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1

Neonatal retroviral vector-mediated hepatic gene therapy reduces bone, joint, and cartilage disease in mucopolysaccharidosis VII mice and dogs  

Microsoft Academic Search

Mucopolysaccharidosis VII (MPS VII) is a lysosomal storage disease caused by deficient ?-glucuronidase (GUSB) activity. Accumulation of glycosaminoglycans (GAGs) in bone, cartilage, and synovium likely contributes to reduced mobility in untreated MPS VII individuals. We previously reported that neonatal intravenous injection of a retroviral vector (RV) expressing canine GUSB resulted in hepatocyte transduction in mice and dogs, and secreted GUSB

Robert L. Mango; Lingfei Xu; Mark S. Sands; Carole Vogler; Gabriela Seiler; Tobias Schwarz; Mark E. Haskins; Katherine Parker Pondera

2004-01-01

2

Radiographic characterization of presumed plate-like atelectasis in 75 nonanesthetized dogs and 15 cats.  

PubMed

Discrete discoid or linear areas of increased soft opacity have been observed within the pulmonary parenchyma in thoracic radiographs of dogs and cats. Similar radiographic findings have been described in humans and termed plate-like atelectasis. The purpose of this retrospective study was to describe locations and characteristics of presumed plate-like atelectasis, presence of concurrent thoracic disease(s), and presence of persistent pulmonary changes on recheck thoracic radiographic studies in a cohort of dogs and cats. Hospital records between 2004 and 2011 were searched and a total of 90 cases were included (75 dogs and 15 cats, 2-17 years of age). Plate-like atelectasis was most commonly found in left lateral radiographs. Plate-like atelectasis was observed in the cranial thorax and was oriented in a dorsocranial to ventrocaudal direction in 68 (75%) patients. Plate-like atelectasis averaged 29.6 ± 14.4 mm in length and 2.6 ± 1.3 mm in width. In 57 of the 90 patients (63%), plate-like atelectasis was the only abnormality found. Plate-like atelectasis was present in 7 of 22 cases where follow-up radiographs were available. Findings from the current study indicated that, while the etiology of plate-like atelectasis remains unknown, anatomic variations in sublobar pulmonary anatomy might account for pleural areas of atelectasis. The authors propose that the presence of plate-like atelectasis may represent areas of atelectasis that track along sublobar lung lobe separations, an area of hypoventilation or decreased collateral ventilation, and/or area of decreased localized surfactant deficiency. PMID:23551337

Giglio, Robson F; Winter, Matthew D; Reese, David J; Thrall, Donald E; Abbott, Jeffrey R; Graham, John P; Berry, Clifford R

2013-01-01

3

Dogs  

MedlinePLUS

... their stool, and their food. By providing your pet with routine veterinary care and some simple health tips, you are less ... feces and possible spread of disease. Monitor your pet's health ... a veterinarian for routine evaluation and care to keep your dog healthy and prevent infectious ...

4

Imaging herpes simplex virus type 1 amplicon vector-mediated gene expression in human glioma spheroids.  

PubMed

Vectors derived from herpes simplex virus type 1 (HSV-1) have great potential for transducing therapeutic genes into the central nervous system; however, inefficient distribution of vector particles in vivo may limit their therapeutic potential in patients with gliomas. This study was performed to investigate the extent of HSV-1 amplicon vector-mediated gene expression in a three-dimensional glioma model of multicellular spheroids by imaging highly infectious HSV-1 virions expressing green fluorescent protein (HSV-GFP). After infection or microscopy-guided vector injection of glioma spheroids at various spheroid sizes, injection pressures and injection times, the extent of HSV-1 vector-mediated gene expression was investigated via laser scanning microscopy. Infection of spheroids with HSV-GFP demonstrated a maximal depth of vector-mediated GFP expression at 70 to 80 ?m. A > 80% transduction efficiency was reached only in small spheroids with a diameter of < 150 ?m. Guided vector injection into the spheroids showed transduction efficiencies ranging between < 10 and > 90%. The results demonstrated that vector-mediated gene expression in glioma spheroids was strongly dependent on the mode of vector application-injection pressure and injection time being the most important parameters. The assessment of these vector application parameters in tissue models will contribute to the development of safe and efficient gene therapy protocols for clinical application. PMID:21443839

Kaestle, Christine; Winkeler, Alexandra; Richter, Raphaela; Sauer, Heinrich; Hescheler, Jürgen; Fraefel, Cornel; Wartenberg, Maria; Jacobs, Andreas H

2011-06-01

5

Presumed Aggregatibacter aphrophilus endogenous endophthalmitis.  

PubMed

We hereby report a case of endogenous endophthalmitis, presumably caused by a rare culprit-Aggregatibacter aphrophilus. A. aphrophilus is a member of the HACEK group, a group of fastidious Gram-negative bacteria with low pathogenicity and a rare cause of human infections. For ophthalmic infection, it has been reported to cause canaliculitis and exogenous endophthalmitis. A middle-aged gentleman with good past health presented with decreased vision (20/200) in his left eye. Other than fever, he was well on presentation, with no apparent focus of infection. Subsequently, he developed an episode of high fever reaching 39.2 °C, with CRP of 233 mg/L. CT abdomen showed presumed kidney abscess and a rare Gram-negative coccobacillus. A. aphrophilus [formerly Haemophilus aphrophilus (Nřrskov-lauritsen and Kilian in Int J Syst Evol Microbiol 56:2135-2146, 2006)] was found in blood culture, Vitreous sample was analysed using 16S ribosomal DNA amplification but failed to identify the organism. After appropriate treatment, his vision improved drastically from 20/200 to 20/30. A. aphrophilus isolated from blood cultures during septicemia in a patient with kidney abscess may be associated with metastatic endophthalmitis, which may appear as a first sign. Our case demonstrates that with prompt diagnosis and appropriate treatment, visual prognosis of A. aphrophilus endophthalmitis can be promising. PMID:25680418

Shum, Jennifer W H; Tsang, Felix C W; Fung, Kitty S C; Li, Kenneth K W

2015-04-01

6

Characterising dark matter searches at colliders and direct detection experiments: vector mediators  

NASA Astrophysics Data System (ADS)

We introduce a Minimal Simplified Dark Matter (MSDM) framework to quantitatively characterise dark matter (DM) searches at the LHC. We study two MSDM models where the DM is a Dirac fermion which interacts with a vector and axial-vector mediator. The models are characterised by four parameters: m DM , M med , g DM and g q, the DM and mediator masses, and the mediator couplings to DM and quarks respectively. The MSDM models accurately capture the full event kinematics, and the dependence on all masses and couplings can be systematically studied. The interpretation of mono-jet searches in this framework can be used to establish an equal-footing comparison with direct detection experiments. For theories with a vector mediator, LHC mono-jet searches possess better sensitivity than direct detection searches for light DM masses (?5 GeV). For axial-vector mediators, LHC and direct detection searches generally probe orthogonal directions in the parameter space. We explore the projected limits of these searches from the ultimate reach of the LHC and multi-ton xenon direct detection experiments, and find that the complementarity of the searches remains. Finally, we provide a comparison of limits in the MSDM and effective field theory (EFT) frameworks to highlight the deficiencies of the EFT framework, particularly when exploring the complementarity of mono-jet and direct detection searches.

Buchmueller, Oliver; Dolan, Matthew J.; Malik, Sarah A.; McCabe, Christopher

2015-01-01

7

Nacystelyn enhances adenoviral vector-mediated gene delivery to mouse airways.  

PubMed

Adenoviral vector-mediated gene delivery has been vastly investigated for cystic fibrosis (CF) gene therapy; however, one of its drawbacks is the low efficiency of gene transfer, which is due to basolateral colocalization of viral receptors, immune responses to viral vectors and the presence of a thick mucus layer in the airways of CF patients. Therefore, enhancement of gene transfer can lead to reduction in the viral dosage, which could further reduce the acute toxicity associated with the use of adenoviral vectors. Nacystelyn (NAL) is a mucolytic agent with anti-inflammatory and antioxidant properties, and has been used clinically in CF patients to reduce mucus viscosity in the airways. In this study, we show that pretreatment of the airways with NAL followed by administration of adenoviral vectors in complex with DEAE-Dextran can significantly enhance gene delivery to the airways of mice without any harmful effects. Moreover, NAL pretreatment can reduce the airway inflammation, which is normally observed after delivery of adenoviral particles. Taken together, these results indicate that NAL pretreatment followed by adenoviral vector-mediated gene delivery can be beneficial to CF patients by increasing the efficiency of gene transfer to the airways, and reducing the acute toxicity associated with the administration of adenoviral vectors. PMID:17525704

Kushwah, R; Oliver, J R; Cao, H; Hu, J

2007-08-01

8

Lentiviral Vector-Mediated RNA Silencing in the Central Nervous System  

PubMed Central

Abstract RNA silencing is an established method for investigating gene function and has attracted particular interest because of the potential for generating RNA-based therapeutics. Using lentiviral vectors as an efficient delivery system that offers stable, long-term expression in postmitotic cells further enhances the applicability of an RNA-based gene therapy for the CNS. In this review we provide an overview of both lentiviral vectors and RNA silencing along with design considerations for generating lentiviral vectors capable of RNA silencing. We go on to describe the current preclinical data regarding lentiviral vector-mediated RNA silencing for CNS disorders and discuss the concerns of side effects associated with lentiviral vectors and small interfering RNAs and how these might be mitigated. PMID:24090197

Foster, Edmund; Moon, Lawrence D.F.

2014-01-01

9

Apparent vector-mediated parent-to-offspring transmission in an avian malaria-like parasite.  

PubMed

Parasite transmission strategies strongly impact host-parasite co-evolution and virulence. However, studies of vector-borne parasites such as avian malaria have neglected the potential effects of host relatedness on the exchange of parasites. To test whether extended parental care in the presence of vectors increases the probability of transmission from parents to offspring, we used high-throughput sequencing to develop microsatellites for malaria-like Leucocytozoon parasites of a wild raptor population. We show that host siblings carry genetically more similar parasites than unrelated chicks both within and across years. Moreover, chicks of mothers of the same plumage morph carried more similar parasites than nestlings whose mothers were of different morphs, consistent with matrilineal transmission of morph-specific parasite strains. Ours is the first evidence of an association between host relatedness and parasite genetic similarity, consistent with vector-mediated parent-to-offspring transmission. The conditions for such 'quasi-vertical' transmission may be common and could suppress the evolution of pathogen virulence. PMID:25688585

Chakarov, Nayden; Linke, Burkhard; Boerner, Martina; Goesmann, Alexander; Krüger, Oliver; Hoffman, Joseph I

2015-03-01

10

Effects of Herpes Simplex Virus Vector–Mediated Enkephalin Gene Therapy on Bladder Overactivity and Nociception  

PubMed Central

Abstract We previously reported the effects of herpes simplex virus (HSV) vector–mediated enkephalin on bladder overactivity and pain. In this study, we evaluated the effects of vHPPE (E1G6-ENK), a newly engineered replication-deficient HSV vector encoding human preproenkephalin (hPPE). vHPPE or control vector was injected into the bladder wall of female rats 2 weeks prior to the following studies. A reverse-transcription PCR study showed high hPPE transgene levels in L6 dorsal root ganglia innervating the bladder in the vHPPE group. The number of freezing behaviors, which is a nociceptive reaction associated with bladder pain, was also significantly lower in the vHPPE group compared with the control group. The number of L6 spinal cord c-fos–positive cells and the urinary interleukin (IL)-1? and IL-6 levels after resiniferatoxin (RTx) administration into the bladder of the vHPPE group were significantly lower compared with those of the control vector–injected group. In continuous cystometry, the vHPPE group showed a smaller reduction in intercontraction interval after RTx administration into the bladder. This antinociceptive effect was antagonized by naloxone hydrochloride. Thus, the HSV vector vHPPE encoding hPPE demonstrated physiological improvement in visceral pain induced by bladder irritation. Gene therapy may represent a potentially useful treatment modality for bladder hypersensitive disorders such as bladder pain syndrome/interstitial cystitis. PMID:23316929

Yokoyama, Hitoshi; Oguchi, Tomohiko; Goins, William F.; Goss, James R.; Nishizawa, Osamu; de Groat, William C.; Wolfe, Darren; Krisky, David M.; Glorioso, Joseph C.

2013-01-01

11

[Epidemiology of presumed benign ovarian tumors].  

PubMed

Ovarian cysts presumed benign can be organic or functional. Their prevalence is estimated between 14 and 18% in postmenopausal women and around 7% in asymptomatic women of childbearing age. Their incidence during pregnancy is between 0.2 and 5% and varies within the term of pregnancy. Ovarian cysts presumed benign have caused nearly 45,000 hospitalizations in France in 2012, bringing the annual risk of hospitalization for a woman residing in France to 1.3‰. Among the risk factors studied in the literature, tamoxifen increases the incidence of ovarian cysts in premenopausal patients and immunosuppressive treatments are associated with a high prevalence of benign ovarian cysts while estrogen contraception reduces the risk of developing functional cysts. PMID:24210235

Mimoun, C; Fritel, X; Fauconnier, A; Deffieux, X; Dumont, A; Huchon, C

2013-12-01

12

Presumed primary intraocular chondrosarcoma in cats.  

PubMed

Following unilateral enucleation, 4 Domestic Shorthair cats with an average age of 12.5 years (range: 9-16 years) were histologically diagnosed with a presumed primary intraocular chondrosarcoma at the Comparative Ocular Pathology Laboratory of Wisconsin (Madison, Wisconsin). Medical records and follow-up were available for 3 of the 4 cats. Clinically, only 1 eye was affected in each cat; a mass lesion was noted in 2 cats, and a neoplasm was suspected in the other 2 cats. Grossly, 3 tumors presented as coalescing, poorly demarcated, white, friable masses filling the vitreous and intraocular chambers; 1 tumor presented as a solitary, well-demarcated, tan mass involving the iris and ciliary body. Histologically, all 4 neoplasms were composed of haphazardly arranged plump neoplastic spindle cells surrounded by irregular islands and thick trabeculae of abundant, variably basophilic, and Alcian blue-positive chondromatous matrix. None of the cats presented histologically or clinically with signs suggestive of feline posttraumatic ocular sarcoma. Two cats are still alive and healthy 6 months and 3 years following enucleation. One cat died 6 months following enucleation; however, this cat suffered from poorly controlled diabetes mellitus, and the cause of death is undetermined. No other tumors or skeletal lesions were identified that could suggest a metastatic tumor to the eye. The origin of primary intraocular chondrosarcoma is unclear, but is presumed to be ocular multipotent mesenchymal stem cells. Four cases of intraocular chondrosarcoma in cats not associated with the posttraumatic sarcoma complex of intraocular tumors are described. PMID:25057162

Beckwith-Cohen, Billie; Teixeira, Leandro B C; Dubielzig, Richard R

2014-09-01

13

Polyorchidism with presumed contralateral intrauterine testicular torsion  

PubMed Central

INTRODUCTION Polyorchidism was first described by Blasius in 16701 during a routine autopsy. We report a child with unilateral polyorchidism and a contralateral absent testis, a combination not reported previously. PRESENTATION OF CASE A 2-year-old boy was referred to the outpatient clinic with an impalpable left testis. At laparoscopy, the left vas deferens and testicular vessels ended blindly proximal to a closed internal ring. No gonadal tissue was identified. On the right side, a single vas deferens and testicular vessels were seen entering the internal ring as normal. The right side of the scrotum was explored and two testes were identified within a single tunica vaginalis. DISCUSSION Polyorchidism is rare with a literature search identifying approximately 230 reported cases. Whilst prenatal testicular torsion is increasing being recognized and treated as a surgical emergency,9 prenatal testicular torsion in association with polyorchidism has not been previously reported. CONCLUSION We describe a unique case of a 2-year-old boy with right-sided polyorchidism and an absent left testis associated with a blind ending vas deferens and testicular vessels, presumed secondary to intrauterine testicular torsion. PMID:25462053

Leodoro, B.M.; Beasley, S.W.; Stringer, M.D.

2014-01-01

14

Colorblind Dogs  

NSDL National Science Digital Library

This activity (on page 2 of the PDF) is a full inquiry investigation into dogs' ability (or inability) to see color. Learners conduct an experiment by first performing a control test and then experimenting to see if dogs are able to fetch colored balls amid a background of gray balls. Learners collect, record, and graph the data to draw conclusions about colorblindness in dogs. Relates to linked video, DragonflyTV: Colorblind Dogs.

Twin Cities Public Television, Inc.

2005-01-01

15

Prairie Dog  

USGS Multimedia Gallery

A prairie dog stands on alert. The USGS National Wildlife Health Center works to identify, track, and prevent wildlife disease. Better protection of prairie dogs against plague would minimize the risk of disease transfer to endangered black-footed ferrets, aid in prairie dog conservation, and protec...

16

20 CFR 219.24 - Evidence of presumed death.  

Code of Federal Regulations, 2013 CFR

... 2012-04-01 true Evidence of presumed death. 219.24 Section 219.24 Employees...EVIDENCE REQUIRED FOR PAYMENT Evidence of Age and Death § 219.24 Evidence of presumed death. When a person cannot be proven dead but...

2013-04-01

17

20 CFR 219.24 - Evidence of presumed death.  

Code of Federal Regulations, 2014 CFR

... 2012-04-01 true Evidence of presumed death. 219.24 Section 219.24 Employees...EVIDENCE REQUIRED FOR PAYMENT Evidence of Age and Death § 219.24 Evidence of presumed death. When a person cannot be proven dead but...

2014-04-01

18

20 CFR 219.24 - Evidence of presumed death.  

Code of Federal Regulations, 2012 CFR

...2012-04-01 false Evidence of presumed death. 219.24 Section 219.24 Employees...EVIDENCE REQUIRED FOR PAYMENT Evidence of Age and Death § 219.24 Evidence of presumed death. When a person cannot be proven dead but...

2012-04-01

19

20 CFR 219.24 - Evidence of presumed death.  

Code of Federal Regulations, 2011 CFR

...2011-04-01 false Evidence of presumed death. 219.24 Section 219.24 Employees...EVIDENCE REQUIRED FOR PAYMENT Evidence of Age and Death § 219.24 Evidence of presumed death. When a person cannot be proven dead but...

2011-04-01

20

Functional metastatic parathyroid adenocarcinoma in a dog  

PubMed Central

A 12-year-old dachshund dog was presented for persistent hypercalcemia and hyperparathyroidism despite bilateral parathyroidectomy. Magnetic resonance imaging of the head, neck, and cranial mediastinum identified an increased number of cranial mediastinal lymph nodes with heterogeneous signal intensity. Hypercalcemia and hyperparathyroidism resolved after surgery to remove multiple cranial mediastinal lymph nodes, one of which contained presumed metastatic parathyroid tissue. PMID:24688141

Kishi, Erin N.; Holmes, Shannon P.; Abbott, Jeffrey R.; Bacon, Nicholas J.

2014-01-01

21

Dog Whisperer  

E-print Network

to star in a Chinese TV show called "Leader of the Pack." Mr. Millan, as you might know, is famous for being the Dog Whisperer. His training programs and TV show have made him a household name among dog owners. His approach is all about exercise...

Hacker, Randi

2013-05-22

22

Exponential enhancement of oncolytic vesicular stomatitis virus potency by vector-mediated suppression of inflammatory responses in vivo.  

PubMed

Oncolytic virotherapy is a promising strategy for treatment of malignancy, although its effectiveness is hampered by host antiviral inflammatory responses. The efficacy of treatment of oncolytic vesicular stomatitis virus (VSV) in rats bearing multifocal hepatocellular carcinoma (HCC) can be substantially elevated by antibody-mediated depletion of natural killer (NK) cells. In order to test the hypothesis that the oncotyic potency of VSV can be exponentially elevated by evasion of inflammatory responses in vivo, we constructed a recombinant VSV vector expressing equine herpes virus-1 glycoprotein G, which is a broad-spectrum viral chemokine binding protein (rVSV-gG). Infusion of rVSV-gG via the hepatic artery into immune-competent rats bearing syngeneic and multifocal HCC in their livers, resulted in a reduction of NK and NKT cells in the tumors and a 1-log enhancement in intratumoral virus titer in comparison with a reference rVSV vector. The treatment led to increased tumor necrosis and substantially prolonged animal survival without toxicities. These results indicate that rVSV-gG has the potential to be developed as an effective and safe oncolytic agent to treat patients with advanced HCC. Furthermore, the novel concept that oncolytic potency can be substantially enhanced by vector-mediated suppression of host antiviral inflammatory responses could have general applicability in the field of oncolytic virotherapy for cancer. PMID:18071337

Altomonte, Jennifer; Wu, Lan; Chen, Li; Meseck, Marcia; Ebert, Oliver; García-Sastre, Adolfo; Fallon, John; Woo, Savio L C

2008-01-01

23

20 CFR 219.24 - Evidence of presumed death.  

Code of Federal Regulations, 2010 CFR

...date the person disappeared. (c) When a person has been missing for less than 7 years but may be presumed dead due to drowning or common disaster (fire, accident, etc.), signed statements from the applicant and individuals who know the...

2010-04-01

24

West end of rail yard where dump area presumably stood. ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

West end of rail yard where dump area presumably stood. Foundation wall and pipes in foreground. Wood foundation in background with railroad tracks beyond. - Grand Canyon Village Utilities, Grand Canyon National Park, Grand Canyon Village, Coconino County, AZ

25

Preclinical demonstration of lentiviral vector-mediated correction of immunological and metabolic abnormalities in models of adenosine deaminase deficiency.  

PubMed

Gene transfer into autologous hematopoietic stem cells by ?-retroviral vectors (gRV) is an effective treatment for adenosine deaminase (ADA)-deficient severe combined immunodeficiency (SCID). However, current gRV have significant potential for insertional mutagenesis as reported in clinical trials for other primary immunodeficiencies. To improve the efficacy and safety of ADA-SCID gene therapy (GT), we generated a self-inactivating lentiviral vector (LV) with a codon-optimized human cADA gene under the control of the short form elongation factor-1? promoter (LV EFS ADA). In ADA(-/-) mice, LV EFS ADA displayed high-efficiency gene transfer and sufficient ADA expression to rescue ADA(-/-) mice from their lethal phenotype with good thymic and peripheral T- and B-cell reconstitution. Human ADA-deficient CD34(+) cells transduced with 1-5?×?10(7) TU/ml had 1-3 vector copies/cell and expressed 1-2x of normal endogenous levels of ADA, as assayed in vitro and by transplantation into immune-deficient mice. Importantly, in vitro immortalization assays demonstrated that LV EFS ADA had significantly less transformation potential compared to gRV vectors, and vector integration-site analysis by nrLAM-PCR of transduced human cells grown in immune-deficient mice showed no evidence of clonal skewing. These data demonstrated that the LV EFS ADA vector can effectively transfer the human ADA cDNA and promote immune and metabolic recovery, while reducing the potential for vector-mediated insertional mutagenesis. PMID:24256635

Carbonaro, Denise A; Zhang, Lin; Jin, Xiangyang; Montiel-Equihua, Claudia; Geiger, Sabine; Carmo, Marlene; Cooper, Aaron; Fairbanks, Lynette; Kaufman, Michael L; Sebire, Neil J; Hollis, Roger P; Blundell, Michael P; Senadheera, Shantha; Fu, Pei-Yu; Sahaghian, Arineh; Chan, Rebecca Y; Wang, Xiaoyan; Cornetta, Kenneth; Thrasher, Adrian J; Kohn, Donald B; Gaspar, H Bobby

2014-03-01

26

Preclinical Demonstration of Lentiviral Vector-mediated Correction of Immunological and Metabolic Abnormalities in Models of Adenosine Deaminase Deficiency  

PubMed Central

Gene transfer into autologous hematopoietic stem cells by ?-retroviral vectors (gRV) is an effective treatment for adenosine deaminase (ADA)–deficient severe combined immunodeficiency (SCID). However, current gRV have significant potential for insertional mutagenesis as reported in clinical trials for other primary immunodeficiencies. To improve the efficacy and safety of ADA-SCID gene therapy (GT), we generated a self-inactivating lentiviral vector (LV) with a codon-optimized human cADA gene under the control of the short form elongation factor-1? promoter (LV EFS ADA). In ADA?/? mice, LV EFS ADA displayed high-efficiency gene transfer and sufficient ADA expression to rescue ADA?/? mice from their lethal phenotype with good thymic and peripheral T- and B-cell reconstitution. Human ADA-deficient CD34+ cells transduced with 1–5?×?107 TU/ml had 1–3 vector copies/cell and expressed 1–2x of normal endogenous levels of ADA, as assayed in vitro and by transplantation into immune-deficient mice. Importantly, in vitro immortalization assays demonstrated that LV EFS ADA had significantly less transformation potential compared to gRV vectors, and vector integration-site analysis by nrLAM-PCR of transduced human cells grown in immune-deficient mice showed no evidence of clonal skewing. These data demonstrated that the LV EFS ADA vector can effectively transfer the human ADA cDNA and promote immune and metabolic recovery, while reducing the potential for vector-mediated insertional mutagenesis. PMID:24256635

Carbonaro, Denise A; Zhang, Lin; Jin, Xiangyang; Montiel-Equihua, Claudia; Geiger, Sabine; Carmo, Marlene; Cooper, Aaron; Fairbanks, Lynette; Kaufman, Michael L; Sebire, Neil J; Hollis, Roger P; Blundell, Michael P; Senadheera, Shantha; Fu, Pei-Yu; Sahaghian, Arineh; Chan, Rebecca Y; Wang, Xiaoyan; Cornetta, Kenneth; Thrasher, Adrian J; Kohn, Donald B; Gaspar, H Bobby

2014-01-01

27

Dog Bite Prevention  

MedlinePLUS

... records. Consult with your veterinarian about your dog’s aggressive action. Your veterinarian can examine your dog to ... or one they know. Some owners actually promote aggression in their dogs or allow aggression to go ...

28

Ultrasonographic features of uterus masculinus in six dogs.  

PubMed

Uterus masculinus (persistent Mullerian duct) is a vestigial embryological remnant of the paramesonephric duct system in males and has been associated with clinical signs such as dysuria, incontinence, tenesmus and urethral obstruction in dogs. The radiological appearance of cystic uterus masculinus in dogs has been described previously with the aid of retrograde positive or negative contrast cystography. The purpose of this retrospective study was to describe ultrasonographic features of confirmed or presumed uterus masculinus in a group of dogs with confirmed or presumed disease. Ultrasonographic findings were recorded based on a consensus opinion of two readers. A uterus masculinus was defined as cylindrical when no lumen was observed and tubular when it had lumen that was filled with anechoic fluid. Six dogs met the inclusion criterion with a mean age of 8 years and 9 months. Uterus masculinus appeared as single (four dogs) or two (two dogs) horn-like, tubular (four dogs) or cylindrical (two dogs) structures, originating from the craniodorsal aspect of the prostate gland and extending cranially. The walls of the uterus masculinus were isoechoic to the urinary bladder wall. The diameter of the observed uterus masculinus varied from 0.3 cm to 1 cm. The length of the uterus masculinus varied from 2 cm to 6.5 cm but the cranial terminal end was not identified in two dogs. Concomitant prostatomegaly was seen in five dogs (83.3%) and urinary tract infection was noted in three dogs (50%). Findings indicated that uterus masculinus should be included as a differential diagnosis for male dogs with these ultrasonographic characteristics. PMID:25074324

Lim, Chee Kin; Heng, Hock Gan; Hui, Timothy Y; Thompson, Craig A; Childress, Michael O; Adams, Larry G

2015-01-01

29

CASE REPORTS Cervicogenic Headache in Patients With Presumed Migraine  

E-print Network

CASE REPORTS Cervicogenic Headache in Patients With Presumed Migraine: Missed Diagnosis challenge. Four female patients, ages 26 to 69 with standing diagnoses of migraine, were evaluated and treated for complaints of chronic, severe headaches. All had obtained limited relief from migraine

Steinbach, Joe Henry

30

Normative consent and presumed consent for organ donation: a critique  

Microsoft Academic Search

Ben Saunders claims that actual consent is not necessary for organ donation due to ‘normative consent’, a concept he borrows from David Estlund. Combining normative consent with Peter Singer's ‘greater moral evil principle’, Saunders argues that it is immoral for an individual to refuse consent to donate his or her organs. If a presumed consent policy were thus adopted, it

Michael Potts; Joseph L Verheijde; Mohamed Y Rady; David W Evans

2010-01-01

31

Renal clearance studies of effect of left atrial distension in the dog.  

NASA Technical Reports Server (NTRS)

Investigation of the water diuresis of left atrial distension in 16 dogs on the basis of clearance studies employing hydration, chronic and acute salt loading, deoxycorticosterone (DOCA) in excess, and distal tubular nephron blockade with diuretics. The diuresis was found in hydrated and salt-loaded dogs and was independent of DOCA and presumed renin depletion. It was not found in five dogs after distal tubular blockade. No significant reproducible saluresis was ever documented. The water diuresis was always stopped by exogenous vasopressin (seven dogs). Antidiuretic hormone inhibition with distal tubular nephron water permeability changes appears to be the sole mechanism of the diuresis of left atrial distension in the dog.

Kinney, M. J.; Discala, V. A.

1972-01-01

32

Dog Breeds  

NSDL National Science Digital Library

Recently, designer mutts like the Labradoodle -- a cross between a Labarador retriever and a poodle -- have become popular. A listener wanted to know if some kinds of dogs are just too different to make puppies. This Science Update explores the cross breeding of species.

2004-07-05

33

Dog Breeding  

NSDL National Science Digital Library

This online Flash game gets learners thinking like geneticists in order to breed a border collie puppy with select traits, including coat color, coat length, and ear length. Progressive levels of play encourage learners as they move from novice to master breeders. Learners can click on the Why button to learn more about genes and dog breeding.

2012-06-26

34

Dog Fights  

ERIC Educational Resources Information Center

Bringing service animals into schools raises serious questions about how to meet one student's special needs while ensuring the educational well-being of all. This article discusses how schools grapple with the practical and legal questions involved in allowing service dogs on campus. The author cites a case in 2009 called "Kalbfleisch v. Columbia…

Taylor, Kelley R.

2010-01-01

35

Ask Dog Lady  

NSDL National Science Digital Library

What to do with a problem dog? What is the best book on dog training? Would Tony Soprano benefit from owning a dog? How can you trust your dog walker with your dog? All these questions are addressed by the Dog Lady, who gives advice, as she says herself, on "dogs, love, and life." Always readable and often funny, the Dog Lady answers emails from viewers with questions about their canine pets. Users can read recent columns or review the "Best in Show" archive, a collection of the Dog Lady's most memorable advice. [CH

36

Gene flow between wolf and shepherd dog populations in Georgia (Caucasus).  

PubMed

We studied the distribution of the mitochondrial DNA haplotypes and microsatellite genotypes at 8 loci in 102 gray wolves, 57 livestock guarding dogs, and 9 mongrel dogs from Georgia (Caucasus). Most of the studied dogs had mitochondrial haplotypes clustered with presumably East Asian dog lineages, and most of the studied wolves had the haplotypes clustered with European wolves, but 20% of wolves and 37% of dogs shared the same mitochondrial haplotypes. Bayesian inference with STRUCTURE software suggested that more than 13% of the studied wolves had detectable dog ancestry and more than 10% of the dogs had detectable wolf ancestry. About 2-3% of the sampled wolves and dogs were identified, with a high probability, as first-generation hybrids. These results were supported by the relatedness analysis, which showed that 10% of wolves and 20% of dogs had closest relatives from an opposite group. The results of the study suggest that wolf-dog hybridization is a common event in the areas where large livestock guarding dogs are held in a traditional way, and that gene flow between dogs and gray wolves was an important force influencing gene pool of dogs for millennia since early domestication events. This process may have been terminated 1) in areas outside the natural range of gray wolves and 2) since very recent time, when humans started to more tightly control contacts of purebred dogs. PMID:24622972

Kopaliani, Natia; Shakarashvili, Maia; Gurielidze, Zurab; Qurkhuli, Tamar; Tarkhnishvili, David

2014-01-01

37

PBS-Nova: Dogs And More Dogs  

NSDL National Science Digital Library

This Nova website, designed to accompany a television Feature Program on the world of Dogs, asks "How and why did man's best friend evolve from wolves, and why are dogs so remarkably diverse today?" The site showcases a slide show on working dogs and an interactive matching game entitled, Dogs Around the World. Also included at this website are a Teacher's Guide, a Links and Books page, and an Inquiry Article about Dog diversity. Additionally, this site links to the TV program transcript and to a recent "washingtonpost.com discussion with biologist and dog expert Ray Coppinger."

38

Cecal perforation and adrenocortical adenoma in a dog.  

PubMed

Cecal perforation was diagnosed in a dog with a history of acute vomiting. The dog also had an adrenocortical adenoma. Intestinal perforation can be a serious complication of cortico-steroid treatment in the dog, but has not been attributable to hyperadrenocorticism. Fever and an inflammatory CBC were not observed, which could have been secondary to adrenal-dependent hyperadrenocorticism. The acute abdominal crisis associated with peritonitis required quick resolution in an attempt to save the dog, but also precluded any further diagnostic procedures for possible hyperadrenocorticism. The signs that suggested hyper-adrenocorticism in this dog included alopecia, lymphopenia, eosinopenia, high liver enzyme activities, hypercholesterolemia, and one large and one small adrenal gland. This latter finding presumably indicated negative feedback suppression and atrophy attributable to a functional adrenocortical adenoma. PMID:3610787

Moore, M P; Robinette, J D

1987-07-01

39

KEEPING OURSELVES SAFE NEAR DOGS  

E-print Network

KEEPING OURSELVES SAFE NEAR DOGS Kendal Shepherd (BVSc, CCAB, MRCVS) Adapted for classroom use;2 Keeping ourselves safe near dogs 1 Do you have a pet dog? 2 Do you like dogs? 3 Does a relative of yours have a pet dog? 4 What makes dogs likely to bite? 5 How can we prevent a dog biting us? 6 Is a small

Little, Tony

40

Cat and Dog Bites  

MedlinePLUS

MENU Return to Web version Cat and Dog Bites Cat and Dog Bites How should I take care of a bite from a cat or a dog? Whether from a family pet or a neighborhood stray, cat and dog bites are common. Here are some ...

41

Reversible intermittent rhythmic myoclonus with fluoxetine in presumed Pick's disease.  

PubMed

A 61-year-old man with presumed Pick's disease was successfully treated with fluoxetine for pathological affect. Severe intermittent, rhythmically repetitive trains of myoclonus developed suddenly the following year. A dystonic-like component involving the shoulder region and a decrescendo frequency pattern were observed. Myoclonus involved the face, palate, shoulder, neck, upper chest and back, diaphragm, hips, and upper extremities, especially on the right side. Movements were not influenced by postural adjustments, startle, or other stimuli. Movements proved insensitive to benztropine but abated with discontinuation of fluoxetine. Rechallenge with fluoxetine or trazodone evoked the movements, whereas clonazepam and chloral hydrate abolished the movements. The pattern of myoclonus is unlike previous reported cases and may relate to activation of serotonin 5HT1A receptors (possibly supersensitive in Pick's disease) or to hypodopaminergia. Although fluoxetine may be useful as adjunct therapy in dementing disorders, caution may be warranted in its use in Pick's disease. PMID:8041377

Lauterbach, E C

1994-05-01

42

Presumed Symbolic Use of Diurnal Raptors by Neanderthals  

PubMed Central

In Africa and western Eurasia, occurrences of burials and utilized ocher fragments during the late Middle and early Late Pleistocene are often considered evidence for the emergence of symbolically-mediated behavior. Perhaps less controversial for the study of human cognitive evolution are finds of marine shell beads and complex designs on organic and mineral artifacts in early modern human (EMH) assemblages conservatively dated to ?100–60 kilo-years (ka) ago. Here we show that, in France, Neanderthals used skeletal parts of large diurnal raptors presumably for symbolic purposes at Combe-Grenal in a layer dated to marine isotope stage (MIS) 5b (?90 ka) and at Les Fieux in stratigraphic units dated to the early/middle phase of MIS 3 (60–40 ka). The presence of similar objects in other Middle Paleolithic contexts in France and Italy suggest that raptors were used as means of symbolic expression by Neanderthals in these regions. PMID:22403717

Morin, Eugčne; Laroulandie, Véronique

2012-01-01

43

Infectious endotheliitis: a rare case of presumed mycotic origin  

PubMed Central

Purpose To report an interesting case of infectious endotheliitis of presumed mycotic origin. Methods A case report of a 56-year-old male farmer who sought medical attention after a month-long evolution of irritative symptoms in his right eye, accompanied by visual acuity (VA) impairment. The patient received topical and oral broad-spectrum antibiotic treatment with no improvement before being referred to a cornea specialist, where he was found to have VA of 20/150 and was noted on biomicroscopy to have endothelial feathery coalescent lesions. The patient was admitted to the hospital for an aqueous humor sample and intravenous voriconazole. Results The microbiological studies did not isolate any micro-organisms. However, clinical evidence of improvement was confirmed after 5 days of antimycotic intravenous therapy. Complete clinical resolution was achieved at 1 month after treatment completion with oral voriconazole, as evidenced by VA of 20/20 and disappearance of endothelial lesions. Conclusion Endothelial involvement by fungi is a rare condition. In this case, no microbes were isolated, but the characteristic morphology of the lesions, the history of onychomycosis, and the spectacular response to voriconazole turn this case into a valid presumptive diagnosis. PMID:23901253

Zapata, Luis Fernando; Paulo, José David; Restrepo, Carlos A; Velásquez, Luis Fernando; Montoya, Andrés E Toro; Zapata, Melissa A

2013-01-01

44

Two successive necrotic lesions secondary to presumed loxosceles envenomation.  

PubMed

Brown recluse spider (Loxosceles reclusa) envenomations with subsequent necrotic skin lesions occur infrequently, and systemic loxoscelism is rarer still. We report a case of 2 successive developing necrotic lesions, each on adjacent medial aspects of the legs, secondary to presumed Loxosceles envenomation. A 31-year-old man with no significant past medical history presented to the emergency department with 2, large, necrotic lesions, 1 on each medial thigh. They had progressed over the course of 1 month from small blisters to large necrotic lesions with eschar. He underwent surgical debridement without skin grafting with no further complications. Bites from recluse spiders that progress to necrosis usually present as single lesions. The differential diagnoses for a necrotic skin lesion is large. The presence of more than 1 lesion argues against Loxosceles envenomation; however, in the absence of underlying infection, systemic diseases, immunodeficiency, or malignancy, the diagnosis must be considered if the case presents in an endemic area. Brown recluse spiders rarely bite multiple times, thus confounding the diagnosis of an already nonspecific clinical finding. PMID:23352313

Tarullo, David B; Jacobsen, Ryan C; Algren, D Adam

2013-06-01

45

Management of presumed benign ovarian tumors: updated French guidelines.  

PubMed

Transvaginal pelvic ultrasound is the first-line imaging examination for presumed benign ovarian tumors (PBOT) in adult women (Grade A). Ultrasound is sufficient for characterizing a unilocular anechoic cyst smaller than 7cm (Grade A). Magnetic resonance imaging is the recommended second-line investigation for indeterminate masses or masses larger than 7cm (Grade B). Serum CA-125 assay is not recommended for first-line diagnosis in adult women (Grade C). In women with a unilocular anechoic cyst, hormone therapy is ineffective and not recommended (Grade A). Ultrasound-guided aspiration is not recommended (Grade B). Abstention is an option in adult women with a unilocular asymptomatic anechoic cyst smaller than 10cm and no history of cancer (Grade B). If symptoms develop, laparoscopy is the gold standard for surgical treatment of PBOT (Grade A). Conservative surgical treatment (cystectomy) should be preferred to oophorectomy in pre-menopausal women without a previous history of cancer (Grade C). In cases of suspected adnexal torsion, laparoscopic surgical exploration is recommended (Grade B). Conservative treatment or detorsion without oophorectomy is recommended for pre-menopausal women regardless of the estimated torsion duration and macroscopic appearance of the ovary (Grade B). During pregnancy, expectant management is recommended for unilocular asymptomatic anechoic cysts smaller than 6cm (Grade C). PMID:25461353

Brun, J-L; Fritel, X; Aubard, Y; Borghese, B; Bourdel, N; Chabbert-Buffet, N; Collinet, P; Deffieux, X; Dubernard, G; Huchon, C; Kalfa, N; Lahlou, N; Marret, H; Pienkowski, C; Sevestre, H; Thomassin-Naggara, I; Levęque, J

2014-12-01

46

From Wolf to Dog  

NSDL National Science Digital Library

During this video-enhanced lesson, students will learn that all dogs came from one ancestor- the wolf. Students will watch and discuss video segments from the NATURE film “Dogs that Changed the World,” and explore different theories about how this transformation happened. Students will learn about different breeds of dogs and create a book with pictures and information about a variety of dog breeds. In the culminating activity, students will interview a dog owner and create a poster and/or a presentation about his/her dog.

2010-01-01

47

Presumably bacterial remains in banded iron formations: beginning of investigations  

NASA Astrophysics Data System (ADS)

Ancient Archaean and Protherozoic rocks are the model objects for investigation of rocks comprising astromaterials. Judging by their age these terrestrial rocks are the nearest to the rocks of meteorites. They are represented as a rule by deeply metamorphized layers of volcanogenic and volcanogenic-sedimentary rocks and bacterial-paleontological investigations of these rocks usually meet some difficulties. But paleontological studies of these rocks usually meet some difficulties. One of these difficulties is usual high metamorphization of rocks. That is why investigation of Archaean banded iron formations is of great importance. Banded iron formations are known everywhere. The oldest banded iron formations are met in Archaean. Their widest distribution was in Proterozoic. They are constituent part of metamorphic complexes of all ancient shields. Formation of these units ended in Phanerozoic. Peculiarity of their development in time, thin layering, rhythmyc repetitiveness are reasons of great interest to these formations. Banded iron formations are sedimentary rocks. Interbedding of ferrigenous (magnetite, hematite, siderite etc.) interlayers and siliceous layers are typical to these formations. Stratificatification is thin, thickness of interlayers is less than 1-2 mm. Iron content exceeds 15%. Potentially all minerals of ferrigenous interlayers could be of biogenic nature because both for oxygenized (hematite) and reduced (magnetite and siderite) minerals direct mechanism of bacterial production is established by microbiologists. Basic ore mineral of banded iron formations is magnetite. But magnetite origin is not clear till nowadays and this problem is very actual [2]. Nevertheless bacterial remains by themselves have not been found and it is not surprising. It is proved that finely dispersed non-completely formed magnetite compose basic mass of magnetite formed for example by thermophylic iron-reducing bacteria. Processes of structure arrangement and crystal enlargement are occurred under sediment ageing and abiogenic magnetite recrystallization [1]. That is why in nature in case of ancient sediments and metamorphic rocks it is almost impossible to reveal biogenic origin of magnetite [3]. We decided to begin studying problem of banded iron formations origin because of its great interest. Archaean (2.75 GA) banded iron formations of Olenegorsk deposit (Kola Peninsula) were chosen as a model object. Material was kindly lent us by our colleagues from Institute of Precambrian Geology and Geochronology - S. Felitsyn and N. Alfimova. Interesting results were received while bacterial-paleontological studying. Threadlike, coccoidal, dumbbell-like etc. forms presumably of bacterial nature were discovered. The most abundant and diverse forms are those close to coccoidal - the very cocci, oval, dumbbell-like etc. forms. Sizes of the most part of discovered objects about 1 ?m. Thread-like forms are met less often and mainly are represented by long thin single threads. The most part of biogenic structures was found in ferruginous interlayers. The whole rock fragments often consist almost completely from such structures, biogenic forms sink into rock matrix, some images show their location inside rock sample. There are no reasons to doubt that these biogenic forms were found in situ. In siliceous interlayers presumably biogenic forms are very rare. There are mainly long thin thread-like forms merged with the rock. As can be seen from the above it is possible to make preliminary conclusion about Archaean of banded iron formations biogenic origin and about microorganism participation in the process of banded iron formations formation. Investigations are continuing.

Astafieva, M.

2014-04-01

48

[Ovarian tumor markers of presumed benign ovarian tumors].  

PubMed

Cancer Antigen 125 (CA125) and Human Epididymis Protein 4 (HE4) are the most studied ovarian tumor markers. Their diagnostic performance for identification of ovarian cancer are superior to CA19-9, CA72-4, and carcinoembryonic antigen, which are no more recommended for the diagnosis of presumed benign ovarian tumor. HE4 (>140 pmol/L) is superior to CA125 (>30 U/mL) in terms of specificity and positive likelihood ratio. CA125 and HE4 can be combined into an algorithm ROMA, or associated to clinical information (composite index), biological data (OVA1) or imaging (Risk for Malignancy Index (RMI), LR2). ROMA algorithm is an exponential equation combining plasmatic concentrations of HE4 and CA125. ROMA is more sensitive and less specific than HE4 in predicting epithelial ovarian cancer. ROMA is more accurate in post-menopausal women. The performance of ROMA is lower than the ultrasound model LR2 in differentiating malignant from benign ovarian tumors, whatever the hormonal status. The composite index combining CA125 with a symptoms index (pain, abdominal distension, bloating, difficulty eating) has a good sensitivity in a screening program, but because of a 12% false positive rate, ultrasound is required before management. The RMI algorithm is based on serum CA125, ultrasound findings (septation, solid zones, metastases, ascite, bilaterality) and menopausal status. RMI is less sensitive, but more specific than ROMA or OVA1 for the classification of ovarian masses. The addition of HE4 to RMI seems to be the most accurate. The subjective evaluation of ovarian cysts by sonography and color Doppler is better than ROMA and RMI algorithms, and not affected by the hormonal status. PMID:24210243

Lahlou, N; Brun, J-L

2013-12-01

49

Dog epilepsy gene  

NSDL National Science Digital Library

Scientists have now identified a genetic mutation responsible for epilepsy in dogs. Further research on dogs with this mutation might help researchers better understand how to treat or prevent seizures in humans with Lafora disease, according to the authors.

American Association for the Advancement of Science (AAAS; )

2005-01-07

50

Pre-Columbian origins of Native American dog breeds, with only limited replacement by European dogs, confirmed by mtDNA analysis  

PubMed Central

Dogs were present in pre-Columbian America, presumably brought by early human migrants from Asia. Studies of free-ranging village/street dogs have indicated almost total replacement of these original dogs by European dogs, but the extent to which Arctic, North and South American breeds are descendants of the original population remains to be assessed. Using a comprehensive phylogeographic analysis, we traced the origin of the mitochondrial DNA lineages for Inuit, Eskimo and Greenland dogs, Alaskan Malamute, Chihuahua, xoloitzcuintli and perro sín pelo del Peru, by comparing to extensive samples of East Asian (n = 984) and European dogs (n = 639), and previously published pre-Columbian sequences. Evidence for a pre-Columbian origin was found for all these breeds, except Alaskan Malamute for which results were ambigous. No European influence was indicated for the Arctic breeds Inuit, Eskimo and Greenland dog, and North/South American breeds had at most 30% European female lineages, suggesting marginal replacement by European dogs. Genetic continuity through time was shown by the sharing of a unique haplotype between the Mexican breed Chihuahua and ancient Mexican samples. We also analysed free-ranging dogs, confirming limited pre-Columbian ancestry overall, but also identifying pockets of remaining populations with high proportion of indigenous ancestry, and we provide the first DNA-based evidence that the Carolina dog, a free-ranging population in the USA, may have an ancient Asian origin. PMID:23843389

van Asch, Barbara; Zhang, Ai-bing; Oskarsson, Mattias C. R.; Klütsch, Cornelya F. C.; Amorim, António; Savolainen, Peter

2013-01-01

51

Lentiviral vector-mediated doxycycline-inducible USP39 shRNA or cDNA expression in triple-negative breast cancer cells.  

PubMed

Triple-negative breast cancer (TNBC), characterized by distinct biological and clinicopathological features, has a poor prognosis due to lack of effective therapeutic targets. Our previous data revealed that high levels of USP39 were selectively present in TNBC samples compared with their normal breast tissue samples and USP39 was also expressed at different levels in cultured TNBC cells and normal breast cells. Yet, the underlying cellular and molecular mechanisms of USP39 remain unclear. In the present study, we describe a doxycycline (DOX)-regulated lentiviral vector system expressing shRNA or cDNA of the USP39 gene in the TNBC cell line MDA-MB-231. USP39 expression was knocked down by the miR-30-based inducible lentiviral short hairpin RNA (shRNA) delivery system or overexpressed by the inducible cDNA system. The inducible shRNA-mediated downregulation of USP39 expression markedly reduced the proliferation and colony-forming ability of MDA-MB-231 cells, while overexpression of USP39 by the inducible system did not promote cancer cell proliferation. The lentiviral vector-mediated Tet-on system demonstrated efficient and inducible knockdown of USP39 or overexpression of USP39 in TNBC cells, facilitating a wide variety of applications for gene knockdown and overexpression experiments in gene functional studies in vitro and in vivo. PMID:25812575

Liu, Shihai; Liu, Xiangping; Wang, Haibo; Zhou, Quan; Liang, Ye; Sui, Aihua; Yao, Ruyong; Zhao, Bin; Sun, Ming

2015-05-01

52

Tick-borne pathogens and disease in dogs on St. Kitts, West Indies.  

PubMed

Between 2009 and 2011, we conducted a case-control study of ticks and tick-associated pathogens affecting dogs on the island of St. Kitts, eastern Caribbean, including 55 cases of clinically suspected tick-borne disease (TBD) and 110 presumably healthy animals presented for elective surgeries. Rhipicephalus sanguineus caused year-round infestations of dogs, and 36% of the dogs in the study were infested at the time of examination. Overall, 62% of suspected TBD cases and 24% of presumably healthy dogs tested positive by PCR for infections with: Anaplasma platys (0% and 4%), Babesia canis vogeli (20% and 6%), Babesia gibsoni (18% and 5%), Ehrlichia canis (35% and 7%), and Hepatozoon canis (5% and 2%). Co-infections were documented in 15% of these PCR-positive dogs. Antibodies against A. platys or E. canis were noted in 36% of the dogs. Thrombocytopenia was the most common sign of infection, followed by anemia. This is the first detection of A. platys, B. canis vogeli, or H. canis on St. Kitts and the first detection of B. gibsoni in the Caribbean. We conclude that tick-borne pathogens of dogs are highly prevalent in this region and may present in dogs that appear healthy, in spite of hematologic abnormalities that may increase surgical risk. PMID:23481028

Loftis, Amanda D; Kelly, Patrick J; Freeman, Mark D; Fitzharris, Susan; Beeler-Marfisi, Janet; Wang, Chengming

2013-09-01

53

Optimization of adenoviral vector–mediated transgene expression in the canine brain in vivo, and in canine glioma cells in vitro  

PubMed Central

Expression of the immune-stimulatory molecule Fms-like tyrosine kinase 3 ligand (Flt3L) and the conditional cytotoxic enzyme herpes simplex virus type 1 thymidine kinase (HSV1-TK) provides long-term immune-mediated survival of large glioblastoma multiforme (GBM) models in rodents. A limitation for predictive testing of novel antiglioma therapies has been the lack of a glioma model in a large animal. Dogs bearing spontaneous GBM may constitute an attractive large-animal model for GBM, which so far has remained underappreciated. In preparation for a clinical trial in dogs bearing spontaneous GBMs, we tested and optimized adenovirus-mediated transgene expression with negligible toxicity in the dog brain in vivo and in canine J3T glioma cells. Expression of the marker gene ?-galactosidase (?-Gal) was higher when driven by the murine (m) than the human (h) cytomegalovirus (CMV) promoter in the dog brain in vivo, without enhanced inflammation. In the canine brain, ?-Gal was expressed mostly in astrocytes. ?-Gal activity in J3T cells was also higher with the mCMV than the hCMV promoter driving tetracycline-dependent (TetON) trans-gene expression within high-capacity adenovirus vectors (HC-Ads). Dog glioma cells were efficiently transduced by HC-Ads expressing mCMV-driven HSV1-TK, which induced 90% reduction in cell viability in the presence of ganciclovir. J3T cells were also effectively transduced with HC-Ads expressing Flt3L under the control of the regulatable TetON promoter system, and as predicted, Flt3L release was stringently inducer dependent. HC-Ads encoding therapeutic transgenes under the control of regulatory sequences driven by the mCMV promoter are excellent vectors for the treatment of spontaneous GBM in dogs, which constitute an ideal preclinical animal model. PMID:17522335

Candolfi, Marianela; Pluhar, G. Elizabeth; Kroeger, Kurt; Puntel, Mariana; Curtin, James; Barcia, Carlos; Muhammad, A.K.M. Ghulam; Xiong, Weidong; Liu, Chunyan; Mondkar, Sonali; Kuoy, William; Kang, Terry; McNeil, Elizabeth A.; Freese, Andrew B.; Ohlfest, John R.; Moore, Peter; Palmer, Donna; Ng, Phillip; Young, John D.; Lowenstein, Pedro R.; Castro, Maria G.

2007-01-01

54

Longitudinal follow-up study of adenoviral vector-mediated gene transfer of dopamine d 2 receptors in the striatum in young, middle-aged, and aged rats: a positron emission tomography study  

Microsoft Academic Search

Overexpression of dopamine D2 receptors by adenoviral vector-mediated gene transfer in the rat striatum was evaluated by positron emission tomography in vivo and by ex vivo autoradiography in 5-, 13-, and 24-month-old Fischer 344 rats. Each rat had hemilateral gene transfer of D2 receptors mediated by adenoviral vectors (AdCMV.DopD2R) in the striatum with contralateral striatal injection of control vectors (AdCMV.LacZ).

H Umegaki; K Ishiwata; O Ogawa; D. K Ingram; G. S Roth; K Oda; S Kurotani; K Kawamura; W. F Wang; H Ikari; M Senda; A Iguchi

2003-01-01

55

Is That Dog a Pit Bull? A Cross-Country Comparison of Perceptions of Shelter Workers Regarding Breed Identification  

PubMed Central

Bull breeds are commonly kept as companion animals, but the pit bull terrier is restricted by breed-specific legislation (BSL) in parts of the United States and throughout the United Kingdom. Shelter workers must decide which breed(s) a dog is. This decision may influence the dog's fate, particularly in places with BSL. In this study, shelter workers in the United States and United Kingdom were shown pictures of 20 dogs and were asked what breed each dog was, how they determined each dog's breed, whether each dog was a pit bull, and what they expected the fate of each dog to be. There was much variation in responses both between and within the United States and United Kingdom. UK participants frequently labeled dogs commonly considered by U.S. participants to be pit bulls as Staffordshire bull terriers. UK participants were more likely to say their shelters would euthanize dogs deemed to be pit bulls. Most participants noted using dogs' physical features to determine breed, and 41% affected by BSL indicated they would knowingly mislabel a dog of a restricted breed, presumably to increase the dog's adoption chances. PMID:24673506

Hoffman, Christy L.; Harrison, Natalie; Wolff, London; Westgarth, Carri

2014-01-01

56

Genetic modification of mouse bone marrow by lentiviral vector-mediated delivery of HPRT shRNA confers chemoprotection against 6-thioguanine cytotoxicity  

PubMed Central

We have recently developed a novel and highly efficient strategy that exclusively employs the purine analog 6-thioguanine (6TG) for both pre-transplant conditioning and post-transplant chemoselection of hypoxanthine-guanine phosphoribosyltransferase (HPRT)-deficient bone marrow (BM). In a mouse BM transplant model, combined 6TG preconditioning and in vivo chemoselection consistently achieved >95% engraftment of HPRT-deficient donor BM and long-term reconstitution of histologically and immunophenotypically normal hematopoiesis in both primary and secondary recipients, without significant toxicity and in the absence of any other cytotoxic conditioning regimen. In order to translate this strategy for combined 6TG conditioning and chemoselection into a clinically feasible approach, it is necessary to develop methods for genetic modification of normal HSC to render them HPRT-deficient and thus 6TG-resistant. Here we investigated a strategy to reduce HPRT expression and thereby confer protection against 6TG myelotoxicity to primary murine bone marrow cells by RNA interference (RNAi). Accordingly, we constructed and validated a lentiviral gene transfer vector expressing short-hairpin RNA (shRNA) that targets the murine HPRT gene. Our results showed that lentiviral vector-mediated delivery of HPRT-targeted shRNA could achieve effective and long-term reduction of HPRT expression. Furthermore, in both an established murine cell line as well as in primary murine bone marrow cells, lentiviral transduction with HPRT-targeted shRNA was associated with enhanced resistance to 6TG cytotoxicity in vitro. Hence this represents a translationally feasible method to genetically engineer HSC for implementation of 6TG-mediated preconditioning and in vivo chemoselection. PMID:23769104

Hacke, Katrin; Treger, Janet A.; Bogan, Brooke T.; Schiestl, Robert H.; Kasahara, Noriyuki

2014-01-01

57

The impact of presumed consent legislation on cadaveric organ donation: A cross-country study  

Microsoft Academic Search

In the U.S., Great Britain and in many other countries, the gap between the demand and the supply of human organs for transplantation is on the rise, despite the efforts of governments and health agencies to promote donor registration. In some countries of continental Europe, however, cadaveric organ procurement is based on the principle of presumed consent. Under presumed consent

Alberto Abadie; Sebastien Gay

2006-01-01

58

The Impact of Presumed Consent Legislation on Cadaveric Organ Donation: A Cross Country Study  

Microsoft Academic Search

In the U.S., Great Britain, and in many other countries, the gap between the demand and the supply of human organs for transplantation is on the rise, despite the efforts of governments and health agencies to promote donor registration. In some countries of continental Europe, however, cadaveric organ procurement is based on the principle of presumed consent. Under presumed consent

Alberto Abadie; Sebastien Gay

2004-01-01

59

Carolyn with Prairie Dog  

USGS Multimedia Gallery

The USGS National Wildlife Health Center works to identify, track, and prevent wildlife disease. A USGS technician works with a prairie dog as part of the center's efforts to protect prairie dogs, and in turn the endangered black-footed ferret, from plague....

60

Marked Prairie Dog  

USGS Multimedia Gallery

The chin of an anaesthetized prairie dog in Wind Cave National Park is marked before the animal is released back into the wild. Over 30 organizations and agencies are testing a USGS-developed oral vaccine to prevent the spread of plague in prairie dogs. If successful, the sylvat...

61

Drawing Prairie Dog Blood  

USGS Multimedia Gallery

Blood is taken from an anaesthetized prairie dog in Wind Cave National Park.  Over 30 organizations and agencies are testing a USGS-developed oral vaccine to prevent the spread of plague in prairie dogs. If successful, the sylvatic plague vaccine could help protect endanger...

62

Prairie Dog in Trap  

USGS Multimedia Gallery

A prairie dog trapped outside its burrow in Wind Cave National Park waits for a crew of scientists to arrive. The animal is part of a field test to determine the effectiveness of a USGS-developed oral sylvatic plague vaccine (SPV). This prairie dog will either be brought to a research van for blood ...

63

Prairie Dog Tagging  

USGS Multimedia Gallery

An anaesthetized prairie dog is tagged in Wind Cave National Park.  Over 30 organizations and agencies are testing a USGS-developed oral vaccine to prevent the spread of plague in prairie dogs. If successful, the sylvatic plague vaccine could help protect endangered black-f...

64

Trapped Prairie Dog  

USGS Multimedia Gallery

A prairie dog trapped outside its burrow in Wind Cave National Park waits for a crew of scientists to arrive. The animal is part of a field test to determine the effectiveness of a USGS-developed oral sylvatic plague vaccine (SPV). This prairie dog will either be brought to a research van for blood ...

65

Anesthetizing a Prairie Dog  

USGS Multimedia Gallery

National Park Service veterinarian Kevin Castle places a prairie dog under anesthesia in Wind Cave National Park. He will tag this trapped prairie dog and take hair, whisker, and blood samples before scientists release the animal back into the wild. Over 30 organizations and agencies are&...

66

Sampling Prairie Dog Fur  

USGS Multimedia Gallery

Fur samples are taken from an anaesthetized prairie dog in Wind Cave National Park.  Over 30 organizations and agencies are testing a USGS-developed oral vaccine to prevent the spread of plague in prairie dogs. If successful, the sylvatic plague vaccine could help protect e...

67

Prairie Dog Under Anesthesia  

USGS Multimedia Gallery

Over 30 organizations and agencies are testing a USGS-developed oral vaccine to prevent the spread of plague in prairie dogs. If successful, the sylvatic plague vaccine could help protect endangered black-footed ferrets in the western U.S. because the ferrets rely on prairie dogs for ...

68

One Dog Policy  

E-print Network

Broadcast Transcript: First the one child policy and now the one dog policy. First in Beijing and now in Guangzhou, the government is limiting the number of dogs in any household to one. And the regulation wasn't grandfathered in, meaning if you had...

Hacker, Randi

2009-08-19

69

Dogs Over Babies  

E-print Network

wee babe you find a wee dog. In a frilly t-shirt. Meet Japan's newest demographic: Career-oriented women who choose dogs instead of babies, careers instead of motherhood. These women spend big bucks on doggie accessories, doggie parties and doggie spas...

Hacker, Randi; Tsutsui, William

2007-08-19

70

Do Dogs Know Bifurcations?  

ERIC Educational Resources Information Center

When a dog (in this case, Tim Pennings' dog Elvis) is in the water and a ball is thrown downshore, it must choose to swim directly to the ball or first swim to shore. The mathematical analysis of this problem leads to the computation of bifurcation points at which the optimal strategy changes.

Minton, Roland; Pennings, Timothy J.

2007-01-01

71

Dog Ownership, Dog Walking, and Children's and Parents' Physical Activity  

ERIC Educational Resources Information Center

This study aimed to determine cross-sectional associations of dog ownership, dog walking, and physical activity (PA) among children and their parents. Objective measures of PA were obtained for children ages 5-6 and 10-12 years from 19 primary schools across Melbourne, Australia. Parents self-reported their PA, dog ownership, and frequency of dog

Salmon, Jo; Timperio, Anna; Chu, Binh; Veitch, Jenny

2010-01-01

72

Dogs Are Not for Dinner  

E-print Network

Broadcast Transcript: Dogs. They're not just for dinner anymore. Over the years, many a Chinese diner has cooked and served dog and there's a story about an emperor from ancient times whose favorite meat was dog meat. And while dog is still...

Hacker, Randi

2011-02-23

73

Animal Planet: Dog Breed Directory  

NSDL National Science Digital Library

Are you considering bringing a canine into the family, and wondering which type of dog would be the best fit? This website from Animal Planet provides potential dog owners with information about a variety of breeds. The site directory lists dogs under such categories as Hound, Sporting, Terrier, Working, Herding, and more. Site visitors can view profiles for many different types of dogs including the Bernese Mountain Dog, Irish Setter, Old English Sheepdog, and Tibetan Spaniel. Dog profiles contain a photograph, Rating of Characteristics; and concise sections addressing History, Temperament, Form and Function, Upkeep, and Health. Profiles also include a hyperlinked list of related dogs.

74

Impact of presumed consent for organ donation on donation rates: a systematic review  

PubMed Central

Objectives To examine the impact of a system of presumed consent for organ donation on donation rates and to review data on attitudes towards presumed consent. Design Systematic review. Data sources Studies retrieved by online searches to January 2008 of Medline, Medline In-Process, Embase, CINAHL, PsycINFO, HMIC, PAIS International, and OpenSIGLE. Studies reviewed Five studies comparing donation rates before and after the introduction of legislation for presumed consent (before and after studies); eight studies comparing donation rates in countries with and without presumed consent systems (between country comparisons); 13 surveys of public and professional attitudes to presumed consent. Results The five before and after studies represented three countries: all reported an increase in donation rates after the introduction of presumed consent, but there was little investigation of any other changes taking place concurrently with the change in legislation. In the four best quality between country comparisons, presumed consent law or practice was associated with increased organ donation—increases of 25-30%, 21-26%, 2.7 more donors per million population, and 6.14 more donors per million population in the four studies. Other factors found to be important in at least one study were mortality from road traffic accidents and cerebrovascular causes, transplant capacity, gross domestic product per capita, health expenditure per capita, religion (Catholicism), education, public access to information, and a common law legal system. Eight surveys of attitudes to presumed consent were of the UK public. These surveys varied in the level of support for presumed consent, with surveys conducted before 2000 reporting the lowest levels of support (28-57%). The most recent survey, in 2007, reported that 64% of respondents supported a change to presumed consent. Conclusion Presumed consent alone is unlikely to explain the variation in organ donation rates between countries. Legislation, availability of donors, organisation and infrastructure of the transplantation service, wealth and investment in health care, and public attitudes to and awareness of organ donation may all play a part, but their relative importance is unclear. Recent UK surveys show support for presumed consent, though with variation in results that may reflect differences in survey methods. PMID:19147479

2009-01-01

75

BigDog  

NASA Astrophysics Data System (ADS)

BigDog's goal is to be the world's most advanced quadruped robot for outdoor applications. BigDog is aimed at the mission of a mechanical mule - a category with few competitors to date: power autonomous quadrupeds capable of carrying significant payloads, operating outdoors, with static and dynamic mobility, and fully integrated sensing. BigDog is about 1 m tall, 1 m long and 0.3 m wide, and weighs about 90 kg. BigDog has demonstrated walking and trotting gaits, as well as standing up and sitting down. Since its creation in the fall of 2004, BigDog has logged tens of hours of walking, climbing and running time. It has walked up and down 25 & 35 degree inclines and trotted at speeds up to 1.8 m/s. BigDog has walked at 0.7 m/s over loose rock beds and carried over 50 kg of payload. We are currently working to expand BigDog's rough terrain mobility through the creation of robust locomotion strategies and terrain sensing capabilities.

Playter, R.; Buehler, M.; Raibert, M.

2006-05-01

76

Dogs Discriminate Identical Twins  

PubMed Central

Earlier studies have shown variation among experimental attempts to establish whether human monozygotic twins that are genetically identical also have identical individual scents. In none of the cases were the dogs able to distinguish all the individual scents of monozygotic twins living in the same environment if the scents were presented to them separately. Ten specially trained police German Shepherd dogs of three Czech Republic Police Regional Headquarters were used for scent identification in our study. The dogs were supposed to match scents of two monozygotic pairs (5 and 7 years old) and two dizygotic twin pairs (8 and 13 years old). Scents were collected on cotton squares stored in glass jars. Dog handlers were blind to the experiment details. In each trial (line-up), one scent was used as a starting scent and the dog was then sent to determine if any of the 7 presented glass jars contained a matching scent. Scents of children of similar ages were used as distractors. In the matching procedure, the dogs matched correctly the scent of one twin with the other, as well as two scents collected from every single identical and non-identical twin to prove their efficacy and likewise, the presence of the matching twin scent in any given glass jar. All dogs in all trials distinguished correctly the scents of identical as well as non-identical twins. All dogs similarly matched positively two scents collected from the same individuals. Our findings indicated that specially trained German Shepherd dogs are able to distinguish individual scents of identical twins despite the fact that they live in the same environment, eat the same food and even if the scents are not presented to them simultaneously. PMID:21698282

Pinc, Ludvík; Bartoš, Lud?k; Reslová, Alice; Kotrba, Radim

2011-01-01

77

20 CFR 404.721 - Evidence to presume a person is dead.  

Code of Federal Regulations, 2010 CFR

...SOCIAL SECURITY ADMINISTRATION FEDERAL OLD-AGE, SURVIVORS AND DISABILITY INSURANCE (1950- ) Evidence Evidence of Age, Marriage, and Death § 404.721 Evidence to presume a person is dead. If you cannot prove the person is dead but...

2010-04-01

78

Jealousy in Dogs  

PubMed Central

It is commonly assumed that jealousy is unique to humans, partially because of the complex cognitions often involved in this emotion. However, from a functional perspective, one might expect that an emotion that evolved to protect social bonds from interlopers might exist in other social species, particularly one as cognitively sophisticated as the dog. The current experiment adapted a paradigm from human infant studies to examine jealousy in domestic dogs. We found that dogs exhibited significantly more jealous behaviors (e.g., snapping, getting between the owner and object, pushing/touching the object/owner) when their owners displayed affectionate behaviors towards what appeared to be another dog as compared to nonsocial objects. These results lend support to the hypothesis that jealousy has some “primordial” form that exists in human infants and in at least one other social species besides humans. PMID:25054800

Harris, Christine R.; Prouvost, Caroline

2014-01-01

79

Let the Dogs Out!  

NSDL National Science Digital Library

Even the simplest of toys can be great tools for promoting interest in physical science principles. The author developed a strategy based on the 5E learning cycle (Engage, Explore, Explanation, Elaboration, and Evaluation) that uses bobble head dogs to explore the principles of force and motion, systems, and simple machines. The activity is designed to have students make predictions and ask questions about the internal mechanism that allows the dog's head to bobble, and then construct their own model using simple materials.

Andrea S. Foster

2003-04-01

80

Cryptosporidium spp. in Domestic Dogs: the “Dog” Genotype  

PubMed Central

Genetic and phylogenetic characterization of Cryptosporidium isolates at two loci (18S rRNA gene and heat shock gene) from both Australian and United States dogs demonstrated that dog-derived Cryptosporidium isolates had a distinct genotype which is conserved across geographic areas. Phylogenetic analysis provided support for the idea that the “dog” genotype is, in fact, a valid species. PMID:10788404

Morgan, Una M.; Xiao, Lihua; Monis, Paul; Fall, Abbie; Irwin, Peter J.; Fayer, Ronald; Denholm, Karen M.; Limor, Josef; Lal, Altaf; Thompson, R. C. Andrew

2000-01-01

81

Disease Precautions for Dog Walkers  

MedlinePLUS

... have their pet evaluated by a veterinarian. Severe weather A dog’s tolerance to heat and cold varies ... seem to have a tougher time in hot weather and may require more frequent rests, shorter walks, ...

82

[Dental anatomy of dogs].  

PubMed

The aim of the research was to investigate dog teeth anatomy as animal model for study of etiopathogenesis of caries disease and physiological tooth wear in human. After examining the dog's dental system, following conclusions were drawn: the dog has 42 permanent teeth, which are distributed over the dental arches not equally, and so the upper dentition consists of 20, and the lower of 22 teeth. The largest are considered upper fourth premolar and lower first molars, which are called discordant teeth. Between discordant teeth and fangs a dog has an open bite, which is limited to the top and bottom conical crown premolar teeth. Thus, in the closed position of the jaws, behind this occlusion is limited by discordant teeth, just in contact are smaller in size two molars. Only large dog's molars in a valid comparison can be likened to human molars, which allows us to use them in an analog comparison between them with further study of the morphological features ensure durability short-crown teeth and their predisposition to caries. PMID:25617107

2014-12-01

83

Effects of doxycycline on heartworm embryogenesis, transmission, circulating microfilaria, and adult worms in microfilaremic dogs.  

PubMed

Tetracycline treatment of animals or humans infected with filariae that harbor Wolbachia endosymbionts blocks further embryogenesis, and existing microfilariae gradually die. This treatment also kills developing larvae and has a slow-kill effect on adult filariae, all presumably due to elimination of the Wolbachia. Also, Dirofilaria immitis microfilariae in blood collected from dogs up to 25 days after the last dose of doxycycline developed to infective L3 that were normal in appearance and motility in mosquitoes but did not continue to develop or migrate normally after subcutaneous (SC) injection into dogs. The present study was designed to determine whether heartworm microfilariae collected at later times after treatment would regain the ability to continue normal development in a dog. The study also was expected to yield valuable data on the effects of treatment on microfilariae and antigen levels and adult worms. The study was conducted in 16 dogs as two separate replicates at different times. A total of five dogs (two in Replicate A and three in Replicate B) infected either by SC injection of L3 or intravenous transplantation of adult heartworms were given doxycycline orally at 10mg/kg twice daily for 30 days, with three untreated controls. Microfilarial counts in the five treated dogs gradually declined during the 12-13 months after treatment initiation. Two dogs were amicrofilaremic before necropsy and three had 13 or fewer microfilariae/ml. Only one treated dog was negative for heartworm antigen before necropsy. Overall, treated dogs generally had fewer live adult heartworms than controls, and most of their live worms were moribund. All three control dogs remained positive for microfilariae and antigen and had many live worms. L3 from mosquitoes fed on blood collected 73-77 or 161-164 days after initiation of doxycycline treatments were injected SC into five dogs. None of the dogs injected with L3 from mosquitoes fed on blood from doxycycline-treated dogs were ever positive for microfilariae or antigen, and none had worms at necropsy; three control dogs were positive for microfilariae and antigen and had many live worms. These data indicate that doxycycline treatment of microfilaremic dogs gradually reduces numbers of microfilariae and blocks further transmission of heartworms. This latter effect should be highly effective in reducing the rate of selection of heartworms with genes that confer resistance to macrocyclic lactone preventives and microfilaricides. The data also suggest that doxycycline has a slow-kill effect on adult heartworms. PMID:25458121

McCall, J W; Kramer, L; Genchi, C; Guerrero, J; Dzimianski, M T; Mansour, A; McCall, S D; Carson, B

2014-11-15

84

Black-Tailed Prairie Dog  

USGS Multimedia Gallery

Black-tailed prairie dogs are quite susceptible to sylvatic plague, but a new plague vaccine put in their food shows significant promise in the laboratory. The prairie dogs transmit the disease to endangered black-footed ferrets, who eat the prairie dogs and are also quite susceptible to the disease...

85

Facial dog attack injuries.  

PubMed

The exposed position of the face makes it vulnerable to dog bite injuries. This fact combined with the short stature of children makes them a high-risk group for such attacks. In contrast to wounds inflicted by assaults and accidents, dog bite wounds are deep puncture type wounds compounded by the presence of pathologic bacteria from the saliva of the attacking dog. This, combined with the presence of crushed, devitalized tissue makes these wounds highly susceptible to infection. Key to successful management of such wounds are meticulous cleansing of the wound, careful debridement, primary repair, appropriate antibiotic therapy, and rabies and tetanus immunization where indicated. This review presents an overview of the epidemiology, presentation, management of such emergencies, and the recent advances in the care of such patients. PMID:25829713

Lin, Wei; Patil, Pavan Manohar

2015-02-01

86

Molecular diagnosis of diphyllobothriasis in Spain, most presumably acquired via imported fish, or sojourn abroad  

PubMed Central

Human diphyllobothriasis is sporadically detected in Spain. Diphyllobothrium latum and Diplogonoporus balaenopterae have been identified. In the study, four cases of presumably imported diphyllobothriasis in Spanish patients were appraised. Molecular diagnosis allowed us to identify ‘exotic’ fish tapeworms such as Diplogonoporus balaenopterae in one patient and Diphyllobothrium pacificum in the others. PMID:25356331

Pastor-Valle, J; González, L M; Martín-Clemente, J P; Merino, F J; Gottstein, B; Gárate, T

2014-01-01

87

Technology to enhance learning Throughout history, presumably starting with charcoal. But  

E-print Network

Learning and the World­Wide Web: A Status Report by Professor Albert R. Meyer Hitachi America Professor3 Technology to enhance learning Throughout history, presumably starting with charcoal Conference on Technology in Collegiate Math (New Orleans) 300 talks on (1) setting up course web pages (2) TI

Polz, Martin

88

Prehospital use of continuous positive airway pressure (CPAP) for presumed pulmonary edema: A preliminary case series  

Microsoft Academic Search

Objective. To describe the prehospital use of a continuous positive airway pressure (CPAP) system for the treatment of acute respiratory failure presumed to be due to cardiogenic pulmonary edema. Methods. Prospective case-series analysis. Paramedics administered CPAP via face mask at 10 cm H2O to patients believed to be in cardiogenic pulmonary edema and in imminent need of endotracheal intubation (ETI).

Joshua M. Kosowsky; Steven L. Stephanides; Richard D. Branson; Michael R. Sayre

2001-01-01

89

28 CFR 104.45 - Determination of presumed economic loss for claimants who suffered physical harm.  

Code of Federal Regulations, 2010 CFR

...economic loss for claimants who suffered physical harm. 104.45 Section 104.45...economic loss for claimants who suffered physical harm. In reaching presumed determinations...economic loss for claimants who suffered physical harm (but did not die), the...

2010-07-01

90

Presumed Perinatal Stroke in a Child with Down Syndrome and Moyamoya Disease  

ERIC Educational Resources Information Center

Moyamoya disease describes a cerebral arteriopathy characterized by stenosis or occlusion of the terminal internal carotid and/or the proximal middle cerebral arteries. We report a female child with trisomy 21 and bilateral moyamoya disease who presented, unusually, with a presumed perinatal cerebral infarct. The clinical, radiological, and…

Pysden, Karen; Fallon, Penny; Moorthy, Bhagavatheswaran; Ganesan, Vijeya

2010-01-01

91

718 Book Reviews public' (p. vii) and one presumably to a more scholarly audience. This history  

E-print Network

718 Book Reviews public' (p. vii) and one presumably to a more scholarly audience. This history). Of course, every book must treat some things more painstakingly than others. But scholars, at any rate to obscure the book's undeni- able merits. It is an important work, which should interest and stimulate

Fitelson, Branden

92

Host-related fitness trade-offs in a presumed generalist parasitoid, Diaeretiella rapae (Hymenoptera: Aphidiidae)  

E-print Network

Host-related fitness trade-offs in a presumed generalist parasitoid, Diaeretiella rapae in Diaeretiella rapae (Hymenoptera: Aphidiidae), which has been described as a generalist that attacks more than brassicae) and Russian wheat aphid (Diuraphis noxia). Here, labora- tory experiments are described in which

Antolin, Michael F.

93

Actin pegs and ultrastructure of presumed sensory receptors of Beroë (Ctenophora)  

Microsoft Academic Search

We have investigated the actin content and ultrastructure of two kinds of presumed sensory projections on the lip epidermis of beroid ctenophores. Transmission electron microscopy showed that conical pegs contain a large bundle of densely packed, parallel microfilaments. Rhodamine-phalloidin brightly stained the pegs, confirming that they contain filamentous actin. Epidermal cells with actin pegs also bear a single long cilium

Signhild Tamm; Sidney Tamm

1991-01-01

94

Zen Hot Dog Molecules  

ERIC Educational Resources Information Center

Substituted cycloalkanes with one branch illustrating each topic in an instructional unit can serve as summaries or reviews in courses of organic chemistry. The hungry Zen master told the hot dog vendor to make him one with everything. You can do the same for your students.

Ryan, Dennis

2009-01-01

95

Protothecosis in a dog  

PubMed Central

A case of a disseminated algal infection is reported in a young rough-coated collie dog with progressive neurologic deficits, blindness, and hemorrhagic diarrhea. Prototheca zopfii organisms were cultured from feces, urine, and blood. At necropsy, granulomas containing typical organisms were identified within the proximal colon, heart, kidneys, and eyes. PMID:25320382

Vince, Andrew R.; Pinard, Chantale; Ogilvie, Adam T.; Tan, Emmeline O.; Abrams-Ogg, Anthony C.G.

2014-01-01

96

Dog Bite Emergencies  

MedlinePLUS

... server. Please enable scripts and reload this page. Contact | Join | Store | Career Center | Sign In View Mobile Site Member Center My Profile Join the AVMA ... Educators You are here: Home | Public ... should do: If the dog's owner is present, request proof of rabies vaccination, and get the owner's name and contact information. Clean bite wound with soap and water ...

97

The Black Dog Mystery  

Microsoft Academic Search

The black dog - a term for depression which has very old origins, but which has been made famous in more recent times by Britain's World War II leader, Sir Winston Churchill, referring to his own periods of gloom. Sir Winston was a great rhetorician, but he did not invent the term. Schooled in the classics as he and his

Sue Hanley

98

Neosporosis in dogs  

Technology Transfer Automated Retrieval System (TEKTRAN)

Neospora caninum is a protozoan parasite of animals. Until 1988, it was misdiagnosed as Toxoplasma gondii. Since its first recognition in 1984 and the description of a new genus and species Neospora caninum in 1988, neosporosis has emerged as a serious disease of dogs and cattle worldwide. Additiona...

99

Glow Dog Glow  

E-print Network

Broadcast Transcript: South Korean researchers, ever striving to be top in science, have cloned a glow-in-the-dark dog. The little beagle was engineered by inserting genes from species--like jellyfish--that produce fluorescent proteins. The gene...

Hacker, Randi

2011-08-17

100

Dogs and Their Owners  

NSDL National Science Digital Library

If you look at drawings of people and their dogs, you'll notice they're often drawn alike: for instance, saggy-faced bulldogs with saggy-faced old men. But is the stereotype really true? A recent study looked into it.

Science Update

2004-05-03

101

Hot Dog Champ Defeated  

E-print Network

Broadcast Transcript: Arthritic jaw? Recent wisdom tooth extraction? The universe saying "It is time"? Whatever. All we know is that Japan's six year domination of Nathan's Famous July 4th Hot Dog Eating contest at Coney Island came to an end...

Hacker, Randi; Tsutsui, William; Bleier, R.H.

2007-07-25

102

Cancer-Sniffing Dogs  

NSDL National Science Digital Library

Cancer-Sniffing Dogs is a Science Update which gives introduces the concept that diseases might be identified by examining the chemicals which are on a patients breath. A more in depth discussion of disease diagnosis by sampling a patients breath is given as well as links to other articles further reading.

American Association for the Advancement of Science (; )

2006-02-10

103

Factors Involved in Search Dog Training  

E-print Network

area and allowed to 16 watch subsequent teammates using that dog?s toy reward to reward their dogs at the target odor. Eventually the handler takes the dog out of the kennel and attempts the training scenario again. If the dog goes...

Alexander, Michael B.

2010-07-14

104

Secondary hemophagocytic lymphohistiocytosis (HLH) from a presumed brown recluse spider bite.  

PubMed

Systemic loxoscelism is a rare complication after Loxosceles reclusa (brown recluse spider) envenomation. Loxosceles venom contains pro-inflammatory proteins, which have been shown to be elevated in patients with hemophagocytic lymph histiocytosis. We present a case of a 10-year-old male that developed presumed systemic loxoscelism, secondary hemophagocytic lymphohistiocytosis with hepatic dysfunction and renal failure. He was treated with dexamethasone and made a full recovery. PMID:24737162

Dandoy, Christopher; Grimley, Michael

2014-07-01

105

Original article Immune responses in vaccinated dogs  

E-print Network

Original article Immune responses in vaccinated dogs with autoclaved Leishmania major promastigotes. The cellular immune response was evaluated by the lymphocyte transformation test. Dogs vacci- nated blotting. However, the lymphocyte proliferation of these dogs to the crude L. infantum antigen

Paris-Sud XI, Université de

106

New Hampshire Guide 4-H Dog Shows  

E-print Network

New Hampshire Guide to 4-H Dog Shows UNH Cooperative Extension 4-H Youth Development Moiles House cooperating. #12;NH Guide to 4-H Dog Shows i Table of Contents INTRODUCTION .................................................................................................................................2 Purpose of the 4-H Dog Project

New Hampshire, University of

107

Dog Flu Outbreak Unleashes Warnings from Veterinarians  

MedlinePLUS

... sharing features on this page, please enable JavaScript. Dog Flu Outbreak Unleashes Warnings From Veterinarians Pay attention ... 2015 (HealthDay News) -- With more than 1,000 dogs sickened by a highly contagious dog flu in ...

108

Collection Development "Dog Care & Training": The Well-Behaved Dog  

ERIC Educational Resources Information Center

Dogs are indeed people's best friends. A majority of owners report that their dog is a "member of the family," and that acceptable canine behavior and optimal care are high priorities for them. The human-animal bond, the close connection between people and their pets, is forged by positive interactions, but unacceptable canine behaviors that…

Alpi, Kristine M.; Sherman, Barbara L.

2008-01-01

109

Atypical caudal duplication with phenotypic sex reversal in a dog.  

PubMed

A male German Shepherd Dog mix was presented for chronic non-weight-bearing lameness of the left hind limb. At clinical examination, the dog's left hind limb had severe joint contractures, with the presence of what appeared to be a second paw. The dog also had 2 sets of external genitalia of opposite phenotypic sex; a complete male reproductive tract with a left retained testicle and a right descended testicle, as well as rudimentary female external genitalia including a hypoplastic vulva with a blind-end vagina and a hypertrophied clitoris. The female genitalia were located on the proximal posterior third of the deformed limb. Following amputation of the hind limb, gross pathologic analysis revealed a duplication of the fibula, tarsal, and metatarsal bones, digits, and appendices. The supernumerary structures and female genitalia were concluded to represent a parasitic twin. As conjoined or parasitic twinning of non-identical twins is thought to be impossible, the presence of genitalia of opposite phenotypic sex appeared paradoxical. Polymerase chain reaction analyses were therefore performed to determine the genotypic sex of both animals, which revealed the presence of the Y chromosome in all tissues, including the female genitalia. The non-masculinization of the external genitalia in the parasitic twin was presumed to be the result of an embryonic developmental defect. On this basis, a diagnosis of atypical caudal duplication (parasitic twinning) with phenotypic sex reversal was made. PMID:21908371

Paquet, Marilčne; El-Warrak, Alexander O; Laguë, Marie-Noëlle; Boerboom, Derek

2011-09-01

110

Disseminated oligodendroglial-like leptomeningeal tumor with anaplastic progression and presumed extraneural disease: case report.  

PubMed

We report the neuroimaging and histopathologic findings of a 12-year-old female patient with a disseminated oligodendroglial-like leptomeningeal tumor with anaplastic progression and presumed extraneural metastatic disease. These tumors may represent distinct pathology primarily seen in pediatric patients. Neuroimaging demonstrates diffuse, progressive enhancement of the leptomeninges often with interval development of intraparenchymal lesions on follow-up. Disease is typically confined to the central nervous system, though diffuse peritoneal disease was seen in our case, possibly through metastatic seeding of the abdomen via ventriculoperitoneal shunt. PMID:25518979

Kessler, Brice A; Bookhout, Christine; Jaikumar, Sivakumar; Hipps, John; Lee, Yueh Z

2015-01-01

111

Do Dog Behavioral Characteristics Predict the Quality of the Relationship between Dogs and Their Owners?  

PubMed Central

This paper explores whether dog behavioral characteristics predict the quality of the relationship between dogs and their owners (i.e., owner attachment to dog), and whether relations between dog behavior and owner attachment are moderated by demographic characteristics. In this study, N = 92 children and N = 60 adults from 60 dog-owning families completed questionnaires about their attachment to their pet dog, their level of responsibility for that dog, and their general attitudes toward pets. They also rated their dogs on observable behavioral characteristics. Individuals who held positive attitudes about pets and who provided much of their dog’s care reported stronger attachments to their dogs. The strength of owners’ attachments to their dogs was associated with dog trainability and separation problems. Relationships between owner attachment and both dog excitability and attention-seeking behavior were further moderated by demographic characteristics: for Caucasians but not for non-Caucasians, dog excitability was negatively associated with owner attachment to dog; and for adults, dog attention-seeking behavior was positively associated with owner attachment, but children tended to be highly attached to their dogs, regardless of their dogs’ attention-seeking behaviors. This study demonstrates that certain dog behavioral traits are indeed associated with the strength of owners’ attachments to their dogs. PMID:25685855

Hoffman, Christy L.; Chen, Pan; Serpell, James A.; Jacobson, Kristen C.

2014-01-01

112

Prairie Dog Released from Trap  

USGS Multimedia Gallery

A prairie dog returns to its burrow in Wind Cave National Park after scientists free it from a trap. The animal is part of a field test to determine the effectiveness of a USGS-developed oral sylvatic plague vaccine (SPV). This prairie dog was previously tagged, and its blood, hair, and whisker samp...

113

Inflammatory autoimmune neuropathy, presumably induced by bortezomib, in a patient suffering from multiple myeloma.  

PubMed

Bortezomib is a proteasome inhibitor demonstrating substantial activity in multiple myeloma. One of its key toxicities is peripheral neuropathy, which is reversible in most patients. The possibility that bortezomib might in rare cases induce severe neuropathies by auto-inflammatory mechanisms remains controversial. We report here the case of a 65-year-old female myeloma patient who was initially treated with bortezomib, doxorubicin, and dexamethasone (PAD). At the end of the second cycle of PAD, the patient presented with a rapid and severe onset of paresis of the left arm, accompanied by progressive sensory neuropathy and increasing neuropathic pain. After an extensive neurological work-up, including electrophysiological and laboratory evaluations as well as magnet resonance tomography imaging, we diagnosed an inflammatory autoimmune neuropathy, presumably induced by bortezomib, with accentuation of the left arm nerve plexus. We subsequently initiated regular treatment with polyvalent immunoglobulins, which gradually improved the neurological symptoms. In conclusion, the identification of an inflammatory autoimmune neuropathy, presumably associated with bortezomib, is a rare but important complication. An extensive neurological examination should be performed in patients who develop severe or unusual sensory or motor deficits under therapy with bortezomib, so as to differentiate autoimmune from toxic neuropathies, as therapeutic strategies differ for each. PMID:21553020

Schmitt, Stefan; Goldschmidt, H; Storch-Hagenlocher, B; Pham, M; Fingerle-Rowson, G; Ho, A D; Neben, K

2011-06-01

114

A service dog in group.  

PubMed

Service dogs are sanctioned by the Americans with Disabilities Act as having protected rights allowing them to assist owners with disabilities. These dogs are appearing with increasing frequency in healthcare settings, and it is important for healthcare providers to understand the rules and regulations given to service animals and owners. We discuss processes that transpired when a service dog was brought into a psychodynamic psychotherapy group. The purpose of this paper is to highlight the unintended consequences of the Americans with Disabilities Act of 2010 as it concerns service dogs and the impact on the group process. Problems resulting from the introduction of service dogs into therapy groups should be anticipated and explicitly discussed in the course of the group's transactions. PMID:25760790

Rothberg, Brian; Collins, Emily

2015-04-01

115

Rotary slot dog  

DOEpatents

A clamp or dog is disclosed which preferably comprises a slotted stepped cylindrical body which is inserted into a hole in a workpiece and then fastened to a base or fixture using a screw which is inserted through the slot. The stepped configuration provides an annular clamping surface which securely clamps the workpiece against the base or fixture. The slotted cylindrical configuration permits adjustment of the workpiece and retaining clamp in any direction, i.e., over 360.degree., relative to the mounting position of the screw in the base or fixture.

Cutburth, Ronald W. (Tracy, CA); Smauley, David A. (Livermore, CA)

1987-01-01

116

Functional MRI in Awake Unrestrained Dogs  

Microsoft Academic Search

Because of dogs' prolonged evolution with humans, many of the canine cognitive skills are thought to represent a selection of traits that make dogs particularly sensitive to human cues. But how does the dog mind actually work? To develop a methodology to answer this question, we trained two dogs to remain motionless for the duration required to collect quality fMRI

Gregory S. Berns; Andrew M. Brooks; Mark Spivak

2012-01-01

117

Dog Obedience, Showmanship, and Contest Guide  

E-print Network

Dog Obedience, Showmanship, and Contest Guide 4-H 1202 Revised January 2013 Purpose Obedience and showmanship contests provide an opportunity for you to demonstrate how well you've trained your dog and how you and your dog work as a team. Eligibility You may enter 4-H dog obedience and showmanship trials

New Hampshire, University of

118

Correspondence Dog as an Outgroup to Human  

E-print Network

Correspondence Dog as an Outgroup to Human and Mouse Gerton Lunter In a recent contribution to PLo to human and dog [1], in disagreement with several recent studies suggesting that the dog is an outgroup to the primate­rodent clade [2,3]. The authors' arguments rest on a variety of analyses of human, mouse, and dog

Gerstein, Mark

119

The Human Role in Dog Evolution  

NSDL National Science Digital Library

This lesson plan asks students to investigate and think carefully about the human role in the domestication and evolution of ancient and modern dog breeds. Students will explore the relationship between wolves and dogs, the reasons why dogs have been bred, and the controversial wolf hybrid breed. They will conclude by writing essays explaining the role of humans in dog evolution, past and present.

120

Presumed immune-mediated cerebellar granuloprival degeneration in the Coton de Tuléar breed.  

PubMed

An unusual form of cerebellar granuloprival degeneration was observed in three male Coton de Tuléar puppies between 12 and 14 weeks of age from different litters showing progressive cerebellar signs beginning at 8 weeks after birth. Pathological examinations revealed a shrunken cerebellum. Histopathologically the granular cells were diminished or almost completely absent, some 'torpedos' of Purkinje cells were present. There was a marked gliosis, and occasionally small inflammatory foci were present. A marked diffuse T cell infiltration (CD3(+) cells) occurred in the lesions, B cells did not appear. CD18 staining showed an upregulation of microglial cells at the lesion site. Histopathologically the lesions resembled paraneoplastic cerebellar degeneration which is caused by an autoimmune mediated T cell reaction. This congenital condition in the Coton de Tuléar dog breed could be based on a genetically defined immune defect leading to autoimmune destruction of the granular cells. PMID:11024542

Tipold, A; Fatzer, R; Jaggy, A; Moore, P; Vandevelde, M

2000-10-01

121

Complex population structure in African village dogs and its implications for inferring dog domestication history  

PubMed Central

High genetic diversity of East Asian village dogs has recently been used to argue for an East Asian origin of the domestic dog. However, global village dog genetic diversity and the extent to which semiferal village dogs represent distinct, indigenous populations instead of admixtures of various dog breeds has not been quantified. Understanding these issues is critical to properly reconstructing the timing, number, and locations of dog domestication. To address these questions, we sampled 318 village dogs from 7 regions in Egypt, Uganda, and Namibia, measuring genetic diversity >680 bp of the mitochondrial D-loop, 300 SNPs, and 89 microsatellite markers. We also analyzed breed dogs, including putatively African breeds (Afghan hounds, Basenjis, Pharaoh hounds, Rhodesian ridgebacks, and Salukis), Puerto Rican street dogs, and mixed breed dogs from the United States. Village dogs from most African regions appear genetically distinct from non-native breed and mixed-breed dogs, although some individuals cluster genetically with Puerto Rican dogs or United States breed mixes instead of with neighboring village dogs. Thus, African village dogs are a mosaic of indigenous dogs descended from early migrants to Africa, and non-native, breed-admixed individuals. Among putatively African breeds, Pharaoh hounds, and Rhodesian ridgebacks clustered with non-native rather than indigenous African dogs, suggesting they have predominantly non-African origins. Surprisingly, we find similar mtDNA haplotype diversity in African and East Asian village dogs, potentially calling into question the hypothesis of an East Asian origin for dog domestication. PMID:19666600

Boyko, Adam R.; Boyko, Ryan H.; Boyko, Corin M.; Parker, Heidi G.; Castelhano, Marta; Corey, Liz; Degenhardt, Jeremiah D.; Auton, Adam; Hedimbi, Marius; Kityo, Robert; Ostrander, Elaine A.; Schoenebeck, Jeffrey; Todhunter, Rory J.; Jones, Paul; Bustamante, Carlos D.

2009-01-01

122

Vanishing native American dog lineages  

Microsoft Academic Search

Background  Dogs were an important element in many native American cultures at the time Europeans arrived. Although previous ancient DNA\\u000a studies revealed the existence of unique native American mitochondrial sequences, these have not been found in modern dogs,\\u000a mainly purebred, studied so far.\\u000a \\u000a \\u000a \\u000a \\u000a Results  We identified many previously undescribed mitochondrial control region sequences in 400 dogs from rural and isolated areas\\u000a as

Santiago Castroviejo-Fisher; Pontus Skoglund; Raúl Valadez; Carles Vilŕ; Jennifer A Leonard

2011-01-01

123

Pemphigus foliaceus in 91 dogs.  

PubMed

A retrospective study of 91 dogs with pemphigus foliaceus was performed. Clinical signs of the disease included crusts (n=79), pustules (n=36), and alopecia (n=33). Lesions were most common on the trunk (n=53), inner pinnae (n=46), face (n=37), and foot pads (n=32). Cytological evaluation revealed acantholytic keratinocytes in 37 of 48 dogs. Results of combination treatment with prednisolone and azathioprine were comparable to results with prednisolone therapy alone. More than half of the dogs achieved remission with appropriate therapy, and another 25% significantly improved. PMID:16611930

Mueller, Ralf S; Krebs, Ingar; Power, Helen T; Fieseler, Kathryn V

2006-01-01

124

Hybrid presumed pdf and flame surface density approaches for Large-Eddy Simulation of premixed turbulent combustion  

Microsoft Academic Search

Extended Coherent Flame Model for Large-Eddy Simulation (ECFM-LES) and Presumed Conditional Moments-Flame Prolongation of Intrisic Low Dimensional Manifolds (PCM-FPI) are some of the combustion models exploited for Large-Eddy Simulations (LES) of turbulent premixed flames. Combustion is then either modeled by tracking the flame surface density or by combining computations of flamelets with presumed probability density functions (pdf). The first approach

Guillaume Lecocq; Stéphane Richard; Olivier Colin; Luc Vervisch

2011-01-01

125

A PCR study of piroplasms in 166 dogs and 111 horses in France (March 2006 to March 2008).  

PubMed

Positive PCR results for piroplasms were obtained on EDTA blood samples from 166 dogs and 111 horses between March 2006 and March 2008. The organisms were initially identified using common primers, followed by restriction enzyme profiles to determine the species and types of Babesia/Theileria. In 27 dogs and eight horses with positive results, the size of the specimen was insufficient to separate species/types. We identified Babesia canis canis in 105 of the 166 dogs (63%) and Theileria equi in 89 of the 111 horses (80%). Babesia caballi was also present, but rare, in only two Babesia/Theileria of the 111 horses (1.2%). Unexpected findings were the identification of T. equi in 31 of the 166 dogs (19%), of B. caballi in one of the 166 dogs (0.6%), of B. canis canis in 11 of 111 horses (10%), as well as of Babesia canis rossi in one of 111 horses (0.9%). A positive result for B. canis rossi was also obtained in one of the 166 dogs (0.6%). A single case of the California type of "Babesia gibsoni" (presumably Babesia conradae) was found in a dog. We did not detect Babesia canis vogeli, possibly because of the geographic distribution of our clients. The unusual results were confirmed by DNA sequencing in several cases for B. canis canis and B. canis rossi in horses, as well as T. equi in dogs. Such infections might explain the difficulties met in some unsuccessfully treated animals using the standard dosage of imidocarb dipropionate at 3 mg/kg in dogs. PMID:20221639

Fritz, Denis

2010-05-01

126

76 FR 35162 - Service Dogs  

Federal Register 2010, 2011, 2012, 2013, 2014

...dogs for the aid of persons with mental illnesses by amending section 1714. Although...veterans diagnosed with certain mental illness, at this time we do not have...appropriately provided to veterans with mental illness, including post-...

2011-06-16

127

Treating Cushing's Disease in Dogs  

MedlinePLUS

... body produces too much of a hormone called cortisol. Cortisol is produced and stored by the adrenals, two ... found in dogs than in cats or horses. "Cortisol is one of the body's natural steroids," says ...

128

Consenting options for posthumous organ donation: presumed consent and incentives are not favored  

PubMed Central

Background Posthumous organ procurement is hindered by the consenting process. Several consenting systems have been proposed. There is limited information on public relative attitudes towards various consenting systems, especially in Middle Eastern/Islamic countries. Methods We surveyed 698 Saudi Adults attending outpatient clinics at a tertiary care hospital. Preference and perception of norm regarding consenting options for posthumous organ donation were explored. Participants ranked (1, most agreeable) the following, randomly-presented, options from 1 to 11: no-organ-donation, presumed consent, informed consent by donor-only, informed consent by donor-or-surrogate, and mandatory choice; the last three options ± medical or financial incentive. Results Mean(SD) age was 32(9) year, 27% were males, 50% were patients’ companions, 60% had???college education, and 20% and 32%, respectively, knew an organ donor or recipient. Mandated choice was among the top three choices for preference of 54% of respondents, with an overall median[25%,75%] ranking score of 3[2,6], and was preferred over donor-or-surrogate informed consent (4[2,7], p?presumed consent (7[3,10], p?presumed consent system was the least preferred, 3) there was no difference between preference and perception of norm in consenting systems ranking, and 4) financial (especially in females) and medical (especially in males) incentives reduced preference. PMID:23173834

2012-01-01

129

Why do adult dogs 'play'?  

PubMed

Among the Carnivora, play behaviour is usually made up of motor patterns characteristic of predatory, agonistic and courtship behaviour. Domestic dogs are unusual in that play is routinely performed by adults, both socially, with conspecifics and with humans, and also asocially, with objects. This enhanced playfulness is commonly thought to be a side effect of paedomorphosis, the perpetuation of juvenile traits into adulthood, but here we suggest that the functions of the different types of play are sufficiently distinct that they are unlikely to have arisen through a single evolutionary mechanism. Solitary play with objects appears to be derived from predatory behaviour: preferred toys are those that can be dismembered, and a complex habituation-like feedback system inhibits play with objects that are resistant to alteration. Intraspecific social play is structurally different from interspecific play and may therefore be motivationally distinct and serve different goals; for example, dogs often compete over objects when playing with other dogs, but are usually more cooperative when the play partner is human. The majority of dogs do not seem to regard competitive games played with a human partner as "dominance" contests: rather, winning possession of objects during games appears to be simply rewarding. Play may be an important factor in sociality, since dogs are capable of extracting social information not only from games in which they participate, but also from games that they observe between third parties. We suggest that the domestic dog's characteristic playfulness in social contexts is an adaptive trait, selected during domestication to facilitate both training for specific purposes, and the formation of emotionally-based bonds between dog and owner. Play frequency and form may therefore be an indicator of the quality of dog-owner relationships. PMID:25251020

Bradshaw, John W S; Pullen, Anne J; Rooney, Nicola J

2015-01-01

130

Circadian timekeeping in narcoleptic dogs.  

PubMed

Anatomical and functional aspects of the circadian timekeeping system containing the suprachiasmatic nucleus (SCN) were compared in normal and genetically narcoleptic dogs. The retinohypothalamic tract was delineated by tritiated amino acid autoradiography, the SCN was identified and examined by morphological techniques, and the circadian rhythm of melatonin concentrations in cerebrospinal fluid was measured by radioimmunoassay. Results suggest that the retinal input, cytoarchitecture, and essential timekeeping function of the SCN are intact in narcoleptic dogs. PMID:3704434

Schwartz, W J; Morton, M T; Williams, R S; Tamarkin, L; Baker, T L; Dement, W C

1986-01-01

131

Testosterone and 5HIAA in dogs with intraspecific aggression  

E-print Network

Intraspecific aggression is a common problem in dogs, with such aggression typically due to dominance, fear, and/or territoriality. Some dogs appear to perceive the mere presence of another dog as a challenge or threat. These dogs often show...

Haug, Lore I

2003-01-01

132

Dog Bites: How to Teach Your Children to Be Safe  

MedlinePLUS

... To learn about dog breeds, talk with a veterinarian, read books about dogs and search the Internet. ... date. Have your dog checked regularly by a veterinarian. What do I tell my children about dogs? ...

133

ORIGINAL CONTRIBUTION Bilateral Horizontal Gaze Palsy in Presumed Paraneoplastic Brainstem Encephalitis Associated With a  

E-print Network

Abstract: A 28-year-old woman with a previous history of recurrent benign ovarian teratoma developed a bilateral horizontal gaze palsy, a right facial paresis, and bilateral trigeminal hypesthesia. Magnetic resonance imaging dis-closed high signal in the rostral pons. Results of all other laboratory studies, including those for antineuronal anti-bodies (anti-Hu, anti-Yo, anti-Ri, anti-Tr, anti-Ma1, anti-Ma2, and anti-CV2/CRMP5), were negative. Pelvic ultra-sound revealed a residual mass in the left ovary, which was confirmed as teratoma on surgical pathological examina-tion. Complete neurologic recovery occurred within two weeks of surgical removal of the teratoma and treatment with intravenous corticosteroids and immunoglobulin. This case demonstrates that a search for an occult neoplasm is extremely important in the diagnosis of presumed paraneo-plastic encephalitis even if antineuronal antibodies are not found. (J Neuro-Ophthalmol 2004;24: 114–118) Paraneoplastic syndromes are remote effects of cancerthat are not directly related to tumor growth, metastases, metabolic or nutritional derangements, or side effects of therapy. The clinical manifestations of a paraneoplastic process are often the first presentation of an underlying tu-mor (1). Paraneoplastic encephalomyelitis–sensory neu-ronopathy (PEM-SN) is a well-characterized syndrome that is typically irreversible and most commonly associated with small-cell lung cancer and anti-Hu antibodies (2). The clinical manifestations are variable, including multifocal involvement of the central or peripheral nervous system or both, and brainstem or limbic encephalitis. There are a few case reports of supranuclear, nuclear, or internuclear ocular motor abnormalities affecting horizontal or vertical eye movements or both in patients with PEM-SN (3–8). We re-port a case of complete bilateral horizontal gaze palsy in a patient with a presumed paraneoplastic brainstem encepha-litis associated with a benign ovarian teratoma. Surgical re-moval of the tumor, combined with intravenous corticoste-roid and immunoglobulin treatment, rapidly reversed all neuro-ophthalmic manifestations.

Benign Ovarian Teratoma; Agnes M. F. Wong

134

Outcome of occult uterine leiomyosarcoma after surgery for presumed uterine fibroids: a systematic review.  

PubMed

There is concern that morcellation of occult leiomyosarcomas during surgery to treat presumed myomas may substantially worsen patient outcome. We reviewed the existing medical literature to better understand whether such a risk was demonstrable and, if so, what the magnitude of that risk might be. We identified 4864 articles initially, of which 60 were evaluated in full. Seventeen were found to have outcomes information and are included in this review. Six studies addressed the question of whether morcellation of occult leiomyosarcomas resulted in inferior outcomes as compared with en bloc uterine and tumor removal. In these 6 studies, results suggested that en bloc removal may result in improved survival and less recurrence; however, the data are highly biased and of poor quality. There is no reliable evidence that morcellation, power or otherwise, substantially results in tumor upstaging. There is no evidence from these 17 studies that power morcellation differs in any way from other types of morcellation or even simple myomectomy insofar as patient outcome. Whether electromechanical morcellation poses a unique danger to the patient with occult leiomyosarcoma is an unanswered question and one clearly in need of more extensive investigation before conclusions are drawn and policies created. PMID:25193444

Pritts, Elizabeth A; Parker, William H; Brown, Jubilee; Olive, David L

2015-01-01

135

Presumed toxoplasmic central retinal artery occlusion and multifocal retinitis with perivascular sheathing  

PubMed Central

Central retinal artery occlusion (CRAO) and multifocal retinitis with perivascular sheathing are rare in ocular toxoplasmosis. We report a case of toxoplasmic CRAO and multifocal retinitis with perivascular sheathing. A healthy 83-year-old male developed left panuveitis. Funduscopic examination of the left eye showed a swollen optic disc and sheathing of the retinal artery with a dense vitreous haze and a white retinal lesion. Serum anti-toxoplasma antibodies were positive in a latex agglutination assay. Vitrectomy was performed to improve visualization of the retinal lesions and for examination of causative microorganisms. A postoperative fundus examination revealed CRAO with optic disc involvement and multifocal retinitis with perivascular sheathing. Qualitative multiplex polymerase chain reaction detected the Toxoplasma gondii B1 gene in ocular fluid from both the aqueous and vitreous humor. The presumed diagnosis of ocular toxoplasmosis was made and treatment was started with prednisone and acetylspiramycin with subsequent improvement. Two months later, the patient developed active retinochoroiditis in the left eye. After 6 weeks of anti-toxoplasma therapy, the disease involuted. Retinal vascular occlusions and multifocal retinitis with perivascular sheathing are rare in toxoplasmosis. This is the first case report of toxoplasmic CRAO and multifocal retinitis with perivascular sheathing. The diagnosis of ocular toxoplasmosis should be considered in patients with retinal artery occlusions and multifocal retinitis with perivascular sheathing associated with inflammation. PMID:24790408

Arai, Haruka; Sakai, Tsutomu; Okano, Kiichiro; Aoyagi, Ranko; Imai, Ayano; Takase, Hiroshi; Mochizuki, Manabu; Tsuneoka, Hiroshi

2014-01-01

136

Excimer Laser Phototherapeutic Keratectomy for the Treatment of Clinically Presumed Fungal Keratitis  

PubMed Central

This retrospective study was to evaluate treatment outcomes of excimer laser phototherapeutic keratectomy (PTK) for clinically presumed fungal keratitis. Forty-seven eyes of 47 consecutive patients underwent manual superficial debridement and PTK. All corneal lesions were located in the anterior stroma and were resistant to medication therapy for at least one week. Data were collected by a retrospective chart review with at least six months of follow-up data available. After PTK, infected corneal lesions were completely removed and the clinical symptoms resolved in 41 cases (87.2%). The mean ablation depth was 114.39 ± 45.51??m and diameter of ablation was 4.06 ± 1.07?mm. The mean time for healing of the epithelial defect was 8.8 ± 5.6 days. Thirty-four eyes (82.9%) showed an improvement in best spectacle-corrected visual acuity of two or more lines. PTK complications included mild to moderate corneal haze, hyperopic shift, irregular astigmatism, and thinning cornea. Six eyes (12.8%) still showed progressed infection, and conjunctival flap covering, amniotic membrane transplantation, or penetrating keratoplasty were given. PTK is a valuable therapeutic alternative for superficial infectious keratitis. It can effectively eradicate lesions, hasten reepithelialization, and restore and preserve useful visual function. However, the selection of surgery candidates should be conducted carefully. PMID:24891945

Li, Liang-Mao; Zhao, Li-Quan; Qu, Ling-Hui; Li, Peng

2014-01-01

137

A discussion supporting presumed consent for posthumous sperm procurement and conception.  

PubMed

Conception of a child using cryopreserved sperm from a deceased man is generally considered ethically sound provided explicit consent for its use has been made, thereby protecting the man's autonomy. When death is sudden (trauma, unexpected illness), explicit consent is not possible, thereby preventing posthumous sperm procurement (PSP) and conception according to current European Society of Human Reproduction and Embryology and the American Society for Reproductive Medicine guidelines. Here, we argue that autonomy of a deceased person should not be considered the paramount ethical concern, but rather consideration of the welfare of the living (widow and prospective child) should be the primary focus. Posthumous conception can bring significant advantages to the widow and her resulting child, with most men supporting such practice. We suggest that a deceased man can benefit from posthumous conception (continuation of his 'bloodline', allowing his widow's wishes for a child to be satisfied), and has a moral duty to allow his widow access to his sperm, if she so wishes, unless he clearly indicated that he did not want children when alive. We outline the arguments favouring presumed consent over implied or proxy consent, plus practical considerations for recording men's wishes to opt-out of posthumous conception. PMID:25456161

Tremellen, Kelton; Savulescu, Julian

2015-01-01

138

Comparison of polymerase chain reaction and standard microbiological techniques in presumed bacterial corneal ulcers.  

PubMed

To assess utility of PCR in the diagnosis of bacterial corneal ulcer and to compare sensitivity and specificity of this technique with conventional laboratory methods. A prospective nonrandomized investigative study conducted on 122 eyes of presumed bacterial keratitis. Samples were collected for bacterial and fungal culture and Gram stain smear. A separate sample was taken for PCR with 26 gauge needle and was dipped directly into eppendorff tube with lysis buffer in it. Diagnosis of culture proven bacterial keratitis was established in 53 (43.4 %) and most common bacterial isolate was staphylococcal sp. (83 %). Direct microscopic examination of Gram stained smear revealed presence of bacteria in 24 (23.9 %) specimens and PCR positivity was evident in 56 (45.5 %). In preantibiotic treated eyes culture was positive in 15 (30 %), Gram stain in 9 (18 %), and PCR in 18 (36 %). The same for untreated (fresh) eyes, positivity of culture as well as PCR was noted in 38 (52.7 %) and that of Gram stain was noted in 20 (27.7 %). Sensitivity of Gram stain and PCR was 45.28 and 88.68 % respectively; whereas specificity was 92.75 % for Gram stain and 86.96 % for PCR. The average time taken for PCR reaction was 4-8 h while culture reporting took at least 24-48 h. Our findings suggest that PCR is a good adjunct modality to the "Gold Standard" technique in the diagnosis of bacterial corneal ulcer. PMID:24958188

Panda, Anita; Pal Singh, Tajinder; Satpathy, Geeta; Wadhwani, Meenakshi; Monika Matwani

2015-04-01

139

Analysis of PDE6D and PDE6G genes for generalised progressive retinal atrophy (gPRA) mutations in dogs  

PubMed Central

The ? and ? subunits of the cGMP-phosphodiesterase (PDE6D, PDE6G) genes were screened in order to identify mutations causing generalised progressive retinal atrophy (gPRA) in dogs. In the PDE6D gene, single nucleotide polymorphisms (SNP) were observed in exon 4, in introns 2 and 3 and in the 3' untranslated region (UTR) of different dog breeds. In the coding region of the PDE6G gene, exclusively healthy Labrador Retrievers showed an A ? G transition in exon 4 without amino acid exchange. SNP were also observed in introns 1 and 2 in different dog breeds. The different SNP were used as intragenic markers to investigate the involvement of both genes in gPRA. The informative substitutions allowed us to exclude mutations in the PDE6D and PDE6G genes as causing retinal degeneration in 15 of the 22 dog breeds with presumed autosomal recessively transmitted (ar) gPRA. PMID:12927076

Dekomien, Gabriele; Epplen, Joerg T

2003-01-01

140

VSF Dog Department Entry Form 2014 In order to show your dog(s), you must have completed the Dog Approval/Identification form that was due to your Extension  

E-print Network

VSF Dog Department Entry Form 2014 In order to show your dog(s), you must have completed the Dog BE SUBMITTED FOR EACH DOG YOU'RE ENTERING to the UVM Extension Office, 1 Scale Avenue, Suite 55, Rutland, Vermont 05701-4457 ATTN: VSF Dog Department, or scanned and sent as an attachment to mary

Hayden, Nancy J.

141

Attitudes toward Financial Incentives, Donor Authorization, and Presumed Consent among Next-of-Kin Who Consented vs. Refused Organ Donation  

PubMed Central

Background Financial incentives, donor authorization, and presumed consent are strategies designed to increase organ donation rates. Surveys designed to assess attitudes toward these initiatives have been conducted with the general public, transplant patients, and transplant professionals. Methods To assess attitudes toward financial incentives, donor authorization, and presumed consent and to identify multivariate predictors of such attitudes, we conducted telephone interviews with 561 family members who had recently been asked for consent to donate the organs of a deceased family member (348 donors, 213 nondonors). Results Financial incentives would have made a difference in the donation decision for 54% of nondonors (vs. 46% of donors, P = 0.02), and a higher percentage of nondonors would themselves become donors if financial incentives were available (P = 0.03). Donors had significantly more favorable attitudes toward donor authorization (P < 0.0001) and presumed consent (P < 0.0001) policies. Overall, 54% of participants thought that family permission for donation was unnecessary when the deceased documented their donation intention, and 24% favored a presumed consent law with an opting out provision. Conclusions Of the three initiatives, donor authorization is likely supported by more donor and nondonor families than either financial incentives or presumed consent. Public education efforts should aim to better inform the public regarding existing and proposed donor authorization legislation and its benefits for registered organ donors and their families. PMID:16699449

Rodrigue, James R.; Cornell, Danielle L.; Howard, Richard J.

2008-01-01

142

Introduction There are many varieties of dog collars available to dog  

E-print Network

1 Introduction There are many varieties of dog collars available to dog owners today. The primary purpose of a collar is to provide an effective way for the owner to control his/her dog. In addition collars are appropriate for wear at all times, while others are specifically for walking the dog

143

Assisting Handlers Following Attacks on Dog Guides: Implications for Dog Guide Teams  

ERIC Educational Resources Information Center

Attacks by dogs on dog guides are traumatic for dog guide teams. One variable that affects a team's recovery is how handlers cope with emotional responses to the attack. This article presents a three-stage model for assisting handlers that is useful for handlers and dog guide instructors.

Godley, Cheryl A.; Gillard, Marc A.

2011-01-01

144

Infarcts in the anterior choroidal artery territory. Anatomical distribution, clinical syndromes, presumed pathogenesis and early outcome.  

PubMed

From a prospective registry of all consecutive patients with a supratentorial ischaemic stroke, those with a compatible CT lesion were selected to study topographical relationship, clinical syndrome, vascular risk factors, signs of large-vessel disease or cardiogenic embolism, and mortality in cases with an infarct in the anterior choroidal artery (AChA) territory in comparison with other infarct subtypes. First we identified the area supplied by the AChA: in accordance with the consensus in the literature the posterior two-thirds of the posterior leg of the internal capsule was considered as certain AChA territory. After reviewing CT scans, all presumed small deep AChA territory infarcts were displayed in a schematic composite picture of super-imposed areas of infarction in different shades of grey. Infarcts that were located largely outside the generally included territory were presumed to belong to a different vascular territory. Thus, 77 small deep infarcts were considered to be located within, and 83 outside the AChA territory. Twenty-nine AChA infarcts extended from the internal capsule upwards into the posterior paraventricular corona radiata region. Furthermore, the composite representation of 26 infarcts restricted to the posterior part of the paraventricular corona radiata region showed almost complete overlap with the area occupied by AChA infarcts that extended upwards. We therefore concluded that the posterior paraventricular area is most likely supplied by the AChA. The frequency of a clinical lacunar or a cortical syndrome did not differ between small deep AChA and remaining small deep infarcts. Comparison of vascular risk factors by way of multivariate regression analysis only showed that a significant carotid stenosis was more frequent (adjusted odds ratio 8.87; 95% confidence interval 1.44-54.50), and a cardioembolic source was less frequent (odds ratio 0.24; 95% confidence interval 0.07-0.92) in AChA infarcts than in the other small deep infarcts. Carotid stenosis and cardiac embolism were less frequent in AChA infarcts than in superficial infarcts (odds ratio 0.33, 0.23, respectively; 95% confidence interval 0.15-0.74, 0.09-0.52, respectively). One month and one year mortality were lower in small deep infarcts compared with superficial infarcts, but most favourable in the AChA group. However, this was probably related to younger age in the AChA patients. Larger AChA infarcts were infrequent in our series; six of such cases did not differ in any respect from superficial infarcts. We conclude that the posterior paraventricular corona radiata region is most likely supplied by the AChA, and that AChA infarcts do not constitute a separate brain infarct entity.(ABSTRACT TRUNCATED AT 400 WORDS) PMID:7922468

Hupperts, R M; Lodder, J; Heuts-van Raak, E P; Kessels, F

1994-08-01

145

Dog Feeding and By: Jennifer Cooper  

E-print Network

level, age of dog, and overall size of dog. Consult your veterinarian on the amounts to be fed Pedigree dropper Tourniquet Tweezers Avoid Obesity Avoid table scraps Feed veterinarian recommended amounts

Selmic, Sandra

146

49 CFR 236.718 - Chart, dog.  

Code of Federal Regulations, 2013 CFR

...Transportation 4 2013-10-01 2013-10-01 false Chart, dog. 236.718 Section 236.718 Transportation Other...DEVICES, AND APPLIANCES Definitions § 236.718 Chart, dog. A diagrammatic representation of the mechanical locking...

2013-10-01

147

49 CFR 236.718 - Chart, dog.  

Code of Federal Regulations, 2011 CFR

...Transportation 4 2011-10-01 2011-10-01 false Chart, dog. 236.718 Section 236.718 Transportation Other...DEVICES, AND APPLIANCES Definitions § 236.718 Chart, dog. A diagrammatic representation of the mechanical locking...

2011-10-01

148

49 CFR 236.718 - Chart, dog.  

Code of Federal Regulations, 2014 CFR

...Transportation 4 2014-10-01 2014-10-01 false Chart, dog. 236.718 Section 236.718 Transportation Other...DEVICES, AND APPLIANCES Definitions § 236.718 Chart, dog. A diagrammatic representation of the mechanical locking...

2014-10-01

149

49 CFR 236.718 - Chart, dog.  

Code of Federal Regulations, 2012 CFR

...Transportation 4 2012-10-01 2012-10-01 false Chart, dog. 236.718 Section 236.718 Transportation Other...DEVICES, AND APPLIANCES Definitions § 236.718 Chart, dog. A diagrammatic representation of the mechanical locking...

2012-10-01

150

Stray Dogs: Danijel Zezelj  

NSDL National Science Digital Library

The website of the Isabella Stewart Gardner Museum in Boston has a digitized version of its contemporary exhibition, from several years ago, that featured the drawings of graphic novelist Danijel Zezelj. The digital exhibition provides a written excerpt of an informative "Interview" with the artist by the curator of the exhibit, and visitors can find the interview under the "Artist Biography" link. To view the exhibition, visitors should click on the "Enter the Exhibition" link, which contains the drawings from the graphic novel "Stray Dogs", but without the accompanying text found in the novel. Each page is an artwork in itself, and contains several seemingly separate drawings per page. The beautiful drawings sometimes resemble paintings or lithographs, with their large swaths of ink. The "Exhibition Details" link is an interesting peek inside the business of lending out a museum exhibit, and visitors will find the criteria for borrowing the work including: the space requirements of the exhibition, the required color of the walls (Autumn Purple by Benjamin Moore), the cost to borrow it from the museum, the cost of multimedia performances related to the exhibit, and the cost of an artist talk.

151

Effect of nitroglycerin on myocardial collateral conductance in awake dogs  

SciTech Connect

Conductance of the coronary collateral circulation during the course of two abrupt circumflex coronary occlusions was measured in awake dogs {approximately} 2 wk after collateral vessels were stimulated to develop. The pressure gradient from the central aorta to the distal circumflex coronary artery was measured, and myocardial blood flow was determined by 9-{mu}m radioactive microspheres at 30 s and 4 min after coronary occlusions. Collateral conductance was calculated as mean collateral blood flow divided by the mean aorta-coronary pressure gradient. Before nitroglycerin, collateral conductance increased in all eight dogs from 30 s to 4 min. After nitroglycerin administration, the conductance at 30 s increased from the prenitroglycerin control value to 0.014 {+-} 0.012 ml{center dot}min{sup {minus}1}{center dot}g{sup {minus}1}{center dot}mmHg{sup {minus}1}. The mean change in conductance from 30 s to 4 min postnitroglycerin was significantly less than during prenitroglycerin. These data indicate that an increase in conductance during coronary occlusion occurs even in the immature collateral circulation. This effect presumably takes place in the arterial smooth muscle at the origin of the collateral vasculature.

Brazzamano, S.; Rembert, J.C.; Greenfield, J.C. Jr. (Duke Medical Center, Durham, NC (USA))

1988-04-01

152

Lymphocytic ganglioneuritis secondary to intervertebral disc extrusion in a dog.  

PubMed

This study presents a case of lymphocytic ganglioneuritis in a dog secondary to intervertebral disc extrusion that mimicked a peripheral nerve sheath tumour on magnetic resonance imaging. A four-year-old spayed female dachshund with lumbar pain was imaged via magnetic resonance. A?tubular, space-occupying, contrast-enhancing lesion was noted in the right intervertebral foramen at L6 to L7. This was presumed to represent focal enlargement of the right sixth lumbar spinal nerve. A?right-sided haemilaminectomy was performed at L6 to L7 and material that grossly resembled extruded nucleus pulposus was removed. The right L6 dorsal root ganglion, dorsal nerve root and proximal spinal nerve were severely enlarged and a partial thickness biopsy was collected from the dorsal root ganglion. Results of histopathological examination of the submitted tissue samples were consistent with extruded disc material and lymphocytic ganglioneuritis. To the author's knowledge, this is the first published report of lymphocytic ganglioneuritis secondary to intervertebral disc disease in a dog. PMID:24779364

Mouradian-Darby, A E; Young, B D; Griffin, J F; Mansell, J; Levine, J M

2014-09-01

153

Noninvasive radioisotopic technique for detection of platelet deposition in mitral valve prostheses and quantitation of visceral microembolism in dogs  

SciTech Connect

A noninvasive technique has been developed in the dog model for imaging, with a gamma camera, the platelet deposition on Bjoerk-Shiley mitral valve prostheses early postoperatively. At 25 hours after implantation of the prosthesis and 24 hours after intravenous administration of 400 to 500 microCi of platelets labeled with indium-111, the platelet deposition in the sewing ring and perivalvular cardiac tissue can be clearly delineated in a scintiphotograph. An in vitro technique was also developed for quantitation of visceral microemboli in brain, lungs, kidneys, and other tissues. Biodistribution of the labeled platelets was quantitated, and the tissue/blood radioactivity ratio was determined in 22 dogs in four groups: unoperated normal dogs, sham-operated dogs, prosthesis-implanted dogs, and prosthesis-implanted dogs treated with dipyridamole before and aspirin and dipyridamole immediately after operation. Fifteen to 20% of total platelets were consumed as a consequence of the surgical procedure. On quantitation, we found that platelet deposition on the components of the prostheses was significantly reduced in prosthesis-implanted animals treated with dipyridamole and aspirin when compared with prosthesis-implanted, untreated dogs. All prosthesis-implanted animals considered together had a twofold to fourfold increase in tissue/blood radioactivity ratio in comparison with unoperated and sham-operated animals, an indication that the viscera work as filters and trap platelet microemboli that are presumably produced in the region of the mitral valve prostheses. In the dog model, indium-111-labeled platelets thus provide a sensitive marker for noninvasive imaging of platelet deposition on mechanical mitral valve prostheses, in vitro evaluation of platelet microembolism in viscera, in vitro quantitation of surgical consumption of platelets, and evaluation of platelet-inhibitor drugs.

Dewanjee, M.K.; Fuster, V.; Rao, S.A.; Forshaw, P.L.; Kaye, M.P.

1983-05-01

154

Scavenging by mammalian carnivores on prairie dog colonies: implications for the spread of plague.  

PubMed

Plague causes mass mortality of prairie dogs (Cynomys ludovicianus) in shortgrass steppe. Although the pathogen, the bacterium Yersinia pestis, is spread within colonies by flea bites or contact between infected hosts, it is unclear how Y. pestis is transported over long distances between isolated colonies. One possibility is that wideranging, plague-resistant mammalian carnivores pick up fleas when scavenging prairie dog carcasses. Using guinea pigs as surrogates for prairie dogs, we compared how quickly scavengers discovered carcasses on active prairie dog colonies, on colonies recently extirpated by plague, and in grasslands without prairie dogs. In June-July 2007, we monitored the fates of 20 guinea pig carcasses for 4 consecutive days on each site type. Ten carcasses were placed in wire exclosures that restricted access only to arthropods and small rodents; the other 10 were exposed to all scavengers. Scavengers were identified by tracks, evidence of consumption, and/or remote cameras. Carnivores discovered carcasses more quickly on active and plague colonies (mean +/- 95% confidence interval [CI]: 1.6 +/- 0.7, 1.4 +/- 1.4 days, respectively) than on grasslands (3.1 +/- 0.7 days). By the end of the trials, all (100%) exposed carcasses were removed from active colonies, whereas 60% were removed from plague colonies and 30% were removed from grasslands. Rates of carcass discovery and removal on active colonies were significantly greater than in grasslands, which mirrored differences in carnivore activity recorded during earlier scat surveys. A small fraction (30%-40%) of carcasses in exclosures were eaten by rodents, but only on active and plague colonies, suggesting that small rodents, presumably grasshopper mice (Onychomys leucogaster), may also consume carcasses and pick up fleas if carcasses are not removed by carnivores first. These results, combined with observations that fleas remain alive on prairie dogs at least 1 day following their death, suggest that carnivores may encounter infectious fleas while scavenging, and they could transport them over long distances. PMID:18945188

Boone, Amanda; Kraft, John P; Stapp, Paul

2009-04-01

155

Fecal Microbiome in Dogs with Acute Diarrhea  

E-print Network

with acute diarrhea (AD; both NHD and AHD groups combined) compared to healthy dogs (p=0.0020). Sequences belonging to Bacteroidetes were significantly decreased in dogs with AD compared to healthy dogs (p=0.0280). Sequences belonging to the genus...

Guard, Blake Crosby

2013-11-07

156

Old Tricks, New Dogs: Ethology and Interactive  

E-print Network

1 Old Tricks, New Dogs: Ethology and Interactive Creatures Bruce Mitchell Blumberg Bachelor of Arts:.................................................................................................................................................................... #12;2 Old Tricks, New Dogs: Ethology and Interactive Creatures #12;3 Old Tricks, New Dogs: Ethology creatures by com- bining key ideas from Ethology and Classical Animation. We have developed a toolkit based

157

NEONATAL NEOSPORA CANINUM INFECTIONS IN DOGS  

Technology Transfer Automated Retrieval System (TEKTRAN)

Neosporosis was diagnosed ante-mortem in a litter of neonatally-infected dogs. Three pups developed weakness of limbs 7-9 weeks after birth. One of the dogs developed megaesophagus. Treatment with clindamycin improved clinical signs but did not eradicate the parasite. All 3 dogs were euthanized and ...

158

Dogs as pets, visitors, therapists and assistants.  

PubMed

Dogs can play an integral role in the recovery of patients through companionship, animal-assisted therapy, and as assistance dogs. This article will define and differentiate these 3 categories and provide resources for home healthcare and hospice clinicians who may want to include dogs in the plan of care for select patients. PMID:25370974

Winkle, Melissa Y; Wilder, Anna; Jackson, Liberty Z

2014-01-01

159

NEW ENGLAND 4-H DOG CLINIC  

E-print Network

NEW ENGLAND 4-H DOG CLINIC Saturday, May 5, 2012 Tolland Agricultural Center, Route 30, Vernon CT Registration ­ 8am-8:45am Workshops begin at 9am Event ends at 4:00pm #12;Enrollment in the New England 4-H Dog Clinic is limited to 30 participants and their dogs. All youth ages referred to in this brochure are ages

Holsinger, Kent

160

Barking in family dogs: An ethological approach  

Microsoft Academic Search

Although it is one of the most conspicuous features of dog behaviour, barking has received little attention from ethologists or from an applied perspective. In this review, an ethological look is taken at the communicative aspect of dog barking. Emerging new research has indicated that in the repertoire of dog vocalisations barking has unique features in showing wide ranges of

Péter Pongrácz; Csaba Molnár; Ádám Miklósi

2010-01-01

161

Chronic mesenteric volvulus in a dog.  

PubMed

A chronic, partial mesenteric volvulus was found on laparotomy of an adult Bernese mountain dog with a 4-month history of intermittent vomiting, diarrhea, and weight loss. The dog had elevated cholestatic and hepatocellular leakage enzymes, increased bile acids, azotemia, isosthenuria, and a hypokalemic, hypochloremic, metabolic alkalosis. The dog recovered fully following reduction of the volvulus. PMID:20357947

Spevakow, Andrea B; Nibblett, Belle Marie D; Carr, Anthony P; Linn, Kathleen A

2010-01-01

162

49 CFR 236.743 - Dog, swing.  

Code of Federal Regulations, 2012 CFR

...Transportation 4 2012-10-01 2012-10-01 false Dog, swing. 236.743 Section 236.743 Transportation...DEVICES, AND APPLIANCES Definitions § 236.743 Dog, swing. A locking dog mounted in such a manner that it is free to...

2012-10-01

163

50 CFR 216.82 - Dogs prohibited.  

Code of Federal Regulations, 2013 CFR

...2013-10-01 2013-10-01 false Dogs prohibited. 216.82 Section 216...Pribilof Islands Administration § 216.82 Dogs prohibited. In order to prevent molestation of fur seal herds, the landing of any dogs at Pribilof Islands is prohibited....

2013-10-01

164

49 CFR 236.743 - Dog, swing.  

Code of Federal Regulations, 2011 CFR

...Transportation 4 2011-10-01 2011-10-01 false Dog, swing. 236.743 Section 236.743 Transportation...DEVICES, AND APPLIANCES Definitions § 236.743 Dog, swing. A locking dog mounted in such a manner that it is free to...

2011-10-01

165

49 CFR 236.743 - Dog, swing.  

Code of Federal Regulations, 2010 CFR

...Transportation 4 2010-10-01 2010-10-01 false Dog, swing. 236.743 Section 236.743 Transportation...DEVICES, AND APPLIANCES Definitions § 236.743 Dog, swing. A locking dog mounted in such a manner that it is free to...

2010-10-01

166

50 CFR 216.82 - Dogs prohibited.  

Code of Federal Regulations, 2012 CFR

...2012-10-01 2012-10-01 false Dogs prohibited. 216.82 Section 216...Pribilof Islands Administration § 216.82 Dogs prohibited. In order to prevent molestation of fur seal herds, the landing of any dogs at Pribilof Islands is prohibited....

2012-10-01

167

50 CFR 216.82 - Dogs prohibited.  

Code of Federal Regulations, 2010 CFR

...2010-10-01 2010-10-01 false Dogs prohibited. 216.82 Section 216...Pribilof Islands Administration § 216.82 Dogs prohibited. In order to prevent molestation of fur seal herds, the landing of any dogs at Pribilof Islands is prohibited....

2010-10-01

168

49 CFR 236.743 - Dog, swing.  

Code of Federal Regulations, 2014 CFR

...Transportation 4 2014-10-01 2014-10-01 false Dog, swing. 236.743 Section 236.743 Transportation...DEVICES, AND APPLIANCES Definitions § 236.743 Dog, swing. A locking dog mounted in such a manner that it is free to...

2014-10-01

169

49 CFR 236.743 - Dog, swing.  

Code of Federal Regulations, 2013 CFR

...Transportation 4 2013-10-01 2013-10-01 false Dog, swing. 236.743 Section 236.743 Transportation...DEVICES, AND APPLIANCES Definitions § 236.743 Dog, swing. A locking dog mounted in such a manner that it is free to...

2013-10-01

170

50 CFR 216.82 - Dogs prohibited.  

Code of Federal Regulations, 2014 CFR

...2014-10-01 2014-10-01 false Dogs prohibited. 216.82 Section 216...Pribilof Islands Administration § 216.82 Dogs prohibited. In order to prevent molestation of fur seal herds, the landing of any dogs at Pribilof Islands is prohibited....

2014-10-01

171

50 CFR 216.82 - Dogs prohibited.  

Code of Federal Regulations, 2011 CFR

...2011-10-01 2011-10-01 false Dogs prohibited. 216.82 Section 216...Pribilof Islands Administration § 216.82 Dogs prohibited. In order to prevent molestation of fur seal herds, the landing of any dogs at Pribilof Islands is prohibited....

2011-10-01

172

Dipylidium (Dog and Cat Flea Tapeworm) FAQs  

MedlinePLUS

... the most common kind of tapeworm dogs and cats get? The most common tapeworm of dogs and cats in the United States is called Dipylidium caninum . ... infected with a tapeworm larvae. A dog or cat may swallow a flea while self-grooming. Once ...

173

Evaluating the effect of intraoperative peritoneal lavage on bacterial culture in dogs with suspected septic peritonitis  

PubMed Central

This pilot study describes the effect of intraoperative peritoneal lavage (IOPL) on bacterial counts and outcome in clinical cases of septic peritonitis. Intraoperative samples were cultured before and after IOPL. Thirty-three dogs with presumed septic peritonitis on the basis of cytology were managed surgically during the study period. Positive pre-lavage bacterial cultures were found in 14 cases, 13 of which were a result of intestinal leakage. The post-lavage cultures showed fewer isolates in 9 cases and in 1 case became negative. The number of dogs with a decrease in the concentration of bacteria cultured from pre-lavage to post-lavage samples was not statistically significant. There was no significant effect of the change in pre- to post-lavage culture, single versus multiple types of bacteria, selection of an appropriate empiric antimicrobial on survival or the need for subsequent surgery. PMID:23450861

Swayne, Seanna L.; Brisson, Brigitte; Weese, J. Scott; Sears, William

2012-01-01

174

Assessment of coyote-wolf-dog admixture using ancestry-informative diagnostic SNPs  

PubMed Central

The evolutionary importance of hybridization as a source of new adaptive genetic variation is rapidly gaining recognition. Hybridization between coyotes and wolves may have introduced adaptive alleles into the coyote gene pool that facilitated an expansion in their geographic range and dietary niche. Furthermore, hybridization between coyotes and domestic dogs may facilitate adaptation to human-dominated environments. We genotyped 63 ancestry-informative single nucleotide polymorphisms in 427 canids in order to examine the prevalence, spatial distribution, and ecology of admixture in eastern coyotes. Using multivariate methods and Bayesian clustering analyses, we estimated the relative contributions of western coyotes, western and eastern wolves, and domestic dogs to the admixed ancestry of Ohio and eastern coyotes. We found that eastern coyotes form an extensive hybrid swarm, with all our samples having varying levels of admixture. Ohio coyotes, previously thought to be free of admixture, are also highly admixed with wolves and dogs. Coyotes in areas of high deer density are genetically more wolf-like, suggesting that natural selection for wolf-like traits may result in local adaptation at a fine geographic scale. Our results, in light of other previously published studies of admixture in Canis, reveal a pattern of sex-biased hybridization, presumably generated by male wolves and dogs mating with female coyotes. This study is the most comprehensive genetic survey of admixture in eastern coyotes and demonstrates that the frequency and scope of hybridization can be quantified with relatively few ancestry-informative markers. PMID:24148003

Monzón, J.; Kays, R.; Dykhuizen, D. E.

2014-01-01

175

Prevalence of Giardia and Cryptosporidium species in dog park attending dogs compared to non-dog park attending dogs in one region of Colorado.  

PubMed

Dog parks are very popular in urban areas, but there are no current studies attempting to correlate visits to dog parks and risk of colonization by enteric parasites. The purpose of this study was to determine whether dog park visitation is associated with an increased prevalence of enteric parasites or an increase in prevalence of gastrointestinal signs in dogs in northern Colorado. Feces from dogs owned by veterinary students or Veterinary Teaching Hospital staff members were submitted with a completed survey form detailing dog park attendance rates, fecal character scores, and other clinical information. Feces were examined microscopically for parasites after sugar centrifugation, for Giardia spp. cysts and Cryptosporidium spp. oocysts by a commercially available immunofluorescence assay (FA) and the FA positive samples were genotyped after PCR amplification. The Giardia assemblages were determined using the glutamate dehydrogenase (GDH) ?-giardin and triose phosphate isomerase (TPI) genes and the Cryptosporidium species were determined using the heat shock protein-70 gene. A total of 129 fecal samples were assayed; 66 were from dog park attending dogs and 63 were from non-dog park-attending dogs. The overall parasite prevalence rate was 7.0% (9 of 129 samples). Dog park attending dogs were more likely to be positive for Giardia or Cryptosporidium than non-dog park-attending dogs (p=0.0279), but there was no association of gastrointestinal signs with dog park attendance or with fecal flotation or FA results. The five Giardia isolates were assemblage C and/or D and the one Cryptosporidium isolate was Ctenocephalides canis. PMID:21890275

Wang, Andrea; Ruch-Gallie, Rebecca; Scorza, Valeria; Lin, Philip; Lappin, Michael R

2012-03-23

176

Does getting a dog increase recreational walking?  

PubMed Central

Background This study examines changes in socio-demographic, environmental and intrapersonal factors associated with dog acquisition in non-dog owners at baseline to 12-months follow-up and the effect of dog acquisition on minutes per week of recreational walking. Methods RESIDE study participants completed self-administered questionnaires (baseline and 12-months follow-up) measuring physical activity, dog ownership, dog walking behavior as well as environmental, intrapersonal and socio-demographic factors. Analysis was restricted to 'Continuing non-owners' (i.e., non-owners at both baseline and follow-up; n = 681) and 'New dog owners' (i.e., non-owners who acquired a dog by follow-up; n = 92). Results Overall, 12% of baseline non-owners had acquired a dog at follow-up. Dog acquisition was associated with working and having children at home. Those who changed from single to couple marital status were also more likely to acquire a dog. The increase in minutes of walking for recreation within the neighborhood from baseline to follow-up was 48 minutes/week for new dog owners compared with 12 minutes/week for continuing non-owners (p < 0.05). After adjusting for baseline variables the effect of dog acquisition on the increase in minutes of recreational walking within the neighborhood was 31 minutes (95% CI: 7.39, 54.22; p < 0.01). However, this reduced to 22 minutes (95% CI: -1.53, 45.42; p > 0.05) after further adjustment for change in baseline to follow-up variables. Increase in intention to walk was the main factor contributing to attenuation of the effect of dog acquisition on recreational walking. Conclusion This study used a large representative sample of non-owners to examine the relationship between dog acquisition and recreational walking and provides evidence to suggest that dog acquisition leads to an increase in walking. The most likely mechanism through which dog acquisition facilitates increased physical activity is through behavioral intention via the dog's positive effect on owner's cognitive beliefs about walking, and through the provision of motivation and social support for walking. The results suggest that behavioral intention mediates the relationship between dog acquisition and walking and that dogs may have a significant role in the maintenance of owner walking behavior. PMID:18366804

Cutt, Hayley E; Knuiman, Matthew W; Giles-Corti, Billie

2008-01-01

177

Hepatosplenic lymphoma in a dog  

Microsoft Academic Search

We describe a case of a dog with hepatosplenic lymphoma, a disease characterized by infiltration of the liver, spleen, and bone marrow with gammadelta T cells, absence of peripheral lymphadenopathy, and an aggressive clinical course. Physical examination findings, hematologic and biochemical abnormalities, and clinical course of the disease in this patient were similar to those in humans. Immunophenotyping of liver

Michael M Fry; W. Vernau; C Bromel; P A Pesavento; P. F. Moore

2003-01-01

178

A safety study of a novel photosensitizer, sinoporphyrin sodium, for photodynamic therapy in Beagle dogs.  

PubMed

Sinoporphyrin sodium (DVDMS) is a novel hematoporphyrin-like photosensitizer developed for photodynamic therapy (PDT), an effective therapeutic modality for tumor treatment; however, the safety of photosensitizer-based PDT is always of great concern. The purpose of the current study was to investigate the potential repeated-dose toxicity and describe the toxicokinetic process of DVDMS-based PDT in Beagle dogs. The dogs were randomly allocated to six groups, and then were administrated a DVDMS preparation intravenously at dose levels of 0, 1, 3, 9, 1 and 9 mg per kg body weight, respectively; then, the latter two groups were illuminated 24 h later with a 630 nm laser for 10 min, once every seven days for 5 weeks. During the study period, clinical signs, mortality, body weight, food consumption, body temperature, ophthalmoscopy, hematology, serum biochemistry, urinalysis, electrocardiograms, toxicokinetics, organ weights, gross anatomy and histopathology were examined. After the administration, no deaths were observed; however, the dogs that received PDT showed skin swelling and ulceration, indicating that DVDMS-PDT induced a phototoxic effect. DVDMS led to an increase in blood coagulation in dogs in the 9 mg kg(-1) group and in the two PDT groups on Day 35, whereas it induced a decrease in dogs in the 3 mg kg(-1) group and in the two PDT groups on Day 49. The toxicokinetic study showed that the systematic exposure of DVDMS in dogs occurred in a dose-dependent manner, and DVDMS did not accumulate in blood plasma. The DVDMS-based PDT group showed no obvious treatment-related pathological changes; however, slight or mild brown-and-yellow pigmentation of DVDMS (or its metabolite) was observed to deposit in the liver, spleen, local lymph nodes and marrow of dogs in the mid- and high-dose groups, as well as the high-dose PDT group. In females, the absolute and relative spleen weights increased in dogs in the 9 mg kg(-1) DVDMS groups with and without PDT during the treatment and recovery period, respectively. The target organs are presumed to be the liver and immune organs (spleen, bone marrow and lymph nodes), while all of the responses were slight. Based on the results above, the no-observed-adverse-effect level (NOAEL) was considered to be 1 mg kg(-1), and DVDMS-PDT appeared to be a safe and promising anti-tumor therapy in the clinic. PMID:25671327

Lin, Ni; Li, Chao; Wang, Zhonghua; Zhang, Jingxuan; Ye, Xiangfeng; Gao, Wenjing; Wang, Aiping; Jin, Hongtao; Wei, Jinfeng

2015-04-01

179

[Lens luxation in dogs: a retrospective study of 134 dogs (2000-2011)].  

PubMed

This retrospective study evaluated cases of lens luxation in dogs that were documented at the University of Zurich Veterinary Teaching Hospital between 2000 and 2011. A total 134 dogs were included in the study. This population of dogs with lens luxation represents 0.41 % of all dogs presented to the Zurich Veterinary Teaching Hospital (32'523) and 3.02 % of all dogs presented to the ophthalmology service during the same time period. The 134 dogs represented over 40 different breeds, including mixed breeds. 63 of the dogs were male, 71 were female. The 134 dogs were divided in primary lens luxation (86 of the 134 dogs, 64 %) and secondary lens luxation (48 dogs, 36 %). The most frequent causes for secondary lens luxation were glaucoma (58 %), cataract (19 %) and trauma (17 %). This study shows the predisposition for primary lens luxations in terrier breeds, Chinese Crested dogs, Pinscher and Spitz. In contrast, Siberian Huskies, Basset Hounds, Bearded Collies, Cairn Terriers, mixed breed dogs, Bolonka Zwetna, Boston Terriers, Borzoi, Doberman, Eurasian, Leonberg, Luzerner Niederlaufhund and Weimaraner suffered significantly more often from secondary lens luxation. There was no sex predilection for primary or secondary lens luxation. Dogs with primary lens luxation were on average 7.39 ± 3.02 years old, which is significantly younger than the dogs with secondary lens luxation (9.12 ± 3.38 years). Dogs with primary lens luxation showed a significantly higher rate of a bilateral development than those with secondary lens luxation (85.5 % of the dogs with primary lens luxation and only 14.5 % of the dogs with secondary lens luxation showed it in both their eyes). PMID:24568806

Betschart; Hässig; Spiess

2014-03-01

180

WASHINGTON STATE 4-H DOG OBEDIENCE PROGRAM LONG SIT / LONG DOWN GROUP EXAMINATION CHART  

E-print Network

WASHINGTON STATE 4-H DOG OBEDIENCE PROGRAM LONG SIT / LONG DOWN GROUP EXAMINATION CHART SHOW LONG DOWN Long Sit Sit your dog Leave your dog Back to your dog Exercise finished Long Down Down your dog Leave your dog Back to your dog Exercise finished A Did not remain in place B Went to another dog

New Hampshire, University of

181

Going to the Dogs: The Dog and I, LLC  

ERIC Educational Resources Information Center

How do you go from being a successful mechanical engineer or the manager of an optical store to giving up the security of those positions and caring for man's best friend? Just ask the mother and daughter team of Diane Holstein and Lisa Ferrerio, co-owners of The Dog and I. Everyone has the dream of doing a job they love, but not everyone can make…

Carlson, Priscilla

2008-01-01

182

Prevalence of staphylococcal enterotoxins in Staphylococcus pseudintermedius isolates from dogs with pyoderma and healthy dogs.  

PubMed

To investigate the role of staphylococcal enterotoxins (SEs) produced by Staphylococcus pseudintermedius in the pathogenesis of pyoderma, isolates from dogs with pyoderma and healthy dogs were analyzed. According to reverse passive latex agglutination, 14/184 isolates (7.6%) from dogs with pyoderma and 9/87 (10.3%) from healthy dogs produced SEs (SEA, SEC or SED). According to multiplex PCR, 99 isolates (53.7%) from dogs with pyoderma and 97 (90.8%) from healthy dogs possessed one or more se genes. There was no significant difference regarding ses between dogs with pyoderma and healthy dogs. Therefore, SEs may not be a direct virulence factor in pyoderma. PMID:23659343

Tanabe, Taishi; Toyoguchi, Midori; Hirano, Fumitaka; Chiba, Mei; Onuma, Kenta; Sato, Hisaaki

2013-09-01

183

Prostacyclin inhibits gastric emptying and small-intestinal transit in rats and dogs  

SciTech Connect

Prostacyclin (PGI2) antagonizes 16,16-dimethyl prostaglandin E2-induced diarrhea in rats, presumably by inhibiting the fluid accumulation of ''enteropooling'' in the small intestine. The effect of PGI2 on gastric emptying, small intestinal transit, and colonic transit was examined in rats and dogs to determine if interference with propulsion might also contribute to the antidiarrheal properties of this compound. Rats implanted with chronic duodenal cannulas were given subcutaneous PGI2 (0.1-1000 microgram/kg) followed 10 min later by intragastric /sup 2/Cr and a visually detectable duodenal transit marker. Forty-five minutes later, the animals were killed. Subcutaneous PGI2 inhibited gastric emptying maximally at 10 micrograms/kg. Small-intestinal transit was significantly decreased at 50 micrograms/kg and almost completely suppressed at 1.0 mg/kg. Subcutaneous naloxone (0.5 mg/kg) given 10 min before and 20 min after subcutaneous PGI2 administration did not block PGI2's effects. Intravenous or oral PGI2, had none of these effects. Small intestinal transit was only decreased by PGI2 infusion, suggesting that this parameter was more sensitive to a sustained blood level than gastric emptying. Hourly injections of subcutaneous PGI2 (0.5 mg/kg) had no effect on rat colonic transit measured over a 3-h period after deposition of the transit marker through a colonic cannula in a manner similar to that described for small-intestinal transit above. Small-intestinal transit was also measured in dogs given a barium suspension through a chronic duodenal cannula. In vehicle-treated dogs, barium reached the cecal area in an average of 2.8 h after instillation. In PGI2-treated dogs, barium never reached the cecum in the 5-h examination period. Thus, PGI2 inhibits gastric emptying in rat and small-intestinal transit in rat and dog but has no effect on rat colonic transit.

Ruwart, M.J.; Rush, B.D.

1984-08-01

184

Clinical and mycological analysis of dog’s oral cavity  

PubMed Central

The oral microbiota of humans and animals is made up of a wide variety of yeasts and bacteria, but microbiota of dogs is not totally described. Although such identification is an important step to establish the etiopathogenesis and adequate therapy for the periodontal disease The aim of this study was to evaluate and correlate oral alterations with the presence of yeasts in oral cavity of female dogs. After clinical evaluation samples from healthy and from dogs with oral diseases were obtained from three different oral sites by swabs, curettes, millimeter periodontal probes and HA membrane tip in cellulose ester. Yeast identification was performed through macroscopic and microscopic colony features and biochemical tests. Dental calculus was the most prevalent occurrence in the oral cavity of 59 females. However, the isolation of yeasts was significantly higher (p < 0.05) in animals suffering from halitosis. Eleven yeast species were identified, namely: Malassezia pachydermatis, Rhodotorula spp., Candida albicans, C. catenulata, C. famata, C. guilliermondii, C. parapsilosis, C. intermedia, Trichosporon asahii, T. mucoides and Cryptococcus albidus. It could be concluded that the yeasts are part of the microbiota from the different sites of the oral cavity of the female canines studied without causing any significant alterations except halitosis. PMID:24159296

Santin, Rosema; Mattei, Antonella Souza; Waller, Stefanie Bressan; Madrid, Isabel Martins; Cleff, Marlete Brum; Xavier, Melissa Orzechowski; de Oliveira Nobre, Márcia; Nascente, Patrícia da Silva; de Mello, Joăo Roberto Braga; Meireles, Mário Carlos Araújo

2013-01-01

185

Purification and characterization of liver catalase in acatalasemic beagle dog: comparison with normal dog liver catalase  

Microsoft Academic Search

Catalase from acatalasemic dog liver was purified to homogeneity and its properties were compared with those of normal dog liver catalase. The purified acatalasemic and normal dog liver catalases were found to have the same molecular weight (230,000 Da) and isoelectric point (pI: 6.0–6.2) and both enzymes contained four hematins per molecule. The catalytic activity of catalase from acatalasemic dog

Kouichi Nakamura; Misa Watanabe; Yukio Sasaki; Toshihiko Ikeda

2000-01-01

186

4-H Dog Fitting and Show Score Sheet Date _______________________ Class _________________  

E-print Network

4-H Dog Fitting and Show Score Sheet Date _______________________ Class _________________ Breed ______________________ Armband# ____________ Possible Points Points Earned Dog Condition and Appearance ____ Brushed without matting ____ Clean ears ____ Nails trimmed ____ Dog in good condition, not underweight 10 Handler

New Hampshire, University of

187

Spirocercosis-associated pyothorax in dogs.  

PubMed

The records of five dogs diagnosed with spirocercosis-associated pyothorax were retrospectively reviewed. On admission, the most common clinical findings were weakness, anorexia, depression, dyspnoea and fever. All dogs had typical oesophageal Spirocerca lupi granulomas. Contrast thoracic radiography revealed contrast material leakage from the oesophagus into the pleural cavity in two dogs only. All dogs were medically treated with broad-spectrum antibiotics, repeated chest tube drainage and thoracic lavage, and four of the dogs were treated with doramectin. One dog was euthanased due to a concurrent non-related disease at the owners request while the remaining four survived. S. lupi infection should be included in the differential diagnoses of canine pyothorax in endemic areas. Conservative medical management of pyothorax with antihelmintic medication was shown to be effective in the treatment of S. lupi-associated pyothorax. PMID:16246607

Klainbart, Sigal; Mazaki-Tovi, Michal; Auerbach, Neomi; Aizenberg, Itzhak; Bruchim, Yaron; Dank, Gillian; Lavy, Eran; Aroch, Itamar; Harrus, Shimon

2007-01-01

188

CANINE: a robotic mine dog  

NASA Astrophysics Data System (ADS)

Neya Systems, LLC competed in the CANINE program sponsored by the U.S. Army Tank Automotive Research Development and Engineering Center (TARDEC) which culminated in a competition held at Fort Benning as part of the 2012 Robotics Rodeo. As part of this program, we developed a robot with the capability to learn and recognize the appearance of target objects, conduct an area search amid distractor objects and obstacles, and relocate the target object in the same way that Mine dogs and Sentry dogs are used within military contexts for exploration and threat detection. Neya teamed with the Robotics Institute at Carnegie Mellon University to develop vision-based solutions for probabilistic target learning and recognition. In addition, we used a Mission Planning and Management System (MPMS) to orchestrate complex search and retrieval tasks using a general set of modular autonomous services relating to robot mobility, perception and grasping.

Stancil, Brian A.; Hyams, Jeffrey; Shelley, Jordan; Babu, Kartik; Badino, Hernán.; Bansal, Aayush; Huber, Daniel; Batavia, Parag

2013-01-01

189

Comparative Social Cognition of Dogs 26 Comparative Social Cognition: From wolf and dog to humans  

E-print Network

to the understanding of socio-cognitive behavior in the dog, a more ethologically oriented approach is clearly needed, their natural socialization to humans, and the possibility of tracing evolutionary changes by comparing dogs'behavior to that of wolves, make dogs altogether unique for studying the evolution of complex social behavior. Here

Indiana University

190

Reproductive potential of Echinococcus multilocularis in experimentally infected foxes, dogs, raccoon dogs and cats  

Microsoft Academic Search

A total of 15 red foxes, 15 raccoon dogs, 15 domestic dogs and 15 domestic cats were each infected with 20,000 protoscolices of Echinococcus multilocularis. At 35, 63, and 90 days post inoculation (dpi), five animals from each group were necropsied and the worm burdens determined. The highest worm burdens in foxes (mean of 16,792) and raccoon dogs (mean of

C. M. O. Kapel; P. R. Torgerson; R. C. A. Thompson; P. Deplazes

2006-01-01

191

"What Are All These Dogs Doing at School?" Using Therapy Dogs to Promote Children's Reading Practice  

ERIC Educational Resources Information Center

This article discusses how registered therapy dogs can motivate and support children as they practice reading aloud in the company of the dog and with the support of the dog's handler. It also offers practical advice to educators, librarians, administrators, and community members seeking to implement such a program in their communities.

Jalongo, Mary Renck

2005-01-01

192

Acceptance of Dog Guides and Daily Stress Levels of Dog Guide Users and Nonusers  

ERIC Educational Resources Information Center

The degree of acceptance of dog guides at public facilities, which is required by law in Japan, was investigated, and evidence of rejection was found. Japanese people with visual impairments who used dog guides reported higher daily stress levels than did those who did not use dog guides. (Contains 3 tables and 1 figure.)

Matsunaka, Kumiko; Koda, Naoko

2008-01-01

193

Super-Athletes ... sled dogs  

NSDL National Science Digital Library

Thirty-second monthly installment of our "What A Year!" website project, introducing life science breakthroughs to middle and high school students and their teachers. It would be impossible for a human to complete a 1,000-mile race, even if it were done in chunks, with plenty of recovery time. Unlike humans, sled dogs are able to maintain a high level of exercise for over two weeks without experiencing fatigue. Why is that?

2009-11-02

194

The Shadow of the Dog  

NSDL National Science Digital Library

This resource uses an everyday example of walking a dog as a context where students can observe changes in shadows over the course of a day, and deduce that light travels and tends to maintain its direction of motion. The activity is from PUMAS - Practical Uses of Math and Science - a collection of brief examples created by scientists and engineers showing how math and science topics taught in K-12 classes have real world applications.

195

Clifford the Big Red Dog  

NSDL National Science Digital Library

PBS Kids has companion sites for their programs that offer a number of activities for young users. This one features everyone's favorite enormous, bright-red pooch, Clifford. At Clifford's site, visitors can play a matching game, read a story, print a cut-out dog house, and print out pages to color. The site also offers some Clifford video clips. THe site is compact, easy to navigate, and well suited for their target audience.

196

OBSERVATIONS ON TETANY IN DOGS  

PubMed Central

Accessory parathyroid tissue unassociated with the thyroid lobes is present in 5 to 6 per cent. of dogs. For the determination of the presence of accessory parathyroid tissue there are two tests: (1) the anatomical, often entailing serial sections of the neck and upper thoracic structures, and (2) the biological, consisting of the daily use of some calcium salt for two to three weeks. The latter is more easily carried out and more accurate. In the absence of all parathyroid tissue calcium salts will not save the animal's life, while in the presence of active parathyroid tissue calcium will save it. Many factors other than the amount of parathyroid tissue removed influence the onset of tetany, among which are age, pregnancy, lactation, rachitis, the administration of sulphur, and diet. Pregnancy and lactation tetany in dogs resembles in all essentials parathyroid tetany. Our observations are in harmony with those who hold that the thyroid and parathyroid are independent structures as regards their anatomy, physiology, and pathology. The removal of the parathyroids immediately lowers alimentary sugar tolerance, but rarely to the degree of constant glycosuria. In sharp contrast with thyroid substance in myxedema, the feeding of parathyroid substance fresh or dried by mouth is of no value in the parathyroid tetanies of dogs. Calcium salts have a striking palliative effect on parathyroid tetany and preventative action in tiding over otherwise fatal cases, but are in no sense curative. The mode of action is unknown. There is some evidence that calcium salts directly influence the parathyroid gland. PMID:19867751

Marine, David

1914-01-01

197

Mixed-Breed Dogs Increasing in Popularity  

NSDL National Science Digital Library

To the average person words such as cockapoo, yorkipoo, and dorgi may seem inappropriate for polite conversation, but in actuality they are the names of mixed-breed dogs. Previously, many of these mixed-breed dogs (formerly referred to as mutts), would have been of little interest. But in recent years more and more people have become entranced with having these animals as household pets. The labradoodle, for example, was originally bred in Australia in the 1970s, and was used as a guide dog for allergy sufferers. These dogs are not at all cheap however, as some of these labradoodles can cost up to $4000. Another interesting development is that the labradoodle may become eligible for American Kennel Club recognition if there are at least 300 of them in at least 20 states with three substantiated generations of labradoodle to labradoodle mixing. Some dog experts are also touting the merits of these new mixes, claiming that the are in fact healthier than purebreds. Other experts in the field remain skeptical, such as Allan Reznik, editor-in-chief of Dog Fancy and Dog World magazines, who opined thusly: "It's indicative of a society that loves labels. Having a dog that is part spaniel and part poodle isn't enough -- it has to be a cockapoo."The first link leads to a news story from CNN.com that documents this latest trend in designer dogs, along with a nice table that deciphers what the names of these mixed-breeds mean exactly. The second link leads to another story about these new hybrid dogs from the National Geographic website, authored by Bijal P. Trivedi. The third link will take visitors to the homepage of the American Kennel Club, where they may read about various purebred dogs, browse a calendar of related events, and learn about the upcoming national dog championship event sponsored by the Club that will take place in Long Beach, California. The fourth link leads to a page devoted to the Schnoodle (a cross between a poodle and a schnauzer) provided by the Dog Breeder Info Center website. The fifth link leads to a site created by Catherine N. Ball (an adjunct professor of linguistics at Georgetown University) that offers a list of the words for the sounds that dogs make in several dozen languages, including Croatian, Esperanto, and Bengali. The final link leads to a fun site that allows visitors to engage in a virtual dog simulation game where they can prepare their animals to compete in the show ring.

198

Dog Bite Risk: An Assessment of Child Temperament and Child-Dog Interactions  

PubMed Central

Annually approximately 400,000 American children receive treatment for dog bites. Young children are at greatest risk and are frequently bitten following behavior that provokes familiar dogs. This study investigated the effects of child temperament on children’s interaction with dogs. Eighty-eight children aged 3.5–6 years interacted with a live dog. Dog and child behaviors were assessed through observational coding. Four child temperament constructs—impulsivity, inhibitory control, approach and shyness—were assessed via the parent-report Children’s Behavioral Questionnaire. Less shy children took greater risks with the dog, even after controlling for child and dog characteristics. No other temperament traits were associated with risk-taking with the dog. Based on these results, children’s behavior with unfamiliar dogs may parallel behavior with other novel or uncertain situations. Implications for dog bite intervention programs include targeting at-risk children and merging child- and parent-oriented interventions with existing programs geared toward the physical environment and the dog. PMID:23066411

Davis, Aaron L.; Schwebel, David C.; Morrongiello, Barbara A.; Stewart, Julia; Bell, Melissa

2012-01-01

199

Physiological reactions to fear provocation in dogs  

Microsoft Academic Search

Fear is a common behavioral problem in dogs. In this paper, we studied the association between behavioral and physiological responses in two potentially fear-eliciting situations. The aim was to establish whether it is possible to separate dogs of the collie breed that are fearful of floors and gunshots from those that are not by studying changes in heart rate and

E Hydbring-Sandberg; L W von Walter; K Höglund; K Svartberg; L Swenson; B Forkman

2004-01-01

200

Checking a Prairie Dog for Fleas  

USGS Multimedia Gallery

National Park Service veterinarian Kevin Castle checks an anaesthetized prairie dog for fleas in Wind Cave National Park.  Over 30 organizations and agencies are testing a USGS-developed oral vaccine to prevent the spread of plague in prairie dogs. If successful, the sylvat...

201

Energy metabolism of Inuit sled dogs.  

PubMed

We explored how seasonal changes in temperature, exercise and food supply affected energy metabolism and heart rate of Inuit dogs in Greenland. Using open flow respirometry, doubly labeled water, and heart rate recording, we measured metabolic rates of the same dogs at two different locations: at one location the dogs were fed with high energy food throughout the year while at the other location they were fed with low energy food during summer. Our key questions were: is resting metabolic rate (RMR) increased during the winter season when dogs are working? Does feeding regime affect RMR during summer? What is the proportion of metabolic rate (MR) devoted to specific dynamic action (SDA), and what is the metabolic scope of working Inuit sled dogs? The Inuit dogs had an extremely wide thermoneutral zone extending down to -25 degrees C. Temperature changes between summer and winter did not affect RMR, thus summer fasting periods were defined as baseline RMR. Relative to this baseline, summer MR was upregulated in the group of dogs receiving low energy food, whereas heart rate was downregulated. However, during food digestion, both MR and HR were twice their respective baseline values. A continuously elevated MR was observed during winter. Because temperature effects were excluded and because there were also no effects of training, we attribute winter elevated MR to SDA because of the continuous food supply. Working MR during winter was 7.9 times the MR of resting dogs in winter, or 12.2 times baseline MR. PMID:20012661

Gerth, Nadine; Redman, Paula; Speakman, John; Jackson, Sue; Starck, J Matthias

2010-04-01

202

Suspected cycad (Cycas revoluta) intoxication in dogs.  

PubMed

Three dogs which ingested part of the stem of a Japanese cycad (Cycas revoluta) vomited repeatedly within hours after ingestion, showed marked depression, severely congested mucous membranes, increased thirst and profuse salivation. Subsequent hematological and blood chemical investigation revealed elevated serum concentrations of alanine transaminase, an initial mild lymphocytopenia, thrombocytopenia and a leucocytosis. The dogs recovered uneventfully. PMID:1770498

Botha, C J; Naudé, T W; Swan, G E; Ashton, M M; van der Wateren, J F

1991-12-01

203

Intradural spinal arachnoid cyst in a dog.  

PubMed Central

An 8-month-old, spayed female dog was presented with signs localizing a neurologic lesion between the 3rd thoracic and 3rd lumbar vertebrae. An arachnoid cyst was diagnosed by myelography, and a dorsal laminectomy with durotomy was performed. The dog continues to do well 1-1/2 year after surgery. Images Figure 1. PMID:12001342

Webb, A A

1999-01-01

204

Histoplasmosis in a dog from New Brunswick  

PubMed Central

A young dog was presented with a history of chronic diarrhea, anorexia, and weight loss. Histoplasma capsulatum was suspected, based on cytologic examination of lymph node aspirates and peritoneal fluid, and confirmed by fungal culture. To our knowledge, this is the first case of histoplasmosis diagnosed in a dog in Atlantic Canada. PMID:17824159

Tyre, Erica; Eisenbart, David; Foley, Peter; Burton, Shelley

2007-01-01

205

Ebola Virus Antibody Prevalence in Dogs  

E-print Network

observed that several dogs were highly exposed to Ebola virus by eating infected dead animals. To examine whether these animals became infected with Ebola virus, we sampled 439 dogs and screened them by Ebola virus–specific immunoglobulin (Ig) G assay, antigen detection, and viral polymerase chain

Human Risk; Loďs Allela; Olivier Bourry; Régis Pouillot; André Délicat; Brice Kumulungui; Pierre Rouquet; Jean-paul Gonzalez; Eric M. Leroy

206

Pavlov's Dog - Nobel Prize Educational Game  

NSDL National Science Digital Library

The Pavlov's Dog game and related reading are based on some of the scientific achievements of Ivan Pavlov, who was awarded the 1904 Nobel Prize in Physiology or Medicine. Even though the first image that comes to mind with Ivan Pavlov is his drooling dogs, he was awarded the Nobel Prize for his pioneering studies of how the digestive system works.

2009-01-01

207

Original article Lectin histochemistry of dog major  

E-print Network

Original article Lectin histochemistry of dog major and minor salivary glands Mahmut Sozmen Peter, there was only weak staining in serous acini of parotid glands. Other lectins bound, to differcnt degrees gland / dog / lectin histochemistry * Correspondencc and reprints Tel.: (44)117 928 9525; fax: (44) 1 17

Boyer, Edmond

208

Common causes of male dog infertility.  

PubMed

A complete breeding soundness evaluation is essential for assessment of the infertile male dog. Cryptorchidism, a sex-limited autosomal recessive trait, is more common as a unilateral condition. Azoospermia is an ejaculate consisting of seminal plasma but lacking sperm; repeated semen collections in the presence of an estrual bitch will rule out inadequate experience and lack of sexual stimulation. Both carnitine and alkaline phosphatase (AP) are produced in the epididymis; seminal plasma AP concentrations>5000 U/L indicate a normal ejaculate, whereas <5000 U/L is associated with incomplete ejaculation. Benign prostatic hypertrophy (BPH), the most common age-related condition in intact male dogs, is characterized by a sanguineous urethral discharge, hematuria, or hemospermia; diagnosis is based on prostatic enlargement and confirmed by a transabdominal biopsy. Although castration is recommended, valuable breeding dogs can be given finasteride. Prostatitis is more common in older dogs with BPH. Culture of the third fraction of the ejaculate or urine obtained by cystocentesis is indicated. Bacterial prostatitis is treated with antibiotics with high lipid solubility. Some dogs with bacterial prostatitis may develop prostatic abscesses (a medical and surgical emergency). Prostatic cysts are often asymptomatic. Approximately, 5-7% of dogs with prostatic disease have prostatic neoplasia, most commonly adenocarcinoma (it occurs in both intact and castrated dogs), which often metastasizes and has a very poor prognosis. Although a specific diagnosis can be made in many cases of male dog infertility, not all causes are amenable to treatment. PMID:17512045

Memon, M A

2007-08-01

209

POLLUTION DETECTION DOGS: PROOF OF CONCEPT  

EPA Science Inventory

Dogs have been used extensively in law enforcement and military applications to detect narcotics and explosives for over thirty years. Dogs are regularly used in arson investigations to detect accelerants since they are much more accurate at discriminating between accelerants an...

210

Cultivable Oral Microbiota of Domestic Dogs  

Microsoft Academic Search

Bacteria were isolated from the dental plaques of nine dogs and a sample of pooled saliva from five other dogs and were then identified by comparative 16S rRNA gene sequencing. Among 339 isolates, 84 different phylotypes belonging to 37 genera were identified. Approximately half of the phylotypes were identified to the species level, and 28% of these were considered members

David R. Elliott; Michael Wilson; Catherine M. F. Buckley; David A. Spratt

2005-01-01

211

Prevalence of dental disorders in pet dogs  

Microsoft Academic Search

Oral disorders of the dog represent for veterinarians a medical challenge and an important field of interest from the economical point of view. Although many epidemiological studies on dental diseases in beagles bred under controlled conditions have been realized, information on frequency of these alterations in populations of pet dogs, especially in Central Europe, is far from complete. The aim

M. Kyllar; K. Witter

212

Training Shelter Volunteers to Teach Dog Compliance  

ERIC Educational Resources Information Center

This study examined the degree to which training procedures influenced the integrity of behaviorally based dog training implemented by volunteers of an animal shelter. Volunteers were taught to implement discrete-trial obedience training to teach 2 skills (sit and wait) to dogs. Procedural integrity during the baseline and written instructions…

Howard, Veronica J.; DiGennaro Reed, Florence D.

2014-01-01

213

The Domestication of Social Cognition in Dogs  

Microsoft Academic Search

Dogs are more skillful than great apes at a number of tasks in which they must read human communicative signals indicating the location of hidden food. In this study, we found that wolves who were raised by humans do not show these same skills, whereas domestic dog puppies only a few weeks old, even those that have had little human

Brian Hare; Michelle Brown; Christina Williamson; Michael Tomasello

2002-01-01

214

Interactions of wolves and dogs in Minnesota  

USGS Publications Warehouse

This article reports on the nature and extent of wolf-dog interactions in Minnesota, based on investigations of complaints received by personnel of the federal government dealing with wolf-depredation control. Findings may indicate the wolf-dog interactions that can be expected in other recovery areas.

Fritts, S.H.; Paul, W.J.

1989-01-01

215

49 CFR 236.742 - Dog, locking.  

Code of Federal Regulations, 2014 CFR

...Transportation 4 2014-10-01 2014-10-01 false Dog, locking. 236.742 Section 236.742 Transportation...SYSTEMS, DEVICES, AND APPLIANCES Definitions § 236.742 Dog, locking. A steel block attached to a locking bar or...

2014-10-01

216

A Folk Tale of a Dog  

E-print Network

Folk Tale of a Dog Translation of title Description (to be used in archive entry) Tshe 'dzin tells a folktale in which a dog helps three girls escape from a demon. Genre or type (i.e. epic, song, ritual) Folktale Name of recorder (if...

Bkra shis bzang po

2009-11-17

217

49 CFR 236.742 - Dog, locking.  

Code of Federal Regulations, 2011 CFR

...Transportation 4 2011-10-01 2011-10-01 false Dog, locking. 236.742 Section 236.742 Transportation...SYSTEMS, DEVICES, AND APPLIANCES Definitions § 236.742 Dog, locking. A steel block attached to a locking bar or...

2011-10-01

218

49 CFR 236.742 - Dog, locking.  

Code of Federal Regulations, 2012 CFR

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2012-10-01

219

49 CFR 236.742 - Dog, locking.  

Code of Federal Regulations, 2013 CFR

...Transportation 4 2013-10-01 2013-10-01 false Dog, locking. 236.742 Section 236.742 Transportation...SYSTEMS, DEVICES, AND APPLIANCES Definitions § 236.742 Dog, locking. A steel block attached to a locking bar or...

2013-10-01

220

Going to the 'Dogs' to Test Hypotheses.  

ERIC Educational Resources Information Center

Describes an alternative method for using live animals in the classroom. A toy dog, the "Trail Tracker Hound Dog" (manufactured by CPG Products Corporation, Cincinnati, Ohio), is used to encourage development of such skills as observation, hypothesis testing, and collection and analysis of scientific data. (Author/JN)

Kramm, Kenneth R.

1982-01-01

221

Hyperferritinemia in dogs with splenic hemangiosarcoma.  

PubMed

Serum ferritin concentration increases in dogs in association with various diseases. In this study, we measured serum ferritin levels in dogs with splenic masses, using a sandwich ELISA assay. Eleven dogs with hemangiosarcoma (HSA), six with hematoma, 1 with hemangioma and 3 with lymphoma were enrolled. All dogs with HSA had serum ferritin concentrations above the normal limit (1,357 ng/ml, mean + 2× standard deviation of normal). Increased serum ferritin concentrations have also been observed in few cases of hematoma, hemangioma and lymphoma. Therefore, hyperferritinemia is not specific for splenic HSA, but may have clinical usefulness as a sensitive test for the disease. Further evaluation of serum ferritin concentrations in dogs with splenic HSA is needed. PMID:23803459

Chikazawa, Seishiro; Hori, Yasutomo; Hoshi, Fumio; Kanai, Kazutaka; Ito, Naoyuki; Higuchi, Seiichi

2013-11-01

222

Hyperferritinemia in Dogs with Splenic Hemangiosarcoma  

PubMed Central

ABSTRACT Serum ferritin concentration increases in dogs in association with various diseases. In this study, we measured serum ferritin levels in dogs with splenic masses, using a sandwich ELISA assay. Eleven dogs with hemangiosarcoma (HSA), six with hematoma, 1 with hemangioma and 3 with lymphoma were enrolled. All dogs with HSA had serum ferritin concentrations above the normal limit (1,357 ng/ml, mean + 2× standard deviation of normal). Increased serum ferritin concentrations have also been observed in few cases of hematoma, hemangioma and lymphoma. Therefore, hyperferritinemia is not specific for splenic HSA, but may have clinical usefulness as a sensitive test for the disease. Further evaluation of serum ferritin concentrations in dogs with splenic HSA is needed. PMID:23803459

CHIKAZAWA, Seishiro; HORI, Yasutomo; HOSHI, Fumio; KANAI, Kazutaka; ITO, Naoyuki; HIGUCHI, Seiichi

2013-01-01

223

Dog models of naturally occurring cancer.  

PubMed

Studies using dogs provide an ideal solution to the gap in animal models for natural disease and translational medicine. This is evidenced by approximately 400 inherited disorders being characterized in domesticated dogs, most of which are relevant to humans. There are several hundred isolated populations of dogs (breeds) and each has a vastly reduced genetic variation compared with humans; this simplifies disease mapping and pharmacogenomics. Dogs age five- to eight-fold faster than do humans, share environments with their owners, are usually kept until old age and receive a high level of health care. Farseeing investigators recognized this potential and, over the past decade, have developed the necessary tools and infrastructure to utilize this powerful model of human disease, including the sequencing of the dog genome in 2005. Here, we review the nascent convergence of genetic and translational canine models of spontaneous disease, focusing on cancer. PMID:21439907

Rowell, Jennie L; McCarthy, Donna O; Alvarez, Carlos E

2011-07-01

224

Dog Models of Naturally Occurring Cancer  

PubMed Central

Studies using dogs provide an ideal solution to the gap in animal models of natural disease and translational medicine. This is evidenced by approximately 400 inherited disorders being characterized in domesticated dogs, most of which are relevant to humans. There are several hundred isolated populations of dogs (breeds) and each has vastly reduced genetic variation compared to humans; this simplifies disease mapping and pharmacogenomics. Dogs age five to eight-fold faster than humans, share environments with their owners, are usually kept until old age, and receive a high level of health care. Farseeing investigators recognized this potential and, over the last decade, developed the necessary tools and infrastructure to utilize this powerful model of human disease, including the sequencing of the dog genome in 2005. Here we review the nascent convergence of genetic and translational canine models of spontaneous disease, focusing on cancer. PMID:21439907

Rowell, Jennie L.; McCarthy, Donna O.; Alvarez, Carlos E.

2011-01-01

225

Presuming the influence of the media: teenagers? constructions of gender identity through sexual/romantic relationships and alcohol consumption  

PubMed Central

Using empirical data from group discussions and in-depth interviews with 13 to 15-year olds in Scotland, this study explores how teenagers’ alcohol drinking and sexual/romantic relationships were shaped by their quest for appropriate gendered identities. In this, they acknowledged the influence of the media, but primarily in relation to others, not to themselves, thereby supporting Milkie's ‘presumed media influence’ theory. Media portrayals of romantic/sexual relationships appeared to influence teenagers’ constructions of gender-appropriate sexual behaviour more than did media portrayals of drinking behaviour, perhaps because the teenagers had more firsthand experience of observing drinking than of observing sexual relationships. Presumed media influence may be less influential if one has experience of the behaviour portrayed. Drinking and sexual behaviour were highly interrelated: sexual negotiation and activities were reportedly often accompanied by drinking. For teenagers, being drunk or, importantly, pretending to be drunk, may be a useful way to try out what they perceived to be gender-appropriate identities. In sum, teenagers’ drinking and sexual/romantic relationships are primary ways in which they do gender and the media's influence on their perceptions of appropriate gendered behaviour is mediated through peer relationships. PMID:24443822

Hartley, Jane E K; Wight, Daniel; Hunt, Kate

2014-01-01

226

Subconjunctival hibernoma in a dog.  

PubMed

A 10-year-old, castrated male, German Shepherd mixed-breed dog was presented to Kansas State University Veterinary Health Center for evaluation of a subconjunctival swelling in the ventral fornix of the left orbit. The owner elected to pursue excision of the mass 2 years after initial consultation following a sudden change in the size and color of the lesion. An excisional biopsy was performed, and the mass along with its associated capsule were submitted to the Comparative Ocular Pathology Laboratory of Wisconsin for histopathologic evaluation, which confirmed the diagnosis of a hibernoma. Fourteen months following excision, the patient showed no evidence of tumor regrowth. PMID:24238154

Stuckey, Jane A; Rankin, Amy J; Romkes, Gwendolyna; Slack, Jessica; Kiupel, Matti; Dubielzig, Richard R

2015-01-01

227

MYOCARDIAL CONCENTRATIONS OF FATTY ACIDS IN DOGS WITH DILATED CARDIOMYOPATHY  

Technology Transfer Automated Retrieval System (TEKTRAN)

To compare the myocardial concentrations of fatty acids in dogs with dilated cardiomyopathy (DCM) with control dogs using myocardium from 7 dogs with DCM, 16 control dogs. Myocardial tissues were homogenized and total fatty acids extracted and converted to methyl esters. Myocardial fatty acids conce...

228

Animal Health Diagnostic Center Lyme Disease Multiplex Testing for Dogs  

E-print Network

Animal Health Diagnostic Center Lyme Disease Multiplex Testing for Dogs Background on Lyme disease and Lyme diagnostics in dogs Lyme disease is induced by the spirochete B. burgdorferi. Spirochetes are transmitted to dogs by infected ticks. Similar to humans, dogs are incidental, dead-end hosts for B

Keinan, Alon

229

KEEPING OURSELVES SAFE NEAR DOGS Kendal Shepherd (BVSc, CCAB, MRCVS)  

E-print Network

1 KEEPING OURSELVES SAFE NEAR DOGS Kendal Shepherd (BVSc, CCAB, MRCVS) Adapted for classroom use 2012 Dogs have lived in the company of humans for many thou- sands of years. The domestic dog remain in terms of body language and behaviour, the dog we know today is a very different animal compared

Little, Tony

230

Fluffiness of dog Fluffiness of towel Inferring Analogous Attributes  

E-print Network

Fluffiness of dog Fluffiness of towel = ?? Inferring Analogous Attributes Chao-Yeh Chen and Kristen dogs A striped dog? Yes. + Prediction3 ?? = Inferred attribute21 Learned category-sensitive attributes Dog Equine Spotted BrownStriped + - + - + - + - No training examples ?? Attribute Category No training

Grauman, Kristen

231

Gather information and determine the best dog for  

E-print Network

Gather information and determine the best dog for your family . Learn about proper care, grooming, and feeding of your dog. Create a plan to prevent your dog from getting lost and/or finding it if it gets lost. Purchase and use the appro- priate grooming equipment and techniques. Train your dog basic com

New Hampshire, University of

232

31 CFR 407.11 - Dogs and other animals.  

Code of Federal Regulations, 2013 CFR

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2013-07-01

233

36 CFR 504.10 - Dogs and other animals.  

Code of Federal Regulations, 2013 CFR

...Property 3 2013-07-01 2012-07-01 true Dogs and other animals. 504.10 Section 504.10...SMITHSONIAN INSTITUTION BUILDINGS AND GROUNDS § 504.10 Dogs and other animals. Dogs and other animals, except seeing-eye dogs,...

2013-07-01

234

36 CFR 504.10 - Dogs and other animals.  

Code of Federal Regulations, 2012 CFR

...Property 3 2012-07-01 2012-07-01 false Dogs and other animals. 504.10 Section 504.10...SMITHSONIAN INSTITUTION BUILDINGS AND GROUNDS § 504.10 Dogs and other animals. Dogs and other animals, except seeing-eye dogs,...

2012-07-01

235

36 CFR 520.11 - Dogs and other animals.  

Code of Federal Regulations, 2010 CFR

...Property 3 2010-07-01 2010-07-01 false Dogs and other animals. 520.11 Section 520.11...PARK OF THE SMITHSONIAN INSTITUTION § 520.11 Dogs and other animals. Dogs and other animals, except seeing-eye dogs,...

2010-07-01

236

36 CFR 520.11 - Dogs and other animals.  

Code of Federal Regulations, 2012 CFR

...Property 3 2012-07-01 2012-07-01 false Dogs and other animals. 520.11 Section 520.11...PARK OF THE SMITHSONIAN INSTITUTION § 520.11 Dogs and other animals. Dogs and other animals, except seeing-eye dogs,...

2012-07-01

237

31 CFR 407.11 - Dogs and other animals.  

Code of Federal Regulations, 2014 CFR

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2014-07-01

238

31 CFR 91.11 - Dogs and other animals.  

Code of Federal Regulations, 2010 CFR

...Treasury 1 2010-07-01 2010-07-01 false Dogs and other animals. 91.11 Section 91.11...BUREAU OF THE MINT BUILDINGS AND GROUNDS § 91.11 Dogs and other animals. Dogs and other animals, except seeing-eye dogs,...

2010-07-01

239

36 CFR 504.10 - Dogs and other animals.  

Code of Federal Regulations, 2011 CFR

...Property 3 2011-07-01 2011-07-01 false Dogs and other animals. 504.10 Section 504.10...SMITHSONIAN INSTITUTION BUILDINGS AND GROUNDS § 504.10 Dogs and other animals. Dogs and other animals, except seeing-eye dogs,...

2011-07-01

240

31 CFR 407.11 - Dogs and other animals.  

Code of Federal Regulations, 2011 CFR

...Treasury 2 2011-07-01 2011-07-01 false Dogs and other animals. 407.11 Section 407.11...TREASURY BUILDING AND THE TREASURY ANNEX § 407.11 Dogs and other animals. Dogs and other animals, except seeing-eye dogs,...

2011-07-01

241

36 CFR 520.11 - Dogs and other animals.  

Code of Federal Regulations, 2014 CFR

...Property 3 2014-07-01 2014-07-01 false Dogs and other animals. 520.11 Section 520.11...PARK OF THE SMITHSONIAN INSTITUTION § 520.11 Dogs and other animals. Dogs and other animals, except seeing-eye dogs,...

2014-07-01

242

4 CFR 25.12 - Dogs and other animals.  

Code of Federal Regulations, 2013 CFR

...Accounts 1 2013-01-01 2013-01-01 false Dogs and other animals. 25.12 Section 25.12...ACCOUNTABILITY OFFICE BUILDING AND ON ITS GROUNDS § 25.12 Dogs and other animals. Dogs and other animals, except seeing eye dogs or...

2013-01-01

243

4 CFR 25.12 - Dogs and other animals.  

Code of Federal Regulations, 2011 CFR

...Accounts 1 2011-01-01 2011-01-01 false Dogs and other animals. 25.12 Section 25.12...ACCOUNTABILITY OFFICE BUILDING AND ON ITS GROUNDS § 25.12 Dogs and other animals. Dogs and other animals, except seeing eye dogs or...

2011-01-01

244

36 CFR 520.11 - Dogs and other animals.  

Code of Federal Regulations, 2013 CFR

...Property 3 2013-07-01 2012-07-01 true Dogs and other animals. 520.11 Section 520.11...PARK OF THE SMITHSONIAN INSTITUTION § 520.11 Dogs and other animals. Dogs and other animals, except seeing-eye dogs,...

2013-07-01

245

36 CFR 504.10 - Dogs and other animals.  

Code of Federal Regulations, 2010 CFR

...Property 3 2010-07-01 2010-07-01 false Dogs and other animals. 504.10 Section 504.10...SMITHSONIAN INSTITUTION BUILDINGS AND GROUNDS § 504.10 Dogs and other animals. Dogs and other animals, except seeing-eye dogs,...

2010-07-01

246

36 CFR 504.10 - Dogs and other animals.  

Code of Federal Regulations, 2014 CFR

...Property 3 2014-07-01 2014-07-01 false Dogs and other animals. 504.10 Section 504.10...SMITHSONIAN INSTITUTION BUILDINGS AND GROUNDS § 504.10 Dogs and other animals. Dogs and other animals, except seeing-eye dogs,...

2014-07-01

247

31 CFR 407.11 - Dogs and other animals.  

Code of Federal Regulations, 2010 CFR

...Treasury 2 2010-07-01 2010-07-01 false Dogs and other animals. 407.11 Section 407.11...TREASURY BUILDING AND THE TREASURY ANNEX § 407.11 Dogs and other animals. Dogs and other animals, except seeing-eye dogs,...

2010-07-01

248

31 CFR 91.11 - Dogs and other animals.  

Code of Federal Regulations, 2012 CFR

...Treasury 1 2012-07-01 2012-07-01 false Dogs and other animals. 91.11 Section 91.11...BUREAU OF THE MINT BUILDINGS AND GROUNDS § 91.11 Dogs and other animals. Dogs and other animals, except seeing-eye dogs,...

2012-07-01

249

31 CFR 407.11 - Dogs and other animals.  

Code of Federal Regulations, 2012 CFR

...Treasury 2 2012-07-01 2012-07-01 false Dogs and other animals. 407.11 Section 407.11...TREASURY BUILDING AND THE TREASURY ANNEX § 407.11 Dogs and other animals. Dogs and other animals, except seeing-eye dogs,...

2012-07-01

250

31 CFR 91.11 - Dogs and other animals.  

Code of Federal Regulations, 2014 CFR

...Treasury 1 2014-07-01 2014-07-01 false Dogs and other animals. 91.11 Section 91.11...BUREAU OF THE MINT BUILDINGS AND GROUNDS § 91.11 Dogs and other animals. Dogs and other animals, except seeing-eye dogs,...

2014-07-01

251

36 CFR 520.11 - Dogs and other animals.  

Code of Federal Regulations, 2011 CFR

...Property 3 2011-07-01 2011-07-01 false Dogs and other animals. 520.11 Section 520.11...PARK OF THE SMITHSONIAN INSTITUTION § 520.11 Dogs and other animals. Dogs and other animals, except seeing-eye dogs,...

2011-07-01

252

31 CFR 91.11 - Dogs and other animals.  

Code of Federal Regulations, 2013 CFR

...Treasury 1 2013-07-01 2013-07-01 false Dogs and other animals. 91.11 Section 91.11...BUREAU OF THE MINT BUILDINGS AND GROUNDS § 91.11 Dogs and other animals. Dogs and other animals, except seeing-eye dogs,...

2013-07-01

253

4 CFR 25.12 - Dogs and other animals.  

Code of Federal Regulations, 2012 CFR

...Accounts 1 2012-01-01 2012-01-01 false Dogs and other animals. 25.12 Section 25.12...ACCOUNTABILITY OFFICE BUILDING AND ON ITS GROUNDS § 25.12 Dogs and other animals. Dogs and other animals, except seeing eye dogs or...

2012-01-01

254

4 CFR 25.12 - Dogs and other animals.  

Code of Federal Regulations, 2010 CFR

...Accounts 1 2010-01-01 2010-01-01 false Dogs and other animals. 25.12 Section 25.12...ACCOUNTABILITY OFFICE BUILDING AND ON ITS GROUNDS § 25.12 Dogs and other animals. Dogs and other animals, except seeing eye dogs or...

2010-01-01

255

4 CFR 25.12 - Dogs and other animals.  

Code of Federal Regulations, 2014 CFR

...Accounts 1 2014-01-01 2013-01-01 true Dogs and other animals. 25.12 Section 25.12...ACCOUNTABILITY OFFICE BUILDING AND ON ITS GROUNDS § 25.12 Dogs and other animals. Dogs and other animals, except seeing eye dogs or...

2014-01-01

256

31 CFR 91.11 - Dogs and other animals.  

Code of Federal Regulations, 2011 CFR

...Treasury 1 2011-07-01 2011-07-01 false Dogs and other animals. 91.11 Section 91.11...BUREAU OF THE MINT BUILDINGS AND GROUNDS § 91.11 Dogs and other animals. Dogs and other animals, except seeing-eye dogs,...

2011-07-01

257

Decline in human dog-bite cases during a street dog sterilisation programme in Jaipur, India.  

PubMed

Human dog-bite injuries are a major public health problem, particularly where there are large populations of free-roaming or street dogs. Dog bites are also the major source of human rabies infections. There is little information on the means to reduce these injuries. Monthly human animal-bite injury records from January 2003 to June 2011 were obtained from the main government hospital in Jaipur, India. The data were analysed and compared with records of pregnancy in street dogs in Jaipur obtained from a street dog sterilisation programme. Human animal-bite injuries showed a seasonal pattern which followed by approximately 10 weeks the seasonal peak of street dog breeding. The number of human animal bites has declined significantly since 2003. It is concluded that a street dog sterilisation programme can reduce human dog-bite injuries by reducing the maternal protective behaviour of the street dogs, as well as reducing the total size of the roaming dog population. PMID:23492927

Reece, J F; Chawla, S K; Hiby, A R

2013-05-01

258

Phylogenetic Distinctiveness of Middle Eastern and Southeast Asian Village Dog Y Chromosomes Illuminates Dog Origins  

PubMed Central

Modern genetic samples are commonly used to trace dog origins, which entails untested assumptions that village dogs reflect indigenous ancestry or that breed origins can be reliably traced to particular regions. We used high-resolution Y chromosome markers (SNP and STR) and mitochondrial DNA to analyze 495 village dogs/dingoes from the Middle East and Southeast Asia, along with 138 dogs from >35 modern breeds to 1) assess genetic divergence between Middle Eastern and Southeast Asian village dogs and their phylogenetic affinities to Australian dingoes and gray wolves (Canis lupus) and 2) compare the genetic affinities of modern breeds to regional indigenous village dog populations. The Y chromosome markers indicated that village dogs in the two regions corresponded to reciprocally monophyletic clades, reflecting several to many thousand years divergence, predating the Neolithic ages, and indicating long-indigenous roots to those regions. As expected, breeds of the Middle East and East Asia clustered within the respective regional village dog clade. Australian dingoes also clustered in the Southeast Asian clade. However, the European and American breeds clustered almost entirely within the Southeast Asian clade, even sharing many haplotypes, suggesting a substantial and recent influence of East Asian dogs in the creation of European breeds. Comparison to 818 published breed dog Y STR haplotypes confirmed this conclusion and indicated that some African breeds reflect another distinct patrilineal origin. The lower-resolution mtDNA marker consistently supported Y-chromosome results. Both marker types confirmed previous findings of higher genetic diversity in dogs from Southeast Asia than the Middle East. Our findings demonstrate the importance of village dogs as windows into the past and provide a reference against which ancient DNA can be used to further elucidate origins and spread of the domestic dog. PMID:22194840

Brown, Sarah K.; Pedersen, Niels C.; Jafarishorijeh, Sardar; Bannasch, Danika L.; Ahrens, Kristen D.; Wu, Jui-Te; Okon, Michaella; Sacks, Benjamin N.

2011-01-01

259

Presumed ocular bartonellosis  

Microsoft Academic Search

BACKGROUNDThe spectrum of diseases caused by Bartonella henselae continues to expand and ocular involvement during this infection is being diagnosed with increasing frequency.METHODSThe clinical features and visual prognosis for 13 patients with intraocular inflammatory disease and laboratory evidence of bartonellosis were investigated. There were nine patients with neuroretinitis and four with panuveitis with positive antibody titres against B henselae determined

F. T. Kerkhoff; J. M. Ossewaarde; W. S. de Loos; A. Rothova

1999-01-01

260

Quantum non-barking dogs  

NASA Astrophysics Data System (ADS)

Quantum weak measurements with states both pre- and post-selected offer a window into a hitherto neglected sector of quantum mechanics. A class of such systems involves time dependent evolution with transitions possible. In this paper we explore two very simple systems in this class. The first is a toy model representing the decay of an excited atom. The second is the tunneling of a particle through a barrier. The post-selection criteria are chosen as follows: at the final time, the atom remains in its initial excited state for the first example and the particle remains behind the barrier for the second. We then ask what weak values are predicted in the physical environment of the atom (to which no net energy has been transferred) and in the region beyond the barrier (to which the particle has not tunneled). Thus, just as the dog that didn't bark in Arthur Conan Doyle's story Silver Blaze gave Sherlock Holmes meaningful information about the dog's non-canine environment, here we probe whether the particle that has not decayed or has not tunneled can provide measurable information about physical changes in the environment. Previous work suggests that very large weak values might arise in these regions for long durations between pre- and post-selection times. Our calculations reveal some distinct differences between the two model systems.

Imari Walker, Sara; Davies, Paul C. W.; Samantray, Prasant; Aharonov, Yakir

2014-06-01

261

Three-Dimensional SEM Study of Arteriovenous Anastomoses in the Dog’s Tongue Using Corrosive Resin Casts  

Microsoft Academic Search

Arteriovenous anastomoses (AVAs) participate in the regulation of blood flow. Although it has been speculated that AVAs in the dog’s tongue play a role in the regulation of the body temperature, no published work is available on the structural characteristics of AVAs in the dog’s tongue. The purpose of the present investigation was therefore to determine the frequency of AVAs

Yoshiaki Kishi; Seigyo So; Youhei Harada; Kazuto Takahashi

1988-01-01

262

Review on Dog Rabies Vaccination Coverage in Africa: A Question of Dog Accessibility or Cost Recovery?  

PubMed Central

Background Rabies still poses a significant human health problem throughout most of Africa, where the majority of the human cases results from dog bites. Mass dog vaccination is considered to be the most effective method to prevent rabies in humans. Our objective was to systematically review research articles on dog rabies parenteral vaccination coverage in Africa in relation to dog accessibility and vaccination cost recovery arrangement (i.e.free of charge or owner charged). Methodology/Principal Findings A systematic literature search was made in the databases of CAB abstracts (EBSCOhost and OvidSP), Scopus, Web of Science, PubMed, Medline (EBSCOhost and OvidSP) and AJOL (African Journal Online) for peer reviewed articles on 1) rabies control, 2) dog rabies vaccination coverage and 3) dog demography in Africa. Identified articles were subsequently screened and selected using predefined selection criteria like year of publication (viz. ? 1990), type of study (cross sectional), objective(s) of the study (i.e. vaccination coverage rates, dog demographics and financial arrangements of vaccination costs), language of publication (English) and geographical focus (Africa). The selection process resulted in sixteen peer reviewed articles which were used to review dog demography and dog ownership status, and dog rabies vaccination coverage throughout Africa. The main review findings indicate that 1) the majority (up to 98.1%) of dogs in African countries are owned (and as such accessible), 2) puppies younger than 3 months of age constitute a considerable proportion (up to 30%) of the dog population and 3) male dogs are dominating in numbers (up to 3.6 times the female dog population). Dog rabies parenteral vaccination coverage was compared between “free of charge” and “owner charged” vaccination schemes by the technique of Meta-analysis. Results indicate that the rabies vaccination coverage following a free of charge vaccination scheme (68%) is closer to the World Health Organization recommended coverage rate (70%) than the achieved coverage rate in owner-charged dog rabies vaccination schemes (18%). Conclusions/Significance Most dogs in Africa are owned and accessible for parenteral vaccination against rabies if the campaign is performed “free of charge”. PMID:25646774

Jibat, Tariku; Hogeveen, Henk; Mourits, Monique C. M.

2015-01-01

263

Experimental infection of dogs with Sarcocystis from wapiti.  

PubMed

Ten domestic dogs became infected with Sarcocystis when fed simple portions of heart, esophagus and diaphragm from a two-year-old female wapiti (Cervus canadensis). The prepatent period was 14 days in all exposed dogs; the patent period ranged from 8 to 20 days. Neither the 10 control dogs, nor two dogs fed sporocysts collected from the infected dogs passed sporocysts within the study period. Sporocysts averaged 16.5 by 11.1 micron in size. PMID:113562

Margolin, J H; Jolley, W R

1979-04-01

264

How to Steal a Dog and Other Lessons in Life  

ERIC Educational Resources Information Center

In this article, the author relates how a lost dog gave her the idea for writing her book, "How to Steal a Dog." Her tale of serendipity began when she, a dog-lover, walked into a garden center near her home and saw a sign for a lost dog taped beside the cash register. She states that, although her story is about a girl who stole a dog and…

O'Connor, Barbara

2007-01-01

265

Characterization of dog interleukin-2 activity.  

PubMed

Proliferative activity of murine interleukin-2 (IL-2) dependent T cells (CTLL-2) was detected in the culture supernatant of canine peripheral blood lymphocytes (PBL) stimulated with phytohemagglutinin-P (PHA-P), and was defined as dog IL-2. The highest production of IL-2 was obtained under the conditions in which a PBL population of 2 x 10(6) cells/ml was stimulated with PHA-P at a concentration of 10 micrograms/ml at 38 degrees C for 48 hr. Dog IL-2 activity was significantly inhibited by heating at 65 degrees C, acidification under pH 4, alkalification over pH 10, and trypsin exposure. A peak of dog IL-2 activity was detected in the fraction with a molecular weight of approximately 31,000 by gel filtration. Long-term culture of canine lymphocytes was successful over 10 passages by using dog IL-2 with PHA-P-stimulation every 3 passages. The cultured cells mostly consisted of small- and medium-sized lymphocytes. These cells reacted to anti-dog thymocyte rabbit serum and anti-dog Thy-1 mouse monoclonal antibody. These cells were therefore considered to originate in T-lineage lymphocytes. Cytostasis of PBL from intact dogs reacting to canine transmissible venereal sarcoma cells was increased significantly when PBL was cultured for more than 30 days with homologous IL-2. PMID:8117817

Mizuno, S; Fujinaga, T; Hagio, M

1993-12-01

266

CT and MRI evaluation of skull bones and soft tissues in six cats with presumed acromegaly versus 12 unaffected cats.  

PubMed

Feline acromegaly is predominantly caused by an adenoma of the pituitary gland, resulting in excessive growth hormone and insulin-like growth factor (IGF-1) secretion. In advanced cases, cats will display prominent facial features and upper airway congestion secondary to bony and soft tissue proliferation. The purpose of this study was to describe CT and MRI characteristics of soft tissues and skull bones in six cats with presumed acromegaly and to compare findings with those observed in 12 unaffected cats. In the five acromegalic cats with CT or MRI evidence of a pituitary tumor, frontal bone thickness was greater than age-matched controls with and without a history of upper airway disease. These five cats also had evidence of soft tissue accumulation in the nasal cavity, sinuses, and pharynx. One cat with insulin-resistant diabetes mellitus, elevated IGF-1, and a normal pituitary size did not have evidence of frontal bone thickening or upper airway congestion. PMID:22703122

Fischetti, Anthony J; Gisselman, Kelly; Peterson, Mark E

2012-01-01

267

Are owners' reports of their dogs' 'guilty look' influenced by the dogs' action and evidence of the misdeed?  

PubMed

While dog owners claim that their dogs' greeting behaviour after having performed a misdeed indicates the dogs' 'guilt', current experimental evidence suggests that dogs show these 'guilty look' behaviours as a response to being scolded by their owners. Given reports that 'guilty look' behaviours are shown also in the absence of being scolded, we investigated whether the dogs' own actions or the evidence of a misdeed might serve as triggering cues. We manipulated whether or not dogs ate a 'forbidden' food item and whether or not the food was visible upon the owners' return. Based on their dogs' greeting behaviour, owners stated that their dog had eaten the food no more than expected by chance. In addition, dogs' greeting behaviours were not affected by their own action or the presence or absence of the food. Thus, our findings do not support the hypothesis that dogs show the 'guilty look' in the absence of a concurrent negative reaction by their owners. PMID:25562192

Ostoji?, Ljerka; Tkal?i?, Mladenka; Clayton, Nicola S

2015-02-01

268

Dog Experts' Brains Distinguish Socially Relevant Body Postures Similarly in Dogs and Humans  

PubMed Central

We read conspecifics' social cues effortlessly, but little is known about our abilities to understand social gestures of other species. To investigate the neural underpinnings of such skills, we used functional magnetic resonance imaging to study the brain activity of experts and non-experts of dog behavior while they observed humans or dogs either interacting with, or facing away from a conspecific. The posterior superior temporal sulcus (pSTS) of both subject groups dissociated humans facing toward each other from humans facing away, and in dog experts, a distinction also occurred for dogs facing toward vs. away in a bilateral area extending from the pSTS to the inferior temporo-occipital cortex: the dissociation of dog behavior was significantly stronger in expert than control group. Furthermore, the control group had stronger pSTS responses to humans than dogs facing toward a conspecific, whereas in dog experts, the responses were of similar magnitude. These findings suggest that dog experts' brains distinguish socially relevant body postures similarly in dogs and humans. PMID:22720054

Kujala, Miiamaaria V.; Kujala, Jan; Carlson, Synnöve; Hari, Riitta

2012-01-01

269

Metastasizing Esthesioneuroblastoma in a Dog.  

PubMed

A 7-year-old Afghan hound presented with a history of disorientation, loss of vision, and seizures. Magnetic resonance imaging helped identify a mass at the level of the main olfactory bulb that compressed and displaced adjacent tissues in the cribriform plate into the nasal cavity and nasopharynx. Bony structures were osteolytic. After removing almost 80% of the mass, the tumor recurred a few months later. Due to severe respiratory distress and subsequent to an ultrasound diagnosis of a liver tumor, the dog was euthanized. In addition to the nasal mass, a single nodule in the liver and multiple nodules in the lung were present. All masses had similar cell morphology and were diagnosed as metastasizing esthesioneuroblastoma. The neoplastic cells expressed neuron-specific enolase and chromogranin A, and a few cells within the nasal mass were positive for cytokeratin. This is the first description of a canine esthesioneuroblastoma with distant metastases. PMID:25428407

Siudak, K; Klingler, M; Schmidt, M J; Herden, C

2014-11-26

270

Pathology Case Study: Dog Bites  

NSDL National Science Digital Library

This is a case study presented by the University of Pittsburgh Department of Pathology, which describes a 56-year-old male with a past medical history significant for lymphoma (in remission). The patient is a health care worker who presented to the emergency room because of a dog bite. Visitors are given a patient history and culture findings, including images. They are also given an opportunity to diagnose the patient before clicking on the "Final Diagnosis" section, which provides a discussion of the findings as well as references. This is an excellent resource for students in the health sciences to familiarize themselves with using patient history and laboratory results to diagnose disease. It is also a helpful site for educators to use to introduce or test student learning in clinical microbiology.

Driscoll, Eileen

271

Pemoline toxicosis in a dog.  

PubMed

A 3-year-old German Short-haired Pointer was examined because of extreme agitation, hyperactivity, and vomiting that began within 24 hours after ingestion of approximately 750 mg of pemoline, a CNS stimulant. On physical examination, the dog was agitated, tachycardic, hyper-responsive, pyrectic, disoriented, and had mydriasis. These signs were consistent with excessive stimulation of the CNS and sympathomimetic effects resulting from pemoline toxicosis. Serial blood and urine samples were obtained, and toxicologic analyses were performed. Extrapolation of the plasma pemoline concentration 32 hours after ingestion provided an estimated peak plasma concentration of 368 micrograms/ml, dramatically higher than a therapeutic concentration of 1.7 to 7.0 micrograms/ml reported for children. Several sedatives were administered intravenously to alleviate clinical signs and to allow administration of activated charcoal (PO) and fluids (IV). Clinical signs resolved approximately 72 hours after ingestion of pemoline. PMID:9426782

Cudia, S P; Poppenga, R H; Birdsall, W J

1998-01-01

272

Theileria annae in a young Swedish dog.  

PubMed

A severe regenerative anemia was detected in a 12-week-old mixed breed puppy in Sweden. A small protozoan parasite was observed in erythrocytes on a blood smear. It was initially suspected to be Babesia gibsoni based on its size and because B. gibsoni was previously recorded in Sweden. Surprisingly, specific polymerase chain reaction analysis identified the protozoan as Theileria annae. T. annae is endemic in Northwest Spain, is very uncommonly reported elsewhere and has never been recorded in Scandinavia. T. annae has been identified in dogs used for dog fighting, and it is thought to be transmitted by dog bites. This puppy was a mixed pit bull terrier. Pit bull terriers are sometimes used for dog fighting. T. annae has been reported to be transmitted vertically, and in light of the puppy's age, this transmission was suspected in the present case. PMID:23842507

Falkenö, Ulrika; Tasker, Séverine; Osterman-Lind, Eva; Tvedten, Harold W

2013-01-01

273

Dog DNA---A Recipe for Traits  

NSDL National Science Digital Library

Students will discover how DNA will "code" for traits by performing a lab activity where segments of paper DNA (genes) are picked at random, a list of traits is made, and a dog is drawn featuring its genetic traits.

Tanya Perrault

2012-02-20

274

Theileria annae in a young Swedish dog  

PubMed Central

A severe regenerative anemia was detected in a 12-week-old mixed breed puppy in Sweden. A small protozoan parasite was observed in erythrocytes on a blood smear. It was initially suspected to be Babesia gibsoni based on its size and because B. gibsoni was previously recorded in Sweden. Surprisingly, specific polymerase chain reaction analysis identified the protozoan as Theileria annae. T. annae is endemic in Northwest Spain, is very uncommonly reported elsewhere and has never been recorded in Scandinavia. T. annae has been identified in dogs used for dog fighting, and it is thought to be transmitted by dog bites. This puppy was a mixed pit bull terrier. Pit bull terriers are sometimes used for dog fighting. T. annae has been reported to be transmitted vertically, and in light of the puppy’s age, this transmission was suspected in the present case. PMID:23842507

2013-01-01

275

Comparison of P-wave dispersion in healthy dogs, dogs with chronic valvular disease and dogs with disturbances of supraventricular conduction  

PubMed Central

Background P-wave dispersion (Pd) is a new ECG index used in human cardiology and veterinary medicine. It is defined as the difference between the maximum and the minimum P-wave duration recorded from multiple different ECG leads. So far no studies were performed assessing the importance of P-wave dispersion in dogs. Methods The current study was aimed at determining proper value of Pd in healthy dogs (group I), dogs with chronic valvular disease (group II) and dogs with disturbances of supraventricular conduction (group III). The tests were carried out in 53 healthy dogs, 23 dogs with chronic valvular disease and 12 dogs with disturbances of supraventricular conduction of various breeds, sexes and body weight from 1,5 to 80 kg, aged between 0,5 and 17 years, submitted to the ECG examination. ECG was acquired in dogs in a standing position with BTL SD-8 electrocardiographic device and analyzed once the recording was enlarged. P-wave duration was calculated in 9 ECG leads (I, II, III, aVR, aVL, aVF, V1, V2, V4) from 5 cardiac cycles. Results The proper P-wave dispersion in healthy dogs was determined at up to 24 ms. P-wave dispersion was statistically significant increased (p < 0.01) in dogs with chronic valvular disease and dogs with disturbances of supraventricular conduction. In dogs with the atrial enlargement the P-wave dispersion is also higher than in healthy dogs, although no significant correlation between the size of left atria and Pd was noticed (p = 0.1, r = 0,17). Conclusions The P-wave dispersion is a constant index in healthy dogs, that is why it can be used for evaluating P wave change in dogs with chronic valvular disease and in dogs with disturbances of supraventricular conduction. PMID:21396110

2011-01-01

276

Assortative mating and fragmentation within dog breeds  

PubMed Central

Background There are around 400 internationally recognized dog breeds in the world today, with a remarkable diversity in size, shape, color and behavior. Breeds are considered to be uniform groups with similar physical characteristics, shaped by selection rooted in human preferences. This has led to a large genetic difference between breeds and a large extent of linkage disequilibrium within breeds. These characteristics are important for association mapping of candidate genes for diseases and therefore make dogs ideal models for gene mapping of human disorders. However, genetic uniformity within breeds may not always be the case. We studied patterns of genetic diversity within 164 poodles and compared it to 133 dogs from eight other breeds. Results Our analyses revealed strong population structure within poodles, with differences among some poodle groups as pronounced as those among other well-recognized breeds. Pedigree analysis going three generations back in time confirmed that subgroups within poodles result from assortative mating imposed by breed standards as well as breeder preferences. Matings have not taken place at random or within traditionally identified size classes in poodles. Instead, a novel set of five poodle groups was identified, defined by combinations of size and color, which is not officially recognized by the kennel clubs. Patterns of genetic diversity in other breeds suggest that assortative mating leading to fragmentation may be a common feature within many dog breeds. Conclusion The genetic structure observed in poodles is the result of local mating patterns, implying that breed fragmentation may be different in different countries. Such pronounced structuring within dog breeds can increase the power of association mapping studies, but also represents a serious problem if ignored. In dog breeding, individuals are selected on the basis of morphology, behaviour, working or show purposes, as well as geographic population structure. The same processes which have historically created dog breeds are still ongoing, and create further subdivision within current dog breeds. PMID:18226210

2008-01-01

277

Antitussive effects of levodropropizine in the dog.  

PubMed

The antitussive activity of levodropropizine (S(-)3-(4-phenyl-piperazine-1-yl)-propane-1,2-diol, DF 526, CAS 99291-25-5) was evaluated after oral administration to the conscious dog. Levodropropizine had a good antitussive activity, comparable with, but having a longer duration of action than dropropizine, the racemate from which it is derived. The antitussive activity of levodropropizine in the dog was approximately 1/20 of that of codeine phosphate. PMID:8147948

Munt, P L; Clavenna, G; Algate, D R; Leach, R M

1994-02-01

278

Serum protein electrophoresis in 147 dogs  

Microsoft Academic Search

Reference intervals for serum protein electrophoresis (SPE) were created from a group of 75 clinically healthy dogs and compared with SPE results obtained from clinical cases presented to the University of Bristol over an eight-and-a-half-year period. A total of 147 dogs, in which SPE had been performed, had complete case records available and thus met the inclusion criteria. Signalment and

S. W. Tappin; S. S. Taylor; S. Tasker; S. J. Dodkin; K. Papasouliotis; K. F. Murphy

2011-01-01

279

WILDLIFE RESPONSES TO PEDESTRIANS AND DOGS  

Microsoft Academic Search

ABSTRACT We measured the responses of two grassland passerines, one forest passerine, and one large mammal exposed to recreational treatments both on- and off-trail, including a pedestrian alone, a pedestrian accompanied by a dog-on-leash, and a dog alone. Responses measured included flush response (whether the animal flushed or not), flush distance (distance between disturbance and animal when flushed), distance of

Richard L. Knight

280

Magma-plumbing System of Asama Volcano after 2004 Eruption, Estimated from Vertical Deformation above the Presumed Pressure Sources  

NASA Astrophysics Data System (ADS)

Asama volcano is one of the active volcanoes in Japan, and it erupted on September 1, 2004. A shallow dike intrusion is estimated in the Takamine, 4 - 5 km west of the Asama crater from the ground deformation detected by GPS measurements (Aoki et al., 2005). Ground deformation observation close to the pressure source should clarify the depth and volume change of pressure sources. We establish the precise leveling routes ranging to Mt. Takamine above the presumed pressure source from Oiwake, at the southern foot of Asama volcano in May 2005.The precise levelings have practiced seven times for five years since May 2005 to June 2011. We calculated the vertical deformation for six-months or two-years between leveling epochs. Generally, deformations detected by the precise leveling are small of 10 mm. Deformations detected in the periods of May 2005 - Nov.2005. - May 2006 - May 2009 - June 2010 - June 2011, are grouping two patterns. One is definite subsidence, and another is slight uplift. Murakami (2005) discusses the line length changes between two GPS sites of Tsumagoi and Tobu, and he shows that the extension of line length just before the eruption in 2004 and 2009 and contraction between the eruption. Slight uplifts in the periods of May 2005 - May 2006 are corresponding to the period observed the extension, and subsidence in the periods of May 2006 - May 2007, May 2009 - June 2010, and June 2010 - June 2011. Two pressures sources are estimated from the ground deformation detected by precise leveling. One is a deeper spherical deflation source in the 6 km BSL depth beneath the mountainside, and another is the shallow dike intrusion beneath Mt. Takamine. A pressure source model was previously estimated from the leveling data for last 100 years (Murase et al., 2007), and it is suggestive a dominant source of the Asama volcano. They suggest a slight inflation after 1960, however our results show the deflation of -6.6 km3/6yr in the deeper sources for five years after the 2004 eruption. A shallow pressure source at 1.3 km BSL depth is corresponded to the presumed dike intrusion in 2004 eruption. It is very difficult to discuss the volume change of the dike, because of insignificant identification of dike length and width. Since May 2009, large deformation of 10 mm uplift and subsidence are detected around Mt. Takamine. It is suggested a drain back in May 2009 - June 2010 and an intrusion in June 2010 - June 2011.

Kimata, F.

2012-12-01

281

Efficacy of Malarone® in Dogs Naturally Infected with Babesia gibsoni  

PubMed Central

ABSTRACT The efficacy of Malarone® alone and in combination with doxycycline (DOXY) against Babesia gibsoni infections was examined in 8 dogs. In all dogs except one treated with Malarone®, parasitemia decreased, and anemia improved soon after initiation of treatment. However, 3 of 4 dogs treated with Malarone® relapsed, and relapse was inhibited in 2 of 4 dogs treated with Malarone® and DOXY. All relapsed dogs responded well to the second treatment, but 1 dog relapsed again and did not respond to the third treatment. Malarone® may be useful for acute stage of B. gibsoni infections, and at least second repeating treatment might be effective. PMID:24909969

IGUCHI, Aiko; SHIRANAGA, Nobuyuki; MATSUU, Aya; HIKASA, Yoshiaki

2014-01-01

282

Efficacy of Malarone(®) in dogs naturally infected with Babesia gibsoni.  

PubMed

The efficacy of Malarone(®) alone and in combination with doxycycline (DOXY) against Babesia gibsoni infections was examined in 8 dogs. In all dogs except one treated with Malarone(®), parasitemia decreased, and anemia improved soon after initiation of treatment. However, 3 of 4 dogs treated with Malarone(®) relapsed, and relapse was inhibited in 2 of 4 dogs treated with Malarone(®) and DOXY. All relapsed dogs responded well to the second treatment, but 1 dog relapsed again and did not respond to the third treatment. Malarone(®) may be useful for acute stage of B. gibsoni infections, and at least second repeating treatment might be effective. PMID:24909969

Iguchi, Aiko; Shiranaga, Nobuyuki; Matsuu, Aya; Hikasa, Yoshiaki

2014-09-01

283

Contact with Domestic Dogs Increases Pathogen Exposure in Endangered African Wild Dogs (Lycaon pictus)  

PubMed Central

Background Infectious diseases have contributed to the decline and local extinction of several wildlife species, including African wild dogs (Lycaon pictus). Mitigating such disease threats is challenging, partly because uncertainty about disease dynamics makes it difficult to identify the best management approaches. Serious impacts on susceptible populations most frequently occur when generalist pathogens are maintained within populations of abundant (often domestic) “reservoir” hosts, and spill over into less abundant host species. If this is the case, disease control directed at the reservoir host might be most appropriate. However, pathogen transmission within threatened host populations may also be important, and may not be controllable by managing another host species. Methodology/Principal Findings We investigated interspecific and intraspecific transmission routes, by comparing African wild dogs' exposure to six canine pathogens with behavioural measures of their opportunities for contact with domestic dogs and with other wild dogs. Domestic dog contact was associated with exposure to canine parvovirus, Ehrlichia canis, Neospora caninum and perhaps rabies virus, but not with exposure to canine distemper virus or canine coronavirus. Contact with other wild dogs appeared not to increase the risk of exposure to any of the pathogens. Conclusions/Significance These findings, combined with other data, suggest that management directed at domestic dogs might help to protect wild dog populations from rabies virus, but not from canine distemper virus. However, further analyses are needed to determine the management approaches – including no intervention – which are most appropriate for each pathogen. PMID:22238695

Woodroffe, Rosie; Prager, Katherine C.; Conrad, Patricia A.; Dubovi, Edward J.; Mazet, Jonna A. K.

2012-01-01

284

Who Let the Dog in? How to Incorporate a Dog into a Self-Contained Classroom  

ERIC Educational Resources Information Center

Described in this article are outcomes, procedures, and suggestions for incorporating a dog into a classroom for students with emotional or behavioral disorders. First, the outcomes for the inclusion of a dog are presented and are reported from an empirical study conducted by the author. Next, details are provided on how teachers would initially…

Anderson, Katherine L.

2007-01-01

285

A case of presumably Rathke's cleft cyst associated with postoperative cerebrospinal fluid leakage through persisting embryonal infundibular recess.  

PubMed

Persisting embryonal infundibular recess (PEIR) is a rare anomaly of the third ventricular floor. Only eight cases have been published. In this report, a case of presumably Rathke's cleft cyst associated with cerebrospinal fluid leakage caused by PEIR is described. An 81-year-old woman underwent endoscopic transsphenoidal surgery for the intra- and supra-sellar cystic lesion. Intraoperatively a hole was confirmed over the sella turcica connecting the sellar cyst and the infundibular recess. Liquorrhea did not occur throughout the procedure. A computed tomography (CT) scan obtained immediately after surgery disclosed accumulation of air in the third and lateral ventricles, in addition to the intra- and supra-sellar region. Air accumulation resolved spontaneously after bed rest for 11 days and she was discharged without neurological deficits. However, she required the second transsphenoidal surgery to repair the sellar floor because of bacterial meningitis caused by liquorrhea on the postoperative day 23. A postoperative 3-tesla magnetic resonance image revealed a deep infundibular recess connecting the sella turcica and the third ventricle, which was considered to be PEIR. To the best our knowledge, this is the first reported case describing the intraoperative findings of PEIR. PMID:24305020

Kuroiwa, Masafumi; Kusano, Yoshikazu; Ogiwara, Toshihiro; Tanaka, Yuichiro; Takemae, Toshiki; Hongo, Kazuhiro

2014-01-01

286

Infant death presumably due to exertional self-overheating in bed: an autopsy case of suspected child abuse.  

PubMed

We report a case of accidental infant death presumably due to exertional self-overheating in bed. On a winter morning, a 9-month-old female baby was found dead in her bed at home. She had been confined to the bed overnight by her father, totally covered with a blanket and a thick quilt, because her night crying disturbed his sleep. The clothing and bedclothes were extremely wet with sweat. Many petechial hemorrhages were observed in the upper chest and thoracic viscera. The blood was concentrated, indicative of dehydration. Histological and immunohistochemical investigation revealed findings of shock and myolysis in the cardiac and skeletal muscles. There was no evidence of natural diseases. The main cause of death was diagnosed as circulatory collapse from overheating (hyperpyrexia and dehydration; heat stroke/exhaustion) probably precipitated by struggling in the closed space. Although there was no apparent evidence of battering or any other repetitive physical violence, this case was regarded as an atypical type of fatal child abuse. PMID:9711068

Zhu, B L; Ishida, K; Fujita, M Q; Maeda, H

1998-04-01

287

Sperm retrieval and live birth rates in presumed Sertoli-cell-only syndrome in testis biopsy: a single centre experience.  

PubMed

We aimed to investigate sperm retrieval rates (SRR) by testicular sperm extraction (TESE), factors affecting SRR, and fertilization rate (FR), implantation rate (IR), clinical pregnancy rate (CPR) and live birth rate (LBR) in patients with presumed Sertoli-cell-only syndrome in testis biopsy (SCOS). We retrospectively evaluated files of 134 patients with SCOS who underwent TESE. Group I were patients in whom spermatozoa were retrieved and Group II were patients in whom no spermatozoa could be retrieved. SRR, Follicle stimulating hormone (FSH), Luteinizing hormone (LH), and testosterone levels, and the volume of testicles were compared between groups. In addition, FR, IR, CPR and LBR were determined. Sperm retrieval was achieved in 37 (27.6%) patients (Group I), and the remaining 97 (72.4%) patients made Group II. There were no significant differences in age, infertility time, testicular volume, serum FSH, LH and testosterone levels between Groups I and II (p > 0.05). Intracytoplasmic sperm injection (ICSI) was performed in 36 patients. FR, IR, and CPR were 60.86 ± 23.03, 36.53 ± 41.78 and 51.3% respectively. Cycle and patient based LBRs were 37.8 and 45.1% respectively. SRR in SCOS is lower than patients with non-obstructive azoospermia (NOA) in general. No parameters to predict spermatozoa retrieval were determined. In patients with SCOS, ICSI achieves similar live birth rate to other patients with NOA. PMID:23258629

Gul, U; Turunc, T; Haydardedeoglu, B; Yaycioglu, O; Kuzgunbay, B; Ozkardes, H

2013-01-01

288

Herb induced liver injury presumably caused by black cohosh: a survey of initially purported cases and herbal quality specifications.  

PubMed

Herb induced liver injury (HILI) is a particular challenge that also applies to purported cases presumably caused by black cohosh (BC), an herb commonly used to treat menopausal symptoms. We analyzed and reviewed all published case reports and spontaneous reports of initially alleged BC hepatotoxicity regarding quality of case details and causality assessments. Shortcomings of data quality were more evident in spontaneous reports of regulatory agencies compared to published case reports, but assessments with the scale of CIOMS (Council for the International Organizations of Sciences) or its updated version revealed lack of causality for BC in all cases. The applied causality methods are structured, quantitative, and liver specific with clear preference over an ad hoc causality method or the liver unspecific Naranjo scale. Reviewing the case data and the reports dealing with quality specifications of herbal BC products, there is general lack of analysis with respect to authentication of BC in the BC products used by the patients. However, in one single regulatory study, there was a problem of BC authentication in the analysed BC products, and other reports addressed the question of impurities and adulterants in a few BC products. It is concluded that the use of BC may not exert an overt hepatotoxicity risk, but quality problems in a few BC products were evident that require additional regulatory quality specifications. PMID:21677326

Teschke, Rolf; Schwarzenboeck, Alexander; Schmidt-Taenzer, Wolfgang; Wolff, Albrecht; Hennermann, Karl-Heinz

2011-01-01

289

Spirocercosis in owned and stray dogs in Grenada.  

PubMed

The aim of this retrospective study was to estimate the prevalence of Spirocerca lupi and its associated lesions in owned and stray dogs in Grenada. During 2001-2011 necropsies were carried out on 1022 owned and 450 stray dogs at the pathology diagnostic laboratory, School of Veterinary Medicine, St. George's University, Grenada. Lesions due to S. lupi characterized by focal to multifocal granulomatous esophagitis with aneurysms, mineralized plaques and nodules in the adjacent thoracic aorta were found in 90 (8.8%; 95% confidence interval, 7.1-10.5%) of owned dogs and 64 (14.2%; 95% CI, 11.2-17.6%) of stray dogs. Stray dogs were significantly more affected by spirocercosis than owned dogs (p=0.0022). Of the 90 owned dogs with spirocercosis, 3 dogs had aberrant migration to the thoracic vertebral column with resultant spondylitis; 1 dog each had aberrant migration involving the stomach and the lung. Two dogs had ruptured aorta with hemothorax. Among the 64 stray dogs with spirocercosis, one dog had an esophageal granuloma that transformed into a fibroblastic osteosarcoma; spondylitis due to aberrant migration of S. lupi and hypertrophic osteopathy. We report spirocercosis for the first time in the dogs from a tropical island of Grenada. PMID:22841904

Chikweto, A; Bhaiyat, M I; Tiwari, K P; de Allie, C; Sharma, R N

2012-12-21

290

Molecular Genetic Diversity of the Gyeongju Donggyeong Dog in Korea  

PubMed Central

ABSTRACT The present study was conducted to analyze the genetic characteristics of the Donggyeong dog and establish parentage conservation systems for it by using 10 microsatellite markers recommended by the International Society for Animal Genetics (ISAG). A total of 369 dogs from 12 dog breeds including the Donggyeong dog were genotyped using 10 microsatellite loci. The number of alleles per locus varied from 5 to 10 with a mean value of 7.6 in the Donggyeong dog. The observed heterozygosity and expected heterozygosity ranged from 0.4706 to 0.9020 (mean 0.7657) and from 0.4303 to 0.8394 (mean 0.7266), respectively. The total exclusion probability of 10 microsatellite loci was 0.99955. Of the 10 microsatellite markers, the AHT121, AHTh260 and CXX279 markers had relatively high PIC values (?0.7). This study found that there were specific alleles, 116 allele at AHT121 in the Donggyeong dog when compared with other dog breeds. Also, the results showed two (Korean native dogs and the foreign dog breeds) distinct clusters. The closest distance (0.1184) was observed between the Donggyeong dog and Jindo dog, and the longest distance (0.3435) was observed between the Donggyeong dog and Bulgae. The Korean native dog breeds have comparatively near genetic distances between each other. PMID:25030603

LEE, Eun-Woo; CHOI, Seong-Kyoon; CHO, Gil-Jae

2014-01-01

291

Dogs and their human companions: the effect of familiarity on dog-human interactions.  

PubMed

There are few quantitative examinations of the extent to which dogs discriminate between familiar and unfamiliar persons. In our study we have investigated whether dogs show differential behaviour towards humans of different degrees of familiarity (owner, familiar person, unfamiliar person). Dogs and humans were observed in eight test situations: (1) Three-way strange situation test, (2) Calling in from food, (3) Obedience test, (4) Walking away, (5) Threatening approach, (6) Playful interaction, (7) Food inhibition test and (8) Manipulation of the dog's body. Dogs distinguished between the owner and the two other test partners in those tests which involved separation from the owner (Test 1, 4), were aversive for the dog (Test 5) or involved playing interaction (Test 6). Our results revealed that the owner cannot be replaced by a familiar person in situations provoking elevated anxiety and fear. In contrasts, dogs did not discriminate between the owner and the familiar person in those tests that were based on obedient behaviour or behaviour towards an assertive person (Tests 2, 3, 7 and 8). Dogs' former training experience reduced the difference between their behaviour towards the owner and the familiar person in situations requiring obedience but it did not mask it totally. The dogs' behaviour towards each of the humans participating in the tests was consistent all over the test series. In summary, dogs discriminated between their owner and the unfamiliar person and always preferred the owner to the unfamiliar person. However, the discrimination between the owner and the familiar person is context-specific. This article is part of a Special Issue entitled: Canine Behavior. PMID:24548652

Kerepesi, Andrea; Dóka, Antal; Miklósi, Ádám

2015-01-01

292

Free segmental paw pad grafts in dogs.  

PubMed

After removal of 1 metatarsal pad and formation of a granulation tissue bed, free segmental 6- x 8-mm grafts from digital pads were sutured into recessed same-size recipient sites in the granulation tissue. In 5 dogs, the grafted area had been denervated by excision of a segment of the tibial nerve at the level of the tarsus. The grafted area was not denervated in the remaining 5 dogs. In both groups of dogs, the grafts placed around the periphery of the wound healed, blocked ingrowth of delicate epithelium from the surrounding skin, and provided a tough keratinized epithelium that covered the wound's center. As healing progressed, the grafts coalesced as the wounds contracted. Weight bearing resulted in graft expansion to provide functional weight-bearing tissue. Dogs of the denervated group had clinical and histologic evidence of collateral sensory reinnervation of the denervated area. However, with the exception of 1 dog, results of sensory nerve action potential tests indicated that reinnervation may not have been by way of regeneration across the excisional gap in the nerve. Evaluation of reinnervation of the tibial autonomous zone in 2 additional dogs revealed clinical evidence that collateral reinnervation began between 19 and 28 days after nerve excision and progressed proximad to distad. Results of sensory nerve action potential tests indicated that reinnervation may not have been via regeneration across the excision site. Results of fluorescent tracer studies did not have positive findings regarding the route of collateral reinnervation. Segmental paw pad grafts can be used effectively to provide weight-bearing tissue on a dog's limb. With local nerve damage on the distal portion of the limb, collateral innervation can grow into the area to reinnervate tissues, including pad grafts. PMID:8116954

Swaim, S F; Bradley, D M; Steiss, J E; Powers, R D; Buxton, D F

1993-12-01

293

Bounding on Rough Terrain with the LittleDog Robot  

E-print Network

A motion planning algorithm is described for bounding over rough terrain with the LittleDog robot. Unlike walking gaits, bounding is highly dynamic and cannot be planned with quasi-steady approximations. LittleDog is modeled ...

Shkolnik, Alexander C.

294

From Nanny Chips to Data Dogs, Binghamton innovations  

E-print Network

Binghamton ReseaRch From Nanny Chips to Data Dogs, Binghamton innovations will make computing safer Welcome 4 Briefs 8 Digital defenders From Nanny Chips to Data Dogs, Binghamton innovations will make

Suzuki, Masatsugu

295

Preference for copying unambiguous demonstrations in dogs (Canis familiaris).  

PubMed

In an earlier study (P. Pongracz et al., 2001), it was shown that human demonstration significantly enhances the detouring ability of dogs (Canis familiaris) around a V-shaped fence. The authors investigated the effect of the direction of the demonstrated detour and the dogs' detouring experience. They found that dogs' trial-and-error experience influences strongly the direction of the dogs' detours later, even if the demonstrator showed detours along the opposite side of the fence. However, dogs' preferences based on their own experiences were changed when the dogs observed demonstrations only on 1 side of the fence. Dogs with no trial-and-error experience followed the direction of 1-sided demonstrations. The change from dogs' own directions to the demonstrated directions seems not to be due to simple facilitative effects of social experience; the similarity with the demonstrated action depends on complex interactions between individual experience and socially provided information. PMID:14498810

Pongrácz, Péter; Miklósi, Adám; Timár-Geng, Katalin; Csányi, Vilmos

2003-09-01

296

A Study of Dog Bites and their Prevention   

E-print Network

Previous studies have suggested that children are more at risk of suffering from serious dog bite injuries than adults. In order to generate an overview of characteristics of dog bite victims in Europe, different ...

Lakestani, Nelly N

2007-01-01

297

9 CFR 3.8 - Exercise for dogs.  

Code of Federal Regulations, 2010 CFR

...AGRICULTURE ANIMAL WELFARE STANDARDS Specifications for the Humane Handling, Care, Treatment, and Transportation of Dogs and Cats 1 Animal Health and Husbandry Standards § 3.8 Exercise for dogs. Dealers, exhibitors, and research...

2010-01-01

298

9 CFR 3.8 - Exercise for dogs.  

Code of Federal Regulations, 2011 CFR

...AGRICULTURE ANIMAL WELFARE STANDARDS Specifications for the Humane Handling, Care, Treatment, and Transportation of Dogs and Cats 1 Animal Health and Husbandry Standards § 3.8 Exercise for dogs. Dealers, exhibitors, and research...

2011-01-01

299

9 CFR 3.8 - Exercise for dogs.  

Code of Federal Regulations, 2014 CFR

...AGRICULTURE ANIMAL WELFARE STANDARDS Specifications for the Humane Handling, Care, Treatment, and Transportation of Dogs and Cats 1 Animal Health and Husbandry Standards § 3.8 Exercise for dogs. Dealers, exhibitors, and research...

2014-01-01

300

9 CFR 3.8 - Exercise for dogs.  

Code of Federal Regulations, 2012 CFR

...AGRICULTURE ANIMAL WELFARE STANDARDS Specifications for the Humane Handling, Care, Treatment, and Transportation of Dogs and Cats 1 Animal Health and Husbandry Standards § 3.8 Exercise for dogs. Dealers, exhibitors, and research...

2012-01-01

301

9 CFR 3.8 - Exercise for dogs.  

Code of Federal Regulations, 2013 CFR

...AGRICULTURE ANIMAL WELFARE STANDARDS Specifications for the Humane Handling, Care, Treatment, and Transportation of Dogs and Cats 1 Animal Health and Husbandry Standards § 3.8 Exercise for dogs. Dealers, exhibitors, and research...

2013-01-01

302

WISE Discovers Hyperluminous Hot DOGs  

NASA Astrophysics Data System (ADS)

One of the primary science objectives for NASA's Wide-field Infrared Survey Explorer (WISE) is to find the most luminous galaxies in the Universe. We have used WISE photometry to select an extraordinary all-sky sample of galaxies, which are prominent at 12 microns (W3) or 22 microns (W4), but faint or undetected at 3.4 microns (W1) and 4.6 microns (W2). Follow-up observations reveal that most of these galaxies are at redshift > 1.5, that they are hyperluminous (> 10^13 Lsun; with ~10% exceeding 10^14 Lsun, comparable to the most luminous optical QSOs). The follow-up observations also show that they are at least twice as hot as other types of infrared luminous galaxies, so that they are hot dust-obscured-galaxies, or Hot DOGs. Their SEDs have a very high mid-IR to submillimeter luminosity ratio, which is quite different from any existing galaxy templates. They may represent a rare, new phase in the galaxy evolution, possibly hosting extremely powerful super massive black holes.

Eisenhardt, Peter R.; Wu, J.; WISE Team

2013-01-01

303

Self-regulatory depletion in dogs: insulin release is not necessary for the replenishment of persistence.  

PubMed

It has been hypothesized that self-control is constrained by a limited energy resource that can be depleted through exertion. Once depleted, this resource can be replenished by the consumption or even the taste of glucose. For example, the need to inhibit reduces subsequent persistence at problem solving by humans and dogs, an effect that is not observed when a glucose drink (but not a placebo) is administered following initial inhibition. The mechanism for replenishment by glucose is currently unknown. Energy transfer is not necessary, although insulin secretion may be involved. This possibility was investigated in the current study by having dogs exert self-control (sit-stay) and subsequently giving them (1) glucose that causes the release of insulin, (2) fructose that does not result in the release of insulin nor does it affect glucose levels (but it is a carbohydrate), or (3) a calorie-free drink. Persistence measures indicated that both glucose and fructose replenished canine persistence, whereas the calorie-free drink did not. These results indicate that insulin release is probably not necessary for the replenishment that is presumed to be responsible for the increase in persistence. This article is part of a Special Issue entitled: Canine Behavior. PMID:25264236

Miller, Holly C; Pattison, Kristina F; Laude, Jennifer R; Zentall, Thomas R

2015-01-01

304

Short-term synchrony in diverse motor nuclei presumed to receive different extents of direct cortical input  

PubMed Central

Motor units within human muscles usually exhibit a significant degree of short-term synchronization. Such coincident spiking typically has been attributed to last-order projections that provide common synaptic input across motor neurons. The extent of branched input arising directly from cortical neurons has often been suggested as a critical factor determining the magnitude of short-term synchrony. The purpose of this study, therefore, was to quantify motor unit synchrony in a variety of human muscles differing in the presumed extent of cortical input to their respective motor nuclei. Cross-correlation histograms were generated from the firing times of 551 pairs of motor units in 16 human muscles. Motor unit synchrony tended to be weakest for proximal muscles and strongest for more distal muscles. Previous work in monkeys and humans has shown that the strength of cortical inputs to motor neurons also exhibits a similar proximal-to-distal gradient. However, in the present study, proximal-distal location was not an exclusive predictor of synchrony magnitude. The muscle that exhibited the least synchrony was an elbow flexor, whereas the greatest synchrony was most often found in intrinsic foot muscles. Furthermore, the strength of corticospinal inputs to the abductor hallucis muscle, an intrinsic foot muscle, as assessed through transcranial magnetic stimulation, was weaker than that projecting to the tibialis anterior muscle, even though the abductor hallucis muscle had higher synchrony values compared with the tibialis anterior muscle. We argue, therefore, that factors other than the potency of cortical inputs to motor neurons, such as the number of motor neurons innervating a muscle, significantly affects motor unit synchrony. PMID:23019009

Keen, Douglas A.; Chou, Li-Wei; Nordstrom, Michael A.

2012-01-01

305

Dogs can discriminate human smiling faces from blank expressions  

Microsoft Academic Search

Dogs have a unique ability to understand visual cues from humans. We investigated whether dogs can discriminate between human\\u000a facial expressions. Photographs of human faces were used to test nine pet dogs in two-choice discrimination tasks. The training\\u000a phases involved each dog learning to discriminate between a set of photographs of their owner’s smiling and blank face. Of\\u000a the nine

Miho Nagasawa; Kensuke Murai; Kazutaka Mogi; Takefumi Kikusui

2011-01-01

306

Original article Chiral inversion of fenoprofen in horses and dogs  

E-print Network

Original article Chiral inversion of fenoprofen in horses and dogs: an in vivo-in vitro study geldings and three male beagle dogs, following intravenous doses of racemic FPF (1 mg/kg in horses), R(-)FPF (0.5 mg/kg in horses, 1 mg/kg in dogs), and S(+)FPF (0.5 mg/kg in horses, 1 mg/kg in dogs

Paris-Sud XI, Université de

307

Neoplastic lesions in the nasal cavities of dogs.  

PubMed

This paper aims at evaluating the frequency of nasal cavity tumors in dogs as well as comparing an endoscopic examination with a histopathological evaluation of the collected biopsy specimens. The study was conducted on 68 dogs. During the endoscopic examination, proliferative lesions were recognized in 20 dogs. During the histopathological examination, neoplastic lesions were confirmed in 95% of the dogs in which proliferative lesions were identified in the endoscopic examination. Adenocarcinoma occurred most frequently in the population under study. PMID:24988869

Spuzak, J; Jankowski, M; Kubiak, K; Gli?ska-Suchocka, K; Grzegory, M; Ha?o?, A

2014-01-01

308

Electroencephalographic studies of dogs with achalasia of the esophagus  

E-print Network

REFERENCES VITA PAGE V V11 V111 22 25 26 29 LIST OF TABLES TABLE PAGE 1 Summary of Animals Studied 10 LIST OF FIGURES FIGURE PAGE 10 Scout radiograph of achalastic dog showing air in esophagus (arrows) Barium radiograph of normal dog showing... traces of barium (arrows) in esophagus after swallowing Barium radiograph of achalastic dog with moderate dilation of the esophagus evident Barium radiograph of achalastic dog with severe dilation and sacculati on of esophagus Typical i ntrahemi...

Hall, Charles Lynn

1972-01-01

309

Mapping DNA structural variation in dogs  

PubMed Central

DNA structural variation (SV) comprises a major portion of genetic diversity, but its biological impact is unclear. We propose that the genetic history and extraordinary phenotypic variation of dogs make them an ideal mammal in which to study the effects of SV on biology and disease. The hundreds of existing dog breeds were created by selection of extreme morphological and behavioral traits. And along with those traits, each breed carries increased risk for different diseases. We used array CGH to create the first map of DNA copy number variation (CNV) or SV in dogs. The extent of this variation, and some of the gene classes affected, are similar to those of mice and humans. Most canine CNVs affect genes, including disease and candidate disease genes, and are thus likely to be functional. We identified many CNVs that may be breed or breed class specific. Cluster analysis of CNV regions showed that dog breeds tend to group according to breed classes. Our combined findings suggest many CNVs are (1) in linkage disequilibrium with flanking sequence, and (2) associated with breed-specific traits. We discuss how a catalog of structural variation in dogs will accelerate the identification of the genetic basis of canine traits and diseases, beginning with the use of whole genome association and candidate-CNV/gene approaches. PMID:19015322

Chen, Wei-Kang; Swartz, Joshua D.; Rush, Laura J.; Alvarez, Carlos E.

2009-01-01

310

Toxicity of Hydroxyurea in Rats and Dogs.  

PubMed

The toxicity of hydroxyurea, a treatment for specific neoplasms, sickle-cell disease, polycythemia, and thrombocytosis that kills cells in mitosis, was assessed in repeat-dose, oral gavage studies in rats and dogs and a cardiovascular study in telemetered dogs. Hydroxyurea produced hematopoietic, lymphoid, cardiovascular, and gastrointestinal toxicity with steep dose response curves. In rats dosed for 10 days, 50 mg/kg/day was tolerated; 500 mg/kg/day produced decreased body weight gain; decreased circulating leukocytes, erythrocytes, and platelets; decreased cellularity of thymus, lymph nodes, and bone marrow; and epithelial degeneration and/or dysplasia of the stomach and small intestine; 1,500 mg/kg/day resulted in deaths on day 5. In dogs, a single dose at ?250 mg/kg caused prostration leading to unscheduled euthanasia. Dogs administered 50 mg/kg/day for 1 month had decreased circulating leukocytes, erythrocytes, and platelets; increased bone marrow cellularity with decreased maturing granulocytes; increased creatinine kinase activity; and increased iron pigment in bone marrow and hepatic sinusoidal cells. In telemetered dogs, doses ?15 mg/kg decreased systolic blood pressure (BP); 50 mg/kg increased diastolic BP, heart rate, and change in blood pressure over time (+dP/dt), and decreased QT and PR intervals and maximum left ventricular systolic and end diastolic pressures with measures returning to control levels within 24 hr. PMID:25391310

Morton, Daniel; Reed, Lori; Huang, Wenhu; Marcek, John M; Austin-LaFrance, Robert; Northcott, Carrie A; Schelling, Scott H; Enerson, Bradley E; Tomlinson, Lindsay

2014-11-11

311

Oxytocin promotes social bonding in dogs  

PubMed Central

Recent evidence suggests that enduring social bonds have fitness benefits. However, very little is known about the neural circuitry and neurochemistry underlying the formation and maintenance of stable social bonds outside reproductive contexts. Oxytocin (OT), a neuropeptide synthetized by the hypothalamus in mammals, regulates many complex forms of social behavior and cognition in both human and nonhuman animals. Animal research, however, has concentrated on monogamous mammals, and it remains unknown whether OT also modulates social bonds in nonreproductive contexts. In this study we provide behavioral evidence that exogenous OT promotes positive social behaviors in the domestic dog toward not only conspecifics but also human partners. Specifically, when sprayed with OT, dogs showed higher social orientation and affiliation toward their owners and higher affiliation and approach behaviors toward dog partners than when sprayed with placebo. Additionally, the exchange of socio-positive behaviors with dog partners triggered the release of endogenous OT, highlighting the involvement of OT in the development of social relationships in the domestic dog. These data provide new insight into the mechanisms that facilitate the maintenance of close social bonds beyond immediate reproductive interest or genetic ties and complement a growing body of evidence that identifies OT as one of the neurochemical foundations of sociality in mammalian species. PMID:24927552

Romero, Teresa; Nagasawa, Miho; Mogi, Kazutaka; Hasegawa, Toshikazu; Kikusui, Takefumi

2014-01-01

312

Training shelter volunteers to teach dog compliance.  

PubMed

This study examined the degree to which training procedures influenced the integrity of behaviorally based dog training implemented by volunteers of an animal shelter. Volunteers were taught to implement discrete-trial obedience training to teach 2 skills (sit and wait) to dogs. Procedural integrity during the baseline and written instructions conditions was low across all participants. Although performance increased with use of a video model, integrity did not reach criterion levels until performance feedback and modeling were provided. Moreover, the integrity of the discrete-trial training procedure was significantly and positively correlated with dog compliance to instructions for all dyads. Correct implementation and compliance were observed when participants were paired with a novel dog and trainer, respectively, although generalization of procedural integrity from the discrete-trial sit procedure to the discrete-trial wait procedure was not observed. Shelter consumers rated the behavior change in dogs and trainers as socially significant. Implications of these findings and future directions for research are discussed. PMID:24924218

Howard, Veronica J; DiGennaro Reed, Florence D

2014-01-01

313

50 CFR 36.36 - Sled dogs and household pets.  

Code of Federal Regulations, 2011 CFR

...2011-10-01 false Sled dogs and household pets. 36.36 Section 36.36 Wildlife...Uses § 36.36 Sled dogs and household pets. The general trespass provisions of 50 CFR 26.21 shall not apply to household pets and sled, work, or pack dogs...

2011-10-01

314

50 CFR 36.36 - Sled dogs and household pets.  

Code of Federal Regulations, 2012 CFR

...2012-10-01 false Sled dogs and household pets. 36.36 Section 36.36 Wildlife...Uses § 36.36 Sled dogs and household pets. The general trespass provisions of 50 CFR 26.21 shall not apply to household pets and sled, work, or pack dogs...

2012-10-01

315

50 CFR 36.36 - Sled dogs and household pets.  

Code of Federal Regulations, 2010 CFR

...2010-10-01 false Sled dogs and household pets. 36.36 Section 36.36 Wildlife...Uses § 36.36 Sled dogs and household pets. The general trespass provisions of 50 CFR 26.21 shall not apply to household pets and sled, work, or pack dogs...

2010-10-01

316

50 CFR 36.36 - Sled dogs and household pets.  

Code of Federal Regulations, 2013 CFR

...2013-10-01 false Sled dogs and household pets. 36.36 Section 36.36 Wildlife...Uses § 36.36 Sled dogs and household pets. The general trespass provisions of 50 CFR 26.21 shall not apply to household pets and sled, work, or pack dogs...

2013-10-01

317

50 CFR 36.36 - Sled dogs and household pets.  

Code of Federal Regulations, 2014 CFR

...2014-10-01 false Sled dogs and household pets. 36.36 Section 36.36 Wildlife...Uses § 36.36 Sled dogs and household pets. The general trespass provisions of 50 CFR 26.21 shall not apply to household pets and sled, work, or pack dogs...

2014-10-01

318

Spontaneous and Age-Related Testicular Findings in Beagle Dogs  

Microsoft Academic Search

This study was conducted to characterize spontaneous testicular and epididymal microscopic findings in eighty control beagle dogs from toxicity studies. Hypospermatogenesis, characterized by randomly scattered missing spermatids and\\/or spermatocytes within seminiferous tubules, was observed in 75% of dogs six to seven months of age and declined to fewer than 10% in dogs over eleven months of age. Atrophy\\/hypoplasia of seminiferous

MICHAEL J. GOEDKEN; R OY L. KERLIN; DANIEL MORTON

2008-01-01

319

Barking in domestic dogs: context specificity and individual identification  

E-print Network

Barking in domestic dogs: context specificity and individual identification SOPHIA YIN* & BRENDA acceptance 24 July 2003; MS. number: A9405R2) In this study we sought to determine whether dog barks could be divided into subtypes based on context. We recorded barking from 10 adult dogs, Canis familiaris, of six

McCowan, Brenda

320

The conservation role of captive African wild dogs (Lycaon pictus)  

E-print Network

The conservation role of captive African wild dogs (Lycaon pictus) M.A.J. Frantzen, J.W.H. Ferguson the long-term survival of the African wild dog (Lycaon pictus). To aid this, a studbook was assembled the largest existing regional population of captive African wild dogs. These populations were investigated

Altwegg, Res

321

Thrombocytosis associated with a myeloproliferative disorder in a dog  

SciTech Connect

A dog with a myeloproliferative disorder and thrombocytosis had clinical signs that were consistent with a diagnosis of essential thrombocythemia. The dog was treated with aspirin, radioactive phosphorus, and melphalan. Eighteen months after referral, the disorder progressed to chronic granulocytic leukemia, and treatment was switched to hydroxyurea. Fourteen months later, the dog was euthanatized because of uncontrollable atrial fibrillation.

Degen, M.A.; Feldman, B.F.; Turrel, J.M.; Goding, B.; Kitchell, B.; Mandell, C.P. (Univ. of California, Davis (USA))

1989-05-15

322

MRI of surgically created pulmonary artery narrowing in the dog  

Microsoft Academic Search

Narrowing of the pulmonary arteries was created surgically in twelve dogs. In six of the dogs the narrowing was central (main pulmonary artery), and in the remaining six the narrowing was located peripherally at the hilar level of the right pulmonary artery beyond the pericardial reflection. MRI and angiography were performed in all dogs. MRI clearly delineated the site of

R. J. Hernandez; A. P. Rocchini; E. L. Bove; T. L. Chenevert; B. Gubin

1989-01-01

323

Polioencephalomyelopathy in a mixed breed dog resembling Leigh's disease.  

PubMed

A 14-month-old mixed-breed dog was presented with acute onset of exercise intolerance that quickly progressed to quadriparesis. Gross and microscopic autopsy findings indicated a type of degenerative polioencephalomyelopathy resembling subacute necrotizing encephalomyelopathy in dogs or Leigh's disease in humans. This syndrome has previously been reported only in purebred dogs. PMID:25565716

Chai, Orit; Milgram, Joshua; Shamir, Merav H; Brenner, Ori

2015-01-01

324

Dog population management for the control of human echinococcosis.  

PubMed

Cystic and alveolar hydatid disease of humans caused by infection with Echinococcus granulosus or Echinococcus multilocularis are significant zoonoses in developing countries. For human infections, the main definitive host is the dog, and reduction in the population of unwanted dogs, together with anthelmintic treatment of wanted dogs, are recommended control procedures for these zoonoses. Both owned and unowned dogs have been shown to be a major source of Echinococcus spp. infection in developing countries. Unowned dogs are the most challenging category in dog population management for the control of major zoonotic diseases. Unowned dogs are those dogs that do not have an owner, and those dogs whose owner cannot readily be identified. Control of numbers of unowned dogs can be done in various ways if funds are available. Fertility control and humane euthanasia are likely to be the most effective procedures in developing countries. Fertility control requires significant funding, and where resources are scarce humane euthanasia may be the most effective option. Both procedures are ongoing events, with no predictable end point. This paper examines the sociology and technology for the population management of owned and unowned dogs, specifically for the reduction of human hydatid disease. Examples are given for developing and developed countries. Although a "One Health" approach is desirable, the technology for hydatid control is different from that for rabies, and FAO Animal Welfare recommendations for dog population management should be adjusted accordingly. PMID:25046696

Kachani, Malika; Heath, David

2014-11-01

325

Prairie Dog Overpopulation: Value Judgement or Ecological Reality?  

Microsoft Academic Search

The subject of prairie dog (Cynomys ludovicianus) overpopulation is complex, and judgements of overpopulation may not be based on prairie dog population size or density. Caughley's (1981) model of animal overpopulation is applied here to prairie dogs to clarify the basis for a judgement of overpopulation in each of several cases. There are ecological components to all such cases, but

Kirsten Krueger

1987-01-01

326

Concurrent diabetes mellitus and lymphoma in a German shepherd dog  

Microsoft Academic Search

Summary Concurrent disorders with diabetes mellitus is one of the most challenging subject. Our knowledge of the most common concurrent disorders in diabetic dogs may be useful in diagnosis of these disorders and better treatment of diabetic dogs. In this study diabetes mellitus was diagnosed in a 7-year-old male German shepherd dog, based on clinical and laboratory findings. Following the

Selk Ghaffari; O. Dezfoulian; M. Selk Ghaffari

327

Comparative aspects of diabetes mellitus in dogs and cats  

Microsoft Academic Search

Diabetes mellitus is a common disease in cats and dogs. Its incidence is increasing, possibly due to an increase in obesity in both species. Different types of diabetes have been identified in pet animals. The classification of diabetic dogs and cats is modeled after the human classification but especially in the diabetic dogs, many aspects are different. The diabetic cat,

M Hoenig

2002-01-01

328

How Dogs Know when Communication Is Intended for Them  

ERIC Educational Resources Information Center

Domestic dogs comprehend human gestural communication in a way that other animal species do not. But little is known about the specific cues they use to determine when human communication is intended for them. In a series of four studies, we confronted both adult dogs and young dog puppies with object choice tasks in which a human indicated one of…

Kaminski, Juliane; Schulz, Linda; Tomasello, Michael

2012-01-01

329

Myocarditis and cardiomyopathy in the dog and cat  

Microsoft Academic Search

Summary Myocarditis and cardiomyopathy were diagnosed in 36 dogs from 11 litters, and myoendocarditis and restrictive cardiomyopathy were diagnosed in 51 cats. Most of the dogs and cats died unexpectedly. Spontaneous parvoviral infection in the dogs caused acute (myocytolysis with presence of intranuclear inclusion bodies in the myocytes), subacute (inflammatory reaction and myocytolysis), and chronic (fibrosis and myocytolysis) myocarditis, which

Si-Kwang Liu

1985-01-01

330

Prospective medical evaluation of 7 dogs presented with fly biting  

PubMed Central

Fly biting describes a syndrome in which dogs appear to be watching something and then snapping at it. Medical work-up of fly biting in dogs has never been reported. The aims of this case series were to characterize fly biting and perform a complete medical evaluation of dogs displaying fly biting. PMID:23729825

Frank, Diane; Bélanger, Marie C.; Bécuwe-Bonnet, Véronique; Parent, Joane

2012-01-01

331

Inheritance of coat colour in the field spaniel dog  

E-print Network

Note Inheritance of coat colour in the field spaniel dog R Robinson St Stephens Nursery, Stephens known as roan. dog genetics / coat colour / field spaniel / breed Résumé - Hérédité de la couleur du for the heredity of coat colour in the dog (Little, 1957; Robinson, 1990), it has become apparent as work

Paris-Sud XI, Université de

332

Original article Cytokeratin immunostaining in normal dog major  

E-print Network

Original article Cytokeratin immunostaining in normal dog major and minor salivary glands Mahmut for cytokeratins 5, 6, 8, 17 and 19 of dog submandibular, sublingual, parotid, palatine, tongue and zygomatic sali. Mucous cells were not stained in any of the glands. © Inra/Elsevier, Paris salivary gland / dog

Paris-Sud XI, Université de

333

36 CFR 262.11 - Impounding of dogs.  

Code of Federal Regulations, 2014 CFR

...2014-07-01 2014-07-01 false Impounding of dogs. 262.11 Section 262.11 Parks, Forests, and...Impoundments and Removals § 262.11 Impounding of dogs. Any dog found running at large in a part of the National...

2014-07-01

334

Soil change induced by prairie dogs across three ecological sites  

Technology Transfer Automated Retrieval System (TEKTRAN)

Prairie dogs (Cynomys spp.) can influence vegetation dynamics and landscape hydrology by altering soil properties, yet few studies have evaluated soil responses to prairie dog activities across a range of soil types. This study was conducted to quantify prairie dog effects on soil properties within...

335

46 CFR 386.19 - Dogs and other animals.  

Code of Federal Regulations, 2011 CFR

...2011-10-01 2011-10-01 false Dogs and other animals. 386.19 Section...STATES MERCHANT MARINE ACADEMY § 386.19 Dogs and other animals. Persons are prohibited from bringing dogs and other animals on to the Academy...

2011-10-01

336

36 CFR 262.11 - Impounding of dogs.  

Code of Federal Regulations, 2012 CFR

...2012-07-01 2012-07-01 false Impounding of dogs. 262.11 Section 262.11 Parks, Forests, and...Impoundments and Removals § 262.11 Impounding of dogs. Any dog found running at large in a part of the National...

2012-07-01

337

46 CFR 386.19 - Dogs and other animals.  

Code of Federal Regulations, 2010 CFR

...2010-10-01 2010-10-01 false Dogs and other animals. 386.19 Section...STATES MERCHANT MARINE ACADEMY § 386.19 Dogs and other animals. Persons are prohibited from bringing dogs and other animals on to the Academy...

2010-10-01

338

Port-access mitral valve replacement in dogs  

Microsoft Academic Search

Objective: The objective was to assess mitral valve replacement in a minimally invasive fashion by means of port-access technology. Methods: Fifteen dogs, 28 ± 3 kg (mean ± standard deviation), were studied with the port-access mitral valve replacement system (Heartport, Inc., Redwood City, Calif.). Eleven dogs underwent acute studies and were sacrificed immediately after the procedure. Four dogs were allowed

Mario F. Pompili; John H. Stevens; Thoms A. Burdon; Lawrence C. Siegel; William S. Peters; Greg H. Ribakove; Bruce A. Reitz

1996-01-01

339

46 CFR 386.19 - Dogs and other animals.  

Code of Federal Regulations, 2012 CFR

...2012-10-01 2012-10-01 false Dogs and other animals. 386.19 Section...STATES MERCHANT MARINE ACADEMY § 386.19 Dogs and other animals. Persons are prohibited from bringing dogs and other animals on to the Academy...

2012-10-01

340

36 CFR 262.11 - Impounding of dogs.  

Code of Federal Regulations, 2013 CFR

...2013-07-01 2013-07-01 false Impounding of dogs. 262.11 Section 262.11 Parks, Forests, and...Impoundments and Removals § 262.11 Impounding of dogs. Any dog found running at large in a part of the National...

2013-07-01

341

Genetic Evidence for an East Asian Origin of Domestic Dogs  

Microsoft Academic Search

The origin of the domestic dog from wolves has been established, but the number of founding events, as well as where and when these occurred, is not known. To address these questions, we examined the mitochondrial DNA (mtDNA) sequence variation among 654 domestic dogs representing all major dog populations worldwide. Although our data indicate several maternal origins from wolf, >95%

Peter Savolainen; Ya-ping Zhang; Jing Luo; Joakim Lundeberg; Thomas Leitner

2002-01-01

342

46 CFR 386.19 - Dogs and other animals.  

Code of Federal Regulations, 2013 CFR

...2013-10-01 2013-10-01 false Dogs and other animals. 386.19 Section...STATES MERCHANT MARINE ACADEMY § 386.19 Dogs and other animals. Persons are prohibited from bringing dogs and other animals on to the Academy...

2013-10-01

343

36 CFR 262.11 - Impounding of dogs.  

Code of Federal Regulations, 2010 CFR

...2010-07-01 2010-07-01 false Impounding of dogs. 262.11 Section 262.11 Parks, Forests, and...Impoundments and Removals § 262.11 Impounding of dogs. Any dog found running at large in a part of the National...

2010-07-01

344

36 CFR 262.11 - Impounding of dogs.  

Code of Federal Regulations, 2011 CFR

...2011-07-01 2011-07-01 false Impounding of dogs. 262.11 Section 262.11 Parks, Forests, and...Impoundments and Removals § 262.11 Impounding of dogs. Any dog found running at large in a part of the National...

2011-07-01

345

46 CFR 386.19 - Dogs and other animals.  

Code of Federal Regulations, 2014 CFR

...2014-10-01 2014-10-01 false Dogs and other animals. 386.19 Section...STATES MERCHANT MARINE ACADEMY § 386.19 Dogs and other animals. Persons are prohibited from bringing dogs and other animals on to the Academy...

2014-10-01

346

50 CFR 28.43 - Destruction of dogs and cats.  

Code of Federal Regulations, 2010 CFR

...2010-10-01 2010-10-01 false Destruction of dogs and cats. 28.43 Section 28.43 Wildlife and Fisheries...Impoundment Procedures § 28.43 Destruction of dogs and cats. Dogs and cats running at large on a national wildlife refuge and...

2010-10-01

347

50 CFR 28.43 - Destruction of dogs and cats.  

Code of Federal Regulations, 2012 CFR

...2012-10-01 2012-10-01 false Destruction of dogs and cats. 28.43 Section 28.43 Wildlife and Fisheries...Impoundment Procedures § 28.43 Destruction of dogs and cats. Dogs and cats running at large on a national wildlife refuge and...

2012-10-01

348

50 CFR 28.43 - Destruction of dogs and cats.  

Code of Federal Regulations, 2011 CFR

...2011-10-01 2011-10-01 false Destruction of dogs and cats. 28.43 Section 28.43 Wildlife and Fisheries...Impoundment Procedures § 28.43 Destruction of dogs and cats. Dogs and cats running at large on a national wildlife refuge and...

2011-10-01

349

50 CFR 28.43 - Destruction of dogs and cats.  

Code of Federal Regulations, 2014 CFR

...2014-10-01 2014-10-01 false Destruction of dogs and cats. 28.43 Section 28.43 Wildlife and Fisheries...Impoundment Procedures § 28.43 Destruction of dogs and cats. Dogs and cats running at large on a national wildlife refuge and...

2014-10-01

350

50 CFR 28.43 - Destruction of dogs and cats.  

Code of Federal Regulations, 2013 CFR

...2013-10-01 2013-10-01 false Destruction of dogs and cats. 28.43 Section 28.43 Wildlife and Fisheries...Impoundment Procedures § 28.43 Destruction of dogs and cats. Dogs and cats running at large on a national wildlife refuge and...

2013-10-01

351

Ticks parasitizing dogs in northwestern Georgia.  

PubMed

From January 1998 through September 1999, 324 dogs in three northwestern Georgia counties were examined for ticks. Six species of ticks were recovered. The three most commonly collected ticks were the American dog tick, Dermacentor variabilis (Say) (310 male male, 352 female female; prevalence, 97%; mean intensity 2.1); the brown dog tick, Rhipicephalus sanguineus (Latreille) (118 male male, 119 female female, 38 nymphs; prevalence, 22%; mean intensity, 3.8); and the lone star tick, Amblyomma americanum (L.) (8 male male 26 female female, 2 nymphs; prevalence, 5%; mean intensity, 2.4). Other ticks recovered were Ixodes cookei Packard (3 female female); the Gulf Coast tick, Amblyomma maculatum Koch (2 female female); and the blacklegged tick, Ixodes scapularis Say (1 female). Another adult female specimen of I scapularis was recovered from a cat, further reinforcing that this medically important tick is present in northwestern Georgia. PMID:11931241

Goldberg, M; Recha, Y; Durden, L A

2002-01-01

352

Total hip replacement in a dog.  

PubMed

An intact male German shepherd dog (4 y, body wt. 35.5 kg) was referred to the Animal Medical Center, Chonbuk National University with severe lameness, pain and gait abnormality on the right hind limb. Survey radiographs of the pelvis revealed dysplasia of the right coxofemoral joint with subluxation. The dog was surgically treated performing total hip replacement (THR) using Modular Biolox Canine Modular THR System. The dog began to bear weight and slowly returned to a normal exercise pattern 2 months after surgery. THR resulted in satisfactory clinical functions with 6 months follow up and no complications were observed. Canine modular THR could be a successful modality for the management of disabling conditions of the coxofemoral joint. PMID:15933440

Kim, Nam-Soo; Alam, Md Rafiqul; Jeong, In-Seong; Lee, Jong-Il; Choi, In-Hyuk

2005-06-01

353

Allogeneic Astrocytoma In Immune Competent Dogs  

PubMed Central

Abstract We have induced in canines long-term immune tolerance to an allogeneic cell line derived from a spontaneous canine astrocytoma. Allogeneic astrocytoma cells were implanted endoscopically into the subcutaneous space of fetal dogs before the onset of immune competency (<40th gestational day). At adulthood, dogs rendered tolerant successfully serve as recipients of intracranial transplants of their growing allogeneic, subcutaneous tumor. Transplanted dogs subsequently develop a solid brain tumor with histological features similar to the original astrocytoma. This model may allow rapid development and evaluation of new therapies for brain tumors, as well as afford tumor biology studies that are untenable in smaller, immune incompetent, or inbred animals harboring less representative tumors. PMID:10933043

Berens, Michael E; Giese, Alf; Shapiro, Joan R; Coons, Stephen W

1999-01-01

354

Country Dog Gentlemen Travel to Extraordinary Worlds  

NSDL National Science Digital Library

This interactive gallery designed for children of all ages was produced by the Education Department of the San Francisco Museum of Modern Art (SFMOMA). In the interactive, the "Country Dog Gentlemen", characters first depicted in a 1972 painting of the same name by the late Bay Area artist Roy De Forest (1930-2007), lead explorations of paintings and sculpture by Frieda Kahlo, Jackson Pollack, and Sargent Johnson. Students can watch the dogs sniffing out the story of each work, or create their own art, in various activities inspired by the originals. For example, the activity based on Kahlo's portrait, Frieda and Diego Rivera, 1931, is to swap the clothing and pets in Kahlo's work. The questions the Country Dog Gentlemen ask about Sargent Johnson's sculpture Forever Free, 1933, could make a good Black History Month lesson.

355

Naturally occurring tularemia in a dog.  

PubMed

A 4-year-old spayed female Irish Setter was examined because of acute onset of lethargy, anorexia, and weakness. The dog had eaten an adult rabbit 36 hours earlier. Tularemia was suspected because of the rabbit exposure; however, other common diseases characterized by fever, malaise, and lymphadenopathy of acute onset were also considered (ie, ehrlichiosis and Rocky Mountain spotted fever). The dog was treated with doxycycline (5 mg/kg [2.3 mg/lb], PO, q 24 h) for 14 days as well as supportive treatment with a balanced electrolyte solution (lactated Ringer's solution [200 mL, SC]). The diagnosis was first established by results of bacteriologic cultures of fine-needle aspirates obtained from lymph nodes and confirmed by results of ELISA and a polymerase chain reaction assay Successful and timely antemortem diagnosis of tularemia in dogs can be accomplished through lymph node aspiration and bacteriologic culture. PMID:15344361

Meinkoth, Katrina R; Morton, Rebecca J; Meinkoth, James H

2004-08-15

356

Sarcocystis neurona encephalitis in a dog.  

PubMed

A 1.5-year-old male Feist dog was presented to a veterinarian for reluctance to stand on the hind legs. Treatment included dexamethasone and resulted in a favorable initial response, but posterior paresis returned and progressed to recumbency, hyperesthesia, and attempts to bite the owner. The dog was euthanized. The brain was negative for rabies by fluorescent antibody analysis. Multiple foci of encephalitis were found in the cerebrum and particularly in the cerebellum. Protozoa morphologically consistent with Sarcocystis sp. were identified at sites of intense inflammation and malacia. Additionally, multiple schizonts were identified in areas without inflammation. Immunohistochemistry using both polyclonal and monoclonal antibodies specific for Sarcocystis neurona was strongly positive. No reaction to polyclonal antisera for Toxoplasma gondii or Neospora caninum was found. Polymerase chain reaction confirmed that the protozoa were S. neurona. Additional aberrant hosts for S. neurona other than horses have been identified, but S. neurona encephalitis has not been documented previously in the dog. PMID:18039914

Cooley, A J; Barr, B; Rejmanek, D

2007-11-01

357

Biological effects of {sup 137}CsCl injected in beagle dogs of different dogs  

SciTech Connect

The toxicity of {sup 137}Cs in the beagle dog was investigated at the Inhalation Toxicology Research Institute (ITRI) and Argonne National Laboratory (ANL) as part of programs to evaluate the biological effects of both radionuclides in atomic bomb fallout and internally deposited fission-product radionuclides. In the ITRI study, young adult dogs were exposed once by intravenous injection to a range of {sup 137}Cs concentrations; the results have recently been published. The purpose of the present report is to summarize the ANL study and to compare the results of the two studies. At ANL, 63 dogs in three age groups (15 juveniles, 142-151 days old; 38 young adults, 388-427 days old; and 10 middle-aged dogs, 1387-2060 days old) were given {sup 137}Cs intravenously at levels (61-162f MBq/kg) near those expected to be lethal within 30 days after injection. There were 17 control dogs from the same colony. Twenty-three of the dogs injected with {sup 137}Cs, including all middle-aged dogs, died within 52 days after injection due to hematopoietic cell damage resulting in severe pancytopenia that led to fatal hemorrhage and/or septicemia. The other significant early effect was damage to the germinal epithelium of the seminiferous tubules. The design of the ANL study revealed an age- and gender-related differential radiosensitivity for early effects. The middle-aged dogs died significantly earlier due to complications of hematological dyscrasia compared to the juvenile and young adult dogs, and the middle-aged females died significantly earlier than the middle-aged males. The most significant non-neoplastic late effects in the {sup 137}Cs-injected dogs from ANL and ITRI were atrophy of the germinal epithelium of seminiferous tubules with azoospermia, and a significant dose-dependent decrease in survival. The survival of the ANL dogs was decreased more than that of the ITRI dogs at similar radiation doses from {sup 137}Cs. 19 refs., 6 figs., 4 tabs.

Nikula, K.J.; Boecker, B.B.; Griffith, W.C. [Inhalation Toxicology Research Institute, Albuquerque, NM (United States)] [and others

1996-11-01

358

Genome sequencing highlights the dynamic early history of dogs.  

PubMed

To identify genetic changes underlying dog domestication and reconstruct their early evolutionary history, we generated high-quality genome sequences from three gray wolves, one from each of the three putative centers of dog domestication, two basal dog lineages (Basenji and Dingo) and a golden jackal as an outgroup. Analysis of these sequences supports a demographic model in which dogs and wolves diverged through a dynamic process involving population bottlenecks in both lineages and post-divergence gene flow. In dogs, the domestication bottleneck involved at least a 16-fold reduction in population size, a much more severe bottleneck than estimated previously. A sharp bottleneck in wolves occurred soon after their divergence from dogs, implying that the pool of diversity from which dogs arose was substantially larger than represented by modern wolf populations. We narrow the plausible range for the date of initial dog domestication to an interval spanning 11-16 thousand years ago, predating the rise of agriculture. In light of this finding, we expand upon previous work regarding the increase in copy number of the amylase gene (AMY2B) in dogs, which is believed to have aided digestion of starch in agricultural refuse. We find standing variation for amylase copy number variation in wolves and little or no copy number increase in the Dingo and Husky lineages. In conjunction with the estimated timing of dog origins, these results provide additional support to archaeological finds, suggesting the earliest dogs arose alongside hunter-gathers rather than agriculturists. Regarding the geographic origin of dogs, we find that, surprisingly, none of the extant wolf lineages from putative domestication centers is more closely related to dogs, and, instead, the sampled wolves form a sister monophyletic clade. This result, in combination with dog-wolf admixture during the process of domestication, suggests that a re-evaluation of past hypotheses regarding dog origins is necessary. PMID:24453982

Freedman, Adam H; Gronau, Ilan; Schweizer, Rena M; Ortega-Del Vecchyo, Diego; Han, Eunjung; Silva, Pedro M; Galaverni, Marco; Fan, Zhenxin; Marx, Peter; Lorente-Galdos, Belen; Beale, Holly; Ramirez, Oscar; Hormozdiari, Farhad; Alkan, Can; Vilŕ, Carles; Squire, Kevin; Geffen, Eli; Kusak, Josip; Boyko, Adam R; Parker, Heidi G; Lee, Clarence; Tadigotla, Vasisht; Siepel, Adam; Bustamante, Carlos D; Harkins, Timothy T; Nelson, Stanley F; Ostrander, Elaine A; Marques-Bonet, Tomas; Wayne, Robert K; Novembre, John

2014-01-01

359

Pulmonary Echinococcus multilocularis metastasis in a dog.  

PubMed

A young adult Labrador retriever dog was presented for surgical debulking of hepatic alveolar echinococcosis. Computed tomography detected hepatomegaly with multiple large cavitary masses with extension of tissue from a lesion wall into the caudal vena cava and numerous nodules in all lung lobes. Following euthanasia, histology confirmed parasitic vesicles with granulomatous reaction in all lesions, and polymerase chain reaction (PCR) established the causative agent to be Echinococcus multilocularis. This report is the first to present imaging features of pulmonary E. multilocularis granulomata in a dog. PMID:25750447

Gendron, Karine; Goepfert, Christine; Linon, Elisa; Posthaus, Horst; Frey, Caroline F

2015-03-01

360

Salmonella organisms in mature, healthy dogs  

E-print Network

twenty per 3S csnC o Several instances of concurrent infacCion in dogs and ~ living in tbs intimate anviromssnt of a household have bosn proven. Galton at ~al 31 16 made 1Lmitsd studies of tba human contacts of known infecCad anbsals an4 obtained...BEA AGAR Total Nueber 24 4S 7 14 Seeaiead iiggp Qgg ~OE ~D ~HClss 244 2 0 3 0 Persco loss 19 3 0 &1k@1&geese 14 Sebaoee lla 18 0 0 0 1S 16 1 ~ 5 ~ 10, 16. Adler~ H E, : tncidsaos of Saheonslla in Apparently Healthy Dogs. Je AeVaHeko ~ Ll...

Jungerman, Paul F

1959-01-01

361

Chronic kidney disease in dogs and cats.  

PubMed

Chronic kidney disease (CKD) occurs commonly in older dogs and cats. Advances in diagnostics, staging, and treatment are associated with increased quality and quantity of life. Dietary modification has been shown to increase survival and quality of life and involves more than protein restriction as diets modified for use with CKD are lower in phosphorous and sodium, potassium and B-vitamin replete, and alkalinizing, and they contain n3-fatty acids. Additionally, recognition and management of CKD-associated diseases such as systemic arterial hypertension, proteinuria, and anemia benefit patients. This article summarizes staging and management of CKD in dogs and cats. PMID:22720808

Bartges, Joseph W

2012-07-01

362

An Old Dog and New Tricks  

NASA Technical Reports Server (NTRS)

As I approach my 55th birthday, the old adage 'you can't teach an old dog new tricks' keeps coming to mind. I'm not sure why, because I don't feel old and I'm still interested in taking on new challenges and learning new tricks. However, as I mentor new project managers, I am also aware that others may consider me an old dog unable to learn new tricks. To the contrary, the people I mentor continue to teach me new tricks and challenge my assumptions about project management.

Cameron, W. Scott

2003-01-01

363

Guidelines for vaccination of dogs and cats in Korea  

PubMed Central

This guideline contains the recommended vaccination schedules of dogs and cats from World Small Animal Veterinary Association (WSAVA) and American Animal Hospital Association (AAHA). In 2010, WSAVA published guidelines for the vaccination of dogs and cats. And, in 2011, AAHA also published guidelines for vaccination of dogs. In Korea, there is no published guideline for vaccination of dogs and cats yet. Therefore, the plane of vaccination also reports the present situation of vaccination schedule of dogs and cats in Korean animal hospitals. PMID:25003099

2014-01-01

364

The relationship of callosal anatomy to paw preference in dogs.  

PubMed

Previous studies have described the paw preference and asymmetry in dog brains, based on experimental studies. The purpose of the present study is to investigate a possible association between callosal anatomy and paw preference in dogs. The midsagittal area of the dog corpus callosum was measured in its entirety and in six subdivisions in a sample of 21 brains obtained from 9 male and 12 female mongrel dogs which had paw preference testing. The present study showed significant paw differences in dog corpus callosum. A posterior segment of the callosum, the isthmus, was significantly larger in the right pawedness than the left. PMID:10694910

Aydinlioglu, A A; Arslanirli, K A; Riza Erdogan, M A; Ragbetli, M C; Kele?, P; Diyarbakirli, S

2000-04-01

365

Trypanosoma evansi infection in dogs: seasonal prevalence and chemotherapy.  

PubMed

A 1-year survey was undertaken to determine the incidence of Trypanosoma evansi in dogs at Ludhiana, India. Of 64 dogs examined by wet film, thin smear, thick smear and mouse inoculation, three (4.68%) were found to be positive for T. evansi. All the positive animals were detected during the rainy and post-rainy seasons. The treatment of three infected dogs with a combination of quinpyramine sulphate and chloride (3:2 w/w) resulted in complete recovery of two dogs; another dog died on the day therapy was initiated. PMID:8291188

Singh, B; Kalra, I S; Gupta, M P; Nauriyal, D C

1993-10-01

366

Dipylidium caninum infection in dogs infested with fleas.  

PubMed

The present study pertains to the Dipylidium caninum infection in dogs infested with fleas. Twenty dogs were presented to the Divison of Surgery, SKUAST-K for different surgical procedures. Majority of the dogs had a history of pruritus, loss of weight as well as rubbing their perineal region against the wall. On external examination dogs were found infested with Ctenocephalides canis. When dogs were anesthetized, motile segments were seen coming out of their anus, which were then identified as mature segments of D. caninum. PMID:25698864

Wani, Z A; Allaie, I M; Shah, B M; Raies, A; Athar, H; Junaid, S

2015-03-01

367

Even Lesbian Youths or Those Presumed to Be Lesbians Are Protected by the Constitution of Uganda--But to a Limited Extent: Rules the High Court  

ERIC Educational Resources Information Center

The Ugandan Penal Code criminalizes same-sex relationships. The author analyzes the Ugandan High Court decision where the judge relied on the Constitution and international human rights instruments to hold that law enforcement officers must respect the rights to privacy and human dignity even of those people presumed to be in same-sex…

Mujuzi, Jamil Ddamulira

2009-01-01

368

"Like Owner, Like Dog": Correlation between the Owner's Attachment Profile and the Owner-Dog Bond  

PubMed Central

During recent years, several studies have revealed that human-dog relationships are based on a well-established and complex bond. There is now evidence suggesting that the dog–human affectional bond can be characterized as an “attachment”. The present study investigated possible association between the owners' attachment profile assessed throughout a new semi-projective test (the 9 Attachment Profile) and the owner-dog attachment bond evaluated using a modified version of those used in studying human infants: Ainsworth's “strange situation”. The findings represented the first evidence for the presence of a correlation between the owners' attachment profile and the owner-dog attachment bond throughout procedure and behavioural analyses involving controlled observations. PMID:24205235

Siniscalchi, Marcello; Stipo, Carlo; Quaranta, Angelo

2013-01-01

369

[Dog population and dog breeds in Switzerland from 1955 to 2008].  

PubMed

Aim of this study is to present a survey of the dog population and breed distribution in Switzerland from 1955 to 2008 as basis to realize a population based canine cancer register for Switzerland. The number of dogs rose from 309'000 in 1955 to approximately 500'000 in 2008 correlating with a parallel increase of human population. The ratio of dogs per 100 inhabitants remains stable. This ratio is lower in German speaking compared to French or Italian speaking Cantons. The variety and popularity of breeds changed from 1955 to 2008, "winners" are Labrador and Golden Retrievers, Yorkshire and Jack Russel Terriers. Less popular breeds over the years are German Sheherd dogs and Poodles. PMID:23531943

Pospischil, Andreas; Hässig, M; Vogel, R; Salvini, M M; Fabrikant, S; Axhausen, K; Schenker, S N; Erni, D; Guscetti, F

2013-04-01

370

Prevalence of Toxocara canis infection in household dogs.  

PubMed

The prevalence of Toxocara canis infection in household dogs was estimated by examining feces from 1,743 dogs aged between 1 month and 15 years old. Fecal samples from 75 (4.3%) of the 1,743 dogs were positive for the eggs of T. canis. The dogs with positive fecal samples ranged from 1 month to 5 years old in age. The infection rate in dogs aged 1 to 6 months old was significantly (p < 0.01) higher than that in dogs aged 7 months to 2 years old or over 3 years old. Indoor dogs aged 1 to 6 months old showed a significantly (p < 0.01) lower prevalence than outdoor dogs of the same age group. With respect to the place of origin of the dogs, those originating from individual households (5.7%) showed (p < 0.05) a higher prevalence as compared to the animals purchased from pet shops/breeding kennels (3.5%). Considering the origin and the living conditions, the prevalence in indoor dogs originating from individual households was significantly (p < 0.05) higher than that in indoor dogs purchased from pet shops/breeding kennels. PMID:15103902

Itoh, Naoyuki; Muraoka, Noboru; Aoki, Mikiko; Itagaki, Tadashi

2004-02-01

371

Dogs can discriminate human smiling faces from blank expressions.  

PubMed

Dogs have a unique ability to understand visual cues from humans. We investigated whether dogs can discriminate between human facial expressions. Photographs of human faces were used to test nine pet dogs in two-choice discrimination tasks. The training phases involved each dog learning to discriminate between a set of photographs of their owner's smiling and blank face. Of the nine dogs, five fulfilled these criteria and were selected for test sessions. In the test phase, 10 sets of photographs of the owner's smiling and blank face, which had previously not been seen by the dog, were presented. The dogs selected the owner's smiling face significantly more often than expected by chance. In subsequent tests, 10 sets of smiling and blank face photographs of 20 persons unfamiliar to the dogs were presented (10 males and 10 females). There was no statistical difference between the accuracy in the case of the owners and that in the case of unfamiliar persons with the same gender as the owner. However, the accuracy was significantly lower in the case of unfamiliar persons of the opposite gender to that of the owner, than with the owners themselves. These results suggest that dogs can learn to discriminate human smiling faces from blank faces by looking at photographs. Although it remains unclear whether dogs have human-like systems for visual processing of human facial expressions, the ability to learn to discriminate human facial expressions may have helped dogs adapt to human society. PMID:21359654

Nagasawa, Miho; Murai, Kensuke; Mogi, Kazutaka; Kikusui, Takefumi

2011-07-01

372

Ticks and haemoparasites of dogs from Praia, Cape Verde.  

PubMed

In February 2008 an epidemiological field study on arthropod-borne infections in dogs was carried out in Praia, the capital city of Cape Verde. For this purpose 130 dogs were included in the study. Of these, 94.6% were infested with ticks. Altogether, 1293 ticks of the genus Rhipicephalus (in all evaluated cases R. sanguineus) were collected. Examination for haemotropic parasites was performed via polymerase chain reaction (PCR). Lymph node fine-needle aspirates were screened by PCR for Leishmania infantum infections in 20 dogs with enlarged lymph nodes. Our investigation revealed two species of protozoa (Babesia canis vogeli and Hepatozoon canis) and two species of rickettsiae (Anaplasma platys and Ehrlichia canis). In 101 dogs (77.7%) DNA of one or more pathogens was detected. The PCR examination for H. canis was positive in 83 dogs (63.8%), for E. canis in 34 dogs (26.2%), for A. platys in 10 dogs (7.7%) and for B. canis in five dogs (3.8%), whereas neither B. gibsoni nor L. infantum DNA could be detected. Of the infected dogs, 71.3% had a monoinfection, 27.7% had infections with two pathogens and 1.0% with three pathogens. B. canis, H. canis, E. canis, A. platys and their vector tick R. sanguineus are endemic to Cape Verde and can be present in dogs in high prevalences. These results outline the risk of importing tropical canine diseases when Capeverdian stray dogs are taken to Europe. PMID:19729247

Götsch, S; Leschnik, M; Duscher, G; Burgstaller, J P; Wille-Piazzai, W; Joachim, A

2009-12-01

373

Extracorporeal shockwave therapy for shoulder lameness in dogs.  

PubMed

The purpose of this article was to describe the outcome of dogs with instability, calcifying, and inflammatory conditions of the shoulder treated with extracorporeal shockwave therapy (ESWT). Medical records for 15 dogs with lameness attributable to the shoulder that failed previous conservative management were retrospectively reviewed. ESWT was delivered to those dogs q 3-4 wk for a total of three treatments. Short-term, in-hospital subjective lameness evaluation revealed resolution of lameness in three of nine dogs and improved lameness in six of nine dogs available for evaluation 3-4 wk following the final treatment. Long-term lameness score via telephone interview was either improved or normal in 7 of 11 dogs (64%). ESWT may result in improved function based on subjective patient evaluation and did not have any negative side effects in dogs with lameness attributable to instability, calcifying, and inflammatory conditions of the shoulder. PMID:25415219

Becker, Willem; Kowaleski, Michael P; McCarthy, Robert J; Blake, Cara A

2015-01-01

374

Seasonal dynamics of the brown dog tick, Rhipicephalus sanguineus, on a confined dog population in Italy.  

PubMed

This study evaluated the seasonal dynamics of Rhipicephalus sanguineus (Latreille) (Acari: Ixodidae) on naturally infested dogs in a private shelter in southern Italy. From March to May 2008, 39 autochthonous mixed-breed young dogs and 10 beagles were enrolled in the study. From March 2008 until March 2009, every 21 +/- 2 days, 11 body sites of each dog were checked for ticks. At each follow-up, the number of ticks, their developmental stage, sex and location on the dog's body were recorded. Adult ticks were found throughout the year, but immatures were absent in January and February. The adult tick population increased from July to August, whereas the load of immatures increased in early July and peaked in September, which suggests that R. sanguineus develops one generation per year in this area. The mean number of immature ticks per infested dog was higher than that of adults from March to October 2008. Ears, interdigital areas and armpits were the most frequent attachment sites of adult ticks. At the last follow-up, a total of 2266 ticks were collected and identified as R. sanguineus. The results suggest that R. sanguineus develops one generation per year in the study area, but that it infests dogs in all seasons. This information should be taken into account when planning control programmes against this tick species and the pathogens it transmits. PMID:20557458

Lorusso, V; Dantas-Torres, F; Lia, R P; Tarallo, V D; Mencke, N; Capelli, G; Otranto, D

2010-09-01

375

Causes of uveitis in dogs: 102 cases (1989-2000).  

PubMed

Uveitis is one of the most common ocular diseases and one of the most common causes of blindness in dogs. The purpose of this retrospective study was to correlate the signalment, history, clinical signs and ophthalmic findings of dogs with uveitis with the underlying etiology. We conducted a retrospective study of 102 dogs presented to the NCSU-VTH from 1989 to 2000 with clinical signs of uveitis. Medical records of dogs presented for uveitis were reviewed. Dogs were included in the study only if a complete diagnostic work-up database was collected, if sufficient follow-up was documented, and if the uveitis was not secondary to trauma or a hypermature cataract. The mean age +/- SD of all dogs in this study was 6.2 +/- 3.6 years. There were 33 intact and 16 castrated males, and 14 intact and 27 neutered females. Fourteen breeds were represented, with the Golden Retriever (n = 14) most common. Fifty-nine dogs (58%) were diagnosed with idiopathic/immune-mediated uveitis, neoplasia was diagnosed in 25 dogs (24.5%) and 18 dogs (17.6%) were diagnosed with infectious causes of uveitis. Aqueous flare was the most common clinical sign, occurring in 88 dogs (86%). The most common infectious organisms associated with uveitis in the dogs of this study were Ehrlichia canis (n = 7). Lymphosarcoma (n = 17) was the most common neoplasm. In approximately 60% of dogs presenting for uveitis an underlying cause was not found, and a diagnosis of immune-mediated or idiopathic uveitis was made. However, approximately 25% of dogs had ocular and/or systemic neoplasia (with 17% of cases having lymphosarcoma) and 18% with an underlying infectious cause for uveitis. Because of the high percentage of systemic disease associated with uveitis in dogs, extensive diagnostic testing is recommended before instituting symptomatic anti-inflammatory therapy. PMID:12071865

Massa, Kathleen L; Gilger, Brian C; Miller, Tammy L; Davidson, Michael G

2002-06-01

376

Diagnosis of pancreatitis in dogs and cats.  

PubMed

Pancreatitis is the most common disorder of the exocrine pancreas in both dogs and cats. Ante-mortem diagnosis of canine and feline pancreatitis can be challenging. The clinical picture of dogs and cats with pancreatitis varies greatly (from very mild to severe or even fatal) and is characterised by non-specific findings. Complete blood count, serum biochemistry profile and urinalysis should always be performed in dogs and cats suspected of having pancreatitis, although findings are not-specific for pancreatitis. Serum amylase and lipase activities and trypsin-like immunoreactivity (TLI) concentrations have no or only limited clinical value for the diagnosis of pancreatitis in either dogs or cats. Conversely, serum pancreatic lipase immunoreactivity (PLI) concentration is currently considered to be the clinicopathological test of choice for the diagnosis of canine and feline pancreatitis. Abdominal radiography is a useful diagnostic tool for the exclusion of other diseases that may cause similar clinical signs to those of pancreatitis. Abdominal ultrasonography can be very useful for the diagnosis of pancreatitis, but this depends largely on the clinician's experience. Histopathological examination of the pancreas is considered the gold standard for the diagnosis and classification of pancreatitis, but it is not without limitations. In clinical practice, a combination of careful evaluation of the animal's history, serum PLI concentration and abdominal ultrasonography, together with pancreatic cytology or histopathology when indicated or possible, is considered to be the most practical and reliable means for an accurate diagnosis or exclusion of pancreatitis compared with other diagnostic modalities. PMID:25586803

Xenoulis, P G

2015-01-01

377

Trapped Prairie Dog for SPV Testing  

USGS Multimedia Gallery

This prairie dog was trapped by scientists outside its burrow in Wind Cave National Park as part of a field test to determine the effectiveness of a USGS-developed oral sylvatic plague vaccine (SPV). This animal will be brought to a research van for tagging and blood, whisker, and hair sampling, and...

378

Trapping Prairie Dogs for Vaccine Testing  

USGS Multimedia Gallery

Greg Schroeder (National Park Service) and a pair of Auburn University graduate students approach a prairie dog that has been trapped outside its burrow in Wind Cave National Park. The animal is part of a field test to determine the effectiveness of a USGS-developed oral sylvatic plague vaccine...

379

Career Unit. Math and the Dog House.  

ERIC Educational Resources Information Center

This career exploration instructional unit is one of several resulting from the rural southwestern Colorado CEPAC Project (Career Education Process of Attitude Change). Using the construction of a dog house to give meaning to measurement skills and area computation, the unit includes (1) five behavioral objectives, the teaching strategy, the…

Peterson, Wayne

380

Clifford, The Big Red Dog K-1  

NSDL National Science Digital Library

Learning to read and write can be so much fun. Clifford, The Big Red Dog, wants to help you. Listen to a story. Here, Clifford Write a message to Clifford. Send a Note Play the Sound Match Game with Clifford. Clifford s Sound Match Game Help Clifford at the beach. Games Match your letters in the Letter Match Game. Letter Match ...

Mrs. Bourne

2006-10-16

381

Asparaginase-associated pancreatitis in a dog.  

PubMed

A dog with lymphosarcoma was evaluated for vomiting, lethargy, and abdominal pain 48 h after treatment with L-asparaginase. Based on drug administration, clinical signs, bloodwork, and elevated canine pancreatic lipase immunoreactivity, L-asparaginase-associated pancreatitis was diagnosed. This is an acknowledged toxicity; however, its pathophysiology and incidence rate in veterinary patients are unknown and sparsely documented. PMID:22379203

Schleis, Stephanie E; Rizzo, Scott A; Phillips, Jeffery C; LeBlanc, Amy K

2011-09-01

382

Umbilico-biliary fistula in a dog.  

PubMed

This case report describes a previously unreported congenital malformation, an umbilico-billary fistula, in a dog. A one-year-old male bulldog was diagnosed with umbilico-billary fistula using fistulography. Treatment involving surgical removal of the fistula was straightforward and resulted in clinical resolution of the problem. PMID:15515800

Sides, A A; Bright, R M; Mortimert, J

2004-10-01

383

POSTOPERATIVE COMPLICATIONS IN THE ONCOLOGY DOG PATIENT  

Microsoft Academic Search

Summary Objective: to investigate post0operative complications in the dogs' oncology patients Design : retrospective study of the 211 canines with cancer. Intervention: curative, palliative, or cytoreductive surgery. Results: after 211 oncology surgery 17 per cent complications were assessed; wound complication (30.5%), excessive pain (25%), hypothermia (22%), and sinus tachycardia (11%) of the total complications. Conclusion: common complications registered after the

C. IGNA; A. SALA; LARISA SCHUSZLER; M. SAB?U; C. LUCA

2009-01-01

384

Bleedling disorders in dogs : 1. Inherited disorders  

Microsoft Academic Search

BLEEDING disorders are common in dogs, can be inherited or acquired, and are associated with either single or multiple defects in the haemostatic response. The clinical nature of the bleeding can sometimes be helpful in differentiating between primary (platelet or vascular) and secondary (coagulation) defects. In addition, laboratory testing aids in the detection and differentiation of bleeding disorders. Tests such

Ian Johnstone

2002-01-01

385

Characterization of the Fecal Microbiota in Dogs with Chronic Enteropathies and Acute Hemorrhagic Diarrhea  

E-print Network

of quantitative real-time PCR (qPCR) assays for the evaluation of specific bacterial groups in fecal samples of healthy dogs, dogs with chronic enteropathies (CE), and dogs with acute hemorrhagic diarrhea (AHD). Fecal samples from 242 healthy dogs, 118 dogs...

Markel, Melissa

2012-10-19

386

Relationship between attachment to owners and separation anxiety in pet dogs ( Canis lupus familiaris)  

Microsoft Academic Search

Dogs’ dysfunctional attachment relationships with their owners are assumed to be the underlying cause of separation anxiety. Thirty-two dogs with and 43 dogs without owner-reported separation anxiety (SA) participated in a formal attachment test (AT). After the AT, the dogs were videotaped for 30 minutes while alone at home. Dogs left free in the house were scored on how long

Valli Parthasarathy; Sharon L. Crowell-Davis

2006-01-01

387

DOG AGGRESSION: CANINE BEHAVIOR AND FACTORS CONTRIBUTING TO AGGRESSION TOWARD HUMANS  

E-print Network

DOG AGGRESSION: CANINE BEHAVIOR AND FACTORS CONTRIBUTING TO AGGRESSION TOWARD HUMANS J. Kottferova1: kottfer@uvm.sk; Phone: 1421 915 984 670 Our study focused on dog aggression toward people dog owners about their dog's aggression toward unknown persons. More than half of the dogs surveyed

Champagne, Frances A.

388

[Prevalence of Strongyloides spp. infection in household dogs].  

PubMed

A total of 1,505 household dogs were investigated for the prevalence of Strongyloides spp. infection by fecal examination in relation to their fecal conditions, rearing environments, origins, age, sex and breed. Strongyloides spp. infection was demonstrated in 29 of 1,505 (1.93%) dogs. Strongyloides stercoralis was detected in 28 dogs, and Strongyloides planiceps was detected in one dog. The rate of Strongyloides spp. infection was higher in dogs reared indoors, originated from pet shops/breeding kennels and aged 1-6 months. The infected rate was higher in dogs excreting soft feces. No significant sex-related difference was observed in Strongyloides spp. infection. The rate was high in Pomeranians and low in mongrels. The detection of S. stercolaris in dogs reared indoors will involve a serious problem in public health, because the parasite has zoonoitic potential. It suggests that a positive sanitary instruction against a dog's owner and a worker in pet shops/breeding kennels seems necessary for prevention of transmission from dogs to humans. Furthermore, the reliable treatment for dogs infected with S. stercoralis seems to be important. PMID:12872692

Itoh, Naoyuki; Muraoka, Noboru; Aoki, Mikiko; Itagaki, Tadashi

2003-06-01

389

STS-69 Crew members display 'Dog Crew' patches  

NASA Technical Reports Server (NTRS)

Following their arrival at KSC's Shuttle Landing Facility, the five astronauts assigned to Space Shuttle Mission STS-69 display the unofficial crew patch for their upcoming spaceflight: the Dog Crew II patch. Mission Commander David M. Walker (center) and Payload Commander James S. Voss (second from right) previously flew together on Mission STS-53, the final dedicated Department of Defense flight on the Space Shuttle. A close comradery formed among Walker, Voss and the rest of the crew, and they dubbed themselves the 'dogs of war', with each of the STS-53 'Dog Crew' members assigned a 'dog tag' or nickname. When the STS-69 astronauts also became good buddies, they decided it was time for the Dog Crew II to be named. Walker's dog tag is Red Dog, Voss's is Dogface, Pilot Kenneth D. Cockrell (second from left) is Cujo, space rookie and Mission Specialist Michael L. Gernhardt (left) is Under Dog, and Mission Specialist James H. Newman (right) is Pluato. The Dog Crew II patch features a bulldog peering out from a doghouse shaped like the Space Shuttle and lists the five crew member's dog names. The five astronauts are scheduled to lift off on the fifth Shuttle flight of the year at 11:04 a.m. EDT, August 31, aboard the Space Shuttle Endeavour.

1995-01-01

390

Gentamicin-attenuated Leishmania infantum: a clinicopathological study in dogs.  

PubMed

The clinicopathological changes following infection with an attenuated line of Leishmania infantum (L. infantum H-line) were evaluated in mixed breed dogs. Two groups of dogs were infected intravenously (i.v.) or intradermally (i.d.) with L. infantum H-line and two control groups were infected i.v. or i.d. with L. infantum wild-type (L. infantum WT). None of the dogs, which were infected i.v. or i.d. with L. infantum H-line, showed any abnormalities during the observation period. In contrast, two out of three dogs, which were infected i.v. with L. infantum WT, developed clinical signs of disease. In addition, no histopathological changes were seen in the liver and spleen of the dogs infected with the attenuated line of parasite, whereas the histopathological changes in the two dogs infected i.v. with L. infantum WT were severe in form and manifested by infiltration of high numbers of inflammatory cells. No promastigotes were found in cultures set up from spleens and livers of dogs infected with L. infantum H-line at 12 months post-infection, whereas promastigotes were seen in the spleen and liver cultures from 2 dogs infected i.v. with L. infantum WT. Serum levels of total IgG anti-Leishmania antibody were raised in all dogs. The antibody level in the serum of dogs infected i.v. with L. infantum WT was higher than that in dogs infected with L. infantum H-line. These results show no clinicopathological abnormalities in the dogs infected with gentamicin-attenuated L. infantum H-line. Moreover, L. infantum H-line induced IgG anti-Leishmania antibody in the dogs. PMID:19147233

Daneshvar, Hamid; Molaei, Mohammad M; Afshar, Reza Malekpour; Kamiabi, Hosein; Burchmore, Richard; Hagan, Paul; Phillips, R Stephen

2009-05-15

391

Oocysts and high seroprevalence of Neospora caninum in dogs living in remote Aboriginal communities and wild dogs in Australia.  

PubMed

Canines are definitive hosts of Neospora caninum (Apicomplexa). For horizontal transmission from canines to occur, viable oocysts of N. caninum must occur in the environment of susceptible intermediate hosts. Canids in Australia include wild dogs and Aboriginal community dogs. Wild dogs are those dogs that are not dependent on humans for survival and consist of the dingo, feral domestic dog and their hybrid genotypes. Aboriginal community dogs are dependent on humans, domesticated and owned by a family, but are free-roaming and have free access throughout the community. In this study the extent of N. caninum infection was determined in a total of 374 dogs (75 wild dogs and 299 Aboriginal community dogs) using a combination of microscopic, molecular and serological techniques. Oocysts of N. caninum were observed in the faeces of two juvenile Aboriginal community dogs (2/132; 1.5%). To estimate N. caninum prevalence, a new optimised cut-off of 18.5% inhibition for a commercial competitive ELISA was calculated using a two-graph receiver-operating characteristic (TG-ROC) analysis and IFAT as the gold standard resulting in equal sensitivity and specificity of 67.8%. Of the 263 dog sera tested the true prevalence of N. caninum antibodies was 27.0% (95% confidence limit: 10.3-44.1%). The association between the competitive ELISA results in dogs less than 12 month old and older dogs was significant (P=0.042). To our knowledge this is the first large scale parasitological survey of the Aboriginal community dogs and wild dogs from Australia. The high prevalence of N. caninum infection in Aboriginal community dogs illustrates that horizontal transmission of N. caninum is occurring in Australia. These results demonstrated that N. caninum in dogs is widespread, including the semi-arid to arid regions of north-western New South Wales and the Northern Territory. The populations of free-ranging dogs are likely to be important contributors to the sylvatic life cycle of N. caninum. PMID:22245069

King, Jessica S; Brown, Graeme K; Jenkins, David J; Ellis, John T; Fleming, Peter J S; Windsor, Peter A; Slapeta, Jan

2012-06-01

392

Comparison of three methods for control of postoperative pain in dogs after total ear canal ablation with lateral bulla osteotomy  

E-print Network

provide superior postoperative analgesia. Thirty-one dogs with chronic otitis externa were included in the study. Nineteen dogs were cocker spaniels, with 10 other breeds represented. Ten dogs had previous ear surgery. Dogs were randomly assigned to three...

Buback, Janice Lynelle

1995-01-01

393

The authority of next-of-kin in explicit and presumed consent systems for deceased organ donation: an analysis of 54 nations  

PubMed Central

Background. The degree of involvement by the next-of-kin in deceased organ procurement worldwide is unclear. We investigated the next-of-kin’s authority in the procurement process in nations with either explicit or presumed consent. Methods. We collected data from 54 nations, 25 with presumed consent and 29 with explicit consent. We characterized the authority of the next-of-kin in the decision to donate deceased organs. Specifically, we examined whether the next-of-kin’s consent to procure organs was always required and whether the next-of-kin were able to veto procurement when the deceased had expressed a wish to donate. Results. The next-of-kin are involved in the organ procurement process in most nations regardless of the consent principle and whether the wishes of the deceased to be a donor were expressed or unknown. Nineteen of the 25 nations with presumed consent provide a method for individuals to express a wish to be a donor. However, health professionals in only four of these nations responded that they do not override a deceased’s expressed wish because of a family’s objection. Similarly, health professionals in only four of the 29 nations with explicit consent proceed with a deceased’s pre-existing wish to be a donor and do not require next-of-kin’s consent, but caveats still remain for when this is done. Conclusions. The next-of-kin have a considerable influence on the organ procurement process in both presumed and explicit consent nations. PMID:22121233

Rosenblum, Amanda M.; Horvat, Lucy D.; Siminoff, Laura A.; Prakash, Versha; Beitel, Janice

2012-01-01

394

?-Opioid receptor agonist injections into the presumed pre-Bötzinger complex and the surrounding region of awake goats do not alter eupneic breathing  

PubMed Central

Opioids are clinically important in the alleviation of pain. An undesirable side effect of opioids is depression of breathing. Data from isolated preparations suggest this effect is due to attenuation of discharge activity of neurons in the pre-Bötzinger complex (preBötzC), a medullary area with respiratory rhythmogenic properties. The purpose of this study was to examine how [d-Ala(2),N-Me-Phe(4),Gly(5)-ol]-enkephalin (DAMGO), a ?-opioid receptor agonist, affected breathing after injection into the presumed preBötzC of the adult awake goat. We hypothesized that DAMGO would cause breathing to decrease and become irregular when injected into the presumed preBötzC and the surrounding region of the conscious animal. We further hypothesized that ventilatory sensitivity to CO2 and hypoxia would be blunted after the injection of DAMGO. Microtubules were bilaterally implanted into the presumed preBötzC of 10 adult female goats. After recovery from the surgery, DAMGO (0.5–10 ?l, 1 nM–10 ?M) was injected into the presumed preBötzC during the awake state. DAMGO had no effect on pulmonary ventilation [inspiratory minute ventilation (V?i)], respiratory rhythm and pattern, the activation pattern of inspiratory and expiratory muscles, or arterial blood gases during eupneic breathing conditions (P > 0.10). However, DAMGO attenuated (P < 0.05) the evoked increase in breathing frequency when inspired CO2 was increased, and DAMGO attenuated the V?i response to reduction of inspired O2 to 10.8% (P < 0.05). We conclude that our data do not provide support for the concept that in awake mammals opioid depression of breathing is due to a directed action of opioids on preBötzC neurons. PMID:19745186

Neumueller, S. E.; Marshall, B. D.; Kiner, T.; Bonis, J. M.; Pan, L. G.; Qian, B.; Forster, H. V.

2009-01-01

395

Diversity of Blastocystis subtypes in dogs in different geographical settings  

PubMed Central

Background Blastocystis is a ubiquitous, globally distributed intestinal protist infecting humans and a wide range of animals. Several studies have shown that Blastocystis is a potentially zoonotic parasite. A 1996 study reported a 70% Blastocystis prevalence in Brisbane pound dogs while another study found that pet dogs/cats of 11 symptomatic Blastocystis infected patients harboured at least one Blastocystis subtype (ST) in common with the patient. These results raised the possibility that dogs might be natural hosts of Blastocystis. In this study, we aimed to investigate this hypothesis by estimating the prevalence of Blastocystis carriage and characterising the diversity of STs in dogs from three different environmental settings and comparing these STs with the range that humans harbour. Methods Two hundred and forty faecal samples from dogs from three different geographical regions with varying levels of socio-economic development and sanitation, namely i) 80 pet and pound dogs from Brisbane, Australia, ii) 80 semi-domesticated dogs from Dong Village, Cambodia and iii) 80 stray dogs from the densely populated cities of Sikkim, Delhi and Mumbai in India, were screened for Blastocystis using PCR and subtyped based on the “barcode region” of the small subunit ribosomal RNA (SSU rRNA) gene. Results The prevalence of Blastocystis in dogs from Brisbane and Cambodia was 2.5% (2/80) and 1.3% (1/80), respectively, in contrast to 24% (19/80) in stray dogs from India. Stray dogs in India carried a diverse range of Blastocystis STs including ST 1, 4, 5 and 6 while the dogs from Brisbane carried only ST1 and one Cambodian dog carried ST2. Conclusion The results suggest there is geographical variation in Blastocystis prevalence and STs between dog populations as reported in human studies. In addition, the greater diversity of STs and higher prevalence of Blastocystis in Indian stray dogs compared to pet/pound and community dogs in Australia and Cambodia could reflect close proximity to humans and other animals and exposure to their faeces. It appears that dogs are not natural hosts for Blastocystis but rather are transiently and opportunistically infected with a diversity of STs. PMID:23883734

2013-01-01

396

The dog as a passive smoker: effects of exposure to environmental cigarette smoke on domestic dogs.  

PubMed

Of the few studies available regarding the effects of smoking on animals, most of them involve animals actively smoking through the use of a mask or tracheostomy. The present study investigated the effects of passive smoke exposure on domestic dogs. The sample comprised 30 Yorkshire terriers (18 males) ranging in age from 27 to 106 months (M = 38.6+/-15.8) and weighing 1.9-4.0 kg (M = 3.04+/-0.48). Half of the dogs came from homes where residents smoked at least 20 cigarettes/day for a minimum of 24 months, and the other half were from homes without smokers. All animals were subjected to bronchoalveolar lavage to determine cell populations and the presence of anthracosis in macrophage cytoplasm; in addition, a carinal biopsy was obtained. To characterize environmental cigarette smoke exposure, urinary cotinine was determined by an immunochromatographic assay. Cotinine was not detected in the urine of dogs not exposed to cigarette smoke, whereas exposed dogs tested positive. In dogs exposed to cigarette smoke, macrophage and lymphocyte populations were significantly increased (p<.05) and anthracosis was present in the cytoplasm of macrophages. The measurement of urinary cotinine by an immunochromatographic assay is an effective method that can be used to confirm environmental tobacco exposure. Cytological analysis of bronchoalveolar lavage fluid demonstrated airway alterations triggered by passive exposure to tobacco smoke in domestic animals. PMID:17978991

Roza, Marcello Rodrigues; Viegas, Carlos Alberto Assis

2007-11-01

397

In Dogs We Trust? Intersubjectivity, Response-Able Relations, and the Making of Mine Detector Dogs  

PubMed Central

The utility of the dog as a mine detector has divided the mine clearance community since dogs were first used for this purpose during the Second World War. This paper adopts a historical perspective to investigate how, why, and to what consequence, the use of minedogs remains contested despite decades of research into their abilities. It explores the changing factors that have made it possible to think that dogs could, or could not, serve as reliable detectors of landmines over time. Beginning with an analysis of the wartime context that shaped the creation of minedogs, the paper then examines two contemporaneous investigations undertaken in the 1950s. The first, a British investigation pursued by the anatomist Solly Zuckerman, concluded that dogs could never be the mine hunter's best friend. The second, an American study led by the parapsychologist J. B. Rhine, suggested dogs were potentially useful for mine clearance. Drawing on literature from science studies and the emerging subdiscipline of “animal studies,” it is argued that cross-species intersubjectivity played a significant role in determining these different positions. The conceptual landscapes of Zuckerman and Rhine's disciplinary backgrounds are shown to have produced distinct approaches to managing cross-species relations, thus explaining how diverse opinions on minedog can coexist. In conclusion, it is shown that the way one structures relationships between humans and animals has profound impact on the knowledge and labor subsequently produced, a process that cannot be separated from ethical consequence. PMID:24318987

Kirk, Robert G W

2014-01-01

398

Survival of Skin Graft between Transgenic Cloned Dogs and Non-Transgenic Cloned Dogs  

PubMed Central

Whereas it has been assumed that genetically modified tissues or cells derived from somatic cell nuclear transfer (SCNT) should be accepted by a host of the same species, their immune compatibility has not been extensively explored. To identify acceptance of SCNT-derived cells or tissues, skin grafts were performed between cloned dogs that were identical except for their mitochondrial DNA (mtDNA) haplotypes and foreign gene. We showed here that differences in mtDNA haplotypes and genetic modification did not elicit immune responses in these dogs: 1) skin tissues from genetically-modified cloned dogs were successfully transplanted into genetically-modified cloned dogs with different mtDNA haplotype under three successive grafts over 63 days; and 2) non-transgenic cloned tissues were accepted into transgenic cloned syngeneic recipients with different mtDNA haplotypes and vice versa under two successive grafts over 63 days. In addition, expression of the inserted gene was maintained, being functional without eliciting graft rejection. In conclusion, these results show that transplanting genetically-modified tissues into normal, syngeneic or genetically-modified recipient dogs with different mtDNA haplotypes do not elicit skin graft rejection or affect expression of the inserted gene. Therefore, therapeutically valuable tissue derived from SCNT with genetic modification might be used safely in clinical applications for patients with diseased tissues. PMID:25372489

Kim, Geon A; Oh, Hyun Ju; Kim, Min Jung; Jo, Young Kwang; Choi, Jin; Park, Jung Eun; Park, Eun Jung; Lim, Sang Hyun; Yoon, Byung Il; Kang, Sung Keun; Jang, Goo; Lee, Byeong Chun

2014-01-01

399

Characterization of the dog agouti gene and a nonagouti mutation in german shepherd dogs  

SciTech Connect

The interaction between two genes, Agouti and Melanocortin-1 receptor (Mc1r), produces diverse pigment patterns in mammals by regulating the type, amount, and distribution pattern of the two pigment types found in mammalian hair: eumelanin (brown/black) and pheomelanin (yellow/red). In domestic dogs (Canis familiaris), there is a tremendous variation in coat color patterns between and within breeds; however, previous studies suggest that the molecular genetics of pigment-type switching in dogs may differ from that of other mammals. Here we report the identification and characterization of the Agouti gene from domestic dogs, predicted to encode a 131-amino-acid secreted protein 98 percent identical to the fox homolog, and which maps to chromosome CFA24 in a region of conserved linkage. Comparative analysis of the Doberman Pinscher Agouti cDNA, the fox cDNA, and 180 kb of Doberman Pinscher genomic DNA suggests that, as with laboratory mice, different pigment-type-switching patterns in the canine family are controlled by alternative usage of different promoters and untranslated first exons. A small survey of Labrador Retrievers, Greyhounds, Australian Shepherds, and German Shepherd Dogs did not uncover any polymorphisms, but we identified a single nucleotide variant in black German Shepherd Dogs predicted to cause an Arg-to-Cys substitution at codon 96, which is likely to account for recessive inheritance of a uniform black coat.

Kerns, Julie A.; Newton, J.; Berryere, Tom G.; Rubin, Edward M.; Cheng, Jan-Fang; Schmutz, Sheila M.; Barsh, Gregory S.

2004-07-08

400

Lipoprotein metabolism and LCAT activity in chronic renal failure dogs supplemented with PUFA oils  

E-print Network

Serum total cholesterol (TC), lipoprotein cholesterol distribution, and lecithin:cholesterol acyltransferase (LCAT) activities of chronic renal failure dogs were investigated. Control dogs (n = 14) and affected dogs (n = 29) were fed one of three...

Malcik, Kimberly L

1996-01-01

401

49 CFR 236.338 - Mechanical locking required in accordance with locking sheet and dog chart.  

Code of Federal Regulations, 2014 CFR

...required in accordance with locking sheet and dog chart. 236.338 Section 236.338...required in accordance with locking sheet and dog chart. Mechanical locking shall be in accordance with locking sheet and dog chart currently in...

2014-10-01

402

49 CFR 236.338 - Mechanical locking required in accordance with locking sheet and dog chart.  

Code of Federal Regulations, 2010 CFR

...required in accordance with locking sheet and dog chart. 236.338 Section 236.338...required in accordance with locking sheet and dog chart. Mechanical locking shall be in accordance with locking sheet and dog chart currently in...

2010-10-01

403

33 CFR 147.839 - Mad Dog Truss Spar Platform safety zone.  

Code of Federal Regulations, 2010 CFR

...2010-07-01 2010-07-01 false Mad Dog Truss Spar Platform safety zone. 147...ACTIVITIES SAFETY ZONES § 147.839 Mad Dog Truss Spar Platform safety zone. (a) Description. Mad Dog Truss Spar Platform, Green Canyon 782...

2010-07-01

404

49 CFR 236.335 - Dogs, stops and trunnions of mechanical locking.  

Code of Federal Regulations, 2011 CFR

...2011-10-01 2011-10-01 false Dogs, stops and trunnions of mechanical locking... Rules and Instructions § 236.335 Dogs, stops and trunnions of mechanical locking. Driving pieces, dogs, stops and trunnions shall be...

2011-10-01

405

49 CFR 236.335 - Dogs, stops and trunnions of mechanical locking.  

Code of Federal Regulations, 2013 CFR

...2013-10-01 2013-10-01 false Dogs, stops and trunnions of mechanical locking... Rules and Instructions § 236.335 Dogs, stops and trunnions of mechanical locking. Driving pieces, dogs, stops and trunnions shall be...

2013-10-01

406

49 CFR 236.335 - Dogs, stops and trunnions of mechanical locking.  

Code of Federal Regulations, 2012 CFR

...2012-10-01 2012-10-01 false Dogs, stops and trunnions of mechanical locking... Rules and Instructions § 236.335 Dogs, stops and trunnions of mechanical locking. Driving pieces, dogs, stops and trunnions shall be...

2012-10-01

407

49 CFR 236.335 - Dogs, stops and trunnions of mechanical locking.  

Code of Federal Regulations, 2014 CFR

...2014-10-01 2014-10-01 false Dogs, stops and trunnions of mechanical locking... Rules and Instructions § 236.335 Dogs, stops and trunnions of mechanical locking. Driving pieces, dogs, stops and trunnions shall be...

2014-10-01

408

33 CFR 147.839 - Mad Dog Truss Spar Platform safety zone.  

Code of Federal Regulations, 2012 CFR

...2012-07-01 2012-07-01 false Mad Dog Truss Spar Platform safety zone. 147...ACTIVITIES SAFETY ZONES § 147.839 Mad Dog Truss Spar Platform safety zone. (a) Description. Mad Dog Truss Spar Platform, Green Canyon 782...

2012-07-01

409

33 CFR 147.839 - Mad Dog Truss Spar Platform safety zone.  

Code of Federal Regulations, 2011 CFR

...2011-07-01 2011-07-01 false Mad Dog Truss Spar Platform safety zone. 147...ACTIVITIES SAFETY ZONES § 147.839 Mad Dog Truss Spar Platform safety zone. (a) Description. Mad Dog Truss Spar Platform, Green Canyon 782...

2011-07-01

410

49 CFR 236.338 - Mechanical locking required in accordance with locking sheet and dog chart.  

Code of Federal Regulations, 2012 CFR

...required in accordance with locking sheet and dog chart. 236.338 Section 236.338...required in accordance with locking sheet and dog chart. Mechanical locking shall be in accordance with locking sheet and dog chart currently in...

2012-10-01

411

49 CFR 236.338 - Mechanical locking required in accordance with locking sheet and dog chart.  

Code of Federal Regulations, 2013 CFR

...required in accordance with locking sheet and dog chart. 236.338 Section 236.338...required in accordance with locking sheet and dog chart. Mechanical locking shall be in accordance with locking sheet and dog chart currently in...

2013-10-01

412

49 CFR 236.338 - Mechanical locking required in accordance with locking sheet and dog chart.  

Code of Federal Regulations, 2011 CFR

...required in accordance with locking sheet and dog chart. 236.338 Section 236.338...required in accordance with locking sheet and dog chart. Mechanical locking shall be in accordance with locking sheet and dog chart currently in...

2011-10-01

413

49 CFR 236.335 - Dogs, stops and trunnions of mechanical locking.  

Code of Federal Regulations, 2010 CFR

...2010-10-01 2010-10-01 false Dogs, stops and trunnions of mechanical locking... Rules and Instructions § 236.335 Dogs, stops and trunnions of mechanical locking. Driving pieces, dogs, stops and trunnions shall be...

2010-10-01

414

33 CFR 147.839 - Mad Dog Truss Spar Platform safety zone.  

Code of Federal Regulations, 2014 CFR

...2014-07-01 2014-07-01 false Mad Dog Truss Spar Platform safety zone. 147...ACTIVITIES SAFETY ZONES § 147.839 Mad Dog Truss Spar Platform safety zone. (a) Description. Mad Dog Truss Spar Platform, Green Canyon 782...

2014-07-01

415

33 CFR 147.839 - Mad Dog Truss Spar Platform safety zone.  

Code of Federal Regulations, 2013 CFR

...2013-07-01 2013-07-01 false Mad Dog Truss Spar Platform safety zone. 147...ACTIVITIES SAFETY ZONES § 147.839 Mad Dog Truss Spar Platform safety zone. (a) Description. Mad Dog Truss Spar Platform, Green Canyon 782...

2013-07-01

416

Experimental infection of equine herpesvirus 9 in dogs.  

PubMed

Equine herpesvirus 9 (EHV-9), a new neurotropic equine herpesvirus, was inoculated intranasally at 107 plaque-forming units in five dogs to assess its pathogenicity. Dogs showed weight loss, pyrexia, anorexia, and neurologic signs on the fourth day. The EHV-9 virus was recovered from the examined brains. Histologically, dogs had a fulminant nonsuppurative encephalitis characterized by severe neuronal degeneration and loss, with intranuclear inclusions, slight glial reactions, perivascular cuffing, and multifocal hemorrhage. The olfactory bulb and the frontal and temporal lobes were predominantly affected. Immunohistochemistry revealed reactivity for EHV-9 antigen in neurons. All dogs had mild bronchopneumonia and various degrees of lymphoid necrosis. These findings indicate that dogs are fully susceptible to EHV-9 and that EHV-9 can cause fulminant encephalitis with high mortality in dogs, as in gazelles and goats. PMID:12724566

Yanai, T; Fujishima, N; Fukushi, H; Hirata, A; Sakai, H; Masegi, T

2003-05-01

417

Breed-Predispositions to Cancer in Pedigree Dogs  

PubMed Central

Cancer is a common problem in dogs and although all breeds of dog and crossbred dogs may be affected, it is notable that some breeds of pedigree dogs appear to be at increased risk of certain types of cancer suggesting underlying genetic predisposition to cancer susceptibility. Although the aetiology of most cancers is likely to be multifactorial, the limited genetic diversity seen in purebred dogs facilitates genetic linkage or association studies on relatively small populations as compared to humans, and by using newly developed resources, genome-wide association studies in dog breeds are proving to be a powerful tool for unravelling complex disorders. This paper will review the literature on canine breed susceptibility to histiocytic sarcoma, osteosarcoma, haemangiosarcoma, mast cell tumours, lymphoma, melanoma, and mammary tumours including the recent advances in knowledge through molecular genetic, cytogenetic, and genome wide association studies. PMID:23738139

Dobson, Jane M.

2013-01-01

418

Evidence of an oncogenic gammaherpesvirus in domestic dogs  

SciTech Connect

In humans, chronic infection with the gammaherpesvirus Epstein-Barr virus is usually asymptomatic; however some infected individuals develop hematological and epithelial malignancies. The exact role of EBV in lymphomagenesis is poorly understood partly because of the lack of clinically relevant animal models. Here we report the detection of serological responses against EBV capsid antigens in healthy dogs and dogs with spontaneous lymphoma and that dogs with the highest antibody titers have B cell lymphoma. Moreover, we demonstrate the presence of EBV-like viral DNA and RNA sequences and Latent Membrane Protein-1 in malignant lymph nodes of dogs with lymphoma. Finally, electron microscopy of canine malignant B cells revealed the presence of classic herpesvirus particles. These findings suggest that dogs can be naturally infected with an EBV-like gammaherpesvirus that may contribute to lymphomagenesis and that dogs might represent a spontaneous model to investigate environmental and genetic factors that influence gammaherpesvirus-associated lymphomagenesis in humans.

Huang, Shih-Hung, E-mail: ncku309@gmail.com [Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, 335 Hill Pavilion, 380 South University Avenue, Philadelphia, PA 19104-6010 (United States)] [Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, 335 Hill Pavilion, 380 South University Avenue, Philadelphia, PA 19104-6010 (United States); Kozak, Philip J., E-mail: philj@vet.upenn.edu [Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, 335 Hill Pavilion, 380 South University Avenue, Philadelphia, PA 19104-6010 (United States); Kim, Jessica, E-mail: jesskim820@gmail.com [Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, 335 Hill Pavilion, 380 South University Avenue, Philadelphia, PA 19104-6010 (United States)] [Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, 335 Hill Pavilion, 380 South University Avenue, Philadelphia, PA 19104-6010 (United States); Habineza-Ndikuyeze, Georges, E-mail: georgesh@vet.upenn.edu [Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, 335 Hill Pavilion, 380 South University Avenue, Philadelphia, PA 19104-6010 (United States)] [Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, 335 Hill Pavilion, 380 South University Avenue, Philadelphia, PA 19104-6010 (United States); Meade, Charles, E-mail: cmeade@vet.upenn.edu [Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, 335 Hill Pavilion, 380 South University Avenue, Philadelphia, PA 19104-6010 (United States)] [Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, 335 Hill Pavilion, 380 South University Avenue, Philadelphia, PA 19104-6010 (United States); Gaurnier-Hausser, Anita, E-mail: anitag@vet.upenn.edu [Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, 335 Hill Pavilion, 380 South University Avenue, Philadelphia, PA 19104-6010 (United States)] [Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, 335 Hill Pavilion, 380 South University Avenue, Philadelphia, PA 19104-6010 (United States); Patel, Reema, E-mail: rtpatel@vet.upenn.edu [Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, 315 Hill Pavilion, 380 South University Avenue, Philadelphia, PA 19104-6010 (United States)] [Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, 315 Hill Pavilion, 380 South University Avenue, Philadelphia, PA 19104-6010 (United States); Robertson, Erle, E-mail: erle@mail.med.upenn.edu [Department of Microbiology, and Abramson Comprehensive Cancer Center, Tumor Virology Program, University of Pennsylvania, 202A Johnson Pavilion, 3610 Hamilton Walk, Philadelphia, PA 19104-6076 (United States)] [Department of Microbiology, and Abramson Comprehensive Cancer Center, Tumor Virology Program, University of Pennsylvania, 202A Johnson Pavilion, 3610 Hamilton Walk, Philadelphia, PA 19104-6076 (United States); and others

2012-06-05

419

Response and adaptation of Beagle dogs to hypergravity  

NASA Technical Reports Server (NTRS)

Eight male Beagle dogs, five months old, were centrifuged continuously for three months at progressively increasing loads. Heart rate and deep body temperature were monitored continuously by implant biotelemetry. Initially, centrifuged dogs showed transient decreases in heart rate and body temperature along with changes in their diurnal rhythm patterns. Compared with normal gravity controls, exposed dogs showed a slower growth rate and a reduced amount of body fat. Blood protein, total lipids, cholesterol, calcium, packed cell volume, red blood cell count, and hemoglobin were also decreased significantly. Absolute weights of the leg bones of centrifuged dogs were significantly greater than controls. Photon absorptiometry revealed significant density increases in selective regions of the femur and humerus of centrifuged dogs. In spite of the various changes noted, results from this and other studies affirm the view that dogs can tolerate and adapt to sustained loads as high as 2.5 g without serious impairment of their body structure and function.

Oyama, J.

1975-01-01

420

Canine Connection: Dog 2--Fun Activities for You and Your Dog. 4-H Skills for Life Animal Series. National 4-H Curriculum. BU-08167  

ERIC Educational Resources Information Center

Youth explore more about dog health, nutrition, and care, genetic problems, population control, showmanship, training, ethics and budgeting. Youth who engage in this curriculum will develop essential dog project skills such as selecting a dog; investigating breeds; appreciating dogs' places and roles in society; practicing grooming, fitting,…

National 4-H Council, 2005

2005-01-01

421

SOURCE: http://articles.cnn.com/2010-11-18/living/intelligent.dog.psychology_1_dogs-brian-hare-problems?_s=PM:LIVING accessed 12 Nov 2012  

E-print Network

SOURCE: http://articles.cnn.com/2010-11-18/living/intelligent.dog.psychology_1_dogs-brian-hare- problems?_s=PM:LIVING accessed 12 Nov 2012 Inside the science of how dogs think CNN Living: WORLD November toy! Ever wonder what your dog is thinking as it gazes at you while you are barking commands? Duke

Packard, Jane M.

422

All About the Dogs 4-H Weekend -2012 In June, the Rolling Bones 4-H Dog Club of Merrimack county held its fifteenth  

E-print Network

All About the Dogs 4-H Weekend - 2012 In June, the Rolling Bones 4-H Dog Club of Merrimack county held its fifteenth annual All About the Dogs weekend at the 4-H Youth Center in New Boston, NH. This clinic provides a canine training-themed weekend for children enrolled in the 4-H Dog Program

New Hampshire, University of

423

Leading the Pack: Dog 3--Fun Activities for You and Your Dog. 4-H Skills for Life Animal Series. National 4-H Curriculum. BU-08168  

ERIC Educational Resources Information Center

Experienced youth investigate responsible breeding, diseases, caring for geriatric dogs, training, service dogs, dog roles and careers related to dogs. This guide provides youth with numerous leadership opportunities. Because youth development programs help build tomorrow's leaders, leadership is a strong theme in Level 3 activities. One will be…

National 4-H Council, 2005

2005-01-01

424

Nasal and oral masses in a dog.  

PubMed

A 5-year-old, intact male, stray dog was presented in poor body condition, with pallor, muzzle deformity, multiple oozing fistulas with grass awns, bilateral sanguinopurulent nasal discharge and a fleshy friable mass occupying part of the hard palate. A friable mass occupying both nasal cavities was found on rhinoscopy. The dog had moderate nonregenerative normochromic-microcytic anemia, thrombocytopenia, hyperglobulinemia, and hypoalbuminemia. Cytologic preparations of the nasal and oral masses contained a neoplastic population of round cells with intracytoplasmic and extracellular vacuoles. Leishmania amastigotes also were observed, in the cytoplasm of macrophages and, occasionally, within neoplastic cells. A diagnosis of transmissible venereal tumor and concurrent leishmaniosis was made. Treatment with vincristine and allopurinol resulted in complete resolution of clinical signs and disappearance of the masses. The presence of amastigotes in neoplastic TVT cells may suggest an alternative mode of transmission of canine leishmaniosis where these diseases co-exist. PMID:16511802

Levy, Esther; Mylonakis, Mathios E; Saridomichelakis, Manolis N; Polizopoulou, Zoe S; Psychogios, Vassilios; Koutinas, Alexander F

2006-03-01

425

Surgical management of syndactyly in a dog.  

PubMed

This report describes the treatment of simple syndactyly in a Golden Retriever. The left forepaw lacked cutaneous separation between the digits and had confluent metacarpal and digital pads. After vigorous exercise, the dog had intermittent non-weight-bearing lameness involving the affected forepaw. The lameness may have resulted from stretching of the thin skin on the dorsum of the paw as the digits attempted to spread during weight bearing. Surgical separation of digits 3 and 4 was performed by creating an interdigital web space with dorsal and palmar skin flaps and by covering the exposed axial surfaces with full-thickness skin grafts. At 11 weeks after surgery, the lameness had improved and the dog's level of activity had increased. PMID:7890572

Richardson, E F; Wey, P D; Hoffman, L A

1994-10-15

426

Skeletal-extraskeletal angiomatosis in a dog.  

PubMed

An 8-year-old castrated male mixed-breed dog had an ill-defined hemorrhagic and painful lesion in the base of the claw of the second digit of the right forelimb. Radiographically, the expansile and lytic lesion affected the distal phalanx. The digit was amputated and submitted for histologic examination. Histologically, the distal phalanx was largely replaced by a mass composed of variably sized cavernous vascular spaces lined by a single layer of flattened endothelial cells. A similar mass was in the subcutis adjacent to the distal phalanx. The benign vascular proliferation involving the medulla of bone and a second tissue type in this dog is consistent with skeletal-extraskeletal angiomatosis as described in humans. To the authors' knowledge, this is the first report of skeletal-extraskeletal angiomatosis in the veterinary literature. PMID:20466862

Kuroki, K; Britt, L G; Franklin, S P; Henry, C J

2010-09-01

427

Lack of arrhythmogenicity of aminophylline in dogs.  

PubMed

This study was designed to determine if doses of aminophylline up to 10 mg/kg given i.v. would produce ventricular arrhythmias in seven healthy dogs anaesthetized with fentanyl-droperidol-pentobarbital. Arrhythmias were sought by inspection of ECGs before and after attempts at provoking them with 5 micrograms/kg boluses of epinephrine given i.v., or by programmed electrical stimulation. After cumulative doses of 10 mg aminophylline/kg body weight, producing an estimated plasma concentration of greater than 30 micrograms/ml, no ventricular ectopia other than escape depolarizations were observed. We were unable to document an arrhythmogenic effect of aminophylline when given rapidly by the i.v. route. It is possible that the anaesthetic regimen reduced the arrhythmogenic property of aminophylline, or that arrhythmias might be produced in either obese or ill dogs; but it is unlikely that chronic administration of aminophylline would be more arrhythmogenic. PMID:8478996

Hamlin, R L; Sally, J L

1993-03-01

428

Mycobacterium fortuitum lipoid pneumonia in a dog.  

PubMed

A 1-year old female spayed German Shepherd dog was evaluated for acute onset of dyspnea. Pyogranulomatous inflammation and green globoid structures were present on aspirates of the affected lung. Impression smears and histopathology confirmed pyogranulomatous pneumonia, with large amounts of lipid corresponding to the green structures noted cytologically, and identified poorly staining bacterial rods within lipid vacuoles. Special stains confirmed the presence of acid-fast bacterial rods, and polymerase chain reaction and DNA sequencing identified the organism as Mycobacterium fortuitum. M. fortuitum pneumonia is well described in humans and has previously been reported in 4 dogs and 1 cat. Lipid was a prominent cytologic and histologic feature, as is often described in humans and in the single feline case report. Additionally, this case highlights the variable cytologic appearance of lipid, as well as Mycobacterium spp, which are classically nonstaining with Wright-Giemsa. PMID:24788402

Leissinger, M K; Garber, J B; Fowlkes, N; Grooters, A M; Royal, A B; Gaunt, S D

2015-03-01

429

Clinical pharmacology of clemastine in healthy dogs.  

PubMed

The pharmacokinetic properties of clemastine were investigated in six healthy dogs and compared with the effect of the drug recorded as inhibition of wheal formation induced by intradermal injections of histamine. Clemastine clearance was high (median: 2.1 L h(-1) kg(-1)) and the volume of distribution large (13.4 L kg(-1)). The half-life after intravenous administration was 3.8 h and the plasma protein binding level in vitro was 98%. After oral administration, the bioavailability was only 3%. Given intravenously, clemastine (0.1 mg kg(-1)) inhibited wheal formation completely for 7 h, whereas the effect after oral administration (0.5 mg kg(-1)) was minor. The data show that most dosage regimens suggested in the literature for the oral administration of clemastine to dogs are likely to give too low a systemic exposure of the drug to allow effective therapy. PMID:15214951

Hansson, H; Bergvall, K; Bondesson, U; Hedeland, M; Törneke, K

2004-06-01

430

Renal parameter estimates in unrestrained dogs  

NASA Technical Reports Server (NTRS)

A mathematical formulation has been developed to describe the hemodynamic parameters of a conceptualized kidney model. The model was developed by considering regional pressure drops and regional storage capacities within the renal vasculature. Estimation of renal artery compliance, pre- and postglomerular resistance, and glomerular filtration pressure is feasible by considering mean levels and time derivatives of abdominal aortic pressure and renal artery flow. Changes in the smooth muscle tone of the renal vessels induced by exogenous angiotensin amide, acetylcholine, and by the anaesthetic agent halothane were estimated by use of the model. By employing totally implanted telemetry, the technique was applied on unrestrained dogs to measure renal resistive and compliant parameters while the dogs were being subjected to obedience training, to avoidance reaction, and to unrestrained caging.

Rader, R. D.; Stevens, C. M.

1974-01-01

431

Prevalence of Giardia lamblia infection in household dogs.  

PubMed

A total of 1035 household dogs were examined for the presence of Giardia lamblia (G. lamblia) in their feces. Fecal samples from 151 (14.6%) of the dogs were positive for Giardia. The protozoan was more often detected in soft feces (26.4%) than in normal (10.0%) or diarrheic feces (13.7%) (p < 0.001 and p < 0.01, respectively). The forms of the organisms obtained from the 151 dogs were cysts (77.5%), trophozoites (9.9%), or both cysts and trophozoites (12.6%). Dogs kept indoors had a higher prevalence (18.5%) of Giardia than dogs kept outdoors (4.8%) (p < 0.001). Giardia infection was also more prevalent in 1-6 months old puppies (21.7%) compared to other groups (2.4%-7.5%) (p < 0.001). The prevalence of Giardia in dogs originally purchased from pet shops or breeding kennels was extremely high (21.5%) compared to that of dogs from individual households (4.3%) (p < 0.001). With regard to human public health, the high infection rate of Giardia in puppies and dogs kept indoors is a serious problem because G. lamblia in infected dogs may have zoonotic potential. No reports of human giardiasis transmitted from dogs have been made. However, the results of this study suggest that the risk of Giardia transmission from household dogs to humans is not negligible. Pet owners should be taught appropriate hygiene measures to prevent Giardia transmission from dogs to humans. PMID:11558129

Itoh, N; Muraoka, N; Aoki, M; Itagaki, T

2001-08-01

432

The Skin Microbiome in Healthy and Allergic Dogs  

PubMed Central

Background Changes in the microbial populations on the skin of animals have traditionally been evaluated using conventional microbiology techniques. The sequencing of bacterial 16S rRNA genes has revealed that the human skin is inhabited by a highly diverse and variable microbiome that had previously not been demonstrated by culture-based methods. The goals of this study were to describe the microbiome inhabiting different areas of the canine skin, and to compare the skin microbiome of healthy and allergic dogs. Methodology/Principal Findings DNA extracted from superficial skin swabs from healthy (n?=?12) and allergic dogs (n?=?6) from different regions of haired skin and mucosal surfaces were used for 454-pyrosequencing of the 16S rRNA gene. Principal coordinates analysis revealed clustering for the different skin sites across all dogs, with some mucosal sites and the perianal regions clustering separately from the haired skin sites. The rarefaction analysis revealed high individual variability between samples collected from healthy dogs and between the different skin sites. Higher species richness and microbial diversity were observed in the samples from haired skin when compared to mucosal surfaces or mucocutaneous junctions. In all examined regions, the most abundant phylum and family identified in the different regions of skin and mucosal surfaces were Proteobacteria and Oxalobacteriaceae. The skin of allergic dogs had lower species richness when compared to the healthy dogs. The allergic dogs had lower proportions of the Betaproteobacteria Ralstonia spp. when compared to the healthy dogs. Conclusions/Significance The study demonstrates that the skin of dogs is inhabited by much more rich and diverse microbial communities than previously thought using culture-based methods. Our sequence data reveal high individual variability between samples collected from different patients. Differences in species richness was also seen between healthy and allergic dogs, with allergic dogs having lower species richness when compared to healthy dogs. PMID:24421875

Rodrigues Hoffmann, Aline; Patterson, Adam P.; Diesel, Alison; Lawhon, Sara D.; Ly, Hoai Jaclyn; Stephenson, Christine Elkins; Mansell, Joanne; Steiner, Jörg M.; Dowd, Scot E.; Olivry, Thierry; Suchodolski, Jan S.

2014-01-01

433

Spontaneous Testicular Lesions in Purpose-Bred Beagle Dogs  

Microsoft Academic Search

Spontaneous testicular lesions were assessed in 50 control purpose-bred male beagle dogs. They were selected from 13 toxicology studies conducted over the period 1988-1999. Age of the dogs at study termination varied from 8-20 months with an average age of 13 months. Regardless of age, the most significant finding was bilateral segmental hypospermatogenesis in 15\\/50 (30%) of the dogs. Cross

S. Rehm

2000-01-01

434

Attacks by packs of dogs involving predation on human beings  

PubMed Central

Dog bites are a medical problem for millions of people, children being the most common victims. Human deaths attributable to dog bite injury (not rabies) are relatively infrequent. There have been some epidemiologic reviews, but this study is the first attempt to arrive at an understanding of bites involving predation on human beings by conducting behavioral examinations under controlled conditions of the dogs involved, and by interviewing victims, witnesses, and people familiar with the animals. The three cases studied involved two fatalities and an attack that was nearly fatal. The victims were 11, 14, and 81. In each case, owned pet dogs consumed some human tissue. The severity of the victims' injuries was not the consequence of a single dog bite, but the result of repeated attacks by dogs behaving as a social group. Factors that might contribute to a dog's regarding human beings as potential prey were examined, including hunger, prior predation, group behaviors, defense of territory, previous interactions with people, the presence of estrous female dogs, and environmental stimuli. In two of the cases, it was possible, by using similar stimuli, to duplicate the circumstances at the time of the attack. The results of the observations showed the value of behavioral analysis and simulations methods in evaluating possible factors in dog attacks. Among the many factors probably involved in severe dog attacks are the size, number, and nutritional status of the dogs; the dogs' previous aggressive contacts with people; the victim's age, size, health, and behavior; and the absence of other human beings in the vicinity. Imagesp61-ap61-bp61-c PMID:6828639

Borchelt, Peter L.; Lockwood, Randall; Beck, Alan M.; Voith, Victoria L.

1983-01-01

435

Tolerance to cold and glucose homeostasis in adrenal demedullated dogs.  

PubMed

The rise in O2 consumption and in glucose turnover, induced by acute cold exposure is not suppressed by adrenal demedullation in dogs. However, both at neutral and cold ambient temperature, the mean plasma glucose concentrations are higher in normal (N) than in adrenal-demedullated dogs (ADMX). In the cold, the fall in rectal temperature is larger in ADMX than in N dogs. PMID:891816

Forichon, J; Jomain, M J; Patricot, M C; Minaire, Y

1977-08-15

436

Factors influencing the antibody response of dogs vaccinated against rabies  

Microsoft Academic Search

Since 2000, there has been a legal requirement in the UK that dogs and cats should have an effective rabies vaccination with demonstrable sero-conversion if their owners wish to avoid quarantine on re-entry to the UK. In 2002, 10,483 rabies titres were determined on dogs at the VLA. Statistical analyses assessed the efficacy of each vaccine within different dog breeds.

Lorna J. Kennedy; Mark Lunt; Annette Barnes; Lorraine McElhinney; Anthony R. Fooks; David N. Baxter; William E. R. Ollier

2007-01-01

437

A Comparison of Tethering and Pen Confinement of Dogs  

Microsoft Academic Search

This study compared general activity and specific behaviors of 30 adult Alaskan sled dogs, 19 male and 11 female dogs, on 3.5 m tethers and in 5.9 m2 pens. The investiga- tors used activity level and steriotypies as indicators of welfare. The dogs spent most of their time inactive, either lying or sitting both on the tether and in the

Seong C. Yeon; Glen Golden; Wailani Sung; Hollis N. Erb; Arleigh J. Reynolds; Katherine A. Houpt

2001-01-01

438

Ultrasonographic characteristics of the abdominal esophagus and cardia in dogs.  

PubMed

Differential diagnoses for regurgitation and vomiting in dogs include diseases of the gastroesophageal junction. The purpose of this cross-sectional study was to describe ultrasonographic characteristics of the abdominal esophagus and gastric cardia in normal dogs and dogs with clinical disease involving this region. A total of 126 dogs with no clinical signs of gastrointestinal disease and six dogs with clinical diseases involving the gastroesophageal junction were included. For seven euthanized dogs, ultrasonographic features were also compared with gross pathology and histopathology. Cardial and abdominal esophageal wall thicknesses were measured ultrasonographically for all normal dogs and effects of weight, sex, age, and stomach filling were tested. Five layers could be identified in normal esophageal and cardial walls. The inner esophageal layer was echogenic, corresponding to the cornified mucosa and glandular portion of the submucosa. The cardia was characterized by a thick muscularis, and a transitional zone between echogenic esophageal and hypoechoic gastric mucosal layers. Mean (±SD) cardial wall thicknesses for normal dogs were 7.6 mm (±1.6), 9.7 mm (±1.8), 10.8 mm (±1.6), 13.3 mm (±2.5) for dogs in the <10 kg, 10-19.9 kg, 20-29.9 kg and ?30 kg weight groups, respectively. Mean (±SD) esophageal wall thicknesses were: 4.1 mm (±0.6), 5.1 mm (±1.3), 5.6 mm (±1), and 6.4 mm (±1.1) for the same weight groups, respectively. Measurements of wall thickness were significantly correlated with dog weight group. Ultrasonography assisted diagnosis in all six clinically affected dogs. Findings supported the use of transabdominal ultrasonography as a diagnostic test for dogs with suspected gastroesophageal disease. PMID:24629089

Gory, Guillaume; Rault, Delphine N; Gatel, Laure; Dally, Claire; Belli, Patrick; Couturier, Laurent; Cauvin, Eddy

2014-01-01

439

Tracheal and airway collapse in dogs.  

PubMed

Tracheal and airway collapse (bronchomalacia) are common causes of chronic cough in middle-aged to older dogs where weakening of cartilage within the respiratory system leads to narrowing of airways, coughing, wheezing, and other secondary effects. Successful treatment involves correct identification of the problem, recognition of concurrent problems, and appropriate medical therapy. Surgical and noninvasive treatment options are becoming readily available, and it is important to understand indications for such procedures. PMID:24268337

Maggiore, Ann Della

2014-01-01

440

Recurrent ossifying epulis in a dog.  

PubMed

A seven-year-old neutered/male Siberian Husky-cross dog was referred for evaluation of a gingival mass. Two years previously, the referring veterinarian had resected an ossifying epulis from the same area between the maxillary left first and second premolars. The neoplasm recurred 4-months after the original surgery. En bloc resection provided tumor-free margins. An oral examination 12-months following surgery indicated no gross signs of recurrence. PMID:12108133

Woodward, Tony M

2002-06-01

441

Top dogs: wolf domestication and wealth  

Microsoft Academic Search

A phylogeographic analysis of gene sequences important in determining body size in dogs, recently published in BMC Biology, traces the appearance of small body size to the Neolithic Middle East. This finding strengthens the association of this\\u000a event with the development of sedentary societies, and perhaps even has implications for the inception of human social inequality.\\u000a \\u000a \\u000a See research article http:\\/\\/www.biomedcentral.com\\/1741-7007\\/8\\/16\\/

Carlos A Driscoll; David W Macdonald

2010-01-01

442

Evaluation of dietary factors associated with spontaneous pancreatitis in dogs  

E-print Network

of the first five categories were included in the analysis. Ingestion of non-food items including owner medications, ethylene glycol, stuffed toys, and gloves were excluded from the definition. Data from medical records?Medical records of all dogs were... difference between the pancreatitis and renal failure dogs based on American Kennel Club group (P=0.001), with the terrier group having the most case dogs, 44 out of 64 total, followed by the toy group, 41 out of 70 (Table 3). Breeds with more than 5 dogs...

Lem, Kristina Yvonne

2009-05-15

443

Canine distemper spillover in domestic dogs from urban wildlife.  

PubMed

Canine distemper virus (CDV) causes a major disease of domestic dogs that develops as a serious systemic infection in unvaccinated or improperly vaccinated dogs. Domesticated dogs are the main reservoir of CDV, a multihost pathogen. This virus of the genus Morbillivirus in the family Paramyxoviridae occurs in other carnivorous species including all members of the Canidae and Mustelidae families and in some members of the Procyonidae, Hyaenidae, Ursidae, and Viverridae families. Canine distemper also has been reported in the Felidae family and marine mammals. The spread and incidences of CDV epidemics in dogs and wildlife here and worldwide are increasing. PMID:22041204

Kapil, Sanjay; Yeary, Teresa J

2011-11-01

444

Dogs as catalysts for social interactions: robustness of the effect.  

PubMed

It is known that pet dogs can act as catalysts for human social interactions, and it has been suggested that this may enhance feelings of well-being. Two studies were carried out to establish the robustness of this effect. In Study 1, a highly trained dog was used to ensure that the dog itself did not solicit attention from passers-by, and data were collected across a range of normal daily activities in which a dog could be included, not confined to conventional dog walking areas as in previous studies. Being accompanied by a dog increased the frequency of social interactions, especially interactions with strangers. In Study 2, also using a trained dog, a different (male) participant observer was dressed either smartly or scruffily. Although there were significantly more interactions when he was smartly dressed, the greatest effect was between the Dog present and No Dog conditions irrespective of the handler's dress. It is concluded that the social catalysis effect is very robust, which opens the way for investigating possible consequences of the effect for well-being and health. PMID:10717771

McNicholas, J; Collis, G M

2000-02-01

445

Whole genome comparison of donor and cloned dogs  

PubMed Central

Cloning is a process that produces genetically identical organisms. However, the genomic degree of genetic resemblance in clones needs to be determined. In this report, the genomes of a cloned dog and its donor were compared. Compared with a human monozygotic twin, the genome of the cloned dog showed little difference from the genome of the nuclear donor dog in terms of single nucleotide variations, chromosomal instability, and telomere lengths. These findings suggest that cloning by somatic cell nuclear transfer produced an almost identical genome. The whole genome sequence data of donor and cloned dogs can provide a resource for further investigations on epigenetic contributions in phenotypic differences. PMID:24141358

Kim, Hak-Min; Cho, Yun Sung; Kim, Hyunmin; Jho, Sungwoong; Son, Bongjun; Choi, Joung Yoon; Kim, Sangsoo; Lee, Byeong Chun; Bhak, Jong; Jang, Goo

2013-01-01

446

Segmental inertial properties in dogs determined by magnetic resonance imaging.  

PubMed

Data regarding the segmental inertial properties of the dog are currently unavailable, although such parameters are needed for dynamic analyses of canine motion. The purpose of this study was to measure the segmental inertial properties in three medium sized dogs of average build using magnetic resonance imaging. The parameters included the mass, location of centre of mass and moments of inertia for each body segment. The normalised results will serve as a preliminary foundation for various biomechanical studies in dogs, although further study is required to characterise them for specific dog breeds and to determine how they may be affected by age and gender. PMID:18691919

Amit, T; Gomberg, B R; Milgram, J; Shahar, R

2009-10-01

447

Do dogs follow behavioral cues from an unreliable human?  

PubMed

Dogs are known to consistently follow human pointing gestures. In this study, we asked whether dogs "automatically" do this or whether they flexibly adjust their behavior depending upon the reliability of the pointer, demonstrated in an immediately preceding event. We tested pet dogs in a version of the object choice task in which a piece of food was hidden in one of the two containers. In Experiment 1, Phase 1, an experimenter pointed at the baited container; the second container was empty. In Phase 2, after showing the contents of both containers to the dogs, the experimenter pointed at the empty container. In Phase 3, the procedure was exactly as in Phase 1. We compared the dogs' responses to the experimenter's pointing gestures in Phases 1 and 3. Most dogs followed pointing in Phase 1, but many fewer did so in Phase 3. In Experiment 2, dogs followed a new experimenter's pointing in Phase 3 following replication of procedures of Phases 1 and 2 in Experiment 1. This ruled out the possibility that dogs simply lost motivation to participate in the task in later phases. These results suggest that not only dogs are highly skilled at understanding human pointing gestures, but also they make inferences about the reliability of a human who presents cues and consequently modify their behavior flexibly depending on the inference. PMID:25348065

Takaoka, Akiko; Maeda, Tomomi; Hori, Yusuke; Fujita, Kazuo

2015-03-01

448

Dogs' Eavesdropping from people's reactions in third party interactions.  

PubMed

Eavesdropping involves the acquisition of information from third-party interactions, and can serve to indirectly attribute reputation to individuals. There is evidence on eavesdropping in dogs, indicating that they can develop a preference for people based on their cooperativeness towards others. In this study, we tested dogs' eavesdropping abilities one step further. In a first experiment, dogs could choose between cooperative demonstrators (the donors) who always gave food to an approaching third person (the beggar); here, the only difference between donors was whether they received positive or negative reactions from the beggar (through verbal and gestural means). Results showed that dogs preferentially approached the donor who had received positive reactions from the beggar. By contrast, two different conditions showed that neither the beggar's body gestures nor the verbal component of the interaction on their own were sufficient to affect the dogs' preferences. We also ran two further experiments to test for the possibility of dogs' choices being driven by local enhancement. When the donors switched places before the choice, dogs chose at random. Similarly, in a nonsocial condition in which donors were replaced by platforms, subjects chose at chance levels. We conclude that dogs' nonrandom choices in the present protocol relied on the simultaneous presence of multiple cues, such as the place where donors stood and several features of the beggar's behavior (gestural and verbal reactions, and eating behavior). Nonetheless, we did not find conclusive evidence that dogs discriminated the donors by their physical features, which is a prerequisite of reputation attribution. PMID:24236108

Freidin, Esteban; Putrino, Natalia; D'Orazio, María; Bentosela, Mariana

2013-01-01

449

Cutaneous metastasis of transitional cell carcinoma in 12 dogs.  

PubMed

In humans, cutaneous metastasis of transitional cell carcinoma (TCC) has been attributed to direct extension, lymphatic or hematogenous dissemination, or surgical implantation. The purpose of this study was to characterize the clinical and histologic features of cutaneous TCC metastasis, confirmed by uroplakin-III immunohistochemistry, in dogs. The 12 cases were 9 spayed female and 3 neutered male dogs, 6 to 14 years old (mean, 11 years). Four dogs had a history of urinary incontinence. Three had undergone abdominal surgery for TCC diagnosis or treatment. The primary neoplasms were 7 papillary infiltrating and 5 nonpapillary infiltrating TCC. Cutaneous lesions were detected at a mean of 123 days (median, 38 days) after diagnosis of the primary TCC and appeared as plaques, papules, or nodules in, with 1 exception, perineal, inguinal, or ventral abdominal dermis or subcutis. Of 8 dogs with dermal TCC, 5 had epidermal erosion or ulceration. In 10 dogs, TCC was detected in cutaneous lymphatic vessels, identified by endothelial immunoreactivity for Prox1. Metastases were also detected in lymph nodes in all dogs and at distant noncutaneous sites, usually the lungs, in 10 dogs. Mean survival after diagnosis was 162 days (median, 90 days). Despite medical treatment of 10 dogs after the development of cutaneous metastasis, remission was not achieved; 4 dogs had stable disease. Although TCC could have spread to skin by direct extension or lymphatic or vascular dissemination, the proximity of most cutaneous metastases to the vulva or prepuce raises the additional possibility of transepidermal spread through urine-scalded skin. PMID:23136183

Reed, L T; Knapp, D W; Miller, M A

2013-07-01

450

Diagnosis and management of ureteroceles in two female dogs.  

PubMed

Two intact female dogs were examined for refractory pollakiuria and stranguria. One of these two dogs also exhibited urinary incontinence. Ectopic ureteroceles were diagnosed via ultrasonography and cystoscopy in both dogs. Both dogs were taken to surgery for ureterocele resection and neoureterostomy, resulting in complete resolution of clinical signs. Although uncommonly reported in the veterinary literature, ectopic ureteroceles can be associated with recurrent lower urinary tract infection with and without urinary incontinence. With a correct diagnosis and appropriate treatment, prognosis for ectopic ureteroceles can be good provided there is not a concurrent significant loss of renal function. PMID:21311078

Green, Todd A; Arble, Jason B; Chew, Dennis J; Dudley, Robert M

2011-01-01

451

Testing the myth: tolerant dogs and aggressive wolves.  

PubMed

Cooperation is thought to be highly dependent on tolerance. For example, it has been suggested that dog-human cooperation has been enabled by selecting dogs for increased tolerance and reduced aggression during the course of domestication ('emotional reactivity hypothesis'). However, based on observations of social interactions among members of captive packs, a few dog-wolf comparisons found contradictory results. In this study, we compared intraspecies aggression and tolerance of dogs and wolves raised and kept under identical conditions by investigating their agonistic behaviours and cofeeding during pair-wise food competition tests, a situation that has been directly linked to cooperation. We found that in wolves, dominant and subordinate members of the dyads monopolized the food and showed agonistic behaviours to a similar extent, whereas in dogs these behaviours were privileges of the high-ranking individuals. The fact that subordinate dogs rarely challenged their higher-ranking partners suggests a steeper dominance hierarchy in dogs than in wolves. Finally, wolves as well as dogs showed only rare and weak aggression towards each other. Therefore, we suggest that wolves are sufficiently tolerant to enable wolf-wolf cooperation, which in turn might have been the basis for the evolution of dog-human cooperation (canine cooperation hypothesis). PMID:25904666

Range, Friederike; Ritter, Caroline; Virányi, Zsófia

2015-05-22

452

Toxoplasma gondii: Evidence for the transmission by semen in dogs.  

PubMed

Ten male dogs were distributed into three experimental groups for infection with Toxoplasma gondii: GI - three dogs inoculated with 2.0x10(5) P strais oocysts, GII - three dogs infected with 1.0x10(6) RH strain tachyzoites, and GIII - four controls dogs. Several clinical parameters were evaluated. IFAT was performed to detect anti-T. gondii antibodies. Presence of the parasite in semen was evaluated by PCR and bioassay techniques. Tissue parasitism was examined using bioassays and immunohistochemistry in testicle and epididymis fragments collected after orchiectomy. In semen samples collected from these two groups, the presence of T. gondii was verified by bioassays and PCR. T. gondii was detected by immunohistochemistry in tissues (testicle and epididymis fragments) of all six experimentally infected dogs. The T. gondii-positive seminal samples were used in the artificial insemination (AI) of four female dogs free of toxoplasmic infection. Seven days after AI, all of the female dogs presented serologic conversion (IFAT). Fetal reabsorption occurred in two of the dogs, while the others sustained full-term gestation. Several T. gondii cysts were detected in the brains of four offspring. These results suggest that T. gondii can be sexually transmitted in domestic dogs. PMID:19622353

Arantes, Tiago Pereira; Lopes, Welber Daniel Zanetti; Ferreira, Roberta Machado; Pieroni, Juliana S Pinto; Pinto, Vanessa M R; Sakamoto, Claudio A; Costa, Alvimar José da

2009-10-01

453

HUNT STABLE COMPLEX LOOKING NORTHWEST TOWARD DOG KENNEL RUINS ACROSS ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

HUNT STABLE COMPLEX LOOKING NORTHWEST TOWARD DOG KENNEL RUINS ACROSS THE GREAT CIRCUS - Overhills, Fort Bragg Military Reservation, Approximately 15 miles NW of Fayetteville, Overhills, Harnett County, NC

454

Importance of puppy training for future behavior of the dog.  

PubMed

In this study, we attempted to clarify whether puppy socialization and command training class, which was limited to puppies approximately 4 months of age, prevented behavior problems in dogs. We evaluated the behaviors of 142 dogs with 4 types of training experience by using a behavior test and the Canine Behavior Assessment and Research Questionnaire (C-BARQ). Dogs in the puppy class (PC) group (n=44) attended the class for 1 hr each week for 6 weeks, dogs in the puppy party (PP) group (n=39) attended a 1-hr "puppy party," dogs in the adult class (AC) group (n=27) undertook basic obedience lessons for adolescent/adult dogs for 1 hr each week for 6 weeks, and dogs in the no class (NC) group (n=32) underwent no formal training. The behavior test evaluated each dog's response to commands, owner's recall, separation, a novel stimulus and strangers. The C-BARQ evaluated 15 canine behavioral factors. The behavior test results indicated that the PC and AC groups showed significantly higher response to commands than the PP or NC group. Thus, participation in puppy and adult classes improved the obedience behavior of dogs, regardless of age. Positive response to strangers in the PC group was significantly higher than that in the AC and NC groups and tended to be higher than that in the PP group. Therefore, PC may help prevent canine behavioral problems such as disobedience or fear of strangers. PMID:23018794

Kutsumi, Ai; Nagasawa, Miho; Ohta, Mitsuaki; Ohtani, Nobuyo

2013-02-01

455

Science Sampler: You can learn a lot from your dog  

NSDL National Science Digital Library

Recently, dogs have been the focus of a great deal of scientific research. In fact, dogs were the inspiration for Professor Bruce Blumberg's class, The Cognitive Dog: Savant or Slacker, at Harvard University. This course serves as the impetus for the thematic unit presented here--You Can Learn A Lot From Your Dog. The unit incorporates cooperative learning, data analysis, and presentations while providing a powerful approach to teaching science. This unit is meaningful for middle school students as they develop an understanding of selected aspects of the inquiry process.

Sherry Worsham

2007-11-01

456

MRI findings in a dog with kernicterus.  

PubMed

A severe increase in total bilirubin coincided with a decline in neurologic status to comatose in a 9 yr old spayed female mixed-breed dog being treated for immune-mediated hemolytic anemia. MRI of the brain was performed to investigate potential causes for the neurologic signs. MRI revealed bilaterally symmetrical hyperintensities within the caudate nuclei, globus pallidus, thalamus, deep cerebellar nuclei, and cortical gray matter on T2-weighted and fluid-attenuated inversion recovery (FLAIR) sequences, which coincided with areas of bilirubin deposition and neuronal necrosis (kernicterus) identified on necropsy examination. This is the second case report of an adult dog exhibiting kernicterus, and the first report to document MRI findings associated with that condition. Kernicterus is an uncommonly reported complication of hyperbilirubinemia in dogs, but is potentially underreported due to difficulties in recognizing subtle lesions and distinguishing kernicterus from other potential causes of neurologic abnormalities with readily available antemortem tests. MRI may be helpful in supporting the diagnosis of kernicterus. PMID:23690488

Belz, Katie M; Specht, Andrew J; Johnson, Victoria S; Conway, Julia A

2013-01-01

457

Gracilis or semitendinosus myopathy in 18 dogs.  

PubMed

The clinical findings in 18 dogs with gracilis (n = 17) or semitendinosus (n = 1) myopathy are described. Each dog had a similar hind-limb gait abnormality characterized by a shortened stride with a rapid, elastic medial rotation of the paw, internal rotation of the hock and external rotation of the calcaneus [corrected] and internal rotation of the stifle during the mid-to-late swing phase of the stride. Medical management prior to or in lieu of surgery was attempted (n = 8) with no apparent response. Fifteen dogs had one or multiple surgical procedures. Although transection, partial excision, or complete resection of the affected muscle resulted in resolution of lameness following surgery, lameness recurred six weeks to five months (mean, 2.5 months; median, two months) following surgery. Adjunctive medical treatment did not prevent recurrence. Variable replacement of the affected muscle with fibrous connective tissue (predominantly along the caudolateral border of the muscle) was evident grossly, and replacement of myofibers with fibrous connective tissue was confirmed histologically. A definitive etiology could not be established. PMID:9111730

Lewis, D D; Shelton, G D; Piras, A; Dee, J F; Robins, G M; Herron, A J; Fries, C; Ginn, P E; Hulse, D A; Simpson, D L; Allen, D A

1997-01-01

458

Probable essential thrombocythemia in a dog  

SciTech Connect

Essential thrombocythemia (ET), in an 11-year-old dog was characterized by persistently high platelet counts range, 4.19 X 10(6)/microliters to 4.95 X 10(6)/microliters, abnormal platelet morphology, marked megakaryocytic hyperplasia in the bone marrow, absence of circulating megakaryoblasts, and history of splenomegaly and gastrointestinal bleeding. Increased numbers of megakaryocytes and megakaryoblasts (15% to 20%) in the bone marrow were confirmed by a positive acetylcholinesterase reaction. Another significant finding was the presence of a basophilia in blood (4,836/microliters) and bone marrow. The marked persistent thrombocytosis, absence of reactive (secondary) thrombocytosis, abnormal platelet morphology, and quantitative and qualitative changes in the megakaryocytic series in the bone marrow suggested the presence of a myeloproliferative disease. Cytochemical and ultrastructural findings aided in the diagnosis of ET. The dog was treated with radiophosphorus. The results was a rapid decline in the numbers of megakaryoblasts and megakaryocytes in the bone marrow and platelets and basophils in the peripheral blood. The dog died unexpectedly of acute necrotizing pancreatitis and diabetes mellitus before a complete remission was achieved.

Hopper, P.E.; Mandell, C.P.; Turrel, J.M.; Jain, N.C.; Tablin, F.; Zinkl, J.G.

1989-04-01

459

"Not just a dog": an attachment perspective on relationships with assistance dogs.  

PubMed

We explored individuals' relationships with an assistance dog from an attachment-theory perspective. We used both inductive and deductive thematic methods to analyze semi-structured interviews with 25 participants who had lost an assistance dog to retirement or death. Analyses revealed attachment processes of safe haven, secure base, and separation anxiety. Although attachment dynamics were an important feature of these relationships, caregiving was equally important. When confronted with the loss of their dog, almost all participants experienced intense grief. Most grief responses were consistent with the loss of a caregiving relationship. Findings suggest that grief is a natural response to the loss of a beloved companion who fulfilled fundamental needs for attachment and caregiving. PMID:21838644

Kwong, Marilyn J; Bartholomew, Kim

2011-09-01

460

Pet dog ownership decisions for parents of children with autism spectrum disorder.  

PubMed

This study aimed to examine the role of pet dogs in families of children with autism. Sixty-seven percent of families owned dogs and 94% reported that their children were bonded to their dogs. Parents described previous experience with dogs and beliefs in their benefits as influential in their dog ownership decision-making process. Children living with dogs interacted with them in play and/or sharing personal space. Sensory issues of the children impacted their interaction with dogs inside and outside the home. Time and cost of care were identified burdens of dog ownership. Benefits were the opportunity to learn responsibility and companionship. PMID:24183985

Carlisle, Gretchen K

2014-01-01

461

Methamphetamine intoxication in a dog: case report  

PubMed Central

Background Methamphetamine abuse has undergone a dramatic worldwide increase, and represents a significant and global issue for public health. Incidents of methamphetamine intoxication and death in humans are relatively commonplace. Because of its increasing illicit availability, together with legitimate use in human medicine, accidental or intentional exposure to methamphetamine in dogs is becoming a more likely scenario. Case presentation A 3-year-old, 3.7 kg intact female Miniature Poodle who had been intentionally fed an unknown amount of a crystalline-like substance developed extreme agitation, seizures, tachycardia, hyperthermia, hypertension, disseminated intravascular coagulation (DIC), bloody diarrhea, and dilated pupils. Blood work revealed leukocytosis, erythropenia, lymphocytosis, thrombocytopenia, coagulation abnormalities, but all to a mild extent, together with mild elevation in both alanine aminotranferease (ALT) and alkaline phosphatase (ALKP), and a mild decreased in glucose. Radiologic diagnosis revealed generalized, severe distension of the stomach and small intestinal tract with air. Immunochromatographic screening tests and gas chromatography mass spectrometry analysis confirmed methamphetamine intoxication and revealed concentrations of methamphetamine in blood and urine of 0.32 ?g/mL and 2.35 ?g/mL respectively. The dog demonstrated progressive improvement after supportive care, with the high fever resolved over the initial 24 hours of hospitalization, and agitation was successfully controlled beyond 48 hours after initial hospitalization. Hemostatic abnormalities were progressive improved after heparin therapy and supportive care. By the sixth day of hospitalization the dog was clinically well, and all laboratory data had returned to normal with the exception of a mild elevateion of ALKP. Conclusion To the authors’ knowledge, this is the second case report of methamphetamine intoxication in dogs presented in veterinary practice in open literature so far. Although rare, methamphetamine intoxication should be considered as a differential diagnosis in dogs with a toxic substance ingestion history and with typical nervous and cardiovascular system symptoms. In such cases rapid diagnosis and aggressive intervention is important for prognosis. Blood methamphetamine concentration may be a helpful value for assessment of the severity of intoxication and prediction of clinical outcomes. PMID:24962469

2014-01-01

462

Craniomandibular Trauma and Tooth Loss in Northern Dogs and Wolves: Implications for the Archaeological Study of Dog Husbandry and Domestication  

PubMed Central

Archaeological dog remains from many areas clearly show that these animals suffered tooth fractures, tooth loss, trauma, and dental defects during their lives. Relatively little research has explored the meanings of these patterns, particularly for ancient dog remains from small-scale societies of the North. One limiting issue is the lack of comparative data on dental health and experiences of trauma among northern wolves and dogs. This paper examines tooth loss, tooth fracture, enamel hypoplasia, and cranial trauma in a large sample of historic dog and wolf remains from North America and Northern Russia. The data indicate that the dogs more commonly experienced tooth loss and tooth fracture than the wolves, despite reportedly being fed mostly soft foods such as blubber and fish. The higher rates observed in the dogs likely is a result of food stress and self-provisioning through scavenging. The ability to self-provision was likely important for the long-term history of dog use in the north. Dogs also more commonly experienced cranial fractures than wolves, particularly depression fractures on their frontal bones, which were likely the result of blows from humans. Hypoplastic lesions are rare in both wolves and dogs, and probably result from multiple causes, including food stress, disease, and trauma. PMID:24941003

Losey, Robert J.; Jessup, Erin; Nomokonova, Tatiana; Sablin, Mikhail

2014-01-01

463

Selected gelling agents in canned dog food affect nutrient digestibilities and fecal characteristics of ileal cannulated dogs.  

PubMed

Little is known about the effects of gelling agents in canned dog food on nutrient digestibilities and fecal characteristics. Dogs were fed canned diets with either no gelling agent (control) or one of three gelling agents, wheat starch, a guar gum/carrageenan mixture (50:50), and a locust bean meal (LBM)/carrageenan mixture (50:50) incorporated at two levels (0.2 and 0.5% of the diet on a wet weight basis). Six dogs were fed each diet in a 6 x 7 Youden square design. Dogs fed diets containing gelling agents had higher ileal digestibilities of OM (P = 0.05), fat (P < 0.01), GE (P = 0.02), and total amino acids (P = 0.04) and lower (P < 0.01) total tract DM digestibilities when compared to dogs fed the control diet. Fecal output by dogs fed the control diet, expressed on both an as-is (73.4 g/d) and DM (45.6 g/d) basis, was lower (P < 0.01) than for dogs fed gelling agent-containing diets (mean 102.3 g/d as-is and 57.6 g/d DM). Dogs fed the control diet also had lower (P < 0.01) fecal DM percentages and higher (P = 0.02) fecal scores than dogs fed gelling agent-containing diets. PMID:12389228

Karr-Lilienthal, Lisa K; Merchen, N R; Grieshop, Christine M; Smeets-Peeters, Marianne J E; Fahey, G C

2002-04-01

464

Mechanisms of capsaicin- and lactic acid-induced bronchoconstriction in the newborn dog  

PubMed Central

Capsaicin activation of the pulmonary C fibre vanilloid receptor (VR1) evokes the pulmonary chemoreflex and reflex bronchoconstriction. Among potential endogenous ligands of C fibre afferents, lactic acid has been suggested as a promising candidate. We tested the hypotheses that (a) lactic acid behaves as a stimulant of C fibre receptors in the newborn dog to cause reflex bronchoconstriction, and (b) lactic acid causes reflex bronchoconstriction via the same pulmonary C fibre receptor mechanism as capsaicin using the competitive capsaicin/VR1 receptor antagonist capsazepine. Right heart injection of lactic acid caused a significant increase (47 ± 8.0%) in lung resistance (RL) that was atropine sensitive (reduced by 75%; P < 0.05), consistent with reflex activation of muscarinic efferents by stimulation of C fibre afferents. Infusion of the competitive capsaicin antagonist capsazepine caused an 80% reduction (P < 0.01) in the control bronchoconstrictor response (41 ± 8.5% increase in RL) to right heart injections of capsaicin. The effects of capsazepine are consistent with reversible blockade of the VR1 receptor to abolish C fibre-mediated reflex bronchoconstriction. Lactic acid-evoked increases in RL were unaffected by VR1 blockade with capsazepine, consistent with a separate lactic acid-induced reflex mechanism. We conclude that (a) putative stimulation of C fibres with lactic acid causes reflex bronchoconstriction in the newborn dog, (b) capsazepine reversibly antagonizes reflex bronchoconstriction elicited by right heart injection of capsaicin, presumably by attenuating capsaicin-induced activation of the C fibre ‘capsaicin’ receptor (VR1), and (c) capsazepine resistance of lactic acid-induced bronchoconstriction indicates that lactic acid evokes reflex bronchoconstriction by a separate mechanism, possibly via the acid-sensing ionic channel. PMID:10050022

Nault, M A; Vincent, S G; Fisher, J T

1999-01-01

465

Energy requirements of adult dogs: a meta-analysis.  

PubMed

A meta-analysis was conducted to determine the maintenance energy requirements of adult dogs. Suitable publications were first identified, and then used to generate relationships amongst energy requirements, husbandry, activity level, methodology, sex, neuter status, dog size, and age in healthy adult dogs. Allometric equations for maintenance energy requirements were determined using log-log linear regression. So that the resulting equations could readily be compared with equations reported by the National Research Council, maintenance energy requirements in the current study were determined in kcal/kg(0.75) body weight (BW). Ultimately, the data of 70 treatment groups from 29 publications were used, and mean (± standard deviation) maintenance energy requirements were 142.8±55.3 kcal·kgBW(-0.75)·day(-1). The corresponding allometric equation was 81.5 kcal·kgBW(-0.9)·day(-1) (adjusted R2?=?0.64; 70 treatment groups). Type of husbandry had a significant effect on maintenance energy requirements (P<0.001): requirements were greatest in racing dogs, followed by working dogs and hunting dogs, whilst the energy requirements of pet dogs and kennel dogs were least. Maintenance energy requirements were less in neutered compared with sexually intact dogs (P<0.001), but there was no effect of sex. Further, reported activity level tended to effect the maintenance energy requirement of the dog (P?=?0.09). This review suggests that estimating maintenance energy requirements based on BW alone may not be accurate, but that predictions that factor in husbandry, neuter status and, possibly, activity level might be superior. Additionally, more information on the nutrient requirements of older dogs, and those at the extremes of body size (i.e. giant and toy breeds) is needed. PMID:25313818

Bermingham, Emma N; Thomas, David G; Cave, Nicholas J; Morris, Penelope J; Butterwick, Richard F; German, Alexander J

2014-01-01

466

Rethinking dog domestication by integrating genetics, archeology, and biogeography  

PubMed Central

The dog was the first domesticated animal but it remains uncertain when the domestication process began and whether it occurred just once or multiple times across the Northern Hemisphere. To ascertain the value of modern genetic data to elucidate the origins of dog domestication, we analyzed 49,024 autosomal SNPs in 1,375 dogs (representing 35 breeds) and 19 wolves. After combining our data with previously published data, we contrasted the genetic signatures of 121 breeds with a worldwide archeological assessment of the earliest dog remains. Correlating the earliest archeological dogs with the geographic locations of 14 so-called “ancient” breeds (defined by their genetic differentiation) resulted in a counterintuitive pattern. First, none of the ancient breeds derive from regions where the oldest archeological remains have been found. Second, three of the ancient breeds (Basenjis, Dingoes, and New Guinea Singing Dogs) come from regions outside the natural range of Canis lupus (the dog’s wild ancestor) and where dogs were introduced more than 10,000 y after domestication. These results demonstrate that the unifying characteristic among all genetically distinct so-called ancient breeds is a lack of recent admixture with other breeds likely facilitated by geographic and cultural isolation. Furthermore, these genetically distinct ancient breeds only appear so because of their relative isolation, suggesting that studies of modern breeds have yet to shed light on dog origins. We conclude by assessing the limitations of past studies and how next-generation sequencing of modern and ancient individuals may unravel the history of dog domestication. PMID:22615366

Larson, Greger; Karlsson, Elinor K.; Perri, Angela; Webster, Matthew T.; Ho, Simon Y. W.; Peters, Joris; Stahl, Peter W.; Piper, Philip J.; Lingaas, Frode; Fredholm, Merete; Comstock, Kenine E.; Modiano, Jaime F.; Schelling, Claude; Agoulnik, Alexander I.; Leegwater, Peter A.; Dobney, Keith; Vigne, Jean-Denis; Vilŕ, Carles; Andersson, Leif; Lindblad-Toh, Kerstin

2012-01-01

467

Energy Requirements of Adult Dogs: A Meta-Analysis  

PubMed Central

A meta-analysis was conducted to determine the maintenance energy requirements of adult dogs. Suitable publications were first identified, and then used to generate relationships amongst energy requirements, husbandry, activity level, methodology, sex, neuter status, dog size, and age in healthy adult dogs. Allometric equations for maintenance energy requirements were determined using log-log linear regression. So that the resulting equations could readily be compared with equations reported by the National Research Council, maintenance energy requirements in the current study were determined in kcal/kg0.75 body weight (BW). Ultimately, the data of 70 treatment groups from 29 publications were used, and mean (± standard deviation) maintenance energy requirements were 142.8±55.3 kcal.kgBW?0.75.day?1. The corresponding allometric equation was 81.5 kcal.kgBW?0.93.day?1 (adjusted R2?=?0.64; 70 treatment groups). Type of husbandry had a significant effect on maintenance energy requirements (P<0.001): requirements were greatest in racing dogs, followed by working dogs and hunting dogs, whilst the energy requirements of pet dogs and kennel dogs were least. Maintenance energy requirements were less in neutered compared with sexually intact dogs (P<0.001), but there was no effect of sex. Further, reported activity level tended to effect the maintenance energy requirement of the dog (P?=?0.09). This review suggests that estimating maintenance energy requirements based on BW alone may not be accurate, but that predictions that factor in husbandry, neuter status and, possibly, activity level might be superior. Additionally, more information on the nutrient requirements of older dogs, and those at the extremes of body size (i.e. giant and toy breeds) is needed. PMID:25313818

Bermingham, Emma N.; Thomas, David G.; Cave, Nicholas J.; Morris, Penelope J.; Butterwick, Richard F.; German, Alexander J.

2014-01-01

468

Who let the dogs out? Infection control did: utility of dogs in health care settings and infection control aspects.  

PubMed

Research has substantiated that animals improve human health, both psychologically and physiologically. Therefore, healthcare facilities have begun to implement programs, such as the "Furry Friends Foundation," that bring animals into the facility to improve the quality of life of patients. When implementing these programs, consideration must be given to potential adverse events such as phobias, allergies, and particularly the possibility of zoonotic disease transmission. Santa Clara Valley Medical Centre (SCVMC), a 600-bed county teaching hospital with specialized units (e.g., for burns, rehabilitation, and pediatric care), has implemented programs that incorporate animals into the healthcare setting. This facility allows three categories of dogs to interact with their patients: service dogs, therapy dogs, and pet visitation dogs by the "Furry Friends Foundation." A blurring of the roles of the three categories of dogs occurred when these programs were put into place at SCVMC. The American with Disabilities Act (ADA) states that service animals cannot be prohibited from any area. For example, a "no pet allowed" policy could not apply to these animals. Proof of a person's disability or proof of the service animal's health or training cannot be required. The purpose of this project was to maintain these programs by clarifying the policies regarding animals, specifically dogs, in the healthcare setting. This had to take place to provide a safe and enjoyable environment for the patients and the staff. A comprehensive table was developed to delineate the three categories of dogs and the corresponding policies. Therapy dogs and the visitation animals are more restricted than service dogs. Both therapy dogs and visitation dogs require identification and certification of health and are excluded from certain areas of the facility, including intensive care units and isolation rooms. By complying with the current policies and regulations, the risks from these programs can be minimized. Staff should be educated on the proper terminology and procedures to prevent a blurring of the categories and roles of these animals. PMID:16765210

DiSalvo, Heidi; Haiduven, Donna; Johnson, Nancy; Reyes, Valentine V; Hench, Carmen P; Shaw, Rosemary; Stevens, David A

2006-06-01

469

Managing Dog Waste: Campaign Insights from the Health Belief Model  

ERIC Educational Resources Information Center

Aiming to help municipalities develop effective education and outreach campaigns to reduce stormwater pollutants, such as pet waste, this study applied the Health Belief Model (HBM) to identify perceptions of dog waste and corresponding collection behaviors from dog owners living in a small U.S. city. Results of 455 online survey responses…

Typhina, Eli; Yan, Changmin

2014-01-01

470

ARE LIVESTOCK GAINS AFFECTED BY BLACKTAILED PRAIRIE DOGS?  

Technology Transfer Automated Retrieval System (TEKTRAN)

There is little empirical data addressing the important and controversial question of the effect of prairie dogs (Cynomys spp.) in western rangelands on livestock gains. This is particularly relevant in the shortgrass steppe where the area colonized by prairie dogs has increased substantially exace...

471

Sit, Stay, Read: Improving Literacy Skills Using Dogs!  

ERIC Educational Resources Information Center

While the idea of using a dog in the classroom at first seems unorthodox, the history of using animals in therapeutic settings is extensive. The first documented use of animals in a therapeutic setting was in a mental institution in England in 1792 (Levinson, 1969). In North America, dogs were first used in therapy in 1919 at St. Elizabeth's…

Pillow-Price, Kathy; Yonts, Nikki; Stinson, Laura

2014-01-01

472

Plasma-cortisol levels in experimental heatstroke in dogs  

NASA Astrophysics Data System (ADS)

The effect of external heat-load, exercise and dehydration on dynamic changes in plasma cortisol during the development of heatstroke was investigated. Thirty-three unanesthetized dogs were tested under two sets of climatic conditions: comfort conditions and hot-dry climatic conditions, half of them while exercising. Half of the dogs in each group were rehydrated. None of the dogs that were investigated at room temperature suffered heatstroke. Of the dogs exposed to high ambient temperature, all of the exercising, as well as five out of six non-hydrated dogs and one rehydrated non-exercising dog suffered heatstroke. Significant dehydration (6% 7% of body weight), occurred only under hgh ambient temperature. Plasma cortisol levels of all dogs that suffered heatstroke rose conspicuously for at least 5 h and returned to normal levels 24 h later. Cortisol levels of dogs who did not experience heatstroke remained within the normal range. Cortisol levels correlated with the severity of the stress leading to heatstroke. High and rising levels of cortisol, several hours after body temperature returns to normal, may support the diagnosis of heatstroke.

Assia, Ehud; Epstein, Yoram; Magazanik, Avraham; Shapiro, Yair; Sohar, Ezra

1989-06-01

473

O1 Dog Pack revising mental models creating mental models  

E-print Network

dogs, which show body language related to sharing space. When you make your choice, consider whether seeking to better understand reality ASK QUESTIONS MEASUREMENTS Nature's Partners: predators, prey & you observation (fact) and inference (interpretation) when folk psychology influences our understanding of dog

Packard, Jane M.

474

Behavioural correlation of heart rate changes in family dogs  

Microsoft Academic Search

Fourteen dogs (7 males and 7 females) were tested for their heart rate (HR) and heart rate variability (HRV) responses in different activities and environmental challenges while their movement was controlled. First, we wanted to compare the dogs’ cardiac responses in different body positions (lying, sitting and standing) and during slow walking to reveal their possible influence on HR and

Katalin Maros; Antal Dóka; Ádám Miklósi

2008-01-01

475

Association between dog guardianship and HIV clinical outcomes  

PubMed Central

Despite numerous potential health outcomes of dog guardianship, their value has not been examined in the HIV-positive population. The study objective was to examine the relationship between dog guardianship and HIV clinical outcomes (antiretroviral adherence [?95% versus <95%], HIV viral load [?48copies/mL versus <48copies/mL], and CD4+ cell count) among HIV-positive individuals. We conducted a secondary analysis of baseline data of 370 HIV-positive men on antiretrovirals enrolled in the Duo Project. Generalized estimating equations were used for inferential regression analyses, while controlling for the focal dog guardianship variable and non-focal covariates. Current dog guardianship was reported in 28.7% of participants. Dog guardianship may be associated with higher CD4+ (coefficient=60.6, p=0.052) and adherence ?95% (OR=1.80, p=0.048); however, having a detectable viral load was not related to dog guardianship (OR=0.94, p=0.85). Further clinical research with detailed dog guardianship data is needed to further examine the association between dog guardianship and HIV clinical outcomes. PMID:25436253

Saberi, Parya; Neilands, Torsten B.; Johnson, Mallory O.

2014-01-01

476

Comparison of different bronchial closure techniques following pneumonectomy in dogs  

Microsoft Academic Search

The comparison of the histologic healing and broncho- pleural fistula (BPF) complications encountered with three different BS closure techniques (manual suture, sta- pler and manual suture plus tissue flab) after pneumo- nectomy in dogs was investigated for a one-month period. The dogs were separated into two groups: group I (GI) (n = 9) and group II (GII) (n = 9).

Hakan Salci; A. Sami Bayram; Ozgur Ozyigit; Cengiz Gebitekin; O. Sacit Gorgul

2007-01-01

477

Granulocytic anaplasmosis in three dogs from Saskatoon, Saskatchewan  

PubMed Central

Three dogs from Saskatoon, Saskatchewan were diagnosed with acute granulocytic anaplasmosis. Fever, lethargy, inappetence, vomiting, diarrhea, and lameness were reported. Lymphopenia, thrombocytopenia, and splenomegaly were identified in all dogs. Inclusions were identified within the cytoplasm of blood neutrophils, and infection with Anaplasma phagocytophilum was confirmed by polymerase chain reaction. PMID:19881921

Cockwill, Ken R.; Taylor, Susan M.; Snead, Elisabeth C.R.; Dickinson, Ryan; Cosford, Kevin; Malek, Sarah; Lindsay, L. Robbin; de Paiva Diniz, Pedro Paulo Vissotto

2009-01-01

478

Leishmania (Viannia) Infection in the Domestic Dog in Chaparral, Colombia  

PubMed Central

Peridomestic transmission of American cutaneous leishmaniasis is increasingly reported and dogs may be a reservoir of Leishmania (Viannia) in this setting. We investigated the prevalence of infection in dogs in Chaparral County, Colombia, the focus of an epidemic of human cutaneous leishmaniasis caused by Leishmania (Viannia) guyanensis. Two (0.72%) of 279 dogs had lesions typical of cutaneous leishmaniasis that were biopsy positive by kinetoplast DNA polymerase chain reaction–Southern blotting. Seroprevalence was 2.2% (6 of 279) by enzyme-linked immunosorbent assay. Buffy coat and ear skin biopsy specimens were positive by polymerase chain reaction–Southern blotting in 7.3% (10 of 137) and 11.4% (12 of 105) of dogs, respectively. Overall 20% of dogs (21 of 105) showed positive results for one or more tests. Amplification and sequencing of the Leishmania 7SL RNA gene identified L. guyanensis in one dog and L. braziliensis in two dogs. No association was identified between the risk factors evaluated and canine infection. Dogs may contribute to transmission but their role in this focus appears to be limited. PMID:21540374

Santaella, Julián; Ocampo, Clara B.; Saravia, Nancy G.; Méndez, Fabián; Góngora, Rafael; Gomez, Maria Adelaida; Munstermann, Leonard E.; Quinnell, Rupert J.

2011-01-01

479

Acute phase response in dogs with Dirofilaria immitis.  

PubMed

The aim of this study was to determine concentrations of different positive and negative acute phase proteins (C-reactive protein, haptoglobin, albumin and paraoxonase-1) in dogs naturally infected with Dirofilaria immitis at the time of diagnosis. 194 dogs were included in the study. All were evaluated for the presence or absence of D. immitis circulating antigens and for the presence or absence of microfilariae and a clinical examination was carried out. 38 dogs were negative and 156 dogs were positive for circulating D. immitis antigens. A significant increase in C-reactive protein and significant decreases in albumin and paraoxonase-1 activity were observed in positive dogs. These changes appeared with independence of the presence/absence of microfilariae or clinical signs. C-reactive protein was the only acute phase protein that showed significant differences between asymptomatic and symptomatic dogs. Interestingly, the increases seen in C-reactive protein values were not accompanied by increases in haptoglobin, and haptoglobin even decreased in the dogs with microfilaria. This could be due to the hemolytic anemia which can be produced in dirofilariasis. In conclusion, there is an acute phase response (with increases in C-reactive protein and decreases in albumin and paraoxonase-1) and a divergence in the behaviour between C-reactive protein and haptoglobin in dogs with D. immitis. PMID:24893697

Méndez, J C; Carretón, E; Martínez, S; Tvarijonaviciute, A; Cerón, J J; Montoya-Alonso, J A

2014-08-29

480

Superficial necrolytic dermatitis (necrolytic migratory erythema) in dogs.  

PubMed

Twenty-two dogs with superficial necrolytic dermatitis were evaluated prospectively, twenty-one of which had characteristic crusting lesions of the paw pads. Histologically, epidermal lesions included parakeratosis and laminar intracellular edema. The plasma amino acid concentrations of eight dogs were markedly depressed. Nine dogs had terminal diabetes mellitus. These clinical and morphologic findings were strikingly similar to those of necrolytic migratory erythema in human beings, the most common cause of which is hyperglucagonemia due to islet cell tumor of the pancreas. No pancreatic tumors were found in these dogs; plasma glucagon concentrations in the five dogs tested were normal. The serum alkaline phosphatase concentrations were elevated in all dogs. Severe vacuolar hepatopathy, suggesting metabolically or hormonally induced hepatic dysfunction, was found in 21 dogs at necropsy or by biopsy; one dog had ultrasonographic abnormalities of the liver. Histopathologically, severe vacuolar alteration resulted in parenchymal collapse and nodular regeneration, which grossly mimicked cirrhosis. Although the definitive metabolic stimulus was not discovered for the cutaneous and hepatic lesions, the similarity of the cutaneous and biochemical features of canine superficial necrolytic dermatitis to human necrolytic migratory erythema warrants further investigation into possible underlying pancreatic hormonal dysfunction. PMID:8442331

Gross, T L; Song, M D; Havel, P J; Ihrke, P J

1993-01-01

481

Association between dog guardianship and HIV clinical outcomes.  

PubMed

Despite numerous potential health outcomes of dog guardianship, their value has not been examined in the HIV-positive population. The study objective was to examine the relationship between dog guardianship and HIV clinical outcomes (antiretroviral adherence [>95% versus <95%], HIV viral load [> or =48 versus <48 copies/mL], and CD4 count) among HIV-positive individuals. The authors conducted a secondary analysis of baseline data of 370 HIV-positive men on antiretroviral regimen enrolled in the Duo Project. Generalized estimating equations were used for inferential regression analyses, while controlling for the focal dog guar- dianship variable and nonfocal covariates. Current dog guardianship was reported in 28.7% of participants. Dog guardianship may be associated with higher CD4 (coefficient = 60.6, P = .052) and adherence >95% (odds ratio [OR] = 1.80, P = .048); however, having a detectable viral load was not related to dog guardianship (OR = 0.94, P = .85). Further clinical research with detailed dog guardianship data is needed to further examine the association between dog guardianship and HIV clinical outcomes. PMID:25436253

Saberi, Parya; Neilands, Torsten B; Johnson, Mallory O

2014-01-01

482

Association between dog guardianship and HIV clinical outcomes.  

PubMed

Despite numerous potential health outcomes of dog guardianship, their value has not been examined in the HIV-positive population. The study objective was to examine the relationship between dog guardianship and HIV clinical outcomes (antiretroviral adherence [>95% versus <95%], HIV viral load [> or =48 versus <48 copies/mL], and CD4 count) among HIV-positive individuals. The authors conducted a secondary analysis of baseline data of 370 HIV-positive men on antiretroviral regimen enrolled in the Duo Project. Generalized estimating equations were used for inferential regression analyses, while controlling for the focal dog guar- dianship variable and nonfocal covariates. Current dog guardianship was reported in 28.7% of participants. Dog guardianship may be associated with higher CD4 (coefficient = 60.6, P = .052) and adherence >95% (odds ratio [OR] = 1.80, P = .048); however, having a detectable viral load was not related to dog guardianship (OR = 0.94, P = .85). Further clinical research with detailed dog guardianship data is needed to further examine the association between dog guardianship and HIV clinical outcomes. PMID:25513022

Saberi, Parya; Neilands, Torsten B; Johnson, Mallory O

2014-01-01

483

Subcutaneous Mycoleptodiscus indicus Infection in an Immunosuppressed Dog ?  

PubMed Central

An 8-year-old dog presented with several dermal excoriations. Lesion cytology revealed pyogranulomatous inflammation with branching, septate hyphae. A mold identified as Mycoleptodiscus indicus by morphology and sequencing was cultured from fine-needle aspirates. This is the first report of a Mycoleptodiscus species as an etiologic agent in a dog. PMID:20519473

Metry, Catherine A.; Hoien-Dalen, Patricia S.; Maddox, Carol W.; Thompson, Elizabeth H.; Sutton, Deanna A.; Romanelli, Anna M.; Wickes, Brian L.; MacNeill, Amy L.

2010-01-01

484

Tissue responses of calcium phosphate cement: a study in dogs  

Microsoft Academic Search

The in vivo properties of a new kind of calcium phosphate cement were investigated in this study. Calcium phosphate cement was implanted as paste into femoral bone and dorsal muscle of dogs for 3 and 6 months, and as prehardened form into thigh muscles of dogs for 1, 2 and 6 months. Histology was performed on thin un-decalcified sections. No

Huipin Yuan; Yubao Li; JD de Bruijn; K de Groot; Xingdong Zhang

2000-01-01

485

Vaccine-Laden Bait Beside a Prairie Dog Burrow  

USGS Multimedia Gallery

Over 30 organizations and agencies are testing a USGS-developed oral vaccine to prevent the spread of plague in prairie dogs. If successful, the sylvatic plague vaccine could help protect endangered black-footed ferrets in the western U.S. because the ferrets rely on prairie dogs for ...

486

Effects of prairie dogs on livestock gains in shortgrass steppe  

Technology Transfer Automated Retrieval System (TEKTRAN)

There are few empirical data addressing the important and controversial question of the effects of prairie dogs (Cynomys spp.) on livestock weight gains in western rangelands. This is particularly relevant in the shortgrass steppe where the area occupied by prairie dogs has increased substantially i...

487

Platelet function in dogs with congenital portosystemic shunt  

Microsoft Academic Search

The aim of this study was to examine the influence of congenital portosystemic shunts (CPSS) on primary haemostasis in dogs. Bleeding time, automated platelet function analysis (PFA 100 analyser), platelet count and platelet aggregation using different methods and agonists were measured in 10 dogs with untreated CPSS and in 10 healthy, age-matched controls.Bleeding time, platelet function analysis and platelet counts

K. Kalbantner; A. Meyer-Lindenberg; R. Mischke

2011-01-01

488

SEROPREVALENCE OF NEOSPORA CANINUM ANTIBODIES IN DOGS IN INDIA  

Technology Transfer Automated Retrieval System (TEKTRAN)

Neospora caninum is one of most important causes of abortion in cattle worldwide and dogs are an important risk factor for N. caninum infection in cattle. Antibodies to N. caninum were determined in 184 (126 rural, 58 urban) dogs from the Punjab State, India, by a commercial monoclonal antibody bas...

489

Medical management of a patent ductus venosus in a dog  

PubMed Central

Abstract A 2.5-year-old dog with signs of weight loss, vomiting, and hepatic encephalopathy was diagnosed with a patent ductus venosus, based on serum biochemical analysis, jejunal portography, and biopsies, and treated with lactulose, antibiotics, and a reduced protein diet. Two years after initial presentation, the dog is still being managed medically. PMID:15943124

2005-01-01

490

The dog as model for chemotherapy of the Chagas’ disease  

Microsoft Academic Search

In the present study, we investigated the role of dogs as experimental models for acute and chronic phases of Chagas’ disease, before and after therapeutic treatments. Dogs were infected with Trypanosoma cruzi strains of different susceptibilities to benznidazole (Bz) and treated with the same therapeutic scheme as used for human chagasic. The treatment with Bz was able to prevent death

Paulo Marcos da Matta Guedes; Vanja Maria Veloso; Washington Luiz Tafuri; Lúcia Maria da Cunha Galvăo; Cláudia Martins Carneiro; Marta de Lana; Egler Chiari; Killarney Ataide Soares; Maria Terezinha Bahia

2002-01-01

491

The domestic dog: man's best friend in the genomic era  

PubMed Central

The domestic dog genome - shaped by domestication, adaptation to human-dominated environments and artificial selection - encodes tremendous phenotypic diversity. Recent developments have improved our understanding of the genetics underlying this diversity, unleashing the dog as an important model organism for complex-trait analysis. PMID:21338479

2011-01-01

492

Translation of new cancer treatments from pet dogs to humans  

Microsoft Academic Search

Naturally occurring cancers in pet dogs and humans share many features, including histological appearance, tumour genetics, molecular targets, biological behaviour and response to conventional therapies. Studying dogs with cancer is likely to provide a valuable perspective that is distinct from that generated by the study of human or rodent cancers alone. The value of this opportunity has been increasingly recognized

Melissa Paoloni; Chand Khanna

2008-01-01

493

Toxoplasmosis and other intestinal coccidial infections in cats and dogs  

Technology Transfer Automated Retrieval System (TEKTRAN)

Much needs to be learned concerning the pathogenesis of clinical coccidiosis in dogs. Why does coccidiosis occurs after shipping, and nothing is known of biologic differences among isolates of Isospora species of dogs and cats. Transmission of Isospora felis in cats in breeding colonies despite of s...

494

Clinical, histological and cytogenetic observations on nine intersex dogs  

E-print Network

Clinical, histological and cytogenetic observations on nine intersex dogs S Chaffaux1 EP Cribiu2 1 / dogs / cytogenetics / histology INTRODUCTION Alterations in the normal differentiation patterns. Histological sections were stained with hematoxylin-eosin. CASE REPORTS Out of nine animals, four (1-4) had

Boyer, Edmond

495

Do dogs harbour risk factors for human breast cancer?  

Microsoft Academic Search

Summary We ask consulting patients regularly whether they keep pets in order to identify zoonotic factors. It became apparent that patients with breast carcinoma (N = 69) owned significantly more often dogs but not cats compared to age matched female controls. We compared the frequencies of dog and pet ownership with data from public available statistics on women (N =

B. Laumbacher; B. Fellerhoff; B. Herzberger; R. Wank

2006-01-01

496

Anaplasma platys in Bone Marrow Megakaryocytes of Young Dogs  

PubMed Central

Anaplasma platys is an obligate intracellular rickettsial pathogen that infects platelets of dogs, forming basophilic intracellular morulae. In the present report, cellular inclusions were documented in bone marrow thrombocyte precursors of two young naturally infected dogs, indicating that A. platys can infect megakaryocytes and promegakaryocytes. PMID:24622106

De Tommasi, A. Sara; Baneth, Gad; Breitschwerdt, Edward B.; Stanneck, Dorothee; Dantas-Torres, Filipe; Otranto, Domenico

2014-01-01

497

Dog ownership and contact during childhood and later allergy development  

Microsoft Academic Search

The effect of dog ownership during childhood on the development of allergy has been investigated in few studies with conflicting results. The association between dog contact and indoor endotoxin exposure during infancy and the development of allergic sensitisation and atopic disease up to age 6 yrs was investigated. Two ongoing birth cohorts, the German Infant Nutrition