfiltration injury"). Although end-stage renal disease is uncommon among long-term survivors of unilateral, non-syndromic Wilms tumor, concern has been expressed that there may be an increased risk of less serious, but progressive, renal function impairment among these individuals. The recent development of equations for estimating glomerular filtration rate (eGFR) has facilitated the study of renal function in Wilms tumor survivors. However, the estimating equations were developed to categorize individuals with chronic kidney disease and have significant limitations with regard to the accuracy of individual GFR estimates. These limitations must be considered when utilizing the estimating equations in cross-sectional or longitudinal evaluations of renal function in cohorts of patients who have been treated successfully for Wilms tumor or other childhood cancers. PMID:24039069

Green, Daniel M

2013-12-01

242

Unilateral temporomandibular joint ankylosis with contralateral aplasia  

PubMed Central

The temporomandibular joint (TMJ) is considered as one of the complex joints of the human body. Mandibular condylysis is distinguished from condylar aplasia by its non-association with aural/facial anomalies, and also as normal development appears to proceed until the lytic event occurs. It is further distinguished from primary and secondary condylar hypoplasia by the following: Absence of condyle rather than it being small, the normal development appears to proceed until the lytic event occurs, and its non-association with aural/facial anomalies or temporomandibular ankylosis. In the present report, a patient with a unilateral missing mandibular condyle with contralateral TMJ ankylosis is presented and the treatment is outlined and discussed. PMID:24665190

Singh, Nimisha; Pal, U. S.; Mohammad, S.; Singh, R. K.; Mehta, Gagan; Makadia, Hardik S.

2013-01-01

243

Unilateral lichen planus: A rare case report  

PubMed Central

Oral lichen planus (OLP) is a mucocutaneous disease with well-established clinical and histopathological features. It has a prevalence of approximately 1%. The etiopathogenesis is poorly understood. The annual malignant transformation is less than 0.5%. There are no effective means to either predict or to prevent such event. Clinically, OLP present as bilateral symmetrical lesion and hence lichen planus isolated to a single oral site other than the gingiva is very uncommon. On the other hand lichenoid reaction (LR) are the lesions which are similar clinically and histopathologically with OLP, but they are induced with some drug reaction and usually they do not show bilateral pattern like lichen planus. We reported a very uncommon case of unilateral lichen planus which was clinically diagnosed as LR, but in the absence of any cause-effective relationship biopsy was taken for histopathological examination Histopathologically, LR cannot be differentiated with OLP, so the final diagnosis was made on the immunohistochemical ground. PMID:25097434

Bajpai, Manas; Agarwal, Deshant; Bhalla, Anindya; VatchalaRani, R. M.; Kumar, Malay

2014-01-01

244

Tear Condition Following Unilateral Ptosis Surgery.  

PubMed

Abstract Purpose: To evaluate changes in tear film condition following unilateral ptosis surgery. Methods: This interventional case series includes patients with unilateral blepharoptosis scheduled for ptosis surgery with no prior history of eye disease and surgery over a 2-year period. Tear film evaluation before surgery were performed, which included Schirmer test with and without anesthesia, and tear break up time (TBUT). Ptosis surgery included levator resection and frontalis sling. The previously mentioned tests were repeated 1, 3, and 6 months after surgery. Subjective symptoms related to dry eye also evaluated before and after surgery. Results: A total of 83 patients including 46 (55.4%) male subjects with mean age of 26.2?±?16.2 years were enrolled in the study. The most common cause of ptosis was congenital in 77 (92.8%) patients. Surgical intervention included levator resection in 56 (67.5%) cases and frontalis sling procedure in 27 (32.5%) cases. The result of surgery was good in 47 (56.6%) patients while under- and overcorrection were observed in 32 (39.8%) and 3 (3.6%) patients, respectively. Schirmer's test with and without anesthesia and TBUT after surgery revealed a decrease in tear quantity and quality after surgery with time. Patients who had subjective complaints from dryness after surgery only had shorter TBUT among the objective signs. Conclusions: Ptosis surgery can decrease the quantity and quality of tears in operated eyes. Since some of these patients may need other types of operations in future, such as refractive or cataract surgery, evaluation of the tear condition before further surgery is prudent. PMID:25474275

Bagheri, Abbas; Najmi, Hadi; Salim, Reza Erfanian; Yazdani, Shahin

2014-12-01

245

Isolated unilateral rupture of the alar ligament.  

PubMed

Only 6 cases of isolated unilateral rupture of the alar ligament have been previously reported. The authors report a new case and review the literature, morbid anatomy, and pathogenesis of this rare injury. The patient in their case, a 9-year-old girl, fell head first from a height of 5 feet off the ground. She presented with neck pain, a leftward head tilt, and severe limitation of right rotation, extension, and right lateral flexion of the neck. Plain radiographs and CT revealed no fracture but a shift of the dens toward the right lateral mass of C-1. Magnetic resonance imaging of the cervical spine showed signal hyperintensity within the left dens-atlas space on both T1- and T2-weighted sequences and interruption of the expected dark signal representing the left alar ligament, suggestive of its rupture. After 12 weeks of immobilization in a Guilford brace, MRI showed lessened dens deviation, and the patient attained full and painless neck motion. Including the patient in this case, the 7 patients with this injury were between 5 and 21 years old, sustained the injury in traffic accidents or falls, presented with marked neck pain, and were treated with external immobilization. All patients had good clinical outcome. The mechanism of injury is hyperflexion with rotation. Isolated unilateral alar ligament rupture is a diagnosis made by excluding associated fracture, dislocation, or disruption of other major ligamentous structures in the craniovertebral junction. CT and MRI are essential in establishing the diagnosis. External immobilization is adequate treatment. PMID:24679079

Wong, Sui-To; Ernest, Kimberly; Fan, Grace; Zovickian, John; Pang, Dachling

2014-05-01

246

L-Endoglin Overexpression Increases Renal Fibrosis after Unilateral Ureteral Obstruction  

PubMed Central

Transforming growth factor-? (TGF-?) plays a pivotal role in renal fibrosis. Endoglin, a 180 KDa membrane glycoprotein, is a TGF-? co-receptor overexpressed in several models of chronic kidney disease, but its function in renal fibrosis remains uncertain. Two membrane isoforms generated by alternative splicing have been described, L-Endoglin (long) and S-Endoglin (short) that differ from each other in their cytoplasmic tails, being L-Endoglin the most abundant isoform. The aim of this study was to assess the effect of L-Endoglin overexpression in renal tubulo-interstitial fibrosis. For this purpose, a transgenic mouse which ubiquitously overexpresses human L-Endoglin (L-ENG+) was generated and unilateral ureteral obstruction (UUO) was performed in L-ENG+ mice and their wild type (WT) littermates. Obstructed kidneys from L-ENG+ mice showed higher amounts of type I collagen and fibronectin but similar levels of ?-smooth muscle actin (?-SMA) than obstructed kidneys from WT mice. Smad1 and Smad3 phosphorylation were significantly higher in obstructed kidneys from L-ENG+ than in WT mice. Our results suggest that the higher increase of renal fibrosis observed in L-ENG+ mice is not due to a major abundance of myofibroblasts, as similar levels of ?-SMA were observed in both L-ENG+ and WT mice, but to the higher collagen and fibronectin synthesis by these fibroblasts. Furthermore, in vivo L-Endoglin overexpression potentiates Smad1 and Smad3 pathways and this effect is associated with higher renal fibrosis development. PMID:25313562

Arévalo, Miguel; Núñez-Gómez, Elena; Pérez-Roque, Lucía; Pericacho, Miguel; González-Núñez, María; Langa, Carmen; Martínez-Salgado, Carlos; Perez-Barriocanal, Fernando; Bernabeu, Carmelo; Lopez-Novoa, José M.

2014-01-01

247

Expanding upon the unilateral hyperlucent hemithorax in children.  

PubMed

Unilateral hyperlucent hemithorax is a common pediatric chest radiographic finding that may also be seen at computed tomography. It may result from congenital or acquired conditions involving the pulmonary parenchyma, airway, pulmonary vasculature, pleural space, and chest wall, as well as from technical factors such as patient rotation. Unilateral hyperlucent hemithorax has a broad differential diagnosis that includes unilateral emphysematous or bullous disease, pneumatocele, foreign body aspiration, Swyer-James syndrome, congenital lobar emphysema, endobronchial mass, unilateral pulmonary agenesis, proximal interruption of the pulmonary artery, scimitar syndrome, diaphragmatic hernia, and Poland syndrome. Although certain causes of unilateral hyperlucent hemithorax are clinically significant and potentially life threatening, others are of minimal or no clinical significance. When evaluating a patient with this finding, it is important to establish whether the apparent unilateral hyperlucent hemithorax is truly too lucent (hypoattenuating) or if the contralateral hemithorax is too opaque (hyperattenuating). It is imperative that radiologists be aware of the various causes of unilateral hyperlucent hemithorax so that they may diagnose the underlying condition and appropriately guide patient management. PMID:21571653

Dillman, Jonathan R; Sanchez, Ramon; Ladino-Torres, Maria F; Yarram, Sai G; Strouse, Peter J; Lucaya, Javier

2011-01-01

248

Emergent Repair of Acute Thoracic Aortic Catastrophes  

PubMed Central

Objective To provide a contemporary institutional comparative analysis of expedient correction of acute catastrophes of the descending thoracic aorta (ACDTA) by traditional direct thoracic aortic repair (DTAR) or thoracic endovascular aortic repair (TEVAR). Design Single-center retrospective review (April 2001-January 2010). Setting Academic medical center. Patients One hundred patients with ACDTA treated with either TEVAR (n=76) or DTAR (n=24). Indications for repair included ruptured degenerative aneurysm (n = 41), traumatic transection (n = 27), complicated acute type B dissection (n=20), penetrating ulcer (n=4), intramural hematoma (n=3), penetrating injury (n=3), and embolizing lesion (n=2). Main Outcome Measures Demographics and 30-day and late outcomes were analyzed using multivariate analysis over a mean follow-up of 33.8 months. Results Among the 100 patients, mean (SD) age was 58.5 (17.3) years (range, 18–87 years). Demographics and comorbid conditions were similar between the 2 groups, except more patients in the DTAR group had prior aortic surgery (P=.02) and were older (P=.01). Overall 30-day mortality was significantly better among the TEVAR group (8% vs 29%; P=.007). Incidence of postoperative myocardial infarction, acute renal failure, stroke, and paraplegia/paresis was similar between the 2 treatment groups (TEVAR, 5%, 12%, 8%, and 8% vs DTAR, 13%, 13%, 9%, and 13%, respectively). Major respiratory complications were lower in the TEVAR group (16% vs 48%; P<.05). Mean length of hospital stay was also shorter after TEVAR (13.5 vs 16.3 days; P=.30). Independent predictors of patient mortality included age (P=.004) and DTAR (P=.001). Conclusion Patients presenting with ACDTA are best treated with TEVAR whenever feasible. PMID:22430904

Naughton, Peter A.; Park, Michael S.; Morasch, Mark D.; Rodriguez, Heron E.; Garcia-Toca, Manuel; Wang, C. Edward; Eskandari, Mark K.

2014-01-01

249

Persistent High Level of Urinary Tumor Marker Carbohydrate Antigen 19-9 in Prenatally Diagnosed Dysplastic Kidney  

PubMed Central

Tumor marker carbohydrate antigen 19-9 (CA 19-9) level has gained clinical significance in gastrointestinal malignancies and in various solid and cystic diseases. Dysplastic kidney is a congenital abnormality resulting from atresia of the ureteral bud during the embryogenesis which can be unilateral or bilateral. We report unilateral dysplastic kidney with extremely large cyst diagnosed by routine ultrasonography in the 32nd week of gestational age with high levels of CA 19-9 in cystic and amniotic fluid, as well as persistent high urinary levels of this tumor marker during the 1-year follow-up. Persistent high urinary CA 19-9 level even after cyst aspiration may be attributable to remained function of dysplastic kidney due to remained epithelial lining. PMID:25614848

Ebadi, Maryam; Rahimi Sherbaf, Fatemeh; Kajbafzadeh, Abdol-Mohammad

2014-01-01

250

Kidney Health Eating Right for  

E-print Network

Kidney Health Eating Right for National Kidney Disease Education Program Tips for People with Chronic Kidney Disease (CKD) hat you eat and drink can help slow down chronic kidney disease. Some foods are better for your kidneys than others. Cooking and preparing your food from scratch can help you eat

Bandettini, Peter A.

251

"Kidney Health" Deaf Health Talks  

E-print Network

"Kidney Health" Deaf Health Talks September 22, 2010 #12;Supporters Deaf Health Community Committee Recreation Club for the Deaf ("REAP") #12;Overview What do kidneys do for us? What are common causes for kidney failure? What are common causes for kidney stones? How can we protect our kidneys? #12;Quiz How

Goldman, Steven A.

252

Obstructed Bifid Uretereric System Causing Unilateral Hydronephrosis  

PubMed Central

Bifid ureters are a common malformation of the urinary system. In clinical practice, hydronephrosis resulting from obstruction of such a system is rare. The authors present a case involving an 88-year-old man admitted to the hospital with symptoms of renal failure, where bifid ureters were found incidentally in a hydronephrotic kidney during an emergency nephrostomy. This had been missed on a previous CT scan, resulting in a unique therapeutic dilemma. PMID:24223026

Bhamani, Amyn; Srivastava, Manoj

2013-01-01

253

Recent advances in radiotherapy for thoracic tumours  

PubMed Central

Radiation Oncology technology has continued to advance at a rapid rate and is bringing significant benefits to patients. This review outlines some of the advances in technology and radiotherapy treatment of thoracic cancers including brachytherapy, stereotactic radiotherapy, tomotherapy and intensity modulated radiotherapy. The importance of functional imaging with PET and management of movement are highlighted. Most of the discussion relates to non-small cell lung cancer but management of mesothelioma and small cell lung cancer are also covered. This technology has substantial benefits to patients in terms of decreasing toxicity both in the short and longer term. PMID:24163747

Poole, Christopher M.; Pratt, Gary

2013-01-01

254

Video-assisted thoracic surgery complications  

PubMed Central

Video-assisted thoracic surgery (VATS) is a miniinvasive technique commonly applied worldwide. Indications for VATS are very broad and include the diagnosis of mediastinal, lung and pleural diseases, as well as large resection procedures such as pneumonectomy. The most frequent complication is prolonged postoperative air leak. The other significant complications are bleeding, infections, postoperative pain and recurrence at the port site. Different complications of VATS procedures can occur with variable frequency in various diseases. Despite the large number of their types, such complications are rare and can be avoided through the proper selection of patients and an appropriate surgical technique. PMID:25561984

Kozak, Józef

2014-01-01

255

Thoracic Outlet Syndrome Following Breast Implant Rupture  

PubMed Central

Summary: We present a patient with bilateral breast implant rupture who developed severe locoregional silicone granulomatous lymphadenopathy. Poly Implant Prothese silicone implants had been used for bilateral breast augmentation 5 years prior. Extracapsular implant rupture and bilateral axillary lymphadenopathy indicated explantation, capsulectomy, and selective lymph node excision. Histology demonstrated silicone lymphadenopathy with no evidence of malignancy. Over the subsequent 12 months, she developed progressive locoregional lymphadenopathy involving bilateral cervical, axillary, and internal mammary groups, resulting in bilateral thoracic outlet syndrome. We report the unusual presentation, progression, and the ultimate surgical management of this patient. PMID:25878942

Caplash, Yugesh; Giri, Pratyush; Kearney, Daniel; Wagstaff, Marcus

2015-01-01

256

Bypass Surgery in Arterial Thoracic Outlet Syndrome  

PubMed Central

Arterial thoracic outlet syndrome (TOS) causes ischemic symptoms; it is the rarest type, occurring in 5% of all TOS cases. This paper is a case report of a 38-year-old male patient diagnosed with arterial TOS, displaying symptoms of acute critical limb ischemia caused by thromboembolism. Brachial artery of the patient has been diffusely damaged by repeated occurrence of thromboembolism. It was thought to be not enough only decompression of subclavian artery to relieve the symptoms of hand ischemia; therefore, bypass surgery using reversed great saphenous vein was performed.

Bae, Miju; Lee, Chung Won; Chung, Sung Woon; Choi, Jinseok; Kim, Min Su

2015-01-01

257

Kidney Replacement Therapy  

MedlinePLUS

... Complications Neuropathy Foot Complications DKA (Ketoacidosis) & Ketones Kidney Disease (Nephropathy) Gastroparesis Mental Health Treatment & Care Blood Glucose Testing Medication Doctors, Nurses & More ...

258

Kidney Disease (Nephropathy)  

MedlinePLUS

... Complications Neuropathy Foot Complications DKA (Ketoacidosis) & Ketones Kidney Disease (Nephropathy) Gastroparesis Mental Health Treatment & Care Blood Glucose Testing Medication Doctors, Nurses & More ...

259

Papillary Kidney Carcinoma  

Cancer.gov

The most common type of kidney cancer is called renal cell carcinoma. This cancer forms in the cells lining the small tubules in the kidney that filter waste from the blood and make urine. An estimated 58,240 Americans were expected to have been diagnosed with kidney cancer in 2010 and an estimated 13,040 to have died of this cancer.1 Most people with kidney cancer are usually over 55 years of age and this cancer is more common in men.

260

Clear Cell Kidney Carcinoma  

Cancer.gov

The most common type of kidney cancer is called renal cell carcinoma. This cancer forms in the cells lining the small tubules in the kidney that filter waste from the blood and make urine. An estimated 58,240 Americans were expected to have been diagnosed with kidney cancer in 2010 and an estimated 13,040 to have died of this cancer.1 Most people with kidney cancer are usually over 55 years of age and this cancer is more common in men.

261

Medullary cystic kidney disease  

MedlinePLUS

Anemia Bone weakening and fractures Cardiac tamponade Changes in glucose metabolism Congestive heart failure End-stage kidney disease Gastrointestinal bleeding, ulcers Hemorrhage (excessive bleeding) High ...

262

Assessment of Renal Function in Patients with Unilateral Ureteral Obstruction Using Whole-Organ Perfusion Imaging with 320-Detector Row Computed Tomography  

PubMed Central

Background Obstructed nephropathy is a common complication of several disease processes. Accurate evaluation of the functional status of the obstructed kidney is important to achieve a good outcome. The purpose of this study was to investigate renal cortical and medullary perfusion changes associated with unilateral ureteral obstruction (UUO) using whole-organ perfusion imaging with 320-detector row computed tomography (CT). Methodology/Principle Findings Sixty-four patients with UUO underwent whole-organ CT perfusion imaging. Patients were divided into 3 groups, mild, moderate, and severe, based on hydronephrosis severity. Twenty sex- and age-matched patients without renal disease, who referred to abdominal CT, were chosen as control subjects. Mean cortical and medullary perfusion parameters of obstructed and contralateral kidneys were compared, and mean perfusion ratios between obstructed and contralateral kidneys were calculated and compared. Mean cortical or medullary blood flow (BF) and blood volume (BV) of the obstructed kidneys in the moderate UUO and BF, BV, and clearance (CL) in the severe UUO were significantly lower than those of the contralateral kidneys (p < 0.05). The mean cortical or medullary BF of the obstructed kidney in the moderate UUO, and BF, BV, and CL in the severe UUO were significantly lower than those of the kidneys in control subjects (p < 0.05). Mean cortical or medullary BF of the non-obstructed kidneys in the severe UUO were statistically greater than that of normal kidneys in control subjects (p < 0.05). An inverse correlation was observed between cortical and medullary perfusion ratios and grades of hydronephosis (p < 0.01). Conclusions/Significance Perfusion measurements of the whole kidney can be obtained with 320-detector row CT, and estimated perfusion ratios have potential for quantitatively evaluating UUO renal injury grades. PMID:25874690

Yu, Juan; Feng, You-Zhen; Xian, Zhao-Hui; Yang, Wen-Cai; Mo, Xu-Kai

2015-01-01

263

Technical Note Functional MRI of the Thoracic Spinal Cord During  

E-print Network

Technical Note Functional MRI of the Thoracic Spinal Cord During Vibration Sensation Jennifer functional magnetic resonance images from thoracic spinal cord neurons. Materials and Methods: The lower spinal cord using a HASTE sequence on a 3 Tesla MRI system. Results: Signal increases were observed

Smith, Stephen D.

264

Is thoracic aortic disease a growing problem in Japan?  

PubMed

An article by Okita was recently published in General Thoracic and Cardiovascular Surgery. The paper thoroughly reviewed the surgical treatments for thoracic aortic disease in Japan. Valve-sparing aortic root operation, cerebral protection during aortic arch aneurysmectomy, and spinal cord protection during thoracoabdominal aneurysm repair are discussed in the present editorial. PMID:25833283

Tabayashi, Koichi

2015-04-01

265

Thoracic meningioma masquerading as chronic abdominal pain.  

PubMed

Chronic abdominal pain without a structural or metabolic gastroenterological etiology can be extremely challenging to diagnose. Patients presenting with an associated radicular pattern of pain may alert the clinician to a possible structural neurological cause of the symptoms. We present the case of a 70-year-old woman who presented to our institution with an 18-month history of right upper quadrant abdominal pain. She had no associated symptoms or provoking factors. She underwent an extensive gastroenterology evaluation, including colonoscopy that was unrevealing. Ultrasound demonstrated gallstones and she was evaluated for cholecystectomy. She subsequently developed right costal margin pain. Her symptoms remained stable over the course of the next year. Follow-up general surgical evaluation was still unconvincing that the gallstones were the etiology of her symptoms. A thoracic spinal MR demonstrated a large intradural extramedullary mass at T8. The patient's neurological exam was normal. She underwent a thoracic laminectomy and resection of meningioma with intraoperative electrophysiological monitoring. Her abdominal pain resolved. Patients can present with months to years of elusive abdominal symptoms only to be eventually found to be harboring an undiagnosed spinal tumor. We discuss the case and review the literature reports of spinal tumors masquerading as chronic abdominal pain. PMID:22665009

Lyons, Mark; Windgassen, Elizabeth; Kinney, Carolyn; Johnson, Daniel; Birch, Barry; Boucher, Orland

2012-01-01

266

Thoracic Ganglioneuromas Resulting in Nonimmune Hydrops Fetalis  

PubMed Central

Introduction?Most often, ganglioneuromas affect older pediatric and adult patients. They are typically slow growing tumors that remain clinically silent until they become large enough to cause symptoms by compression of adjacent structures. Case?We report a case of a 22-year-old Hispanic gravida 2 para 1 female patient who was found to have massive hydrops fetalis at 20 completed gestational weeks. Fetal echocardiography revealed a narrowed distal ductal arch and proximal descending aorta. Cesarean delivery was undertaken at 29 completed gestational weeks for refractory labor and nonreassuring fetal status. The neonate expired at 47 minutes of life despite aggressive resuscitation. At autopsy, multiple thoracic masses were found adjacent to a compressed proximal descending aorta. Histological and immunohistochemical analysis confirmed the diagnosis of a ganglioneuroma, a rare type of neural crest tumor. Discussion?A variety of intrathoracic masses have previously been reported to cause hydrops fetalis including teratomas, fibrosarcomas, and lymphangiomas. To our knowledge, this case is the first description of hydrops fetalis caused by ganglioneuromas. We propose that multiple thoracic ganglioneuromas led to biventricular distal outflow tract obstruction and hydrops fetalis. PMID:25032061

Singh, Paul; Jodicke, Cristiano; Swanson, Tara; Maulik, Dev

2014-01-01

267

Thoracic ganglioneuromas resulting in nonimmune hydrops fetalis.  

PubMed

Introduction?Most often, ganglioneuromas affect older pediatric and adult patients. They are typically slow growing tumors that remain clinically silent until they become large enough to cause symptoms by compression of adjacent structures. Case?We report a case of a 22-year-old Hispanic gravida 2 para 1 female patient who was found to have massive hydrops fetalis at 20 completed gestational weeks. Fetal echocardiography revealed a narrowed distal ductal arch and proximal descending aorta. Cesarean delivery was undertaken at 29 completed gestational weeks for refractory labor and nonreassuring fetal status. The neonate expired at 47 minutes of life despite aggressive resuscitation. At autopsy, multiple thoracic masses were found adjacent to a compressed proximal descending aorta. Histological and immunohistochemical analysis confirmed the diagnosis of a ganglioneuroma, a rare type of neural crest tumor. Discussion?A variety of intrathoracic masses have previously been reported to cause hydrops fetalis including teratomas, fibrosarcomas, and lymphangiomas. To our knowledge, this case is the first description of hydrops fetalis caused by ganglioneuromas. We propose that multiple thoracic ganglioneuromas led to biventricular distal outflow tract obstruction and hydrops fetalis. PMID:25032061

Singh, Paul; Jodicke, Cristiano; Swanson, Tara; Maulik, Dev

2014-05-01

268

Developing the academic thoracic surgeon: teaching surgery.  

PubMed

Teaching surgery can be a very gratifying experience for those of us involved in academic thoracic surgery. Fundamentals of a good residency program require that patients should always be placed in the highest priority. However, the residency program should also be committed to teaching as a priority. Creating the proper operating room environment is essential for optimal conduct of the operation. This environment is similar to that of the airline industry, which is known as crew or cockpit resource management. The design of a teaching program needs to have evaluation as one of its key elements. In addition to resident evaluation, it is also important to have faculty evaluation by the residents. The goal of any residency program should be to foster the development of the future leaders in our specialty. The information contained within this article represents the art and science of teaching thoracic surgery as applied by the faculty in the Division of Cardiac Surgery at The Johns Hopkins Hospital. PMID:10727957

Baumgartner, W A; Greene, P S

2000-04-01

269

Diet for Kidney Stone Prevention  

MedlinePLUS

... Info Statistics Research Resources About Us Español National Kidney and Urologic Diseases Information Clearinghouse Publications Tools and ... Titles : Diet for Kidney Stone Prevention Diet for Kidney Stone Prevention On this page: How does diet ...

270

Kidneys and How They Work  

MedlinePLUS

... Info Statistics Research Resources About Us Español National Kidney and Urologic Diseases Information Clearinghouse Publications Tools and ... Titles : The Kidneys and How They Work The Kidneys and How They Work On this page: What ...

271

African Americans and Kidney Disease  

MedlinePLUS

... Kidney Quiz Rate Your Risk Quiz Featured Story African Americans & Kidney Disease Did you know that African Americans ... NKF Newsroom Contact Us You are here Home » African Americans and Kidney Disease Due to high rates of ...

272

The right sided syndrome, congenital absence of kidney and testis.  

PubMed

Unilateral renal agenesis (URA) is a developmental defect associated with ano-malies of the genitourinary system. The associations vary from absence of testis alone to high anorectal anomalies in other patients. We present two interesting patients with URA, encountered recently. Our first case was diagnosed with URA at the age of 11 years, which was detected on sonography, when he presented with pain abdomen. The presence of an epididymal cyst masked the absence of ipsilateral testes leading to delay in the diagnosis. Our second case was diagnosed with URA during the neonatal period when he presented with anorectal agenesis. He underwent abdomino-anal pull-through operation and later clinical course was complicated by recurrent cystitis, secondary vesicoureteral reflux and hydroureteronephrosis of solitary kidney, progressing to chronic kidney disease. PMID:21422633

Kumar, K V S Hari; Rao, B Srinivas; Shiradhonkar, Shekhar; Jha, Ratan; Narayan, Girish; Modi, K D

2011-03-01

273

Pirfenidone improves renal function and fibrosis in the post-obstructed kidney  

Microsoft Academic Search

Pirfenidone improves renal function and fibrosis in the post-obstructed kidney.BackgroundPirfenidone™ (PFD) is a novel anti-fibrotic agent that can prevent and even reverse extracellular matrix accumulation in several organs, as shown by experimental and clinical studies. Unilateral ureteral obstruction (UUO) is a well-characterized model of experimental renal disease culminating in tubulointerstitial fibrosis.MethodsUUO or sham-operated rats were administered PFD (500 mg\\/kg\\/day) in

Toshikatsu Shimizu; Takayuki Kuroda; Satoshi Hata; Masafumi Fukagawa; Solomon B Margolin; Kiyoshi Kurokawa

1998-01-01

274

Limitation of Imaging in Identifying Iatrogenic Aortic Coarctation following Thoracic Endovascular Aortic Repair.  

PubMed

A 21-year-old male suffered blunt trauma from a motor vehicle accident causing thoracic aorta tear. The smallest available stent graft was deployed. Definitive repair was later performed using a 22 × 22 × 116 mm Talent Thoracic Stent Graft. The postoperative course was uneventful. Seventeen months later, he presented with dizziness, chest pain, acute renal failure, malignant hypertension, and troponin elevation. Computed tomography (CT) angiogram and transesophageal echocardiogram did not reveal any dissection, stent stenosis or collapse. Cardiac catheterization showed normal coronary arteries but a 117 mm Hg gradient across the stent graft. Iatrogenic coarctation of the aorta was confirmed with a second measurement during arch angiogram. A Palmaz stent was deployed over the distal end of the previous stent graft with complete resolution of symptoms and gradual normalization of kidney function. This case report demonstrates a need for wider availability and selecting appropriate stent graft in treating traumatic aortic injuries in young patients. It is the first case report of the inability of current imaging modalities in confirming stent collapse. Pressure gradient is a useful tool in confirming stent collapse when clinical scenario does not match CT findings. PMID:25637574

Thakkar, Rajiv N; Thomaier, Lauren; Qazi, Umair; Verde, Franco; Malas, Mahmoud B

2015-04-01

275

Kidney Surgery Codes  

Cancer.gov

Kidney, Renal Pelvis, and Ureter Kidney C649, Renal Pelvis C659, Ureter C669 (Except for M9727, 9733, 9741-9742, 9764-9809, 9832, 9840-9931, 9945-9946, 9950-9967, 9975-9992) Codes 00 None; no surgery of primary site; autopsy ONLY 10 Local tumor

276

Altruistically Unbalanced Kidney Exchange  

Microsoft Academic Search

Although a pilot national live-donor kidney exchange program was recently launched in the US, the kidney shortage is increasing faster than ever. A new solution paradigm is able to incorporate compatible pairs in exchange. In this paper, we consider an exchange framework that has both compatible and in- compatible pairs, and patients are indifferent over compatible pairs. Only two-way exchanges

Tayfun Sönmez; M. Utku Ünver

2011-01-01

277

Unilateral ureteric stone associated with gross hydronephrosis and kidney shrinkage: a cadaveric report  

PubMed Central

Ureteric stones are a common cause of obstruction of the urinary tract, usually presenting with characteristic signs and symptoms, such as acute ureteric colic and hematuria. Occasionally, stones may present with non-specific symptoms such as low back pain and remain unidentified, leading to stone growth, chronic ureteric obstruction and complications such as hydronephrosis and renal damage. Here, we report a large ureteric stone in a cadaver with complete obstruction at the left ureterovesical junction, resulting in severe dilatation of the left ureter and renal pelvis. PMID:25548725

Tay, Ern-Wei; Bay, Boon-Huat

2014-01-01

278

Unilateral condylar hyperplasia: A case report and review of literature  

PubMed Central

Condylar hyperplasia is (CH) an uncommon malformation of the mandible involving change in size and morphology of the condylar neck and head. CH is an anomaly that usually occurs unilaterally and equally affects in both men and women. Hyperplasia of the condyle ‘differentiated into hemimandibular hyperplasia, hemimandibular elongation and CH. Here, we are presenting a case of 17-year-old male patient with unilateral CH and its review of the literature. PMID:24818099

Bharathi, Saravana C.; Senthilnathan, S.; Kumar, Lokesh D.; Mohan, Anand C. S.; Taranath, M.

2014-01-01

279

Grip Force Coordination during Bimanual Tasks in Unilateral Cerebral Palsy  

ERIC Educational Resources Information Center

Aim: The aim of the study was to investigate coordination of fingertip forces during an asymmetrical bimanual task in children with unilateral cerebral palsy (CP). Method: Twelve participants (six males, six females; mean age 14y 4mo, SD 3.3y; range 9-20y;) with unilateral CP (eight right-sided, four left-sided) and 15 age-matched typically…

Islam, Mominul; Gordon, Andrew M.; Skold, Annika; Forssberg, Hans; Eliasson, Ann-Christin

2011-01-01

280

Epigallocatechin-3-gallate attenuates unilateral ureteral obstruction-induced renal interstitial fibrosis in mice.  

PubMed

The severity of tubulointerstitial fibrosis is regarded as an important determinant of renal prognosis. Therapeutic strategies targeting tubulointerstitial fibrosis have been considered to have potential in the treatment of chronic kidney disease. This study aims to evaluate the protective effects of (-)-epigallocatechin-3-gallate (EGCG), a green tea polyphenol, against renal interstitial fibrosis in mice. EGCG was administrated intraperitoneally for 14 days in a mouse model of unilateral ureteral obstruction (UUO). The results of our histological examination showed that EGCG alleviated glomerular and tubular injury and attenuated renal interstitial fibrosis in UUO mice. Furthermore, the inflammatory responses induced by UUO were inhibited, as represented by decreased macrophage infiltration and inflammatory cytokine production. Additionally, the expression of type I and III collagen in the kidney were reduced by EGCG, which indicated an inhibition of extracellular matrix accumulation. EGCG also caused an up-regulation in ?-smooth muscle actin expression and a down-regulation in E-cadherin expression, indicating the inhibition of epithelial-to-mesenchymal transition. These changes were found to be in parallel with the decreased level of TGF-?1 and phosphorylated Smad. In conclusion, the present study demonstrates that EGCG could attenuate renal interstitial fibrosis in UUO mice, and this renoprotective effect might be associated with its effects of inflammatory responses alleviation and TGF-?/Smad signaling pathway inhibition. PMID:25549657

Wang, Yanqiu; Wang, Bowen; Du, Feng; Su, Xuesong; Sun, Guangping; Zhou, Guangyu; Bian, Xiaohui; Liu, Na

2015-04-01

281

Iron chelation by deferoxamine prevents renal interstitial fibrosis in mice with unilateral ureteral obstruction.  

PubMed

Renal fibrosis plays an important role in the onset and progression of chronic kidney diseases (CKD). Although several mechanisms underlying renal fibrosis and candidate drugs for its treatment have been identified, the effect of iron chelator on renal fibrosis remains unclear. In the present study, we examined the effect of an iron chelator, deferoxamine (DFO), on renal fibrosis in mice with surgically induced unilateral ureter obstruction (UUO). Mice were divided into 4 groups: UUO with vehicle, UUO with DFO, sham with vehicle, and sham with DFO. One week after surgery, augmented renal tubulointerstitial fibrosis and the expression of collagen I, III, and IV increased in mice with UUO; these changes were suppressed by DFO treatment. Similarly, UUO-induced macrophage infiltration of renal interstitial tubules was reduced in UUO mice treated with DFO. UUO-induced expression of inflammatory cytokines and extracellular matrix proteins was abrogated by DFO treatment. DFO inhibited the activation of the transforming growth factor-?1 (TGF-?1)-Smad3 pathway in UUO mice. UUO-induced NADPH oxidase activity and p22(phox) expression were attenuated by DFO. In the kidneys of UUO mice, divalent metal transporter 1, ferroportin, and ferritin expression was higher and transferrin receptor expression was lower than in sham-operated mice. Increased renal iron content was observed in UUO mice, which was reduced by DFO treatment. These results suggest that iron reduction by DFO prevents renal tubulointerstitial fibrosis by regulating TGF-?-Smad signaling, oxidative stress, and inflammatory responses. PMID:24586712

Ikeda, Yasumasa; Ozono, Iori; Tajima, Soichiro; Imao, Mizuki; Horinouchi, Yuya; Izawa-Ishizawa, Yuki; Kihira, Yoshitaka; Miyamoto, Licht; Ishizawa, Keisuke; Tsuchiya, Koichiro; Tamaki, Toshiaki

2014-01-01

282

Craniofacial morphology in unilateral hemifacial microsomia.  

PubMed

Hemifacial microsomia (HFM) is a complex three-dimensional congenital condition that is characterized by mandibular hypoplasia and unilateral or bilateral microtia; although, other facial structures may be affected. Little is known about craniofacial growth and morphology in patients with HFM; therefore, we examined 75 HFM patients by means of a cephalometric analysis in a longitudinal study on serial lateral cephalograms. We hypothesized that the growth of several facial structures on both sides of HFM patients would be different compared to Dutch controls. We determined patients with HFM had more retruded mandibles and maxillae and a more vertical morphology compared to the reference population. In addition, there was a more retruded and vertical pattern on the affected side compared to the unaffected side and in patients with a severe condition compared to those with a mild condition. 'Mild' HFM patients were more similar to the Dutch reference population than the 'severe' HFM patients. Individual HFM growth curves showed very high inter-variability, further strengthening the need for individualized treatment plans that consider all three dimensions and the severity of the condition. PMID:23201060

Ongkosuwito, E M; van Neck, J W; Wattel, E; van Adrichem, L N; Kuijpers-Jagtman, A M

2013-12-01

283

Effects of Unilateral Clefts on Brain Structure  

PubMed Central

Objective To evaluate potential abnormalities in brain structure of children and adolescents with unilateral clefts. Design Case-control study. Setting Tertiary care center. Participants Boys aged 7 to 17 years with right (n=14) and left (n=19) clefts were compared with healthy age-matched boys (n=57). Main Exposures Structural brain measures were obtained using magnetic resonance imaging. Outcome Measure It was explored whether laterality of clefts had a significant effect on brain structure. To this end, volumes of tissue types and various brain regions were evaluated. Results Total white matter was significantly lower in boys with right clefts compared with boys with left clefts and healthy boys. Gross regional analyses demonstrated that reductions in white matter were evident in both the cerebellum and the cerebrum in boys with right clefts. Furthermore, within the cerebrum, white matter volumes were particularly low in the frontal lobes and the occipital lobes. Conclusions These preliminary results suggest that right clefts may be associated with more abnormalities in brain structure. More generally, laterality of a birth defect may have a significant effect on a developing organism. PMID:20679168

van der Plas, Ellen; Conrad, Amy; Canady, John; Richman, Lynn; Nopoulos, Peg

2013-01-01

284

Influence of unilateral weight on bilateral cyclograms  

NASA Astrophysics Data System (ADS)

The paper presents the results of gait parameters as a function of unilateral weight. The object of the research was a woman walking on a stationary surface and carrying in his hand weights from 0 to 15 kg. Her movement was recorded by 6 cameras recording the location of 34 markers placed at appropriate points in the body. 3D reconstruction was performed for each of the reflecting markers. Tested signals were changes in the value the joint angles of ankle, knee and hip. On the basis of about 6 cycles of movement of each load, a model for the average gait cycle was developed. The result of the experiments are graphs of changes the joint angles as a function of time, bilateral cyclograms, synchronized bilateral cyclograms and regression lines. The conclusion of the study is to determine how one-sided load affects gait asymmetry. Simple and easy to interpret method of presentation of results were also shown. Studies were conducted using VICON system.

Pellicer Costa, Juan José; Dusza, Jacek J.

2014-11-01

285

Non-intubated thoracic surgery—A survey from the European Society of Thoracic Surgeons  

PubMed Central

Background A survey amongst the European Society of Thoracic Surgeons (ESTS) members has been performed to investigate the currents trends, rates of adoption as well as potential for future expansion of non-intubated thoracic surgery (NITS) performed under spontaneous ventilation. Methods A 14-question-based questionnaire has been e-mailed to ESTS members. To facilitate the completion of the questionnaire, questions entailed either quantitative or multiple-choice answers. Investigated issues included previous experience with NITS and number of procedures performed, preferred types of anesthesia protocols (i.e., thoracic epidural anesthesia, intercostal or paravertebral blocks, laryngeal mask, use of additional sedation), type of procedures, ideal candidates for NITS, main advantages and technical disadvantages. Non-univocal answer to multiple-choice questions was permitted. Results Out of 105 responders, 62 reported an experience with NITS. The preferred types of anesthesia were intercostal blocks with (59%) or without (50%) sedation, followed by laryngeal mask with sedation (43%) and thoracic epidural anesthesia with sedation (20%). The most frequently performed procedures included thoracoscopic management of recurrent pleural effusion (98%), pleural decortication for empyema thoracis and lung biopsy for interstitial lung disease (26% each); pericardial window and mediastinal biopsy (20% each). More complex procedures such as lobectomy, lung volume reduction surgery and thymectomy have been performed by a minority of responders (2% each). Poor-risk patients due to co-morbidities (70%) and patients with poor pulmonary function (43%) were considered the ideal candidates. Main advantages included faster, recovery (67%), reduced morbidity (59%) and shorter hospital stay with decreased costs (43% each). Reported technical disadvantages included coughing (59%) and poor maneuverability due to diaphragmatic and lung movements (56%). Overall, 69% of responders indicated that NITS procedures will be likely to increase in the near future. Conclusions Results of this survey, suggest that NITS is already quite widely adopted by ESTS members to perform simple thoracoscopic procedures. A future expanded adoption of this strategy is also hypothesized.

Sorge, Roberto; Akopov, Andrej; Congregado, Miguel; Grodzki, Tomasz

2015-01-01

286

Transperitoneal laparoscopic heminephrectomy in duplex kidneys: a one centre experience  

PubMed Central

Purpose: The standard treatment for a duplex kidney with poorly functioning upper pole moiety is ipsilateral upper pole heminephrectomy. This procedure is usually performed by open surgery, but with recent developments in techniques of uro-laparoscopy, it can be done with it, safely. In this study we evaluated the results and safety of laparoscopic heminephrectomy in our consecutive cases. Materials and Methods: From February 2001 to May 2007 fourteen unilateral laparoscopic heminephrectomy were performed in our center. Patients' characteristics, presenting symptoms, operative time, and blood loss, early and late complications were all collected retrospectively. Using pre-operative ultrasonography, intravenous pyelography (IVP) and CT scanning, unilateral upper pole hydronephrosis was detected in all cases. By DMSA isotope scan hypofunctioning of ipsilateral moieties was detected in all cases. Results: Mean operative time was 203±80 minutes. No major intra-operative or early complications were identified. Mean hospital stay was 4.1 days. On mean follow-up of 32 months no disturbing symptoms or episodes of urinary tract infections (UTIs) were detected. Atrophic kidney was detected in one case in post-operative IVP. Conclusion: Laparoscopic heminephrectomy is a valuable minimal invasive procedure that can be performed safely in experienced hands without any important complication. Perfect renal pedicles vascular system manipulation is important for the preservation of renal function post-operatively. PMID:22355281

Abedinzadeh, Mehdi; Nouralizadeh, Akbar; Radfar, Mohammad Hadi; Moslemi, Mohammad Kazem

2012-01-01

287

Keep Your Kidneys Healthy: Catch Kidney Disease Early  

MedlinePLUS

... please review our exit disclaimer . Subscribe Keep Your Kidneys Healthy Catch Kidney Disease Early Your kidneys aren’t very big—each is about the ... other substances inside your body. Unfortunately, if your kidneys start to malfunction, you might not realize it ...

288

Respiratory Displacement of the Thoracic Aorta: Physiological Phenomenon With Potential Implications for Thoracic Endovascular Repair  

SciTech Connect

The purpose of this study was to assess the magnitude and direction of respiratory displacement of the ascending and descending thoracic aorta during breathing maneuvers. In 11 healthy nonsmokers, dynamic magnetic resonance imaging was performed in transverse orientation at the tracheal bifurcation during maximum expiration and inspiration as well as tidal breathing. The magnitude and direction of aortic displacement was determined relatively to resting respiratory position for the ascending (AA) and descending (DA) aorta. To estimate a respiratory threshold for occurrence of distinct respiratory aortic motion, the latter was related to the underlying change in anterior-posterior thorax diameter. Compound displacement between maximum expiration and inspiration was 24.3 {+-} 6.0 mm for the AA in the left anterior direction and 18.2 {+-} 5.5 mm for the DA in the right anterior direction. The mean respiratory thorax excursion during tidal breathing was 8.9 {+-} 2.8 mm. The respiratory threshold, i.e., the increase in thorax diameter necessary to result in respiratory aortic displacement, was estimated to be 15.7 mm. The data suggest that after a threshold of respiratory thorax excursion is exceeded, respiration is accompanied by significant displacement of the thoracic aorta. Although this threshold may not be reached during tidal breathing in the majority of individuals, segmental differences during forced respiration impact on aortic geometry, may result in additional extrinsic forces on the aortic wall, and may be of significance for aortic prostheses designed for thoracic endovascular aortic repair.

Weber, Tim Frederik, E-mail: tim.weber@med.uni-heidelberg.d [University Medical Center Heidelberg, Department of Diagnostic and Interventional Radiology (Germany); Tetzlaff, Ralf [German Cancer Research Center, Department of Radiology (Germany); Rengier, Fabian [University Medical Center Heidelberg, Department of Diagnostic and Interventional Radiology (Germany); Geisbuesch, Philipp [University Medical Center Heidelberg, Department of Vascular and Endovascular Surgery (Germany); Kopp-Schneider, Annette [German Cancer Research Center, Department of Biostatistics (Germany); Boeckler, Dittmar [University Medical Center Heidelberg, Department of Vascular and Endovascular Surgery (Germany); Eichinger, Monika [German Cancer Research Center, Department of Radiology (Germany); Kauczor, Hans-Ulrich [University Medical Center Heidelberg, Department of Diagnostic and Interventional Radiology (Germany); Tengg-Kobligk, Hendrik von [German Cancer Research Center, Department of Radiology (Germany)

2009-07-15

289

[Video-assisted thoracic surgery--2].  

PubMed

The study presents our experience with video-assisted thoracoscopy and video-assisted thoracoscopic surgery (VATS) at the Dept. of Thoracic and Cardiovascular Surgery at Odense University Hospital. All VATS-procedures performed in the period 1/1 1993-30/9 1994 were prospectively registered. Sixty-seven procedures were undertaken on 63 patients with a median age of 35 years (range, 13-75 years). Twenty diagnostic and 47 combined diagnostic and therapeutic procedures were performed. The indications were spontaneous pneumothorax, pleural changes, diffuse interstitial lung disease, Raynaud's disease, localized lung lesion, and abnormal chest X-ray in patients with previous extrathoracic malignancy. In patients with pneumothorax, the most frequent procedures were pleurodesis with fibrin glue sealant, wedge resection with endostapler, and pleural abrasion. In the remaining groups, the most frequent procedures were pleural biopsy, wedge resection of lung parenchyma, and thoracic sympathectomy. The median time consumption during the surgical part of the VATS-procedures was 50 minutes (15-130 min.), and median hospitalization time after VATS was three days (1-10). Drains were left for more than two days after 13 procedures (22%), most often due to air leakage or persisting pneumothorax. Four VATS-procedures were converted to thoracotomy, and three had thoracotomy at a later stage during hospitalization. All thoracotomies were related to preexisting disease. No major procedure-related complications occurred. A diagnosis was achieved in every case where VATS was aimed at being purely diagnostic. Two patients had sympathectomy with good results. We conclude that VATS seems of advantage for diagnosis and therapy in many cases of benign intrathoracic disease. In addition, a histological diagnosis can be achieved and operability assessed in many cases of intrathoracic malignancy.(ABSTRACT TRUNCATED AT 250 WORDS) PMID:7652992

Kruse-Andersen, S; Ladegaard, L; Pedersen, J J; Andersen, K B

1995-07-17

290

Robotic thoracic surgery: The state of the art  

PubMed Central

Minimally invasive thoracic surgery has come a long way. It has rapidly progressed to complex procedures such as lobectomy, pneumonectomy, esophagectomy, and resection of mediastinal tumors. Video-assisted thoracic surgery (VATS) offered perceptible benefits over thoracotomy in terms of less postoperative pain and narcotic utilization, shorter ICU and hospital stay, decreased incidence of postoperative complications combined with quicker return to work, and better cosmesis. However, despite its obvious advantages, the General Thoracic Surgical Community has been relatively slow in adapting VATS more widely. The introduction of da Vinci surgical system has helped overcome certain inherent limitations of VATS such as two-dimensional (2D) vision and counter intuitive movement using long rigid instruments allowing thoracic surgeons to perform a plethora of minimally invasive thoracic procedures more efficiently. Although the cumulative experience worldwide is still limited and evolving, Robotic Thoracic Surgery is an evolution over VATS. There is however a lot of concern among established high-volume VATS centers regarding the superiority of the robotic technique. We have over 7 years experience and believe that any new technology designed to make minimal invasive surgery easier and more comfortable for the surgeon is most likely to have better and safer outcomes in the long run. Our only concern is its cost effectiveness and we believe that if the cost factor is removed more and more surgeons will use the technology and it will increase the spectrum and the reach of minimally invasive thoracic surgery. This article reviews worldwide experience with robotic thoracic surgery and addresses the potential benefits and limitations of using the robotic platform for the performance of thoracic surgical procedures. PMID:25598601

Kumar, Arvind; Asaf, Belal Bin

2015-01-01

291

Complications associated with thoracic pedicle screws in spinal deformity  

PubMed Central

Thoracic pedicle screws have superior anchoring strength compared with other available fixation techniques. However, these are not universally accepted in many developing countries because of the concerns regarding safety and complications. In addition, there is evidence that pedicle morphology is unique in Chinese patients. The goal of this study was to analyze the complications seen at our institution, while using thoracic pedicle screws for the treatment of thoracic deformity, and to determine the safety of our techniques for the treatment of thoracic deformity in a Chinese population. From 1998 to 2005, there were 208 thoracic deformity patients treated at our institution, 70 of whom were male and 138 were female. Their age ranged from 11 to 55 years (mean of 14.9 years). All of them underwent corrective deformity surgery using posterior pedicle screw systems and follow-up was available for at least 3 years. Etiologic diagnoses included adolescent idiopathic scoliosis in 119 patients, congenital kyphoscoliosis in 38, adult scoliosis in 37 and undetermined in 14. Screw positions were evaluated using intraoperative and postoperative radiographs and a CT scan was performed when a concern for screw malposition was present. All radiographic evaluations were carried out in a double-blinded fashion. A total of 1,123 thoracic pedicle screws were inserted (5.4 thoracic screws/patient). The deformity correction rate was 81, 65 and 62% for idiopathic, congenital and adult scoliosis patients, respectively. The overall complication rate was 16.5% at the final follow-up. Complication rates directly and indirectly related to pedicle screws were 7.2 and 9.3%, respectively. There were no significant screw-related neurologic or visceral complications that adversely affected long-term results. The complications seen with thoracic pedicle screws in a Chinese population were similar to other populations and could be utilized safely for the treatment of thoracic deformity in this population. PMID:20237943

Li, Gang; Lv, Guohua; Passias, Peter; Kozanek, Michal; Metkar, Umesh S.; Liu, Zhongjun; Wood, Kirkham B.; Rehak, Lubos

2010-01-01

292

Pharmacological and genetic depletion of fibrinogen protects from kidney fibrosis.  

PubMed

Fibrinogen (Fg) has been implicated in the pathogenesis of several fibrotic disorders by acting as a profibrotic ligand for a variety of cellular surface receptors and by modulating the provisional fibrin matrix formed after injury. We demonstrated increased renal Fg expression after unilateral ureteral obstruction and folic acid (FA) nephropathy in mice, respectively. Urinary Fg excretion was also increased in FA nephropathy. Using in vitro and in vivo approaches, our results suggested that IL-6 mediates STAT3 activation in kidney fibrosis and that phosphorylated (p)STAT3 binds to Fg?, Fg?, and Fg? promoters in the kidney to regulate their transcription. Genetically modified Fg heterozygous mice (?75% of normal plasma Fg levels) exhibited only 3% kidney interstitial fibrosis and tubular atrophy after FA nephropathy compared with 24% for wild-type mice. Fibrinogenolysis through Ancrod administration after FA reduced interstitial fibrosis more than threefold compared with vehicle-treated control mice. Mechanistically, we show that Fg acts synergistically with transforming growth factor (TGF)-?1 to induce fibroblast proliferation and activates TGF-?1/pSMAD2 signaling. This study offers increased understanding of Fg expression and molecular interactions with TGF-?1 in the progression to kidney fibrosis and, importantly, indicates that fibrinogenolytics like Ancrod present a treatment opportunity for a yet intractable disease. PMID:25007874

Craciun, Florin L; Ajay, Amrendra K; Hoffmann, Dana; Saikumar, Janani; Fabian, Steven L; Bijol, Vanesa; Humphreys, Benjamin D; Vaidya, Vishal S

2014-08-15

293

Laterality of nephrocalcinosis in kidney stone formers with severe hypocitraturia  

PubMed Central

OBJECTIVE To examine the hypothesis that the distribution of nephrocalcinosis in patients with severe hypocitraturia should be symmetric. PATIENTS AND METHODS Patients with profound hypocitraturia defined as a 24-h urine citrate <50 mg at the time of initial presentation were identified from the metabolic stone clinic database at our academic medical center. Two independent blinded reviewers evaluated all of the abdominal radiographs for the segmental distribution of macroscopic nephrocalcinosis. RESULTS A total of 44 patients met study criteria, with an equal distribution of males and females and a mean age of 55.4 ± 13.7 years. Mean urinary citrate was 28 ± 11 mg/day. Nephrocalcinosis was present in at least one renal segment in 22 patients (50%). Of the 22 patients with nephrocalcinosis, 9 patients (41%) had unilateral nephrocalcinosis and 13 patients (59%) had bilateral nephrocalcinosis. Of the 35 kidneys with nephrocalcinosis, 14 kidneys (40%) had nephrocalcinosis in only one renal segment, 13 kidneys (37%) had nephrocalcinosis in two segments and eight kidneys (23%) had nephrocalcinosis involving all three segments. CONCLUSIONS Despite the systemic nature of severe hypocitraturia, nephrocalcinosis is frequently asymmetric and focal in nature. This suggests that local factors intrinsic to the renal medullary interstitium, such as vascular injury, must play a role in the formation of nephrocalcinosis. Further study to elucidate these intrinsic local factors may further improve the treatment and prevention of urinary stone disease. PMID:20590541

Le, Jesse D.; Eisner, Brian H.; Tseng, Timothy Y.; Chi, Thomas; Stoller, Marshall L.

2014-01-01

294

Vasohibin-1 deficiency enhances renal fibrosis and inflammation after unilateral ureteral obstruction.  

PubMed

Tubulointerstitial injuries are known to predict the deterioration of renal function in chronic kidney disease (CKD). We recently reported the protective role of Vasohibin-1(VASH-1), a negative feedback regulator of angiogenesis, in diabetic nephropathy, but its impact on tubulointerstitial injuries remains to be elucidated. In the present study, we evaluated the role of endogenous VASH-1 in regulating the tubulointerstitial alterations induced by unilateral ureteral obstruction (UUO), and assessed its role on fibrogenesis and the activation of Smad3 signaling in renal fibroblasts. UUO was induced in female Vasohibin-1 heterozygous knockout mice (VASH-1(+/-)) or wild-type (WT) (VASH-1(+/+)) littermates. Mice were sacrificed on Day 7 after left ureter ligation, and the kidney tissue was obtained. Interstitial fibrosis, the accumulation of type I and type III collagen and monocytes/macrophages infiltration in the obstructed kidneys (OBK) were significantly exacerbated in VASH-1(+/-) mice compared with WT mice (Day 7). The increases in the renal levels of TGF-?1, pSmad3, NF-?B pp65, CCL2 mRNA, and the number of interstitial fibroblast-specific protein-1 (FSP-1)(+) fibroblasts in the OBK were significantly aggravated in VASH-1(+/-) mice. In addition, treatment with VASH-1 siRNA enhanced the TGF-?1-induced phosphorylation of Smad3, the transcriptional activation of the Smad3 pathway and the production of type I/type III collagen in fibroblasts, in vitro. Taken together, our findings demonstrate a protective role for endogenous VASH-1 on tubulointerstitial alterations via its regulation of inflammation and fibrosis and also show the direct anti-fibrotic effects of VASH-1 on renal fibroblasts through its modulation of TGF-?1 signaling. PMID:24973329

Watatani, Hiroyuki; Maeshima, Yohei; Hinamoto, Norikazu; Yamasaki, Hiroko; Ujike, Haruyo; Tanabe, Katsuyuki; Sugiyama, Hitoshi; Otsuka, Fumio; Sato, Yasufumi; Makino, Hirofumi

2014-06-01

295

Use of ultrasound to assess renal reperfusion and P-selectin expression following unilateral renal ischemia  

PubMed Central

Renal ischemia-reperfusion injury is a major cause of acute kidney injury that carries a high mortality rate and increases the risk of later development of hypertension and chronic kidney disease. Although mouse models have contributed much to our understanding of the mechanisms involved, studying aspects of the injury process in vivo remains technically challenging. This study validates the use of noninvasive ultrasound imaging to assess both renal perfusion and vascular adhesion molecule expression following 1-h unilateral renal ischemia in male and female mice. Pulsed-wave Doppler measurements of renal arterial blood velocity revealed renal perfusion recoveries of 56 ± 9% in male and 69 ± 10% in female mice 1 h after the commencing of reperfusion, which is similar to what we have previously published using conventional invasive methodology. At 24 h postischemia, renal perfusion was 40 ± 8% in male and 46 ± 7% in female mice, representing a further significant reduction of perfusion (PTime < 0.001). Using ultrasound imaging of a P-selectin-targeted contrast agent, a significant increase in vascular P-selectin protein expression was observed after 1-h reperfusion in the cortex of the postischemic compared with contralateral kidney in both male and female mice (18 ± 5 vs. 3 ± 3 intensity units in male and 30 ± 6 vs. 0 ± 4 in female mice, PIschemia < 0.01). An approximately sixfold increase in P-selectin mRNA was observed ex vivo in the renal vasculature of male and female mice at this time point (P < 0.01). In conclusion, ultrasound represents an effective and noninvasive method for the measurement of both renal perfusion and vascular adhesion molecule expression in mice. PMID:22933301

Boesen, Erika I.; Crislip, G. Ryan

2012-01-01

296

Thoracic Endometriosis Syndrome: Case Report and Review of the Literature  

PubMed Central

Thoracic endometriosis syndrome is the presence of endometrial tissue in or around the lung. Thoracic endometriosis syndrome consists of four distinct clinical entities: catamenial pneumothorax, catamenial hemothorax, hemoptysis, and pulmonary nodules. Thoracic endometriosis syndrome is a rare and complex condition, and diagnosis is often delayed or missed by clinicians, which can result in recurrent hospitalizations and other complications. Current treatments include hormone therapy and, where warranted, surgical intervention. We report the case of a 48-year-old woman with endometriosis causing bowel obstruction and concurrent catamenial pneumothorax. PMID:25102519

Azizad-Pinto, Parisa; Clarke, David

2014-01-01

297

Trans-arterial Onyx Embolization of a Functional Thoracic Paraganglioma  

PubMed Central

Paragangliomas are rare tumors of the endocrine system. They are highly vascular and in some cases hormonally active, making their management challenging. Although there is strong evidence of the safety and effectiveness of preoperative embolization in the management of spinal tumors, only five cases have been reported in the setting of thoracic paragangliomas. We present the case of a 19-year-old man with a large, primary, functional, malignant paraganglioma of the thoracic spine causing a vertebral fracture and spinal cord compression. To our knowledge this is the first report of preoperative trans-arterial balloon augmented Onyx embolization of a thoracic paraganglioma. PMID:25763296

Chacón-Quesada, Tatiana; Maud, Alberto; Ramos-Duran, Luis; Torabi, Alireza; Fitzgerald, Tamara; Akle, Nassim; Cruz Flores, Salvador; Trier, Todd

2015-01-01

298

Impact of unilateral denervation on transdiaphragmatic pressure.  

PubMed

The diaphragm muscle (DIAm) has a large reserve capacity for force generation such that in rats, the transdiaphragmatic pressure (Pdi) generated during ventilatory behaviors is less than 50% of maximal Pdi (Pdimax) elicited by bilateral phrenic nerve stimulation. Accordingly, we hypothesized that following unilateral denervation (DNV), the ability of the contralateral DIAm to generate sufficient Pdi to accomplish ventilatory behaviors will not be compromised and normal ventilation (as determined by arterial blood gas measurements) will not be impacted, although neural drive to the DIAm increases. In contrast, we hypothesized that higher force, non-ventilatory behaviors requiring Pdi generation greater than 50% of Pdimax will be compromised following DIAm hemiparalysis, i.e., increased neural drive cannot fully compensate for lack of force generating capacity. Pdi generated during ventilatory behaviors (eupnea and hypoxia (10% O2)-hypercapnia (5% CO2)) did not change after DNV and arterial blood gases were unaffected by DNV. However, neural drive to the contralateral DIAm, assessed by the rate of rise of root mean squared (RMS) EMG at 75ms after onset of inspiratory activity (RMS75), increased after DNV (p<0.05). In contrast, Pdi generated during higher force, non-ventilatory behaviors was significantly reduced after DNV (p<0.01), while RMS75 was unchanged. These findings support our hypothesis that only non-ventilatory behaviors requiring Pdi generation greater than 50% of Pdimax are impacted after DNV. Clinically, these results indicate that an evaluation of DIAm weakness requires examination of Pdi across multiple motor behaviors, not just ventilation. PMID:25641347

Gill, Luther C; Mantilla, Carlos B; Sieck, Gary C

2015-05-01

299

Postural Compensation for Unilateral Vestibular Loss  

PubMed Central

Postural control of upright stance was investigated in well-compensated, unilateral vestibular loss (UVL) subjects compared to age-matched control subjects. The goal was to determine how sensory weighting for postural control in UVL subjects differed from control subjects, and how sensory weighting related to UVL subjects’ functional compensation, as assessed by standardized balance and dizziness questionnaires. Postural control mechanisms were identified using a model-based interpretation of medial–lateral center-of-mass body-sway evoked by support-surface rotational stimuli during eyes-closed stance. The surface-tilt stimuli consisted of continuous pseudorandom rotations presented at four different amplitudes. Parameters of a feedback control model were obtained that accounted for each subject’s sway response to the surface-tilt stimuli. Sensory weighting factors quantified the relative contributions to stance control of vestibular sensory information, signaling body-sway relative to earth-vertical, and proprioceptive information, signaling body-sway relative to the surface. Results showed that UVL subjects made significantly greater use of proprioceptive, and therefore less use of vestibular, orientation information on all tests. There was relatively little overlap in the distributions of sensory weights measured in UVL and control subjects, although UVL subjects varied widely in the amount they could use their remaining vestibular function. Increased reliance on proprioceptive information by UVL subjects was associated with their balance being more disturbed by the surface-tilt perturbations than control subjects, thus indicating a deficiency of balance control even in well-compensated UVL subjects. Furthermore, there was some tendency for UVL subjects who were less able to utilize remaining vestibular information to also indicate worse functional compensation on questionnaires. PMID:21922014

Peterka, Robert J.; Statler, Kennyn D.; Wrisley, Diane M.; Horak, Fay B.

2011-01-01

300

Postural compensation for unilateral vestibular loss.  

PubMed

Postural control of upright stance was investigated in well-compensated, unilateral vestibular loss (UVL) subjects compared to age-matched control subjects. The goal was to determine how sensory weighting for postural control in UVL subjects differed from control subjects, and how sensory weighting related to UVL subjects' functional compensation, as assessed by standardized balance and dizziness questionnaires. Postural control mechanisms were identified using a model-based interpretation of medial-lateral center-of-mass body-sway evoked by support-surface rotational stimuli during eyes-closed stance. The surface-tilt stimuli consisted of continuous pseudorandom rotations presented at four different amplitudes. Parameters of a feedback control model were obtained that accounted for each subject's sway response to the surface-tilt stimuli. Sensory weighting factors quantified the relative contributions to stance control of vestibular sensory information, signaling body-sway relative to earth-vertical, and proprioceptive information, signaling body-sway relative to the surface. Results showed that UVL subjects made significantly greater use of proprioceptive, and therefore less use of vestibular, orientation information on all tests. There was relatively little overlap in the distributions of sensory weights measured in UVL and control subjects, although UVL subjects varied widely in the amount they could use their remaining vestibular function. Increased reliance on proprioceptive information by UVL subjects was associated with their balance being more disturbed by the surface-tilt perturbations than control subjects, thus indicating a deficiency of balance control even in well-compensated UVL subjects. Furthermore, there was some tendency for UVL subjects who were less able to utilize remaining vestibular information to also indicate worse functional compensation on questionnaires. PMID:21922014

Peterka, Robert J; Statler, Kennyn D; Wrisley, Diane M; Horak, Fay B

2011-01-01

301

The impacts of Unilateral Stratospheric Geoengineering  

NASA Astrophysics Data System (ADS)

Stratospheric geoengineering proposals have been suggested on the premise that the cooling impacts of volcanic eruptions could be deliberately mimicked to offset the impacts of increased greenhouse gas concentrations in the future by counterbalance global warming. Here, we examine both the impacts of hemispherically asymmetric volcanoes in the observational record and the impact of prolonged deliberate injection of stratospheric aerosol into either the northern or southern hemisphere stratosphere or into both hemispheres equally to assess the impacts on Sahelian rainfall and agriculture (Haywood et al., 2013). While the frequency of volcanic eruptions during the past 100 years is too sparse for definitive attribution, there is a suggestion that volcanic eruptions that preferentially load the northern hemisphere are the harbinger of Sahelian drought. Simulations are then performed with the HadGEM2 couple atmospheric-ocean model to assess the impacts of these volcanic eruptions and deliberate unilateral stratospheric geoengineering. Figure 1 shows the impacts of the geoengineering simulations which show that stratospheric injection into the northern hemisphere induces a severe and prolonged Sahelian drought with undoubted detrimental consequences for the local population. Conversely injection into the southern hemisphere causes a significant greening of the Sahel with vegetation productivity enhanced by over 100%. On the face of it, this suggests potential advocacy of injection into the southern hemisphere: we will investigate potential other side-effects from such a strategy...... Haywood, J.M., A. Jones, N. Bellouin, and D.B. Stephenson, Asymmetric forcing from stratospheric aerosols impacts Sahelian drought, Nature Climate Change, Vol 3, No 7, 660-665, doi: 10.1038/NCLIMATE1857, 2013.

Jones, A.; Haywood, J. M.; Bellouin, N.; Stephenson, D.

2013-12-01

302

Unilateral carpal tunnel syndrome caused by an occult palmar lipoma.  

PubMed

Carpal tunnel syndrome usually presents bilaterally and space-occupying lesions should be suspected in patients with unilateral symptoms, especially with a long history and when the symptomatic hand shows severe neurophysiologic impairment, while the contralateral hand is neurophysiologically intact. Approximately half of patients with unilateral symptoms have positive electrodiagnostic test results in the asymptomatic, contralateral hand. Space-occupying lesions are known to cause carpal tunnel syndrome and the incidence of space-occupying lesions in unilateral carpal tunnel syndrome is higher than that of bilateral carpal tunnel syndrome. It is easy to detect a mass when it is palpable, but occult lesions may be overlooked easily. Whenever a patient presents with unilateral symptoms and unilateral neurophysiologic impairment, the possibility of a space-occupying lesion compressing the median nerve should be kept in mind in the differential diagnosis. This article presents 2 cases of patients with occult deep palmar lipomas compressing the median nerve and causing unilateral symptoms of carpal tunnel syndrome. We stress the importance of imaging studies in patients with unilateral symptoms that are usually not used in carpal tunnel syndrome. While both patients' symptomatic hands showed severe neurophysiologic impairment, the contralateral hands were totally intact, which is contradictory with a long history. The reported patients were evaluated and magnetic resonance images revealed intra-tunnel lesions. Although lipomas are the most common soft tissue tumor in the body, <5% of the benign tumors of the hand are lipomas. Since the thick palmar fascia is strong, a deep lipoma may not be recognized although nerve compression symptoms may be gross. PMID:19824610

Bagatur, A Erdem; Yalcinkaya, Merter

2009-10-01

303

Kidney cancer...211 Chapter 19  

E-print Network

NICR/NCRI Kidney cancer...211 Chapter 19: Kidney cancer (C64-C66; C68) KEY FINDINGS - INCIDENCE with kidney cancer in 1994-2004. - NORTH/SOUTH COMPARISONS o Incidence rates did not differ significantly Northern Ireland and Republic of Ireland during 2000-2004. o The number of people living with kidney cancer

Paxton, Anthony T.

304

Systems biology of kidney diseases  

Microsoft Academic Search

Kidney diseases manifest in progressive loss of renal function, which ultimately leads to complete kidney failure. The mechanisms underlying the origins and progression of kidney diseases are not fully understood. Multiple factors involved in the pathogenesis of kidney diseases have made the traditional candidate gene approach of limited value toward full understanding of the molecular mechanisms of these diseases. A

John Cijiang He; Peter Y Chuang; Avi Ma'Ayan; Ravi Iyengar

2012-01-01

305

10 Symptoms of Kidney Disease  

MedlinePLUS

10 Symptoms of Kidney Disease Many people who have chronic kidney disease don't know it because the early signs can be very subtle. ... the same side as the affected kidney. Polycystic kidney disease (PKD) , which causes large, fluid-filled cysts on ...

306

JAMA Patient Page: Kidney Transplantation  

MedlinePLUS

... be required before full kidney function is restored. Kidney transplantation is a major operation usually requiring general anesthesia. An incision is made and the donor kidney is placed in the lower abdomen. The recipient’s own poorly functioning kidneys are usually not removed. ...

307

Anemia in Chronic Kidney Disease  

MedlinePLUS

... Topics and Titles : Anemia in Chronic Kidney Disease Anemia in Chronic Kidney Disease On this page: What is anemia? How is ... carry oxygen throughout the body. [ Top ] What causes anemia in chronic kidney disease? When kidneys are diseased or damaged, they do ...

308

Effects of unilateral decompressive craniectomy on patients with unilateral acute post-traumatic brain swelling after severe traumatic brain injury  

PubMed Central

Introduction Acute post-traumatic brain swelling (BS) is one of the pathological forms that need emergent treatment following traumatic brain injury. There is controversy about the effects of craniotomy on acute post-traumatic BS. The aim of the present clinical study was to assess the efficacy of unilateral decompressive craniectomy (DC) or unilateral routine temporoparietal craniectomy on patients with unilateral acute post-traumatic BS. Methods Seventy-four patients of unilateral acute post-traumatic BS with midline shifting more than 5 mm were divided randomly into two groups: unilateral DC group (n = 37) and unilateral routine temporoparietal craniectomy group (control group, n = 37). The vital signs, the intracranial pressure (ICP), the Glasgow outcome scale (GOS), the mortality rate and the complications were prospectively analysed. Results The mean ICP values of patients in the unilateral DC group at hour 24, hour 48, hour 72 and hour 96 after injury were much lower than those of the control group (15.19 +/- 2.18 mmHg, 16.53 +/- 1.53 mmHg, 15.98 +/- 2.24 mmHg and 13.518 +/- 2.33 mmHg versus 19.95 +/- 2.24 mmHg, 18.32 +/- 1.77 mmHg, 21.05 +/- 2.23 mmHg and 17.68 +/- 1.40 mmHg, respectively). The mortality rates at 1 month after treatment were 27% in the unilateral DC group and 57% in the control group (p = 0.010). Good neurological outcome (GOS Score of 4 to 5) rates 1 year after injury for the groups were 56.8% and 32.4%, respectively (p = 0.035). The incidences of delayed intracranial hematoma and subdural effusion were 21.6% and 10.8% versus 5.4% and 0, respectively (p = 0.041 and 0.040). Conclusions Our data suggest that unilateral DC has superiority in lowering ICP, reducing the mortality rate and improving neurological outcomes over unilateral routine temporoparietal craniectomy. However, it increases the incidence of delayed intracranial hematomas and subdural effusion, some of which need secondary surgical intervention. These results provide information important for further large and multicenter clinical trials on the effects of DC in patients with acute post-traumatic BS. Trial registration ISRCTN14110527 PMID:19930556

2009-01-01

309

Kidney and Ureteral Stones  

MedlinePLUS

... formed by a repeating, three-dimensional pattern of atoms, ions or molecules. CT scan: Also known as ... inserting instruments into the body. ions: Electrically charged atoms. kidney: One of two bean-shaped organs that ...

310

Kidney Disease and Diabetes  

MedlinePLUS

... and phosphate. When the body functions normally, the kidneys are able to remove these waste products. Other effects of chronic renal failure include anemia, bone disease, acidosis, and salt and fluid retention. Most patients ...

311

Acquired Cystic Kidney Disease  

MedlinePLUS

... years develop ACKD. 1, 2 1 Fick-Brosnahan GM. Polycystic and acquired cystic kidney disease. In: Greenberg ... for questions about any medications, contact the U.S. Food and Drug Administration toll-free at 1–888– ...

312

Kidney Transplants (Adults)  

MedlinePLUS

... doctor services. You pay various amounts for transplant facility charges. You pay nothing for a living donor for a kidney transplant. You pay nothing for Medicare-approved laboratory tests. Note To find out how much your specific ...

313

Polyamines in Kidney Biology  

Microsoft Academic Search

The function of the kidney is largely considered filtration of the plasma compartment and removal of waste liquids and metabolic\\u000a end products. Of equal importance is the conservation of liquids and solutes by reabsorption that is required to maintain\\u000a life. The kidney functions to precisely regulate the body’s fluid compartment, maintain electrolytic and acid balance of the\\u000a plasma, and secrete

Joseph Satriano

314

Kidney cell electrophoresis  

NASA Technical Reports Server (NTRS)

Tasks were undertaken in support of two objectives. They are: (1) to carry out electrophoresis experiments on cells in microgravity; and (2) assess the feasibility of using purified kidney cells from embryonic kidney cultures as a source of important cell products. Investigations were carried out in the following areas: (1) ground based electrophoresis technology; (2) cell culture technology; (3) electrophoresis of cells; (4) urokinase assay research; (5) zero-g electrophoresis; and (6) flow cytometry.

Todd, P. W.

1985-01-01

315

The kidney exchange game  

Microsoft Academic Search

Abstract. The most efiective treatment for kidney failure that is currently known,is transplantation. As the number of cadaveric donors is not su?cient and kidneys from living donors are often not suitable for immunological reasons, there are attempts to organize exchanges between patient-donor pairs. In this paper we model this situation as a cooperative game and propose some algorithms for flnding

Katarna Cechlarova; Tamas Fleiner; David Manlove

316

The medieval kidney.  

PubMed

This article surveys the various perceptions of the kidney and its pathologies by encyclopedists, preachers, natural philosophers, surgeons and academic physicians around 1300. It focuses on the medical works of Arnau de Vilanova (d. 1311) and shows the medical discourse about the kidney in all its complexity. It draws attention to the incorporation of the medical nephrological debate into the scholastic frame, and to the close links between nephrology and astrology as well as alchemy. PMID:12097733

Ziegler, Joseph

2002-07-01

317

Kidney Disease of Diabetes  

NSDL National Science Digital Library

The National Kidney and Urologic Diseases Information Clearinghouse (NKUDIC) is a service provided by a related department of the National Institutes of Health (NIH). Visitors will find that the NKUDIC website has a special page on Kidney Disease of Diabetes which includes articles on the homepage about "The Course of Kidney Disease", "Preventing and Slowing Kidney Disease", and "Good Care Makes a Difference". On the left side of the homepage visitors will find some very interesting research timelines by the NIH, titled "Yesterday, Today and Tomorrow". There is a timeline for "Chronic Kidney Disease and Kidney Failure", "Diabetes, Type 1", and "Diabetes, Type 2". The "Yesterday" section explain to visitors the past methods of treating the disease, as well as past statistics about death and diseases caused by diabetes. The "Today" section explains how the disease is treated presently, and how statistics have improved regarding survival and occurrence of diabetes-related disease. Finally, the "Tomorrow" section highlights research studies that aim to improve the lives of diabetics, and interested visitors will find links to relevant websites.

318

Hereditary Interstitial Kidney Disease  

PubMed Central

Summary Autosomal-dominant interstitial kidney disease is characterized by slow progression of chronic kidney disease in patients with bland urinary sediment and no or low-grade proteinuria. There are at least three subtypes. Patients with mutations in the UMOD gene encoding uromodulin suffer from precocious gout in addition to chronic kidney failure. Diagnosis can be achieved through genetic analysis of the UMOD gene. Patients with mutations in the REN gene encoding renin suffer from anemia in childhood, hyperuricemia, mild hyperkalemia, and progressive kidney disease. Genetic analysis of the REN gene can be performed to diagnose affected individuals. There is a third form of inherited interstitial kidney disease for which the cause has not been found. These individuals suffer from chronic kidney disease with no other identified clinical signs. Linkage to chromosome 1 has been identified in a number of these families. Proper diagnosis is valuable not only to the affected individual but also to the entire family and can facilitate treatment, transplantation, and research efforts. PMID:20807609

Bleyer, Anthony J.; Hart, P. Suzanne; Kmoch, Stanislav

2014-01-01

319

Signaling during Kidney Development.  

PubMed

The kidney plays an essential role during excretion of metabolic waste products, maintenance of key homeostasis components such as ion concentrations and hormone levels. It influences the blood pressure, composition and volume. The kidney tubule system is composed of two distinct cell populations: the nephrons forming the filtering units and the collecting duct system derived from the ureteric bud. Nephrons are composed of glomeruli that filter the blood to the Bowman's capsule and tubular structures that reabsorb and concentrate primary urine. The collecting duct is a Wolffian duct-derived epithelial tube that concentrates and collects urine and transfers it via the renal pelvis into the bladder. The mammalian kidney function depends on the coordinated development of specific cell types within a precise architectural framework. Due to the availability of modern analysis techniques, the kidney has become a model organ defining the paradigm to study organogenesis. As kidney diseases are a problem worldwide, the understanding of mammalian kidney cells is of crucial importance to develop diagnostic tools and novel therapies. This review focuses on how the pattern of renal development is generated, how the inductive signals are regulated and what are their effects on proliferation, differentiation and morphogenesis. PMID:25867084

Krause, Mirja; Rak-Raszewska, Aleksandra; Pietilä, Ilkka; Quaggin, Susan E; Vainio, Seppo

2015-01-01

320

Type 1 angiotensin receptors on macrophages ameliorate IL-1 receptor-mediated kidney fibrosis.  

PubMed

In a wide array of kidney diseases, type 1 angiotensin (AT1) receptors are present on the immune cells that infiltrate the renal interstitium. Here, we examined the actions of AT1 receptors on macrophages in progressive renal fibrosis and found that macrophage-specific AT1 receptor deficiency exacerbates kidney fibrosis induced by unilateral ureteral obstruction (UUO). Macrophages isolated from obstructed kidneys of mice lacking AT1 receptors solely on macrophages had heightened expression of proinflammatory M1 cytokines, including IL-1. Evaluation of isolated AT1 receptor-deficient macrophages confirmed the propensity of these cells to produce exaggerated levels of M1 cytokines, which led to more severe renal epithelial cell damage via IL-1 receptor activation in coculture compared with WT macrophages. A murine kidney crosstransplantation concomitant with UUO model revealed that augmentation of renal fibrosis instigated by AT1 receptor-deficient macrophages is mediated by IL-1 receptor stimulation in the kidney. This study indicates that a key role of AT1 receptors on macrophages is to protect the kidney from fibrosis by limiting activation of IL-1 receptors in the kidney. PMID:24743144

Zhang, Jian-dong; Patel, Mehul B; Griffiths, Robert; Dolber, Paul C; Ruiz, Phillip; Sparks, Matthew A; Stegbauer, Johannes; Jin, Huixia; Gomez, Jose A; Buckley, Anne F; Lefler, William S; Chen, Daian; Crowley, Steven D

2014-05-01

321

Prolonged hyperkalemia following unilateral adrenalectomy for primary hyperaldosteronism.  

PubMed

Hypokalemia associated with aldosterone-producing adenomas (APA) are almost corrected following successful unilateral adrenalectomy. Prolonged hyperkalemia after unilateral adrenalectomy is rarely reported and may be overlooked. We describe a 62-year-old man who presented with fatigue and dizziness 2 weeks after unilateral adrenalectomy for aldosterone-producing adenomas. Physical examination showed decreased skin turgor and postural hypotension. Laboratory studies revealed hyperkalemia (6.3 mmol/l) with a low transtubular potassium gradient of 5. A relatively low plasma aldosterone concentration and high plasma renin activity in the setting of normal plasma cortisol and adrenocorticotropic hormone levels lead to a diagnosis of functional hypoaldosteronism. Fludrocortisone 0.2 mg/day for one week completely corrected his hyperkalemia which recurred after cessation of fludrocortisone. Long-term suppression of contralateral aldosterone synthesis by APA and/or chronic untreated hypokalemia may have accounted for the development of prolonged hyperkalemia after unilateral adrenalectomy. Serum potassium concentration following unilateral adrenalectomy must be meticulously monitored to avoid life-threatening hyperkalemia. PMID:20420801

Huang, W-T; Chau, T; Wu, S-T; Lin, S-H

2010-05-01

322

Clinical and surgical management of unilateral prepubertal gynecomastia  

PubMed Central

INTRODUCTION Gynecomastia is the benign proliferation of the glandular tissue in the male breast. This condition is thought to be caused by the imbalance between estrogen action relative to androgen action at the breast tissue level. Bilateral gynecomastia is frequently found in the neonatal period, early in puberty, and with increasing age. Prepubertal unilateral gynecomastia in the absence of endocrine abnormalities is extremely rare, with only a few cases in literature. PRESENTATION OF CASE We present an otherwise healthy boy of 12 years old with unilateral breast masses. No abnormalities were found on ultrasonography and on all endocrine parameters. Treatment consisted in a new “modified” Webster technique. DISCUSSION The results confirmed validity of this technique in terms of esthetic and functional results, and patient satisfaction. Atypical presentations of gynecomastia are often not recognized. The main pathophysiology of gynecomastia is alteration in the balance between the stimulatory effect of estrogen and the inhibitory effects of androgens on the development of the breast. If there is no causal treatment, surgical resection is the therapy of first choice. CONCLUSION The exact mechanism of unilateral gynecomastia formation in our case is unclear. The evaluation of unilateral gynecomastia can therefore be complex. In conclusion, the surgical treatment of unilateral gynecomastia requires an individual approach, based on an appropriate diagnostic algorithm. PMID:25437663

Ferraro, Giuseppe Andrea; De Francesco, Francesco; Romano, Tiziana; Grandone, Anna; D’Andrea, Francesco; Miraglia Del Giudice, Emanuele; Perrone, Laura; Nicoletti, Gianfranco

2014-01-01

323

The usefulness of preoperative biopsy in unilateral nasal masses.  

PubMed

Unilateral nasal masses are considered suspicious for proliferative diseases. Several tools are routinely used to investigate unilateral lesions such as imaging and nasal biopsy. This study investigated the usefulness of nasal biopsy in predicting the actual nature of unilateral lesions. Preoperative nasal biopsy pathological results were compared with the final pathology obtained during an operation. Forty-six patients with unilateral nasal masses were included in the study group. In 40 patients the final pathology was similar to the preoperative nasal biopsy. In three patients the biopsy specimen was a benign polyp and the final pathology was of an inverted papilloma in two patients and hemangiopericytoma in one patient. In two patients the biopsy specimen was suspicious for an inverted papilloma and the final pathology was a benign polyp. In one patient the biopsy specimen was chordoma and the final pathology was osteosarcoma. The total agreement was 86.9%. The kappa value was 81.2%. Preoperative nasal biopsy is important and useful in evaluating unilateral nasal masses. PMID:24684868

Segal, Nili; Gluck, Ofer; Bavnik, Yosef; Plakht, Ygal; Yakirevitch, Arkadi

2014-03-01

324

Segmental thoracic lipomatosis of nerve with nerve territory overgrowth.  

PubMed

Lipomatosis of nerve (LN), or fibrolipomatous hamartoma, is a rare condition of fibrofatty enlargement of the peripheral nerves. It is associated with bony and soft tissue overgrowth in approximately one-third to two-thirds of cases. It most commonly affects the median nerve at the carpal tunnel or digital nerves in the hands and feet. The authors describe a patient with previously diagnosed hemihypertrophy of the trunk who had a history of large thoracic lipomas resected during infancy, a thoracic hump due to adipose proliferation within the thoracic paraspinal musculature, and scoliotic deformity. She had fatty infiltration in the thoracic spinal nerves on MRI, identical to findings pathognomonic of LN at better-known sites. Enlargement of the transverse processes at those levels and thickened ribs were also found. This case appears to be directly analogous to other instances of LN with overgrowth, except that this case involved axial nerves rather than the typical appendicular nerves. PMID:24506247

Mahan, Mark A; Amrami, Kimberly K; Howe, B Matthew; Spinner, Robert J

2014-05-01

325

Vertical expandable prosthetic titanium rib for thoracic insufficiency syndrome  

Microsoft Academic Search

PurposeThe vertical expandable prosthetic titanium rib (VEPTR) thoracoplasty is a new technique devised for the treatment children with thoracic insufficiency syndrome. This study describes our initial experience with this device.

John H. T. Waldhausen; Gregory J. Redding; Kit M. Song

2007-01-01

326

[Tension pneumopericardium: a rare complication after thoracic stab wound].  

PubMed

The authors report a case involving a patient with thoracic stab wound. The patient developed tension pneumopericardium with acute cardiac tamponade. The clinical and radiological features of tension pneumopericardium and its treatment are discussed. PMID:12494808

Faroudy, M; Marzouk, N; Ababou, A; Lazreq, C; Sbihi, A

2002-11-01

327

Lymphoscintigraphic evaluation of the thoracic duct in the canine  

E-print Network

(1. ). b) A lymphangio- gxam of the same dog. Notice the dilated lymphabcs (small white arrow), thoracic lymphangiectasia (laxge arrow), and i~ized regions of contrast rostral to the heart consistent with a mediastinal lymph node (open arrow). 32... OF SCIENCE December 1990 Major Subject: Veterinary Medicine and Surgery LYMPHOSCINTIGRAPHIC EVALUATION OF THE THORACIC DUCT IN THE CANINE A Thesis by CARLOS CINTRON HODGES Approved as to style and content by: H W. Boothe (Chair of Committee) D...

Hodges, Carlos Cintron

1990-01-01

328

Twelve Contiguous Spinous Process Fracture of Cervico-Thoracic Spine  

PubMed Central

The clay-shoveler's fracture is an isolated avulsion fracture of the lower cervical or upper thoracic spinous process. Among them, multiple spinous process fractures are very rare. We present 34-year-old male patient who have multiple spinous process fractures with twelve contiguous levels of cervico-thoracic spine (from C4 to T8) after motorcycle accident. This case is multiple isolated spinous process fractures with good clinical outcome. PMID:25346773

Sohn, Moon Jun

2014-01-01

329

Double migration of a schwannoma of thoracic spine  

PubMed Central

Mobile intraspinal tumours have rarely been reported. In most cases, mobile tumours such as schwannomas or ependymomas were located in the cauda equina. Perusal of the literature revealed only two reports of mobile schwannomas in the cervical and thoracic regions. We report a case of thoracic schwannoma which migrated twice in successive operations resulting in negative exploration in the expected area. The aim of this report is to remind the surgeons about the possibility of migration of intradural-extramedullary tumour. PMID:23349180

Khan, Robert Ahmed; Rahman, Asifur; Bhandari, Paawan Bahadur; Khan, SIM Khairun Nabi

2013-01-01

330

The year in thoracic surgery: highlights from 2014.  

PubMed

The year 2014 produced several noteworthy articles that have advanced the care of thoracic surgery patients. Further knowledge has been gained regarding screening and treatment of early stage lung cancer. The use of neoadjuvant therapy for subsets of patients with esophageal cancer continues to evolve. Endobronchial therapy for emphysema is reported in a multicenter trial. The purpose of this review is to highlight the major advances in thoracic surgical disease in the year 2014. PMID:25667305

Weyant, Michael J

2015-03-01

331

Anterior thoracic posture increases thoracolumbar disc loading.  

PubMed

In the absence of external forces, the largest contributor to intervertebral disc (IVD) loads and stresses is trunk muscular activity. The relationship between trunk posture, spine geometry, extensor muscle activity, and the loads and stresses acting on the IVD is not well understood. The objective of this study was to characterize changes in thoracolumbar disc loads and extensor muscle forces following anterior translation of the thoracic spine in the upright posture. Vertebral body geometries (C2 to S1) and the location of the femoral head and acetabulum centroids were obtained by digitizing lateral, full-spine radiographs of 13 men and five women volunteers without previous history of back pain. Two standing, lateral, full-spine radiographic views were obtained for each subject: a neutral-posture lateral radiograph and a radiograph during anterior translation of the thorax relative to the pelvis (while keeping T1 aligned over T12). Extensor muscle loads, and compression and shear stresses acting on the IVDs, were calculated for each posture using a previously validated biomechanical model. Comparing vertebral centroids for the neutral posture to the anterior posture, subjects were able to anterior translate +101.5 mm+/-33.0 mm (C7-hip axis), +81.5 mm+/-39.2 mm (C7-S1) (vertebral centroid of C7 compared with a vertical line through the vertebral centroid of S1), and +58.9 mm+/-19.1 mm (T12-S1). In the anterior translated posture, disc loads and stresses were significantly increased for all levels below T9. Increases in IVD compressive loads and shear loads, and the corresponding stresses, were most marked at the L5-S1 level and L3-L4 level, respectively. The extensor muscle loads required to maintain static equilibrium in the upright posture increased from 147.2 N (mean, neutral posture) to 667.1 N (mean, translated posture) at L5-S1. Compressive loads on the anterior and posterior L5-S1 disc nearly doubled in the anterior translated posture. Anterior translation of the thorax resulted in significantly increased loads and stresses acting on the thoracolumbar spine. This posture is common in lumbar spinal disorders and could contribute to lumbar disc pathologies, progression of L5-S1 spondylolisthesis deformities, and poor outcomes after lumbar spine surgery. In conclusion, anterior trunk translation in the standing subject increases extensor muscle activity and loads and stresses acting on the intervertebral disc in the lower thoracic and lumbar regions. PMID:15168237

Harrison, Deed E; Colloca, Christopher J; Harrison, Donald D; Janik, Tadeusz J; Haas, Jason W; Keller, Tony S

2005-04-01

332

[Management of unilateral or asymmetrical lung disease (author's transl)].  

PubMed

To determine the indications of body position, continuous positive airway pressure and independent lung ventilation in unilateral lung disease, we turned 10 patients with overwhelming unilateral lung disease from supine to lateral position. All patients were breathing spontaneously with a mask, then associated with continuous airway pressure (10 cm H2O PEEP) in five cases. During these spontaneous ventilation methods, hemodynamic parameters did not change, but arterial blood oxygen tension increased and intra-pulmonary shunting decreased significantly. Final recovery was obtained in 7 cases. In the 3 others, mechanical ventilation was needed because spontaneous breathing methods were ineffective in improving blood gases. Lateral position and conventional ventilation with positive airway pressure were also ineffective. Only independent ventilation enhanced arterial blood oxygen tension. But only one patient survived. We conclude that spontaneous breathing methods are able to provide successful treatment in most of patients with unilateral lung disease. In other patients, only independent lung ventilation is effective. PMID:7036794

Bons, J; Dhainaut, J F; Lesgourgues, B; Schlemmer, B; Carli, A; Monsallier, J F

1981-01-01

333

Unilateral versus bilateral clubfoot: an analysis of severity and correlation.  

PubMed

This study compares the severity of unilateral and bilateral clubfoot, and the correlation between right and left feet of bilateral cases. Sixty-six unilateral and 75 bilateral clubfoot patients were assessed for severity using the Pirani score at an average age of 12.9 days (SD 9 days). In bilateral cases, the severity of right and left feet was highly correlated (r=0.68). The odds of being very severe were 2.6 (95% confidence interval 1.3-5.1) times higher in bilateral cases (P=0.007). Bilateral and unilateral clubfeet present with differing severity. Right and left feet from bilateral cases are highly correlated. Researchers need to address these issues during study design and analysis. PMID:24869905

Gray, Kelly; Barnes, Elizabeth; Gibbons, Paul; Little, David; Burns, Joshua

2014-09-01

334

Prepubertal unilateral gynecomastia in the absence of endocrine abnormalities  

PubMed Central

Gynecomastia is defined as the excessive development of breast tissue in males, which can occur as unilateral or bilateral. Although the overall prevalence of gynecomastia is 40%-65%, the prepubertal unilateral gynecomastia in the absence of endocrine abnormalities is unusual, with only a few case reports in literature. Idiopathic gynecomastia in prepuberty is benign but a diagnosis of exclusion. We here report two cases of healthy prepubertal boys aged 8.8 and 9.6 years old, respectively, presented with painful palpable mass in their unilateral breast. Breast tissue with glandular proliferation was confirmed on ultrasonography. Serum levels of estradiol, testosterone, and other laboratory findings were within normal range. They seem to have the prepubertal idiopathic gynecomastia but further follow-up to see their progression is needed. PMID:25346921

Kang, Min; Lee, Chan Jae; Hwang, Il Tae; Lee, Kwanseop

2014-01-01

335

Unilateral Breast Reconstruction Using Bilateral Inferior Gluteal Artery Perforator Flaps  

PubMed Central

Background: For reconstructing moderate-to-high projection breasts in nulliparous patients with insufficient abdominal tissue or prior abdominal surgeries, a unilateral inferior gluteal artery perforator (IGAP) flap is an alternative procedure. In patients with slim hips, however, unilateral gluteal tissue is insufficient and inferior gluteal crease displacement may develop postoperatively. Donor-site asymmetry is also a major disadvantage. In these circumstances, bilateral IGAP flaps provide sufficient tissue without significant gluteal deformity. Methods: We retrospectively reviewed 20 patients who underwent unilateral breast reconstruction using bilateral IGAP flaps by a single surgeon between November 2007 and December 2012. A quantitative outcome assessment was performed and compared with that of 22 unilateral IGAP flap patients operated on by the same surgeon. Results: Twenty patients underwent reconstruction with 40 IGAP flaps. Of the 40 flaps, 39 survived and 1 developed total necrosis due to repeated venous thrombosis. In 15 of 20 patients, the size of reconstructed breast was comparable to that of the contralateral breast. Final inset flap weight was 462.3 g for bilateral flaps and 244.3 g for unilateral flaps. Total operating time was 671.1 minutes (bilateral flaps) and 486.8 minutes (unilateral flaps). Conclusions: Use of bilateral IGAP flaps for breast reconstruction helps to avoid asymmetry of the inferior buttock volume and shape. Bilateral flaps provide sufficient tissue volume and allow for reconstruction of a breast comparable to the unaffected side. In patients with moderate-to-high projection breast whose abdominal tissue cannot be used for reconstruction, IGAP flaps may be a suitable alternative. PMID:25878925

Muto, Mayu; Ogawa, Marina; Shibuya, Mai; Yasumura, Kazunori; Kobayashi, Shinji; Ishikawa, Takashi; Maegawa, Jiro

2015-01-01

336

Endovascular Management of Thoracic Aortic Aneurysms  

SciTech Connect

The overall survival of patients with thoracic aortic aneurysm (TAA) has improved significantly in the past few years. Endovascular treatment, proposed as an alternative to surgery, has been considered a therapeutic innovation because of its low degree of invasiveness, which allows the treatment of even high-surgical risk patients with limited complications and mortality. A major limitation is the lack of adequate evidence regarding long-term benefit and durability because follow-up has been limited to just a few years even in the largest series. The combination of endovascular exclusion with visceral branch revascularization for the treatment of thoraco-abdominal aortic aneurysms involving the visceral aorta has also been attempted. As an alternative, endografts with branches represent a technological evolution that allows treatment of complex anatomy. Even if only small numbers of patients and short follow-up are available, this technical approach, which has with limited mortality (<10%) and paraplegia rates, to expand endovascular treatment to TAA seems feasible. With improved capability to recognize proper anatomy and select clinical candidates, the choice of endovascular stent-graft placement may offer a strategy to optimize management and improve prognosis.

Fattori, Rossella, E-mail: rossella.fattori@unibo.it; Russo, Vincenzo; Lovato, Luigi; Buttazzi, Katia; Rinaldi, Giovanni [University Hospital S. Orsola, Cardiovascular Radiology Unit, Cardio-Thoracic-Vascular Department (Italy)

2011-12-15

337

Primary osseous hemangiopericytoma in the thoracic spine.  

PubMed

Hemangiopericytoma (HPC) is a rare tumor of the central nervous system, most commonly found in the cranial cavity. HPCs in the spine are rare, and very few of them are primary osseous HPC. The aims of this study were to describe a rare case of primary osseous HPC in the thoracic spine and review the literature. A 54-year-old man presented with a 3-month history of back pain. Aneuro logical examination revealed no motor or sensory deficits. Magnetic resonance imaging (MRI) and computed tomography (CT) scan showed a tumor originating from the bone structure of the T10 vertebra with paravertebral extension, and chest CT revealed pulmonary metastases. A laminectomy, face-totomy,and subtotal resection of the tumor was performed with posterior pedicle screw system fixation followed by radiotherapy. The post-operative course was uneventful. His back pain was resolved completely after surgery. The patient survived with tumor during the 18-month follow-up period. Histopathology and immunohistologic findings were consistent with HPC. On immunohistochemistry, the tumor was positive for vimentin and CD34, partially positive for S-100, but negative for EMA, desmin, CD117, and CD1a. A literature review identified eight such cases reported between 1942 and 2013. As a conclusion, clinical manifestations of primary osseous spinal HPCs are different from intraspinal meningeal HPCs. Although showing certain variability, histopathology and immunohistochemical examinations are essential to establish the diagnosis. Surgical resection and radiotherapy are the treatment of choice. *These authors contributed equally to this work. PMID:24887400

Ren, Ke; Zhou, Xing; Wu, SuJia; Sun, Xiaoliang

2014-01-01

338

Infraclavicular subpectoral lipoma causing thoracic outlet syndrome  

PubMed Central

Introduction Thoracic outlet syndrome (TOS) includes a group of disorders caused by extrinsic compression of neurovascular structures between the 1st rib and clavicle. It usually presents as an enlarging neck mass, with shoulder or upper limb pain, weakness, paresthesias and impalpable radial pulse (Raynaud’s phenomenon). Presentation of case We report a rare case of TOS caused by an infraclavicular subpectoral lipoma that, although challenging because of limited access and proximity of vital neurovascular structures, was successfully removed through a simple transaxillary incision with an excellent esthetic result. The patients is symptom-free 6 months after surgery. Discussion Multiplicity of symptoms makes causes, diagnosis, and treatment of TOS controversial. Accurate diagnosis of TOS can be a substantial challenge in practice, because of a lack of physician awareness, overlapping of clinical features, and an absence of clearly defined diagnostic criteria. TOS may be associated with the presence of a benign subpectoral mass like lipomas, that seldom have an irregular distribution that involve neurovascular structures. Conclusion Although benign soft tissue tumors infraclavicular subpectoral lipomas may exert pressure on neurovascular surrounding structures during their progressive expansion and cause TOS. Therefore, a thorough preoperative study by radiological imaging such as MRI or neurophysiological test should always be performed in order to prevent unintentional lesions of the involved axillo-subclavicular plexus and plan correct surgical procedure. PMID:25746951

Elia, Stefano; Cerioli, Alessandra; Fiaschetti, Valeria; Granai, Alessandra Vittoria

2015-01-01

339

Thoracic intramedullary sarcoidosis mimicking an intramedullary tumor.  

PubMed

Sarcoidosis is a chronic, systemic granulomatous reticulosis of unknown origin, characterized by formation of hard tubercles and noncaseatinggranulomas. Since other infectious diseases such as berylliosis, mycobacterium and fungal infections may present with a noncaseating granulomas, histological diagnosis of sarcoidosis is made using the elimination method. Central nervous system manifestations of sarcoidosis may be present in 5-10% of the cases involving cranial nerves, leptomeninges and third ventricle respectively. Any part of the central nervous system can be affected. Involvement of spinal cord in sarcoidosis is extremely rare and presents with only 0.3-0.4% in patients with systemic sarcoidosis. Intramedullary sarcoidosis is a rare first manifestation of the disease and it can mimic an intramedullary tumor, which is often manifested with symptoms that initiate from spinal cord compression, resulting in paraparesis, sensory disorders and sphincter dysfunction. We present a case of intramedullary sarcoidosis that mimics a tumor of the thoracic spinal cord. Clinical features, neuroradiological, pathohistological findings, laboratory analysis and surgical treatment of such a rare entity are being discussed. PMID:18756925

Beros, Vili; Houra, Karlo; Rotim, Kresimir; Kovac, Damir; Cupi?, Hrvoje

2008-06-01

340

Occult Contralateral Carcinoma in Patients with Unilateral Papillary Thyroid Microcarcinoma  

Microsoft Academic Search

Background  The optimal resection extent for papillary thyroid microcarcinoma (PTMC) confined within a unilateral lobe remains controversial.\\u000a \\u000a \\u000a \\u000a Materials and Methods  We reviewed the medical records of 132 consecutive patients who underwent total thyroidectomy for the treatment of clinically\\u000a unilateral PTMC between March 2005 and March 2009. The frequency, pattern, and predictive factors for occult contralateral\\u000a carcinoma in these patients were analyzed with

Bon Seok Koo; Hyun Sil Lim; Young Chang Lim; Yeo-Hoon Yoon; Yong Min Kim; Yong Ho Park; Ki-Sang Rha

2010-01-01

341

Cold shivering activity after unilateral destruction of the vestibular apparatus  

NASA Technical Reports Server (NTRS)

The bioelectric activity of muscles (flexors and extensors of the forelimbs and hindlimbs) during cold shivering after unilateral destruction of the vestibular apparatus. It was found, that unilateral delabyrinthing produces bilateral facilitation of cold shivering in the flexor extremities more pronounced on the ipsilateral side. In the extensor muscles there was an absence of bioelectric activity both before and after delabyrinthing. Enhancement of cold shivering in the flexor extremities following intervention was evidently conditioned by removal of the inhibiting effect of the vestibulary apparatus on the function of special centers.

Kuzmina, G. I.

1980-01-01

342

Array-CGH and quantitative PCR genetic analysis in a case with bilateral hypoplasia of pulmonary arteries and lungs and simultaneous unilateral renal agenesis  

PubMed Central

We describe the clinical course and have characterised anatomically and genetically a unique case of a newborn with bilateral hypoplasia of pulmonary arteries, consecutive extremely hypoplastic lung tissue and associated unilateral renal agenesis. Intrauterine oxygenation by the placenta seemed to have allowed normotrophic body maturity but immediately after delivery, in the third trimester, progressive hypoxemia developed and the newborn succumbed to acute respiratory failure. Genetic analysis by array-based comparative genomic hybridisation and quantitative PCR revealed duplication of 1p21, which, however, might not be the disease causing aberration. This case might represent an extreme form of previously reported, rare cases with simultaneous dysorganogenesis of lungs and kidneys. PMID:20830244

Hussein, Kais; Steinemann, Doris; Scholz, Henrike; Menkhaus, Ralf; Feist, Henning; Kreipe, Hans

2010-01-01

343

Integrins in Kidney Disease  

PubMed Central

A major hallmark of chronic kidney injury is fibrosis, which is characterized by increased accumulation of extracellular matrix components that replace the damaged tissue. Normally, the synthesis and degradation of extracellular matrix components are finely regulated; however, when matrix replacement goes unchecked, there is unwanted and irreversible tissue scarring with consequent organ damage, organ failure, and, in certain cases, death. Many factors, including cell-matrix interactions, play a role in the development of renal fibrosis. Cell-matrix interactions are made possible by integrins, a family of transmembrane receptors that, upon binding to the extracellular matrix, activate intracellular signaling. Thus, they control various cell functions, including survival, proliferation, migration, and matrix homeostasis. Genetic mutations in humans and the development of animal models lacking integrins in selective parts of the kidney have improved our understanding of molecular mechanisms and pathways controlling matrix remodeling in kidney disease. Here we outline the major integrins involved in kidney disease and some of the major molecular mechanisms whereby integrins contribute to kidney fibrosis. PMID:23641054

2013-01-01

344

Unilateral cochlear ablation produces greater loss of inhibition in the contralateral inferior colliculus  

E-print Network

Unilateral cochlear ablation produces greater loss of inhibition in the contralateral inferior, synaptic currents Abstract Bilateral cochlear ablation leads to a profound weakening of synaptic inhibition of unilateral cochlear ablation on inhibitory synaptic properties both ipsilateral and contralateral

345

Zoster sine herpete with thoracic motor paralysis temporally associated with thoracic epidural steroid injection.  

PubMed

Reactivation of latent varicella-zoster virus can occur when the immune system is weakened leading to the typical presentation seen with herpes zoster or shingles. In a small percentage of these patients, motor paralysis can be seen in the affected myotomal distribution. Zoster sine herpete, or shingles without the typical vesicular rash, is an uncommon variant of zoster. Systemic steroids are known to weaken the immune response. Two previous case reports have implicated epidural steroid injections as a precipitating cause of zoster. We present a case of serologically verified zoster sine herpete producing an abdominal wall bulge, which occurred 1 wk after thoracic epidural steroid injection. Electromyography documented the presence of abdominal wall denervation. Given the low incidence of serologically proven zoster sine herpete--especially with thoracic motor paralysis--and the equally rarely documented incidence of zoster related to epidural steroids, we present what we believe to be the first reported case of zoster sine herpete with a neuropathic abdominal wall bulge occurring in close temporal association to receiving epidural steroids. PMID:18806512

Schuchmann, John A; McAllister, Russell K; Armstrong, Christopher S; Puana, Rudolph

2008-10-01

346

Living donor kidney exchange.  

PubMed

Living donor kidney exchange, also referred to as kidney paired donation (KPD), is a relatively new transplant modality that is growing by leaps and bounds in the U.S. From its first realization as an exchange of kidneys between two incompatible donor/recipient pairs, KPD has expanded to include compatible pairs, nondirected donors, three-way and larger exchanges, and living/deceased donor exchanges. Innovations both clinical (transporting organs instead of donors, and improved HLA screening) and mathematical (simulation to test policies, optimization to find better and more matches) have made this modality even more useful and accessible. There are several independent multi-center paired donation registries and many more single-center registries operating in the U.S., but incompatible pairs are most likely to match when they participate in the largest possible paired exchange pool; a single, unified KPD program in the United States would likely best serve patients in search of matches. PMID:22755420

Gentry, Sommer; Segev, Dorry L

2011-01-01

347

The kidney in obesity.  

PubMed

Body mass index has been found to be the second most important contributor to relative risk for developing end state renal disease (ESRD), after proteinuria. The impact of obesity on the kidney includes a wide spectrum, from characteristic pathologic lesions to increment in urinary albumin excretion (UAE) and proteinuria/or decrease in glomerular filtration rate (GFR). The cause of renal disease associated to obesity is not well understood, but two relevant elements emerge. The first is the presence of obesity-related glomerulopathy, and the second is the fat deposit in the kidney with impact on renal haemodynamics and intrarenal regulation. The mechanisms linking obesity and renal damage are complex and include haemodynamic changes, inflammation, oxidative stress, apoptosis, and finally renal scarring. The protection of kidney damage needs to combine weight reduction with the proper control of the cardiometabolic risk factors associated, hypertension, metabolic syndrome, diabetes and dyslipidaemia. The search for specific treatments merits future research. PMID:25893477

Redon, Josep; Lurbe, Empar

2015-06-01

348

Development of bioartificial kidneys.  

PubMed

Bioartificial kidneys, which consist of continuous haemofiltration and bioartificial tubules using tubular epithelial cells, have been studied since 1987. The bioartificial tubules consist of hollow fibre modules and tubular epithelial cells grown on the hollow fibre membranes after coating with extracellular matrices. The kinds of tubular epithelial cells, extracellular matrices and artificial membranes therefore have been investigated and then the most appropriate cell and materials have been selected on the basis of the development of bioartificial kidneys. Successful seeding to form confluent monolayers on the surfaces of hollow fibers is not easy, but this method has already been established. Renal assist devices using human renal proximal tubular epithelial cells have been used in the treatment of acute renal failure patients with endotoxemia by Humes et al., and successful treatment of acute renal failure patients with these devices was reported in 2001 and 2002, in which the improved mortality rate of those patients was shown. A bioartificial kidney, in which cDNA of multidrug resistance protein-1 was transfected into tubular epithelial cells that were then grown on the outer surfaces of hollow fibers, was used in the experimental treatment of digoxin-intoxicated dogs. Rapidly reduced digoxin levels were noted in the plasma of the dogs after treatment. Bioartificial kidneys, however, have never been used in the long-term treatment of a maintenance dialysis patient, although patients need those kidneys. In order to establish long-term treatment with a bioartificial kidney, each haemofilter has to function for more than one week without systemic anticoagulation and a bioartificial tubule must function for 3-4 weeks. PMID:15012685

Saito, Akira

2003-10-01

349

Fractionation effects and repair kinetics in rat kidney  

SciTech Connect

Rat kidneys were unilaterally irradiated with up to 40 fractions of X rays. Fractionation regimens were given either with long intervals of 6-24 hr between fractions, resulting in complete recovery from sublethal damage, or with 1-hr intervals, resulting in largely incomplete repair. The non-irradiated kidney was surgically removed 4 weeks after the last fraction. The development of radiation-induced kidney damage was monitored by regular assessment of three different parameters indicative of kidney function: serum urea, the total volume of urine excreted in 24 hr and urine osmolality. At the end of the observation period, 18 months after treatment, the kidney was removed. The hydroxyproline content was determined and a histopathological analysis was performed. Since the 20 and 40-fraction data indicated a higher effectiveness of these regimens than would be expected on the basis of the LQ model, the data were divided in two subsets, 2-10 fractions (high doses per fraction) and 10-40 fractions (low doses per fraction), and analyzed separately. The time course of alpha/beta and T1/2 values was determined for each functional parameter separately, and for the data from the three parameters combined. A complex pattern was found, with the values for alpha/beta as well as T1/2 differing between the two data subsets between about 20 and 40 weeks after treatment. For the lower doses per fraction the alpha/beta values were generally higher and the repair half-times longer. After 40 weeks no significant differences were observed between the two data subsets. If the differences found earlier are ignored, overall alpha/beta and T1/2 values can be calculated. For early endpoints the alpha/beta was 1.69 (1.45, 1.90) Gy (95% confidence limits in parentheses), for late endpoints it was 1.77 (1.56, 2.00) Gy.

van Rongen, E.; Kuijpers, W.C.; Madhuizen, H.T. (Radiobiological Institute TNO, Rijswijk (Netherlands))

1990-05-01

350

Evaluation of intrarenal mesenchymal stem cell injection for treatment of chronic kidney disease in cats: a pilot study  

Microsoft Academic Search

The feasibility of autologous intrarenal mesenchymal stem cell (MSC) therapy in cats with chronic kidney disease (CKD) was investigated. Six cats (two healthy, four with CKD) received a single unilateral intrarenal injection of autologous bone marrow-derived or adipose tissue-derived MSC (bmMSC or aMSC) via ultrasound guidance. Minimum database and glomerular filtration rate (GFR) via nuclear scintigraphy were determined pre-injection, at

Jessica M. Quimby; Tracy L. Webb; Debra S. Gibbons; Steven W. Dow

2011-01-01

351

Mesenchymal chondrosarcoma of kidney  

PubMed Central

Mesenchymal chondrosarcoma of the kidney is a very rare entity with no definite treatment protocol. Herein, we describe one such case with discussion of its diagnosis and management. The patient had a well circumscribed mass in right kidney extending into the inferior vena cava and metastasis to both the lungs. Right nephrectomy was performed and the histopathological examination confirmed the diagnosis to be renal mesenchymal chondrosarcoma. After surgical removal of the tumor, the patient was given chemotherapy with Cisplatin and Epirubicin, following which there was significant regression of lung nodules. PMID:24744526

Tyagi, Ruchita; Kakkar, Nandita; Vasishta, Rakesh Kumar; Aggarwal, Mayank Mohan

2014-01-01

352

Unilateral cross bite treated by corticotomy-assisted expansion: two case reports  

Microsoft Academic Search

BACKGROUND: True unilateral posterior crossbite in adults is a challenging malocclusion to treat. Conventional expansion methods are expected to have some shortcomings. The aim of this paper is to introduce a new technique for treating unilateral posterior crossbite in adults, namely, corticotomy-assisted expansion (CAE) applied on two adult patients: one with a true unilateral crossbite and the other with an

Ali H Hassan; Ali T AlGhamdi; Ahmad A Al-Fraidi; Aziza Al-Hubail; Manar K Hajrassy

2010-01-01

353

Unilateral laterothoracic exanthem and primary Epstein-Barr virus infection: case report.  

PubMed

Unilateral laterothoracic exanthem is a self-limited disease that occurs most commonly in children. It is characterized by unilateral exanthem, often in axillary region. The etiology is unknown, but a viral agent is suspected. We report a 1-year-old white girl with unilateral laterothoracic exanthem associated with Epstein Barr virus infection, suggesting this virus has a possible etiologic role. PMID:19483526

Duarte, Ana F; Cruz, Maria J; Baudrier, Teresa; Mota, Alberto; Azevedo, Fliomena

2009-06-01

354

Kidney Stones in Children and Teens  

MedlinePLUS

... Stones in Children and Teens Health Issues Listen Kidney Stones in Children and Teens Article Body ?Kidney stones ... teen girls having the highest incidence. Types of Kidney Stones There are many different types of kidney stones ...

355

Overview of Kidney Diseases in Children  

MedlinePLUS

... Overview of Kidney Disease in Children Overview of Kidney Disease in Children On this page: How does ... through Research For More Information Acknowledgments How does kidney disease affect children? Kidney disease can affect children ...

356

Living with Kidney Disease: Frequently Asked Questions  

MedlinePLUS Videos and Cool Tools

... Asked Questions Frequently Asked Questions Youtube video Can kidney disease get better? Kidney disease usually will not ... do I need to make because I have kidney disease? People with kidney disease can and should ...

357

Lupus and Kidney Disease (Lupus Nephritis)  

MedlinePLUS

... Rate Your Risk Quiz Featured Story African Americans & Kidney Disease Did you know that African Americans are ... KEEP Healthy - Free Kidney Health checks Featured Story Kidney Walk The Kidney Walk is the nation's largest ...

358

Vitamins and Minerals in Kidney Disease  

MedlinePLUS

... Rate Your Risk Quiz Featured Story African Americans & Kidney Disease Did you know that African Americans are ... KEEP Healthy - Free Kidney Health checks Featured Story Kidney Walk The Kidney Walk is the nation's largest ...

359

Kidney Stone Treatment with Lithotripsy  

MedlinePLUS Videos and Cool Tools

Kidney Stone Treatment with Lithotripsy Broward Health Medical Center Fort Lauderdale, FL November 11, 2011 I'm ... got at least three stones in his left kidney. He's been having pain and blood in his ...

360

Kidney Disease (and Oral Health)  

MedlinePLUS

... have a bad taste in their mouths and bad breath (halitosis). This occurs because the kidneys fail to remove ... the mouth and salivary glands Kidney disease itself causes some of these symptoms. Others are caused by ...

361

Mucormycosis in a transplanted kidney.  

PubMed

Mucormycosis of the transplanted kidney has so far been reported in only 9 patients, with a high mortality rate. Here, we report a rare case of isolated mucormycosis of the transplant kidney with successful outcome. PMID:18466194

Nalmas, S; Bishburg, E; Goldstein, C

2008-07-01

362

Screening for Chronic Kidney Disease  

MedlinePLUS

... 1 Understanding Task Force Recommendations Screening for Chronic Kidney Disease The U.S. Preventive Services Task Force (Task Force) ... body needs to stay healthy. Screening for Chronic Kidney Disease CKD is a common condition that affects about ...

363

National Kidney Disease Education Program  

MedlinePLUS

... beyond. Remember: what you eat may help slow kidney disease Learn steps for eating right to help manage ... página en español. For People at Risk for Kidney Disease Did you know diabetes can put you at ...

364

Unilateral Retinitis pigmentosa: Clinical and Electrophysiological Report of Four Cases  

Microsoft Academic Search

Unilateral retinitis pigmentosa (URP) is a rare tapetoretinal dystrophy affecting only one eye. The François and Verriest criteria are necessary to make a correct diagnosis of URP: exclude all infective etiologies, check that the clinical signs of retinitis are present in the affected eye and ensure the total absence of any signs or symptoms of retinitis pigmentosa in the fellow

Leopoldo Spadea; Roberto Magni; Giorgio Rinaldi; Tommaso Dragani; Guido Bianco

1998-01-01

365

Selective Color Constancy Deficits after Circumscribed Unilateral Brain Lesions  

Microsoft Academic Search

temporal cortex. With a battery of clinical and specially de- signed color vision tests we tried to detect and differentiate between possible deficits in central color processing. Our re- sults show that color constancy can be selectively impaired after circumscribed unilateral lesions in parieto-temporal cortex of the left or right hemisphere. Five of 27 patients exhibited significant deficits in a

Lukas Ruttiger; Doris I. Braun; Karl R. Gegenfurtner; Dirk Petersen; Paul Schonle; Lindsay T. Sharpe

366

Unilateral Forced Nostril Breathing Affects Dichotic Listening for Emotional Tones  

ERIC Educational Resources Information Center

Unilateral forced nostril breathing (UFNB) through the left nostril is associated with enhanced spatial abilities, whereas UFNB through the right nostril is associated with enhanced verbal abilities. However, the effects of UFNB on standard tasks of laterality (e.g., dichotic listening) are unknown. This study employed dichotic listening for word…

Saucier, Deborah M.; Tessem, Farzana Karim; Sheerin, Aaron H.; Elias, Lorin

2004-01-01

367

Primary aldosteronism due to unilateral adrenal hyperplasia: a case report.  

PubMed

Primary aldosteronism is one of the differential diagnosis of secondary hypertension. This is usually caused by an aldosterone producing adenoma or bilateral adrenal hyperplasia which comprise about 65% and 30% of the cases, respectively. However, less than 1% of primary aldosteronism is caused by unilateral adrenal hyperplasia which is a relatively rare subset of primary aldosteronism. The clinical and biochemical manifestations of the disorder are indistinguishable from aldosterone-producing tumor, and a definitive diagnosis can only be made by pathological finding. A 33-year-old male Chinese patient presented with hypertension, hypokalemia, metabolic alkalosis, and the hypersecretion of aldosterone associated with suppressed plasma renin activity which is a typical hallmark of primary aldosteronism. Image studies including both magnetic resonance imaging (MRI) and 131I NIP-59 scan as well as postural test suggested an aldosterone-producing tumor of the right adrenal gland. Unilateral adrenectomy and pathological examination of the right adrenal gland eventually proved a case of unilateral adrenal hyperplasia. Blood pressure, plasma potassium, aldosterone and renin activity levels returned to normal two weeks after operation and had remained normal at up to one year of follow up. In addition, a saline loading test showed normal suppression of plasma aldosterone level one year after the operation, suggesting that the function of the left adrenal gland remains normal. The etiology of unilateral adrenal hyperplasia is unclear and the future recurrence of the disease is possible. Long-term follow-up is necessary to ensure the cure of this disorder. PMID:9175301

Chen, L G; Lee, T I; Lin, H D; Wang, H C; Liu, W Y; Tang, K T

1997-02-01

368

Management of Young Children with Unilateral Hearing Loss  

ERIC Educational Resources Information Center

Children with unilateral hearing loss (UHL) are at risk for academic, speech and language and social-emotional difficulties. To date, most of the evidence documented in the literature has been obtained from school-age children, most of whom were diagnosed with UHL after enrollment in school. Following the widespread institution of universal…

McKay, Sarah

2006-01-01

369

Unilateral internuclear ophthalmoplegia as an isolated presentation of metastatic melanoma.  

PubMed

Multiple sclerosis in younger patients and brainstem infarction in the elderly are the most common causes of internuclear ophthalmoplegia (INO). We report unilateral INO as the isolated clinical manifestation of a large, solitary, metastatic melanoma in the pons. Brain metastasis can present as INO. PMID:25232840

Kumar, Sunil; Kent, Shefalee S; Sundaram, Arun N; Sharma, Manas

2015-03-01

370

Bimanual Force Coordination in Children with Spastic Unilateral Cerebral Palsy  

ERIC Educational Resources Information Center

In this study bimanual grip-force coordination was quantified using a novel "Gripper" system that records grip forces produced while holding a lower and upper unit, in combination with the lift force necessary to separate these units. Children with unilateral cerebral palsy (CP) (aged 5-14 years, n = 12) were compared to age matched typically…

Smits-Engelsman, B. C. M.; Klingels, K.; Feys, H.

2011-01-01

371

Fos expression in the cat brainstem after unilateral vestibular neurectomy  

Microsoft Academic Search

Immediate early genes are generally expressed in response to sensory stimulation or deprivation and can be used for mapping brain functional activity and studying the molecular events underlying CNS plasticity. We immunohistochemically investigated Fos protein induction in the cat brainstem after unilateral vestibular neurectomy (UVN), with special reference to the vestibular nuclei (VN) and related structures. Fos-like immunoreactivity was analyzed

Sylvie Gustave Dit Duflo; Christian Gestreau; Brahim Tighilet; Michel Lacour

1999-01-01

372

Human ocular torsional position before and after unilateral vestibular neurectomy  

Microsoft Academic Search

The static ocular torsional position of both eyes of 23 patients was measured by means of fundus photographs one day before and one week after unilateral vestibular neurectomy for the treatment of acoustic neuroma, Ménière's disease or paroxysmal vertigo. The results showed that in all patients the vestibular neurectomy caused both eyes to tort (i.e. to roll around the visual

I. S. Curthoys; M. J. Dai; G. M. Halmagyi

1991-01-01

373

Unilateral vestibular failure suppresses cortical visual motion processing  

Microsoft Academic Search

Patients with unilateral vestibular failure (UVF) experience oscillopsia (apparent motion of the visual scene) during rapid head movements due to increased retinal slip caused by vestibulo-ocular reflex impairment. Oscillopsia is always smaller than the net retinal slip and decreases over time in patients with acquired vestibu- lar loss; this correlates with increased thresholds for visual motion detection and increased tolerance

A. Deutschlander; K. Hufner; Roger Kalla; Thomas Stephan; Thomas Dera; Stefan Glasauer; Martin Wiesmann; Michael Strupp; Thomas Brandt

2008-01-01

374

Abnormal /sup 201/Tl limb scan due to unilateral tremor  

SciTech Connect

A abnormal intra- and interextremity distribution pattern on /sup 201/Tl was observed on the limb scan of a patient with a unilateral tremor. This is ascribed to the increased blood flow in the muscles responsible for the tremor. The suggestion is made that the existence of tremor should be considered as a possible explanation for unexpected abnormalities on /sup 201/Tl limb scintigrams.

Simons, M.; Schelstraete, K.; Bratzlavsky, M.

1982-12-01

375

A field evaluation of arm prostheses for unilateral amputees  

Microsoft Academic Search

A post-clinical investigation has been carried out among 42 unilateral amputees who lost their hand due to an accident. The investigation was directed at two main topics of interest. Firstly the amputee, the problems he has to cope with, and the role the prosthesis plays in his life; and secondly the prosthesis, its use and its potential benefits and burdens.

H. G. STASSEN; M. J. ZUITHOFF

376

UNILATERAL CONTACT PROBLEMS WITH FRICTION FOR HEMITROPIC ELASTIC SOLIDS  

Microsoft Academic Search

We study three-dimensional unilateral contact problems with friction for hemitropic elastic solids. We give their mathematical formu- lation in the form of spatial variational inequalities and show the equivalence to the corresponding minimization problem. Based on our variational in- equality approach, we prove existence and uniqueness theorems. We prove also that solutions continuously depend on the data of the original

AVTANDIL GACHECHILADZE; ROLAND GACHECHILADZE; DAVID NATROSHVILI

2009-01-01

377

Unilateral transient reactive papulotranslucent acrokeratoderma in a child.  

PubMed

Transient reactive papulotranslucent acrokeratoderma is a rare, acquired, reactive, and episodic disorder of the palmar skin. Herein I report on a 6-year-old child with unilateral involvement and associated with ipsilateral hyperhidrosis and pruritus. Further observations are required for unraveling the etiopathogenesis of this disorder and its accurate classification. PMID:17958817

Erkek, Emel

2007-01-01

378

Posterior scleritis presenting as unilateral secondary angle-closure glaucoma.  

PubMed

The following is a case report of a 19-year-old male who presented with unilateral acute angle-closure glaucoma. Posterior scleritis was diagnosed based on clinical features and ultrasound B-scan. The acute angle closure attack and exudative retinal detachment completely resolved with use of oral corticosteroids. PMID:15510468

Jain, Sunil S; Rao, Prasan; Kothari, Kulin; Bhatt, Deepak; Jain, Sanjay

2004-09-01

379

Unilateral nevoid acanthosis nigricans: Uncommon variant of a common disease  

PubMed Central

Acanthosis nigricans (AN) is a fairly common dermatosis characterized by hyperpigmented velvety plaques, having a predilection for the intertriginous areas. We herein present a case of unilateral nevoid acanthosis nigricans over the left lateral chest, in an adult male. The rarity of documentation of this entity in the world literature prompted us to report the case. PMID:25506563

Das, Anupam; Bhattacharya, Sabari; Kumar, Piyush; Gayen, Tirthankar; Roy, Kunal; Das, Nilay K.; Gharami, Ramesh C.

2014-01-01

380

Idiopathic Unilateral Adrenal Hematoma: Report of a Case  

Microsoft Academic Search

We report an unusual case of idiopathic unilateral adrenal hematoma, which was asymptomatic and unaccompanied by a hematologic disorder. The surgical specimen contained a large tumor comprised of subacute to chronic organized hematoma. The preoperative magnetic resonance imaging findings were compatible with characteristics reported previously, except for spotty strong enhancement in the peripheral part of the mass. It is important

Toshihiko Kobayashi; Shoichi Uenoyama; Katsutoshi Miura; Yasuo Takehara

2004-01-01

381

Coupling of FM Systems to Individuals with Unilateral Hearing Loss.  

ERIC Educational Resources Information Center

This study examined the attenuation characteristics of 5 Frequency Modulation system sound delivery options for 25 adults and children (ages 5-13). Degree of ear canal occlusion was a major factor in degree of attenuation. For children with unilateral hearing impairments, the most acoustically appropriate option was the tube-fitting. (Author/JDD)

Kopun, Judy G.; And Others

1992-01-01

382

Unilateral amygdala inactivation after training attenuates memory for reduced reward  

Microsoft Academic Search

This experiment examined the effects of unilateral inactivation of the amygdalae on memory for reduction in reward magnitude. Male Sprague-Dawley rats with bilateral cannulae in the amygdala were trained to run a straight alley for ten 45-mg food pellets. On Day 10, half the animals were shifted to a 1 pellet food reward and half continued to receive 10 pellets.

Karin Coleman-Mesches; Juan A. Salinas; James L. McGaugh

1996-01-01

383

Long-term stability of unilateral posterior crossbite correction  

Microsoft Academic Search

OBJECTIVE: To evaluate the stability of orthodontically corrected unilateral posterior crossbite in patients treated either by rapid maxillary expansion or with slow expansion devices in the early (mean age 7.2 years, n = 50) or late mixed dentition (mean age 9.9 years, n = 50). MATERIALS AND METHODS: The observation periods were approximately 8 years for the early treatment groups

Theodosia Bartzela; Irmtrud Jonas

2007-01-01

384

Traumatic glaucoma with features of unilateral pigment dispersion  

PubMed Central

Summary We report a patient with traumatic glaucoma with features of unilateral pigment dispersion. This rare form of secondary glaucoma has only been reported twice previously, with both patients demonstrating angle recession, indicating associated damage to the trabecular meshwork. To our knowledge, this is the first such case reported in which angle recession was absent. PMID:25097455

Bowler, Gordon; Ellul, Antony; Gouws, Pieter

2014-01-01

385

[Unilateral laterothoracic exanthema. Case report and review of the literature].  

PubMed

Unilateral laterothoracic exanthem (ULE) developed in a 4-year-old-boy on maintenance therapy for acute lymphatic leukemia (ALL). This is the second reported case of an association between ULE and leukemia. The etiology of ULE is unknown. Endemic cases, frequently associated signs of upper respiratory infections, and the occurrence of ULE in immunocompromised hosts are suggestive of an infectious process. PMID:10969406

Peker, S; Höger, P H; Moll, I

2000-07-01

386

Between Law and Politics: The Challenge of Unilateral Declarations.  

E-print Network

1 Between Law and Politics: The Challenge of Unilateral Declarations. Eva Kassoti 1. Introduction proper is indisputable today, the question of distinguishing between international law and politics, the line between law and politics has been blurred even further due to recent trends in international law

Volesky, Bohumil

387

The effect of radiopharmaceutical choice on the determination of relative renal function in rats with unilateral renal obstruction  

SciTech Connect

A significant divergence of GFR and ERPF within a single kidney could lead to different estimates of relative renal function depending on which radiopharmaceutical is administered. To address this question, the authors studied adult male Sprague-Dawley rats with unilateral ureteral obstruction by giving each animal an intravenous injection of 10 ..mu..Ci of I-125 iothalamate (GFR), I-131 hippurate (ERPF), and TC-99m DMSA and measuring the 30 minute clearance (renal uptake and urine excretion) of each agent. Normal control animals were sham operated; 25 experimental animals were subjected to permanent unilateral ureteral occlusion and studied at 6 hours, 1, 3, 7 and 14 days. Acute ureteral obstruction impaired the clearance of iothalamate to a much greater degree than OIH or DMSA at 6 hours and 1 day (rho<.005) and 3 days (rho<.05). The decline in DMSA clearance reflected ERPF more closely than GFR. In evaluating renal disease, one should consider the functional parameter reflected by the radiopharmaceutical as well as the underlying disease state.

Taylor, A.; Lallone, R.

1984-01-01

388

Three cases of IgG4-related orbital inflammation presented as unilateral pseudotumor and review of the literature.  

PubMed

IgG4-related disease is an emerging disease entity characterized by elevated serum IgG4 concentration and tumefaction or tissue infiltration by IgG4-positive plasma cells. In IgG4-related disease, tumor-like lesions develop in multiple organs, such as the lacrimal gland, salivary gland, lung, pancreas, kidney, and lymph nodes. We report here three cases of IgG4-related orbital inflammation that presented as unilateral pseudotumors. The patients all were men, with an age range of 65-75 years. The patients had been pointed out unilateral intra-orbital masses, and histopathological examinations revealed marked accumulation of IgG4-positive plasma cells (IgG4/IgG ratio: 51.1-71.6%) with fibrosis. But storiform fibrosis was seen in only one case, and no obliterative phlebitis was seen. The serum levels of IgG4 were increased to 178-670 mg/dL. The masses had well-defined homogeneous signal intensities, and they were hypo-intense on T1-weighted MR images and iso-intense on T2-weighted MR images. Gadolinium enhanced mass lesions in two cases. All orbital mass lesions responded well to corticosteroid treatment. PMID:23138265

Origuchi, Tomoki; Yano, Hiroki; Nakamura, Hideki; Hirano, Akiyoshi; Kawakami, Atsushi

2013-11-01

389

[The application value of dual-source CT in the preoperative evaluation of living donor kidneys].  

PubMed

This study was to evaluate the value of dual-source CT in the preoperative assessment of living donor kidneys. We collected fifty-five consecutive living kidney donors (male 35, female 20, average age, 39 years old), and performed dual-source CT scan. The plain scan, pre-enhanced arterial phase and venous phase examinations were performed, with the scan level ranged from the 11th thoracic vertebral body to the iliac crest. All the basic images were reconstructed using volume rendering(VR), maximum intensity projection (MIP), multi-planar reconstruction (MPR) techniques to evaluate the anatomical location and variation of renal arteries and veins, and the morphology and function of kidney and urinary tract. All the 55 cases were successful, with completion of CT scan and clear images. 46 cases among the all cases had normal renal arteries and veins, while 6 cases had accessory arteries, 2 cases had pre-hilar renal artery branching, and 1 case had vein variation. For the renal parenchymas, 48 cases were normal, while 2 cases had angiomyolipoma and 5 cases had cortical cyst. There were no variation and disease in upper urinary tract. Compared with the surgical findings, the diagnostic accuracy was 100% with dual-source CT. In conclusion, the dual-source CT can accurately evaluate the vessel of kidney, renal parenchyma and upper urinary tract of living renal donors, can provide reliable imaging information for screening of living donor kidney and can help make operation program in living kidney transplantation. PMID:22616172

Zhang, Wei; Chen, Guangwen; Song, Bin

2012-04-01

390

Preclinical evaluation of erythropoietin administration in a model of radiation-induced kidney dysfunction  

SciTech Connect

Purpose: To test whether the clinically available growth factor erythropoietin (EPO) influences radiation-induced normal-tissue damage in a model of kidney dysfunction. Methods: Animal experiments were conducted to test the role of EPO administration in a C3H mouse model of unilateral kidney irradiation with 6, 8, and 10 Gy and to assess the effects of 2 different dose levels of EPO. The kidney function was assessed before radiotherapy, as well as 19, 25, 31, and 37 weeks thereafter by means of {sup 99m}Tc-dimercaptosuccinat scans (static scintigraphy). Results: Concomitant EPO administration significantly increased the degree of radiation-induced kidney dysfunction. A dose of 2,000 IU/kg body weight per injection tended to cause more damage than the lower dose of 500 IU/kg. Conclusion: Administration of growth factors concomitant to radiotherapy might modify the development of kidney dysfunction. Although insulin-like growth factor-1 has previously been shown to protect the kidney, such an effect could not be demonstrated for EPO. The latter agent even increased the development of nephropathy.

Andratschke, Nicolaus [Department of Radiation Oncology, Klinikum rechts der Isar, Technical University of Munich, Munich (Germany); Schnaitera, Andrea [Department of Radiation Oncology, Klinikum rechts der Isar, Technical University of Munich, Munich (Germany); Weber, Wolfgang A. [Department of Molecular and Medical Pharmacology, Ahmanson Biological Imaging Center, The University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, CA (United States); Caia, Lu [Department of Radiation Oncology, Klinikum rechts der Isar, Technical University of Munich, Munich (Germany); Schill, Sabine [Department of Radiation Oncology, Klinikum rechts der Isar, Technical University of Munich, Munich (Germany); Wiedenmann, Nicole [Department of Experimental Radiation Oncology, University of Texas M.D. Anderson Cancer Center, Houston, TX (United States); Schwaiger, Markus [Department of Nuclear Medicine, Klinikum rechts der Isar, Technical University of Munich, Munich (Germany); Molls, Michael [Department of Radiation Oncology, Klinikum rechts der Isar, Technical University of Munich, Munich (Germany); Nieder, Carsten [Department of Radiation Oncology, Klinikum rechts der Isar, Technical University of Munich, Munich (Germany)]. E-mail: cnied@hotmail.com

2006-04-01

391

Imaging features of thoracic metastases from gynecologic neoplasms.  

PubMed

Gynecologic malignancies are a heterogeneous group of common neoplasms and represent the fourth most common malignancy in women. Thoracic metastases exhibit various imaging patterns and are usually associated with locally invasive primary neoplasms with intra-abdominal spread. However, thoracic involvement may also occur many months to years after initial diagnosis or as an isolated finding in patients without evidence of intra-abdominal neoplastic involvement. Thoracic metastases from endometrial carcinoma typically manifest as pulmonary nodules and lymphadenopathy. Thoracic metastases from ovarian cancer often manifest with small pleural effusions and subtle pleural nodules. Thoracic metastases to the lungs, lymph nodes, and pleura may also exhibit calcification and mimic granulomatous disease. Metastases from fallopian tube carcinomas exhibit imaging features identical to those of ovarian cancers. Most cervical cancers are of squamous histology, and while solid pulmonary metastases are more common, cavitary metastases occur with some frequency. Metastatic choriocarcinoma to the lung characteristically manifests with solid pulmonary nodules. Some pulmonary metastases from gynecologic malignancies exhibit characteristic features such as cavitation (in squamous cell cervical cancer) and the "halo" sign (in hemorrhagic metastatic choriocarcinoma) at computed tomography (CT). However, metastases from common gynecologic malignancies may be subtle and indolent and may mimic benign conditions such as intrapulmonary lymph nodes and remote granulomatous disease. Therefore, radiologists should consider the presence of locoregional disease as well as elevated tumor marker levels when interpreting imaging studies because subtle imaging findings may represent metastatic disease. Positron emission tomography/CT may be helpful in identifying early locoregional and distant tumor spread. PMID:25310428

Martínez-Jiménez, Santiago; Rosado-de-Christenson, Melissa L; Walker, Christopher M; Kunin, Jeffery R; Betancourt, Sonia L; Shoup, Brenda L; Pettavel, Paul P

2014-10-01

392

Mechanism of the formation for thoracic impedance change.  

PubMed

The purpose of this study is to investigate the mechanism of the formation for thoracic impedance change. On the basis of Ohm's law and the electrical field distribution in the cylindrical volume conductor, the formula about the thoracic impedance change are deduced, and they are demonstrated with the model experiment. The results indicate that the thoracic impedance change caused by single blood vessel is directly proportional to the ratio of the impedance change to the basal impedance of the blood vessel itself, to the length of the blood vessel appearing between the current electrodes, and to the basal impedance between two detective electrodes on the chest surface, while it is inversely proportional to the distance between the blood vessel and the line joining two detective electrodes. The thoracic impedance change caused by multiple blood vessels together is equal to the algebraic addition of all thoracic impedance changes resulting from the individual blood vessels. That is, the impedance changes obey the principle of adding scalars in the measurement of the electrical impedance graph. The present study can offer the theoretical basis for the waveform reconstruction of Impedance cardiography (ICG). PMID:20336823

Kuang, Ming-Xing; Xiao, Qiu-Jin; Cui, Chao-Ying; Kuang, Nan-Zhen; Hong, Wen-Qin; Hu, Ai-Rong

2010-03-01

393

Radiation injury in the human kidney: A prospective analysis using specific scintigraphic and biochemical endpoints  

SciTech Connect

Renal function was prospectively analyzed in 26 evaluable patients, irradiated to various doses on their kidneys for neoplastic disease. Glomerular function was assessed by 99mTc-DTPA renography, creatinine clearance, and serum beta 2-microglobulin, whereas tubular function was monitored by 99mTc-DMSA scintigraphy, urine beta 2-microglobulin, urine N-acetyl glucosaminidase, and alanine aminopeptidase and a urine concentration test. In the patients given the highest irradiation dose to the entire left kidney, that is, 40 Gy in 5 1/2 weeks, glomerular and tubular functional impairment, as assessed scintigraphically, progressed at a rate of 2.0 +/- 1.0% (+/- 1 SD) and 2.0 +/- 0.5% per month, respectively, down to 30-40% after 3 to 5 years. The overall glomerular function, as assessed by creatinine clearance, decreased by only 20%. In the patients irradiated unilaterally on the upper pole to 40 Gy in 4 weeks, glomerular and tubular function in the left kidney deteriorated at 0.75 +/- 0.33% and 0.75 +/- 0.20% per month in the first 2 years, down to 75-80% at 5 years. This smaller reduction was due to shielding of a part of the left kidney. No changes were observed, thus far, after bilateral whole kidney irradiation to 17-18 Gy in 3 1/2 weeks. The concentration capacity of the kidney after total volume irradiation was not impaired. There was a trend for an increase in diastolic blood pressure in 3 out of 5 patients given the high dose irradiation to the entire left kidney and in 2 out of 7 patients irradiated on the upper pole of the left kidney. The progressive nature of the radiation nephropathy stresses the need for long term follow-up to determine more accurately the tolerance dose of the human kidney for irradiation.

Dewit, L.; Anninga, J.K.; Hoefnagel, C.A.; Nooijen, W.J. (Netherlands Cancer Institute, Antoni van Leeuwenhoek Huis, Amsterdam (Netherlands))

1990-10-01

394

Outcomes After Unilateral Uterine Artery Embolization: A Retrospective Review  

SciTech Connect

Purpose. Bilateral uterine artery embolization (UAE) is considered necessary to provide effective treatment for symptomatic uterine fibroids. Occasionally, only unilateral embolization is performed, and this study evaluates these outcomes. Materials and Methods. As part of a prospective observational study of more than 1600 patients treated with UAE since 1996, there have been 48 patients in whom unilateral embolization has been performed. This study retrospectively reviews clinical response as assessed by our standard questionnaire and radiological response assessed by either magnetic resonance imaging or ultrasound. Results. Two principal groups emerged: the largest, where only the dominant unilateral arterial supply was electively embolized (30 patients); and the second, where there was technical failure to catheterize the second uterine artery as a result of anatomical constraints (12 patients). Favorable clinical response with a reduction in menorrhagia at 1 year was seen in 85.7% (18/21) of those patients with a dominant arterial supply to the fibroid(s). In contrast, in those patients where there was technical failure to embolize one uterine artery, there was a high rate of clinical failure requiring further intervention in 58.3% (7/12). Comparison of the technical failure group with the dominant uterine artery group demonstrated a statistically significant (Fisher's exact test) difference in the proportion of patients with evidence of persistent fibroid vascularity (p < 0.001) and requiring repeat intervention (p < 0.01). Conclusion. We conclude that unilateral UAE can achieve a positive clinical result in the group of patients where there is a dominant unilateral artery supplying the fibroid(s), in contrast to the poor results seen following technical failure.

Bratby, M. J. [St George's Hospital, Radiology Department (United Kingdom); Hussain, F. F.; Walker, W. J. [Royal Surrey County Hospital, Radiology Department (United Kingdom)], E-mail: wj.walker@virgin.net

2008-03-15

395

An analytical methodology for magnetic field control in unilateral NMR.  

PubMed

Traditionally, unilateral NMR systems such as the NMR-MOUSE have used the fringe field between two bar magnets joined with a yoke in a 'U' geometry. This allows NMR signals to be acquired from a sensitive volume displaced from the magnets, permitting large samples to be investigated. The drawback of this approach is that the static field (B0) generated in this configuration is inhomogeneous, and has a large, nonlinear, gradient. As a consequence, the sensitive volume of the instrument is both small and ill defined. Empirical redesign of the permanent magnet array producing the B0 field has yielded instruments with magnetic field topologies acceptable for varying applications. The drawback of current approaches is the lack of formalism in the control of B0. Rather than tailoring the magnet geometry to NMR investigations, measurements must be tailored to the available magnet geometry. In this work, we present a design procedure whereby the size, shape, field strength, homogeneity, and gradients in the sensitive spot of a unilateral NMR sensor can be controlled. Our design uses high permeability pole pieces, shaped according to the contours of an analytical expression, to control B0, allowing unilateral NMR instruments to be designed to generate a controlled static field topology. We discuss the approach in the context of previously published design techniques, and explain the advantages inherent in our strategy as compared to other optimization methods. We detail the design, simulation, and construction of a unilateral magnet array using our approach. It is shown that the fabricated array exhibits a B0 topology consistent with the design. The utility of the design is demonstrated in a sample nondestructive testing application. Our design methodology is general, and defines a class of unilateral permanent magnet arrays in which the strength and shape of B0 within the sensitive volume can be controlled. PMID:15809175

Marble, Andrew E; Mastikhin, Igor V; Colpitts, Bruce G; Balcom, Bruce J

2005-05-01

396

ORIGINAL ARTICLE Kidney Cancer Mortality  

E-print Network

ORIGINAL ARTICLE Kidney Cancer Mortality Fifty-year Latency Patterns Related to Arsenic Exposure,e and Allan H. Smitha Background: Arsenic in drinking water is associated with kidney cancer. Beginning obtained computerized mortality data for all of Chile for 1971­2000. Results: Kidney cancer risks

California at Berkeley, University of

397

BACTERIAL KIDNEY DISEASE  

Technology Transfer Automated Retrieval System (TEKTRAN)

Bacterial kidney disease (BKD), caused by Renibacterium salmoninarum, is a prevalent disease that impacts the sustainable production of salmonid fish for consumption and species conservation efforts. The disease is chronic in nature and mortality most often occurs in 6–12 month old juvenile salmonid...

398

Cancer in Kidney Transplantation  

Microsoft Academic Search

Cancer in the transplanted kidney is rare, and its clinical and surgical management can be controversial. We report 3 cases of cancer in renal transplantation (1 case of renal cell carcinoma and 2 cases of transitional cell carcinoma) and their treatment. Our data and those reported in the literature suggest that these cancers can be treated like a neoplasm in

D. Zani; C. Simeone; A. Antonelli; E. Bettini; A. Moroni; S. Cosciani Cunico

2008-01-01

399

Your Kidney Test Results  

MedlinePLUS

... and can damage blood vessels in the kidneys. Serum Albumin Normal: 3.4 to 5.0* Your Result: Albumin is a protein that helps measure how well you are eating. Bicarbonate Normal: More than 22 Your Result: Bicarbonate measures the acid level in your blood. Blood Urea Nitrogen (BUN) Normal: ...

400

Kidney (Renal) Failure  

MedlinePLUS

... Fatigue Blood in your stool Shortness of breath High blood pressure Nausea Drowsiness Ease of bruising Changes in urination, such as decreased, excessive or complete lack of output top of page How is kidney failure evaluated? View larger with caption There are a ...

401

Living with Kidney Cancer  

MedlinePLUS

Living With Cancer Day to Day The impact of kidney cancer on your life is complex. Here are suggestions on what to expect — from employment matters and ... least one half hour of exercise every other day. Vigorous walking, jogging, swimming, or other aerobic exercise ...

402

Black kidney in Albinism  

PubMed Central

Implication for health policy/practice/research/medical education: Oculocutaneous albinism may be similar to two related syndromes (Hermansky-Pudlak and Chediak-Higashi) and could lead to more widespread lysosome excretory defects. These defects could lead to accumulation of some intracellular material, leading to the gross discoloration of the kidney. PMID:24772396

Ardalan, Mohammad-Reza

2014-01-01

403

Kidney Stones (For Parents)  

MedlinePLUS

... can build up and become stones. Kidney stones range in size from a fraction of an inch to several ... stone, an imaging test can show its exact size and location, which will help doctors decide on ... own and don't need much treatment, but large stones may require surgery or another procedure to ...

404

Hypoxia in Diabetic Kidneys  

PubMed Central

Diabetic nephropathy (DN) is now a leading cause of end-stage renal disease. In addition, DN accounts for the increased mortality in type 1 and type 2 diabetes, and then patients without DN achieve long-term survival compatible with general population. Hypoxia represents an early event in the development and progression of DN, and hypoxia-inducible factor- (HIF-) 1 mediates the metabolic responses to renal hypoxia. Diabetes induces the “fraternal twins” of hypoxia, that is, pseudohypoxia and hypoxia. The kidneys are susceptible to hyperoxia because they accept 20% of the cardiac output. Therefore, the kidneys have specific vasculature to avoid hyperoxia, that is, AV oxygen shunting. The NAD-dependent histone deacetylases (HDACs) sirtuins are seven mammalian proteins, SIRTs 1–7, which are known to modulate longevity and metabolism. Recent studies demonstrated that some isoforms of sirtuins inhibit the activation of HIF by deacetylation or noncatalyzing effects. The kidneys, which have a vascular system that protects them against hyperoxia, unfortunately experience extraordinary hypernutrition today. Then, an unexpected overload of glucose augments the oxygen consumption, which ironically results in hypoxia. This review highlights the primary role of HIF in diabetic kidneys for the metabolic adaptation to diabetes-induced hypoxia. PMID:25054148

Takiyama, Yumi; Haneda, Masakazu

2014-01-01

405

Kidney Size Comparison of BEN Victims  

USGS Multimedia Gallery

Normal size kidney (left) and a Balkan endemic nephropathy (BEN) kidney (right). The BEN kidney is reduced by one third compared to a normal kidney. The collapse of the kidney structure in the BEN kidney causes the organ to cease to function, resulting in uremia (blood poisoning) and requiring dialy...

406

Intracortical inhibition and facilitation with unilateral dominant, unilateral nondominant and bilateral movement tasks in left and right handed adults  

PubMed Central

Purpose To investigate intracortical inhibition and facilitation in response to unilateral dominant, nondominant and bilateral biceps activation and short-term upper extremity training in right and left-handed adults. Methods Paired-pulse transcranial magnetic stimulation was used to measure intracortical excitability in motor dominant and nondominant cortices of 26 nondisabled adults. Neural facilitation and inhibition were measured in each hemisphere during unilateral dominant, nondominant and bilateral arm activation and after training in each condition. Results No differences were seen between right and left- handed subjects. Intracortical facilitation and decreased inhibition were seen in each hemisphere with unilateral activation/training of contralateral muscles and bilateral muscle activation/training. Persistent intracortical inhibition was seen in each hemisphere with ipsilateral muscle activation/training. Inhibition was greater in the nondominant hemisphere during dominant hemisphere activation (dominant arm contraction). Conclusion Strongly dominant individuals show no difference in intracortical responses given handedness. Intracortical activity with unilateral and bilateral arm activation and short-term training differs based on hemispheric dominance, with the motor dominant hemisphere exerting a larger inhibitory influence over the nondominant hemisphere. Bilateral activation and training has a disinhibitory effect in both dominant and nondominant hemispheres. PMID:18336839

Waller, Sandy McCombe; Forrester, Larry; Villagra, Federico; Whitall, Jill

2009-01-01

407

Renal denervation has blood pressure-independent protective effects on kidney and heart in a rat model of chronic kidney disease.  

PubMed

We elucidate the underlying mechanisms of bidirectional cardiorenal interaction, focusing on the sympathetic nerve driving disruption of the local renin-angiotensin system (RAS). A rat model of N(?)-nitro-L-arginine methyl ester (L-NAME; a nitric oxide synthase inhibitor) administration was used to induce damage in the heart and kidney, similar to cardiorenal syndrome. L-NAME induced sympathetic nerve-RAS overactivity and cardiorenal injury accompanied by local RAS elevations. These were suppressed by bilateral renal denervation, but not by hydralazine treatment, despite the blood pressure being kept the same between the two groups. Although L-NAME induced angiotensinogen (AGT) protein augmentation in both organs, AGT mRNA decreased in the kidney and increased in the heart in a contradictory manner. Immunostaining for AGT suggested that renal denervation suppressed AGT onsite generation from activated resident macrophages of the heart and circulating AGT excretion from glomeruli of the kidney. We also examined rats treated with L-NAME plus unilateral denervation to confirm direct sympathetic regulation of intrarenal RAS. The levels of urinary AGT and renal angiotensin II content and the degrees of renal injury from denervated kidneys were less than those from contralateral innervated kidneys within the same rats. Thus, renal denervation has blood pressure-independent beneficial effects associated with local RAS inhibition. PMID:24940798

Eriguchi, Masahiro; Tsuruya, Kazuhiko; Haruyama, Naoki; Yamada, Shunsuke; Tanaka, Shigeru; Suehiro, Takaichi; Noguchi, Hideko; Masutani, Kosuke; Torisu, Kumiko; Kitazono, Takanari

2015-01-01

408

Kidney Access Device  

PubMed Central

Introduction: Percutaneous nephrolithotomy is the most complicated stone surgery technique to learn. The steep learning curve is related mainly to obtaining precise renal access by puncturing the targeted calyx. A minimally misaligned puncture may lead to torrential bleeding, failure of the surgery, and complications. Renal puncture can take a long time, and the increased fluoroscopic time is a hazard for the patient and surgeon. Methods: To aid in renal puncture and overcome the learning curve associated with learning the renal puncture technique, we designed a kidney access device (KAD), which helps align the 3-dimensional targeted calyx under fluoroscopy for precise needle placement. The KAD allows access to calyces at all angles. A 3-step puncture technique was formulated for puncturing the kidney using the KAD in a porcine model (with comparable renal size and anatomy with humans). To evaluate the practicality of the KAD and its possible advantages and limitations, the KAD was used to puncture 3 targeted calyces of bilateral kidneys in 4 pigs. Guidewires were inserted into the renal collecting system through the placed needle. Results: Mean time per puncture was 4 ± 2 minutes (n = 24). Necropsy showed no retroperitoneal hematoma, visceral organ injury, or active bleeding from kidneys in any of the pigs. Kidneys were dissected and precise intrarenal placements of guidewires in relation to targeted calyces were noted at all 24 sites. Conclusions: The KAD with the 3-step technique aids in the safe and accurate renal puncture, even in novice hands, while drastically reducing operative and fluoroscopy time. The KAD may also be used to access other organs and has potential applications in minimally invasive surgery. PMID:25489217

Scott, Robert; Patel, Mitesh; Mittal, Vijay K.

2014-01-01

409

Transient increase in proteinuria, poly-ubiquitylated proteins and ER stress markers in podocyte-specific autophagy-deficient mice following unilateral nephrectomy.  

PubMed

Previous studies have revealed that podocytes normally can be associated with a very high degree of autophagic activity, and that a lack of autophagic activity in podocytes is associated with susceptibility to disease and to late-onset glomerulosclerosis. In the present study, we conducted unilateral nephrectomy as a surgical model for acute nephron reduction. First, using GFP-LC3 transgenic mice to monitor autophagy, we found that glomerular autophagy could be transiently suppressed by surgery, but that it was restored quickly. To further explore the significance of podocyte autophagy after unilateral nephrectomy, we investigated podocyte-specific Atg7-deficient mice. The knockout mice exhibited no pathological phenotype compared with wild-type mice before nephrectomy. However, 1 day after nephrectomy, significantly higher levels of proteinuria and ultrastructural changes that included foot process effacement and a significant reduction in podocyte number were detected in mice harboring Atg7-deficient podocytes. Moreover, biochemical and immunohistochemical analyses showed a robust increase in polyubiquitin levels and ER stress markers in the glomeruli of the mice with autophagy-deficient podocytes. These results show the importance of the autophagic process in podocytes for maintaining a normal degree of filtration function during the adaptation to compensatory kidney hypertrophy following unilateral nephrectomy. PMID:24680677

Oliva Trejo, Juan Alejandro; Asanuma, Katsuhiko; Kim, Eun-Hee; Takagi-Akiba, Miyuki; Nonaka, Kanae; Hidaka, Teruo; Komatsu, Masaaki; Tada, Norihiro; Ueno, Takashi; Tomino, Yasuhiko

2014-04-18

410

Antisense knockdown of Kras inhibits fibrosis in a rat model of unilateral ureteric obstruction.  

PubMed

Tubulointerstitial fibrosis is the hallmark of chronic kidney disease and is characterized by an increase in the number and activity of interstitial fibroblasts and by excessive matrix deposition. Ras is an intracellular signaling molecule involved in cell proliferation and differentiation. It has recently been implicated in the pathogenesis of renal fibrosis. Of the three different isoforms of Ras (Kirsten, Harvey, and Neural), we previously demonstrated that the Kirsten isoform is key in the control of renal fibroblast proliferation in vitro. In this study, we used gene therapy in the form of antisense oligonucleotides (ASOs) specifically to silence Kras (alias Ki-ras) expression in a rat model of renal fibrosis caused by unilateral ureteric obstruction. We demonstrate that renal Kras expression increases by 70% in this model compared with sham-operated animals and that treatment with ASOs can reduce total renal Kras by >90% to levels well below basal. This silencing is associated with a dramatic inhibition of interstitial fibrosis, a fivefold reduction in ?-smooth muscle actin expression, and a 2.4-fold reduction in collagen I deposition. This inhibition was observed despite histologic evidence of marked interstitial inflammation. These findings demonstrate that silencing Kras expression can markedly inhibit renal fibrosis. This strategy should be considered as a new potential therapeutic avenue. PMID:22074740

Wang, Jia-Hui; Newbury, Lucy J; Knisely, A S; Monia, Brett; Hendry, Bruce M; Sharpe, Claire C

2012-01-01

411

Urinary candidate biomarker discovery in a rat unilateral ureteral obstruction model.  

PubMed

Urine has the potential to become a better source of biomarkers. Urinary proteins are affected by many factors; therefore, differentiating between the variables associated with any particular pathophysiological condition in clinical samples is challenging. To circumvent these problems, simpler systems, such as animal models, should be used to establish a direct relationship between disease progression and urine changes. In this study, a unilateral ureteral obstruction (UUO) model was used to observe tubular injury and the eventual development of renal fibrosis, as well as to identify differential urinary proteins in this process. Urine samples were collected from the residuary ureter linked to the kidney at 1 and 3 weeks after UUO. Five hundred proteins were identified and quantified by LC-MS/MS, out of which 7 and 19 significantly changed in the UUO 1- and 3-week groups, respectively, compared with the sham-operation group. Validation by western blot showed increased levels of Alpha-actinin-1 and Moesin in the UUO 1-week group, indicating that they may serve as candidate biomarkers of renal tubular injury, and significantly increased levels of Vimentin, Annexin A1 and Clusterin in the UUO 3-week group, indicating that they may serve as candidate biomarkers of interstitial fibrosis. PMID:25791774

Yuan, Yuan; Zhang, Fanshuang; Wu, Jianqiang; Shao, Chen; Gao, Youhe

2015-01-01

412

Non-healing ulcer on the foot: early onset unilateral Mali-type acroangiodermatitis.  

PubMed

Acroangiodermatitis (pseudo-Kaposi's sarcoma, AAD) is a benign vascular dermatosis that resembles Kaposi's sarcoma clinically and histopathologically (1). Four types have been defined: the Stewart-Bluefarb type accompanying chronic arteriovenous malformations, the Mali type accompanying stasis dermatitis, a type accompanying the first gestation, and a type accompanying arteriovenous shunts in patients with chronic kidney failure (3). Although AAD development is associated with chronic venous failure, less frequently AAD can develop as a complication of extremity paralysis, hemodialysis, post-traumatic arteriovenous fistula, amputated extremities, and vascular malformations (e.g., Klippel-Trénaunay syndrome). Pseudo-Kaposi's sarcoma can be histopathologically and clinically confused with malignant diseases such as Kaposi's sarcoma (1, 4). A 22-year-old male was referred to our outpatient clinic with a complaint of a non-healing wound on the distal phalanx of the left first toe. The patient was referred to various centers for 2 years and stated that he had received infection treatments but that his complaints did not disappear. An AAD diagnosis was established for the patient based on clinical and histopathologic evidence. Because he had early-onset disease and it was unilateral, the diagnosis was delayed. In addition, due to the rare occurrence of the disease, we histopathologically diagnosed this patient as having acroangiodermatitis. PMID:23836359

Ozkaya, Dilek B?y?k; Su, Ozlem; Onsun, Nahide; Ulusal, Hande; Demirkesen, Cuyan

2013-01-01

413

Urinary candidate biomarker discovery in a rat unilateral ureteral obstruction model  

PubMed Central

Urine has the potential to become a better source of biomarkers. Urinary proteins are affected by many factors; therefore, differentiating between the variables associated with any particular pathophysiological condition in clinical samples is challenging. To circumvent these problems, simpler systems, such as animal models, should be used to establish a direct relationship between disease progression and urine changes. In this study, a unilateral ureteral obstruction (UUO) model was used to observe tubular injury and the eventual development of renal fibrosis, as well as to identify differential urinary proteins in this process. Urine samples were collected from the residuary ureter linked to the kidney at 1 and 3 weeks after UUO. Five hundred proteins were identified and quantified by LC-MS/MS, out of which 7 and 19 significantly changed in the UUO 1- and 3-week groups, respectively, compared with the sham-operation group. Validation by western blot showed increased levels of Alpha-actinin-1 and Moesin in the UUO 1-week group, indicating that they may serve as candidate biomarkers of renal tubular injury, and significantly increased levels of Vimentin, Annexin A1 and Clusterin in the UUO 3-week group, indicating that they may serve as candidate biomarkers of interstitial fibrosis. PMID:25791774

Yuan, Yuan; Zhang, Fanshuang; Wu, Jianqiang; Shao, Chen; Gao, Youhe

2015-01-01

414

Prevention of reflex natriuresis after acute unilateral nephrectomy by neonatal administration of MSG  

SciTech Connect

Acute unilateral nephrectomy (AUN) results in natriuresis from the remaining kidney through reflex pathways involving the central nervous system and requiring an intact pituitary gland. The natriuresis is accompanied by an increase in the plasma concentration of a peptide or peptides derived from the N-terminal fragment (NTF) of proopiomelanocortin. The authors measured plasma immunoreactive NTF-like material (IR-NTF) by radioimmunoassay, before and after AUN in control rats and rats treated neonatally with monosodium glutamate (MSG), a procedure that produces neuroendocrine dysfunction by destroying cell bodies in the hypothalamic arcuate nucleus, median eminence, and other brain regions. In control rats, IR-NTF increased from 85.8 +/- 54.9 (SD) to 207 +/- 98.1 fmol/ml after AUN as sodium excretion (U/sub Na/V) doubled. In MSG-treated rats, AUN produced no change in plasma IR-NTF concentration, nor did U/sub Na/V increase. Tissue content of IR-NTF was reduced in the arcuate nucleus and anterior lobe of pituitaries from MSG-treated rats compared with controls, but was no different in the neurointermediate lobe. These results indicate that the hypothalamic lesion produced by neonatal administration of MSG prevents both the increase in plasma IR-NTF concentration and the natruiuresis after AUN, and therefore lend further support to the concept of a casual relationship between these two consequences of AUN.

Lin, S.Y.; Wiedemann, E.; Deschepper, C.F.; Alper, R.H.; Humphreys, M.H.

1987-02-01

415

A comparison of thoracic or lumbar patient-controlled epidural analgesia methods after thoracic surgery  

PubMed Central

Background We aimed to compare patient-controlled thoracic or lumbar epidural analgesia methods after thoracotomy operations. Methods One hundred and twenty patients were prospectively randomized to receive either thoracic epidural analgesia (TEA group) or lumbar epidural analgesia (LEA group). In both groups, epidural catheters were administered. Hemodynamic measurements, visual analog scale scores at rest (VAS-R) and after coughing (VAS-C), analgesic consumption, and side effects were compared at 0, 2, 4, 8, 16, and 24 hours postoperatively. Results The VAS-R and VAS-C values were lower in the TEA group in comparison to the LEA group at 2, 4, 8, and 16 hours after surgery (for VAS-R, P?=?0.001, P?=?0.01, P?=?0.008, and P?=?0.029, respectively; and for VAS-C, P?=?0.035, P?=?0.023, P?=?0.002, and P?=?0.037, respectively). Total 24-hour analgesic consumption was different between groups (175 +/- 20 mL versus 185 +/- 31 mL; P?=?0.034). The comparison of postoperative complications revealed that the incidence of hypotension (21/57, 36.8% versus 8/63, 12.7%; P?=?0.002), bradycardia (9/57, 15.8% versus 2/63, 3.2%; P?=?0.017), atelectasis (1/57, 1.8% versus 7/63, 11.1%; P?=?0.04), and the need for intensive care unit (ICU) treatment (0/57, 0% versus 5/63, 7.9%; P?=?0.03) were lower in the TEA group in comparison to the LEA group. Conclusions TEA has beneficial hemostatic effects in comparison to LEA after thoracotomies along with more satisfactory pain relief profile. PMID:24885545

2014-01-01

416

Myeloma-related kidney disease.  

PubMed

Multiple myeloma is a malignant plasma cell disorder characterized by the overproduction of monoclonal proteins. The kidney is 1 of the major target organs of multiple myeloma. Most often, this is the result of the monoclonal proteins, which can injure the kidney via several mechanisms. In some cases, direct invasion by myeloma cells and/or bone marrow cells can also result in kidney injury. A kidney biopsy can help distinguish the various myeloma-related kidney diseases and aid in the treatment plan. PMID:24359985

Leung, Nelson; Nasr, Samih H

2014-01-01

417

Hypertension and a missing kidney  

PubMed Central

Standard initial assessment via ultrasound of a 4-year-old girl with hypertension revealed the absence of one kidney. Instead of cross-sectional imaging of the retroperitoneal space, a functional (nuclear) study was performed. This revealed a malformed kidney within the chest. Though systemic levels of renin and aldosterone were not elevated, removal of the malformed kidney normalized the blood pressure. The presence of prominent smooth muscle nodules surrounding the arteries was seen in the malformed kidney. Initial attempts to avert surgery by pharmacologically reducing blood flow to the malformed kidney were unsuccessful. The review of the literature offers little evidence to support such a strategy.

Raina, Rupesh; Gulani, Vikas; Mehta, Lina; Jacobs, Gretta H.; Joyce, Kelly; Ponsky, Todd A.; Kenagy, David N.

2012-01-01

418

Residual Stresses in Oscillating Thoracic Arteries Reduce Circumferential Stresses and Stress Gradients  

E-print Network

REVISION Residual Stresses in Oscillating Thoracic Arteries Reduce Circumferential Stresses, Oscillations, Arteries, Atherosclerosis 1 #12; REVISION Residual Stresses in Oscillating Thoracic Arteries of residual stresses and strains in the oscillating arteries on the stress distribution in the vascular wall

Bukiet, Bruce

419

MAT2A mutations predispose individuals to thoracic aortic aneurysms.  

PubMed

Up to 20% of individuals who have thoracic aortic aneurysms or acute aortic dissections but who do not have syndromic features have a family history of thoracic aortic disease. Significant genetic heterogeneity is established for this familial condition. Whole-genome linkage analysis and exome sequencing of distant relatives from a large family with autosomal-dominant inheritance of thoracic aortic aneurysms variably associated with the bicuspid aortic valve was used for identification of additional genes predisposing individuals to this condition. A rare variant, c.1031A>C (p.Glu344Ala), was identified in MAT2A, which encodes methionine adenosyltransferase II alpha (MAT II?). This variant segregated with disease in the family, and Sanger sequencing of DNA from affected probands from unrelated families with thoracic aortic disease identified another MAT2A rare variant, c.1067G>A (p.Arg356His). Evidence that these variants predispose individuals to thoracic aortic aneurysms and dissections includes the following: there is a paucity of rare variants in MAT2A in the population; amino acids Glu344 and Arg356 are conserved from humans to zebrafish; and substitutions of these amino acids in MAT I? are found in individuals with hypermethioninemia. Structural analysis suggested that p.Glu344Ala and p.Arg356His disrupt MAT II? enzyme function. Knockdown of mat2aa in zebrafish via morpholino oligomers disrupted cardiovascular development. Co-transfected wild-type human MAT2A mRNA rescued defects of zebrafish cardiovascular development at significantly higher levels than mRNA edited to express either the Glu344 or Arg356 mutants, providing further evidence that the p.Glu344Ala and p.Arg356His substitutions impair MAT II? function. The data presented here support the conclusion that rare genetic variants in MAT2A predispose individuals to thoracic aortic disease. PMID:25557781

Guo, Dong-chuan; Gong, Limin; Regalado, Ellen S; Santos-Cortez, Regie L; Zhao, Ren; Cai, Bo; Veeraraghavan, Sudha; Prakash, Siddharth K; Johnson, Ralph J; Muilenburg, Ann; Willing, Marcia; Jondeau, Guillaume; Boileau, Catherine; Pannu, Hariyadarshi; Moran, Rocio; Debacker, Julie; Bamshad, Michael J; Shendure, Jay; Nickerson, Deborah A; Leal, Suzanne M; Raman, C S; Swindell, Eric C; Milewicz, Dianna M

2015-01-01

420

Strategies to treat thoracic aortitis and infected aortic grafts.  

PubMed

Infectious thoracic aortitis is a rare disease, especially since the incidence of syphilis and tuberculosis has dropped in western countries. However, the risk to develop an infectious aortitis and subsequent mycotic aneurysm formation is still present, particularly in case of associated endocarditis, sepsis, and in immunosuppressive disorders. Moreover, the number of surgical and endovascular thoracic aortic repairs is continuously increasing, and infective graft complications are observed more frequently. Several etiopathogenetic factors may play a role in thoracic aortic and prosthetic infections, including hematogenous seeding, local bacterial translocation, and iatrogenous contamination. Also, fistulization of the esophagus or the bronchial tree is commonly associated with these diseases, and it represents a critical event requiring a multidisciplinary management. Knowledge on underlying micro-organisms, antibiotic efficacy, risk factors, and prevention strategies has a key role in the management of this spectrum of infectious diseases involving the thoracic aorta. When the diagnosis of a mycotic aneurysm or a prosthetic graft infection is established, treatment is demanding, often including a number of surgical options. Patients are usually severely compromised by sepsis, and in most cases they are considered unfit for surgery for general clinical conditions or local concerns. Thus, results of different therapeutic strategies for infectious diseases of the thoracic aorta are still burdened with very high morbidity and mortality. In this manuscript, we review the literature regarding the main issues related to thoracic infectious aortitis and aortic graft infections, and we report our personal series of patients surgically treated at our institution for these conditions from 1993 to 2014. PMID:25608572

Kahlberg, A; Melissano, G; Tshomba, Y; Leopardi, M; Chiesa, R

2015-04-01

421

A review of the thoracic splanchnic nerves and celiac ganglia.  

PubMed

Anatomical variation of the thoracic splanchnic nerves is as diverse as any structure in the body. Thoracic splanchnic nerves are derived from medial branches of the lower seven thoracic sympathetic ganglia, with the greater splanchnic nerve comprising the more cranial contributions, the lesser the middle branches, and the least splanchnic nerve usually T11 and/or T12. Much of the early anatomical research of the thoracic splanchnic nerves revolved around elucidating the nerve root level contributing to each of these nerves. The celiac plexus is a major interchange for autonomic fibers, receiving many of the thoracic splanchnic nerve fibers as they course toward the organs of the abdomen. The location of the celiac ganglia are usually described in relation to surrounding structures, and also show variation in size and general morphology. Clinically, the thoracic splanchnic nerves and celiac ganglia play a major role in pain management for upper abdominal disorders, particularly chronic pancreatitis and pancreatic cancer. Splanchnicectomy has been a treatment option since Mallet-Guy became a major proponent of the procedure in the 1940s. Splanchnic nerve dissection and thermocoagulation are two common derivatives of splanchnicectomy that are commonly used today. Celiac plexus block is also a treatment option to compliment splanchnicectomy in pain management. Endoscopic ultrasonography (EUS)-guided celiac injection and percutaneous methods of celiac plexus block have been heavily studied and are two important methods used today. For both splanchnicectomies and celiac plexus block, the innovation of ultrasonographic imaging technology has improved efficacy and accuracy of these procedures and continues to make pain management for these diseases more successful. PMID:20235178

Loukas, Marios; Klaassen, Zachary; Merbs, William; Tubbs, R Shane; Gielecki, Jerzy; Zurada, Anna

2010-07-01

422

Prospective Evaluation of Thoracic Ultrasound in the Detection of Pneumothorax  

NASA Technical Reports Server (NTRS)

Introduction: Pneumothorax (PTX) occurs commonly in trauma patients and is confirmed by examination and radiography. Thoracic ultrasound (VIS) has been suggested as an alternative method for rapidly diagnosing PTX when X-ray is unavailable as in rural, military, or space flight settings; however, its accuracy and specificity are not known. Methods: We evaluated the accuracy of thoracic U/S detection of PTX compared to radiography in stable, emergency patients with a high suspicion of PTX at a Level-l trauma center over a 6-month period. Following University and NASA Institutional Review Board approval, informed consent was obtained from patients with penetrating or blunt chest trauma, or with a history consistent with PTX. Whenever possible, the presence or absence of the " lung sliding" sign or the "comet tail" artifact were determined by U/S in both hemithoraces by residents instructed in thoracic U/S before standard radiologic verification of PTX. Results were recorded on data sheets for comparison to standard radiography. Results: Thoracic VIS had a 94% sensitivity; two PTX could not be reliably diagnosed due to subcutaneous air; the true negative rate was 100%. In one patient, the VIS exam was positive while X ray did not confirm PTX; a follow-up film 1 hour later demonstrated a small PTX. The average time for bilateral thoracic VIS examination was 2 to 3 minutes. Conclusions: Thoracic ultrasound reliably diagnoses pneumothorax. Presence of the "lung sliding" sign conclusively excludes pneumothorax. Expansion of the FAST examination to include the thorax should be investigated.

Schwarz, K. W.; Hamilton, D. R.; Kirkpatrick, A. W.; Billica, R. D.; Williams, D. R.; Diebel, L. N.; Sargysan, A. E.; Dulchavsky, S. A.

2000-01-01

423

An unusual cause of dysphagia: thoracic aorta aneurysm.  

PubMed

The vascular structure related compression of esophagus is rather rare. Aberrant right subclavicular artery accounts for the majority of the rare entity, while the thoracic aorta aneurysm is a more dangerous type, called as dysphagia aortica. Delay in diagnosis and treatment of the dysphagia aortica predisposes to rupture and death. Herein, we reported a female patient with thoracic aorta aneurysm. A quick diagnosis by using chest contrast computed tomography (CT) scan and angiography of heart was made, and followed by emergent surgery. In the process, there was no delay on the diagnosis and treatment. The patient is going on well in the follow up. PMID:24416520

Wang, Wu-Ping; Yan, Xiao-Long; Ni, Yun-Feng; Zhang, Tao; Han, Yong; Li, Xiao-Fei; Lu, Qiang

2013-12-01

424

Renal artery stenosis in association with congenital anomalies of the kidney and urinary tract  

PubMed Central

Objectives: To describe 8 cases of renal artery stenosis (RAS) in children with congenital anomalies of the renal tract. Methods: We conducted a retrospective chart review of 78 children with RAS who were followed up at Great Ormond Street Hospital, London, United Kingdom between 2003 and 2012. We used an interventional radiology database to identify all patients who had RAS confirmed by digital subtraction angiography and examined all cases of congenital anomaly of the renal tract that had been diagnosed during childhood. Results: We documented the following renal anomalies: multicystic dysplastic kidney (n=2), renal hypoplasia (n=1), congenital solitary kidney with hydronephrosis (n=1), and unilateral vesicoureteric reflux with poorly functioning kidneys (n=2). The anomaly was unknown in 2 cases. Seven children had unilateral nephrectomy at a median age of 2.5 years (range, 0.4-10 years) for various urological abnormalities. All children were confirmed to have RAS after presentation with hypertension at a median age of 10 (3.5-16.2) years. Angioplasty was performed in 7 children, of which 6 achieved control of their blood pressure on reduced medications. Conclusion: We highlight the association between RAS and other renal anomalies, which indicates that they could share a common genetic background. PMID:25316474

Kari, Jameela A.; Roebuck, Derek J.; Tullus, Kjell

2014-01-01

425

Radionuclide determination of individual kidney function in the treatment of chronic renal obstruction  

SciTech Connect

Differential radionuclide renal scans can be useful in the management of patients with chronic partial obstruction of 1 kidney. The /sup 99m/Tc diethylenetriaminepentaacetic acid perfusion scan can be used to assess glomerular blood flow. The /sup 131/I orthoiodohippurate renal scan provides qualitative functional information from scintigrams and quantitative evaluation of effective renal plasma flow to each kidney, as well as a total excretory index. Sequential /sup 99m/Tc diethylenetriaminepentaacetic acid and /sup 131/I orthoiodohippurate renal scans were used to assess individual renal function before and after surgical correction of unilateral chronic renal obstruction in 31 patients. The preservation of cortical perfusion on /supb 99m/Tc diethylenetriaminepentaacetic acid scans indicated that potential existed for partial recovery of renal function. Effective renal plasma flow and excretory index determined in conjunction with the /sup 131/I orthoiodohippurate scans provided a quantitative assessment of preoperative renal function, an evaluation of the effect of surgery and a sensitive method for long-term evaluation of differential renal function. Correction of ureteropelvic junction obstruction usually resulted in improvement in unilateral renal function. Neither nephrolithotomy nor extended pyelolithotomy diminished renal function in the kidney subjected to an operation and often improved it. Patients with long-standing distal ureteral obstruction had the least improvement in renal function postoperatively.

Belis, J.A.; Belis, T.E.; Lai, J.C.; Goodwin, C.A.; Gabriele, O.F.

1982-04-01

426

Electrophysiological and Morphological Characterization of Propriospinal Interneurons in the Thoracic Spinal Cord  

PubMed Central

Propriospinal interneurons in the thoracic spinal cord have vital roles not only in controlling respiratory and trunk muscles, but also in providing possible substrates for recovery from spinal cord injury. Intracellular recordings were made from such interneurons in anesthetized cats under neuromuscular blockade and with the respiratory drive stimulated by inhaled CO2. The majority of the interneurons were shown by antidromic activation to have axons descending for at least two to four segments, mostly contralateral to the soma. In all, 81% of the neurons showed postsynaptic potentials (PSPs) to stimulation of intercostal or dorsal ramus nerves of the same segment for low-threshold (?5T) afferents. A monosynaptic component was present for the majority of the peripherally evoked excitatory PSPs. A central respiratory drive potential was present in most of the recordings, usually of small amplitude. Neurons depolarized in either inspiration or expiration, sometimes variably. The morphology of 17 of the interneurons and/or of their axons was studied following intracellular injection of Neurobiotin; 14 axons were descending, 6 with an additional ascending branch, and 3 were ascending (perhaps actually representing ascending tract cells); 15 axons were crossed, 2 ipsilateral, none bilateral. Collaterals were identified for 13 axons, showing exclusively unilateral projections. The collaterals were widely spaced and their terminations showed a variety of restricted locations in the ventral horn or intermediate area. Despite heterogeneity in detail, both physiological and morphological, which suggests heterogeneity of function, the projections mostly fitted a consistent general pattern: crossed axons, with locally weak, but widely distributed terminations. PMID:21106900

Saywell, S. A.; Ford, T. W.; Meehan, C. F.; Todd, A. J.

2011-01-01

427

[The system problems related to thoracic surgery practices in japan; message from the Japanese association for thoracic surgery].  

PubMed

The thoracic surgery practice in Japan has characteristics such as strong burden to surgeons and young trainees for high-risk procedures under poor health care manpower system and less qualification for their high-level practices. The presence of too many numbers of certified surgeons and teaching hospitals for cardiac, general thoracic and esophageal surgeries has been well recognized providing low quality maintenance and poor training system. The Japanese Association for Thoracic Surgery has recently made a step towards to open the data of hospital quality promoting the discussion to reunify the hospitals and surgeons into reasonable numbers to respond to the social demand. The new 2-year postgraduate clinical training and also a new specialty medical board approval for advertisement have provided various problems and controversies, and we must make efforts to overcome these problems by providing new strategies to make our practices more qualified. PMID:17515081

Matsuda, Hikaru

2007-05-01

428

Thoracic CT-PET Registration Using a 3D Breathing Model  

E-print Network

Thoracic CT-PET Registration Using a 3D Breathing Model Antonio Moreno1 , Sylvie Chambon1 , Anand P Orlando, USA Abstract. In the context of thoracic CT-PET volume registration, we present a novel method applications. We consider Computed Tomography (CT) and Positron Emission Tomography (PET) in thoracic regions

Paris-Sud XI, Université de

429

A normalized thoracic coordinate system for atlas mapping in 3D CT images  

Microsoft Academic Search

In this paper, a normalized thoracic coordinate system (NTCS) is defined for rapidly mapping the 4D thoracic organ atlas into individual CT volume images. This coordinate system is defined based on the thoracic skeleton. The coordinate values are normalized by the size of the individual thorax so that this coordinate system is universal to different individuals. For compensating the respiratory

Hongkai Wang; Jing Bai; Yonghong Zhang

2008-01-01

430

Magnetic resonance imaging of the thoracic spine Part 2: common disorders  

Microsoft Academic Search

This article provides an overview for the identification of thoracic spinal pathologies on magnetic resonance imaging (MRI) for the chiropractor. Illustrative examples are given, with discussion, of commonly encountered disorders including thoracic disc lesions, hemangioma, syrinx formation, Scheuermann's disease and compression fracture. Normal MRI appearance of the thoracic spine—this was approached in part 1 of the article.

Renee M. DeVries; Michelle A. Wessely

2005-01-01

431

Kidney Cell Electrophoresis  

NASA Technical Reports Server (NTRS)

Materials and procedures for microgravity electrophoresis of living human embryonic kidney cells were evaluated, ground support in the form of analytical cell electrophoresis and flow cytometry was provided and cells returned from space flight were analyzed. Preflight culture media, electrophoresis buffer, fraction collection media, temperature profiles, and urokinase assay procedures were tested prior to flight. Electrophoretic mobility distributions of aliquots of the cell population to be fractionated in flight were obtained. The protocol established and utilized is given.

Todd, P.

1985-01-01

432

Polycystic Kidney Disease  

Microsoft Academic Search

\\u000a A 42-year-old woman presented for additional evaluation of autosomal dominant polycystic kidney disease (ADPKD). She was initially\\u000a diagnosed with ADPKD at age 36 after developing fever and flank pain. At that time, ultrasonography showed bilateral renal\\u000a cysts, and liver and ovarian cysts. The serum creatinine level was normal. Hypertension was diagnosed at the age of 32 years\\u000a and has since

Ying-Cai Tan; Jon Blumenfeld; Hanna Rennert

433

Polycystic kidney disease.  

PubMed

This autosomal dominant disorder usually appears in middle life. The most common findings are proteinuria, abdominal pain and palpable kidneys, followed by hematuria, hypertension, pyuria, uremia and calculi. In 15% of patients, death is due to cerebral aneurysm. Family counseling and the detection of "at risk" family members are important elements of management. Statistically, half of the offspring of one affected parent will have the disease. PMID:930806

Chester, A C; Harris, J P; Schreiner, G E

1977-12-01

434

Claudins and the kidney.  

PubMed

Claudins are tight-junction membrane proteins that function as both pores and barriers in the paracellular pathway in epithelial cells. In the kidney, claudins determine the permeability and selectivity of different nephron segments along the renal tubule. In the proximal tubule, claudins have a role in the bulk reabsorption of salt and water. In the thick ascending limb, claudins are important for the reabsorption of calcium and magnesium and are tightly regulated by the calcium-sensing receptor. In the distal nephron, claudins need to form cation barriers and chloride pores to facilitate electrogenic sodium reabsorption and potassium and acid secretion. Aldosterone and the with-no-lysine (WNK) proteins likely regulate claudins to fine-tune distal nephron salt transport. Genetic mutations in claudin-16 and -19 cause familial hypomagnesemic hypercalciuria with nephrocalcinosis, whereas polymorphisms in claudin-14 are associated with kidney stone risk. It is likely that additional roles for claudins in the pathogenesis of other types of kidney diseases have yet to be uncovered. PMID:24948743

Yu, Alan S L

2015-01-01

435

Kidney stones during pregnancy.  

PubMed

Kidney stones affect 10% of people at some point in their lives and, for some unfortunate women, this happens during pregnancy. Pregnancy is a complex state and both physiological and mechanical changes alter risk factors for kidney stone formation. When a pregnant woman develops acute nephrolithiasis, the situation is more complicated than in nonpregnant women. Imaging limitations and treatment restrictions mean that special diagnostic and management algorithms are needed upon presentation. Ultrasonography remains the gold-standard first-line diagnostic imaging modality for kidney stones during pregnancy but several second-line alternatives exist. Acute renal colic during pregnancy is associated with risks to both mother and fetus. As such, these patients need to be handled with special attention. First-line management is generally conservative (trial of passage and pain management) and is associated with a high rate of stone passage. Presentation of obstructive nephrolithiasis with associated infection represents a unique and serious clinical situation requiring immediate drainage. If infection is not present and conservative management fails, ureteroscopy can be offered if clinically appropriate, but, in some circumstances, temporary drainage with ureteral stent or nephrostomy tube might be indicated. Shockwave lithotripsy and percutaneous nephrolithotomy are contraindicated during pregnancy. PMID:24515090

Semins, Michelle J; Matlaga, Brian R

2014-03-01

436

Acute kidney injury  

PubMed Central

Abstract: Acute kidney injury is a frequent and serious complication in hospitalized patients. Mortality rates have not substantially been decreased during the last 20 years. In most patients AKI results from transient renal hypoperfusion or ischemia. The consequences include tubular cell dysfunction/damage, inflammation of the organ, and post-ischemic microvasculopathy. The two latter events perpetuate kidney damage in AKI. Clinical manifestations result from diminished excretion of water, electrolytes, and endogenous / exogenous waste products. Patients are endangered by cardiovascular complications such as hypertension, heart failure, and arrhythmia. In addition, the whole organism may be affected by systemic toxification (uremia). The diagnostic approach in AKI involves several steps with renal biopsy inevitable in some patients. The current therapy focuses on preventing further kidney damage and on treatment of complications. Different pharmacological strategies have failed to significantly improve prognosis in AKI. If dialysis treatment becomes mandatory, intermittent and continuous renal replacement therapies are equally effective. Thus, new therapies are urgently needed in order to reduce short- and long-term outcome in AKI. In this respect, stem cell-based regimens may offer promising perspectives. PMID:25618438

Müller, Gerhard Anton

2015-01-01

437

Unilateral Stance Strategies of Athletes With ACL Deficiency  

PubMed Central

Aberrant movement strategies are characteristic of ACL-deficient athletes with recurrent knee instability (non-copers), and may instigate premature or accelerate joint degradation. Biomechanical evaluation of kinematic changes over time may elucidate noncopers’ responses to neuromuscular intervention and ACL reconstruction (ACLR). Forty noncopers were randomized into a perturbation group or a strength training only group. We evaluated the effects of perturbation training, and then gender on knee angle and tibial position during a unilateral standing task before and after ACLR. No statistically significant interactions were found. Before surgery, the strength training only group demonstrated knee angle asymmetry, but 6 months after ACLR, both groups presented with similar knee flexion between limbs. Aberrant and asymmetrical tibial position was found only in females following injury and ACLR. Neither treatment group showed distinct unilateral standing strategies following intervention; however, males and female noncopers appear to respond uniquely to physical therapy and surgery. PMID:22983931

Di Stasi, Stephanie L.; Hartigan, Erin H.; Snyder-Mackler, Lynn

2013-01-01

438

Miniaturized bronchoscopy enables unilateral investigation, application, and sampling in mice.  

PubMed

Lung diseases, including pneumonia and asthma, are among the most prevalent human disorders, and murine models have been established to investigate their pathobiology and develop novel treatment approaches. Whereas bronchoscopy is valuable for diagnostic and therapeutic procedures in patients, no equivalent for small rodents has been established. Here, we introduce a miniaturized video-bronchoscopy system offering new opportunities in experimental lung research. With an outer diameter of 0.75 mm, it is possible to advance the optics into the main bronchi of mice. An irrigation channel allows bronchoalveolar lavage and unilateral application of substances to one lung. Even a unilateral infection is possible, enabling researchers to use the contralateral lung as internal control. PMID:24960575

Dames, Claudia; Akyüz, Levent; Reppe, Katrin; Tabeling, Christoph; Dietert, Kristina; Kershaw, Olivia; Gruber, Achim D; Meisel, Christian; Meisel, Andreas; Witzenrath, Martin; Engel, Odilo

2014-12-01

439

Global suppression of electrocortical activity in unilateral perinatal thalamic stroke.  

PubMed

We present an unusual case of persistent generalized electroencephalography (EEG) suppression and right-sided clonic seizures in a male infant born at 40(+2) weeks' gestation, birthweight 3240g, with an isolated unilateral thalamic stroke. The EEG at 13 hours after birth showed a generalized very low amplitude background pattern, which progressed to frequent electrographic seizures over the left hemisphere. The interictal background EEG pattern remained grossly abnormal over the next 48 hours, showing very low background amplitudes (<10?V). Magnetic resonance imaging revealed an isolated acute left-sided thalamic infarction. This is the first description of severe global EEG suppression caused by an isolated unilateral thalamic stroke and supports the role of the thalamus as the control centre for cortical electrical activity. PMID:24410068

Kharoshankaya, Liudmila; Filan, Peter M; Bogue, Conor O; Murray, Deirdre M; Boylan, Geraldine B

2014-07-01

440

Contralateral flow reduction in unilateral stroke: evidence for transhemispheric diaschisis  

SciTech Connect

Using clinical presentation, angiography, computed tomography, and nuclear magnetic resonance imaging, 7 patients were identified who had strictly unilateral hemispheric infarction and unilateral cerebrovascular disease. In 6, cerebral blood flow measured by fluorine-18-fluoromethane inhalation and positron emission tomography was reduced in the contralateral hemisphere (p less than 0.05). Multiple regression analysis demonstrated a high correlation between contralateral flow reduction and the degree of flow impairment in the infarcted area (r = 0.941, p = 0.0014) but not with age, risk factor profile, blood pressure, PCO/sub 2/, hematocrit, or duration of stroke. We conclude that transhemispheric diaschisis best explains the contralateral flow reduction seen in supratentorial ischemic stroke.

Lagreze, H.L.; Levine, R.L.; Pedula, K.L.; Nickles, R.J.; Sunderland, J.S.; Rowe, B.R.

1987-09-01

441

Unilateral Loss of Spontaneous Venous Pulsations in an Astronaut  

NASA Technical Reports Server (NTRS)

Spontaneous venous pulsations seen on the optic nerve head (optic disc) are presumed to be caused by fluctuations in the pressure gradient between the intraocular and retrolaminar venous systems. The disappearance of previously documented spontaneous venous pulsations is a well-recognized clinical sign usually associated with a rise in intracranial pressure and a concomitant bilateral elevation of pressure in the subarachnoid space surrounding the optic nerves. In this correspondence we report the unilateral loss of spontaneous venous pulsations in an astronaut 5 months into a long duration space flight. We documented a normal lumbar puncture opening pressure 8 days post mission. The spontaneous venous pulsations were also documented to be absent 21 months following return to Earth.. We hypothesize that these changes may have resulted from a chronic unilateral rise in optic nerve sheath pressure caused by a microgravity-induced optic nerve sheath compartment syndrome.

Mader, Thomas H.; Gibson, C. Robert; Lee, Andrew G.; Patel, Nimesh; Hart, Steven; Pettit, Donald R.

2014-01-01

442

Secondary bilateral synchrony in unilateral pial angiomatosis: successful surgical treatment.  

PubMed Central

Three children with circumscribed unilateral pial angiomatosis had both generalised and partial seizures associated with bilateral synchronous spike-wave complexes. Dramatic control of the seizures was obtained by surgical removal restricted to the angiomas and underlying cortex. There was recurrence of seizures in one patient from whom only one of two angiomatous areas was removed but not in the two patients whose excision was total. These cases indicate that secondary bilateral synchrony can occur with lesions of the posterior and external parts of one hemisphere. Surgical removal of a definable lesion, without intracranial recording, can help patients with intractable epilepsy due to unilateral pial angiomatosis, even in the presence of wide diffusion of clinical and electroencephalographic abnormalities. PMID:3136229

Chevrie, J J; Specola, N; Aicardi, J

1988-01-01

443

Akt1-mediated fast/glycolytic skeletal muscle growth attenuates renal damage in experimental kidney disease.  

PubMed

Muscle wasting is frequently observed in patients with kidney disease, and low muscle strength is associated with poor outcomes in these patients. However, little is known about the effects of skeletal muscle growth per se on kidney diseases. In this study, we utilized a skeletal muscle-specific, inducible Akt1 transgenic (Akt1 TG) mouse model that promotes the growth of functional skeletal muscle independent of exercise to investigate the effects of muscle growth on kidney diseases. Seven days after Akt1 activation in skeletal muscle, renal injury was induced by unilateral ureteral obstruction (UUO) in Akt1 TG and wild-type (WT) control mice. The expression of atrogin-1, an atrophy-inducing gene in skeletal muscle, was upregulated 7 days after UUO in WT mice but not in Akt1 TG mice. UUO-induced renal interstitial fibrosis, tubular injury, apoptosis, and increased expression of inflammatory, fibrosis-related, and adhesion molecule genes were significantly diminished in Akt1 TG mice compared with WT mice. An increase in the activating phosphorylation of eNOS in the kidney accompanied the attenuation of renal damage by myogenic Akt1 activation. Treatment with the NOS inhibitor L-NAME abolished the protective effect of skeletal muscle Akt activation on obstructive kidney disease. In conclusion, Akt1-mediated muscle growth reduces renal damage in a model of obstructive kidney disease. This improvement appears to be mediated by an increase in eNOS signaling in the kidney. Our data support the concept that loss of muscle mass during kidney disease can contribute to renal failure, and maintaining muscle mass may improve clinical outcome. PMID:25012168

Hanatani, Shinsuke; Izumiya, Yasuhiro; Araki, Satoshi; Rokutanda, Taku; Kimura, Yuichi; Walsh, Kenneth; Ogawa, Hisao

2014-12-01

444

Four miniature kidneys: supernumerary kidney and multiple organ system anomalies.  

PubMed

More than 350 years after Martius's first reported case in 1656, supernumerary kidney (SNK) continues to fascinate the world of medicine, generating new ideas in the domain of embryogenesis. Association of a normal kidney with a second or third ipsilateral smaller kidney is an extremely rare anomaly with only a total of 81 cases reported until today. We are reporting a case of SNK, clinically diagnosed as right hydronephrosis, associated with an ipsilateral ectopic ureter, a contralateral partially duplicated ureter, and a multiseptate gallbladder. Pathologic examination of the nephrectomy revealed 4 miniature kidneys, joining a dilated ureter through 4 separate conduits. Our patient is the first reported case of SNK with absent ipsilateral normal kidney, presence of more than 3 kidneys on 1 side, and associated anomaly in the gallbladder. This case represents a unique combination of rarities, suggesting insights in the domain of molecular embryology. PMID:24593866

Afrouzian, Marjan; Sonstein, Joseph; Dadfarnia, Tahereh; Sreshta, J Nicholas; Hawkins, Hal K

2014-05-01

445

Unilateral incompatibility: hypotheses, debate and its implications for plant breeding  

Microsoft Academic Search

Unilateral incompatibility, its evolution and the hypotheses put forward to explain this phenomenon have been discussed. A new hypothesis is presented giving an easy explanation of the problems arisen and of the results obtained hitherto. The results to be expected from crosses between self-compatible and self-incompatible species and the crossability and (in)compatibility behaviour of their hybrids and segregating generations are

M. M. F. Abdalla

1972-01-01

446

Bilateral tremor responses to unilateral loading and fatiguing muscle contractions.  

PubMed

Although physiological tremor has been extensively studied within a single limb, tremor relationships between limbs are not well understood. Early investigations proposed that tremor in each limb is driven by CNS oscillators operating in parallel. However, recent evidence suggests that tremor in both limbs arises from shared neural inputs and is more likely to be observed under perturbed conditions. In the present study, postural tremor about the elbow joint and elbow flexor EMG activity were examined on both sides of the body in response to unilateral loading and fatiguing muscle contractions. Applying loads of 0.5, 1.0, 1.5, and 3.0 kg to a single limb increased tremor and muscle activity in the loaded limb but did not affect the unloaded limb, indicating that manipulating the inertial characteristics of a limb does not evoke bilateral tremor responses. In contrast, maximal-effort unilateral isometric contractions resulted in increased tremor and muscle activity in both the active limb and the nonactive limb without any changes in between-limb tremor or muscle coupling. When unilateral contractions were repeated intermittently, to the extent that maximum torque generation about the elbow joint declined by 50%, different tremor profiles were observed in each limb. Specifically, unilateral fatigue altered coupling between limbs and generated a bilateral response such that tremor and brachioradialis EMG decreased for the fatigued limb and increased in the contralateral nonfatigued limb. Our results demonstrate that activity in the nonactive limb may be due to a "spillover" effect rather than directly coupled neural output to both arms and that between-limb coupling for tremor and muscle activity is only altered under considerably perturbed conditions, such as fatigue-inducing contractions. PMID:23636728

Kavanagh, Justin J; Cresswell, Andrew G; Sabapathy, Surendran; Carroll, Timothy J

2013-07-01

447

Beware of "curare cleft" like changes during unilateral capnothorax.  

PubMed

Capnography is a standard monitoring tool during general anaesthesia. Diaphragmatic movement with the weaning of muscle relaxant effect produces the characteristic "curare cleft" on capnography. Various artefacts can mimick this trace intraoperatively. Cautious interpretation and identification of these is essential to avoid any undue overdosing of the patients with muscle relaxants. We report "curare cleft" like artefact during ventilation with a single lumen tube in a patient with unilateral capnothorax undergoing minimally invasive esophagectomy. PMID:24132805

Singh, Manila; Chaudhary, Kapil; Uppal, Rajeev; Jain, Sachin

2014-06-01

448

Prosthesis rejection in children with a unilateral congenital arm defect  

Microsoft Academic Search

Objective: To determine the rate of rejection for prosthetic use in children and to investigate reasons for this rejection.Design: Cross-sectional study of a cohort of children.Setting: Rehabilitation centre, St Maartenskliniek, Nijmegen, the Netherlands.Subjects: Thirty-two children (0–18 years) with a unilateral congenital arm defect who visited the clinic between September 1991 and December 1996.Methods: Parents of all children and 19 children

K Postema; V van der Donk; J van Limbeek; R AJ Rijken; M J Poelma

1999-01-01

449

Transient electro-oculogram impairment in unilateral acute idiopathic maculopathy  

Microsoft Academic Search

Unilateral acute idiopathic maculopathy (UAIM) is a rare distinct entity characterized by acute exudative maculopathy occurring\\u000a in young persons. The purpose of this case study is to report transient electro-oculogram (EOG) impairment during the acute\\u000a stage of UAIM. A 16-year-old healthy female with UAIM in the left eye underwent serial visual field, fluorescein angiography,\\u000a indocyanine green angiography, full-field electroretinogram (ERG),

Byron L. Lam; Pedro F. Lopez; Sander R. Dubovy; Mu Liu

2009-01-01

450

Therapeutic Effect of Retinoic Acid on Unilateral Ureteral Obstruction Model  

Microsoft Academic Search

Background: Retinoic acids, a group of natural and synthetic vitamin A derivatives, have potent anti-proliferative, anti-inflammatory and anti-fibrotic properties. We investigated the therapeutic effect of all-trans-retinoic acid (ATRA) on unilateral ureteral obstruction (UUO) model mice. Methods: First, to evaluate the prophylactic effect, we administered 0.5 mg of ATRA for 3 days before UUO (UUO ATRA). Then, to evaluate the therapeutic

Kazuya Kishimoto; Koji Kinoshita; Shoichi Hino; Tomohiro Yano; Yasuaki Nagare; Hideki Shimazu; Yuji Nozaki; Masafumi Sugiyama; Shinya Ikoma; Masanori Funauchi

2011-01-01

451

Magnetic Vestibular Stimulation in Subjects with Unilateral Labyrinthine Disorders  

PubMed Central

We recently discovered that static magnetic fields from high-strength MRI machines induce nystagmus in all normal humans, and that a magneto-hydrodynamic Lorentz force, derived from ionic currents in the endolymph and pushing on the cupula, best explains this effect. Individuals with no labyrinthine function have no nystagmus. The influence of magnetic vestibular stimulation (MVS) in individuals with unilateral deficits in labyrinthine function is unknown and may provide insight into the mechanism of MVS. These individuals should experience MVS, but with a different pattern of nystagmus consistent with their unilateral deficit in labyrinthine function. We recorded eye movements in the static magnetic field of a 7 T MRI machine in nine individuals with unilateral labyrinthine hypofunction, as determined by head impulse testing and vestibular-evoked myogenic potentials (VEMP). Eye movements were recorded using infrared video-oculography. Static head positions were varied in pitch with the body supine, and slow-phase eye velocity (SPV) was assessed. All subjects exhibited predominantly horizontal nystagmus after entering the magnet head-first, lying supine. The SPV direction reversed when entering feet-first. Pitching chin-to-chest caused subjects to reach a null point for horizontal SPV. Right unilateral vestibular hypofunction (UVH) subjects developed slow-phase-up nystagmus and left UVH subjects, slow-phase-down nystagmus. Vertical and torsional components were consistent with superior semicircular canal excitation or inhibition, respectively, of the intact ear. These findings provide compelling support for the hypothesis that MVS is a result of a Lorentz force and suggest that the function of individual structures within the labyrinth can be assessed with MVS. As a novel method of comfortable and sustained labyrinthine stimulation, MVS can provide new insights into vestibular physiology and pathophysiology. PMID:24659983

Ward, Bryan K.; Roberts, Dale C.; Della Santina, Charles C.; Carey, John P.; Zee, David S.

2014-01-01

452

Magnetic vestibular stimulation in subjects with unilateral labyrinthine disorders.  

PubMed

We recently discovered that static magnetic fields from high-strength MRI machines induce nystagmus in all normal humans, and that a magneto-hydrodynamic Lorentz force, derived from ionic currents in the endolymph and pushing on the cupula, best explains this effect. Individuals with no labyrinthine function have no nystagmus. The influence of magnetic vestibular stimulation (MVS) in individuals with unilateral deficits in labyrinthine function is unknown and may provide insight into the mechanism of MVS. These individuals should experience MVS, but with a different pattern of nystagmus consistent with their unilateral deficit in labyrinthine function. We recorded eye movements in the static magnetic field of a 7 T MRI machine in nine individuals with unilateral labyrinthine hypofunction, as determined by head impulse testing and vestibular-evoked myogenic potentials (VEMP). Eye movements were recorded using infrared video-oculography. Static head positions were varied in pitch with the body supine, and slow-phase eye velocity (SPV) was assessed. All subjects exhibited predominantly horizontal nystagmus after entering the magnet head-first, lying supine. The SPV direction reversed when entering feet-first. Pitching chin-to-chest caused subjects to reach a null point for horizontal SPV. Right unilateral vestibular hypofunction (UVH) subjects developed slow-phase-up nystagmus and left UVH subjects, slow-phase-down nystagmus. Vertical and torsional components were consistent with superior semicircular canal excitation or inhibition, respectively, of the intact ear. These findings provide compelling support for the hypothesis that MVS is a result of a Lorentz force and suggest that the function of individual structures within the labyrinth can be assessed with MVS. As a novel method of comfortable and sustained labyrinthine stimulation, MVS can provide new insights into vestibular physiology and pathophysiology. PMID:24659983

Ward, Bryan K; Roberts, Dale C; Della Santina, Charles C; Carey, John P; Zee, David S

2014-01-01

453

Human Gait and Postural Control after Unilateral Total Knee Arthroplasty  

PubMed Central

Introduction: This study assesses the changes in human gait in the early postoperative phase of unilateral TKA, by evaluating the variability of free moment. Materials and method: The study group consisted of 10 patients from the Orthopedic Department of the 'Elias' University Hospital in Bucharest who undergone unilateral knee arthroplasty with the same type of posterior cruciate ligament substituting prosthesis. For the evaluation of free moment an AMTI AccuGait force platform was used. Results: Regarding the free moment peaks, for the operated and non-operated limb, increased significantly (p <0.05) in the postoperative period. The stance time was higher post-surgery for both limbs. Discussion: In the early postoperative phase of unilateral TKA, free moment is higher on both the operated and the non-operated limbs, which means that the knees are subjected to higher torques. Shortly after TKA, patients tend to walk with lower speed, with small steps and reduced cadence. Stance time differences between the operated and the non-operated limbs can lead to overuse of the latter, worsening its condition. Conclusions: It is highly important to adopt a well-managed rehabilitation program in order to increase walking stability. The cost effectiveness of this procedure could be highly dependent on the rehab program. The parameters studied in this article are useful in assessing the rehabilitation protocol. PMID:25705305

STAN, Gabriel; ORBAN, Horia

2014-01-01

454

Ovarian Reserve After Laparoscopic Treatment of Unilateral Ovarian Endometrioma  

PubMed Central

Aim: To evaluate the effect of laparoscopic treatment of unilateral ovarian endometrioma on ovarian reserve using ultrasonographic markers, ovarian volume and antral follicle count (AFC), and two biochemical markers, serum levels of Follicle-stimulating hormone (FSH) and Estradiol (E2). Material and methods: This prospective study included 40 patients in their reproductive age, between 18 and 40 years old. They were treated laparoscopically for unilateral ovarian endometrioma. Markers of ovarian reserve were investigated before and three months after surgery. Transvaginal ultrasound examination was used for measurement of ovarian volume and AFC. Biochemical markers (FSH and E2 levels) were determined by chemiluminescent tests. Results: Ovarian volume was significantly reduced after surgery. There was significant increase of AFC and non-significant increase of E2 levels in treated patients after three months. Conclusions: Laparoscopic cystectomy of unilateral ovarian endometrioma decreased ovarian reserve immediately after surgery with decrease of ovarian volume. But ovarian reserve was increased after three months with increase of AFC and estradiol levels. PMID:25684843

Georgievska, Jadranka; Sapunov, Slavejko; Cekovska, Svetlana; Vasilevska, Kristin

2014-01-01

455

Evaluation of mandibular condyles in children with unilateral posterior crossbite.  

PubMed

The relationship of mandibular condyle dimensions and its association with unilateral posterior crossbite (UPXB) has been suggested in the literature. The purpose of this prospective study was to evaluate mandibular condyles on the left and right sides and between crossed and non-crossed sides in the sagittal and coronal planes, using cone-beam computed tomography (CBCT). Twenty CBCT images of 40 temporo mandibular joints (TMJs) in individuals in mixed dentition phase, which included 9 males (mean 7.9 years) and 11 females (mean 8.2 years), with unilateral posterior crossbite without premature contacts and functional mandibular shifts and with transverse maxillary deficiency. The criteria for sample exclusion included the presence of painful symptoms, facial trauma history, systemic diseases such as juvenile rheumatoid arthritis, mouth opening limitation (< 40 mm), congenital or genetic anomalies, and skeletal asymmetries that may result in TMJ disorders. Dimensional measurements of the condyles between the right and left sides and crossed and non-crossed sides in sagittal and coronal view were made. There was no significant difference between the measurements of the crossed and non-crossed sides in both sagittal and coronal view. These findings suggest that the presence of unilateral posterior crossbite in children with UPXB did not result in changes between the mandibular condyles in the right and left sides or between the crossed and non-crossed sides in the coronal or sagittal plane. PMID:25760067

Illipronti-Filho, Edson; Fantini, Solange Mongelli; Chilvarquer, Israel

2015-03-01

456

Thoracic aortic dissection in a 38-year-old man.  

PubMed

A few days before Christmas, a flight team was activated for an interfacility transfer of a 38-year-old man with a history of hypertension and spinal stenosis diagnosed with a thoracic aortic dissection. The patient was presented to a local community hospital complaining of nearly 5 days of left-sided rib pain. This afternoon when he stood up from a chair, he experienced a near-syncopal episode. Concurrently, he had an abrupt onset of a tearing sensation in his chest that radiated to thoracic spine in the region between his shoulder blades. Ground emergency medical services (EMS) was called, and the patient was transported to the community hospital. During the initial transport and evaluation by the emergency department (ED) staff, the patient was noted to be hypertensive, with a systolic blood pressure greater than 180 mmHg. In the ED, the patient received aspirin, morphine, and Lopressor. He underwent a chest x-ray (Figure 1) and computed tomography (CT) scan and was diagnosed with a type B thoracic aorta dissection, which was noted to start on the descending thoracic aorta distal to the left subclavian artery and extend to the level of the celiac trunk (Figure 2). Despite the initial beta blockade, the patient was noted to be profoundly hypertensive, with initial blood pressure greater than 190 mmHg systolic. The flight team was activated for hemodynamic management and rapid transport to a facility capable of vascular and cardiothoracic surgery. PMID:20599144

Tilney, Peter

2010-01-01

457

Intercostal misplacement of a thoracic epidural catheter -A case report-  

PubMed Central

Epidural block is useful for chronic pain and thoracic surgery. However, there are several complications, which include vessels or dural puncture, pleural puncture, misplacement of epidural catheter and trauma to the spinal cord. We report a case of intercostal misplacement of an epidural catheter in a 66-year-old patient who scheduled for left thoracotomy. PMID:21179298

Kim, Young Bae

2010-01-01

458

Follow-up results after resection of thoracic esophageal carcinoma  

Microsoft Academic Search

During the past 14.5 years, we have treated 430 patients with carcinoma of the thoracic esophagus. The resection rate was 72% and the overall operative mortality rate was 16%. During the past 5 years, the operative mortality rate has been markedly reduced to 4.5%. The low operative mortality rate in recent years is the result of selection of the operative

Morio Kasai; Shozo Mori; Toshio Watanabe

1978-01-01

459

Segmental vitiligo in a patient with thoracic outlet syndrome.  

PubMed

Reported here is a 35-year-old man with findings of thoracic outlet syndrome and bilateral segmental vitiligo on C8-T1 dermatomes. The possible causal relationship between the two disorders under the common denominator of cervical sympathetic involvement is discussed for the first time in the literature. PMID:21800114

Kara, Murat; Y?lmaz, Sinan; Kara, Özgür; ?enol, Mehmet Güney; Özda?, Fatih; Özçakar, Levent

2012-09-01

460

Thoracic Vertebral Actinomycosis: Actinomyces israelii and Fusobacterium nucleatum?  

PubMed Central

Actinomyces spp. are considered rare pathogens in today's medicine, especially with thoracic vertebral involvement. Classic actinomycosis (50%) presents as an oral-cervicofacial (“lumpy jaw”) infection. This report describes a case of spinal cord compression caused by Actinomyces israelii with the coisolation of Fusobacterium nucleatum. There are limited numbers of similar cases. PMID:18337385

Honda, Hitoshi; Bankowski, Matthew J.; Kajioka, Eric H. N.; Chokrungvaranon, Nalurporn; Kim, Wesley; Gallacher, Scott T.

2008-01-01

461

Two internal thoracic artery grafts are better than one  

Microsoft Academic Search

Objective: Does the use of bilateral internal thoracic artery (ITA) grafts provide incremental benefit relative to the use of a single ITA graft? Methods: We conducted a retrospective, nonrandomized, long-term (mean follow-up interval of 10 postoperative years) study of patients undergoing elective primary isolated coronary bypass surgery who received either single (8123 patients) or bilateral ITA grafts (2001 patients), with

Bruce W. Lytle; Eugene H. Blackstone; Floyd D. Loop; Penny L. Houghtaling; John H. Arnold; Rami Akhrass; Patrick M. McCarthy; Delos M. Cosgrove

1999-01-01

462

Xanthorrhizol induces endothelium-independent relaxation of rat thoracic aorta.  

PubMed

Xanthorrhizol, a bisabolene isolated from the medicinal plant Iostephane heterophylla, was assayed on rat thoracic aorta rings to elucidate its effect and likely mechanism of action, by measuring changes of isometric tension. Xanthorrhizol (1, 3, 10, 30 and 100 microg/mL) significantly inhibited precontractions induced by KCI-; (60mM), noradrenaline (10(-6) M) or CaCl2 (1.0 mM). Increasing concentrations of external calcium antagonized the inhibitory effect on KCl-induced contractions. The vasorelaxing effect of xanthorrhizol was not affected by indomethacin (10 microM) or L-NAME (100 microM) in intact rat thoracic aorta rings precontracted by noradrenaline, which suggested that the effect was not mediated through either endothelium-derived prostacyclin (PGI2) or nitric oxide release from endothelial cells. Endothelium removal did not affect the relaxation induced by xanthorrhizol on rat thoracic aorta rings, discarding the participation of any substance released by the endothelium. Xanthorrhizol inhibitory effect was greater on KCI- and CaCl2-induced contractions than on those induced by noradrenaline. Xanthorrhizol inhibitory effect in rat thoracic aorta is likely explained for interference with calcium availability by inhibiting calcium influx through both voltage- and receptor-operated channels. PMID:10983876

Campos, M G; Oropeza, M V; Villanueva, T; Aguilar, M I; Delgado, G; Ponce, H A

2000-06-01

463

Surgical treatment of infected thoracic and abdominal aortic aneurysms  

Microsoft Academic Search

Twelve patients with infected aneurysms of the thoracic and abdominal aorta were evaluated. Aneurysmal location, aetiology, bacteriology and treatment modality were analysed to determine the relationship between these factors and outcome. Patients were divided into two groups based on the preoperative states of their infections. Group 1 patients (n = 7) underwent resection after resolution of their active infection. The

Y Chiba; R Muraoka; A Ihaya; T Kimura; K Morioka; M Nara; H Niwa

1996-01-01

464

AMERICAN THORACIC SOCIETY PATIENT HEALTH SERIES Lung Cancer Prevention  

E-print Network

AMERICAN THORACIC SOCIETY PATIENT HEALTH SERIES Lung Cancer Prevention What are the chances that I will develop lung cancer? The #1 cause of lung cancer is exposure to tobacco smoke. Your chances increase others (second-hand smoke), the greater your chances of developing lung cancer. People who have never

Kaski, Samuel

465

Endovascular stent–graft repair of thoracic aortic aneurysms  

Microsoft Academic Search

Conventional repair of aneurysms of the descending thoracic aorta entails thoracotomy and graft interposition. For elderly patients and those with previous operations, obesity, respiratory insufficiency, or other comorbidities, such a procedure entails significant mortality and morbidity. Transluminal stent-graft placement offers an alternative approach with potentially less morbidity and quicker recovery; however, the effectiveness and durability of stent-grafts remain uncertain. Methods:

R. Scott Mitchell; Michael D. Dake; Charles P. Semba; Thomas J. Fogarty; Christopher K. Zarins; Robert P. Liddell; D. Craig Miller

1996-01-01

466

Thoracic Hyperkyphosis: Assessment of the Distal Fusion Level  

PubMed Central

Study Design?This is a retrospective study. Objective?The objective of this study was to assess the sagittal stable vertebra (SSV) versus the first lordotic vertebra (FLV) as the inferior fusion level in patients undergoing spinal surgery for thoracic hyperkyphosis. The main outcome of interest was the development of distal junctional kyphosis (DJK). Summary of Background Data?Prior research has pointed to selection of the FLV for the distal instrumentation level in fusion for thoracic hyperkyphosis. In 2009, Cho et al introduced the concept of the SSV after recognizing the development of DJK despite fusion to the FLV. Methods?Patients were reviewed who had undergone spinal fusion for thoracic hyperkyphosis. Preoperative radiographs were reviewed to assess thoracic kyphosis, lumbar lordosis, SSV, and FLV. Postoperative radiographs were reviewed to assess curve correction and whether patients developed DJK or implant failure. Results?We reviewed 22 patients with a mean age at surgery of 18 (range 14 to 22). Mean preoperative kyphosis was 85?±?14 degrees, and mean postoperative kyphosis at final follow-up was 59?±?12 degrees for a mean correction of 26?±?12 degrees. Eleven patients developed DJK and four patients experienced hardware failure. In 12 patients, the SSV was inferior to the FLV. Rates of DJK when the instrumentation included the SSV or FLV were 13 and 38%, respectively. Conclusions?Fusion to the SSV is superior at preventing DJK when compared with fusion to the FLV. PMID:24353949

Lundine, Kristopher; Turner, Peter; Johnson, Michael

2012-01-01

467

Normal Range of Thoracic Kyphosis in Male School Children  

PubMed Central

Background. Although there are frequent studies about normal range of thoracic kyphosis, there is still a controversy about the exact values of this curve. In nine reported studies on 10 to 20 years of age boys, the value ranged from 25.1° to 53.3°. Objective for the Study. The aim of the present research was investigation of normal ranges of thoracic kyphosis in school children in Kermanshah, western Iran. Methods. 582 male students aged 13 to 18 years old using cluster random sampling were recruited from schools in Kermanshah city, 97 students for each age. Thoracic curves were measured using the flexicurve method. Results. Mean thoracic kyphosis for whole population was 35.49° SD 7.83 and plus or minus two standard deviations ranged from 19.83° to 51.15°. It increased gradually from 13 to 16 and then there was a little decrease to 18 years. Mean values for each age (13–16) were 13 (34.41 SD 7.47°), 14 (34.86 SD 8.29°), 15 (35.79 SD 7.93°), 16 (36.49 SD 7.85°), 17 (35.84 SD 8.33°), and 18 (35.55 SD 7.07°). Conclusions. Our results are in agreement with previous reports and can be used as normal values for local and regional purposes. PMID:24967122

Shamsi, MohammadBagher; Veisi, Korosh; Karimi, Loghman; Sarrafzadeh, Javad; Najafi, Farid

2014-01-01

468

Thoracic aortic plaques, transoesophageal echocardiography and coronary artery disease  

Microsoft Academic Search

Background: The purpose of this study was to assess whether the detection of atherosclerotic aortic plaques by transoesophageal echocardiogra- phy (TEE) could be used as a marker of coronary artery disease (CAD), relying on their number, cross-sectional surface, depth and localisation. Methods: The thoracic aortas of 102 consecu- tive patients (77 men, mean age 67 ± 12 years) undergoing elective

Lucka Sekoranja; Francesco Bianchi-Demicheli; Pedro T. Trindade; René Lerch

469

Vulnerability of long thoracic nerve: An anatomic study  

Microsoft Academic Search

The anatomic course of 40 long thoracic nerves was studied in relation to anatomic landmarks and reference lines, that is, the axillary lines and first 2 ribs. After its supraclavicular course, the nerve passes beneath the clavicle within the axillary sheath and then emerges from the axillary sheath. As it passes inferiorly and posteriorly from the point of emergence to

Nabil A Ebraheim; Jike Lu; Brian Porshinsky; Brace E Heck; Richard A Yeasting

1998-01-01

470

Spontaneous peri-nephric hematoma in a patient with acute kidney injury following Russell's viper envenomation.  

PubMed

Snake bite envenomation is a common cause of acute kidney injury (AKI) in the tropics and severe coagulopathy with bleeding manifestations is usually seen, especially with viperine bites. We present a case of a 34-year-old male who had developed AKI following Russell's viper envenomation along with disseminated intravascular coagulation. The patient was seemingly improving during the course of his treatment but subsequently developed a spontaneous unilateral peri-nephric hematoma and finally succumbed to this complication. This is a rare presentation that can be clinically innoccuous in a disease where there are multiple bleeding manifestations and, carries a very poor outcome. PMID:25758885

Golay, Vishal; Roychowdhary, Arpita; Pandey, Rajendra

2015-01-01

471

Kidney scintigraphy after ACE inhibition in the diagnosis of renovascular hypertension  

SciTech Connect

Suppression of the renin-angiotensin system (RAS) by angiotensin converting enzyme (ACE) inhibition may induce renal failure in patients with bilateral renal artery stenosis. Recent scintigraphic studies with the glomerular tracer technetium-99m-diethylenetriaminepenta-acetate (99m-Tc DTPA) indicate that in patients with unilateral renal artery stenosis, glomerular filtration rate (GFR) may be markedly reduced in the affected kidney after inhibition of ACE. This finding reflects the important role of the RAS in maintaining GFR (by increasing postglomerular resistance) in states of low renal perfusion pressure. Preliminary observations suggest that this scintigraphic test might be useful in the detection of renovascular hypertension.

Ghione, S.; Fommei, E.; Palombo, C.; Giaconi, S.; Mantovanelli, A.; Ragazzini, A.; Palla, L.

1986-01-01

472

Shock wave lithotripsy (SWL) induces significant structural and functional changes in the kidney  

NASA Astrophysics Data System (ADS)

The foundation for understanding SWL-injury has been well-controlled renal structural and functional studies in pigs, a model that closely mimics the human kidney. A clinical dose (2000 shocks at 24 kV) of SWL administered by the Dornier HM3 induces a predictable, unique vascular injury at F2 that is associated with transient renal vasoconstriction, seen as a reduction in renal plasma flow, in both treated and untreated kidneys. Unilateral renal denervation studies links the fall in blood flow in untreated kidneys to autonomic nerve activity in the treated kidney. SWL-induced trauma is associated with an acute inflammatory process, termed Lithotripsy Nephritis and tubular damage at the site of damage that leads to a focal region of scar. Lesion size increases with shock number and kV level. In addition, risk factors like kidney size and pre-existing renal disease (e.g., pyelonephritis), can exaggerate the predicted level of renal impairment. Our new protection data show that lesion size can be greatly reduced by a pretreatment session with low kV and shock number. The mechanisms of soft tissue injury probably involves shear stress followed by acoustic cavitation. Because of the perceived enhanced level of bioeffects from 3rd generation lithotripters, these observations are more relevant than ever.

Evan, Andrew P.; Willis, Lynn R.; Lingeman, James E.

2003-10-01

473

Pharmacokinetics of mycophenolic acid and its phenolic-glucuronide and ACYl glucuronide metabolites in stable thoracic transplant recipients.  

PubMed

Mycophenolate mofetil is an immunosuppressant commonly used in solid organ transplantation. Its active metabolite, mycophenolic acid (MPA), is metabolized to the inactive 7-O-mycophenolic acid glucuronide (MPAG) and the active acyl glucuronide (AcMPAG). Most pharmacokinetic (PK) studies have been focused on MPA, but not its metabolites, in kidney transplant recipients. Pharmacokinetic studies of MPA and its metabolites in thoracic transplant recipients are scarce. Because neither the heart nor lung is involved in MPA metabolism or excretion, the thoracic transplant population may exhibit unique PKs. This open-label study aimed to characterize and compare PKs of MPA and its metabolites in stable lung or heart transplant recipients. Fifty thoracic (27 lung, 23 heart) transplant recipients were recruited. Subjects were also taking cyclosporine (11 lung, 14 heart) or tacrolimus (16 lung, nine heart), and prednisone (27 lung, one heart). Blood samples were obtained at 0, 20, 40, 60, and 90 minutes and 2, 4, 6, 8, 10, and 12 hours postdose. Plasma was used for drug level analysis (MPA, MPAG, and AcMPAG) by a high-performance liquid chromatography-ultraviolet detection method; in a subset of subjects, free MPA concentrations were also determined. Conventional PK parameters (dose-normalized) were determined by noncompartmental methods. There was wide interpatient variability of MPA, MPAG, and AcMPAG PKs with coefficients of variation exceeding 70% for most PK parameters measured. Other findings (P < 0.05) included: lower MPA area under the curve, maximum concentration, and minimum concentration; higher apparent clearance and MPAG/MPA metabolic ratio in the lung versus heart transplant group; lower MPA area under the curve and minimum concentration, and higher apparent clearance and MPAG/MPA metabolic ratio in lung transplant recipients concurrently taking cyclosporine versus tacrolimus; and lower minimum concentration in heart transplant recipients taking cyclosporine versus tacrolimus. Despite large interpatient variability in the PKs of MPA, MPAG, and AcMPAG among thoracic transplant recipients, there appear to be significant differences between lung and heart patients, which warrant further study. PMID:18520599

Ting, Lillian S L; Partovi, Nilufar; Levy, Robert D; Riggs, K Wayne; Ensom, Mary H H

2008-06-01

474

Marginal kidney donor  

PubMed Central

Renal transplantation is the treatment of choice for a medically eligible patient with end stage renal disease. The number of renal transplants has increased rapidly over the last two decades. However, the demand for organs has increased even more. This disparity between the availability of organs and waitlisted patients for transplants has forced many transplant centers across the world to use marginal kidneys and donors. We performed a Medline search to establish the current status of marginal kidney donors in the world. Transplant programs using marginal deceased renal grafts is well established. The focus is now on efforts to improve their results. Utilization of non-heart-beating donors is still in a plateau phase and comprises a minor percentage of deceased donations. The main concern is primary non-function of the renal graft apart from legal and ethical issues. Transplants with living donors outnumbered cadaveric transplants at many centers in the last decade. There has been an increased use of marginal living kidney donors with some acceptable medical risks. Our primary concern is the safety of the living donor. There is not enough scientific data available to quantify the risks involved for such donation. The definition of marginal living donor is still not clear and there are no uniform recommendations. The decision must be tailored to each donor who in turn should be actively involved at all levels of the decision-making process. In the current circumstances, our responsibility is very crucial in making decisions for either accepting or rejecting a marginal living donor. PMID:19718332

Gopalakrishnan, Ganesh; Gourabathini, Siva Prasad

2007-01-01

475

Morphological study of the anthropoid thoracic cage: scaling of thoracic width and an analysis of rib curvature.  

PubMed

While a relatively broad thorax and strongly curved ribs are widely regarded as common features of living hominoids, few studies have quantitatively examined these traits by methods other than calculating the chest index. The present study aims to quantify variations in thoracic cage morphology for living anthropoids. The odd-numbered ribs (first to eleventh) were articulated with the corresponding vertebrae and the cranial and lateral views subsequently photographed. Rib profiles were digitized in both views and line-fitted by a Bézier curve to create a three-dimensional morphological data set. When thoracic cage width was scaled against body mass, Hylobates (and possibly Pongo) plotted above non-hominoid anthropoids at almost all rib levels, while Pan did not differ from non-hominoid anthropoids. The overall pattern of the normalized thoracic width differed between Hylobates and other hominoids. In Hylobates, an upward convex curve was seen between the first and seventh ribs while a more linear pattern was observed in Pan and Pongo. This result quantitatively confirmed that the barrel-shaped thoracic cage in Hylobates can be distinguished from the funnel-shaped form in other hominoids. Conversely, all hominoids shared two distinct features in the upper half-thorax: (1) a pronounced dorsal protrusion of the proximal part of the rib in accordance with ventral displacement of the thoracic spine and (2) a relatively medially projecting sternal end. Although these features are likely to provide some mechanical advantage in orthograde and/or suspensory positional behaviors, they were barely present in the suspensory Ateles. PMID:17902025

Kagaya, Miyuki; Ogihara, Naomichi; Nakatsukasa, Masato

2008-04-01

476

Unilateral Pedicle Stress Fracture in a Long-Term Hemodialysis Patient with Isthmic Spondylolisthesis  

PubMed Central

Most unilateral pedicle stress fractures occur on the contralateral side of patients with unilateral spondylolysis. However, there are few reports of unilateral pedicle stress fractures in patients with bilateral spondylolysis and spondylolisthesis. We report a unique case of unilateral pedicle stress fracture in a long-term hemodialysis patient with isthmic spondylolisthesis. A 65-year-old man who had undergone hemodialysis presented with lower back pain that had persisted for several years. The patient experienced severe right lower extremity pain with no history of trauma. Computed tomography revealed unilateral pedicle fracture with bilateral L5 spondylolysis and spondylolisthesis with progression of scoliosis. The patient underwent Gill laminectomy of L5 with pedicle screw fixation at L4-S1 and interbody fusion at L5-S1. The patient's leg pain ceased immediately, and he began walking without leg pain. In our present patient, development of scoliosis caused by destructive spondyloarthropathy may have contributed to a unilateral pedicle fracture. PMID:25737789

Maruo, Keishi; Tachibana, Toshiya; Inoue, Shinichi; Arizumi, Fumihiro; Yoshiya, Shinichi

2015-01-01

477

Molecular Phenotypes of Acute Kidney Injury in Kidney Transplants  

PubMed Central

Little is known regarding the molecular phenotype of kidneys with AKI because biopsies are performed infrequently. However, all kidney transplants experience acute injury, making early kidney transplants an excellent model of acute injury, provided the absence of rejection, because donor kidneys should not have CKD, post-transplant biopsies occur relatively frequently, and follow-up is excellent typically. Here, we used histopathology and microarrays to compare indication biopsies from 26 transplants with acute injury with 11 pristine protocol biopsies of stable transplants. Kidneys with acute injury showed increased expression of 394 transcripts associated with the repair response to injury, including many epithelium-like injury molecules tissue, remodeling molecules, and inflammation molecules. Many other genes also predicted the phenotype, including the acute injury biomarkers HAVCR1 and IL18. Pathway analysis of the injury-repair transcripts revealed similarities to cancer, development, and cell movement. The injury-repair transcript score in kidneys with acute injury correlated with reduced graft function, future renal recovery, brain death, and need for dialysis, but not with future graft loss. In contrast, histologic features of acute tubular injury did not correlate with function or with the molecular changes. Thus, the transcripts associated with repair of injury suggest a massive coordinated response of the kidney parenchyma to acute injury, providing both an objective measure for assessing the severity of injury in kidney biopsies and validation for many biomarkers of AKI. PMID:22343120

Famulski, Konrad S.; de Freitas, Declan G.; Kreepala, Chatchai; Chang, Jessica; Sellares, Joana; Sis, Banu; Einecke, Gunilla; Mengel, Michael; Reeve, Jeff

2012-01-01

478

The Bioartificial Kidney and Bioengineered Membranes in Acute Kidney Injury  

Microsoft Academic Search

The treatment of severe acute kidney injury (AKI) with dialysis or hemofiltration remains suboptimal with high levels of morbidity and mortality. Current renal replacement therapies substitute for the small solute clearance function of the kidney but do not replace the lost reclamation, metabolic and endocrine functions of this organ. Cell therapy and tissue engineering offer hope of fuller replacement of

Feng Ding; H. David Humes

2008-01-01

479

Inadvertent Transmission of Polycystic Kidney Disease in Kidney Transplantation  

PubMed Central

Patient: Male, 55 Final Diagnosis: Polycystic transformation of transplant kidney Symptoms: Hematuia Medication: Tacrolimus • Mycophenoalte Moefitil • Prednisone Clinical Procedure: Graft nephrectomy Specialty: Nephrology Objective: Unusual clinical course Background: Although organ donors are rigorously tested, occasionally an unidentified donor disease can be transmitted to the recipient. These conditions include malignancies, infections, and, rarely, congenital diseases. Case Report: We report a case of an inadvertent transmission of polycystic kidney disease from a 40-year-old trauma victim to both kidney recipients. There was no family history of renal disease in the donor. The renal allografts gradually increased in size with the development of cysts and functioned for 10 and 14 years. Conclusions: We report a case of inadvertent transmission of polycystic kidney disease from an unsuspecting deceased donor to both the recipients through renal allograft. Both the grafts lasted long enough to suggest that polycystic kidneys from deceased donors can be considered for transplantation. PMID:25716074

Langote, Amit; Mazarova, Andrea; Mahoney, John; Blew, Brian; Knoll, Greg A.

2015-01-01

480

Amygdalin inhibits renal fibrosis in chronic kidney disease.  

PubMed

Renal interstitial fibrosis is a common outcome of chronic renal diseases. Amygdalin is one of a number of nitrilosides, the natural cyanide?containing substances abundant in the seeds of plants of the prunasin family that are used to treat cancer and relieve pain. However, whether amygdalin inhibits the progression of renal fibrosis or not remains unknown. The present study aimed to assess the therapeutic potential of amygdalin by investigating its effect and potential mechanism on the activation of renal interstitial fibroblast cells and renal fibrosis in rat unilateral ureteral obstruction (UUO). Treatment of the cultured renal interstitial fibroblasts with amygdalin inhibited their proliferation and the production of transforming growth factor (TGF)??1. In the rat model of obstructive nephropathy, following ureteral obstruction, the administration of amygdalin immediately eliminated the extracellular matrix accumulation and alleviated the renal injury on the 21st day. Collectively, amygdalin attenuated kidney fibroblast (KFB) activation and rat renal interstitial fibrosis. These results indicate that amygdalin is a potent antifibrotic agent that may have therapeutic potential for patients with fibrotic kidney diseases. PMID:23525378

Guo, Junqi; Wu, Weizheng; Sheng, Mingxiong; Yang, Shunliang; Tan, Jianming

2013-05-01