Sample records for vector-mediated presumed dog

  1. [Malassezia and its presumed association with skin diseases in dogs].

    PubMed

    Nagata, Masahiko

    2013-01-01

    Malassezia pachydermatis is the major species in Malassezia isolated from dogs, and there is a presumably Malassezia-associated skin disease,"Malassezia dermatitis" in the dog. The skin lesion is characterized by relatively demarcated erythema with some scaling at the sebum-rich areas, in which lichenification and hyperpigmentation could be involved in the chronic stage. The clinical features suggest that it corresponds to seborrheic dermatitis in humans. Hence, it might be possible to identify essential pathogenesis of the disease by clarifying its differences in humans and animals as a shared disease. PMID:23470954

  2. Unusual congenital pulmonary anomaly with presumed left lung hypoplasia in a young dog.

    PubMed

    Lee, C M; Kim, J H; Kang, M H; Eom, K D; Park, H M

    2014-05-01

    A seven-month-old, entire, male miniature schnauzer dog was referred with acute vomiting, inappetence and depression primarily as a result of a gastric foreign body (pine cones). During investigations, thoracic radiographs revealed increased volume of the right lung lobes, deviated cardiomediastinal structures and elevation of the heart from the sternum. Thoracic computed tomography revealed left cranial lung lobe hypoplasia and extension of the right cranial lung parenchyma across the midline to the left hemithorax. Branches of the right pulmonary vessels and bronchi also crossed the midline and extended to the left caudal lung lobe. These findings suggested that the right and left lungs were fused. In humans this finding is consistent with horseshoe lung, which is an uncommon congenital malformation. To the authors' knowledge, this case represents the first report of such a pulmonary anomaly in a dog. PMID:24628409

  3. Vector-mediated antibody gene transfer for infectious diseases.

    PubMed

    Schnepp, Bruce C; Johnson, Philip R

    2015-01-01

    This chapter discusses the emerging field of vector-mediated antibody gene transfer as an alternative vaccine for infectious disease, with a specific focus on HIV. However, this methodology need not be confined to HIV-1; the general strategy of vector-mediated antibody gene transfer can be applied to other difficult vaccine targets like hepatitis C virus, malaria, respiratory syncytial virus, and tuberculosis. This approach is an improvement over classical passive immunization strategies that administer antibody proteins to the host to provide protection from infection. With vector-mediated gene transfer, the antibody gene is delivered to the host, via a recombinant adeno-associated virus (rAAV) vector; this in turn results in long-term endogenous antibody expression from the injected muscle that confers protective immunity. Vector-mediated antibody gene transfer can rapidly move existing, potent broadly cross-neutralizing HIV-1-specific antibodies into the clinic. The gene transfer products demonstrate a potency and breadth identical to the original product. This strategy eliminates the need for immunogen design and interaction with the adaptive immune system to generate protection, a strategy that so far has shown limited promise. PMID:25757620

  4. Long-Term Follow-up of Foamy Viral Vector-Mediated Gene Therapy for Canine Leukocyte Adhesion Deficiency

    PubMed Central

    Bauer, Thomas R; Tuschong, Laura M; Calvo, Katherine R; Shive, Heather R; Burkholder, Tanya H; Karlsson, Eleanor K; West, Robert R; Russell, David W; Hickstein, Dennis D

    2013-01-01

    The development of leukemia following gammaretroviral vector-mediated gene therapy for X-linked severe combined immunodeficiency disease and chronic granulomatous disease (CGD) has emphasized the need for long-term follow-up in animals treated with hematopoietic stem cell gene therapy. In this study, we report the long-term follow-up (4–7 years) of four dogs with canine leukocyte adhesion deficiency (CLAD) treated with foamy viral (FV) vector-mediated gene therapy. All four CLAD dogs previously received nonmyeloablative conditioning with 200 cGy total body irradiation followed by infusion of autologous, CD34+ hematopoietic stem cells transduced by a FV vector expressing canine CD18 from an internal Murine Stem Cell Virus (MSCV) promoter. CD18+ leukocyte levels were >2% following infusion of vector-transduced cells leading to ongoing reversal of the CLAD phenotype for >4 years. There was no clinical development of lymphoid or myeloid leukemia in any of the four dogs and integration site analysis did not reveal insertional oncogenesis. These results showing disease correction/amelioration of disease in CLAD without significant adverse events provide support for the use of a FV vector to treat children with leukocyte adhesion deficiency type 1 (LAD-1) in a human gene therapy clinical trial. PMID:23531552

  5. Computational model of a vector-mediated epidemic

    NASA Astrophysics Data System (ADS)

    Dickman, Adriana Gomes; Dickman, Ronald

    2015-05-01

    We discuss a lattice model of vector-mediated transmission of a disease to illustrate how simulations can be applied in epidemiology. The population consists of two species, human hosts and vectors, which contract the disease from one another. Hosts are sedentary, while vectors (mosquitoes) diffuse in space. Examples of such diseases are malaria, dengue fever, and Pierce's disease in vineyards. The model exhibits a phase transition between an absorbing (infection free) phase and an active one as parameters such as infection rates and vector density are varied.

  6. HSV vector-mediated modification of primary nociceptor afferents: an approach to inhibit chronic pain

    Microsoft Academic Search

    J R Goss; M S Gold; J C Glorioso

    2009-01-01

    Chronic pain is a serious medical condition with millions of sufferers for whom long-term therapies are either lacking or inadequate. Here we review the use of herpes simplex virus vectors as therapeutic tools to treat chronic pain by gene therapy. We describe an approach to inhibit chronic pain signaling whereby vector-mediated genes transferred to sensory nerves will modify the primary

  7. Lentiviral Vector Mediated Claudin1 Silencing Inhibits Epithelial to Mesenchymal Transition in Breast Cancer Cells

    PubMed Central

    Zhao, Xianqi; Zou, Yanan; Gu, Qingqing; Zhao, Guannan; Gray, Horace; Pfeffer, Lawrence M.; Yue, Junming

    2015-01-01

    Breast cancer has a high incidence and mortality rate worldwide. Several viral vectors including lentiviral, adenoviral and adeno-associated viral vectors have been used in gene therapy for various forms of human cancer, and have shown promising effects in controlling tumor development. Claudin1 (CLDN1) is a member of the tetraspan transmembrane protein family that plays a major role in tight junctions and is associated with tumor metastasis. However, the role of CLDN1 in breast cancer is largely unexplored. In this study, we tested the therapeutic potential of silencing CLDN1 expression in two breast cancer (MDA-MB-231 and MCF7) cell lines using lentiviral vector mediated RNA interference. We found that a CLDN1 short hairpin (shRNA) construct efficiently silenced CLDN1 expression in both breast cancer cell lines, and CLDN1 knockdown resulted in reduced cell proliferation, survival, migration and invasion. Furthermore, silencing CLDN1 inhibited epithelial to mesenchymal transition (EMT) by upregulating the epithelial cell marker, E-cadherin, and downregulating mesenchymal markers, smooth muscle cell alpha-actin (SMA) and Snai2. Our data demonstrated that lentiviral vector mediated CLDN1 RNA interference has great potential in breast cancer gene therapy by inhibiting EMT and controlling tumor cell growth. PMID:26067567

  8. Lentiviral Vector-Mediated RNA Silencing in the Central Nervous System

    PubMed Central

    Foster, Edmund; Moon, Lawrence D.F.

    2014-01-01

    Abstract RNA silencing is an established method for investigating gene function and has attracted particular interest because of the potential for generating RNA-based therapeutics. Using lentiviral vectors as an efficient delivery system that offers stable, long-term expression in postmitotic cells further enhances the applicability of an RNA-based gene therapy for the CNS. In this review we provide an overview of both lentiviral vectors and RNA silencing along with design considerations for generating lentiviral vectors capable of RNA silencing. We go on to describe the current preclinical data regarding lentiviral vector-mediated RNA silencing for CNS disorders and discuss the concerns of side effects associated with lentiviral vectors and small interfering RNAs and how these might be mitigated. PMID:24090197

  9. Baculovirus vector-mediated transfer of NIS gene into colon tumor cells for radionuclide therapy

    PubMed Central

    Yin, Hong-Yan; Zhou, Xiang; Wu, Hai-Fei; Li, Biao; Zhang, Yi-Fan

    2010-01-01

    AIM: To investigate the feasibility of radionuclide therapy of colon tumor cells by baculovirus vector-mediated transfer of the sodium/iodide symporter (NIS) gene. METHODS: A recombinant baculovirus plasmid carrying the NIS gene was constructed, and the viruses (Bac-NIS) were prepared using the Bac-to-Bac system. The infection efficiency in the colon cancer cell line SW1116 of a green fluorescent protein (GFP) expressing baculovirus (Bac-GFP) at different multiplicities of infection (MOI) with various concentrations of sodium butyrate was determined by flow cytometry. An in vitro cytotoxicity assay was also conducted after infection of SW1116 cells with Bac-NIS. Iodine uptake of Bac-NIS infected SW1116 cells and inhibition of this uptake by sodium perchlorate was examined, and the effect of Bac-NIS-mediated 131I in killing tumor cells was evaluated by cell colony formation tests. RESULTS: Infection and transgene expression in SW1116 with Bac-GFP were significantly enhanced by sodium butyrate, as up to 72% of SW1116 cells were infected with the virus at MOI of 400 and sodium butyrate at 0.5 mmol/L. No obvious cytotoxicity was observed under these conditions. Infection of SW1116 with Bac-NIS allowed uptake of 131I in these tumor cells, which could be inhibited by sodium perchlorate. The viability of SW1116 cells infected with Bac-NIS was significantly lower than with Bac-GFP, suggesting that NIS gene-mediated 131I uptake could specifically kill tumor cells. CONCLUSION: Baculovirus vector-mediated NIS gene therapy is a potential approach for treatment of colon cancer. PMID:21072902

  10. Effects of Herpes Simplex Virus Vector–Mediated Enkephalin Gene Therapy on Bladder Overactivity and Nociception

    PubMed Central

    Yokoyama, Hitoshi; Oguchi, Tomohiko; Goins, William F.; Goss, James R.; Nishizawa, Osamu; de Groat, William C.; Wolfe, Darren; Krisky, David M.; Glorioso, Joseph C.

    2013-01-01

    Abstract We previously reported the effects of herpes simplex virus (HSV) vector–mediated enkephalin on bladder overactivity and pain. In this study, we evaluated the effects of vHPPE (E1G6-ENK), a newly engineered replication-deficient HSV vector encoding human preproenkephalin (hPPE). vHPPE or control vector was injected into the bladder wall of female rats 2 weeks prior to the following studies. A reverse-transcription PCR study showed high hPPE transgene levels in L6 dorsal root ganglia innervating the bladder in the vHPPE group. The number of freezing behaviors, which is a nociceptive reaction associated with bladder pain, was also significantly lower in the vHPPE group compared with the control group. The number of L6 spinal cord c-fos–positive cells and the urinary interleukin (IL)-1? and IL-6 levels after resiniferatoxin (RTx) administration into the bladder of the vHPPE group were significantly lower compared with those of the control vector–injected group. In continuous cystometry, the vHPPE group showed a smaller reduction in intercontraction interval after RTx administration into the bladder. This antinociceptive effect was antagonized by naloxone hydrochloride. Thus, the HSV vector vHPPE encoding hPPE demonstrated physiological improvement in visceral pain induced by bladder irritation. Gene therapy may represent a potentially useful treatment modality for bladder hypersensitive disorders such as bladder pain syndrome/interstitial cystitis. PMID:23316929

  11. [Dog bites].

    PubMed

    Horn, Benedikt

    2015-01-01

    In Switzerland 10'000 people are bitten by a dog annualy. Dog bites are notifiable incidents. Defensive and offensive aggression of dogs (why does a dog bite?), history, signs, treatment and prevention are discussed. Finally a short psychogram of dog owner and victim emphasizes the role of avoiding any escalation. PMID:25533260

  12. Presumed glial retinal hamartomas in Usher's syndrome.

    PubMed

    Awan, K J

    1976-07-01

    The presence of glial hamartomas of the retina and the optic disc in retinitis pigmentosa is discussed. This association is described in a 26 year old white male with Usher's syndrome who had at the posterior pole of each eye a mass which closely resembled the mulberry-like lesions of tuberose sclerosis. Several fine blood vessels were seen on the surface of these masses. The significance of the association of these presumed hamartomas with retinitis pigmentosa is not clear. They might be the result of a focal reactive hyperplasia of the glial cells of the retina. PMID:949638

  13. 27 CFR 70.52 - Signature presumed authentic.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ...and Firearms 2 2010-04-01 2010-04-01 false Signature presumed authentic. 70.52 Section 70.52 Alcohol...Occupational) Tax Collection-General Provisions § 70.52 Signature presumed authentic. An individual's name signed...

  14. 27 CFR 70.52 - Signature presumed authentic.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ...and Firearms 2 2011-04-01 2011-04-01 false Signature presumed authentic. 70.52 Section 70.52 Alcohol...Occupational) Tax Collection-General Provisions § 70.52 Signature presumed authentic. An individual's name signed...

  15. 27 CFR 70.52 - Signature presumed authentic.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ...and Firearms 2 2014-04-01 2014-04-01 false Signature presumed authentic. 70.52 Section 70.52 Alcohol...Occupational) Tax Collection-General Provisions § 70.52 Signature presumed authentic. An individual's name signed...

  16. 27 CFR 70.52 - Signature presumed authentic.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ...and Firearms 2 2013-04-01 2013-04-01 false Signature presumed authentic. 70.52 Section 70.52 Alcohol...Occupational) Tax Collection-General Provisions § 70.52 Signature presumed authentic. An individual's name signed...

  17. 27 CFR 70.52 - Signature presumed authentic.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ...and Firearms 2 2012-04-01 2011-04-01 true Signature presumed authentic. 70.52 Section 70.52 Alcohol...Occupational) Tax Collection-General Provisions § 70.52 Signature presumed authentic. An individual's name signed...

  18. [Surgical treatments of presumed benign ovarian tumors].

    PubMed

    Borghese, B; Marzouk, P; Santulli, P; de Ziegler, D; Chapron, C

    2013-12-01

    The surgical management of presumed benign ovarian tumors (PBOT) must ensure complete removal of the cyst, reduce the risk of recurrence (especially in case of endometrioma), prevent any risk of tumor dissemination, and must preserve healthy ovarian tissue. Asymptomatic PBOT should not be punctured. Expectation is preferable to puncture. Laparoscopy is the gold standard for surgical treatment. Single-port laparoscopy is feasible and being evaluated. Peritoneal exploration and peritoneal cytology are conventionally performed. Ovarian cystectomy, oophorectomy and salpingo-oophorectomy are the standard techniques. Suture after cystectomy is not recommended. The extraction of the cyst using an endoscopic bag is recommended. Peritoneal washing after surgery is recommended. The use of anti-adhesions barriers is not recommended routinely. In case of dermoid cyst, cystectomy by mesial incision may decrease the risk of intraoperative rupture. In case of endometrioma, the intraperitoneal cystectomy is recommended as first-line surgery. Exclusive bipolar coagulation should be avoided because of increased risk of recurrence and lower pregnancy rates. There is no argument to support the use of plasma energy and CO2 laser in the treatment of endometriomas. Ethanol sclerotherapy may be proposed in patients with recurrent endometriomas after surgery and referred to medically assisted procreation, although there is no comparative trial with cystectomy. PMID:24210231

  19. Restoration of normal lysosomal function in mucopolysaccharidosis type VII cells by retroviral vector-mediated gene transfer.

    PubMed Central

    Wolfe, J H; Schuchman, E H; Stramm, L E; Concaugh, E A; Haskins, M E; Aguirre, G D; Patterson, D F; Desnick, R J; Gilboa, E

    1990-01-01

    Retroviral vectors were constructed containing a rat beta-glucuronidase cDNA driven by heterologous promoters. Vector-mediated gene transfer into human and canine beta-glucuronidase-deficient mucopolysaccharidosis type VII fibroblasts completely corrected the deficiency in beta-glucuronidase enzymatic activity. In primary cultures of canine mucopolysaccharidosis type VII retinal pigment epithelial cells, which contain large amounts of undegraded glycosaminoglycan substrates, vector correction restored normal processing of specific glycosaminoglycans in the lysosomal compartment. In canine mucopolysaccharidosis type VII bone marrow cells, beta-glucuronidase was expressed at high levels in transduced cells. Thus, the vector-encoded beta-glucuronidase was expressed at therapeutic levels in the appropriate organelle and corrected the metabolic defect in cells exhibiting the characteristic pathology of this lysosomal storage disorder. Images PMID:2158095

  20. The use of retroviral vectors for gene therapy-what are the risks? A review of retroviral pathogenesis and its relevance to retroviral vector-mediated gene delivery

    Microsoft Academic Search

    Donald S Anson

    2004-01-01

    Retroviral vector-mediated gene transfer has been central to the development of gene therapy. Retroviruses have several distinct advantages over other vectors, especially when permanent gene transfer is the preferred outcome. The most important advantage that retroviral vectors offer is their ability to transform their single stranded RNA genome into a double stranded DNA molecule that stably integrates into the target

  1. Dogs and Preventing Dog Bites

    MedlinePLUS

    ... just the way it should — with happy kids, happy dogs, and no dog bites! Reviewed by: Yamini Durani, MD Date reviewed: May 2015 Back 1 ? 2 ? 3 For Teens For Kids For Parents MORE ON THIS TOPIC Staying Safe Around Animals Dog Videos My Pet Died - How Can I Feel Better? ...

  2. DogsDogsDogsDogsDogsDogs Purdue University Cooperative Extension Service West Lafayette IN, 47907

    E-print Network

    Extension Service, West Lafayette, IN 47907 Animal Sciences AS-562-W Benefits of Castration in Male DogsBenefits of Castration in Male Dogs J. Belen and C.M. Brady, Purdue Department of Animal SciencesJ. Belen and C.M. Brady commonly known as castration (Johnston, 1991). This surgery is generally performed in male dogs for three

  3. 26 CFR 301.6064-1 - Signature presumed authentic.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ...Internal Revenue 18 2013-04-01 2013-04-01 false Signature presumed authentic. 301.6064-1 Section 301.6064-1...Information and Returns Returns and Records § 301.6064-1 Signature presumed authentic. An individual's name signed to...

  4. 26 CFR 301.6064-1 - Signature presumed authentic.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ...Internal Revenue 18 2010-04-01 2010-04-01 false Signature presumed authentic. 301.6064-1 Section 301.6064-1...Information and Returns Returns and Records § 301.6064-1 Signature presumed authentic. An individual's name signed to...

  5. 26 CFR 301.6064-1 - Signature presumed authentic.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ...Internal Revenue 18 2012-04-01 2012-04-01 false Signature presumed authentic. 301.6064-1 Section 301.6064-1...Information and Returns Returns and Records § 301.6064-1 Signature presumed authentic. An individual's name signed to...

  6. 26 CFR 301.6064-1 - Signature presumed authentic.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ...Internal Revenue 18 2014-04-01 2014-04-01 false Signature presumed authentic. 301.6064-1 Section 301.6064-1...Information and Returns Returns and Records § 301.6064-1 Signature presumed authentic. An individual's name signed to...

  7. 26 CFR 301.6064-1 - Signature presumed authentic.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ...Internal Revenue 18 2011-04-01 2011-04-01 false Signature presumed authentic. 301.6064-1 Section 301.6064-1...Information and Returns Returns and Records § 301.6064-1 Signature presumed authentic. An individual's name signed to...

  8. 20 CFR 219.24 - Evidence of presumed death.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ...2010-04-01 false Evidence of presumed death. 219.24 Section 219.24 Employees...EVIDENCE REQUIRED FOR PAYMENT Evidence of Age and Death § 219.24 Evidence of presumed death. When a person cannot be proven dead but...

  9. 20 CFR 219.24 - Evidence of presumed death.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 2012-04-01 true Evidence of presumed death. 219.24 Section 219.24 Employees...EVIDENCE REQUIRED FOR PAYMENT Evidence of Age and Death § 219.24 Evidence of presumed death. When a person cannot be proven dead but...

  10. 20 CFR 219.24 - Evidence of presumed death.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ...2011-04-01 false Evidence of presumed death. 219.24 Section 219.24 Employees...EVIDENCE REQUIRED FOR PAYMENT Evidence of Age and Death § 219.24 Evidence of presumed death. When a person cannot be proven dead but...

  11. 20 CFR 219.24 - Evidence of presumed death.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ...2012-04-01 false Evidence of presumed death. 219.24 Section 219.24 Employees...EVIDENCE REQUIRED FOR PAYMENT Evidence of Age and Death § 219.24 Evidence of presumed death. When a person cannot be proven dead but...

  12. 20 CFR 219.24 - Evidence of presumed death.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 2012-04-01 true Evidence of presumed death. 219.24 Section 219.24 Employees...EVIDENCE REQUIRED FOR PAYMENT Evidence of Age and Death § 219.24 Evidence of presumed death. When a person cannot be proven dead but...

  13. Transient blocking of NK cell function with small molecule inhibitors for helper dependant adenoviral vector-mediated gene delivery.

    PubMed

    Ankathatti Munegowda, Manjunatha; Hu, Jim

    2015-01-01

    One major challenge in gene therapy is the host immune responses against viral vectors. Previous studies indicate the involvement of NK cells in stunted gene expression in viral vector mediated gene therapy. To understand the problem of the immune responses, we have developed an in-vitro co-culture system with human NK cell line, macrophages and airway epithelial cells. We showed that small molecule blockers, CAPE and ruxolitinib, for NF-?B and JAK-STAT pathways, respectively, significantly inhibited cytokine secretion by macrophages. When NK cells are co-cultured with helper-dependent adenoviral (HD-Ad) vector activated macrophages, IFN-? cytokine expression by NK cells increased significantly, which was inhibited effectively by ruxolitinib and CAPE, and there was an additive effect when both inhibitors were used. We demonstrated that NK cells activated by cytokines produced by HD-Ad-activated macrophages kill HD-Ad vector transduced bronchial epithelial cells. This cell killing activity was significantly reduced by CAPE and ruxolitinib. Combination of these two inhibitors had an additive effect on inhibiting NK cell mediate killing of gene transduced cells. Transient inhibition of NK cell response at its peak may enhance sustained gene expression. Our data suggest that combination of CAPE and ruxolitinib may help in protecting gene transduced airway epithelial cells to prolong transgene expression. PMID:26085921

  14. Combined therapeutic effects of adenoviral vector-mediated GLIPR1 gene therapy and radiotherapy in prostate and bladder cancer models

    PubMed Central

    Fujita, Tetsuo; Satoh, Takefumi; Timme, Terry L.; Hirayama, Takahiro; Zhu, Julie X.; Kusaka, Nobuyuki; Naruishi, Koji; Yang, Guang; Goltsov, Alexei; Wang, Jianxiang; Vlachaki, Maria T; Teh, Bin S.; Butler, E. Brian; Thompson, Timothy C

    2013-01-01

    Objectives To explore the potential benefits of combining AdGlipr1 (or AdGLIPR1) gene therapy with radiotherapy using subcutaneous prostate and bladder cancer models. Materials and methods Combination adenoviral vector-mediated gene therapy and radiotherapy were applied to 178-2 BMA and TSU-Pr1 cells in vitro and colony formation and apoptosis were analyzed. Also, combination therapies were administered to mice bearing subcutaneous 178-2 BMA and TSU-Pr1 tumors and tumor growth suppression and survival extension were compared with the monotherapies (AdGlipr1/ AdGLIPR1, radiotherapy) or control vector Adv/CMV/?gal as well as comparing single cycle treatment with two cycle treatment. Results Combination treatment significantly suppressed colony formation and increased apoptosis in vitro. In vivo, combination therapy produced significant 178-2 BMA and TSU-Pr1 tumor growth suppression and survival extension compared with the monotherapies or the control. Further tumor growth suppression and survival extension were observed after two cycles of the combination treatment. Conclusions Combining AdGlipr1 (AdGLIPR1) with radiotherapy may achieve additive or synergistic tumor control in selected prostate and bladder tumors, and additional therapeutic effects may result with repeated treatment cycle. PMID:23433894

  15. Vector-Mediated Delivery of a Polyamide ("Peptide") Nucleic Acid Analogue through the Blood-Brain Barrier in vivo

    NASA Astrophysics Data System (ADS)

    Pardridge, William M.; Boado, Ruben J.; Kang, Young-Sook

    1995-06-01

    Polyamide ("peptide") nucleic acids (PNAs) are molecules with antigene and antisense effects that may prove to be effective neuropharmaceuticals if these molecules are enabled to undergo transport through the brain capillary endothelial wall, which makes up the blood-brain barrier in vivo. The model PNA used in the present studies is an 18-mer that is antisense to the rev gene of human immunodeficiency virus type 1 and is biotinylated at the amino terminus and iodinated at a tyrosine residue near the carboxyl terminus. The biotinylated PNA was linked to a conjugate of streptavidin (SA) and the OX26 murine monoclonal antibody to the rat transferrin receptor. The blood-brain barrier is endowed with high transferrin receptor concentrations, enabling the OX26-SA conjugate to deliver the biotinylated PNA to the brain. Although the brain uptake of the free PNA was negligible following intravenous administration, the brain uptake of the PNA was increased at least 28-fold when the PNA was bound to the OX26-SA vector. The brain uptake of the PNA bound to the OX26-SA vector was 0.1% of the injected dose per gram of brain at 60 min after an intravenous injection, approximating the brain uptake of intravenously injected morphine. The PNA bound to the OX26-SA vector retained the ability to bind to synthetic rev mRNA as shown by RNase protection assays. In summary, the present studies show that while the transport of PNAs across the blood-brain barrier is negligible, delivery of these potential neuropharmaceutical drugs to the brain may be achieved by coupling them to vector-mediated peptide-drug delivery systems.

  16. 10 CFR 436.13 - Presuming cost-effectiveness results.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ...If the investment and other costs for an energy or water conservation measure considered for retrofit to an existing...agency may presume that an investment in an energy or water conservation measure retrofit to an existing Federal...

  17. 10 CFR 436.13 - Presuming cost-effectiveness results.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ...If the investment and other costs for an energy or water conservation measure considered for retrofit to an existing...agency may presume that an investment in an energy or water conservation measure retrofit to an existing Federal...

  18. 10 CFR 436.13 - Presuming cost-effectiveness results.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ...If the investment and other costs for an energy or water conservation measure considered for retrofit to an existing...agency may presume that an investment in an energy or water conservation measure retrofit to an existing Federal...

  19. Presumed consent to organ donation in three European countries.

    PubMed

    Neades, Barbara L

    2009-05-01

    United Kingdom Transplant reported that, during 2007-2008, a total of 7655 people were awaiting a transplant; however, only 3235 organs were available via the current ;opt in' approach. To address this shortfall, new UK legislation sought to increase the number of organs available for donation. The Chief Medical Officer for England and Wales supports the adoption of ;presumed consent' legislation, that is, an ;opt out' approach, as used in much of Europe. Little research, however, has explored the impact on bereaved relatives, nurses and medical staff of introducing presumed consent legislation. Adopting a phenomenological approach, this study used responses to an initial questionnaire combined with selected interviews with health care professionals to capture their direct experience of presumed consent legislation in three European countries: Portugal, Norway and Belgium. PMID:19372122

  20. Dog Bite Prevention

    MedlinePLUS

    ... records. Consult with your veterinarian about your dog’s aggressive action. Your veterinarian can examine your dog to ... or one they know. Some owners actually promote aggression in their dogs or allow aggression to go ...

  1. Dog Whisperer

    E-print Network

    Hacker, Randi

    2013-05-22

    Broadcast Transcript: As we mentioned in an earlier Postcard, dogs have only recently become favored pets rather than favorite meals here in China. And, if you needed further proof of this transformation, here it is: Cesar Millan has been tapped...

  2. Dog Bites

    MedlinePLUS

    ... Address What's this? Submit What's this? Submit Button Dog Bites - This page has been removed Recommend on ... file RIS file Page last reviewed: February 5, 2015 Page last updated: February 5, 2015 Content source: ...

  3. Dog Tents 

    E-print Network

    Unknown

    2011-09-05

    EVALUATION OF THE RABIES IMMUNE STATUS OF STRAY DOGS IN BEAUMONT AND PORT ARTHUR, TEXAS A Thesis by JAMES LEONIDAS MASSEY, JR. Submitted to the Graduate College of Texas AN University in partial fulfillment of the requirement for the degree... of MASTER OF SCIENCE May 1981 Major Subject: Epidemiology EVALUATION OF THE RABIES IMMUNE STATUS OF STRAY DOGS IN BEAUMONT AND PORT ARTHUR, TEXAS A Thesis by JAMES LEONIDAS MASSEY, JR. Approved as to style and content by: Chairman of Committee Mem...

  4. UNSATISFACTORY STUDENTS PROCEDURE (including the Presumed Withdrawn Process)

    E-print Network

    Haase, Markus

    UNSATISFACTORY STUDENTS PROCEDURE (including the Presumed Withdrawn Process) The Unsatisfactory Students Procedure is applied to all taught students whose work, attendance or progress is unsatisfactory1 . It does not apply to serious examination failure, which is dealt with through the Referred Students

  5. 12. VIEW OF (PRESUMED) OUTHOUSE SHED. DOOR HAS AN AIR ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    12. VIEW OF (PRESUMED) OUTHOUSE SHED. DOOR HAS AN AIR FORCE INSIGNIA EMBLEM AFFIXED, 'AIR FORCE WEAPONS LABORATORY.' OTHER SIGN ON DOOR SAYS, 'BSD LIASON OFFICE.' INEL PHOTO NUMBER 65-6173, TAKEN NOVEMBER 10, 1965. - Idaho National Engineering Laboratory, Advanced Reentry Vehicle Fusing System, Scoville, Butte County, ID

  6. Renal clearance studies of effect of left atrial distension in the dog.

    NASA Technical Reports Server (NTRS)

    Kinney, M. J.; Discala, V. A.

    1972-01-01

    Investigation of the water diuresis of left atrial distension in 16 dogs on the basis of clearance studies employing hydration, chronic and acute salt loading, deoxycorticosterone (DOCA) in excess, and distal tubular nephron blockade with diuretics. The diuresis was found in hydrated and salt-loaded dogs and was independent of DOCA and presumed renin depletion. It was not found in five dogs after distal tubular blockade. No significant reproducible saluresis was ever documented. The water diuresis was always stopped by exogenous vasopressin (seven dogs). Antidiuretic hormone inhibition with distal tubular nephron water permeability changes appears to be the sole mechanism of the diuresis of left atrial distension in the dog.

  7. 28 CFR 104.45 - Determination of presumed economic loss for claimants who suffered physical harm.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ...2012-07-01 false Determination of presumed economic loss for claimants who suffered physical...104.45 Determination of presumed economic loss for claimants who suffered physical...In reaching presumed determinations for economic loss for claimants who suffered...

  8. 28 CFR 104.45 - Determination of presumed economic loss for claimants who suffered physical harm.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ...2011-07-01 false Determination of presumed economic loss for claimants who suffered physical...104.45 Determination of presumed economic loss for claimants who suffered physical...In reaching presumed determinations for economic loss for claimants who suffered...

  9. 28 CFR 104.45 - Determination of presumed economic loss for claimants who suffered physical harm.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ...2013-07-01 false Determination of presumed economic loss for claimants who suffered physical...104.45 Determination of presumed economic loss for claimants who suffered physical...In reaching presumed determinations for economic loss for claimants who suffered...

  10. Organ transplant and presumed consent: towards an "opting out" system.

    PubMed

    Kaushik, Jyotika

    2009-01-01

    This paper examines the "opt out" system of organ donation wherein the State permits removal of tissue and organs posthumously unless an express objection is made by the person prior to the death. This paper examines the need for "presumed consent" and the jurisprudential arguments in support of it. The social contract theory and the sociological approach based on the principle of "common good" support this system. However, the ethical concerns raised while implementing such a system are debatable. It is for societies to evaluate the situation and make a choice between "ethics"and "common good". The answer may not be obvious in a country like India where religion may supersede the question of life and death. The paper critically assesses both the issues, and concludes that presumed consent may be a viable method of addressing the organ shortage in India. However, we need public discourse and public awareness to change people's attitude to this concept. PMID:19653591

  11. Presumed Group B Streptococcal Meningitis After Epidural Blood Patch.

    PubMed

    Beilin, Yaakov; Spitzer, Yelena

    2015-06-15

    Bacterial meningitis after epidural catheter placement is rare. We describe a case in which a parturient received labor epidural analgesia for vaginal delivery complicated by dural puncture. The patient developed postdural puncture headache and underwent 2 separate epidural blood patch procedures. She subsequently developed a headache with fever and focal neurologic deficits. She was treated with broad spectrum antibiotics for presumed meningitis, and she made a full recovery. Blood cultures subsequently grew group B streptococcus. PMID:26050248

  12. Ask Dog Lady

    NSDL National Science Digital Library

    What to do with a problem dog? What is the best book on dog training? Would Tony Soprano benefit from owning a dog? How can you trust your dog walker with your dog? All these questions are addressed by the Dog Lady, who gives advice, as she says herself, on "dogs, love, and life." Always readable and often funny, the Dog Lady answers emails from viewers with questions about their canine pets. Users can read recent columns or review the "Best in Show" archive, a collection of the Dog Lady's most memorable advice. [CH

  13. Cloning Dogs

    E-print Network

    Hacker, Randi

    2009-03-08

    Broadcast Transcript: For those of you who have put off cloning your favorite pet due to the exorbitant cost, good news! The process just got cheaper. A biotech company here in South Korea has discovered that stems cells from the fat tissue in a dog...

  14. The use of retroviral vectors for gene therapy-what are the risks? A review of retroviral pathogenesis and its relevance to retroviral vector-mediated gene delivery

    PubMed Central

    Anson, Donald S

    2004-01-01

    Retroviral vector-mediated gene transfer has been central to the development of gene therapy. Retroviruses have several distinct advantages over other vectors, especially when permanent gene transfer is the preferred outcome. The most important advantage that retroviral vectors offer is their ability to transform their single stranded RNA genome into a double stranded DNA molecule that stably integrates into the target cell genome. This means that retroviral vectors can be used to permanently modify the host cell nuclear genome. Recently, retroviral vector-mediated gene transfer, as well as the broader gene therapy field, has been re-invigorated with the development of a new class of retroviral vectors which are derived from lentiviruses. These have the unique ability amongst retroviruses of being able to infect non-cycling cells. Vectors derived from lentiviruses have provided a quantum leap in technology and seemingly offer the means to achieve significant levels of gene transfer in vivo. The ability of retroviruses to integrate into the host cell chromosome also raises the possibility of insertional mutagenesis and oncogene activation. Both these phenomena are well known in the interactions of certain types of wild-type retroviruses with their hosts. However, until recently they had not been observed in replication defective retroviral vector-mediated gene transfer, either in animal models or in clinical trials. This has meant the potential disadvantages of retroviral mediated gene therapy have, until recently, been seen as largely, if not entirely, hypothetical. The recent clinical trial of ?c mediated gene therapy for X-linked severe combined immunodeficiency (X-SCID) has proven the potential of retroviral mediated gene transfer for the treatment of inherited metabolic disease. However, it has also illustrated the potential dangers involved, with 2 out of 10 patients developing T cell leukemia as a consequence of the treatment. A considered review of retroviral induced pathogenesis suggests these events were qualitatively, if not quantitatively, predictable. In addition, it is clear that the probability of such events can be greatly reduced by relatively simple vector modifications, such as the use of self-inactivating vectors and vectors derived from non-oncogenic retroviruses. However, these approaches remain to be fully developed and validated. This review also suggests that, in all likelihood, there are no other major retroviral pathogenetic mechanisms that are of general relevance to replication defective retroviral vectors. These are important conclusions as they suggest that, by careful design and engineering of retroviral vectors, we can continue to use this gene transfer technology with confidence. PMID:15310406

  15. Training dogs to detect Triacetone Triperoxide (TATP)

    NASA Astrophysics Data System (ADS)

    Oxley, Jimmie C.; Smith, James L.; Moran, Jesse; Nelson, Ken; Utley, William E.

    2004-09-01

    Dogs have been used successfully to detect drugs and conventional high explosives. The world-wide rise in terrorist activities has placed emphasis on the detection of non-conventional explosive materials such as the multi-functional peroxides, triacetone triperoxide (TATP) and hexamethylene triperoxide diamine (HMTD). This study demonstrates that dogs can detect both solid TATP and TATP adsorbed to cotton balls. An effective procedure to train dogs to detect TATP using cotton balls permeated with TATP vapor is provided. The various trials showed that dogs were capable of detecting as little as 200 ?g of TATP adsorbed to a one gram cotton ball under a variety of circumstances. However, since TATP vaporizes rapidly at room temperature, significant depletion of TATP from cotton balls can occur in as little as 20 minutes, hampering the ability of the dogs to detect it. The TATP depleted cotton ball can be refreshed by returning it to a sealed container with TATP residue for about 20 minutes. A presumed decomposition product of TATP, acetone, cannot be used in place of TATP to train dogs.

  16. Dramatic regression of presumed acquired retinal astrocytoma with photodynamic therapy.

    PubMed

    Tuncer, Samuray; Cebeci, Zafer

    2014-01-01

    Photodynamic therapy (PDT) has been used for treatment of various intraocular tumors including choroidal hemangioma, vasoproliferative tumor, amelanotic choroidal melanoma and choroidal neovascular membrane due to choroidal osteoma. This case report documents the effect of PDT for a presumed acquired retinal astrocytoma. A 42-year-old female with a juxtapapillary acquired astrocytoma was treated with a single session of PDT using standard parameters. The tumor showed dramatic regression over 6 months into a fibrotic scar. It remained regressed and stable with 20/20 vision after 51 months of follow-up. We believe that PDT can be used as a primary treatment for acquired retinal astrocytoma. PMID:25100919

  17. Dramatic Regression of Presumed Acquired Retinal Astrocytoma with Photodynamic Therapy

    PubMed Central

    Tuncer, Samuray; Cebeci, Zafer

    2014-01-01

    Photodynamic therapy (PDT) has been used for treatment of various intraocular tumors including choroidal hemangioma, vasoproliferative tumor, amelanotic choroidal melanoma and choroidal neovascular membrane due to choroidal osteoma. This case report documents the effect of PDT for a presumed acquired retinal astrocytoma. A 42-year-old female with a juxtapapillary acquired astrocytoma was treated with a single session of PDT using standard parameters. The tumor showed dramatic regression over 6 months into a fibrotic scar. It remained regressed and stable with 20/20 vision after 51 months of follow-up. We believe that PDT can be used as a primary treatment for acquired retinal astrocytoma. PMID:25100919

  18. PBS-Nova: Dogs And More Dogs

    NSDL National Science Digital Library

    This Nova website, designed to accompany a television Feature Program on the world of Dogs, asks "How and why did man's best friend evolve from wolves, and why are dogs so remarkably diverse today?" The site showcases a slide show on working dogs and an interactive matching game entitled, Dogs Around the World. Also included at this website are a Teacher's Guide, a Links and Books page, and an Inquiry Article about Dog diversity. Additionally, this site links to the TV program transcript and to a recent "washingtonpost.com discussion with biologist and dog expert Ray Coppinger."

  19. Presumed Symbolic Use of Diurnal Raptors by Neanderthals

    PubMed Central

    Morin, Eugčne; Laroulandie, Véronique

    2012-01-01

    In Africa and western Eurasia, occurrences of burials and utilized ocher fragments during the late Middle and early Late Pleistocene are often considered evidence for the emergence of symbolically-mediated behavior. Perhaps less controversial for the study of human cognitive evolution are finds of marine shell beads and complex designs on organic and mineral artifacts in early modern human (EMH) assemblages conservatively dated to ?100–60 kilo-years (ka) ago. Here we show that, in France, Neanderthals used skeletal parts of large diurnal raptors presumably for symbolic purposes at Combe-Grenal in a layer dated to marine isotope stage (MIS) 5b (?90 ka) and at Les Fieux in stratigraphic units dated to the early/middle phase of MIS 3 (60–40 ka). The presence of similar objects in other Middle Paleolithic contexts in France and Italy suggest that raptors were used as means of symbolic expression by Neanderthals in these regions. PMID:22403717

  20. KEEPING OURSELVES SAFE NEAR DOGS

    E-print Network

    Little, Tony

    KEEPING OURSELVES SAFE NEAR DOGS Kendal Shepherd (BVSc, CCAB, MRCVS) Adapted for classroom use;2 Keeping ourselves safe near dogs 1 Do you have a pet dog? 2 Do you like dogs? 3 Does a relative of yours have a pet dog? 4 What makes dogs likely to bite? 5 How can we prevent a dog biting us? 6 Is a small

  1. Dogs catch human yawns

    Microsoft Academic Search

    Ramiro M. Joly-Mascheroni; Atsushi Senju; Alex J. Shepherd

    2008-01-01

    Summary This study is the first to demonstrate that human yawns are possibly contagious to domestic dogs (Canis familiaris). Twenty-nine dogs observed a human yawning or making control mouth movements. Twenty-one dogs yawned when they observed a human yawning, but control mouth movements did not elicit yawning from any of them. The presence of contagious yawning in dogs suggests that

  2. Cat and Dog Bites

    MedlinePLUS

    MENU Return to Web version Cat and Dog Bites Cat and Dog Bites How should I take care of a bite from a cat or a dog? Whether from a family pet or a neighborhood stray, cat and dog bites are common. Here are some ...

  3. rAAV2/7 vector-mediated overexpression of alpha-synuclein in mouse substantia nigra induces protein aggregation and progressive dose-dependent neurodegeneration

    PubMed Central

    2013-01-01

    Background Alpha-synuclein is a key protein implicated in the pathogenesis of Parkinson's disease (PD). It is the main component of the Lewy bodies, a cardinal neuropathological feature in the disease. In addition, whole locus multiplications and point mutations in the gene coding for alpha-synuclein lead to autosomal dominant monogenic PD. Over the past decade, research on PD has impelled the development of new animal models based on alpha-synuclein. In this context, transgenic mouse lines have failed to reproduce several hallmarks of PD, especially the strong and progressive dopaminergic neurodegeneration over time that occurs in the patients. In contrast, viral vector-based models in rats and non-human primates display prominent, although highly variable, nigral dopaminergic neuron loss. However, the few studies available on viral vector-mediated overexpression of alpha-synuclein in mice report a weak neurodegenerative process and no clear Lewy body-like pathology. To address this issue, we performed a comprehensive comparative study of alpha-synuclein overexpression by means of recombinant adeno-associated viral vectors serotype 2/7 (rAAV2/7) at different doses in adult mouse substantia nigra. Results We noted a significant and dose-dependent alpha-synucleinopathy over time upon nigral viral vector-mediated alpha-synuclein overexpression. We obtained a strong, progressive and dose-dependent loss of dopaminergic neurons in the substantia nigra, reaching a maximum of 82% after 8 weeks. This effect correlated with a reduction in tyrosine hydroxylase immunoreactivity in the striatum. Moreover, behavioural analysis revealed significant motor impairments from 12 weeks after injection on. In addition, we detected the presence of alpha-synuclein-positive aggregates in the remaining surviving neurons. When comparing wild-type to mutant A53T alpha-synuclein at the same vector dose, both induced a similar degree of cell death. These data were supported by a biochemical analysis that showed a net increase in soluble and insoluble alpha-synuclein expression over time to the same extent for both alpha-synuclein variants. Conclusions In conclusion, our in vivo data provide evidence that strong and significant alpha-synuclein-induced neuropathology and progressive dopaminergic neurodegeneration can be achieved in mouse brain by means of rAAV2/7. PMID:24267638

  4. Magnetic resonance imaging of the presumed normal canine adrenal glands.

    PubMed

    Llabres-Diaz, Francisco J; Dennis, Ruth

    2003-01-01

    Forty-three dogs without evidence of endocrine disease that underwent spinal or abdominal magnetic resonance imaging (MRI) for clinical reasons were studied. Because the procedures were not optimized for inclusion of the adrenal glands, they were not always visible in all planes. Eighty-five of the 86 adrenal glands were seen and only the left gland in a 6-month-old Irish wolfhound could not be found. The right adrenal gland lay cranial to the left in all of the animals in which both glands were seen. The best landmarks for localization of the glands were vascular; both adrenal glands were always cranial to the ipsilateral renal vessels and in the region of the celiac and cranial mesenteric arteries. Various measurements were made on all the available scan planes. In some dogs the whole adrenal gland was difficult to visualize clearly, and this hindered the measuring process, especially when the right adrenal gland was in close contact with the caudal vena cava. The adrenal glands were mainly linear in shape but also had a variable degree of modification of their poles, especially the cranial pole of the right adrenal gland, which tended to be consistently wider and to present different shapes (rounded, arrowhead, inverted P, hook-shaped, triangular, or dome-shaped). Two main patterns of signal intensity were seen on fast spin echo (FSE) sequences (T2-weighted, T1-weighted, and T1-weighted after administration of a paramagnetic contrast medium): homogeneous and hypointense to surroundings or a corticomedullary type pattern with a hyperintense central area surrounded by a hypointense rim of tissue. The outline of the left adrenal gland was always very clear. The clarity of outline of the right adrenal gland was more variable, especially if it was in contact with the liver or the caudal vena cava. It was felt that the amount of retroperitoneal fat was not as important as stated in the human literature for visualization of the adrenal glands and that with an appropriate selection of scan planes and pulse sequences good assessment of the adrenal glands can be performed with MRI in canine patients. PMID:12620044

  5. Adenovirus vector-mediated herpes simplex virus-thymidine kinase gene/ganciclovir system exhibits anti-tumor effects in an orthotopic hepatocellular carcinoma model.

    PubMed

    Zhu, Ruidong; Chen, Dexi; Lin, Dongdong; Lu, Fudong; Yin, Jiming; Li, Ning

    2014-07-01

    Adenovirus vector-mediated herpes simplex virus-thymidine kinase/ganciclovir (ADV.tk/GCV) system is a promising approach for cancer gene therapy. This study aimed to investigate the anti-tumor efficacy and the underlying mechanisms of ADV.tk/GCV system in orthotopic hepatocellular carcinoma (HCC) model. A total of 132 female nude mice orthotopic HCC models were established and tumors were directly injected with ADV.tk (5.0 x 10(6) vector particles/kg) or saline solution, 24 h later the animals were intraperitoneally administrated by ganciclovir (30 mg/kg) or saline solution for 7 consecutive days. We observed that ADV.tk/GCV resulted in a significant regression of tumor growth and a significant prolongation of survival of the mice. At each given time point, the percentages of cleaved caspae-3, caspase-9 and TUNEL positive cells were significantly higher in the ADV.tk + GCV group than saline group (P < 0.005), while CD31 and VEGF staining were significantly less in ADV.tk + GCV group than in saline group (P < 0.005). In summary, ADV.tk/GCV system exhibits dramatic anti-tumor effects in orthotopic hepatocellular carcinoma model by promoting apoptosis and inhibiting angiogenesis, and is a promising treatment strategy for hepatic carcinoma. PMID:25073402

  6. Inhibition of angiogenesis and HGF-cMET-elicited malignant processes in human hepatocellular carcinoma cells using adenoviral vector-mediated NK4 gene therapy.

    PubMed

    Heideman, Daniëlle A M; Overmeer, Renée M; van Beusechem, Victor W; Lamers, Wouter H; Hakvoort, Theodorus B M; Snijders, Peter J F; Craanen, Mikael E; Offerhaus, G Johan A; Meijer, Chris J L M; Gerritsen, Winald R

    2005-12-01

    NK4 is an hepatocyte growth factor (HGF)-antagonist and a broad angiogenesis inhibitor. NK4 gene therapy has confirmed antitumor efficacy on cancers with intact HGF-cMET signaling pathway. However, the feasibility to treat tumors in which the effect of the HGF-cMET signaling pathway is less unambiguous or may even be inhibitory on carcinogenesis, such as hepatocellular carcinoma (HCC) with NK4 needs further assessment. Therefore, we evaluated the effects of adenoviral vector-mediated expression of NK4 on the biological behavior of a series of HCC cell lines in vitro and on HepG2 xenografts in vivo. In vitro, transduction of HCC cell lines with the replication-deficient recombinant adenoviral vector AdCMV.NK4 resulted in significant inhibition of proliferation over and above the antimitogenic effects of HGF. In addition, HGF-induced scattering and invasion through matrigel were inhibited effectively. Moreover, transduced HCC cells produced sufficient amounts of NK4 protein to achieve bystander effects involving reduced migration of nontransduced tumor cells and reduced proliferation of endothelial cells. Finally, treatment of established HepG2 xenografts with AdCMV.NK4 resulted in significant tumor growth delay and significant reduction of intratumoral microvessel density. In conclusion, NK4 gene therapy is a promising strategy to treat HCC based on the pleiotropic functions of NK4 interfering with tumor growth, invasion, metastasis and angiogenesis. PMID:15905856

  7. Disease Precautions for Dog Walkers

    MedlinePLUS

    ... wind to unintended targets (such as other non-aggressive dogs or yourself), and use caution. The best ... dogs or dogs that you know have shown aggression toward people or other dogs. Make sure that ...

  8. Presumably bacterial remains in banded iron formations: beginning of investigations

    NASA Astrophysics Data System (ADS)

    Astafieva, M.

    2014-04-01

    Ancient Archaean and Protherozoic rocks are the model objects for investigation of rocks comprising astromaterials. Judging by their age these terrestrial rocks are the nearest to the rocks of meteorites. They are represented as a rule by deeply metamorphized layers of volcanogenic and volcanogenic-sedimentary rocks and bacterial-paleontological investigations of these rocks usually meet some difficulties. But paleontological studies of these rocks usually meet some difficulties. One of these difficulties is usual high metamorphization of rocks. That is why investigation of Archaean banded iron formations is of great importance. Banded iron formations are known everywhere. The oldest banded iron formations are met in Archaean. Their widest distribution was in Proterozoic. They are constituent part of metamorphic complexes of all ancient shields. Formation of these units ended in Phanerozoic. Peculiarity of their development in time, thin layering, rhythmyc repetitiveness are reasons of great interest to these formations. Banded iron formations are sedimentary rocks. Interbedding of ferrigenous (magnetite, hematite, siderite etc.) interlayers and siliceous layers are typical to these formations. Stratificatification is thin, thickness of interlayers is less than 1-2 mm. Iron content exceeds 15%. Potentially all minerals of ferrigenous interlayers could be of biogenic nature because both for oxygenized (hematite) and reduced (magnetite and siderite) minerals direct mechanism of bacterial production is established by microbiologists. Basic ore mineral of banded iron formations is magnetite. But magnetite origin is not clear till nowadays and this problem is very actual [2]. Nevertheless bacterial remains by themselves have not been found and it is not surprising. It is proved that finely dispersed non-completely formed magnetite compose basic mass of magnetite formed for example by thermophylic iron-reducing bacteria. Processes of structure arrangement and crystal enlargement are occurred under sediment ageing and abiogenic magnetite recrystallization [1]. That is why in nature in case of ancient sediments and metamorphic rocks it is almost impossible to reveal biogenic origin of magnetite [3]. We decided to begin studying problem of banded iron formations origin because of its great interest. Archaean (2.75 GA) banded iron formations of Olenegorsk deposit (Kola Peninsula) were chosen as a model object. Material was kindly lent us by our colleagues from Institute of Precambrian Geology and Geochronology - S. Felitsyn and N. Alfimova. Interesting results were received while bacterial-paleontological studying. Threadlike, coccoidal, dumbbell-like etc. forms presumably of bacterial nature were discovered. The most abundant and diverse forms are those close to coccoidal - the very cocci, oval, dumbbell-like etc. forms. Sizes of the most part of discovered objects about 1 ?m. Thread-like forms are met less often and mainly are represented by long thin single threads. The most part of biogenic structures was found in ferruginous interlayers. The whole rock fragments often consist almost completely from such structures, biogenic forms sink into rock matrix, some images show their location inside rock sample. There are no reasons to doubt that these biogenic forms were found in situ. In siliceous interlayers presumably biogenic forms are very rare. There are mainly long thin thread-like forms merged with the rock. As can be seen from the above it is possible to make preliminary conclusion about Archaean of banded iron formations biogenic origin and about microorganism participation in the process of banded iron formations formation. Investigations are continuing.

  9. Experimental assessment of presumed filtered density function models

    NASA Astrophysics Data System (ADS)

    Stetsyuk, V.; Soulopoulos, N.; Hardalupas, Y.; Taylor, A. M. K. P.

    2015-06-01

    Measured filtered density functions (FDFs) as well as assumed beta distribution model of mixture fraction and "subgrid" scale (SGS) scalar variance z '' 2 Ż , used typically in large eddy simulations, were studied by analysing experimental data, obtained from two-dimensional planar, laser induced fluorescence measurements in isothermal swirling turbulent flows at a constant Reynolds number of 29 000 for different swirl numbers (0.3, 0.58, and 1.07). Two-dimensional spatial filtering, by using a box filter, was performed in order to obtain the filtered variables, namely, resolved mean and "subgrid" scale scalar variance. These were used as inputs for assumed beta distribution of mixture fraction and top-hat FDF shape estimates. The presumed beta distribution model, top-hat FDF, and the measured filtered density functions were used to integrate a laminar flamelet solution in order to calculate the corresponding resolved temperature. The experimentally measured FDFs varied with the flow swirl number and both axial and radial positions in the flow. The FDFs were unimodal at flow regions with low SGS scalar variance, z '' 2 Ż < 0.01, and bimodal at regions with high SGS variance, z '' 2 Ż > 0.02. Bimodal FDF could be observed for a filter size of approximately 1.5-2 times the Batchelor scale. Unimodal FDF could be observed for a filter size as large as four times the Batchelor scale under well-mixed conditions. In addition, two common computational models (a gradient assumption and a scale similarity model) for the SGS scalar variance were used with the aim to evaluate their validity through comparison with the experimental data. It was found that the gradient assumption model performed generally better than the scale similarity one.

  10. Pre-Columbian origins of Native American dog breeds, with only limited replacement by European dogs, confirmed by mtDNA analysis

    PubMed Central

    van Asch, Barbara; Zhang, Ai-bing; Oskarsson, Mattias C. R.; Klütsch, Cornelya F. C.; Amorim, António; Savolainen, Peter

    2013-01-01

    Dogs were present in pre-Columbian America, presumably brought by early human migrants from Asia. Studies of free-ranging village/street dogs have indicated almost total replacement of these original dogs by European dogs, but the extent to which Arctic, North and South American breeds are descendants of the original population remains to be assessed. Using a comprehensive phylogeographic analysis, we traced the origin of the mitochondrial DNA lineages for Inuit, Eskimo and Greenland dogs, Alaskan Malamute, Chihuahua, xoloitzcuintli and perro sín pelo del Peru, by comparing to extensive samples of East Asian (n = 984) and European dogs (n = 639), and previously published pre-Columbian sequences. Evidence for a pre-Columbian origin was found for all these breeds, except Alaskan Malamute for which results were ambigous. No European influence was indicated for the Arctic breeds Inuit, Eskimo and Greenland dog, and North/South American breeds had at most 30% European female lineages, suggesting marginal replacement by European dogs. Genetic continuity through time was shown by the sharing of a unique haplotype between the Mexican breed Chihuahua and ancient Mexican samples. We also analysed free-ranging dogs, confirming limited pre-Columbian ancestry overall, but also identifying pockets of remaining populations with high proportion of indigenous ancestry, and we provide the first DNA-based evidence that the Carolina dog, a free-ranging population in the USA, may have an ancient Asian origin. PMID:23843389

  11. A comparison of dog–dog and dog–human play behaviour

    Microsoft Academic Search

    Nicola J. Rooney; John W. S. Bradshaw; Ian H. Robinson

    2000-01-01

    In the popular literature, it is often assumed that a single conceptual framework can be applied to both dog–dog and dog–human interactions, including play. We have, through three studies, tested the hypothesis that dog–dog and dog–human play are motivationally distinct. In an observational study of dogs being walked by their owners (N=402), dogs which were walked together, and had opportunities

  12. Helper-Dependent Adenoviral Vector-Mediated Delivery of Woodchuck-Specific Genes for Alpha Interferon (IFN ) and IFN : IFN  but Not IFN  Reduces Woodchuck Hepatitis Virus Replication in Chronic Infection In Vivo

    Microsoft Academic Search

    Melanie Fiedler; Florian Rodicker; Valentina Salucci; Mengji Lu; Luigi Aurisicchio; Uta Dahmen; Li Jun; Olaf Dirsch; Brigitte M. Putzer; Fabio Palombo; Michael Roggendorf

    2004-01-01

    Alpha interferon (IFN-) and IFN- are able to suppress hepadnavirus replication. The intrahepatic expression of high levels of IFN may enhance the antiviral activity. We investigated the effects of woodchuck- specific IFN- (wIFN-) and IFN-(wIFN-) on woodchuck hepatitis virus (WHV) replication in vivo by helper-dependent adenoviral (HD-Ad) vector-mediated gene transfer. The expression of biologically active IFNs was demonstrated in vitro

  13. Optimization of adenoviral vector–mediated transgene expression in the canine brain in vivo, and in canine glioma cells in vitro

    PubMed Central

    Candolfi, Marianela; Pluhar, G. Elizabeth; Kroeger, Kurt; Puntel, Mariana; Curtin, James; Barcia, Carlos; Muhammad, A.K.M. Ghulam; Xiong, Weidong; Liu, Chunyan; Mondkar, Sonali; Kuoy, William; Kang, Terry; McNeil, Elizabeth A.; Freese, Andrew B.; Ohlfest, John R.; Moore, Peter; Palmer, Donna; Ng, Phillip; Young, John D.; Lowenstein, Pedro R.; Castro, Maria G.

    2007-01-01

    Expression of the immune-stimulatory molecule Fms-like tyrosine kinase 3 ligand (Flt3L) and the conditional cytotoxic enzyme herpes simplex virus type 1 thymidine kinase (HSV1-TK) provides long-term immune-mediated survival of large glioblastoma multiforme (GBM) models in rodents. A limitation for predictive testing of novel antiglioma therapies has been the lack of a glioma model in a large animal. Dogs bearing spontaneous GBM may constitute an attractive large-animal model for GBM, which so far has remained underappreciated. In preparation for a clinical trial in dogs bearing spontaneous GBMs, we tested and optimized adenovirus-mediated transgene expression with negligible toxicity in the dog brain in vivo and in canine J3T glioma cells. Expression of the marker gene ?-galactosidase (?-Gal) was higher when driven by the murine (m) than the human (h) cytomegalovirus (CMV) promoter in the dog brain in vivo, without enhanced inflammation. In the canine brain, ?-Gal was expressed mostly in astrocytes. ?-Gal activity in J3T cells was also higher with the mCMV than the hCMV promoter driving tetracycline-dependent (TetON) trans-gene expression within high-capacity adenovirus vectors (HC-Ads). Dog glioma cells were efficiently transduced by HC-Ads expressing mCMV-driven HSV1-TK, which induced 90% reduction in cell viability in the presence of ganciclovir. J3T cells were also effectively transduced with HC-Ads expressing Flt3L under the control of the regulatable TetON promoter system, and as predicted, Flt3L release was stringently inducer dependent. HC-Ads encoding therapeutic transgenes under the control of regulatory sequences driven by the mCMV promoter are excellent vectors for the treatment of spontaneous GBM in dogs, which constitute an ideal preclinical animal model. PMID:17522335

  14. Lentiviral Vector-Mediated Gradients of GDNF in the Injured Peripheral Nerve: Effects on Nerve Coil Formation, Schwann Cell Maturation and Myelination

    PubMed Central

    Eggers, Ruben; de Winter, Fred; Hoyng, Stefan A.; Roet, Kasper C. D.; Ehlert, Erich M.; Malessy, Martijn J. A.; Verhaagen, Joost; Tannemaat, Martijn R.

    2013-01-01

    Although the peripheral nerve is capable of regeneration, only a small minority of patients regain normal function after surgical reconstruction of a major peripheral nerve lesion, resulting in a severe and lasting negative impact on the quality of life. Glial cell-line derived neurotrophic factor (GDNF) has potent survival- and outgrowth-promoting effects on motoneurons, but locally elevated levels of GDNF cause trapping of regenerating axons and the formation of nerve coils. This phenomenon has been called the “candy store” effect. In this study we created gradients of GDNF in the sciatic nerve after a ventral root avulsion. This approach also allowed us to study the effect of increasing concentrations of GDNF on Schwann cell proliferation and morphology in the injured peripheral nerve. We demonstrate that lentiviral vectors can be used to create a 4 cm long GDNF gradient in the intact and lesioned rat sciatic nerve. Nerve coils were formed throughout the gradient and the number and size of the nerve coils increased with increasing GDNF levels in the nerve. In the nerve coils, Schwann cell density is increased, their morphology is disrupted and myelination of axons is severely impaired. The total number of regenerated and surviving motoneurons is not enhanced after the distal application of a GDNF gradient, but increased sprouting does result in higher number of motor axon in the distal segment of the sciatic nerve. These results show that lentiviral vector mediated overexpression of GDNF exerts multiple effects on both Schwann cells and axons and that nerve coil formation already occurs at relatively low concentrations of exogenous GDNF. Controlled expression of GDNF, by using a viral vector with regulatable GDNF expression, may be required to avoid motor axon trapping and to prevent the effects on Schwann cell proliferation and myelination. PMID:23951085

  15. Genetic modification of mouse bone marrow by lentiviral vector-mediated delivery of HPRT shRNA confers chemoprotection against 6-thioguanine cytotoxicity

    PubMed Central

    Hacke, Katrin; Treger, Janet A.; Bogan, Brooke T.; Schiestl, Robert H.; Kasahara, Noriyuki

    2014-01-01

    We have recently developed a novel and highly efficient strategy that exclusively employs the purine analog 6-thioguanine (6TG) for both pre-transplant conditioning and post-transplant chemoselection of hypoxanthine-guanine phosphoribosyltransferase (HPRT)-deficient bone marrow (BM). In a mouse BM transplant model, combined 6TG preconditioning and in vivo chemoselection consistently achieved >95% engraftment of HPRT-deficient donor BM and long-term reconstitution of histologically and immunophenotypically normal hematopoiesis in both primary and secondary recipients, without significant toxicity and in the absence of any other cytotoxic conditioning regimen. In order to translate this strategy for combined 6TG conditioning and chemoselection into a clinically feasible approach, it is necessary to develop methods for genetic modification of normal HSC to render them HPRT-deficient and thus 6TG-resistant. Here we investigated a strategy to reduce HPRT expression and thereby confer protection against 6TG myelotoxicity to primary murine bone marrow cells by RNA interference (RNAi). Accordingly, we constructed and validated a lentiviral gene transfer vector expressing short-hairpin RNA (shRNA) that targets the murine HPRT gene. Our results showed that lentiviral vector-mediated delivery of HPRT-targeted shRNA could achieve effective and long-term reduction of HPRT expression. Furthermore, in both an established murine cell line as well as in primary murine bone marrow cells, lentiviral transduction with HPRT-targeted shRNA was associated with enhanced resistance to 6TG cytotoxicity in vitro. Hence this represents a translationally feasible method to genetically engineer HSC for implementation of 6TG-mediated preconditioning and in vivo chemoselection. PMID:23769104

  16. Lentiviral vector-mediated survivin shRNA delivery in gastric cancer cell lines significantly inhibits cell proliferation and tumor growth.

    PubMed

    Habib, Raees; Akhtar, Javed; Taqi, Mohammad; Yu, Che; Zhang, Chunqing

    2015-08-01

    It has been well documented that survivin has multiple functions including cytoprotection, inhibition of cell death, and cell cycle regulation, particularly at the mitotic stage of the cell cycle, all of which favor cancer survival. Its expression in normal tissue is developmentally regulated, and any type of deregulation in survivin expression favors cancer survival. Gastric cancer is one of the most common malignancies and the second most common cause of cancer-related mortality worldwide. The molecular mechanisms involved in the transformation and progression of gastric cancer remain unclear. In the present study, we investigated the effect of lentiviral vector-mediated survivin shRNA delivery in gastric cancer cell lines. Lentiviral-mediated survivin shRNA was used to knock down survivin expression in gastric cancer cell lines SGC-7901, MGC-803 and MKN-28. The ?ranswell chemotaxis and the CCK-8 assays were used to assess the migration and proliferation of the tumor cells, respectively. TUNEL assay was used to detect apoptosis. Quantitative real-time PCR and western blot analysis were used to quantify mRNA and protein levels, respectively. Our results demonstrated that lentiviral-mediated RNAi markedly suppressed the survivin expression in all three gastric cancer cell lines. Significant decrease in survivin mRNA and protein expression were detected in the gastric cancer cell lines stably transfected with the lentiviral survivin shRNA vector, and knockdown of survivin also significantly inhibited the proliferation and migration in the gastric cancer cells and tumorigenicity in a xenograft animal model. Our results indicated that aberrant high cytoplasmic survivin expression in gastric cancer cells is associated with increased proliferation index and tumor growth. In conclusion, our results suggest that lentiviral-mediated gene therapy has the potential to be developed into a novel therapeutic strategy for the treatment of gastric cancer. PMID:26043753

  17. Seroprevalence of Ehrlichia canis and of Canine Granulocytic Ehrlichia Infection in Dogs in Switzerland

    PubMed Central

    Pusterla, Nicola; Pusterla, Jeannine Berger; Deplazes, Peter; Wolfensberger, Celestine; Müller, Werner; Hörauf, Angelika; Reusch, Claudia; Lutz, Hans

    1998-01-01

    Serum samples from 996 dogs in Switzerland were examined for antibodies to Ehrlichia canis and to the agent causing canine granulocytic ehrlichiosis (CGE). Ehrlichiosis, borreliosis, and systemic illness not associated with ticks were suspected in 75, 122, and 157 of these dogs, respectively. The remainder of the serum samples were obtained from clinically healthy dogs which resided north (n = 235) or south (n = 407) of the Alps. The serum samples were tested by an indirect immunofluorescence technique for antibodies to the two agents incriminated, E. canis and Ehrlichia phagocytophila, a surrogate marker of the agent of CGE. Twenty-two of 996 (2.2%) serum samples had antibodies to E. canis and were distributed as follows: 20 of 75 (26.7%) samples from dogs suspected of having ehrlichiosis, 1 of 122 (0.8%) from dogs suspected of having borreliosis, and 1 of 407 (0.2%) from healthy dogs which resided south of the Alps. Of the 75 (7.5%) serum samples that had antibodies to E. phagocytophila, significantly more samples were from ill dogs than from healthy dogs. Among the sera from healthy dogs, antibodies to E. phagocytophila were significantly more prevalent in the north. Because seropositive dogs had a history of travel outside Switzerland and because Rhipicephalus sanguineus is found exclusively south of the Alps, it was presumed that, in contrast to the agent of CGE, E. canis is not indigenous to Switzerland. PMID:9817854

  18. Is That Dog a Pit Bull? A Cross-Country Comparison of Perceptions of Shelter Workers Regarding Breed Identification

    PubMed Central

    Hoffman, Christy L.; Harrison, Natalie; Wolff, London; Westgarth, Carri

    2014-01-01

    Bull breeds are commonly kept as companion animals, but the pit bull terrier is restricted by breed-specific legislation (BSL) in parts of the United States and throughout the United Kingdom. Shelter workers must decide which breed(s) a dog is. This decision may influence the dog's fate, particularly in places with BSL. In this study, shelter workers in the United States and United Kingdom were shown pictures of 20 dogs and were asked what breed each dog was, how they determined each dog's breed, whether each dog was a pit bull, and what they expected the fate of each dog to be. There was much variation in responses both between and within the United States and United Kingdom. UK participants frequently labeled dogs commonly considered by U.S. participants to be pit bulls as Staffordshire bull terriers. UK participants were more likely to say their shelters would euthanize dogs deemed to be pit bulls. Most participants noted using dogs' physical features to determine breed, and 41% affected by BSL indicated they would knowingly mislabel a dog of a restricted breed, presumably to increase the dog's adoption chances. PMID:24673506

  19. Is that dog a pit bull? A cross-country comparison of perceptions of shelter workers regarding breed identification.

    PubMed

    Hoffman, Christy L; Harrison, Natalie; Wolff, London; Westgarth, Carri

    2014-01-01

    Bull breeds are commonly kept as companion animals, but the pit bull terrier is restricted by breed-specific legislation (BSL) in parts of the United States and throughout the United Kingdom. Shelter workers must decide which breed(s) a dog is. This decision may influence the dog's fate, particularly in places with BSL. In this study, shelter workers in the United States and United Kingdom were shown pictures of 20 dogs and were asked what breed each dog was, how they determined each dog's breed, whether each dog was a pit bull, and what they expected the fate of each dog to be. There was much variation in responses both between and within the United States and United Kingdom. UK participants frequently labeled dogs commonly considered by U.S. participants to be pit bulls as Staffordshire bull terriers. UK participants were more likely to say their shelters would euthanize dogs deemed to be pit bulls. Most participants noted using dogs' physical features to determine breed, and 41% affected by BSL indicated they would knowingly mislabel a dog of a restricted breed, presumably to increase the dog's adoption chances. PMID:24673506

  20. Dogs catch human yawns.

    PubMed

    Joly-Mascheroni, Ramiro M; Senju, Atsushi; Shepherd, Alex J

    2008-10-23

    This study is the first to demonstrate that human yawns are possibly contagious to domestic dogs (Canis familiaris). Twenty-nine dogs observed a human yawning or making control mouth movements. Twenty-one dogs yawned when they observed a human yawning, but control mouth movements did not elicit yawning from any of them. The presence of contagious yawning in dogs suggests that this phenomenon is not specific to primate species and may indicate that dogs possess the capacity for a rudimentary form of empathy. Since yawning is known to modulate the levels of arousal, yawn contagion may help coordinate dog-human interaction and communication. Understanding the mechanism as well as the function of contagious yawning between humans and dogs requires more detailed investigation. PMID:18682357

  1. The Influence of Presumed Media Influence on Women’s Desire to Be Thin

    Microsoft Academic Search

    Sung-Yeon Park

    2005-01-01

    This study investigated the effect of magazine use on the desire to be thin within the theoretical framework of presumed influence. Structural equation modeling supported the hypothesis that reading beauty and fashion magazines increased the drive for thinness both directly and indirectly. The indirect pathway included the perceived prevalence of the thin ideal in mass media, the presumed influence of

  2. The Impact of Presumed Consent Legislation on Cadaveric Organ Donation: A Cross Country Study

    Microsoft Academic Search

    Alberto Abadie; Sebastien Gay

    2004-01-01

    In the U.S., Great Britain, and in many other countries, the gap between the demand and the supply of human organs for transplantation is on the rise, despite the efforts of governments and health agencies to promote donor registration. In some countries of continental Europe, however, cadaveric organ procurement is based on the principle of presumed consent. Under presumed consent

  3. The impact of presumed consent legislation on cadaveric organ donation: A cross-country study

    Microsoft Academic Search

    Alberto Abadie; Sebastien Gay

    2006-01-01

    In the U.S., Great Britain and in many other countries, the gap between the demand and the supply of human organs for transplantation is on the rise, despite the efforts of governments and health agencies to promote donor registration. In some countries of continental Europe, however, cadaveric organ procurement is based on the principle of presumed consent. Under presumed consent

  4. Dogs that bite

    Microsoft Academic Search

    P C Shewell; J D Nancarrow

    1991-01-01

    OBJECTIVE--To study the circumstances of dog bites and identify risk factors. DESIGN--Postal questionnaire survey and case note review of victims of dog bites referred between 1982 and 1989. SETTING--One referral based regional plastic surgery unit. PATIENTS--146 consecutive patients referred for primary treatment of dog bites, for whom current addresses were available for 133, 107 (81%) of whom returned the questionnaire.

  5. Dogs that bite.

    PubMed Central

    Shewell, P C; Nancarrow, J D

    1991-01-01

    OBJECTIVE--To study the circumstances of dog bites and identify risk factors. DESIGN--Postal questionnaire survey and case note review of victims of dog bites referred between 1982 and 1989. SETTING--One referral based regional plastic surgery unit. PATIENTS--146 consecutive patients referred for primary treatment of dog bites, for whom current addresses were available for 133, 107 (81%) of whom returned the questionnaire. RESULTS--The male to female ratio was 74:72; 79 (54%) patients were aged below 15 years. The commonest dogs producing bites were Staffordshire bull terriers (15 cases), Jack Russell terriers (13), medium sized mongrels (10), and Alsatians (nine). 82 of 96 (85%) dogs were male. 29 of 47 (62%) adults were bitten at home and 45 of 60 (75%) children at a friend's, neighbour's, or relative's house. 91 of 107 (85%) bites occurred in the dog's home. Bites occurred during playing with 13 (12%), petting 14 (13%), or waking 16 (15%) dogs. 45 (42%) bites were judged as unprovoked. 32 bites were identified as severe and 11 attacks as sustained. CONCLUSIONS--Most victims are bitten by male dogs which they either own or have had frequent contact with, and the bite occurs in the dog's home. PMID:1782490

  6. Birds and Beaches, Dogs and Leashes: Dog Owners' Sense of Obligation to Leash Dogs on Beaches in Victoria, Australia

    Microsoft Academic Search

    Kathryn J. H. Williams; Michael A. Weston; Stacey Henry; Grainne S. Maguire

    2009-01-01

    Domesticated dogs threaten the conservation of beach-nesting birds in Australia through disturbance, and destruction of eggs and chicks. Leashing of dogs can improve conservation outcomes, but few dogs are leashed on beaches. We surveyed dog owners to explore their sense of obligation to leash dogs on beaches. Dog owners were more likely to feel obliged to leash their dog when

  7. Chloramphenicol toxicity in dogs.

    PubMed

    Watson, A D

    1977-07-01

    Twenty dogs were given chloramphenicol by mouth night and morning for 14 days: six dogs were dosed at 225 mg/kg/day, four each at 175 and 125 mg/kg/day and three each at 275 and 75 mg/kg/day. Six control dogs were given empty gelatin capsules twice daily for the same period. Dogs dosed at 75 mg/kg consumed more food and gained a little more weight than the control dogs, while those in the 175, 225 and 275 mg/kg groups ate less and lost weight. Four dogs dosed at 175 mg/kg or above became dull and depressed and virtually ceased to eat. No changes were observed in erythrocyte and reticulocyte counts, haemoglobin concentration, packed cell volume or total and differential leukocyte counts during the experiment. Bone marrow examination showed suppression of erythropoiesis in four of nine dogs dosed at 225 or 275 mg/kg/day. In addition, there was evidence of decreased mitotic activity and reduced rate of granulocytopoiesis in the 275 mg/kg group. Vacuolation of marrow cells was not observed. The two toxic effects observed (depression and hypophagia on the one hand, marrow suppression on the other) occurred separately or together in individual dogs. PMID:905657

  8. Drawing Prairie Dog Blood

    USGS Multimedia Gallery

    Blood is taken from an anaesthetized prairie dog in Wind Cave National Park.  Over 30 organizations and agencies are testing a USGS-developed oral vaccine to prevent the spread of plague in prairie dogs. If successful, the sylvatic plague vaccine could help protect endanger...

  9. Prairie Dog Under Anesthesia

    USGS Multimedia Gallery

    Over 30 organizations and agencies are testing a USGS-developed oral vaccine to prevent the spread of plague in prairie dogs. If successful, the sylvatic plague vaccine could help protect endangered black-footed ferrets in the western U.S. because the ferrets rely on prairie dogs for ...

  10. Sampling Prairie Dog Fur

    USGS Multimedia Gallery

    Fur samples are taken from an anaesthetized prairie dog in Wind Cave National Park.  Over 30 organizations and agencies are testing a USGS-developed oral vaccine to prevent the spread of plague in prairie dogs. If successful, the sylvatic plague vaccine could help protect e...

  11. Anesthetizing a Prairie Dog

    USGS Multimedia Gallery

    National Park Service veterinarian Kevin Castle places a prairie dog under anesthesia in Wind Cave National Park. He will tag this trapped prairie dog and take hair, whisker, and blood samples before scientists release the animal back into the wild. Over 30 organizations and agencies are&...

  12. Prairie Dog in Trap

    USGS Multimedia Gallery

    A prairie dog trapped outside its burrow in Wind Cave National Park waits for a crew of scientists to arrive. The animal is part of a field test to determine the effectiveness of a USGS-developed oral sylvatic plague vaccine (SPV). This prairie dog will either be brought to a research van for blood ...

  13. Marked Prairie Dog

    USGS Multimedia Gallery

    The chin of an anaesthetized prairie dog in Wind Cave National Park is marked before the animal is released back into the wild. Over 30 organizations and agencies are testing a USGS-developed oral vaccine to prevent the spread of plague in prairie dogs. If successful, the sylvat...

  14. Trapped Prairie Dog

    USGS Multimedia Gallery

    A prairie dog trapped outside its burrow in Wind Cave National Park waits for a crew of scientists to arrive. The animal is part of a field test to determine the effectiveness of a USGS-developed oral sylvatic plague vaccine (SPV). This prairie dog will either be brought to a research van for blood ...

  15. Prairie Dog Tagging

    USGS Multimedia Gallery

    An anaesthetized prairie dog is tagged in Wind Cave National Park.  Over 30 organizations and agencies are testing a USGS-developed oral vaccine to prevent the spread of plague in prairie dogs. If successful, the sylvatic plague vaccine could help protect endangered black-f...

  16. One Dog Policy

    E-print Network

    Hacker, Randi

    2009-08-19

    Broadcast Transcript: First the one child policy and now the one dog policy. First in Beijing and now in Guangzhou, the government is limiting the number of dogs in any household to one. And the regulation wasn't grandfathered in, meaning if you had...

  17. Dogs Over Babies

    E-print Network

    Hacker, Randi; Tsutsui, William

    2007-08-19

    wee babe you find a wee dog. In a frilly t-shirt. Meet Japan's newest demographic: Career-oriented women who choose dogs instead of babies, careers instead of motherhood. These women spend big bucks on doggie accessories, doggie parties and doggie spas...

  18. Carolyn with Prairie Dog

    USGS Multimedia Gallery

    The USGS National Wildlife Health Center works to identify, track, and prevent wildlife disease. A USGS technician works with a prairie dog as part of the center's efforts to protect prairie dogs, and in turn the endangered black-footed ferret, from plague....

  19. Presumed Guilty.

    ERIC Educational Resources Information Center

    Conkling, Winifred

    1991-01-01

    A Connecticut teacher who was fired after being accused of improperly touching a student tells the story of his ordeal. In the months following his termination, his mental health deteriorated as the media made frequent sensational reports. He feels, even if he wins his countersuit, he cannot be fully vindicated. (SM)

  20. Dogs Are Not for Dinner

    E-print Network

    Hacker, Randi

    2011-02-23

    Broadcast Transcript: Dogs. They're not just for dinner anymore. Over the years, many a Chinese diner has cooked and served dog and there's a story about an emperor from ancient times whose favorite meat was dog meat. And while dog is still...

  1. The Discourse of Dog Fighting

    Microsoft Academic Search

    Linda Kalof; Carl Taylor

    2007-01-01

    In this essay, we discuss dog fighting as a blood sport with a history embedded in the status-driven display of masculinity, power and violence. Based on published reports and interviews with those living and working in dog fighting neighborhoods, we show that the contemporary cultural knowledge of dog fighting is a discourse with multiple meanings: for those who pit dogs

  2. Animal Planet: Dog Breed Directory

    NSDL National Science Digital Library

    Are you considering bringing a canine into the family, and wondering which type of dog would be the best fit? This website from Animal Planet provides potential dog owners with information about a variety of breeds. The site directory lists dogs under such categories as Hound, Sporting, Terrier, Working, Herding, and more. Site visitors can view profiles for many different types of dogs including the Bernese Mountain Dog, Irish Setter, Old English Sheepdog, and Tibetan Spaniel. Dog profiles contain a photograph, Rating of Characteristics; and concise sections addressing History, Temperament, Form and Function, Upkeep, and Health. Profiles also include a hyperlinked list of related dogs.

  3. Dangerous dogs: culprits or victims?

    PubMed

    Mills, Georgina

    2014-12-01

    Dangerous dogs and dog bite incidents are rarely out of the news and are a matter of great public interest, but what can be done to tackle this issue and are the dogs really to blame? A debate at the BVA Congress at the London Vet Show discussed the complexities surrounding dog bites and dog behaviour, and looked at possible ways of preventing future incidents. Georgina Mills reports. PMID:25480896

  4. Dogs discriminate identical twins.

    PubMed

    Pinc, Ludvík; Bartoš, Lud?k; Reslová, Alice; Kotrba, Radim

    2011-01-01

    Earlier studies have shown variation among experimental attempts to establish whether human monozygotic twins that are genetically identical also have identical individual scents. In none of the cases were the dogs able to distinguish all the individual scents of monozygotic twins living in the same environment if the scents were presented to them separately. Ten specially trained police German Shepherd dogs of three Czech Republic Police Regional Headquarters were used for scent identification in our study. The dogs were supposed to match scents of two monozygotic pairs (5 and 7 years old) and two dizygotic twin pairs (8 and 13 years old). Scents were collected on cotton squares stored in glass jars. Dog handlers were blind to the experiment details. In each trial (line-up), one scent was used as a starting scent and the dog was then sent to determine if any of the 7 presented glass jars contained a matching scent. Scents of children of similar ages were used as distractors. In the matching procedure, the dogs matched correctly the scent of one twin with the other, as well as two scents collected from every single identical and non-identical twin to prove their efficacy and likewise, the presence of the matching twin scent in any given glass jar. All dogs in all trials distinguished correctly the scents of identical as well as non-identical twins. All dogs similarly matched positively two scents collected from the same individuals. Our findings indicated that specially trained German Shepherd dogs are able to distinguish individual scents of identical twins despite the fact that they live in the same environment, eat the same food and even if the scents are not presented to them simultaneously. PMID:21698282

  5. 48 CFR 50.205-4 - Authorization of awards made presuming SAFETY Act designation or certification after contract award.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ...Authorization of awards made presuming SAFETY Act designation or certification...ACQUISITION REGULATION CONTRACT MANAGEMENT EXTRAORDINARY CONTRACTUAL ACTIONS AND THE SAFETY ACT Support Anti-terrorism...of awards made presuming SAFETY Act designation or...

  6. Jealousy in Dogs

    PubMed Central

    Harris, Christine R.; Prouvost, Caroline

    2014-01-01

    It is commonly assumed that jealousy is unique to humans, partially because of the complex cognitions often involved in this emotion. However, from a functional perspective, one might expect that an emotion that evolved to protect social bonds from interlopers might exist in other social species, particularly one as cognitively sophisticated as the dog. The current experiment adapted a paradigm from human infant studies to examine jealousy in domestic dogs. We found that dogs exhibited significantly more jealous behaviors (e.g., snapping, getting between the owner and object, pushing/touching the object/owner) when their owners displayed affectionate behaviors towards what appeared to be another dog as compared to nonsocial objects. These results lend support to the hypothesis that jealousy has some “primordial” form that exists in human infants and in at least one other social species besides humans. PMID:25054800

  7. Nutrition of aging dogs.

    PubMed

    Larsen, Jennifer A; Farcas, Amy

    2014-07-01

    Aging is a normal process characterized by a variety of physiologic changes. Geriatric dogs are also more likely to be afflicted with certain disease conditions. Both normal and abnormal physiologic changes associated with aging in the dog may be amenable to nutritional intervention. Specific alterations in nutrients or in dietary characteristics can be beneficial; however, these are best done in the context of an individualized nutritional assessment and monitoring paradigm. PMID:24951344

  8. Let the Dogs Out!

    NSDL National Science Digital Library

    Andrea S. Foster

    2003-04-01

    Even the simplest of toys can be great tools for promoting interest in physical science principles. The author developed a strategy based on the 5E learning cycle (Engage, Explore, Explanation, Elaboration, and Evaluation) that uses bobble head dogs to explore the principles of force and motion, systems, and simple machines. The activity is designed to have students make predictions and ask questions about the internal mechanism that allows the dog's head to bobble, and then construct their own model using simple materials.

  9. Prairie dog care and husbandry.

    PubMed

    Pilny, Anthony A; Hess, Laurie

    2004-05-01

    The species of prairie dog most commonly found in the pet trade is the black-tailed prairie dog, Cynomus ludovicianus. These prairie dogs are active, playful, and strong rodents that can make wonderful, affectionate pets when they are properly socialized and given attention. However, with a life span of 8 to 12 years, prairie dogs require a lot of care and a long-term commitment. Prairie dogs live in colonies; thus, they are highly social animals. Potential owners should understand a prairie dog's need for attention before adopting one. PMID:15145390

  10. Helper-Dependent Adenoviral Vector-Mediated Delivery of Woodchuck-Specific Genes for Alpha Interferon (IFN-?) and IFN-?: IFN-? but Not IFN-? Reduces Woodchuck Hepatitis Virus Replication in Chronic Infection In Vivo

    PubMed Central

    Fiedler, Melanie; Rödicker, Florian; Salucci, Valentina; Lu, Mengji; Aurisicchio, Luigi; Dahmen, Uta; Jun, Li; Dirsch, Olaf; Pützer, Brigitte M.; Palombo, Fabio; Roggendorf, Michael

    2004-01-01

    Alpha interferon (IFN-?) and IFN-? are able to suppress hepadnavirus replication. The intrahepatic expression of high levels of IFN may enhance the antiviral activity. We investigated the effects of woodchuck-specific IFN-? (wIFN-?) and IFN-?(wIFN-?) on woodchuck hepatitis virus (WHV) replication in vivo by helper-dependent adenoviral (HD-Ad) vector-mediated gene transfer. The expression of biologically active IFNs was demonstrated in vitro after transduction of woodchuck cells with HD-Ad vectors encoding wIFN-? (HD-AdwIFN-?) or wIFN-? (HD-AdwIFN-?). The transduction efficacy of the HD-Ad vector in woodchuck liver in vivo was tested with a vector expressing green fluorescence protein (GFP). Immunohistochemical staining of liver samples on day 5 after injection showed expression of GFP in a high percentage of liver cells surrounding the central vein. The transduction of livers of WHV carriers in vivo with HD-AdwIFN-? or HD-AdwIFN-? induced levels of biologically active IFN, which could be measured in the sera of these animals. Expression of wIFN-? in the liver reduced intrahepatic WHV replication and WHV DNA in sera of about 1 log step in two of two woodchucks. Transduction with HD-AdwIFN-?, however, reduced WHV replicative intermediates only slightly in two of three animals, which was not accompanied with significant changes in the WHV DNA in sera. We demonstrated for the first time the successful HD-Ad vector-mediated transfer of genes for IFN-? and IFN-? in vivo and timely limited reduction of WHV replication by wIFN-?, but not by wIFN-?. PMID:15331744

  11. Effects of doxycycline on heartworm embryogenesis, transmission, circulating microfilaria, and adult worms in microfilaremic dogs.

    PubMed

    McCall, J W; Kramer, L; Genchi, C; Guerrero, J; Dzimianski, M T; Mansour, A; McCall, S D; Carson, B

    2014-11-15

    Tetracycline treatment of animals or humans infected with filariae that harbor Wolbachia endosymbionts blocks further embryogenesis, and existing microfilariae gradually die. This treatment also kills developing larvae and has a slow-kill effect on adult filariae, all presumably due to elimination of the Wolbachia. Also, Dirofilaria immitis microfilariae in blood collected from dogs up to 25 days after the last dose of doxycycline developed to infective L3 that were normal in appearance and motility in mosquitoes but did not continue to develop or migrate normally after subcutaneous (SC) injection into dogs. The present study was designed to determine whether heartworm microfilariae collected at later times after treatment would regain the ability to continue normal development in a dog. The study also was expected to yield valuable data on the effects of treatment on microfilariae and antigen levels and adult worms. The study was conducted in 16 dogs as two separate replicates at different times. A total of five dogs (two in Replicate A and three in Replicate B) infected either by SC injection of L3 or intravenous transplantation of adult heartworms were given doxycycline orally at 10mg/kg twice daily for 30 days, with three untreated controls. Microfilarial counts in the five treated dogs gradually declined during the 12-13 months after treatment initiation. Two dogs were amicrofilaremic before necropsy and three had 13 or fewer microfilariae/ml. Only one treated dog was negative for heartworm antigen before necropsy. Overall, treated dogs generally had fewer live adult heartworms than controls, and most of their live worms were moribund. All three control dogs remained positive for microfilariae and antigen and had many live worms. L3 from mosquitoes fed on blood collected 73-77 or 161-164 days after initiation of doxycycline treatments were injected SC into five dogs. None of the dogs injected with L3 from mosquitoes fed on blood from doxycycline-treated dogs were ever positive for microfilariae or antigen, and none had worms at necropsy; three control dogs were positive for microfilariae and antigen and had many live worms. These data indicate that doxycycline treatment of microfilaremic dogs gradually reduces numbers of microfilariae and blocks further transmission of heartworms. This latter effect should be highly effective in reducing the rate of selection of heartworms with genes that confer resistance to macrocyclic lactone preventives and microfilaricides. The data also suggest that doxycycline has a slow-kill effect on adult heartworms. PMID:25458121

  12. Cryptosporidium spp. in Domestic Dogs: the “Dog” Genotype

    PubMed Central

    Morgan, Una M.; Xiao, Lihua; Monis, Paul; Fall, Abbie; Irwin, Peter J.; Fayer, Ronald; Denholm, Karen M.; Limor, Josef; Lal, Altaf; Thompson, R. C. Andrew

    2000-01-01

    Genetic and phylogenetic characterization of Cryptosporidium isolates at two loci (18S rRNA gene and heat shock gene) from both Australian and United States dogs demonstrated that dog-derived Cryptosporidium isolates had a distinct genotype which is conserved across geographic areas. Phylogenetic analysis provided support for the idea that the “dog” genotype is, in fact, a valid species. PMID:10788404

  13. Metastatic carcinoma of presumed prostatic origin in cremated bones from the first century A.D.

    PubMed

    Grévin, G; Lagier, R; Baud, C A

    1997-09-01

    A cremated pelvis dating from the first century A.D. showed evidence of osteosclerotic metastasis, presumably secondary to prostate carcinoma. The case demonstrates the importance of microradiography in palaeopathology as well as some of the structural changes seen in cremated bone. PMID:9334843

  14. Dysversion of the optic disc and axial length measurements in a presumed amblyopic population

    Microsoft Academic Search

    Philip Lempert; Lynn Porter

    1998-01-01

    Purpose: Our purpose was to evaluate anatomic variations of eyes presumed to be amblyopic. Method: Computer imaging and photography of the optic discs of 205 amblyopic subjects were performed and the axial lengths of 183 of the subjects were measured. The paired optic nerve images were evaluated for symmetry of disc contours and orientation of central blood vessels to detect

  15. Antimicrobial management of presumed microbial keratitis: guidelines for treatment of central and peripheral ulcers

    Microsoft Academic Search

    H G B Bennett; J Hay; C M Kirkness; D V Seal; Penny Devonshire

    1998-01-01

    AIMSTo determine the quantitative relation between the major risk factors for microbial keratitis of previous ocular surface disease and contact lens wear and central and peripheral infiltration, often associated with ulceration, in order to establish a rational chemotherapeutic management algorithm.METHODSData from 55 patients were collected over a 10 month period. All cases of presumed microbial keratitis where corneal scrapes had

  16. 718 Book Reviews public' (p. vii) and one presumably to a more scholarly audience. This history

    E-print Network

    Fitelson, Branden

    718 Book Reviews public' (p. vii) and one presumably to a more scholarly audience. This history). Of course, every book must treat some things more painstakingly than others. But scholars, at any rate to obscure the book's undeni- able merits. It is an important work, which should interest and stimulate

  17. Molecular diagnosis of diphyllobothriasis in Spain, most presumably acquired via imported fish, or sojourn abroad

    PubMed Central

    Pastor-Valle, J; González, L M; Martín-Clemente, J P; Merino, F J; Gottstein, B; Gárate, T

    2014-01-01

    Human diphyllobothriasis is sporadically detected in Spain. Diphyllobothrium latum and Diplogonoporus balaenopterae have been identified. In the study, four cases of presumably imported diphyllobothriasis in Spanish patients were appraised. Molecular diagnosis allowed us to identify ‘exotic’ fish tapeworms such as Diplogonoporus balaenopterae in one patient and Diphyllobothrium pacificum in the others. PMID:25356331

  18. Presumed Perinatal Stroke in a Child with Down Syndrome and Moyamoya Disease

    ERIC Educational Resources Information Center

    Pysden, Karen; Fallon, Penny; Moorthy, Bhagavatheswaran; Ganesan, Vijeya

    2010-01-01

    Moyamoya disease describes a cerebral arteriopathy characterized by stenosis or occlusion of the terminal internal carotid and/or the proximal middle cerebral arteries. We report a female child with trisomy 21 and bilateral moyamoya disease who presented, unusually, with a presumed perinatal cerebral infarct. The clinical, radiological, and…

  19. Prehospital use of continuous positive airway pressure (CPAP) for presumed pulmonary edema: A preliminary case series

    Microsoft Academic Search

    Joshua M. Kosowsky; Steven L. Stephanides; Richard D. Branson; Michael R. Sayre

    2001-01-01

    Objective. To describe the prehospital use of a continuous positive airway pressure (CPAP) system for the treatment of acute respiratory failure presumed to be due to cardiogenic pulmonary edema. Methods. Prospective case-series analysis. Paramedics administered CPAP via face mask at 10 cm H2O to patients believed to be in cardiogenic pulmonary edema and in imminent need of endotracheal intubation (ETI).

  20. [Dental anatomy of dogs].

    PubMed

    2014-12-01

    The aim of the research was to investigate dog teeth anatomy as animal model for study of etiopathogenesis of caries disease and physiological tooth wear in human. After examining the dog's dental system, following conclusions were drawn: the dog has 42 permanent teeth, which are distributed over the dental arches not equally, and so the upper dentition consists of 20, and the lower of 22 teeth. The largest are considered upper fourth premolar and lower first molars, which are called discordant teeth. Between discordant teeth and fangs a dog has an open bite, which is limited to the top and bottom conical crown premolar teeth. Thus, in the closed position of the jaws, behind this occlusion is limited by discordant teeth, just in contact are smaller in size two molars. Only large dog's molars in a valid comparison can be likened to human molars, which allows us to use them in an analog comparison between them with further study of the morphological features ensure durability short-crown teeth and their predisposition to caries. PMID:25617107

  1. Dog saliva – an important source of dog allergens

    PubMed Central

    Polovic, N; Wadén, K; Binnmyr, J; Hamsten, C; Grönneberg, R; Palmberg, C; Milcic-Matic, N; Bergman, T; Grönlund, H; van Hage, M; Crameri, Reto

    2013-01-01

    Background Allergy to dog (Canis familiaris) is a worldwide common cause of asthma and allergic rhinitis. However, dander extract in routine diagnostics is not an optimal predictor of IgE-mediated dog allergy. Our objective was to evaluate saliva as an allergen source for improved diagnostics of allergy to dog. Methods IgE-binding proteins in dog saliva and dander extract were analysed by immunoblot and mass spectrometry (LC-MS/MS) using pooled or individual sera from dog-allergic patients (n = 13). Sera from 59 patients IgE positive to dander and 55 patients IgE negative to dander but with symptoms to dog were analysed for IgE against saliva and dander by ELISA. Basophil stimulation with dog saliva and dander extract was measured by flow cytometry among three dog-allergic patients. Additionally, IgE-binding protein profiles of saliva from different breeds were investigated by immunoblot. Results Greater number and diversity of IgE-binding proteins was found in saliva compared to dander extract and varied among dog breeds. In saliva, Can f 1, 2, 3 and 6 were identified but also four new saliva allergen candidates. The majority of the 59 dog dander–positive sera (n = 44) were IgE positive to dog saliva. Among patients IgE negative to dander, but with symptoms to dog, 20% were IgE positive to saliva. The biological activity of saliva was confirmed by basophil degranulation. Conclusions Dog saliva is an allergen source for improved diagnostics of dog allergy. The IgE-binding protein profile of saliva from different dogs varies. PMID:23464525

  2. Clinical and serological response of wild dogs (Lycaon pictus) to vaccination against canine distemper, canine parvovirus infection and rabies.

    PubMed

    van Heerden, J; Bingham, J; van Vuuren, M; Burroughs, R E J; Stylianides, E

    2002-03-01

    Wild dogs Lycaon pictuis (n = 8) were vaccinated 4 times against canine distemper (n = 8) (initially with inactivated and subsequently with live attenuated strains of canine distemper) and canine parvovirus infection (n = 8) over a period of 360 days. Four of the wild dogs were also vaccinated 3 times against rabies using a live oral vaccine and 4 with an inactivated parenteral vaccine. Commercially-available canine distemper, canine parvovirus and parenteral rabies vaccines, intended for use in domestic dogs, were used. None of the vaccinated dogs showed any untoward clinical signs. The inactivated canine distemper vaccine did not result in seroconversion whereas the attenuated live vaccine resulted in seroconversion in all wild dogs. Presumably protective concentrations of antibodies to canine distemper virus were present in all wild dogs for at least 451 days. Canine parvovirus haemagglutination inhibition titres were present in all wild dogs prior to the administration of vaccine and protective concentrations persisted for at least 451 days. Vaccination against parvovirus infection resulted in a temporary increase in canine parvovirus haemagglutination inhibition titres in most dogs. Administration of both inactivated parenteral and live oral rabies vaccine initially resulted in seroconversion in 7 of 8 dogs. These titres, however, dropped to very low concentrations within 100 days. Booster administrations resulted in increased antibody concentrations in all dogs. It was concluded that the vaccines were safe to use in healthy subadult wild dogs and that a vaccination protocol in free-ranging wild dogs should at least incorporate booster vaccinations against rabies 3-6 months after the first inoculation. PMID:12088076

  3. Dog by a Log Cabin 

    E-print Network

    Unknown

    2011-09-05

    The domestic dog, Canis lupus familiaris, plays many roles in the lives of humans. Additionally, the dog is recognized for its potential as a model for many human hereditary diseases. Thus, the genetics and genomics of the dog are being studied...

  4. Black-Tailed Prairie Dog

    USGS Multimedia Gallery

    Black-tailed prairie dogs are quite susceptible to sylvatic plague, but a new plague vaccine put in their food shows significant promise in the laboratory. The prairie dogs transmit the disease to endangered black-footed ferrets, who eat the prairie dogs and are also quite susceptible to the disease...

  5. Biting dogs in Rome (Italy)

    Microsoft Academic Search

    L. Maragliano; G. Ciccone; C. Fantini; C. Petrangeli; G. Saporito; M. Di Traglia; E. Natoli

    2007-01-01

    We present data on dog biting events which occurred in Rome and were recorded by the Public Dog Shelter and Veterinary Hospital of Rome. In Italy the control of rabies is regulated by Presidential Decree. Recently, the endorsement of a National Law, aimed at the prevention of dog and cat straying, has greatly modified the relationship with, and the management

  6. Methaemoglobin reductase deficiency in dogs

    Microsoft Academic Search

    J. W. Harvey; R. R. King; C. R. Berry; J. T. Blue

    1991-01-01

    Erythrocyte methaemoglobin reductase deficiency is described in a toy Alaskan Eskimo dog, a miniature poodle dog and a cocker\\/poodle cross dog. Blood methaemoglobin contents ranged from 19% to 36% of total haemoglobin, with methaemoglobin reductase values between 13% and 33% of normal. There appeared to be a negative linear correlation between erythrocyte methaemoglobin content and methaemoglobin reductase activity. A single

  7. Salmonellosis in apparently healthy dogs.

    PubMed

    Shimi, A; Keyhani, M; Bolurchi, M

    1976-02-01

    When rectal swabs were examined from 672 dogs in Tehran, Iran, 52 (7-7 per cent) yielded Salmonellae of 20 different serotypes. The 672 dogs examined comprised 472 household pets, 181 kennel dogs and 19 strays. Tehy showed an incidence of 4-4 per cent, 15-5 per cent and 15-8 per cent respectively. PMID:1258307

  8. The "Big Dog-Puppy Dog" Analogy for Resonance

    NASA Astrophysics Data System (ADS)

    Silverstein, Todd P.

    1999-02-01

    The "big dog-puppy dog" analogy is a wry visual scheme that helps to explain the nature of resonance structures, delocalized p bonds, and fractional bond orders and formal charges. In this analogy, puppy dogs are restricted to a specific dog run; they represent s-bond electron pairs. Big dogs are allowed to roam freely over several consecutive dog runs; they represent delocalized p-bond electron pairs. By adding a bunny rabbit who is chased by the big dog, the analogy can be expanded to account for delocalized formal charge in a resonance hybrid. This analogy presents a vivid, humorous picture that helps to explain some of the key aspects of resonance.

  9. Dog Feeding and By: Jennifer Cooper

    E-print Network

    Selmic, Sandra

    Dog Feeding and Care By: Jennifer Cooper Trista Anderson Animal Science 405 Applied Animal://www.aspca.org/pet-care/ dog-care/feeding-your- puppy.html http://www.aspca.org/pet-care/ dog-care/dog-care-newborn- puppy-care.html http://www.aspca.org/pet-care/ dog-care/feeding-your-adult- dog.html http://www.hsus.org/pets/ pet_care/dog

  10. Experimental parvovirus infection in dogs.

    PubMed Central

    Potgieter, L N; Jones, J B; Patton, C S; Webb-Martin, T A

    1981-01-01

    Five eight week old dogs were inoculated orally and intranasally with cell culture origin canine parvovirus. Three dogs became depressed and anorectic and developed a mild (one dog) to severe diarrhea five days postinfection. The remaining dogs had subclinical infections but developed a lymphopenia followed by a transient lymphocytosis. The ill dogs developed mild (one dog) to severe neutropenia and a moderate lymphopenia. One died nine days postinfection. Recovery was associated with cessation of viral excretion and with lymphocytosis and antibody production. Two of three dogs challenged intragastrically developed mild clinical signs and a moderate panleukopenia four to eight days postinfection. The pathological changes of the experimental disease were very similar to that of spontaneous disease. Bone marrow changes included a severe granulocytic and mild erythroid depletion. The pathogenesis of canine parvovirus infection is discussed. Images Fig. 4. Fig. 5. Fig. 6. PMID:7340906

  11. Experimental parvovirus infection in dogs.

    PubMed

    Potgieter, L N; Jones, J B; Patton, C S; Webb-Martin, T A

    1981-07-01

    Five eight week old dogs were inoculated orally and intranasally with cell culture origin canine parvovirus. Three dogs became depressed and anorectic and developed a mild (one dog) to severe diarrhea five days postinfection. The remaining dogs had subclinical infections but developed a lymphopenia followed by a transient lymphocytosis. The ill dogs developed mild (one dog) to severe neutropenia and a moderate lymphopenia. One died nine days postinfection. Recovery was associated with cessation of viral excretion and with lymphocytosis and antibody production. Two of three dogs challenged intragastrically developed mild clinical signs and a moderate panleukopenia four to eight days postinfection. The pathological changes of the experimental disease were very similar to that of spontaneous disease. Bone marrow changes included a severe granulocytic and mild erythroid depletion. The pathogenesis of canine parvovirus infection is discussed. PMID:7340906

  12. Dog bite injuries

    Microsoft Academic Search

    Louise Marsh; John Langley; Robin Gauld

    Aims To describe the extent of the dog bite problem in New Zealand for the period 1989 to 2001. Methods Fatalities and cases requiring public-hospital treatment identified from the New Zealand Health Information Service databases. Results There was one fatality and 3119 hospitalisations, an average of 240 per year. Those most at risk were males and children under 9 years

  13. Dogs and Their Owners

    NSDL National Science Digital Library

    Science Update

    2004-05-03

    If you look at drawings of people and their dogs, you'll notice they're often drawn alike: for instance, saggy-faced bulldogs with saggy-faced old men. But is the stereotype really true? A recent study looked into it.

  14. Cancer-Sniffing Dogs

    NSDL National Science Digital Library

    American Association for the Advancement of Science (; )

    2006-02-10

    Cancer-Sniffing Dogs is a Science Update which gives introduces the concept that diseases might be identified by examining the chemicals which are on a patients breath. A more in depth discussion of disease diagnosis by sampling a patients breath is given as well as links to other articles further reading.

  15. Glow Dog Glow

    E-print Network

    Hacker, Randi

    2011-08-17

    Broadcast Transcript: South Korean researchers, ever striving to be top in science, have cloned a glow-in-the-dark dog. The little beagle was engineered by inserting genes from species--like jellyfish--that produce fluorescent proteins. The gene...

  16. The Black Dog Mystery

    Microsoft Academic Search

    Sue Hanley

    The black dog - a term for depression which has very old origins, but which has been made famous in more recent times by Britain's World War II leader, Sir Winston Churchill, referring to his own periods of gloom. Sir Winston was a great rhetorician, but he did not invent the term. Schooled in the classics as he and his

  17. Zen Hot Dog Molecules

    NASA Astrophysics Data System (ADS)

    Ryan, Dennis

    2009-04-01

    Substituted cycloalkanes with one branch illustrating each topic in an instructional unit can serve as summaries or reviews in courses of organic chemistry. The hungry Zen master told the hot dog vendor to make him one with everything. You can do the same for your students.

  18. Hot Dog Champ Defeated

    E-print Network

    Hacker, Randi; Tsutsui, William; Bleier, R.H.

    2007-07-25

    Broadcast Transcript: Arthritic jaw? Recent wisdom tooth extraction? The universe saying "It is time"? Whatever. All we know is that Japan's six year domination of Nathan's Famous July 4th Hot Dog Eating contest at Coney Island came to an end...

  19. Zen Hot Dog Molecules

    ERIC Educational Resources Information Center

    Ryan, Dennis

    2009-01-01

    Substituted cycloalkanes with one branch illustrating each topic in an instructional unit can serve as summaries or reviews in courses of organic chemistry. The hungry Zen master told the hot dog vendor to make him one with everything. You can do the same for your students.

  20. Prevention and Treatment of Dog Bites

    Microsoft Academic Search

    R. JOHN PRESUTTI

    2001-01-01

    Almost one half of all dog bites involve an animal owned by the victim's family or neighbors. A large percentage of dog bite victims are children. Although some breeds of dogs have been identified as being more aggressive than other breeds, any dog may attack when threatened. All dog bites carry a risk of infection, but immediate copious irrigation can

  1. General Knowledge Dog 2013 American Red Cross Dog First Aid = ARC Ohio State Resource Handbook = Ohio ST

    E-print Network

    New Hampshire, University of

    and your dog o A favorite toy o A sturdy, well-ventilated carrier Make an initial evaluation if dog1 General Knowledge ­ Dog 2013 American Red Cross Dog First Aid = ARC Ohio State Resource Handbook = Ohio ST AKC Dog Care & Training = AKC Dog Care AKC Complete Dog Boo k = AKC Complete Dog AKC Complete

  2. Effects of a synbiotic on fecal quality, short-chain fatty acid concentrations, and the microbiome of healthy sled dogs

    PubMed Central

    2013-01-01

    Background Sled dogs commonly suffer from diarrhea. Although multiple etiologies exist there are limited field studies using synbiotics as a supplement to prevent or treat diarrhea. The objective of this study was to examine alterations in fecal quality, short-chain fatty acids (SCFA), and the fecal microbiome in two groups of training sled dogs fed a synbiotic or microcrystalline cellulose placebo. Twenty clinically healthy training sled dogs randomized into two cohorts (9 synbiotic-fed, 8 placebo-fed) for a 6 week prospective study were examined. Fecal pH and fecal short chain fatty acid (SCFA) concentrations were measured and tag-encoded FLX 16S rDNA amplicon pyrosequencing (bTEFAP) and quantitative real-time PCR were performed at baseline (10 d prior to the study) and after 2 weeks of treatment with a total treatment time of 6 weeks. Fecal scores for all dogs were assessed at baseline and every day for 6 wk after initiation of treatment. Results Alterations in the fecal microbiome were observed with a significant rise in Lactobacillaceae in the synbiotic group (P?=?0.004) after 2 wk of treatment. A positive correlation was found between Lactobacillaceae and overall butyrate concentration (R?=?0.62, p?=?0.011) in all dogs. After 5 wk of treatment, there was an improved fecal score and fewer days of diarrhea (?2?=?5.482, P?=?0.019) in the dogs given synbiotic, which coincided with a presumed contagious outbreak shared by all dogs in the study. Conclusions Use of this synbiotic results in an increase in presumed beneficial bacterial flora of the host colon which was associated with a decrease in the prevalence of diarrhea in training sled dogs. PMID:24313995

  3. New Hampshire Guide 4-H Dog Shows

    E-print Network

    New Hampshire, University of

    New Hampshire Guide to 4-H Dog Shows UNH Cooperative Extension 4-H Youth Development Moiles House cooperating. #12;NH Guide to 4-H Dog Shows i Table of Contents INTRODUCTION .................................................................................................................................2 Purpose of the 4-H Dog Project

  4. Kennel enrichment: exercise and socialization of dogs.

    PubMed

    Coppinger, R; Zuccotti, J

    1999-01-01

    In the last 50 years, there has been a growing need for storage and management systems for the production and maintenance of large numbers of dogs. Unwanted dogs and strays, detained in kennels, stay for various lengths of time. Large kennels also produce dogs for sale as companion animals, for the service dog industry (police and guide dogs), for biomedical research, and for use by dog food companies. Across the United States, literally tens of thousands of dogs are born in kennels and spend their lives in kennels. The laboratory dog, the kennel dog, the service dog, and the companion dog are in an evolutionary transition period, accompanied by concomitant adaptation to stresses signaled by a high frequency of genetic disease and behavioral abnormalities. For kennel enrichment programs, such as socialization and exercise, the modern kenneled dog is a genetically moving target. Specific recommendations apply neither to all breeds nor to the variations within a single breed. PMID:16363933

  5. Estimated prevalence and patterns of presumed osteoporosis among older Americans based on Medicare data

    Microsoft Academic Search

    H. Cheng; L. C. Gary; J. R. Curtis; K. G. Saag; M. L. Kilgore; M. A. Morrisey; R. Matthews; W. Smith; H. Yun; E. Delzell

    2009-01-01

    Introduction  Estimates of osteoporosis (OP) prevalence based on bone mineral density testing and fracture occurrence may be imprecise for\\u000a small demographic groups. Medicare data are a useful supplemental source of information on OP.\\u000a \\u000a \\u000a \\u000a Methods  We studied people ages ?65 years covered by Medicare 2005. Cases of presumed OP were beneficiaries with physician services\\u000a or inpatient claims for OP or for an associated fracture

  6. Successful Colchicine Therapy in a Patient With Follicular Bronchiolitis Presumed to Be Asthma.

    PubMed

    Goksel, Ozlem; Nart, Deniz; Ergonul, Ayse Gul; Sever, Fidan; Goksel, Tuncay

    2015-07-01

    Follicular bronchiolitis (FB) is a rare small-airway pathology that is associated mainly with connective tissue diseases. This case report presents a new, diagnosed, different airway disease in a non-smoker with rheumatoid arthritis in remission who was treated for presumed asthma, but was not controlled. She was ultimately diagnosed with FB after video-assisted thoracoscopic surgery. The clinical findings of FB were controlled successfully by colchicine after she did not respond to systemic steroid therapy. This is the first case report of FB associated with rheumatoid arthritis that responded to colchicine. PMID:25587165

  7. Unreported dog bites in children.

    PubMed

    Beck, A M; Jones, B A

    1985-01-01

    In 1981, more than 3,200 Pennsylvania children, ages 4 to 18 years, were surveyed about their dog bite histories and attitudes toward animals. Dog bites were much more common than previously reported: 45 percent of children had been bitten during their lifetimes, and 15.5 percent had been bitten in 1980, more than 36 times the rate reported to health authorities. In 1980, the highest bite rate occurred among children 7-12 years old (20 percent). Children were bitten more frequently by the dogs owned by their neighbors, followed by their own dogs, than by strays or by dogs whose owners were not known. Boys were bitten twice as frequently as girls by neighbors' dogs and strays; the bite rates from family dogs were identical in boys and girls. Despite the high bite rates, being bitten was not significantly associated, in most groups of children studied, with a dislike of dogs. These positive attitudes toward dogs may lead to inadequate precautions against bites and to biases in the reporting of bites to health authorities. PMID:3923540

  8. Presumed late recurrence of Acanthamoeba keratitis exacerbated by exposure to topical corticosteroids

    PubMed Central

    Patel, Dipika V; McGhee, Charles NJ

    2013-01-01

    A 28-year-old female with a history of contact lens wear presented with a 1 week history of pain and photophobia in her left eye. In vivo confocal microscopy (IVCM) and corneal scrape confirmed the diagnosis of Acanthamoeba keratitis (AK) which was treated with intensive topical propamidine isethionate (0.1%) and chlorhexidine (0.02%) with tapering dosage over 11 months. Five years after complete resolution of AK and cessation of all contact lens wear, the subject presented to her optometrist with a history of ocular discomfort and mild photophobia. Without further investigation she was prescribed topical corticosteroids. Three weeks later she presented with pain and reduced vision in the left eye. Slit-lamp examination revealed focal, inferior corneal stromal edema. IVCM confirmed widespread Acanthamoeba cysts. Treatment with topical polyhexamethylene biguanide (PHMB) 0.02% and propamidine isethionate 0.1% resulted in resolution of the AK. Despite an initially mild AK, this subject presumably retained viable Acanthamoeba cysts in her cornea 5 years after the initial episode. This report highlights the importance of caution when using corticosteroids in patients with a previous history of AK, even in the relatively distant past. Patients with AK should be warned regarding the risks of recurrence following presumed resolution. PMID:24391372

  9. Presumed late recurrence of Acanthamoeba keratitis exacerbated by exposure to topical corticosteroids.

    PubMed

    Patel, Dipika V; McGhee, Charles Nj

    2013-09-01

    A 28-year-old female with a history of contact lens wear presented with a 1 week history of pain and photophobia in her left eye. In vivo confocal microscopy (IVCM) and corneal scrape confirmed the diagnosis of Acanthamoeba keratitis (AK) which was treated with intensive topical propamidine isethionate (0.1%) and chlorhexidine (0.02%) with tapering dosage over 11 months. Five years after complete resolution of AK and cessation of all contact lens wear, the subject presented to her optometrist with a history of ocular discomfort and mild photophobia. Without further investigation she was prescribed topical corticosteroids. Three weeks later she presented with pain and reduced vision in the left eye. Slit-lamp examination revealed focal, inferior corneal stromal edema. IVCM confirmed widespread Acanthamoeba cysts. Treatment with topical polyhexamethylene biguanide (PHMB) 0.02% and propamidine isethionate 0.1% resulted in resolution of the AK. Despite an initially mild AK, this subject presumably retained viable Acanthamoeba cysts in her cornea 5 years after the initial episode. This report highlights the importance of caution when using corticosteroids in patients with a previous history of AK, even in the relatively distant past. Patients with AK should be warned regarding the risks of recurrence following presumed resolution. PMID:24391372

  10. Inflammatory autoimmune neuropathy, presumably induced by bortezomib, in a patient suffering from multiple myeloma.

    PubMed

    Schmitt, Stefan; Goldschmidt, H; Storch-Hagenlocher, B; Pham, M; Fingerle-Rowson, G; Ho, A D; Neben, K

    2011-06-01

    Bortezomib is a proteasome inhibitor demonstrating substantial activity in multiple myeloma. One of its key toxicities is peripheral neuropathy, which is reversible in most patients. The possibility that bortezomib might in rare cases induce severe neuropathies by auto-inflammatory mechanisms remains controversial. We report here the case of a 65-year-old female myeloma patient who was initially treated with bortezomib, doxorubicin, and dexamethasone (PAD). At the end of the second cycle of PAD, the patient presented with a rapid and severe onset of paresis of the left arm, accompanied by progressive sensory neuropathy and increasing neuropathic pain. After an extensive neurological work-up, including electrophysiological and laboratory evaluations as well as magnet resonance tomography imaging, we diagnosed an inflammatory autoimmune neuropathy, presumably induced by bortezomib, with accentuation of the left arm nerve plexus. We subsequently initiated regular treatment with polyvalent immunoglobulins, which gradually improved the neurological symptoms. In conclusion, the identification of an inflammatory autoimmune neuropathy, presumably associated with bortezomib, is a rare but important complication. An extensive neurological examination should be performed in patients who develop severe or unusual sensory or motor deficits under therapy with bortezomib, so as to differentiate autoimmune from toxic neuropathies, as therapeutic strategies differ for each. PMID:21553020

  11. Field evaluation of two bait delivery systems for the oral immunization of dogs against rabies in Tunisia.

    PubMed

    Matter, H C; Schumacher, C L; Kharmachi, H; Hammami, S; Tlatli, A; Jemli, J; Mrabet, L; Meslin, F X; Aubert, M F; Neuenschwander, B E; Hicheri, K E

    1998-04-01

    Two bait delivery systems for the oral immunization of dogs against rabies were tested in small scale field trials in a semi-rural area in Tunisia: bait delivery to owned dogs during door to door visits of households (door to door baiting) and distribution of baits on transect lines (transect line baiting). A prototype bait (DBL2) configured for industrial production and containing either sulfadimethoxine (SDM) as a systemic marker or Rhodamine B as a topical marker was used. The overall proportion of dogs which took a bait and presented topical marker staining after door to door baiting was 59.1%. The total time and costs spent per bait accepting dog averaged 34 person minutes and US$4, respectively. Unconsummated baits were readily recovered. No unprotected human contacts with baits were recorded. Door to door baiting is a very specific but time-consuming method that enables a safe administration of vaccine baits to owned dogs. For transect line baiting, baits were distributed at a density of ca 3000 baits per km2 along double transect lines. Baits were recovered after 20 h. According to the proportion of SDM positive serum samples, 24.1% of owned dogs in the baiting area had consumed baits. Of all owned and ownerless dogs, presumably free-roaming during transect line baiting, > 40% had consumed baits. The total time and costs spent per bait accepting dog averaged 48 person minutes and ca US$20, respectively. The household census revealed 32 direct human contacts with the bait matrix which corresponds to 1.4% of inhabitants. Placing baits on transect lines gives the possibility to vaccinate dogs not accessible by vaccination systems which base on dog owner participation. However, the method is not specific, less safe than other systems, not easily accepted by the human population, and costly. PMID:9562683

  12. Do Dog Behavioral Characteristics Predict the Quality of the Relationship between Dogs and Their Owners?

    PubMed Central

    Hoffman, Christy L.; Chen, Pan; Serpell, James A.; Jacobson, Kristen C.

    2014-01-01

    This paper explores whether dog behavioral characteristics predict the quality of the relationship between dogs and their owners (i.e., owner attachment to dog), and whether relations between dog behavior and owner attachment are moderated by demographic characteristics. In this study, N = 92 children and N = 60 adults from 60 dog-owning families completed questionnaires about their attachment to their pet dog, their level of responsibility for that dog, and their general attitudes toward pets. They also rated their dogs on observable behavioral characteristics. Individuals who held positive attitudes about pets and who provided much of their dog’s care reported stronger attachments to their dogs. The strength of owners’ attachments to their dogs was associated with dog trainability and separation problems. Relationships between owner attachment and both dog excitability and attention-seeking behavior were further moderated by demographic characteristics: for Caucasians but not for non-Caucasians, dog excitability was negatively associated with owner attachment to dog; and for adults, dog attention-seeking behavior was positively associated with owner attachment, but children tended to be highly attached to their dogs, regardless of their dogs’ attention-seeking behaviors. This study demonstrates that certain dog behavioral traits are indeed associated with the strength of owners’ attachments to their dogs. PMID:25685855

  13. Communal nursing in prairie dogs

    Microsoft Academic Search

    J. L. Hoogland; R. H. Tamarin; C. K. Levy

    1989-01-01

    Within a natural population of blacktailed prairie dogs (Cynomys ludovicianus), 68% of sampled juveniles received milk from foster mothers via communal nursing (Table 1). In proximate terms, communal nursing may result because prairie dog mothers seem unable to discriminate between their own and others' offspring. In ultimate terms, both indirect selection and reduced predation on juveniles resulting from the formation

  14. Prairie Dog Released from Trap

    USGS Multimedia Gallery

    A prairie dog returns to its burrow in Wind Cave National Park after scientists free it from a trap. The animal is part of a field test to determine the effectiveness of a USGS-developed oral sylvatic plague vaccine (SPV). This prairie dog was previously tagged, and its blood, hair, and whisker samp...

  15. A dog in the fight

    Microsoft Academic Search

    Holly Hughes

    2010-01-01

    Holly Hughes’ “A Dog in the Fight” is a queer and feminist literary performance that models a feminist politics of performance that stands as alternative to performances of power that come from the officially anointed space of politics. In this piece, Hughes meditates on the queer relationship between US Presidents and their faithful companions, their dogs. Refusing to jump through

  16. Factors associated with dog ownership and contact with dogs in a UK community

    Microsoft Academic Search

    Carri Westgarth; Gina L Pinchbeck; John WS Bradshaw; Susan Dawson; Rosalind M Gaskell; Robert M Christley

    2007-01-01

    BACKGROUND: Dogs are popular pets in many countries. Identifying differences between those who own dogs or have contact with dogs, and those who do not, is useful to those interested in the human-animal bond, human health and for provision of veterinary services. This census-based, epidemiological study aimed to investigate factors associated with dog ownership and contact with dogs, in a

  17. Comparison of transducer placement sites for Doppler echocardiography in dogs with subaortic stenosis.

    PubMed

    Lehmkuhl, L B; Bonagura, J D

    1994-02-01

    Effects of transducer placement site and various operators on Doppler echocardiographic measures were evaluated in 12 dogs with subaortic stenosis. Dogs sedated by IV administration of acepromazine and buprenorphine were examined by 2 observers. Maximal aortic velocity and aortic velocity time integral were determined from Doppler aortic velocity spectra recorded, using a 1.9-MHz continuous wave nonimaging transducer placed at 3 echocardiographic sites: left ventricular apex (LA), suprasternal notch (SSN), and subcostal (SC). Doppler-estimated left ventricular-to-aortic pressure gradients were calculated from the traced velocity spectra by application of the modified Bernoulli equation. Each observer recorded high-quality Doppler spectral signals in all dogs from the SC and LA transducer sites and in 83% of dogs from the SSN window. Mean values for maximal aortic velocity and velocity time integral differed among sites (P < 0.05), but not between observers. Maximal velocity and velocity time integral measured from the SC transducer site were higher than those measured from the SSN or LA positions. Presumably, SC transducer placement provided the highest aortic velocities because of optimal alignment with aortic outflow. The maximal pressure gradient estimated from SC velocities exceeded SSN values by 27 mm of Hg and LA measurements by 38 mm of Hg. In this study, the optimal site for the Doppler echocardiographic detection of subaortic stenosis and assessment of this lesion's hemodynamic importance in most affected dogs was the SC position. PMID:8172406

  18. Hypoadrenocorticism in a kindred of Pomeranian dogs

    PubMed Central

    Mooney, Erin T.; Hammond, Tara N.; Mahony, Orla M.

    2015-01-01

    Three adult Pomeranian dogs, full siblings from 2 litters, were diagnosed with primary hypoadrenocorticism following onset of hypoadrenal crisis. Review of the family history revealed the dogs’ maternal grandmother also had hypoadrenocorticism. All 4 dogs were pedigree-certified by the American Kennel Club. An inherited basis for hypoadrenocorticism is proposed in these Pomeranian dogs. PMID:25565713

  19. Hunting Dogs in the Lowland Neotropics

    Microsoft Academic Search

    Jeremy Koster

    2009-01-01

    Once absent in much of Amazonia, dogs are now commonly used for hunting throughout the lowland Neotropics. Although some ethnographers have questioned their usefulness, dogs are particularly effective in pursuits of several mammalian prey species. The return rates of hunting with dogs appear to compare favorably with those of hunting with firearms, and dogs may be especially beneficial in anthropogenic

  20. Prevalence of Giardia and Cryptosporidium species in dog park attending dogs compared to non-dog park attending dogs in one region of Colorado

    Microsoft Academic Search

    Andrea Wang; Rebecca Ruch-Gallie; Valeria Scorza; Philip Lin; Michael R. Lappin

    Dog parks are very popular in urban areas, but there are no current studies attempting to correlate visits to dog parks and risk of colonization by enteric parasites. The purpose of this study was to determine whether dog park visitation is associated with an increased prevalence of enteric parasites or an increase in prevalence of gastrointestinal signs in dogs in

  1. Correspondence Dog as an Outgroup to Human

    E-print Network

    Gerstein, Mark

    Correspondence Dog as an Outgroup to Human and Mouse Gerton Lunter In a recent contribution to PLo to human and dog [1], in disagreement with several recent studies suggesting that the dog is an outgroup to the primate­rodent clade [2,3]. The authors' arguments rest on a variety of analyses of human, mouse, and dog

  2. Dog Obedience, Showmanship, and Contest Guide

    E-print Network

    New Hampshire, University of

    Dog Obedience, Showmanship, and Contest Guide 4-H 1202 Revised January 2013 Purpose Obedience and showmanship contests provide an opportunity for you to demonstrate how well you've trained your dog and how you and your dog work as a team. Eligibility You may enter 4-H dog obedience and showmanship trials

  3. Hypoadrenocorticism in a kindred of Pomeranian dogs.

    PubMed

    Mooney, Erin T; Hammond, Tara N; Mahony, Orla M

    2015-01-01

    Three adult Pomeranian dogs, full siblings from 2 litters, were diagnosed with primary hypoadrenocorticism following onset of hypoadrenal crisis. Review of the family history revealed the dogs' maternal grandmother also had hypoadrenocorticism. All 4 dogs were pedigree-certified by the American Kennel Club. An inherited basis for hypoadrenocorticism is proposed in these Pomeranian dogs. PMID:25565713

  4. Do dogs ( Canis familiaris ) show contagious yawning?

    Microsoft Academic Search

    Aimee L. Harr; Valerie R. Gilbert; Kimberley A. Phillips

    2009-01-01

    We report an experimental investigation into whether domesticated dogs display contagious yawning. Fifteen dogs were shown\\u000a video clips of (1) humans and (2) dogs displaying yawns and open-mouth expressions (not yawns) to investigate whether dogs\\u000a showed contagious yawning to either of these social stimuli. Only one dog performed significantly more yawns during or shortly\\u000a after viewing yawning videos than to

  5. Consenting options for posthumous organ donation: presumed consent and incentives are not favored

    PubMed Central

    2012-01-01

    Background Posthumous organ procurement is hindered by the consenting process. Several consenting systems have been proposed. There is limited information on public relative attitudes towards various consenting systems, especially in Middle Eastern/Islamic countries. Methods We surveyed 698 Saudi Adults attending outpatient clinics at a tertiary care hospital. Preference and perception of norm regarding consenting options for posthumous organ donation were explored. Participants ranked (1, most agreeable) the following, randomly-presented, options from 1 to 11: no-organ-donation, presumed consent, informed consent by donor-only, informed consent by donor-or-surrogate, and mandatory choice; the last three options ± medical or financial incentive. Results Mean(SD) age was 32(9) year, 27% were males, 50% were patients’ companions, 60% had???college education, and 20% and 32%, respectively, knew an organ donor or recipient. Mandated choice was among the top three choices for preference of 54% of respondents, with an overall median[25%,75%] ranking score of 3[2,6], and was preferred over donor-or-surrogate informed consent (4[2,7], p?presumed consent (7[3,10], p?presumed consent system was the least preferred, 3) there was no difference between preference and perception of norm in consenting systems ranking, and 4) financial (especially in females) and medical (especially in males) incentives reduced preference. PMID:23173834

  6. Analysis of PDE6D and PDE6G genes for generalised progressive retinal atrophy (gPRA) mutations in dogs

    PubMed Central

    Dekomien, Gabriele; Epplen, Joerg T

    2003-01-01

    The ? and ? subunits of the cGMP-phosphodiesterase (PDE6D, PDE6G) genes were screened in order to identify mutations causing generalised progressive retinal atrophy (gPRA) in dogs. In the PDE6D gene, single nucleotide polymorphisms (SNP) were observed in exon 4, in introns 2 and 3 and in the 3' untranslated region (UTR) of different dog breeds. In the coding region of the PDE6G gene, exclusively healthy Labrador Retrievers showed an A ? G transition in exon 4 without amino acid exchange. SNP were also observed in introns 1 and 2 in different dog breeds. The different SNP were used as intragenic markers to investigate the involvement of both genes in gPRA. The informative substitutions allowed us to exclude mutations in the PDE6D and PDE6G genes as causing retinal degeneration in 15 of the 22 dog breeds with presumed autosomal recessively transmitted (ar) gPRA. PMID:12927076

  7. Outcome of occult uterine leiomyosarcoma after surgery for presumed uterine fibroids: a systematic review.

    PubMed

    Pritts, Elizabeth A; Parker, William H; Brown, Jubilee; Olive, David L

    2015-01-01

    There is concern that morcellation of occult leiomyosarcomas during surgery to treat presumed myomas may substantially worsen patient outcome. We reviewed the existing medical literature to better understand whether such a risk was demonstrable and, if so, what the magnitude of that risk might be. We identified 4864 articles initially, of which 60 were evaluated in full. Seventeen were found to have outcomes information and are included in this review. Six studies addressed the question of whether morcellation of occult leiomyosarcomas resulted in inferior outcomes as compared with en bloc uterine and tumor removal. In these 6 studies, results suggested that en bloc removal may result in improved survival and less recurrence; however, the data are highly biased and of poor quality. There is no reliable evidence that morcellation, power or otherwise, substantially results in tumor upstaging. There is no evidence from these 17 studies that power morcellation differs in any way from other types of morcellation or even simple myomectomy insofar as patient outcome. Whether electromechanical morcellation poses a unique danger to the patient with occult leiomyosarcoma is an unanswered question and one clearly in need of more extensive investigation before conclusions are drawn and policies created. PMID:25193444

  8. Testosterone and 5HIAA in dogs with intraspecific aggression 

    E-print Network

    Haug, Lore I

    2003-01-01

    Intraspecific aggression is a common problem in dogs, with such aggression typically due to dominance, fear, and/or territoriality. Some dogs appear to perceive the mere presence of another dog as a challenge or threat. These dogs often show...

  9. 4-H Dog Project Record Grade in Date

    E-print Network

    Tullos, Desiree

    4-H Dog Project Record Grade in Date Name___________________________________ Boy _____ Girl a photo of you & your dog in this space. Information about Your Dog My dog's name is _____________________________________________________________ Sex _______________ Breed_______________________________________________ Purebred Mixed Breed Is your

  10. Domesticated Dogs’ (Canis familiaris) Response to Dishonest Human Points

    E-print Network

    2010-01-01

    choice behavior and whether dogs, like human children, havechoice behavior and whether dogs, like human children, havehuman gesturing, namely static points, in dogs’ choice behavior. In particular, we explored whether dogs, like human children (

  11. Do dogs (Canis familiaris) show contagious yawning?

    PubMed

    Harr, Aimee L; Gilbert, Valerie R; Phillips, Kimberley A

    2009-11-01

    We report an experimental investigation into whether domesticated dogs display contagious yawning. Fifteen dogs were shown video clips of (1) humans and (2) dogs displaying yawns and open-mouth expressions (not yawns) to investigate whether dogs showed contagious yawning to either of these social stimuli. Only one dog performed significantly more yawns during or shortly after viewing yawning videos than to the open-mouth videos, and most of these yawns occurred to the human videos. No dogs showed significantly more yawning to the open-mouth videos (human or dog). The percentage of dogs showing contagious yawning was less than chimpanzees and humans showing this behavior, and considerably less than a recently published report investigating this behavior in dogs (Joly-Mascheroni et al. in Biol Lett 4:446-448, 2008). PMID:19452178

  12. Why do adult dogs 'play'?

    PubMed

    Bradshaw, John W S; Pullen, Anne J; Rooney, Nicola J

    2015-01-01

    Among the Carnivora, play behaviour is usually made up of motor patterns characteristic of predatory, agonistic and courtship behaviour. Domestic dogs are unusual in that play is routinely performed by adults, both socially, with conspecifics and with humans, and also asocially, with objects. This enhanced playfulness is commonly thought to be a side effect of paedomorphosis, the perpetuation of juvenile traits into adulthood, but here we suggest that the functions of the different types of play are sufficiently distinct that they are unlikely to have arisen through a single evolutionary mechanism. Solitary play with objects appears to be derived from predatory behaviour: preferred toys are those that can be dismembered, and a complex habituation-like feedback system inhibits play with objects that are resistant to alteration. Intraspecific social play is structurally different from interspecific play and may therefore be motivationally distinct and serve different goals; for example, dogs often compete over objects when playing with other dogs, but are usually more cooperative when the play partner is human. The majority of dogs do not seem to regard competitive games played with a human partner as "dominance" contests: rather, winning possession of objects during games appears to be simply rewarding. Play may be an important factor in sociality, since dogs are capable of extracting social information not only from games in which they participate, but also from games that they observe between third parties. We suggest that the domestic dog's characteristic playfulness in social contexts is an adaptive trait, selected during domestication to facilitate both training for specific purposes, and the formation of emotionally-based bonds between dog and owner. Play frequency and form may therefore be an indicator of the quality of dog-owner relationships. PMID:25251020

  13. Identification of telomerase in dog

    E-print Network

    Lyuksyutova, Anna

    2013-02-22

    IDENTIFICATION OF TELOMERASE IN DOG A Senior Honors Thesis by ANNA LYUKSYUTOVA Submitted to the OIYice of Honors Programs It Academic Scholarships Texas A&M University in partial fulfilment of the requirements of the UNIVERSITY UNDERGRADUATE... RESEARCH FELLOWS April 2000 Group: Cell Biology 1 IDENTIFICATION OF TELOMERASE IN DOG A Senior Honors Thesis By ANNA LYUKSYUTOVA Submitted to the Office of Honors Programs 8 Academic Scholarships Texas &M University In partial fulfillment...

  14. VSF Dog Department Entry Form 2014 In order to show your dog(s), you must have completed the Dog Approval/Identification form that was due to your Extension

    E-print Network

    Hayden, Nancy J.

    VSF Dog Department Entry Form 2014 In order to show your dog(s), you must have completed the Dog BE SUBMITTED FOR EACH DOG YOU'RE ENTERING to the UVM Extension Office, 1 Scale Avenue, Suite 55, Rutland, Vermont 05701-4457 ATTN: VSF Dog Department, or scanned and sent as an attachment to mary

  15. [Childhood vaccinations anno 2004. II. The real and presumed side effects of vaccination].

    PubMed

    Rümke, H C; Visser, H K

    2004-02-21

    Vaccinations protect to a high degree against infectious diseases, but may cause side effects. In the Netherlands since 1962 the adverse events following immunizations are registered and analysed by the National Institute of Health and Environment (RIVM). Since 1983 a permanent Committee of the Dutch Health Council reviews adverse events reported to the RIVM. With the so-called killed vaccines the side effects are mainly local (redness, swelling, pain) or general (fever, listlessness, irritability, sleep and eating problems). They are seen mainly after DPT-IPV vaccination against diphtheria, pertussis, tetanus and poliomyelitis. Some side effects occur rarely (collapse reactions, discoloured legs, persistent screaming and convulsions) and very rarely serious neurological events are reported. After MMR vaccination against measles, mumps and rubella, cases of arthritis, thrombocytopenia and ataxia are reported sporadically. Usually, they have a spontaneous recovery. During recent years a scala of diseases or symptoms have been associated with vaccination (presumed side effects). Careful and extensive investigations have shown that such hypotheses could not be supported. Examples are allergic diseases as asthma, diabetes mellitus, multiple sclerosis (after hepatitis B vaccination), autism and inflammatory bowel disease (after MMR vaccination) and sudden infant death syndrome. The total number of cases where at least a possible relation between side effects and vaccination is observed--apart from local reactions and moderate general symptoms--is very rare (about 0.25 per 1000 vaccinations) and does not balance the benefits from vaccination. There appears increasing doubt about the use and safety of vaccinations. More research is needed about the motives of people to choose for and against vaccination. The education about vaccination for parents and professionals who are involved with vaccination has to be improved. Internet can play an important role. PMID:15032089

  16. Lymphocytic ganglioneuritis secondary to intervertebral disc extrusion in a dog.

    PubMed

    Mouradian-Darby, A E; Young, B D; Griffin, J F; Mansell, J; Levine, J M

    2014-09-01

    This study presents a case of lymphocytic ganglioneuritis in a dog secondary to intervertebral disc extrusion that mimicked a peripheral nerve sheath tumour on magnetic resonance imaging. A four-year-old spayed female dachshund with lumbar pain was imaged via magnetic resonance. A?tubular, space-occupying, contrast-enhancing lesion was noted in the right intervertebral foramen at L6 to L7. This was presumed to represent focal enlargement of the right sixth lumbar spinal nerve. A?right-sided haemilaminectomy was performed at L6 to L7 and material that grossly resembled extruded nucleus pulposus was removed. The right L6 dorsal root ganglion, dorsal nerve root and proximal spinal nerve were severely enlarged and a partial thickness biopsy was collected from the dorsal root ganglion. Results of histopathological examination of the submitted tissue samples were consistent with extruded disc material and lymphocytic ganglioneuritis. To the author's knowledge, this is the first published report of lymphocytic ganglioneuritis secondary to intervertebral disc disease in a dog. PMID:24779364

  17. Demography and dog-human relationships of the dog population in Zimbabwean communal lands

    Microsoft Academic Search

    J. R. A. Butler; J. Bingham

    2000-01-01

    Dogs are Zimbabwe's primary vector for rabies, and the majority live in communal lands (traditional agropastoralist rural areas). In 1994, a household questionnaire survey was conducted to provide baseline data on the demography and dog-human relationships of the dogs in the communal lands. The survey showed that all the dogs were owned, and there was no evidence of a feral

  18. Dog recloning from muscle fibroblasts in transgenic cloned beagle: Regeneration of an identical transgenic dog

    Microsoft Academic Search

    So Gun Hong; Hyun Ju Oh; Jung Eun Park; Min Jung Kim; Ji Eun Kim; Goo Jang; Byeong Chun Lee

    2010-01-01

    Dogs (Canis familiaris) share many common genetic diseases with humans and development of dog disease models using a transgenic approach has long been awaited. However, due to the technical difficulty in obtaining fertilizable eggs and the unavailability of embryonic stem cells, no recloned transgenic dog has been generated. Here, we attempted the recloning of dogs by nuclear transfer of canine

  19. Comparative Social Cognition of Dogs 26 Comparative Social Cognition: From wolf and dog to humans

    E-print Network

    Indiana University

    Comparative Social Cognition of Dogs 26 Comparative Social Cognition: From wolf and dog to humans Enik Kubinyi, Zsófia Virányi, and Ádám Miklósi Eötvös University Dogs' special domestication processes, their natural socialization to humans, and the possibility of tracing evolutionary changes by comparing dogs

  20. Introduction There are many varieties of dog collars available to dog

    E-print Network

    1 Introduction There are many varieties of dog collars available to dog owners today. The primary purpose of a collar is to provide an effective way for the owner to control his/her dog. In addition collars are appropriate for wear at all times, while others are specifically for walking the dog

  1. Evaluating the effect of intraoperative peritoneal lavage on bacterial culture in dogs with suspected septic peritonitis

    PubMed Central

    Swayne, Seanna L.; Brisson, Brigitte; Weese, J. Scott; Sears, William

    2012-01-01

    This pilot study describes the effect of intraoperative peritoneal lavage (IOPL) on bacterial counts and outcome in clinical cases of septic peritonitis. Intraoperative samples were cultured before and after IOPL. Thirty-three dogs with presumed septic peritonitis on the basis of cytology were managed surgically during the study period. Positive pre-lavage bacterial cultures were found in 14 cases, 13 of which were a result of intestinal leakage. The post-lavage cultures showed fewer isolates in 9 cases and in 1 case became negative. The number of dogs with a decrease in the concentration of bacteria cultured from pre-lavage to post-lavage samples was not statistically significant. There was no significant effect of the change in pre- to post-lavage culture, single versus multiple types of bacteria, selection of an appropriate empiric antimicrobial on survival or the need for subsequent surgery. PMID:23450861

  2. Scavenging by mammalian carnivores on prairie dog colonies: implications for the spread of plague.

    PubMed

    Boone, Amanda; Kraft, John P; Stapp, Paul

    2009-04-01

    Plague causes mass mortality of prairie dogs (Cynomys ludovicianus) in shortgrass steppe. Although the pathogen, the bacterium Yersinia pestis, is spread within colonies by flea bites or contact between infected hosts, it is unclear how Y. pestis is transported over long distances between isolated colonies. One possibility is that wideranging, plague-resistant mammalian carnivores pick up fleas when scavenging prairie dog carcasses. Using guinea pigs as surrogates for prairie dogs, we compared how quickly scavengers discovered carcasses on active prairie dog colonies, on colonies recently extirpated by plague, and in grasslands without prairie dogs. In June-July 2007, we monitored the fates of 20 guinea pig carcasses for 4 consecutive days on each site type. Ten carcasses were placed in wire exclosures that restricted access only to arthropods and small rodents; the other 10 were exposed to all scavengers. Scavengers were identified by tracks, evidence of consumption, and/or remote cameras. Carnivores discovered carcasses more quickly on active and plague colonies (mean +/- 95% confidence interval [CI]: 1.6 +/- 0.7, 1.4 +/- 1.4 days, respectively) than on grasslands (3.1 +/- 0.7 days). By the end of the trials, all (100%) exposed carcasses were removed from active colonies, whereas 60% were removed from plague colonies and 30% were removed from grasslands. Rates of carcass discovery and removal on active colonies were significantly greater than in grasslands, which mirrored differences in carnivore activity recorded during earlier scat surveys. A small fraction (30%-40%) of carcasses in exclosures were eaten by rodents, but only on active and plague colonies, suggesting that small rodents, presumably grasshopper mice (Onychomys leucogaster), may also consume carcasses and pick up fleas if carcasses are not removed by carnivores first. These results, combined with observations that fleas remain alive on prairie dogs at least 1 day following their death, suggest that carnivores may encounter infectious fleas while scavenging, and they could transport them over long distances. PMID:18945188

  3. "I'm Just a'-Walking the Dog" correlates of regular dog walking.

    PubMed

    Christian nee Cutt, Hayley; Giles-Corti, Billie; Knuiman, Matthew

    2010-01-01

    Intrapersonal and environmental factors associated with dog walking (N = 483) were examined. A greater proportion of regular (80%) than irregular (59%) dog walkers met the recommended 150 minutes of physical activity per week. Owners who perceived greater social support and motivation from their dogs to walk, and who had access to a dog-supportive park within their neighborhood, were more likely to regularly walk with their dogs, even after adjustment for other well-known correlates of physical activity. The higher level of physical activity of regular dog walkers can be attributed to the additional walking these owners perform with their dogs. PMID:20010004

  4. Plasma Creatinine Clearance in the Dog

    ERIC Educational Resources Information Center

    Frazier, Loy W.

    1977-01-01

    Lists materials and methods for an experiment that demonstrates the concept of glomerular filtration rate (GFR) using anesthesized dogs. In the dog, GFR is equivalent to the renal plasma clearance of exogenous creatinine. (CS)

  5. 49 CFR 236.718 - Chart, dog.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ...Transportation 4 2013-10-01 2013-10-01 false Chart, dog. 236.718 Section 236.718 Transportation Other...DEVICES, AND APPLIANCES Definitions § 236.718 Chart, dog. A diagrammatic representation of the mechanical locking...

  6. 49 CFR 236.718 - Chart, dog.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ...Transportation 4 2014-10-01 2014-10-01 false Chart, dog. 236.718 Section 236.718 Transportation Other...DEVICES, AND APPLIANCES Definitions § 236.718 Chart, dog. A diagrammatic representation of the mechanical locking...

  7. 49 CFR 236.718 - Chart, dog.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ...Transportation 4 2012-10-01 2012-10-01 false Chart, dog. 236.718 Section 236.718 Transportation Other...DEVICES, AND APPLIANCES Definitions § 236.718 Chart, dog. A diagrammatic representation of the mechanical locking...

  8. Military Dog Training for Law Enforcement

    ERIC Educational Resources Information Center

    Atwell, Lou E.

    1977-01-01

    Describes five courses involved in the intensive training that dogs and their handlers go through in the Military Dog Studies Branch at Lackland Air Force Base (San Antonio, Texas) in preparation for duties in law enforcement. (HD)

  9. Filaroides hirthi infection in two related dogs.

    PubMed

    Pinckney, R D; Studer, A D; Genta, R M

    1988-11-15

    Filaroides hirthi infection was diagnosed in 2 related Yorkshire Terriers. Dog 1 had a chronic nonproductive cough, but results of fecal flotation examination were negative. Dog 2 was a 1-year-old female progeny of dog 1. Both dogs came from the same kennel and were raised together for 8 weeks. Dog 2 had generalized demodicosis accompanied by secondary bacterial infection and had been treated with corticosteroids. Dog 2 also was given 68 micrograms of ivermectin, PO, and then 50 mg of fenbendazole/kg, PO, q 24 h for 14 days. After the 14-day treatment, results of 3 fecal examinations were negative for Filaroides sp and other parasites, and the dog improved without complications. Fecal examination of the other dogs in the kennel were negative for F hirthi. PMID:3204055

  10. Adoptive Immunotherapy against Allogeneic Kidney Grafts in Dogs with Stable Hematopoietic Trichimerism

    PubMed Central

    Graves, Scott S.; Hogan, William J.; Kuhr, Christian; Diaconescu, Razvan; Harkey, Michael; Sale, George E.; Stone, Brad; Georges, George E.; Storb, Rainer

    2008-01-01

    Dogs given nonmyeloablative conditioning and marrow grafts from two dog leukocyte antigen- (DLA) identical littermate donors developed stable trichimerism and stably accepted a subsequent kidney graft from one of the marrow donors without the need for immunosuppression. Here, we used trichimeras to evaluate strategies of adoptive immunotherapy to solid tumors, using the kidney as a tumor surrogate. Three DLA-identical trichimeric recipients were established by simultaneously infusing marrow from two DLA-identical donor dogs into a DLA-identical recipient conditioned with 2 Gy total body irradiation and given a short course of postgrafting immunosuppression. After confirming stable hematopoietic engraftment, a kidney was transplanted from one of the two marrow donors into each respective trichimeric recipient. Peripheral blood lymphocytes (PBL) from each kidney donor were then used to sensitize the alternate marrow donor. Donor lymphocyte infusions (DLI) from the sensitized dogs were given to the trichimeric recipients, whereupon chimerism, graft-versus-host disease (GvHD), and kidney rejection were monitored. After DLI, we observed both prompt rejection of the transplanted marrow-donor kidney and disappearance of corresponding hematopoietic chimerism. Presumably, owing to shared minor histocompatibility antigens, host chimerism also disappeared and GvHD in skin, gut, and liver developed. The native kidneys, while showing lymphocytic infiltration, remained functionally normal. The current study demonstrated that under certain experimental conditions, the kidney, an organ ordinarily not involved in graft-versus-host reactions, can be targeted by sensitized donor lymphocytes. PMID:18940673

  11. Assessment of coyote-wolf-dog admixture using ancestry-informative diagnostic SNPs

    PubMed Central

    Monzón, J.; Kays, R.; Dykhuizen, D. E.

    2014-01-01

    The evolutionary importance of hybridization as a source of new adaptive genetic variation is rapidly gaining recognition. Hybridization between coyotes and wolves may have introduced adaptive alleles into the coyote gene pool that facilitated an expansion in their geographic range and dietary niche. Furthermore, hybridization between coyotes and domestic dogs may facilitate adaptation to human-dominated environments. We genotyped 63 ancestry-informative single nucleotide polymorphisms in 427 canids in order to examine the prevalence, spatial distribution, and ecology of admixture in eastern coyotes. Using multivariate methods and Bayesian clustering analyses, we estimated the relative contributions of western coyotes, western and eastern wolves, and domestic dogs to the admixed ancestry of Ohio and eastern coyotes. We found that eastern coyotes form an extensive hybrid swarm, with all our samples having varying levels of admixture. Ohio coyotes, previously thought to be free of admixture, are also highly admixed with wolves and dogs. Coyotes in areas of high deer density are genetically more wolf-like, suggesting that natural selection for wolf-like traits may result in local adaptation at a fine geographic scale. Our results, in light of other previously published studies of admixture in Canis, reveal a pattern of sex-biased hybridization, presumably generated by male wolves and dogs mating with female coyotes. This study is the most comprehensive genetic survey of admixture in eastern coyotes and demonstrates that the frequency and scope of hybridization can be quantified with relatively few ancestry-informative markers. PMID:24148003

  12. Micturition studies in dogs: simultaneous cystometry flowmetry 

    E-print Network

    Moreau, Philippe Marc

    1982-01-01

    variables were tabulated. No significant differences within individual dogs were seen when vari- ables were analyzed, independent of sex, route of sedative administra- tion or the fact of having had a previous bladder instrumentation- micturition study... weight). Both studies were successfully performed in 5 of these dogs, but in one dog (number 8) technical difficulties prevented completion of the second study. Technical Equipment A device for measuring urine flow in dogs of both sexes...

  13. Handler beliefs affect scent detection dog outcomes

    Microsoft Academic Search

    Lisa LitJulie; Julie B. Schweitzer; Anita M. Oberbauer

    2011-01-01

    Our aim was to evaluate how human beliefs affect working dog outcomes in an applied environment. We asked whether beliefs\\u000a of scent detection dog handlers affect team performance and evaluated relative importance of human versus dog influences on\\u000a handlers’ beliefs. Eighteen drug and\\/or explosive detection dog\\/handler teams each completed two sets of four brief search\\u000a scenarios (conditions). Handlers were falsely

  14. Stray Dogs: Danijel Zezelj

    NSDL National Science Digital Library

    The website of the Isabella Stewart Gardner Museum in Boston has a digitized version of its contemporary exhibition, from several years ago, that featured the drawings of graphic novelist Danijel Zezelj. The digital exhibition provides a written excerpt of an informative "Interview" with the artist by the curator of the exhibit, and visitors can find the interview under the "Artist Biography" link. To view the exhibition, visitors should click on the "Enter the Exhibition" link, which contains the drawings from the graphic novel "Stray Dogs", but without the accompanying text found in the novel. Each page is an artwork in itself, and contains several seemingly separate drawings per page. The beautiful drawings sometimes resemble paintings or lithographs, with their large swaths of ink. The "Exhibition Details" link is an interesting peek inside the business of lending out a museum exhibit, and visitors will find the criteria for borrowing the work including: the space requirements of the exhibition, the required color of the walls (Autumn Purple by Benjamin Moore), the cost to borrow it from the museum, the cost of multimedia performances related to the exhibit, and the cost of an artist talk.

  15. [Biology of aggression in dogs].

    PubMed

    Feddersen-Petersen, D U

    2001-03-01

    The science of ethology is concerned with the way external stimuli and internal events cause animals to fight in a particular way. The classification of dog breeds with respect to their relative danger to humans makes no sense, as both, the complex antecedent conditions in which aggressive behaviour occurs, and its ramifying consequences in the individual dog's ecological and social environment, are not considered. From a biological point of view, environmental and learning effects are always superimposed upon genetic influences. Based on the recent developments in the study of ethology, aggression of wolves (Canis lupus L.) and domesticated dogs (Canis lupus f. familiaris) was put into context with respect to other aspects of the lifestyle of wild and domestic canids. Aggressive behaviour does not occur in a biological vacuum. This is also true for domestic dogs and their relationship to human partners. Individual dogs can become highly aggressive and dangerous. Their development and social situation will be presented and discussed in case studies. Finally, there is the question about defining "normal aggression" versus symptoms for maladaptive aggression resp. danger to humans as conspecifics. It is possible to protect the safety of the public and at the the same time practise animal care. Effective animal control legislation must focus on responsible ownership and socialisation of pups f.e. Problems are not unique to some breeds. PMID:11314475

  16. Echinococcosis in Dogs in the Czech Republic

    Microsoft Academic Search

    V. SVOBODOVÁ; B. LENSKÁ

    2002-01-01

    Svobodová V., B. Lenská: Echinococcosis in Dogs in the Czech Republic. Acta Vet. Brno 2002, 71: 347-350. In central Europe, foxes are principal definitive hosts of Echinococcus multilocularis. However, dogs may become definitive hosts too, and due to close contact with humans they may be the source of infection. We examined samples of dog faeces from the areas with high

  17. 50 CFR 216.82 - Dogs prohibited.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ...2012-10-01 2012-10-01 false Dogs prohibited. 216.82 Section 216...Pribilof Islands Administration § 216.82 Dogs prohibited. In order to prevent molestation of fur seal herds, the landing of any dogs at Pribilof Islands is prohibited....

  18. 49 CFR 236.743 - Dog, swing.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ...Transportation 4 2012-10-01 2012-10-01 false Dog, swing. 236.743 Section 236.743 Transportation...DEVICES, AND APPLIANCES Definitions § 236.743 Dog, swing. A locking dog mounted in such a manner that it is free to...

  19. 49 CFR 236.743 - Dog, swing.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ...Transportation 4 2014-10-01 2014-10-01 false Dog, swing. 236.743 Section 236.743 Transportation...DEVICES, AND APPLIANCES Definitions § 236.743 Dog, swing. A locking dog mounted in such a manner that it is free to...

  20. 49 CFR 236.743 - Dog, swing.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ...Transportation 4 2013-10-01 2013-10-01 false Dog, swing. 236.743 Section 236.743 Transportation...DEVICES, AND APPLIANCES Definitions § 236.743 Dog, swing. A locking dog mounted in such a manner that it is free to...

  1. 50 CFR 216.82 - Dogs prohibited.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ...2014-10-01 2014-10-01 false Dogs prohibited. 216.82 Section 216...Pribilof Islands Administration § 216.82 Dogs prohibited. In order to prevent molestation of fur seal herds, the landing of any dogs at Pribilof Islands is prohibited....

  2. 50 CFR 216.82 - Dogs prohibited.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ...2013-10-01 2013-10-01 false Dogs prohibited. 216.82 Section 216...Pribilof Islands Administration § 216.82 Dogs prohibited. In order to prevent molestation of fur seal herds, the landing of any dogs at Pribilof Islands is prohibited....

  3. Cephalic index and perceived dog trainability

    Microsoft Academic Search

    William S. Helton

    2009-01-01

    People rank breeds of dogs for trainability despite a lack of evidence of breed differences in underlying behaviour. Instead of using behavioural information, people may use dog morphology to determine the trainability of breeds. Dogs are categorized as dolichocephalic, mesocephalic, or brachycephalic based on cephalic index, a ratio between skull width and length. Dolichocephalic breeds are anatomically more specialized for

  4. Dipylidium (Dog and Cat Flea Tapeworm) FAQs

    MedlinePLUS

    ... the most common kind of tapeworm dogs and cats get? The most common tapeworm of dogs and cats in the United States is called Dipylidium caninum . ... infected with a tapeworm larvae. A dog or cat may swallow a flea while self-grooming. Once ...

  5. A study of dogs with kennel cough

    Microsoft Academic Search

    IA McCandlish; H Thompson; HJ Cornwell; NG Wright

    1978-01-01

    A detailed study of a population of dogs with kennel cough was undertaken. Twenty-seven (77 per cent) of a total of 35 dogs had pathological evidence of respiratory disease in the form of tracheobronchitis with, in some animals, exudative pneumonia. A variety of viral and bacterial agents were isolated from the respiratory tract of diseased dogs but Bordetella bronchiseptica and

  6. Immunoperoxidase study of adenovirus pneumonia in dogs

    Microsoft Academic Search

    R. Ducatellet; D. Palmer; P. Ossene; J. Hoorens

    1985-01-01

    The pathology of adenovirus pneumonia in 16 dogs is described. Clinically, these dogs had been severely ill, with severe dyspnoea and listlessness, but only faint coughing.Histopathological lesions could be associated directly with the presence of adenovirus antigens in the lungs of these dogs by using an unlabelled immunoperoxidase technique on paraffin tissue sections. The lesions were focal and located in

  7. Black-tailed prairie dog, Cynomys Zudovicianus

    Microsoft Academic Search

    John P. Farrar; Karin L. Coleman; David S. Lynch

    The policy of relocating the black-tailed prairie dog, Cynomys ludovicianus, is becoming more popular than outright extermination. However, the effects of the relocation process on the behavior of these animals is not known. We hypothesized that relocated prairie dogs would not show behavioral differences relative to non- relocated prairie dogs. We recorded response distances to a human intruder in three

  8. Prevalence of Giardia and Cryptosporidium species in dog park attending dogs compared to non-dog park attending dogs in one region of Colorado.

    PubMed

    Wang, Andrea; Ruch-Gallie, Rebecca; Scorza, Valeria; Lin, Philip; Lappin, Michael R

    2012-03-23

    Dog parks are very popular in urban areas, but there are no current studies attempting to correlate visits to dog parks and risk of colonization by enteric parasites. The purpose of this study was to determine whether dog park visitation is associated with an increased prevalence of enteric parasites or an increase in prevalence of gastrointestinal signs in dogs in northern Colorado. Feces from dogs owned by veterinary students or Veterinary Teaching Hospital staff members were submitted with a completed survey form detailing dog park attendance rates, fecal character scores, and other clinical information. Feces were examined microscopically for parasites after sugar centrifugation, for Giardia spp. cysts and Cryptosporidium spp. oocysts by a commercially available immunofluorescence assay (FA) and the FA positive samples were genotyped after PCR amplification. The Giardia assemblages were determined using the glutamate dehydrogenase (GDH) ?-giardin and triose phosphate isomerase (TPI) genes and the Cryptosporidium species were determined using the heat shock protein-70 gene. A total of 129 fecal samples were assayed; 66 were from dog park attending dogs and 63 were from non-dog park-attending dogs. The overall parasite prevalence rate was 7.0% (9 of 129 samples). Dog park attending dogs were more likely to be positive for Giardia or Cryptosporidium than non-dog park-attending dogs (p=0.0279), but there was no association of gastrointestinal signs with dog park attendance or with fecal flotation or FA results. The five Giardia isolates were assemblage C and/or D and the one Cryptosporidium isolate was Ctenocephalides canis. PMID:21890275

  9. Dog ecology and demography in Antananarivo, 2007

    PubMed Central

    Ratsitorahina, Maherisoa; Rasambainarivo, Jhon H; Raharimanana, Soloherilala; Rakotonandrasana, Hary; Andriamiarisoa, Marie-Perle; Rakalomanana, Fidilalao A; Richard, Vincent

    2009-01-01

    Background Rabies is a widespread disease in African domestic dogs and a serious public health problem in developing countries. Canine rabies became established in Africa during the 20th century, coinciding with ecologic changes that favored its emergence in canids. This paper reports the results of a cross-sectional study of dog ecology in the Antananarivo urban community in Madagascar. A questionnaire survey of 1541 households was conducted in Antananarivo from October 2007 to January 2008. The study addressed both owned and unowned dogs. Various aspects of dog ecology were determined, including size of dog population, relationship between dogs and humans, rabies vaccination. Results Dog ownership was common, with 79.6 to 94.1% (mean 88.9%) of households in the six arrondissements owning dogs. The mean owned dog to person ratio was 1 dog per 4.5 persons and differed between arrondissements (administrative districts), with ratios of 1:6.0 in the first arrondissement, 1:3.2 persons in the 2nd, 1:4.8 in the 3rd, 1:5.2 in the 4th, 1:5.6 in the 5th and 1:4.4 in the 6th arrondissement. Overall, there were more male dogs (61.3%) and the male/female sex ratio was estimated to be 1.52; however, mature females were more likely than males to be unowned (OR: 1.93, CI 95%; 1.39dogs were never restricted and roamed freely to forage for food and mix with other dogs. Only a small proportion of dogs (11.7%) were fed with commercial dog food. Only 7.2% of owned dogs had certificates confirming vaccination against rabies. The proportion of vaccinated dogs varied widely between arrondissements (3.3% to 17.5%). Conclusion Antananarivo has a higher density of dogs than many other urban areas in Africa. The dog population is unrestricted and inadequately vaccinated against rabies. This analysis of the dog population will enable targeted planning of rabies control efforts. PMID:19486516

  10. Handler beliefs affect scent detection dog outcomes.

    PubMed

    Lit, Lisa; Schweitzer, Julie B; Oberbauer, Anita M

    2011-05-01

    Our aim was to evaluate how human beliefs affect working dog outcomes in an applied environment. We asked whether beliefs of scent detection dog handlers affect team performance and evaluated relative importance of human versus dog influences on handlers' beliefs. Eighteen drug and/or explosive detection dog/handler teams each completed two sets of four brief search scenarios (conditions). Handlers were falsely told that two conditions contained a paper marking scent location (human influence). Two conditions contained decoy scents (food/toy) to encourage dog interest in a false location (dog influence). Conditions were (1) control; (2) paper marker; (3) decoy scent; and (4) paper marker at decoy scent. No conditions contained drug or explosive scent; any alerting response was incorrect. A repeated measures analysis of variance was used with search condition as the independent variable and number of alerts as the dependent variable. Additional nonparametric tests compared human and dog influence. There were 225 incorrect responses, with no differences in mean responses across conditions. Response patterns differed by condition. There were more correct (no alert responses) searches in conditions without markers. Within marked conditions, handlers reported that dogs alerted more at marked locations than other locations. Handlers' beliefs that scent was present potentiated handler identification of detection dog alerts. Human more than dog influences affected alert locations. This confirms that handler beliefs affect outcomes of scent detection dog deployments. PMID:21225441

  11. Examining how presumed media influence affects social norms and adolescents' attitudes and drinking behavior intentions in rural Thailand.

    PubMed

    Ho, Shirley S; Poorisat, Thanomwong; Neo, Rachel L; Detenber, Benjamin H

    2014-01-01

    This study uses the influence of presumed media influence model as the theoretical framework to examine how perceived social norms (i.e., descriptive, subjective, and injunctive norms) will mediate the influence of pro- and antidrinking media messages on adolescents' intention to consume alcohol in rural Thailand. Data collected from 1,028 high school students indicate that different mechanisms underlie drinking intentions between nondrinkers and those who have consumed alcohol or currently drink. Among nondrinkers, perceived peer attention to prodrinking messages indirectly influenced adolescents' prodrinking attitudes and intentions to consume alcohol through all three types of perceived social norms. Among drinkers, perceived peer attention to pro- and antidrinking messages indirectly influenced adolescents' prodrinking attitudes and intentions to drink alcohol through perceived subjective norm. The findings provide support for the extended influence of presumed media influence model and have practical implications for how antidrinking campaigns targeted at teenagers in Thailand might be designed. PMID:24354888

  12. On the presumed inductive behaviour of electrolyte solutes in low frequency conductance. Part I: Deficiency of the employed measurement technique

    NASA Astrophysics Data System (ADS)

    Bisschop, Frank De

    2009-08-01

    A measurement technique is examined that served to investigate the low frequency conductance of electrolyte solutes. The set-up, analyzed on the basis of its equivalent circuit, shows major deficiencies, which actually caused the observed frequency dispersion and the presumed inductive behaviour. The problem, basically, is due to the use of non-contacting electrodes for signal in/out coupling, in combination with a capillary flow cell as sample holder.

  13. Cricopharyngeal achalasia in a dog.

    PubMed

    Pfeifer, Renate M

    2003-12-01

    A 4-month-old, female terrier-poodle cross was presented with a chronic history of dysphagia. Fluoroscopic swallowing studies localized the problem to the upper esophageal sphincter. A diagnosis of cricopharyngeal achalasia was made. After cricopharyngeal and thyropharyngeal myectomy, the dog was able to eat soft food without difficulty. PMID:14703088

  14. Lessons from a Dog Musher

    Microsoft Academic Search

    Jeannie Whitman

    2002-01-01

    Through the analogy of an Alaskan Iditarod dog-mushing team, this article will identify how the critical elements of motivation, understanding, synergy, and hunger underscore the vital role motivation plays in the delivery of quality care and positive outcomes. Whether it is in the thorough completion of a care assessment at intake or discharge or the education of a patient, all

  15. Irrational fears in the dog

    Microsoft Academic Search

    Ronald Melzack

    1952-01-01

    Using as criteria of fear reactions a turning away, crouching, or running, 26 home-reared dogs were tested with various stationary objects and objects with moving parts, including toy lizards, skulls, soap bubbles, etc. Avoidance responses were most frequent to objects with moving parts. Learning was found to play an important role.

  16. Beware of dogs licking ears.

    PubMed

    Godey, B; Morandi, X; Bourdiničre, J; Heurtin, C

    1999-10-01

    A patient with right-sided chronic purulent otorrhoea developed meningitis due to Pasteurella multocida transmitted by a dog that frequently licked his ear. We suggest that patients with a perforated tympanic membrane should avoid being licked on their ears by animals. PMID:10520644

  17. Hepatosplenic lymphoma in a dog

    Microsoft Academic Search

    Michael M Fry; W. Vernau; C Bromel; P A Pesavento; P. F. Moore

    2003-01-01

    We describe a case of a dog with hepatosplenic lymphoma, a disease characterized by infiltration of the liver, spleen, and bone marrow with gammadelta T cells, absence of peripheral lymphadenopathy, and an aggressive clinical course. Physical examination findings, hematologic and biochemical abnormalities, and clinical course of the disease in this patient were similar to those in humans. Immunophenotyping of liver

  18. 77 FR 54368 - Service Dogs

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-05

    ...dog may be the optimal means for that veteran to regain a standing position and stabilize after a fall. In such a case, the...VA would expect a veteran to protect and utilize his or her wheelchair in order to keep it in good working condition, or keep...

  19. Predictive Factors of Successful Microdissection Testicular Sperm Extraction in Patients with Presumed Sertoli Cell-Only Syndrome

    PubMed Central

    Modarresi, Tahereh; Hosseinifar, Hani; Daliri Hampa, Ali; Chehrazi, Mohammad; Hosseini, Jalil; Farrahi, Faramarz; Dadkhah, Farid; Sabbaghian, Marjan; Sadighi Gilani, Mohammad Ali

    2015-01-01

    Background To evaluate predictive factors of successful microdissection-testicular sperm extraction (MD-TESE) in patients with presumed Sertoli cell-only syndrome (SCOS). Materials and Methods In this retrospective analysis, 874 men with non-obstructive azoospermia (NOA), among whom 148 individuals with diagnosis of SCOS in prior biopsy, underwent MD-TESE at Department of Andrology, Royan Institute, Tehran, Iran. The predictive values of follicle stimulating hormone (FSH), luteinizing hormone (LH), and testosterone (T) levels, testicular volume, as well as male age for retrieving testicular sperm by MD-TESE were analyzed by multiple logistic regression analysis. Results Testicular sperm were successfully retrieved in 23.6% men with presumed SCOS. Using receiver operating characteristic (ROC) curve analysis, it was shown that sperm retrieval rate in the group of men with FSH values >15.25% was 28.9%. This was higher than the group of men with FSH ?15.25 (11.8%). Conclusion Sperm retrieval rate (SRR) was 23.6% in men with presumed SCOS and FSH level can be a fair predictor for SPR at MD-TESE. MD-TESE appears to be recommendable in such cases (SCOS with high FSH concentration) with reasonable results. PMID:25918598

  20. )_ ^ ^^> ill / 5 4-H Dog Care and Training

    E-print Network

    New Hampshire, University of

    an older dog. For those boys and girls with a strong interest in dogs, career opportu- nities in the field)_ ^ ^^> ill · / 5 4-H Dog Care and Training Leader Guide 4-H 120L Revised July 1985 Oregon State This publication is for 4-H dog club leaders to use in working more effectively with 4-H members in 4-H dog

  1. PRAIRIE DOGS AS ECOSYSTEM REGULATORS ON THE NORTHERN HIGH PLAINS

    Microsoft Academic Search

    Daniel W. Uresk

    The increase in prairie dog populations on the northern High Plains has emphasized the need for additional information on cattle-prairie dog forage relationships. To obtain information on cattle-prairie dog forage relationships, 4 treatments were evaluated over 4 growing seasons. These treatments were: 1) no grazing (prairie dogs eliminated and cattle excluded), 2) grazing by prairie dogs, 3) grazing by cattle

  2. 9 CFR 93.600 - Importation of dogs.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ...2014-01-01 2014-01-01 false Importation of dogs. 93.600 Section 93.600 Animals and Animal...FOR MEANS OF CONVEYANCE AND SHIPPING CONTAINERS Dogs § 93.600 Importation of dogs. (a) All dogs. Dogs from any...

  3. 9 CFR 93.600 - Importation of dogs.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ...2013-01-01 2013-01-01 false Importation of dogs. 93.600 Section 93.600 Animals and Animal...FOR MEANS OF CONVEYANCE AND SHIPPING CONTAINERS Dogs § 93.600 Importation of dogs. (a) All dogs. Dogs from any...

  4. Aggressive conflicts amongst dogs and factors affecting them

    Microsoft Academic Search

    A. Roll; J. Unshelm

    1997-01-01

    Over one year, 206 dog owners were questioned in a veterinary clinic. The survey included two groups: 151 owners who visited the clinic because of an injury to their dog caused by another dog and 55 people who owned dogs that caused injuries to others. The questioning served to compare aggressors and victims of dog fights. The form contained 43

  5. [Lens luxation in dogs: a retrospective study of 134 dogs (2000-2011)].

    PubMed

    Betschart; Hässig; Spiess

    2014-03-01

    This retrospective study evaluated cases of lens luxation in dogs that were documented at the University of Zurich Veterinary Teaching Hospital between 2000 and 2011. A total 134 dogs were included in the study. This population of dogs with lens luxation represents 0.41 % of all dogs presented to the Zurich Veterinary Teaching Hospital (32'523) and 3.02 % of all dogs presented to the ophthalmology service during the same time period. The 134 dogs represented over 40 different breeds, including mixed breeds. 63 of the dogs were male, 71 were female. The 134 dogs were divided in primary lens luxation (86 of the 134 dogs, 64 %) and secondary lens luxation (48 dogs, 36 %). The most frequent causes for secondary lens luxation were glaucoma (58 %), cataract (19 %) and trauma (17 %). This study shows the predisposition for primary lens luxations in terrier breeds, Chinese Crested dogs, Pinscher and Spitz. In contrast, Siberian Huskies, Basset Hounds, Bearded Collies, Cairn Terriers, mixed breed dogs, Bolonka Zwetna, Boston Terriers, Borzoi, Doberman, Eurasian, Leonberg, Luzerner Niederlaufhund and Weimaraner suffered significantly more often from secondary lens luxation. There was no sex predilection for primary or secondary lens luxation. Dogs with primary lens luxation were on average 7.39 ± 3.02 years old, which is significantly younger than the dogs with secondary lens luxation (9.12 ± 3.38 years). Dogs with primary lens luxation showed a significantly higher rate of a bilateral development than those with secondary lens luxation (85.5 % of the dogs with primary lens luxation and only 14.5 % of the dogs with secondary lens luxation showed it in both their eyes). PMID:24568806

  6. Dog keeping in Taiwan: its contribution to the problem of free-roaming dogs.

    PubMed

    Hsu, Yuying; Severinghaus, Lucia Liu; Serpell, James A

    2003-01-01

    This study conducted a quantitative ethnographic analysis of the influence of demographic factors and early experience (childhood exposure to dogs) on Taiwanese dog-keeping practices and behavior. A telephone survey of a randomly selected sample of 2001 Taiwan residents determined their dog ownership histories, current patterns of dog ownership and disposal, and other dog-related activities. The results suggest that low rates of neutering, easy availability of low- or no-cost puppies, a tendency to allow owned dogs free access to the outdoors, unrealistic expectations of dog ownership, canine behavioral problems, and religious and cultural taboos against euthanasia and shelter relinquishment have contributed to the recent increase in the numbers of free-roaming dogs in Taiwan. Logistic regression analyses determined that a relatively small number of demographic and experiential variables predicted dog ownership and disposal patterns. The most important of these was childhood experience of living with household dogs. In light of these findings, future efforts to reduce the stray dog problem should focus on enforcing registration fees, particularly for unsterilized animals; low-cost neutering schemes; and educational programs designed to promote neutering, improve knowledge of canine behavior and behavior problems, and develop more realistic expectations and attitudes toward dog ownership. Marked Taiwanese resistance to canine euthanasia and shelter relinquishment suggests a need for alternative methods of managing the existing free-roaming dog population. PMID:12795855

  7. Pharyngeal mucoceles in dogs: 14 cases.

    PubMed

    Benjamino, Kevin P; Birchard, Stephen J; Niles, Jacqui D; Penrod, Kimberly D

    2012-01-01

    This report describes the clinical features of a series of dogs with pharyngeal salivary mucoceles. A retrospective study of 14 dogs with pharyngeal mucocele was performed. Medical records from 1983 to 2003 were reviewed for information regarding signalment, clinical signs, diagnosis, surgical procedures, and short-term and long-term outcome. Miniature and toy poodles were common breeds in the study population, and 79% of the dogs were male. The most common presenting sign was dyspnea (50%). Diagnosis was by fine-needle aspirate, which revealed a mucoid substance in 93% of dogs. Histopathology of the excised salivary glands revealed lymphoplasmacytic inflammation in all dogs that had histopathology performed. Forty-three percent of the dogs had a cervical mucocele on the same side as the pharyngeal mucocele. Surgical therapy was performed in 13 dogs, which consisted of excision of the mandibular and sublingual salivary glands, excision of the mucocele, or marsupulization of the mucocele. Only two dogs had recurrence of the pharyngeal mucocele. In this study, pharyngeal mucoceles occurred in predominantly small dogs that frequently presented with respiratory signs. Surgical treatment was successful in most dogs. PMID:22186721

  8. Chemical sensing thresholds for mine detection dogs

    NASA Astrophysics Data System (ADS)

    Phelan, James M.; Barnett, James L.

    2002-08-01

    Mine detection dogs have been found to be an effective method to locate buried landmines. The capabilities of the canine olfaction method are from a complex combination of training and inherent capacity of the dog for odor detection. The purpose of this effort was to explore the detection thresholds of a limited group of dogs that were trained specifically for landmine detection. Soils were contaminated with TNT and 2,4-DNT to develop chemical vapor standards to present to the dogs. Soils contained ultra trace levels of TNT and DNT, which produce extremely low vapor levels. Three groups of dogs were presented the headspace vapors from the contaminated soils in work environments for each dog group. One positive sample was placed among several that contained clean soils and, the location and vapor source (strength, type) was frequently changed. The detection thresholds for the dogs were determined from measured and extrapolated dilution of soil chemical residues and, estimated soil vapor values using phase partitioning relationships. The results showed significant variances in dog sensing thresholds, where some dogs could sense the lowest levels and others had trouble with even the highest source. The remarkable ultra-trace levels detectable by the dogs are consistent with the ultra-trace chemical residues derived from buried landmines; however, poor performance may go unnoticed without periodic challenge tests at levels consistent with performance requirements.

  9. 4-H Dog Fitting and Show Score Sheet Date _______________________ Class _________________

    E-print Network

    New Hampshire, University of

    4-H Dog Fitting and Show Score Sheet Date _______________________ Class _________________ Breed ______________________ Armband# ____________ Possible Points Points Earned Dog Condition and Appearance ____ Brushed without matting ____ Clean ears ____ Nails trimmed ____ Dog in good condition, not underweight 10 Handler

  10. Clinical and mycological analysis of dog’s oral cavity

    PubMed Central

    Santin, Rosema; Mattei, Antonella Souza; Waller, Stefanie Bressan; Madrid, Isabel Martins; Cleff, Marlete Brum; Xavier, Melissa Orzechowski; de Oliveira Nobre, Márcia; Nascente, Patrícia da Silva; de Mello, Joăo Roberto Braga; Meireles, Mário Carlos Araújo

    2013-01-01

    The oral microbiota of humans and animals is made up of a wide variety of yeasts and bacteria, but microbiota of dogs is not totally described. Although such identification is an important step to establish the etiopathogenesis and adequate therapy for the periodontal disease The aim of this study was to evaluate and correlate oral alterations with the presence of yeasts in oral cavity of female dogs. After clinical evaluation samples from healthy and from dogs with oral diseases were obtained from three different oral sites by swabs, curettes, millimeter periodontal probes and HA membrane tip in cellulose ester. Yeast identification was performed through macroscopic and microscopic colony features and biochemical tests. Dental calculus was the most prevalent occurrence in the oral cavity of 59 females. However, the isolation of yeasts was significantly higher (p < 0.05) in animals suffering from halitosis. Eleven yeast species were identified, namely: Malassezia pachydermatis, Rhodotorula spp., Candida albicans, C. catenulata, C. famata, C. guilliermondii, C. parapsilosis, C. intermedia, Trichosporon asahii, T. mucoides and Cryptococcus albidus. It could be concluded that the yeasts are part of the microbiota from the different sites of the oral cavity of the female canines studied without causing any significant alterations except halitosis. PMID:24159296

  11. Perineal herniorrhaphy: perioperative data from 100 dogs.

    PubMed

    Hosgood, G; Hedlund, C S; Pechman, R D; Dean, P W

    1995-01-01

    One hundred dogs (83 intact males, 15 castrated males, and two intact females) underwent 110 perineal herniorrhaphy procedures. Mixed-breed dogs (n = 32), miniature poodles (n = 14), Boston terriers (n = 11), and Pekingese (n = 9) were represented most frequently. Perineal swelling (n = 48) and a perineal defect on rectal palpation (n = 31) were common clinical signs. Twenty dogs had urinary bladder retroflexion and were significantly more likely to have elevated serum urea nitrogen and creatinine concentrations, hyperkalemia, hyperphosphatemia, and neutrophilic leukocytosis. Only five of 43 dogs evaluated radiographically had prostatomegaly. Of 30 dogs receiving oral barium, all had rectal deviation. The most frequent complications during the hospitalization period were incisional (n = 35), followed by rectal prolapse (n = 9), tenesmus (n = 8), and depression (n = 8). Fifty-six of 70 dogs with follow-up had no complications. PMID:7552667

  12. Reproductive potential of Echinococcus multilocularis in experimentally infected foxes, dogs, raccoon dogs and cats

    Microsoft Academic Search

    C. M. O. Kapel; P. R. Torgerson; R. C. A. Thompson; P. Deplazes

    2006-01-01

    A total of 15 red foxes, 15 raccoon dogs, 15 domestic dogs and 15 domestic cats were each infected with 20,000 protoscolices of Echinococcus multilocularis. At 35, 63, and 90 days post inoculation (dpi), five animals from each group were necropsied and the worm burdens determined. The highest worm burdens in foxes (mean of 16,792) and raccoon dogs (mean of

  13. Dog handlers' and dogs' emotional and cortisol secretion responses associated with animal-assisted therapy sessions

    Microsoft Academic Search

    D. K. Haubenhofer; S. Kirchengast

    2007-01-01

    The study investigated 13 dog handlers and 18 companion dogs (Canis familiaris) working as teams in nonhuman animal-assisted service. The handlers described in questionnaires what emotions they chose to associate with their daily life and therapeutic work. They described their emotional condition before and after therapeutic sessions, giving analogous descriptions for their dogs. Handlers collected saliva samples from themselves and

  14. Incidence and impact of dog attacks on guide dogs in the UK

    Microsoft Academic Search

    A. Brooks; R. Moxon; G. C. W. England

    2010-01-01

    In a retrospective survey, researchers identified 100 incidents of attacks on guide dogs by other dogs. These were reviewed in order to determine the number, severity and impact on the handler and dog, and the characteristics of the aggressors and victims. During the study period there were more than three attacks reported each month, with 61 per cent of the

  15. Chitosan-inducing hemorrhagic pneumonia in dogs

    Microsoft Academic Search

    S. Minami; M. Oh-oka; Y. Okamoto; K. Miyatake; A. Matsuhashi; Y. Shigemasa; Y. Fukumoto

    1996-01-01

    Various amounts of chitosan (10–200 mg\\/kg) were administered subcutaneously to dogs. Anorexia and mortality were observed in dogs given doses above 50 mg\\/ kg, and above 150 mg\\/kg, respectively. In hematologic findings leukocytosis and increasing of serum LDH2 and LDH3 isoenzymes were characteristic. From the findings of autopsy, severe hemorrhagic pneumonia was observed in all dead dogs. Chitosan causes lethal

  16. Dog bites: how big a problem?

    Microsoft Academic Search

    J. J. Sacks; M. Kresnow; B. Houston

    1996-01-01

    OBJECTIVE: To estimate the magnitude of the dog bite problem in the US. METHODS: Data on dog bites were gathered as part of a 1994 national telephone survey of 5,238 randomly dialed households. Data were weighted to provide national estimates. RESULTS: The weighted total number of dog bites was 4,494,083 (estimated incidence = 18\\/1,000 population); of these, 756,701 persons sustained

  17. Dog bites: Bacteriology, management, and prevention

    Microsoft Academic Search

    Fredrick M. Abrahamian

    2000-01-01

    Dog bites are among the most frequent causes of nonfatal injuries in the United States. Most dog bites involve children and\\u000a young adults. Infected wounds are polymicrobial in nature; the most prevalent organisms are Pasteurella, streptococci, staphylococci, and Fusobacterium, Bacteroides, and Porphyromonas species. Musculoskeletal and neurovascular injuries, as well as systemic infections, can be complications of dog-bite wounds.\\u000a Treatment includes

  18. A study of dogs with kennel cough.

    PubMed

    McCandlish, I A; Thompson, H; Cornwell, H J; Wright, N G

    1978-04-01

    A detailed study of a population of dogs with kennel cough was undertaken. Twenty-seven (77 per cent) of a total of 35 dogs had pathological evidence of respiratory disease in the form of tracheobronchitis with, in some animals, exudative pneumonia. A variety of viral and bacterial agents were isolated from the respiratory tract of diseased dogs but Bordetella bronchiseptica and canine parainfluenza virus SV-5 appeared to be the most significant organisms recovered. PMID:207006

  19. Dogs' social referencing towards owners and strangers.

    PubMed

    Merola, Isabella; Prato-Previde, Emanuela; Marshall-Pescini, Sarah

    2012-01-01

    Social referencing is a process whereby an individual uses the emotional information provided by an informant about a novel object/stimulus to guide his/her own future behaviour towards it. In this study adult dogs were tested in a social referencing paradigm involving a potentially scary object with either their owner or a stranger acting as the informant and delivering either a positive or negative emotional message. The aim was to evaluate the influence of the informant's identity on the dogs' referential looking behaviour and behavioural regulation when the message was delivered using only vocal and facial emotional expressions. Results show that most dogs looked referentially at the informant, regardless of his/her identity. Furthermore, when the owner acted as the informant dogs that received a positive emotional message changed their behaviour, looking at him/her more often and spending more time approaching the object and close to it; conversely, dogs that were given a negative message took longer to approach the object and to interact with it. Fewer differences in the dog's behaviour emerged when the informant was the stranger, suggesting that the dog-informant relationship may influence the dog's behavioural regulation. Results are discussed in relation to studies on human-dog communication, attachment, mood modification and joint attention. PMID:23071828

  20. Dogs' Social Referencing towards Owners and Strangers

    PubMed Central

    Merola, Isabella; Prato-Previde, Emanuela; Marshall-Pescini, Sarah

    2012-01-01

    Social referencing is a process whereby an individual uses the emotional information provided by an informant about a novel object/stimulus to guide his/her own future behaviour towards it. In this study adult dogs were tested in a social referencing paradigm involving a potentially scary object with either their owner or a stranger acting as the informant and delivering either a positive or negative emotional message. The aim was to evaluate the influence of the informant's identity on the dogs' referential looking behaviour and behavioural regulation when the message was delivered using only vocal and facial emotional expressions. Results show that most dogs looked referentially at the informant, regardless of his/her identity. Furthermore, when the owner acted as the informant dogs that received a positive emotional message changed their behaviour, looking at him/her more often and spending more time approaching the object and close to it; conversely, dogs that were given a negative message took longer to approach the object and to interact with it. Fewer differences in the dog's behaviour emerged when the informant was the stranger, suggesting that the dog-informant relationship may influence the dog's behavioural regulation. Results are discussed in relation to studies on human-dog communication, attachment, mood modification and joint attention. PMID:23071828

  1. Ototoxicity in dogs and cats

    PubMed Central

    Oishi, Naoki; Talaska, Andra E.; Schacht, Jochen

    2012-01-01

    Synopsis A variety of drugs in veterinary use have side effects that can potentially damage the senses of hearing or balance in animals. A large body of literature exists on the incidence and mechanisms of “ototoxicity” in experimental animals and in humans, but little is documented in domestic dogs and cats. However, the generality of these adverse actions across species allows us to extrapolate and provide the veterinarian with insight into possible complications of chemotherapy. PMID:23122180

  2. Care of Dogs and Attitudes of Dog Owners in Port-au-Prince, the Republic of Haiti

    Microsoft Academic Search

    William J. Fielding; Melanie Gall; Dick Green; Warren S. Eller

    2012-01-01

    This article reports the first known study on dogs in Port-au-Prince. Interviews with 1,290 residents provided information on 1,804 dogs. More than 57.7% of homes kept dogs. Not all the dogs received vaccinations for rabies (41.6%), even though 28.2% of households had had a household member bitten by a dog. Although the “owned” dog population had decreased as a result

  3. Presumption of Herbicide Exposure and Presumption of Disability During Service for Reservists Presumed Exposed to Herbicide. Interim final rule.

    PubMed

    2015-06-19

    The Department of Veterans Affairs (VA) is amending its regulation governing individuals presumed to have been exposed to certain herbicides. Specifically, VA is expanding the regulation to include an additional group consisting of individuals who performed service in the Air Force or Air Force Reserve under circumstances in which they had regular and repeated contact with C-123 aircraft known to have been used to spray an herbicide agent ("Agent Orange'') during the Vietnam era. In addition, the regulation will establish a presumption that members of this group who later develop an Agent Orange presumptive condition were disabled during the relevant period of service, thus establishing that this service constituted "active, naval, military or air service.'' The effect of this action is to presume herbicide exposure for these individuals and to allow individuals who were exposed to herbicides during reserve service to establish veteran status for VA purposes and eligibility for some VA benefits. The need for this action results from a recent decision by the Secretary of Veterans Affairs to acknowledge that individuals who had regular and repeated exposure to C-123 aircraft that the United States Air Force used to spray the herbicides in Vietnam during Operation Ranch Hand were exposed to Agent Orange. PMID:26103644

  4. Presuming the influence of the media: teenagers' constructions of gender identity through sexual/romantic relationships and alcohol consumption.

    PubMed

    Hartley, Jane E K; Wight, Daniel; Hunt, Kate

    2014-06-01

    Using empirical data from group discussions and in-depth interviews with 13 to 15-year olds in Scotland, this study explores how teenagers' alcohol drinking and sexual/romantic relationships were shaped by their quest for appropriate gendered identities. In this, they acknowledged the influence of the media, but primarily in relation to others, not to themselves, thereby supporting Milkie's 'presumed media influence' theory. Media portrayals of romantic/sexual relationships appeared to influence teenagers' constructions of gender-appropriate sexual behaviour more than did media portrayals of drinking behaviour, perhaps because the teenagers had more firsthand experience of observing drinking than of observing sexual relationships. Presumed media influence may be less influential if one has experience of the behaviour portrayed. Drinking and sexual behaviour were highly interrelated: sexual negotiation and activities were reportedly often accompanied by drinking. For teenagers, being drunk or, importantly, pretending to be drunk, may be a useful way to try out what they perceived to be gender-appropriate identities. In sum, teenagers' drinking and sexual/romantic relationships are primary ways in which they do gender and the media's influence on their perceptions of appropriate gendered behaviour is mediated through peer relationships. PMID:24443822

  5. Presuming the influence of the media: teenagers? constructions of gender identity through sexual/romantic relationships and alcohol consumption

    PubMed Central

    Hartley, Jane E K; Wight, Daniel; Hunt, Kate

    2014-01-01

    Using empirical data from group discussions and in-depth interviews with 13 to 15-year olds in Scotland, this study explores how teenagers’ alcohol drinking and sexual/romantic relationships were shaped by their quest for appropriate gendered identities. In this, they acknowledged the influence of the media, but primarily in relation to others, not to themselves, thereby supporting Milkie's ‘presumed media influence’ theory. Media portrayals of romantic/sexual relationships appeared to influence teenagers’ constructions of gender-appropriate sexual behaviour more than did media portrayals of drinking behaviour, perhaps because the teenagers had more firsthand experience of observing drinking than of observing sexual relationships. Presumed media influence may be less influential if one has experience of the behaviour portrayed. Drinking and sexual behaviour were highly interrelated: sexual negotiation and activities were reportedly often accompanied by drinking. For teenagers, being drunk or, importantly, pretending to be drunk, may be a useful way to try out what they perceived to be gender-appropriate identities. In sum, teenagers’ drinking and sexual/romantic relationships are primary ways in which they do gender and the media's influence on their perceptions of appropriate gendered behaviour is mediated through peer relationships. PMID:24443822

  6. Mixed-Breed Dogs Increasing in Popularity

    NSDL National Science Digital Library

    To the average person words such as cockapoo, yorkipoo, and dorgi may seem inappropriate for polite conversation, but in actuality they are the names of mixed-breed dogs. Previously, many of these mixed-breed dogs (formerly referred to as mutts), would have been of little interest. But in recent years more and more people have become entranced with having these animals as household pets. The labradoodle, for example, was originally bred in Australia in the 1970s, and was used as a guide dog for allergy sufferers. These dogs are not at all cheap however, as some of these labradoodles can cost up to $4000. Another interesting development is that the labradoodle may become eligible for American Kennel Club recognition if there are at least 300 of them in at least 20 states with three substantiated generations of labradoodle to labradoodle mixing. Some dog experts are also touting the merits of these new mixes, claiming that the are in fact healthier than purebreds. Other experts in the field remain skeptical, such as Allan Reznik, editor-in-chief of Dog Fancy and Dog World magazines, who opined thusly: "It's indicative of a society that loves labels. Having a dog that is part spaniel and part poodle isn't enough -- it has to be a cockapoo."The first link leads to a news story from CNN.com that documents this latest trend in designer dogs, along with a nice table that deciphers what the names of these mixed-breeds mean exactly. The second link leads to another story about these new hybrid dogs from the National Geographic website, authored by Bijal P. Trivedi. The third link will take visitors to the homepage of the American Kennel Club, where they may read about various purebred dogs, browse a calendar of related events, and learn about the upcoming national dog championship event sponsored by the Club that will take place in Long Beach, California. The fourth link leads to a page devoted to the Schnoodle (a cross between a poodle and a schnauzer) provided by the Dog Breeder Info Center website. The fifth link leads to a site created by Catherine N. Ball (an adjunct professor of linguistics at Georgetown University) that offers a list of the words for the sounds that dogs make in several dozen languages, including Croatian, Esperanto, and Bengali. The final link leads to a fun site that allows visitors to engage in a virtual dog simulation game where they can prepare their animals to compete in the show ring.

  7. A survey of the dog population in rural Bangladesh.

    PubMed

    Hossain, Moazzem; Ahmed, Kamruddin; Marma, Aung Swi Prue; Hossain, Sohrab; Ali, Mohammad Azmat; Shamsuzzaman, Abul Khair Mohammad; Nishizono, Akira

    2013-08-01

    Globally, Bangladesh ranks third in the number of human deaths from rabies. Although dogs are the principal known transmitters of rabies and knowledge of dog populations is essential for effective national control and proper planning, dog control programs are scarce in Bangladesh. Our objective was to count dogs in a rural area to understand the dog population of the country. For this purpose we selected six unions of Raipura upazila in Narsingdi district. Dog counting was done by direct observation following accepted guidelines. We determined the mean density of the dog population in Bangladesh to be 14 dog/km(2) (95% CI 3.7, 24) and the human:dog ratio to be 120 (95% CI 55, 184). Our paper contribute to the literature which shows great variation in the human:dog ratio across regions of the developing world. The human:dog ratio depends on the area's human (as well as dog) population, whereas dog density per unit area indicates the true number of dogs. We propose that extrapolating from the human:dog ratios of other regions not be relied upon for estimating dog populations, unless the ratios can be supplemented by actual counts of dogs within the target area. PMID:23590964

  8. POLLUTION DETECTION DOGS: PROOF OF CONCEPT

    EPA Science Inventory

    Dogs have been used extensively in law enforcement and military applications to detect narcotics and explosives for over thirty years. Dogs are regularly used in arson investigations to detect accelerants since they are much more accurate at discriminating between accelerants an...

  9. Utilization of police dogs: a Turkish perspective

    Microsoft Academic Search

    S. Sebnem Ozcan; Hulki Akin; Hakan Bayram; Musa Bas; Ahmet Yildiz; Atalay Ozdemiroglu

    2009-01-01

    Purpose – The use of canines in the gathering of evidence is a valuable tool for law enforcement to discover crime and criminals. Narcotics, explosives, cadaver detection, search and rescue, or patrol dogs are prevalently used by most police organizations for combatting crime. Police service dogs decrease the time required and increase success in crime detection. The purpose of this

  10. Spontaneous diabetes in dogs and cats

    Microsoft Academic Search

    W. Gepts; D. Toussaint

    1967-01-01

    Summary  A histological study of 30 spontaneously diabetic dogs and 5 spontaneously diabetic cats is presented. — The islets of Langerhans and the B cells were strongly reduced in number in a large majority of the diabetic dogs. The B cells were often degranulated and hydropic. In cases of longer duration, the islets were scarce and B cells could no longer

  11. Dog Bite Prevention: A New Screening Tool

    PubMed Central

    Dixon, Cinnamon A.; Mahabee-Gittens, E. Melinda; Hart, Kimberly W.; Lindsell, Christopher J.

    2011-01-01

    Objectives To determine what children know about preventing dog bites and parental desires for dog bite prevention education. Study design This cross-sectional study sampled 5-15 year olds and their parents/guardians presenting to a pediatric emergency department with non-urgent complaints or dog bites. Pairs completed surveys and knowledge-based simulated scenario tests developed from American Academy of Pediatrics (AAP) and Center for Disease Control and Prevention (CDC) dog bite prevention recommendations. Regression analyses modeled knowledge test scores and probability of passing; a passing score was ?11/14 questions. Results Of 300 parent/child pairs, 43% of children failed the knowledge test. Older children had higher odds of passing the knowledge test than younger children, as did children with white parents versus non-white parents. No associations were found between knowledge scores and other sociodemographic or experiential factors. Over 70% of children had never received dog bite prevention education, although 88% of parents desired it. Conclusion Dog bites are preventable injures disproportionately affecting children. Dog bite prevention knowledge in our sample was poor, particularly among younger children and children with non-white parents. Formal dog bite prevention education is warranted and welcomed by a majority of parents. PMID:21885057

  12. Context specificity of inhibitory control in dogs

    PubMed Central

    MacLean, Evan L.; Hare, Brian A.

    2014-01-01

    Across three experiments, we explored whether a dog's capacity for inhibitory control is stable or variable across decision-making contexts. In the social task, dogs were first exposed to the reputations of a stingy experimenter that never shared food and a generous experimenter who always shared food. In subsequent test trials, dogs were required to avoid approaching the stingy experimenter when this individual offered (but withheld) a higher-value reward than the generous experimenter did. In the A-not-B task, dogs were required to inhibit searching for food in a previously rewarded location after witnessing the food being moved from this location to a novel hiding place. In the cylinder task, dogs were required to resist approaching visible food directly (because it was behind a transparent barrier), in favor of a detour reaching response. Overall, dogs exhibited inhibitory control in all three tasks. However, individual scores were not correlated between tasks, suggesting that context has a large effect on dogs' behavior. This result mirrors studies of humans, which have highlighted intra-individual variation in inhibitory control as a function of the decision-making context. Lastly, we observed a correlation between a subject's age and performance on the cylinder task, corroborating previous observations of age-related decline in dogs' executive function. PMID:23584618

  13. PRAIRIE DOG DENSITY AND CATTLE GRAZING RELATIONSHIPS

    Microsoft Academic Search

    DANIEL W. URESK; JAMES G. MacCRACKEN; ARDELL J. BJUGSTAD

    Blacktail prairie dogs (Cynomys ludovicianus) were more abundant (P < 0.01) in areas of southwestern South Dakota heavily grazed by cattle than in areas where cattle were excluded. Results suggest that periodic exclusions or reduced cattle stocking rates, in combination with control programs, help regulate prairie dog population increase and expansion as indexed by burrow counts.

  14. Checking a Prairie Dog for Fleas

    USGS Multimedia Gallery

    National Park Service veterinarian Kevin Castle checks an anaesthetized prairie dog for fleas in Wind Cave National Park.  Over 30 organizations and agencies are testing a USGS-developed oral vaccine to prevent the spread of plague in prairie dogs. If successful, the sylvat...

  15. 49 CFR 236.742 - Dog, locking.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ...Transportation 4 2012-10-01 2012-10-01 false Dog, locking. 236.742 Section 236.742 Transportation...SYSTEMS, DEVICES, AND APPLIANCES Definitions § 236.742 Dog, locking. A steel block attached to a locking bar or...

  16. Interactions of wolves and dogs in Minnesota

    USGS Publications Warehouse

    Fritts, S.H.; Paul, W.J.

    1989-01-01

    This article reports on the nature and extent of wolf-dog interactions in Minnesota, based on investigations of complaints received by personnel of the federal government dealing with wolf-depredation control. Findings may indicate the wolf-dog interactions that can be expected in other recovery areas.

  17. 49 CFR 236.742 - Dog, locking.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ...Transportation 4 2013-10-01 2013-10-01 false Dog, locking. 236.742 Section 236.742 Transportation...SYSTEMS, DEVICES, AND APPLIANCES Definitions § 236.742 Dog, locking. A steel block attached to a locking bar or...

  18. Genetic Structure of the Purebred Domestic Dog

    Microsoft Academic Search

    Heidi G. Parker; Lisa V. Kim; Nathan B. Sutter; Scott Carlson; Travis D. Lorentzen; Tiffany B. Malek; Gary S. Johnson; Hawkins B. DeFrance; Elaine A. Ostrander; Leonid Kruglyak

    2004-01-01

    We used molecular markers to study genetic relationships in a diverse collection of 85 domestic dog breeds. Differences among breeds accounted for ~30% of genetic variation. Microsatellite genotypes were used to correctly assign 99% of individual dogs to breeds. Phylogenetic analysis separated several breeds with ancient origins from the remaining breeds with modern European origins. We identified four genetic clusters,

  19. The Domestication of Social Cognition in Dogs

    Microsoft Academic Search

    Brian Hare; Michelle Brown; Christina Williamson; Michael Tomasello

    2002-01-01

    Dogs are more skillful than great apes at a number of tasks in which they must read human communicative signals indicating the location of hidden food. In this study, we found that wolves who were raised by humans do not show these same skills, whereas domestic dog puppies only a few weeks old, even those that have had little human

  20. 49 CFR 236.742 - Dog, locking.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ...Transportation 4 2014-10-01 2014-10-01 false Dog, locking. 236.742 Section 236.742 Transportation...SYSTEMS, DEVICES, AND APPLIANCES Definitions § 236.742 Dog, locking. A steel block attached to a locking bar or...

  1. Physiological reactions to fear provocation in dogs

    Microsoft Academic Search

    E Hydbring-Sandberg; L W von Walter; K Höglund; K Svartberg; L Swenson; B Forkman

    2004-01-01

    Fear is a common behavioral problem in dogs. In this paper, we studied the association between behavioral and physiological responses in two potentially fear-eliciting situations. The aim was to establish whether it is possible to separate dogs of the collie breed that are fearful of floors and gunshots from those that are not by studying changes in heart rate and

  2. Going to the 'Dogs' to Test Hypotheses.

    ERIC Educational Resources Information Center

    Kramm, Kenneth R.

    1982-01-01

    Describes an alternative method for using live animals in the classroom. A toy dog, the "Trail Tracker Hound Dog" (manufactured by CPG Products Corporation, Cincinnati, Ohio), is used to encourage development of such skills as observation, hypothesis testing, and collection and analysis of scientific data. (Author/JN)

  3. Motor laterality in 4 breeds of dog

    Microsoft Academic Search

    Paul D. McGreevy; Alex Brueckner; Peter C. Thomson; Nicholas J. Branson

    2010-01-01

    The aim of the current study was designed to explore possible breed differences in a basic behavioral phenotype in dogs. It measured paw use during food-retrieval from a cylindrical, hollow, rubber toy to assess motor laterality (pawedness) in 4 breeds of dogs selected for their morphological differences: 45 greyhounds (males n = 23\\/females n = 22), 47 whippets (15\\/32), 46

  4. Dog star rising: the canine genetic system

    Microsoft Academic Search

    Nathan B. Sutter; Elaine A. Ostrander

    2004-01-01

    Purebred dogs are providing invaluable information about morphology, behaviour and complex diseases, both of themselves and humans, by supplying tractable populations in which to map genes that control those processes. The diversification of dog breeds has led to the development of breeds enriched for particular genetic disorders, the mapping and cloning of which have been facilitated by the availability of

  5. Nasca classification of hemivertebra in five dogs

    PubMed Central

    2005-01-01

    Five dogs, four small mixed breed and a Doberman Pinscher, presented in our clinic with hemivertebra. Complete physical, radiological and neurological examinations were done and the spinal deformities were characterized in accord with the Nasca classification used in human medicine. Two dogs had multiple hemivertebrae (round, oval or wedge-shaped: Type 3) in the thoracic region; one dog had an individual surplus half vertebral body (Type 1) plus a wedge-shaped hemivertebra (Type 2b) in the lumbar region; one dog had multiple hemivertebrae which were fused on one side (Type 4a) in the thoracic region; and one dog had a wedge-shaped hemivertebra (Type 2a) in the cervical region. PMID:21851666

  6. Dog Models of Naturally Occurring Cancer

    PubMed Central

    Rowell, Jennie L.; McCarthy, Donna O.; Alvarez, Carlos E.

    2011-01-01

    Studies using dogs provide an ideal solution to the gap in animal models of natural disease and translational medicine. This is evidenced by approximately 400 inherited disorders being characterized in domesticated dogs, most of which are relevant to humans. There are several hundred isolated populations of dogs (breeds) and each has vastly reduced genetic variation compared to humans; this simplifies disease mapping and pharmacogenomics. Dogs age five to eight-fold faster than humans, share environments with their owners, are usually kept until old age, and receive a high level of health care. Farseeing investigators recognized this potential and, over the last decade, developed the necessary tools and infrastructure to utilize this powerful model of human disease, including the sequencing of the dog genome in 2005. Here we review the nascent convergence of genetic and translational canine models of spontaneous disease, focusing on cancer. PMID:21439907

  7. Functional MRI in Awake Unrestrained Dogs

    PubMed Central

    Berns, Gregory S.; Brooks, Andrew M.; Spivak, Mark

    2012-01-01

    Because of dogs' prolonged evolution with humans, many of the canine cognitive skills are thought to represent a selection of traits that make dogs particularly sensitive to human cues. But how does the dog mind actually work? To develop a methodology to answer this question, we trained two dogs to remain motionless for the duration required to collect quality fMRI images by using positive reinforcement without sedation or physical restraints. The task was designed to determine which brain circuits differentially respond to human hand signals denoting the presence or absence of a food reward. Head motion within trials was less than 1 mm. Consistent with prior reinforcement learning literature, we observed caudate activation in both dogs in response to the hand signal denoting reward versus no-reward. PMID:22606363

  8. Landscape effects on black-tailed prairie dog colonies

    Microsoft Academic Search

    Whitney C. Johnson; Sharon K. Collinge

    2004-01-01

    Black-tailed prairie dogs (Cynomys ludovicianus) increasingly compete for available habitat with human development in the Colorado Front Range. Because the effects of increased urbanization on prairie dog colonies are unknown, we studied how landscape context affects prairie dog density in Boulder County, Colorado, USA. We used burrow density as a proxy for prairie dog density because these variables were correlated

  9. Comparative social ecology of feral dogs and wolves

    Microsoft Academic Search

    L. Boitani; P. Ciucci

    1995-01-01

    In this paper we compare some socio-ecological traits of feral dogs and wolves in order to assess the social ecology of feral dogs in terms of its adaptive value in the natural environment, and to evaluate to what extent the domestication process altered the wolf's socio-ecological patterns. Referring to feral dogs as those dogs living in a wild state with

  10. Dogs as Sentinels for Human Lyme Borreliosis in The Netherlands

    Microsoft Academic Search

    H. A. T. Goossens; A. E. van den Bogaard; M. K. E. Nohlmans

    2001-01-01

    Serum samples from hunters (n 5 440), their hunting dogs (n 5 448), and hunters without dog ownership (n 5 53) were collected in The Netherlands at hunting dog trials and were tested for antibodies against Borrelia burgdorferi by a whole-cell enzyme-linked immunosorbent assay. Additionally, 75 healthy pet dogs were tested. The results of this study indicate that the seroprevalence

  11. Papillary squamous cell carcinoma in three young dogs

    Microsoft Academic Search

    G K Ogilvie; J P Sundberg; M K OBanion; R R Badertscher; L G Wheaton; M E Reichmann

    1988-01-01

    Papillary squamous cell carcinomas were located on the gingiva of 3 young dogs. The tumors locally invaded the soft tissues of each dog, and invaded bone in 2 dogs. Surgical excision was unsuccessful in eliminating 2 of the tumors. Surgery and radiotherapy were effective, and recurrence has not been observed in 39 months in 1 dog, 32 months in a

  12. 36 CFR 520.11 - Dogs and other animals.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ...Property 3 2013-07-01 2012-07-01 true Dogs and other animals. 520.11 Section 520.11...PARK OF THE SMITHSONIAN INSTITUTION § 520.11 Dogs and other animals. Dogs and other animals, except seeing-eye dogs,...

  13. Fluffiness of dog Fluffiness of towel Inferring Analogous Attributes

    E-print Network

    Grauman, Kristen

    Fluffiness of dog Fluffiness of towel = ?? Inferring Analogous Attributes Chao-Yeh Chen and Kristen dogs A striped dog? Yes. + Prediction3 ?? = Inferred attribute21 Learned category-sensitive attributes Dog Equine Spotted BrownStriped + - + - + - + - No training examples ?? Attribute Category No training

  14. 36 CFR 504.10 - Dogs and other animals.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ...Property 3 2014-07-01 2014-07-01 false Dogs and other animals. 504.10 Section 504.10...SMITHSONIAN INSTITUTION BUILDINGS AND GROUNDS § 504.10 Dogs and other animals. Dogs and other animals, except seeing-eye dogs,...

  15. 31 CFR 91.11 - Dogs and other animals.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ...Treasury 1 2012-07-01 2012-07-01 false Dogs and other animals. 91.11 Section 91.11...BUREAU OF THE MINT BUILDINGS AND GROUNDS § 91.11 Dogs and other animals. Dogs and other animals, except seeing-eye dogs,...

  16. 36 CFR 520.11 - Dogs and other animals.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ...Property 3 2012-07-01 2012-07-01 false Dogs and other animals. 520.11 Section 520.11...PARK OF THE SMITHSONIAN INSTITUTION § 520.11 Dogs and other animals. Dogs and other animals, except seeing-eye dogs,...

  17. 36 CFR 520.11 - Dogs and other animals.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ...Property 3 2014-07-01 2014-07-01 false Dogs and other animals. 520.11 Section 520.11...PARK OF THE SMITHSONIAN INSTITUTION § 520.11 Dogs and other animals. Dogs and other animals, except seeing-eye dogs,...

  18. 36 CFR 504.10 - Dogs and other animals.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ...Property 3 2012-07-01 2012-07-01 false Dogs and other animals. 504.10 Section 504.10...SMITHSONIAN INSTITUTION BUILDINGS AND GROUNDS § 504.10 Dogs and other animals. Dogs and other animals, except seeing-eye dogs,...

  19. 4 CFR 25.12 - Dogs and other animals.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ...Accounts 1 2013-01-01 2013-01-01 false Dogs and other animals. 25.12 Section 25.12...ACCOUNTABILITY OFFICE BUILDING AND ON ITS GROUNDS § 25.12 Dogs and other animals. Dogs and other animals, except seeing eye dogs or...

  20. Gather information and determine the best dog for

    E-print Network

    New Hampshire, University of

    Gather information and determine the best dog for your family . Learn about proper care, grooming, and feeding of your dog. Create a plan to prevent your dog from getting lost and/or finding it if it gets lost. Purchase and use the appro- priate grooming equipment and techniques. Train your dog basic com

  1. 4 CFR 25.12 - Dogs and other animals.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ...Accounts 1 2012-01-01 2012-01-01 false Dogs and other animals. 25.12 Section 25.12...ACCOUNTABILITY OFFICE BUILDING AND ON ITS GROUNDS § 25.12 Dogs and other animals. Dogs and other animals, except seeing eye dogs or...

  2. 4 CFR 25.12 - Dogs and other animals.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ...Accounts 1 2014-01-01 2013-01-01 true Dogs and other animals. 25.12 Section 25.12...ACCOUNTABILITY OFFICE BUILDING AND ON ITS GROUNDS § 25.12 Dogs and other animals. Dogs and other animals, except seeing eye dogs or...

  3. 31 CFR 407.11 - Dogs and other animals.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ...Treasury 2 2012-07-01 2012-07-01 false Dogs and other animals. 407.11 Section 407.11...TREASURY BUILDING AND THE TREASURY ANNEX § 407.11 Dogs and other animals. Dogs and other animals, except seeing-eye dogs,...

  4. 36 CFR 504.10 - Dogs and other animals.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ...Property 3 2013-07-01 2012-07-01 true Dogs and other animals. 504.10 Section 504.10...SMITHSONIAN INSTITUTION BUILDINGS AND GROUNDS § 504.10 Dogs and other animals. Dogs and other animals, except seeing-eye dogs,...

  5. 31 CFR 91.11 - Dogs and other animals.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ...Treasury 1 2014-07-01 2014-07-01 false Dogs and other animals. 91.11 Section 91.11...BUREAU OF THE MINT BUILDINGS AND GROUNDS § 91.11 Dogs and other animals. Dogs and other animals, except seeing-eye dogs,...

  6. 31 CFR 91.11 - Dogs and other animals.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ...Treasury 1 2013-07-01 2013-07-01 false Dogs and other animals. 91.11 Section 91.11...BUREAU OF THE MINT BUILDINGS AND GROUNDS § 91.11 Dogs and other animals. Dogs and other animals, except seeing-eye dogs,...

  7. 31 CFR 407.11 - Dogs and other animals.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ...Treasury 2 2013-07-01 2013-07-01 false Dogs and other animals. 407.11 Section 407.11...TREASURY BUILDING AND THE TREASURY ANNEX § 407.11 Dogs and other animals. Dogs and other animals, except seeing-eye dogs,...

  8. 31 CFR 407.11 - Dogs and other animals.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ...Treasury 2 2014-07-01 2014-07-01 false Dogs and other animals. 407.11 Section 407.11...TREASURY BUILDING AND THE TREASURY ANNEX § 407.11 Dogs and other animals. Dogs and other animals, except seeing-eye dogs,...

  9. A Simple Genetic Architecture Underlies Morphological Variation in Dogs

    E-print Network

    Paris-Sud XI, Université de

    A Simple Genetic Architecture Underlies Morphological Variation in Dogs Adam R. Boyko1,2. , Pascale, United States of America Abstract Domestic dogs exhibit tremendous phenotypic diversity, including of canine genetic variation by genotyping 915 dogs from 80 domestic dog breeds, 83 wild canids, and 10

  10. Animal Health Diagnostic Center Lyme Disease Multiplex Testing for Dogs

    E-print Network

    Keinan, Alon

    Animal Health Diagnostic Center Lyme Disease Multiplex Testing for Dogs Background on Lyme disease and Lyme diagnostics in dogs Lyme disease is induced by the spirochete B. burgdorferi. Spirochetes are transmitted to dogs by infected ticks. Similar to humans, dogs are incidental, dead-end hosts for B

  11. The Dog as a Model for Food Allergy

    Microsoft Academic Search

    BOB B. BUCHANANa

    Research during the past decade has shown the dog to be an ex- cellent model for human food allergies. Humans and dogs share many of the same allergies to foods. Furthermore, the dog model shows clinical symptoms typical of humans, that is, both experience vomiting and diar- rhea. Present results suggest that the dog may provide a means to test

  12. The Dog as a Model for Food Allergy

    Microsoft Academic Search

    Bob B. Buchanan; Oscar L. Frick

    2002-01-01

    ABSTRACT: Research during the past decade has shown the dog to be an ex- cellent model for human,food allergies. Humans and dogs share many of the same allergies to foods. Furthermore, the dog model shows clinical symptoms typical of humans, that is, both experience vomiting and diar- rhea. Present results suggest that the dog may ,provide a means ,to test

  13. Identification of telomerase in dog 

    E-print Network

    Lyuksyutova, Anna

    2013-02-22

    map and multiple cloning site. . . . . . Southern blot cTR probe preparation. Restriction digest of pUC 19 Pst I clones with Pst I . Amplification by PRC of cTR fragment from pUC 19 Pst I clones . . . Amplification by PCR of cTR from dog genomic... with Qiagen QIAprep Spin Miniprep Kit (Qiagen, ?27104). The isolated clone's DNA was screened by PCR and restriction digest with EcoRI for the presence of the cTR gene (see Fig. 5 and Fig. 6). Bi D ee Se uencin ABI PE-ABI?4303150. 30 pmoles of primer, 400...

  14. Systemic reactive angioendotheliomatosis-like syndrome in a steer presumed to be persistently infected with bovine viral diarrhea virus.

    PubMed

    Breshears, M A; Johnson, B J

    2008-09-01

    Unusual proliferative intravascular lesions were seen in multiple organs of a 2-year-old Corriente steer presumed to be persistently infected with bovine viral diarrhea virus (BVDV), based on widespread immunohistochemical detection of BVDV antigen. Proliferations of spindle cells, which were immunohistochemically positive for von Willebrand factor-related antigen, partially-to-completely occluded vessel lumens and were supported by cells that were immunohistochemically positive for smooth muscle actin. Distribution and character of the intraluminal proliferations are strikingly similar to those described in feline systemic reactive angioendotheliomatosis, a rare entity of unknown cause. The presence of occasional intravascular thrombi suggests that the proliferative vasculopathy was associated with an underlying thrombotic process with immunohistochemical similarities to thrombotic thrombocytopenic purpura of humans. Death of the steer was due to hemorrhage from a castration wound, which may indicate thrombocytopenia or platelet dysfunction. The role of persistent BVDV infection in the formation of the intravascular lesions is unknown. PMID:18725468

  15. Decline in human dog-bite cases during a street dog sterilisation programme in Jaipur, India.

    PubMed

    Reece, J F; Chawla, S K; Hiby, A R

    2013-05-01

    Human dog-bite injuries are a major public health problem, particularly where there are large populations of free-roaming or street dogs. Dog bites are also the major source of human rabies infections. There is little information on the means to reduce these injuries. Monthly human animal-bite injury records from January 2003 to June 2011 were obtained from the main government hospital in Jaipur, India. The data were analysed and compared with records of pregnancy in street dogs in Jaipur obtained from a street dog sterilisation programme. Human animal-bite injuries showed a seasonal pattern which followed by approximately 10 weeks the seasonal peak of street dog breeding. The number of human animal bites has declined significantly since 2003. It is concluded that a street dog sterilisation programme can reduce human dog-bite injuries by reducing the maternal protective behaviour of the street dogs, as well as reducing the total size of the roaming dog population. PMID:23492927

  16. A two-year follow-up of neonates with presumed sepsis treated with recombinant human granulocyte colony-stimulating factor during the first week of life

    Microsoft Academic Search

    Joseph Rosenthal; Timothy Healey; Robin Ellis; Eileen Gillan; Mitchell S. Cairo

    1996-01-01

    We have previously reported that recombinant human granulocyte colony-stimulating factor was well tolerated and resulted in sustained neutrophilia and improvement of neutrophil functions in newborn infants with presumed sepsis. We now report a 2-year follow-up on 21 of the initial cohort of 28 patients. Treatment with recombinant human granulocyte colony-stimulating factor in neonates with presumed sepsis was not associated with

  17. Neuronal ceroid lipofuscinosis in the Polish Owczarek Nizinny (PON) dog

    Microsoft Academic Search

    Anders Wrigstad; Sven Erik G. Nilsson; Richard Dubielzig; Kristina Narfström

    1995-01-01

    Visual dysfunction and neurological symptoms were found in Polish Owczarek Nizinny (PON) dogs. Two dogs were examined, one at 2 years of age and the other one at 4 years. The oldest dog was totally blind. The 2-year-old dog developed mental disturbances and the 4-year-old dog became severely ataxic. Ophthalmoscopical findings were retinal hyper-reflectivity, attenuation of the retinal vessels and

  18. Mortality of purebred and mixed-breed dogs in Denmark

    Microsoft Academic Search

    Helle Friis Proschowsky; Helene Rugbjerg; Annette Kjćr Ersbřll

    2003-01-01

    Causes of death and age at death of 2928 dogs are reported from a questionnaire study among members of the Danish Kennel Club (DKC) in 1997. The dogs represented 20 breeds, 15 breed-groups and a group of mixed-breed dogs. The median age at death for all dogs in the study was 10.0 years. Mixed-breed dogs had a higher median age

  19. Comparative map between the domestic pig and dog

    Microsoft Academic Search

    L. S. Biltueva; F. Yang; N. V. Vorobieva; A. S. Graphodatsky

    2004-01-01

    Cross-species chromosome painting with probes derived from flow-sorted dog and human chromosomes was used to construct a high-resolution comparative map for the pig. In total 98 conserved autosomal segments between pig and dog were detected by probes specific for the 38 autosomes and X Chromosome of the dog. Further integration of our results with the published human–dog and cat–dog comparative

  20. Tertiary hypothyroidism in a dog

    PubMed Central

    2007-01-01

    A nine-year-old male entire Labrador was diagnosed with pituitary dependent hyperadrenocorticism. Following seven months of successful mitotane therapy, the dog presented with marked weight gain, seborrhoea and alopecia. Routine clinicopathological analyses revealed marked hypercholesterolaemia. Serum total and free thyroxine (T4) concentrations were below their respective reference ranges. Serum thyroid stimulating hormone (cTSH) concentration was within reference range. TSH and thyrotropin releasing hormone (TRH) response tests revealed adequate stimulation of total T4 in both, and cTSH in the latter test. Magnetic resonance imaging revealed a mass arising from the pituitary fossa, with suprasellar extension. A diagnosis of tertiary hypothyroidism was made. Following four weeks of levothyroxine therapy, circulating cholesterol concentration had declined, weight loss had ensued and dermatological abnormalities had improved. Euthanasia was performed four months later due to the development of neurological signs. A highly infiltrative pituitary adenoma, with effacement of the overlying hypothalamus was identified on post mortem examination. Tertiary hypothyroidism has not been previously reported in dogs. PMID:21851691

  1. Social referencing in dog-owner dyads?

    PubMed

    Merola, I; Prato-Previde, E; Marshall-Pescini, S

    2012-03-01

    Social referencing is the seeking of information from another individual to form one's own understanding and guide action. In this study, adult dogs were tested in a social referencing paradigm involving their owner and a potentially scary object. Dogs received either a positive or negative message from the owner. The aim was to evaluate the presence of referential looking to the owner, behavioural regulation based on the owner's (vocal and facial) emotional message and observational conditioning following the owner's actions towards the object. Most dogs (83%) looked referentially to the owner after looking at the strange object, thus they appear to seek information about the environment from the human, but little differences were found between dogs in the positive and negative groups as regards behavioural regulation: possible explanations for this are discussed. Finally, a strong effect of observational conditioning was found with dogs in the positive group moving closer to the fan and dogs in the negative group moving away, both mirroring their owner's behaviour. Results are discussed in relation to studies on human-dog communication, attachment and social learning. PMID:21874515

  2. An investigation on the presence of Chlamydiaceae in Swedish dogs

    PubMed Central

    2010-01-01

    Background Bacteria belonging to the family Chlamydiaceae cause a broad spectrum of diseases in a wide range of hosts, including man, other mammals, and birds. Upper respiratory and genital diseases are common clinical problems caused by Chlamydiaceae. Very little is known about chlamydial infections in dogs. Few clinical reports on natural disease in dogs describe mainly conjunctival and upper respiratory signs, and the role of Chlamydiaceae in genital disease is unclear. The present study aimed at studying the prevalence of Chlamydiaceae in healthy dogs and in dogs with genital or upper respiratory disease, including conjunctivitis. Methods A real-time polymerase chain reaction (PCR) for Chlamydiaceae was used to detect any chlamydial species within this family. Swab samples from the conjunctiva and the mucosal membranes of the oropharynx, rectum and genital tract were taken from 79 dogs: 27 clinically healthy dogs, 25 dogs with clinical signs from the genital tract and 28 dogs with conjunctivitis. There were 52 female and 27 male dogs. From 7 of the male dogs, additional semen samples were analysed. Results No Chlamydiaceae were detected from any dog. Conclusions Although the number of dogs that was included is limited, the results suggest that cases of Chlamydiaceae in dogs probably are related to infection from other species, and that dogs in general do not harbour Chlamydiaceae. Bacteria belonging to the family Chlamydiaceae do not seem to be of major importance for genital or ocular disease in Swedish dogs. PMID:21078208

  3. Cardiovascular alterations in dogs treated with hydralazine.

    PubMed

    Mesfin, G M; Shawaryn, G G; Higgins, M J

    1987-01-01

    Groups of 5 male beagle dogs were treated orally with hydralazine tablets in gelatin capsules at a dose of 12 or 24 mg/kg twice a day (6 hours apart) for 2 consecutive days. Five male dogs treated with empty gelatin capsules served as untreated controls. Clinical findings and heart rate changes during treatment and terminal body weight, hematology, and blood chemistry changes were evaluated. The heart, liver, kidneys, spleen, and thymus of each animal were examined microscopically. Dogs in the 12 mg/kg group ate less than control group. Dogs treated with 24 mg/kg did not eat and vomited. Heart rates in both of the treated groups increased by 60% to 80% within 2 hours of treatment and remained high during the entire treatment period. Significant hematologic change was confined to a slight increase in platelet number of dogs treated with 24 mg/kg. Serum glucose was increased in the hydralazine treated dogs. Conjugated serum bilirubin was increased and serum potassium, chloride and phosphorus were decreased in the 24 mg/kg group. Blood urea nitrogen and serum chloride were slightly increased in dogs treated with 12 mg/kg. Treatment-related pathologic alterations were confined to the heart. Two dogs from each of the hydralazine groups experienced acute localized hemorrhage into the epicardium and subepicardium of the right atrium. The media of the muscular branches of the coronary arteries, especially the left coronary artery, was hemorrhagic in 3 dogs from the 24 mg/kg group. Medial necrosis, when seen, tended to be proportional to the severity of medial hemorrhages. There was no necrosis in the papillary muscles of the heart.(ABSTRACT TRUNCATED AT 250 WORDS) PMID:3432940

  4. Gastritis in Alaskan racing sled dogs.

    PubMed

    Ritchey, J W; Davis, M S; Breshears, M A; Willard, M D; Williamson, K K; Royer, C M; Payton, M E; Cragun, A S

    2011-07-01

    Alaskan racing sled dogs are a well-established model of exercise-induced gastric disease. The aim of this study was to define the temporal development of microscopical gastric lesions during long distance racing. Two groups of dogs were examined: group I comprised conditioned dogs that were exercising and group II were conditioned dogs not exercising. The gastric mucosa was examined endoscopically and sampled for routine histopathology and microscopical scoring, immunohistochemistry (IHC) and detection of apoptotic epithelial cells. Overall, group I dogs exhibited more significant epithelial lesions, including ulcers, compared with dogs in group II. Group II dogs exhibited the most severe mucosal inflammatory infiltrates. Although the intensity of inflammation differed, the nature of the inflammation was similar between groups, consisting of diffuse lymphocytic infiltration and a unique interface-type infiltrate that obscured the basement membrane zone and was accompanied by intraepithelial infiltration of lymphocytes. IHC confirmed the presence of CD3(+) T and CD79(+) B lymphocytes within the mucosal infiltrates; however, most of the intraepithelial and interface infiltrates were CD3(+) T cells. Spiral-shaped bacterial organisms were seen in the gastric tissues; however, their presence did not correlate with either the severity of epithelial lesions, inflammation or the pattern of interface inflammation. The number of apoptotic epithelial cells was widely variable and not significantly different between groups. These findings confirm previous observations that gastric ulcers develop in conditioned dogs under racing stress. The unique nature of the interface-type gastric inflammation is similar to that of human lymphocytic gastritis and may suggest an immune-mediated mechanism for the changes seen in Alaskan racing sled dogs. PMID:21247587

  5. Alterations of lymphocyte subpopulations in healthy dogs with aging and in dogs with cancer

    Microsoft Academic Search

    Ai Watabe; Shinya Fukumoto; Takahiro Komatsu; Yoshifumi Endo; Tsuyoshi Kadosawa

    2011-01-01

    Changes in an individual's immune status are considered major contributing factors towards the morbidity of cancer and mortality of aging. To evaluate age-related changes in the immune status of dogs, the immunophenotypes (CD3, CD4, CD8 and CD21) of peripheral blood lymphocytes were measured in 160 healthy dogs aged from 1 to 17 years, and in 365 dogs with various tumors

  6. Discrimination of human and dog faces and inversion responses in domestic dogs (Canis familiaris)

    Microsoft Academic Search

    Anaďs Racca; Eleonora Amadei; Séverine Ligout; Kun Guo; Kerstin Meints; Daniel Mills

    2010-01-01

    Although domestic dogs can respond to many facial cues displayed by other dogs and humans, it remains unclear whether they\\u000a can differentiate individual dogs or humans based on facial cues alone and, if so, whether they would demonstrate the face\\u000a inversion effect, a behavioural hallmark commonly used in primates to differentiate face processing from object processing.\\u000a In this study, we

  7. Neophilia in domestic dogs (Canis familiaris) and its implication for studies of dog cognition.

    PubMed

    Kaulfuss, Patricia; Mills, Daniel S

    2008-07-01

    This study examined novel-object preference in dogs. In a free choice test 17 dogs were presented with a novel toy in a line up with two familiar toys. The unfamiliar object was chosen first in 38 out 50 tests suggesting a strong preference for novel over familiar items. Neophilia may be an adaptive trait for domestic dogs that has helped their adaptation towards man. PMID:18183436

  8. Neophilia in domestic dogs ( Canis familiaris ) and its implication for studies of dog cognition

    Microsoft Academic Search

    Patricia Kaulfuß; Daniel S. Mills

    2008-01-01

    This study examined novel-object preference in dogs. In a free choice test 17 dogs were presented with a novel toy in a line\\u000a up with two familiar toys. The unfamiliar object was chosen first in 38 out 50 tests suggesting a strong preference for novel\\u000a over familiar items. Neophilia may be an adaptive trait for domestic dogs that has helped

  9. Comparison of the nutrient composition of commercial dog milk replacers with that of dog milk

    PubMed Central

    Heinze, Cailin R.; Freeman, Lisa M.; Martin, Camilia R.; Power, Michael L.; Fascetti, Andrea J.

    2015-01-01

    Objective To compare the nutrient composition of commercially available dog milk replacers with that of dog milk. Design Prospective, cross-sectional study. Sample 5 dog milk samples and 15 samples of commercial dog milk replacers. Procedures Dog milk and milk replacers were analyzed for concentrations of total protein, essential amino acids, sugars, total fat, essential fatty acids, calcium, and phosphorus. Energy density was calculated. Results from milk replacers were compared with the range of the concentration of each nutrient in milk samples from mature dogs as well as the National Research Council (NRC) recommendations for puppy growth. Results Milk replacers varied widely in caloric density and concentration of nutrients such as calcium, protein, and fat. Calcium concentration was lower in 14 of 15 milk replacers than in the dog milk samples. Docosahexaenoic acid was undetectable in 12 of 15 milk replacers but present in all dog milk samples. All milk replacers had numerous essential nutrients outside of the range of the dog milk samples, and many had concentrations of amino acids, essential fatty acids, calcium, and phosphorus less than the NRC minimal requirement or recommended allowance. Compared with NRC recommendations, some dog milk samples had concentrations of total protein, linoleic acid, calcium, or phosphorus less than the recommended allowance. Conclusions and Clinical Relevance Results suggested that there was substantial variation in nutrient composition of 15 dog milk replacers and that some products were closer approximations of dog milk than others. Nearly all products would benefit from more appropriate calcium, amino acids, and essential fatty acids concentrations and better feeding directions. PMID:24871064

  10. The response of guide dogs and pet dogs ( Canis Familiaris ) to cues of human referential communication (pointing and gaze)

    Microsoft Academic Search

    Miriam Ittyerah; Florence Gaunet

    2009-01-01

    The study raises the question of whether guide dogs and pet dogs are expected to differ in response to cues of referential\\u000a communication given by their owners; especially since guide dogs grow up among sighted humans, and while living with their\\u000a blind owners, they still have interactions with several sighted people. Guide dogs and pet dogs were required to respond

  11. Salmonella organisms in mature, healthy dogs 

    E-print Network

    Jungerman, Paul F

    1959-01-01

    reporte4 in dogs, 15 ~ 17 Galton eC ~s ' showed that 4ogs mainCaina4 tn clean surroundings might easily become tnfsetsd from contaminated food. Salmonella were isolaCa4 from twenty stn of ntnsty~ght samples of dog @mal tested. A publication by Moore... Lactose Negative Calturas 15 to Shm Urease Activity oo Urea Agar SALMONELLA OSGANISNS IN ~, HLALXHY DOGS INTNSDIRTION Salmonella organisms cause disease in msu, in poultry and birds and in amst species of domestic and wild animals. The wide range...

  12. Dog bites: a complex public health issue.

    PubMed

    Orritt, Rachel

    2015-06-20

    The first 'UK Dog Bite Prevention Week' was introduced on June 6 and 7 with a two-day conference hosted by television presenter and dog trainer Victoria Stilwell in association with the University of Lincoln. The event attracted a mix of academic and professional speakers as well as delegates from a wide range of backgrounds. Rachel Orritt, who is researching the perceptions, assessment and management of human-directed aggressive behaviour in dogs at the University of Lincoln, reports on the proceedings. PMID:26101383

  13. Fecal Microbiome in Dogs with Acute Diarrhea 

    E-print Network

    Guard, Blake Crosby

    2013-11-07

    American collie FS NHD4 1 Brittany spaniel M NHD5 6 Basset hound FS AHD1 7 Labrador MN AHD2 1 Brittany spaniel MN AHD3 5 Bulldog MN AHD4 3 Shetland sheepdog FS AHD5 2 Dachshund F AHD6 10 American Pit Bull terrier MN H = Healthy dogs; NHD = dogs... 21 Table 1. Signalment for dogs enrolled in the study. Animal ID Age (years) Breed Sex and sexual status H1 3 Labrador MN H2 7 Boston terrier mix MN H3 9 Labrador FS H4 5 German shepherd FS H5 3 Australian Kelpie F H6 1...

  14. Nutrition for working and service dogs.

    PubMed

    Wakshlag, Joseph; Shmalberg, Justin

    2014-07-01

    Conformation, genetics, and behavioral drive are the major determinants of success in canine athletes, although controllable variables, such as training and nutrition, play an important role. The scope and breadth of canine athletic events has expanded dramatically in the past 30 years, but with limited research on performance nutrition. There are considerable data examining nutritional physiology in endurance dogs and in sprinting dogs; however, nutritional studies for agility, field trial, and detection are rare. This article highlights basic nutritional physiology and interventions for exercise, and reviews newer investigations regarding aging working and service dogs, and canine detection activities. PMID:24951343

  15. Fleas parasitizing domestic dogs in Spain.

    PubMed

    Gracia, M J; Calvete, C; Estrada, R; Castillo, J A; Peribáńez, M A; Lucientes, J

    2008-02-14

    In addition to their importance to veterinary clinical practice as ectoparasites, fleas of domestic dogs are of special concern because they can be vectors of disease, including zoonoses. Flea assemblages parasitizing domestic dogs usually comprise several flea species whose distribution is determined by factors acting at several scales. Knowledge of these factors will aid in assessment of the distribution patterns of flea parasitism, and is an important tool in developing control strategies and in evaluation of flea-borne disease risk in dogs and humans. In this survey we used data from 744 domestic dogs from 79 localities in Spain to explore the associations between the abundance of flea species, host-dependent factors (sex and age), and host habitat factors including abode (farm, house with garden, apartment), location (urban or rural), the presence of other pets, and dog activity (measured as the frequency with which dogs left their abode). We also considered environmental factors including the time of year and mean annual temperature and rainfall. Variations in flea community structure at infracommunity and component community levels were also explored. Four flea species were found parasitizing dogs. Ctenocephalides felis was the most abundant (88.02% of fleas identified), followed by Ctenocephalides canis (10.38%), Pulex irritans (1.47%) and Echidnophaga gallinacea (0.13%). Overall flea abundance was higher on dogs living on farms than in apartments, as was the abundance of Ct. felis, Ct. canis and P. irritans. Ct. felis was more abundant on dogs living in houses than in apartments, but the reverse was found for P. irritans. Overall flea abundance and Ct. canis abundance were highest in rural areas, whereas the presence of other pets sharing the abode was associated with higher overall flea abundance and Ct. felis abundance. Only P. irritans abundance was positively related to the activity of dogs. Ct. canis and P. irritans abundances were higher during the warm period of the year. Mean annual temperature was negatively correlated with overall, Ct. canis and P. irritans abundances, but positively related to Ct. felis abundance. Annual rainfall was negatively correlated with Ct. canis and P. irritans abundances. Variations in the number of flea species found on a dog reflected the abundance distribution patterns for each species and their associations with host habitat and environmental factors. At the component community level, flea species richness was inversely related to annual mean temperature. The structure of flea assemblages on dogs was mainly associated with host habitat and environmental variables, and not with host-dependent variables. However, a large amount of variation in flea abundance remained unexplained, suggesting the effect of other non-controlled factors. PMID:18031934

  16. Evaluation of the shock index in dogs presenting as emergencies

    PubMed Central

    Porter, Adam E.; Rozanski, Elizabeth A.; Sharp, Claire R.; Dixon, Kursten L.; Lyn Price, Lori; Shaw, Scott P.

    2013-01-01

    Objectives To 1) determine the normal range for Shock Index (SI) [defined as heart rate (HR)/systolic blood pressure (SBP)], in healthy dogs, and 2) compare SI in healthy dogs with dogs presenting to the emergency room (ER) deemed to be in or not in a state of shock. Design Prospective study. Animals 68 clinically normal dogs,,18 dogs that were presented to the ER deemed to be in shock and 19 dogs presenting to the ER not deemed to be in shock. Setting University teaching hospital. Interventions Peripheral or central venous blood sampling. Measurements and Main Results Heart rate and SBP were recorded on simulated presentation (healthy dogs), and emergency presentations for both dogs deemed to be in shock and dogs not deemed in shock. Dogs in shock had a median SI of 1.37 (0.87–3.13), which was significantly higher than both other groups; dogs not deemed in shock had median SI 0.73 (0.56–1.20), P<0.0001 and healthy dogs had median SI 0.78 (0.37–1.30) P<0.0001), respectively. Receiver operator characteristic curve analysis suggested a SI cut-off of 1.0, yielding an area under the receiver operator characteristic (AUROC) of 0.89 (Specificity (Sp) 89, Sensitivity (Sn) 90) when comparing dogs deemed in shock with healthy dogs, and 0.92 (Sp 95, Sn 89) when comparing dogs in shock with to dogs not deemed in shock. Conclusions The SI is an easy and non-invasive patient parameter that is higher in dogs that are deemed to be in shock than both healthy dogs and dogs presented as emergencies but not deemed to be in a state of shock. The measurement of SI may have some benefit in clinical assessment of emergency patients. PMID:23855723

  17. [Hepatitis in dogs; a review].

    PubMed

    Rothuizen, J; van den Ingh, T S

    1998-04-15

    As with most liver diseases, the symptoms of hepatitis in dogs are nearly always aspecific: the dogs eat less, are apathetic, sometimes have polyuria/polydipsia, and sometimes have diarrhoea. Hepatoencephalopathy and ascites only occur with these symptoms in very advanced stages of chronic hepatitis. Only a part of the dogs have jaundice. Because of these aspecific symptoms, the diagnosis hepatitis is often not taken into consideration, even though the presence of a liver disease can be easily detected by measuring plasma concentrations of alkaline phosphatase and bile acids, one or both of which are elevated. The diagnosis is confirmed by histological examination of a liver biopsy sample. The most common forms of hepatitis are non-specific reactive hepatitis, acute hepatitis, and chronic hepatitis. Non-specific reactive hepatitis is a reaction against endotoxin as a result of sepsis or an increased gastrointestinal absorption. Treatment is directed to the primary process. Leptospirosis also causes non-specific reactive hepatitis, but then renal insufficiency is the most prominent feature. The diagnosis is made not on the basis of a liver biopsy but on the basis of increased IgM titres against Leptospira. Immediate treatment with antibiotics and infusions at the first signs (jaundice and uraemia) can save the animal's life. Acute hepatitis can develop as a result of infection, toxins, or liver hypoxia. There is no specific treatment, but adequate recovery often occurs with supportive treatment. Corticosteroids are contraindicated. Chronic hepatitis, which can lead to cirrhosis, is the most common form of hepatitis. It is an autoimmune inflammatory reaction that is usually caused by a virus infection but sometimes by poisoning (intoxication). Long treatment with prednisolone or azathioprine is usually successful, but early recognition of the disease increases the likelihood of success. Nowadays, chronic hepatitis due to hepatic copper accumulation in Beddlington terriers can be detected by DNA tests. Such tests make it possible to distinguish between carriers and non-carriers. Affected animals can be kept symptom-free by life-long treatment with zinc gluconate or penicillamine. PMID:9584348

  18. Factors Involved in Search Dog Training 

    E-print Network

    Alexander, Michael B.

    2010-07-14

    Events of significant impact as recent as hurricane Ike yielded a consistent disturbing truth: we lack sufficient numbers of competent search dog [Canis familiaris] teams. This study was conceived to provide information in identifying factors...

  19. In Vitro Culture of 'Dog Ridge' Grapevine 

    E-print Network

    Wong, Kah-Yat Isaac

    2009-06-09

    Vitis champini ‘Dog Ridge’ grapevine is a potentially desirable rootstock for Texas grapevines because of its disease resistance. This selection is reported to be difficult to root through hardwood cuttage as is often practiced for grapevine. A...

  20. Theileria annae in a young Swedish dog

    PubMed Central

    2013-01-01

    A severe regenerative anemia was detected in a 12-week-old mixed breed puppy in Sweden. A small protozoan parasite was observed in erythrocytes on a blood smear. It was initially suspected to be Babesia gibsoni based on its size and because B. gibsoni was previously recorded in Sweden. Surprisingly, specific polymerase chain reaction analysis identified the protozoan as Theileria annae. T. annae is endemic in Northwest Spain, is very uncommonly reported elsewhere and has never been recorded in Scandinavia. T. annae has been identified in dogs used for dog fighting, and it is thought to be transmitted by dog bites. This puppy was a mixed pit bull terrier. Pit bull terriers are sometimes used for dog fighting. T. annae has been reported to be transmitted vertically, and in light of the puppy’s age, this transmission was suspected in the present case. PMID:23842507

  1. Theileria annae in a young Swedish dog.

    PubMed

    Falkenö, Ulrika; Tasker, Séverine; Osterman-Lind, Eva; Tvedten, Harold W

    2013-01-01

    A severe regenerative anemia was detected in a 12-week-old mixed breed puppy in Sweden. A small protozoan parasite was observed in erythrocytes on a blood smear. It was initially suspected to be Babesia gibsoni based on its size and because B. gibsoni was previously recorded in Sweden. Surprisingly, specific polymerase chain reaction analysis identified the protozoan as Theileria annae. T. annae is endemic in Northwest Spain, is very uncommonly reported elsewhere and has never been recorded in Scandinavia. T. annae has been identified in dogs used for dog fighting, and it is thought to be transmitted by dog bites. This puppy was a mixed pit bull terrier. Pit bull terriers are sometimes used for dog fighting. T. annae has been reported to be transmitted vertically, and in light of the puppy's age, this transmission was suspected in the present case. PMID:23842507

  2. The March of the robot dogs

    Microsoft Academic Search

    Robert Sparrow

    2002-01-01

    Following the success of Sony Corporation's`AIBO,' robot cats and dogs are multiplyingrapidly. ``Robot pets'' employing sophisticatedartificial intelligence and animatronictechnologies are now being marketed as toys andcompanions by a number of large consumerelectronics corporations.

  3. Dogs’ use of the solidity principle – revisited

    PubMed Central

    Müller, Corsin A.; Riemer, Stefanie; Range, Friederike; Huber, Ludwig

    2014-01-01

    A wealth of comparative data has been accumulated over the past decades on how animals acquire and use information about the physical world. Domestic dogs have typically performed comparably poorly in physical cognition tasks, though in a recent study Kundey and colleagues (2010) challenged this view and concluded that dogs understand that objects cannot pass through solid barriers. However, the eight subjects in the study of Kundey et al. may have solved the task with the help of perceptual cues, which had not been controlled for. Here, we tested dogs with a similar task that excluded these cues. In addition, unlike the setup of Kundey et al., our setup allowed the subjects to observe the effect of the solid barrier. Nevertheless, all 28 subjects failed to solve this task spontaneously, and showed no evidence of learning across 50 trials. Our results therefore call into question the earlier suggestion that dogs have, or can acquire, an understanding of the solidity principle. PMID:24253452

  4. Perineal hernia repair in dogs.

    PubMed

    Robertson, J J

    1984-05-01

    Old male Collies, Pekingese , Boxers and Boston Terriers are predisposed to perineal hernia. Recurrence is often related to poor surgical technic in the initial repair. With the anesthetized dog in sternal recumbency and the tail tied forward, a curvilinear skin incision is made over the hernia, from the tail base to the midline, ventral to the anus. The hernial sac is opened and its contents reduced. Five stainless-steel sutures are preplaced in the muscles and ligaments of the perineal diaphragm and tied from top to bottom. In cases of failure of the ventral aspect of the repair, the internal obturator muscle can be elevated from the ischial table and used to cover the ventral aspect of the hernia. Postoperative complications are related to infection, self-trauma and straining. PMID:6738509

  5. Pathology Case Study: Dog Bites

    NSDL National Science Digital Library

    Driscoll, Eileen

    This is a case study presented by the University of Pittsburgh Department of Pathology, which describes a 56-year-old male with a past medical history significant for lymphoma (in remission). The patient is a health care worker who presented to the emergency room because of a dog bite. Visitors are given a patient history and culture findings, including images. They are also given an opportunity to diagnose the patient before clicking on the "Final Diagnosis" section, which provides a discussion of the findings as well as references. This is an excellent resource for students in the health sciences to familiarize themselves with using patient history and laboratory results to diagnose disease. It is also a helpful site for educators to use to introduce or test student learning in clinical microbiology.

  6. Disseminated pseudallescheriosis in a dog.

    PubMed

    Elad, D; Perl, S; Yamin, G; Blum, S; David, D

    2010-06-01

    A case of disseminated pseudallescheriasis in a German Shepherd bitch is presented. Bones (ilium, a rib and phalanges), joints (elbow and acetabulum) and the surrounding tissues were the principal organs affected. In addition, Pseudallescheria boydii was isolated, in lower numbers, from the eye, kidney, lymph nodes draining the affected regions and urine. The dog was euthanized. P. boydii was identified by morphologic characteristics and molecular techniques (beta tubulin sequence). In addition, an ITS nucleotide sequence analysis showed that this strain differed from another isolate identified as Scedosporium apiospermum that had caused a disseminated infection in another German Shepherd. The importance of the molecular characterization of fungi belonging to the Pseudallescheria/Scedosporium complex, isolated from animals is stressed in light of the ongoing attempts to recharacterize these fungi. PMID:19886774

  7. Metastasizing Esthesioneuroblastoma in a Dog.

    PubMed

    Siudak, K; Klingler, M; Schmidt, M J; Herden, C

    2015-07-01

    A 7-year-old Afghan hound presented with a history of disorientation, loss of vision, and seizures. Magnetic resonance imaging helped identify a mass at the level of the main olfactory bulb that compressed and displaced adjacent tissues in the cribriform plate into the nasal cavity and nasopharynx. Bony structures were osteolytic. After removing almost 80% of the mass, the tumor recurred a few months later. Due to severe respiratory distress and subsequent to an ultrasound diagnosis of a liver tumor, the dog was euthanized. In addition to the nasal mass, a single nodule in the liver and multiple nodules in the lung were present. All masses had similar cell morphology and were diagnosed as metastasizing esthesioneuroblastoma. The neoplastic cells expressed neuron-specific enolase and chromogranin A, and a few cells within the nasal mass were positive for cytokeratin. This is the first description of a canine esthesioneuroblastoma with distant metastases. PMID:25428407

  8. Comparison of P-wave dispersion in healthy dogs, dogs with chronic valvular disease and dogs with disturbances of supraventricular conduction

    PubMed Central

    2011-01-01

    Background P-wave dispersion (Pd) is a new ECG index used in human cardiology and veterinary medicine. It is defined as the difference between the maximum and the minimum P-wave duration recorded from multiple different ECG leads. So far no studies were performed assessing the importance of P-wave dispersion in dogs. Methods The current study was aimed at determining proper value of Pd in healthy dogs (group I), dogs with chronic valvular disease (group II) and dogs with disturbances of supraventricular conduction (group III). The tests were carried out in 53 healthy dogs, 23 dogs with chronic valvular disease and 12 dogs with disturbances of supraventricular conduction of various breeds, sexes and body weight from 1,5 to 80 kg, aged between 0,5 and 17 years, submitted to the ECG examination. ECG was acquired in dogs in a standing position with BTL SD-8 electrocardiographic device and analyzed once the recording was enlarged. P-wave duration was calculated in 9 ECG leads (I, II, III, aVR, aVL, aVF, V1, V2, V4) from 5 cardiac cycles. Results The proper P-wave dispersion in healthy dogs was determined at up to 24 ms. P-wave dispersion was statistically significant increased (p < 0.01) in dogs with chronic valvular disease and dogs with disturbances of supraventricular conduction. In dogs with the atrial enlargement the P-wave dispersion is also higher than in healthy dogs, although no significant correlation between the size of left atria and Pd was noticed (p = 0.1, r = 0,17). Conclusions The P-wave dispersion is a constant index in healthy dogs, that is why it can be used for evaluating P wave change in dogs with chronic valvular disease and in dogs with disturbances of supraventricular conduction. PMID:21396110

  9. Thrombosis of the portal vein in eleven dogs.

    PubMed

    Van Winkle, T J; Bruce, E

    1993-01-01

    Case records from the small animal necropsy service of the University of Pennsylvania (Philadelphia, PA) from January 1981 through August 1990 were searched for reports of animals with grossly visible portal vein thrombi. Eleven dogs identified from their case materials as having portal vein thrombosis were used for this study. The age of the dogs ranged from 2 to 13 years, and there were five spayed females and six males--four intact and two castrated. Seven breeds were represented (Lhasa Apso, German Wire haired Pointer, Shetland Sheepdog, Dalmatian, Irish Wolfhound, Old English Sheepdog, and Siberian Husky), and the remaining four cases were identified as mixed breeds. The weight of the dogs ranged from 7.7 to 50 kg, and most of them were considered overweight. Dogs with microthrombi and tumor emboli in the portal vein were excluded. No age, sex, or breed predisposition was found. Thrombi were also detected in the pulmonary arteries in five of the dogs and both the pulmonary arteries and aorta in one dog. The portal thrombi extended into the mesenteric veins in three dogs, resulting in infarction of the jejunum. One of these dogs and two other dogs had chronic occlusion of the portal vein, with the formation of secondary portosystemic shunts. Conditions also present in dogs with portal vein thrombi included pancreatic necrosis (four dogs), peritonitis (two dogs), distant neoplasia (three dogs), and therapy with steroids (ten dogs). PMID:8442325

  10. Physical Activity, Weight Status, and Neighborhood Characteristics of Dog Walkers

    PubMed Central

    Coleman, Karen J.; Rosenberg, Dori E.; Conway, Terry L.; Sallis, James F.; Saelens, Brian E.; Frank, Lawrence D.; Cain, Kelli

    2008-01-01

    Objective This study examined how demographics, physical activity, weight status, and neighborhood characteristics varied among households with and without dogs. Method Participants aged 20 to 65 years (N = 2199, 52% male, 75% white, Mean age = 45) were recruited from 32 neighborhoods in the Seattle, WA and Baltimore, MD regions during 2002 – 2005. Dog ownership, dog walking, education, height, weight, and family income were self-reported. Minutes of moderate to vigorous physical activity (MVPA) were measured objectively by 7-day accelerometry. Results Dog walking was associated with a higher proportion of participants who met national recommendations for MVPA (53%) when compared to those who had but did not walk their dog (33%) and to non-dog owners (46%). There were significantly fewer obese dog walkers (17%) when compared to both owners who did not walk their dogs (28%) and non-owners (22%). Dog owners who walked their dogs were more likely to live in high-walkable neighborhoods when compared to dog owners who did not walk their dogs. Conclusion Dog walking may promote physical activity and contribute to weight control. Dog walking appears to be a mechanism by which residents of high-walkable neighborhoods obtain their physical activity. PMID:18572234

  11. Acute cerebellar dysfunction with neuromuscular manifestations after scorpionism presumably caused by Tityus obscurus in Santarém, Pará / Brazil.

    PubMed

    Torrez, Pasesa P Q; Quiroga, Mariana M M; Abati, Paulo A M; Mascheretti, Melissa; Costa, Walter Silva; Campos, Luciana P; França, Francisco O S

    2015-03-01

    Scorpionism is a public health problem in many tropical countries, especially in North Africa, South India, Latin America and the Middle East. In Brazil, patients with severe scorpion envenoming have mainly cardiovascular events, including acute heart failure, acute respiratory distress syndrome and shock, death is rare. We described 58 accidents presumably caused by Tityus obscurus in Brazilian Amazonia. Patients reported a sensation of "electric shocks" which could last hours. The vast majority of patients presented a clinical picture compatible with acute cerebellar dysfunction, beginning minutes and lasting up to 2 days after the accident. They presented cerebellar ataxia, dysdiadochokinesia, dysmetry, dysarthria, dyslalia, nausea and vomiting. Besides, some patients presented myoclonus and fasciculation which can also be attributed to cerebellar dysfunction or maybe the result of direct action on skeletal muscle. Two patients had evidence of intense rhabdomyolysis and acute kidney injury. The clinical picture in this scorpion envenoming is mainly characterized by an acute dysfunction of cerebellar activities and abnormal neuromuscular manifestations and in some cases muscle injury which are not described in any other region of the world. This work presents clinical, epidemiologic, laboratory and treatment aspects of this unmatched scorpion envenoming in the state of Pará, northern Brazil. PMID:25549940

  12. Functional magnetic resonance imaging (fMRI) of attention processes in presumed obligate carriers of schizophrenia: preliminary findings

    PubMed Central

    Filbey, Francesca Mapua; Russell, Tamara; Morris, Robin G; Murray, Robin M; McDonald, Colm

    2008-01-01

    Background Presumed obligate carriers (POCs) are the first-degree relatives of people with schizophrenia who, although do not exhibit the disorder, are in direct lineage of it. Thus, this subpopulation of first-degree relatives could provide very important information with regard to the investigation of endophenotypes for schizophrenia that could clarify the often contradictory findings in schizophrenia high-risk populations. To date, despite the extant literature on schizophrenia endophenotypes, we are only aware of one other study that examined the neural mechanisms that underlie cognitive abnormalities in this group. The aim of this study was to investigate whether a more homogeneous group of relatives, such as POCs, have neural abnormalities that may be related to schizophrenia. Methods We used functional magnetic resonance imaging (fMRI) to collect blood oxygenated level dependent (BOLD) response data in six POCs and eight unrelated healthy controls while performing under conditions of sustained, selective and divided attention. Results The POCs indicated alterations in a widely distributed network of regions involved in attention processes, such as the prefrontal and temporal (including the parahippocampal gyrus) cortices, in addition to the anterior cingulate gyrus. More specifically, a general reduction in BOLD response was found in these areas compared to the healthy participants during attention processes. Conclusion These preliminary findings of decreased activity in POCs indicate that this more homogeneous population of unaffected relatives share similar neural abnormalities with people with schizophrenia, suggesting that reduced BOLD activity in the attention network may be an intermediate marker for schizophrenia. PMID:18834530

  13. WILDLIFE RESPONSES TO PEDESTRIANS AND DOGS

    Microsoft Academic Search

    Richard L. Knight

    ABSTRACT We measured the responses of two grassland passerines, one forest passerine, and one large mammal exposed to recreational treatments both on- and off-trail, including a pedestrian alone, a pedestrian accompanied by a dog-on-leash, and a dog alone. Responses measured included flush response (whether the animal flushed or not), flush distance (distance between disturbance and animal when flushed), distance of

  14. Astaxanthin uptake in domestic dogs and cats

    Microsoft Academic Search

    Jean Soon Park; Hong Wook Kim; Bridget D Mathison; Michael G Hayek; Stefan Massimino; Gregory A Reinhart; Boon P Chew

    2010-01-01

    BACKGROUND: Research on the uptake and transport of astaxanthin is lacking in most species. We studied the uptake of astaxanthin by plasma, lipoproteins and leukocytes in domestic dogs and cats. METHODS: Mature female Beagle dogs (18 to 19 mo old; 11 to 14 kg BW) were dosed orally with 0, 0.1, 0.5, 2.5, 10 or 40 mg astaxanthin and blood

  15. Photosensitive dermatitis in two Collie working dogs

    Microsoft Academic Search

    R. A. Fairley

    1982-01-01

    Two Collie working dogs were examined because of the sudden appearance of a skin condition. Both dogs were depressed and anorectic with an acute exudative dermatitis confined to areas of non-pigmented skin. Antibacterial treatment was instituted initially followed by long-term use of a sun-protective cream.A diagnosis of photosensitive dermatitis was made but the cause of the photosensitivity was not determined.

  16. Portal vein aneurysm in a dog.

    PubMed

    Miyawaki, Shingo; Washizu, Makoto; Maeda, Sadatoshi; Shibata, Sanae; Watanabe, Kazuhiro; Yamazoe, Kazuaki

    2012-09-01

    Portal vein aneurysm (PVA) is a rare abnormal dilatation of the portal vein, which has not been reported in dogs. We describe the findings of ultrasound and computed tomography in a case of PVA in a young male toy poodle, with the final diagnosis established by explorative surgical observation. The dog had an aneurysmal fusiform dilatation in the extrahepatic portal vein with portal hypertension and multiple portsystemic shunts. This is the first report of canine PVA. PMID:22571895

  17. A dog rabies vaccination campaign in rural Africa: impact on the incidence of dog rabies and human dog-bite injuries

    Microsoft Academic Search

    S Cleaveland; M Kaare; P Tiringa; T Mlengeya; J Barrat

    2003-01-01

    Despite the availability of safe and effective rabies vaccines, the incidence of dog rabies has been increasing throughout much of sub-Saharan Africa. Here we describe a vaccination strategy that has resulted in successful control of rabies in a rural dog population of Northwestern Tanzania. From October 1996 to February 2001, four central-point dog vaccination campaigns were conducted in villages within

  18. Suppression of fertility in adult dogs.

    PubMed

    Maenhoudt, C; Santos, N R; Fontbonne, A

    2014-06-01

    Unfortunately, the overpopulation of dogs is still a problem in the majority of countries and even though surgical methods of sterilization, the most traditional and commonly used technique, have been intensively performed, the impact on the dog population is negligible. The neutering of companion animals as ovariohysterectomy (spaying) or orchidectomy (castration) has its limitations because of the cost, the need of a surgical environment and the risk of surgical and/or anaesthetical complications (ACCD 2009). In fact, surgical castration has been banished in some northern European countries and has limited acceptance in other countries. In a survey performed in Sao Paulo, Brazil, 56.5% of the owners of adopted shelter dogs were against the surgical procedure for different reasons (Soto et al. 2005). Currently, the options for contraception, defined as suppression of fertility are based on hormonal treatment. The treatments can be divided into analogues of gonadotropin releasing hormone (GnRH), progestins and androgens. Other possibilities of contraception are via the immunological system with vaccinations against GnRH, the luteinizing hormone (LH) receptor and the zona pellucida proteins. Finally, there is also the intra-epididymal or intratesticular injection of sclerosing substances in dogs. Mechanical devices to disrupt fertility are not used anymore due to the side effects. Suppression of fertility in adult dogs will be reviewed in order of use and possible impact on the dog population. PMID:24947862

  19. Experimental canine parvovirus infection in dogs.

    PubMed

    Pollock, R V

    1982-04-01

    In specific pathogen-free dogs, clinical signs of experimental canine parvovirus infection were mild, inconsistent and transient. Clinical signs were more pronounced in conventionally-raised dogs, but the severe disease reported in field cases was not reproduced in either group. A pronounced plasma viremia occurred on the 2nd to 4th day post-infection (d.p.i.) in dogs challenged oronasally. Antibody was detectable on the 5th d.p.i. Marked pyrexia was rare, but a significant temperature rise usually coincided with the appearance of antibody and the cessation of viremia. Significant lymphopenia, but not leukopenia, occurred on the 3rd to 7th d.p.i. Virus could be readily isolated from fecal matter on the 3rd to 8th d.p.i.; a few dogs continued to shed virus for up to 12 days. In dogs challenged parenterally, the onset of elevated temperatures, viral shed and antibody production occurred 24-48 hours sooner. Convalescent dogs were no longer contagious for susceptible contact animals 25 days or longer after challenge, although infectious virus persisted in feces for more than 6 months at room temperature. Active giardiasis seemed to exacerbate the clinical syndrome, although treatment with corticosteroids or anti-thymocyte serum did not. PMID:6211333

  20. Efficacy of Malarone® in Dogs Naturally Infected with Babesia gibsoni

    PubMed Central

    IGUCHI, Aiko; SHIRANAGA, Nobuyuki; MATSUU, Aya; HIKASA, Yoshiaki

    2014-01-01

    ABSTRACT The efficacy of Malarone® alone and in combination with doxycycline (DOXY) against Babesia gibsoni infections was examined in 8 dogs. In all dogs except one treated with Malarone®, parasitemia decreased, and anemia improved soon after initiation of treatment. However, 3 of 4 dogs treated with Malarone® relapsed, and relapse was inhibited in 2 of 4 dogs treated with Malarone® and DOXY. All relapsed dogs responded well to the second treatment, but 1 dog relapsed again and did not respond to the third treatment. Malarone® may be useful for acute stage of B. gibsoni infections, and at least second repeating treatment might be effective. PMID:24909969

  1. Concomitant occurrence of Campylobacter and parvoviruses in dogs with gastroenteritis.

    PubMed

    Sandstedt, K; Wierup, M

    1981-04-01

    In 1979 a canine parvovirus infection was widespread among dogs in Sweden. During the epizootic faecal samples were taken for bacteriological examination from 77 hospitalised dogs at an animal clinic. Forty-nine of the dogs had signs of gastroenteritis and they were all infected with canine parvovirus according to serological investigations. The remaining 28 dogs were referred to the clinic for other reasons. Campylobacter was isolated from 23 out of the 49 dogs with gastroenteritis and from 4 out of 28 dogs lacking symptoms of enteritis. The significance of these findings is discussed. PMID:7342413

  2. The Role of Pet Dogs in Casual Conversations of Elderly Adults

    Microsoft Academic Search

    John Rogers; Lynette A. Hart; Ronald P. Boltz

    1993-01-01

    Casual conversations were recorded as elderly persons routinely walked their dogs through a familiar mobile home park in the United States. Control observations included walks without dogs by owners and non-owners of dogs. All owners talked to and about their dogs. Transcribed conversations indicated that dogs were a primary focus of conversation. A majority of sentences to dogs were imperatives;

  3. Contact with Domestic Dogs Increases Pathogen Exposure in Endangered African Wild Dogs (Lycaon pictus)

    PubMed Central

    Woodroffe, Rosie; Prager, Katherine C.; Conrad, Patricia A.; Dubovi, Edward J.; Mazet, Jonna A. K.

    2012-01-01

    Background Infectious diseases have contributed to the decline and local extinction of several wildlife species, including African wild dogs (Lycaon pictus). Mitigating such disease threats is challenging, partly because uncertainty about disease dynamics makes it difficult to identify the best management approaches. Serious impacts on susceptible populations most frequently occur when generalist pathogens are maintained within populations of abundant (often domestic) “reservoir” hosts, and spill over into less abundant host species. If this is the case, disease control directed at the reservoir host might be most appropriate. However, pathogen transmission within threatened host populations may also be important, and may not be controllable by managing another host species. Methodology/Principal Findings We investigated interspecific and intraspecific transmission routes, by comparing African wild dogs' exposure to six canine pathogens with behavioural measures of their opportunities for contact with domestic dogs and with other wild dogs. Domestic dog contact was associated with exposure to canine parvovirus, Ehrlichia canis, Neospora caninum and perhaps rabies virus, but not with exposure to canine distemper virus or canine coronavirus. Contact with other wild dogs appeared not to increase the risk of exposure to any of the pathogens. Conclusions/Significance These findings, combined with other data, suggest that management directed at domestic dogs might help to protect wild dog populations from rabies virus, but not from canine distemper virus. However, further analyses are needed to determine the management approaches – including no intervention – which are most appropriate for each pathogen. PMID:22238695

  4. How to prevent dog bite injuries? Children misinterpret dogs facial expressions

    Microsoft Academic Search

    K Meints; A Racca; N Hickey

    2010-01-01

    Almost half of school children reported that they were bitten (Beck & Jones,1985; Spiegel, 2000) and in other research, 20% of dog-owning parents reported their child bitten (Wilson, Dwyer and Bennett, 2003, see also Lakestani, Donaldson, Verga & Waran, 2006). Child-initiated interactions with the dog trigger up to 86 % of injuries at home. Recently, it was found that young

  5. Dog Experts' Brains Distinguish Socially Relevant Body Postures Similarly in Dogs and Humans

    Microsoft Academic Search

    Miiamaaria V. Kujala; Jan Kujala; Synnöve Carlson; Riitta Hari

    2012-01-01

    We read conspecifics' social cues effortlessly, but little is known about our abilities to understand social gestures of other species. To investigate the neural underpinnings of such skills, we used functional magnetic resonance imaging to study the brain activity of experts and non-experts of dog behavior while they observed humans or dogs either interacting with, or facing away from a

  6. Human perception of fear in dogs varies according to experience with dogs.

    PubMed

    Wan, Michele; Bolger, Niall; Champagne, Frances A

    2012-01-01

    To investigate the role of experience in humans' perception of emotion using canine visual signals, we asked adults with various levels of dog experience to interpret the emotions of dogs displayed in videos. The video stimuli had been pre-categorized by an expert panel of dog behavior professionals as showing examples of happy or fearful dog behavior. In a sample of 2,163 participants, the level of dog experience strongly predicted identification of fearful, but not of happy, emotional examples. The probability of selecting the "fearful" category to describe fearful examples increased with experience and ranged from.30 among those who had never lived with a dog to greater than.70 among dog professionals. In contrast, the probability of selecting the "happy" category to describe happy emotional examples varied little by experience, ranging from.90 to.93. In addition, the number of physical features of the dog that participants reported using for emotional interpretations increased with experience, and in particular, more-experienced respondents were more likely to attend to the ears. Lastly, more-experienced respondents provided lower difficulty and higher accuracy self-ratings than less-experienced respondents when interpreting both happy and fearful emotional examples. The human perception of emotion in other humans has previously been shown to be sensitive to individual differences in social experience, and the results of the current study extend the notion of experience-dependent processes from the intraspecific to the interspecific domain. PMID:23284765

  7. Serological Discrimination of Dogs Infected with Gastric Helicobacter spp. and Uninfected Dogs

    Microsoft Academic Search

    DALIT STRAUSS-AYALI; KENNETH W. SIMPSON; AMY H. SCHEIN; PATRICK L. MCDONOUGH; RICHARD H. JACOBSON; BETH A. VALENTINE; JEFF PEACOCK

    1999-01-01

    Characterization of the humoral immune responses of people to Helicobacter pylori infection has facilitated the investigation of the host response to bacterial virulence factors and the development of sensitive and specific diagnostic tests. Dogs are commonly infected with gastric Helicobacter spp., but the presence of multiple Helicobacter spp. and possible coinfection in individual dogs have complicated serological evaluation. Evalu- ation

  8. Short-term synchrony in diverse motor nuclei presumed to receive different extents of direct cortical input

    PubMed Central

    Keen, Douglas A.; Chou, Li-Wei; Nordstrom, Michael A.

    2012-01-01

    Motor units within human muscles usually exhibit a significant degree of short-term synchronization. Such coincident spiking typically has been attributed to last-order projections that provide common synaptic input across motor neurons. The extent of branched input arising directly from cortical neurons has often been suggested as a critical factor determining the magnitude of short-term synchrony. The purpose of this study, therefore, was to quantify motor unit synchrony in a variety of human muscles differing in the presumed extent of cortical input to their respective motor nuclei. Cross-correlation histograms were generated from the firing times of 551 pairs of motor units in 16 human muscles. Motor unit synchrony tended to be weakest for proximal muscles and strongest for more distal muscles. Previous work in monkeys and humans has shown that the strength of cortical inputs to motor neurons also exhibits a similar proximal-to-distal gradient. However, in the present study, proximal-distal location was not an exclusive predictor of synchrony magnitude. The muscle that exhibited the least synchrony was an elbow flexor, whereas the greatest synchrony was most often found in intrinsic foot muscles. Furthermore, the strength of corticospinal inputs to the abductor hallucis muscle, an intrinsic foot muscle, as assessed through transcranial magnetic stimulation, was weaker than that projecting to the tibialis anterior muscle, even though the abductor hallucis muscle had higher synchrony values compared with the tibialis anterior muscle. We argue, therefore, that factors other than the potency of cortical inputs to motor neurons, such as the number of motor neurons innervating a muscle, significantly affects motor unit synchrony. PMID:23019009

  9. Characteristics of persons with overactive bladder of presumed neurologic origin: Results from the Boston Area Community Health (BACH) Survey

    PubMed Central

    Hall, Susan A.; Curto, Teresa M.; Onyenwenyi, Ahunna; Lemack, Gary E.; Tennstedt, Sharon L.; Link, Carol L.; McKinlay, John B.

    2012-01-01

    Aims To compare the descriptive epidemiology of overactive bladder (OAB) of presumed neurologic origin (NOAB) to OAB of non-neurologic origin (N-NOAB). Methods 5,503 community-dwelling persons aged 30-79 were interviewed regarding urologic symptoms (2002-2005). NOAB was defined as symptoms of urgency and/or urgency incontinence among those with a self-reported history of health care provider diagnosed stroke (N=98), multiple sclerosis (N=21), or Parkinson’s disease (N=7). N-NOAB was defined identically but occurring among those not reporting neurologic disease (ND). Prevalence estimates were weighted to reflect sampling design; chi-square, Fisher’s exact, or t-tests were used to test differences. Urologic symptom interference was assessed using the Epstein scale, while the impact of urinary incontinence (UI) on health-related quality-of-life (HRQOL) was measured using a modification of the Incontinence Impact Questionnaire-7. Results 45 (31.0%) of 125 persons with ND and 994 (16.7%) of 5378 persons without ND reported OAB symptoms. The overall prevalence of NOAB and N-NOAB was 0.6% and 16.4%, respectively. Persons with NOAB had higher (worse) mean American Urologic Association Symptom Index scores (13.0 vs. 10.0, p=0.09) compared to those with N-NOAB, and were significantly more likely to have diabetes, high blood pressure, cardiac disease and fair/poor self-reported health (all p<0.05). Mean symptom interference and UI HRQOL scores were significantly higher (worse) in the NOAB group compared to persons with N-NOAB (all p<0.05). Conclusions Persons with NOAB appeared to have a greater burden of urologic illness with respect to symptom interference and HRQOL compared to persons with N-NOAB. PMID:22674347

  10. Analysis of Pediatric Facial Dog Bites

    PubMed Central

    Chen, Henry H.; Neumeier, Anna T.; Davies, Brett W.; Durairaj, Vikram D.

    2013-01-01

    The aim of this study was to characterize and report the epidemiological data regarding pediatric facial dog bites. For this study, a retrospective chart review was used. This study was performed at a large tertiary pediatric hospital. All children younger than 18 years who sought medical attention after a facial dog bite between January 1, 2003, and December 31, 2008, were included. Demographic and epidemiologic data were collected and analyzed. A total of 537 children were identified. The average age was 4.59?±?3.36 years, with a slight male preponderance (52.0%). The majority of dog bites occurred in children 5 years of age or younger (68.0%). Almost all (89.8%) of the dogs were known to the children. When circumstances surrounding the bite were documented, over half (53.2%) of the cases were provoked. The most common breeds were mixed breed (23.0%), Labrador retriever (13.7%), Rottweiler (4.9%), and German shepherd (4.4%). Inpatient treatment was required in 121 (22.5%) patients with an average length of stay of 2.96?±?2.77 days. Children 5 years or younger were more likely to be hospitalized than older children. Children 5 years old and younger are at high risk for being bitten in the face by a familiar dog and are more likely to require hospitalization than older children. Certain dog breeds are more likely to bite, and there is often a history of provocation. There is a tremendous financial and psychosocial burden associated with dog bites, and prevention strategies should focus on education with the aid of public policies and better documentation and reporting systems. PMID:24436765

  11. Completeness of the dog registry and estimation of the dog population size in a densely populated area of Rome.

    PubMed

    Caminiti, Antonino; Sala, Marcello; Panetta, Valentina; Battisti, Sabrina; Meoli, Roberta; Rombolŕ, Pasquale; Spallucci, Valentina; Eleni, Claudia; Scaramozzino, Paola

    2014-01-01

    In most European countries, registration and identification of dogs is compulsory. In Italy, the national dog registry is composed of regional dog registries. Although dog registries have been established for many years, the issue related to completeness of data has not been addressed so far. The objective of this study was twofold: first to assess the completeness of data of the dog registry through telephone interview of a sample of dog owners drawn from the dog registry, then to estimate the total owned dog population in 4 boroughs of Rome. For the second objective, a capture-recapture method was applied using data from the dog registry and data from a face-to-face questionnaire submitted to people waiting in the sitting room of 5 points of access for booking and payment of primary and specialist care. Different scenarios are proposed to verify the assumptions of the estimation procedure and potential biases are discussed. The completeness of data of the dog registry was 88.9% (95% CI: 85.8-91.9%) and the owned-dog population was estimated at 26,244 dogs (95% CI: 24,110-28,383). The dog registry is an important source of information especially when it is properly updated and completeness of data is known. PMID:24188820

  12. Do dogs (Canis familiaris) seek help in an emergency?

    PubMed

    Macpherson, Krista; Roberts, William A

    2006-05-01

    The question of whether dogs recognize an emergency and understand the need to seek help from a bystander was tested in two experiments. In the first experiment, dogs' owners feigned a heart attack in an open field, and in the second experiment, dogs' owners experienced an accident in which a bookcase fell on them and pinned them to the floor. In these experiments, one or two bystanders were available to which dogs could go for help. The dogs' behavior was taped for 6 min after the owner had fallen and was later scored for the frequency and time the dogs spent performing different behaviors. In no case did a dog solicit help from a bystander. It is concluded that dogs did not understand the nature of the emergency or the need to obtain help. PMID:16719589

  13. Contributed Paper Effectiveness of Scat-Detection Dogs in Determining

    E-print Network

    Wasser, Samuel

    Contributed Paper Effectiveness of Scat-Detection Dogs in Determining Species Presence of scat-detection dogs in detecting presence of five species of mammals threatened with extinction anteater (Myrmecophaga tridactyla), and giant armadillo (Priodontes maximus). The probability of scat

  14. New Research May Help Control Brown Dog Ticks

    MedlinePLUS

    ... 152810.html New Research May Help Control Brown Dog Ticks These pests breed indoors and may be ... to more effective ways to control the brown dog tick, a species that can cause major problems ...

  15. A Study of Dog Bites and their Prevention 

    E-print Network

    Lakestani, Nelly N

    2007-01-01

    Previous studies have suggested that children are more at risk of suffering from serious dog bite injuries than adults. In order to generate an overview of characteristics of dog bite victims in Europe, different ...

  16. Bounding on Rough Terrain with the LittleDog Robot

    E-print Network

    Shkolnik, Alexander C.

    A motion planning algorithm is described for bounding over rough terrain with the LittleDog robot. Unlike walking gaits, bounding is highly dynamic and cannot be planned with quasi-steady approximations. LittleDog is modeled ...

  17. Vaccinate Puppies Against Parvovirus Before They Meet Other Dogs

    MedlinePLUS

    ... Vaccinate Puppies Against Parvovirus Before They Meet Other Dogs Highly contagious virus can cause serious illness, even ... fully vaccinated against parvovirus before going to the dog park or anywhere else your pup might encounter ...

  18. MyDogDNA is a simple and easy-to-use testing service that helps you understand your dog's health and increase

    E-print Network

    Lacy, Bob

    MyDogDNA is a simple and easy-to-use testing service that helps you understand your dog's health: Password: Home MyDogDNA Pass Breeds How It Works News Puppy Search Engine Contact us MyDogDNA news Exploring dog DNA testing, breed health and discoveries in canine genetics Authors Languages Deutsch

  19. Will breed-specific legislation reduce dog bites?

    PubMed Central

    Bandow, J H

    1996-01-01

    So how do we deal with biting dogs? To start with, we must remind ourselves that biting is a natural activity of all dogs, and that there is potential for injury. All dog owners must understand this and must be made aware that they are fully responsible for the actions of their dogs. I am not convinced that this is universally understood by dog owners, nor am I satisfied that every dog owner takes the necessary steps to train and socialize their dog. Owners need to be encouraged to actively work at inhibiting biting behaviour when dogs are young. As well, all dogs should be socialized to accept children, regardless of whether or not there are children living with the dog. Adults without dogs need to learn that dogs don't understand "people's rights," and that dogs should not be expected to act differently with different people. Adults also need to understand that young children should never be left alone with a dog (or a cat) without supervision, and that all children should be taught how to behave around dogs, particulary around dogs they don't know. So long as we have dogs living with us there will be people who get bitten. The most effective way to prevent bites is to encourage dog owners to become knowledgeable about their animals and to train and socialize them so that they can become good dog neighbours. Many municipalities already have by-laws that deal with animal bites, and in Ontario the Dog Owners Liability Act has proven to be effective in confining, restraining or disposing of biting or attacking dogs judged to be a definite threat to public health and safety, and when evidence warrants, there is always Section #221 of the Criminal Code of Canada. Most legislation deals with bites after the fact. If we want to prevent all bites, there is only one sure way and that is to ban all dogs. That is of course as unrealistic as trying to prevent bites by enacting breed specific legislation. PMID:8853880

  20. Neospora caninum prevalence in dogs raised under different living conditions.

    PubMed

    Nazir, Muhammad Mudasser; Maqbool, Azhar; Akhtar, Masood; Ayaz, Mazhar; Ahmad, Atif Nisar; Ashraf, Kamran; Ali, Asif; Alam, Muhammad Azhar; Ali, Muhammad Amjad; Khalid, Abdur Rauf; Lindsay, David S

    2014-08-29

    Neospora caninum is an important cause of abortion in dairy cattle worldwide. Dogs are important in the epidemiology of N. caninum because they act as definitive hosts shedding oocysts in the environment. Vertical transmission of the parasite is well recognized as an important aspect of the epidemiology of the parasite but the importance of horizontal transmission has been less studied. A N. caninum competitive ELISA was used to examine serum samples from 600 dogs that were raised under 4 different living conditions. Samples from 138 dogs living on 24 dairies with a prevalence (0-70%) of anti-N. caninum antibodies in the cattle, 294 pet dogs without neurological signs, 76 from pet dogs exhibiting neurological signs, and 92 stray dogs were examined. The overall seroprevalence of N. caninum was 23.5% (95% CI = ± 2.99) in the 600 dogs. Significant (P < 0.05) differences were observed between the 4 different populations of dogs. The number of N. caninum positive samples were: 51 (36.9%, 95% CI = ± 3.09) of 138 dogs from dairies, 31 (10.5%, 95% CI = ± 6.38) of 294 pet dogs without neurological signs, disorders, 22 (28.9%, 95% CI = ± 6.70) of 76 pet dogs with neurological signs, and 37 (40.2%, 95% CI = ± 2.83) of 92 stray dogs. Seropositivity to N. caninum in dogs from dairies was associated with a high prevalence of N. caninum antibodies in the cattle. At the 3 dairies where no dogs were present, the seroprevalence to N. caninum in the cattle was significantly lower (P < 0.05) than in the 21 dairies where dogs were present. Seroprevalence was significantly higher (P < 0.05) in male dogs (97 of 366; 26.5%, 95% CI = ± 3.40) than in female dogs (44 of 234; 18.8%, 95% CI = ± 5.65). Seroprevalence in dogs increased with age suggesting postnatal exposure to N. caninum infection however, this increase was not significant (P > 0.05). The prevalence of N. caninum antibodies was not significantly (P>0.05) different in dogs based on breed. These findings suggest a relationship between N. caninum infection of dogs from dairies and cattle on these dairies. However, further research is required to determine what is the most important way dogs acquire infection and how to prevent dogs from shedding oocysts. PMID:24957000

  1. Outcomes of Dogs Presented for Cataract Evaluation: A Retrospective Study

    Microsoft Academic Search

    EA Hendrix; Diane Hendrix

    2005-01-01

    Two hundred and forty-four dogs were evaluated for cataracts at the University of Tennessee from January 2001 to December 2002. Fifty-four canine breeds were affected. Odds ratios for cataracts were significantly higher for six purebred dogs (including the cocker spaniel, miniature schnauzer, toy poodle, Boston terrier, miniature poodle, and bichon frise) compared with mixed-breed dogs. One hundred fifty-nine dogs did

  2. Nutrition, care, and behavior of captive prairie dogs.

    PubMed

    Hoogland, John L; James, Dianne A; Watson, Lynda

    2009-05-01

    Prairie dogs are burrowing mammals that inhabit the grasslands of western North America. This article discusses the black-tailed prairie dog, the most common species and the one most likely to be found in zoos and private homes. The authors discuss several topics related to having prairie dogs as pets, such as why they make good pets, types of housing, diet, diseases, and injuries. The article concludes with information about where to obtain prairie dogs as pets. PMID:19341952

  3. Dogs can discriminate human smiling faces from blank expressions

    Microsoft Academic Search

    Miho Nagasawa; Kensuke Murai; Kazutaka Mogi; Takefumi Kikusui

    2011-01-01

    Dogs have a unique ability to understand visual cues from humans. We investigated whether dogs can discriminate between human\\u000a facial expressions. Photographs of human faces were used to test nine pet dogs in two-choice discrimination tasks. The training\\u000a phases involved each dog learning to discriminate between a set of photographs of their owner’s smiling and blank face. Of\\u000a the nine

  4. Histidine, an Essential Amino Acid for Adult Dogs1

    Microsoft Academic Search

    BRUNO CIANCIARUSO; MICHAEL R. JONES; JOEL D. KOPPLE

    Twenty-seven adult female mongrel dogs were studied to eval uate whether histidine is an essential amino acid. Dogs were tube-fed isocaloric, isonitrogenous amino acid diets which provided either no histidine or 67 mg histidine\\/kg body weight\\/day. The histidine-free diet was fed to 10 dogs for 5.6 ± 3.6 (so) days and to six dogs for 59.2 ± 6.0 days. In

  5. Original article Chiral inversion of fenoprofen in horses and dogs

    E-print Network

    Paris-Sud XI, Université de

    Original article Chiral inversion of fenoprofen in horses and dogs: an in vivo-in vitro study geldings and three male beagle dogs, following intravenous doses of racemic FPF (1 mg/kg in horses), R(-)FPF (0.5 mg/kg in horses, 1 mg/kg in dogs), and S(+)FPF (0.5 mg/kg in horses, 1 mg/kg in dogs

  6. Nitrogen-sparing effect of lipid emulsion in septic dogs

    Microsoft Academic Search

    Keiji Iriyama; Hiroshi Nishiwaki; Noriko Kusaka; Tadashi Teranishi; Hiroshi Mori; Hiroshi Suzuki

    1985-01-01

    Effects of intavenously administered lipid emulsion on the nitrogen balance in dogs with intraabdominal infection were investigated.\\u000a The nitrogen balance in dogs supported by parenteral nutrition (PN) with glucose alone was superior to that in dogs supported\\u000a by PN with glucose and lipid emulsion, in the absence of intraabdominal infection. On the other hand, the nitrogen balance\\u000a in dogs supported

  7. Congenital cardiac disease in dogs.

    PubMed

    Aronson, E; McCaw, D

    1984-09-01

    Aortic stenosis is a heritable cardiac anomaly most common in German Shepherds, Boxers and Newfoundlands, and less common in Pugs, English Bulldogs, Boston Terriers, Fox Terriers, Schnauzers and Bassets. Clinical signs are associated with secondary left-sided heart failure and include coughing, moist rales, exercise intolerance, arrhythmias and a weak femoral pulse. It causes an ejection-type crescendo-decrescendo, systolic murmur best heard on the left side near the elbow. The ECG may be normal or may show signs of left ventricular hypertrophy, including an axis of less than 40 degrees, a QRS complex of greater than 60 seconds in duration, R waves greater than 3 mv in amplitude, ST segment slurring or depression, or T waves of an amplitude greater than 25% of that of R waves. A LAT radiograph usually reveals an enlarged cardiac silhouette, loss of the cranial cardiac waist, and normal pulmonary vasculature, while DV projections show an elongated cardiac silhouette, rounding of the left ventricular border, and a normal descending aorta. Nonselective angiocardiography reveals poststenotic dilatation of the aorta. Treatment of severely affected dogs involves surgical correction. PMID:6482869

  8. Toxicity of hydroxyurea in rats and dogs.

    PubMed

    Morton, Daniel; Reed, Lori; Huang, Wenhu; Marcek, John M; Austin-LaFrance, Robert; Northcott, Carrie A; Schelling, Scott H; Enerson, Bradley E; Tomlinson, Lindsay

    2015-06-01

    The toxicity of hydroxyurea, a treatment for specific neoplasms, sickle-cell disease, polycythemia, and thrombocytosis that kills cells in mitosis, was assessed in repeat-dose, oral gavage studies in rats and dogs and a cardiovascular study in telemetered dogs. Hydroxyurea produced hematopoietic, lymphoid, cardiovascular, and gastrointestinal toxicity with steep dose response curves. In rats dosed for 10 days, 50 mg/kg/day was tolerated; 500 mg/kg/day produced decreased body weight gain; decreased circulating leukocytes, erythrocytes, and platelets; decreased cellularity of thymus, lymph nodes, and bone marrow; and epithelial degeneration and/or dysplasia of the stomach and small intestine; 1,500 mg/kg/day resulted in deaths on day 5. In dogs, a single dose at ?250 mg/kg caused prostration leading to unscheduled euthanasia. Dogs administered 50 mg/kg/day for 1 month had decreased circulating leukocytes, erythrocytes, and platelets; increased bone marrow cellularity with decreased maturing granulocytes; increased creatinine kinase activity; and increased iron pigment in bone marrow and hepatic sinusoidal cells. In telemetered dogs, doses ?15 mg/kg decreased systolic blood pressure (BP); 50 mg/kg increased diastolic BP, heart rate, and change in blood pressure over time (+dP/dt), and decreased QT and PR intervals and maximum left ventricular systolic and end diastolic pressures with measures returning to control levels within 24 hr. PMID:25391310

  9. Oxytocin promotes social bonding in dogs

    PubMed Central

    Romero, Teresa; Nagasawa, Miho; Mogi, Kazutaka; Hasegawa, Toshikazu; Kikusui, Takefumi

    2014-01-01

    Recent evidence suggests that enduring social bonds have fitness benefits. However, very little is known about the neural circuitry and neurochemistry underlying the formation and maintenance of stable social bonds outside reproductive contexts. Oxytocin (OT), a neuropeptide synthetized by the hypothalamus in mammals, regulates many complex forms of social behavior and cognition in both human and nonhuman animals. Animal research, however, has concentrated on monogamous mammals, and it remains unknown whether OT also modulates social bonds in nonreproductive contexts. In this study we provide behavioral evidence that exogenous OT promotes positive social behaviors in the domestic dog toward not only conspecifics but also human partners. Specifically, when sprayed with OT, dogs showed higher social orientation and affiliation toward their owners and higher affiliation and approach behaviors toward dog partners than when sprayed with placebo. Additionally, the exchange of socio-positive behaviors with dog partners triggered the release of endogenous OT, highlighting the involvement of OT in the development of social relationships in the domestic dog. These data provide new insight into the mechanisms that facilitate the maintenance of close social bonds beyond immediate reproductive interest or genetic ties and complement a growing body of evidence that identifies OT as one of the neurochemical foundations of sociality in mammalian species. PMID:24927552

  10. Pseudorabies virus infection in Oklahoma hunting dogs.

    PubMed

    Cramer, Sarah D; Campbell, Gregory A; Njaa, Bradley L; Morgan, Sandra E; Smith, Stephen K; McLin, William R; Brodersen, Bruce W; Wise, Annabel G; Scherba, Gail; Langohr, Ingeborg M; Maes, Roger K

    2011-09-01

    Pseudorabies is caused by Suid herpesvirus 1, a member of the Alphaherpesvirinae subfamily. Although pigs are the natural host of Pseudorabies virus (PRV), the virus has a broad host range and may cause fatal encephalitis in many species. The United States obtained PRV-free status in 2004 after the virus was eradicated from domestic swineherds, but the virus is still present in feral swine populations. The current report describes PRV infection in 3 dogs that were used to hunt feral swine. The dogs developed clinical signs including facial pruritus with facial abrasions, dyspnea, vomiting, diarrhea, ataxia, muscle stiffness, and death. Two were euthanized, and 1 died within approximately 48 hr after onset of clinical signs. The salient histologic changes consisted of neutrophilic trigeminal ganglioneuritis with neuronophagia and equivocal intranuclear inclusion bodies. Pseudorabies virus was isolated from fresh tissues from 2 of the dogs, and immunohistochemistry detected the virus in the third dog. Virus sequencing and phylogeny, based upon available GenBank sequences, revealed that the virus was likely a field strain that was closely related to a cluster of PRV strains previously identified in Illinois. Though eradicated from domestic swine in the United States, PRV is present in populations of feral swine, and should therefore continue to be considered a possible cause of disease in dogs and other domestic animals with compatible clinical history and signs. Continued surveillance is necessary to prevent reintroduction of PRV into domestic swine. PMID:21908347

  11. Heartworm in dogs in Canada in 1989

    PubMed Central

    Slocombe, J. Owen D.

    1990-01-01

    In late November 1989, 1732 clinics and institutional veterinarians were sent a questionnaire to assess the status of Dirofilaria immitis, and 51.7% responded. Of 247,716 dogs tested, 394 had D. immitis microfilariae and 51 were amicrofilaremic for a total of 445 cases and heartworm prevalence of 0.17%. Most (408) of these dogs had no preventive medication and the prevalence among dogs tested and unprotected was 1.01%. That prevalence was considerably higher in endemic areas. Thirty-seven dogs with heartworm had preventive medication. Heartworm was most frequent in companion dogs over three years of age maintained outdoors in rural areas. About 75% of the cases had never left Canada, 26% had clinical signs and 125 were not treated. Heartworm was reported from British Columbia, Manitoba, Ontario, Quebec, Nova Scotia and Newfoundland, but 383 cases were in Ontario. South-western Ontario was the primary focus of infection. There were 33 cases in Quebec and 24 in Manitoba, mainly found in and around Metropolitan Montreal and Winnipeg respectively. PMID:17423627

  12. Mutagenicity of the halogenated olefin, 2-bromo-2-chloro-1,1-difluoroethylene, a presumed metabolite of the inhalation anesthetic halothane.

    PubMed

    Garro, A J; Phillips, R A

    1977-12-01

    The presumed halothane metabolite, 2-bromo-1,1-difluoroethylene, produces both base substitution and frameshift mutations in Salmonella typhimurium. Direct mutagenesis of isolated DNA also was observed by using a Bacillus subtils transformation assay to score the production of mutagenic lesions in transforming DNA. PMID:417917

  13. Even Lesbian Youths or Those Presumed to Be Lesbians Are Protected by the Constitution of Uganda--But to a Limited Extent: Rules the High Court

    ERIC Educational Resources Information Center

    Mujuzi, Jamil Ddamulira

    2009-01-01

    The Ugandan Penal Code criminalizes same-sex relationships. The author analyzes the Ugandan High Court decision where the judge relied on the Constitution and international human rights instruments to hold that law enforcement officers must respect the rights to privacy and human dignity even of those people presumed to be in same-sex…

  14. Explosives detection by sniffer dogs following strenuous physical activity

    Microsoft Academic Search

    Irit Gazit; Joseph Terkel

    2003-01-01

    Reduced olfactory efficiency in sniffer dogs results mainly from overheating, and causes physiological and behavioural resources to be diverted from concentration on the assigned task and applied instead to methods of body cooling. Dogs do not possess sweat glands, and panting is the main means of cooling the body. Since a dog can either sniff or pant, but can never

  15. Distribution and conservation of African wild dogs in Cameroon

    Microsoft Academic Search

    Thomas Breuer

    The African wild dog (Lycaon pictus) has de- clined dramatically during the last century and has experienced a significant reduction in its range throughout sub-Saharan Africa. Very little is known about wild dogs in Central Af- rica, especially the population in northern Cameroon. Human and ecological factors lim- iting wild dogs in and around Faro National Park were investigated in

  16. The Cost Efficiency of Wild Dog Conservation in South Africa

    Microsoft Academic Search

    P. A. LINDSEY; R. ALEXANDER; J. T. DU TOIT; M. G. L. MILLS

    2005-01-01

    Aside from Kruger National Park, no other suitable reserves of sufficient size exist in South Africa that will hold a viable population of wild dogs (Lycaon pictus). Consequently, conservation efforts have been focused on creating a metapopulation through a series of wild dog reintroductions into isolated fenced reserves. Additional potential exists for conserving wild dogs on private ranch land. Establishing

  17. O1 Dog Pack revising mental models creating mental models

    E-print Network

    Packard, Jane M.

    , or at a dog park). Observe the first video clip and write general notes on what happened in the box providedO1 Dog Pack revising mental models creating mental models A1 First sources Q1 Folk Psychology Wolf Inquiry Activity Module 1. Dogs & People Partnerships ANSWER QUESTIONS Distinguish between

  18. Squamous cell carcinoma of the nasal planum in 17 dogs

    Microsoft Academic Search

    B. D. X. Lascelles; A. T. Parry; M. F. Stidworthy; J. M. Dobson; R. A. S. White

    2000-01-01

    Squamous cell carcinoma of the nasal planum was diagnosed in 17 dogs over a period of 11 years. Ulceration, bleeding and sneezing were the most common clinical signs. One dog had cytological evidence of metastasis to the local lymph node. The dogs were treated by surgical resection, fractionated megavoltage irradiation, or a combination of the two. Surgical resection gave the

  19. 9 CFR 3.8 - Exercise for dogs.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ...2013-01-01 2013-01-01 false Exercise for dogs. 3.8 Section 3.8 ...Health and Husbandry Standards § 3.8 Exercise for dogs. Dealers, exhibitors...provide dogs with the opportunity for exercise. In addition, the plan must be...

  20. 9 CFR 3.8 - Exercise for dogs.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ...2011-01-01 2011-01-01 false Exercise for dogs. 3.8 Section 3.8 ...Health and Husbandry Standards § 3.8 Exercise for dogs. Dealers, exhibitors...provide dogs with the opportunity for exercise. In addition, the plan must be...

  1. 9 CFR 3.8 - Exercise for dogs.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ...2014-01-01 2014-01-01 false Exercise for dogs. 3.8 Section 3.8 ...Health and Husbandry Standards § 3.8 Exercise for dogs. Dealers, exhibitors...provide dogs with the opportunity for exercise. In addition, the plan must be...

  2. 9 CFR 3.8 - Exercise for dogs.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ...2012-01-01 2012-01-01 false Exercise for dogs. 3.8 Section 3.8 ...Health and Husbandry Standards § 3.8 Exercise for dogs. Dealers, exhibitors...provide dogs with the opportunity for exercise. In addition, the plan must be...

  3. 9 CFR 3.8 - Exercise for dogs.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ...2010-01-01 2010-01-01 false Exercise for dogs. 3.8 Section 3.8 ...Health and Husbandry Standards § 3.8 Exercise for dogs. Dealers, exhibitors...provide dogs with the opportunity for exercise. In addition, the plan must be...

  4. 46 CFR 386.19 - Dogs and other animals.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ...2013-10-01 2013-10-01 false Dogs and other animals. 386.19 Section...STATES MERCHANT MARINE ACADEMY § 386.19 Dogs and other animals. Persons are prohibited from bringing dogs and other animals on to the Academy...

  5. 50 CFR 28.43 - Destruction of dogs and cats.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ...2013-10-01 2013-10-01 false Destruction of dogs and cats. 28.43 Section 28.43 Wildlife and... Impoundment Procedures § 28.43 Destruction of dogs and cats. Dogs and cats running at large on a national wildlife...

  6. 50 CFR 36.36 - Sled dogs and household pets.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ...2014-10-01 2014-10-01 false Sled dogs and household pets. 36.36 Section... Other Refuge Uses § 36.36 Sled dogs and household pets. The general trespass...household pets and sled, work, or pack dogs under the direct control of their...

  7. Inheritance of coat colour in the field spaniel dog

    E-print Network

    Paris-Sud XI, Université de

    Note Inheritance of coat colour in the field spaniel dog R Robinson St Stephens Nursery, Stephens known as roan. dog genetics / coat colour / field spaniel / breed Résumé - Hérédité de la couleur du for the heredity of coat colour in the dog (Little, 1957; Robinson, 1990), it has become apparent as work

  8. Genetic Evidence for an East Asian Origin of Domestic Dogs

    Microsoft Academic Search

    Peter Savolainen; Ya-ping Zhang; Jing Luo; Joakim Lundeberg; Thomas Leitner

    2002-01-01

    The origin of the domestic dog from wolves has been established, but the number of founding events, as well as where and when these occurred, is not known. To address these questions, we examined the mitochondrial DNA (mtDNA) sequence variation among 654 domestic dogs representing all major dog populations worldwide. Although our data indicate several maternal origins from wolf, >95%

  9. 50 CFR 36.36 - Sled dogs and household pets.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ...2013-10-01 2013-10-01 false Sled dogs and household pets. 36.36 Section... Other Refuge Uses § 36.36 Sled dogs and household pets. The general trespass...household pets and sled, work, or pack dogs under the direct control of their...

  10. The conservation role of captive African wild dogs (Lycaon pictus)

    E-print Network

    Altwegg, Res

    The conservation role of captive African wild dogs (Lycaon pictus) M.A.J. Frantzen, J.W.H. Ferguson the long-term survival of the African wild dog (Lycaon pictus). To aid this, a studbook was assembled the largest existing regional population of captive African wild dogs. These populations were investigated

  11. 46 CFR 386.19 - Dogs and other animals.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ...2012-10-01 2012-10-01 false Dogs and other animals. 386.19 Section...STATES MERCHANT MARINE ACADEMY § 386.19 Dogs and other animals. Persons are prohibited from bringing dogs and other animals on to the Academy...

  12. 36 CFR 262.11 - Impounding of dogs.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ...2014-07-01 2014-07-01 false Impounding of dogs. 262.11 Section 262.11 Parks, Forests, and...Impoundments and Removals § 262.11 Impounding of dogs. Any dog found running at large in a part of the National...

  13. Port-access mitral valve replacement in dogs

    Microsoft Academic Search

    Mario F. Pompili; John H. Stevens; Thoms A. Burdon; Lawrence C. Siegel; William S. Peters; Greg H. Ribakove; Bruce A. Reitz

    1996-01-01

    Objective: The objective was to assess mitral valve replacement in a minimally invasive fashion by means of port-access technology. Methods: Fifteen dogs, 28 ± 3 kg (mean ± standard deviation), were studied with the port-access mitral valve replacement system (Heartport, Inc., Redwood City, Calif.). Eleven dogs underwent acute studies and were sacrificed immediately after the procedure. Four dogs were allowed

  14. 46 CFR 386.19 - Dogs and other animals.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ...2014-10-01 2014-10-01 false Dogs and other animals. 386.19 Section...STATES MERCHANT MARINE ACADEMY § 386.19 Dogs and other animals. Persons are prohibited from bringing dogs and other animals on to the Academy...

  15. 50 CFR 28.43 - Destruction of dogs and cats.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ...2014-10-01 2014-10-01 false Destruction of dogs and cats. 28.43 Section 28.43 Wildlife and... Impoundment Procedures § 28.43 Destruction of dogs and cats. Dogs and cats running at large on a national wildlife...

  16. Barking in domestic dogs: context specificity and individual identification

    E-print Network

    McCowan, Brenda

    Barking in domestic dogs: context specificity and individual identification SOPHIA YIN* & BRENDA acceptance 24 July 2003; MS. number: A9405R2) In this study we sought to determine whether dog barks could be divided into subtypes based on context. We recorded barking from 10 adult dogs, Canis familiaris, of six

  17. 36 CFR 262.11 - Impounding of dogs.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ...2012-07-01 2012-07-01 false Impounding of dogs. 262.11 Section 262.11 Parks, Forests, and...Impoundments and Removals § 262.11 Impounding of dogs. Any dog found running at large in a part of the National...

  18. 36 CFR 262.11 - Impounding of dogs.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ...2013-07-01 2013-07-01 false Impounding of dogs. 262.11 Section 262.11 Parks, Forests, and...Impoundments and Removals § 262.11 Impounding of dogs. Any dog found running at large in a part of the National...

  19. REVIEW ARTICLE Prevention of spontaneous bleeding in dogs with haemophilia

    E-print Network

    Kay, Mark A.

    REVIEW ARTICLE Prevention of spontaneous bleeding in dogs with haemophilia A and haemophilia B T. C of Pediatrics, Howard Hughes Medical Institute, Philadelphia, PA, USA Summary. Dogs with haemophilia in humans with severe haemophilia. The phenotypic and genotypic characteristics of haemophilic dogs have

  20. 50 CFR 28.43 - Destruction of dogs and cats.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ...2012-10-01 2012-10-01 false Destruction of dogs and cats. 28.43 Section 28.43 Wildlife and... Impoundment Procedures § 28.43 Destruction of dogs and cats. Dogs and cats running at large on a national wildlife...

  1. 50 CFR 36.36 - Sled dogs and household pets.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ...2012-10-01 2012-10-01 false Sled dogs and household pets. 36.36 Section... Other Refuge Uses § 36.36 Sled dogs and household pets. The general trespass...household pets and sled, work, or pack dogs under the direct control of their...

  2. Observational study of 14 cases of chronic pancreatitis in dogs

    Microsoft Academic Search

    P. J. Watson; J. Archer; A. J. Roulois; T. J. Scase; M. E. Herrtage

    2010-01-01

    This study reports the clinical, clinicopathological and ultrasonographic findings from dogs with chronic pancreatitis (CP). Fourteen dogs with clinical signs consistent with CP and histological confirmation of the disease were evaluated. Abdominal ultrasound and clinical pathology results were recorded. Sensitivities of pancreatic enzymes for diagnosis of CP were calculated with two different cut-off values. The mean age of affected dogs

  3. MRI of surgically created pulmonary artery narrowing in the dog

    Microsoft Academic Search

    R. J. Hernandez; A. P. Rocchini; E. L. Bove; T. L. Chenevert; B. Gubin

    1989-01-01

    Narrowing of the pulmonary arteries was created surgically in twelve dogs. In six of the dogs the narrowing was central (main pulmonary artery), and in the remaining six the narrowing was located peripherally at the hilar level of the right pulmonary artery beyond the pericardial reflection. MRI and angiography were performed in all dogs. MRI clearly delineated the site of

  4. Dogs' ( Canis familaris ) responsiveness to human pointing gestures

    Microsoft Academic Search

    Krisztina Soproni; Ádám Miklósi; József Topál; Vilmos Csányi

    2002-01-01

    In a series of 3 experiments, dogs (Canis familiaris) were presented with variations of the human pointing gesture: gestures with reversed direction of movement, cross-pointing, and different arm extensions. Dogs performed at above chance level if they could see the hand (and index finger) protruding from the human body contour. If these minimum requirements were not accessible, dogs still could

  5. A review of environmental enrichment for kennelled dogs, Canis familiaris

    Microsoft Academic Search

    Deborah L. Wells

    2004-01-01

    Domestic dogs can be housed in a variety of confined conditions, including kennels, shelters and laboratories. Concern over the well-being of dogs housed in human care has prompted much research in recent years into the enrichment of environments for kennelled dogs. This paper highlights the findings and recommendations arising from this work. Two types of general enrichment method are discussed,

  6. Inheritance of coat and colour in the Griffon Bruxellois dog

    E-print Network

    Boyer, Edmond

    and colour varieties in the Griffon Bruxellois, a toy breed of dog (2.2-4.9 kgs), which was developedNote Inheritance of coat and colour in the Griffon Bruxellois dog R Robinson St Stephens Nursery - The varieties of the Griffon Bruxellois dog consist of the colours black, red and black and tan, combined

  7. Behavioural Differences of Dogs of Various Ages in Czech Households

    Microsoft Academic Search

    E. BARANYIOVÁ; A. HOLUB; M. TYRLÍK; B. JANÁâKOVÁ; M. ERNSTOVÁ

    2004-01-01

    Baranyiová E., A. Holub, M. Tyrlík, B. Janáăková, M. Ernstová: Behavioural Differences of Dogs of Various Ages in Czech Households. Acta Vet. Brno 2004, 73: 229-233. The aim of the study was to evaluate the behaviour of dogs of various ages as viewed by their owners in the Czech Republic. The data were obtained in a questionnaire. The dogs were

  8. Owner Valuation of Rabies Vaccination of Dogs, Chad

    PubMed Central

    Dürr, Salome; Meltzer, Martin I.; Mindekem, Rolande

    2008-01-01

    We estimated the association between amount charged and probability that dog owners in N’Djaména, Chad, would have their dogs vaccinated against rabies. Owners would pay ?400–700 CFA francs (US $0.78–$1.36)/animal. To vaccinate >70% of dogs, and thus interrupt rabies transmission, health officials should substantially subsidize these vaccinations. PMID:18826838

  9. Dogs are able to solve a means-end task

    PubMed Central

    Range, Friederike; Hentrup, Marleen; Viranyi, Zsofia

    2014-01-01

    Dogs, although very skilled in social communicative tasks, have shown limited abilities in the domain of physical cognition. Consequently, several researchers hypothesized that domestication enhanced dogs’ cognitive abilities in the social realm, but relaxed selection on the physical one. For instance, dogs failed to demonstrate means-end understanding, an important form of relying on physical causal connection, when tested in a string-pulling task. Here, we tested dogs in an ‘on/off’ task using a novel approach. Thirty-two dogs were confronted with four different conditions in which they could choose between two boards one with a reward ‘on’ and another one with a reward ‘off’ (reward was placed next to the board). The dogs chose the correct board when 1) both rewards were placed at the same distance from the dog, when 2) the reward placed ‘on’ the board was closer to the dog, and 3) even when the reward placed ‘off’ the board was much closer to the dog and was food. Interestingly, in the latter case dogs did not perform above chance, if instead of a direct reward, the dogs had to retrieve an object placed on the board to get a food reward. In contrast to previous string pulling studies, our results show that dogs are able to solve a means-end task even if proximity of the unsupported reward is a confounding factor. PMID:21445577

  10. GENETIC MANAGEMENT OF DOG BREED POPULATIONS Ir. Ed. J. Gubbels

    E-print Network

    Lacy, Bob

    GENETIC MANAGEMENT OF DOG BREED POPULATIONS Ir. Ed. J. Gubbels May 2002 1. Introduction be combated with this system of individual selection at all. In the world of pure-bred dog breeding of inbreeding is gradually raised (via line breeding). The purpose is to fix the superior traits of dogs

  11. LATEX circa 2010 Teaching an Old Dog New Tricks

    E-print Network

    Hickman, Mark

    LATEX circa 2010 Teaching an Old Dog New Tricks Mark Hickman Department of Mathematics & Statistics 2010 Teaching an Old Dog New Tricks Mark Hickman Department of Mathematics & Statistics UniversityTeX\\ {\\em c i r c a } 2010}\\\\[3mm] 2 Teaching an Old Dog New Tricks } 3 \\ author {Mark Hickman\\\\ 4

  12. Original article Determination of selamectin in dog plasma by high

    E-print Network

    Paris-Sud XI, Université de

    Original article Determination of selamectin in dog plasma by high performance liquid of selamectin in dog plasma, using High-Per- formance Liquid Chromatography (HPLC) with fluorescence detection and its suitability was demonstrated by a pharmacokinetic study on a dog receiving the therapeutic dose

  13. Severe attacks by dogs: characteristics of the dogs, the victims, and the attack settings.

    PubMed Central

    Wright, J C

    1985-01-01

    Sixteen incidents involving dog bites fitting the description "severe" were identified among 5,711 dog bite incidents reported to health departments in five South Carolina counties (population 750,912 in 1980) between July 1, 1979, and June 30, 1982. A "severe" attack was defined as one in which the dog "repeatedly bit or vigorously shook its victim, and the victim or the person intervening had extreme difficulty terminating the attack." Information from health department records was clarified by interviews with animal control officers, health and police officials, and persons with firsthand knowledge of the events. Investigation disclosed that the dogs involved in the 16 severe attacks were reproductively intact males. The median age of the dogs was 3 years. A majority of the attacks were by American Staffordshire terriers, St. Bernards, and cocker spaniels. Ten of the dogs had been aggressive toward people or other dogs before the incident that was investigated. Ten of the 16 victims of severe attacks were 10 years of age or younger; the median age of all 16 victims was 8 years. Twelve of the victims either were members of the family that owned the attacking dog or had had contact with the dog before the attack. Eleven of the victims were bitten on the head, neck, or shoulders. In 88 percent of the cases, the attacks took place in the owner's yard or home, or in the adjoining yard. In 10 of the 16 incidents, members of the victims' families witnessed the attacks.(ABSTRACT TRUNCATED AT 250 WORDS) PMID:3918325

  14. How do guide dogs of blind owners and pet dogs of sighted owners ( Canis familiaris ) ask their owners for food?

    Microsoft Academic Search

    Florence Gaunet

    2008-01-01

    Although there are some indications that dogs (Canis familiaris) use the eyes of humans as a cue during human–dog interactions, the exact conditions under which this holds true are unclear.\\u000a Analysing whether the interactive modalities of guide dogs and pet dogs differ when they interact with their blind, and sighted\\u000a owners, respectively, is one way to tackle this problem; more

  15. Biological effects of {sup 137}CsCl injected in beagle dogs of different dogs

    SciTech Connect

    Nikula, K.J.; Boecker, B.B.; Griffith, W.C. [Inhalation Toxicology Research Institute, Albuquerque, NM (United States)] [and others

    1996-11-01

    The toxicity of {sup 137}Cs in the beagle dog was investigated at the Inhalation Toxicology Research Institute (ITRI) and Argonne National Laboratory (ANL) as part of programs to evaluate the biological effects of both radionuclides in atomic bomb fallout and internally deposited fission-product radionuclides. In the ITRI study, young adult dogs were exposed once by intravenous injection to a range of {sup 137}Cs concentrations; the results have recently been published. The purpose of the present report is to summarize the ANL study and to compare the results of the two studies. At ANL, 63 dogs in three age groups (15 juveniles, 142-151 days old; 38 young adults, 388-427 days old; and 10 middle-aged dogs, 1387-2060 days old) were given {sup 137}Cs intravenously at levels (61-162f MBq/kg) near those expected to be lethal within 30 days after injection. There were 17 control dogs from the same colony. Twenty-three of the dogs injected with {sup 137}Cs, including all middle-aged dogs, died within 52 days after injection due to hematopoietic cell damage resulting in severe pancytopenia that led to fatal hemorrhage and/or septicemia. The other significant early effect was damage to the germinal epithelium of the seminiferous tubules. The design of the ANL study revealed an age- and gender-related differential radiosensitivity for early effects. The middle-aged dogs died significantly earlier due to complications of hematological dyscrasia compared to the juvenile and young adult dogs, and the middle-aged females died significantly earlier than the middle-aged males. The most significant non-neoplastic late effects in the {sup 137}Cs-injected dogs from ANL and ITRI were atrophy of the germinal epithelium of seminiferous tubules with azoospermia, and a significant dose-dependent decrease in survival. The survival of the ANL dogs was decreased more than that of the ITRI dogs at similar radiation doses from {sup 137}Cs. 19 refs., 6 figs., 4 tabs.

  16. Retrospective study of 871 dogs with thrombocytopenia.

    PubMed

    Botsch, V; Küchenhoff, H; Hartmann, K; Hirschberger, J

    2009-05-23

    Eight hundred and seventy-one dogs with thrombocytopenia were divided into the following five categories: immune-mediated thrombocytopenia (49; 5.6 per cent), thrombocytopenia caused by disseminated intravascular coagulation (DIC) (52; 6.0 per cent), thrombocytopenia caused by miscellaneous disorders (222; 25.5 per cent), neoplasia-associated thrombocytopenia (244; 28 per cent) and inflammatory/infectious thrombocytopenia (304; 34.9 per cent). The incidence of thrombocytopenia among the hospital population was 6.7 per cent. The dogs with immune-mediated thrombocytopenia and thrombocytopenia caused by DIC had significantly (P<0.001) lower platelet counts (median 32.0 x 10(9)/l and 55.0 x 10(9)/l, respectively) than the dogs in the other three categories. PMID:19465753

  17. Country Dog Gentlemen Travel to Extraordinary Worlds

    NSDL National Science Digital Library

    This interactive gallery designed for children of all ages was produced by the Education Department of the San Francisco Museum of Modern Art (SFMOMA). In the interactive, the "Country Dog Gentlemen", characters first depicted in a 1972 painting of the same name by the late Bay Area artist Roy De Forest (1930-2007), lead explorations of paintings and sculpture by Frieda Kahlo, Jackson Pollack, and Sargent Johnson. Students can watch the dogs sniffing out the story of each work, or create their own art, in various activities inspired by the originals. For example, the activity based on Kahlo's portrait, Frieda and Diego Rivera, 1931, is to swap the clothing and pets in Kahlo's work. The questions the Country Dog Gentlemen ask about Sargent Johnson's sculpture Forever Free, 1933, could make a good Black History Month lesson.

  18. Lipid metabolism and hyperlipidemia in dogs.

    PubMed

    Xenoulis, Panagiotis G; Steiner, Jörg M

    2010-01-01

    Lipid metabolism in dogs can be divided into exogenous and endogenous pathways and exhibits some unique characteristics compared to other species. Hyperlipidemia is common in dogs, and can be either primary or secondary to other diseases. Secondary hyperlipidemia is the most common form and can be a result of endocrine disorders, pancreatitis, cholestasis, protein-losing nephropathy, obesity, and high fat diets. Primary hyperlipidemia is less common and usually associated with certain breeds. Hypertriglyceridemia of Miniature Schnauzers is the most common type of primary hyperlipidemia in dogs in the United States, and appears to have a genetic basis although its etiology remains unknown. Possible complications of canine hyperlipidemia include pancreatitis, liver disease, atherosclerosis, ocular disease, and seizures. Management is achieved by administration of low fat diets with or without the administration of lipid-lowering agents such as omega-3 fatty acids, gemfibrozil, and niacin. PMID:19167915

  19. Prevalence of Dirofilaria immitis, Ehrlichia canis, and Borrelia burgdorferi in pet dogs, racing greyhounds, and shelter dogs in Florida

    Microsoft Academic Search

    Nirit Tzipory; P. Cynda Crawford; Julie K. Levy

    2010-01-01

    Arthropod vectors of canine infectious diseases are present throughout Florida. Since crowded housing has the potential to bring vectors and infected dogs into close proximity, it is possible that prevalence of infection is higher in intensely housed dogs. In this study, the seroprevalence of Dirofilaria immitis, Ehrlichia canis, and Borrelia burgdorferi in dogs residing in two types of intensive housing,

  20. Dog Remains from Devon Island, N. WT. : Archaeological and Osteological Evidence for Domestic Dog Use in the Thule Culture

    Microsoft Academic Search

    ROBERT W. PARK

    A collection of dog bones recovered from a Thule culture site at Porden Point, Devon Island, N.W.T., was found to include abundant evidence of trauma consistent with the dogs having been repeatedly struck in the facial area. The proportional representation of bones found suggests that the Porden Point dogs ultimately formed part of the diet there. A survey of historical

  1. OIE guidelines on dog population control.

    PubMed

    Kahn, S; Stuardo, L; Rahman, S A

    2008-01-01

    At the 73rd General Session the OIE decided to develop guidance for Members on humane methods for the control of stray animal populations. In 2006, an ad hoc Group was convened under the leadership of the OIE Permanent Animal Welfare Working Group. With valuable assistance from the OIE Collaborating Centre on Animal Welfare, a Questionnaire was developed and sent to OIE Members, of which 81 countries submitted responses. In light of this information, the ad hoc Group prepared a first draft report, which notes the importance of controlling stray dog populations to help prevent zoonotic diseases and non-disease related nuisances to society and the environment. In choosing the preferred method of control, the risks to operators must be taken into account, as well as religious, cultural and economic contexts of the country concerned. Depending on the situation, methods requiring individual animal restraint or methods for use at a distance may be recommended. While activities that aim to physically reduce the numbers of stray dogs are important, achievement of the long term goals of dog population control and avoidance of risks to human health depends on the education of dog owners and the general public as to their responsibilities. The draft report notes that sub-national jurisdictions are often those responsible for the control of stray dog populations. The key role played by non-governmental organisations in stray dog management in many countries is acknowledged. The draft report emphasises that the close involvement of veterinarians and of official Veterinary Services, working in collaboration with public health authorities, is necessary to realise long term goals. PMID:18634514

  2. Genome sequencing highlights the dynamic early history of dogs.

    PubMed

    Freedman, Adam H; Gronau, Ilan; Schweizer, Rena M; Ortega-Del Vecchyo, Diego; Han, Eunjung; Silva, Pedro M; Galaverni, Marco; Fan, Zhenxin; Marx, Peter; Lorente-Galdos, Belen; Beale, Holly; Ramirez, Oscar; Hormozdiari, Farhad; Alkan, Can; Vilŕ, Carles; Squire, Kevin; Geffen, Eli; Kusak, Josip; Boyko, Adam R; Parker, Heidi G; Lee, Clarence; Tadigotla, Vasisht; Wilton, Alan; Siepel, Adam; Bustamante, Carlos D; Harkins, Timothy T; Nelson, Stanley F; Ostrander, Elaine A; Marques-Bonet, Tomas; Wayne, Robert K; Novembre, John

    2014-01-01

    To identify genetic changes underlying dog domestication and reconstruct their early evolutionary history, we generated high-quality genome sequences from three gray wolves, one from each of the three putative centers of dog domestication, two basal dog lineages (Basenji and Dingo) and a golden jackal as an outgroup. Analysis of these sequences supports a demographic model in which dogs and wolves diverged through a dynamic process involving population bottlenecks in both lineages and post-divergence gene flow. In dogs, the domestication bottleneck involved at least a 16-fold reduction in population size, a much more severe bottleneck than estimated previously. A sharp bottleneck in wolves occurred soon after their divergence from dogs, implying that the pool of diversity from which dogs arose was substantially larger than represented by modern wolf populations. We narrow the plausible range for the date of initial dog domestication to an interval spanning 11-16 thousand years ago, predating the rise of agriculture. In light of this finding, we expand upon previous work regarding the increase in copy number of the amylase gene (AMY2B) in dogs, which is believed to have aided digestion of starch in agricultural refuse. We find standing variation for amylase copy number variation in wolves and little or no copy number increase in the Dingo and Husky lineages. In conjunction with the estimated timing of dog origins, these results provide additional support to archaeological finds, suggesting the earliest dogs arose alongside hunter-gathers rather than agriculturists. Regarding the geographic origin of dogs, we find that, surprisingly, none of the extant wolf lineages from putative domestication centers is more closely related to dogs, and, instead, the sampled wolves form a sister monophyletic clade. This result, in combination with dog-wolf admixture during the process of domestication, suggests that a re-evaluation of past hypotheses regarding dog origins is necessary. PMID:24453982

  3. First isolation of Hammondia heydorni from dogs in China.

    PubMed

    Jie, Hu Jun; Yu, Meng; Fen, Yang Yan; Mei, Guo Yan; Yan, Yang; Esch, G W; QingTuan, Fu

    2013-10-18

    Fecal samples of 945 dogs were examined microscopically in 2 refuge facilities in China from March 2010 to November 2011. In 8 dogs, oocysts, 9-14 ?m in size, were found. Their morphology was similar to those of Hammondia heydorni and Neospora caninum. Sporulated Hammondia/Neospora-like oocysts were fed to 2 dogs, 2 gerbils, 2 guinea pigs, and 2 KM mice; tissues from these inoculated animals were then fed to coccidia-free dogs to determine species susceptibility to these oocysts. Oocysts were not excreted in the feces of dogs or rodents inoculated with oocysts. However, the dogs fed the tissues of gerbils or guinea pigs that were inoculated orally with oocysts excreted fresh oocysts. Dogs fed tissues from guinea pigs inoculated with brain and muscular homogenate from guinea pigs that were fed sporulated Hammondia/Neospora-like oocysts did not excrete oocysts. These findings indicated that the oocysts from naturally infected dogs had an obligatory 2-host life cycle, with gerbils and guinea pigs as intermediate hosts. DNA isolated from these oocysts could not be amplified using N. caninum- and Toxoplasma gondii-specific primers. However, positive amplification with the H. heydorni-specific primers confirmed the presence of H. heydorni DNA in the samples. A comparison of the intron 1 sequence of the alpha tubulin gene with those from H. heydorni from dogs and H. triffittae from foxes showed that dog-derived oocysts possessed a different alpha tubulin gene. Both our dog-derived sequence and 2 previous alpha tubulin gene sequences from H. triffittae from foxes contained a 9-bp insertion relative to 3 sequences of H. heydorni from dogs. However, when the 9-bp insertion from H. triffittae sequences were compared, the 9-bp insertion in our dog-derived sequence had a nucleotide substitution. The present study, therefore, provides new evidence of genetic diversity among isolates from dogs. This is the first survey for H. heydorni in dogs from China. PMID:23731857

  4. A Folk Tale of a Dog

    E-print Network

    Bkra shis bzang po

    2009-11-17

    Folk Tale of a Dog Translation of title Description (to be used in archive entry) Tshe 'dzin tells a folktale in which a dog helps three girls escape from a demon. Genre or type (i.e. epic, song, ritual) Folktale Name of recorder (if... different from collector) Bkra shis bzang po (Carver) Date of recording 17 November 2009 Place of recording Bang smad Village, Bang smad Township, Nyag rong County, Dkar mdzes Tibetan Autonomous Prefecture, Si khron Province Name(s), age, sex, place...

  5. Anthelmintic activity of paraherquamide in dogs.

    PubMed

    Shoop, W L; Eary, C H; Michael, B F; Haines, H W; Seward, R L

    1991-11-01

    Paraherquamide, an oxindole alkaloid metabolite of Penicillium paraherquei and Penicillium charlesii, was tested against the common gastrointestinal nematodes of dogs at a single oral dosage of 0.5, 1.0, or 2.0 mg kg-1. Efficacy was poor (less than 85%) against Ancylostoma caninum, Uncinaria stenocephala, Toxascaris leonina, Trichuris vulpis, and Strongyloides stercoralis at the low- and mid-dosage levels. At the high dosage level, good efficacy (91%) was observed only against S. stercoralis. Adverse reactions were observed in all dogs at every dosage level and included depression, ataxia, and protrusion of the nictitating membrane. PMID:1788941

  6. An Old Dog and New Tricks

    NASA Technical Reports Server (NTRS)

    Cameron, W. Scott

    2003-01-01

    As I approach my 55th birthday, the old adage 'you can't teach an old dog new tricks' keeps coming to mind. I'm not sure why, because I don't feel old and I'm still interested in taking on new challenges and learning new tricks. However, as I mentor new project managers, I am also aware that others may consider me an old dog unable to learn new tricks. To the contrary, the people I mentor continue to teach me new tricks and challenge my assumptions about project management.

  7. Regulation of Cholesterol Metabolism in the Dog

    PubMed Central

    Pertsemlidis, Demetrius; Kirchman, Ernest H.; Ahrens, E. H.

    1973-01-01

    Six adult pedigreed dogs were studied as long as 3 yr in order to determine the effects of cholesterol feeding and of bile diversion on absorption, synthesis, and storage of cholesterol. These measurements were based on cholesterol balance and isotope kinetic studies. In the six dogs fed a “cholesterol-free” diet with their enterohepatic circulations undisturbed, the rate of cholesterol synthesis ranged from 225 to 508 mg/day (mean 325 mg/day or 12.4 mg/kg/day). In two dogs studied subsequently on cholesterol-containing diets, absorption of cholesterol averaged 81% (range 71-94%) on a dietary intake of 0.5 g/day; on high cholesterol intakes (2.7-3.0 g/day) the rate of absorption dropped to 43-51% of daily intake, but the absolute amounts absorbed were increased. Feeding of cholesterol resulted in acceleration of bile acid formation and excretion, as well as nearly total inhibition of cholesterol synthesis. These two compensatory mechanisms were sufficient to maintain zero balance of cholesterol in the face of a high cholesterol intake. Plasma cholesterol concentrations in the two dogs increased by 37 and 44%. In two other dogs bile was completely diverted into the urinary system for nearly 2 yr. When these dogs were studied on a cholesterol-free diet, the sum of acidic steroids excreted daily in urine plus neutral steroids excreted in feces was seven times as high as before the operation. Since these massive excretory losses could not have been sustained by mobilization from tissue cholesterol pools, and since the rate of disappearance of [4-14C]cholesterol from the plasma after single intravenous injection was greatly increased after complete biliary diversion, total daily synthesis of cholesterol must have been greatly accelerated, for synthesis was totally unsuppressed. The increased output of fecal neutral steroids could be the result of transfer of plasma cholesterol across the gut wall or due to increased synthesis in the gut. Plasma cholesterol levels were reduced in these two dogs by 20 and 27%, and triglycerides decreased by 36 and 43%. Accumulation of cholesterol in body pools in the cholesterol-fed dogs appeared to have been prevented, according to antemortem measurements: increased absorption of dietary cholesterol was exactly balanced by suppression of cholesterol synthesis and enhanced bile acid excretion. In the bile-shunted animals, depletion of tissue stores of cholesterol could not be predicted by antemortem measurements. PMID:4727464

  8. Measurement of vertical ground reaction force in jumping dogs 

    E-print Network

    Yanoff, Susan Rena

    1991-01-01

    of other independent variables. Factors that were found to effect force were body weight, breed, and sex of the dog. Further studies are needed to determine the clinical significance of these findings. DEDICATION For Tristan, who had been through it all... of the jump, breed of dog, and sex of dog. The covariates were weight of dog, order in which the jumps were taken, and total number of jumps taken by each dog to get three valid readings. The dependent variables of interest were peak vertical ground...

  9. Serosurvey of dogs for Brucella canis infection in Memphis, Tennessee.

    PubMed

    Lovejoy, G S; Carver, H D; Moseley, I K; Hicks, M

    1976-02-01

    Following occurrence of a rare case of human Brucella canis in Memphis, Tennessee, the free roaming and confined dog populations of that community and a similar geographical location were surveyed for B canis positivity to identify the foci of infection and to compare positivity rates. Three hundred and two dogs were sampled. Positivity was found only in free roaming dogs in both communities. It is concluded that presence of B canis positivity in free roaming dogs may pose an additional medical threat to communities, thus providing one more sound reason for controlling strays and confining dogs. PMID:1251954

  10. Infection of Domestic Dogs in Peru by Zoonotic Bartonella Species: A Cross-Sectional Prevalence Study of 219 Asymptomatic Dogs

    PubMed Central

    Diniz, Pedro Paulo V. P.; Morton, Bridget A.; Tngrian, Maryam; Kachani, Malika; Barrón, Eduardo A.; Gavidia, Cesar M.; Gilman, Robert H.; Angulo, Noelia P.; Brenner, Elliott C.; Lerner, Richard; Chomel, Bruno B.

    2013-01-01

    Bartonella species are emerging infectious organisms transmitted by arthropods capable of causing long-lasting infection in mammalian hosts. Among over 30 species described from four continents to date, 15 are known to infect humans, with eight of these capable of infecting dogs as well. B. bacilliformis is the only species described infecting humans in Peru; however, several other Bartonella species were detected in small mammals, bats, ticks, and fleas in that country. The objective of this study was to determine the serological and/or molecular prevalence of Bartonella species in asymptomatic dogs in Peru in order to indirectly evaluate the potential for human exposure to zoonotic Bartonella species. A convenient sample of 219 healthy dogs was obtained from five cities and three villages in Peru. EDTA-blood samples were collected from 205 dogs, whereas serum samples were available from 108 dogs. The EDTA-blood samples were screened by PCR followed by nucleotide sequencing for species identification. Antibodies against B. vinsonii berkhoffii and B. rochalimae were detected by IFA (cut-off of 1?64). Bartonella DNA was detected in 21 of the 205 dogs (10%). Fifteen dogs were infected with B. rochalimae, while six dogs were infected with B. v. berkhoffii genotype III. Seropositivity for B. rochalimae was detected in 67 dogs (62%), and for B. v. berkhoffii in 43 (40%) of the 108 dogs. Reciprocal titers ?1?256 for B. rochalimae were detected in 19% of dogs, and for B. v. berkhoffii in 6.5% of dogs. This study identifies for the first time a population of dogs exposed to or infected with zoonotic Bartonella species, suggesting that domestic dogs may be the natural reservoir of these zoonotic organisms. Since dogs are epidemiological sentinels, Peruvian humans may be exposed to infections with B. rochalimae or B. v. berkhoffii. PMID:24040427

  11. "Like Owner, Like Dog": Correlation between the Owner's Attachment Profile and the Owner-Dog Bond

    PubMed Central

    Siniscalchi, Marcello; Stipo, Carlo; Quaranta, Angelo

    2013-01-01

    During recent years, several studies have revealed that human-dog relationships are based on a well-established and complex bond. There is now evidence suggesting that the dog–human affectional bond can be characterized as an “attachment”. The present study investigated possible association between the owners' attachment profile assessed throughout a new semi-projective test (the 9 Attachment Profile) and the owner-dog attachment bond evaluated using a modified version of those used in studying human infants: Ainsworth's “strange situation”. The findings represented the first evidence for the presence of a correlation between the owners' attachment profile and the owner-dog attachment bond throughout procedure and behavioural analyses involving controlled observations. PMID:24205235

  12. Fatal dog attacks in Canada, 1990–2007

    PubMed Central

    Raghavan, Malathi

    2008-01-01

    In Canada, public debates on dog attacks are dominated by studies from the United States. An electronic search of media reports in the Canadian Newsstand database, for the years 1990 to 2007, identified 28 fatalities from dog-bite injuries. Predominant factors in this case series were owned, known dogs; residential location; children’s unsupervised access to area with dogs; and rural/remote areas, including aboriginal reserves in the prairies. A higher proportion of sled dogs and, possibly, mixed-breed dogs in Canada than in the United States caused fatalities, as did multiple dogs rather than single dogs. Free-roaming dog packs, reported only from rural communities, caused most on-reserve fatalities. Future studies are needed to assess if this rural/urban divide is observed in nonfatal attacks and if the breeds that bite in Canada are different from the breeds that killed. Breed representation in this paper and, perhaps, multiple-dog overrepresentation should be understood in the context of the overall Canadian dog population. PMID:18624067

  13. Dogs can discriminate human smiling faces from blank expressions.

    PubMed

    Nagasawa, Miho; Murai, Kensuke; Mogi, Kazutaka; Kikusui, Takefumi

    2011-07-01

    Dogs have a unique ability to understand visual cues from humans. We investigated whether dogs can discriminate between human facial expressions. Photographs of human faces were used to test nine pet dogs in two-choice discrimination tasks. The training phases involved each dog learning to discriminate between a set of photographs of their owner's smiling and blank face. Of the nine dogs, five fulfilled these criteria and were selected for test sessions. In the test phase, 10 sets of photographs of the owner's smiling and blank face, which had previously not been seen by the dog, were presented. The dogs selected the owner's smiling face significantly more often than expected by chance. In subsequent tests, 10 sets of smiling and blank face photographs of 20 persons unfamiliar to the dogs were presented (10 males and 10 females). There was no statistical difference between the accuracy in the case of the owners and that in the case of unfamiliar persons with the same gender as the owner. However, the accuracy was significantly lower in the case of unfamiliar persons of the opposite gender to that of the owner, than with the owners themselves. These results suggest that dogs can learn to discriminate human smiling faces from blank faces by looking at photographs. Although it remains unclear whether dogs have human-like systems for visual processing of human facial expressions, the ability to learn to discriminate human facial expressions may have helped dogs adapt to human society. PMID:21359654

  14. Fatal dog attacks in Canada, 1990-2007.

    PubMed

    Raghavan, Malathi

    2008-06-01

    In Canada, public debates on dog attacks are dominated by studies from the United States. An electronic search of media reports in the Canadian Newsstand database, for the years 1990 to 2007, identified 28 fatalities from dog-bite injuries. Predominant factors in this case series were owned, known dogs; residential location; children's unsupervised access to area with dogs; and rural/remote areas, including aboriginal reserves in the prairies. A higher proportion of sled dogs and, possibly, mixed-breed dogs in Canada than in the United States caused fatalities, as did multiple dogs rather than single dogs. Free-roaming dog packs, reported only from rural communities, caused most on-reserve fatalities. Future studies are needed to assess if this rural/urban divide is observed in nonfatal attacks and if the breeds that bite in Canada are different from the breeds that killed. Breed representation in this paper and, perhaps, multiple-dog overrepresentation should be understood in the context of the overall Canadian dog population. PMID:18624067

  15. Filarial infections in domestic dogs in Lusaka, Zambia.

    PubMed

    Siwila, Joyce; Mwase, Enala T; Nejsum, Peter; Simonsen, Paul E

    2015-06-15

    Filariae are common parasites of dogs in many parts of the world, but little is known about the status of these infections in sub-Saharan Africa. A study was carried out to determine the occurrence and species of filariae among 272 dogs in Lusaka, Zambia. Giemsa stained blood smear and Knott's concentration methods revealed microfilariae in 16 (5.9%) of the dogs. PCR confirmed that most of these dogs had Acanthocheilonema reconditum infection. Ten (4.0%) of the examined dogs were positive for Dirofilaria immitis circulating antigen (by DiroCHEK(®) test), but D. immitis microfilariae were not identified in any of the dogs and the status of this infection remains unclear. Further studies are needed to explore the occurrence of filariae in Zambian dogs and the zoonotic potential for humans. PMID:25944406

  16. Reclaiming identity through service to dogs in need.

    PubMed

    Alers, Elvin V; Simpson, Kevin M

    2012-01-01

    Dog Tags is an animal-assisted therapy offered by the Washington Humane Society (WHS) in partnership with the Walter Reed National Military Medical Center (WRNMMC). The program is open to all ranks of enlisted service members using WRNMMC services. Dog Tags is a 3-tiered certificate program allowing Soldiers, recovering at WRNMMC, to learn and apply progressively complex and challenging elements of canine positive reinforcement training to dogs awaiting adoption at the WHS. Although each tier is a self-contained and complete curriculum, subsequent tiers build on the skills and knowledge acquired in the previous one(s). Dog Tags Warrior/trainers work with fully-screened (health and temperament) shelter dogs to provide these dogs with mental stimulation, environmental enrichment, and socialization that are vital to their successful adoption and integration into new homes. The Soldiers also benefit because they develop new skills, build positive bonds with the dogs, and continue to serve their community. PMID:22388686

  17. Positive affect and learning: exploring the "Eureka Effect" in dogs.

    PubMed

    McGowan, Ragen T S; Rehn, Therese; Norling, Yezica; Keeling, Linda J

    2014-05-01

    Animals may experience positive affective states in response to their own achievements. We investigated emotional responses to problem-solving in dogs, separating these from reactions to rewards per se using a yoked control design. We also questioned whether the intensity of reaction would vary with reward type. We examined the response (behavior and heart rate) of dogs as they learned to gain access to different rewards: (1) food (2) human contact, and (3) dog contact. Twelve beagles were assigned to matched pairs, and each dog served as both an experimental and a control animal during different stages of the experiment. We trained all dogs to perform distinct operant tasks and exposed them to additional devices to which they were not trained. Later, dogs were tested in a new context. When acting as an experimental dog, access to the reward was granted immediately upon completion of trained operant tasks. When acting as a control, access to the reward was independent of the dog's actions and was instead granted after a delay equal to their matched partner's latency to complete their task. Thus, differences between the two situations could be attributed to experimental dogs having the opportunity to learn to control access to the reward. Experimental dogs showed signs of excitement (e.g., increased tail wagging and activity) in response to their achievements, whereas controls showed signs of frustration (e.g., chewing of the operant device) in response to the unpredictability of the situation. The intensity of emotional response in experimental dogs was influenced by the reward type, i.e., greatest response to food and least to another dog. Our results suggest that dogs react emotionally to problem-solving opportunities and that tail wagging may be a useful indicator of positive affective states in dogs. PMID:24096703

  18. Insect vector-mediated transmission of plant viruses.

    PubMed

    Whitfield, Anna E; Falk, Bryce W; Rotenberg, Dorith

    2015-05-01

    The majority of plant-infecting viruses are transmitted to their host plants by vectors. The interactions between viruses and vector vary in duration and specificity but some common themes in vector transmission have emerged: 1) plant viruses encode structural proteins on the surface of the virion that are essential for transmission, and in some cases additional non-structural helper proteins that act to bridge the virion to the vector binding site; 2) viruses bind to specific sites in or on vectors and are retained there until they are transmitted to their plant hosts; and 3) viral determinants of vector transmission are promising candidates for translational research aimed at disrupting transmission or decreasing vector populations. In this review, we focus on well-characterized insect vector-transmitted viruses in the following genera: Caulimovirus, Crinivirus, Luteovirus, Geminiviridae, Reovirus, Tospovirus, and Tenuivirus. New discoveries regarding these genera have increased our understanding of the basic mechanisms of virus transmission by arthropods, which in turn have enabled the development of innovative strategies for breaking the transmission cycle. PMID:25824478

  19. Iatrogenic keratoconjunctivitis sicca in a dog

    Microsoft Academic Search

    Denise Eliza de Almeida; Fabricio Villela Mamede; Juan Pablo Duque Ortiz; José Luiz Laus

    2004-01-01

    Qualitative and quantitative abnormalities in primary components of the tear can alter the dynamics of the lacrimal film, compromising its function. Lipids, an aqueous fraction and mucoproteins constitute the lacrimal film. Keratoconjunctivitis sicca (KCS) is a disease commonly diagnosed in dogs. It is characterized by the deficiency of the aqueous fraction in the lacrimal film that results in dryness, inflammation

  20. Is fentanyl an anesthetic in the dog?

    PubMed

    Bailey, P L; Port, J D; McJames, S; Reinersman, L; Stanley, T H

    1987-06-01

    The authors used the absence of vocalization and movement during application of a hemostat clamped to the first ratchet at the base of the tail as an indication of anesthesia for evaluation of the anesthetic properties of fentanyl in the dog. Eighty-six unpremedicated, unrestrained, untrained mongrel dogs were given one of eight doses of fentanyl citrate (125, 250, 500, 750, 1000, 1500, 2000, and 3000 micrograms/kg) as a single intravenous bolus injection. Dogs breathed spontaneously without oxygen supplementation. Anesthesia was assessed every 5 min until absence of anesthesia was recorded for two consecutive evaluations. Venous plasma samples were obtained in two or three dogs receiving each of the doses of fentanyl 5 min after fentanyl injection and again when application of the tail clamp elicited either vocalization or movement (positive response). Fentanyl resulted in recumbency in all animals except two receiving 125 micrograms/kg. Although all doses of fentanyl produced anesthesia in at least one animal 5 min after injection, the duration of anesthesia was short, responses unpredictable, and anesthesia achieved in all animals only with a dose of 3000 micrograms/kg. Increasing doses of fentanyl resulted in higher plasma fentanyl concentrations 5 min after injection and at the time of the first positive response to tail clamp but there was great variability. All doses of fentanyl caused statistically significant decreases in heart and respiratory rates but none produced apnea or a PaCO2 higher than 67 mm Hg.(ABSTRACT TRUNCATED AT 250 WORDS) PMID:3107433

  1. Canine kobuviruses in diarrhoeic dogs in Italy.

    PubMed

    Di Martino, Barbara; Di Felice, Elisabetta; Ceci, Chiara; Di Profio, Federica; Marsilio, Fulvio

    2013-09-27

    Canine kobuviruses (CaKVs) are newly recognized picornaviruses recently detected in dogs in the US. By molecular analysis of the whole genome, CaKV that appeared genetically closest to the murine kobuvirus (MuKV) and to the human Aichi virus (AiV), may be classified in the Kobuvirus genus as new genotype (CaKV type 1) within the species Aichivirus A. To date, there are no information on the epidemiology of these novel viruses in other continents. In this study, by screening a collection of 256 dog fecal samples either from diarrhoeic or asymptomatic animals, CaKV was identified in six specimens with an overall prevalence of 2.34% (6/256). All the positive dogs presented diarrhea and were found to be infected by CaKV alone or in mixed infections with canine coronavirus (CCoV) and/or canine parvovirus type 2 (CPV-2). By molecular analysis of the partial 3D gene, all the strains detected displayed a close relatedness with the CaKVs recently identified in the US. This study provides evidence that CaKVs circulate in diarrhoeic dogs in Italy and are not geographically restricted to the North American continent, where they were first signaled. PMID:23806200

  2. Neosporosis in a dog in Italy

    Microsoft Academic Search

    P Pasquali; M. T Mandara; F Adamo; G Ricci; G. A Polidori; J. P Dubey

    1998-01-01

    Clinical neosporosis was diagnosed in a 2-month-old Pit Bull Terrier from Italy. Neospora caninum tachyzoites were found in semitendinosus muscle with myositis. The diagnosis was confirmed by immunohistochemical staining with anti-N. caninum specific antibodies. This is the first report of systemic neosporosis in dogs from Italy.

  3. Neosporosis in a dog in Italy.

    PubMed

    Pasquali, P; Mandara, M T; Adamo, F; Ricci, G; Polidori, G A; Dubey, J P

    1998-06-30

    Clinical neosporosis was diagnosed in a 2-month-old Pit Bull Terrier from Italy. Neospora caninum tachyzoites were found in semitendinosus muscle with myositis. The diagnosis was confirmed by immunohistochemical staining with anti-N. caninum specific antibodies. This is the first report of systemic neosporosis in dogs from Italy. PMID:9763320

  4. Trapped Prairie Dog for SPV Testing

    USGS Multimedia Gallery

    This prairie dog was trapped by scientists outside its burrow in Wind Cave National Park as part of a field test to determine the effectiveness of a USGS-developed oral sylvatic plague vaccine (SPV). This animal will be brought to a research van for tagging and blood, whisker, and hair sampling, and...

  5. Trapping Prairie Dogs for Vaccine Testing

    USGS Multimedia Gallery

    Greg Schroeder (National Park Service) and a pair of Auburn University graduate students approach a prairie dog that has been trapped outside its burrow in Wind Cave National Park. The animal is part of a field test to determine the effectiveness of a USGS-developed oral sylvatic plague vaccine...

  6. Biosynthetic Corneal Substitute Implantation in Dogs

    PubMed Central

    Bentley, Ellison; Murphy, Christopher J.; Li, Fengfu; Carlsson, David J.; Griffith, May

    2012-01-01

    Purpose To assess integration of a biosynthetic corneal implant in dogs. Methods Three normal adult laboratory Beagles underwent ophthalmic examinations, including slit-lamp biomicroscopy, indirect ophthalmoscopy, applanation tonometry, and Cochet–Bonnet aesthesiometry. Biosynthetic corneas fabricated from glutaraldehyde crosslinked collagen and copolymers of collagen and poly (N-isopropylacrylamide-co-acrylic acid-co-acryloxysuccinimide, denoted as TERP) were implanted into dogs by a modified epikeratoplasty technique. Ophthalmic examinations and aesthesiometry were performed daily for 5 days and then weekly thereafter for 16 weeks. Corneal samples underwent histopathological and transmission electron microscopy examination at 16 weeks. Results Implants were epithelialized by 7 days. Intraocular pressure was within normal range throughout the study. Aesthesiometry values dropped from an average of 3.67 cm preoperatively to less than 1 mm for all dogs for the first postoperative weeks. By week 16, the average Cochet–Bonnet value was 1.67 cm, demonstrating partial recovery of functional innervation of the implant. No inflammation or rejection of the implant occurred, and minimal haze formation was noted. Light microscopy revealed thickened but normal epithelium over the implant with fibroblast migration into the scaffold. On transmission electron microscopy, the basement membrane was irregular but present and adhesion complexes were noted. Conclusion Biosynthetic corneal implantation is well tolerated in dogs, and the collagen–polymer hybrid construct holds promise for clinical application in animals and humans. PMID:20539221

  7. Listeria monocytogenes septicemia in an immunocompromised dog

    Technology Transfer Automated Retrieval System (TEKTRAN)

    An 11-year-old, male castrated, Boston terrier was presented to the North Carolina State University College of Veterinary Medicine Small Animal Emergency Service (NCSU-CVM-SAER) with a two-day history of progressive ataxia, left-sided head tilt, and anorexia. The dog had previously been diagnosed wi...

  8. Heartworm in dogs in Canada in 1988

    PubMed Central

    Slocombe, J. Owen D.; McMillan, Ian

    1989-01-01

    In late November 1988, 1581 small and mixed animal clinics and institutional veterinarians across Canada were sent a questionnaire in order to assess the status of Dirofilaria immitis in Canada in 1988, and 46% of them responded. Veterinarians reported that 181,577 dogs were blood-tested for heartworm disease and 367 dogs were found with D. immitis microfilariae. Another 60 dogs were amicrofilaremic but diagnosed with heartworm disease to give the total number of cases diagnosed in 1988 as 441 (0.24%). Heartworm was reported from Alberta, Manitoba, Ontario, Quebec, Nova Scotia and New Brunswick, but most (389) of the cases were from Ontario. South-western Ontario continued to be the primary focus of the infection in Canada. There were 22 cases reported from Quebec, mostly from and around Montreal, and 24 from Manitoba, mostly from Selkirk, Winnipeg and surrounding areas. Heartworm was found most frequently in companion dogs over three years of age maintained mainly outdoors in rural areas. About 76% of the cases had a history of not having left Canada, and 24% were observed with clinical signs of heartworm disease. PMID:17423348

  9. Heartworm in Dogs in Canada in 1986

    PubMed Central

    Owen, J.; Slocombe, D.; McMillan, Ian

    1987-01-01

    In late December 1986, 1224 institutional veterinarians and small and mixed animal clinics across Canada were sent a questionnaire in order to assess the status of Dirofilaria immitis in Canada in 1986; 46% of them responded. Veterinarians reported that 150,989 dogs were blood-tested for microfilariae and 869 dogs were found with heartworm. Another 65 dogs were amicrofilaremic but diagnosed with heartworm disease and one was found with heartworm at necropsy to give the total number diagnosed in 1986 as 935 (0.62%). Heartworm was reported from Manitoba, New Brunswick, Ontario and Quebec, but most (810) of the cases were from Ontario. South-western Ontario continued to be the primary focus of the infection in Canada. There were 103 cases reported from Quebec, mostly from and around Montreal, and 21 cases from Manitoba, from Winnipeg and surrounding areas. Heartworm was found most frequently in companion dogs over three years of age maintained mainly outdoors in rural areas. About 33% of the cases were observed with clinical signs of heartworm disease and 81% had a history of not having left Canada. ImagesFigure 1.Figure 2. PMID:17422840

  10. Diagnosis of pancreatitis in dogs and cats.

    PubMed

    Xenoulis, P G

    2015-01-01

    Pancreatitis is the most common disorder of the exocrine pancreas in both dogs and cats. Ante-mortem diagnosis of canine and feline pancreatitis can be challenging. The clinical picture of dogs and cats with pancreatitis varies greatly (from very mild to severe or even fatal) and is characterised by non-specific findings. Complete blood count, serum biochemistry profile and urinalysis should always be performed in dogs and cats suspected of having pancreatitis, although findings are not-specific for pancreatitis. Serum amylase and lipase activities and trypsin-like immunoreactivity (TLI) concentrations have no or only limited clinical value for the diagnosis of pancreatitis in either dogs or cats. Conversely, serum pancreatic lipase immunoreactivity (PLI) concentration is currently considered to be the clinicopathological test of choice for the diagnosis of canine and feline pancreatitis. Abdominal radiography is a useful diagnostic tool for the exclusion of other diseases that may cause similar clinical signs to those of pancreatitis. Abdominal ultrasonography can be very useful for the diagnosis of pancreatitis, but this depends largely on the clinician's experience. Histopathological examination of the pancreas is considered the gold standard for the diagnosis and classification of pancreatitis, but it is not without limitations. In clinical practice, a combination of careful evaluation of the animal's history, serum PLI concentration and abdominal ultrasonography, together with pancreatic cytology or histopathology when indicated or possible, is considered to be the most practical and reliable means for an accurate diagnosis or exclusion of pancreatitis compared with other diagnostic modalities. PMID:25586803

  11. Are dogs, cats, and raccoons color blind?

    Microsoft Academic Search

    F. M. Gregg; E. Jamison; R. Wilkie; T. Radinsky

    1929-01-01

    Using an apparatus similar to the one used by Gregg and McPheeters in their Chicago experiments with raccoons, the authors trained a dog, a cat, and a raccoon to discriminate between combinations of colors which were not equated for brightness differences during the training period. When the \\

  12. Fatal diphenhydramine poisoning in a dog

    PubMed Central

    Buchweitz, John P.; Raverty, Stephen A.; Johnson, Margaret B.; Lehner, Andreas F.

    2014-01-01

    We report a fatal diphenhydramine poisoning of a 10-year-old, male poodle-cross dog with pre-existing conditions and suspected co-ingestion of ethanol. This case illustrates that diphenhydramine overdose can be fatal in certain circumstances and that analytical toxicology may play an important role in animal death investigations. PMID:25392554

  13. Clifford, The Big Red Dog K-1

    NSDL National Science Digital Library

    Mrs. Bourne

    2006-10-16

    Learning to read and write can be so much fun. Clifford, The Big Red Dog, wants to help you. Listen to a story. Here, Clifford Write a message to Clifford. Send a Note Play the Sound Match Game with Clifford. Clifford s Sound Match Game Help Clifford at the beach. Games Match your letters in the Letter Match Game. Letter Match ...

  14. A cross-sectional study of factors associated with dog ownership in Tanzania

    Microsoft Academic Search

    Darryn L Knobel; M Karen Laurenson; Rudovick R Kazwala; Lisa A Boden; Sarah Cleaveland

    2008-01-01

    BACKGROUND: Mass vaccination of owned domestic dogs is crucial for the control of rabies in sub-Saharan Africa. Knowledge of the proportion of households which own dogs, and of the factors associated with dog ownership, is important for the planning and implementation of rabies awareness and dog vaccination programmes, and for the promotion of responsible dog ownership. This paper reports the

  15. STS-69 Crew members display 'Dog Crew' patches

    NASA Technical Reports Server (NTRS)

    1995-01-01

    Following their arrival at KSC's Shuttle Landing Facility, the five astronauts assigned to Space Shuttle Mission STS-69 display the unofficial crew patch for their upcoming spaceflight: the Dog Crew II patch. Mission Commander David M. Walker (center) and Payload Commander James S. Voss (second from right) previously flew together on Mission STS-53, the final dedicated Department of Defense flight on the Space Shuttle. A close comradery formed among Walker, Voss and the rest of the crew, and they dubbed themselves the 'dogs of war', with each of the STS-53 'Dog Crew' members assigned a 'dog tag' or nickname. When the STS-69 astronauts also became good buddies, they decided it was time for the Dog Crew II to be named. Walker's dog tag is Red Dog, Voss's is Dogface, Pilot Kenneth D. Cockrell (second from left) is Cujo, space rookie and Mission Specialist Michael L. Gernhardt (left) is Under Dog, and Mission Specialist James H. Newman (right) is Pluato. The Dog Crew II patch features a bulldog peering out from a doghouse shaped like the Space Shuttle and lists the five crew member's dog names. The five astronauts are scheduled to lift off on the fifth Shuttle flight of the year at 11:04 a.m. EDT, August 31, aboard the Space Shuttle Endeavour.

  16. Successful experimental challenge of dogs with canine parvovirus-2.

    PubMed Central

    Carman, S; Povey, C

    1982-01-01

    Withholding food from dogs for 24 hours prior to, and for 48 hours following oral challenge with a gut mucosal homogenate of canine parvovirus-2, was a successful means of reproducing gastroenteric signs of canine parvovirus-2 infection. Twenty-one of 24 dogs, which had previously received various vaccine preparations of mink enteritis virus or were unvaccinated, and which were starved at challenge, developed soft or liquid feces with large or without large clots of mucus. Altered feces were most frequent on postexposure day 11. Seven dogs passed frank blood in their stools on one or more occasions and seven dogs vomited sporadically. Pyrexia was noted in 71.6% of the dogs on postexposure day 6 and lymphopenia was detected on postexposure day 5 or 6 in 50% of the dogs monitored. In contrast, four dogs not starved at the time of challenge remained free of gastrointestinal signs apart from one dog which passed a soft stool with scant mucus on one day, postexposure day 6. Also four dogs vaccinated with a killed canine parvovirus-2 vaccine preparation and subsequently starved at the time of challenge, remained clinically healthy. Apart from these last mentioned four dogs, all others shed canine parvovirus-2 in their feces following challenge. Images Fig. 1. Fig. 2. PMID:6280819

  17. Prevalence of Dirofilaria immitis, Ehrlichia canis, and Borrelia burgdorferi in pet dogs, racing greyhounds, and shelter dogs in Florida.

    PubMed

    Tzipory, Nirit; Crawford, P Cynda; Levy, Julie K

    2010-07-15

    Arthropod vectors of canine infectious diseases are present throughout Florida. Since crowded housing has the potential to bring vectors and infected dogs into close proximity, it is possible that prevalence of infection is higher in intensely housed dogs. In this study, the seroprevalence of Dirofilaria immitis, Ehrlichia canis, and Borrelia burgdorferi in dogs residing in two types of intensive housing, greyhound kennels and animal shelters, was compared to dogs residing in low-intensity housing, private homes. Serum was collected from a cross-section of 1500 adult dogs from Florida, including 500 pet dogs referred to the Veterinary Medical Center of the College of Veterinary Medicine at the University of Florida, 500 racing greyhounds, and 500 dogs residing in animal shelters. Serum was tested for D. immitis antigen, E. canis antibodies, and B. burgdorferi antibodies by ELISA. Seroprevalence of D. immitis was significantly higher (14.6%) in shelter dogs and in pet dogs (1.4%) than in racing greyhounds (0.2%) (P<0.04). There were no significant differences in the seroprevalence of E. canis (0.4-1.6%) or B. burgdorferi (0-0.8%) among the groups. There was no association of sex or age with D. immitis infection, but pit bull type dogs were more than twice as likely to be infected than other breeds (P=0.003). Evidence for vector-borne infections, particularly D. immitis, was found in dogs throughout the state. The prevalence was greatest for D. immitis infection in shelter dogs, likely due to lack of preventive medications prior to impoundment. Although heartworm infection is considered to be a treatable condition, insufficient resources in shelters may lead to euthanasia of infected dogs that would otherwise be considered adoptable. PMID:20399018

  18. 9 CFR 318.12 - Manufacture of dog food or similar uninspected article at official establishments.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 2013-01-01 false Manufacture of dog food or similar uninspected article at official... General § 318.12 Manufacture of dog food or similar uninspected article at official establishments. (a) When dog food, or similar...

  19. 49 CFR 236.335 - Dogs, stops and trunnions of mechanical locking.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ...2012-10-01 2012-10-01 false Dogs, stops and trunnions of mechanical locking... Rules and Instructions § 236.335 Dogs, stops and trunnions of mechanical locking. Driving pieces, dogs, stops and trunnions shall be...

  20. 9 CFR 2.132 - Procurement of dogs, cats, and other animals; dealers.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ...2013-01-01 false Procurement of dogs, cats, and other animals; dealers...Miscellaneous § 2.132 Procurement of dogs, cats, and other animals; dealers...dealer may obtain live random source dogs and cats only from: (1) Other...

  1. 9 CFR 2.132 - Procurement of dogs, cats, and other animals; dealers.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ...2012-01-01 false Procurement of dogs, cats, and other animals; dealers...Miscellaneous § 2.132 Procurement of dogs, cats, and other animals; dealers...dealer may obtain live random source dogs and cats only from: (1) Other...

  2. 9 CFR 318.12 - Manufacture of dog food or similar uninspected article at official establishments.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 2012-01-01 false Manufacture of dog food or similar uninspected article at official... General § 318.12 Manufacture of dog food or similar uninspected article at official establishments. (a) When dog food, or similar...

  3. 49 CFR 236.338 - Mechanical locking required in accordance with locking sheet and dog chart.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ...required in accordance with locking sheet and dog chart. 236.338 Section 236.338...required in accordance with locking sheet and dog chart. Mechanical locking shall be in accordance with locking sheet and dog chart currently in...

  4. 33 CFR 147.839 - Mad Dog Truss Spar Platform safety zone.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ...2014-07-01 2014-07-01 false Mad Dog Truss Spar Platform safety zone. 147...ACTIVITIES SAFETY ZONES § 147.839 Mad Dog Truss Spar Platform safety zone. (a) Description. Mad Dog Truss Spar Platform, Green Canyon 782...

  5. 9 CFR 2.132 - Procurement of dogs, cats, and other animals; dealers.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ...2014-01-01 false Procurement of dogs, cats, and other animals; dealers...Miscellaneous § 2.132 Procurement of dogs, cats, and other animals; dealers...dealer may obtain live random source dogs and cats only from: (1) Other...

  6. 9 CFR 318.12 - Manufacture of dog food or similar uninspected article at official establishments.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 2014-01-01 false Manufacture of dog food or similar uninspected article at official... General § 318.12 Manufacture of dog food or similar uninspected article at official establishments. (a) When dog food, or similar...

  7. 33 CFR 147.839 - Mad Dog Truss Spar Platform safety zone.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ...2013-07-01 2013-07-01 false Mad Dog Truss Spar Platform safety zone. 147...ACTIVITIES SAFETY ZONES § 147.839 Mad Dog Truss Spar Platform safety zone. (a) Description. Mad Dog Truss Spar Platform, Green Canyon 782...

  8. 33 CFR 147.839 - Mad Dog Truss Spar Platform safety zone.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ...2012-07-01 2012-07-01 false Mad Dog Truss Spar Platform safety zone. 147...ACTIVITIES SAFETY ZONES § 147.839 Mad Dog Truss Spar Platform safety zone. (a) Description. Mad Dog Truss Spar Platform, Green Canyon 782...

  9. 49 CFR 236.338 - Mechanical locking required in accordance with locking sheet and dog chart.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ...required in accordance with locking sheet and dog chart. 236.338 Section 236.338...required in accordance with locking sheet and dog chart. Mechanical locking shall be in accordance with locking sheet and dog chart currently in...

  10. 49 CFR 236.338 - Mechanical locking required in accordance with locking sheet and dog chart.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ...required in accordance with locking sheet and dog chart. 236.338 Section 236.338...required in accordance with locking sheet and dog chart. Mechanical locking shall be in accordance with locking sheet and dog chart currently in...

  11. 49 CFR 236.335 - Dogs, stops and trunnions of mechanical locking.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ...2014-10-01 2014-10-01 false Dogs, stops and trunnions of mechanical locking... Rules and Instructions § 236.335 Dogs, stops and trunnions of mechanical locking. Driving pieces, dogs, stops and trunnions shall be...

  12. 49 CFR 236.335 - Dogs, stops and trunnions of mechanical locking.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ...2013-10-01 2013-10-01 false Dogs, stops and trunnions of mechanical locking... Rules and Instructions § 236.335 Dogs, stops and trunnions of mechanical locking. Driving pieces, dogs, stops and trunnions shall be...

  13. SOCIAL GROUP FISSION AND GENE DYNAMICS AMONG BLACK-TAILED PRAIRIE DOGS

    E-print Network

    Foltz, David W.

    SOCIAL GROUP FISSION AND GENE DYNAMICS AMONG BLACK-TAILED PRAIRIE DOGS (CYNOMYS LUDOVICIANUS fission. Key words: coancestry, competition, cooperation, Cynomys ludovicianus, dispersal, fission, gene al. 1990). Black-tailed prairie dogs (Cynomys ludovicianus; hereafter, simply ``prairie dogs

  14. Lipoprotein metabolism and LCAT activity in chronic renal failure dogs supplemented with PUFA oils 

    E-print Network

    Malcik, Kimberly L

    1996-01-01

    Serum total cholesterol (TC), lipoprotein cholesterol distribution, and lecithin:cholesterol acyltransferase (LCAT) activities of chronic renal failure dogs were investigated. Control dogs (n = 14) and affected dogs (n = 29) were fed one of three...

  15. Blood vitamin levels in dogs with chronic kidney disease.

    PubMed

    Galler, A; Tran, J L; Krammer-Lukas, S; Höller, U; Thalhammer, J G; Zentek, J; Willmann, M

    2012-05-01

    Chronic kidney disease (CKD) may affect excretion and metabolism of vitamins but data for dogs are limited. In this study, blood vitamin levels were investigated in 19 dogs with chronic renal failure. High performance liquid chromatography was used to quantify retinol, retinyl esters, tocopherol, thiamine, riboflavin, pyridoxal-5'-phosphate, ascorbic acid and 25-hydroxycholecalciferol concentrations, whereas cobalamin, folate, biotin and pantothenic acid were measured by microbiological methods. Levels of retinol, retinyl palmitate, ascorbic acid, and vitamins B1, B2 and B6 were increased compared to healthy dogs. Dogs with CKD showed decreased concentrations of 25-hydroxycholecalciferol and folate. Alpha-tocopherol, biotin, pantothenate and cobalamin levels were not significantly different between controls and dogs with CKD. Whether lower vitamin D and folate concentrations in dogs with CKD justify supplementation has to be evaluated in future studies. PMID:21767966

  16. Experimental infection of equine herpesvirus 9 in dogs.

    PubMed

    Yanai, T; Fujishima, N; Fukushi, H; Hirata, A; Sakai, H; Masegi, T

    2003-05-01

    Equine herpesvirus 9 (EHV-9), a new neurotropic equine herpesvirus, was inoculated intranasally at 107 plaque-forming units in five dogs to assess its pathogenicity. Dogs showed weight loss, pyrexia, anorexia, and neurologic signs on the fourth day. The EHV-9 virus was recovered from the examined brains. Histologically, dogs had a fulminant nonsuppurative encephalitis characterized by severe neuronal degeneration and loss, with intranuclear inclusions, slight glial reactions, perivascular cuffing, and multifocal hemorrhage. The olfactory bulb and the frontal and temporal lobes were predominantly affected. Immunohistochemistry revealed reactivity for EHV-9 antigen in neurons. All dogs had mild bronchopneumonia and various degrees of lymphoid necrosis. These findings indicate that dogs are fully susceptible to EHV-9 and that EHV-9 can cause fulminant encephalitis with high mortality in dogs, as in gazelles and goats. PMID:12724566

  17. Radiotherapy of metastatic seminoma in the dog. Case reports

    SciTech Connect

    McDonald, R.K.; Walker, M.; Legendre, A.M.; vanEe, R.T.; Gompf, R.E.

    1988-04-01

    Four dogs with metastatic seminoma were treated with cesium 137 teleradiotherapy. Minimum total tumor dose ranged from 17 to 40 gray (Gy) and was usually given through bilateral opposing sublumbar ports in eight to ten fractions, with three fractions given weekly. The tumor regressed in all four dogs. The first dog (case 1) was free of tumor and died of non-tumor related causes at 57 months. The second dog (case 2) was free of tumor but was euthanatized at 37 months for a limb fracture. The third dog (case 3) was euthanatized for undertermined pulmonary disease 43 months after radiotherapy. The fourth dog (case 4) was euthanatized 6 months following radiotherapy because of transitional cell carcinoma and renal failure. No evidence of seminoma was found at necropsy. Radiotherapy was shown to be effective treatment for seminoma with regional metastasis.

  18. Survival of Skin Graft between Transgenic Cloned Dogs and Non-Transgenic Cloned Dogs

    PubMed Central

    Kim, Geon A; Oh, Hyun Ju; Kim, Min Jung; Jo, Young Kwang; Choi, Jin; Park, Jung Eun; Park, Eun Jung; Lim, Sang Hyun; Yoon, Byung Il; Kang, Sung Keun; Jang, Goo; Lee, Byeong Chun

    2014-01-01

    Whereas it has been assumed that genetically modified tissues or cells derived from somatic cell nuclear transfer (SCNT) should be accepted by a host of the same species, their immune compatibility has not been extensively explored. To identify acceptance of SCNT-derived cells or tissues, skin grafts were performed between cloned dogs that were identical except for their mitochondrial DNA (mtDNA) haplotypes and foreign gene. We showed here that differences in mtDNA haplotypes and genetic modification did not elicit immune responses in these dogs: 1) skin tissues from genetically-modified cloned dogs were successfully transplanted into genetically-modified cloned dogs with different mtDNA haplotype under three successive grafts over 63 days; and 2) non-transgenic cloned tissues were accepted into transgenic cloned syngeneic recipients with different mtDNA haplotypes and vice versa under two successive grafts over 63 days. In addition, expression of the inserted gene was maintained, being functional without eliciting graft rejection. In conclusion, these results show that transplanting genetically-modified tissues into normal, syngeneic or genetically-modified recipient dogs with different mtDNA haplotypes do not elicit skin graft rejection or affect expression of the inserted gene. Therefore, therapeutically valuable tissue derived from SCNT with genetic modification might be used safely in clinical applications for patients with diseased tissues. PMID:25372489

  19. Characterization of the dog agouti gene and a nonagouti mutation in german shepherd dogs

    SciTech Connect

    Kerns, Julie A.; Newton, J.; Berryere, Tom G.; Rubin, Edward M.; Cheng, Jan-Fang; Schmutz, Sheila M.; Barsh, Gregory S.

    2004-07-08

    The interaction between two genes, Agouti and Melanocortin-1 receptor (Mc1r), produces diverse pigment patterns in mammals by regulating the type, amount, and distribution pattern of the two pigment types found in mammalian hair: eumelanin (brown/black) and pheomelanin (yellow/red). In domestic dogs (Canis familiaris), there is a tremendous variation in coat color patterns between and within breeds; however, previous studies suggest that the molecular genetics of pigment-type switching in dogs may differ from that of other mammals. Here we report the identification and characterization of the Agouti gene from domestic dogs, predicted to encode a 131-amino-acid secreted protein 98 percent identical to the fox homolog, and which maps to chromosome CFA24 in a region of conserved linkage. Comparative analysis of the Doberman Pinscher Agouti cDNA, the fox cDNA, and 180 kb of Doberman Pinscher genomic DNA suggests that, as with laboratory mice, different pigment-type-switching patterns in the canine family are controlled by alternative usage of different promoters and untranslated first exons. A small survey of Labrador Retrievers, Greyhounds, Australian Shepherds, and German Shepherd Dogs did not uncover any polymorphisms, but we identified a single nucleotide variant in black German Shepherd Dogs predicted to cause an Arg-to-Cys substitution at codon 96, which is likely to account for recessive inheritance of a uniform black coat.

  20. FIELD EVALUATION OF A DOG OWNER, PARTICIPATION-BASED, BAIT DELIVERY SYSTEM FOR THE ORAL IMMUNIZATION OF DOGS AGAINST RABIES IN TUNISIA

    Microsoft Academic Search

    SAMIRA BEN YOUSSEF; HANS C. MATTER; CAROLIN L. SCHUMACHER; HABIB KHARMACHI; JEMAA JEMLI; LASSAAD MRABET; MUSTAPHA GHARBI; SALAH HAMMAMI; KHALED EL HICHERI; MICHEL F. A. AUBERT; FRANCOIS X. MESLIN

    1998-01-01

    We evaluated a dog owner, participation-based, bait delivery system for the oral immunization of dogs against rabies. In a field study in a semirural area of northern Tunisia, dog owners were asked to come to temporary bait delivery sites. A total of 314 baits were given to 178 dog owners in four sites. The experimental baits used consisted of a

  1. SOURCE: http://articles.cnn.com/2010-11-18/living/intelligent.dog.psychology_1_dogs-brian-hare-problems?_s=PM:LIVING accessed 12 Nov 2012

    E-print Network

    Packard, Jane M.

    SOURCE: http://articles.cnn.com/2010-11-18/living/intelligent.dog.psychology_1_dogs-brian-hare- problems?_s=PM:LIVING accessed 12 Nov 2012 Inside the science of how dogs think CNN Living: WORLD November toy! Ever wonder what your dog is thinking as it gazes at you while you are barking commands? Duke

  2. All About the Dogs 4-H Weekend -2012 In June, the Rolling Bones 4-H Dog Club of Merrimack county held its fifteenth

    E-print Network

    New Hampshire, University of

    All About the Dogs 4-H Weekend - 2012 In June, the Rolling Bones 4-H Dog Club of Merrimack county held its fifteenth annual All About the Dogs weekend at the 4-H Youth Center in New Boston, NH. This clinic provides a canine training-themed weekend for children enrolled in the 4-H Dog Program

  3. Ancient DNA evidence for Old World origin of New World dogs.

    PubMed

    Leonard, Jennifer A; Wayne, Robert K; Wheeler, Jane; Valadez, Raúl; Guillén, Sonia; Vilŕ, Carles

    2002-11-22

    Mitochondrial DNA sequences isolated from ancient dog remains from Latin America and Alaska showed that native American dogs originated from multiple Old World lineages of dogs that accompanied late Pleistocene humans across the Bering Strait. One clade of dog sequences was unique to the New World, which is consistent with a period of geographic isolation. This unique clade was absent from a large sample of modern dogs, which implies that European colonists systematically discouraged the breeding of native American dogs. PMID:12446908

  4. The Skin Microbiome in Healthy and Allergic Dogs

    PubMed Central

    Rodrigues Hoffmann, Aline; Patterson, Adam P.; Diesel, Alison; Lawhon, Sara D.; Ly, Hoai Jaclyn; Stephenson, Christine Elkins; Mansell, Joanne; Steiner, Jörg M.; Dowd, Scot E.; Olivry, Thierry; Suchodolski, Jan S.

    2014-01-01

    Background Changes in the microbial populations on the skin of animals have traditionally been evaluated using conventional microbiology techniques. The sequencing of bacterial 16S rRNA genes has revealed that the human skin is inhabited by a highly diverse and variable microbiome that had previously not been demonstrated by culture-based methods. The goals of this study were to describe the microbiome inhabiting different areas of the canine skin, and to compare the skin microbiome of healthy and allergic dogs. Methodology/Principal Findings DNA extracted from superficial skin swabs from healthy (n?=?12) and allergic dogs (n?=?6) from different regions of haired skin and mucosal surfaces were used for 454-pyrosequencing of the 16S rRNA gene. Principal coordinates analysis revealed clustering for the different skin sites across all dogs, with some mucosal sites and the perianal regions clustering separately from the haired skin sites. The rarefaction analysis revealed high individual variability between samples collected from healthy dogs and between the different skin sites. Higher species richness and microbial diversity were observed in the samples from haired skin when compared to mucosal surfaces or mucocutaneous junctions. In all examined regions, the most abundant phylum and family identified in the different regions of skin and mucosal surfaces were Proteobacteria and Oxalobacteriaceae. The skin of allergic dogs had lower species richness when compared to the healthy dogs. The allergic dogs had lower proportions of the Betaproteobacteria Ralstonia spp. when compared to the healthy dogs. Conclusions/Significance The study demonstrates that the skin of dogs is inhabited by much more rich and diverse microbial communities than previously thought using culture-based methods. Our sequence data reveal high individual variability between samples collected from different patients. Differences in species richness was also seen between healthy and allergic dogs, with allergic dogs having lower species richness when compared to healthy dogs. PMID:24421875

  5. Treatment of blastomycosis with itraconazole in 112 dogs

    Microsoft Academic Search

    Alfred M. Legendre; Rohrbach Barton W; Robert L. Toal; Michael G. Rinaldi; Linda L. Grace; Janet B. Jones

    1996-01-01

    70 dogs with blastomycosis received 10 mg\\/kg of body weight of itraconazole, daily (group 1), and a second group of 42 dogs received 5 mg\\/kg of itraconazole, daily (group 2). The proportion of dogs cured with a 60-day course of itraconazole was similar for both groups (53.6% in group 1 vs. 54.3% in group 2) and for a control group

  6. Subchronic (13-week) oral toxicity study of ?-cyclodextrin in dogs

    Microsoft Academic Search

    B. A. R Lina; A Bär

    2004-01-01

    The oral toxicity of ?-cyclodextrin (?-CD) was examined in a 13-week feeding study in which groups of Beagle dogs received ?-CD in the diet at concentrations of 0 (control), 5, 10, or 20% (4dogs\\/sex\\/group). No treatment-related changes were noted in behavior or appearance of the dogs and no mortalities occurred. Diarrhea occurred in all ?-CD groups. The incidence and severity

  7. Dogs are able to solve a means-end task

    Microsoft Academic Search

    Friederike Range; Marleen Hentrup; Zsófia Virányi

    2011-01-01

    Dogs, although very skilled in social-communicative tasks, have shown limited abilities in the domain of physical cognition.\\u000a Consequently, several researchers hypothesized that domestication enhanced dogs’ cognitive abilities in the social realm,\\u000a but relaxed selection on the physical one. For instance, dogs failed to demonstrate means-end understanding, an important\\u000a form of relying on physical causal connection, when tested in a string-pulling

  8. A Comparison of Tethering and Pen Confinement of Dogs

    Microsoft Academic Search

    Seong C. Yeon; Glen Golden; Wailani Sung; Hollis N. Erb; Arleigh J. Reynolds; Katherine A. Houpt

    2001-01-01

    This study compared general activity and specific behaviors of 30 adult Alaskan sled dogs, 19 male and 11 female dogs, on 3.5 m tethers and in 5.9 m2 pens. The investiga- tors used activity level and steriotypies as indicators of welfare. The dogs spent most of their time inactive, either lying or sitting both on the tether and in the

  9. Resin hemoperfusion in dogs intoxicated with ethchlorvynol (Placidyl®)

    Microsoft Academic Search

    Michael J Zmuda

    1980-01-01

    Resin hemoperfusion in dogs intoxicated with ethchlorvynol (Placidyl®). Kinetic parameters were studied to determine the effectiveness of hemoperfusion in removing ethchlorvynol from the plasma and red blood cells (RBC) of intoxicated dogs. Perfusion columns contained polystyrene\\/divinyl benzene resin (XAD-4 Amberlite(®)). Column clearances of ethchlorvynol averaged 96.5 ± 0.4% of the plasma flow rate (mean ± SEM, 9 dogs). Plasma ethchlorvynol

  10. Renal parameter estimates in unrestrained dogs

    NASA Technical Reports Server (NTRS)

    Rader, R. D.; Stevens, C. M.

    1974-01-01

    A mathematical formulation has been developed to describe the hemodynamic parameters of a conceptualized kidney model. The model was developed by considering regional pressure drops and regional storage capacities within the renal vasculature. Estimation of renal artery compliance, pre- and postglomerular resistance, and glomerular filtration pressure is feasible by considering mean levels and time derivatives of abdominal aortic pressure and renal artery flow. Changes in the smooth muscle tone of the renal vessels induced by exogenous angiotensin amide, acetylcholine, and by the anaesthetic agent halothane were estimated by use of the model. By employing totally implanted telemetry, the technique was applied on unrestrained dogs to measure renal resistive and compliant parameters while the dogs were being subjected to obedience training, to avoidance reaction, and to unrestrained caging.

  11. Coccidioidomycosis in dogs and cats: a review.

    PubMed

    Graupmann-Kuzma, Angela; Valentine, Beth A; Shubitz, Lisa F; Dial, Sharon M; Watrous, Barbara; Tornquist, Susan J

    2008-01-01

    The dimorphic fungi Coccidioides immitis and Coccidioides posadasii are the causative agents of coccidioidomycosis. Dogs and cats residing in and visiting endemic areas are at risk of exposure to infectious arthrospores. The primary infection is pulmonary and frequently results in chronic cough. Disseminated disease is common and causes cutaneous, osseous, cardiac, ocular, nervous system, or other organ disease. Radiographic changes include a variable degree of interstitial pulmonary infiltration, hilar lymphadenopathy, and osseous lesions. Serological titers support the diagnosis, but definitive diagnosis relies on identification of Coccidioides in cytological or tissue samples. Coccidioidomycosis should be considered in any dog or cat that has been potentially exposed during the previous 3 years and is presented with chronic illness, respiratory signs, lameness, lymphadenopathy, nonhealing cutaneous lesions, or neurological, ocular, or cardiac abnormalities. PMID:18762558

  12. Owned and Unowned Dog Population Estimation, Dog Management and Dog Bites to Inform Rabies Prevention and Response on Lombok Island, Indonesia

    PubMed Central

    Mustiana, Ana; Toribio, Jenny-Ann; Abdurrahman, Muktasam; Suadnya, I. Wayan; Hernandez-Jover, Marta; Putra, Anak Agung Gde; Ward, Michael P.

    2015-01-01

    Although Indonesia has been rabies-infected since at least the 1880s, some islands remain rabies-free, such as Lombok. However, due to its adjacency to rabies-infected islands such as Bali and Flores, there is considerable risk of a rabies incursion. As part of a rabies risk assessment project, surveys were conducted to estimate the size of the dog population and to describe dog management practices of households belonging to different ethnic groups. A photographic-recapture method was employed and the number of unowned dogs was estimated. A total of 400 dog owning households were interviewed, 300 at an urban site and 100 at a rural site. The majority of the interviewed households belonged to the Balinese ethnic group. Owned dogs were more likely male, and non-pedigree or local breed. These households kept their dogs either fully restricted, semi-free roaming or free-roaming but full restriction was reported only at the urban site. Dog bite cases were reported to be higher at the urban site, and commonly affected children/young adults to 20 years old and males. A higher number of unowned dogs was observed at the urban site than at the rural site. Data generated within these surveys can inform rabies risk assessment models to quantify the probability of rabies being released into Lombok and resulting in the infection of the local dog population. The information gained is critical for efforts to educate dog owners about rabies, as a component of preparedness to prevent the establishment of rabies should an incursion occur. PMID:25932916

  13. Acute haemorrhagic diarrhoea syndrome in dogs: 108 cases.

    PubMed

    Mortier, F; Strohmeyer, K; Hartmann, K; Unterer, S

    2015-06-13

    No prospective studies including large numbers of dogs with acute haemorrhagic diarrhoea syndrome (AHDS) are published so far. The aim of this case-control study was to describe signalment, history, clinical signs, laboratory values and course of disease in dogs with AHDS. Dogs (108) with idiopathic acute haemorrhagic diarrhoea (<3?days) were prospectively enrolled. Clinical assessment was performed by calculation of the 'AHDS index' (0-18). The hospital population and 21 healthy dogs served as control groups. Dogs with AHDS had a significantly lower body weight (median 9.8?kg) and age (median five years) than other dogs of the hospital population (20?kg; 10?years) (P<0.001). Predisposed breeds were Yorkshire terrier, miniature pinscher, miniature schnauzer and Maltese. The syndrome was more likely to occur during winter. Vomiting preceded the onset of bloody diarrhoea in 80 per cent of dogs and haematemesis was observed in half of those cases. Median AHDS index at presentation was 12 (range 3-17). Haematocrit was generally high (median 57.1 per cent; range 33-76 per cent), but exceeded 60 per cent only in 31.4 per cent of dogs. Haematocrit of 48.1 per cent of dogs was above reference range, as was monocyte (50.0 per cent), segmented (59.6 per cent) and band neutrophil count (45.2 per cent). A rapid clinical improvement occurred during the first 48?hours. PMID:26023146

  14. Radiofrequency catheter ablation of atypical atrial flutter in dogs.

    PubMed

    Santilli, Roberto A; Ramera, Lucia; Perego, Manuela; Moretti, Paolo; Spadacini, Giammario

    2014-03-01

    Five dogs were presented to our institution for fatigue caused by an incessant supraventricular tachycardia. In all dogs, an ECG on admission showed a narrow QRS complex tachycardia with a median ventricular cycle length of 220 ms (range 180-360 ms), and a positive atrial depolarization identifiable in the ST segment following the previous QRS complex. There was a 1:1 atrioventricular conduction ratio in all but one dog, which presented with 2:1 atrioventricular block. Electrophysiologic studies identified the underlying arrhythmogenic mechanism as a right atrial macro-reentrant tachycardia with two distinct isthmic areas: right septal (RS) in three dogs and right atrial free wall (RAFW) in two dogs. Linear radiofrequency catheter ablation was performed during tachycardia in all dogs at the identified isthmic area, which acutely blocked the macroreentrant circuit. At 18-month follow-up, 3 dogs (1 with RAFW isthmus and 2 with RS isthmus) showed no recurrence of the arrhythmia on Holter monitoring. One dog with RS isthmus showed recurrence of the supraventricular tachycardia 15 days post-ablation, and 1 dog with RAFW isthmus presented with persistent atrial fibrillation 2 months post-ablation. PMID:24461642

  15. Computed tomographic diagnosis of nongastrointestinal foreign bodies in dogs.

    PubMed

    Jones, Jeryl C; Ober, Christopher P

    2007-01-01

    Clinical data and computed tomography (CT) studies were reviewed for 13 dogs with confirmed nongastrointestinal foreign bodies. Locations of foreign bodies were the nasal cavity, thoracic wall, retropharyngeal region, and cerebellum. Types of foreign bodies included small plant components, blades of grass, wooden sticks, cloth fibers, and a needle. Foreign bodies in five dogs were not identified on CT, and secondary reactions resembled neoplastic or fungal disease. In eight dogs, foreign bodies were recognized by their shape and/or internal architecture. In two dogs, three-dimensional reformatting helped demonstrate foreign bodies in relation to palpable bony landmarks. PMID:17339287

  16. Testing the myth: tolerant dogs and aggressive wolves

    PubMed Central

    Range, Friederike; Ritter, Caroline; Virányi, Zsófia

    2015-01-01

    Cooperation is thought to be highly dependent on tolerance. For example, it has been suggested that dog–human cooperation has been enabled by selecting dogs for increased tolerance and reduced aggression during the course of domestication (‘emotional reactivity hypothesis’). However, based on observations of social interactions among members of captive packs, a few dog–wolf comparisons found contradictory results. In this study, we compared intraspecies aggression and tolerance of dogs and wolves raised and kept under identical conditions by investigating their agonistic behaviours and cofeeding during pair-wise food competition tests, a situation that has been directly linked to cooperation. We found that in wolves, dominant and subordinate members of the dyads monopolized the food and showed agonistic behaviours to a similar extent, whereas in dogs these behaviours were privileges of the high-ranking individuals. The fact that subordinate dogs rarely challenged their higher-ranking partners suggests a steeper dominance hierarchy in dogs than in wolves. Finally, wolves as well as dogs showed only rare and weak aggression towards each other. Therefore, we suggest that wolves are sufficiently tolerant to enable wolf–wolf cooperation, which in turn might have been the basis for the evolution of dog–human cooperation (canine cooperation hypothesis). PMID:25904666

  17. Whole genome comparison of donor and cloned dogs

    PubMed Central

    Kim, Hak-Min; Cho, Yun Sung; Kim, Hyunmin; Jho, Sungwoong; Son, Bongjun; Choi, Joung Yoon; Kim, Sangsoo; Lee, Byeong Chun; Bhak, Jong; Jang, Goo

    2013-01-01

    Cloning is a process that produces genetically identical organisms. However, the genomic degree of genetic resemblance in clones needs to be determined. In this report, the genomes of a cloned dog and its donor were compared. Compared with a human monozygotic twin, the genome of the cloned dog showed little difference from the genome of the nuclear donor dog in terms of single nucleotide variations, chromosomal instability, and telomere lengths. These findings suggest that cloning by somatic cell nuclear transfer produced an almost identical genome. The whole genome sequence data of donor and cloned dogs can provide a resource for further investigations on epigenetic contributions in phenotypic differences. PMID:24141358

  18. HUNT STABLE COMPLEX LOOKING NORTHWEST TOWARD DOG KENNEL RUINS ACROSS ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    HUNT STABLE COMPLEX LOOKING NORTHWEST TOWARD DOG KENNEL RUINS ACROSS THE GREAT CIRCUS - Overhills, Fort Bragg Military Reservation, Approximately 15 miles NW of Fayetteville, Overhills, Harnett County, NC

  19. Wolves Are Better Imitators of Conspecifics than Dogs

    PubMed Central

    Range, Friederike; Virányi, Zsófia

    2014-01-01

    Domestication is thought to have influenced the cognitive abilities of dogs underlying their communication with humans, but little is known about its effect on their interactions with conspecifics. Since domestication hypotheses offer limited predictions in regard to wolf-wolf compared to dog-dog interactions, we extend the cooperative breeding hypothesis suggesting that the dependency of wolves on close cooperation with conspecifics, including breeding but also territory defense and hunting, has created selection pressures on motivational and cognitive processes enhancing their propensity to pay close attention to conspecifics’ actions. During domestication, dogs’ dependency on conspecifics has been relaxed, leading to reduced motivational and cognitive abilities to interact with conspecifics. Here we show that 6-month-old wolves outperform same aged dogs in a two-action-imitation task following a conspecific demonstration. While the wolves readily opened the apparatus after a demonstration, the dogs failed to solve the problem. This difference could not be explained by differential motivation, better physical insight of wolves, differential developmental pathways of wolves and dogs or a higher dependency of dogs from humans. Our results are best explained by the hypothesis that higher cooperativeness may come together with a higher propensity to pay close attention to detailed actions of others and offer an alternative perspective to domestication by emphasizing the cooperativeness of wolves as a potential source of dog-human cooperation. PMID:24489744

  20. Serum paraoxonase 1 and butyrylcholinesterase in dogs with hyperadrenocorticism.

    PubMed

    Tvarijonaviciute, Asta; Caldin, Marco; Martinez-Subiela, Silvia; Tecles, Fernando; Pastor, Josep; Ceron, Jose J

    2015-02-01

    The aim of this study was to evaluate serum activities of paraoxonase 1 (PON1) using three substrates; (1) 4-nitrophenylacetate (PON1n), (2) phenylacetate (PON1p), and (3) 5-thiobutyl butyrolactonase (PON1t), and butyrylcholinesterase (BChE) in dogs with hyperadrenocorticism (HAC). Serum activities of PON1 and BChE were higher in dogs with HAC than healthy dogs. There were strong positive correlations between PON1 activity measured with the three different substrates. This study demonstrated increased serum PON1 and BChE activities in dogs with HAC that could be attributed to the direct effect of glucocorticoids and lipid mobilisation. PMID:25555340