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1

Federated Ontology Search Vasco Calais Pedro  

E-print Network

integrate and use information contained in a set of heterogeneous ontologies?" This question is becomingFederated Ontology Search Vasco Calais Pedro CMU-LTI-09-010 Language Technologies Institute School sorry I wasn't there #12;Abstract An Ontology can be defined as a formal representation of a set

Eskenazi, Maxine

2

Time, Clocks and the Speed of Light Vasco Guerra  

E-print Network

Time, Clocks and the Speed of Light Vasco Guerra and Rodrigo de Abreu Departamento de Física are a direct consequence of the fundamental notions of time and clocks. They can be obtained without any time, independently of the periodic physical phenomena they are built upon and of the machinery

Guerra, Vasco

3

Comparisons of modified Vasco X-2 and AISI 9310 gear steels  

NASA Technical Reports Server (NTRS)

Endurance tests were conducted with four groups of spur gears manufactured from three heats of consumable electrode vacuum melted (CVM) modified Vasco X-2. Endurance tests were also conducted with gears manufactured from CVM AISI 9310. Bench type rolling element fatigue tests were conducted with both materials. Hardness measurements were made to 811 K. There was no statistically significant life difference between the two materials. Life differences between the different heats of modified Vasco X-2 can be attributed to heat treat variation and resultant hardness. Carburization of gear flanks only can eliminate tooth fracture as a primary failure mode for modified Vasco X-2. However, a tooth surface fatigue spall can act as a nucleus of a tooth fracture failure for the modified Vasco X-2.

Townsend, D. P.; Zaretsky, E. V.

1980-01-01

4

Johnson-Cook Strength Model Constants for VascoMax 300 and 1080 Steels  

Microsoft Academic Search

High strength steels, VascoMax 300 and 1080, are characterized under tension at strain rates of ?1\\/s, ?500\\/s, ?1000\\/s, and ?1500\\/s and at high temperatures using the quasi-static and split Hopkinson bar techniques. The data on 1080 steel exhibited a typical strain hardening response, whereas Vasco-Max 300 steel showed diminishing flow stress beyond yielding because of localized necking in gauge section

J. D. Cinnamon; A. N. Palazotto; N. S. Brar; Z. Kennan; D. Bajaj

2006-01-01

5

Johnson-Cook Strength Model Constants for VascoMax 300 and 1080 Steels  

Microsoft Academic Search

High strength steels, VascoMax 300 and 1080 steel, are characterized under tension at strain rates of ˜1\\/s, ˜500\\/s, ˜1000\\/s, and ˜1500\\/s and at high temperatures (1000°F for Vascomax 300 and 1080 steel to 750°F) using the quai-static and split Hopkinson bar techniques. The data on 1080 steel exhibit a strain hardening response, whereas VascoMax 300 steel showed diminishing flow stress

John D. Cinnamon; N. S. Brar

2005-01-01

6

Johnson-Cook Strength Model Constants for VascoMax 300 and 1080 Steels  

Microsoft Academic Search

High strength steels, VascoMax 300 and 1080, are characterized under tension at strain rates of ~1\\/s, ~500\\/s, ~1000\\/s, and ~1500\\/s and at high temperatures using the quasi-static and split Hopkinson bar techniques. The data on 1080 steel exhibited a typical strain hardening response, whereas Vasco-Max 300 steel showed diminishing flow stress beyond yielding because of localized necking in gauge section

J. D. Cinnamon; A. N. Palazotto; N. S. Brar; Z. Kennan; D. Bajaj

2006-01-01

7

VASCo: computation and visualization of annotated protein surface contacts  

PubMed Central

Background Structural data from crystallographic analyses contain a vast amount of information on protein-protein contacts. Knowledge on protein-protein interactions is essential for understanding many processes in living cells. The methods to investigate these interactions range from genetics to biophysics, crystallography, bioinformatics and computer modeling. Also crystal contact information can be useful to understand biologically relevant protein oligomerisation as they rely in principle on the same physico-chemical interaction forces. Visualization of crystal and biological contact data including different surface properties can help to analyse protein-protein interactions. Results VASCo is a program package for the calculation of protein surface properties and the visualization of annotated surfaces. Special emphasis is laid on protein-protein interactions, which are calculated based on surface point distances. The same approach is used to compare surfaces of two aligned molecules. Molecular properties such as electrostatic potential or hydrophobicity are mapped onto these surface points. Molecular surfaces and the corresponding properties are calculated using well established programs integrated into the package, as well as using custom developed programs. The modular package can easily be extended to include new properties for annotation. The output of the program is most conveniently displayed in PyMOL using a custom-made plug-in. Conclusion VASCo supplements other available protein contact visualisation tools and provides additional information on biological interactions as well as on crystal contacts. The tool provides a unique feature to compare surfaces of two aligned molecules based on point distances and thereby facilitates the visualization and analysis of surface differences. PMID:19166624

Steinkellner, Georg; Rader, Robert; Thallinger, Gerhard G; Kratky, Christoph; Gruber, Karl

2009-01-01

8

Johnson-Cook Strength Model Constants for VascoMax 300 and 1080 Steels  

SciTech Connect

High strength steels, VascoMax 300 and 1080, are characterized under tension at strain rates of {approx}1/s, {approx}500/s, {approx}1000/s, and {approx}1500/s and at high temperatures using the quasi-static and split Hopkinson bar techniques. The data on 1080 steel exhibited a typical strain hardening response, whereas Vasco-Max 300 steel showed diminishing flow stress beyond yielding because of localized necking in gauge section of the tested specimens. The tension data are analyzed to determine the Johnson-Cook (J-C) strength model constants for the two steels. The flow stress values for VascoMax are adjusted to account for necking, and the corrected J-C model is developed.

Cinnamon, J. D.; Palazotto, A. N.; Kennan, Z. [Department of Aeronautics and Astronautics, Air Force Institute of Technology, WPAFB, OH 45433 (United States); Brar, N. S.; Bajaj, D. [University of Dayton Research Institute, Dayton, OH 45469-0182 (United States)

2006-07-28

9

Cryptanalysis of a key exchange scheme based on block matrices Maria Isabel Gonzalez Vasco  

E-print Network

Cryptanalysis of a key exchange scheme based on block matrices Mar´ia Isabel Gonz´alez Vasco , Angel L. P´erez del Pozo and Pedro Taborda Duarte Dpto. de Matem´atica Aplicada, Universidad Rey Juan

10

Endurance and failure characteristics of modified Vasco X-2, CBS 600 and AISI 9310 spur gears. [aircraft construction materials  

NASA Technical Reports Server (NTRS)

Gear endurance tests and rolling-element fatigue tests were conducted to compare the performance of spur gears made from AISI 9310, CBS 600 and modified Vasco X-2 and to compare the pitting fatigue lives of these three materials. Gears manufactured from CBS 600 exhibited lives longer than those manufactured from AISI 9310. However, rolling-element fatigue tests resulted in statistically equivalent lives. Modified Vasco X-2 exhibited statistically equivalent lives to AISI 9310. CBS 600 and modified Vasco X-2 gears exhibited the potential of tooth fracture occurring at a tooth surface fatigue pit. Case carburization of all gear surfaces for the modified Vasco X-2 gears results in fracture at the tips of the gears.

Townsend, D. P.; Zaretsky, E. V.

1980-01-01

11

The Aula Espazio and the Master of Space Science & Technology in the Universidad del País Vasco (Spain)  

Microsoft Academic Search

We present the Aula Espazio, a facility dedicated to teach Space Sciences and Technology at Master and Doctorate level at the Universidad del País Vasco(Spain)and to promote development in this field in both the public and private sectors. A new University Observatory which homes a 50 cm telescope, a solar telescope and other instruments is also associated to the Aula.

A. Sanchez-Lavega; S. Pérez-Hoyos; R. Hueso; T. Del Río-Gaztelurrutia; A. Oleaga

2010-01-01

12

Nitrogen pink afterglow: the mystery continues Vasco Guerra1, Paulo A. Sa2 and Jorge Loureiro1  

E-print Network

Nitrogen pink afterglow: the mystery continues Vasco Guerra1, Paulo A. S´a2 and Jorge Loureiro1 1@ist.utl.pt Abstract. This work extends our previous analysis of the nitrogen pink afterglow, by comparing our model. As singlet N2(a 1 - u ) metastables play a crucial role in nitrogen ionization, the new results imply

Guerra, Vasco

13

Teaching Planetary Sciences at the Universidad del País Vasco in Spain: The Aula Espazio Gela and its Master in Space Science and Technology  

NASA Astrophysics Data System (ADS)

Planetary science is a highly multidisciplinary field traditionally associated to Astronomy, Physics or Earth Sciences Departments. Spanish universities do not generally offer planetary sciences courses but some departments give courses associated to studies on Astronomy or Geology. We show a different perspective obtained at the Engeneering School at the Universidad del País Vasco in Bilbao, Spain, which offers a Master in Space Science and Technology to graduates in Engineering or Physics. Here we detail the experience acquired in two years of this master which offers several planetary science courses: Solar System Physics, Astronomy, Planetary Atmospheres & Space Weather together with more technical courses. The university also owns an urban observatory in the Engineering School which is used for practical exercises and student projects. The planetary science courses have also resulted in motivating part of the students to do their master thesis in scientific subjects in planetary sciences. Since the students have very different backgrounds their master theses have been quite different: From writing open software tools to detect bolides in video observations of Jupiter atmosphere to the photometric calibration and scientific use or their own Jupiter and Saturn images or the study of atmospheric motions of the Venus' South Polar Vortex using data from the Venus Express spacecraft. As a result of this interaction with the students some of them have been engaged to initiate Ph.D.s in planetary sciences enlarging a relative small field in Spain. Acknowledgements: The Master in Space Science and Technology is offered by the Aula Espazio Gela at the Universidad del País Vasco Engineer School in Bilbao, Spain and is funded by Diputación Foral de Bizkaia.

Hueso, R.; Sanchez-Lavega, A.; Pérez-Hoyos, S.

2011-12-01

14

Globalization and the Rule of Law Jeffrey D. Sachs  

E-print Network

greater specialization; induces innovation; and facilitates the diffusion of technologies. Since Vasco da? It is the intertwining and intensification of two profound trends: the globalization of society and the diffusion

15

DA FALA À ESCRITA: OS SABERES DA ORALIDADE E O INÍCIO DE PRODUÇÃO DA ESCRITA ESCOLAR  

Microsoft Academic Search

Resumo: Analisa a integração dos saberes da oralidade de a lfabetizandos e o processo de aquisição da escrita escolar embasado em fundamentos da Sociolingüística Educacional. A pesquisa foi desenvolvida considerando princípios metodológicos da Etnografia Colaborativa Educacional. Foi realizada em uma escola da Secretaria de Estado de Educação do Distrito Federal, mais especificamente, em uma sala de alfab etização. Esta sala

Maria Alice Fernandes de Sousa

16

Fotopoética da Cidade  

Microsoft Academic Search

The research considers the imaginary nature of the Urban space through a reading of the aesthetic analysis of images of the photographic creation. Gaston Bachelard's Phenomenology of the creative Imagination and poetic Image brings the conceptual base of the study. Fotografia, Arte, Urbanismo, Bachelard, Imaginação. Apresentação Investigamos a natureza poética do fenômeno urbano, através da análise fenomenológica de imagens da

Carlos Alberto Murad

17

Evolução da regulamentação da mídia eletrônica no Brasil  

Microsoft Academic Search

comunicação eletrônica e de massa como hoje a conhecemos por meio do rádio, da televisão, dos telefones, da internet ou de qualquer conver- gência tecnológica está prestes a passar por mais uma mudança estrutural: da transmissão analógica para a transmissão digital. Essa mudança vai possibi- litar inúmeras - e ainda não totalmente conhecidas - formas de interligação desses meios. Tal

Edgard Rebouças; Mariana Martins

2007-01-01

18

Data da Solicitao:_________ Hora:_____________________  

E-print Network

Aluno Dados pessoais Nome: Telefone: CPF: E-mail: Dados de Matrícula ( ) Asa Norte ( ) Ceilândia outro titular preencher os dados abaixo do responsável pela conta. Nome do Titular: CPF do Titular da

Maier, Rudolf Richard

19

CARACTERÍSTICAS, OPERACIONALIDADE E PRODUÇÃO DA FROTA SERREIRA NO MUNICÍPIO DA RAPOSA - MA  

Microsoft Academic Search

Este trabalho aborda as características, operacionalidade e produção pesqueira da frota serreira, no município da Raposa, no período de março a dezembro de 2003, com desembarques nos portos da Praia da Raposa e Braga. Os dados utilizados são provenientes da Capitania dos Portos do Maranhão, Progra- ma Revizee (Recursos Vivos da Zona Econômica exclusiva) e da comunidade de pescadores do

Elizabeth Galvão Soares; Milton Gonçalves da Silva Júnior

20

ANÁLISE DA COMPETITIVIDADE DA FRUTICULTURA BRASILEIRA FRENTE A MUNDIAL  

Microsoft Academic Search

O presente estudo teve como objetivo analisar a competitividade da fruticultura brasileira frente aos maiores produtores das principais frutas que compõem nossa pauta de exportação: banana, citros (laranja, lima\\/limão e tangerina), maçã, mamão, manga, melão e uva – apresentadas em ordem alfabética. Juntas representaram em 2007 cerca de 93% da receita gerada com a exportação de frutas no País. Foi

Aline Vitti; Margarete Boteon

2008-01-01

21

Da Causalidade à Indecidibilidade em Ciências da Terra  

Microsoft Academic Search

As Ciências da Terra estudam a historia da Terra mas também os processos que aí ocorrem. São simultaneamente Ciências Históricas e Dinâmicas. O principio das causas actuais, enunciado por Lyell no século XIX, procurava explicar o passado a partir do presente e levou ao uniformismo, que suplantou o catastrofismo ainda no século XIX. Mas a observação dos processos em profundidade

A. Ribeiro

22

Comportamento da freqüência cardíaca e da pressão arterial, ao longo da gestação, com treinamento no meio líquido  

Microsoft Academic Search

RESUMO Objetivo: O objetivo deste estudo foi avaliar o comportamento da freqüência cardíaca (FC) ao longo da gestação, antes, durante e após as aulas de hidroginástica, e o da pressão arterial (PA) antes e após o mesmo exercício. Métodos: A amostra foi composta por sete gestantes. A leitura da FC foi realizada em três momentos: 1) na artéria radial, em

Ilana Finkelstein; Roberta Bgeginski; Marcus Peikriszwili Tartaruga; Cristine Lima Alberton; Luiz Fernando Martins Kruel

2006-01-01

23

RESULTADOS DA I CONVOCATORIA DO  

E-print Network

de Ciencias do Deporte e a E.F. 16 14 9 6 3 Facultade de Ciencias Económicas e Empresariais 13 5 3 1 Saúde Facultade de Ciencias do Deporte e a E.F. Facultade de Ciencias Económ icas e Em presariais Ciencias da Educación Facultade de Ciencias da Saúde Facultade de Ciencias do Deporte e a E.F. Facultade de

Fraguela, Basilio B.

24

Ministrio da Educao UNIVERSIDADE FEDERAL DO PARAN  

E-print Network

nº __________________________e CPF ___________________________________, inscrito no Concurso Público do Titular da Conta: ______________________________________________________________ CPF do Titular da: _______________________________________ E-mail: _________________________________________ 3. Anexar cópia do RG; CPF; comprovante

Paraná, Universidade Federal do

25

Leonardo da Vinci and the Downburst.  

NASA Astrophysics Data System (ADS)

Evidence from the drawings, experiments, and writings of Leonardo da Vinci are presented to demonstrate that da Vinci recognized and, possibly, discovered the downburst and understood its associated airflow. Other early references to vortex flows resembling downbursts are mentioned.

Gedzelman, Stanley David

1990-05-01

26

Leonardo da Vinci and the Downburst  

Microsoft Academic Search

Evidence from the drawings, experiments, and writings of Leonardo da Vinci are presented to demonstrate that da Vinci recognized and, possibly, discovered the downburst and understood its associated airflow. Other early references to vortex flows resembling downbursts are mentioned.

Stanley David Gedzelman

1990-01-01

27

Ministrio da Educao Universidade Federal do Paran  

E-print Network

Extensão Gestão da qualidade dos alimentos nos Armazéns da Família da Secretaria Municipal do Abastecimento, lipídios, carboidratos, fibra alimentar, sódio e valor calórico) dos alimentos comercializados nos Armazéns de Curitiba e Laboratório de Análise de Alimentos do Departamento de Nutrição da UFPR Inscrições

Paraná, Universidade Federal do

28

Leonardo Da Vinci: A Review  

Microsoft Academic Search

The article reviews scholarship on Leonardo da Vinci during the 20th century. An initial fascination with a handful of paintings has led to a nearly comprehensive understanding of his art. A catalogue raisonnée for Leonardo and his school has yet to be made. Awareness of Leonardo as a scientist began with a vague reputation of a universal genius who never

Kim H. Veltman

2008-01-01

29

Leonardo da Vinci: A Review  

Microsoft Academic Search

The article reviews scholarship on Leonardo da Vinci during the 20th century. An initial fascination with a handful of paintings has led to a nearly comprehensive understanding of his art. A catalogue raisonnée for Leonardo and his school has yet to be made. Awareness of Leonardo as a scientist began with a vague reputation of a universal genius who never

Kim H. Veltman

2008-01-01

30

SERVIO PBLICO FEDERAL MINISTRIO DA EDUCAO  

E-print Network

entregue lacrado no ato da inscrição (Anexo I); c) cópias autenticadas da Carteira de Identidade (CI) e CPF CI e CPF. No caso de candidato estrangeiro, deve-se apresentar cópia autenticada da página de

Floeter, Sergio Ricardo

31

After Twenty Years: The Future of the Third Wave  

Microsoft Academic Search

Some five hundred years ago a small group of Portuguese leaders and thinkers--including King John II, Prince Henry the Navigator, Bartholomew Dias, and Vasco da Gama--acting with courage, determination, and imagination, inaugurated a new phase in human history, the age of discovery. They set an example that Spain, France, Britain, and the Netherlands were to follow. Slightly more than two

Samuel P. Huntington

2008-01-01

32

Some radical queries  

Microsoft Academic Search

A little over 500 years ago, Vasco da Gama arrived on the west coast of India after the first direct sea voyage from Portugal with the intention of developing trade in spices, particularly in black pepper. Portugese took the merchandise, and much more; they ended up colonizing Goa. In 1999 delegates from all over the world came to this fabulous

T Ramasarma

2000-01-01

33

El metabolismo social del País Vasco desde el análisis de flujos materiales  

Microsoft Academic Search

La desvinculación de la mejora del bienestar respecto del uso de los recursos y de la contaminación es esencial para lograr un desarrollo sostenible. Para avanzar en esta dirección es preciso partir del conocimiento del metabolismo de la sociedad. Es decir, debemos analizar en qué medida nuestras sociedades “ingieren” materias primas, que son “metabolizadas” para producir bienes y servicios, y

Iñaki Arto

2009-01-01

34

Donald W. Vasco Earth Sciences Division/Building 90-1116  

E-print Network

-linear inverse problems; Seismic tomographic imaging; Use of geodetic observations to constrain subsurface fluid of Texas at Austin, May 1981. PhD., University of California at Berkeley, 1987, Dissertation: Inversion Scientist, Berkeley Laboratory Current Research Interests and Experience Geophysical inversion and non

Ajo-Franklin, Jonathan

35

ofPais Vasco, cIMarqu4!s de Urquijo sln, 01006 Vitoria, Spain).).  

E-print Network

(A), rats fed a hypercholesterolemic diet prepared by changing casein by Vicia faba (B) and rats fed a hypercholesterolemic diet prepared by changing casein by Vicia faba protein concentrate (C). At the end!l for 45 min each time. Arterialized blood was collected. Isotopic enrichments were performed and concen

Paris-Sud XI, Université de

36

Leonardo da Vinci's Geometric Sketches  

NSDL National Science Digital Library

How do you solve a problem like solids, mathematically speaking? Well, you could use this rather fascinating resource provided by the Convergence magazine. Offered as an educational resource by the Mathematical Association of America (MAA), this particular resource brings together the work of the Franciscan friar Luca Pacioli (c.1445-1509) and the geometric sketches of Leonardo Da Vinci. Both men were interested in geometry, and this piece offers up a number of plate facsimiles of illustrations created by Da Vinci. Here visitors will find an introduction to this educational resource, along with illustrations of cubes, octahedrons, and cylinders. The accompanying article was written by Frank J. Swetz, and it is easy to see how these materials could be incorporated into a classroom discussion about the history of mathematics.

2008-09-15

37

Leonardo da Vinci's Geometric Sketches  

NSDL National Science Digital Library

How do you solve a problem like solids, mathematically speaking? Well, you could use this rather fascinating resource provided by the Convergence magazine. Offered as an educational resource by the Mathematical Association of America (MAA), this particular resource brings together the work of the Franciscan friar Luca Pacioli (c.1445-1509) and the geometric sketches of Leonardo Da Vinci. Both men were interested in geometry, and this piece offers up a number of plate facsimiles of illustrations created by Da Vinci. Here visitors will find an introduction to this educational resource, along with illustrations of cubes, octahedrons, and cylinders. The accompanying article was written by Frank J. Swetz, and it is easy to see how these materials could be incorporated into a classroom discussion about the history of mathematics.

38

Lembranías da Companhia dramática Nacional  

E-print Network

Melhor Atriz, em A Falecida, de Nelson Rodrigues; a Nilson Pena, de Melhor Cenógrafo e Figurinista de Canção dentro do Põ, de R. Magalhães Jr.; e a Anísio Medeiros, de Melhor Cenógrafo e Figurinista de A Raposa e as Uvas; todos em dinheiro da... Falecida, de Nelson Rodrigues, A Raposa e as Uvas, de Guilherme Figueiredo, e Canção dentro do Pão, de R. Magalhães Jr. Três diretores-encenadores trabalharam simultaneamente as peças mencionadas a saber, respectivamente, José Maria Monteiro, Bibi...

Calvet, Aldo

1984-04-01

39

Leonardo da Vinci (1452-1519)  

NSDL National Science Digital Library

This is a biographical sketch of Leonardo da Vinci. Leonardo da Vinci was a painter, sculptor, architect, engineer, scientist and genius who best represents the ideals of the Renaissance period. He was one of the greatest painters of all times. Da Vinci was also a great engineer and inventor who designed buildings, bridges, canals, forts and war machines. He was fascinated by birds and flying and drew designs of fantastic flying machines.

Laboratory, Florida S.

1999-01-01

40

Ministrio da Educao Secretaria de Educao Superior  

E-print Network

63/2010, da DN TCU nº 127/2013, da Portaria TCU nº 175/2013 e das orientações do órgão de controle Telefones: (61) 3107-0610 e 3107-0612 Fax: (61) 3274-5915 http://www.unb.br ­ dpo@unb.br #12;Gestor e Editor

Maier, Rudolf Richard

41

MINISTRIO DA EDUCAO SECRETARIA DE EDUCAO SUPERIOR  

E-print Network

estudante deverá informar seu número do Cadastro de Pessoas Físicas (CPF) da Secretaria da Receita Federal do Brasil (RFB) e prestar todas as informações solicitadas pelo Sistema. § 2° Somente serão ofertados

42

Virtual observatory publishing with DaCHS  

NASA Astrophysics Data System (ADS)

The Data Center Helper Suite DaCHS is an integrated publication package for building VO and Web services, supporting the entire workflow from ingestion to data mapping to service definition. It implements all major data discovery, data access, and registry protocols defined by the VO. DaCHS in this sense works as glue between data produced by the data providers and the standard protocols and formats defined by the VO. This paper discusses central elements of the design of the package and gives two case studies of how VO protocols are implemented using DaCHS' concepts.

Demleitner, M.; Neves, M. C.; Rothmaier, F.; Wambsganss, J.

2014-11-01

43

The potentially dangerous asteroid 2012 DA14  

NASA Astrophysics Data System (ADS)

We present computing methods that allow us to study the behaviour of the dynamically interesting potentially dangerous asteroid 2012 DA14. Using the freely available ORBFIT software, we can follow the orbit of the asteroid backward and forward in the future, searching for close approaches to the Earth that might lead to possible impacts. The possible impact orbit for 2026 is computed. We show that it should be possible to recover asteroid 2012 DA14, mainly in 2013 February. It is highly unlikely that asteroid 2012 DA14 will hit any geosynchronous satellites during its close approach on 2013 February 15.

Wlodarczyk, I.

2012-12-01

44

Origin of the DA and non-DA white dwarf stars  

NASA Technical Reports Server (NTRS)

Various proposals for the bifurcation of the white dwarf cooling sequence are reviewed. 'Primordial' theories, in which the basic bifurcation of the white dwarf sequence is rooted in events predating the white dwarf stage of stellar evolution, are discussed, along with the competing 'mixing' theories in which processes occurring during the white dwarf stage are responsible for the existence of DA or non-DA stars. A new proposal is suggested, representing a two-channel scenario. In the DA channel, some process reduces the hydrogen layer mass to the value of less than 10 to the -7th. The non-DA channel is similar to that in the primordial scenario. These considerations suggest that some mechanism operates in both channels to reduce the thickness of the outermost layer of the white dwarf. It is also noted that accretion from the interstellar medium has little to do with whether a particular white dwarf becomes a DA or a non-DA star.

Shipman, Harry L.

1989-01-01

45

SOPHIA ANDRESEN: UMA POÉTICA DA FELICIDADE E DO DIA?  

Microsoft Academic Search

RESUMO: A comunicação aqui proposta aponta como linha de leitura da poesia de Sophia de Mello Breyner Andresen uma reflexão em torno da presença de ecos da lírica horaciana e da doutrina epicurista, seja como ponto declarado de divergência, de encontro e acordo, ou mesmo em intertextualidade com autores que trabalharam idéias e valores daquela doutrina, principalmente Pessoa - Reis.

Virgínia Bazzetti Boechat

46

Programma Leonardo da Vinci Progetto "Jobs4graduates-2"  

E-print Network

Programma Leonardo da Vinci Progetto "Jobs4graduates-2" Accettazione del contributo I candidati accettare la Borsa di tirocinio del Programma Leonardo da Vinci, come indicato nel formulario di candidatura, debitamente giustificata e potrà costituire motivo di esclusione da eventuali successivi progetti Leonardo da

Di Pillo, Gianni

47

CENTRO DE ENGENHARIAS DA MOBILIDADE CEM  

E-print Network

-Administrativos estão lotados em diversos setores como: Biblioteca, Infraestrutura, Laboratórios, Psicologia Organizacional, Secretaria Acadêmica, Secretaria Administrativa, Secretaria Executiva e Tecnologia da Informação

Floeter, Sergio Ricardo

48

Ministrio da Educao UNIVERSIDADE FEDERAL DO PARAN  

E-print Network

CLAUDIA NOGUEIRA FRANCINE BAESSO GUIMAR�ES ASTRATH OMAR CL�O NEVES PEREIRA DANIEL GUIMAR�ES TEDESCO CAVALCANTE ALINE ROSSETTO DA LUZ Educação IVAIR FERNANDES DE AMORIM FABIO LUCIANO OLIVEIRA COSTA MARCELO

Paraná, Universidade Federal do

49

Ministrio da Educao Universidade Federal do Paran  

E-print Network

banco de dados com informações do acervo de etnologia; escanerização de material relativo a peças da e Patrimônio do MAE, como a catalogação das peças em base de dados, pesquisa a respeito da Cultura suporte e gênero documental (papel, filmes, documentos sonoros e outros): higienização, classificação

Paraná, Universidade Federal do

50

Ministrio da Educao UNIVERSIDADE FEDERAL DO PARAN  

E-print Network

Ministério da Educação UNIVERSIDADE FEDERAL DO PARANÁ Pró-Reitoria de Gestão de Pessoas EDITAL Nº Deferido Curitiba, 04 de novembro de 2014. Adriano do Rosário Ribeiro Pró-Reitor de Gestão de Pessoas Ministério da Educação UNIVERSIDADE FEDERAL DO PARANÁ Pró-Reitoria de Gestão de Pessoas EDITAL Nº 458

Paraná, Universidade Federal do

51

Jornal da UFF PROGRAMA DE ACOLHIMENTO ESTUDANTIL  

E-print Network

com a impossibilidade de fugir dela. O segundo momento se refere à morte da cachorra Baleia. Tanto progressiva animalização de Fabiano e sua família. Esta humanização atinge seu ápice no mo- mento da morte a nossa idéia de morte. As imagens do filme nos transmitem a sensação de afastamen- to, de perda do

Souza, Max O.

52

DaFEx: Database of Facial Expressions  

Microsoft Academic Search

\\u000a DaFEx (Database of Facial Expressions) is a database created with the purpose of providing a benchmark for the evaluation\\u000a of the facial expressivity of Embodied Conversational Agents (ECAs). DaFEx consists of 1008 short videos containing emotional\\u000a facial expressions of the 6 Ekman’s emotions plus the neutral expression. The facial expressions were recorded by 8 italian\\u000a professional actors (4 male and

Alberto Battocchi; Fabio Pianesi; Dina Goren-bar

2005-01-01

53

Situação da Mulher na Astronomia Brasileira  

NASA Astrophysics Data System (ADS)

O conteúdo desse texto surgiu de uma apresentação de mesmo título que fiz na XXXI Reunião Anual da Sociedade Astronômica Brasileira (SAB) em 2005. Esse tema foi inspirado originalmente pela minha participação no "2nd UIPAP International Conference on Women in Physics" realizado entre 23 e 25 de maio de 2005 no Rio de Janeiro. Essa é uma conferência internacional que acontece de três em três anos, sendo que a primeira ocorreu em 2002 na cidade de Paris, França. Participei dessa conferência como membro da delegação da Sociedade Brasileira de Física e um dos trabalhos que apresentei versava sobre a situação das mulheres na Astronomia brasileira, cujos resultados principais discorro a seguir. A situação das astrônomas, baseada nos dados dos sócios da SAB coletados no final de 2004, é comparada com a das físicas brasileiras e também com as nossas colegas americanas. Os dados identificam ainda uma maior evasão da carreira por parte das mulheres do que os homens. Alguns dos possíveis motivos da evasão são discutidos, como o desejo de constituir família e/ou isolamento. Resultados um tanto preocupantes com relação à distribuição de bolsas de produtividade do CNPq também são apresentados. As principais discussões e estratégias recomendadas nesse congresso são mencionadas de forma resumida ao final.

Silva, Adriana V. R.

2007-07-01

54

Teoria da Medida e outras contribuic~oes  

E-print Network

Teoria da Medida e outras contribui¸c~oes CHAIM SAMUEL H ¨ ONIG H ' a uma dificuldade natural para particular nas contribui¸c~oes de von Neumann ` a Teoria da Medida e a alguns t'opicos da An'alise. Suas poucos anos, os problemas fundamentais da Teoria da Integra¸c~ao que estavam em aberto: problemas de s

Kohayakawa, Yoshiharu

55

FRAGMENTOS DO PENSAMENTO DIALÉTICO NA HISTÓRIA DA CONSTRUÇÃO DAS CIÊNCIAS DA NATUREZA  

Microsoft Academic Search

Resumo: Este trabalho tem por objetivo identificar uma possível inclinação das ciências naturais em direção ao materialismo dialético. Para tanto, procura-se apresentar a história da dialética a partir da discussão racionalismo\\/empirismo moderno e seus desdobramentos até as tendências dialéticos contem- porâneas. Os autores discutidos são Kant, Hegel, Marx, Engels, Lenin, Horkheimer, Marcuse, Habermas, Bachelard e suas escolas epistemológicas, completadas por

Antônio Fernandes; Nascimento Júnior

56

Avaliação da eficácia e tolerabilidade da vigabatrina na síndrome de West  

Microsoft Academic Search

RESUMO - A síndrome de West (SW) é uma epilepsia grave específica da infância, que se caracteriza pela tríade: espasmos em salvas, deterioração ou atraso neuropsicomotor e hipsarritmia ao eletre n c e f a l o g r a m a . O b j e t i v o:Avaliar a eficácia e segurança da vigabatrina (VGB) no tratamento

Maria Helena P. Moraes; Maria Augusta Montenegro; Renata C. Franzon; José O. Ávila; Marilisa M. Guerreiro

2005-01-01

57

A produção de sentidos no jornalismo: da teoria da enunciação a enunciação jornalística  

Microsoft Academic Search

RESUMO: Este trabalho tem como objetivo fazer uma discussão teórica do jornalismo não como um simples repr odutor do real, mas com o um a atividad e que diariamente contribui para a construção social d a realidade . Acreditamo s que a concepção do jorna lismo como um espelho da realidade desconhece a dimensão s imbólica da atividade . Ne

Alfredo Vizeu

58

INFLUÊNCIA DA DESIDRATAÇÃO NA RECUPERAÇÃO DA FIRMEZA E NA BROTAÇÃO EM CENOURA(1)  

Microsoft Academic Search

RESUMO Raízes de cenoura Daucus Carota L. Brasília recém-colhidas foram submetidas a diferentes níveis de desidratação com emprego de ventilação forçada a 25 ± 2 °C. Sob teores relativos de água inferiores a0 ,95 af irmeza dependente da pressão celular, medida com at écnica da aplanação, ficou reduzida a praticamente zero, ao passo que as raízes do tratamento controle tiveram

ADONAI GIMENEZ CALBO

59

ISSN 0103-9741 Monografias em Cincia da Computao  

E-print Network

Tecnologia da Presidência da República Federativa do Brasil #12;#12;In charge for publications Rosane Teles is an interactive performance art form, wherein the teller adjusts the vocalization, wording, physical movements

Endler, Markus

60

CURSO DE MUSICALIZAÇÃO PARA BEBÊS DA UFBA  

Microsoft Academic Search

RESUMO: Considerando a importância da Educação Musical na primeira infância e os benefícios que esta pode trazer, este artigo tem o intuito de descrever e analisar os resultados do primeiro semestre do curso de musicalização para bebês na UFBA, que teve início em setembro de 2006, contemplando crianças com idades entre 0 e 4 anos, acompanhadas de seus responsáveis. Para

Angelita Maria Vander Broock

61

Ministrio da Educao UNIVERSIDADE FEDERAL DO PARAN  

E-print Network

Nutrição e Alimentos, ou Nutrição Humana, ou Tecnologia de Alimentos, ou Engenharia de Alimentos, Ciência de Alimentos, obtidos na forma da lei. Tipos de Provas: Escrita (classificatória e eliminatória

Paraná, Universidade Federal do

62

How to Think Like Leonardo da Vinci  

ERIC Educational Resources Information Center

To be effective and relevant in twenty-first-century learning, art needs to be more inclusive. In this article, the author discusses how teachers can find a good example in Leonardo da Vinci for building an art program. His art, design, and curiosity are the perfect foundation for any art program, at any level. (Contains 3 resources and 3 online…

Caouette, Ralph

2008-01-01

63

Ministrio da Educao Universidade Federal do Paran  

E-print Network

DO CPF NOME SEXO DATA DE NASCIMENTO GRUPO SANG�ÍNEO FATOR RH / / A B AB O + - NOME DO PAI NOME DA M�E �RG�O EMISSOR U. F. DADOS DO C�NJUGE CPF NOME NACIONALIDADE CIDADE DE NASCIMENTO DATA NASCIMENTO U. F

Paraná, Universidade Federal do

64

Ministrio da Educao UNIVERSIDADE FEDERAL DO PARAN  

E-print Network

PESSOAIS DO SERVIDOR NOME MATRÍCULA SIAPE CPF CARGO FUN��O INSTITUI��O MEC ­ UNIVERSIDADE FEDERAL DO PARANÁ e às respectivas retificações entregues à Secretaria da Receita Federal do Brasil. LOCAL DATA

Paraná, Universidade Federal do

65

Das Weimarer Anatomieblatt Leonardo da Vincis  

Microsoft Academic Search

Zum Thema Leonardo da Vinci (1452-1519) hat in seiner 2. Lebenshälfte eine Vielzahl von anatomischen Studien durchgeführt und seine Skizzenblätter zeugen nicht nur von seinem künstlerischem Können, sondern auch von seiner Stellung als Wissenschaftler. Heute befindet sich nahezu die komplette Sammlung der erhaltenen anatomischen Skizzenbücher Leonardos im Besitz des Englischen Königshauses und wird in der Royal Library in Windsor Castle

D. Schultheiss; D. Laurenza; B. Götte; U. Jonas

2000-01-01

66

Leonardo da Vinci's contributions to neuroscience  

Microsoft Academic Search

Leonardo da Vinci (1452–1519) made far-reaching contributions to many areas of science, technology and art. Leonardo's pioneering research into the brain led him to discoveries in neuroanatomy (such as those of the frontal sinus and meningeal vessels) and neurophysiology (he was the first to pith a frog). His injection of hot wax into the brain of an ox provided a

Jonathan Pevsner

2002-01-01

67

ASPECTOS DA CORTESIA VERBAL NO DISCURSO INFANTIL  

Microsoft Academic Search

RESUMO . Neste trabalho, refletiremos sobre a questão da cortesia verbal (ou polidez linguística) no discurso infantil, inspirando-nos nos estudos de Brown e Levinson (1987), que retomam e ampliam a conceituação de face proposta por Goffman (1970). Para o sociólogo americano, a face pode ser entendida como o valor social positivo que uma pessoa reivindica para si. Assim, Brown e

Giovanna Wrubel Brants

68

Procura de Vida Fora da Terra  

E-print Network

Biological Entities") #12;O desenvolvimento e teste de teorias sobre a vida extraterrestre é conhecido como combustível celular (energia química) fotosíntese converter luz em energia! elementos estruturais (Ex, com inteligência superior à nossa. Várias teorias tem sido propostas para as bases da vida

dos Santos, C.A.

69

The Real Code of Leonardo da Vinci  

Microsoft Academic Search

Leonardo da Vinci was born in Italy. Among the researchers and scientists, he is favourably known for his remarkable efforts in scientific work. His investigations of atherosclerosis judiciously combine three separate fields of research. In 1506, he finished his masterpiece, painting of Mona Lisa. A careful clinical examination of the famous painting reveals a yellow irregular leather-like spot at the

Leiv Ose

2008-01-01

70

Leonardo da vinci e la matematica  

Microsoft Academic Search

Sunto  Lo scopo della presente Nota è quello di illustrare come Leonardo da Vinci, contrariamente a quanto sostengono molti autori,\\u000a possedesse un eccezionale talento matematico, una mentalità tipica dei matematici unita ad una sorprendente originalità. Numerose\\u000a sue idee furono riprese e realizzate nei secoli successivi.

I. S. Fenyö

1985-01-01

71

Leonardo da Vinci and Perpetual Motion  

Microsoft Academic Search

Leonardo da Vinci illustrated several traditional forms of perpetual-motion machine in small pocket books now known as the Codex Forster. He was well aware that these designs, based on waterwheel\\/pump combinations, mechanical overbalancing hammers or rolling balls, would notand could notwork.

Allan A. Mills

2008-01-01

72

UNIVERSIDADE FEDERAL DO PARAN -SETOR DE CINCIAS DA SADE SIBI -BIBLIOTECA DE CINCIAS DA SADE -SD  

E-print Network

, teses, capítulos de livros e livros. Alexandre Alessi et al. Avaliação Laboratorial nas energências. 2009 Capítulo de livro Alexandre Alessi Efeitos da Rosiglitazona em coelhos hipercolesterolêmicos

Paraná, Universidade Federal do

73

40 CFR 60.45Da - Standard for mercury (Hg).  

Code of Federal Regulations, 2011 CFR

... 2011-07-01 false Standard for mercury (Hg). 60.45Da Section 60.45Da...18, 1978 § 60.45Da Standard for mercury (Hg). (a) For each coal-fired...January 30, 2004, any gases that contain mercury (Hg) emissions in excess of each...

2011-07-01

74

A Day in the Life at DaVita Academy  

ERIC Educational Resources Information Center

When a company name means "giving life," the bar for learning and development programs is held high. In this article, the author describes what it takes to graduate from DaVita Academy, the soft skills training program dialysis services company DaVita offers all its employees. DaVita's chief executive officer, Kent Thiry, states that the Academy…

Weinstein, Margery

2010-01-01

75

ciclo di conferenze organizzato da Politecnico di Milano,  

E-print Network

'Informazione, Corso di laurea in Ingegneria delle Telecomunicazioni, Liceo Scientifico Statale Leonardo da Vinci al di'Informazione Politecnico di Milano 02.2399.9714 quintafacolta@polimi.it Liceo Scientifico Statale Leonardo da Vinci Centro dello spazio, al di là del tempo Liceo Scientifico Statale Leonardo da Vinci Centro Congressi

76

Programma "LEONARDO DA VINCI" Progetto UNIPHARMA-GRADUATES 9  

E-print Network

Programma "LEONARDO DA VINCI" Progetto UNIPHARMA-GRADUATES 9 Bando di Concorso 82 contributi per Programma dell'Unione Europea per l'Apprendimento Permanente ­ Programma settoriale "Leonardo da Vinci CONTRIBUTO LEONARDO DA VINCI (LdV): Il contributo LdV rappresenta un rimborso delle spese di viaggio

Guidoni, Leonardo

77

APLICAO DA ANLISE EXPLORATRIA PARA AVALIAO DA DIFERENCIAO DE ALIMENTOS PRODUZIDOS  

E-print Network

APLICA��O DA ANÁLISE EXPLORAT�RIA PARA AVALIA��O DA DIFERENCIA��O DE ALIMENTOS PRODUZIDOS orgânica e a expansão do consumo de alimentos assim produzidos. A área cultivada com produtos produzidos. As exportações do setor crescem a taxas de 50% ao ano. Nesse contexto, a indústria de alimentos necessita cada

Ferreira, Márcia M. C.

78

EDITAL 003/POSJOR/2013 RESULTADO DA PRIMEIRA FASE DA SELEO 2013  

E-print Network

FILHO 4. CAMILE CARVALHO NASCIMENTO 5. CLAUDIA DE CONTO 6. DANIELA DE OLIVEIRA SOARES 7. DANIELLE ANTONIO NEIVA 24. S�NIA REGINA DA SILVA 25. TÁSSIA BECKER ALEXANDRE 26. THIAGO AMORIM CAMINADA 27 para a arguição da Terceira Fase: TER�A-FEIRA, DIA 21/05/2013 SALA 141 CLAUDIA DE CONTO Das 14h às 14h

Floeter, Sergio Ricardo

79

MINISTRIO DA EDUCAO UNIVERSIDADE FEDERAL DO PARAN  

E-print Network

Enoc Ferreira da Silva E-mail: comercial01@interjet.com.br / contato@interjet.com.br 2 1-Naftol P. Nº referência química CAS 127-09-3, frasco de 1kg ­Marca: Exodo 150 32,00 Rei-Labor Comércio de-4773 Representante: Reinaldo Oliveira Alves E-mail: reilabor@uol.com.br 6 Acetona (aspecto físico líquido límpido

Paraná, Universidade Federal do

80

Ministrio da Educao UNIVERSIDADE FEDERAL DO PARAN  

E-print Network

Ministério da Educação UNIVERSIDADE FEDERAL DO PARANÁ Pró - Reitoria de Gestão de Pessoas Coordenadoria de Desenvolvimento de Pessoas Unidade de Capacitação de Pessoas SOLICITA��O DE CERTIFICADO DE. Preencher e assinar o formulário. 2. Entregar na CDP/UCAP ­ Unidade de Capacitação de Pessoas ou encaminhar

Paraná, Universidade Federal do

81

Ministrio da Educao UNIVERSIDADE FEDERAL DO PARAN  

E-print Network

Ministério da Educação UNIVERSIDADE FEDERAL DO PARANÁ Pró-Reitoria de Gestão de Pessoas EDITAL N de trabalho de Dedicação Exclusiva, a seguir discriminado: Pró-Reitoria de Gestão de Pessoas Gabinete.039465/2013-13 Número de vagas: 05 (cinco), sendo 01 (uma) vaga reservada para pessoas portadoras de deficiência

Paraná, Universidade Federal do

82

Ministrio da Educao UNIVERSIDADE FEDERAL DO PARAN  

E-print Network

Ministério da Educação UNIVERSIDADE FEDERAL DO PARANÁ Pró-Reitoria de Gestão de Pessoas EDITAL N Conhecimento: Ciências Sociais Aplicadas - Administração Matéria Específica: Gestão de Pessoas e Marketing 7,44 Curitiba, 01 de julho de 2014. Adriano do Rosário Ribeiro Pró-Reitor de Gestão de Pessoas #12;

Paraná, Universidade Federal do

83

MINISTRIO DA EDUCAO UNIVERSIDADE FEDERAL DO PARAN  

E-print Network

pesquisa: análise de discurso, métodos qualitativos (etnografia, entrevistas em profundidade, grupos de transição política. Teoria Política I 60 4 Ementa: Textos clássicos fundadores da Ciência Política contemporânea. Confere-se especial atenção às teorias políticas elaboradas por Karl Marx, Max Weber e pelos

Paraná, Universidade Federal do

84

Ministrio da Educao Universidade Federal do Paran  

E-print Network

EVA (coloridos) fita crepe fita dupla face giz de cera giz para lousa e quadro grampeador jogo de alfabeto ilustrado jogo de fantoches de animais (com 10 peças) jogo de fantoches família branca (com 6 peças) jogo de mico de palavras jogo na área da matemática jogos de memória (diversos) jogos

Paraná, Universidade Federal do

85

The Real Code of Leonardo da Vinci  

PubMed Central

Leonardo da Vinci was born in Italy. Among the researchers and scientists, he is favourably known for his remarkable efforts in scientific work. His investigations of atherosclerosis judiciously combine three separate fields of research. In 1506, he finished his masterpiece, painting of Mona Lisa. A careful clinical examination of the famous painting reveals a yellow irregular leather-like spot at the inner end of the left upper eyelid and a soft bumpy well-defined swelling of the dorsum of the right hand beneath the index finger about 3 cm long. This is probably the first case of familial hypercholesterolemia (FH). The FH code of Leonardo da Vinci was given immense consideration by scientists like Carl Muller, who described the xanthomas tuberosum and angina pectoris. On the contrary, Akira Endo searched for microbial metabolites that would inhibit HMG-CoA reductase, the rate-limiting enzyme in the synthesis of cholesterol and finally, Michael Brown and Joseph Goldstein published a remarkable series of elegant and insightful papers in the 70s and 80s. They established that the cellular uptake of low-density lipoprotein (LDL) essentially requires the LDL receptor. In conclusion: this was the real Code of Leonardo da Vinci. PMID:19924278

Ose, Leiv

2008-01-01

86

A computational theory of da Vinci stereopsis.  

PubMed

In binocular vision, occlusion of one object by another gives rise to monocular occlusions—regions visible only in one eye. Although binocular disparities cannot be computed for these regions, monocular occlusions can be precisely localized in depth and can induce the perception of illusory occluding surfaces. The phenomenon of depth perception from monocular occlusions, known as da Vinci stereopsis, is intriguing, but its mechanisms are not well understood. We first propose a theory of the mechanisms underlying da Vinci stereopsis that is based on the psychophysical and computational literature on monocular occlusions. It postulates, among other principles, that monocular areas are detected explicitly, and depth from occlusions is calculated based on constraints imposed by occlusion geometry. Next, we describe a biologically inspired computational model based on this theory that successfully reconstructs depth in a large range of stimuli and produces results similar to those described in the psychophysical literature. These results demonstrate that the proposed neural architecture could underpin da Vinci stereopsis and other stereoscopic percepts. PMID:24914063

Tsirlin, Inna; Wilcox, Laurie M; Allison, Robert S

2014-01-01

87

Qual o Papel da Escola e da Mídia na Obtenção dos Conhecimentos Astronômicos?  

NASA Astrophysics Data System (ADS)

É amplamente reconhecido que as pessoas em geral têm grande fascínio e interesse pela Astronomia. Por outro lado, o conteúdo dessa área incluído no ensino formal está longe de ser abrangente e suficiente para suprir a demanda. Esse interesse permite aperfeiçoar a divulgação e o ensino não formal de Astronomia através da mídia aliando a adequação do conteúdo à expectativa das pessoas. A reforma do Currículo Básico da Escola Pública da maioria dos Estados brasileiros tem introduzido Astronomia desde a pré-escola até o Ensino Médio. Num estudo realizado com 1180 alunos do Ensino Médio de seis escolas estaduais, revelou-se através da aplicação de um formulário contendo questões que abordavam conhecimentos básicos em Astronomia, como foram adquiridos tais conhecimentos e à infra-estrutura da escola. Para 66,1% dos entrevistados o professor já fez alguma apresentação a respeito de Astronomia. O presente estudo revelou também que 54,4% dos alunos entrevistados adquiriram seus conhecimentos astronômicos na escola, 18,4% através da televisão e 27,1% afirmaram que seus conhecimentos foram obtidos através de outros tipos de mídia (internet, livros didáticos, filmes e revistas). Embora o estudo revele claramente que há certo equilíbrio no meio em que os alunos obtiveram seus conhecimentos astronômicos, a mídia busca não somente sua difusão, mas a disponibilização desse conhecimento de maneira correta, que às vezes, não é atingido, apresentando conceitos sem fundamentação e incorretos. Por outro lado, no dia-a-dia escolar, é comum encontrar professores que vêm para as aulas com concepções prévias, que podem diferir substancialmente das idéias a serem ensinadas, dificultando o aprendizado de futuros conceitos científicos. Uma avaliação criteriosa, avaliando as dificuldades dos professores em determinar o sentido correto dos conceitos e observando a metodologia que utilizam no ensino, poderá proporcionar uma melhor compreensão sobre as concepções alternativas, presentes no ensino de Astronomia.

da Cunha, W. S.; Voelzke, M. R.; Amaral, L. H.

2007-08-01

88

Brasil Venezuela: paradiplomacia na integração econômica da área de fronteira.  

E-print Network

??Mediante a pesquisa empreendida, buscou-se estudar aspectos da globalização, integração regional e, em especial, as relações internacionais existentes entre governos não centrais, envolvendo Brasil e… (more)

Almir Morais Sá

2009-01-01

89

MINISTRIO DA EDUCAO UNIVERSIDADE FEDERAL DO PARAN  

E-print Network

refrigerante não deve conter CFC. Silencioso. Tensão 110/127 volts. Marca: Libell- Modelo: Pressbabyinox 100 R Cesar da Silva E-mail: loesch@loesch.com.br 2 Bebedouro de pressão conjugado - gabinetes em aço inox refrigerante não deve conter CFC. Com depósito de água em aço inox com dreno de limpeza silencioso. Tensão 110/127

Paraná, Universidade Federal do

90

MINISTRIO DA EDUCAO UNIVERSIDADE FEDERAL DO PARAN  

E-print Network

verticais com laminas de 9 cm de largura em PVC liso curve, trilho perfil sólido de alumínio anodizado fosco.820.375/0001-59 4490.52.51 3 Persianas verticais, com laminas de 9 cm de largura em PVC liso, na cor manteiga, com rosário em PVC. Todas devem ter reforço de 3 cm na parte da furação das lâminas. Com visita no local 500m2

Paraná, Universidade Federal do

91

Aves Aquáticas da Lagoa da Pampulha: Seleção de hábitats e atividade diurna  

Microsoft Academic Search

Wading birds at Lagoa da Pampulha: Habitat selection and diurnal activity. The wading bird communities in lacunar systems are mainly structured based on the availability and distribution of feeding resources and appropriate conditions for their reproduction and establishment. As a result, in a given habitat, each species selects, according to the possibilities of its behavioral repertoire, the best way to

Flávio E. Pimenta; João C. P. Drummond; Ana C. Lima

92

DIAGNÓSTICO DE FALHAS EM MÁQUINAS ROTATIVAS ATRAVÉS DA ANÁLISE DA VIBRAÇÃO TORCIONAL  

Microsoft Academic Search

RESUMO Os eixos, quando transmitem torque, agem como molas torcionais, além da flexão. Quando há variação cíclica no torque transmitido podem aparecer vibrações torcionais forçadas, que dependendo das freqüências naturais do sistema poderão causar ressonância, caso em que o eixo poderá oscilar em amplitudes suficientemente elevadas para produzir falhas. O presente trabalho apresenta técnicas de medição e análise de vibração

Evaldo Khater

93

A NATUREZA DA CIÊNCIA E A INSTRUMENTAÇÃO PARA O ENSINO DA FÍSICA  

Microsoft Academic Search

Resumo: O propósito deste artigo é o de examinar as convicções filosóficas que dão suporte aos compor- tamentos de alguns professores de física ao lidarem com o ensino da Física no contexto de um laborató- rio. Entrevistas foram feitas com professores de \\

Alexandre Medeiros; Severino Bezerra Filho

2000-01-01

94

OBTENÇÃO DE WOLASTONITA À PARTIR DA CINZA DA CASCA DO ARROZ  

Microsoft Academic Search

RESUMO A wolastonita sintética (CaSiO3) com elevado grau de pureza tem várias aplicações na indústria e agricultura. A cinza da casca do arroz (CCA), pode se tornar verdadeiramente útil na fabricação de diferentes materiais, já que são produzidos em grandes quantidades no país. A alta concentração de sílica na CCA (cerca de 25%) e sua extração com baixo custo e

A. A. Fernandes; E. U. Frajndlich; H. G. Riella

95

Evoluo da Computao de Alto Desempenho na tica da Lista TOP500  

E-print Network

número de processadores, aumentando mais ainda o poder computacional. Veremos a importância da computação computacional, projetar um programa paralelo eficiente. O progresso também deixa a desejar. Conseguimos lidar alta demanda computacional que podem tirar proveito do paralelismo maciço. Criar novos (?) modelos de

Song, Siang Wun

96

Descentralização da Educação Pública no Brasil: Trajetória dos Gastos e das Matrículas  

Microsoft Academic Search

Este trabalho analisa o processo de descentralização da educação pública no Brasil iniciado em meados da década de 1990. O ponto de partida é um resgate histórico da gestão da política educacional brasileira, fortemente ligada às transformações políticas e econômicas da história recente do país. Em seguida, o foco recai sobre o quadro institucional-legal e a estrutura de financiamento e

Jorge Abrahão de Castro; Bruno de Carvalho Duarte

2008-01-01

97

Linguateca: um Centro de Recursos Distribuído para o Processamento Computacional da Língua Portuguesa  

Microsoft Academic Search

Resumo. Neste artigo apresentamos uma panorâmica da actividade da Linguateca na criação e disponibilização de recursos e ferramentas para a língua portuguesa. Começamos por uma descrição dos objectivos e pressupostos da Linguateca e uma breve história da sua intervenção, e finalizamos com algumas considerações sobre a melhor forma de prosseguir na organização da área.

Diana Santos; Alberto Simões; Anabela Barreiro; Belinda Maia; Cristina Mota; Débora Oliveira; Eckhard Bick; Elisabete Ranchhod; José João Dias de Almeida; Luís Cabral; Luís Costa; Luís Sarmento; Marcirio Chaves; Nuno Cardoso; Paulo Rocha; Rachel Aires; Rosário Silva; Rui Vilela; Susana Afonso

2004-01-01

98

Crnica I Encontro Solar na UDC O pasado mrcores 24 de abril tivo lugar na Praza da Fraga (Campus da  

E-print Network

a exposición de aparellos solares instalada na Praza da Fraga, dende cociñas e fornos, ate cargadores para oCrónica I Encontro Solar na UDC O pasado mércores 24 de abril tivo lugar na Praza da Fraga (Campus da Zapateira) a primeira edición do Encontro Solar na UDC. Esta era a terceira das actividades

Fraguela, Basilio B.

99

O sentido originário da Verdade: Heidegger com Aristóteles 1  

Microsoft Academic Search

O tema da verdade, em Heidegger, é bastante caro para o desenvolvimento de sua filosofia. A crítica contumaz da metafísica empreendida por Heidegger enquanto história do esquecimento do ser somente se tornou possível devido à sua intuição originária com respeito ao problema que a mesma suscita em relação à questão do ser e do sentido que se mostra como. Heidegger

Alexandre Rubenich

2009-01-01

100

The Case: Bunche-Da Vinci Learning Partnership Academy  

ERIC Educational Resources Information Center

The Bunche-Da Vinci case described in this article presents a situation at Bunche Elementary School that four theorists were asked to address in their evaluation designs (see EJ791771, EJ719772, EJ791773, and EJ792694). The Bunche-Da Vinci Learning Partnership Academy, an elementary school located between an urban port city and a historically…

Eisenberg, Nicole; Winters, Lynn; Alkin, Marvin C.

2005-01-01

101

DA-6034 Induces [Ca2+]i Increase in Epithelial Cells  

PubMed Central

DA-6034, a eupatilin derivative of flavonoid, has shown potent effects on the protection of gastric mucosa and induced the increases in fluid and glycoprotein secretion in human and rat corneal and conjunctival cells, suggesting that it might be considered as a drug for the treatment of dry eye. However, whether DA-6034 induces Ca2+ signaling and its underlying mechanism in epithelial cells are not known. In the present study, we investigated the mechanism for actions of DA-6034 in Ca2+ signaling pathways of the epithelial cells (conjunctival and corneal cells) from human donor eyes and mouse salivary gland epithelial cells. DA-6034 activated Ca2+-activated Cl- channels (CaCCs) and increased intracellular calcium concentrations ([Ca2+]i) in primary cultured human conjunctival cells. DA-6034 also increased [Ca2+]i in mouse salivary gland cells and human corneal epithelial cells. [Ca2+]i increase of DA-6034 was dependent on the Ca2+ entry from extracellular and Ca2+ release from internal Ca2+ stores. Interestingly, these effects of DA-6034 were related to ryanodine receptors (RyRs) but not phospholipase C/inositol 1,4,5-triphosphate (IP3) pathway and lysosomal Ca2+ stores. These results suggest that DA-6034 induces Ca2+ signaling via extracellular Ca2+ entry and RyRs-sensitive Ca2+ release from internal Ca2+ stores in epithelial cells. PMID:24757369

Yang, Yu-Mi; Park, Soonhong; Ji, HyeWon; Kim, Tae-im; Kim, Eung Kweon; Kang, Kyung Koo

2014-01-01

102

Dilemas Teóricos no Processo de Construção da Cultura Organizacional  

Microsoft Academic Search

Resumo Considerada uma das problemáticas mais estudadas no domínio da sociologia das organizações, a cultura organizacional padece, contudo, de um déficit de reflexão sobre as suas raízes teórico-disciplinares. Apesar de várias investidas na análise da sua génese e evolução histórica, não se conhecem estudos focalizados na abordagem das condições de produção desta problemática e no debate sobre os sentidos teóricos

Leonor Lima Torres

103

O aproveitamento da energia eolica (The wind energy resource)  

Microsoft Academic Search

Diversos estudos realizados nosultimos anos tem apontado as implicacoes e impactos socio-ambientais do consumo de energia. As fontes renovaveis de energia sao apresentadas como a principal alternativa para atender as demandas da sociedade com relacaoa qualidade e seguranca do atendimento da demanda de eletricidade com a reducao dos danos ambientais decorrentes do consumo de energia. Este artigo apresenta uma revisao

F. R. Martins; R. A. Guarnieri; E. B. Pereira

104

Berengario da Carpi: a pioneer in neurotraumatology.  

PubMed

Berengario da Carpi was one of the most famous physicians of the 16th century, a recognized master of anatomy and surgery, an emblematic "Renaissance man" who combined his medical experience and engineering knowledge to design new surgical instruments, and effectively used the arts of writing and drawing to describe state-of-the-art medicine and provide illustrations of anatomical structures. His greatest contribution to medicine was to write the most important work on craniocerebral surgery of the 16th century, the Tractatus de Fractura Calvae sive Cranei (Treatise on Fractures of the Calvaria or Cranium), in which he described an entire set of surgical instruments to be used for cranial operations to treat head traumas that became a reference for later generations of physicians. This was a systematic treatise covering the mechanisms, classification, and medical and surgical treatment of head traumas, and can be considered a milestone in the history of neurotraumatology. PMID:21128734

Di Ieva, Antonio; Gaetani, Paolo; Matula, Christian; Sherif, Camillo; Skopec, Manfred; Tschabitscher, Manfred

2011-05-01

105

Leonardo da Vinci's contributions to neuroscience.  

PubMed

Leonardo da Vinci (1452-1519) made far-reaching contributions to many areas of science, technology and art. Leonardo's pioneering research into the brain led him to discoveries in neuroanatomy (such as those of the frontal sinus and meningeal vessels) and neurophysiology (he was the first to pith a frog). His injection of hot wax into the brain of an ox provided a cast of the ventricles, and represents the first known use of a solidifying medium to define the shape and size of an internal body structure. Leonardo developed an original, mechanistic model of sensory physiology. He undertook his research with the broad goal of providing physical explanations of how the brain processes visual and other sensory input, and integrates that information via the soul. PMID:11998691

Pevsner, Jonathan

2002-04-01

106

Respostas religiosas à aids no Brasil: impressões de pesquisa acerca da Pastoral de DST/Aids da Igreja Católica1  

PubMed Central

O texto encontra-se estruturado em quatro partes. Na primeira delas, apresentamos um conjunto de considerações e informações acerca da situação da aids no Brasil, das relações entre religião, sexualidade, aids e estado laico, bem como uma descrição mais clara do Projeto Respostas Religiosas ao HIV/Aids no Brasil, do qual este texto apresenta algumas impressões de pesquisa preliminares. A seguir, dedicamos um item a apresentação da Pastoral de DST/Aids, sua história, estrutura e objetivos. No item seguinte problematizamos diversas questões em particular no âmbito das relações Estado e Igreja, relações entre agentes de pastoral e hierarquia da Igreja, e questões ligadas mais diretamente à sexualidade e aids, todas referenciadas ao trabalho da Pastoral de DST/Aids. Ao final, apresentamos a bibliografia e fontes consultadas. PMID:20442806

Seffner, Fernando; Silva, Cristiane Gonçalves Meireles da; Maksud, Ívia; Garcia, Jonathan; Rios, Luís Felipe; Natividade, Marcelo; Borges, Priscila Rodrigues; Parker, Richard; Terto, Veriano

2009-01-01

107

Metal Lines in DA White Dwarfs  

NASA Astrophysics Data System (ADS)

We report Keck telescope HIRES echelle observations of DA white dwarfs in a continuation of an extensive search for metals. These spectra are supplemented with new JHK magnitudes that are used to determine improved atmospheric parameters. Of the DA white dwarfs not in binary or common proper motion systems, about 25% show Ca II lines. For these, Ca abundances are determined from comparison with theoretical equivalent widths from model atmosphere calculations; in a few cases we also obtain Mg, Fe, Si, and Al abundances. If Ca is not observed, we generally determine very stringent upper limits. We compare the data to predictions of previously published models involving the accretion/diffusion of interstellar matter and of comets. The derived abundances are not obviously compatible with the predictions of either model, which up to now could only be tested with traces of metals in helium-rich white dwarfs. By modifying certain assumptions in the published interstellar accretion model we are able to match the distribution of the elements in the white dwarf atmospheres, but, even so, tests of other expectations from this scenario are less successful. Because comet accretion appears unlikely to be the primary cause of the DAZ phenomenon, the data suggest that no more than about 20% of F-type main-sequence stars are accompanied by Oort-like comet clouds. This represents the first observational estimate of this fraction. A plausible alternative to the accretion of cometary or interstellar matter is disruption and accretion of asteroidal material, a model first suggested in 1990 to explain excess near-infrared emission from the DAZ G29-38. An asteroidal debris model to account for the general DAZ phenomenon does not presently disagree with the HIRES data, but neither is there any compelling evidence in support of such a model. The HIRES data indicate that in close red dwarf/white dwarf binaries not known to be cataclysmic variables there is, nonetheless, significant mass transfer, perhaps in the form of a wind flowing off the red dwarf. As a by-product we find from the kinematics of GD 165 a likely age of more than 2 Gyr for its probable brown dwarf companion GD 165B. This paper is based in part on observations obtained at the Calar Alto Observatory of the Deutsch-Spanisches Astronomisches Zentrum and at the W. M. Keck Observatory, which is operated as a scientific partnership among the California Institute of Technology, the University of California, and NASA. The Observatory was made possible by the generous financial suppport of the W. M. Keck Foundation. We have made use of the SIMBAD database at CDS.

Zuckerman, B.; Koester, D.; Reid, I. N.; Hünsch, M.

2003-10-01

108

A (Des)Razão no Transcurso da Modernidade: Apontamentos Relativos à Teoria Crítica  

Microsoft Academic Search

Este artigo faz parte de uma investigação maior desenvolvida no âmbito do Doutoramento em Ciências da Comunicação. No mesmo procura-se mostrar como dois dos mais destacados representantes da teoria crítica, nomeadamente Theodor Adorno e Max Horkheimer, analisaram o «progresso regressivo» da modernidade. Para estes autores, o mesmo, indiciando as contradições mediadoras da experiência moderna que é nossa, consubstanciava uma prova

Manuel Menezes

109

UNIVERSIDADE FEDERAL DE SANTA CATARINA CENTRO DE CINCIAS DA SADE  

E-print Network

de Freitas, Alacoque Erdmann, Lenilza Mattos Lima e-mails: sergio.freitas@ufsc.br; alacoque.erdmann@ufsc.br; lenilza.mattos@ufsc.br. Ementa: Estrutura político-administrativa da UFSC e do CCS. Plano de carreira

Floeter, Sergio Ricardo

110

Organizzato da: Christopher Smith, British School at Rome  

E-print Network

Organizzato da: Christopher Smith, British School at Rome Attilio Mastrocinque, Università di LIPPOLIS, Attilio MASTROCINQUE, Christopher SMITH - Presentazione 10.00 ­ 10.30 Elio LO CASCIO - I fora e

Guidoni, Leonardo

111

Seo 312 Reitoria /Tcnico-Administrativos Local: Auditrio da Reitoria  

E-print Network

DUARTE FILHO REITORIA-servidor 312 ADRIANA REGINA C.ESPINDOLA KOBIYAMA REITORIA-servidor 312 ADRIANE-servidor 312 ALINE MARIA VIEIRA DA COSTA REITORIA-servidor 312 ALITA DIANA CORREA KUCHLER REITORIA-servidor 312

Floeter, Sergio Ricardo

112

Ris-R-1349(DA) Forskning i Aeroelasticitet EFP-2001  

E-print Network

Risø-R-1349(DA) Forskning i Aeroelasticitet EFP-2001 Redigeret af Helge Aagaard Madsen for Forskning i Aeroelasticitet ­ EFP-2001", gennemført i et samarbejde mellem Risø, DTU og vindmølleindustrien

113

40 CFR 60.52Da - Recordkeeping requirements.  

Code of Federal Regulations, 2013 CFR

...Performance for Electric Utility Steam Generating Units § 60.52Da Recordkeeping requirements...visible emission observer opacity field data sheets; (2) For each performance...visible emission observer opacity field data sheets; and (iv)...

2013-07-01

114

40 CFR 60.52Da - Recordkeeping requirements.  

Code of Federal Regulations, 2012 CFR

...Performance for Electric Utility Steam Generating Units § 60.52Da Recordkeeping requirements...visible emission observer opacity field data sheets; (2) For each performance...visible emission observer opacity field data sheets; and (iv)...

2012-07-01

115

40 CFR 60.52Da - Recordkeeping requirements.  

Code of Federal Regulations, 2014 CFR

...Performance for Electric Utility Steam Generating Units § 60.52Da Recordkeeping requirements...visible emission observer opacity field data sheets; (2) For each performance...visible emission observer opacity field data sheets; and (iv)...

2014-07-01

116

MIGRATION FROM OPC-DA TO OPC-UA  

E-print Network

The OPC-DA specification of OPC has been a highly successful interoperability standard for process automation since 1996, allowing communications between any compliant components regardless of vendor. CERN has a reliance on OPC-DA Server implementations from various 3rd party vendors which provide a standard interface to their hardware. The OPC foundation finalized the OPC-UA specification and OPC-UA implementations are now starting to gather momentum. This paper gives a brief overview of the headline features of OPC-UA and a comparison with OPC-DA and outlines the necessity of migrating from OPC-DA and the motivaion for migraing to OPC-UA. Feedback from research into the avaiblability of tools and testing utilities will be presented and a practical overview of what will be required from a computing perspecive in order to run OPC-UA clients and servers in the CERN network.

Farnham, B

2011-01-01

117

Leonardo da Vinci: Founder of the science of geological facies  

Microsoft Academic Search

Existing ideas on the history of geology are refined. It is shown that Leonardo da Vinci is the founder of the science of geological facies. His principal geological concepts, which passed several centuries ahead of time, are discussed.

M. G. Berger

2005-01-01

118

Tree Branching: Leonardo da Vinci's Rule versus Biomechanical Models  

PubMed Central

This study examined Leonardo da Vinci's rule (i.e., the sum of the cross-sectional area of all tree branches above a branching point at any height is equal to the cross-sectional area of the trunk or the branch immediately below the branching point) using simulations based on two biomechanical models: the uniform stress and elastic similarity models. Model calculations of the daughter/mother ratio (i.e., the ratio of the total cross-sectional area of the daughter branches to the cross-sectional area of the mother branch at the branching point) showed that both biomechanical models agreed with da Vinci's rule when the branching angles of daughter branches and the weights of lateral daughter branches were small; however, the models deviated from da Vinci's rule as the weights and/or the branching angles of lateral daughter branches increased. The calculated values of the two models were largely similar but differed in some ways. Field measurements of Fagus crenata and Abies homolepis also fit this trend, wherein models deviated from da Vinci's rule with increasing relative weights of lateral daughter branches. However, this deviation was small for a branching pattern in nature, where empirical measurements were taken under realistic measurement conditions; thus, da Vinci's rule did not critically contradict the biomechanical models in the case of real branching patterns, though the model calculations described the contradiction between da Vinci's rule and the biomechanical models. The field data for Fagus crenata fit the uniform stress model best, indicating that stress uniformity is the key constraint of branch morphology in Fagus crenata rather than elastic similarity or da Vinci's rule. On the other hand, mechanical constraints are not necessarily significant in the morphology of Abies homolepis branches, depending on the number of daughter branches. Rather, these branches were often in agreement with da Vinci's rule. PMID:24714065

Minamino, Ryoko; Tateno, Masaki

2014-01-01

119

Thirty-Five New Pulsating DA White Dwarf Stars  

Microsoft Academic Search

We present 35 new pulsating DA (hydrogen atmosphere) white dwarf stars discovered from the Sloan Digital Sky Survey (SDSS) and the Hamburg Quasar Survey (HQS). We have acquired high-speed time series photometry of preselected DA white dwarfs with a prime focus CCD photometer on the 2.1 m telescope at McDonald Observatory over 15 months. We selected these stars on the

F. Mullally; R. E. Nather; D. E. Winget; Ted von Hippel; S. J. Kleinman; Atsuko Nitta; Jurek Krzesinski; S. O. Kepler; A. Kanaan; D. Koester; D. J. Sullivan; D. Homeier; S. E. Thompson; D. Reaves; C. Cotter; D. Slaughter; J. Brinkmann

2004-01-01

120

Introduc ~ao `a Teoria da Medida e Integral de Lebesgue  

E-print Network

Introduc¸ ~ao `a Teoria da Medida e Integral de Lebesgue Primeira Edi¸c~ao V0.95 Agosto de 2013 introdu¸c~ao curta `a Teoria da Medida. Os pr´e-requisitos s~ao: (a) Teoria (elementar) dos conjuntos; (b as defini¸c~oes. Quanto ao conte´udo selecionado, apresentamos a Teoria Geral de Medida, sem nos restrin

Cabral, Marco

121

FLIR image segmentation based on DA-GMRF model  

Microsoft Academic Search

In order to conquer the drawback of over-smoothness in the MRF model, a kind of discontinuity-adaptive Gaussian Markov random field (DA-GMRF) model is defined, in which the edge information of image is used to construct corresponding energy functions. After this a FLIR image segmentation method based on DA-GMRF model is proposed, which includes initialization and optimization of the label field.

Lin Qi; Zelin Shi

2007-01-01

122

Desconstrução da metafísica da linguagem e retradução dos capítulos 1, 2 e 3 do "Des Mots" de Leibniz.  

E-print Network

??Dissertação (mestrado)—Universidade de Brasília, Instituto de Letras, Departamento de Línguas Estrangeiras e Tradução, Programa de Pós-Graduação em Estudos da Tradução, 2014 À luz do pensamento… (more)

Silva, Juliana Cecci

2014-01-01

123

VII Seminrio Informal(, mas Formal!) do Grupo de Teoria da Computao da UnB -GTC/UnB  

E-print Network

VII Seminário Informal(, mas Formal!) do Grupo de Teoria da Computação da UnB - GTC/UnB Apoio teorias equacionais AC convergentes, Daniele Nantes Sobrinho (Doutoranda), Departamento de Matemática Teoria para Unificação de Primeira Ordem em PVS, Andréia Borges (Mestranda), Departamento de Matemática

Ayala-Rincón, Mauricio

124

A cosmologia no ensino da geografia  

NASA Astrophysics Data System (ADS)

O principal objetivo deste trabalho é auxiliar o professor de Geografia em sala de aula no ensino de tópicos relacionados com a Cosmologia. A idéia deste trabalho surgiu quando foi constatado que o professor de Geografia tem dificuldades de ensinar este tópico. Esta constatação foi feita por uma das autoras ao lecionar este tópico no ensino fundamental e em discussões com outros professores de Geografia. Da mesma maneira que ocorria desde os tempos mais antigos, os alunos têm muito interesse em conhecer os fenômenos que ocorrem no Cosmo, porém os livros didáticos de Geografia utilizados em sala de aula não são ricos em informações sobre este assunto. Assim, o professor de Geografia tem poucas informações para discutir este assunto em sala de aula e não dá a devida importância para este tópico. Então, foi desenvolvido um material de apoio para professores de Geografia sobre a origem do Universo, sua evolução e seu possível futuro evolutivo segundo as mais recentes teorias, com base em perguntas feitas pelos alunos de ensino fundamental e as informações trazidas nos livros didáticos Não cabe a este material inovar e tão pouco trazer uma metodologia de ensino de Cosmologia. Neste material o professor de Geografia pode encontrará um banco de informações, que constitui no estabelecimento de conceitos, teorias e hipóteses, sobre a Cosmologia, em linguagem simples e de fácil entendimento. Para desenvolvê-lo, foram feitas pesquisas não exaustivas em livros e revistas científicas, compilação e discussão em forma cronológica das teorias aceitas sobre modelos cosmológicos. Portanto, este material será apresentado neste trabalho.

Santos, S. C.; Chiaradia, A. P. M.

2003-08-01

125

A filosofia da tolerncia (O conceito de quase verdade de Newton da Costa), Folha de So Paulo, 30 de novembro de 1997, Caderno Mais n5, 7.  

E-print Network

1 A filosofia da tolerância (O conceito de quase verdade de Newton da Costa), Folha de São Paulo, 30 de novembro de 1997, Caderno Mais n°5, 7. A filosofia da tolerância (O conceito de quase verdade de Newton da Costa) MICHEL PATY Com seu último livro, publicado agora pela Discurso editorial (São

Paris-Sud XI, Université de

126

The ATLAS PanDA Monitoring System and its Evolution  

NASA Astrophysics Data System (ADS)

The PanDA (Production and Distributed Analysis) Workload Management System is used for ATLAS distributed production and analysis worldwide. The needs of ATLAS global computing imposed challenging requirements on the design of PanDA in areas such as scalability, robustness, automation, diagnostics, and usability for both production shifters and analysis users. Through a system-wide job database, the PanDA monitor provides a comprehensive and coherent view of the system and job execution, from high level summaries to detailed drill-down job diagnostics. It is (like the rest of PanDA) an Apache-based Python application backed by Oracle. The presentation layer is HTML code generated on the fly in the Python application which is also responsible for managing database queries. However, this approach is lacking in user interface flexibility, simplicity of communication with external systems, and ease of maintenance. A decision was therefore made to migrate the PanDA monitor server to Django Web Application Framework and apply JSON/AJAX technology in the browser front end. This allows us to greatly reduce the amount of application code, separate data preparation from presentation, leverage open source for tools such as authentication and authorization mechanisms, and provide a richer and more dynamic user experience. We describe our approach, design and initial experience with the migration process.

Klimentov, A.; Nevski, P.; Potekhin, M.; Wenaus, T.

2011-12-01

127

1991 DA: An asteroid in a bizarre orbit  

NASA Technical Reports Server (NTRS)

Asteroidal object 1991 DA has an orbit of high inclination, crossing the planets from Mars to Uranus. This is unique for an asteroid, but not unusual for a comet of the Halley-type: it therefore seems likely that 1991 DA is an extinct or dormant comet. Previous CCD imaging has shown no indication of a coma; spectroscopic observations of 1991 DA which lack any evidence of strong comet-like emissions are reported. Numerical integrations of the orbit of this object were performed which show that is has been remarkably stable for the past approximately 20,000 yr, but chaotic before that. This may allow a new estimate to be made of the physical lifetimes of comets.

Steel, Duncan; Mcnaught, Robert H.; Asher, David

1992-01-01

128

Resolvendo a equação de Schrödinger através da substituição direta da série de potências  

E-print Network

This work presents a direct and highly accurate method to solve ordinary differential equations, in particular the Schr\\"odinger equation in one dimension, through the direct substitution of a power series solution to obtain a purely algebraical system containing the recurrence relations among the series coefficients. With these recurrence relations at hand it is possible to build an extremely simple routine using only basic arithmetic operations to find solutions of very high accuracy at a very low cost of machine resources. For the Schr\\"odinger equation the energy eigenvalues may be estimated by a very simple method, an this estimate may be easily refined using the recurrence relations until the specified tolerance has been reached, which allows one to find high accuracy wavefunctions even for states with very high quantum numbers. ----- Este trabalho apresenta um m\\'etodo direto e de alta acur\\'acia para resolver equa\\c{c}\\~oes diferenciais ordin\\'arias, em particular a equa\\c{c}\\~ao de Schr\\"odinger em uma dimens\\~ao, atrav\\'es da substitui\\c{c}\\~ao direta de uma solu\\c{c}\\~ao em s\\'erie de pot\\^encias para obter um sistema puramente alg\\'ebrico contendo as rela\\c{c}\\~oes de recorr\\^encia entre os coeficientes da s\\'erie. De posse dessas rela\\c{c}\\~oes de recorr\\^encia \\'e poss\\'ivel construir uma rotina extremamente simples, usando somente opera\\c{c}\\~oes aritm\\'eticas b\\'asicas, para encontrar solu\\c{c}\\~oes de alt\\'issima acur\\'acia a um custo muito reduzido de recursos de m\\'aquina. Para a equa\\c{c}\\~ao de Schr\\"odinger, os autovalores de energia podem ser estimados por um m\\'etodo simples, e a estimativa pode ser facilmente refinada com o uso das rela\\c{c}\\~oes de recorr\\^encia at\\'e que se alcance a toler\\^ancia especificada, o que permite encontrar fun\\c{c}\\~oes de onda de alta acur\\'acia mesmo para estados com n\\'umero qu\\^antico alto.

Fabio E. R. Campolim

2014-09-24

129

Resolucin do 21 de novembro de 2013 da Universidade da Corua, pola que se fixa o procedemento e o prazo de presentacin das solicitudes de avaliacin da actividade  

E-print Network

Facultade de Ciencias do Deporte e a Educación Física e o profesorado contratado por tempo indefinido dereito ao persoal funcionario numerario pertencente á Facultade de Ciencias do Deporte e a Educación numerario da Facultade de Ciencias do Deporte e a Educación Física desta Universidade que posúa o título de

Fraguela, Basilio B.

130

Identification of a 13-kDa protein associated with the polyhydroxyalkanoic acid granules from Acinetobacter spp  

Microsoft Academic Search

Proteins associated with poly-?-hydroxybutyrate (PHB) granules were purified from four Acinetobacter strains isolated from modified activated sludge treatment plants. Four predominant proteins of 64 kDa, 41 kDa, 38 kDa and 13 kDa were identified. N-terminal amino acid sequencing of the 64-kDa and 13-kDa proteins from Acinetobacter RA3849 identified these proteins as the products of the phaCAc and phaPAc (formerly designated

Mark A. Schembri; Alan A. Woods; Ronald C. Bayly; John K. Davies

1995-01-01

131

Expression and purification of the angiogenesis inhibitor 16-kDa prolactin fragment from insect cells  

Microsoft Academic Search

The 16-kDa fragment of prolactin (16-kDa PRL), derived from proteolytic cleavage of 23-kDa PRL, was shown to have antiangiogenic activity. Previous studies have shown that recombinant 16-kDa PRL produced from bacteria often contained endotoxins, which are cytotoxic to endothelial cells, and varied in its biological activity due to changes in its refolding from inclusion bodies. These problems limited the use

Matthew Galfione; Weiping Luo; Jeri Kim; David Hawke; Ryuji Kobayashi; Carmen Clapp; Li-Yuan Yu-Lee; Sue-Hwa Lin

2003-01-01

132

Intramembrane translocation and posttranslational palmitoylation of the chloroplast 32-kDa herbicide-binding protein  

Microsoft Academic Search

The 32-kDa herbicide-binding protein, a component of photosystem II, is synthesized as a membrane-associated 33.5-kDa precursor within the chloroplast. We show that membrane attachment of the precursor and processing to the 32-kDa form occur in the unstacked stromal lamellae. Once processed, the 32-kDa protein translocates, within the thylakoids, to the topologically distinct stacked granal lamellae. Posttranslational palmitoylation of the processed

A. K. Mattoo; M. Edelman

1987-01-01

133

The Potential da Vinci in All of Us  

ERIC Educational Resources Information Center

The study of the human form is fundamental to both science and art curricula. For vertebrates, perhaps no feature is more important than the skeleton to determine observable form and function. As Leonard da Vinci's famous Proportions of the Human Figure (Virtruvian Man) illustrates, the size, shape, and proportions of the human body are defined by…

Petto, Sarah; Petto, Andrew

2009-01-01

134

SOBRE AS SIGNIFICAES JURDICAS DA RESPONSABILIDADE POLTICA* Eric Millard*  

E-print Network

diversos livros e artigos jurídicos. halshs-00126323,version1-24Jan2007 Author manuscript, published ciência, toda filosofia é, inicialmente, uma crítica da língua. A língua de uma ciência não é a língua

Paris-Sud XI, Université de

135

ISSN 0103-9741 Monografias em Cincia da Computao  

E-print Network

.3 Desenvolvimento de Software Orientado a Aspectos . . . . . . . . . . . . . . 2 2.4 Aspect especíco da NASA e que faz parte de um dos trabalhos aqui relaciona- dos. Contudo foram exploradas-PLs, allowing runtime product derivation. As a Case- Study, it has been reused NASA Projects for ANTs

Endler, Markus

136

ISSN 0103-9741 Monografias em Cincia da Computao  

E-print Network

into cells from all three germinal layers while multipotent stem cells can generate only closely relatedISSN 0103-9741 Monografias em Ciência da Computação n° 04/09 Automatic Embryonic Stem Cells de Lucena February, 2009 Automatic Embryonic Stem Cells Detection and Counting in Fluorescence

Endler, Markus

137

Visualization Queries Nicholas Del Rio and Paulo Pinheiro da Silva  

E-print Network

Visualization Queries Nicholas Del Rio and Paulo Pinheiro da Silva The University of Texas at El the notion of a query that describes a visualization request in terms of a universe of concepts, which on these concepts, users may be able to request for what properties they want to see in their visualizations (i

Ward, Karen

138

Theoretical models for asteroseismology of DA white dwarf stars  

Microsoft Academic Search

Because white dwarfs are the most common end state of stellar evolution, determining their internal structure will yield many clues about the final stages of stellar evolution and the physics of matter under extreme conditions. We present the results of our parametric survey of evolutionary models of compositionally stratified white dwarfs with hydrogen surface layers (DA white dwarfs) and provide

P. A. Bradley

1996-01-01

139

2014 D.A. Menasce. All Rights Reserved. Autonomic Computing  

E-print Network

© 2014 D.A. Menasce. All Rights Reserved. 1 Autonomic Computing: a new design principle for complex Rights Reserved. 5 #@*%#! #12;Outline · Motivation for Autonomic Computing · Techniques used in AC ­ Model-driven · Performance model · Control theory ­ Model-free · Machine learning (e.g., reinforcement

Menascé, Daniel A.

140

Training and Health. Leonardo da Vinci Series: Good Practices.  

ERIC Educational Resources Information Center

This document profiles programs in the fields of health and medicine that are offered through the European Commission's Leonardo da Vinci program. The following programs are profiled: (1) CYTOTRAIN (a transnational vocational training program in cervical cancer screening); (2) Apollo (a program of open and distance learning for paramedical…

Commission of the European Communities, Brussels (Belgium). Directorate-General for Education and Culture.

141

Women and Technical Professions. Leonardo da Vinci Series: Good Practices.  

ERIC Educational Resources Information Center

This document profiles programs for women in technical professions that are offered through the European Commission's Leonardo da Vinci program. The following programs are profiled: (1) Artemis and Diana (vocational guidance programs to help direct girls toward technology-related careers); (2) CEEWIT (an Internet-based information and…

Commission of the European Communities, Brussels (Belgium). Directorate-General for Education and Culture.

142

Studying and Working Abroad. Leonardo da Vinci Series: Good Practices.  

ERIC Educational Resources Information Center

This document profiles recent successful examples of students studying and working abroad as part of the European Commission's Leonardo da Vinci program, which is designed to give students across the European Union the opportunity to experience vocational training in a foreign country. The following examples are presented: (1) 3 Finnish students…

Commission of the European Communities, Brussels (Belgium). Directorate-General for Education and Culture.

143

UNIVERSIDADE FEDERAL DE SANTA CATARINA CENTRO DE CINCIAS DA SADE  

E-print Network

, brasileiros ou estrangeiros residentes no Brasil, de acordo com critérios que seguem. #12;II - PERÍODO, FORMAS reconhecida pelo MEC. f) Cópias autenticadas da cédula de identidade e do CPF. Se estrangeiro, cópia do visto

Floeter, Sergio Ricardo

144

A Relao entre Teoria, Postulados, Hipteses e a Natureza da  

E-print Network

A Relação entre Teoria, Postulados, Hipóteses e a Natureza da Investigação Científica #12;Conhecimento (Teorias) Explicação Científica Hipótese Científica Modelo Estatístico Hipótese Estatística Dados

Paiva, Paulo Cesar de

145

INOVAÇÃO E TEORIAS DA FIRMA EM TRÊS PARADIGMAS  

Microsoft Academic Search

1. INTRODUÇÃO Desde os tempos de Alfred Marshall, a teoria econômica procura criar mo- delos que capturem a lógica do comportamento das firmas e dos merca- dos. Os resultados destes esforços não resultaram em um quadro analítico convergente, já que persistem controvérsias importantes acerca do papel das diferentes forças que influenciam o crescimento e os objetivos da firma. Winter (1993),

Paulo Bastos Tigre

146

ISTITUTO ITALIANO PER GLI STUDI STORICI fondato da Benedetto Croce  

E-print Network

ISTITUTO ITALIANO PER GLI STUDI STORICI fondato da Benedetto Croce Palazzo Filomarino -Via B@iiss.it Concorso a borse di studio per l'anno accademico 2014-2015 L'Istituto Italiano per gli Studi Storici sottoscritte, dovranno pervenire all'Istituto italiano per gli studi storici, Via Benedetto Croce, 12 - 80134

Malerba, Donato

147

Children's School January 2012 Family Spotlight: Rooted in "Da Burgh"  

E-print Network

parents say, Pittsburgh is a great place to raise a family. It has so many great resources for childrenChildren's School January 2012 Family Spotlight: Rooted in "Da Burgh" Bob Slammon and Amy Williams, and we have met so many wonderful people since we moved here. As we've heard many other Children's School

148

carleton universityottaWa, canaDa international  

E-print Network

carleton universityottaWa, canaDa international aDmissions 2014 #12;Carleton University provides high-quality education to students from Canada and around the world. We offer a wide range of programs and be a part of this extraordinary university! Wonderful country The United Nations consistently ranks Canada

Dawson, Jeff W.

149

Ministrio da Educao -MEC Universidade Federal do Paran -UFPR  

E-print Network

LUTZ 3 CARLA APARECIDA RODRIGUES 4 CEZAR DA SILVA 5 CLAUDIA DE BORBA 6 CLAUDIO ANTONIO GHELLERE 7 ELIZABETH PASQUALETTO 11 ELIS CLAUDIA ALMEIDA DE JESUS PADILHA 12 EDIVAL CESAR PAEZE 13 GRACIELE IRMÃ? PIONER ANA MARIA ZANDROVSKI HONÃ?RIO 3 ANGELITA DO ROCIO AMORIM 4 ANTONIO THIESEN JUNIOR 5 ARLINDO COSTA 6

Paraná, Universidade Federal do

150

40 CFR 60.51Da - Reporting requirements.  

Code of Federal Regulations, 2012 CFR

...Performance for Electric Utility Steam Generating Units § 60.51Da Reporting...emissions, the performance test data from the initial and subsequent...for which pollutant or diluent data have not been obtained by...for not obtaining sufficient data; and description of...

2012-07-01

151

40 CFR 60.51Da - Reporting requirements.  

Code of Federal Regulations, 2013 CFR

...Performance for Electric Utility Steam Generating Units § 60.51Da Reporting...emissions, the performance test data from the initial and subsequent...for which pollutant or diluent data have not been obtained by...for not obtaining sufficient data; and description of...

2013-07-01

152

40 CFR 60.51Da - Reporting requirements.  

Code of Federal Regulations, 2014 CFR

...Performance for Electric Utility Steam Generating Units § 60.51Da Reporting...emissions, the performance test data from the initial and subsequent...for which pollutant or diluent data have not been obtained by...for not obtaining sufficient data; and description of...

2014-07-01

153

DATA ASSESSMENT REPORTS FOR CEMS AT SUBPART DA FACILITIES  

EPA Science Inventory

EPA promulgated minimum quality assurance (QA) requirements for Continuous Emission Monitoring Systems (CEMS) in 40 CFR Part 60 Appendix F. Appendix F requires Da source owners to develop site-specific QA plans and report the results of EPA specified QA activities each calendar q...

154

XXIV Congresso Brasileiro de Biblioteconomia, Documentao e Cincia da Informao  

E-print Network

visual, ou de baixa visão, facilitando o acesso a livros didáticos, paradidáticos, infanto literatura infanto-juvenil produzidos pelos alunos da oficina e 400 áudio livros. Atualmente conta com uma

Paraná, Universidade Federal do

155

BENJAMIN FRANKLIN E A HISTÓRIA DA ELETRICIDADE EM LIVROS DIDÁTICOS  

Microsoft Academic Search

Introdução Nos últimos anos, a história da ciência vem sendo introduzida em materiais didáticos utilizados em sala de aula. Uma das razões para isso é a pressão de órgãos governamentais, tais como a Secretaria de Educação Básica, responsável pela avaliação destes livros dentro do Programa Nacional de Livros Didáticos para o ens ino fundamental e médio. Os editais destes programas

Cibelle Celestino Silva; Ana Carolina Pimentel

156

Leonardo da Vinci's Struggles with Representations of Reality  

Microsoft Academic Search

Virtual reality systems seek to simulate real scenes so that they will be seen as three-dimensional. The issues at the heart of virtual reality are old ones. Leonardo da Vinci struggled with the differences between the perception of a scene and a painting of it, which he reduced to the differences between binocular and monocular vision. He could not produce

Nicholas J. Wade; Hiroshi Ono; Linda Lillakas

2001-01-01

157

Sine ars scientia nihil est: Leonardo da Vinci and beyond  

Microsoft Academic Search

The aim of this article is to reflect on the relationship between art and science so far as it concerns a symposium on neurosciences. We undertake a historical overview of that relationship, paying particular attention to the sui generis case of Leonardo da Vinci, who very often is regarded as the man who worked on art and science with equal

Eduardo H. P. Kickhöfel

2009-01-01

158

A Film on Leonardo da Vinci by Luciano Emmer  

Microsoft Academic Search

Leonardo da Vinci probably did not consider the possibility of realizing images with real movement. Many centuries later, however, the author's father, Luciano Emmer, had the idea of reinterpreting the images of the famous artist and scientist using the technique of cinema.

Michele Emmer

2009-01-01

159

O pleno emprego na perspectiva da modernização reflexiva  

Microsoft Academic Search

Resumo O pleno emprego foi o esteio para a segurança social na Primeira Modernidade. As políticas keynesianas implementadas a partir da crise de 1929 caminharam em direção à composição de um Estado- nacional social. O próprio sucesso do capitalismo industrial provoca mudanças. O desenvolvimento tecnológico, a crescente riqueza e a queda do muro de Berlim impulsionam a sociedade industrial para

Maria do Carmo; Cataldi Muterle

160

Governo apresenta reforma da rede do Superior em Maro sem contributo dos reitores  

E-print Network

Governo apresenta reforma da rede do Superior em Março sem contributo dos reitores O Ministério da a racionalização da rede do Superior que vai passar pela cria- ção de consórcios entre universida- des e

Instituto de Sistemas e Robotica

161

Listaxe provisoria de persoas admitidas da convocatoria '[Cod. 652] Bolsas de colaboracin en tarefas bibliogrficas  

E-print Network

1. 2. 3. 4. 5. 6. 7. Listaxe provisoria de persoas admitidas da convocatoria '[Cod. 652] Bolsas de presentación de solicitudes para a selección de bolseiros da convocatoria '[Cod. 652] Bolsas de colaboración en provisoria de persoas admitidas da convocatoria '[Cod. 613] Bolsas de colaboración en tarefas bibliográficas

Fraguela, Basilio B.

162

Listaxe definitiva de persoas admitidas da convocatoria '[Cod. 652] Bolsas de colaboracin en tarefas bibliogrficas  

E-print Network

1. 2. 3. 4. 5. 6. 7. Listaxe definitiva de persoas admitidas da convocatoria '[Cod. 652] Bolsas de presentación de emendas e reclamacións para a selección de bolseiros da convocatoria '[Cod. 652] Bolsas de admitidas da convocatoria '[Cod. 613] Bolsas de colaboración en tarefas bibliográficas - Facultade de

Fraguela, Basilio B.

163

PREVISÃO DA VAZÃO AFLUENTE MENSAL DO RIO SÃO FRANCISCO USANDO-SE REDES DE ELMAN  

Microsoft Academic Search

Resumo: Este artigo apresenta resultados de previsão da vazão afluente mensal do Rio São Francisco, que alimenta a usina de Sobradinho, usando-se redes neurais de Elman (RNA). As redes neurais de Elman utilizadas foram preparadas com o objetivo de receber como entrada amostras da série temporal da vazão afluente do Rio São Francisco deslocadas mês a mês. Para tal, nas

Luiz Biondi Neto; Pedro Henrique Gouvêa Coelho; Luís Chiganer; Lídia Angulo Meza; Luiz Palmeira Monteiro

2005-01-01

164

First experiences with the da Vinci™ operating robot in thoracic surgery  

Microsoft Academic Search

Objectives: The da Vinci™ surgical robotic system was purchased at our institution in June 2001. The aim of this trial was to evaluate the applicability of the da Vinci™ operation robot for general thoracic procedures. Methods: The da Vinci™ surgical system consists of a console connected to a surgical arm cart, a manipulator unit with two instrument arms and a

J. Bodner; H. Wykypiel; G. Wetscher; T. Schmid

2004-01-01

165

Roles and Delegation of Authority (R/DA) System  

SciTech Connect

The processes of defining managerial roles and providing for delegation of authority are essential to any enterprise. At most large organizations, these processes are defined in policy manuals and through sets of standard operating procedures for many, if not all, business and administrative functions. Many of these staff-initiated, administrative functions require the routing of documents for approval to one or more levels of management. These employee-oriented, back office types of workflows tend to require more flexibility in determining to whom these documents should go to, while, at the same time, providing the responsible parties with the flexibility to delegate their approval authority or allow others to review their work. Although this practice is commonplace in manual, paper-based processes that exist in many organizations, it is difficult to provide the same flexibility in the more structured, electronic-based, workflow systems. The purpose of this report is to present a framework or architecture for creating a R/DA system and provide some insights associated with its design and utilization. To improve understanding and clarify subsequent discussion, the goals and requirements for the major R/DA system components, namely, the database and interface modules, are initially presented along with the identification of important concepts and the definition of critical terms. Next high-level functions relating the types of inputs to the outputs of the R/DA interface module are introduced and discussed. Then the relationships between the major R/DA modules and the primary components associated with its creation and maintenance are presented and analyzed. Finally, some conclusions are drawn relative to the advantages associated with developing a R/DA system for use in implementing an enterprise-wide, work-facilitating information system.

ABBOTT,JOHN P.; HUTCHINS,JAMES C.; SCHOCH,DAVID G.

1999-11-01

166

SECRETARIA DE ASSISTNCIA ESTUDANTIL Rua Paulo Gama n. 110, Prdio 12105, Ex. Prdio da Filosofia, Anexo 1 da Reitoria  

E-print Network

alunos participantes: 2.2 - Dados pessoais e Bancários Nº Cartão UFRGS: Nome Completo Requerente 1: CPF: _________________________ Nº Cartão UFRGS: Nome Completo Requerente 2: CPF: RG. Fone Res: Celular: E-mail: Dados Bancários Nº e: _________________________________________ Nº da Conta Corrente: _________________________ Nº Cartão UFRGS: Nome Completo Requerente 3: CPF: RG

Mendes, Luis Gustavo Doninelli

167

PRODUÇÃO E CARACTERIZAÇÃO DE CARVÃO ATIVADO OBTIDO A PARTIR DA BORRACHA DE PNEU E AVALIAÇÃO DA EFICIÊNCIA DE REMOÇÃO DE SAXITOXINAS.  

E-print Network

??As cianobactérias constituem o maior e mais diverso grupo de micro-organismos procarióticos, sendo um dos componentes naturais da comunidade fitoplanctônica de qualquer ecossistema aquático, entretanto,… (more)

Rodrigo Matias de Sousa Resende

2011-01-01

168

Prevalência da presença de anticorpos da classe IgG Anti-toxocara sp em gestantes atendidas no Hospital Universitário de Brasília.  

E-print Network

??Dissertação (mestrado)—Universidade de Brasília, Faculdade de Ciências da Saúde, 2007. A Toxocaríase é uma antropozoonose cosmopolita de distribuição mundial, que acomete indivíduos de todas as… (more)

Pereira, Lívia Custódio

2007-01-01

169

Some radical queries.  

PubMed

A little over 500 years ago, Vasco da Gama arrived on the west coast of India after the first direct sea voyage from Portugal with the intention of developing trade in spices, particularly in black pepper. Portugese took the merchandise, and much more; they ended up colonizing Goa. In 1999 delegates from all over the world came to this fabulous Goa for a symposium on antioxidants, some of which are natural products found in spices. Some views and queries on the interaction of antioxidants and radicals are presented. PMID:10962126

Ramasarma, T

2000-08-01

170

DA-9801 Promotes Neurite Outgrowth via ERK1/2-CREB Pathway in PC12 Cells.  

PubMed

In the present study, we examined the mechanisms underlying the effect of DA-9801 on neurite outgrowth. We found that DA-9801 elicits its effects via the mitogen-activated protein kinase (MEK) extracellular signal-regulated kinase (ERK)1/2-cAMP response element-binding protein (CREB) pathway. DA-9801, an extract from a mixture of Dioscorea japonica and Dioscorea nipponica, was reported to promote neurite outgrowth in PC12 cells. The effects of DA-9801 on cell viability and expression of neuronal markers were evaluated in PC12 cells. To investigate DA-9801 action, specific inhibitors targeting the ERK signaling cascade were used. No cytotoxicity was observed in PC12 cells at DA-9801 concentrations of less than 30 ?g/mL. In the presence of nerve growth factor (NGF, 2 ng/mL), DA-9801 promoted neurite outgrowth and increased the relative mRNA levels of neurofilament-L (NF-L), a marker of neuronal differentiation. The Raf-1 inhibitor GW5074 and MEK inhibitor PD98059 significantly attenuated DA-9801-induced neurite outgrowth. Additionally, the MEK1 and MEK2 inhibitor SL327 significantly attenuated the increase in the percentage of neurite-bearing PC12 cells induced by DA-9801 treatment. Conversely, the selective p38 mitogen-activated protein kinase inhibitor SB203580 did not attenuate the DA-9801 treatment-induced increase in the percentage of neurite-bearing PC12 cells. DA-9801 enhanced the phosphorylation of ERK1/2 and CREB in PC12 cells incubated with and without NGF. Pretreatment with PD98059 blocked the DA-9801-induced phosphorylation of ERK1/2 and CREB. In conclusion, DA-9801 induces neurite outgrowth by affecting the ERK1/2-CREB signaling pathway. Insights into the mechanism underlying this effect of DA-9801 may suggest novel potential strategies for the treatment of peripheral neuropathy. PMID:25482167

Won, Jong Hoon; Ahn, Kyong Hoon; Back, Moon Jung; Ha, Hae Chan; Jang, Ji Min; Kim, Ha Hyung; Choi, Sang-Zin; Son, Miwon; Kim, Dae Kyong

2014-12-01

171

TA-DA: A TOOL FOR ASTROPHYSICAL DATA ANALYSIS  

SciTech Connect

We present the Tool for Astrophysical Data Analysis (TA-DA), a new software aimed to greatly simplify and improve the analysis of stellar photometric data in comparison with theoretical models, and allow the derivation of stellar parameters from multi-band photometry. Its flexibility allows one to address a number of such problems: from the interpolation of stellar models, or sets of stellar physical parameters in general, to the computation of synthetic photometry in arbitrary filters or units; from the analysis of observed color-magnitude diagrams to a Bayesian derivation of stellar parameters (and extinction) based on multi-band data. TA-DA is available as a pre-compiled Interactive Data Language widget-based application; its graphical user interface makes it considerably user-friendly. In this paper, we describe the software and its functionalities.

Da Rio, Nicola [European Space Agency, Keplerlaan 1, 2200-AG Noordwijk (Netherlands); Robberto, Massimo, E-mail: ndario@rssd.esa.int [Space Telescope Science Institute, 3700 San Martin Dr., Baltimore, MD 21218 (United States)

2012-12-01

172

Identification of an abundant 56 kDa protein implicated in food allergy as granule-bound starch synthase  

Technology Transfer Automated Retrieval System (TEKTRAN)

Rice, the staple food of South and East Asian counties, is considered to be hypoallergenic. However, several clinical studies have documented rice-induced allergy in sensitive patients. Rice proteins with molecular weights of 14-16 kDa, 26 kDa, 33 kDa and 56 kDa have been identified as allergens. Re...

173

Da universidade para o mercado de trabalho em onze pases  

E-print Network

Universia está a ser lançado em várias instituições de ensino superior portuguesas. Rede ibero-americana regista por mês 195 mil ofertas ANA BELA FERREIRA Desde quinta-feira que os 23 mil alunos da Universidade a pró-rei- tora, Ana Nunes de Almeida. Ao aderir a esta plataforma, que con- centra não só ofertas

Instituto de Sistemas e Robotica

174

Recent results from KLOE at DA?NE  

Microsoft Academic Search

The KLOE experiment at the DA?NE e+e? collider and its physics program is presented. The most recent results obtained using the data collected during the year 2000 (about 20 pb?1) are presented, in particular the ratio of branching ratios BR(KS ? ?+??)\\/BR(Ks ? ?0?0), the branching ratio for the Ke3 decay of the KS, the ratio BR(? ? ???)\\/BR(? ?

A. Aloisio; F. Ambrosino; A. Antonelli; M. Antonelli; C. Bacci; G. Bencivenni; S. Bertolucci; C. Bini; C. Bloise; V. Bocci; F. Bossi; P. Branchini; S. A. Bulychjov; R. Caloi; P. Campana; G. Capon; G. Carboni; M. Casarsa; V. Casavola; G. Cataldi; F. Ceradini; F. Cervelli; F. Cevenini; G. Chiefari; P. Ciambrone; S. Conetti; E. De Lucia; G. De Robertis; P. De Simone; G. De Zorzi; S. Dell'Agnello; A. Denig; A. di Domenico; C. di Donato; S. Di Falco; A. Doria; M. Dreucci; O. Erriquez; A. Farilla; G. Felici; A. Ferrari; M. L. Ferrer; G. Finocchiaro; C. Forti; A. Franceschi; P. Franzini; C. Gatti; P. Gauzzi; S. Giovannella; E. Gorini; F. Grancagnolo; E. Graziani; S. W. Han; M. Incagli; M. Ingrosso; W. Kluge; C. Kuo; V. Kulikov; F. Lacava; G. Lanfranchi; J. Lee-Franzini; D. Leone; F. Lu; M. Martemianov; M. Matsyuk; W. Mei; L. Merola; R. Messi; S. Miscetti; M. Moulson; S. Müller; F. Murtas; M. Napolitano; A. Nedosekin; F. Nguyen; M. Palutan; L. Paoluzi; E. Pasqualucci; L. Passalacqua; A. Passeri; V. Patera; E. Petrolo; L. Pontecorvo; M. Primavera; F. Ruggieri; P. Santangelo; E. Santovetti; G. Saracino; R. D. Schamberger; B. Sciascia; A. Sciubba; F. Scuri; I. Sfiligoi; T. Spadaro; E. Spiriti; G. L. Tong; L. Tortora; E. Valente; P. Valente; B. Valeriani; G. Venanzoni; S. Veneziano; A. Ventura; G. Xu; G. W. Yu

2002-01-01

175

?, ?' Studies with the KLOE Detector at DA?NE  

Microsoft Academic Search

The KLOE detector is operational since spring '99 at DA?NE, the Frascati e+e- collider, a ?-factory running at 1.02 GeV c.m. energy. This detector has been designed and built with the primary goal of measuring Re(?' \\/ ?), the CP violation parameter in the kaon system, with a sensitivity of about one part in ten thousands. Apart from CP studies

A Farilla; A Aloisio; F Ambrosino; A Antonelli; M Antonelli; C Bacci; G Bencivenni; S Bertolucci; C Bini; C Bloise; V Bocci; F Bossi; P Branchini; S A Bulychjov; R Caloi; P Campana; G Capon; G Carboni; M Casarsa; V Casavola; G Cataldi; F Ceradini; F Cervelli; F Cevenini; G Chiefari; P Ciambrone; S Conetti; E De Lucia; G De Robertis; P De Simone; G De Zorzi; S Dell'Agnello; A Denig; A Di Domenico; C Di Donato; S Di Falco; A Doria; M Dreucci; O Erriquez; G Felici; A Ferrari; M L Ferrer; G Finocchiaro; C Forti; A Franceschi; P Franzini; C Gatti; P Gauzzi; S Giovannella; E Gorini; F Grancagnolo; E Graziani; S W Han; M Incagli; L Ingrosso; W Kluge; C Kuo; V Kulikov; F Lacava; G Lanfranchi; J Lee-Franzini; D Leone; F Lu; M Martemianov; M Matsyuk; W Mei; L Merola; R Messi; S Miscetti; M Moulson; S Müller; F Murtas; M Napolitano; A Nedosekin; F Nguyen; M Palutan; L Paoluzi; E Pasqualucci; L Passalacqua; A Passeri; V Patera; E Petrolo; L Pontecorvo; M Primavera; F Ruggieri; P Santangelo; E Santovetti; G Saracino; R D Schamberger; B Sciascia; A Sciubba; F Scuri; I Sfiligoi; T Spadaro; E Spiriti; G L Tong; L Tortora; E Valente; P Valente; B Valeriani; G Venanzoni; S Veneziano; A Ventura; G Xu; G W Yu

2002-01-01

176

TUTORIAL DE PESQUISA BIBLIOGRTUTORIAL DE PESQUISA BIBLIOGRTUTORIAL DE PESQUISA BIBLIOGRTUTORIAL DE PESQUISA BIBLIOGRFICAFICAFICAFICA Este tutorial faz parte da programao de treinamentos da Biblioteca de Cincias daBiblioteca de Cincias daBiblioteca de Cinc  

E-print Network

SaSaSaúúúúdededede ­­­­ SdSdSdSd da Universidade Federal do Paranda Universidade Federal do Paranda Universidade Federal do Paranda Universidade Federal do Paranáááá.... Serve como material de apoio e não possui fins lucrativos 11111111 3.1 Online Search3.1 Online Search3.1 Online Search3.1 Online Search ---- Pesquisa Online

Paraná, Universidade Federal do

177

The DA+dMe Binary WD 0334-6400  

Microsoft Academic Search

Multiwavelength observations of the star WD 0334-6400 (or Ret 1 in A Catalog and Altas of Cataclysmic Variables: Living Edition) show it to be a DA+dMe binary. Our analysis of the far-ultraviolet continuum and spectral lines reveal that Teff = 36500 K; log g = 7.7; and the photosphere contains C, N, O, Si, P, and S. C\\/H = 2

P. E. Barrett; E. M. Schlegel; J. Dupuis; B. Heathcote

2005-01-01

178

Ministrio da Educao e do Desporto UNIVERSIDADE FEDERAL DO PARAN  

E-print Network

-Graduação Setor de Tecnologia PROGRAMA DE P�S-GRADUA��O EM ENGENHARIA DE ALIMENTOS Programa de Pós-Graduação em ENGENHARIA DE ALIMENTOS (PPGEALTC/UFPR) UFPR / TC - Setor de Tecnologia - Centro Politécnico - Jardim das Alimentos do Setor de Tecnologia da Universidade Federal do Paraná, no uso de suas atribuições, para que se

Paraná, Universidade Federal do

179

Ministrio da Educao e do Desporto UNIVERSIDADE FEDERAL DO PARAN  

E-print Network

-Graduação Setor de Tecnologia PROGRAMA DE P�S-GRADUA��O EM ENGENHARIA DE ALIMENTOS Programa de Pós-Graduação em Engenharia de Alimentos UFPR / TC - Setor de Tecnologia - Centro Politécnico - Jardim das Américas Caixa de Alimentos do Setor de Tecnologia da Universidade Federal do Paraná, no uso de suas atribuições e

Paraná, Universidade Federal do

180

UNIVERSIDADE FEDERAL DE SANTA CATARINA CENTRO DE CINCIAS DA EDUCAO  

E-print Network

.ppge.ufsc.br a partir de 13 de março de 2012); - Cópia da Carteira de Identidade e do CPF; - Cópia do DIPLOMA e do Pesquisa, anônimo (apenas o CPF identificará o candidato), contendo `folha de rosto' (disponível a partir (Instituto Cultural Brasil/Estados Unidos), IELTS ou PET (C

Floeter, Sergio Ricardo

181

Ris-R-1196(DA) Forskning i Aeroelasticitet -EFP-99  

E-print Network

Risø-R-1196(DA) Forskning i Aeroelasticitet - EFP-99 Redigeret af Helge Aagaard Madsen vingeprofil. Som en fortsættelse af aktiviteterne under EFP-97 og EFP-98 med afklaring af årsager- ne til dobbelt-stall og udarbejdelse af løsningsforslag til afhjælpning af dette fænomen er der under EFP-99

182

PODER JUDICIRIO TRIBUNAL DE JUSTIA DO ESTADO DA BAHIA  

E-print Network

Justiça, torna pública a convocação da candidata sub judice Mariana Ferreira Spina, inscrição nº 10007049 inscrição e nome do candidato em ordem alfabética. INSCRI��O NOME DO CANDIDATO 10007049 Mariana Ferreira Bahia e divulgado na internet, no endereço eletrônico http://www.cespe.unb.br/concursos/tj_bajuiz2012

Maier, Rudolf Richard

183

Tarântula - Sistema de Recolha de Documentos da Web  

Microsoft Academic Search

A recolha de colec??es de documentos é uma tarefa cada vez mais comum nos sistemas que actuam sobre a WWW. Este artigo apresenta um novo sistema de recolha de documentos da Web, com características de configura??o, integra??o e distribui??o que permitem a sua fácil adapta??o e integra??o em aplica??es de diferentes naturezas. Descrevemos a sua arquitectura, funcionamento e os resultados

Daniel Gomes; Mário J. Silva

2001-01-01

184

Improving Security in the ATLAS PanDA System  

NASA Astrophysics Data System (ADS)

The security challenges faced by users of the grid are considerably different to those faced in previous environments. The adoption of pilot jobs systems by LHC experiments has mitigated many of the problems associated with the inhomogeneities found on the grid and has greatly improved job reliability; however, pilot jobs systems themselves must then address many security issues, including the execution of multiple users' code under a common 'grid' identity. In this paper we describe the improvements and evolution of the security model in the ATLAS PanDA (Production and Distributed Analysis) system. We describe the security in the PanDA server which is in place to ensure that only authorized members of the VO are allowed to submit work into the system and that jobs are properly audited and monitored. We discuss the security in place between the pilot code itself and the PanDA server, ensuring that only properly authenticated workload is delivered to the pilot for execution. When the code to be executed is from a 'normal' ATLAS user, as opposed to the production system or other privileged actor, then the pilot may use an EGEE developed identity switching tool called gLExec. This changes the grid proxy available to the job and also switches the UNIX user identity to protect the privileges of the pilot code proxy. We describe the problems in using this system and how they are overcome. Finally, we discuss security drills which have been run using PanDA and show how these improved our operational security procedures.

Caballero, J.; Maeno, T.; Nilsson, P.; Stewart, G.; Potekhin, M.; Wenaus, T.

2011-12-01

185

Infraestrut. Financiamiento publico procedente da Unin Europea X X  

E-print Network

I+D+i Docencia Relac.Soc. Xestión Infraestrut. Financiamiento publico procedente da Unión Europea X X Aposta dos poderes públicos polo investimento en I+D+i X X Estabilidade do financiamento público autonómico para o período 2005-10 X X X X Demanda tecnolóxica por parte do sector empresarial próximo X X X X

Fraguela, Basilio B.

186

Livro Autor (es) Quantidade Currculos de Matemtica: da  

E-print Network

Livro Autor (es) Quantidade Currículos de Matemática: da organização linear à ideia de rede Célia Judith Haymore Sandholtz 1 exemplar Umberto Eco ; Jean-Claude Carrière Não contem com o fim do livro 1 respectivamente Livro acessível e informática acessível Acompanha CD Amanda M. Melo 3 exemplares respectivamente

Floeter, Sergio Ricardo

187

Stroemgren photometry of ZZ Ceti and other DA white dwarfs  

SciTech Connect

Stroemgren colors for a sample of 71 stars classified as DA white dwarfs are presented. Comparison with the recent model atmospheres of the Kiel group indicates that the average gravity of 63 stars of the sample is log g = 7.98 +- 0.31, with no indication of a dependence on the effective temperature. This is consistent with the theoretical expectation that white dwarfs evolve at constant gravity. Correlations between Stroemgren colors and Greenstein multichannel colors are also given, using 52 stars that have been observed in common in the two systems. These correlations are used to compare the data with a second set of model atmospheres computed by Shipman. Contrary to what has been suggested in the past, no fundamental differences are found when confronting the Stroemgren data with the DA model atmospheres of Shipman or those of the Kiel group. Finally, observations of 11 pulsating objects reveal the existence of a narrow instability strip in the range 13 000 K> or approx. =T/sub e/> or approx. =11 000 K in a ((u-b), (b-y)) two-color diagram. The present results add evidence to the contention that all DA white dwarfs evolve to become ZZ Ceti pulsators in the instability strip.

Fontaine, G.; Bergeron, P.; Lacombe, P.; Lamontagne, R.; Talon, A.

1985-06-01

188

Two different molecular species of pig calpastatin. Structural and functional relationship between 107 kDa and 68 kDa molecules.  

PubMed Central

Calpastatin, the inhibitor protein acting specifically on calpain (EC 3.4.22.17; Ca2+-dependent cysteine proteinase), is known to be widely distributed in mammalian and avian cells. Two different molecular species of calpastatin were isolated and purified to homogeneity from pig heart muscle and from pig erythrocytes, and shown to be of 107 kDa and 68 kDa respectively on SDS/polyacrylamide-gel electrophoresis. Both calpastatins had very similar amino acid compositions when expressed as mol per cent of the residues, differed by only 0.1 pH unit in their isoelectric points, and showed immunological cross-reactivity. One molecule of the 107 kDa species could bind approx. 8 calpain molecules, whereas the 68 kDa inhibitor could bind approx. 5 calpain molecules. These findings suggest similar protein structures of the 107 kDa and 68 kDa calpastatins, each being composed of extended multidomains, with unit inhibitor domains aligned along the polypeptide chain of the molecule. The present study does not conclude, however, whether or not the 68 kDa calpastatin found in erythrocytes is a derived product from the 107 kDa species, which is present as such in heart muscle. Images Fig. 1. Fig. 4. PMID:3755595

Takano, E; Kitahara, A; Sasaki, T; Kannagi, R; Murachi, T

1986-01-01

189

Rotaxane Metal Organic Nanocomposites MW = 6.80kDa, V = >10nm3MW = 6.80kDa, V = >10nm3  

E-print Network

Rotaxane Metal Organic Nanocomposites MW = 6.80kDa, V = >10nm3MW = 6.80kDa, V = >10nm3 Zaworotko for metal organic catenanes and rotaxanes in drug delivery, bactericide containing biomedical devices the matrix and metal organic moieties. For initial studies (27, 28) we chose the following metal organic

Harmon, Julie P.

190

Métodos de coleta de fezes e determinação dos coeficientes de digestibilidade da fração protéica e da energia de alimentos para o pacu, Piaractus mesopotamicus (Holmberg, 1887)  

Microsoft Academic Search

RESUMO - Para melhorar a alimentação do pacu (Piaracatus mesopotamicus), é necessário conhecer o nível de aproveitamento dos ingredientes utilizados em suas dietas. Neste trabalho, inicialmente, foram analisados quatro métodos de coleta de fezes, em função da precisão e da versatilidade (dissecação, extrusão, Guelph e Guelph modificado), e o tempo entre as coletas de fezes nos sistemas de Guelph, por

Eduardo Gianini Abimorad; Dalton José Carneiro

2004-01-01

191

A INFLUÊNCIA DA FEBRE AFTOSA NO PREÇO DE MERCADO DA ARROBA DO BOI GORDO RECEBIDO PELO PRODUTOR NO BRASIL  

Microsoft Academic Search

O presente estudo tem como objetivo identificar alguns fatos que influenciaram os preços da arroba do boi gordo recebido pelo produtor bem como realizar estimativas desses preços para um período de quatro meses a partir de maio de 2007. Para tanto, utilizou-se a metodologia idealizada por Box-Jenkins (1976). Os resultados demonstraram que a série em questão (01\\/1996-05\\/2007) apresenta uma quebra

Gibran da Silva Teixeira; Sinezio Fernandes Maia

2008-01-01

192

Larch arabinogalactan for hepatic drug delivery: isolation and characterization of a 9 kDa arabinogalactan fragment.  

PubMed

Purified arabinogalactan [AG(37 kDa)] from Larix occidentalis is composed of repeating units of similar molecular weight and composition. A 9 kDa arabinogalactan [AG(9 kDa)] has been obtained in high yield from AG(37 kDa) either by autoclaving at 121 degrees C or by exposure to alkaline solution in the presence of sodium borohydride. The weight average molecular weight of AG(37 (kDa) was determined to be 37 and 38 kDa by intensity light scattering and sedimentation equilibrium, respectively. The weight average molecular weight of AG(9 kDa) was determined to be 9.1 and 9.5 kDa by intensity light scattering and sedimentation equilibrium, respectively. MALDI-TOF mass spectrometry yielded a molecular weight at the peak of the distribution of 8.3 kDa for AG(9 kDa). Both AG(37 kDa) and AG(9 kDa) exhibited narrow molecular-weight distributions (Mw/Mn approximately 1.2). AG(37 kDa) and AG(9 kDa) exhibit nearly identical 13C-NMR spectra, monosaccharide composition, and sugar linkages. It is proposed that AG(37 kDa) is composed of covalently bound subunits of AG(9 kDa). AG(37 kDa) and AG(9 kDa) bind isolated hepatocyte asialoglycoprotein receptor equally well. As a result AG(9 kDa) is a candidate for use in hepatocyte directed drug delivery and may be more desirable for such use than is AG(37 kDa). PMID:8536264

Prescott, J H; Enriquez, P; Jung, C; Menz, E; Groman, E V

1995-11-30

193

Characterization of partially purified 8 kDa antigenic protein of Clonorchis sinensis  

Microsoft Academic Search

The 8 kDa antigenic protein of Clonorchis sinensis was partially purified by ammonium sulfate precipitation and subsequently by a column chromatographic steps. The purified protein was separated into 7 and 8 kDa protein bands through SDS-tricine gel electrophoresis, while the protein was found to migrate to a 8 kDa band in 7.5-15% SDS-PAGE. The molecular weight of the antigen was

Young-Bae Chung; Mejeong Lee; Hyun-Jong Yang; Byung-Suk Chung; Shun-Yu Lee; Min-Ho Choi; Sung-Tae Hong

2002-01-01

194

On-demand TCP: transparent peer to peer TCP\\/IP over IrDA  

Microsoft Academic Search

This paper describes a novel approach to using TCP\\/IP applications over IrDA (Infrared Data Association) and Bluetooth. First, we look into why so few applications are available over IrDA and what is necessary to make the use of those applications attractive to end-users. Then, we present a new scheme that enables the use of the IrDA communication layer by those

Jean Tourrilhes; Luiz Magalhaes; Casey Carter

2002-01-01

195

Facultade de Ciencias da Educacin Mster Universitario en Psicopedagoga por la Universidad de A Corua  

E-print Network

Facultade de Ciencias da Educación Máster Universitario en Psicopedagogía por la Universidad de Verificación Facultad de Ciencias de la Educación Universidad de A Coruña Año 2013 #12;Facultade de Ciencias da Ciencias da Educación Máster Universitario en Psicopedagogía por la Universidad de A Coruña Página 3 de 134

Fraguela, Basilio B.

196

Molecular cloning and characterization of 58 kDa chitinase gene from Serratia marcescens KCTC 2172  

Microsoft Academic Search

A chitinase gene (pCHi58) encoding a 58 kDa chitinase was isolated from theSerratia marcescens KCTC 2172 cosmid library. The chitinase gene consisted of a 1686 bp open reading frame that encoded 562 amino acids.Escherichia coil harboring the pChi58 gene secreted a 58 kDa chitinase into the culture supernatant. The 58 kDa chitinase was purified using\\u000a a chitin affinity column and

Sang Wan Gal; S. W. Lee; Y. J. Choi

2002-01-01

197

A teoria da percolação aplicada às galáxias aneladas peculiares  

NASA Astrophysics Data System (ADS)

Formulado no final da década de 50, o modelo de percolação concentra-se em descrever o meio poroso, que será visto neste trabalho como uma rede de canais aleatórios, por onde escoa um fluido determinístico. Se o número de canais for suficientemente grande, então eles estarão ligados e o meio se tornará permeável à passagem do fluido. Neste caso, dizemos que houve a percolação do fluido. Reformulando o modelo acima, podemos escrever um código particularmente adaptado para simulações em Galáxias, onde iremos supor que os canais formam um reticulado, e que cada sítio da rede representa um poro que será interpretado como uma região ativa de formação estelar. Para cada elo teremos um pequeno canal ligando dois sítios vizinhos, que poderá, após um tempo "t", induzir ou não a formação de uma região ativa no poro vizinho. Para simular a passagem desta região ativa através dos poros, diremos que um elo está aberto com probabilidade p e fechado com probabilidade 1-p. Dessa forma, passamos a imaginar configurações de elos abertos e fechados, onde cada configuração ocorre com uma certa probabilidade, dada por p|A|(1-p)|F|, onde |A| é o número de elos abertos e |F| o número de elos fechados da configuração. A expressão anterior só tem importância física se |A| e |F| forem ambos finitos, pois, caso contrário, a probabilidade de ocorrência de uma dada configuração será sempre nula. Neste trabalho, foram considerados dados cinemáticos publicados na literatura bem como aqueles obtidos pelos autores a partir de observações fotométricas realizadas no Observatório de Las Campanãs, em 1994, para a Galáxia Anelada Peculiar HRG 03401. Mostraremos que para certos valores de p, situados entre 0,5 e 0,6, os clusters assim formados irão simular, de maneira coerente, o referido objeto.

Poppe, P. C. R.; Martin, V. A. F.; de Medeiros, N. G. F.; Faúndez-Abans, M.; Oliveira-Abans, M.

2003-08-01

198

18 kDa translocator protein - implications in cell's functions.  

PubMed

The mitochondrial 18kDa Translocation Protein (TSPO) was first identified in 1977 by its capability to bind benzodiazepines in peripheral tissues. It is more commonly known after its previous name - peripheral benzodiazepine receptor (PBR) as opposed to the central benzodiazepine receptor (CBR), from which it differs by location, structure and function. It is ubiquitous with highest expression in steroid-producing tissues, like adrenal cortex, ovaries, testicles, and placenta. The role of TSPO is crucial for living; its inactivation results in early embryonic-lethal phenotype in mice. TSPO has been implicated in various functions of cell, including steroidogenesis, cellular respiration, reactive oxygen species production, heme biosynthesis, immunomodulation, apoptosis, and cellular proliferation. TSPO has been shown to interact with other cellular proteins: 32 kDa voltage-dependent anion channel (VDAC), 30 kDa adenine nucleotide translocase (ANT), cyclophilin D, hexokinase, creatinine kinase, diazepam binding inhibitor (DBI), phosphate carrier and Bcl-2 family. They are - involved in the formation and regulation of mitochondrial permeability transition pore (mPTP) at the junction of the inner and outer mitochondrial membranes. While the function and characteristics of the mPTP are known, its well defined, but its structure remains speculative. Changes in TSPO expression are associated with multiple disorders, including cancer, ischaemia-reperfusion injury, neurological diseases and psychiatric disorders, atheromatosis, and others. - TSPO is able to bind cholesterol, porphyrins and other ligands with different affinity. The current knowledge of TSPO implicates its potential use as a diagnostic marker and therapeutic target in different diseases and their therapies. PMID:25589712

Ko?odziejczyk, Agnieszka

2015-01-01

199

Negligible pharmacokinetic interaction between oral DA-8159, a new erectogenic, and amlodipine in rats.  

PubMed

A pharmacokinetic interaction between oral DA-8159 and amlodipine was evaluated in male Sprague-Dawley rats. In rats pretreated with troleandomycin (a main inhibitor of CYP3A1/2 in rats), the AUC(0-6 h) of amlodipine was significantly greater than the controls (34.5+/-6.01 compared with 28.0+/-4.70 microg min/ml), indicating that amlodipine is metabolized via CYP3A1/2 in rats. It was reported that the metabolism of DA-8159 and the formation of DA-8164 (a metabolite of DA-8159) were mainly mediated via CYP3A1/2 in rats, and amlodipine significantly inhibited the CYP3A2 in rats. Therefore, a pharmacokinetic interaction between the two drugs could be expected. However, after oral administration of DA-8159 at a dose of 30 mg/kg with or without oral amlodipine at a dose of 5 mg/kg to rats, the pharmacokinetic parameters of DA-8159 and DA-8164 were not significantly different between the two groups of rats. Similar results were also obtained from amlodipine between with and without DA-8159. The above data indicated that the pharmacokinetic interaction between oral DA-8159 and amlodipine was almost negligible in rats. PMID:16400709

Lee, Joo H; Kim, Eun J; Kwon, Jong W; Yoo, Moohi; Lee, Myung G

2006-04-01

200

The effect of repeated amphetamine treatment on striatal DA transporter and rotation in rats.  

PubMed

The effect of repeated amphetamine treatment on the involvement of the striatal DA transporters in rotation behavior was tested in rats. Repeated amphetamine treatment had no effect on [3H]DA uptake or [3H]GBR-12935 binding density. However, unlike the naive rats who rotated away from the striatum with a lower density of DA transporters, rats sensitized to amphetamine rotated toward the striatum with a lower density of DA transporters. These findings imply that repeated amphetamine augments the subcortical involvement in behavioral output. PMID:7704609

Mintz, M; Gordon, I; Roz, N; Rehavi, M

1994-12-30

201

Elementos de Teoria da Informac~ao Mario A. T. Figueiredo  

E-print Network

Elementos de Teoria da Informa¸c~ao M´ario A. T. Figueiredo Departamento de Engenharia Electrot #12;2 #12;Conte´udo 1 Introdu¸c~ao `a Teoria da Informa¸c~ao 5 1.1 Fontes de Informa¸c~ao sem Mem A Demonstra¸c~ao do Teorema da M´edia de Ces`aro 65 #12;Cap´itulo 1 Introdu¸c~ao `a Teoria da Informa

Figueiredo, Mário A. T.

202

Avaliação da infecção por morbilivírus em cetáceos arrojados na costa portuguesa.  

E-print Network

??Dissertação de Mestrado Integrado em Medicina Veterinária O Dolphin morbilivírus (DMV) e o Porpoise morbillivirus (PMV) são membros da subfamília Paramyxovirinae, família Paramyxoviridae. Estes vírus… (more)

Bento, Maria Carolina Rocha de Medeiros

2012-01-01

203

Evolution of the ATLAS PanDA workload management system for exascale computational science  

NASA Astrophysics Data System (ADS)

An important foundation underlying the impressive success of data processing and analysis in the ATLAS experiment [1] at the LHC [2] is the Production and Distributed Analysis (PanDA) workload management system [3]. PanDA was designed specifically for ATLAS and proved to be highly successful in meeting all the distributed computing needs of the experiment. However, the core design of PanDA is not experiment specific. The PanDA workload management system is capable of meeting the needs of other data intensive scientific applications. Alpha-Magnetic Spectrometer [4], an astro-particle experiment on the International Space Station, and the Compact Muon Solenoid [5], an LHC experiment, have successfully evaluated PanDA and are pursuing its adoption. In this paper, a description of the new program of work to develop a generic version of PanDA will be given, as well as the progress in extending PanDA's capabilities to support supercomputers and clouds and to leverage intelligent networking. PanDA has demonstrated at a very large scale the value of automated dynamic brokering of diverse workloads across distributed computing resources. The next generation of PanDA will allow other data-intensive sciences and a wider exascale community employing a variety of computing platforms to benefit from ATLAS' experience and proven tools.

Maeno, T.; De, K.; Klimentov, A.; Nilsson, P.; Oleynik, D.; Panitkin, S.; Petrosyan, A.; Schovancova, J.; Vaniachine, A.; Wenaus, T.; Yu, D.; Atlas Collaboration

2014-06-01

204

Da Vinci's codex and the anatomy of healthcare.  

PubMed

We usually display a laid-back approach to medical jargon throughout our theatre work. The word 'perioperative' is built from the Greek word 'peri' (around) and the Latin 'operari' (to work). Latin and Greek became the prefixed language of choice for Leonardo da Vinci, and his research was pivotal in determining the way in which surgical procedures are documented. Ancient manuscripts aided the unfolding of the secrets of anatomy, and Leonardo revealed that art was the key in expressive detailed explanation. PMID:23248927

Stephens-Borg, Keith

2012-08-01

205

UNIVERSIDADE FEDERAL DE SANTA CATARINA CENTRO DE CINCIAS DA EDUCAO  

E-print Network

não homologaçãoNascimentoNome do CandidatoInscrição CPF diferente em 2 inscrições282 12-08-2008GUSTAVO LUIZ DA SILVEIRA Série e CPF diferentes em 2 inscrições505 07-01-2007SABRINA DO CARMO Dt. de nascto LEAL GUARITA Série e CPF diferentes em 2 inscrições298 10-11-2007ARTHUR TAVARES FRUTUOSO Série e CPF

Floeter, Sergio Ricardo

206

Easy CD-DA Extractor 4.5.2  

NSDL National Science Digital Library

Billing itself as "the most complete CD-ripping solution available" as well as the fastest (a 40 percent increase in performance since the last edition), Easy CD-DA Extractor supports a variety of formats: mp3, Windows Media Player, Ogg Vorbis, TwinVQ, .wav, and .aiff. Using the program, you can copy CDs and convert from any of the supported formats (except .aiff) to any other. Users can define the length of the tracks they record; download in formation from the freedb, the Internet Compact Disc Database; normalize the music; and more. The program is shareware and costs $19.95.

2001-01-01

207

Visual tracking of da Vinci instruments for laparoscopic surgery  

NASA Astrophysics Data System (ADS)

Intraoperative tracking of laparoscopic instruments is a prerequisite to realize further assistance functions. Since endoscopic images are always available, this sensor input can be used to localize the instruments without special devices or robot kinematics. In this paper, we present an image-based markerless 3D tracking of different da Vinci instruments in near real-time without an explicit model. The method is based on different visual cues to segment the instrument tip, calculates a tip point and uses a multiple object particle filter for tracking. The accuracy and robustness is evaluated with in vivo data.

Speidel, S.; Kuhn, E.; Bodenstedt, S.; Röhl, S.; Kenngott, H.; Müller-Stich, B.; Dillmann, R.

2014-03-01

208

A PEG-DA microfluidic device for chemotaxis studies  

NASA Astrophysics Data System (ADS)

The study of cells in a well-defined and chemically programmable microenvironment is essential for a complete and fundamental understanding of the cell behaviors with respect to specific chemical compounds. Flow-free microfluidic devices that generate quasi-steady chemical gradients (spatially varying but temporally constant) have been demonstrated as effective chemotaxis assay platforms due to dissociating the effect of chemical cues from mechanical shear forces caused by fluid flow. In this work, we demonstrate the fabrication and characterization of a flow-free microfluidic platform made of polyethylene glycol diacrylate (PEG-DA) hydrogel. We have demonstrated that the mass transport properties of these devices can be customized by fabricating them from PEG-DA gels of four distinct molecular weights. In contrast to microfluidic devices developed using soft lithography; this class of devices can be realized using a more cost-effective approach of direct photopolymerization with fewer microfabrication steps. This microfluidic platform was tested by conducting a quantitative study of the chemotactic behavior of Escherichia coli (E. coli) RP437, a model microorganism, in presence of the chemo-effector, casamino-acids. Using the microfabrication and characterization methodology presented in this work, microfluidic platforms with well-defined and customizable diffusive properties can be developed to accommodate the study of a wide range of cell types.

Aziz Traore, Mahama; Behkam, Bahareh

2013-08-01

209

Chandra Confirmation of a Pulsar Wind Nebula in DA 495  

NASA Technical Reports Server (NTRS)

As part of a multiwavelength study of the unusual radio supernova remnant DA 495, we present observations made with the Chandra X-ray Observatory. Imaging and spectroscopic analysis confirms the previously detected X-ray source at the heart of the annular radio nebula, establishing the radiative properties of two key emission components: a soft unresolved source with a blackbody temperature of 1 MK consistent with a neutron star, surrounded by a nontherma1 nebula 40" in diameter exhibiting a power-law spectrum with photon index Gamma = 1.63, typical of a pulsar wind nebula. Morphologically, the nebula appears to be slightly extended along a direction, in projection on the sky, previously demonstrated to be of significance in radio and ASCA observations; we argue that this represents the orientation of the pulsar spin axis. At smaller scales, a narrow X-ray feature is seen extending out 5" from the point source, but energetic arguments suggest that it is not the resolved termination shock of the pulsar wind against the ambient medium. Finally, we argue based on synchrotron lifetimes in the nebular magnetic field that DA 495 represents the first example of a pulsar wind nebula in which electromagnetic flux makes up a significant part, together with particle flux, of the neutron star's wind.

Arzoumanian, Z.; Safi-Harb, S.; Landecker, T.L.; Kothes, R.; Camilo, F.

2008-01-01

210

SBS TDMA-DA system with VAC and DAC  

NASA Astrophysics Data System (ADS)

This paper describes many of the design considerations involved in developing the demand assignment (DA) subsystem of the TDMA satellite communication system for Satellite Business Systems. Each earth station has a satellite communications controller (SCC) which requests capacity to meet current voice and data traffic demands. A central reference station frequently reallocates capacity based on the requests of all the earth stations in a network. To minimize the amount of satellite capacity required, the SCC has a circuit-switching capability for voice calls as well as for digital data calls. Furthermore, the SCC employs voice activity compression (VAC) and data activity compression (DAC), in which the amount of capacity requested is based on measured average speech activity as well as the number of off-hook voice ports and the number of off-hook data ports. Data calls are queued on a first-come, first-served basis when capacity is not immediately available. The reference station distributes excess capacity according to a nonlinear table lookup procedure so that the voice call blocking probability is equalized across the network. The DA system makes much more efficient use of satellite transmission capacity than a design with fixed-capacity trunk routes.

Goode, B.

1984-11-01

211

Immunoreactivity of the Mycobacterium avium subsp. paratuberculosis 19-kDa lipoprotein  

PubMed Central

Background The Mycobacterium tuberculosis 19-kDa lipoprotein has been reported to stimulate both T and B cell responses as well as induce a number of Th1 cytokines. In order to evaluate the Mycobacterium avium subsp. paratuberculosis (M. avium subsp. paratuberculosis) 19-kDa lipoprotein as an immunomodulator in cattle with Johne's disease, the gene encoding the 19-kDa protein (MAP0261c) was analyzed. Results MAP0261c is conserved in mycobacteria, showing a 95% amino acid identity in M. avium subspecies avium, 84% in M. intracellulare and 76% in M. bovis and M. tuberculosis. MAP0261c was cloned, expressed, and purified as a fusion protein with the maltose-binding protein (MBP-19 kDa) in Escherichia coli. IFN-? production was measured from 21 naturally infected and 9 control cattle after peripheral blood mononuclear cells (PBMCs) were stimulated with a whole cell lysate (WCL) of M. avium subsp. paratuberculosis or the recombinant MBP-19 kDa. Overall, the mean response to MBP-19 kDa was not as strong as the mean response to the WCL. By comparison, cells from control, non-infected cattle did not produce IFN-? after stimulation with either WCL or MBP-19 kDa. To assess the humoral immune response to the 19-kDa protein, sera from cattle with clinical Johne's disease were used in immunoblot analysis. Reactivity to MBP-19 kDa protein, but not MBP alone, was observed in 9 of 14 infected cattle. Antibodies to the 19-kDa protein were not observed in 8 of 9 control cows. Conclusions Collectively, these results demonstrate that while the 19-kDa protein from M. avium subsp. paratuberculosis stimulates a humoral immune response and weak IFN-? production in infected cattle, the elicited responses are not strong enough to be used in a sensitive diagnostic assay. PMID:15663791

Huntley, Jason FJ; Stabel, Judith R; Bannantine, John P

2005-01-01

212

TnE em Congressos XXXIII Reunio Anual da SAB Boletim da Sociedade Astronmica Brasileira (2007) Vol. 27, No.1, p. 234  

E-print Network

) Vol. 27, No.1, p. 234 DESENVOLVIMENTO COMPUTACIONAL PARA OBSERVA��ES ASTRON�MICAS REMOTAS Ana Lúcia da aumentaram sua confiabilidade. O desenvolvimento computacional ­ em código aberto ­ é baseado na linguagem

213

COMO SE CONECTAR A REDE WIFI DA BIBLIOTECA Para conectar a rede WIFI da biblioteca a partir do notebook, siga os passos abaixo  

E-print Network

1 COMO SE CONECTAR A REDE WIFI DA BIBLIOTECA Para conectar a rede WIFI da biblioteca a partir do controle. #12;2 2º Passo: - Procure o ícone "Rede e Internet" ou o ícone "Conexões de rede"; - Ao abrir-se a internet" abrirá uma janela com os tipos de conexões existentes, você deverá optar pela rede sem fio. #12

Paraná, Universidade Federal do

214

Bovine Prion Is Endocytosed by Human Enterocytes via the 37 kDa/67 kDa Laminin Receptor  

PubMed Central

Some forms of transmissible spongiform encephalopathies result from oral infection. We have thus analyzed the early mechanisms that could account for an uptake of infectious prion particles by enterocytes, the major cell population of the intestinal epithelium. Human Caco-2/TC7 enterocytes cultured on microporous filters were incubated with different prion strains and contaminated brain homogenates in the apical compartment. Internalization of infectious particles was analyzed by Western blotting and immunofluorescence. We observed internalization by enterocytes of prion particles from bovine spongiform encephalopathy brain homogenates but not from mouse-adapted scrapie-strain brain homogenates or purified bovine spongiform encephalopathy scrapie-associated fibrils. Bovine prion particles were internalized via endocytosis within minutes of infection and were associated with subapical vesicular structures related to early endosomes. The endocytosis of the infectious bovine PrPSc was reduced by preincubating the cells with an anti-LRP/LR blocking antibody, identifying the 37 kDa/67 kDa laminin receptor (LRP/LR), which is apically expressed in Caco-2/TC7 cells, as the receptor for the infectious prion protein. Altogether, our results underscore a potential role of enterocytes in the absorption of bovine prions during oral infection through specific LRP/LR-dependent endocytosis. PMID:16192638

Morel, Etienne; Andrieu, Thibault; Casagrande, Fabrice; Gauczynski, Sabine; Weiss, Stefan; Grassi, Jacques; Rousset, Monique; Dormont, Dominique; Chambaz, Jean

2005-01-01

215

The 37kDa/67kDa Laminin Receptor acts as a receptor for A?42 internalization  

PubMed Central

Neuronal loss is a major neuropathological hallmark of Alzheimer's disease (AD). The associations between soluble A? oligomers and cellular components cause this neurotoxicity. The 37?kDa/67?kDa laminin receptor (LRP/LR) has recently been implicated in A? pathogenesis. In this study the mechanism underlying the pathological role of LRP/LR was elucidated. Försters Resonance Energy Transfer (FRET) revealed that LRP/LR and A? form a biologically relevant interaction. The ability of LRP/LR to form stable associations with endogenously shed A? was confirmed by pull down assays and A?-ELISAs. Antibody blockade of this association significantly lowered A?42 induced apoptosis. Furthermore, antibody blockade and shRNA mediated downregulation of LRP/LR significantly hampered A?42 internalization. These results suggest that LRP/LR is a receptor for A?42 internalization, mediating its endocytosis and contributing to the cytotoxicity of the neuropeptide by facilitating intra-cellular A?42 accumulation. These findings recommend anti-LRP/LR specific antibodies and shRNAs as potential therapeutic tools for AD treatment. PMID:24990253

Da Costa Dias, Bianca; Jovanovic, Katarina; Gonsalves, Danielle; Moodley, Kiashanee; Reusch, Uwe; Knackmuss, Stefan; Weinberg, Marc S.; Little, Melvyn; Weiss, Stefan F. T.

2014-01-01

216

Estratégias heurísticas da análise geométrica grega aplicadas na elaboração de textos didáticos  

Microsoft Academic Search

* Resumo: Os antigos geômetras gregos partilhavam de um método secreto de resolução que, graças à descrição de Pappus de Alexandria, ficamos sabendo que consistia de um movimento em busca de um princípio fundante, a análise, e de um movimento que partia deste princípio, a síntese. Embora os historiadores da matemática sejam unânimes no que concerne ao movimento dedutivo da

Antônio Jorge Soares

217

RESENHA OBRA: BIANCHETTI, LUCÍDIO; JANTSH, ARI. (ORGS). INTERDISCIPLINARIDADE: PARA ALÉM DA FILOSOFIA DO SUJEITO. PETRÓPOLIS: VOZES  

Microsoft Academic Search

A recente história da interdisciplinaridade no Brasil, apesar das freqüentes ilusões da moda, tem testemunhado o sentido de seriedade que tem animado o trabalho teórico e as inúmeras atividades práticas nos últimos cinco anos, dos quais produziram centenas de seminários, trabalhos, teses, dissertações, livros e artigos, na esperança de provar na prática o bem de suas intuições. Mas permanece sempre

César Augusto Soares da Costa

2009-01-01

218

TRIBUNAL REGIONAL FEDERAL DA 1 REGIO XIV CONCURSO PBLICO PARA PROVIMENTO DE CARGO DE  

E-print Network

Oliveira Passos, 6.55 / 10005509, Ana Lidia Silva Mello, 6.50 / 10006503, Ana Paula Antunes, 6.45 / 10006213, Ana Paula Candida Marinho, 4.00 / 10002515, Ana Paula da Silveira, 6.10 / 10004379, Ananda de Helia Benevides, 7.05 / 10006841, Anderson Santos da Silva, 7.75 / 10003361, Andre Antonio Souza Santos

Maier, Rudolf Richard

219

A Creative Approach to the Common Core Standards: The Da Vinci Curriculum  

ERIC Educational Resources Information Center

"A Creative Approach to the Common Core Standards: The Da Vinci Curriculum" challenges educators to design programs that boldly embrace the Common Core State Standards by imaginatively drawing from the genius of great men and women such as Leonardo da Vinci. A central figure in the High Renaissance, Leonardo made extraordinary contributions as a…

Chaucer, Harry

2012-01-01

220

O METRO E A CIDADE. Das representaes da causalidade integrao transporte/ordenamento em Paris.  

E-print Network

1 O METRO E A CIDADE. Das representações da causalidade à integração transporte/ordenamento em Paris. _____________________ Palavras-chave : metro ­ causalidade ­ avaliação ­ efeitos ­ infra entre a expansão do metro parisiense nos arredores da capital francesa e o tecido urbano e social do

Paris-Sud XI, Université de

221

Instituto Nacional de Cincia e Tecnologia de Matemtica Avano Global e Integrado da Matemtica Brasileira  

E-print Network

Federal do Pará. · Mauro de Lima Santos Universidade Federal da Paraíba. · João M. do � Universidade Fora)- Fabio Rodrigues Pereira- fabio.pereira@ufjf.edu.br Coordenadora da UFLA (Lavras)-Rita Broche

Solodov, Mikhail V.

222

32 CFR Appendix E to Part 623 - Surety Bond (DA Form 4881-3-R)  

Code of Federal Regulations, 2010 CFR

...2010-07-01 2010-07-01 true Surety Bond (DA Form 4881-3-R) E Appendix E to Part 623 National Defense Department...E Appendix E to Part 623—Surety Bond (DA Form 4881-3-R) EC24OC91.021 EC24OC91.022...

2010-07-01

223

A CLONAGEM HUMANA NUMA NOVA GRAMÁTICA CONSTITUCIONAL: A APLICABILIDADE PRÁTICA DO PRINCÍPIO DA DIGNIDADE HUMANA  

Microsoft Academic Search

Tendo em vista os recentes avanços da ciência, sobretudo na área de manipulação genética, a questão da clonagem humana surge como um dos grandes desafios a ser encarado. Nesse trabalho buscamos fazer uma análise não só jurídica, mas também técnica, ética e moral do tema, tendo como ponto de partida um estudo sobre a Bioética, passando pelo surgimento do Biodireito

Bernardo Abreu de Medeiros

224

Leonardo da Vinci and Stroke – Vegetarian Diet as a Possible Cause  

Microsoft Academic Search

Leonardo da Vinci (April 15, 1452 to May 2, 1519) was an Italian Renaissance architect, musician, anatomist, inventor, engineer, sculptor, geometer, and painter. It has been gleaned from the many available historical documents that da Vinci was a vegetarian who respected and loved animals, and that he suffered from right hemiparesis in the last 5 years of his life. A

Marta Altieri; Pina Troisi

2010-01-01

225

Pa?u Ayurv?da (veterinary medicine) in Garudapur??a.  

PubMed

The history of veterinary medicine is closely tied to the development of human medicine. Evidence of animal medicine has been found in ancient civilizations, such as those of the Hindu, Babylonians, Hebrews, Arabs, Greeks, and Romans. Ancient Indian literature in the form of the holy V?da, Pur?na, Br?hma?a, epics, etc. is flooded with information on animal care. The Pur??a are ancient scriptures discuss varied topics like devotion to God and his various aspects, traditional sciences like Ayurv?da, Jy?ti?a (Astrology), cosmology, concepts like dharma, karma, reincarnation and many others. The treatment of animal diseases using Ayurvedic medicine has been mentioned in Garudapur?na, Agnipur??a, Atri-samhit?, Matsyapur??a and many other texts. The Garudapur??a is one of the important S?ttvika pur?na, the subject matter is divided into two parts, viz. P?rvakha?da (first part) and an Uttarakha?da (subsequent part). Gav?yurv?da, Gaj?yurv?da narrated briefly and A?v?yurv?da described detailly in P?rvakha?da. PMID:19580108

Varanasi, Subhose; Narayana, A

2007-01-01

226

O CONCEITO DE EMANCIPAÇÃO COMO FUNDAMENTO PARA UMA TEORIA DA EDUCAÇÃO EM JÜRGEN HABERMAS  

Microsoft Academic Search

Neste breve artigo pretendemos apresentar elementos que possam ser sugestivos e indicativos para a fundamentação de uma teoria da educação a partir da compreensão do processo de esclarecimento enquanto processo de emancipação do homem na sociedade contemporânea. Sabemos que Jürgen Habermas propõe o recurso ao entendimento mútuo como meio para se chegar a um entendimento e se obter um consenso,

Bartolomeu Leite da Silva

2010-01-01

227

Confrontos e confluências entre a sociologia da lin guagem de Bourdieu e teorias lingüísticas  

Microsoft Academic Search

Resumo: Discussão das relações polêmicas que se estabelecer am entre a sociologia da linguagem de Bourdieu e lingüistas franceses, em to rno das noções de língua, comunicação e gramaticalidade. Palavras-chave: sociologia da linguagem, lingüística, língua, discu rso. Abstract: Discussion of the polemics relations between Bourdi eu's sociology of language and french linguists about the concepts of langue , communication and

Sheila Vieira de Camargo

2003-01-01

228

Pensar a natureza e o ambiente - alguns contributos a partir da Teoria das Representações Sociais  

Microsoft Academic Search

Resumo Este artigo apresenta dois estudos conduzidos em Portugal, sob a orientação da Teoria das Representações Sociais (TRS), que analisaram como os portugueses pensam e falam sobre o ambiente e a natureza. É primeiro apresentada uma perspectiva geral do campo de estudos das crenças e atitudes em relação ao ambiente e à natureza e são esboçadas as ideias da TRS

Paula Castro

2003-01-01

229

Robotic laparoscopic surgery: a comparison of the da Vinci and Zeus systems  

Microsoft Academic Search

Objectives. To evaluate two currently available robotic surgical systems in performing various urologic laparoscopic procedures in an acute porcine model.Methods. Robotic laparoscopic surgery was performed in 14 swine. Data were compared between the da Vinci Robotic System and the Zeus Robotic System.Results. During laparoscopic nephrectomy, the da Vinci System (n = 6) had a significantly shorter total operating room time

Gyung Tak Sung; Inderbir S Gill

2001-01-01

230

Page 1 of 4 Real-Time Visualization of the "da Vinci" Surgical Robot  

E-print Network

Page 1 of 4 Real-Time Visualization of the "da Vinci" Surgical Robot Dan Morris, Stanford) The "da Vinci" Surgical Robot allows a surgeon ­ controlling a robot from a manipulator console ­ to perform minimally invasive laparoscopic surgeries that would be difficult or impossible to perform

Salisbury, Kenneth

231

References: [1] Butts DA, Weng C, Jin JZ, Yeh CI, Lesica NA, Alonso JM, Stanley GB  

E-print Network

References: [1] Butts DA, Weng C, Jin JZ, Yeh CI, Lesica NA, Alonso JM, Stanley GB (2007) Temporal precision in the neural code and the time scales of natural vision. Nature 449: 92-5. [2] Butts DA, Weng C in the retina and LGN Daniel A. Butts1 , Alexander R. R. Casti2 1) Dept. of Biology and Program in Neuroscience

Butts, Daniel

232

76 FR 72087 - Special Conditions: Diamond Aircraft Industries, Model DA-40NG; Electronic Engine Control (EEC...  

Federal Register 2010, 2011, 2012, 2013, 2014

...which is a derivative of the model DA-40 currently approved...with the Austro Engine GmbH model E4 diesel engine and an increased...mechanical control system on the model DA-40NG airplane. The EEC...1309 and propulsion system capabilities and failure...

2011-11-22

233

76 FR 55293 - Special Conditions: Diamond Aircraft Industries, Model DA-40NG; Electronic Engine Control (EEC...  

Federal Register 2010, 2011, 2012, 2013, 2014

...which is a derivative of the model DA-40 currently approved...with the Austro Engine GmbH model E4 diesel engine and an increased...mechanical control system on the model DA-40NG airplane. The EEC...1309 and propulsion system capabilities and failure...

2011-09-07

234

R. Zingales -L'atomismo chimico L'atomismo chimico, da Dalton a Cannizzaro  

E-print Network

alchimisti in una scienza moderna, Antoine Laurent Lavoisier (1743-1794), per l'enfasi che diede sempre alla sia da Pierre Joseph Macquer (1718-1784), nel Dizionario di Chimica (2a ed, 1777), che da Antoine, coniugata a una geniale capa- cità di analisi e sintesi concettuale, Lavoisier si pose l'obiettivo di

Spagnolo, Filippo

235

Intramembrane translocation and posttranslational palmitoylation of the chloroplast 32-kDa herbicide-binding protein  

SciTech Connect

The 32-kDa herbicide-binding protein, a component of photosystem II, is synthesized as a membrane-associated 33.5-kDa precursor within the chloroplast. We show that membrane attachment of the precursor and processing to the 32-kDa form occur in the unstacked stromal lamellae. Once processed, the 32-kDa protein translocates, within the thylakoids, to the topologically distinct stacked granal lamellae. Posttranslational palmitoylation of the processed 32-kDa protein is also shown to occur. This modification takes place in a membrane-protected domain and is mainly confined to the protein assembled in the granal lamellae, where functional photosystem II centers are concentrated.

Mattoo, A.K.; Edelman, M.

1987-03-01

236

Evidence for a 12?kDa “Carrier Protein” for Natriuretic Hormone  

PubMed Central

The search for the elusive Na-K-ATPase-inhibiting natriuretic hormone continues. In this review, evidence is presented that isolating the carrier protein for natriuretic hormone from hypertensive plasma is a necessary first step before splitting off the final hormone. The carrier protein has a molecular weight of 12?kDa while the final hormone has a molecular weight of 408?Da. Both compounds inhibit Na-K-ATPase but the compound containing the carrier protein predominates. The question has been raised as to whether the carrier protein is in actuality proANF, a 17?kDa protein that can be split between a 14?kDa protein (the presumptive proANF) and the 3?kDa ANF. PMID:25477863

Gonick, Harvey C.

2014-01-01

237

OS EFEITOS DA APRENDIZAGEM PSICOMOTORA NO CONTROLE DAS ATIVIDADES DE LOCOMOÇÃO SOBRE OBSTÁCULOS EM CRIANÇAS COM DEFICIÊNCIA DA VISÃO THE EFFECTS OF PSYCHOMOTOR LEARNING ON THE CONTROL OF LOCOMOTION  

Microsoft Academic Search

RESUMO: considerando que a visão é um dos sistemas sensoriais mais importantes na locomoção pois fornece informação tanto do ambiente quanto da postura e dos movimentos corporais, este estudo analisou os efeitos de um programa de treinamento perceptivo-motor no controle das atividades de locomoção em seis crianças com deficiências da visão. Para tanto, realizou-se a avaliação da locomoção durante a

Luiz Cezar; Janine Eliza de Oliveira; Silva PASSOS; Luiz Gonçalves

238

Da venerd 28 marzo, per un giorno al mese, secondo il calendario riportato nel seguito il CAM (Centro Ambientale Mobile) di AMSA sar presente in Piazza Leonardo da Vinci per sensibilizzare il quartiere di  

E-print Network

(Centro Ambientale Mobile) di AMSA sarà presente in Piazza Leonardo da Vinci per sensibilizzare il Centro Ambientale Mobile di AMSA approda in Piazza Leonardo da Vinci Per ulteriori informazioni è informazione e comunicazione diretta tra AMSA ed i cittadini. La presenza del CAM in Piazza Leonardo da Vinci

239

70 DA WHITE DWARFS IDENTIFIED IN LAMOST PILOT SURVEY  

SciTech Connect

We present a spectroscopically identified catalog of 70 DA white dwarfs (WDs) from the LAMOST pilot survey. Thirty-five are found to be new identifications after cross-correlation with the Eisenstein et al. and Villanova catalogs. The effective temperature and gravity of these WDs are estimated by Balmer lines fitting. Most of them are hot WDs. The cooling times and masses of these WDs are estimated by interpolation in theoretical evolution tracks. The peak of the mass distribution is found to be {approx}0.6 M {sub Sun }, which is consistent with prior work in the literature. The distances of these WDs are estimated using the method of synthetic spectral distances. All of these WDs are found to be in the Galactic disk from our analysis of space motions. Our sample supports the expectation that WDs with high mass are concentrated near the plane of the Galactic disk.

Zhao, J. K.; Luo, A. L.; Zhao, G. [Key Laboratory of Optical Astronomy, National Astronomical Observatories, Chinese Academy of Sciences, Beijing 100012 (China); Oswalt, T. D., E-mail: zjk@bao.ac.cn, E-mail: gzhao@bao.ac.cn, E-mail: lal@bao.ac.cn, E-mail: toswalt@fit.edu [Physics and Space Science Department, Florida Institute of Technology, Melbourne, FL 32901 (United States)

2013-06-01

240

Leonardo da Vinci and the Art of Sculpture  

NSDL National Science Digital Library

This website from the Getty Museum accompanies the exhibition "Leonardo da Vinci and the Art of Sculpture: Inspiration and Invention", organized by the High Museum of Art, Atlanta, and on display in Los Angeles until June 20th, 2010. The website features a slide show with images of 11 works of art, some by Leonardo and some by other artists, including older artists who influenced Leonardo and his followers. An image of Donatello's Bearded Prophet, 1418-20, is accompanied by audio discussing Donatello's impact on Leonardo, while the last three slides examine the master/pupil relationship between Leonardo and a younger artist, Giovanni Francesco Rustici, 1475-1554. Visitors to the site can also listen to an introduction to the exhibition that lays out its overall intent from co-curator Julian Brooks.

241

DA White Dwarfs Observed in the LAMOST Pilot Survey  

NASA Astrophysics Data System (ADS)

A total of ~640, 000 objects from the LAMOST pilot survey have been publicly released. In this work, we present a catalog of DA white dwarfs (DAWDs) from the entire pilot survey. We outline a new algorithm for the selection of white dwarfs (WDs) by fitting Sérsic profiles to the Balmer H?, H?, and H? lines of the spectra, and calculating the equivalent width of the Ca II K line. Two thousand nine hundred sixty-four candidates are selected by constraining the fitting parameters and the equivalent width of the Ca II K line. All the spectra of candidates are visually inspected. We identify 230 DAWDs (59 of which are already included in the Villanova and SDSS WD catalogs), 20 of which are DAWDs with non-degenerate companions. In addition, 128 candidates are classified as DAWDs/subdwarfs, which means the classifications are ambiguous. The result is consistent with the expected DAWD number estimated based on the LEGUE target selection algorithm.

Zhang, Yue-Yang; Deng, Li-Cai; Liu, Chao; Lépine, Sebastien; Newberg, Heidi Jo; Carlin, Jeffrey L.; Carrell, Kenneth; Yang, Fan; Gao, Shuang; Xu, Yan; Li, Jing; Zhang, Hao-Tong; Zhao, Yong-Heng; Luo, A.-Li; Bai, Zhong-Rui; Yuan, Hai-Long; Jin, Ge

2013-08-01

242

Leonardo da Vinci: the search for the soul.  

PubMed

The human race has always contemplated the question of the anatomical location of the soul. During the Renaissance the controversy crystallized into those individuals who supported the heart ("cardiocentric soul") and others who supported the brain ("cephalocentric soul") as the abode for this elusive entity. Leonardo da Vinci (1452-1519) joined a long list of other explorers in the "search for the soul." The method he used to resolve this anatomical problem involved the accumulation of information from ancient and contemporary sources, careful notetaking, discussions with acknowledged experts, and his own personal search for the truth. Leonardo used a myriad of innovative methods acquired from his knowledge of painting, sculpture, and architecture to define more clearly the site of the "senso comune"--the soul. In this review the author examines the sources of this ancient question, the knowledge base tapped by Leonardo for his personal search for the soul, and the views of key individuals who followed him. PMID:9817431

Del Maestro, R F

1998-11-01

243

As redes universitrias de difuso das cincias matemticas como fator de desenvolvimento da perspectiva. Uma agenda de pesquisa  

E-print Network

As redes universitárias de difusão das ciências matemáticas como fator de desenvolvimento da)" #12;AS REDES UNIVERSITÁRIAS DA DIFUS�O DA PERSPECTIVA 2 Ghiberti enumera vinte intenções visível (não

Paris-Sud XI, Université de

244

11 CFR 111.11 - Written questions under order (2 U.S.C. 437d(a)(1)).  

Code of Federal Regulations, 2012 CFR

...Written questions under order (2 U.S.C. 437d(a)(1)). 111.11 Section...GENERAL COMPLIANCE PROCEDURE (2 U.S.C. 437g, 437d(a)) Enforcement § 111...Written questions under order (2 U.S.C. 437d(a)(1)). The...

2012-01-01

245

11 CFR 111.11 - Written questions under order (2 U.S.C. 437d(a)(1)).  

Code of Federal Regulations, 2013 CFR

...Written questions under order (2 U.S.C. 437d(a)(1)). 111.11 Section...GENERAL COMPLIANCE PROCEDURE (2 U.S.C. 437g, 437d(a)) Enforcement § 111...Written questions under order (2 U.S.C. 437d(a)(1)). The...

2013-01-01

246

11 CFR 111.14 - Witness fees and mileage (2 U.S.C. 437d(a)(5)).  

Code of Federal Regulations, 2011 CFR

...false Witness fees and mileage (2 U.S.C. 437d(a)(5)). 111.14 Section...GENERAL COMPLIANCE PROCEDURE (2 U.S.C. 437g, 437d(a)) Enforcement § 111.14 Witness fees and mileage (2 U.S.C. 437d(a)(5)). Witnesses...

2011-01-01

247

11 CFR 111.14 - Witness fees and mileage (2 U.S.C. 437d(a)(5)).  

Code of Federal Regulations, 2013 CFR

...true Witness fees and mileage (2 U.S.C. 437d(a)(5)). 111.14 Section...GENERAL COMPLIANCE PROCEDURE (2 U.S.C. 437g, 437d(a)) Enforcement § 111.14 Witness fees and mileage (2 U.S.C. 437d(a)(5)). Witnesses...

2013-01-01

248

Listaxe provisoria de persoas admitidas da convocatoria '[Cod. 2030] Bolsas de formacin na rea de calidade e  

E-print Network

1. 2. 3. 4. Listaxe provisoria de persoas admitidas da convocatoria '[Cod. 2030] Bolsas de o prazo de presentación de solicitudes para a selección de bolseiros da convocatoria '[Cod. 2030,7081 #12;1. 2. 3. 4. 5. 6. Listaxe provisoria de persoas admitidas da convocatoria '[Cod. 1035] Bolsas de

Fraguela, Basilio B.

249

NOTE PER RICHIESTA DUPLICATO PERGAMENA 1. Compilare la domanda di rilascio duplicato pergamena con marca da bollo di  

E-print Network

Sviluppo e Rapporti con le Imprese ­ Servizio Offerta Formativa Post Laurea ­ Piazza Leonardo da Vinci, 32 Offerta Formativa Post Laurea in Piazza Leonardo da Vinci, 32 ­ Padiglione Nord ­ 1° piano ­ Milano Ritiro titolare presso il Servizio Offerta Formativa e Post Laurea in Piazza Leonardo da Vinci, 32 ­ Padiglione

250

43 kDa and 66 kDa, two blood stage antigens induce immune response in Plasmodium berghei malaria.  

PubMed

The hunt for an effective vaccine against malaria still continues. Several new target antigens as candidates for vaccine design are being explored and tested for their efficacy. In the present study the sera from mice immunized with 24,000 x g fraction of Plasmodium berghei has been used to identify highly immunogenic blood stage antigens. The protective antibodies present in immune sera were covalently immobilized on CNBr activated sepharose 4B and used for affinity chromatography purification of antigens present in blood stages of P. berghei. Two polypeptides of 66 and 43 kDa molecular weights proved to be highly immunogenic. They exhibited a strong humoral immune response in mice as evident by high titres in ELISA and IFA. Protective immunity by these two antigens was apparent by in vivo and in vitro studies. These two proteins could further be analysed and used as antigens in malaria vaccine design. PMID:25141540

Pirta, Chhaya; Banyal, H S

2014-08-01

251

The immune response to 52-kDa Ro and 60-kDa Ro is linked in experimental autoimmunity.  

PubMed

Clustering of autoantibody specificities is a consistent finding in patients with systemic autoimmune diseases. Patients with Sjögren's syndrome frequently have autoantibodies to La, 60-kDa Ro(SS-A) protein (Ro60), and 52-kDa Ro(SS-A) protein (Ro52). In the case of anti-Ro60 and anti-La, there is evidence that these specificities occur together because of the physical association of the Ro60 and La proteins that form a ribonucleoprotein particle (RNP). Thus, the autoantibody response may spread from a single epitope to involve new epitopes located within other components of the RNP. The physical association of Ro52 with the Ro/La RNP has remained controversial, implying that Abs to Ro52 are not a consequence of intermolecular spreading and may be triggered independently of the anti-Ro60 response. To examine this relationship of the immune response to Ro52 and Ro60, mice were immunized with recombinant Ro52, Ro60, or La, and examined for autoantibody production. Immunization with Ro52 resulted in rapid, high titer Ab production to Ro52, followed 7 to 14 days later by lower titer autoantibody production to Ro60. Immunization with Ro60 led to anti-Ro60, which was also followed 7 to 14 days later by a lower titer anti-Ro52 response. Cross-reactivity of affinity-purified Abs from immune mouse sera was not observed. These observations suggest that the autoimmune responses to Ro60 and Ro52 are linked intrinsically, despite previous evidence suggesting they are not associated in vivo. The mechanism of linkage remains unclear, but the data are most consistent with some physical association of Ro52 and Ro60 allowing autoimmunization, presumably as a result of normal cell turnover or specific injury in vivo. PMID:8871672

Keech, C L; Gordon, T P; McCluskey, J

1996-10-15

252

Endogenous dopamine (DA) modulates (3H)spiperone binding in vivo in rat brain  

SciTech Connect

(3H)spiperone (SPI) binding in vivo, biochemical parameters and behavior were measured after modulating DA levels by various drug treatments. DA releasers and uptake inhibitors increased SPI binding in rat striatum. In other brain areas, the effects were variable, but only the pituitary remained unaffected. Surprisingly, nomifensine decreased SPI binding in frontal cortex. The effects of these drugs were monitored by measuring DA, serotonin (5-HT) and their metabolites in the same rats. The increased SPI binding in striatum was parallel to the locomotor stimulation with the following rank order: amfonelic acid greater than nomifensine greater than D-amphetamine greater than or equal to methylphenidate greater than amineptine greater than bupropion. Decreasing DA levels with reserpine or alpha-methyl-para-tyrosine reduced SPI binding by 45% in striatum only when both drugs were combined. In contrast, reserpine enhanced SPI binding in pituitary. Thus, the amount of releasable DA seems to modulate SPI binding characteristics. It is suggested that in vivo, DA receptors are submitted to dynamic regulation in response to changes in intrasynaptic concentrations of DA.

Bischoff, S.; Krauss, J.; Grunenwald, C.; Gunst, F.; Heinrich, M.; Schaub, M.; Stoecklin, K.V.; Vassout, A.; Waldmeier, P.; Maitre, L. (Research Department, CIBA-GEIGY Ltd., Basel (Switzerland))

1991-01-01

253

Tão perto de casa, tão longe de nós: etnografia das novas margens no centro da urbe  

PubMed Central

Philippe Bourgois é, desde 2007, “Richard Perry University professor” no Departamento de Antropologia e de Medicina Familiar e de Práticas Comunitárias na Universidade da Pensilvânia. Esteve durante largos anos ligado ao Departamento de Antropologia, História e Medicina Social da Universidade da Califórnia, São Francisco. A publicação, em 1995, de In Search of Respect: Selling Crack in El Barrio1 projectaria o seu nome muito para além dos Estados Unidos: uma etnografia no coração porto-riquenho do Harlem, em torno dos actores e dos ambientes da venda de crack. Seguir-se-ia um longo trabalho de terreno em acampamentos de dependentes de heroína em São Francisco, orientando o seu trabalho para as formas mais radicais da pobreza e da marginalidade nos EUA. É deste trabalho de terreno que sai o seu último livro, Righteous Dopefiend2. Em Junho de 2007 esteve em Lisboa para participar na 3.a edição do “Ethnografeast”. Foi então que aproveitámos a oportunidade para ouvir um percurso invulgar contado pelo próprio: uma longa conversa no Hotel Zurique, cujo nome só vem ao caso por evocar o país onde passou uma parte da infância. PMID:22013286

Fernandes, Por Luís

2011-01-01

254

Vectra DA for the objective measurement of disease activity in patients with rheumatoid arthritis.  

PubMed

Quantitative and regular assessment of disease activity in rheumatoid arthritis (RA) is required to achieve treatment targets such as remission and to optimize clinical outcomes. To assess inflammation accurately, predict joint damage and monitor treatment response, a measure of disease activity in RA should reflect the pathological processes resulting in irreversible joint damage and functional disability. The Vectra DA blood test is an objective measure of disease activity for patients with RA. Vectra DA provides an accurate, reproducible score on a scale of 1 to 100 based on the concentrations of 12 biomarkers that reflect the pathophysiologic diversity of RA. The analytical validity, clinical validity, and clinical utility of Vectra DA have been evaluated for patients with RA in registries and prospective and retrospective clinical studies. As a biomarker-based instrument for assessing disease activity in RA, the Vectra DA test can help monitor therapeutic response to methotrexate and biologic agents and assess clinically challenging situations, such as when clinical measures are confounded by non-inflammatory pain from fibromyalgia. Vectra DA scores correlate with imaging of joint inflammation and are predictive for radiographic progression, with high Vectra DA scores being associated with more frequent and severe progression and low scores being predictive for non-progression. In summary, the Vectra DA score is an objective measure of RA disease activity that quantifies inflammatory status. By predicting risk for joint damage more effectively than conventional clinical and laboratory measures, it has the potential to complement these measures and optimise clinical decision making. PMID:25365086

Segurado, O G; Sasso, E H

2014-01-01

255

Therapeutic effect of infused Fluosol-DA/carbogen with ephedrine, flunarizine, or nitroprusside  

SciTech Connect

The perfluorochemical emulsion Fluosol-DA plus carbogen breathing has been shown to increase the effectiveness of radiation therapy in preclinical solid tumors when the emulsion was administered by i.v. bolus injection. Much of the enhancement in tumor radiation response was lost when the emulsion was administered slowly. The authors hypothesized that an increase in tumor perfusion resulted when Fluosol-DA was administered rapidly. In the present study, the [alpha]/[beta] agonist ephedrine, the Ca[sup 2+] channel blocker flunarizine and the nitric oxide producing vasodilating drug nitroprusside have been tested. Ephedrine administration resulted in a decrease in the radiation plus Fluosol-DA [+-] carbogen antitumor effects in both the Lewis lung carcinoma and FSaIIC tumor systems. In contrast, flunarizine administration resulted in an increase in the efficacy of the radiation plus carbogen and the radiation plus Fluosol-DA/carbogen in both emulsion was given rapidly. Even with flunarizine administration Fluosol-DA delivered slowly was less effective than when the emulsion was given rapidly. Flunarizine with Fluosol-DA infused i.v. over 30 min followed by carbogen breathing prior to and during radiation therapy resulted in a 1.7-1.6-fold increase in response compared with 2.4-2.2-fold with Fluosol-DA administered by injection i.v. and carbogen breathing prior to and during radiation therapy using growth delay of the Lewis lung carcinoma. The effects of nitroprusside were complex. This drug had considerably more effect at 10 Gy than at higher radiation doses. These studies suggest that Fluosol-DA given by i.v. injection may increase tumor perfusion and that a drug like flunarizine may be beneficial if the Fluosol-DA is administered slowly followed by carbogen breathing and radiation therapy. 45 refs., 4 figs.

Teicher, B.A.; Holden, S.A.; Northey, D.; Dewhirst, M.W.; Herman, T.S.

1993-04-30

256

Porphyromonas gulae 41-kDa fimbriae induced osteoclast differentiation and cytokine production.  

PubMed

Porphyromonas gulae is considered to be associated with canine periodontitis. We have previously reported that the P. gulae American Type Culture Collection (ATCC) 51700 comprised 41-kDa fimbriae. The purpose of the present study was to demonstrate the roles of 41-kDa fimbrial protein in periodontal disease. In this study, we examined the involvement of the 41-kDa fimbrial protein in osteoclast differentiation and cytokine production in murine macrophages. Furthermore, alveolar bone resorption induced by P. gulae infection in rats was evaluated. To estimate osteoclast differentiation, bone marrow cells and MC3T3-G2/PA6 cells were cultured with or without the 41-kDa fimbrial protein for 7 days. BALB/c mouse peritoneal macrophages were stimulated with the 41-kDa fimbrial protein, and the levels of interleukin (IL)-1? and tumor necrosis factor (TNF)-? production were determined by enzyme-linked immunosorbent assay. Osteoclast differentiation was significantly enhanced by treatment with the 41-kDa fimbrial protein in a dose-dependent manner. The total area of pits formed on the dentine slices with osteoclasts incubated with the 41-kDa fimbrial protein was significantly greater than that of the control. The purified 41-kDa fimbrial protein induced IL-1? and TNF-? production in BALB/c mouse peritoneal macrophages after 6 hr of incubation in a dose-dependent manner. The bone loss level in rats infected with P. gulae was significantly higher than that of the sham-infected rats. These results suggest that P. gulae 41-kDa fimbriae play important roles in the pathogenesis of periodontal disease. PMID:25421499

Sasaki, Haruka; Watanabe, Kiyoko; Toyama, Toshizo; Koyata, Yasunori; Hamada, Nobushiro

2014-11-25

257

Leonardo Da Vinci and stroke - vegetarian diet as a possible cause.  

PubMed

Leonardo da Vinci (April 15, 1452 to May 2, 1519) was an Italian Renaissance architect, musician, anatomist, inventor, engineer, sculptor, geometer, and painter. It has been gleaned from the many available historical documents that da Vinci was a vegetarian who respected and loved animals, and that he suffered from right hemiparesis in the last 5 years of his life. A vegetarian diet has both positive and negative influences on the cerebrovascular system. In this report, a possible relation between a vegetarian diet and stroke is discussed from various perspectives as related to Leonardo da Vinci's stroke. PMID:20375518

Oztürk, Serefnur; Altieri, Marta; Troisi, Pina

2010-01-01

258

DaVinci Canvas: A Telerobotic Surgical System with Integrated, Robot-Assisted, Laparoscopic Ultrasound Capability  

Microsoft Academic Search

\\u000a We present daVinci Canvas: a telerobotic surgical system with integrated robot-assisted laparoscopic ultrasound capability.\\u000a DaVinci Canvas consists of the integration of a rigid laparoscopic ultrasound probe with the daVinci robot, video tracking\\u000a of ultrasound probe motions, endoscope and ultrasound calibration and registration, autonomous robot motions, and the display\\u000a of registered 2D and 3D ultrasound images. Although we used laparoscopic liver

Joshua Leven; Darius Burschka; Rajesh Kumar; Gary Zhang; Steve Blumenkranz; Michael Awad; Gregory D. Hager; Mike Marohn; Michael A. Choti; Christopher J. Hasser; Russell H. Taylor

2005-01-01

259

69-kDa and 100-kDa isoforms of interferon-induced (2'-5')oligoadenylate synthetase exhibit differential catalytic parameters.  

PubMed

The (2'-5')oligoadenylate synthetase represents a family of interferon-induced proteins which when activated by double-stranded (ds)RNA polymerizes ATP into 2'-5'-linked oligomers with the general formula pppA(2'p5'A)n, where n > 1, which for convenience are referred to as 2-5A. We studied here the influence of pH, dsRNA concentration and time on oligomeric composition of 2-5A synthesized by purified 69-kDa and 100-kDa isoforms of (2'-5')oligo(adenylate) synthetase. In optimal conditions for activity, the 69-kDa form synthesized higher oligomers of 2-5A molecules whereas the 100 kDa form synthesized preferentially dimeric molecules, which are known not to be functional for the activation of RNase L. This difference does not reflect a differential affinity of the enzymes for the preformed 2-5A dimer, which is found to be a very poor substrate for both enzymes. This latter strongly suggests that the mechanism of elongation is more likely processive. Moreover, we show that both isoforms have efficient nucleotidyl-transferase activity and provide evidence that, in optimized conditions, GTP can be used alone as substrate by these enzymes to generate pppG2'p5'G. Our results clearly demonstrate that the 69-kDa and 100-kDa forms of (2'-5')oligoadenylate synthetase manifest various differential catalytic activities, and favor the hypothesis that these enzymes might have other functions in the cell besides those in the 2-5A system. PMID:9346316

Marié, I; Blanco, J; Rebouillat, D; Hovanessian, A G

1997-09-01

260

O IMPACTO DA AIDS NA PRÁTICA DE ENFERMAGEM: UM PROBLEMA DE SAÚDE PÚBLICA THE IMPACT OF AIDS IN NURSING PRACTICE: A PUBLIC HEALTH PROBLEM  

Microsoft Academic Search

RESUMO Introdução: o vírus da hepatite B foi reconhecido como possível de transmissão ocupacional bem antes do vírus da imunodeficiência adquirida (HIV), porém, foi com o advento da aids que os trabalhadores de enfermagem passaram a se preocupar com a sua prática, assim como com a utiliza- ção de medidas preventivas. Apesar de os vírus da hepatite B e C

Elucir Gir; Marinésia A Prado; Silvia RMS Canini; Miyeko Hayashida

261

DA CONSEGNARE A MANO O SPEDIRE PER POSTA A SERVIZIO OFFERTA FORMATIVA POST LAUREA-POLITECNICO DI MILANO CAMPUS LEONARDO EDIFICO 2 PIAZZA  

E-print Network

MILANO ­ CAMPUS LEONARDO ­ EDIFICO 2 ­ PIAZZA LEONARDO DA VINCI, 32 ­ 20133 MILANO - ITALY Marca da bollo Formativa Post Laurea ­ Campus Leonardo ­ Piazza Leonardo da Vinci, 32 ­ Padiglione Nord ­ Edificio 2 diDA CONSEGNARE A MANO O SPEDIRE PER POSTA A SERVIZIO OFFERTA FORMATIVA POST LAUREA- POLITECNICO DI

262

49 CFR 178.58 - Specification 4DA welded steel cylinders for aircraft use.  

Code of Federal Regulations, 2014 CFR

...DOT 4DA is a welded steel sphere (two seamless hemispheres) or a circumferentially welded cylinder (two seamless drawn shells) with a water capacity...specified for American Standard taper pipe threads. (iii) Straight...

2014-10-01

263

Morfologia do sistema reprodutor masculino da preguiça-de-coleira (Bradypus torquatus, Illiger, 1811).  

E-print Network

??Os Bichos-Preguiça são mamíferos (Classe Mammalia) da ordem Xenarthra (ou Edentata) Utilizamos nesta pesquisa preguiças-de-coleira (Bradypus torquatus) sendo seis machos e uma fêmea de diferentes… (more)

Daniele dos Santos Martins

2003-01-01

264

32 CFR 516.14 - Service of process on DA or Secretary of Army.  

Code of Federal Regulations, 2010 CFR

... National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY AID OF CIVIL AUTHORITIES AND PUBLIC RELATIONS LITIGATION Service of Process § 516.14 Service of process on DA or Secretary of Army. The Chief,...

2010-07-01

265

História da ciência no estudo de modelos atômicos em livros didáticos de química.  

E-print Network

??Dissertação (mestrado)—Universidade de Brasília, Faculdade de Educação, Programa de Pós-Graduação em Educação, 2011. Esta dissertação tem por objetivo identificar a História da Ciência apresentada nos… (more)

Chaves, Lígia Maria Martinho Pereira

2011-01-01

266

DA WHITE DWARFS OBSERVED IN THE LAMOST PILOT SURVEY  

SciTech Connect

A total of {approx}640, 000 objects from the LAMOST pilot survey have been publicly released. In this work, we present a catalog of DA white dwarfs (DAWDs) from the entire pilot survey. We outline a new algorithm for the selection of white dwarfs (WDs) by fitting Sersic profiles to the Balmer H{beta}, H{gamma}, and H{delta} lines of the spectra, and calculating the equivalent width of the Ca II K line. Two thousand nine hundred sixty-four candidates are selected by constraining the fitting parameters and the equivalent width of the Ca II K line. All the spectra of candidates are visually inspected. We identify 230 DAWDs (59 of which are already included in the Villanova and SDSS WD catalogs), 20 of which are DAWDs with non-degenerate companions. In addition, 128 candidates are classified as DAWDs/subdwarfs, which means the classifications are ambiguous. The result is consistent with the expected DAWD number estimated based on the LEGUE target selection algorithm.

Zhang Yueyang; Deng Licai; Liu Chao; Carrell, Kenneth; Yang Fan; Gao Shuang; Xu Yan; Li Jing; Zhang Haotong; Zhao Yongheng; Luo Ali; Bai Zhongrui; Yuan Hailong [Key Lab for Optical Astronomy, National Astronomical Observatories, Chinese Academy of Sciences, Beijing 100012 (China); Lepine, Sebastien [Department of Astrophysics, Division of Physical Sciences, American Museum of Natural History, Central Park West at 79th Street, New York, NY (United States); Newberg, Heidi Jo; Carlin, Jeffrey L. [Department of Physics, Applied Physics and Astronomy, Rensselaer Polytechnic Institute, 110 8th Street, Troy, NY 12180 (United States); Jin Ge [University of Science and Technology of China, Hefei 230026 (China)

2013-08-01

267

Da\\phi ne gamma-rays factory  

E-print Network

Gamma sources with high flux and spectral densities are the main requirements for new nuclear physics experiments to be performed in several worldwide laboratories and envisaged in the ELI-NP (Extreme Light Infrastructure-Nuclear Physics) project or in the IRIDE (Interdisciplinary Research Infrastructure with Dual Electron Linacs) proposals. The paper is focalized on an experiment of gamma photons production using Compton collisions between the DA\\Phi NE electron beam and a high average power laser pulse, amplified in a Fabry-P\\'erot optical resonator. The calculations show that the resulting gamma beam source has extremely interesting properties in terms of spectral density, energy spread and gamma flux comparable (and even better) with the last generation gamma sources. The energy of the gamma beam depends on the adopted laser wavelength and can be tuned changing the energy of the electron ring. In particular we have analyzed the case of a gamma factory tunable in the 2-9 MeV range. The main parameters of t...

Alesini, D; Variola, A; Guiducci, S; Zomer, F; Milardi, C; Zobov, M

2014-01-01

268

DA?NE operation with electron-cloud-clearing electrodes.  

PubMed

The effects of an electron cloud (e-cloud) on beam dynamics are one of the major factors limiting performances of high intensity positron, proton, and ion storage rings. In the electron-positron collider DA?NE, namely, a horizontal beam instability due to the electron-cloud effect has been identified as one of the main limitations on the maximum stored positron beam current and as a source of beam quality deterioration. During the last machine shutdown in order to mitigate such instability, special electrodes have been inserted in all dipole and wiggler magnets of the positron ring. It has been the first installation all over the world of this type since long metallic electrodes have been installed in all arcs of the collider positron ring and are currently used during the machine operation in collision. This has allowed a number of unprecedented measurements (e-cloud instabilities growth rate, transverse beam size variation, tune shifts along the bunch train) where the e-cloud contribution is clearly evidenced by turning the electrodes on and off. In this Letter we briefly describe a novel design of the electrodes, while the main focus is on experimental measurements. Here we report all results that clearly indicate the effectiveness of the electrodes for e-cloud suppression. PMID:25166811

Alesini, D; Drago, A; Gallo, A; Guiducci, S; Milardi, C; Stella, A; Zobov, M; De Santis, S; Demma, T; Raimondi, P

2013-03-22

269

Boso de Higgs recebe Nobel da Fsica no ano a seguir descoberta p29 Nobel da Fsica de 2013 para teoria  

E-print Network

Bosão de Higgs recebe Nobel da Física no ano a seguir à descoberta p29 #12;Nobel da Física de 2013 para teoria (e prática) do bosão de Higgs Prémio distinguiu o belga François Englert e o britânico Peter Higgs, dois dos físicos teóricos que, há quase 50 anos, postularam a existência de uma partícula

Instituto de Sistemas e Robotica

270

PARTICIPAÇÃO COMUNITÁRIA NO PLANEJAMENTO VIÁRIO DE ALGUNS BAIRROS DA CIDADE DE AMERICANA\\/SP 1  

Microsoft Academic Search

RESUMO O envolvimento da comunidade é um elemento fundamental para maior êxito no planejamento da arborização urbana. O presente trabalho teve os objetivos de, junto à população local, escolher espécies para plantio nas calçadas e colaborar no envolvimento das pessoas em solucionar os freqüentes problemas relacionados à educação ambiental. Na primeira fase constataram-se 2.551 indivíduos plantados, 76 espécies e 1.314

Luzia Ferreira da Silva; Andrea Volpe-Filik; Ana Maria Liner; Pereira Lima; Ferreira da Silva Filho

271

Temperature and Gravity Dependence of Trace Element Abundances in Hot DA White Dwarfs (94-EUVE-094)  

NASA Technical Reports Server (NTRS)

EUV spectroscopy has shown that DA white dwarfs hotter than about 45,000 K may contain trace heavy elements, while those hotter than about 50,000 K almost always have significant abundances of trace heavy elements. One of our continuing challenges is to identify and determine the abundances of these trace constituents, and then to relate the observed abundance patterns to the present conditions and previous evolutionary histories of the hot DA white dwarfs.

Finley, David S.

1998-01-01

272

Mtodo de Fibonacci Como no mtodo da "Golden Section" o procedimento de procura de Fibonacci faz  

E-print Network

Método de Fibonacci Como no método da "Golden Section" o procedimento de procura de Fibonacci faz incerteza varia duma iteração para outra. O procedimento é baseado na sequência de Fibonacci Fn{ } definida acontece com os métodos da procura dicotómica e de "Golden section", o método de Fibonacci requer que o

Instituto de Sistemas e Robotica

273

Seminario Informal (mas Formal!) 2006 Estrategias da Teoria de Reescrita em PVS  

E-print Network

4o Semin´ario Informal (mas Formal!) 2006 Estrat´egias da Teoria de Reescrita em PVS: considerac Teoria da Computac¸ ~ao Campus de Catal~ao & Departamento de Matem´atica Universidade Federal de Goi. A especificac¸ ~ao em PVS ´e organizada como uma colec¸ ~ao de Teorias. Uma Teoria ´e essencialmente feita de

Ayala-Rincón, Mauricio

274

Facultade de Ciencias da Educacin Mster Universitario en Direccin, Gestin e Innovacin de Instituciones Escolares y  

E-print Network

Facultade de Ciencias da Educación Máster Universitario en Dirección, Gestión e Innovación de Memoria de Verificación Facultad de Ciencias de la Educación Universidad de A Coruña Año 2013 #12;Facultade de Ciencias da Educación Máster Universitario en Dirección, Gestión e Innovación de Instituciones

Fraguela, Basilio B.

275

Facultade de Ciencias da Educacin Mster Universitario en Didcticas Especficas por la Universidad de A Corua  

E-print Network

Facultade de Ciencias da Educación Máster Universitario en Didácticas Específicas por la A CORU�A Memoria de Verificación Facultad de Ciencias de la Educación Universidad de A Coruña Año 2013 #12;Facultade de Ciencias da Educación Máster Universitario en Didácticas Específicas por la Universidad de

Fraguela, Basilio B.

276

Essential 170-kDa Subunit for Degradation of Crystalline Cellulose by Clostridium Cellulovorans Cellulase  

Microsoft Academic Search

The cellulase complex from Clostridium cellulovorans has been purified and its subunit composition determined. The complex exhibits cellulase activity against crystalline cellulose as well as carboxymethylcellulase (CMCase) and cellobiohydrolase activities. Three major subunits are present with molecular masses of 170, 100, and 70 kDa. The 100-kDa subunit is the major CMCase, although at least four other, minor subunits show CMCase

Oded Shoseyov; Roy H. Doi

1990-01-01

277

Efficient Synthesis of a 72-kDa Mitochondrial Polypeptide Using the Yeast Ty Expression System  

Microsoft Academic Search

Using the Ty system from yeast we report the efficient expression of a heterologous eukaryotic gene encoding a 72 kDa mitochondrial polypeptide. The pFM2IIBglII expression vector was initially modified for this purpose by inserting the factor Xaprotease cleavage site. TheTyAgene, which encodes the structural component of the yeast virus-like particles (VLPs), and the eukaryoticyst1 gene, encoding a 72 kDa mitochondrial

Stefanie Pöggeler; Christian Schwerk; Ute Kämper; Ulrich Kück

1996-01-01

278

Colquio em homenagem ao centenrio da morte de Henri Poincar Rio de Janeiro  

E-print Network

Colóquio em homenagem ao centenário da morte de Henri Poincaré Rio de Janeiro 27 a 30 de novembro Henri Poincaré (Université Nancy 2) Em 2012, ocorrerá o primeiro centenário da morte do matemático morte de Poincaré, além de ser uma merecida homenagem a um cientista-filósofo, cujas idéias ainda hoje

Solodov, Mikhail V.

279

In vitro degradation of the 32kDa PS II reaction centre protein  

SciTech Connect

The 32kDa thylakoid membrane protein is an integral component of the PS II reaction centre. The protein, although stable in the dark, undergoes light dependent turnover. Light from the UV, visible and far-red spectral regions induce 32kDa protein degradation. To better understand 32kDa protein metabolism, an in vitro degradation system is being developed. It consists of isolated thylakoid membranes than contain radiolabelled protein. The 32kDa protein is actively and specifically degraded when the thylakoid preparation is exposed to UV or visible radiation. The protein is stable in the dark. The herbicides (atrazine and DCMU) inhibit degradation in the in vitro system as they do in vivo. Additionally, several methods of isolating thylakoids are being compared to optimize the 32kDa protein degradation reaction. The preparations will be evaluated based on their ability to permit light dependent degradation of the 32kDa protein without affecting the other membrane components.

Eckenswiller, L.C.; Greenberg, B.M. (Univ. of Waterloo, Ontario (Canada))

1989-04-01

280

The sandfly fauna (Diptera: Psychodidae: Phlebotominae) of the Parque Estadual da Serra da Tiririca, Rio de Janeiro, Brazil  

PubMed Central

Cutaneous leishmaniasis (CL) in the state of Rio de Janeiro is sporadic and can be characterised as a peridomestic transmission that occurs in modified natural environments. The aim of this work was to study the fauna and ecological characteristics of sandflies in an environmentally protected area (the State Park of Serra da Tiririca) within the remnants of the Atlantic Forest in the municipalities of Niterói and Maricá and their possible relationship with leishmaniasis. Captures were performed using light traps during the night once a month for one year in both sylvatic environments and areas surrounding homes near the park. A total of 1,037 sandflies were captured, belonging to nine genera and 12 species: Evandromyia tupynambai (34.1%), Migonemyia migonei (20.6%), Brumptomyia cunhai (13.8%), Micropygomyia schreiberi (9.7%), Psathyromyia lanei (6.5%), Brumptomyia nitzulescui (5.7%), Evandromyia edwardsi (5.4%), Nyssomyia intermedia (2.8%), Evandromyia cortelezzii (0.6%), Pintomyia bianchigalatiae (0.5%), Lutzomyia longipalpis (0.2%) and Sciopemyia microps (0.1%). Both Mg. migonei and Ny. intermedia may be acting as vectors of CL in this area. PMID:24141956

Rodrigues, Andressa Alencastre Fuzari; Barbosa, Vanessa de Araújo; Andrade, José Dilermando; Brazil, Reginaldo Peçanha

2013-01-01

281

Vinpocetine and ?-tocopherol prevent the increase in DA and oxidative stress induced by 3-NPA in striatum isolated nerve endings.  

PubMed

Vinpocetine is a neuroprotective drug that exerts beneficial effects on neurological symptoms and cerebrovascular disease. 3-nitropropionic acid (3-NPA) is a toxin that irreversibly inhibits succinate dehydrogenase, the mitochondrial enzyme that acts in the electron transport chain at complex II. In previous studies in striatum-isolated nerve endings (synaptosomes), we found that vinpocetine decreased dopamine (DA) at expense of its main metabolite 3,4-dihydroxyphenylacetic acid (DOPAC), and that 3-NPA increased DA, reactive oxygen species (ROS), DA-quinone products formation, and decreased DOPAC. Therefore, in this study, the possible effect of vinpocetine on 3-NPA-induced increase in DA, ROS, lipid peroxidation, and DA-quinone products formation in striatum synaptosomes were investigated, and compared with the effects of the antioxidant ?-tocopherol. Results show that the increase in DA induced by 3-NPA was inhibited by both 25 ?M vinpocetine and 50 ?M ?-tocopherol. Vinpocetine, as ?-tocopherol, also inhibited 3-NPA-induced increase in ROS (as judged by DCF fluorescence), lipid peroxidation (as judged by TBA-RS formation), and DA-quinone products formation (as judged by the nitroblue tetrazolium reduction method). As in addition to the inhibition of complex II exerted by 3-NPA, 3-NPA increases DA-oxidation products that in turn can inhibit other sites of the respiratory chain, the drop in DA produced by vinpocetine and ?-tocopherol may importantly contribute to their protective action from oxidative damage, particularly in DA-rich structures. PMID:23121080

Herrera-Mundo, Nieves; Sitges, María

2013-01-01

282

D-amphetamine (A)-induced dopamine (DA) release is not strictly dependent on newly-synthesized transmitter  

SciTech Connect

A is thought to exert its stimulant effects by releasing DA from a newly synthesized transmitter pool. This hypothesis was evaluated directly by measuring the basal efflux and electrically-evoked release of endogenous DA and dihydroxyphenylacetic acid (DOPAC). In striatal slices from reserpine-treated rabbits A increased DA efflux, reduced DOPAC efflux, and inhibited electrically-evoked /sup 3/H-ACh release in a concentration-dependent manner. These effects could not be mimicked by inhibition of neuronal uptake or MAO, but were blocked by inhibition of DA synthesis or neuronal uptake, and were potentiated by inhibition of MAO. In slices with intact vesicular transmitter stores A induced DA efflux was 2-fold greater than that seen in slices having no vesicular stores. Inhibition of DA synthesis reduced A-induced DA efflux by 60%, but had little effect on the ability of A to inhibit /sup 3/H-ACh release. A also increased the electrical stimulation-evoked overflow of DA (an effect which was attenuated slightly by synthesis inhibition), and potently inhibited DOPAC overflow. These results suggest that: 1) A facilitates efflux of axoplasmic DA by an accelerated exchange diffusion mechanism. The releasable axoplasmic pool is derived from newly synthesized and vesicular transmitter pools; 2) postsynaptic indices of transmitter release may be misleading; and 3) A increases electrically-evoked DA release possibly by inhibiting neuronal uptake.

Parker, E.; Cubeddu, L.

1986-03-05

283

O Repertório de Habilidades Sociais de profissionais que atuam com vendas no setor comercial de tecnologia da informação e suas implicações na qualidade da prestação de serviços  

Microsoft Academic Search

As organizações estão buscando sempre mais oferecer produtos e serviços de qualidade, atendendo às exigências, necessidades e desejos dos clientes. O presente estudo teve como objetivo diagnosticar o potencial do método QFD (Desdobramento dda Função Qualidade), como ferramenta para o desenvolvimento da qualidade nas atividades logísticas de armazenagem e movimentação de produtos no Centro de Distribuição de uma rede varejista

Marcos Macri Olivera

284

Divulgamos a lista de associados pais/mes/responsveis, em virtude do processo eleitoral para escolha da nova diretoria da APP que ser aberto em breve. Qualquer  

E-print Network

. ALZELITE ZENAIR GONÃ?ALVES 22. ALZEMI MACHADO 23. AMARILDO OSVALDO FORTE 24. ANA CLAUDIA MARIANO DO. CARLA AMORIM DA SILVA PINTO 52. CARLA DANIELA DUTRA ALVES 53. CARLA IVONI TEIXEIRA DE SOUZA 54. CARLA. CLAUDIA LEAL DE SOUZA MARTINS 73. CLAUDIA VITORIA HASCKEL LOCH 74. CLAUDINE MARIA FLORES LAGO 75. CLAUDIO

Floeter, Sergio Ricardo

285

Myelin management by the 18.5–kDa and 21.5–kDa classic myelin basic protein isoforms  

PubMed Central

The classic myelin basic protein (MBP) splice isoforms range in nominal molecular mass from 14 to 21.5 kDa, and arise from the gene in the oligodendrocyte lineage (Golli) in maturing oligodendrocytes. The 18.5-kDa isoform that predominates in adult myelin adheres the cytosolic surfaces of oligodendrocyte membranes together, and forms a two-dimensional molecular sieve restricting protein diffusion into compact myelin. However, this protein has additional roles including cytoskeletal assembly and membrane extension, binding to SH3-domains, participation in Fyn-mediated signaling pathways, sequestration of phosphoinositides, and maintenance of calcium homeostasis. Of the diverse post-translational modifications of this isoform, phosphorylation is the most dynamic, and modulates 18.5-kDa MBP’s protein-membrane and protein-protein interactions, indicative of a rich repertoire of functions. In developing and mature myelin, phosphorylation can result in microdomain or even nuclear targeting of the protein, supporting the conclusion that 18.5-kDa MBP has significant roles beyond membrane adhesion. The full-length, early-developmental 21.5-kDa splice isoform is predominantly karyophilic due to a non-traditional P-Y nuclear localization signal, with effects such as promotion of oligodendrocyte proliferation. We discuss in vitro and recent in vivo evidence for multifunctionality of these classic basic proteins of myelin, and argue for a systematic evaluation of the temporal and spatial distributions of these protein isoforms, and their modified variants, during oligodendrocyte differentiation. PMID:23398367

Harauz, George; Boggs, Joan M.

2013-01-01

286

Characteristics of 26 kDa antigen of H. Pylori by Monoclonal Antibody.  

PubMed

Alkylhydroperoxide reductase (AhpC, the 26 kDa antigen) is one of the abundant antioxidant enzymes in Helicobacter pylori and seems to have a good potential for use in development of immunoassays to detect  H. pylori infection in clinical specimens. This study aimed to investigate some properties of this antigen by the produced monoclonal antibodies. Five established hybridoma cell lines secreting monoclonal antibodies (MAbs) against 26 kDa antigen of H. pylori were cultivated and MAbs were purified by affinity chromatography. Subsequently, MAbs were conjugated with biotin, and different combinations of capture and tracer antibodies used in sandwich ELISA. Immunoblotting of bacterial extracts were performed to estimate aggregation status of the antigen. Release of antigen from the cultivated bacteria on solid media was examined by sandwich ELISA, and also, existence of interference in fecal extract was investigated by immunoblotting and sandwich ELISA. Our findings showed that the MAbs against 26 kDa antigen of H. pylori could recognize three bands of nearly 25 kDa, 50 kDa, and 75 kDa in immunoblotting. This study also indicated presence of more antigens in the culture medium around the bacteria than the bacterial extract itself. The results of sandwich ELISA and immunoblotting on fecal extracts suggest the presence of interfering agents that prevent detection of antigen by antibody in ELISA but not in immunoblotting. In this study the oligomerization of the 26 kDa antigen, presence of interfering agents in stool matrix, and release of antigen to outside of bacteria, were demonstrated. PMID:25530147

Ghahremani, Hossein; Farshad, Shohreh; Amini Najafabadi, Hossein; Kashanian, Susan; Momeni Moghaddam, Mohammad Amin; Moradi, Nariman; Paknejad, Maliheh

2015-02-01

287

Católicos, fidelidade conjugal e AIDS: entre a cruz da doutrina moral e as espadas do cotidiano sexual dos adeptos1  

PubMed Central

Neste artigo discutimos a visão da Igreja Católica sobre sexualidade na interface com a epidemia do HIV/AIDS. Nossa reflexão está embasada em pesquisa etnográfica que envolveu dois meses de observação participante do cotidiano de católicos de um bairro popular da Região Metropolitana do Recife, além de contar com entrevistas a onze dos leigos engajados nos serviços religiosos da igreja do bairro e a oito sacerdotes que realizam seus trabalhos religiosos em outras localidades. Nelas abordamos diferentes temáticas relacionadas ao enfrentamento da epidemia da AIDS. Nesse contexto, conjugalidade e fidelidade se afiguram como importantes analisadores de como aqueles lidam com a epidemia, em uma variedade de re-descrições práticas e de re-interpretações conceptuais das assertivas do discurso moral religioso – ainda que, muitos impasses permaneçam em aberto em termos das prerrogativas da Igreja e seus possíveis rebatimentos na saúde sexual dos adeptos. PMID:21765650

Rios, Luis Felipe; de Aquino, Francisca Luciana; Muñoz-Laboy, Miguel; Oliveira, Cinthia; Parker, Richard

2009-01-01

288

Dinheiro pblico da sua conta www.portaldatransparencia.gov.br Unidade Auditada: FUNDACAO UNIVERSIDADE DE BRASILIA -FUB  

E-print Network

Dinheiro público é da sua conta www.portaldatransparencia.gov.br 1 Unidade Auditada: FUNDACAO, assim, em #12;Dinheiro público é da sua conta www.portaldatransparencia.gov.br 2 subsídio ao julgamento-se que a Instituição apresentou os conteúdos e formatos obrigatórios, nos termos da DN TCU nº 127

Maier, Rudolf Richard

289

2009 D.A. Menasc and Paul Ngo. All Rights Reserved. Daniel A. Menasc and Paul Ngo  

E-print Network

© 2009 D.A. Menascé and Paul Ngo. All Rights Reserved. 1 Daniel A. Menascé and Paul Ngo can be met when needed at the desired QoS level. © 2009 D.A. Menascé and Paul Ngo. All Rights Reserved in many cases. © 2009 D.A. Menascé and Paul Ngo. All Rights Reserved. 5 #12;· Pay as you go. · No need

Menascé, Daniel A.

290

Pressure Equilibrium and Jump Study on Unfolding of 23-kDa Protein from Spinach Photosystem II  

E-print Network

Pressure Equilibrium and Jump Study on Unfolding of 23-kDa Protein from Spinach Photosystem II Cui ABSTRACT Pressure-induced unfolding of 23-kDa protein from spinach photosystem II has been systematically is very sensitive to pressure. At 20°C and pH 5.5, 23-kDa protein shows a reversible two-state unfolding

Tian, Weidong

291

Metagonimus yokogawai: a 100-kDa somatic antigen commonly reacting with other trematodes.  

PubMed

This study was undertaken to characterize the properties of a 100 kDa somatic antigen from Metagonimus yokogawai. Monoclonal antibodies (mAbs) were produced against this 100 kDa antigen, and their immunoreactivity was assessed by western blot analysis with patients' sera. The mAbs against the 100 kDa antigen commonly reacted with various kinds of trematode antigens, including intestinal (Gymnophalloides seoi), lung (Paragonimus westermani), and liver flukes (Clonorchis sinensis and Fasciola hepatica). However, this mAb showed no cross-reactions with other helminth parasites, including nematodes and cestodes. To determine the topographic distribution of the 100 kDa antigen in worm sections, indirect immunoperoxidase staining was performed. A strong positive reaction was observed in the tegumental and subtegumental layers of adult M. yokogawai and C. sinensis. The results showed that the 100 kDa somatic protein of M. yokogawai is a common antigen which recognizes a target epitope present over the tegumental layer of different trematode species. PMID:24850966

Han, Eun-Taek; Yang, Hyun-Jong; Park, Young-Jin; Park, Jeong-Hyun; Chai, Jong-Yil

2014-04-01

292

Mycobacterium tuberculosis 38kDa antigen and its encoding gene-experience in diagnostic applications.  

PubMed

Our experience has revealed that the detection of 38 kDa antigen or antibody to the antigen in various fluids is useful in diagnosis of various mainfestations of tuberculosis. The PCR developed for 340bp sequence of its encoding gene also shows a high degree of sensitivity and specificity. Thus the 38 kDa antigen/antibody combination or the PCR are ideal for development of kits for diagnosis. These immunoassays to be successful, isolation of the 38 kDa antigen in large quantities is essential. Using recombinant DNA technology and expression inE. coli this has been achieved. However, such recombinant antigen does not have the same immunological properties as the native antigen and hence not suitable in immunodiagnosis. To fully realise the potential of the MoAb defined antigens such as the 38 kDa antigen, 19 kDa antigen and others it is essential to devise alternative vector-host systems that help in glycosylation, do not accumulate as inclusion bodies and can be isolated with less damage. PMID:23100905

Kadival, G V; D'souza, C D; Kameswaran, M; Samuel, A M

1997-12-01

293

Low strain, long life creep fatigue of AF2-1DA and INCO 718  

NASA Technical Reports Server (NTRS)

Two aircraft turbine disk alloys, GATORIZED AF2-DA and INCO 718 were evaluated for their low strain long life creep-fatigue behavior. Static (tensile and creep rupture) and cyclic properties of both alloys were characterized. The cntrolled strain LCF tests were conducted at 760 C (1400 F) and 649 C (1200 F) for AF2-1DA and INCO 718, respectively. Hold times were varied for tensile, compressive and tensile/compressive strain dwell (relaxation) tests. Stress (creep) hold behavior of AF2-1DA was also evaluated. Generally, INCO 718 exhibited more pronounced reduction in cyclic life due to hold than AF2-1DA. The percent reduction in life for both alloys for strain dwell tests was greater at low strain ranges (longer life regime). Changing hold time from 0 to 0.5, 2.0 and 15.0 min. resulted in corresponding reductions in life. The continuous cycle and cyclic/dwell initiation failure mechanism was predominantly transgranular for AF2-1DA and intergranular for INCO 718.

Thakker, A. B.; Cowles, B. A.

1983-01-01

294

Essential 170-kDa subunit for degradation of crystalline cellulose by Clostridium cellulovorans cellulase.  

PubMed Central

The cellulase complex from Clostridium cellulovorans has been purified and its subunit composition determined. The complex exhibits cellulase activity against crystalline cellulose as well as carboxymethylcellulase (CMCase) and cellobiohydrolase activities. Three major subunits are present with molecular masses of 170, 100, and 70 kDa. The 100-kDa subunit is the major CMCase, although at least four other, minor subunits show CMCase activity. The 170-kDa subunit has the highest affinity for cellulose, does not have detectable enzymatic activity, but is necessary for cellulase activity. Immunological studies indicate that the 170-kDa subunit is not required for binding of the catalytic subunits to cellulose and therefore does not function solely as an anchor protein. Thus this core subunit must have multiple functions. We propose a working hypothesis that the binding of the 170-kDa subunit converts the crystalline cellulose to a form that is capable of being hydrolyzed in a cooperative fashion by the associated catalytic subunits. Images PMID:2107547

Shoseyov, O; Doi, R H

1990-01-01

295

Fluorescence spectroscopy coupled with PARAFAC and PLS DA for characterization and classification of honey.  

PubMed

Fluorescence spectroscopy coupled with parallel factor analysis (PARAFAC) and Partial least squares Discriminant Analysis (PLS DA) were used for characterization and classification of honey. Excitation emission spectra were obtained for 95 honey samples of different botanical origin (acacia, sunflower, linden, meadow, and fake honey) by recording emission from 270 to 640nm with excitation in the range of 240-500nm. The number of fluorophores present in honey, excitation and emission spectra of each fluorophore, and their relative concentration are determined using a six-component PARAFAC model. Emissions from phenolic compounds and Maillard reaction products exhibited the largest difference among classes of honey of different botanical origin. The PLS DA classification model, constructed from PARAFAC model scores, detected fake honey samples with 100% sensitivity and specificity. Honey samples were also classified using PLS DA with errors of 0.5% for linden, 10% for acacia, and about 20% for both sunflower and meadow mix. PMID:25577082

Lenhardt, Lea; Bro, Rasmus; Zekovi?, Ivana; Drami?anin, Tatjana; Drami?anin, Miroslav D

2015-05-15

296

Effects of ?-Da1a a peptidic ?1A-adrenoceptor antagonist in human isolated prostatic adenoma and anaesthetized rats  

PubMed Central

Background and Purpose ?-Da1a, a 65 amino-acid peptide, has subnanomolar affinity and high selectivity for the human ?1A-adrenoceptor subtype. The purpose of this study was to characterize the pharmacological effects of ?-Da1a on prostatic function, both in vivo and in vitro. Experimental Approach ?-Da1a was tested as an antagonist of adrenaline-induced effects on COS cells transfected with the human ?1A-adrenoceptor as well as on human isolated prostatic adenoma obtained from patients suffering from benign prostatic hyperplasia. Moreover, we compared the effects of ?-Da1a and tamsulosin on phenylephrine (PHE)-induced increases in intra-urethral (IUP) and arterial pressures (AP) in anaesthetized rats, following i.v. or p.o. administration. Key Results On COS cells expressing human ?1A-adrenoceptors and on human prostatic strips, ?-Da1a inhibited adrenaline- and noradrenaline-induced effects. In anaesthetized rats, ?-Da1a and tamsulosin administered i.v. 30 min before PHE significantly antagonized the effects of PHE on IUP. The pKB values for tamsulosin and ?-Da1a for this effect were similar. With regards to AP, ?-Da1a only reduced the effect of PHE on AP at the lowest dose tested (10 ?g·kg?1), whereas tamsulosin significantly reduced PHE effects at doses between 10 and 150 ?g·kg?1. Conclusions and Implications ?-Da1a exhibited a relevant effect on IUP and a small effect on AP. In contrast, tamsulosin antagonized the effects of PHE on both IUP and AP. We conclude that ?-Da1a is more uroselective than tamsulosin. ?-Da1a is the most selective peptidic antagonist for ?1A-adenoceptors identified to date and could be a new treatment for various urological diseases. PMID:23005263

Palea, S; Maiga, A; Guilloteau, V; Rekik, M; Guérard, M; Rouget, C; Rischmann, P; Botto, H; Camparo, P; Lluel, P; Gilles, N

2013-01-01

297

Identification of an abundant 56 kDa protein implicated in food allergy as granule-bound starch synthase.  

PubMed

Rice, the staple food of south and east Asian counties, is considered to be hypoallergenic. However, several clinical studies have documented rice-induced allergy in sensitive patients. Rice proteins with molecular weights of 14-16, 26, 33, and 56 kDa have been identified as allergens. Recently, it was documented that the 56 kDa rice allergen was responsible for rice-induced anaphylaxis. The 14-16 kDa allergens have been identified as ?-amylase inhibitors; the 26 kDa protein has been identified as ?-globulin; and the 33 kDa protein has been identified as glyoxalase I. However, the identity of the 56 kDa rice allergen has not yet been determined. In this study, we demonstrate that serum from patients allergic to maize shows IgE binding to a 56 kDa protein that was present in both maize and rice but not in the oil seeds soybean and peanut. The 56 kDa IgE-binding protein was abundant in the rice endosperm. We have purified this protein from rice endosperm and demonstrated its reactivity to IgE antibodies from the serum of maize-allergic patients. The purified protein was subjected to matrix-assisted laser desorption ionization-time of flight-tandem mass spectrometry analysis, resulting in identification of this rice allergen as granule-bound starch synthase, a product of the Waxy gene. Immunoblot analysis using protein extracts from a waxy mutant of rice revealed the absence of the 56 kDa IgE-binding protein. Our results demonstrate that the 56 kDa rice allergen is granule-bound starch synthase and raise the possibility of using waxy mutants of rice as a potential source of the hypoallergenic diet for patients sensitized to the 56 kDa rice allergen. PMID:23675783

Krishnan, Hari B; Chen, Ming-Hsuan

2013-06-01

298

Pharmacokinetics of chlorogenic acid and corydaline in DA-9701, a new botanical gastroprokinetic agent, in rats.  

PubMed

1.Few studies describing the pharmacokinetic properties of chlorogenic acid (CA) and corydaline (CRD) which are marker compounds of a new prokinetic botanical agent, DA-9701, have been reported. The aim of the present study is to evaluate the pharmacokinetic properties CA and CRD following intravenous and oral administration of pure CA (1-8?mg/kg) or CRD (1.1-4.5?mg/kg) and their equivalent dose of DA-9701 to rats. 2.? Dose-proportional AUC and dose-independent clearance (10.3-12.1?ml/min/kg) of CA were observed following its administration. Oral administration of CA as DA-9701 did not influence the oral pharmacokinetic parameters of CA. Incomplete absorption of CA, its decomposition in the gastrointestinal tract, and/or pre-systemic metabolism resulted in extremely low oral bioavailability (F) of CA (0.478-0.899%). 3.? CRD showed greater dose-normalized AUC in the higher dose group than that in lower dose group(s) after its administration due to saturation of its metabolism via decreased non-renal clearance (by 51.3%) and first-pass extraction. As a result, the F of CRD following 4.5?mg/kg oral CRD (21.1%) was considerably greater than those of the lower dose groups (9.10 and 13.8%). However, oral administration of CRD as DA-9701 showed linear pharmacokinetics as a result of increased AUC and F in lower-dose groups (by 182% and 78.5%, respectively) compared to those of pure CRD. The greater oral AUC of CRD for DA-9701 than for pure CRD could be due to decreased hepatic and/or GI first-pass extraction of CRD by other components in DA-9701. PMID:24417753

Jung, Ji Won; Kim, Ju Myung; Jeong, Jin Seok; Son, Miwon; Lee, Hye Suk; Lee, Myung Gull; Kang, Hee Eun

2014-07-01

299

A importância da presença do farmacêutico na farmácia, na resolução de problemas básicos da saúde The importance of the pharmaceutist presence in the drugstore, in resolution of basic problems of health  

Microsoft Academic Search

SINOPSE Objetivo: Avaliar o efeito da presença do farmacêutico no estabelecimento, não só como cumprimento de uma lei federal, mas como forma de melhor orientar a população na busca da medicação com prescrição médica. Material e métodos: Foram visitadas 37 farmácias na cidade de Porto Alegre, RS, no primeiro semestre de 1999. Quatro acadêmicos de Medicina visitaram isoladamente cada uma

Geraldo Pereira Jotz

300

Clonorchis sinensis: Molecular Cloning and Characterization of 28-kDa Glutathione S-Transferase  

Microsoft Academic Search

Kang, S-Y., Ahn, I.-Y., Park, C-Y., Chung, Y-B., Hong, S.-T., Kong, Y., Cho, S-Y., and Hong, S-J. 2001. Clonorchis sinensis: Molecular cloning and characterization of 28-kDa glutathione S-transferase. Experimental Parasitology97, 186–195. A 28-kDa glutathione S-transferase (Cs28GST) was purified from a Clonorchis sinensis cytosolic fraction through anion-exchange and glutathione-affinity column chromatographies. A monoclonal antibody raised against Cs28GST reacted specifically to the

Shin-Yong Kang; Il-Young Ahn; Chi-Young Park; Young-Bae Chung; Sung-Tae Hong; Yoon Kong; Seung-Yull Cho; Sung-Jong Hong

2001-01-01

301

Solubilization of insoluble inorganic phosphate by Burkholderia cepacia DA23 isolated from cultivated soil  

PubMed Central

A mineral phosphate solubilizing bacterium, Burkholderia cepacia DA23 has been isolated from cultivated soils. Phosphate-solubilizing activities of the strain against three types of insoluble phosphate were quantitatively determined. When 3% of glucose concentration was used for carbon source, the strain had a marked mineral phosphate-solubilizing activity. Mineral phosphate solubilization was directly related to the pH drop by the strain. Analysis of the culture medium by high pressure liquid chromatography identified gluconic acid as the main organic acid released by Burkholderia cepacia DA23. Gluconic acid production was apparently the result of the glucose dehydrogenase activity and glucose dehydrogenase was affected by phosphate regulation. PMID:24031195

Song, Ok-Ryul; Lee, Seung-Jin; Lee, Yong-Seok; Lee, Sang-Cheol; Kim, Keun-Ki; Choi, Yong-Lark

2008-01-01

302

Detection and differentiation of 22kDa and 20kDa Growth Hormone proteoforms in human plasma by LC-MS/MS.  

PubMed

Human growth hormone (GH) is suspected to be widely and illegally used in sport to improve athletes' performance. For the detection of GH abuse, blood samples are screened for abnormal ratios between the 22 and 20kDa GH proteoforms that demonstrate the administration of the synthetic hormone. Current detection methods are based on classical immunoassays as they provide sufficient sensitivity for the detection of GH proteoforms. These antibody based methods, however, suffer from unclear selectivity and potential cross-reactivity towards similar proteins. For unambiguous GH detection, we report a Mass Spectrometry ImmunoAssay (MSIA) that first enriches GH from plasma with an antibody of relatively low specificity, and subsequently quantifies the 22 and 20kDa proteoforms by Selected Reaction Monitoring (SRM) LC-MS/MS analysis. This method proved superior to an antibody-free strategy based on GH purification by protein precipitation. Using GH-MSIA we successfully quantified the 22/20kDa GH ratio in post-exercise capillary plasma extracted from two individuals. This GH-MSIA is applicable to anti-doping and GH-related disease analysis. PMID:25556001

Such-Sanmartín, Gerard; Bache, Nicolai; Bosch, Jaume; Gutiérrez-Gallego, Ricardo; Segura, Jordi; Jensen, Ole N

2015-04-01

303

Racismo: o negro e as condições de sua inserção no mercado de trabalho brasileiro no final da década de 90  

Microsoft Academic Search

Resumo Este artigo tem por princípio contribuir criticamente para o debate em torno do racismo brasileiro, que se revela mais explicitamente no mercado de trabalho. Por meio de um pequeno diagnóstico, procurar-se-á confirmar a imensa dificuldade da luta em prol de uma legítima democracia, da igualdade de condições e oportunidades para a população negra, visto tamanha injustiça social, econômica e

Geruza de Fátima Tomé

304

O COMPOST... Oficina de Medioambiente (OMA-UDC). Vicerreitorado de Infraestruturas e Xestin Ambiental. Universidade da Corua  

E-print Network

O COMPOST... Oficina de Medioambiente (OMA-UDC). Vicerreitorado de Infraestruturas e Xestión Ambiental. Universidade da Coruña O COMPOST, A COMPOSTAXE E OS SOLOS Contidos: O COMPOST A MATERIA ORGÁNICA O COMPOSTEIRO A COMPOSTAXE BENEFICIOS DO COMPOST GUÍA DA COMPOSTAXE DOM�STICA O COMPOST A palabra

Fraguela, Basilio B.

305

32 CFR Appendix C to Part 623 - Agreement for Loan of US Army Materiel (DA Form 4881-R)  

Code of Federal Regulations, 2010 CFR

...true Agreement for Loan of US Army Materiel (DA Form 4881-R) C Appendix C to Part 623 National Defense Department...623—Agreement for Loan of US Army Materiel (DA Form 4881-R) EC24OC91.013 EC24OC91.014 EC24OC91.015...

2010-07-01

306

RESULTATS ET ENSEIGNEMENTS DU GROUPE DE TRAVAIL DE L'ESReDA SUR LES ENQUETES APRES ACCIDENTS  

E-print Network

RESULTATS ET ENSEIGNEMENTS DU GROUPE DE TRAVAIL DE L'ESReDA SUR LES ENQUETES APRES ACCIDENTS RESULTS AND LESSONS LEARNED FROM THE ESReDA'S ACCIDENT INVESTIGATION WORKING GROUP Nicolas DECHY Yves DIEN prévenir. L'enquête après accident ou post-événement est l'approche courante pour identifier les faits

Paris-Sud XI, Université de

307

X CONVEGNO ANNUALE CODAU 2012 Segreteria Codau c/o Politecnico di Milano Piazza Leonardo da Vinci, 32 20133 Milano  

E-print Network

X CONVEGNO ANNUALE CODAU 2012 Segreteria Codau c/o Politecnico di Milano Piazza Leonardo da #12; X CONVEGNO ANNUALE CODAU 2012 Segreteria Codau c/o Politecnico di Milano Piazza Leonardo da Vinci, 32 20133 Milano tel. 0223992001 fax 0223992225 email: segreteria@codau.it ­ www

Schettini, Raimondo

308

Human Resources Benefits Available to Retirees Fact Sheet October 2013 6030b2:da Faculty hired on or after September 1, 2001, and retired from the University  

E-print Network

Human Resources ­ Benefits Available to Retirees Fact Sheet October 2013 6030b2:da Faculty hired ­ Benefits Available to Retirees Fact Sheet October 2013 6030b2:da Faculty hired on or after September 1

309

Biofortification of soybean meal: immunological properties of the 27kDa gamma-zein  

Technology Transfer Automated Retrieval System (TEKTRAN)

Legumes, including soybeans (Glycine max), are deficient in sulfur-containing amino acids which are required for the optimal growth of monogastric animals. This deficiency can be overcome by expressing heterologous proteins rich in sulfur-containing amino acids in soybean seeds. A maize 27 kDa gam...

310

156 201 3 /2014 C A L E N DA R Peter Robinson  

E-print Network

Mystery and Suspense Writing 181 Mystery Writing Workshop 182 Writing Fantasy and Science Fiction 182 Fantasy and Science Fiction: Master Class 182 The Great Escape: Writing Fantasy 182 Writing Historical156 201 3 /2014 C A L E N DA R Peter Robinson Instructor, Mystery & Suspense Writing, Summer

Sokolowski, Marla

311

14 201 4 /2015 C A L E N DA R Student, Business & Professional Studies  

E-print Network

24 Internal Auditing 24 Management Accounting Fundamentals 25 Business Analysis 25 Business Analysis 26 Business Analysis for Financial Services 26 Business Management 26 Business Management14 201 4 /2015 C A L E N DA R Jane Lee Student, Business & Professional Studies "Taking classes

Sokolowski, Marla

312

14 201 3 /2014 C A L E N DA R Instructor, Business & Professional Studies  

E-print Network

Auditing 21 Management Accountant Fundamentals 22 Business Analysis 22 Business Analysis for Financial Accounting and Analysis 46 Management Accounting 46 Taxation for Canadian Business 47 The Budgeting Process14 201 3 /2014 C A L E N DA R James Jung Instructor, Business & Professional Studies "I love

Sokolowski, Marla

313

8 201 3 /2014 C A L E N DA R Gareth Lewis  

E-print Network

& Professional Studies · Accounting Levels 1, 2 and 3 · Advertising · Auditing (Internal) · Business Analysis · Business Analysis for Financial Services · Business English for International Professionals · Business 3 /2014 C A L E N DA R Certificates at the School of Continuing Studies Certificates in Business

Sokolowski, Marla

314

Efeitos do binarismo não resolvido na determinação da função de massa de aglomerados  

NASA Astrophysics Data System (ADS)

Através de simulações numéricas buscamos quantificar os efeitos que o binarismo não resolvido causa na determinação da função de massa (MF) de aglomerados estelares. Geramos diagramas cor-magnitude (CMDs) artificiais simulando uma população única, caracterizada por estrelas de mesma idade e composição quí mica, com uma fração de binárias não resolvidas e distribuição em massa das estrelas dada por uma MF do tipo lei de potência. A presença de pares de estrelas não resolvidos faz com que a MF obtida da função de luminosidade (LF) tenha a têndencia de ser mais plana do que a MF que gerou o CMD artificial. Propomos um tratamento de correção para tal efeito. Outro efeito relacionado diz respeito ao alargamento do CMD, que apresenta-se como um indicador do número total de estrelas no domí nio de baixas massas (m < 0.6M¤). Todos os resultados acima possuem uma forte dependência com os erros fotométricos e estão baseados na hipótese de que ambas estrelas do par não resolvido são sorteadas de uma mesma MF de forma independente. O objetivo final é aplicarmos o tratamento aqui desenvolvido para implementarmos a análise da nossa amostra de aglomerados ricos da Grande Nuvem de Magalhães.

Kerber, L. O.; Santiago, B. X.

2003-08-01

315

Determinação do extremo de baixa luminosidade da função de luminosidade através de simulações de Monte Carlo  

NASA Astrophysics Data System (ADS)

Neste trabalho apresentamos os principais resultados do estudo da população de galáxias anãs de baixo brilho superficial dos grupos compactos HCG44 e HCG68. A inclinação do extremo de baixa luminosidade a da função de luminosidade desses grupos foi estimado através de simulações de Monte Carlo. O método consistiu em simular galáxias anãs de baixo brilho superficial em imagens reais seguindo uma distribuição de magnitudes dada uma função de Schechter. Foram testados vários modelos com diferentes valores para os parâmetros M* e a da função de Schechter, e para cada um dos modelos foi repetido o mesmo processo de recuperação, seleção e análise usados com as galáxias anãs dos grupos. Os resultados de cada modelo foram então comparados com o observado nos grupos. Nossos resultados indicam que a distribuição de magnitudes (para magnitudes absolutas até MR»-12) observadas nos grupos são compatíveis com uma função de luminosidade de Schechter dada por um M* = -16 e um a entre -1.0 e -1.4, e portanto de acordo com a tendência observada de uma inclinação do extremo de baixa luminosidade da função de luminosidade de grupos mais plana (~1.2, Trentham & Tully 2002, MNRAS, 335, 712) que esperado pelo modelo hierárquico de formação de estruturas CDM (Cold Dark Matter - Matéria Escura Fria).

Campos, P. E.; Mendes de Oliveira, C.

2003-08-01

316

A Lagrangian model for spray behaviour within vine canopies Arthur Da Silva+  

E-print Network

for spray behaviour within vine canopies. Journal Aerosol Science, 2006 author-produced version of the final1 A Lagrangian model for spray behaviour within vine canopies Arthur Da Silva+ , Carole Sinfort.jaerosci.2005.05.016 hal-00451688,version1-29Jan2010 Author manuscript, published in "Journal of Aerosol Science

Boyer, Edmond

317

A Proof Markup Language for Semantic Web Paulo Pinheiro da Silva Deborah L. McGuinness  

E-print Network

A Proof Markup Language for Semantic Web Services Paulo Pinheiro da Silva Deborah L. Mc,dlm,fikes}@ksl.stanford.edu Abstract The Semantic Web is being designed to enable automated reasoners to be used as core components), an interlingua representation for justifications of results produced by Semantic Web ser- vices. We also

da Silva, Paulo Pinheiro

318

Stress and Failure Analysis of Rapidly Rotating Asteroid (29075) 1950 DA  

NASA Astrophysics Data System (ADS)

Rozitis et al. recently reported that near-Earth asteroid (29075) 1950 DA, whose bulk density ranges from 1.0 g cm–3 to 2.4 g cm–3, is a rubble pile and requires a cohesive strength of at least 44-76 Pa to keep from failing due to its fast spin period. Since their technique for giving failure conditions required the averaged stress over the whole volume, it discarded information about the asteroid's failure mode and internal stress condition. This paper develops a finite element model and revisits the stress and failure analysis of 1950 DA. For the modeling, we do not consider material hardening and softening. Under the assumption of an associated flow rule and uniform material distribution, we identify the deformation process of 1950 DA when its constant cohesion reaches the lowest value that keeps its current shape. The results show that to avoid structural failure the internal core requires a cohesive strength of at least 75-85 Pa. It suggests that for the failure mode of this body, the internal core first fails structurally, followed by the surface region. This implies that if cohesion is constant over the whole volume, the equatorial ridge of 1950 DA results from a material flow going outward along the equatorial plane in the internal core, but not from a landslide as has been hypothesized. This has additional implications for the likely density of the interior of the body.

Hirabayashi, Masatoshi; Scheeres, Daniel J.

2015-01-01

319

Using old Spam and Ham Samples to Train Email Filters Jose-Marcio Martins da Cruz  

E-print Network

Using old Spam and Ham Samples to Train Email Filters Jose-Marcio Martins da Cruz Centre de Calcul gvcormac@uwaterloo.ca ABSTRACT Email spam filters are commonly trained on a sample of recent spam and ham (non-spam) messages. We investigate the effect on filter performance of using samples of spam and ham

Cormack, Gordon V.

320

Francis Bacon e as marés: a concepção da natureza e o mecanicismo  

Microsoft Academic Search

Esta breve introdução visa duas tarefas ao mesmo tempo: primeiro, informar sobre a época provável de composição e o lugar ocupado, no conjunto da obra de Francis Bacon (1561-1626), pelo pequeno tratado intitulado De fluxu et refluxu maris (Do fluxo e refluxo do mar); segundo, expor a solução que nele se apresenta para o problema das marés, mostrando tratar-se de

Pablo Rubén Mariconda

2007-01-01

321

Michael Faraday e o manuscrito Matter: uma solução metafísica para o problema da ação a distância  

Microsoft Academic Search

O texto aqui traduzido, intitulado simplesmente Matéria, revela um Faraday muito pouco conhecido. É notório que Michael Faraday (1791-1867) fez grandes contribuições para a ciência do eletromagnetismo; dentre elas, duas merecem destaque: a descoberta ex- perimental da indução eletromagnética e a elaboração teórica do conceito de linhas de força, alternativa à explicação (de perspectiva newtoniana) baseada na ação a distân-

Sonia Maria Dion

2006-01-01

322

Vo1. nI. No. 1 CHARLES DA.RWI~  

E-print Network

Vo1. nI. No. 1 JUN 101930 JUNE 1930 ~. S-s 20 Cehts CHARLES DA.RWI~ #12;EVOLUTION e5\\ Journal of P'in at the recent dedit:tdion of Darwin's old hOllle, Down Housc, as a public nlOl1UllIent. E\\,OLUTIOl'; joins

323

As guerrilhas contra a cincia As chamadas Guerras da Cincia so, na verdade, guerrilhas  

E-print Network

foi um livro de Gross and Levitt, Higher Superstition-The Academic Left and Its Quarrels with Science2, Evelyn Fox Keller: Desenvolvimentos recentes na história e filosofia da ciência levaram à reavaliação que

Crato, Nuno

324

CONTENT MANAGMENT SYSTEMS ESTRATTO DA: Ileana D'Incecco, Progettare la comunicazione web per  

E-print Network

146 CONTENT MANAGMENT SYSTEMS ESTRATTO DA: Ileana D'Incecco, Progettare la comunicazione web per/08 #12;133 Content Management Systems Un CMS (Content Management System) è un sistema software che sull'uso combinato di database e linguaggi di programmazione lato server (come ASP, PHP o JSP) e

Goy, Anna

325

Purification and characterization of a 50 kDa glycoprotein in cercariae of Schistosoma mansoni  

E-print Network

Glycoproteins of S. mansoni were purified using concanavalin A affinity chromatography. A dominant 50 kDa glycoprotein (gp5O) was found to be unique to ConA-purified cercarial antigens (ConA-Cer), but absent in ConA-SEA or ConA-SWAP. Antigenicity...

Sun, Jianling

1994-01-01

326

Differentiation of Pueraria lobata and Pueraria thomsonii using partial least square discriminant analysis (PLS-DA).  

PubMed

The aims of the study were to differentiate Pueraria lobata from its related species Pueraria thomsonii and to examine the raw herbal material used in manufacturing kudzu root granules using partial least square discriminant analysis (PLS-DA). Sixty-four raw materials of P. lobata and P. thomsonii and kudzu root-labelled granules were analysed by ultra performance liquid chromatography. To differentiate P. lobata from P. thomsonii, PLS-DA models using the variables selected from the entire chromatograms, genetic algorithm (GA), successive projection algorithm (SPA), puerarin alone and six selected peaks were employed. The models constructed by GA and SPA demonstrated superior classification ability and lower model's complexity as compared to the model based on the entire chromatographic matrix, whilst the model constructed by the six selected peaks was comparable to the entire chromatographic model. The model established by puerarin alone showed inferior classification ability. In addition, the PLS-DA models constructed by the entire chromatographic matrix, GA, SPA and the six selected peaks showed that four brands out of seventeen granules were mislabelled as P. lobata. In conclusion, PLS-DA is a promising procedure for differentiating Pueraria species and determining raw material used in commercial products. PMID:23777642

Wong, Ka H; Razmovski-Naumovski, Valentina; Li, Kong M; Li, George Q; Chan, Kelvin

2013-10-01

327

Sociedade Brasileira de Qumica ( SBQ) Reunio Anual da Sociedade Brasileira de Qumica  

E-print Network

(PG), Antonio G. Ferreira 1 (PQ), Márcia M. C. Ferreira 2 (PQ), José F. F. Toledo 3 (PQ). 1 Barison, A.; Ferreira, A. G.; Toledo, J. F. F.; Ferreira, M.M.C. 27ª Reunião anual da Sociedade Brasileira

Ferreira, Márcia M. C.

328

Transparency of Vocational Qualifications: The Leonardo da Vinci Approach. CEDEFOP Panorama Series.  

ERIC Educational Resources Information Center

This report gives an overview of the situation of transparency of vocational qualifications by presenting measures introduced at the European Community level and by drawing attention to projects within the Leonardo da Vinci Program dealing with the issue. A 16-page executive summary appears first. Chapter 1 provides general background and aims.…

Bjornavold, Jens; Pettersson, Sten

329

Leonardo da Vinci, One Year on...a Different Look at Vocational Training in Europe.  

ERIC Educational Resources Information Center

Discusses the success of the Leonardo da Vinci program, a European laboratory of innovation in vocational training, a priority focus of investment in human resources and intelligence, and a way to mobilize innovative forces beyond national boundaries. Trends identified by the program focus on new information and communication technologies. (JOW)

Le Magazine, 1996

1996-01-01

330

Effects of Prolactin and Ergot Alkaloids on the Tubero-Infundibular Dopamine (DA) Neurons  

Microsoft Academic Search

Using the Falck-Hillarp fluorescence technique, the effect of various hypophyseal hormones on the rate of depletion of catecholamines (CA) from certain central neuron systems was investigated in the rat, after inhibition of CA synthesis. Prolactin, but not LH, FSH, ACTH, or vasopressin, caused a dose-dependent increase in the turnover of dopamine (DA) in nerve terminals of the external layer of

T. Hökfelt; K. Fuxe

1972-01-01

331

Rapid and efficient preparation of monoclonal antibodies against 35 kDa lipoprotein of Mycoplasma penetrans.  

PubMed

To develop a rapid and efficient method for preparing monoclonal antibodies (MAb) against 35 kDa lipoprotein of Mycoplasma penetrans, BALB/c mice were injected into the footpads for immunization, and the popliteal lymph nodes were isolated 19 days later for MAb-producing hybridomas, from which the mAbs against the 35 kDa lipoprotein were screened. The identification of the mAb against the 35 kDa lipoprotein was performed using indirect enzyme-linked immunosorbent assay (ELISA) and immunoblotting. Using popliteal lymph node procedures, we generated several positive clones, one of which we characterized by ELISA and immunoblot. The clone 1D41B8 was identified as the immunoglobulin G1 (IgG1) isotype, kappa chain with affinity constants (Ka) of 2.95 x 10(9) M(-1). The MAbs did not cross-react with a number of control bacteria, which included Mycoplasma fermentans, Mycoplasma hominis, and Mycoplasma genitalium. This is the first report on the preparation of mAbs against M. penetrans that is specific to 35 kDa lipoprotein using popliteal lymph nodes. The high-specificity and high-affinity MAbs produced by two methodologies used of hybridomas provide a basis for further research on the pathogenesis and early diagnosis of M. penetrans. This simple approach may become a method of choice for the generation and production of MAbs in a short period of time. PMID:17451357

Ferraz, Aline S; Belo, Elza F T; Coutinho, Ligia M C C; Oliveira, Ana P; De Gaspari, Elizabeth N

2007-04-01

332

Teorias do Capital Social e Desenvolvimento Local: lições a partir da experiência de Pintadas (Bahia, Brasil)  

Microsoft Academic Search

A literatura acadêmica e os relatórios de agências internacionais que tratam do tema do capital social partem, de modo quase generalizado, da constatação de que as variáveis econômicas não são suficientes para produzir desenvolvimento socialmente justo e ambientalmente sustentável. Afirmam que o crescimento econômico não produz, necessária e diretamente, o desenvolvimento social; relembram que as instituições e o sistema social

Carlos Milani

2005-01-01

333

Design, modeling and advanced control of the innovative parallel manipulator PaLiDA  

Microsoft Academic Search

The innovative parallel manipulator PaLiDA is the subject of this paper. Main aspects are treated from the design and concept of the drives to the advanced control concept of the complete system. A commercial direct linear drive is integrated into newly designed struts variable in length. The system's design and the strut's arrangement are carried out based on the optimization

Berend Denkena; Bodo Heimann; H. Adbellatif; Christian Holz

2005-01-01

334

Brain DA D2 Receptors Predict Reinforcing Effects of Stimulants in  

E-print Network

Brain DA D2 Receptors Predict Reinforcing Effects of Stimulants in Humans: Replication Study NORA D to the psychostimulant drug methylphenidate in nondrug-abusing subjects. Here, we assessed the replicability nondrug-abusing subjects to assess if they predicted the self-reports of "drug-liking" to intravenous

Homes, Christopher C.

335

Purification and some properties of the protein with 24 kDa in Tartary buckwheat  

Microsoft Academic Search

An allergic reaction to common buckwheat (Fagopyrumesculentumihas been reported from Europe and from Japan, and a 24 kDa globulin protein has been identified as one ofthe major allergens. In China, Tartary buckwheat (Fagopy­ rum tataricum) is consumed but there are few reports on buckwheat allergy. The aim of the present investigation was to purify a potential allergic protein from Tartary

Gunilla WIESLANDER; Dan NORBACK; Rufa LINI

336

A history of eye gaze tracking Abdallahi Ould Mohamed Matthieu Perreira Da Silva  

E-print Network

A history of eye gaze tracking Abdallahi Ould Mohamed Matthieu Perreira Da Silva Vincent Courboulay December 18, 2007 hal-00215967,version1-24Jan2008 #12;Abstract Applications that use eye and gaze have a his- torical review of eye tracker systems and applications. We address the use of gaze tracking

Paris-Sud XI, Université de

337

L'OCCULTAMENTO DELLE VIOLENZE SUI MINORI: IL CASO DELLA SINDROME DA ALIENAZIONE PARENTALE  

Microsoft Academic Search

In letteratura e nei tribunali italiani si sente parlare sempre più spesso della Sindrome da Alienazione Parentale (SAP) per spiegare il fatto che in taluni casi, dopo una separazione, la madre, solitamente il genitore affidata- rio, si opponga a mandare i figli in visita al padre arrivando a denunciarlo per abuso sessuale. Queste denunce sarebbero sempre false, anche quando i

MICAELA CRISMA; PATRIZIA ROMITO

338

Interdisciplinary/Collaborative Grant Eligible Expenses Revised: DA 02-16-12 Page 1  

E-print Network

Interdisciplinary/Collaborative Grant Eligible Expenses Revised: DA 02-16-12 Page 1 Office INTERDISCIPLINARY COLLABORATIVE RESEARCH GRANT Administration Policies ­ Eligibility of Expenses The following assistants and/or specialist/technical assistants. The Committee must be assured for the competence of any

Michelson, David G.

339

A Integracao de Ensino das Ciencias da Saude (An Integrated Medical Education Program [in Brazil]).  

ERIC Educational Resources Information Center

At the Sixth Annual Reunion of the Brazilian Association of Medical Schools (VI Reuniao Anual da Associacao Brasileira de Escolas Medicas) leaders in the Brazilian medical profession proposed an integrated educational program for training students in the fields of medicine and public health. Under Brazil's present system of education, all…

Pourchet-Campos, M. A.; Guimaraes Junior, Paulino

340

PLANEJAMENTO DA ROBOTIZAO DE UNIDADES ESTACIONRIAS DE PRODUO USANDO REALIDADE VIRTUAL  

E-print Network

PLANEJAMENTO DA ROBOTIZA��O DE UNIDADES ESTACIONÁRIAS DE PRODU��O USANDO REALIDADE VIRTUAL ISMAEL of reservoirs in ultra-deep water (400 feet or deeper), located in remote locations far from the coast, have in such scenarios. In this paper we present the use of virtual reality techniques in a virtual robotics simulator

Barbosa, Alberto

341

Rule Schemata for Game Artificial Intelligence Flavio S. Corr^ea da Silva1  

E-print Network

Rule Schemata for Game Artificial Intelligence Fl´avio S. Corr^ea da Silva1 and Wamberto W to specify inter- face standards for artificial intelligence tools and modules for games, as advocated Introduction Mutual cooperation and integration between Artificial Intelligence and Com- puter Games has been

Vasconcelos, Wamberto

342

A rigorous error analysis of D\\/A conversion with dynamic element matching  

Microsoft Academic Search

A known approach to reducing harmonic distortion in D\\/A converters involves a technique called dynamic element matching, The idea is not to reduce the power of the overall conversion error but rather to give it a random, noise-like structure. By reducing the correlation among successive samples of the conversion error, harmonic distortion is reduced. This paper presents the first rigorous

Ian Galton; Paolo Carbone

1995-01-01

343

Undergraduate Student Research Award Final Report Revised: DA 02-15-12 Page 1  

E-print Network

Undergraduate Student Research Award Final Report Revised: DA 02-15-12 Page 1 Office of Research Services Phone: (250) 807 9412 UBC Okanagan Campus UNDERGRADUATE STUDENT RESEARCH AWARD FINAL REPORT production, video, evidence of new media or visual art exhibition. #12;Undergraduate Student Research Award

Michelson, David G.

344

La verit`a matematica da Kant a Godel Alessandro Berarducci  

E-print Network

La verit`a matematica da Kant a G¨odel Alessandro Berarducci Pisa, 15 Marzo 2010 Questa `e la evidentemente essa non `e una scienza sperimentale? Kant 1787. L'intuizione Sentiamo cosa diceva un altro grande pensatore poco pi`u di un secolo prima. Immanuel Kant 1724-1804 "La rappresentazione dello spazio non pu

Berarducci, Alessandro

345

A digital quadrature modulator with on-chip d\\/a converter  

Microsoft Academic Search

A digital quadrature modulator is presented that can replace the fir st analog IF mixer stage of a base station transmitter. It interpolates orthogonal input carriers by 16 and performs digital quadrature modulation at car- rier frequencies , and . A 12-bit D\\/A- converter is integrated on-chip using a segmented current source architecture and a proper switching technique to reduce

Johan Sommarek; Jouko Vankka; Jaakko Ketola; Ilari Teikari; Kari Halonen

2003-01-01

346

Epitope mapping of a common 57 kDa antigen of Leishmania species by monoclonal antibodies.  

PubMed

BALB/c mice were immunized with freeze-thawed promastigote of Leishmania infantum. Five monoclonal antibodies (mAb) were selected, four IgM (designated as P1A9, P2G8, P5E3 and P6B3) and one IgG1 (P3D2). ELISA and Western blot analysis suggested that all monoclonal antibodies are specific to a band of 57 kDa antigen of L. infantum as well as other three Leishmania species (L. tropica, L. major and L. donovani). ELISA additivity tests revealed four epitopes on 57 kDa antigen as defined by four IgM monoclonal antibodies. Three distinct epitopes were recognized by P1A9, P2G8, and P6B3 antibodies and one epitope recognized by P5E3 antibody that shared with P2G8, and P6B3 epitopes. The 57 kDa protein was purified with affinity column and was shown to possess proteolytic activity. It seems that 57 kDa protein is the major surface Leishmania antigen (gp63) that has been used as subunit vaccine with appropriate adjuvant and induced protection against L. major infection in BALB/c mice. PMID:20615488

Nejad-Moghaddam, Amir; Abolhassani, Mohsen

2010-08-23

347

Long-term evolution of 1991 DA: A dynamically evolved extinct Halley-type comet  

NASA Technical Reports Server (NTRS)

The long-term dynamical evolution of 21 variational orbits for the intermediate-period asteroid 1991 DA was followed for up to +/-10(exp 5) years from the present. 1991 DA is close to the 2:7 resonance with Jupiter; it has avoided close encounters, within 1 AU, with this planet for at least the past 30,000 years, even at the node crossing. The future evolution typically shows no close encounters with Jupiter within at least 50,000 years. This corresponds to the mean time between node crossings with either Jupiter or Saturn. Close encounters with Saturn and Jupiter lead to a chaotic evolution for the whole ensemble, while secular perturbations cause large-amplitude swings in eccentricity and inclination (the latter covering the range 15 deg approximately less than i approximately less than 85 deg) which correlate with deep excursions of the perihelion distance to values much less than 1 AU. These variations are similar to those found in P/Machholz and a variety of other high-inclination orbits, e.g., P/Hartley-IRAS. We emphasize the connection between the orbital evolution of 1991 DA and that of Halley-type comets. If 1991 DA was once a comet, it is not surprising that it is now extinct.

Hahn, Gerhard; Bailey, M. E.

1992-01-01

348

Rendimento de palmito de pupunheira em função da aplicação de esterco bovino e adubação química  

Microsoft Academic Search

Palm heart yield in palm peach as a result of application of cattle manure and chemical fertilization The combination effect of cattle manure and mineral fertilization on palm heart yield in peach palm plants was evaluated. The experiment was conducted from April 2000 to May 2002 in Quartz Psamment at the Universidade Federal da Paraíba, in Areia, Brazil. The experiment

João T. Nascimento; Ademar P. de Oliveira; Adailson P. de Souza; Ivandro de F. da Silva; Adriana U. Alves

2005-01-01

349

La mosca di Hilbert. L'ultimo Teorema di Fermat da Fermat ai giorni nostri.  

E-print Network

`u tardi circa, ai tempi in cui per le strade di Tolosa passeggiava il giudice Pierre de Fermat (1601La mosca di Hilbert. L'ultimo Teorema di Fermat da Fermat ai giorni nostri. Una storia con molti continua. Il teorema di Fermat `e una mosca di Hilbert. (c) Un'altra mosca di Hilbert: gli integrali

Gatto, Letterio

350

Global prediction of dA and d2 O evaporation slopes for lakes  

E-print Network

Global prediction of dA and d2 H-d18 O evaporation slopes for lakes and soil water accounting slope of continental lakes and shallow soil water undergoing natural evaporation are predicted evaporation line slopes (4­5 range for lakes and 2­3 range for soil water) for South America, Africa

Edwards, Thomas W.D.

351

PHOTOSYSTEM 11-ASSOCIATED PROTEIN KINASE PHOSPHORYLATES A NOVEL 6.3 kDa PROTEIN WHICH  

E-print Network

PHOTOSYSTEM 11-ASSOCIATED PROTEIN KINASE PHOSPHORYLATES A NOVEL 6.3 kDa PROTEIN WHICH SUBSEQUENTLY Laboratory, Upton, NY 11973, USA. Key words: auxiliary enzymes, kinases, protein-protein interactions presence of multiple protein kinases in this system is mounting. Phosphorylation appears to be redox

Allen, John F.

352

O uso sustentable da auga e a sa relacin co territorio nos campus  

E-print Network

3.2. A evolución histórica 4.Obxectivos 5.Metodoloxía 5.1. Coñecemento dos fluxos únicas que ofrece a existencia de cursos fluviais, zonas húmidas e mananciais integración dos núcleos poboacionais orixinais da zona na propia dinámica dos campus

Fraguela, Basilio B.

353

Validation of the Delvotest SP NT DA. Performance Tested Method 011101.  

PubMed

Delvotest SP NT DA is designed to test milk for the presence of antibacterial substances, such as antibiotics. The test is made of an agar gel containing bacterial spores and a color indicator. The milk sample is added onto the agar gel, and the test is incubated at 64 degrees C. The principle of the test is based on the diffusion of possible inhibitory substances that may be present in the milk sample into agar. This reduces growth and acid production by the test organism, and delays or prevents the agar from changing color from purple to yellow. The Delvotest Accelerator is an automated system in which the plates containing the milk to be analyzed are placed for incubation. The Accelerator automatically detects the end of the incubation and reads the results. A sample containing antibiotic will be noted as "positive." A sample without antibiotics or with antibiotics at concentrations below detection level will be noted as "negative." The present report includes all technical details about the Delvotest SP NT DA, and the results of the validation study. The validation study demonstrates that the Delvotest SP NT DA conforms to the product performance claims and confirms the robustness of the test. The Delvotest SP NT DA is, therefore, granted Performance Tested Method certification. PMID:22468368

Hennart, Stephen L A; Faragher, John

2012-01-01

354

In response to Dr. Jose AP da Silva: fall prevention with vitamin D clarifications needed  

Technology Transfer Automated Retrieval System (TEKTRAN)

We agree with Dr. da Silva, and wish to clarify three issues raised by the recent IOM report concerning our 2009 meta-analysis on vitamin D and fall prevention. 1. The IOM questioned the inclusion of Broe et al., which did not pre-specify falls as a primary or secondary outcome. While this did viol...

355

A 16 kDa protein family overexpressed by Streptococcus thermophilus PB18 in acid environments.  

PubMed

The one- and two-dimensional protein patterns of Streptococcus thermophilus PB18 in the exponential and stationary phases of growth were analysed. One-dimensional SDS-PAGE showed that a 16 kDa protein was overexpressed in stationary phase as well as 2 h after an acid shock, and that it was not expressed when the bacteria reached the stationary phase in medium with limiting lactose concentrations (5 or 10 g l-1), in which the pH (5.5) was not as acid as in control cultures (pH 4.7, lactose 20 g l-1). The results support the idea that this protein is expressed in response to the acidic environment and not in response to the growth phase. Two-dimensional PAGE showed that nine proteins were expressed only during the exponential phase and ten others only during the stationary phase. The 16 kDa band seen in one-dimensional SDS-PAGE corresponded to a 16 kDa protein family observed on two-dimensional SDS-PAGE/IEF gels, whose expression was increased 8.5-fold when the extracellular pH reached a critical value below 5.0. The N-terminal sequences of proteins from two spots on the two-dimensional gels (members of the 16 kDa family) were determined and found to be identical. The physiological role of this protein family has not yet been elucidated. PMID:9168610

González-Márquez, H; Perrin, C; Bracquart, P; Guimont, C; Linden, G

1997-05-01

356

Environmental Regulation of a 25 kDa Dehydrin in Relation to Rhododendron Cold Acclimation  

Microsoft Academic Search

The influence of photoperiod and temperature on the seasonal (fall to winter) cold acclimation and accu- mulation of a 25 kDa dehydrin in Rhododendron 'Chionoides? was studied by exposing two groups of plants each in the greenhouse or outdoors to either a natural photoperiod (or short days) or an extended photoperiod (or long days) regime. Results suggest that the shortening

Calin O. Marian; Atilla Eris; Stephen L. Krebs; Rajeev Arora

2004-01-01

357

MATERNAL ATRAZINE (ATR) ALTERS HYPOTHALAMIC DOPAMINE (HYP-DA) AND SERUM PROLACTIN (SPRL) IN MALE PUPS  

EPA Science Inventory

Maternal Atrazine (ATR) alters hypothalamic dopamine (HYP-DA) and serum prolactin (sPRL) in male pups. 1Christopher Langdale, 2Tammy Stoker and 2Ralph Cooper. 1 Dept. of Cell Biology, North Carolina State University College of Veterinary Medicine, Raleigh, NC. 2 Endocrinology ...

358

Cutaneous Feedback of Planar Fingertip Deformation and Vibration on a da Vinci Surgical Robot  

E-print Network

. Visual feedback is already available in commercial robotic surgery systems (e.g., the Intuitive SurgicalCutaneous Feedback of Planar Fingertip Deformation and Vibration on a da Vinci Surgical RobotDept. of Advanced Robotics, Istituto Italiano di Tecnologia, Italy. 3Dept. of Mechanical Engineering

Siena, Università di

359

Improvements in Parallel Job Scheduling Using Gang Service Fabricio Alves Barbosa da Silva 1 \\Lambda  

E-print Network

Improvements in Parallel Job Scheduling Using Gang Service Fabricio Alves Barbosa da Silva 1 of California, Irvine CA 92697, U.S.A Abstract Gang scheduling has been widely used as a practical solution we propose a class of scheduling policies, dubbed Concurrent Gang, that is a generalization of gang

Scherson, Isaac D.

360

Bounds on Gang Service Scheduling Fabricio Alves Barbosa da Silva 1  

E-print Network

Bounds on Gang Service Scheduling Fabricio Alves Barbosa da Silva 1 Isaac D. Scherson 1;2 \\Lambda.S.A Abstract We define the bounds of two gang service algorithms, namely time balanced and instruction balanced balanced gang service is the best possible non­clairvoyant algorithm. When the objective is to increase

Scherson, Isaac D.

361

Specific binding of victorin to a 100-kDa protein from oats  

SciTech Connect

Susceptibility of oats to victoria blight, caused by the fungus Cochliobolus victoriae, and sensitivity to the host-specific toxin victorin, produced by the fungus, are controlled by the dominant allele at the Vb locus. It has been postulated that the Vb locus encodes a toxin receptor, although direct evidence for such a receptor is not available. Recent studies on structure-activity relationships of the toxin established a methodology for producing {sup 125}I-labeled victorin. Electrophoretic analysis of proteins from isogenic susceptible and resistant oat genotypes following treatment of leaves with radiolabeled victorin showed that victorin binds in a covalent and a genotype-specific manner to a 100-kDa protein only in susceptible oat leaf slices. This in vivo binding was competitively displaced by reduced victorin, a nontoxic protective compound, and appeared to be correlated with biological activity. In vitro binding to the 100-kDa protein in leaf extracts showed several differences from in vivo binding. Binding was not genotype specific and required a reducing agent that was not required for in vivo binding. Differential centrifugation showed that the 100-kDa victorin binding protein was not a cytosolic protein but was enriched in a high-speed particulate fraction. The data support the hypothesis that the 100-kDa protein is the victorin receptor.

Wolpert, T.J.; Macko, V. (Cornell Univ., Ithaca, NY (USA))

1989-06-01

362

PanDA Pilot Submission using Condor-G: Experience and Improvements  

E-print Network

PanDA is the workload management system of the ATLAS experiment, used to run production and user analysis jobs on the grid. As a late-binding, pilot-based system, the maintenance of a smooth and steady stream of pilot jobs to all grid sites is critical for PanDA operation. The ATLAS Computing Facility (ACF) at BNL, as the ATLAS Tier 1 center in the US, operates the pilot submission systems for the US. This is done using the PanDA "AutoPilot" scheduler component which submits pilot jobs via Condor-G, a grid job scheduling system developed at the University of Wisconsin-Madison. In this talk, we discuss the operation and performance of the Condor-G pilot submission at BNL, with emphasis on the challenges and issues encountered in the real grid production environment. With the close collaboration of Condor and PanDA teams, the scalability and stability of the overall system has been greatly improved over the last year. We review improvements made to Condor-G resulting from this collaboration, including isolation...

Zhao, Xin; The ATLAS collaboration; Wlodek, Tom; Wenaus, Torre; Frey, Jaime; Tannenbaum, Todd; Livny, Miron

2010-01-01

363

PanDA Pilot Submission using Condor-G: Experience and Improvements  

E-print Network

PanDA (Production and Distributed Analysis) is the workload management system of the ATLAS experiment, used to run managed production and user analysis jobs on the grid. As a late-binding, pilot-based system, the maintenance of a smooth and steady stream of pilot jobs to all grid sites is critical for PanDA operation. The ATLAS Computing Facility (ACF) at BNL, as the ATLAS Tier1 center in the US, operates the pilot submission systems for the US. This is done using the PanDA “AutoPilot” scheduler component which submits pilot jobs via Condor-G, a grid job scheduling system developed at the University of Wisconsin-Madison. In this paper, we discuss the operation and performance of the Condor-G pilot submission at BNL, with emphasis on the challenges and issues encountered in the real grid production environment. With the close collaboration of Condor and PanDA teams, the scalability and stability of the overall system has been greatly improved over the last year. We review improvements made to Condor-G resu...

Zhao, X; The ATLAS collaboration; Wlodek, T; Wenaus, T; Frey, J; Tannenbaum, T; Livny, M

2011-01-01

364

Next Generation PanDA Pilot for ATLAS and Other Experiments  

NASA Astrophysics Data System (ADS)

The Production and Distributed Analysis system (PanDA) has been in use in the ATLAS Experiment since 2005. It uses a sophisticated pilot system to execute submitted jobs on the worker nodes. While originally designed for ATLAS, the PanDA Pilot has recently been refactored to facilitate use outside of ATLAS. Experiments are now handled as plug-ins such that a new PanDA Pilot user only has to implement a set of prototyped methods in the plug-in classes, and provide a script that configures and runs the experiment-specific payload. We will give an overview of the Next Generation PanDA Pilot system and will present major features and recent improvements including live user payload debugging, data access via the Federated XRootD system, stage-out to alternative storage elements, support for the new ATLAS DDM system (Rucio), and an improved integration with glExec, as well as a description of the experiment-specific plug-in classes. The performance of the pilot system in processing LHC data on the OSG, LCG and Nordugrid infrastructures used by ATLAS will also be presented. We will describe plans for future development on the time scale of the next few years.

Nilsson, P.; Barreiro Megino, F.; Caballero Bejar, J.; De, K.; Hover, J.; Love, P.; Maeno, T.; Medrano Llamas, R.; Walker, R.; Wenaus, T.; Atlas Collaboration

2014-06-01

365

Correlation of fretting fatigue experimental results using an asymptotic approach D.A. Hills a  

E-print Network

Correlation of fretting fatigue experimental results using an asymptotic approach D.A. Hills a , A online 23 February 2012 Keywords: Fretting fatigue Incomplete contacts Asymptotic methods Short crack. They are then used to re-analyse several sets of publicly available fretting fatigue data. Several different

Barber, James R.

366

English languagE Program WinniPEg, manitoba, CanaDa  

E-print Network

English languagE Program WinniPEg, manitoba, CanaDa #12;thE univErsity of WinniPEg English language Intensive English, Canadian Work Experience, ESL Teacher Certificate, and Customized Programs. We are accredited by Languages Canada and are an authorized CanTEST (Canadian Test of English for Scholars

Martin, Jeff

367

2007 Peer Reviewed Archival Publications Adjeroh, D.A., U. Kandaswamy*  

E-print Network

community structure. International Journal of Computational Intelligence Research. 3(4). (LCSEE) Akladios. Texton-based segmentation of retinol vessels. Journal of Optical Society of America A (JOSA-A). 24(5): 1384-1393. (LCSEE) Adjeroh, D.A. and U. Kandaswamy* . 2007. Game-theoretic analysis of network

Mohaghegh, Shahab

368

ACCURACY AND RELIABILITY OF CEMS AT SUBPART DA (ELECTRIC UTILITIES) FACILITIES  

EPA Science Inventory

EPA promulgated minimum quality assurance (QA) requirements for Continuous Emission Monitoring Systems (CEMS) in 40 CFR Part 60 Appendix F. ppendix F requires Da source owners to develop site-specific QA plans and report the results of EPA specified QA activities each calendar qu...

369

A Utilização da Astronomia como Tema Interdisciplinar e Aplicações de Objetos de Aprendizagem  

NASA Astrophysics Data System (ADS)

Este trabalho visa analisar a possibilidade de relacionar conteúdos aplicados no ensino fundamental e médio de forma interdisciplinar por intermédio da astronomia, com a intervenção de objetos de aprendizagem que possam integrar as disciplinas e a utilização de recursos tecnológicos. Em uma pesquisa prévia com 20 professores de uma escola estadual situada na cidade de Guarulhos foi observado que apenas 25% dos professores utilizam algum recurso tecnológico para o desenvolvimento de conteúdos pertinentes à sua disciplina, tais como sites e softwares educativos, sendo que a maioria absoluta continua ensinando apenas com livros didáticos. A maior parte dos professores apresenta dificuldades em trabalhar sua disciplina de forma interdisciplinar, ou seja, 75% dos professores preferem aplicar os conteúdos seguindo uma hierarquia linear de tópicos, evitando a discussão de temas que de alguma forma estão relacionados. A astronomia pode vir à fascinar o ser humano e despertar sua curiosidade promovendo um maior interesse no aprendizado, podendo favorecer análises interdisciplinares de forma lógica e objetiva, desta forma colocar a astronomia como tema motivador interdisciplinar, pode ser relevante no que se refere ao distanciamento da fragmentação dos conteúdos. No Estado de São Paulo, a implantação da proposta curricular no ensino fundamental e médio mostra claramente a inserção da astronomia na maior parte das séries, principalmente na 6ª série em que todo o bimestre se fala de astronomia.

da Silva, L. A.; Voelzke, M. R.

2008-09-01

370

Tenure denied! not ready for promotion! no merit pay increase! poor Leonardo da Vinci!  

Microsoft Academic Search

Most academic institutions convey to faculty that they must have a clearly identified single or dual stream of research. Such a standard inhibits expertise. It stifles creativity and innovation and results in faculty unable to deal effectively with a broad range of doctoral students. People like Leonardo da Vinci, and other outstanding experts, fall outside of such a standard and,

Gary N. McLean

2007-01-01

371

From Sfumato to Transarchitectures and Osmose: Leonardo da Vinci's Virtual Reality  

Microsoft Academic Search

This paper explores the ways in which Leonardo da Vinci's anachronistic skepticism of Renaissance perspective and his subsequent invention of sfumato prefigure contemporary digital technology and its ability to literalize this formal technique. Marcos Novak and Char Davies offer parallel theories on the permeable boundaries among objects and between physical and virtual worlds. The resultant theories, like those of Leonardo,

Cami Nelson

2009-01-01

372

LEONARDO DA VINCI'S TENSILE STRENGTH TESTS: IMPLICATIONS FOR THE DISCOVERY OF ENGINEERING MECHANICS  

Microsoft Academic Search

In one of Leonardo Da Vinci's notebooks, an experiment is described where strengths in tension are measured for various lengths of wire. The notebook indicates that the results of these experiments were that longer wires were weaker than shorter wires. This result defies classical mechanics of materials. This conflict has been explained as a note-taking failure by Leonardo. This short

JAY R. LUND; JOSEPH P. BYRNE

2001-01-01

373

The proportion of the face in younger adults using the thumb rule of leonardo da vinci  

Microsoft Academic Search

The present study was conducted to examine whether the thumb rule of Leonardo da Vinci could be an objective method in the determination of the natural and artistic proportions of human face. In this study, a sample of 400 subjects (200 male and 200 female, 22–25 years old) was used. Measurements were made of the length of thumb, the length

Ö Oguz

1996-01-01

374

Leonardo da vinci, omo sanza lettere: A case of surface dysgraphia?  

Microsoft Academic Search

This paper is intended to analyse Leonardo da Vinci's orthography from a neuropsychological perspective. In his writings many errors are found which are never made by normal subjects as slips of the pen and are specific to a neuropsychological disorder known as surface dysgraphia. Evidence is also given in support of the hypothesis that Leonardo suffered from an analogous disorder

Giuseppe Sartori

1987-01-01

375

In situ photography of picosecond laser ablation of nickel D.A. Willis1  

E-print Network

reduces thermal damage to the surrounding area. In order to optimize a laser ablation process, and short pulse laser ablation is not well understood. Most ablation processes involve thermal transportIn situ photography of picosecond laser ablation of nickel D.A. Willis1 , X. Xu* School

Xu, Xianfan

376

11 CFR 111.15 - Motions to quash or modify a subpoena (2 U.S.C. 437d(a) (3), (4)).  

Code of Federal Regulations, 2013 CFR

...Motions to quash or modify a subpoena (2 U.S.C. 437d(a) (3), (4)). 111.15...GENERAL COMPLIANCE PROCEDURE (2 U.S.C. 437g, 437d(a)) Enforcement § 111...to quash or modify a subpoena (2 U.S.C. 437d(a) (3), (4))....

2013-01-01

377

11 CFR 111.12 - Subpoenas and subpoenas duces tecum; depositions (2 U.S.C. 437d(a) (3), (4)).  

Code of Federal Regulations, 2012 CFR

...subpoenas duces tecum; depositions (2 U.S.C. 437d(a) (3), (4)). 111.12...GENERAL COMPLIANCE PROCEDURE (2 U.S.C. 437g, 437d(a)) Enforcement § 111...subpoenas duces tecum; depositions (2 U.S.C. 437d(a) (3), (4))....

2012-01-01

378

11 CFR 111.13 - Service of subpoenas, orders and notifications (2 U.S.C. 437d(a) (3), (4)).  

Code of Federal Regulations, 2012 CFR

...subpoenas, orders and notifications (2 U.S.C. 437d(a) (3), (4)). 111.13...GENERAL COMPLIANCE PROCEDURE (2 U.S.C. 437g, 437d(a)) Enforcement § 111...subpoenas, orders and notifications (2 U.S.C. 437d(a) (3), (4))....

2012-01-01

379

11 CFR 111.13 - Service of subpoenas, orders and notifications (2 U.S.C. 437d(a) (3), (4)).  

Code of Federal Regulations, 2011 CFR

...subpoenas, orders and notifications (2 U.S.C. 437d(a) (3), (4)). 111.13...GENERAL COMPLIANCE PROCEDURE (2 U.S.C. 437g, 437d(a)) Enforcement § 111...subpoenas, orders and notifications (2 U.S.C. 437d(a) (3), (4))....

2011-01-01

380

11 CFR 111.12 - Subpoenas and subpoenas duces tecum; depositions (2 U.S.C. 437d(a) (3), (4)).  

Code of Federal Regulations, 2013 CFR

...subpoenas duces tecum; depositions (2 U.S.C. 437d(a) (3), (4)). 111.12...GENERAL COMPLIANCE PROCEDURE (2 U.S.C. 437g, 437d(a)) Enforcement § 111...subpoenas duces tecum; depositions (2 U.S.C. 437d(a) (3), (4))....

2013-01-01

381

11 CFR 111.13 - Service of subpoenas, orders and notifications (2 U.S.C. 437d(a) (3), (4)).  

Code of Federal Regulations, 2013 CFR

...subpoenas, orders and notifications (2 U.S.C. 437d(a) (3), (4)). 111.13...GENERAL COMPLIANCE PROCEDURE (2 U.S.C. 437g, 437d(a)) Enforcement § 111...subpoenas, orders and notifications (2 U.S.C. 437d(a) (3), (4))....

2013-01-01

382

11 CFR 111.12 - Subpoenas and subpoenas duces tecum; depositions (2 U.S.C. 437d(a) (3), (4)).  

Code of Federal Regulations, 2014 CFR

...subpoenas duces tecum; depositions (2 U.S.C. 437d(a) (3), (4)). 111.12...GENERAL COMPLIANCE PROCEDURE (2 U.S.C. 437g, 437d(a)) Enforcement § 111...subpoenas duces tecum; depositions (2 U.S.C. 437d(a) (3), (4))....

2014-01-01

383

11 CFR 111.15 - Motions to quash or modify a subpoena (2 U.S.C. 437d(a) (3), (4)).  

Code of Federal Regulations, 2014 CFR

...Motions to quash or modify a subpoena (2 U.S.C. 437d(a) (3), (4)). 111.15...GENERAL COMPLIANCE PROCEDURE (2 U.S.C. 437g, 437d(a)) Enforcement § 111...to quash or modify a subpoena (2 U.S.C. 437d(a) (3), (4))....

2014-01-01

384

11 CFR 111.12 - Subpoenas and subpoenas duces tecum; depositions (2 U.S.C. 437d(a) (3), (4)).  

Code of Federal Regulations, 2011 CFR

...subpoenas duces tecum; depositions (2 U.S.C. 437d(a) (3), (4)). 111.12...GENERAL COMPLIANCE PROCEDURE (2 U.S.C. 437g, 437d(a)) Enforcement § 111...subpoenas duces tecum; depositions (2 U.S.C. 437d(a) (3), (4))....

2011-01-01

385

11 CFR 111.15 - Motions to quash or modify a subpoena (2 U.S.C. 437d(a) (3), (4)).  

Code of Federal Regulations, 2012 CFR

...Motions to quash or modify a subpoena (2 U.S.C. 437d(a) (3), (4)). 111.15...GENERAL COMPLIANCE PROCEDURE (2 U.S.C. 437g, 437d(a)) Enforcement § 111...to quash or modify a subpoena (2 U.S.C. 437d(a) (3), (4))....

2012-01-01

386

11 CFR 111.13 - Service of subpoenas, orders and notifications (2 U.S.C. 437d(a) (3), (4)).  

Code of Federal Regulations, 2014 CFR

...subpoenas, orders and notifications (2 U.S.C. 437d(a) (3), (4)). 111.13...GENERAL COMPLIANCE PROCEDURE (2 U.S.C. 437g, 437d(a)) Enforcement § 111...subpoenas, orders and notifications (2 U.S.C. 437d(a) (3), (4))....

2014-01-01

387

11 CFR 111.15 - Motions to quash or modify a subpoena (2 U.S.C. 437d(a) (3), (4)).  

Code of Federal Regulations, 2011 CFR

...Motions to quash or modify a subpoena (2 U.S.C. 437d(a) (3), (4)). 111.15...GENERAL COMPLIANCE PROCEDURE (2 U.S.C. 437g, 437d(a)) Enforcement § 111...to quash or modify a subpoena (2 U.S.C. 437d(a) (3), (4))....

2011-01-01

388

The characterization of the dopaminergic profile of EMD 23,448, an indolyl-3-butylamine: Selective actions on presynaptic and supersensitive postsynaptic DA receptor populations  

Microsoft Academic Search

Summary The effects of the dopamine (DA) agonist EMD 23,448 on central normosensitive and supersensitive DA receptors were investigated. EMD 23,448 only slightly inhibits rat striatal DOPA synthesis in vivo and does not inhibit the enhanced striatal DOPA synthesis elicited by acute administration of haloperidol. Also unlike other DA agonists it does not increase striatal acetylcholine levels. However, it inhibits

M. Goldstein; K. Fuxe; E. Meller; C. A. Seyfried; L. Agnati; F. M. Mascagni

1987-01-01

389

Effects of acute amphetamine (AMPH) treatment on rat striatal dopamine (DA) receptor activity  

SciTech Connect

Upon administration of AMPH rats display a complex series of dose and time dependent behaviors and changes in dopaminergic activity. They found a decrease in D1 DA receptor-stimulated adenylate cyclase (DA-AC) activity in rat striatal membranes after acute in vivo AMPH at a dose and time of intense stereotyped behavior. The Ka for D1-AC activity increased and the Vmax decreased in striatal membranes from rats given 7.5 mg/kg AMPH i.p. and killed 1 hr later as compared to saline (SAL) controls. They examined whether the decrease of DA-AC was due to a change in receptor number or activation of GTP-binding protein, Ns. Female Holtzman rats were injected with SAL or 7.5 mg/kg AMPH and killed 1 hr later. A 27,000 x g striatal particulate fraction was prepared for AC assay or (/sup 3/H)DA binding with 10 nM spiroperidol. They found no difference in stimulation of AC by NaF, GTP or GppNHp at any dose tested in membranes from SAL- and AMPH-treated rats. Calmodulin-stimulated AC was also unchanged after AMPH. Specific binding at a saturating concentration of (/sup 3/H)DA was 191 +/- 31 and 117 +/- 14 fmol/mg prot in membranes from SAL- and AMPH-treated rats, respectively. This suggests an alteration is occurring at the level of the D1 receptor rather than at coupling of Ns with the AC catalytic subunit.

Roseboom, P.H.; Iwaniec, L.M.; Ackerman, J.M.; Gnegy, M.E.

1986-03-05

390

Deconstructing honeybee vitellogenin: novel 40 kDa fragment assigned to its N terminus  

PubMed Central

Vitellogenin, an egg-yolk protein precursor common to oviparous animals, is found abundantly in honeybee workers – a caste of helpers that do not usually lay eggs. Instead, honeybee vitellogenin (180 kDa) participates in processes other than reproduction: it influences hormone signaling, food-related behavior, immunity, stress resistance and longevity. The molecular basis of these functions is largely unknown. Here, we establish and compare the molecular properties of vitellogenin from honeybee hemolymph (blood) and abdominal fat body, two compartments that are linked to vitellogenin functions. Our results reveal a novel 40 kDa vitellogenin fragment in abdominal fat body tissue, the main site for vitellogenin synthesis and storage. Using MALDI-TOF combined with MS/MS mass-spectroscopy, we assign the 40 kDa fragment to the N terminus of vitellogenin, whereas a previously observed 150 kDa fragment corresponded to the remainder of the protein. We show that both protein units are N glycosylated and phosphorylated. Focusing on the novel 40 kDa fragment, we present a homology model based on the structure of lamprey lipovitellin that includes a conserved ?-barrel-like shape, with a lipophilic cavity in the interior and two insect-specific loops that have not been described before. Our data indicate that the honeybee fat body vitellogenin experiences cleavage unlike hemolymph vitellogenin, a pattern that can suggest a tissue-specific role. Our experiments advance the molecular understanding of vitellogenin, of which the multiple physiological and behavioral effects in honeybees are well established. PMID:21270306

Havukainen, Heli; Halskau, Øyvind; Skjaerven, Lars; Smedal, Bente; Amdam, Gro V.

2011-01-01

391

PanDA Pilot Submission using Condor-G: Experience and Improvements  

NASA Astrophysics Data System (ADS)

PanDA (Production and Distributed Analysis) is the workload management system of the ATLAS experiment, used to run managed production and user analysis jobs on the grid. As a late-binding, pilot-based system, the maintenance of a smooth and steady stream of pilot jobs to all grid sites is critical for PanDA operation. The ATLAS Computing Facility (ACF) at BNL, as the ATLAS Tier1 center in the US, operates the pilot submission systems for the US. This is done using the PanDA "AutoPilot" scheduler component which submits pilot jobs via Condor-G, a grid job scheduling system developed at the University of Wisconsin-Madison. In this paper, we discuss the operation and performance of the Condor-G pilot submission at BNL, with emphasis on the challenges and issues encountered in the real grid production environment. With the close collaboration of Condor and PanDA teams, the scalability and stability of the overall system has been greatly improved over the last year. We review improvements made to Condor-G resulting from this collaboration, including isolation of site-based issues by running a separate Gridmanager for each remote site, introduction of the 'Nonessential' job attribute to allow Condor to optimize its behavior for the specific character of pilot jobs, better understanding and handling of the Gridmonitor process, as well as better scheduling in the PanDA pilot scheduler component. We will also cover the monitoring of the health of the system.

Zhao, Xin; Hover, John; Wlodek, Tomasz; Wenaus, Torre; Frey, Jaime; Tannenbaum, Todd; Livny, Miron; ATLAS Collaboration

2011-12-01

392

Whole-genome sequences of DA and F344 rats with different susceptibilities to arthritis, autoimmunity, inflammation and cancer.  

PubMed

DA (D-blood group of Palm and Agouti, also known as Dark Agouti) and F344 (Fischer) are two inbred rat strains with differences in several phenotypes, including susceptibility to autoimmune disease models and inflammatory responses. While these strains have been extensively studied, little information is available about the DA and F344 genomes, as only the Brown Norway (BN) and spontaneously hypertensive rat strains have been sequenced to date. Here we report the sequencing of the DA and F344 genomes using next-generation Illumina paired-end read technology and the first de novo assembly of a rat genome. DA and F344 were sequenced with an average depth of 32-fold, covered 98.9% of the BN reference genome, and included 97.97% of known rat ESTs. New sequences could be assigned to 59 million positions with previously unknown data in the BN reference genome. Differences between DA, F344, and BN included 19 million positions in novel scaffolds, 4.09 million single nucleotide polymorphisms (SNPs) (including 1.37 million new SNPs), 458,224 short insertions and deletions, and 58,174 structural variants. Genetic differences between DA, F344, and BN, including high-impact SNPs and short insertions and deletions affecting >2500 genes, are likely to account for most of the phenotypic variation between these strains. The new DA and F344 genome sequencing data should facilitate gene discovery efforts in rat models of human disease. PMID:23695301

Guo, Xiaosen; Brenner, Max; Zhang, Xuemei; Laragione, Teresina; Tai, Shuaishuai; Li, Yanhong; Bu, Junjie; Yin, Ye; Shah, Anish A; Kwan, Kevin; Li, Yingrui; Jun, Wang; Gulko, Pércio S

2013-08-01

393

Dioscorea Extract (DA-9801) Modulates Markers of Peripheral Neuropathy in Type 2 Diabetic db/db Mice  

PubMed Central

The purpose of this study was to investigate the therapeutic effects of DA-9801, an optimized extract of Dioscorea species, on diabetic peripheral neuropathy in a type 2 diabetic animal model. In this study, db/db mice were treated with DA-9801 (30 and 100 mg/kg, daily, p.o.) for 12 weeks. DA-9801 reduced the blood glucose levels and increased the withdrawal latencies in hot plate tests. Moreover, it prevented nerve damage based on increased nerve conduction velocity and ultrastructural changes. Decrease of nerve growth factor (NGF) may have a detrimental effect on diabetic neuropathy. We previously reported NGF regulatory properties of the Dioscorea genus. In this study, DA-9801 induced NGF production in rat primary astrocytes. In addition, it increased NGF levels in the sciatic nerve and the plasma of type 2 diabetic animals. DA-9801 also increased neurite outgrowth and mRNA expression of Tieg1/Klf10, an NGF target gene, in PC12 cells. These results demonstrated the attenuation of diabetic peripheral neuropathy by oral treatment with DA-9801 via NGF regulation. DA-9801 is currently being evaluated in a phase II clinical study. PMID:25414776

Moon, Eunjung; Lee, Sung Ok; Kang, Tong Ho; Kim, Hye Ju; Choi, Sang Zin; Son, Mi-Won; Kim, Sun Yeou

2014-01-01

394

Dioscorea Extract (DA-9801) Modulates Markers of Peripheral Neuropathy in Type 2 Diabetic db/db Mice.  

PubMed

The purpose of this study was to investigate the therapeutic effects of DA-9801, an optimized extract of Dioscorea species, on diabetic peripheral neuropathy in a type 2 diabetic animal model. In this study, db/db mice were treated with DA-9801 (30 and 100 mg/kg, daily, p.o.) for 12 weeks. DA-9801 reduced the blood glucose levels and increased the withdrawal latencies in hot plate tests. Moreover, it prevented nerve damage based on increased nerve conduction velocity and ultrastructural changes. Decrease of nerve growth factor (NGF) may have a detrimental effect on diabetic neuropathy. We previously reported NGF regulatory properties of the Dioscorea genus. In this study, DA-9801 induced NGF production in rat primary astrocytes. In addition, it increased NGF levels in the sciatic nerve and the plasma of type 2 diabetic animals. DA-9801 also increased neurite outgrowth and mRNA expression of Tieg1/Klf10, an NGF target gene, in PC12 cells. These results demonstrated the attenuation of diabetic peripheral neuropathy by oral treatment with DA-9801 via NGF regulation. DA-9801 is currently being evaluated in a phase II clinical study. PMID:25414776

Moon, Eunjung; Lee, Sung Ok; Kang, Tong Ho; Kim, Hye Ju; Choi, Sang Zin; Son, Mi-Won; Kim, Sun Yeou

2014-09-01

395

Loss of 45 Da from a2 Ions and Preferential Loss of 48 Da from a2 Ions Containing Methionine in Peptide Ion Tandem Mass Spectra  

NASA Astrophysics Data System (ADS)

While analyzing tandem mass spectra of tryptic tripeptides, intense unassigned peaks were observed, corresponding to neutral loss of 45 Da from a2 ions. This process was confirmed by MS3 experiments. Based on exact mass analysis, the loss was ascribed to (NH3 + CO) or formamide. The proposed mechanism involves a cyclic form of the a2 ions. The structure of the a2 - 45 ions was confirmed by their fragmentation in MS3 experiments. Loss of (NH3 + CO) from the a2 ions occurs in competition with other paths, such as the loss of H2O or the formation of immonium ions. However, if the a2 ion contains methionine, a neutral loss of 48 Da (ascribed to CH3SH) predominates, and is followed by the loss of (NH3 + CO). These processes were confirmed by MS3 experiments. The intensity of the a2 - 48 peak formed from XaaMet has a maximum value of 42% (of the total intensity of all ions) for Xaa=Gly, varies between 15% and 40% for most other Xaa residues, is lower for residues that can undergo loss of water or ammonia, and is very low for Lys or Arg. When the order of the residues is reversed to MetXaa, the loss of 48 Da is much smaller. This effect can be used to determine the sequence of b2 ions containing Met in proteomic studies. Considerable loss of CH3SH is observed from doubly protonated tryptic tripeptides with N-terminal Met, but the loss is much less when they are singly protonated or when Met is in the center position.

Simón-Manso, Yamil; Neta, Pedatsur; Yang, Xiaoyu; Stein, Stephen E.

2011-02-01

396

Molecular cloning and expression analysis of the human DA41 gene and its mapping to chromosome 9q21.2–q21.3  

Microsoft Academic Search

DA41 was previously identified as one of the DAN-binding proteins, via a yeast-based two-hybrid screening strategy. In the\\u000a present study, we cloned a human homolog of DA41 cDNA. Structural analysis revealed that human DA41 cDNA consisted of 2,861 nucleotides in length and encoded a protein of 589 amino acids, with a predicted molecular mass of\\u000a 62.4 kDa. Human DA41 exhibited

Eiji Hanaoka; Toshinori Ozaki; Miki Ohira; Yohko Nakamura; Mikio Suzuki; Ei-ichi Takahashi; Hideshige Moriya; Akira Nakagawara; Shigeru Sakiyama

2000-01-01

397

First experience DaTSCAN imaging using cadmium-zinc-telluride gamma camera SPECT.  

PubMed

We report our first experience of brain DaTSCAN SPECT imaging using cadmium-zinc-telluride gamma camera (CZT-GC) in 2 cases: a 64-year-old patient suffering from essential tremor and a 73-year-old patient presenting with atypical bilateral extrapyramidal syndrome. In both cases, 2 different acquisitions were performed and compared, using a double-head Anger-GC, followed immediately by a second acquisition on CZT-GC. There were no significant visual differences between images generated by different GC. Our first result suggests that DaTSCAN SPECT is feasible on CZT-GC, allowing both injected dose and acquisition time reductions without compromising image quality. This experience needs to be evaluated in larger series. PMID:22785531

Farid, Karim; Queneau, Mathieu; Guernou, Mohamed; Lussato, David; Poullias, Xavier; Petras, Slavomir; Caillat-Vigneron, Nadine; Songy, Bernard

2012-08-01

398

Isolation and characterization of a 22 kDa protein with antifungal properties from maize seeds.  

PubMed

We have purified a 22 kDa protein from maize seeds to homogeneity by ammonium sulfate precipitation, chitin extraction and Mono-S column chromatography. The purified protein inhibited the growth of the agronomically important pathogens of potato wilt (Fusarium oxysporum) and tomato early blight (Alternaria solani). Sequence analysis of the purified protein showed that it has 52% homology with the sweet protein thaumatin (Edens, L., Hselinga, L., Klok, R., Ledeboer, A. M., Maat, J., Toonen, M. Y., Visser, C., and Verrips, C. (1982) Gene 18, 1-12), 57% homology with the pathogenesis-related protein (Cornelissen, B. J. C., Huijsduijnen, R. A. M., and Bol, J. F. (1986) Nature 321, 531-532) and 99% homology with the 22 kDa trypsin/alpha-amylase inhibitor (Richardson, M., Valdes-Rodriguez, S., and Blanco-Labra, A. (1987) Nature 327, 432-434). PMID:1731773

Huynh, Q K; Borgmeyer, J R; Zobel, J F

1992-01-15

399

Visual degradation in Leonardo da Vinci's iconic self-portrait: A nanoscale study  

NASA Astrophysics Data System (ADS)

The discoloration of ancient paper, due to the development of oxidized groups acting as chromophores in its chief component, cellulose, is responsible for severe visual degradation in ancient artifacts. By adopting a non-destructive approach based on the combination of optical reflectance measurements and time-dependent density functional theory ab-initio calculations, we describe and quantify the chromophores affecting Leonardo da Vinci's iconic self-portrait. Their relative concentrations are very similar to those measured in modern and ancient samples aged in humid environments. This analysis quantifies the present level of optical degradation of the Leonardo da Vinci's self-portrait which, compared with future measurements, will assess its degradation rate. This is a fundamental information in order to plan appropriate conservation strategies.

Conte, A. Mosca; Pulci, O.; Misiti, M. C.; Lojewska, J.; Teodonio, L.; Violante, C.; Missori, M.

2014-06-01

400

Iron abundance in the hot DA white dwarfs Feige 24 and G191 B2B  

NASA Technical Reports Server (NTRS)

Attention is given to model calculations of the far- and extreme-UV line spectra of highly ionized Fe species (Fe IV, Fe V, and Fe VI) for hot high-gravity H-rich stars. A spectral analysis of 31 hr of exposure of the DA white dwarf Feige 24 with IUE in the echelle mode reveals the presence of Fe with an abundance relative to H by number of (5-10) x 10 exp -6 with an uncertainty dominated by the determination of stellar parameters. An analysis of IUE data from the white dwarf G191 B2B results in a similar Fe abundance if this star shares similar atmospheric parameters (Teff, g) with Feige 24. Fe is thus the second most abundant photospheric element in hot DA white dwarfs.

Vennes, Stephane; Chayer, Pierre; Thorstensen, John R.; Bowyer, Stuart; Shipman, Harry L.

1992-01-01

401

Purification and characterization of a 24 kDa protein from tartary buckwheat seeds.  

PubMed

A 24 kDa protein was isolated from tartary buckwheat seeds by using chromatography of Superdex 75 gel filtration and Resource Q ion-exchange column. SDS-PAGE and Sephacryl S-200 gel filtration were used to provide information about the molecular mass of the protein purified from tartary buckwheat. The protein was composed of 215 amino acid residues and showed strong IgE binding activity in an ELISA test to the sera colleted from two patients allergic to buckwheat. These results suggested that the purified 24 kDa protein from tartary buckwheat seeds was an important functional protein and was relatively specific for buckwheat-allergic patients. It should be a very useful tool in the diagnosis of buckwheat allergy in the future. PMID:15277744

Wang, Zhuanhua; Zhang, Zheng; Zhao, Zhuohui; Wieslander, Gunilla; Norbäck, Dan; Kreft, Ivan

2004-07-01

402

A 9 kDa antifreeze protein from the Antarctic springtail, Gomphiocephalus hodgsoni.  

PubMed

A 9 kDA antifreeze protein (AFP) was isolated and purified from the Antarctic springtail, Gomphiocephalus hodgsoni. By combining selective sampling procedures and a modified ice affinity purification protocol it was possible to directly isolate a single AFP protein without recourse to chromatographic separation techniques. Mass spectrometry identified a single 9 kDa component in the purified ice fraction. Intramolecular disulphide bonding was suggested by the presence of 12 cysteine residues. The specific amino acid composition is unique, particularly with regard to the presence of histidine (11.5%). But it also shows noticeable commonalities with insect AFPs in the abundance of cysteine (13.8%), while simultaneously hinting, through the presence of glycine (11.5%), that the metabolic building blocks of AFPs in Collembola may have a phylogenetically-determined component. PMID:25025820

Hawes, T C; Marshall, C J; Wharton, D A

2014-08-01

403

[Repercussions of Maria da Penha law on addressing domestic violence in Porto Alegre].  

PubMed

The current paper sought to analyze the repercussions of Maria da Penha Law on addressing the issue of domestic violence against women in the city of Porto Alegre based on the view of professionals who constitute the care network for those women. Seven professionals, who work with the care for women who are victims of violence, were interviewed. Data suggests that the law has promoted changes in the field of violence prevention, assistance to women and punishment for the perpetrators, and it also increased the attention given to this phenomenon and enhanced female empowerment. It is concluded that the strengthening of the measures recommended by Maria da Penha Law still depends on investments in professional qualification, articulated actions between the places which provide assistance and the growing use of primary care services in order to improve the health of women and families exposed to violence. PMID:23405820

Alves, Elisângela da Silva; de Oliveira, Dora Lúcia Leidens Corrêa; Maffacciolli, Rosana

2012-09-01

404

Development of noSQL data storage for the ATLAS PanDA Monitoring System  

NASA Astrophysics Data System (ADS)

For several years the PanDA Workload Management System has been the basis for distributed production and analysis for the ATLAS experiment at the LHC. Since the start of data taking PanDA usage has ramped up steadily, typically exceeding 500k completed jobs/day by June 2011. The associated monitoring data volume has been rising as well, to levels that present a new set of challenges in the areas of database scalability and monitoring system performance and efficiency. These challenges are being met with a R&D effort aimed at implementing a scalable and efficient monitoring data storage based on a noSQL solution (Cassandra). We present our motivations for using this technology, as well as data design and the techniques used for efficient indexing of the data. We also discuss the hardware requirements as they were determined by testing with actual data and realistic loads.

Potekhin, M.; ATLAS Collaboration

2012-06-01

405

Development of noSQL data storage for the ATLAS PanDA Monitoring System  

E-print Network

For several years the PanDA Workload Management System has been the basis for distributed production and analysis for the ATLAS experiment at the LHC. Since the start of data taking PanDA usage has ramped up steadily, typically exceeding 500k completed jobs/day by June 2011. The associated monitoring data volume has been rising as well, to levels that present a new set of challenges in the areas of database scalability and monitoring system performance and efficiency. These challenges are being met with a R&D effort aimed at implementing a scalable and efficient monitoring data storage based on a noSQL solution (Cassandra). We present our motivations for using this technology, as well as data design and the techniques used for efficient indexing of the data. We also discuss the hardware requirements as they were determined by testing with actual data and realistic loads.

Potekhin, Maxim; The ATLAS collaboration

2011-01-01

406

Imugenicidade e segurança da vacina contra influenza A H1N1/2009 em pacientes com dermatomiosite juvenil.  

E-print Network

??Objetivos: Avaliar a imunogenicidade e segurança da vacina anti-influenza A/H1N1 2009 em pacientes com dermatomiosite juvenil (DMJ) comparados com controles saudáveis e a possível associação… (more)

Vanessa Ramos Guissa

2013-01-01

407

âCARACTERIZAÃÃO DA VULNERABILIDADE NATURAL DO AQÃÃFERO BOA VIAGEM NO MUNICÃPIO DO RECIFE â MÃTODO GOD.  

E-print Network

??Descrevem-se nesta dissertaÃÃo conceitos relacionados com a vulnerabilidade à poluiÃÃo de Ãguas subterrÃneas, bem como diversos mÃtodos clÃssicos e indexados, de avaliaÃÃo da vulnerabilidade natural… (more)

Eliseu Romero Campelo Correia

2006-01-01

408

ContribuiÃÃes ao estudo do eletrocardiograma e da pressÃo arterial em preguiÃas, Bradypus variegatus.  

E-print Network

??Os objetivos deste trabalho foram caracterizar o eletrocardiograma (ECG) e estabelecer o ritmo endÃgeno da pressÃo arterial (PA) em livre-curso, correlacionando-o à ocorrÃncia de comportamentos,… (more)

Eduardo MagalhÃes da Silva

2007-01-01

409

Anais da Academia Brasileira de Cincias (2002) 74(3): 463-476 (Annals of the Brazilian Academy of Sciences)  

E-print Network

Anais da Academia Brasileira de Ciências (2002) 74(3): 463-476 (Annals of the Brazilian Academy radially in a pinwheel fashion and in slabs of linear variation. The pinwheel arrangements have 800-1000 µm

Albright, Tom

410

Fast test method for serial A\\/D and D\\/A converters  

Microsoft Academic Search

An efficient test method for so-called serial analog\\/digital (A\\/D) and D\\/A converters which can be executed on digital automated test equipment is described. The method is applicable for stand-alone converters and for mixed-signal devices containing this type of converters. The proposed solution makes use of some special properties of serial converters. The method consists of a measurement of the output

A. Jongepier

1989-01-01

411

Measurement of the DA?NE luminosity with the KLOE detector using large angle Bhabha scattering  

Microsoft Academic Search

We describe the method of measuring the integrated luminosity of the e+e- collider DA?NE, the Frascati ?-factory. The measurement is done with the KLOE detector selecting large angle Bhabha scattering\\u000a events and normalizing them to the effective cross section. The e+e-?e+e-(?) cross section is calculated using different event generators which account for the \\u000a \\u000a radiative initial and final state corrections, and

F. Ambrosino; A. Antonelli; M. Antonelli; C. Bacci; P. Beltrame; G. Bencivenni; S. Bertolucci; C. Bini; C. Bloise; V. Bocci; F. Bossi; D. Bowring; P. Branchini; R. Caloi; P. Campana; G. Capon; T. Capussela; F. Ceradini; S. Chi; G. Chiefari; P. Ciambrone; S. Conetti; E. De Lucia; A. De Santis; P. De Simone; G. De Zorzi; S. Dell’Agnello; A. Denig; A. di Domenico; C. di Donato; S. Di Falco; B. Di Micco; A. Doria; M. Dreucci; G. Felici; A. Ferrari; M. L. Ferrer; G. Finocchiaro; S. Fiore; C. Forti; P. Franzini; C. Gatti; P. Gauzzi; S. Giovannella; E. Graziani; M. Incagli; W. Kluge; V. Kulikov; F. Lacava; G. Lanfranchi; J. Lee-Franzini; D. Leone; M. Martini; P. Massarotti; W. Mei; S. Miscetti; M. Moulson; S. Müller; F. Murtas; M. Napolitano; F. Nguyen; M. Palutan; E. Pasqualucci; A. Passeri; V. Patera; F. Perfetto; L. Pontecorvo; M. Primavera; P. Santangelo; E. Santovetti; G. Saracino; B. Sciascia; A. Sciubba; F. Scuri; I. Sfiligoi; T. Spadaro; M. Testa; L. Tortora; P. Valente; B. Valeriani; G. Venanzoni; S. Veneziano; A. Ventura; R. Versaci; G. Xu

2006-01-01

412

The Handedness of Leonardo da Vinci: A Tale of the Complexities of Lateralisation  

ERIC Educational Resources Information Center

The handedness of Leonardo da Vinci is controversial. Although there is little doubt that many of his well-attributed drawings were drawn with the left hand, the hatch marks of the shading going downwards from left to right, it is not clear that he was a natural left-hander, there being some suggestion that he may have become left-handed as the…

McManus, I. C.; Drury, Helena

2004-01-01

413

Novel 68 kDa autoantigen detected by rheumatoid arthritis specific antibodies  

Microsoft Academic Search

OBJECTIVE--To improve the understanding of the pathogenesis of rheumatoid arthritis (RA) by identifying novel, disease specific autoantibodies. METHODS--Total protein preparations from synovial membranes were separated electrophoretically and immunoblotted. Sera from RA patients were screened for predominant immunoreactions by blotting. A 68 kDa antigen target of the most predominant reaction was detected and further characterised. RESULTS--The dominant immunoreaction in most of

S Bläss; C Specker; H J Lakomek; E M Schneider; M Schwochau

1995-01-01

414

Genes influencing spinal bone mineral density in inbred F344, LEW, COP, and DA rats  

Microsoft Academic Search

Previously, we identified the regions of chromosomes 10q12–q31 and 15p16–q21 harbor quantitative trait loci (QTLs) for lumbar\\u000a volumetric bone mineral density (vBMD) in female F2 rats derived from Fischer 344 (F344) × Lewis (LEW) and Copenhagen 2331\\u000a (COP) × Dark Agouti (DA) crosses. The purpose of this study is to identify the candidate genes within these QTL regions contributing\\u000a to

Imranul Alam; Qiwei Sun; Daniel L. Koller; Lixiang Liu; Yunlong Liu; Howard J. Edenberg; Tatiana Foroud; Charles H. Turner

2010-01-01

415

Research of the orbital evolution of asteroid 2012 DA14 (in Russian)  

NASA Astrophysics Data System (ADS)

Research of the orbital evolution of asteroid 2012 DA14 on the time interval from 1800 to 2206 is made, an object close approaches with Earth and the Moon are detected, the probability of impact with Earth is calculated. The used mathematical model is consistent with the DE405, the integration was performed using a modified Everhart's method of 27th order, the probability of collision is calculated using the Monte Carlo method.

Zausaev, A. F.; Denisov, S. S.; Derevyanka, A. E.

416

Plasma pharmacological study on Da huang zhe chong capsule on platelet aggregation of normal person  

Microsoft Academic Search

Objective To develop a plasma pharmacological method evaluates the effect of Da Huang Zhe Chong capsule on platelet aggregation and\\u000a its mechanism, which is a representative Traditional Chinese Medicine Patent Prescription Promoting blood circulation by removing\\u000a blood stasis. Methods Platelets specimens from healthy volunteers made serum and plasma with medicine, while platelet PRP were separated, which\\u000a were divided into 8groups,

Dong-sheng Wang; Fang-ping Chen; Chang-jiang Xiao; Shi-lin He; Bin Fu; Xin Li; Xing-yu Cao; Yan Chen; Qin-zhi Xie

2005-01-01

417

Urodynamics in the anatomical work of Leonardo da Vinci (1452–1519)  

Microsoft Academic Search

Leonardo da Vinci (1452–1519) incorporates the symbiosis of art and medicine and can be adressed as the founder of medical\\u000a illustration in the time of the Renaissance. His anatomy studies were not published in his time, which explains why Leonardo's\\u000a outstanding knowledge of anatomy, physiology, and medicine had no impact on his scientific contemporaries and is therefore\\u000a primarily of retrospective

Dirk Schultheiss; Volker Grünewald; Udo Jonas

1999-01-01

418

Leonardo da Vinci on atherosclerosis and the function of the sinuses of Valsalva  

Microsoft Academic Search

lthough well studied by a medical scholar like Kenneth D. Keele, 1 Leonardo da Vinci’s elaborate study of the heart is not generally known. This article focuses on two of Leonardo’s achievements concerning atherosclerosis and the sinuses of Valsalva. 2 The first is his post-mortem observation on the degeneration of the vascular system in an old man, an early case

B. Boon

419

Mtodo e loucura da teorizao em psicanlise: a busca de figurabilidade  

E-print Network

própria construção teórica? Trata-se de dar conta da postura discursiva na teoria analítica, abordando, método, discurso psicanalítico, metáfora. 1 Thamy Ayouch é Psicanalista, Maître de Conférence (Professor Psicologia Clínica, com ênfase em Psicanálise, Fenomenologia, Teoria Política, Teoria do Gênero. Endereço

420

A performance study comparing manual and robotically assisted laparoscopic surgery using the da Vinci system  

Microsoft Academic Search

Background: The objective of this study was to compare the efficacy of the da Vinci robotic system using both the three-dimensional view (3D) and two-dimensional (2D) view options with traditional manually assisted laparoscopic techniques in performing standardized exercises. Methods: To evaluate surgical efficiency in the use of robotically assisted and manual laparoscopic surgery for standardized exercises six, last-year medical students

G. Hubens; H. Coveliers; L. Balliu; M. Ruppert; W. Vaneerdeweg

2003-01-01

421

Teoria da Homotopia Ficha 5 (A entregar ate 20/05/2006)  

E-print Network

definem uma teoria de homologia generalizada nos complexos celulares. Note que se E = S0 = {Sn }, EnTeoria da Homotopia Ficha 5 (A entregar at´e 20/05/2006) 1. (a) Hatcher 4.3.8 Mostre que p : E B; Z) se X ´e um complexo celular de dimens~ao n. (c) Hatcher 4.3.1 Mostre que [RP , CP ] ´e o grupo

Granja, Gustavo

422

As invenes portuguesas A Time distinguiu uma criao de investigadores da Universidade  

E-print Network

a morte súbita A invenção de Ana Teresa Freitas, 46 anos, não está na lista da revista norte-ameri- cana -um espessamento do músculo cardíaco que provoca morte súbita. Com o diagnóstico na mão, o médico, que

Instituto de Sistemas e Robotica

423

Leonardo da Vinci on atherosclerosis and the function of the sinuses of Valsalva  

Microsoft Academic Search

\\u000a Abstract  Although well studied by a medical scholar like Kenneth D. Keele, Leonardo da Vinci’s elaborate study of the heart is not\\u000a generally known. This article focuses on two of Leonardo’s achievements concerning atherosclerosis and the sinuses of Valsalva.\\u000a The first is his post-mortem observation on the degeneration of the vascular system in an old man, an early case history.

B. Boon

2009-01-01

424

The handedness of Leonardo da Vinci: A tale of the complexities of lateralisation  

Microsoft Academic Search

The handedness of Leonardo da Vinci is controversial. Although there is little doubt that many of his well-attributed drawings were drawn with the left hand, the hatch marks of the shading going downwards from left to right, it is not clear that he was a natural left-hander, there being some suggestion that he may have become left-handed as the result

I. C. McManus; Helena Drury

2004-01-01

425

On Ensino de Astronomia nas Cidades de Ribeirão Pires e Rio Grande da Serra  

NASA Astrophysics Data System (ADS)

Apesar da astronomia ser um dos temas indicados pelos Parâmetros Curriculares Nacionais, observa-se que poucas mudanças ocorreram desde a implementação do mesmo em sala de aula. A presente pesquisa diz respeito sobre como os tópicos de astronomia estão sendo abordados pelos professores no ensino médio. Optou-se por aplicar um questionário com os professores que ministram a disciplina de física. Os mesmos trabalham em escolas estaduais situadas nas cidades de Ribeirão Pires e Rio Grande da Serra, ambas subordinadas a Diretoria de Ensino de Mauá, no Estado de São Paulo. O questionário foi aplicado durante o 2° semestre de 2006. Até o momento os resultados são preliminares. Dos 82,0% dos professores que responderam ao questionário no município de Rio Grande da Serra, 66,7% não aplicaram nenhum tópico de astronomia, 77,8% não utilizaram qualquer tipo de programa computacional, 66,7% não utilizaram laboratório, que 77,8% nunca levaram os alunos a museus e ou planetários e que 66,7% não indicaram qualquer tipo de revista ou livro sobre astronomia aos seus alunos. No município de Ribeirão Pires, 53,3% dos professores responderam ao questionário, destes 75,0% não aplicaram nenhum tópico de astronomia, 93,8% não utilizaram qualquer tipo de programa computacional, 75,0% não utilizaram laboratório, 81,3% nunca levaram os alunos a museus e ou planetário e 56,3% não indicaram qualquer tipo de revista ou livro sobre astronomia ao seus alunos. Apesar da maioria dos professores reconhecerem que o conteúdo de astronomia influi na formação do jovem, os mesmos não incluem o tema em seus planejamentos escolares.

Faria, R. Z.; Voelzke, M. R.

2007-08-01

426

Fully digital controlled A.C. servo engraving machine based on DEC4DA  

NASA Astrophysics Data System (ADS)

A novel engraving machine (NUT-1A) is presented, in which fully digital controlled AC system based on DEC4DA was used to improve the machining precision and sensitivity. This engraving machine was constructed around AC servo motor with encoder, controlled by a servo motor control card - DEC4DA. As the upper unit of AC servo motor, DEC4DA was a numerical control generator, which received pulses form CPU by ISA bus, and these pulses were amplified and converted to drive AC servo actuator. This novel engraving machine can achieve a higher positioning accuracy of +/-0.01mm and positioning repetition of +/-0.005mm, and its resolution is 0.001mm/0.0001mm. Moreover, because of multi-closed loops were used in the system, the steady and transient performances are more excellent. This system ensures a much quicker current regulation in closed-loop operation, of acceleration and braking in both directions, as well as stable speed characteristics. Amplifier boards are protected against excessive current, excessive temperature and short circuiting of the motor supply cables.

Shu, Zhibing; Chen, Xianfeng; Zhang, Hairong; Huang, Yiqun; Yan, Caizhong

2005-12-01

427

Optimizing capillary electrophoresis for top-down proteomics of 30-80 kDa proteins.  

PubMed

The direct analysis of intact proteins via MS offers compelling advantages in comparison to alternative methods due to the direct and unambiguous identification and characterization of protein sequences it provides. The inability to efficiently analyze proteins in the "middle mass range," defined here as proteins from 30 to 80 kDa, in a robust fashion has limited the adoption of these "top-down" methods. Largely, a result of poor liquid chromatographic performance, the limitations in this mass range may be addressed by alternative separations that replace chromatography. Herein, the short migration times of CZE-ESI-MS/MS have been extended to size-sorted whole proteins in complex mixtures from Pseudomonas aeruginosa PA01. An electrokinetically pumped nanospray interface, a coated capillary, and a stacking method for on-column sample concentration were developed to achieve high-loading capacity and separation resolution. We achieved full width at half maximum of 8-16 s for model proteins up to 29 kDa and identified 30 proteins in the mass range of 30-80 kDa from P. aeruginosa PA01 whole cell lysate. These results suggest that CZE-ESI-MS/MS is capable of identifying proteins in the middle mass range in top-down proteomics. PMID:24596178

Li, Yihan; Compton, Philip D; Tran, John C; Ntai, Ioanna; Kelleher, Neil L

2014-05-01

428

N-linked sugar chain of 55-kDa royal jelly glycoprotein.  

PubMed

An N-linked sugar chain from 55-kDa royal jelly glycoprotein (RJGP), which maintains the high viability of rat liver primary cultured cell and is a different molecular species from 350-kDa RJGP [Kimura et al., Biosci. Biotech. Biochem., 59, 507-509 (1995)], has been identified. The sugar chains were released by hydrazinolysis followed by N-acetylation and pyridylamination. The structural analysis of the pyridylaminated sugar chain was done by a combination of sequential exo-mannosidase digestions, MALDI-TOF MS, and 500 MHz 1H-NMR. For the carbohydrate moiety of 55-kDa RJGP, only one N-linked sugar chain has been detected. The structure has been found to be Man alpha 1-->2Man alpha 1-->6(Man alpha 1--> 2Man alpha 1-->3)Man alpha 1-->6(Man alpha 1-->2Man alpha 1-->2Man alpha 1-->3)Man beta 1-->4GlcNAc beta 1-->4GlcNAc, which is a non-processed high mannose type structure. PMID:8988648

Kimura, Y; Kajiyama, S; Kanaeda, J; Izukawa, T; Yonekura, M

1996-12-01

429

Microscopic Observations on the Origin of Defects During Machining of Direct Aged (DA) Inconel 718 Superalloy  

NASA Astrophysics Data System (ADS)

Surface quality of advanced superalloys after machining is one of the major issues in the aerospace industry because it directly affects service characteristics of the machined part. Tool life of cemented carbide inserts with the TiAlN coating during machining of direct aged DA 718 alloys under roughing and finishing conditions has been under study. The defect origin on the surface of the machined part was investigated. Metallographic observations of the DA 718 were made using optical metallography and SEM/EDS. To find out the origins of surface defect formation, the morphology of machined parts and cross sections of the machined surfaces have been investigated. Two major categories of defects were detected on the surface of the machined part: cracks and tears. The origin of the cracks on the machined surface is related to shearing of the primary complex TiC/NbC carbide revealed in a structure of DA 718 alloy. At the same time, Nb-rich regions of the primary complex carbide interact with the environment (oxygen from air) during machining with further formation of low strength oxide layer on the surface, forming tears.

Dosbaeva, G. K.; Veldhuis, S. C.; Elfizy, A.; Fox-Rabinovich, G.; Wagg, T.

2010-11-01

430

Production of large transverse momentum dileptons and photons in $pp$, $dA$ and $AA$ collisions by photoproduction processes  

E-print Network

The production of large $P_{T}$ dileptons and photons originating from photoproduction processes in $pp$, $dA$ and $AA$ collisions is calculated. We find that the contribution of dileptons and photons produced by photoproduction processes is not prominent at RHIC energies. However, the numerical results indicate that the modification of photoproduction processes becomes evident in the large $P_{T}$ region for $pp$, $dA$ and $AA$ collisions at LHC energies.

Yong-Ping Fu; Yun-De Li

2011-11-29

431

Analise do Impacto da Rede Social na Marcac~ao de Fotos como Favoritas no Flickr1  

E-print Network

An´alise do Impacto da Rede Social na Marcac¸~ao de Fotos como Favoritas no Flickr1 Luiz Alves´udo compartilhado por um usu´ario ´e valorado ou disseminado pelos seus contatos na rede social [Bigonha et al. 2010´arios na rede social, procuramos identificar o impacto da rede de contatos na marcac¸~ao de conte´udos como

Cirne, Walfredo

432

Identification and purification of a novel 120-kDa protein that recognizes the cAMP-responsive element  

SciTech Connect

The TGACGTCA (CRE) motif required for function by a number of cellular (somatostatin, enkephalin, alpha-human chorionic gonadotropin) and viral (Ad5 E1A-inducible, HTLV-1 TAX-inducible) genes is the site of interaction of multiple sequence-specific complexes. A protocol has been developed for the fractionation and purification of these activities. We report here the purification from HeLa nuclear extracts of a novel 120-kDa polypeptide which by Southwestern blots, gel retardation, and UV cross-linking assays displays CRE-specific binding. The CRE-affinity purified 120-kDa protein displays properties distinct from those of the 43-kDa CREB/ATF polypeptide. The 120-kDa protein is readily phosphorylated in vitro by protein kinase C but not by protein kinase A, suggesting that this molecule may mediate cellular signals distinct from the cAMP-responsive pathway. In vitro transcription-complementation assays utilizing the purified 120-kDa protein failed to transactivate the cAMP-responsive somatostatin promoter suggesting that the mode of action of this 120-kDa polypeptide may require an activation step distinct from the cAMP-signaling pathway.

Andrisani, O.; Dixon, J.E. (Purdue Univ., West Lafayette, IN (USA))

1990-02-25

433

Projeto educação em ciências com observatórios virtuais: a participação da Escola Moppe no período 2000-2003  

NASA Astrophysics Data System (ADS)

O projeto Educação em Ciências com Observatórios Virtuais foi concebido pelo Instituto Astronômico e Geofísico da USP, agregando diversas instituições de ensino e pesquisa no país para desenvolver competências diversas na educação fundamental, média e superior utilizando a astronomia como ferramenta multidisciplinar. Este trabalho descreve a participação da MOPPE, escola-piloto do INPE no projeto, no período de 2000-2003. Serão apresentadas 1) a criação de um clube de ciências (1999 a 2001) cujo tema foi a colonização de Marte e 2) a ementa de astronomia trabalhada com as 7a. e 8a. séries do ensino fundamental. A proposta do projeto Colonizando Marte foi estudar diversos aspectos de uma missão interplanetária e construir experiementos que permitissem quantificar esses aspectos. Os resultados obtidos incluiram apresentações nas SBPC Jovem em 2000 e 2001. Discutiremos também as ementas de astronomia trabalhadas desde 2001 e o envolvimento dos alunos com atividades ligadas a astronomia, fora da aula de ciências. A inclusão de astronomia no currículo das últimas séries motivou a participação de mais alunos culminando com a conquista de duas medalhas para alunos da 7a. série na Olimpiada Brasileira de Astronomia em 2002. Houve também um aumento no número de participantes na OBA 2003 e nos projetos de astronomia mais elaborados nas Feira de Ciências de 2001 e 2002. Destacamos em 2003 a inclusão da MOPPE no projeto TIE - Telescopes in Education - da NASA, que utiliza o telescópio do Observatório de Mount Wilson (EUA) para observações remotas em projetos pedagógicos para o ensino de astronomia.

Wuensche, C. A.; Gavioli, E.; Oliveira, A. L. P. R. S.; da Silva, C.; Cardoso, H. P.; Estácio, S.

2003-08-01

434

AN IMPROVED SPECTROSCOPIC ANALYSIS OF DA WHITE DWARFS FROM THE SLOAN DIGITAL SKY SURVEY DATA RELEASE 4  

SciTech Connect

We present an improved spectroscopic and photometric analysis of hydrogen-line DA white dwarfs from the Sloan Digital Sky Survey Data Release 4 (SDSS DR4) based on model atmospheres that include improved Stark broadening profiles with non-ideal gas effects. We also perform a careful visual inspection of all spectroscopic fits with high signal-to-noise ratios (S/Ns > 12) and present improved atmospheric parameters (T{sub eff} and log g) for each white dwarf. Through a comparison of spectroscopic and photometric temperatures, we report the discovery of 35 DA+DB/DC double degenerate candidates and two helium-rich DA stars. We also determine that a cutoff at S/N = 15 optimizes the size and quality of the sample for computing the mean mass of DA white dwarfs, for which we report a value of 0.613 M{sub sun}. We compare our results to previous analyses of the SDSS DR4 and find a good agreement if we account for the shift produced by the improved Stark profiles. Finally, the properties of DA white dwarfs in the SDSS are weighed against those of the Villanova White Dwarf Catalog sample of Gianninas et al. We find systematically lower masses (by about 3% on average), a difference that we trace back to the data reduction procedure of the SDSS. We conclude that a better understanding of these differences will be important to determine the absolute temperature scale and mean mass of DA white dwarfs.

Tremblay, P.-E.; Bergeron, P.; Gianninas, A., E-mail: tremblay@astro.umontreal.ca, E-mail: bergeron@astro.umontreal.ca, E-mail: gianninas@astro.umontreal.ca [Departement de Physique, Universite de Montreal, C.P. 6128, Succ. Centre-Ville, Montreal, Quebec H3C 3J7 (Canada)

2011-04-01

435

The Greek Database of Seismogenic Sources (GreDaSS): the new version.  

NASA Astrophysics Data System (ADS)

The Greek Database of Seismogenic Sources (GreDaSS) is a repository of geological, tectonic and active fault data for the Greek territory and its surroundings including sectors of western Anatolia, southern Bulgaria, FYR of Macedonia and Albania. The principal aim of this international project is to create a homogenized framework of all data relevant to the seismotectonics, and especially the seismic hazard assessment, of Greece and its surroundings as well as a common research platform for performing seismic hazard analyses, modelling and scenarios from specific seismogenic structures. GreDaSS represents an on-going project based on the results of decades of investigations by the GreDaSS Working Group* and by numerous other researchers working on the active tectonics of the broader Aegean Region. Members of the WG have contributed in several national and European projects like FAUST (Faults as a seismological tool, 1998-2000) and SHARE (Seismic Hazard and Armonization in Europe, 2009-2012). The database is continuously updated by the WG, with the aim of improving its completeness in terms of seismogenic sources analysed and included, but also of enriching and better defining all parametric and ancillary information on each source. Preliminary and partial versions of GreDaSS have been already presented at previous congresses (Pavlides et al., 2010; Caputo et al., 2012; Sboras et al., 2013), but at next EGU the whole area and the most recent version of the database will be displayed. *) the principal scientific contributors belonging to the GreDaSS WG are: Sboras. S., Chatzipetros A., Koukouvelas I., Michailidou A., Valkaniotis S., Tarabusi G. Caputo R., Chatzipetros A., Pavlides S. and Sboras S. (2012): Ann. Geophysics, 55(5), 859-894, doi: 10.4401/ag-5168 Pavlides S., Caputo R., Sboras S., Chatzipetros A., Papathanasiou G. & Valkaniotis S. (2010): Bull. Geol. Soc. Greece, 43(1), 486-494 Sboras S., Pavlides S., Caputo R., Chatzipetros A., Michailidou A., Valkaniotis S. and Papathanasiou G. (2013): Boll. Geofis. Teor. Appl., 13 pp. doi: 10.4430/bgta0101.

Caputo, Riccardo; Pavlides, Spyros; GreDaSS Working Group

2014-05-01

436

ACTIVATION OF ALPHA1-ADRENOCEPTORS ENHANCES GLUTAMATE RELEASE ONTO VTA DA CELLS  

PubMed Central

The ventral tegmental area (VTA) plays an important role in reward and motivational processes that facilitate the development of drug addiction. Glutamatergic inputs into the VTA contribute to dopamine (DA) neuronal activation related to reward and response-initiating effects in drug abuse. Previous investigations indicate that alpha1-adrenoreceptors (?1-AR) are primarily localized at presynaptic elements in the ventral midbrain. Studies from several brain regions have shown that presynaptic ?1-AR activation enhance glutamate release. Therefore, we hypothesized that glutamate released onto VTA-DA neurons is modulated by pre-synaptic ?1-AR. Recordings were obtained from putative VTA-DA cells of male Sprague-Dawley rats (28–50 days postnatal) using voltage clamp techniques. Phenylephrine (10 µM) and methoxamine (80 µM), both ?1-AR agonists, increased AMPA receptor-mediated excitatory postsynaptic currents (EPSCs) amplitude evoked by electrical stimulation of afferent fibers (p<0.05). This effect was blocked by the ?1-AR antagonist prazosin (1 µM). Phenylephrine decreased the paired-pulse ratio and increased spontaneous EPSCs frequencies but not their amplitudes suggesting a presynaptic locus of action. No changes in miniature EPSCs (0.5 µM TTX) were observed after phenylephrine’s application which suggest that ?1-AR effect was action potential dependent. Normal extra- and intracellular Ca2+ concentration seems necessary for the ?1-AR effect since phenylephrine in low Ca2+ ACSF and depletion of intracellular Ca2+ stores with thapsigargin (10 µM) failed to increase the AMPA EPSCs amplitude . Chelerythrine (1 µM, PKC inhibitor) but not Rp-cAMPS (11 µM, PKA inhibitor) blocked the ?1-AR activation effect on AMPA EPSCs, indicating that a PKC intracellular pathway is required. These results demonstrated that presynaptic ?1-ARs activation modulates glutamatergic inputs that affect VTA-DA neurons excitability. ?1-ARs action might be heterosynaptically localized at glutamatergic fibers terminating onto VTA-DA neurons. It is suggested that drug-induced changes in ?1-AR could be part to the neuroadaptations occurring in the mesocorticolimbic circuitry during the addiction process. PMID:22542873

Velásquez-Martinez, M.C.; Vázquez-Torres, R.; Jiménez-Rivera, C.A.

2013-01-01

437

Heparin Binds 8 kDa Gelsolin Cross-?-Sheet Oligomers and Accelerates Amyloidogenesis by Hastening Fibril Extension†  

PubMed Central

Glycosaminoglycans (GAGs) are highly sulfated linear polysaccharides prevalent in the extracellular matrix, and they associate with virtually all amyloid deposits in vivo. GAGs accelerate the aggregation of many amyloidogenic peptides in vitro, but little mechanistic evidence is available to explain why. Herein, spectroscopic methods demonstrate that GAGs do not affect the secondary structure of the monomeric 8 kDa amyloidogenic fragment of human plasma gelsolin. Moreover, monomerized 8 kDa gelsolin does not bind to heparin under physiological conditions. In contrast, 8 kDa gelsolin cross-?-sheet oligomers and amyloid fibrils bind strongly to heparin, apparently due to electrostatic interactions between the negatively charged polysaccharide and a positively charged region of the 8 kDa gelsolin assemblies. Our observations are consistent with a scaffolding mechanism, whereby cross-?-sheet oligomers, upon formation, bind to GAGs, accelerating the fibril extension phase of amyloidogenesis, possibly by concentrating and orienting the oligomers to more efficiently form amyloid fibrils. Notably, heparin decreases the 8 kDa gelsolin concentration necessary for amyloid fibril formation, likely a consequence of fibril stabilization through heparin binding. Since GAG overexpression, which is common in amyloidosis, may represent a strategy to minimize cross-?-sheet oligomer toxicity by transforming them into amyloid fibrils, the mechanism described herein for GAG-mediated acceleration of 8 kDa gelsolin amyloidogenesis provides a starting point for therapeutic strategy development. The addition of GAG mimetics, small molecule sulfonates shown to reduce the amyloid load in animal models of amyloidosis, to a heparin-accelerated 8 kDa gelsolin aggregation reaction neither significantly alters the rate of amyloidogenesis nor prevents oligomers from binding to GAGs, calling into question their commonly accepted mechanism. PMID:21348501

Solomon, James P.; Bourgault, Steve; Powers, Evan T.; Kelly, Jeffery W.

2011-01-01

438

Analyzing the relation between the microbial diversity of DaQu and the turbidity spoilage of traditional Chinese vinegar.  

PubMed

Vinegar is a traditional fermented condiment, and the microbial diversity of DaQu makes the quality of vinegar products. Recently, turbidity spoilage of vinegar sharply tampered with the quality of vinegar. In this study, the relation between the microbial diversity of DaQu and turbidity spoilage of vinegar was analyzed by plating technique, PCR-denaturing gradient gel electrophoresis (DGGE), and high-performance liquid chromatography (HPLC). The 16S rRNA sequencing and DGGE analysis indicated that Bacillus (Bacillus subtilis, Bacillus amyloliquefaciens, and Bacillus thuringiensis) and Lactobacillus (including Lactobacillus acidipiscis and Lactobacillus pobuzihii) species were the dominant contaminants in vinegar products. Meanwhile, DGGE analysis showed that the dominant bacteria in DaQu belonged to genera Bacillus, Lactobacillus, Pseudomonas, Weissella, Saccharopolyspora, Enterobacter, and Pantoea. However, only two yeast species (Pichia kudriavzevii and Saccharomycopsis fibuligera) and seven mold species including Aspergillus oryzae, Aspergillus niger, Aspergillus candidus, Rhizopus microspores, Eurotium herbariorum, Absidia corymbifera, and Eupenicillium javanicum were detected in the DaQu. The population level of fungi was below 5 log CFU/g in DaQu. The chemical and physical properties of vinegar and sediments were also determined. On the basis of a combined microbial diversity-chemical analysis, we demonstrated that turbidity spoilage of vinegar was a result of cooperation among the low population level and abundance of fungal species in DaQu, the suitable climate conditions, and the contaminants in vinegar. This is the first report to analyze the relation between the microbial diversity of DaQu and turbidity spoilage of vinegar. PMID:24691870

Li, Pan; Li, Sha; Cheng, Lili; Luo, Lixin

2014-07-01

439

The effect of DA-8159 on corpus cavernosal smooth muscle relaxation and penile erection in diabetic rabbits.  

PubMed

A previous study showed that DA-8159, a potent type 5 phosphodiesterase inhibitor, enhanced the relaxation of the smooth muscles in the normal rabbit corpus cavernosum. In this study, we investigated the in vitro effects of DA-8159 on cavernosal smooth muscle relaxation and the in vivo erectogenic potential in diabetic rabbits, since erectile dysfunction is a well-known sequela of diabetes mellitus. Diabetes mellitus was induced in male New Zealand White rabbits with alloxan monohydrate. Cavernosal strips from age-matched control and 8-week diabetic animals were mounted in organ baths. The relaxation responses to sodium nitroprusside (10(-9)--10(-5) M), a nitric oxide donor, were assessed in the presence or absence of DA-8159 (10(-9)--10(-6) M). For the penile erection test, DA-8159 was given orally (1-10 mg/kg) to diabetic rabbits and the length of the uncovered penile shaft was measured in a time-course manner in the presence or absence of intravenous sodium nitroprusside. The sodium nitroprusside-stimulated relaxations were significantly impaired in the corpus cavernosum from the diabetic group (IC(50)=1.07 x 10(-6) M following 8 weeks of diabetes mellitus; compared with 0.48 x 10(-6) M for age-matched controls). DA-8159 significantly and dose-dependently enhanced the sodium nitroprusside-stimulated relaxation in the diabetic groups. In addition, DA-8159 induced a dose-dependent penile erection in diabetic rabbits, which was potentiated by intravenous sodium nitroprusside. These results suggest that DA-8159 is an effective treatment for diabetic erectile dysfunction but further evaluation of the efficacy on human needs to be performed. PMID:15024530

Kang, Kyung Koo; Choi, Seul Min; Ahn, Gook Jun; Kwon, Jong Won; Kim, Won Bae

2004-05-01

440

Immunoblot evaluation of the 100 and 130 kDa antigens in camel hydatid cyst fluid for the serodiagnosis of human cystic echinococcosis in Libya  

Microsoft Academic Search

Two high molecular weight antigens with molecular masses approximately 100 kDa and 130 kDa were identified by immunoblotting camel hydatid cyst fluid, with 94% sensitivity in sera from surgically confirmed Libyan cystic echinococcosis cases. 40% of sera from surgically confirmed alveolar echinococcosis cases cross-reacted with the 100 and 130 kDa antigens, as did 5·3% of sera from human Taenia solium

M. K. Shambesh; P. S. Craig; A. M. Gusbi; E. F. Echtuish; H. Wen

1995-01-01

441

Substance P Enhances the Production of Interferon-induced Protein of 10 kDa by Human Keratinocytes in Synergy with Interferon-?  

Microsoft Academic Search

A neuropeptide substance P is related to skin inflammation. Interferon-induced protein of 10 kDa (IP-10) chemoattracts T helper 1 cells, and interferon-induced protein of 10 kDa production by keratinocytes is enhanced in inflammatory skin diseases such as psoriasis. We examined the in vitro effects of substance P on interferon-induced protein of 10 kDa production by human keratinocytes. Though substance P

Naoko Kanda; Shinichi Watanabe

2002-01-01

442

The effect of DA8159, a novel PDE5 inhibitor, on erectile function in the rat model of hypercholesterolemic erectile dysfunction  

Microsoft Academic Search

This study examined the effects of a new phosphodiesterase type 5 inhibitor, DA-8159, on erectile function associated with hypercholesterolemia. First of all, in order to investigate whether chronic administration of DA-8159 prevents the development of erectile dysfunction associated with hypercholesterolemia, male SD rats were divided into four groups (normal control, hypercholesterolemic control, DA-8159 5 or 20 mg\\/kg\\/day). Over a 5-month

K K Kang; J Y Yu; M Yoo; J W Kwon

2005-01-01

443

Apple chlorotic leaf spot virus 50 kDa protein is targeted to plasmodesmata and accumulates in sieve elements in transgenic plant leaves  

Microsoft Academic Search

Summary.  ?We investigated the in situ localization of the 50 kDa protein encoded by ORF2 of Apple chlorotic leaf spot virus (ACLSV) genome which is thought to be a movement protein. In immunogold electron microscopy of ACLSV-infected Chenopodium quinoa leaves, the 50 kDa protein was localized on plasmodesmata and nearby cytoplasm. Observation of transgenic Nicotiana occidentalis leaves expressing the 50 kDa

N. Yoshikawa; S. Oogake; M. Terada; S. Miyabayashi; Y. Ikeda; T. Takahashi; K. Ogawa

1999-01-01

444

[The Vitruvian Man: an anatomical drawing for proportions by Leonardo Da Vinci].  

PubMed

The aim of the study was to find out and to analyse the text by Vitruvius which inspired the famous drawing by Leonardo da Vinci (circa 1490) kept in the Galleria dell'Accademia, in Venezia, Italy: the man inscribed in one circle and in one square. The book "de Architectura" by Vitruvius Marcus Pollio was printed several times since the Renaissance when both the roman architecture of antiquity and this text became very popular. From a French translation by Claude Perrault in 1864, it became easy to find a French translation with the original text in Latin (Paris, 2003, Les Belles Lettres, French text by Pierre Gros). The drawing by Leonardo da Vinci illustrates with great accuracy and fidelity the quotation of Vitruvius (with the exception of two of the 12 main relationships). The genius of Leonardo da Vinci was to keep only one trunk, head and neck for two pairs of limbs: scapular and pelvic; to make the circle tangent to the lower edge of the square; to adjust a few features of the quotation for the equilibrium of the whole figure; and of course to bring his incredible skill as a drawer (one of the best of his century). The drawing was made on a sheet of paper 344x245mm, in black ink which became dark brown with time; several lines complete the figure above and below; a short caption and a horizontal scale appear just under the drawing. The celebrity of the drawing, a symbol of the Renaissance, of the equilibrium of man and mankind, of the universality of the artists and intellectuals of the time (Humanism) made it iconic and it has been constantly reproduced and adapted especially for advertisement and logos, not only in the medical field. PMID:18951824

Le Floch-Prigent, P

2008-12-01

445

Structural requirements to obtain highly potent and selective 18 kDa Translocator Protein (TSPO) Ligands.  

PubMed

The (18 kDa) Translocator Protein (TSPO), was initially identified in 1977 as peripheral binding site for the benzodiazepine diazepam and named "Peripheral-type benzodiazepine receptor (PBR)". It is an evolutionarily well-conserved protein particularly located at the outer/inner mitochondrial membrane contact sites, in closely association with the 32 kDa voltage-dependent anion channel (VDAC) and the 30 kDa adenine nucleotide translocase (ANT), thus forming the mitochondrial permeability transition pore (MPTP). TSPO is ubiquitary expressed in peripheral tissues (steroid producing tissues, liver, heart, kidney, lung, immune system) and in lower levels in the central nervous system, where it is mainly located in glial cells, and in neurons. TSPO is involved in a variety of biological processes such as cholesterol transport, steroidogenesis, calcium homeostasis, lipid metabolism, mitochondrial oxidation, cell growth and differentiation, apoptosis induction, and regulation of immune functions. In the last decade, many studies have reported that TSPO basal expression is altered in a number of human pathologies, such as cancer and neurodegenerative disorders (Huntington's and Alzheimer's diseases), as well as in various forms of brain injury and inflammation and anxiety. Consequently, TSPO has not only been suggested as a promising drug target for a number of therapeutic applications (anticonvulsant, anxiolytic, immunomodulating, etc.), but also as valid diagnostic marker for related-disease state and progression, prompting the development of specific labelled ligands as powerful tools for imaging techniques. A number of structurally different classes of ligands have been reported, showing high affinity and selectivity towards TSPO. Indeed, most of these ligands have been designed starting from selective CBR ligands which were structurally modified in order to shift their affinity towards TSPO. Extensive structure-activity relationship studies were performed allowing to hypothesize various TSPO pharmacophore models. The purpose of this paper is to highlight the structural requirements needed to obtain TSPO ligands with high affinity and selectivity. PMID:21291396

Taliani, Sabrina; Pugliesi, Isabella; Da Settimo, Federico

2011-01-01

446

Identification and characterization of a 26- to 28-kDa circulating antigen of Fasciola gigantica.  

PubMed

As a disease of domestic ruminants, fascioliasis is of considerable economic importance. Although serological tests are available for the diagnosis of the disease, they are of generally low specificity because of cross-reactivity with antigens from other parasites. There is a need to identify other Fasciola antigens on which more specific tests could be based. In the present study, a specific rabbit anti-serum and western-blot analyses were used to demonstrate the presence of a highly reactive antigen of 26-28 kDa not only in an extract of adult F. gigantica but also in the excretory/secretory products of the worms and in the bile secretions and sera of cattle that were naturally infected with this parasite. The 26- to 28-kDa antigen was isolated from preparative polyacrylamide gels, by electro-elution. The purified antigen showed a single peak at 5.8 min when analysed by capillary zone electrophoresis. It was characterized as protein containing 47.5% hydrophilic and 29.3% hydrophobic amino acids. Immunostaining demonstrated that the target epitope was located in the gut and tegument of adult F. gigantica and within the bile ducts, the portal tracts of the livers and the mucosa and muscularis of the gallbladders of infected cattle. A simple and rapid dot-ELISA technique based on the specific rabbit anti-serum was 100% specific when tested on the sera from nine cattle infected with F. gigantea and 27 uninfected cattle. In conclusion, the 26- to 28-kDa Fasciola antigen may be a promising candidate for the immunodiagnosis of fascioliasis. PMID:12061974

Attallah, A M; Karawia, E A; Ismail, H; Tabll, A A; Nawar, A A; Ragab, W A; Abdel Aziz, M M; El-Dosoky, I

2002-04-01

447

Efeito da disponibilidade de sítios de nidificação sobre o sistema de acasalamento e o cuidado paternal em um opilião neotropical (Arachnida: Opiliones).  

E-print Network

??Cavidades naturais constituem um recurso reprodutivo monopolizável, cuja disponibilidade determina a intensidade da competição macho-macho que, por sua vez, pode influenciar os custos do cuidado… (more)

Rachel Miranda Werneck

2012-01-01

448

Efeitos da ingestão de Ayahuasca em estados psicométricos relacionados ao pánico, ansiedade e depressão em membros do culto do Santo Daime.  

E-print Network

??Dissertação (mestrado)—Universidade de Brasília, Instituto de Psicologia, 2006. A utilização da ayahuasca, cujo uso religioso é legitimado juridicamente no Brasil desde 1986, vem crescendo nos… (more)

Santos, Rafael Guimarães dos

2006-01-01

449

The Ubiquitin Receptor DA1 Regulates Seed and Organ Size by Modulating the Stability of the Ubiquitin-Specific Protease UBP15/SOD2 in Arabidopsis[W  

PubMed Central

Although the control of organ size is a fundamental question in developmental biology, little is known about the genetic and molecular mechanisms that determine the final size of seeds in plants. We previously demonstrated that the ubiquitin receptor DA1 acts synergistically with the E3 ubiquitin ligases DA2 and ENHANCER1 OF DA1 (EOD1)/BIG BROTHER to restrict seed growth in Arabidopsis thaliana. Here, we describe UBIQUITIN-SPECIFIC PROTEASE15 (UBP15), encoded by SUPPRESSOR2 OF DA1 (SOD2), which acts maternally to regulate seed size by promoting cell proliferation in the integuments of ovules and developing seeds. The sod2/ubp15 mutants form small seeds, while overexpression of UBP15 increases seed size of wild-type plants. Genetic analyses indicate that UBP15 functions antagonistically in a common pathway with DA1 to influence seed size, but does so independently of DA2 and EOD1. Further results reveal that DA1 physically associates with UBP15 in vitro and in vivo and modulates the stability of UBP15. Therefore, our findings establish a genetic and molecular framework for the regulation of seed size by four ubiquitin-related proteins DA1, DA2, EOD1, and UBP15 and suggest that they are promising targets for increasing seed size in crops. PMID:24585836

Du, Liang; Li, Na; Chen, Liangliang; Xu, Yingxiu; Li, Yu; Zhang, Yueying; Li, Chuanyou; Li, Yunhai

2014-01-01

450

82-kDa choline acetyltransferase is in nuclei of cholinergic neurons in human CNS and altered in aging and Alzheimer disease  

Microsoft Academic Search

Cholinergic neurons express choline acetyltransferase (ChAT) which synthesizes acetylcholine. We show here for the first time that primate-specific 82-kDa ChAT is expressed in nuclei of cholinergic neurons in human brain and spinal cord; isoform-specific antibodies were used to compare localization patterns and temporal expression of the more abundant 69-kDa ChAT and primate-specific 82-kDa ChAT in necropsy tissues. The 82-kDa ChAT

Sandeep K. Gill; Margaret Ishak; Tomas Dobransky; Vahram Haroutunian; Kenneth L. Davis; R. Jane Rylett

2007-01-01

451

Fifty-seven-kDa protein in royal jelly enhances proliferation of primary cultured rat hepatocytes and increases albumin production in the absence of serum.  

PubMed

We have previously shown that 57-kDa protein in royal jelly (RJ) was specifically degraded in proportion to both storage temperature and storage period, and we suggested that it could be useful as a marker of freshness of RJ (Kamakura, M., Fukuda, T., Fukushima, M. and Yonekura, M. (2001) Biosci. Biotechnol. Biochem. 65, 277-284.). Here, we investigated the physiological effects of 57-kDa protein on primary cultured rat hepatocytes in the absence of serum. The 57-kDa protein and RJ significantly stimulated hepatocyte DNA synthesis, whereas bovine serum albumin and RJ stored at 40 degrees C for 7 days, which lacks 57-kDa protein, did not. The mitogenic activity of 57-kDa protein was lost after treatment with trypsin. These results indicate that 57-kDa protein acts as a mitogen. The stimulatory effect of 57-kDa protein was dose-dependent and was more potent at lower than at higher cell densities. The 57-kDa protein also prolonged the cell proliferation of primary cultured rat hepatocytes, with an enhancement of albumin production compared to untreated cells. Therefore, 57-kDa protein is likely to promote liver regeneration and may have a cytoprotective action on hepatocytes. PMID:11352630

Kamakura, M; Suenobu, N; Fukushima, M

2001-04-13

452

Orthosteric Binding of ?-Da1a, a Natural Peptide of Snake Venom Interacting Selectively with the ?1A-Adrenoceptor  

PubMed Central

?-Da1a is a three-finger fold toxin from green mamba venom that is highly selective for the ?1A-adrenoceptor. This toxin has atypical pharmacological properties, including incomplete inhibition of 3H-prazosin or 125I-HEAT binding and insurmountable antagonist action. We aimed to clarify its mode of action at the ?1A-adrenoceptor. The affinity (pKi 9.26) and selectivity of ?-Da1a for the ?1A-adrenoceptor were confirmed by comparing binding to human adrenoceptors expressed in eukaryotic cells. Equilibrium and kinetic binding experiments were used to demonstrate that ?-Da1a, prazosin and HEAT compete at the ?1A-adrenoceptor. ?-Da1a did not affect the dissociation kinetics of 3H-prazosin or 125I-HEAT, and the IC50 of ?-Da1a, determined by competition experiments, increased linearly with the concentration of radioligands used, while the residual binding by ?-Da1a remained stable. The effect of ?-Da1a on agonist-stimulated Ca2+ release was insurmountable in the presence of phenethylamine- or imidazoline-type agonists. Ten mutations in the orthosteric binding pocket of the ?1A-adrenoceptor were evaluated for alterations in ?-Da1a affinity. The D1063.32A and the S1885.42A/S1925.46A receptor mutations reduced toxin affinity moderately (6 and 7.6 times, respectively), while the F862.64A, F2886.51A and F3127.39A mutations diminished it dramatically by 18- to 93-fold. In addition, residue F862.64 was identified as a key interaction point for 125I-HEAT, as the variant F862.64A induced a 23-fold reduction in HEAT affinity. Unlike the M1 muscarinic acetylcholine receptor toxin MT7, ?-Da1a interacts with the human ?1A-adrenoceptor orthosteric pocket and shares receptor interaction points with antagonist (F862.64, F2886.51 and F3127.39) and agonist (F2886.51 and F3127.39) ligands. Its selectivity for the ?1A-adrenoceptor may result, at least partly, from its interaction with the residue F862.64, which appears to be important also for HEAT binding. PMID:23935897

Maïga, Arhamatoulaye; Merlin, Jon; Marcon, Elodie; Rouget, Céline; Larregola, Maud; Gilquin, Bernard; Fruchart-Gaillard, Carole; Lajeunesse, Evelyne; Marchetti, Charles; Lorphelin, Alain; Bellanger, Laurent; Summers, Roger J.; Hutchinson, Dana S.; Evans, Bronwyn A.; Servent, Denis; Gilles, Nicolas

2013-01-01

453

Revised Estimate of the Cenozoic Motion Between the Tristan da Cunha Hotspot and Pacific Hotspots  

NASA Astrophysics Data System (ADS)

We present a new method for objectively estimating the uncertainties of finite rotations of plates relative to hotspots. The input for our analysis are coeval dated locations along two or more ancient hotspot tracks, as well as the present locations of the hotspots. The output is a covariance matrix that can be used for testing hypotheses and for constructing confidence regions. Unlike prior methods, our method incorporates the uncertainties in all 3 degrees of freedom of a finite rotation. We apply our method to the Hawaiian and Louisville tracks on the Pacific plate and used the results to predict the track (and uncertainties) of the Tristan da Cunha hotspot on the Nubian plate. The Tristan da Cunha track provides a critical test for the fixed hotspot hypothesis because it has a fairly continuous track and has remained beneath the Nubian plate for the past 70 Myr and thus has not (in that time interval) greatly interacted with a mid-ocean ridge, which can severely complicate the track. In contrast to the results of prior studies, the predicted and observed Tristan da Cunha tracks have no significant differences for the past 48 Myr, which includes reconstructions for 11 Ma (chron 5), 20 Ma (chron 6), 33 Ma (chron 13), and 39 Ma (chron 18). For example, the predicted location of the Tristan hotspot at 48 Ma (chron 21) is about 100 km (+/- 250 km) from the nearest point on the Walvis Ridge, corresponding to motion between hotspots of 2 mm/yr +/- 5 mm/yr. Numerical experiments indicate that the improvement to the fit to the fixed hotspot assumption for reconstructions over the past 48 Myr come from many sources including improvements to the geomagnetic reversal time scale, improvements in relative plate reconstructions, improvements in Pacific-hotspot rotation parameters, and improvements to age dates along the Hawaiian-Emperor chain. Unlike the reconstructions for the past 48 Myr, reconstructions for 56 Ma (chron 25) and 68 Ma (chron 31) have huge misfits between predicted and observed tracks. For example, the misfit between the predicted and observed point at 68 Ma (chron 31) is 1000 +/- 250 km. A possible, but unlikely, explanation is that from 68 to 48 Ma, the Tristan da Cunha hotspot moved relative to the Pacific hotspots at a rate of 50 +/- 12 mm/yr. An alternative explanation is that the misfit is largely accommodated by a "missing" plate boundary in the early Tertiary and Late Cretaceous global plate motion circuit, as is independently indicated by global paleomagnetic data [Acton & Gordon, 1994].

Andrews, D. L.; Gordon, R. G.

2003-12-01

454

HyDA-Vista: towards optimal guided selection of k-mer size for sequence assembly  

PubMed Central

Motivation Intimately tied to assembly quality is the complexity of the de Bruijn graph built by the assembler. Thus, there have been many paradigms developed to decrease the complexity of the de Bruijn graph. One obvious combinatorial paradigm for this is to allow the value of k to vary; having a larger value of k where the graph is more complex and a smaller value of k where the graph would likely contain fewer spurious edges and vertices. One open problem that affects the practicality of this method is how to predict the value of k prior to building the de Bruijn graph. We show that optimal values of k can be predicted prior to assembly by using the information contained in a phylogenetically-close genome and therefore, help make the use of multiple values of k practical for genome assembly. Results We present HyDA-Vista, which is a genome assembler that uses homology information to choose a value of k for each read prior to the de Bruijn graph construction. The chosen k is optimal if there are no sequencing errors and the coverage is sufficient. Fundamental to our method is the construction of the maximal sequence landscape, which is a data structure that stores for each position in the input string, the largest repeated substring containing that position. In particular, we show the maximal sequence landscape can be constructed in O(n + n log n)-time and O(n)-space. HyDA-Vista first constructs the maximal sequence landscape for a homologous genome. The reads are then aligned to this reference genome, and values of k are assigned to each read using the maximal sequence landscape and the alignments. Eventually, all the reads are assembled by an iterative de Bruijn graph construction method. Our results and comparison to other assemblers demonstrate that HyDA-Vista achieves the best assembly of E. coli before repeat resolution or scaffolding. Availability HyDA-Vista is freely available [1]. The code for constructing the maximal sequence landscape and choosing the optimal value of k for each read is also separately available on the website and could be incorporated into any genome assembler. PMID:25558875

2014-01-01

455

OCT structural examination of Madonna dei Fusi by Leonardo da Vinci  

NASA Astrophysics Data System (ADS)

Madonna dei Fusi (`Madonna of the Yarnwider') is a spectacular example of Italian Renaissance painting, attributed to Leonardo da Vinci. The aim of this study is to give an account of past restoration procedures. The evidence of a former retouching campaign will be presented with cross-sectional images obtained non-invasively with Optical Coherence Tomography (OCT). Specifically, the locations of overpaintings/retouchings with respect to the original paint layer and secondary varnishes will be given. Additionally, the evidence of a former transfer of the pictorial layer to the new canvas support by detecting the presence of its structure incised into paint layer will be shown.

Targowski, Piotr; Iwanicka, Magdalena; Sylwestrzak, Marcin; Kaszewska, Ewa A.; Frosinini, Cecilia

2013-05-01

456

[Science and nation: romanticism and natural history in the works of E. J. da Silva Maia].  

PubMed

The works of physician and naturalist Emílio Joaquim da Silva Maia (1808-59) can be viewed as a scientific project that discovers Brazil and its inhabitants. Maia's nationalism and his romantic view of nature formed the underpinnings of his scientific theories, especially his studies on zoological geography. He subordinated the issue of the biological specificity of different regions of the world to his era's debates on the construction of Brazil as an independent nation. In his interpretations of European natural history, Maia endeavored to understand Brazilian nature as a specific achievement of the Cosmos, in keeping with Alexander von Humboldt's approach. PMID:16676427

Kury, L

1998-01-01

457

Condições físicas do disco de acréscimo da nova-anã V4140 SGR  

NASA Astrophysics Data System (ADS)

Discos de acréscimo são aparatos cósmicos que permitem que matéria seja eficientemente acrescida sobre uma fonte compacta pela remoção de momento angular via tensões viscosas enquanto transforma a energia potencial gravitacional em calor e, posteriormente, em radiação. Sistemas binários semi-ligados, como Variáveis Cataclísmicas (VCs) não-magnéticas, são talvez os melhores ambientes encontrados para o estudo da física desses discos de acréscimo. O desenvolvimento de técnicas de imageamento indireto, como o mapeamento por eclipses (MME) e a tomografia Doppler, permitiu avanços importantes na compreensão da física dos processos de acréscimo desses sistemas. V4140 Sagitarii é uma VC eclipsante de curto período orbital (~ 90 min) que não havia sido classificada como nova-anã ou polar. Neste trabalho apresentamos a análise do mapeamento por eclipse feito com dados de fotometria CCD nas bandas B, V e R de V4140 Sgr realizada no LNA. O objeto foi observado no declínio de erupção em julho de 1992 e em erupção em julho de 2001, isso indicou a classificação do sistema como uma nova-anã. A análise, feita sobre os mapas já apresentados em trabalho anterior, apresenta (i) diagrama cor-cor, que indica uma emissão opticamente espessa nas partes internas do disco em quiescência (R < RL1); (ii) diagrama cor-magnitude, usado para inferir uma distância de 600 +/- 10 pc ao sistema; (iii) a distribuição radial de temperatura observada que concorda com a lei de disco espesso em estado estacionário TµR-3/4, com temperaturas em torno de 10000 K e 3000 K ns partes internas e externas do disco em quiescência, respectivamente; (iv) a evolução da distribuição de temperatura no declínio de erupção; (v) estimativa da transferência de massa de 109.9+/-0.1 M¤/ano em quiescência, similar àquelas observadas em novas-like. O sistema é comparado à outras novas-anãs (e.g. OY Car e Z Cha) em quiescência e erupção, mostrando-se tratar um objeto peculiar que difere em vários aspectos o comportamento esperado de novas-anãs.

Borges, B.; Baptista, R.

2003-08-01

458

MA092 Geometria plana e analitica Comprimento da circunfer^encia -Area do circulo  

E-print Network

MA092 ­ Geometria plana e anal´itica Comprimento da circunfer^encia - ´Area do c´irculo Francisco A) 51.758 voltas Francisco A. M. Gomes (UNICAMP - IMECC)MA092 ­ Geometria plana e anal´itica Setembro de´itica Setembro de 2014 5 / 14 ´Area do c´irculo C´irculo ´Area A ´area de um c´irculo de raio R ´e dada por AC

Gomes, Francisco A. M.

459

Middle Paleolithic human remains from the Gruta da Oliveira (Torres Novas), Portugal.  

PubMed

Ongoing excavations in the Middle Paleolithic levels at the Gruta da Oliveira, Portugal have yielded four fragmentary human remains, a manual phalanx and an ulna from levels 9 and 10, and a humerus and a tibia from levels 18 and 19. The first two remains date to approximately 39 ka 14C BP ( approximately 43.5 ka cal BP), whereas the latter two derive from earlier in oxygen isotope stage 3. The preserved portions of the phalanx, humerus, and tibia align them morphologically with the Neandertals. In addition, the Oliveira 4 tibial diaphysis shows evidence of carnivore (probably canid) gnawing. PMID:17632802

Trinkaus, Erik; Maki, Julia; Zilhão, João

2007-10-01

460

New paleomagnetic constraints on the extrusion of Indochina: Late Cretaceous results from the Song Da terrane, northern Vietnam  

NASA Astrophysics Data System (ADS)

Samples were collected for paleomagnetic investigations from the Upper Cretaceous Yen Chau Formation in the Song Da terrane (21.7°N, 103.9°E) bounded by the Ailao Shan-Red River fault system and Song Ma fault, in an attempt to examine extrusion tectonics of East Asia. Primary nature of the high-temperature (600-690 °C) component of magnetization from 13 sites is supported by a positive fold test. The tectonic corrected data provides the characteristic Late Cretaceous paleomagnetic direction for the Song Da terrane ( D=6.4°, I=32.0° with ?95=8.5°, N=13 sites), corresponding to a paleopole lying at 82.9°N, 220.7°E ( A95=6.9°). Comparison with coeval paleomagnetic poles for the neighboring tectonic blocks indicates no latitudinal translation of the Son Da terrane with respect to the South China Block, whereas the Shan-Thai Block and the southern part of the Indochina Block revealed a southward displacement of 10.5±9.5° in latitude with respect to the Song Da terrane. We conclude that the southeastern segment of the Ailao Shan-Red River fault system to the east of the Dien Bien Phu fault is not a demarcation of the extruded Indochina Peninsula. The Indochina Block extruded probably along some faults between the Song Da terrane and the Khorat Plateau.

Takemoto, Kazuhiro; Halim, Nadir; Otofuji, Yo-ichiro; Van Tri, Tran; Van De, Le; Hada, Shigeki

2005-01-01

461

Seasonal regulation of a 24-kDa protein from red-osier dogwood (Cornus sericea) xylem.  

PubMed

Previously, we showed that an apparent cell wall-plasma membrane interaction in xylem ray parenchyma differed between cold acclimated and non-acclimated red-osier dogwood (Cornus sericea L.) (Ristic and Ashworth 1994). For the present study, a calcium chloride extraction method was used to identify cell-wall-associated xylem proteins that accumulated during periods of cold acclimation. A 24-kDa protein represented the predominant protein in both total protein and CaCl2 extracts during cold acclimation of field-grown plants. Two-dimensional gel electrophoresis separated the 24-kDa protein into four basic isoforms. The most abundant and basic isoform had a high glycine content. In-gel digestion of this basic 24-kDa isoform generated three partial peptide fragments, of which one exhibited homology to the dehydrin protein family. An anti-dehydrin polyclonal antibody cross-reacted with the 24-kDa protein, providing further evidence that this protein is related to dehydrins. The 24-kDa protein began to accumulate in late August, reached a maximum in midwinter, declined during the spring months and was absent in early summer. PMID:11960767

Sarnighausen, Eric; Karlson, Dale; Ashworth, Edward

2002-04-01

462

Evidence that the 59-kDa protein synthesis initiation factor from wheat germ is functionally similar to the 80-kDa initiation factor 4B from mammalian cells.  

PubMed

The results of this investigation show that the 59-kDa protein synthesis initiation factor from wheat germ, designated eukaryotic initiation factor (eIF)-4G by Browning et al. (Browning, K.S., Maia, D.M., Lax, S.R., and Ravel, J.M. (1987) J. Biol. Chem. 262, 539-541), cross-links to the 5'-terminal cap of oxidized mRNA in the presence of eIF-4A, eIF-4F, and ATP, stimulates the RNA-dependent ATPase activities of eIF-4A and a mixture of eIF-4A and eIF-4F, and stimulates the unwinding activities of eIF-4A, eIF-4F, and a mixture of eIF-4A and eIF-4F. These findings strongly suggest that the 59-kDa factor from wheat germ is the functional equivalent of the 80-kDa protein synthesis initiation factor, eIF-4B, from mammalian cells. Recent reports indicate that the wheat germ initiation factor which contains two subunits of 80 and 28 kDa and which was given the designation "eIF-4B" by Lax et al. (Lax, S.R., Lauer, S.J., Browning, K. S., and Ravel, J.M. (1986) Methods Enzymol. 118, 109-128) is an isozyme form of eIF-4F and not the functional equivalent of mammalian eIF-4B. On the basis of functional characteristics we propose that the designation for the wheat germ factor containing the 80- and 28-kDa polypeptides be changed from eIF-4B to eIF-(iso)4F and the designation for the 59-kDa factor be changed from eIF-4G to eIF-4B. PMID:2722784

Browning, K S; Fletcher, L; Lax, S R; Ravel, J M

1989-05-25

463

Identification of a 45-kDa protein at the protein import site of the yeast mitochondrial inner membrane.  

PubMed Central

Import of proteins into mitochondria involves the cooperation of protein translocation systems in the outer and inner membranes. We have identified a 45-kDa protein at the protein import site of the yeast mitochondrial inner membrane. This 45-kDa protein could be crosslinked to a partly translocated precursor, which cannot be imported across the inner membrane when the matrix is depleted of ATP. In addition, an antibody against this protein strongly inhibited protein import into right-side-out inner-membrane vesicles. The 45-kDa protein accounts for only 0.1% of mitochondrial protein and appears peripherally attached to the outer face of the inner membrane. The properties of this protein suggest that it is a component of the protein import system of the mitochondrial inner membrane. Images PMID:1465421

Scherer, P E; Manning-Krieg, U C; Jenö, P; Schatz, G; Horst, M

1992-01-01

464

Generation of a multi-band spectrum using a D/A converter for an RF-knockout system  

NASA Astrophysics Data System (ADS)

A method of generating a multi-band spectrum is proposed using a digital-to-analog (D/A) converter. The multi-band spectrum is useful for the slow-beam-extraction from a synchrotron using the method of radio frequency (RF)-knockout. Data for the spectrum are calculated in advance to be saved in the memory of a D/A converter, and are output synchronized with external clocks. An experiment showed that a multi-band spectrum of 10 bands could be generated with a total bandwidth of about 16.4 MHz and each bandwidth less than 45 kHz. Beam simulation with this method showed that an RF signal from a D/A converter could be effectively used for the control of uniform spill structure.

Shinkai, Akio; Ishikawa, Soichiro; Nakanishi, Tetsuya

2015-01-01

465

Detection of serum antibodies against Leishmania 94 kDa antigen in visceral and cutaneous leishmaniosis due to Leishmania infantum.  

PubMed

Leishmania promastigotes polypeptides are analyzed by immunoblotting with sera from patients infected with different Leishmania species and presenting visceral or cutaneous infections. These sera recognize Leishmania polypeptides in several molecular masses. The major findings of this study are as follow. 1) The Leishmania 94 kDa antigen, which is specifically recognized by all sera from L. infantum-infected patients with visceral infection, is recognized by some sera from L. infantum-infected patients presenting cutaneous infection. 2) All patients with cutaneous infections due to L. tropica, L. amazonensis, or L. guyanensis do not develop anti-94 kDa antibodies, whatever the Leishmania species used as antigens. 3) Difference in electrophoretic mobilities is seen between the 94 kDa antigen identified by sera from Leishmania infantum-infected patients, and the antigen both recognized by the Concavalin A lectin and a rabbit antiserum raised against deglycosylated Promastigote Surface Protease. PMID:9137640

Rolland, L; Belkaid, M; Seye, A; Schneider, P; Gentilini, M

1995-03-01

466

Phosphorylation of a 60 kDa polypeptide from Xenopus oocytes blocks messenger RNA translation.  

PubMed Central

The stored mRNP particles of Xenopus oocytes contain protein kinase activity and two major phosphoproteins of 60 kDa (pp60) and 56 kDa (pp56). These proteins can be phospholabelled in the particles either in vivo or in vitro and then isolated by SDS-PAGE. On renaturing pp60 in the presence of globin mRNA, a stable RNA-protein complex is formed. The complex has a uniform density in Cs salt gradients, corresponding to the binding of about 10 protein molecules to each mRNA, probably at the poly(A) sequence. Compared with uncomplexed mRNA, the RNP complex is translated poorly both in vitro and in vivo. Translation of the complex can be regained after treatment with protein phosphatase. It is shown that dephosphorylation destabilizes the binding of protein to RNA, making the mRNA accessible for translation. Studies with native mRNP particles show that their translation also can be enhanced by dephosphorylation. Images PMID:2884624

Kick, D; Barrett, P; Cummings, A; Sommerville, J

1987-01-01

467

Genes influencing spinal bone mineral density in inbred F344, LEW, COP, and DA rats  

PubMed Central

Previously, we identified the regions of chromosomes 10q12–q31 and 15p16–q21 harbor quantitative trait loci (QTLs) for lumbar volumetric bone mineral density (vBMD) in female F2 rats derived from Fischer 344 (F344) × Lewis (LEW) and Copenhagen 2331 (COP) × Dark Agouti (DA) crosses. The purpose of this study is to identify the candidate genes within these QTL regions contributing to the variation in lumbar vBMD. RNA was extracted from bone tissue of F344, LEW, COP, and DA rats. Microarray analysis was performed using Affymetrix Rat Genome 230 2.0 Arrays. Genes differentially expressed among the rat strains were then ranked based on the strength of the correlation with lumbar vBMD in F2 animals derived from these rats. Quantitative PCR (qPCR) analysis was performed to confirm the prioritized candidate genes. A total of 285 genes were differentially expressed among all strains of rats with a false discovery rate less than 10%. Among these genes, 18 candidate genes were prioritized based on their strong correlation (r2 > 0.90) with lumbar vBMD. Of these, 14 genes (Akap1, Asgr2, Esd, Fam101b, Irf1, Lcp1, Ltc4s, Mdp-1, Pdhb, Plxdc1, Rabep1, Rhot1, Slc2a4, Xpo4) were confirmed by qPCR. We identified several novel candidate genes influencing spinal vBMD in rats. PMID:19841953

Alam, Imranul; Sun, Qiwei; Koller, Daniel L.; Liu, Lixiang; Liu, Yunlong; Edenberg, Howard J.; Foroud, Tatiana

2009-01-01

468

Enrichment and immunoprecipitation of 22 kDa human growth hormone spiked into human urine.  

PubMed

Approaches to detect whether an athlete has used growth hormone have been intensely investigated by sport organizations for 20 years. This effort has led to a human growth hormone (hGH) isoform ratio test in serum that has been approved by WADA and deployed at three Olympic Games, although a positive case has yet to be reported. We set out to determine whether the ratio test could be applied to urine. First we investigated various ways to extract hGH from spiked urine. We were able to recover 95% using selective centrifugal concentration. This fraction was then subjected to four different commercially available immunoprecipitation kits. The highest yield was obtained with the Invitrogen Dynabeads Protein G kit. Nevertheless it is apparent that these methods do not recover enough hGH for subsequent analysis by mass spectrometry. With further effort greater recovery of the 22 kDa isoform might be achieved, however it is very unlikely that the 20 kDa isoform could be detected. This method may be significantly improved by the application of both nanoparticle and aptamer technology. PMID:20355229

Bane, T K; Timmons, M S; Kauffman, S J; Catlin, D H

2009-09-01

469

UniDA: Uniform Device Access Framework for Human Interaction Environments  

PubMed Central

Human interaction environments (HIE) must be understood as any place where people carry out their daily life, including their work, family life, leisure and social life, interacting with technology to enhance or facilitate the experience. The integration of technology in these environments has been achieved in a disorderly and incompatible way, with devices operating in isolated islands with artificial edges delimited by the manufacturers. In this paper we are presenting the UniDA framework, an integral solution for the development of systems that require the integration and interoperation of devices and technologies in HIEs. It provides developers and installers with a uniform conceptual framework capable of modelling an HIE, together with a set of libraries, tools and devices to build distributed instrumentation networks with support for transparent integration of other technologies. A series of use case examples and a comparison to many of the existing technologies in the field has been included in order to show the benefits of using UniDA. PMID:22163700

Varela, Gervasio; Paz-Lopez, Alejandro; Becerra, Jose Antonio; Vazquez-Rodriguez, Santiago; Duro, Richard José

2011-01-01

470

Photospheric phosphorus in the FUSE spectra of GD71 and two similar DA white dwarfs  

E-print Network

We report the detection, from FUSE data, of phosphorus in the atmospheres of GD71 and two similar DA white dwarfs. This is the first detection of a trace metal in the photosphere of the spectrophotometric standard star GD71. Collectively, these objects represent the coolest DA white dwarfs in which photospheric phosphorus has been observed. We use a grid of homogeneous non-LTE synthetic spectra to measure abundances of[P/H]=-8.57 +0.09 -0.13, -8.70 +0.23 -0.37 and -8.36 +0.14 -0.19 in GD71, RE J1918+595 and RE J0605-482 respectively. At the observed level we find phosphorus has no significant impact on the overall energy distribution of GD71. We explore possible mechanisms responsible for the presence of this element in these stars, concluding that the most likely is an interplay between radiative levitation and gravitational settling but possibly modified by weak mass loss.

Paul Dobbie; Martin Barstow; Ivan Hubeny; Jay Holberg; Matt Burleigh; Anne Forbes

2005-07-27

471

Development of noSQL data storage for the ATLAS PanDA Monitoring System  

NASA Astrophysics Data System (ADS)

For several years the PanDA Workload Management System has been the basis for distributed production and analysis for the ATLAS experiment at the LHC. Since the start of data taking PanDA usage has ramped up steadily, typically exceeding 500k completed jobs/day by June 2011. The associated monitoring data volume has been rising as well, to levels that present a new set of challenges in the areas of database scalability and monitoring system performance and efficiency. These challenges are being met with an R&D effort aimed at implementing a scalable and efficient monitoring data storage based on a noSQL solution (Cassandra). We present our motivations for using this technology, as well as data design and the techniques used for efficient indexing of the data. We also discuss the hardware requirements as they were determined by testing with actual data and realistic rate of queries. In conclusion, we present our experience with operating a Cassandra cluster over an extended period of time and with data load adequate for planned application.

Ito, H.; Potekhin, M.; Wenaus, T.

2012-12-01

472

Development of noSQL data storage for the ATLAS PanDA Monitoring System  

E-print Network

For several years the PanDA Workload Management System has been the basis for distributed production and analysis for the ATLAS experiment at the LHC. Since the start of data taking PanDA usage has ramped up steadily, typically exceeding 500k completed jobs/day by June 2011. The associated monitoring data volume has been rising as well, to levels that present a new set of challenges in the areas of database scalability and monitoring system performance and efficiency. These challenges are being met with an R&D effort aimed at implementing a scalable and efficient monitoring data storage based on a noSQL solution (Cassandra). We present our motivations for using this technology, as well as data design and the techniques used for efficient indexing of the data. We also discuss the hardware requirements as they were determined by testing with actual data and realistic rate of queries. In conclusion, we present our experience with operating a Cassandra cluster over an extended period of time and with data loa...

Ito, H; Wenaus, T

2012-01-01

473

Safety Analysis of 10 Clinical Trials and for 13 Years After First Approval of Ioflupane 123I Injection (DaTscan).  

PubMed

Ioflupane is an analog of cocaine that binds reversibly with high affinity to the dopamine transporter (DaT) protein, a marker for presynaptic terminals in dopaminergic nigrostriatal neurons. Ioflupane (123)I Injection is also known as DaTscan or DaTSCAN ((123)I-ioflupane is also called (123)I-2-?-carbomethoxy-3?-(4-iodophenyl)-N-(3-fluoropropyl)nortropane or (123)I-FP-CIT). The diagnostic efficacy of DaTscan has been described elsewhere. Here, we present a comprehensive analysis of the safety of DaTscan starting from initiation of clinical development through 13 y after the date of first market approval. Safety data in the sponsor's clinical development safety database from 10 completed DaTscan clinical trials were pooled, and postapproval experience was summarized from standardized aggregate safety reports submitted to regulatory agencies. A total of 1,180 clinical trial subjects (92% of 1,284 subjects planned to receive DaTscan in the clinical trials) received DaTscan. Percentages of subjects with adverse events by category were as follows: all (22%), considered at least possibly related to DaTscan by the investigator (4%), any severe (3%), headache (4%), nausea (2%), dizziness (2%), nasopharyngitis (1%), and injection site hematoma (1%). Four percent of subjects had at least 1 serious adverse event; 5 subjects (<1%) had serious adverse events that led to death. All serious adverse events, including those that led to death, were deemed by an expert clinician to be unrelated to DaTscan. An estimated half a million market doses of DaTscan (for single use) were administered from July 2000 through the July 2013 reporting period. In postapproval safety assessment, 1 death was reported 20 d after (and unrelated to) DaTscan administration. Two spontaneously reported serious adverse drug reactions (ADRs) and 32 spontaneously reported nonserious ADRs were submitted, approximately half of which are identified in labeling. Headache (in clinical trials) and injection site pain (postapproval) were the most commonly reported events or reactions. Although adverse events were reported for 1 in 5 clinical trial subjects, most were mild and considered unrelated to DaTscan administration. Severe events were uncommon, and no serious adverse event occurring in more than 1 subject was deemed related to DaTscan administration. In postapproval experience, the frequency of ADRs spontaneously reported was less than 1 per 10,000 doses administered. Comprehensive safety data show that DaTscan was well tolerated. PMID:24947061

Grosset, Donald G; Tatsch, Klaus; Oertel, Wolfgang H; Tolosa, Eduardo; Bajaj, Nin; Kupsch, Andreas; O'Brien, John T; Seibyl, John; Walker, Zuzana; Sherwin, Paul; Chen, Chris; Grachev, Igor D

2014-06-19

474

Observing the result of external magnetic field with nonextensivity on DA waves for two temperature electrons in a dusty plasmas  

NASA Astrophysics Data System (ADS)

This theoretical investigation has been made on dust-acoustic (DA) waves containing nonextensivity of electrons being two different temperatures, negatively charged dust grains, and Maxwellian ions. The Zakharov-Kuznetsov (Z-K) equation has been derived and numerically solved to analysis the basis features. It is observed that the characteristics of the DA solitary waves (DASWs) are significantly modified by the external magnetic field with the different temperatures for electrons followed by the nonextensive distribution. The results obtained from this analysis can be employed in understanding the nature of plasma waves both in laboratory and space plasma system.

Zobaer, M. S.; Roy, N.; Mamun, A. A.

2014-03-01

475

O universo do homem social e o lugar da realidade objetiva: Um diálogo entre Pierre Teilhard de Chardin e Milton Santos  

Microsoft Academic Search

Uma questão a respeito de nosso tempo que merece atenção reporta-se à condição do homem alienado. Sem a adequada consciência da dimensão evolutiva, social e cultural do espaço que lhe cabe à vida em comum, prossegue no curso da história produzindo um modo de vida destituído de preocupações teleológicas e, portanto, desvirtuado dos processos de personalização e socialização que condiz

Cilene Gomes

2009-01-01

476

Compartmentalization of the cellular immune response to the recombinant 65 kDa protein of Mycobacterium bovis BCG in patients with tuberculous pleuritis.  

PubMed

The recombinant 65 kDa mycobacterial protein of M. bovis BCG has been shown to be immunodominant in mice immunized with M. tuberculosis. Little is known about reactivity to this antigen in patients with tuberculous pleuritis. In this study therefore, pleural effusion and autologous peripheral blood lymphocytes obtained from patients with tuberculous and nontuberculous pleuritis were stimulated in-vitro with the recombinant 65 kDa antigen. Proliferation was assessed by 3[H] thymidine incorporation. In addition, pleural effusion lymphocytes were activated in vitro with the 65 kDa antigen and tested for cytotoxic activity in 15-hr chromium-release assays. Pleural effusion lymphocytes obtained from a high percentage (56%) of patients with tuberculous pleuritis showed significant proliferative responses to the 65 kDa antigen, while the response in autologous peripheral blood lymphocytes was significantly lower. By contrast, pleural effusion lymphocytes obtained from patients with nontuberculous effusions were not reactive to the 65 kDa antigen. In addition, 65 kDa stimulated pleural effusion lymphocytes obtained from patients with tuberculous effusions showed antigen-specific lysis of autologous targets pulsed with the 65 kDa antigen. These results indicate compartmentalization of the immune response to the 65 kDa antigen and, in addition, provide evidence for in vivo involvement of this antigen in the immune response to M. tuberculosis. PMID:1349232

Lorgat, F; Keraan, M M; Ress, S R

1992-01-01

477

To give or to send to Servizio Offerta Formativa Post Laurea -Campus Leonardo Edificio 2 -Piazza Leonardo da Vinci, 32 20133 Milano -Italy  

E-print Network

- Piazza Leonardo da Vinci, 32 ­ 20133 Milano - Italy Stamp duty at current value CERTIFICATES ON STAMPED Formativa Post Laurea ­ Campus Leonardo ­ Piazza Leonardo da Vinci, 32 ­ Padiglione Nord ­ Edificio 2To give or to send to Servizio Offerta Formativa Post Laurea - Campus Leonardo ­ Edificio 2

478

Semina: Cincias Biolgicas e da Sade, Londrina, v. 34, n. 1, p. 55-62, jan./jul. 2013 A comunicao da equipe de enfermagem com o paciente em cuidados  

E-print Network

A comunicação da equipe de enfermagem com o paciente em cuidados paliativos The communication of the nursing for effective communication among the nursing, terminally ill and his family. In that sense, it was observed aspects that enable developing empathic communication skills, perceived as a task that requires nursing

Paris-Sud XI, Université de

479

DaVIE: Database for the Visualization and Integration of Epigenetic data  

PubMed Central

One of the challenges in the analysis of large data sets, particularly in a population-based setting, is the ability to perform comparisons across projects. This has to be done in such a way that the integrity of each individual project is maintained, while ensuring that the data are comparable across projects. These issues are beginning to be observed in human DNA methylation studies, as the Illumina 450k platform and next generation sequencing-based assays grow in popularity and decrease in price. This increase in productivity is enabling new insights into epigenetics, but also requires the development of pipelines and software capable of handling the large volumes of data. The specific problems inherent in creating a platform for the storage, comparison, integration, and visualization of DNA methylation data include data storage, algorithm efficiency and ability to interpret the results to derive biological meaning from them. Databases provide a ready-made solution to these issues, but as yet no tools exist that that leverage these advantages while providing an intuitive user interface for interpreting results in a genomic context. We have addressed this void by integrating a database to store DNA methylation data with a web interface to query and visualize the database and a set of libraries for more complex analysis. The resulting platform is called DaVIE: Database for the Visualization and Integration of Epigenetics data. DaVIE can use data culled from a variety of sources, and the web interface includes the ability to group samples by sub-type, compare multiple projects and visualize genomic features in relation to sites of interest. We have used DaVIE to identify patterns of DNA methylation in specific projects and across different projects, identify outlier samples, and cross-check differentially methylated CpG sites identified in specific projects across large numbers of samples. A demonstration server has been setup using GEO data at http://echelon.cmmt.ubc.ca/dbaccess/, with login “guest” and password “guest.” Groups may download and install their own version of the server following the instructions on the project's wiki. PMID:25278960

Fejes, Anthony P.; Jones, Meaghan J.; Kobor, Michael S.

2014-01-01

480

DaVIE: Database for the Visualization and Integration of Epigenetic data.  

PubMed

One of the challenges in the analysis of large data sets, particularly in a population-based setting, is the ability to perform comparisons across projects. This has to be done in such a way that the integrity of each individual project is maintained, while ensuring that the data are comparable across projects. These issues are beginning to be observed in human DNA methylation studies, as the Illumina 450k platform and next generation sequencing-based assays grow in popularity and decrease in price. This increase in productivity is enabling new insights into epigenetics, but also requires the development of pipelines and software capable of handling the large volumes of data. The specific problems inherent in creating a platform for the storage, comparison, integration, and visualization of DNA methylation data include data storage, algorithm efficiency and ability to interpret the results to derive biological meaning from them. Databases provide a ready-made solution to these issues, but as yet no tools exist that that leverage these advantages while providing an intuitive user interface for interpreting results in a genomic context. We have addressed this void by integrating a database to store DNA methylation data with a web interface to query and visualize the database and a set of libraries for more complex analysis. The resulting platform is called DaVIE: Database for the Visualization and Integration of Epigenetics data. DaVIE can use data culled from a variety of sources, and the web interface includes the ability to group samples by sub-type, compare multiple projects and visualize genomic features in relation to sites of interest. We have used DaVIE to identify patterns of DNA methylation in specific projects and across different projects, identify outlier samples, and cross-check differentially methylated CpG sites identified in specific projects across large numbers of samples. A demonstration server has been setup using GEO data at http://echelon.cmmt.ubc.ca/dbaccess/, with login "guest" and password "guest." Groups may download and install their own version of the server following the instructions on the project's wiki. PMID:25278960

Fejes, Anthony P; Jones, Meaghan J; Kobor, Michael S

2014-01-01

481

Signal transduction mechanism leading to enhanced proliferation of primary cultured adult rat hepatocytes treated with royal jelly 57-kDa protein.  

PubMed

A 57-kDa protein in royal jelly (RJ) was previously shown to stimulate hepatocyte DNA synthesis and prolongs the proliferation of hepatocytes as well as increasing albumin production [Kamakura, M., Suenobu, N., and Fukushima, M. (2001) Biochem. Biophys. Res. Commun. 282, 865-874]. In this study, I investigated the signal transduction mechanisms involved in the induction of hepatocyte DNA synthesis and the promotion of cell survival by this 57-kDa protein in primary cultures of adult rat hepatocytes. Hepatocyte DNA synthesis induced by the 57-kDa protein was not influenced by several alpha- and beta-adrenoceptor antagonists, but was dose-dependently abolished by an inhibitor of a tyrosine-specific protein kinase, genistein. A phospholipase C inhibitor (U-73122) and a protein kinase C (PKC) inhibitor (sphingosine) inhibited 57-kDa protein-stimulated he-patocyte DNA synthesis, whereas a protein kinase A inhibitor (H-89) did not. The 57-kDa protein also activated PKC in rat hepatocytes. Various inhibitors of intracellular signal transduction elements (PD98059, p21 ras farnesyltransferase inhibitor, wortmannin and rapamycin) also blocked hepatocyte DNA synthesis induced by the 57-kDa protein. Furthermore, the 57-kDa protein activated mitogen-activated protein (MAP) kinase in rat hepatocytes. The activation of MAP kinase by the 57-kDa protein was inhibited by PD98059 and sphingosine. The 57-kDa protein also activated protein kinase B, which is a key regulator of cell survival. These results suggest that, like growth factors, the 57-kDa protein activates several important intracellular signaling factors involved in the stimulation of hepatocyte DNA synthesis and the protection of cells from apoptosis. PMID:12473193

Kamakura, Masaki

2002-12-01

482

The 30-kDa and 38-kDa antigens from Mycobacterium tuberculosis induce partial maturation of human dendritic cells shifting CD4+ T cell responses towards IL-4 production  

PubMed Central

Background Mycobacterium tuberculosis (Mtb) infections are still a major cause of death among all infectious diseases. Although 99% of individuals infected with Mtb develop a CD4+ Th1 and CD8+ T cell mediated immunity as measured by tuberculin skin test, this results only in partial protection and Mtb vaccines are not effective. Deviation of immune responses by pathogens towards a Th2 profile is a common mechanism of immune evasion, typically leading to the persistence of the microbes. Results Here we tested the stimulatory capacity of selective Mtb antigens on human monocyte-derived dendritic cell (DC) maturation and cytokine production. DC maturation markers CD80, CD86 and CD83 were readily upregulated by H37Ra- and H37Rv-associated antigens, the 30-kDa (from Ag85 B complex) and 38-KDa Mtb antigens only partially induced these markers. All Mtb antigens induced variable levels of IL-6 and low levels of IL-10, there was no release of IL-12p70 detectable. Substantial IL-12p40 production was restricted to LPS or H37Ra and H37Rv preparations. Although the proliferation levels of primary T cell responses were comparable using all the differentially stimulated DC, the 30-kDa and 38-kDa antigens showed a bias towards IL-4 secretion of polarized CD4+ T cells after secondary stimulation as compared to H37Ra and H37Rv preparations. Conclusion Together our data indicate that 30-kDa and 38-kDa Mtb antigens induced only partial DC maturation shifting immune responses towards a Th2 profile. PMID:24089996

2013-01-01

483

Late Holocene multi-proxy records of environmental change on the South Atlantic island Tristan da Cunha  

Microsoft Academic Search

Sediment stratigraphies from three sites, one lake, one overgrown lake, and an exposed section, on the island Tristan da Cunha in the temperate South Atlantic were analysed by means of pollen analysis, total carbon, nitrogen and sulphur content determination, magnetic susceptibility measurements and detailed radiocarbon dating. The aim of these studies was to reconstruct the late Holocene vegetation and climatic

Karl Ljung; Svante Björck; Dan Hammarlund; Lena Barnekow

2006-01-01

484

Isolation of a 19-kDa mycobacterium, bovis-specific antigen, different from MPB70/80, by chromatofocusing.  

PubMed

Two antigens, 19-kDa each, were purified from Mycobacterium bovis culture filtrate protein extract by chromatofocusing. Antigen I had a 4.5 pI, and its amino terminal (DPVDAVINTTCNYGQVVAALNATDP) showed a 100% homology with the hypothetical protein Rv1174c. Antigen II had a pI of 6.0 pI and its amino terminal (GDLVGPGCAEYAAANPTGPASVQGM) showed a 100% homology with M. bovis MPB70/80. Antigen I is a hetero-dimer formed by a glycosylated, 10.5-kDa, monomer and a non-glycosylated 8-kDa monomer with identical amino terminal sequences. Both antigens were recognized by the sera of PPD+ animals, but antigen I did not crossreact with sera of human PPD+ individuals. Antigen I was a weak inducer of lymphocyte proliferation and IFN-gamma production. Our results show that M. bovis expresses a 19 kDa glycoprotein, homologue to the product of M. tuberculosis gen Rv1174c, which may prove useful for bovine TB diagnostic assays. PMID:12455826

Varela, Elvira; Massó, Felipe; Páez, Araceli; Zenteno, Roberto; Zenteno, Edgar; Montaño, Luis F

2002-11-01

485

BLUEBERRY EXTRACT INHIBITS DA-OR AB-INDUCED DECREMENTS IN CALCIUM FLUX IN PRIMARY HIPPOCAMPAL CELLS  

Technology Transfer Automated Retrieval System (TEKTRAN)

Previously, we have shown that when exposed to dopamine (DA) or amyloid beta (A') COS-7 cells transfected with muscarinic receptor (MAChR) subtypes (M1, M2, or M4) lose their ability to buffer or extrude calcium following oxotremorine-induced depolarization. However, pre-treatment of these cells wit...

486

O PARADIGMA DO RESSUPRIMENTO ENXUTO: ARMADILHA NA GESTÃO DO FLUXO DE MATERIAIS ENTRE ELOS DA CADEIA DE SUPRIMENTOS  

Microsoft Academic Search

Este artigo apresenta um estudo de caso conduzido numa empresa do ramo industrial, na qual a lógica do ressuprimento de materiais entre seu Centro de Distribuição e suas filiais comerciais era fortemente influenciada não apenas por metas de redução dos níveis de estoque, mas também pela percepção que o ressuprimento enxuto (Just in Time) é o estado da prática a

Peter Wanke; Paulo Fernando Fleury

487

Neotropical Primates 11(2), August 200394 Machado, A. B. M., Fonseca, G. A. B. da, Machado, R. B.,  

E-print Network

Neotropical Primates 11(2), August 200394 Machado, A. B. M., Fonseca, G. A. B. da, Machado, R. B, João Pessoa, Paraíba. Milton, K. e May, M. 1976. Body weight, diet and home range area in primates) from an established group, and the foundation of a new group. Neotrop. Primates 4(1): 19-21. Myers, N

Norconk, Marilyn A.

488

CONCURSO PBLICO PARA PROVIMENTO DE VAGAS EM CARGOS DE ASSISTENTES DE PESQUISA DA CARREIRA DE PESQUISA -Edital 01/2014  

E-print Network

PQ2 ARIANE FRASSONI DOS SANTOS DE MATTOS 1214 PQ2 DEMERVAL SOARES MOREIRA 1162 PQ2 ENVER MANUEL ZELL DE MATTOS 1033 PQ3 LUIZ FERNANDO SAPUCCI 1059 PQ3 MARIA CRISTINA LEMOS DA SILVA 1378 PQ3 NICOLAS 1303 PQ5 DIEGO PEREIRA ENORE 1159 PQ5 ENRIQUE VIEIRA MATTOS 1404 PQ5 EVALDO SILVA 1370 PQ5 FLAVIA

489

Desenvolvimento Computacional para Observaes Astronmicas Remotas Ana Lcia da Silva Beraldo1, Andr de Castro Milone2  

E-print Network

Desenvolvimento Computacional para Observações Astronômicas Remotas Ana Lúcia da Silva Beraldo1 executada tanto em ambiente Linux como Windows. Atualmente, o Sistema está sendo aprimorado por Ana Lúcia e velocidade do vento. Luneta Meade DSI Pro (campo 3,8º x 2,7º). Focalizador automatizado. T

490

Pacui Virus, Rio Preto da Eva Virus, and Tapirape Virus, Three Distinct Viruses within the Family Bunyaviridae  

PubMed Central

Nearly complete genome sequences for three ungrouped viruses, Pacui virus (BEAN27326), Rio Preto da Eva virus (BEAR540870), and Tapirape virus (BEAN767592) isolated in the Amazon region are reported here. All three genomic segments (small, medium and large RNA) were recovered and were similar to members of the genus Orthobunyavirus. PMID:25395627

Medeiros, Daniele Barbosa de Almeida; Rodrigues, Sueli Guerreiro; Martins, Livia Caricio; de Lima, Clayton Pereira Silva; de Oliveira, Layanna Freitas; de Vasconcelos, Janaina Mota; Da Silva, Daisy Elaine; Cardoso, Jedson Ferreira; da Silva, Sandro Patroca; Vianez-Júnior, João Lídio da Silva Gonçalves; Vasconcelos, Pedro Fernando da Costa

2014-01-01

491

The mass and luminosity functions and the formation rate of DA white dwarfs in the Sloan Digital Sky Survey  

E-print Network

The SDSS Data Release 1 includes 1833 DA white dwarfs (WDs) and forms the largest homogeneous sample of WDs. This sample provides the best opportunity to study the statistical properties of WDs. We adopt a recently established theoretical model to calculate the mass and distance of each WD using the observational data. Then we adopt a bin-correction method to correct for selection effects and use the 1/V weight-factor method to calculate the luminosity function, the continuous mass function and the formation rate of these WDs. The SDSS DA WD sample is incomplete and suffers seriously from selection effects. After corrections for the selection effects, only 531 WDs remain. From this final sample we derive the most up-to-date luminosity function and mass function, in which we find a broad peak of WD masses centered around 0.58$M_{\\odot}$. The DA WD space density is calculated as $8.81\\times10^{-5}pc^{-3}$ and the formation rate is $2.579\\times 10^{-13}pc^{-3}yr^{-1}$. The statistical properties of the SDSS DA WD sample are generally in good agreement with previous observational and theoretical studies, and provide us information on the formation and evolution of WDs. However, a larger and more complete all-sky WD sample is still needed to explain some subtle disagreements and unresolved issues.

Qi Hu; Chaolun Wu; Xue-Bing Wu

2007-02-05

492

Fruita da Vida - A Revolutionary Method of Sizing and Design for Women's Pret-a-Porter Clothing  

Microsoft Academic Search

Fruit da Vida is a revolutionary method of clothing design that focuses on fitting and accentuating the true female form. Fruita realizes women's frustrations in locating ready-to-wear clothing that fits their shape. Presents a method of sizing based on body \\

2004-01-01

493

Educating in the Design and Construction of Built Environments Accessible to Disabled People: The Leonardo da Vinci AWARD Project  

ERIC Educational Resources Information Center

An interdisciplinary partnership within an European Leonardo da Vinci project has developed a new approach aimed at educating secondary school students in the creation of built environments accessible to disabled people and at sensitizing them towards the inclusion of people with disabilities in all realms of social life. The AWARD (Accessible…

Frattari, Antonio; Dalpra, Michela; Bernardi, Fabio

2013-01-01

494

Virtual Mobility in Reality: A Study of the Use of ICT in Finnish Leonardo da Vinci Mobility Projects.  

ERIC Educational Resources Information Center

An e-mail survey and interviews collected data on use of information and communications technology (ICT) in Finnish Leonardo da Vinci mobility projects from 2000-02. Findings showed that the most common ICT tools used were e-mail, digital tools, and the World Wide Web; ICT was used during all project phases; the most common problems concerned…

Valjus, Sonja

495

ANEXO DA RESOLUO NORMATIVA N. 19/CUn/2012. TERMO DE ADESO N. ________/____/UFSC/20___ AO PROGRAMA DE SERVIO  

E-print Network

, com sede no Campus Universitário, Trindade, Florianópolis, Estado de Santa Catarina, Brasil, inscrita.2. ___________________________________________________ (Voluntário - nome, nacionalidade, profissão, RG, CPF, DATA DE NASCIMENTO, endereço residencial). 2. DA

Floeter, Sergio Ricardo

496

EDITAL N 65/2012 Processo Seletivo do Curso de Ps-Graduao Lato Sensu em Gesto da Sade,  

E-print Network

destinadas ao curso em conformidade com o ­ UAB/CAPES/MEC ­ Sistema Universidade Aberta do Brasil. 1. DOS; - Carteira de Identidade; - CPF; - Título de Eleitor e comprovante de votação da última eleição; - Certidão

Paraná, Universidade Federal do

497

FELDSPATHIC CLASTS IN POLYMICT UREILITE DaG 319: THE PROBLEM OF PRISTINITY. B. A. Cohen and C. A.  

E-print Network

FELDSPATHIC CLASTS IN POLYMICT UREILITE DaG 319: THE PROBLEM OF PRISTINITY. B. A. Cohen and C. A collection. However, feldspathic clasts that may represent ureilitic basalts occur in polymict ureilites [1. [7] Wilson and Keil (1991) EPSL 104, 505. [8] Goodrich and Cohen (2002) this volume. 65th Annual

Cohen, Barbara Anne

498

ESTUDO DE UMA OPERADORA LOGÍSTICA DA CADEIA DO FRIO SITUADA NO NORDESTE BRASILEIRO: O CASO TRU-LOGÍSTICA  

Microsoft Academic Search

A globalização impôs à grande maioria dos mercados, níveis de especialização focados na eficiência como condição indispensável para sobrevivência. O surgimento desse novo cenário trouxe em seu arcabouço a necessidade de sinergia entre todas as áreas existentes na empresa. As áreas de marketing precisavam estar inteiradas da capacidade de vendas no respectivo departamento, que por sua vez, precisavam ter conhecimento

Fabio De Oliveira Medeiros; Luiz Andrea Favero; Lucinaldo De Sousa E Silva; Rejane Andrea Deiga Ferreira

2008-01-01

499

SHEEP OESOPHAGEAL REACTIONS DURING ERUCTATION D.H. CARR P.C. SCOTT D.A. TITCHEN2  

E-print Network

SHEEP OESOPHAGEAL REACTIONS DURING ERUCTATION D.H. CARR P.C. SCOTT D.A. TITCHEN2 Department of the gut there have been numerous applications of the technique. In recent studies in the sheep e. Material and Methods Six Australian merino sheep about 1 year old were the experimental subjects. The care

Boyer, Edmond

500

Workflow-Driven Ontologies: An Earth Sciences Case Study Leonardo Salayandia, Paulo Pinheiro da Silva, Ann Q. Gates, Flor Salcedo  

E-print Network

Workflow-Driven Ontologies: An Earth Sciences Case Study Leonardo Salayandia, Paulo Pinheiro da is conducted. The earth sciences community has begun the complex task of creating ontologies to support of computer science and earth science disciplines [1]. GEON is comprised of computation clusters that include

Ward, Karen