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EPA Science Inventory

The reproductive rhythmicity of the false grunion, Colpichthys regis, was observed in the Estero del Soldado, Mexico during October 1982 through January 1983. Spawning runs occurred at approximately 2-week intervals during daytime high tides. These high tides coincided with new a...



Microsoft Academic Search

The decapod crustacean community in Estero El Verde, Camacho, Sinaloa included 31 species, 17 genera and 12 families. The genus Uca (Ocypodidae) was the most common. The swimming crabs Callinectes arcuatus and C. toxotes and the shrimp Litopenaeus vannamei, L. stylirostris and Farfantepenaeus californiensis were particularly notable among the commercial species. Macrobrachium tenellum and Gecarcinus planatus might represent alternatives for

JF Arzola-González; LM Flores-Campaña


Probability of transmission of Chagas disease by Triatoma infestans (Hemiptera: Reduviidae) in an endemic area of Santiago del Estero, Argentina.  

PubMed Central

The daily probability (P) of transmission of Trypanosoma cruzi to a noninfected human host by an infected Triatoma infestans bug was estimated using field data from a 2-year longitudinal study carried out in a rural settlement of 20 households in Amamá, Santiago del Estero, Argentina. The following information was used for this purpose: the bug density and the proportion of infected bugs; the bug biting rate and the distribution of bites between humans and animals; the age-specific seropositivity to T. cruzi of the human population; and the actual number of new cases of human infection. The 2-year accumulated number of infective contacts per house estimated using a binomial model shows a statistically significant logistic correlation with the observed proportion of new cases per house. An average house where new cases of human infection were registered in the 2-year period had a P value of 0.0012, while an average general house (i.e., with and without new cases) had a P value of 0.0009. The observed range of P is discussed in terms of the chain of factors that affects the individual human risk of acquiring the infection and the possible entomological sampling errors.

Rabinovich, J. E.; Wisnivesky-Colli, C.; Solarz, N. D.; Gurtler, R. E.



33 CFR 80.1132 - Estero-Morro Bay, CA.  

Code of Federal Regulations, 2013 CFR

...2013-07-01 2013-07-01 false Estero-Morro Bay, CA. 80.1132 Section 80.1132 Navigation and Navigable Waters...DEMARCATION LINES Pacific Coast § 80.1132 Estero-Morro Bay, CA. A line drawn from the seaward extremity of the Morro...



Bathymetry and acoustic backscatter: Estero Bay, California  

USGS Publications Warehouse

Between July 30 and August 9, 2012, scientists from the U.S. Geological Survey (USGS), Pacific Coastal and Marine Science Center (PCMSC), acquired bathymetry and acoustic-backscatter data from Estero Bay, San Luis Obispo, California, under PCMSC Field Activity ID S-05-12-SC. The survey was done using the R/V Parke Snavely outfitted with a multibeam sonar for swath mapping and highly accurate position and orientation equipment for georeferencing. This report provides these data in a number of different formats, as well as a summary of the mapping mission, maps of bathymetry and backscatter, and Federal Geographic Data Committee (FGDC) metadata.

Hartwell, Stephen R.; Finlayson, David P.; Dartnell, Peter; Johnson, Samuel Y.



Shellfish Mariculture in Drakes Estero, Point Reyes National Seashore, California.  

National Technical Information Service (NTIS)

When Drakes Estero, which lies within the Point Reyes National Seashore (PRNS) about 25 miles northwest of San Francisco, California, was designated by Congress in 1976 as Potential Wilderness, it contained a commercial shellfish (nonnative oyster and cla...




Microsoft Academic Search

The flora and the aquatic vegetation of lake Cuitzeo are described. The wide extension of the lake, its shallowness and its numerous springs, determine a great diversity of habitats which allow the development of different aquatic and subaquatic life forms. There is an amazing floristic richness represented by 40 families, 70 genera and 92 species, of which 25 are strictly



Shorebird Use of Estero Santa Cruz, Sonora, México: Abundance, Diversity and Conservation Implications  

Microsoft Academic Search

Ground-based censuses of shorebirds were conducted during the winters of 2000-2008 (even years only) and the springs of 2002-2004 and 2008 at Estero Santa Cruz, Sonora, México, a 3,622 ha coastal wetland at the Gulf of California between the Colorado River Delta and Bahía Santa Maria and Ensenada Pabellones, Sinaloa. We documented 21 shorebird species using Estero Santa Cruz. Winter

Thomas L. Fleischner; H. River Gates



Hydrodynamic Characteristics and Salinity Patterns in Estero Bay, Lee County, Florida  

USGS Publications Warehouse

Estero Bay is an estuary (about 12 miles long and 3 miles wide) on the southwestern Florida coast, with several inlets connecting the bay to the Gulf of Mexico and numerous freshwater tributaries. Continuous stage and salinity data were recorded at eight gaging stations in Estero Bay estuary from October 2001 to September 2005. Continuous water velocity data were recorded at six of these stations for the purpose of measuring discharge. In addition, turbidity data were recorded at four stations, suspended sediment concentration were measured at three stations, and wind measurements were taken at one station. Salinity surveys, within and around Estero Bay, were conducted 15 times from July 2002 to January 2004. The average daily discharge ranged from 35,000 to -34,000 ft3/s (cubic feet per second) at Big Carlos Pass, 10,800 to -11,200 ft3/s at Matanzas Pass, 2,200 to -2,900 ft3/s at Big Hickory Pass, 680 to -700 ft3/s at Mullock Creek, 330 to -370 ft3/s at Estero River, and 190 to -180 ft3/s at Imperial River. Flood tide is expressed as negative discharge and ebb flow as positive discharge. Reduced salinity at Matanzas Pass was negatively correlated (R2 = 0.48) to freshwater discharge from the Caloosahatchee River at Franklin Locks (S-79). Matanzas Pass is hydrologically linked to Hell Peckney Bay; therefore, water-quality problems associated with the Caloosahatchee River also affect Hell Peckney Bay. Rocky Bay was significantly less saline than Coconut Point and Matanzas Pass was significantly less saline than Ostego Bay, based on data from the salinity surveys. The quality-checked and edited continuous data and the salinity maps have been compiled and are stored on the U.S. Geological Survey South Florida Information Access (SOFIA) website (

Byrne, Michael J.; Gabaldon, Jessica N.



Screening of antibacterial activity of Amaicha del Valle (Tucumán, Argentina) propolis  

Microsoft Academic Search

Propolis is extensively used in Argentine folk medicine. Alcoholic extracts of propolis from four localities of Amaicha del Valle (El Paraiso, La Banda Este, La Banda Oeste and El Molino), Province of Tucumán and from Cerrillos, Province of Santiago del Estero, Argentina were prepared. All showed antibacterial activity against Gram positive bacteria, the propolis from La Banda Este being the

M. I. Nieva Moreno; M. I. Isla; N. G. Cudmani; M. A. Vattuone; A. R. Sampietro



Assessment of photographs from wildlife monitoring cameras in Drakes Estero, Point Reyes National Seashore, California  

USGS Publications Warehouse

Between 2007 and 2010, National Park Service (NPS) staff at the Point Reyes National Seashore, California, collected over 300,000 photographic images of Drakes Estero from remotely operated wildlife monitoring cameras. The purpose of the systems was to obtain photographic data to help understand possible relationships between anthropogenic activities and Pacific harbor seal (Phoca vitulina richardsi) behavior and distribution. The value of the NPS photographs for use in assessing the frequency and impacts of seal disturbance and displacement in Drakes Estero has been debated. In September 2011, the NPS determined that the photographs did not provide meaningful information for development of a Draft Environmental Impact Statement (DEIS) for the Drakes Bay Oyster Company Special Use Permit. Limitations of the photographs included lack of study design, poor photographic quality, inadequate field of view, incomplete estuary coverage, camera obstructions, and weather limitations. The Marine Mammal Commission (MMC) reviewed the scientific data underpinning the Drakes Bay Oyster Company DEIS in November 2011 and recommended further analysis of the NPS photographs for use in characterizing rates and consequences of seal disturbance (Marine Mammal Commission, 2011). In response to that recommendation, the NPS asked the U.S. Geological Survey (USGS) to conduct an independent review of the photographs and render an opinion on the utility of the remote camera data for informing the environmental impact analyses included in the DEIS. In consultation with the NPS, we selected the 2008 photographic dataset for detailed evaluation because it covers a full harbor seal breeding season (March 1 to June 30), provides two fields of view (two cameras were deployed), and represents a time period when cameras were most consistently deployed and maintained. The NPS requested that the photographs be evaluated in absence of other data or information pertaining to seal and human activity in the estuary and that we focus on the extent to which the photographs could be used in understanding the relationship between human activity (including commercial oyster production) and harbor seal disturbance and distribution in the estuary.

Lellis, William A; Blakeslee, Carrie J.; Allen, Laurie K.; Molnia, Bruce F.; Price, Susan D.; Bristol, Sky; Stewart, Brent



Proactive investigation of hydrocarbons released into a linked groundwater-surfacewater hydrologic system: Chevron Estero Marine Terminal  

SciTech Connect

When regulatory concern is high, it is critical to address potential ecological impacts early, and hence [open quotes]close the door[close quotes] on further unnecessary studies, as illustrated by the Chevron Estero Marine Terminal case study. Cutter stock (diesel-like hydrocarbons) leaked from a facility sump, reached the water table, and migrated laterally an unknown distance. Media reports led to heightened public and regulatory concern, and the information gap led to worst-case assumptions about the extent and impact of the release to the biota of a nearby creek (Toro Creek). Chevron undertook a rapid assessment with two goals: define the extent of cutter stock in soil and groundwater, and close the door on expensive biological studies of Toro Creek. The assessment consisted of installing a large number of small-diameter soil borings and temporary well points, monitor wells, and analyzing soil, groundwater, and hydraulic gradient. The information gap was very rapidly filled with the following comprehensive picture: (1) the cutter stock had mixed with heavy crude oil, was highly adsorptive to soil and practically insoluble in water; (2) the cutter stock had not reached Toro Creek; (3) Toro Creek is always a losing stream, hydraulically connected to groundwater beneath the Chevron facility; (4) the groundwater basin is isolated by bedrock boundaries. Early attention to Toro Creek and the Pacific Ocean, and open communication with concerned agencies effectively limited the investigation to soil and water.

Tormey, D. (Entrix, Inc., Glendale, CA (United States)); Waldron, J. (Chevron USA Production Co., Bakersfield, CA (United States)); Culbertson, D. (Chevron Pipe Line Co., San Ramon, CA (United States))



Screening of antibacterial activity of Amaicha del Valle (Tucumán, Argentina) propolis.  


Propolis is extensively used in Argentine folk medicine. Alcoholic extracts of propolis from four localities of Amaicha del Valle (El Paraiso, La Banda Este, La Banda Oeste and El Molino), Province of Tucumán and from Cerrillos, Province of Santiago del Estero, Argentina were prepared. All showed antibacterial activity against Gram positive bacteria, the propolis from La Banda Este being the most active (MIC = 7.8 microg/ml) against Streptococcus piogenes, an antibiotic resistant bacterium. Thin layer chromatographic (TLC) separation profiles of propolis from Amaicha del Valle region were similar but differ from the alcoholic extract of the propolis from Cerrillos, another phytogeographical region of Argentina (provincia chaqueña). Bioautographic assays of the TLC profiles showed that several separated compounds of the Amaicha del Valle propolis have antibacterial activity. The difference in composition between Amaicha del Valle and Cerrillos propolis coincides with a different phytogeographical formation. PMID:10624867

Nieva Moreno, M I; Isla, M I; Cudmani, N G; Vattuone, M A; Sampietro, A R



Potentially Toxic Element Uptake by Bacillus jeotgali Strain U3: A Natural Attenuation Mechanism in polluted sediments from Estero de Urías Coastal Lagoon (SE Gulf of California)?  

NASA Astrophysics Data System (ADS)

In addition to an increased flux of potentially toxic elements (PTE's) into aquatic ecosystems, toxicity, bioavailability and persistency of these pollutants have led to critical localized pollution sites around the world, and the risk for the environment and the health of organism, including humans, has been increased. Clean-up technologies for the treatment of huge volumes of water, sediments and soils contaminated with these elements are needed. Use of bacteria as concentrators of PTE's can become a good tool for the remediation of man- impacted coastal ecosystems. A subtropical estuarine bacterium was isolate from surface sediments from Estero de Urías coastal lagoon, Mazatlán, Mexico, which is an aquatic ecosystem surrounded by several anthropogenic that release PTE's into the environment. This bacterial strain (U3) was ascertained (16s rRNA analysis) to belong to the Bacillus jeotgali specie. Batch experiments with different bacterial biomass and PTE (Cd, Cu, Hg, Pb and Zn) concentrations, pH and temperature were carried out in order to evaluate the biosorption capacity of Bacillus jeotgali strain U3. Except data from Zn experiments, all values were fitted to the adsorption Langmuir model. The maximum adsorption capacities (qmax) were 58 mg Cd g-1, 27 mg Cu g-1, 191 mg Hg g-1 (viable biomass), 21 mg Hg g-1 (non-viable biomass), 90 mg Pb g-1. Adsorption of Zn was 350 mg g-1, when equilibrium concentration in solution was 130 mg Zn l-1. According our data, Bacillus jeotgali strain U3 is considered as a suitable adsorbent and the presence of this microorganism in Estero de Urías coastal lagoon can produce a natural attenuation of potentially toxic elements pollution.

Green-Ruiz, C. R.; Rodríguez-Tirado, V. A.; Carrasco-Valenzuela, A. C.; Gómez-Gil, B.



Attivita del Centro di Linguistica Applicata nel campo della lingua e della cultura italiana all'estero (Activities of the Italian Center for Applied Linguistics concerning Italian Language and Culture Abroad).  

ERIC Educational Resources Information Center

Outlines the activities of a recently created section of the Italian Center for Applied Linguistics (CILA), dealing with "Teaching Italian Abroad." Describes these activities as encompassing four areas: research, teaching methodology, consultation, teachers' training and bibliographical information. Lists statistical surveys, research papers, and…

Boriosi Katerinov, Maria Clotilde



Análisis descriptivo del tamaño relativo del gasto del gobierno chileno  

Microsoft Academic Search

En este trabajo se examina el tamaño relativo del Gobierno chileno a través de una comparación internacional con valores equivalentes de otros países. Adicionalmente hay un análisis similar para dos componentes importantes del gasto público: educación y salud. El gasto del Gobierno de Chile, valor en torno del 20% (PIB), está junto al tercio inferior de países que poseen un

Eduardo Engel; Patricio Meller; Claudio Bravo



Atlas del Genoma del Cáncer

Es posible que haya más de 200 tipos diferentes de cáncer y muchos subtipos más, cada uno de estos causado por errores en el ADN que desencadenan el crecimiento descontrolado de las células. La identificación de los cambios en el conjunto completo de ADN de cada tipo de cáncer, su genoma, y el entendimiento de cómo interactúan dichos cambios para impulsar el proceso de la enfermedad sentarán las bases de una era individualizada de tratamiento del cáncer.


Instantánea del cáncer infantil

Información sobre la incidencia y mortalidad del cáncer en los niños, tendencias en el financiamiento del NCI para la investigación del cáncer infantil; así como ejemplos de actividades y adelantos en la investigación relevantes para esta población.


Políticas del sitio web

En el sitio web del NCI se proporcionan enlaces a otros sitios web con fines informativos y para conveniencia del público. Si el usuario selecciona un sitio web externo, saldrá del sitio web del NCI y estará sujeto a las políticas de privacidad y seguridad de dicho sitio.


Instantánea del cáncer colorrectal

Información sobre las tendencias de incidencia, mortalidad y financiamiento del NCI sobre el cáncer colorrectal; así como ejemplos de actividades del NCI y adelantos en la investigación de este tipo de cáncer.


Boletín del Instituto Nacional del Cáncer - 16 de enero 2013

El Boletín del Instituto Nacional del Cáncer ha suspendido su publicación a partir del 16 de enero de 2013. El archivo del Boletín, que cuenta con todas las ediciones publicadas desde 2009 a 2013, permanecerá a disposición de los lectores en el sitio web del NCI.


La teoria del pendolo  

Microsoft Academic Search

Il silenzio era tale che, ascoltando attentamente, si sarebbe potuto udire la voce dell'anima. Era proprio questo il motivo per cui Galileo si alzava ogni mattina di buon ora per dire le sue orazioni innanzi al maestoso altare del duomo. Guardava a lungo le volte intorno a lui cercando con lo sguardo la perfezione del creato e poi, con l'ambiguità

Di Claudio Chillemi


Evaluación del desempeño integral del sector transporte  

Microsoft Academic Search

Las organizaciones hoy por hoy buscan aplicar un sistema de indicadores que evalúe la gestión y el desempeño del sector transporte en materia económica, social, ambiental e integral, con el fin de garantizar a las partes interesadas una información confiable sobre los resultados de desempeño frente al desarrollo sostenible, que facilite el ingreso a mercados nacionales e internacionales a partir

Clara Inés Pardo Martínez



Boletín del Instituto Nacional del Cáncer - 07-20-2010

El doctor Harold Varmus, acompañado de su esposa Constance Casey (centro), presta juramento como director del NCI ante la Secretaria del Departamento de Salud y Servicios Humanos, Kathleen Sebelius, el lunes 12 de julio. (Foto cortesía de Chris Smith) El 12 de julio, el doctor Harold Varmus prestó juramento ante la Secretaria del Departamento de Salud y Servicios Humanos de los Estados Unidos, Kathleen Sebelios, como el decimocuarto director del Instituto Nacional del Cáncer.


Hojas informativas del NCI

La colección de hojas informativas del NCI trata de una variedad de temas relacionados con el cáncer. Las hojas informativas se revisan y ponen al día de acuerdo a las investigaciones más recientes sobre el cáncer.


Il problema del litio.  

NASA Astrophysics Data System (ADS)

Contents: 1. Introduzione. 2. La nucleosintesi del Big Bang. 3. Il litio nelle stelle di popolazione II. 4. I modelli stellari standard. 5. Il litio negli ammassi aperti. 6. Meccanismi di distruzione "non standard". 7. I modelli non-standard applicati alla popolazione II. 8. L'evoluzione Galattica del litio. 9. Quali stelle producono litio? 10. Il litio come elemento chiave per dare un nome agli oggetti stellari più minuscoli. 11. Conclusioni.

D'Antona, F.



Amenazas comerciales del Acuerdo Can-Mercosur para los sectores productivos del Valle del Cauca  

Microsoft Academic Search

El Acuerdo de Complementación Económica, suscrito entre la Comunidad Andina (CAN) y el Mercado Común del Sur (MERCOSUR), marca un avance hacia una integración económica y política más profunda en América Latina. Por tal razón, el objetivo del presente artículo es identificar los sectores del Valle del Cauca que revelan desventajas competitivas relativas, por lo que se pueden ver potencialmente

Lya Paola Sierra Suárez; José Tomás Peláez Soto




Microsoft Academic Search

Esta investigación tuvo como objetivo determinar las características del proceso instruccional en la tercera etapa del nivel de Educación Básica que contribuyen al desarrollo del pensamiento crítico del estudiante para satisfacer el imperativo legal vigente desde julio de 1980, particularmente para el área curricular Estudios Sociales. Durante cuatro años escolares en dos instituciones educativas que ofrecen el precitado nivel se

Haydée Páez


Espectroscopia del Cometa Halley  

NASA Astrophysics Data System (ADS)

Se reportan observaciones espectroscópicas del cometa Halley. Los espectros fueron tomados usando el espectrógrafo del telescopio reflector de 1 metro del Observatorio Nacional de Venezuela. Se utilizó óptica azul, con una red de difracción de 600 lineas/min, obteniéndose una dispersión de 74.2 A/mm y una resolución de 2.5 A, en el rango espectral de 3500 a 6500 A. Seis placas fueron tomadas con emulsión IIa-O y dos con IIa-D. Los tiempos de exposición fueron entre 10 y 150 minutos. El cometa se encontraba entre 0.70 y 1.04 UA del Sol, y entre 1.28 y 0.73 UA de la Tierra. Las emisiones más prominentes en el espectro, son las del CN, C2, y C3. Otras emisiones detectadas corresponden a CH, NH2 y Na. Los espectros muestran un fuerte continuo, indicando un contenido significativo de polvo. Se detectó mayor intensidad del contínuo, en la dirección anti solar, lo cual es evidencia de la cola de polvo.

Naranjo, O.; Fuenmayor, F.; Ferrin, L.; Bulka, P.; Mendoza, C.



Boletín del Instituto Nacional del Cáncer

No se puede negar que vivimos en una comunidad global, en la que los eventos de una ciudad o país pueden tener graves consecuencias para los residentes de otra ciudad o país a miles de kilómetros de distancia. Ya sea la pandemia del virus H1N1, los recientes disturbios en Irán o la recesión económica mundial, es evidente que esta interconectividad trae consigo retos importantes. Pero también puede crear oportunidades sin precedentes, en particular aquellas que podrían mejorar sustancialmente la salud pública.


Pruebas de Papanicolaou y del virus del papiloma humano (VPH)

Hoja informativa que describe los exámenes selectivos de detección del cáncer de cérvix, los cuales incluyen la prueba de Papanicolaou y la prueba de los virus del papiloma humano. La hoja informativa incluye también información acerca de las pautas de exámenes de detección del cáncer de cérvix.


Instantánea del cáncer de esófago

Información sobre las tendencias de incidencia, mortalidad y financiamiento del NCI sobre el cáncer de esófago; así como ejemplos de actividades del NCI y adelantos en la investigación de este tipo de cáncer.


Instantánea del cáncer de próstata

Información sobre las tendencias de incidencia, mortalidad y financiamiento del NCI sobre el cáncer de próstata; así como ejemplos de actividades del NCI y adelantos en la investigación de este tipo de cáncer.


Instantánea del cáncer de estómago

Información sobre las tendencias de incidencia, mortalidad y financiamiento del NCI sobre el cáncer de estómago; así como ejemplos de actividades del NCI y adelantos en la investigación de este tipo de cáncer.


Instantánea del sarcoma de Kaposi

Información sobre las tendencias de incidencia, mortalidad y financiamiento del NCI sobre el sarcoma de Kaposi; así como ejemplos de actividades del NCI y adelantos en la investigación de este tipo de cáncer.


Instantánea del cáncer de tiroides

Información sobre las tendencias de incidencia, mortalidad y financiamiento del NCI sobre el cáncer de tiroides; así como ejemplos de actividades del NCI y adelantos en la investigación de este tipo de cáncer.


Instantánea del cáncer de ovario

Información sobre las tendencias de incidencia, mortalidad y financiamiento del NCI sobre el cáncer de ovario; así como ejemplos de actividades del NCI y adelantos en la investigación de este tipo de cáncer.


Instantánea del cáncer de endometrio

Información sobre las tendencias de incidencia, mortalidad y financiamiento del NCI sobre el cáncer de endometrio; así como ejemplos de actividades del NCI y adelantos en la investigación de este tipo de cáncer.


Instantánea del cáncer de vejiga

Información sobre las tendencias de incidencia, mortalidad y financiamiento del NCI sobre el cáncer de vejiga; así como ejemplos de actividades del NCI y adelantos en la investigación de este tipo de cáncer.


Instantánea del cáncer de riñón

Información sobre las tendencias de incidencia, mortalidad y financiamiento del NCI sobre el cáncer de riñón; así como ejemplos de actividades del NCI y adelantos en la investigación de este tipo de cáncer.


Instantánea del cáncer de páncreas

Información sobre las tendencias de incidencia, mortalidad y financiamiento del NCI sobre el cáncer de páncreas; así como ejemplos de actividades del NCI y adelantos en la investigación de este tipo de cáncer.


Instantánea del cáncer de pulmón

Información sobre las tendencias de incidencia, mortalidad y financiamiento del NCI sobre el cáncer de pulmón; así como ejemplos de actividades del NCI y adelantos en la investigación de este tipo de cáncer.


Documenting Endangered Languages (DEL)  

NSF Publications Database

Full Proposal Preparation Instructions: This solicitation contains information that supplements the standard Grant Proposal Guide (GPG) proposal preparation guidelines. All DEL proposals for project grants and fellowships will receive specialist (ad hoc) and panel review within the NSF review process. More comprehensive information on NSF Award Conditions is contained in the NSF Grant Policy Manual (GPM) Chapter II, available electronically on the NSF Website at


Nevado del Huila, Columbia  

NASA Technical Reports Server (NTRS)

Nevado del Huila Volcano in Colombia is actually a volcanic chain running north to south, capped by a glacier. With peaks ranging in height from 2,600 to 5,780 meters (8,530 to 18,960 feet), Nevado del Huila is a stratovolcano composed of alternating layers of hardened lava, solidified ash, and volcanic rocks. Its first recorded eruption occurred in the mid-sixteenth century. The long-dormant volcano erupted again in mid-April 2007. A few months before the eruption, the Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER) on NASA's Terra satellite captured this image of Nevado del Huila, on February 23, 2007. In this image, the bright white area just east of the central summit is ice. Immediately west of the summit are bare rocks, appearing as blue-gray. West of those rocks, white reappears, but this patch of white results from clouds hovering in the nearby valley. In the east, the colors turn to brown (indicating bare rock) and bright green (indicating vegetation). ASTER photographed Nevado del Huila near the end of a long phase of quietude. On April 17, 2007, local authorities recorded seismic activity associated with rock fracturing on the volcano's central summit, according to the ReliefWeb Website. Activity intensified the following day with an eruption and mudflows, forcing thousands of nearby residents to evacuate. As the Associated Press reported, the eruption caused avalanches and floods that wiped away both houses and bridges. It marked the volcano's first recorded eruption since the Spanish colonized the area five centuries earlier. NASA image created by Jesse Allen, using data provided courtesy of the NASA/GSFC/MITI/ERSDAC/JAROS, and U.S./Japan ASTER Science Team.



Boletín del Instituto Nacional del Cáncer - 02-02-2010

En un estudio clínico en fase inicial que probó una vacuna terapéutica en pacientes con leucemia mieloide crónica (LMC) que tomaban el fármaco imatinib (Gleevec), no se pudieron detectar células cancerosas en 7 de los 19 participantes por un tiempo promedio de 22 meses. Los resultados del estudio fueron publicados en el número del 1º de enero de la revista Clinical Cancer Research.


Vacunas contra los virus del papiloma humano

Hoja informativa acerca de las vacunas contra los virus del papiloma humano (VPH) para prevenir infecciones con ciertos tipos de VPH, los cuales son la causa principal del cáncer de cuello del útero o cérvix.


Siga adelante: la vida después del tratamiento del cáncer

Consejos para supervivientes de cáncer con información sobre temas relacionados con la vida después del tratamiento, entre ellos, la atención médica de seguimiento, los cambios físicos y emocionales y los cambios en el estilo de vida.


Siga adelante: la vida después del tratamiento del cáncer

E-book con consejos para supervivientes de cáncer e información sobre temas relacionados con la vida después del tratamiento, entre ellos, la atención médica de seguimiento, los cambios físicos y emocionales y los cambios en el estilo de vida.


Boletín del Instituto Nacional del Cáncer - 05-25-2010

Aproximadamente 41.000 participantes en un estudio en el Reino Unido se sometieron una sola vez a una examen de detección en la parte inferior del colon mediante el uso de un sigmoidoscopio, un instrumento delgado en forma de tubo que se inserta a través del recto para buscar lesiones precancerosas o cancerosas. Este dispositivo también tiene una herramienta para extraer pólipos potencialmente precancerosos.


Se da a conocer el plan del Instituto Nacional del Cáncer para acelerar la investigación del cáncer

En la 100va Reunión Anual de la Asociación Estadounidense de Investigación del Cáncer realizada en Denver, el director del Instituto Nacional del Cáncer, doctor John E. Niederhuber, dio a conocer detalles importantes, tales como financiamiento de más subvenciones, creación de una plataforma para atención personalizada del cáncer y un programa acelerado de genética del cáncer que hará avanzar la investigación oncológica en este nuevo ambiente económico.



Microsoft Academic Search

Resumen: En el modelado fisiológico, el propósito es comprender las funciones del cuerpo humano. Con este propósito, se abordan problemas del embarazo y el parto para minimizar las cesáreas innecesarias en mujeres propensas a cursar con Sufrimiento Fetal Agudo (SFA). En el presente estudio se realizó: el Modelado Matemático del Sistema Cardiovascular Fetal (SCVF), la Simulación y Validación del SCVF.

Rubén Moreno


Antioxidantes y prevención del cáncer

Hoja informativa acerca de los antioxidantes, sustancias que pueden proteger las células del daño causado por moléculas inestables conocidas como radicales libres. El daño de los radicales libres puede resultar en cáncer.


Case Study: del Amo Bioventing  

EPA Science Inventory

The attached presentation discusses the fundamentals of bioventing in the vadose zone. The basics of bioventing are presented. The experience to date with the del Amo Superfund Site is presented as a case study....


Alberto del Pozo  

NSDL National Science Digital Library

The Cuban Heritage Collection of the University of Miami Libraries was a recipient of 17 original illustrations by Alberto del Pozo in 1998 from the Campilli family. "The Oricha Collection" is their gift, and it contains illustrations in pen, crayon, and ink and the collection "pays homage to the primary gods and goddesses that comprise the Afro-Cuban religion of Santer'a." The "Introduction" near the top of the page, is a good place for visitors to start learning about Pozo, who was a Parson's School of Design-trained, Cuban artist who died at the age of 47. The "Biographical Sketch" is worth looking at as well. Examples of his colorful, heavily patterned and symbolism-intensive drawings of Santeria gods and goddesses can be found in the link "Gallery". The description of each drawing is given in English and Spanish. Finally, visitors interested in more information on the Santeria, can look at the "Further Readings" link for authoritative books on the subject.


Boletín del Instituto Nacional del Cáncer - 28 de febrero de 2012

Los artículos originales en inglés están disponibles en las páginas del NCI Cancer Bulletin. El Boletín es una publicación del Instituto Nacional del Cáncer (NCI), una entidad gubernamental de los Estados Unidos creada en 1937.


Boletín del Instituto Nacional del Cáncer - 01-05-2010

Al caminar por los pasillos del nuevo centro oncológico integral en la sede de Ciencias Médicas de la Universidad de Puerto Rico (UPR) en San Juan, uno debe mantener los ojos abiertos. La mujer que pasa caminando vigorosamente podría ser la doctora Marcia Roxana Cruz-Correa, y no debe uno perderse la oportunidad de conocerla.


Boletín del Instituto Nacional del Cáncer - 04-27-2010

Cada vez es más evidente que los esfuerzos mundiales de salud de mayor éxito dependen no solo del aporte de las mentes más brillantes, sino de la colaboración entre ellas para marcar la diferencia en el escenario global. Este enfoque es el motor impulsor detrás de una asociación excepcional con el NCI, financiada en parte por Susan G.


La Investigación del Cáncer en América Latina

Este programa busca fomentar los esfuerzos locales y mundiales de prevención, diagnóstico y tratamiento del cáncer facilitando la creación de una infraestructura integral para la investigación del cáncer en América Latina.


Instantánea del cáncer de cuello uterino

Información sobre las tendencias de incidencia, mortalidad y financiamiento del NCI sobre el cáncer de cuello uterino; así como ejemplos de actividades del NCI y adelantos en la investigación de este tipo de cáncer.


Instantánea del cáncer de seno (mama)

Información sobre las tendencias de incidencia, mortalidad y financiamiento del NCI sobre el cáncer de seno (mama); así como ejemplos de actividades del NCI y adelantos en la investigación de este tipo de cáncer.


Geología y registros magnéticos entre arroyo La Tapera y Santa Clara del Mar, Mar del Plata  

Microsoft Academic Search

Geology and magnetic records between Arroyo La Tapera and Santa Clara del Mar, Mar del Plata. Paleomagnetic studies were carried out in Pleistocene-Holocene sedimentary sequences exposed between Arroyo La Tapera and Santa Clara del Mar in Mar del Plata. The sediments exposed in the lower part of the La Tapera and Camet sections, which apparently belong to the Ensenada Formation,

Juan Carlos BIDEGAIN; Margarita L. OSTERRIETH; Adrianus J. VAN VELZEN; Yamile RICO


Variabilità interannuale del fi toplancton del Lago di Tovel (Trentino, Italia)  

Microsoft Academic Search

RIASSUNTO - Variabilità interannuale del fi toplancton del Lago di Tovel (Trentino, Italia) - Lo studio del fi toplancton del Lago di Tovel nel periodo 2002-2004 ha avuto come principali obiettivi l'analisi della variabilità interannuale delle dinamiche stagionali nel Bacino Principale e nella Baia Rossa, il confronto tra le associazioni fi toplanctoniche attuali e passate (prima e dopo la scomparsa



Características del desplazamiento forzado en Colombia  

Microsoft Academic Search

RESUMEN El presente estudio es una contribución a la explicación y comprensión de la problemática del desplazamiento forzado interno en Colombia, fenómeno considerado como violación masiva y múltiple de los derechos humanos, circunstancia de lesa humanidad además de ser infracción grave del Derecho Internacional Humanitario. Se identificaron los antecedentes históricos, la dinámica regional del fenómeno, la existencia de factores estructurales

Henry Fernández Pinto; JIMMY SÁNCHEZ REYEZ



Del Mar College GIS Program  

NSDL National Science Digital Library

Del Mar College offers a comprehensive geospatial program with certificates and Associates degrees in GIS. This site includes description of the program and courses, along with further contact information. By clicking on the link for "Geographic Information Systems" you may download a PDF with information about the program.



Los cuatro entornos del procomún  

Microsoft Academic Search

Bastan unos minutos para entender la inmensa complejidad que tiene la noción de procomún. Disponemos de muchas definiciones aceptables, aunque las más frecuentes bordean de una u otra manera el problema de la propiedad y la teoría del valor. Cuando decimos que pertenece al procomún todo cuanto es de todos y de nadie a mismo tiempo estamos pensando en un

Antonio Lafuente


Trasformazioni e patologie del paesaggio  

Microsoft Academic Search

\\u000a Anche il paesaggio, come vedremo, si evolve. Ma parlare oggi di evoluzione è assai problematico e quindi non si può fare a\\u000a meno di un inquadramento più generale del fenomeno. Quando oggi si parla di evoluzione si presenta sovente un quadro che,\\u000a purtroppo, non ha sempre i caratteri della scienza e un dibattito che, di conseguenza, trascina polemiche anche fra

Vittorio Ingegnoli


Ayuda para usar el sitio web en español del Instituto Nacional del Cáncer

Página de guía que le permite al lector entender la forma en que está organizado el sitio web del Instituto Nacional del Cáncer (NCI), las categorías de información disponibles y las políticas que rigen este sitio web.


Aplicación del cálculo de las diferencias al problema del efecto de embalse  

Microsoft Academic Search

Resumen Presentamos una solución numérica del problema del efecto de embalse con ayuda de una ecuación lineal inhomogénea en diferencias finitas de primer orden, suponiendo una ley lineal del desagüe. Este método numérico es de maneje cómodo para un cálculo aproximado.

Hans Ertel



Control del dolor: Apoyo para las personas con cáncer

Libro sobre el control del dolor en pacientes con cáncer. Cubre los métodos y medicinas, así como los efectos físicos y emocionales del dolor. Es una adaptación cultural para el público de habla hispana del libro en inglés Pain Control.


Fractional Indices of Log del Pezzo Surfaces  

NASA Astrophysics Data System (ADS)

The fractional index of a (possibly singular) Q-Gorenstein del Pezzo surface X is the greatest rational number r such that -K_X\\equiv rH, where H is a primitive Cartier divisor. This paper describes the set of values taken by fractional indices of del Pezzo surfaces with log terminal singularities. Bibliography: 7 titles.

Alekseev, V. A.



Fisiología del embarazo: Interacción materno-infantil  

Microsoft Academic Search

ResumenEn los últimos años los datos han demostrado de qué manera el bienestar vitalicio depende considerablemente del crecimiento y el desarrollo intrauterinos durante la vida dentro del útero. El crecimiento fetal puede alcanzar únicamente su potencial íntegro mediante una interacción adecuada y armonizada entre la madre, la placenta y el feto. Este delicado equilibrio puede ser alterado por varios factores

Irene Cetin; Manuela Cardellicchio



La gestione perioperatoria del paziente diabetico  

Microsoft Academic Search

\\u000a Il continuo aumento dei pazienti diabetici che giungono all’osservazione degli anestesisti rende sempre più importante la\\u000a conoscenza delle patologie comunemente associate al diabete e delle strategie da attuare per mantenere un equilibrio glicemico\\u000a ottimale nel periodo perioperatorio.\\u000a \\u000a \\u000a Per questa ragione, dopo aver sinteticamente descritto il metabolismo del glucosio, verrà trattato in questo capitolo il problema\\u000a del corretto trattamento insulinico del

Biagio Allaria


Centro para la Salud Mundial del NCI

El Centro para la Salud Mundial del NCI coordina actividades de investigación y trabaja con socios nacionales e internacionales para entender y enfrentar la carga que representa el cáncer a nivel mundial.


Exploración del Nuevo Laboratorio Científico de Marte  

NASA Video Gallery

Únase a Fernando Abilleira, un analista de trayectoria de la NASA para la Oficina de Exploración de Marte, y conozca las nuevas tecnologías que el nuevo robot Curiosity del Laboratorio Científico d...


Dust formation in Nova Del 2013  

NASA Astrophysics Data System (ADS)

We present the result of the IR photometry of Nova Del 2013 obtained at the Crimean Station (Nauchny, Ukraine) of the Sternberg Astronomical Institute. JHKLM photometry was carried out with 125-cm telescope using a InSb-photometer on:

Shenavrin, V. I.; Taranova, O. G.; Tatarnikov, A. M.




Microsoft Academic Search

Se realiza un estudio comparado del grado de desarrollo del gobierno electrónico en distintas regiones y países del mundo, dedicándole una atención particular al caso Cuba. Para ello se utiliza el Índice de desarrollo de gobierno electrónico (IDGE) establecido por las Naciones Unidas. A partir de los componentes del IDGE que son, el índice de servicios en línea (ISL), el

Alejandro de Armas Suárez; Roberto de Armas Urquiza



Manual del McVCO 1999  

USGS Publications Warehouse

El McVCO es un generador de frecuencias basado en un microcontrolador que reemplaza al oscilador controlado por voltaje (VCO) utilizado en telemetría analógica de datos sísmicas. Acepta señales de baja potencia desde un sismómetro y produce una señal subportadora modulada en frecuencia adecuada para enlaces telefónicos o vía radio a un lugar remoto de recolección de datos. La frecuencia de la subportadora y la ganancia pueden ser seleccionadas mediante un interruptor. Tiene la opción de poder operar con dos canales para la observación con ganancia alta y baja. El McVCO fue diseñado con el propósito de mejorar la telemetría analógica de las señales dentro de la Pacific Northwest Seismograph Network (PNSN) (Red Sismográfica del Noroeste del Pacífico). Su desarrollo recibió el respaldo del Programa de Geofísica de la Universidad de Washington y del "Volcano Hazards and Earthquake Hazards programs of the United States Geological Survey (USGS) (Programa de Investigaciones de Riesgos Volcánicos y Programa de Investigaciones de Riesgos Sísmicos de los EEUU). Cientos de instrumentos se han construido e instalado. Además de utilizarlo el PNSN, el McVCO es usado por el Observatorio Vulcanológico de Alaska para monitorear los volcanes aleutianos y por el USGS Volcano Disaster Assistance Program (Programa de Ayuda en las Catástrofes Volcánicas del USGS) para responder a crisis volcánicas en otros países. Este manual cubre el funcionamiento del McVCO, es una referencia técnica para aquellos que necesitan saber con más detalle cómo funciona el McVCO, y cubre una serie de temas que requieren un trato explícito o que derivan del despliegue del instrumento.

McChesney, P.J.



La capacidad redistributiva y estabilizadora del presupuesto del gobierno central español  

Microsoft Academic Search

El objetivo de este trabajo es estimar los efectos redistributivo y estabilizador\\/asegurador del presupuesto de la Administración Pública Central española en el período 1991-1996 a nivel regional. Este análisis se lleva a cabo para el conjunto del presupuesto a través de los saldos fiscales regionales y, separadamente, para el conjunto de ingresos y gastos y sus principales categorías. La metodología




Rapporto del Sottocomitato Ricerca del Workshop Internazionale dell'Occhio Secco (2007)  

Microsoft Academic Search

I membri del Sottocomitato Ricerca del DEWS hanno esaminato i dati in letteratura relativi meccanismi ba- se della malattia dell'occhio secco. Sono state valutate le evidenze scientifiche riguardanti il film lacrimale, la ghian- dola lacrimale primaria e le ghiandole lacrimali accessorie, gli epiteli della superficie oculare (incluse cornea e con- giuntiva), le ghiandole di Meibomio, il sistema dei dotti lacri-

Membri del Sottocomitato Ricerca; Ilene K. Gipson; Pablo Argüeso; Roger Beuerman; Stefano Bonini; Igor Butovich; Reza Dana; Darlene Dartt; Dan Gamache; Bryan Ham; Marcia Jumblatt; Donald Korb; Friederich Kruse; Yoko Ogawa; Friedrich Paulsen; Michael Stern; Deborah F. Sweeney; John Tiffany; John Ubels; Mark Willcox


Valoración económica del ruido: una aplicación a través del método de transferencia de beneficios  

Microsoft Academic Search

Este artículo tiene como objetivo realizar una aproximación a la valoración económica de los beneficios de la reducción del ruido generado por infraestructuras de telecomunicaciones en cuatro zonas urbanas del área metropolitana de la ciudad de Medellín (Colombia). Así, mediante el método de transferencia de beneficios, en un horizonte a perpetuidad, se obtuvo un valor económico de $79,40 millones para

Francisco Javier Correa Restrepo; Juan David Osorio Múnera; Bernardo Andrés Patiño Valencia



Efectos del color en la aceptabilidad, artificialidad, dulzor e intensidad del sabor de bebidas lácteas  

Microsoft Academic Search

El objetivo del presente estudio es analizar el efecto de la concentración de colorantes en bebidas lác- teas (batidos de vainilla) y de los parámetros de color, pureza o c ro m a, cl a ridad y tono, sobre las ex- p e c t at ivas del grado de acep t abilidad global de dichas bebidas así como sobre

T. Coello García; C. Díaz Berciano; N. Gómez Pestaña



Intertextual Sexual Politics: Illness and Desire in Enrique Gomez Carrillo's "Del amor", "del dolor y del vicio" and Aurora Caceres's "La rosa muerta"  

ERIC Educational Resources Information Center

This study explores the intertextuality between Aurora Caceres's "La rosa muerta" (1914) and the novel "Del amor, del dolor y del vicio" (1898) by her ex-husband, Enrique Gomez Carrillo. Caceres strategically mentions Gomez Carrillo's novel in "La rosa muerta" to invite a reading of her work in dialogue with his. Both narratives follow the sexual…

LaGreca, Nancy



Extensión del Formalismo de Orbitales de Defecto Cuántico al tratamiento del efecto Stark (SQDO).  

NASA Astrophysics Data System (ADS)

El estudio experimental de las interacciones de átomos Rydberg altamente excitados con campos eléctricos ha experimentado un creciente interés durante las dos últimas décadas debido, en gran medida, al desarrollo de nuevas técnicas para crear y estudiar átomos Rydberg en el laboratorio. Acompañando a estas nuevas técnicas experimentales, es necesario el desarrollo de modelos teóricos que nos permitan contrastar sus medidas y conocer mejor los fundamentos de los mismos. Desde el punto de vista teórico el conocimiento del desdoblamiento de los niveles energéticos de un átomo en función de la magnitud del campo eléctrico aplicado (lo que se conoce como mapa Stark) es el mejor punto de partida para la descripción del sistema y un prerrequisito fundamental para el cálculo de distintas propiedades atómicas en presencia del campo eléctrico tales como intensidades de transición, umbrales de ionización de campo eléctrico, tiempos de vida, posición y anchura de cruces evitados, etc. En este trabajo presentamos la adaptación del método de orbitales de defecto cuántico [1,2,3] al tratamiento del efecto Stark (SQDO) [4] y su aplicación al cálculo de los desdoblamientos energéticos y fuerzas de oscilador de estados Rydberg en los átomos de Li, Na y K. El propósito de este estudio es, por un lado, desarrollar métodos fiables para la determinación de propiedades atómicas en presencia de campos eléctricos y, por otro, mostrar la fiabilidad de las funciones de onda QDO en la descripción del efecto Stark en sistemas atómicos.

Menéndez, J. M.; Martín, I.; Velasco, A. M.


El Servicio de Información sobre el Cáncer del Instituto Nacional del Cáncer

El Servicio de Información del Cáncer (CIS) del Instituto Nacional del Cáncer facilita la información más actualizada y precisa sobre el cáncer a pacientes, a sus familias, al público en general y a profesionales médicos. El CIS brinda respuestas personalizadas a preguntas específicas sobre el cáncer y asistencia a los fumadores que quieren abandonar el hábito. Comuníquese con el CIS al 1-800-422-6237 (1-800-4-CANCER) o al 1-877-448-7848 (1-877-44U-QUIT).


La reconstrucción del seno después de una mastectomía

Hoja informativa que describe la reconstrucción del seno (mama) después de una mastectomía. Contiene información sobre las opciones quirúrgicas, los cuidados de seguimiento y los exámenes de detección del cáncer de seno después de la reconstrucción.


Transformación de los programas de estudios clínicos del NCI

Información sobre los programas e iniciativas del NCI que patrocinan, realizan, crean o apoyan estudios clínicos, entre los que se incluyen la Red Nacional de Estudios Clínicos (NCTN) y el Programa de Investigación Oncológica Comunitaria (NCORP) del NCI.


Exportaciones del Sector Maderas y Papeles No Tradicional  

Microsoft Academic Search

fueron México (23.0% % de participación), Estados Unidos (15.4%), China (15.1%), Venezuela (8.2%) y Ecuador (8.1%). En conjunto estos cinco países concentraron el 66.8.0% del total de exportaciones del sector. Las ventas hacia los mercados de México, China, Ecuador y Venezuela, fueron superiores a las registradas en el mismo periodo del 2007, creciendo durante los primeros seis meses del año

Millones FOB


33 CFR 80.1118 - Marina Del Rey, CA.  

Code of Federal Regulations, 2013 CFR

...1 2013-07-01 2013-07-01 false Marina Del Rey, CA. 80.1118 Section 80.1118 Navigation and Navigable Waters...DEMARCATION LINES Pacific Coast § 80.1118 Marina Del Rey, CA. (a) A line drawn from Marina Del Rey Breakwater South...



Boletín del Instituto Nacional del Cáncer - 8 de noviembre de 2011

Le invitamos a que comparta esta publicación con sus amigos, familiares y colegas y nos ayude a continuar nuestra misión de difundir las investigaciones más recientes sobre la prevención, el tratamiento y la información del cáncer.


Impacto del conflicto colombiano en los periodistas  

Microsoft Academic Search

Introducción: Este artículo esboza las dificultades que presentan los periodistas colombianos en su trabajo y caracteriza el impacto del conflicto armado colombiano en su relación con este ejercicio profesional. Método: Los autores realizaron 70 entrevistas a algunos periodistas colombianos que cubren el conflicto. Para el análisis de las entrevistas se intentó entender la lógica de su conducta y cómo representan

Ismael Roldán; Diana Sofía Giraldo; Miguel Ángel Flórez



Exámenes selectivos de detección del cáncer colorrectal

Un ejemplo excelente del poder de la investigación de prevención es el progreso sustancial que hemos logrado en la reducción de la incidencia y muerte por cáncer colorrectal, con nuevos conocimientos que iluminan el camino a incluso mayores reducciones en un futuro cercano.


Vigilando la Calidad del Agua de los Grandes Rios de la Nacion: El Programa NASQAN del Rio Grande (Rio Bravo del Norte)  

USGS Publications Warehouse

La Oficina del Estudio Geologico de los Estados Unidos (U.S. Geological Survey, 0 USGS) ha monitoreado la calidad del agua de la cuenca del Rio Grande (Rio Bravo del Norte) desde 1995 como parte de la rediseiiada Red Nacional para Contabilizar la Calidad del Agua de los Rios (National Stream Quality Accounting Network, o NASOAN) (Hooper and others, 1997). EI programa NASOAN fue diseiiado para caracterizar las concentraciones y el transporte de sedimento y constituyentes quimicos seleccionados, encontrados en los grandes rios de los Estados Unidos - incluyendo el Misisipi, el Colorado y el Columbia, ademas del Rio Grande. En estas cuatro cuencas, el USGS opera actualmente (1998) una red de 40 puntos de muestreo pertenecientes a NASOAN, con un enfasis en cuantificar el flujo en masa (la cantidad de material que pasa por la estacion, expresado en toneladas por dial para cada constituyente. Aplicacando un enfoque consistente, basado en la cuantificacion de flujos en la cuenca del Rio Grande, el programa NASOAN esta generando la informacion necesaria para identificar fuentes regionales de diversos contaminantes, incluyendo sustancias qui micas agricolas y trazas elementos en la cuenca. EI efecto de las grandes reservas en el Rio Grande se puede observar segun los flujos de constituyentes discurren a 10 largo del rio. EI analisis de los flujos de constituyentes a escala de la cuenca proveera los medios para evaluar la influencia de la actividad humana sobre las condiciones de calidad del agua del Rio Grande.

Lurry, Dee L.; Reutter, David C.; Wells, Frank C.; translated by Rivera, M.C.; Munoz, A.



Boletín del Instituto Nacional del Cáncer - 31 de enero de 2012

Dr. Nils Daulaire Salud mundial a través de la colaboración y el liderazgo Para conmemorar el Día Mundial del Cáncer que tuvo lugar el 4 febrero, el doctor Nils Daulaire, director de la Oficina de Asuntos Internacionales del Departamento de Salud y Servicios Humanos de los Estados Unidos habla sobre las razones por las cuales los Estados Unidos deben participar en iniciativas para mejorar la salud mundial.


Comportamiento del Helio en estrellas químicamente peculiares  

NASA Astrophysics Data System (ADS)

Las estrellas químicamente peculiares (CP) se caracterizan por tener deficiencias y sobreabundancias de algunos elementos químicos de hasta 106 veces la abundancia solar. Además presentan variaciones en las líneas espectrales. Se piensa que ello se debe a que los campos magnéticos presentes en este tipo de estrellas son principalmente dipolares, con un eje de simetría diferente del eje de rotación. La distribución de los elementos sobreabundantes y deficientes no es homogénea sobre la superficie estelar y las variaciones observadas serían una consecuencia directa de la rotación estelar. Entre los elementos con abundancia anómala se encuentra el Helio, cuyas líneas tienen intensidades que no son consistentes con una abundancia normal, que no puede ser determinada del modo usual, o sea, considerando una atmósfera con composición solar. Con el fin de determinar la abundancia de este elemento, se inició un estudio de estrellas anómalas de Helio, Hew y He strong. Además se determinarán las abundancias de otros elementos anómalos como ser el Si, Cr, Mg, Mn y Fe. Las mismas se determinan del modo tradicional, o sea: a) medida de los anchos equivalentes de las líneas de los distintos elementos analizados; b) adopción de la temperatura efectiva, gravedad y abundancia del Helio; c) cálculo del modelo de atmósfera d) comparación con las observaciones y reinicio de un proceso iterativo hasta lograr un acuerdo entre todos los parámetros analizados. Las observaciones se llevaron a cabo en el Complejo Astronómico El Leoncito. Se observaron setenta y ocho estrellas anómalas de Helio. En este momento se está procediendo a calcular las abundancias correspondientes a los distintos elementos químicos. Para ello se hace uso de los modelos de Kurucz, ATLAS9. Los cálculos NLTE de las líneas de Helio se llevan a cabo con el programa MULTI y se compararán con los realizados con el programa WIDTH9 de Kurucz (LTE), con el objeto de resaltar la importancia de los efectos NLTE.

Malaroda, S. M.; López García, Z.; Leone, F.; Catalano, F.


Isolation of Paecilomyces lilacinus (Thom) Samson (Ascomycota: Hypocreales) from the Chagas disease vector, Triatoma infestans Klug (Hemiptera: Reduviidae) in an endemic area in Argentina  

Microsoft Academic Search

A survey for entomopathogenic fungi of the Chagas disease vector Triatoma infestans was conducted in two provinces of Argentina from March–December 2003. Field-collected insects that died in the laboratory\\u000a were individually maintained in moist chamber and incubated at 22 °C. Triatominae adults infected with the fungus Paecilomyces lilacinus were found at El Quebracho (27°34?S–64°31?W), Santiago del Estero province, Argentina, in December

Gerardo A. Marti; Claudia C. López Lastra; Sebastian A. Pelizza; Juan J. García



[Orientamento religioso e disturbi del comportamento alimentare].  


riassunto. Introduzione. L'obiettivo principale del presente studio caso-controllo è stato quello di valutare le relazioni intercorrenti tra la psicopatologia dei disturbi del comportamento alimentare (DCA) con il differente orientamento religioso: intrinseco ed estrinseco. Metodi. Sono stati confrontati un gruppo di pazienti affetti da DCA (23 con anoressia nervosa, 10 con bulimia nervosa e 39 con disturbo d'alimentazione incontrollata) con un gruppo di controllo di soggetti sani, utilizzando la Religious Orientation Scale (ROS). Risultati. I pazienti affetti da DCA hanno mostrato punteggi più alti nella sottoscala della religiosità estrinseca e minori punteggi nella sottoscala riguardante la religiosità intrinseca rispetto ai controlli sani. Nessuna differenza significativa è stata osservata tra i gruppi di DCA in termini di punteggi ROS. Conclusioni. Punteggi più elevati riscontrati in pazienti con orientamento religioso estrinseco sembrano essere associati con la presenza di DCA, mentre un orientamento religioso di tipo intrinseco sembra rappresentare un fattore protettivo. PMID:25000890

Castellini, Giovanni; Zagaglioni, Alice; Godini, Lucia; Monami, Francesca; Dini, Carla; Faravelli, Carlo; Ricca, Valdo



Del Norte means north to recycling  

SciTech Connect

Del Norte Regional Recycling and Transfer Station is owned by the city of Oxnard, California and operated by BLT Enterprises, Inc. The Del Norte facility--located in southwestern Ventura County about an hour northwest of Los Angeles--processes polyethylene terephthalate (PET) and high-density polyethylene (HDPE) plastic containers, aluminum, steel, glass, old corrugated containers (OCC), newspapers, computer printout paper, white and colored ledger paper, coated book, supermix paper, telephone books, and old magazines. According to the company, there has been virtually no community opposition to the site. The facility has few neighbors, and those are agricultural. To keep the community relationship strong, the facility`s design and location all but eliminated odor and noise complaints. The building was designed against the prevailing wind pattern, and BLT processes odorous material fast. A misting system installed for dust suppression also can be used with a solution for odor control should the need arise.

Aquino, J.T.



Enfoques de programación matemática fuzzy multiobjetivo para la planificación operativa del transporte en una cadena de suministro del sector del automóvil = Fuzzy Multiobjective Mathematical Programming Approaches for Operational Transport Planning in an Automobile Supply Chain  

Microsoft Academic Search

En este trabajo se presenta un modelo de programación matemática fuzzy multiobjetivo para la planificación del transporte a nivel operativo en una cadena de suministro. Los objetivos del modelo propuesto son la minimización del número de camiones utilizados y del inventario total, considerando como parámetro borroso las capacidades de los vehículos empleados. Se propone una metodología de resolución para transformar

Manuel Díaz-Madroñero; David Peidro; Josefa Mula; Francisco J. Ferriols




Microsoft Academic Search

El sistema para gestionar la actividad científica del Departamento de Informática de la Universidad de Guantánamo surge debido a la necesidad de gestionar de manera más rápida, segura y eficaz los procesos que se desarrollan actualmente en dicho centro. Fue desarrollado utilizando los lenguajes PHP del lado del servidor con CodeIgniter como framework y JavaScript del lado del cliente. Se

Denis Boizan Romero



Epidemiologia della malattia dell'Occhio Secco: Rapporto del Sottocomitato Epidemiologia del Workshop Internazionale dell'Occhio Secco (2007) Epidemiologia  

Microsoft Academic Search

Il rapporto del Sottocomitato Epidemiologia del Workshop dell'Occhio Secco del 2007 riassume le cono- scenze attuali dell'epidemiologia della malattia dell'occhio secco, fornendo i dati di prevalenza e incidenza derivanti da varie popolazioni. Mette in risalto la necessità di allargare gli studi epidemiologici a ulteriori aree geografiche, di incorpo- rare varie razze ed etnie negli studi futuri e di determinare un

Sottocomitato Epidemiologia; Janine A. Smith; Julie Albeitz; Carolyn Begley; Barbara Caffery; Kelly Nichols; Debra Schaumberg; Oliver Schein


Descripción del funcionamiento del mercado secundario de bonos soberanos locales en Chile  

Microsoft Academic Search

En este trabajo se describe el funcionamiento del mercado secundario de los bonos de largo plazo soberanos locales. Más específicamente, se describen en profundidad los agentes involucrados, los instrumentos transados y los tipos de plataformas existentes. A partir de este trabajo es posible obtener las siguientes conclusiones. Primero, existe un alto grado de segmentación en el mercado secundario de renta

Sergio D’Acuña; Sergio Godoy; Nicolás Malandre



Eficiencia y determinantes del funcionamiento del mercado paralelo de divisas en Colombia  

Microsoft Academic Search

El presente trabajo analiza la relación entre el tipo de cambio negro y el oficial, al igual que la eficiencia del mercado paralelo de divisas en Colombia. Con base en datos mensuales para el período 1970-1989, se encontró que la tasa de cambio oficial y paralela estaban cointegradas, lo cual implica que el dólar oficial y el negro mantuvieron una

Santiago Herrera



Ajuste estructural y mercado del trabajo: Nigeria después de la crisis del petróleo  

Microsoft Academic Search

En este artículo examinamos la experiencia de Nigeria durante la crisis petrolera de los años 1980 y el comienzo de la aplicación de un paquete de ajuste estructural. Nuestro análisis se concentra en el rol jugado por el mercado del trabajo, particularmente en relación a la situación de empleo y desempleo, como también a los flujos migratorios despertados por la

Paul Collier; Luis Riveros


Mujeres en ascenso: dinámica del sistema educativo y del mercado laboral en Colombia, 1900-2000  

Microsoft Academic Search

El objetivo principal de la presente investigación es describir y analizar los cambios en la transmisión de conocimiento en los establecimientos educativos femeninos de Bogotá y la participación de la mujer dentro del mercado laboral bogotano. Con base en los resultados que arrojó la Encuesta de empleo de 1963-1970 para Bogotá y la Encuesta Integrada de hogares 2006, se elaboró

María del Pilar López-Uribe; Diana Quintero Castellanos; Loly Aylú Gaitán Guerrero



La quimera del mezzo termine. La contribución franco-británica a la caída del liberalismo peninsular  

Microsoft Academic Search

En 1823, en un contexto marcado por el temor a despertar del fantasma de la revolución en Europa, pasó a un primer plano la posibilidad de ensayar en la Península fórmulas moderadas de organización política, un mezzo termine que conjugara la renuncia a los principios más revolucionarios con el reconocimientos de ciertos derechos y garantías individuales. El debate creado en

Gonzalo Butrón Prida



Boletín del Instituto Nacional del Cáncer - 11 de septiembre de 2012

Con la ayuda de herramientas genéticas, investigadores han identificado subconjuntos de células que parecen impulsar el crecimiento de tumores en ratones. Estos resultados ofrecen factores adicionales que sustentan la hipótesis de la existencia de células madre del cáncer, es decir, la idea de que algunos tumores contienen células que se autorenuevan y dan origen a todo tipo de células tumorales.


Diseño del saneamiento de Urdaibai (País Vasco) bajo una perspectiva de preservación ambiental del litoral  

Microsoft Academic Search

Los sistemas de saneamiento unitarios, del mismo modo que cualquier obra de infraestructura dispuesta a soportar fenómenos naturales, pre- sentan, inevitablemente, una determinada probabilidad de fallo, igual, a la de que los efectos producidos por estos superen a los considerados en su diseño. Por tanto, el comportamiento general de los mismos sólo puede evaluarse en términos probabilísticos. Siendo la lluvia



Alcune osservazioni sulle cause di tenuta del settore del franchising nelle fasi recessive  

Microsoft Academic Search

La ricerca esamina le imprese che operano in franchising attraverso microdati raccolti da Assofranchising, la principale associazione italiana nel campo del franchising. Mediante tecniche esplorative e multivariate si dimostra che, ceteris paribus, un aumento della scala delle reti, basata sulla crescita delle risorse umane e materiali, ha un effetto positivo sull’efficienza aziendale attraverso il miglioramento di indicatori strategici di produttività.

Antonio Bernardi



Tratamiento adyuvante del carcinoma de recto  

Microsoft Academic Search

Resumen\\u000a Objectivo  Neustro objetivo es analizar los resultados del tratamiento adyuvante en pacientes operados por un carcinoma rectal localmente\\u000a avanzado, tratados con radioquimioterapia concomitante o secuencial.\\u000a \\u000a \\u000a \\u000a Material y métodos  Entre enero de 1994 y septiembre de 1997, 122 pacientes fueron tratados postquirúrgicamente por un adenocarcinoma rectal en\\u000a estadio B2-C. Setenta y siete pacientes fueron tratados siguiendo un esquema alternante de quimiorradioterapia y

Javier Valencia Julve; Ricardo Escó Barón; Javier Sanz Lacalle; Miguel Burillo Cordero; Pedro Mateo de las Heras; Carmen Lainez Baquero



UBVJHKLM photometry of Nova Del 2013  

NASA Astrophysics Data System (ADS)

We present the results of the optical and IR photometry of Nova Del 2013 obtained at the Crimean Station (Nauchny, Ukraine) of the Sternberg Astronomical Institute. UBV photometry was carried out with 60-cm Zeiss telescope using a photoelectric photometer on August 15.94 UT: U=4.54+/-0.02, B=5.07+/-0.01, V=5.05+/-0.01; on August 16.80 UT: U=4.54+/-0.01, B=4.85+/-0.02, V=4.68+/-0.01; on August 16.86 UT: U=4.66+/-0.01, B=4.92+/-0.01, V=4.73+/-0.01.

Burlak, A. M.; Shenavrin, I. V.; Tatarnikov, M. A.; Tatarnikova, A. A.




Microsoft Academic Search

Este tema presenta un conjunto de cuestiones relacionadas con las transformaciones históricas más recientes del trabajo y del empleo. Intentaremos aquí seguir su trayectoria en la segunda mitad del siglo XX para poder analizar las tendencias más recientes del mercado de trabajo que se proyectan hacia el siglo XXI y que sirven de contexto y de marco de explicación al

Antonio Santos Ortega



Microsoft Academic Search

Con este trabajo pretendemos acercarnos al Carnaval de Andalucía occidental a partir de su recuperación durante la Transición y los gobiernos socialistas en la década de los años ochenta del pasado siglo XX. Este proceso tuvo lugar en un marco de participación ciudadana, modernización económica, estado del bienestar, constitución de las comunidades autónomas, sociedad del espectáculo y del entretenimiento, y

Francisco José García Gallardo



Instantánea de los cánceres de cerebro y del sistema nervioso central

Información sobre las tendencias de incidencia, mortalidad y financiamiento del NCI sobre los cánceres de cerebro y del sistema nervioso central; así como ejemplos de actividades del NCI y adelantos en la investigación de estos tipos de cáncer.


Decoding F508del Misfolding in Cystic Fibrosis  

PubMed Central

The functional deficiency of the cystic fibrosis transmembrane conductance regulator (CFTR), a plasma membrane chloride channel, leads to the development of cystic fibrosis. The deletion of a phenylalanine at residue 508 (F508del) is the most common cause of CFTR misfolding leading to the disease. The F508del misfolding originates in the first nucleotide-binding domain (NBD1), which induces a global conformational change in CFTR through NBD1’s interactions with other domains. Such global misfolding produces a mutant chloride channel that is impaired in exocytic trafficking, peripheral stability, and channel gating. The nature and atomic details of F508del misfolding have been subject to extensive research during the past decade. Current data support a central role for NBD1 in F508del misfolding and rescue. Many cis-acting NBD1 second-site mutations rescue F508del misfolding in the context of full-length CFTR. While some of these mutations appear to specifically counteract the F508del-induced misfolding, others release certain inherent conformational constraints of the human wild-type CFTR. Several small-molecule correctors were recently found to act on key interdomain interfaces of F508del CFTR. Potential rational approaches have been proposed in an attempt to develop highly effective small molecule modulators that improve the cell surface functional expression of F508del CFTR.

Wang, Xiaodong Robert; Li, Chenglong



Conceptos fundamentales del desarrollo de proveedores (Caso de negocios 13)  

Microsoft Academic Search

El desarrollo de proveedores es una actividad que enriquece la gestión de la cadena de suministro, dotándola de mayor valor a través del aporte mutuo entre empresas clientes y subcontratistas. Este aporte incluye nuevas tecnologías, know-how, herramientas de la calidad y organización del trabajo, además de negociaciones sobre la política de precios, entre otros temas. En este trabajo presentamos sus

Enrique Yacuzzi



Fomento de la investigación del cáncer en América Latina

La Oficina para el Desarrollo de Programas de Cáncer en América Latina (OLACPD), fruto de una alianza innovadora entre el Instituto Nacional del Cáncer (NCI) y el Centro Internacional Fogarty (FIC), fue creada en reconocimiento de la oportunidad de apoyar y mejorar la investigación y el tratamiento del cáncer en América Latina.


El presidente Obama anuncia nombramiento del doctor Harold Varmus

En los últimos cinco años como director del NCI, y en otras funciones ejercidas durante muchos años, he disfrutado ampliamente cada oportunidad que he tenido de visitar los laboratorios y las oficinas, desde Bethesda hasta Frederick, para conocer en persona a los miembros del personal y compartir mis opiniones sobre temas importantes en torno a la ciencia y al manejo de este gran Instituto.


El sistema muscular es el impulsor del desarrollo esquelético  

Microsoft Academic Search

ExtractoEn esta revisión se abordan los conceptos metodológicos de evaluación de la función de la musculatura esquelética y adaptación ósea. Actualmente se considera que la propiedad crítica del hueso no es tanto su peso como su resistencia, y que el control de la resistencia ósea se ejerce principalmente a través del efecto de las cargas mecánicas que inciden sobre el

Eckhard Schoenau



The hydrothermal system of Nevado del Ruiz volcano, Colombia  

Microsoft Academic Search

Hot springs and steam vents on the slopes of Nevado del Ruiz volcano provide evidence regarding the nature of hydrothermal activity within the summit and flanks of the volcano. At elevations below 3000 m, alkali-chloride water is discharged from two groups of boiling springs and several isolated warm springs on the western slope of Nevado del Ruiz. Chemical and isotopic

Neil C. Sturchio; Stanley N. Williams; Nestor P. Garcia; Adela C. Londono



Gestión ambiental de la vitivinicultura: aplicación del cuadro de mando  

Microsoft Academic Search

Resumen La vitivinicultura es una de las principales industrias de San Juan, Argentina. En esta provincia existen más de 266 bodegas. Actualmente, existe mayor conciencia, por parte del consumidor, del proceso de elaboración de un producto, desde el punto de vista medioambiental, sobre todo en países como Estados Unidos y el Reino Unido, los cuales son los principales países importadores

Rosa Ana Rodríguez; Gustavo R. Traconis



An Accretion Disc Model For Eclipsing Binary System: AV Del  

Microsoft Academic Search

We investigate the light and radial-veloci -ty curves of the eclipsing binary AV Del. Using the most new version of Wilson & Van Hamme (2003) code, the absolute elements, fundamental orbital and physical parameters of the system are determined. Then, using the new SHELLSPEC code, we study and present an accretion disc model for the system. We found AV Del

Sayyed Mohammad Reza Ghoreyshi; Jamshid Ghanbari; Fatemeh Salehi


Molecular basis of DEL phenotype in the Chinese population  

PubMed Central

Background Rh blood group system is the most complex and immunogenetic blood group system. Prevalent RHD alleles vary in different populations. We conducted the present study to examine the genotype of DEL individuals and to elucidate whether novel alleles exist in the Chinese population. Methods DEL phenotype was identified by a serologic adsorption-elution method. The nucleotide sequences of ten RHD exons and exon-intron boundary regions were evaluated by RHD gene-specific PCR-SSP and sequencing. Results Of 42306 samples from individual donors and patients, 165 samples were typed as D-negative. Among these D-negative samples, 41 DEL individuals were observed. Thirty-seven DELs were confirmed to have the RHD1227A allele. Two DELs seemed to have RHD-CE-D hybrid alleles, including one RHD-CE (4–7)-D and one RHD-CE (2–5)-D. Two novel RHD alleles were found among the rest of the DEL samples, including one RHD93T?>?A and one RHD838G?>?A. Conclusion In this study, about 24.85% (41/165) of the apparent D-negative Chinese individuals were DEL. RHD1227G?>?A is the most frequent allele in Chinese DEL phenotypes, accounting for 90.24% (37/41). The RHD-CE-D hybrid allele might be the second most frequent DEL allele in the Chinese population. Our study would contribute to the understanding of the molecular mechanism underlying D antigen expression of DEL individuals and provide useful information for designing suitable genotyping strategies in RhD-negative individuals in Asia.



El Instituto Nacional del Cáncer de EE. UU. y la República del Perú firman una Declaración de Intención

El Instituto Nacional del Cáncer y la República del Perú firmaron una declaración de intención para compartir el interés en fomentar la investigación biomédica de oncología, basándose en la colaboración mutua de ambas entidades, así como el objetivo común de educar y capacitar la futura generación de científicos y clínicos en investigación oncológica.


La dimensione del tumore è predittiva della sopravvivenza nel tumore del polmone non a piccole cellule in stadio IA  

Microsoft Academic Search

Oggetto dello studio: La premessa base dello screening mediante TC è che la dimensione sia una determinante importante della sopravvivenza per il cancro del polmone. Noi abbiamo cer- cato di esaminare questa ipotesi per il tumore del polmone non a piccole cellule (NSCLC) in stadio IA. Metodi: È stata condotta una analisi retrospettiva di tutti i pazienti con NSCLC istologicamente

Jeffrey L. Port; Michael S. Kent; Robert J. Korst; Daniel Libby; Mark Pasmantier; Nasser K. Altorki



[Strengths and future of the Revista Médica del Instituto Mexicano del Seguro Social].  


The journals of medicine arose as a communication tool more than 200 years ago. At the beginning, their nature was local; later, their aim was to spread medical information along the nation; and, finally, they sought to reach the world distribution. The Revista Médica del Instituto Mexicano del Seguro Social was published for the first time 52 years ago, and it has walked its way from local to international distribution. This journal has 23 000 subscribers, it is included in Medline and it reached a 0.112 SCImago Journal Rank in 2012. Its website receives around 200 000 visits monthly and 45 % are foreign visits. In the future, the peer review system is going to be strengthened, and the journal is going to offer audio, video, and applications to reinforce interactive participation between authors, readers in order to reach modernity and draw young new attention. PMID:24758842

Fajardo-Dolci, Germán



El metabolismo social del País Vasco desde el análisis de flujos materiales  

Microsoft Academic Search

La desvinculación de la mejora del bienestar respecto del uso de los recursos y de la contaminación es esencial para lograr un desarrollo sostenible. Para avanzar en esta dirección es preciso partir del conocimiento del metabolismo de la sociedad. Es decir, debemos analizar en qué medida nuestras sociedades “ingieren” materias primas, que son “metabolizadas” para producir bienes y servicios, y

Iñaki Arto



La teoría de juegos conductual, el dilema del viajero alternativo y la maximización de pagos  

Microsoft Academic Search

Dentro del área de teoría de juegos conductual nos enfocamos en un contexto específico, el del juego que denominamos Dilema del viajero alternativo. En este contexto hemos observado que los participantes tienden a elegir estrategias estrictamente dominadas. Para explicar tendencias similares en otros juegos, los investigadores del área han apelado a sesgos cognitivos o bien a factores motivacionales. Proponemos un

Rodrigo Moro; Esteban Freidin; Fernando Tohmé; Marcelo Auday


Doctor Harold Varmus, director del NCI: Bienvenidos a en español

El director del NCI, doctor Harold Varmus, da la bienvenida a los visitantes al sitio web del NCI y habla sobre la complejidad del cáncer, así como de los avances alcanzados gracias a las nuevas herramientas y tecnologías para la investigación del cáncer.


Antenatal Rh prophylaxis is unnecessary for “Asia type” DEL women  

Microsoft Academic Search

BackgroundGenerally Rh-negative patients need to be transfused with Rh-negative red blood cells. For pregnant women carrying Rh-positive fetus, the antenatal anti-D detection and Rh immunoglobulin prophylaxis are required worldwide. In East Asia, a RhD variant, termed “Asia type” DEL, was found in approximately 30% of apparent Rh-negative individuals. The antigenic and molecular properties of the DEL were previously defined. Few

Chao-Peng Shao; Hua Xu; Qun Xu; Guo-Dong Sun; Jian-Ping Li; Bo-Wei Zhang; Xiao-Hua Liang; Zhong Liu; Ying Zhou; Dan Li; Nai-Bao Zhuang



Modelo semi-empírico de protuberancia solar a partir del diagnóstico de densidades  

NASA Astrophysics Data System (ADS)

A partir de la observación del espectro del quintuplete de C III alrededor de 1175 Å, se ha realizado el diagnóstico de la densidad y presión electrónica, basado en el cálculo del cociente de las intensidades observadas. Una vez establecida la densidad electrónica, y con el cálculo de las velocidades Doppler, hemos investigado el flujo de masa en la protuberancia en función de la temperatura. Estableciendo como hipótesis la conservación del número de partículas que ingresan y salen del cuerpo de la protuberancia, se investiga la variación del área de un tubo de flujo semi-empírico en función de la temperatura. A partir de dicho diagnóstico, se examina el comportamiento del radio del tubo magnético en función de la temperatura, los que dan cuenta de la abertura de las líneas de campo magnético que confinan el plasma y de la divergencia del campo magnético en diferentes alturas de la atmósfera solar.

Cirigliano, D.; Vial, J. C.; Rovira, M.


Peat soil flows in Bahía del Buen Suceso, Tierra del Fuego (Argentina)  

NASA Astrophysics Data System (ADS)

On the southeastern edge of Tierra del Fuego, a mountainous area with a cold humid oceanic climate, peat soils cover not only flat areas but also steep hillslopes under an evergreen Nothofagus betuloides forest. Peat flows in the form of chutes are very frequent on these hillslopes. Some data were gathered on the field for 11 of these movements and from aerial photographs for 21 of them. The results suggest that peat soils become unstable when thickness exceeds a critical value which depends on the slope. This critical slope depends on the altitude and aspect regardless of soil thickness. A temporal analysis carried out by tree-ring counting demonstrated that the occurrence of these movements is not random though there are some periods of higher hazard, the probable triggering mechanisms being heavy snowfalls or earthquakes.

Gallart, Francesc; Clotet-Perarnau, Núria; Bianciotto, Oscar; Puigdefàbregas, Joan



Análisis del espectro infrarrojo del polvo interestelar asociado con cúmulos globulares y de su evolución temporal  

NASA Astrophysics Data System (ADS)

El trabajo que se presenta investiga la dinámica de las partículas de polvo interestelar eyectadas por estrellas gigantes rojas en un cúmulo globular utilizando simulaciones numéricas de su interacción con el campo gravitatorio y con la radiación electromagnética de las estrellas. Se pretende con ello determinar la distribución espacial de ese material como una función del tiempo en un sistema similar a NGC 104 (47 Tuc). A partir de la distribución espacial resultante se obtuvo el espectro infrarrojo integrado el cual sugiere que el máximo contraste con la radiación estelar ocurre en longitudes de onda cercanas a 300 ?m y que decrece rápidamente hacia longitudes de onda menores, en las que suelen realizarse las observaciones.

Pellizza, L. J.; Forte, J. C.; Carpintero, D.


El diseño final del espectrógrafo de banco (EBASIM) para CASLEO  

NASA Astrophysics Data System (ADS)

Utilizando el código de óptica ACCOS V se ha finalizado el diseño del espectrógrafo de banco para CASLEO. En una comunicación anterior habíamos indicado que utilizaríamos un colimador de 150 mm de diámetro con un radio de curvatura de 1540 mm. Para el espejo cámara, que tiene un diámetro de 200 mm, el radio de curvatura es de 1200 mm, ambos radios con una tolerancia no mayor a los 3 mm. En la presente, se informa sobre los detalles finales del cálculo del espectrógrafo que incluye el cómputo para 5 longitudes de onda diferentes y alrededor de 100 rayos. En todos los casos el 75 % de energía está dentro de un diámetro de 13 micrones. El diseño ha sido probado entre 3500 Å hasta 9000 Å con resultados satisfactorios.

Simmons, J.; Levato, H.



Microsoft Academic Search

RESUMEN Existen múltiples reportes del efecto genotóxico y cancerígeno del cromo VI, los seres humanos tenemos una permanente exposición a este elemento. Objetivos. Evidencias la genotoxicidad del dicromato de potasio utilizando como sistema biológico a Oreochromis niloticus \\

Zulita Prieto; Julio León-Incio; Carlos Quijano-Jara; Radigud Fernández; Edgardo Polo-Benites; Roger Vallejo-Rodríguez; Luis Villegas-Sanchez


Field measurements of del13C in ecosystem respiration  

NASA Astrophysics Data System (ADS)

Stable carbon isotope del13C-measurements are extensively used to study ecological and biogeochemical processes in ecosystems. Above terrestrial ecosystems, atmospheric del13C can vary largely due to photosynthetic fractionation. Photosynthetic processes prefer the uptake of the lighter isotope 12C (in CO2), thereby enriching the atmosphere in 13C and depleting the ecosystem carbon. At night, when ecosystem respiratory fluxes are dominant, 13C-depleted CO2 is respired and thereby depletes the atmospheric del13C-content. Different ecosystems and different parts of one ecosystem (type of plant, leaves, and roots) fractionate and respire with a different del13C-ratio signature. By determining the del13C-signature of ecosystem respiration in temporal and spatial scale, an analysis can be made of the composition of respiratory sources of the ecosystem. A field study at a dry cropland after harvest (province of Viterbo, Lazio, Italy) was performed in the summer of 2013. A FTIR (Fourier Transform Infrared Spectrometer) was set up to continuously measure CO2-, CH4-, N2O-, CO- and del13C-concentrations. The FTIR was connected to 2 different flux measurements systems: a Flux Gradient system (sampling every half hour at 1.3m and 4.2m) and 2 flux chambers (measured every hour), providing a continuous data set of the biosphere-atmosphere gas fluxes and of the gas concentrations at different heights. Keeling plot intercept values of respiratory CO2, measured by the Flux Gradient system at night, were determined to be between -25‰ and -20‰. Keeling plot intercept values of respiratory CO2, measured by the flux chamber system, varied between -24‰ and -29‰, and showed a clear diurnal pattern, suggesting different (dominant) respiratory processes between day and night.

van Asperen, Hella; Sabbatini, Simone; Nicolini, Giacomo; Warneke, Thorsten; Papale, Dario; Notholt, Justus



El doctor Varmus dirigirá una institución "inigualable", afirma el director del NCI, doctor John Niederhuber

En un mensaje dirigido al personal del Instituto Nacional del Cáncer (NCI) y a quienes se interesan por la oncología, el doctor John Niederhuber, director del NCI, aplaude el nombramiento de Harold Varmus y afirma que esta designación le "dará al NCI un liderazgo fuerte no solo en la institución sino mas allá de ella, así como una voz muy respetada en el Congreso, que abogue por los recursos que son tan necesarios para sostener la misión del Instituto.


Net'aa chonaarãweda nepiripata p’edaa = Tradición oral del pueblo épera  

Microsoft Academic Search

La presencia épera en el Ecuador se remonta a principios de los años sesenta del siglo pasado, cuando pequeñas olas migratorias de indígenas colombianos del Saija llegaron a Ecuador y se asentaron en la región noroccidental de la provincia de Esmeraldas en la costa del Pacífico. Algunas razones para la migración fueron el comercio y la similitud entre su medio

J. Gómez Rendón; W. Poirama; L. Quiroz; B. Chiripua; Y. Capena



Política monetaria y cambios de régimen en los tipos de interés del mercado interbancario español  

Microsoft Academic Search

En este trabajo analizamos el comportamiento dinámico del tipo de interés a un mes del mercado interbancario español entre 1987 y 2001. Se utiliza un proceso de difusión tipo raíz cuadrada que permite que el tipo cambie dependiendo del estado de la economía. El cambio entre regímenes es dirigido por un proceso de Markov de primer orden con probabilidades de

José Luis Fernández-Serrano; M. Dolores Robles Fernández



Política Monetaria y Cambios de Régimen en los tipos de Interés del Mercado Interbancario  

Microsoft Academic Search

En este trabajo analizamos el comportamiento dinámico del tipo de interés a un mes del mercado interbancario español entre 1987 y 2001. Se utiliza un proceso de difusión tipo raíz cuadrada que permite que el tipo cambie dependiendo del estado en el que se encuentre la economía. El cambio entre regímenes es dirigido por un proceso de Markov de primer

José Luis Fernández Serrano; Dolores Robles Fernández



Estudio Hidrológico del río Arlanzón a su paso por el Término Municipal de Burgos  

Microsoft Academic Search

Para la ordenación del territorio en el Término Municipal de Burgos se necesita conocer el riesgo de inundación por las aguas de los ríos Arlanzón, Vena, Cardeñadijo y Ubierna. Por ello, se ha realizado un estudio hidrológico de la cuenca del Arlanzón partiendo de los datos de precipitaciones, cartografía referente a usos del suelo, edafología, geología y topografía, fotografías aéreas




Microsoft Academic Search

Resumen. En este artículo se analiza el comportamiento del hormigón a un nivel mesomecánico de observación bajo cargas de tracción uniaxial dependientes del tiempo. Como punto de partida se ha empleado un modelo mesoestructural en 2D para materiales heterogéneos basado en elementos junta de espesor nulo, desarrollado dentro del grupo de investigación de la ETSECCPB-UPC. En este modelo, la estructura

Ricardo Lorefice; Guillermo Etse; Carlos M. López; Ignacio Carol


Interdisciplinary Unit: La Isla del Encanto (The Enchanted Island).  

ERIC Educational Resources Information Center

This document presents a series of 14 lesson plans in an interdisciplinary Spanish unit on "La isla del encanto/The Enchanted Island." The materials were prepared for students in grades 5 or 6 who have had basic Spanish instruction in previous grades. The students should also be familiar with basic concepts in English such as math computation, map…

Ford-Guerrera, Rebecca


Regulaciones del mercado laboral: un estudio comparativo entre países  

Microsoft Academic Search

En este trabajo se analizan tres tipos de instituciones prevalecientes en los mercados laborales de muchos países, normas sobre salario mínimo, introducción de costos no salariales (prestaciones complementarias) y las políticas de salario y empleo del gobierno. Se sostiene que estos tres son los aspectos estratégicos a analizar en el caso de los países en desarrollo con respecto a las

Peter R. Fallon; Luis Riveros


Estimación endógena del repudio en mercados soberanos de crédito  

Microsoft Academic Search

En vista de la falta de fundamentos teóricos en la bibliografía relacionada con el repudio en los mercados soberanos de crédito, se construye un modelo que considera todas las peculiaridades de los mercados internacionales de crédito. En particular, se incluye la idea de sanciones en el caso de repudio. Del modelo se extraen diversas conclusiones que contrastan con lo existente.

Fausto Hernández Trillo



Del Mod: A State-Wide System for School Improvement.  

ERIC Educational Resources Information Center

This is a retrospective account of the Del Mod System, a statewide project to improve science and mathematics education in the elementary and secondary schools of Delaware. The project functioned from 1970-76 under the auspices of a committee including the presidents of institutions of higher education, the state superintendent of public…

Neale, Daniel C.


Advances in optical technologies at Pontificia Universidad Católica del Perú  

NASA Astrophysics Data System (ADS)

In this work, it is shown a panoramically view of advances and works on fundamental optical technology developed and Physics Section at Pontificia Universidad Católica del Perú PUCP in Lima Peru. This includes works in, precision optics manufacturing, optical testing, and optical design and simulation and also in optical thin film evaporation and its design techniques

Baldwin, Guillermo; Asmad, Miguel; Romero, Sandra; Gonzales, Franco; Gálvez, Gonzalo; Sánchez, Rubén; Córdova, Darwin



Tratamiento del paludismo pediátrico: Papel de las intervenciones nutricionales  

Microsoft Academic Search

ResumenEl paludismo es una causa primordial de morbilidad y mortalidad en niños, particularmente en África subsahariana. Aunque se ha logrado un progreso considerable en el tratamiento del paludismo pediátrico con el tratamiento de combinación basado en la artemisinina, siguen existiendo numerosos obstáculos que se oponen a la puesta en práctica efectiva de estas nuevas opciones terapéuticas sumamente eficaces. Análogamente, si

Akoto Kwame Osei; Davidson H. Hamer



Medical Ethnobotany of the Teribes of Bocas del Toro, Panama  

Microsoft Academic Search

Ethnomedical uses of 108 medicinal plant species, belonging to 52 families, 89 genera, used by the Teribe Amerindians of Bocas del Toro Province in Panama, along with their socio-cultural practices are reported here. The methods of administration of the herbal remedies, the plant parts used, their families and local names are also documented. The recorded medicinal plants were used mainly

M. P. Gupta; P. N. Solís; A. I. Calderón; F. Guinneau-Sinclair; M. Correa; C. Galdames; C. Guerra; A. Espinosa; G. I. Alvenda; G. Robles; R. Ocampo



Aspetti evolutivi del sistema agro-alimentare in Algeria  

Microsoft Academic Search

Aspetti evolutivi del sistema agro-alimentare in Algeria (di Antonio Guariglia) - ABSTRACT: Even if it’s estimated that Algeria has potentially around 39 millions hectares of cultivable grounds, at present, the SAU is estimated equal to only 8 millions hectares (3% of territorial surface) situated in the almost totality along the fruitful and narrow coastal plan, while around 31 thousand hectares

Antonio Guariglia



Regional geoid determination in Tierra del Fuego including GPS levelling  

Microsoft Academic Search

A regional geoid model for the Argentine part of the Isla Grande de Tierra del Fuego, established in previous works on the basis of GPS levelling, suffers a lack of observation data in the remote south-western investigation area. In order to improve the data distribution in this region, the mean lake level of Lago Fagnano has been regarded as a

Daniel del Cogliano; Reinhard Dietrich; Andreas Richter; Raúl Perdomo; José Luis Hormaechea; Gunter Liebsch; Mathias Fritsche



Geological and Geophysical Investigations at Sierra del Medio Massif - Argentine.  

National Technical Information Service (NTIS)

Geological investigations were performed at Sierra del Medio (Chubut Province), a mountainous massif of about 25 km by 8 km of migmatic origin, which emerges from a depressed tectonic trench or graben called Pampa de Gastre. The most ancient rocks belong ...

J. C. Perucca E. Llambias H. H. Puigdomenech E. Cebrelli C. E. Castro



The mercury clock of the Libros del Saber  

Microsoft Academic Search

The Libros del Saber de Astronomia is a compilation of various Arabic astronomical works translated into Castilian in the second half of the thirteenth century, under the direction of King Alfonso X of Spain. A section describing a mercury clock has been suggested to be of particular significance in view of the likely invention of the mechanical clock around this

A. A. Mills



Políticas Española e Italiana según la Directiva Marco del Agua  

Microsoft Academic Search

RESUMEN Se ha elaborado un análisis de la evolución de la política internacional y europea, en relación a la gestión de los recursos hídricos, para identificar y comparar principios, objetivos y métodos de actuación en dos países mediterráneos miembros de la Unión Europea: Italia y España. La comparativa obtenida se hace tomando como referencia esencial la Directiva Marco del Agua,

Luis Miguel Valenzuela Montes; Anna Rigossi




Microsoft Academic Search

espacios abstractos, llamados hoy espacios de Hilbert, sería la base ,matemática de la ,Mecánica Cuántica. Esta situación contrasta con la del siglo XVII, en que Newton se vió obligado a desarrollar por sí mismo el cálculo diferencial para hacer convincentes las conclu- siones de los Principia, en tanto que a Hilbert le parecía que esfuerzos de este ,tipo ya no




Microsoft Academic Search

Nella fascia montana della nostra Regione la coltivazione delle specie frutticole minori è stata introdotta negli anni '80 come atti- vità agricola alternativa per diversificare le produzioni e come possibile integrazione al reddito per le aree marginali. Tra le diverse specie coltivate si annovera anche il mirtillo gigante (Vaccinium corymbosum L.). I fiori del mirtillo, di forma urceola- ta, sono

D. Prodorutti; F. Frilli; P. A. Belletti


Faculty Activity Analysis in the Universidad Tecnica Del Estado Campuses.  

ERIC Educational Resources Information Center

An analysis of academic activities of college faculty at the eight campuses of Chile's Universidad Tecnica del Estado was conducted. Activities were grouped into seven categories: direct teaching, indirect teaching, research, community services, faculty development, academic administration, and other activities. Following the narrative…

Karadima, Oscar


Se lanza Red Nacional de Estudios Clínicos del NCI

El Instituto Nacional del Cáncer (NCI) puso en marcha una nueva red de investigación de estudios clínicos con el objetivo de mejorar el tratamiento de más de 1,6 millones de estadounidenses que reciben un diagnóstico de cáncer cada año.


Cosmogenic Radionuclides in the Campo Del Cielo Iron Meteorite  

NASA Technical Reports Server (NTRS)

Cosmogenic Be-10, Al-26, Cl-36, Ca-41, and Ni-59 were measured in the Campo del Cielo iron meteorite. Our results led us to conclude that the pre-atmospheric radius might have been approximately 2 m. Comparisons with other big bodies are also presented. Additional information is contained in the original extended abstract.

Liberman, R. G.; FernandezNiello, J. O.; Reedy, R. C.; Fifield, L. K.; diTada, M. L.



Efecto del Programa de Entrenamiento "Manejo del Dolor" en la Documentaci?n de Enfermer?a en el Expediente Electr?nico  

PubMed Central

Resumen En el presente trabajo se muestra la importancia de entrenar al personal de enfermería para mejorar la documentación en el expediente electrónico. Se eligió el manejo del dolor por ser un área prioritaria; una alta proporción de pacientes en período post operatorio cursa con dolor, por lo tanto, la documentación debe ser útil para la toma de decisiones clínicas. Se implementó un programa de entrenamiento denominado “Manejo del Dolor” dirigido al personal de enfermería. Se utilizó la tecnología de la información como herramienta para fortalecer el conocimiento con base en la revisión sistemática de la literatura; el personal de enfermería participante seleccionó la mejor evidencia; posteriormente se trabajó en la transferencia de este conocimiento a la práctica a través del diseño de un protocolo para el manejo del dolor. Se concluye que el conocimiento del manejo del dolor es fundamental para que enfermería documente con mayor precisión sus intervenciones.

Monsivais, Maria Guadalupe Moreno; Guzman, Ma. Guadalupe Interial; Flores, Paz Francisco Sauceda; Arreola, Leticia Vazquez



Molecular and cytogenetic characterization of del(9p) syndrome  

SciTech Connect

The del(9p) syndrome is characterized by mental retardation, trigonocephaly, midface hypoplasia, upward slanting palpebral fissures, a long philtrum, and is typically associated with a breakpoint at 9p22. Seventeen unrelated patients with del(9p) and their parents were analyzed by high resolution chromosome studies, molecular analysis using a series of highly polymorphic dinucleotide repeat markers for 9p, and fluorescence in situ hybridization (FISH) to characterize precisely the extent of chromosome loss. Eleven patients were found to have an interstitial deletion with breakpoints assigned to 9p22.1 and 9p24.3 in most cases. Two patients had familial unbalanced translocations of maternal origin and four had de novo complex rearrangements identified by high resolution analysis and FISH utilizing chromosome libraries. PCR analysis of eleven families with eight minisatellite markers determined paternal origin of the deletion in six cases and maternal origin in five. This suggests that the molecular event resulting in the deletion is equally prevalent in both male and female gametogenesis and that genomic imprinting does not play a role in the pathogenesis of del(9p) syndrome. Increased precision in mapping these minisatellite markers was also possible through this work. This study demonstrates the existence of molecular heterogeneity as six patients with a cytological breakpoint at 9p22.1 revealed three different molecular breakpoints. These findings suggest that genotype-phenotype correlations in deletion syndromes such as this should be based on high-resolution molecular analysis of the deleted chromosome segment. Work is in progress to map a series of cosmid probes by FISH relative to chromosomal breakpoints in these patients. These combined studies should provide a better understanding of the mechanisms involved in the pathogenesis of del(9p) syndrome and may identify loci where genes responsible for one or more aspects of the del(9p) phenotype may reside.

Micale, M.A.; Haren, J.M.; Schwartz, S. [Case Western Reserve Univ. School of Medicine, Cleveland, OH (United States)] [and others



Moléculas orgánicas obtenidas en simulaciones experimentales del medio interestelar.  

NASA Astrophysics Data System (ADS)

Las nubes moleculares son regiones de formación de estrellas, con temperaturas cinéticas entre 10-50 K y densidades de 103-106 átomos cm-3. Su materia está formada por gas y polvo interestelar. Estas partículas de polvo están cubiertas por una fina capa de hielo, de unos 0.01 ?m, que contiene H2O y a menudo CO, CO2, CH3OH y NH3. El hielo es presumiblemente irradiado por fotones ultravioleta y rayos cósmicos en las zonas poco profundas de las nubes moleculares y las regiones circunestelares. En un sistema de vacío, P ˜ 10-7 mbar, simulamos la deposición de hielo a partir de 10 K y la irradiación ultravioleta por medio de una lámpara de descarga de hidrógeno activada con microondas. La evolución del hielo se observa por medio de un espectrómetro infrarrojo. De este modo es posible determinar la composición del hielo observado en el medio interestelar y predecir la presencia de moléculas aún no detectadas en el espacio, que han sido producto del procesamiento del hielo en nuestros experimentos. También es posible calentar el sistema hasta temperatura ambiente para sublimar el hielo depositado. Cuando el hielo ha sido previamente irradiado, se observa un residuo compuesto por moléculas orgánicas complejas, algunas prebióticas, como varios ácidos carboxílicos, aminas, amidas, ésteres y en menor proporción moléculas heterocíclicas y aminoácidos. Algunas de estas moléculas podrían detectarse en estado gaseoso por medio de observaciones milimétricas y de radio. También podrían estar presentes en el polvo cometario, cuyo análisis químico está planeado por las misiones Stardust y Rosetta. Mientras tanto, nuestro grupo está llevando a cabo el análisis de partículas de polvo interplanetario (IDPs), algunas de las cuales pueden ser de origen cometario. Al igual que ocurre con los productos obtenidos por irradiación del hielo en nuestros experimentos, algunas IDPs son ricas en material orgánico que contiene oxígeno.

Muñoz-Caro, Guillermo Manuel



Microsoft Academic Search

América Latina y el Caribe es la única región en desarrollo que puede acabar con el hambre en nuestra generación. Tiene 52,4 millones de personas subnutridas (10% de población) y 9 millones de niños con desnutrición crónica, pero también es la principal productora mundial de alimentos y tiene recursos financieros, naturales, humanos e institucionales para hacer del hambre un recuerdo

Jose Luis Viveros; Niemeyer Almeida Filho



La democracia constitucional en América Latina y las evoluciones recientes del presidencialismo. Memorias Encuentro del Instituto Iberoamericano de Derecho Constitucional  

Microsoft Academic Search

Siempre será oportuno reflexionar sobre la democracia, su contenido, sus desafíos, su presente y su futuro, las transformaciones y percepciones que de ella se tienen. No son pocas las preocupaciones o inquietudes que la democracia suscita en esta parte del mundo, y muestra de ello son los más variados estudios e informes sobre el estado actual de la democracia y

Pedro Pablo Vanegas


Prognostic Impact of del(17p) and del(22q) as Assessed by Interphase FISH in Sporadic Colorectal Carcinomas  

PubMed Central

Background Most sporadic colorectal cancer (sCRC) deaths are caused by metastatic dissemination of the primary tumor. New advances in genetic profiling of sCRC suggest that the primary tumor may contain a cell population with metastatic potential. Here we compare the cytogenetic profile of primary tumors from liver metastatic versus non-metastatic sCRC. Methodology/Principal Findings We prospectively analyzed the frequency of numerical/structural abnormalities of chromosomes 1, 7, 8, 13, 14, 17, 18, 20, and 22 by iFISH in 58 sCRC patients: thirty-one non-metastatic (54%) vs. 27 metastatic (46%) disease. From a total of 18 probes, significant differences emerged only for the 17p11.2 and 22q11.2 chromosomal regions. Patients with liver metastatic sCRC showed an increased frequency of del(17p11.2) (10% vs. 67%;p<.001) and del(22q11.2) (0% vs. 22%;p?=?.02) versusnon-metastatic cases. Multivariate analysis of prognostic factors for overall survival (OS) showed that the only clinical and cytogenetic parameters that had an independent adverse impact on patient outcome were the presence of del(17p) with a 17p11.2 breakpoint and del(22q11.2). Based on these two cytogenetic variables, patients were classified into three groups: low- (no adverse features), intermediate- (one adverse feature) and high-risk (two adverse features)- with significantly different OS rates at 5-years (p<.001): 92%, 53% and 0%, respectively. Conclusions/Significance Our results unravel the potential implication of del(17p11.2) in sCRC patients with liver metastasis as this cytogenetic alteration appears to be intrinsically related to an increased metastatic potential and a poor outcome, providing additional prognostic information to that associated with other cytogenetic alterations such as del(22q11.2). Additional prospective studies in larger series of patients would be required to confirm the clinical utility of the new prognostic markers identified.

Gonzalez-Gonzalez, Maria; Munoz-Bellvis, Luis; Mackintosh, Carlos; Fontanillo, Celia; Gutierrez, M. Laura; Abad, M. Mar; Bengoechea, Oscar; Teodosio, Cristina; Fonseca, Emilio; Fuentes, Manuel; De Las Rivas, Javier



Fair trade, premio di prezzo e fallimenti del mercato  

Microsoft Academic Search

Il premio di prezzo è solo una componente, non marginale, sicuramente la più caratteristica e facilmente comunicabile, ma certamente non decisiva nel modello Fair Trade. L’avere incentrato l’attenzione su questo specifico aspetto del meccanismo complessivo ha nascosto altri aspetti più rilevanti dello schema operativo. Nel presente lavoro si cerca di mostrare come l’impatto maggiore delle strategie di Fair Trade riguarda

A. Arrighetti



The Borexino detector at the Laboratori Nazionali del Gran Sasso  

Microsoft Academic Search

Borexino, a large volume detector for low energy neutrino spectroscopy, is currently running underground at the Laboratori Nazionali del Gran Sasso, Italy. The main goal of the experiment is the real-time measurement of sub-MeV solar neutrinos, and particularly of the monoenergetic (862keV) 7Be electron capture neutrinos, via neutrino–electron scattering in an ultra-pure liquid scintillator. This paper is mostly devoted to

G. Alimonti; C. Arpesella; H. Back; M. Balata; D. Bartolomei; A. de Bellefon; G. Bellini; J. Benziger; A. Bevilacqua; D. Bondi; S. Bonetti; A. Brigatti; B. Caccianiga; L. Cadonati; F. Calaprice; C. Carraro; G. Cecchet; R. Cereseto; A. Chavarria; M. Chen; A. Chepurnov; W. Czech; D. D’Angelo; F. Dalnoki-Veress; A. De Bari; E. De Haas; A. Derbin; M. Deutsch; A. Di Credico; A. Di Ludovico; G. Di Pietro; R. Eisenstein; F. Elisei; A. Etenko; F. von Feilitzsch; R. Fernholz; K. Fomenko; R. Ford; D. Franco; B. Freudiger; N. Gaertner; C. Galbiati; F. Gatti; S. Gazzana; V. Gehman; M. Giammarchi; D. Giugni; M. Goeger-Neff; T. Goldbrunner; A. Golubchikov; C. Grieb; C. Hagner; T. Hagner; W. Hampel; E. Harding; S. Hardy; F. X. Hartmann; R. von Hentig; T. Hertrich; G. Heusser; M. Hult; A. Ianni; An. Ianni; L. Ioannucci; K. Jaenner; M. Joyce; H. de Kerret; S. Kidner; J. Kiko; T. Kirsten; V. Kobychev; G. Korga; G. Korschinek; Yu. Kozlov; D. Kryn; P. La Marche; V. Lagomarsino; M. Laubenstein; C. Lendvai; M. Leung; T. Lewke; E. Litvinovich; B. Loer; F. Loeser; P. Lombardi; L. Ludhova; I. Machulin; S. Malvezzi; A. Manco; J. Maneira; W. Maneschg; I. Manno; D. Manuzio; G. Manuzio; M. Marchelli; A. Martemianov; F. Masetti; U. Mazzucato; K. McCarty; D. McKinsey; Q. Meindl; E. Meroni; L. Miramonti; M. Misiaszek; D. Montanari; M. E. Monzani; V. Muratova; P. Musico; H. Neder; A. Nelson; L. Niedermeier; S. Nisi; L. Oberauer; M. Obolensky; M. Obolensky; F. Ortica; M. Pallavicini; L. Papp; R. Parcells; S. Parmeggiano; M. Parodi; N. Pelliccia; L. Perasso; A. Pocar; R. Raghavan; G. Ranucci; W. Rau; A. Razeto; E. Resconi; P. Risso; A. Romani; D. Rountree; A. Sabelnikov; P. Saggese; R. Saldhana; C. Salvo; R. Scardaoni; D. Schimizzi; S. Schönert; K. H. Schubeck; T. Shutt; F. Siccardi; H. Simgen; M. Skorokhvatov; O. Smirnov; A. Sonnenschein; F. Soricelli; A. Sotnikov; S. Sukhotin; C. Sule; Y. Suvorov; V. Tarasenkov; R. Tartaglia; G. Testera; D. Vignaud; S. Vitale; R. B. Vogelaar; V. Vyrodov; B. Williams; M. Wojcik; R. Wordel; M. Wurm; O. Zaimidoroga; S. Zavatarelli; G. Zuzel



Paradigmas de verbos en el zapoteco del istmo  

Microsoft Academic Search

Varios an?lisis se han hecho o pueden hacerse de las conjugaciones de los verbos en el zapoteco, una familia de lenguas de Oaxaca, M?xico. Marlett y Pickett 1987, siguiendo el an?lisis de Speck 1984, proponen uno para el zapoteco del istmo que hace referencia a un an?lisis de la estructura sil?bica de la lengua. Pickett 1967 presenta otro. Un desaf?o

Isthmus Zapotec; Verb Paradigms



Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

3. 1939 DROP STRUCTURE IN DEL MAR PARK SURMOUNTED BY RECENT PEDESTRIAN BRIDGE. - Highline Canal, Sand Creek Lateral, Beginning at intersection of Peoria Street & Highline Canal in Arapahoe County (City of Aurora), Sand Creek lateral Extends 15 miles Northerly through Araphoe County, City & County of Denver, & Adams County to its end point, approximately 1/4 mile Southest of intersectioin of D Street & Ninth Avenue in Adams County (Rocky Mountain Arsenal, Commerce City Vicinity), Commerce City, Adams County, CO



Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

2. COURSE OF THE LATERAL THROUGH DEL NORTHWEST MAR PARK. - Highline Canal, Sand Creek Lateral, Beginning at intersection of Peoria Street & Highline Canal in Arapahoe County (City of Aurora), Sand Creek lateral Extends 15 miles Northerly through Araphoe County, City & County of Denver, & Adams County to its end point, approximately 1/4 mile Southest of intersectioin of D Street & Ninth Avenue in Adams County (Rocky Mountain Arsenal, Commerce City Vicinity), Commerce City, Adams County, CO


Solar adaptive optics at the Observatorio del Teide, Tenerife  

NASA Astrophysics Data System (ADS)

Observing the Sun with high angular resolution is difficult because the turbulence in the atmosphere is strongest during day time. In this paper we describe the principles of solar adaptive optics exemplified by the two German solar telescopes VTT and GREGOR at the Observatorio del Teide. With theses systems we obtain near diffraction limited images of the Sun. Ways to overcome the limits of conventional AO by applying multiconjugate adaptive optics (MCAO) are shown.

Soltau, Dirk; Berkefeld, Thomas; Schmidt, Dirk; von der Lühe, Oskar



Nuevo sitio web en español del Instituto Nacional del Cáncer, (NCI, por sus siglas en inglés) en español - Silvia Inéz Salazar - transcript

Transmisiones de radio para promover en espa%XF1ol | Nuevo sitio web en espa%XF1ol del Instituto Nacional del C%XE1ncer, (NCI, por sus siglas en ingl%XE9s) en espa%XF1ol | Transcripci%XF3n Transmisiones de radio para promover


Un gobierno alternativo en una región olvidada de Colombia: entrevista al taita Floro Alberto Tunubalái Paja, gobernador del departamento del Cauca  

Microsoft Academic Search

El Departamento del Cauca está situado al Sur de Colombia. En los últimos años ha ocupado el penúltimo lugar en su aporte económico al país. Lós índices de pobreza son grandes, la oferta de trabajo es baja y la desatención y disminución del Estado se acentúa, haciendo cada vez más dificil la solución de las desigualdades sociales que vive la

Diego Jaramillo Salgado



Correction: First high resolution ultraviolet (HST/STIS) and supporting optical spectroscopy of V339 Del = Nova Del 2013  

NASA Astrophysics Data System (ADS)

Due to an error in transcription, the distance is given incorrectly in the text of ATel#5409. Along with the typo "Space Telescope Imaging Spectrograph", the text should read: Comparing these STIS UV spectra with high resolution IUE spectra of the CO nova OS And 1986 obtained between 12 days (LWP) and 22 days (SWP) after optical discovery (1986 Dec. 17, 27 respectively) shows a very close agreement such that when independently dereddened, the ratio of V339 Del to OS And between 1200 and 1900A is ~1.5 in flux (similar in the 2000-3000A range but more uncertain because of the earlier date of the long wavelength IUE observation), indicating that the distance to V339 Del is about 4.2 kpc (distance to OS And ~ 5.1 kpc with E(B-V)=0.25+/-0.05, see Schwarz et al.

Shore, S. N.



The 2012 Reactivation of Nevado del Ruiz Volcano, Colombia  

NASA Astrophysics Data System (ADS)

Nevado Del Ruiz volcano is most known for its tragic November 13, 1985 explosive event, when a small eruption produced an enormous lahar that buried and destroyed the town of Armero in Tolima, causing an estimated 25,000 deaths. Similar but less deadly incidents occurred in 1595 and 1845, again where a small explosive eruption was followed by a large lahar. Other minor explosive events occurred in 1805, 1828-9, and 1989. The Armero tragedy was a major factor in the establishment of a volcano monitoring program in Colombia. The network monitoring Nevado del Ruiz volcano has dramatically improved since the 1985 eruption and now includes geodetic, geophysical, geochemical and visual monitoring. The activity of Nevado Del Ruiz between 1985 and 1991 saw significant increases in seismicity and significant gas emissions with the main eruptive events of November 13, 1985 and September 1st, 1989. The volcano became seismically active again in 1995 and 2002, whit an increase in seismicity, without any gas emission or eruption. In October 2010 the volcano entered in a new phase of unrest with increased seismicity (HB events), deformation and gas emissions, likely associated with a new magma intrusion. In February, 2012 the volcano had a new and significant increase in seismicity (VT-LP), followed in May and June 2012 by small phreatic and phreato-magmatic eruption. This eruptive activity is still ongoing. Deformation measurements at Nevado Del Ruiz volcano have been carried out since just after the tragic eruption of the 13th of November 1985. In 2007 seven new electronic tilt meters were set up to monitor the deformation. Significant uplift was measured from August 2007 to October 2010, for a total cumulative value of more than 500 microradians. From the end of 2011 to July 2012, moderate changes of uplift were detected for a total of 70 microradians. The analysis of these deformation data shows a pattern of surface displacement associated with an intrusion of new magma coming from a reservoir located approximately at a depth of approximately 8 km and accumulating in shallow reservoir less than 2 km beneath the main crater. We fit the data with both a spherical and a vertical spheroid source. The spherical source indicates the existence of an intrusion at a depth of 1823±1056 m with a volume change of (7±17)×106 m3 . The vertical spheroidal source suggests a source 1855 m deep with a volume change of 6×106 m3 . These results imply that while we have strong bounds on the depth of the intrusion, the actual volume of the source is less certain. Gas emission from Nevado del Ruiz volcano in April 7, 2012.

Ordoñez, M.; Lopez, C.; Cortes, G. P.; Londoño, J.; Battaglia, M.



Mutations in TP53 are exclusively associated with del(17p) in multiple myeloma  

PubMed Central

Deletion of the 17p13 chromosomal region [del(17p)] is associated with a poor outcome in multiple myeloma. Most of the studies have targeted the TP53 gene for deletion analyses, although no study showed that this gene is the deletion target. In order to address this issue, we sequenced the TP53 gene in 92 patients with multiple myeloma at diagnosis, 54 with a del(17p) and 38 lacking del(17p). At least one mutation was found in 20 patients, all of them presenting a del(17p). The analysis of the mutation location showed that virtually all of them occurred in highly conserved domains involved in the DNA-protein interactions. In conclusion, we showed that 37% of the myeloma patients with del(17p) present a TP53 mutation versus 0% in patients lacking the del(17p). The prognostic significance of these mutations remains to be evaluated.

Lode, Laurence; Eveillard, Marion; Trichet, Valerie; Soussi, Thierry; Wuilleme, Soraya; Richebourg, Steven; Magrangeas, Florence; Ifrah, Norbert; Campion, Loic; Traulle, Catherine; Guilhot, Francois; Caillot, Denis; Marit, Gerald; Mathiot, Claire; Facon, Thierry; Attal, Michel; Harousseau, Jean-Luc; Moreau, Philippe; Minvielle, Stephane; Avet-Loiseau, Herve



VEGF: A modifier of the del22q11 (DiGeorge) syndrome?  

Microsoft Academic Search

Hemizygous deletion of chromosome 22q11 (del22q11) causes thymic, parathyroid, craniofacial and life-threatening cardiovascular birth defects in 1 in 4,000 infants. The del22q11 syndrome is likely caused by haploinsufficiency of TBX1, but its variable expressivity indicates the involvement of additional modifiers. Here, we report that absence of the Vegf164 isoform caused birth defects in mice, reminiscent of those found in del22q11

Ingeborg Stalmans; Diether Lambrechts; Frederik De smet; Sandra Jansen; Jian Wang; Sunit Maity; Paige Kneer; Maren von der Ohe; Ann Swillen; Christa Maes; Marc Gewillig; Daniel G. M. Molin; Peter Hellings; Thurid Boetel; Maartin Haardt; Veerle Compernolle; Mieke Dewerchin; Stephane Plaisance; Robert Vlietinck; Beverly Emanuel; Adriana C. Gittenberger-de Groot; Peter Scambler; Bernice Morrow; Deborah A. Driscol; Lieve Moons; Camila V. Esguerra; Geert Carmeliet; Annett Behn-Krappa; Koen Devriendt; Désiré Collen; Simon J. Conway; Peter Carmeliet



Efectos derivados de la puesta en pr ctica del marketing de relaciones en los servicios profesionales  

Microsoft Academic Search

El objetivo del presente trabajo es identificar la influencia sobre el consumidor y sobre el resultado empresarial de dos dimensiones b sicas de los servicios profesionales: la dimensi¢n formal o calidad del servicio prestado y la dimensi¢n informal o interacci¢n personal con el cliente. Sobre la base te¢rica del marketing de relaciones, se analiza c¢mo influyen los aspectos formales e

Paolo Freire de Carvalho Filho; Carmen Camarero Izquierdo



Use of Real Time PCR for Rapid Detection of Del Phenotype in Taiwan  

Microsoft Academic Search

During routine serologic procedures, Rh Del blood is often not identified and subsequently labeled as RhD-negative. Recently, several reports have shown the ability of Del blood to induce anti-D in RhD-negative recipients. Among Korean, Japanese, and Chinese, almost all individuals with Del blood have a nucleotide change in the RHD gene of 1227G>A (RHDK407K). Thus, nucleotide 1227A at RHD exon

Chien-Feng Sun; Jui-Ping Liu; Ding-Ping Chen; Wei-Ting Wang; Tyng-Tyng Yang


Els Fragments del Sacramentari de Sant Boi de Lluçanès (Vic. Bib. Espisc., Frag I\\/6)  

Microsoft Academic Search

Els disset folis del manuscrit Vic, Bib. Episc., frag. I\\/6 són les restes d'un sacramentari de tipus gregorià mixt, procedents de la parròquia de Sant Boi de Lluçanès. Foren escrites en l'últim quart del segle X, però, al segon quart del segle XII s'hi feren esmenes adaptant el seu cànon als models d'aquest segle. En això rau la seva singularitat.

Miquel dels Sants Gros i Pujol



Distribución del continuo ultravioleta e infrarrojo en estrellas Be  

NASA Astrophysics Data System (ADS)

Estamos interesados en interpretar los excesos de flujo infrarrojo y/o ultravioleta observados en estrellas Be con respecto al de estrellas B normales, así como su posible correlación. Una envoltura rodeando la estrella distingue una estrella Be de una B normal; para explicar las observaciones es necesario entonces tener en cuenta todos los posibles procesos físicos que en ella tienen lugar. Adoptando un modelo atmosférico específico, hemos estudiado el proceso de recombinación dielectrónica de metales como MgII y FeII, teniendo en cuenta la posible influencia de la opacidad del medio en el flujo emitido.

Cruzado, A.; Ringuelet, A.; di Rocco, H.


How is Shrimp Aquaculture Transforming Coastal Livelihoods and Lagoons in Estero Real, Nicaragua?: The Need to Integrate Social-Ecological Research and Ecosystem-Based Approaches.  


Ecosystem-based approaches to aquaculture integrate environmental concerns into planning. Social-ecological systems research can improve this approach by explicitly relating ecological and social dynamics of change at multiple scales. Doing so requires not only addressing direct effects of aquaculture but also considering indirect factors such as changes in livelihood strategies, governance dynamics, and power relations. We selected the community of Puerto Morazán, Nicaragua as a case study to demonstrate how the introduction of small-scale aquaculture radically transformed another key livelihood activity, lagoon shrimp fishing, and the effects that these changes have had on lagoons and the people that depend on them. We find that shrimp aquaculture played a key role in the collapse, in the 1990s, of an existing lagoon common-property management. Shrimp aquaculture-related capital enabled the adoption of a new fishing technique that not only degraded lagoons but also led to their gradual privatization. The existence of social ties between small-scale shrimp farmers and other community members mitigated the impacts of privatization, illustrating the importance of social capital. Since 2008, community members are seeking to communally manage the lagoons once again, in response to degraded environmental conditions and a consolidation of the shrimp industry at the expense of smaller actors. This research shows that shrimp aquaculture intersects with a complex set of drivers, affecting not only how ecosystems are managed but also how they are perceived and valued. Understanding these social-ecological dynamics is essential to implement realistic policies and management of mangrove ecosystems and address the needs of resource-dependent people. PMID:24912580

Benessaiah, Karina; Sengupta, Raja



Variabilidad del metabolismo oxidativo de fármacos en la población uruguaya Polimorfismo genético del citocromo P-450 2D6  

Microsoft Academic Search

Resumen El estudio ele losj¿7ctores gméticos que determirmr7 la respuesta a los 7~2edictr7i2erzfo.s se demmirm ,fi77.7rlacogerrética. EH la década del 70 se describió el polirnorfïsmo perr&ico dc Iri Llchri.coqLrina-hidroxiiasa. u77 hallazgo de gran r-elevatrcia dado que rnlrclîo.r.f¿í~\\/llcrc,o.c utili:ados cu terapéutica se oxidar? por la misma \\\\jía metahólic~a. Esto e.xpliccr ,grrrrr parte LIP iir var-iahilitiud iudividual que se obset-va en las

Francisco E. Estévez; Marcos Giusti; Susana Parrillo; Miguel Pr-ando



Aparición del cometa Hale - BOPP C / 1995-01  

NASA Astrophysics Data System (ADS)

El Cometa Hale - Bopp fue observado a partir de la 10ma. magnitud con el telescopio de 300mm de abertura a f/6.5. En esas primeras observaciones desde luego no hubo mucho detalle. A su vez las posiciones del cometa para nuestro hemisferio no fueron favorables, solamente asomó por el horizonte N.O. para nuestra latitud cuando se alejaba de la Tierra. Se registró la observación visualmente con binoculares 10 x 50, y fotográficamente con un Telezoom de 210mm a f/4,5 con película 400 ASA color. Todas las imágenes fueron procesadas y digitalizadas a fin de obtener las diferentes escalas de brillo. El aspecto que presentó para nuestra posición geográfica fue discreta ya que tuvo su máximo brillo cuando era visible desde el hemisferio norte. Presentó la clásica cola de polvo curva, y con su aspecto casi estelar, destacándose entre la luminosidad del crepúsculo. Instrumentos Utilizados: Telezoom de 210mm a f/4.5, Telescopio refractor de 80mm a f/15, Binocular 10 x 50

Arquiola, A.


Deadly Lahars from Nevado del Ruiz, Colombia: November 13, 1985  

NSDL National Science Digital Library

This web site describes a series of Lahars that occurred from the Nevado del Ruiz volcano in the Andes mountains, the northernmost and highest volcano in Colombia. Beginning in November 1984, the volcano began showing clear signs of unrest. An explosive eruption from Ruiz's summit crater on November 13, 1985, at 9:08 p.m. generated an eruption column and sent a series of pyroclastic flows and surges across the volcano's summit. Within minutes, pumice and ash began to fall to the northeast along with heavy rain that had started earlier in the day. Within four hours, lahars had traveled 100 km and left behind a wake of destruction: more than 23,000 people killed, about 5,000 injured, and more than 5,000 homes destroyed along the Chinchina, Guali, and Lagunillas rivers and destroying the town of Armero, Columbia. This deadly eruption of Nevado del Ruiz offers lessons on the generation of lahars for scientists, emergency-response professionals, and communities located downstream of such ice- and snow-covered volcanoes. The narrative is illustrated with 9 photographs.

Banks, N.; Marso, J.; Pierson, T.; Janda, R.


Descubrimiento del primer yacimiento cuaternario (Riss-Wiirm) de vertebrados con restos humanos en la provincia de Madrid (Pinilla del Valle)  

Microsoft Academic Search

We give notice of a new fossiliferous loeality with vertebrate rests of Pleistocene age, placed in Pinilla del Valle (Madrid). It is made up by quaternary sediments filling a ca)careous fallen shelter.



Targeting F508del-CFTR to develop rational new therapies for cystic fibrosis  

Microsoft Academic Search

The mutation F508del is the commonest cause of the genetic disease cystic fibrosis (CF). CF disrupts the function of many organs in the body, most notably the lungs, by perturbing salt and water transport across epithelial surfaces. F508del causes harm in two principal ways. First, the mutation prevents delivery of the cystic fibrosis transmembrane conductance regulator (CFTR) to its correct

Zhi-wei Cai; Jia Liu; Hong-yu Li; David N Sheppard



Violación del Principio de Equivalencia en Teorías con Dilatón de Cuerdas  

Microsoft Academic Search

Se estudian las violaciones al Principio de Equivalencia en Teorías con Dilatón de Cuerdas. En estos modelos, algunas de las constantes fundamentales dependen del espacio y del tiempo. Se muestra que los experimentos de caída libre no tienen aún precisión como para poner límites a los parámetros de la teoría.

S. J. Landau; P. D. Sisterna; H. Vucetich



Violación del Principio de Equivalencia en Teorías con Dilatón de Cuerdas  

NASA Astrophysics Data System (ADS)

Se estudian las violaciones al Principio de Equivalencia en Teorías con Dilatón de Cuerdas. En estos modelos, algunas de las constantes fundamentales dependen del espacio y del tiempo. Se muestra que los experimentos de caída libre no tienen aún precisión como para poner límites a los parámetros de la teoría.

Landau, S. J.; Sisterna, P. D.; Vucetich, H.


El Instituto Nacional del Cáncer publica nuevo atlas de mortalidad por cáncer

El Instituto Nacional del Cáncer (NCI, por sus siglas en inglés) ha publicado un nuevo atlas, el Atlas de Mortalidad por Cáncer en los Estados Unidos, 1950-94, que muestra los patrones geográficos de las tasas de mortalidad por cáncer durante más de cuatro décadas, en más de 3.000 condados a lo largo del país.


Vertebrates of the El Pelillal locality (Campanian, Cerro Del Pueblo Formation), southeastern Coahuila, Mexico  

Microsoft Academic Search

A new locality named El Pelillal (Cerro del Pueblo Formation, Late Cretaceous, Campanian) in the southeastern area of the State of Coahuila, México yields an assemblage of vertebrates that is important for correlation due to its frequent occurrence in other localities along the Cerro del Pueblo Formation outcrops. It is located in the Municipio de Ramos Arizpe, Coahuila. Among the

Ruben A. Rodriguez-De La Rosa; Sergio R. S. Cevallos-Ferriz



Determinantes del precio de la vivienda en Santiago: Una estimación hedónica  

Microsoft Academic Search

Siguiendo la tradición de una extensa literatura de la economía urbana, desarrollada a partir de la base teórica propuesta por Rosen (1974), aquí se utiliza un modelo de precios hedónicos para analizar la determinación del precio de la vivienda (casas) en el mercado de Santiago. La estimación empírica del modelo permite explicar sobre el 70 por ciento de la varianza

Eugenio Figueroa; George Lever


Caracterización del mercado de energía elétrica para usuarios no regulados en Colombia  

Microsoft Academic Search

En este artículo se presenta un análisis sobre las características del mercado de energía para usuarios no regulados en Colombia, el cual puede ser considerado como un sub-mercado dentro del mercado global de energía eléctrica en Colombia. En este análisis se incluye un indicador de concentración de mercado (Herfindahl-Hirschman), así como los porcentajes de participación en cubrimiento de demanda y

Ana Cecilia Escudero; Sergio Botero Botero



Boletín No 11: Caracterización del Trabajo Independiente y su Afiliación a la Seguridad Social en Colombia  

Microsoft Academic Search

El tema central del presente Boletín es aparentemente un tema de coyuntura. En efecto, la afiliación del trabajador independiente al sistema de seguridad social integral está generando arduos debates, económicos y jurídicos, desde la implementación de la Planilla Integrada de Liquidación de Aportes –PILA- a mediados de este año. Sin embargo, el trabajo independiente en relación a la seguridad social

Stefano Farne; Jesus Perdomo; Carlos Andrés Vergara



Eleven new cases of del(9p) and features from 80 cases  

Microsoft Academic Search

We report 11 cases of del(9p) and review 69 previously published ones. Of the 80 cases, 39 have a del(9p) as the sole anomaly. The symptoms are typical and diagnosis should be suspected at birth. The sex ratio does not appear to be unbalanced. A cardiac murmur is often present but surgery is rarely necessary. Mean IQ is 48. The

J L Huret; C Leonard; B Forestier; M O Rethoré; J Lejeune




Microsoft Academic Search

El sector ovino-extensivo de la Meseta Central Santacruceña, extensa región ecológica del centro-Norte de la provincia de Santa Cruz (Patagonia Argentina), en las últimas décadas atraviesa una situación de crisis, evidenciada en el escaso porcentaje de parcelas que mantienen el uso del suelo tradicional. Las interpretaciones con respecto a las causas de la crisis no son muy numerosas, en la

Alberto Vazquez




Microsoft Academic Search

RESUMEN En el cultivo de chile, la incidencia de la enfermedad marchitez del chile causada por el hongo oomyceto Phytophthora capsici Leo., constituye a nivel nacional, uno de los principales problemas que afectan la productividad del cultivo. El presente estudio tuvo como objetivo: conocer la respuesta de 14 aislados de Phytophthora capsici a diferentes fungicidas. Los fungicidas utilizados fueron azoxystrobin,

Luis Pérez-Moreno; Luisa Josefina Durán-Ortiz; Rafael Ramírez-Malagón; Jesús Ricardo Sánchez-Pale; Víctor Olalde-Portugal


Descubrimiento del conocimiento en base de datos utilizando herramienta de software libre, caso: DAIS  

Microsoft Academic Search

El desempeño académico es un indicador que muestra el nivel de desempeño escolar de los estudiantes, en el presente artículo se describe los resultados del proceso de descubrimiento del conocimiento en bases de datos (KDD) para identificar las asignaturas que inciden en el rendimiento académico de los estudiantes de la División Académica de Informática y Sistemas de la Universidad Juárez

José Luís Gómez Ramos; Homero Alpuín Jiménez; Candelario Vicente Osorio; Mirtha Angelica; Taracena Martinez


Efecto de la modificación del perfil en el rendimiento de altavoces dinámicos de radiación directa  

Microsoft Academic Search

Uno de los parámetros más significativos de los altavoces es, probablemente, su rendimiento. Este puede definirse como la relación entre la potencia radiada y la potencia eléctrica consumida. Normalmente se\\u000aexpresa en % y puede ser determinado aplicado expresiones en las que figuran los valores de los componentes del circuito equivalente del altavoz. Un primer elemento necesario es la impedancia

Jesús Alba Fernández; Jaime Ramis Soriano



El desarrollo de la creatividad a través del proceso docente como problema social  

Microsoft Academic Search

El artículo tiene como propósito reflejar aspectos sobre el desarrollo de la creatividad en estudiantes de Educación Inicial del Programa Nacional de Formación de Educadores y Educadoras (PNFE). En tal sentido el Problema científico es ¿Cómo perfeccionar los modos de actuación en los estudiantes del PNFE? El Objetivo está dirigido a la Elaboración de una metodología para favorecer el desarrollo

Magaly Sarmiento Romero



62. R.L.T., photographer November 1, 1934 DEL NORTE COUNTY, SECTION ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

62. R.L.T., photographer November 1, 1934 DEL NORTE COUNTY, SECTION D, HIGHWAY 1. REDWOOD CLEARING ON EXISTING LINE, 1-DN-71-A #26, R.L.T. 11-1-34. Stamped office copy. - Redwood National & State Parks Roads, California coast from Crescent City to Trinidad, Crescent City, Del Norte County, CA


El cuento del cáncer de cérvix podría tener un final feliz

El cuento del cáncer de cérvix podría tener un final feliz Por el Instituto Nacional del Cáncer El cáncer de cérvix fue en un tiempo la causa principal de muerte por cáncer entre mujeres estadounidenses. Pero, en los últimos 50 años, el número de


Aspectos generales de la Red Nacional de Estudios Clínicos del NCI

Reseña general sobre la estructura organizativa de la Red Nacional de Estudios Clínicos del NCI, así como un resumen de los cambios que se están llevando a cabo y una sinopsis de cómo estos cambios se basan en el éxito del programa de Grupos Cooperativos.


63. G.F.H., photographer July 30, 1932 DEL NORTE COUNTY, SECTION ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

63. G.F.H., photographer July 30, 1932 DEL NORTE COUNTY, SECTION A, HIGHWAY 1. 1-DN A #124, STA. 164=00 SHOWING DRAINAGE CONDITIONS, G.F.H., 7-30-32. - Redwood National & State Parks Roads, California coast from Crescent City to Trinidad, Crescent City, Del Norte County, CA


Estudio del Selenio y la Vitamina E para Prevenir el Cáncer (SELECT)

SELECT sigue evaluando los efectos de los suplementos aunque los participantes ya no toman los suplementos del estudio. El Comité de Vigilancia de Datos y Seguridad del estudio, que opera con plena independencia, descubrió que el selenio y la vitamina E, tomados solos o juntos por un promedio de 5 años y medio, no impiden el cáncer de próstata.


Los grupos fricativa+nasal del polaco: realización sonora y fenómenos intermedios  

Microsoft Academic Search

El presente trabajo es un estudio de la sonoridad y de los fenómenos intermedios en la realización de los grupos consonanticos fricativa + nasal del polaco. El estudio acústico se ha realizado mediante el sistema CSL, en el que se pueden observar simultáneamente el oscilograma, el espectrograma, la onda glotal y los pulsos glotales. Los resultados del análisis han puesto

Dorota Szmidt; Joan Castellví Vives



Crueldad, simulacion, absurdo y amenaza: Barbarie del drama moderno y tradicion hermetica en los esperpentos de Ramon del Valle-Inclan  

Microsoft Academic Search

The purpose of this dissertation is to demonstrate that the esperpentos by the Spanish playwright Ramón del Valle-Inclán (1866–1936), represent a culminating moment of theatrical precepts of modern European drama, while perpetuating the ancient esoteric traditions of the Iberian Peninsula. Focusing on four plays—Los cuernos de Don Friolera (1920), Luces de Bohemia (1921), Las galas del difunto (1926) y La

Barbara Safille



Metodologie di diagnosi e monitoraggio della malattia dell'Occhio Secco: Rapporto del Sottocomitato Metodologia Diagnostica del Workshop Internazionale dell'Occhio Secco (2007) Metodologia Diagnostica  

Microsoft Academic Search

Il ruolo del Sottocomitato Metodologia Diagno- stica del Workshop dell'Occhio Secco è stato: 1) identificare i test utilizzati per lo screening, la diagnostica e il monito- raggio dell'occhio secco, 2) stabilire i criteri per l'esecuzione dei test e 3) valutare l'utilizzo dei test per i vari impieghi clini- ci. Il Comitato ha creato un database di test utilizzati per dia-

Membri del Sottocomitato; Metodologia Diagnostica; Antony J. Bron; Anthony J. Bron; Mark B. Abelson; George Ousler; E. Pearce; Alan Tomlinson; Norihiko Yokoi; Janine A. Smith; Carolyn Begley; Barbara Caffery; Kelly Nichols; Debra Schaumberg; Oliver Schein; Margarita Calonge; Christophe Baudouin; Eiki Goto; Franz Grus; Jerry Paugh


78 FR 6173 - Diana Del Grosso, Ray Smith, Joseph Hatch, Cheryl Hatch, Kathleen Kelley, Andrew Wilklund, and...  

Federal Register 2010, 2011, 2012, 2013

...Transportation Board [Docket No. FD 35652] Diana Del Grosso, Ray Smith, Joseph Hatch, Cheryl Hatch, Kathleen Kelley, Andrew Wilklund...petition filed on August 1, 2012, by Diana Del Grosso, Ray Smith, Joseph Hatch, Cheryl Hatch, Kathleen Kelley, Andrew...




Microsoft Academic Search

Resumen El objetivo del presente trabajo es presentar las relaciones existentes entre algunas de las actividades forestales actualmente desarrolladas en Forestal Bosques del Plata S.A. y el sistema de información geográfica (SIG) vigente. Con el uso de nuevas tecnologías y capacitación del personal se han desarrollado proyectos de estudios de plantación establecida, instalación de parcelas permanentes, fichas de rodal y

R. Trujillo; R. Pezzutti; S. Schmidt; F. Rodríguez


Infraestructuras urbanas de la Segunda Revolución Tecnológica. La difusión del teléfono en las ciudades españolas, 1877-1930  

Microsoft Academic Search

El uso del teléfono es en el mundo globalizado de hoy algo tan indisolublemente ligado a nuestros hábitos cotidianos que resulta casi impensable concebir una época en que tal servicio estuviera ausente. Profundizar en el estudio del origen y desarrollo del teléfono supone, pues, enfrentarse con algunas de las claves de la civilización actual. \\u000a\\u000aLa difusión del teléfono en las

Àngel Calvo Calvo



Disruption of cytokeratin-8 interaction with F508del-CFTR corrects its functional defect  

PubMed Central

We have previously reported an increased expression of cytokeratins 8/18 (K8/K18) in cells expressing the F508del mutation of cystic fibrosis transmembrane conductance regulator (CFTR). This is associated with increased colocalization of CFTR and K18 in the vicinity of the endoplasmic reticulum, although this is reversed by treating cells with curcumin, resulting in the rescue of F508del-CFTR. In the present work, we hypothesized that (i) the K8/K18 network may interact physically with CFTR, and that (ii) this interaction may modify CFTR function. CFTR was immunoprecipitated from HeLa cells transfected with either wild-type (WT) CFTR or F508del-CFTR. Precipitates were subjected to 2D-gel electrophoresis and differential spots identified by mass spectrometry. K8 and K18 were found significantly increased in F508del-CFTR precipitates. Using surface plasmon resonance, we demonstrate that K8, but not K18, binds directly and preferentially to the F508del over the WT human NBD1 (nucleotide-binding domain-1). In vivo K8 interaction with F508del-CFTR was confirmed by proximity ligation assay in HeLa cells and in primary cultures of human respiratory epithelial cells. Ablation of K8 expression by siRNA in F508del-expressing HeLa cells led to the recovery of CFTR-dependent iodide efflux. Moreover, F508del-expressing mice topically treated with K8-siRNA showed restored nasal potential difference, equivalent to that of WT mice. These results show that disruption of F508del-CFTR and K8 interaction leads to the correction of the F508del-CFTR processing defect, suggesting a novel potential therapeutic target in CF.

Colas, Julien; Faure, Grazyna; Saussereau, Emilie; Trudel, Stephanie; Rabeh, Wael M.; Bitam, Sara; Guerrera, Ida Chiara; Fritsch, Janine; Sermet-Gaudelus, Isabelle; Davezac, Noelie; Brouillard, Franck; Lukacs, Gergely L.; Herrmann, Harald; Ollero, Mario; Edelman, Aleksander



Assessing Glacier Hazards At Ghiacciaio Del Belvedere, Macugnaga, Italian Alps  

NASA Astrophysics Data System (ADS)

The uppermost section of the Valle Anzasca behind and above the community of Macugnaga in the Italian Alps is one of the most spectacular high-mountain land- scapes in Europe, with gigantic rock walls and numerous steep hanging glaciers. Its main glacier, Ghiacciaio del Belvedere at the foot of the huge Monte Rosa east face, is a heavily debris-covered glacier flowing on a thick sediment bed. Problems with floods, avalanches and debris flows from this ice body have been known for extended time periods. Most recently, however, the evolution of this highly dynamic environ- ment has become more dramatic. An outburst of Lago delle Locce, an ice-dammed lake at the confluenec of the tributary Ghiacciaio delle Locce with Ghiacciaio del Belvedere, caused heavy damage in 1979 and necessitated site investigation and con- struction work to be done for flood protection. The intermittent glacier growth ten- dency in the 1970es induced strong bulging of the glacier surface and, in places, caused the glacier tongue to override historical morains and to destroy newly-grown forest stands. A surge-type flow acceleration started in the lower parts of the Monte- Rosa east face during summer 2000, leading to strong crevassing and deformation of Ghiacciaio del Belvedere and extreme bulging of its orographic right margin. High water pressure and accelerated movement lasted into winter 2001/2002: the ice now started overriding the LIA moraine near Rifugio Zamboni of the CAI. In addition but rather independently, a most active detachment zone for rock falls and debris flows developed for several years now in the east face of Monte Rosa, somewhat more to the south of the accelerated glacier movement and at an altitude where relatively warm permafrost must be expected. Besides the scientific interest in these phenomena, the growing hazard potential to the local infrastructure must be considered seriously. Es- pecially potentials for the destabilization of large rock and ice masses in the east face of Monte Rosa, for interruption of the access trail to the Rifugio Zamboni by overrid- ing and/or collapse of the lateral moraine, for impacts by ice invading various instal- lations (cable car, restaurant, ski runs, trails) near the moraine hill of Belvedere, and for sudden outbursts of pressurized subglacial water or the newly formed supraglacial lake must be envisaged.

Haeberli, W.; Chiarle, M.; Mortara, G.; Mazza, A.


Evaluación y perspectivas del Código Nacional de Recursos Naturales de Colombia en sus 30 años de vigencia  

Microsoft Academic Search

Los artículos presentados estudian la eficacia, vigencia y perspectivas del Código Nacional de Recursos Naturales, decreto 2811 de 1974, teniendo de presente el avanzado estado de la ciencia en Colombia establecido por la Constitución del 91, y la Ley 99 de 1993; de esta manera los doctrinantes retoman la historia y las funciones del Código, la biodiversidad, la diversidad de

Autores varios


Taphonomy of guanaco bones in Tierra del Fuego  

NASA Astrophysics Data System (ADS)

Guanaco carcasses are deposited in great quantities in Cabo San Pablo, Tierra del Fuego (Argentina), as a result of winter stress. Taphonomic studies indicate that the gnawing action of foxes on guanaco ( Lama guanicoe) carcasses produces only very tenuous marks on the bones. Lack of sustained interest in the carcasses by carnivores results in slow disarticulation. The articulated and disarticulated bones are exposed to heavy trampling by guanacos, a process that produces vertical migration of small/dense bones and fracturing of the most weathered bones. An understanding of this ongoing process is important for local archaeology, since modern bones are migrating into archaeological contexts. A regional approach to taphonomy is the most appropriate instrument to solve this and other related problems.

Borrero, Luis Alberto



Clean cities: Award winning coalition -- Paso del Norte  

SciTech Connect

Designated the 41st Clean Cities coalition in November 1995, the Paso del Norte Clean Cities Coalition (PDNCCC) is the first in the country to gain international participation. Spanning the US-Mexico border; the coalition includes stakeholders from El Paso, Texas; Ciudad Juarez, Mexico; and Las Cruces, New Mexico. PDNCCC developed a comprehensive plan to jump-start its program place, alternative fuel vehicles (AFVs) on the road, and eliminate barriers inhibiting alternative fuel market growth. PDNCC raised more than $2.3 million for alternative fuel activities and clean air initiatives in less than 26 months. In 1998, the US Department of Energy (DOE) recognized that PDNCCC accomplishment with its Rainmaker Award for leveraging the most funds from outside sources. PDNCCC is proud of its efforts to drive the alternative fuels and AFV market in the El Paso/Juarez region.

O'Connor, K.



High precision ages from the Torres del Paine Intrusion, Chile  

NASA Astrophysics Data System (ADS)

The upper crustal bimodal Torres del Paine Intrusion, southern Chile, consists of the lower Paine-Mafic- Complex and the upper Paine-Granite. Geochronologically this bimodal complex is not well studied except for a few existing data from Halpern (1973) and Sanchez (2006). The aim of this study is to supplement the existing data and to constrain the age relations between the major magmatic pulses by applying high precision U-Pb dating on accessory zircons and 40Ar/39Ar-laser-step-heating-ages on biotites from the Torres del Paine Intrusion. The magmatic rocks from mafic complex are fine to medium-grained and vary in composition from quartz- monzonites to granodiorites and gabbros. Coarse-grained olivine gabbros have intruded these rocks in the west. The granitic body is represented by a peraluminous, biotite-orthoclase-granite and a more evolved leucocratic granite in the outer parts towards the host-rock. Field observations suggest a feeder-zone for the granite in the west and that the granite postdates the mafic complex. Two granite samples of the outermost margins in the Northeast and South were analyzed. The zircons were dated by precise isotope-dilution U-Pb techniques of chemically abraded single grains. The data are concordant within the analytical error and define weighted mean 206/238U ages of 12.59 ± 0.03 Ma and 12.58 ± 0.01 Ma for the two samples respectively. A 40Ar/39Ar-age for the second sample yield a date of 12.37 ± 0.11 Ma. Three 40Ar/39Ar -ages of biotites were obtained for rocks belonging to the mafic complex. A hbl-bio- granodiorite from the central part, approximately 150 m below the subhorizontal contact with the granite, gives an age of 12.81 ± 0.11 Ma. A hbl-bio-granodiorite and an olivine-gabbro west of the feeder-zone date at 12.42 ± 0.14 Ma and 12.49 ± 0.11 Ma, respectively. The obtained older age of 12.81 Ma for the granodiorite in the central part is consistent with structural relationships of brittle fracturing of the mafic complex by the granite and we conclude that some parts of the mafic complex were emplaced before the granite. The well defined 206/238U-age for zircons and the slightly younger 40Ar/39Ar -ages for biotites of both rock suites show that emplacement and cooling of the Torres del Paine Intrusion took place in a relatively short time-frame. Halpern, 1973, Geological Society of America Bulletin, 84/7: 2407-2422. Sanchez, 2006. V SSAGI, Punta del Este, April 2006.

Michel, J.; Baumgartner, L.; Cosca, M.; Ovtcharova, M.; Putlitz, B.; Schaltegger, U.



[Scorpions(Arachnida) from Bocas del Toro archipelago, Panamá].  


Four species of buthid scorpions (Ananteris platnicki Lourenço, 1993; Centruroides limbatus [Pocock, 1898]; Tityus pachyurus [Pocock, 1897]; and T. ocelote Francke and Stockwell, 1987) are recorded for the first time from some islands and cays of the Bocas del Toro Archipelago, Panama. Morphological variation and ecological data are given for all the species. This is the first Panamanian record for both C. limbatus and T. ocelote. The scorpion fauna of the Bocas de Toro Archipelago is related with the recent fauna of the Atlantic continental lowland region of Costa Rica and Panama and includes Amazonian-Guyanese (genera Ananteris and Tityus) as well as Mexican-North Central American (genus Centruroides) elements. PMID:12298241

Montoya, Michel; de Armas, Luis F



Numerical Kähler-Einstein Metric on the Third del Pezzo  

NASA Astrophysics Data System (ADS)

The third del Pezzo surface admits a unique Kähler-Einstein metric, which is not known in closed form. The manifold’s toric structure reduces the Einstein equation to a single Monge-Ampère equation in two real dimensions. We numerically solve this nonlinear PDE using three different algorithms, and describe the resulting metric. The first two algorithms involve simulation of Ricci flow, in complex and symplectic coordinates respectively. The third algorithm involves turning the PDE into an optimization problem on a certain space of metrics, which are symplectic analogues of the “algebraic” metrics used in numerical work on Calabi-Yau manifolds. Our algorithms should be applicable to general toric manifolds. Using our metric, we compute various geometric quantities of interest, including Laplacian eigenvalues and a harmonic (1,1)-form. The metric and (1,1)-form can be used to construct a Klebanov-Tseytlin-like supergravity solution.

Doran, Charles; Headrick, Matthew; Herzog, Christopher P.; Kantor, Joshua; Wiseman, Toby



Ozone studies in the Paso del Norte region  

NASA Astrophysics Data System (ADS)

The Paso del Norte region forms the largest contiguous bi-national conglomerate on the US-Mexico border. With a combined population of around 2 million inhabitants, the Paso del Norte region is isolated, more than 500 km away from the nearest urban area of comparable size, thus making it an ideal location for air quality studies of an isolated urban environment. The meteorological conditions leading to a high ozone episode in this region, such as the historical ozone episode of June 2006, are analyzed. It is well known that stagnation and minimal winds, high temperatures, and pressure ridges over the region are conducive to high ozone episodes. In addition, the planetary boundary height is studied to understand its impact on high ozone episodes. Several studies report that ground level ozone non-attainment regulations could be caused not only by local emissions, but also by atmospheric transport. In this work the atmospheric advection of pollutants into the region is analyzed using HYSPLIT backward trajectories. Furthermore, a novel backward trajectory clustering technique is implemented for the summer of 2006. The "ozone weekend effect" (OWE) is a phenomenon by which in some geographical regions ambient ozone concentrations tend to be higher on weekends than on weekdays, despite the lower emissions of ozone precursors during those days. The observed local OWE has never previously been studied in terms of the photolysis rates of four of the main ozone precursors. In this research a novel method that allows the calculation of actinic fluxes, photolysis frequencies and photolysis rates with a high degree of accuracy and reliability has been developed. This method utilizes a combination of the experimental data available for this region in conjunction with a radiative transfer model (TUV model). Three weekend-weekday cases during summers 2006, 2009 and 2010 are studied in this work. In this research, the photolysis impact on the local OWE is studied. The results obtained from this photolysis study demonstrate that the local ground level ozone formation is not only influenced by the strong solar radiation and changing aerosol makeup, but also by other heterogeneous factors and reactions. In addition, this research provided good evidence that the ground level ozone precursor regime in El Paso during the ozone episode of June 2006 was mostly VOC-limited. Much of this estimation was derived from measurements of local ambient VOC/NOx ratios. This finding shows that at least during June 2006, the non-linear surface ozone production increased during weekends compared to workdays in a habitually VOC-limited regime. The seasonal variations of columnar ozone as measured by a Multi-filter Rotating Shadowband instrument installed at the UTEP campus are analyzed for the first time for this region and results are presented. This investigation has addressed the problem of ground-level ozone formation in the Paso del Norte region. Urban ozone is a complex problem with many aspects that are not fully understood. In this investigation, a range of techniques has been used to address the study of local surface ozone episodes with the purpose of acquiring new insights and knowledge that will help understand and remediate the diverse atmospheric pollution events that affect this bi-national region recurrently. Innovative techniques were developed and used, ranging from the use of local ambient atmospheric pollution data to the utilization of complex modeling techniques to achieve the best possible computer results. Finally, the influence of ground level ozone concentrations in admissions to hospitals for this region due to respiratory diseases is analyzed. The comprehensive results obtained in this work will help to better understand ozone formation in the Paso del Norte Region for future policy regulation implementations.

Becerra-Davila, Fernando


Nutritional and functional properties of aqueous and hydroalcoholic extracts from Argentinean propolis.  


Bee propolis is a natural product extensively used as an ingredient in functional foods in amounts that may confer health benefits. The aim of this study was to investigate the nutritional and functional properties (antioxidant activity) of aqueous and ethanolic extracts of propolis samples from Santiago del Estero province, northern Argentina. All propolis extracts contained macronutrients (glucose, fructose, sucrose and proteins), micronutrients (Na, K, Ca, P and Mg) and trace elements (Fe). Spectrophotometric, TLC and HPLC-DAD analyses showed the presence of several phenolic, flavonoid and non-flavonoid compounds, but in all cases the flavonoids prevailed. The PCA of polyphenolic content provided a clear separation of propolis in Group 1 (SE1, 2, 3, 4 and 7) and Group 2 (SE5 and 6) associated with phenolic compound content and collection regions. Two compounds, pinocembrin and chrysin, which could be used as chemical markers of Santiago del Estero propolis, were identified in all samples. Propolis samples extracted with water presented better radical scavenging ability than ethanolic extracts, independent of the antioxidant method (scavenging activity of ABTS*+, DPPH*, HO* and O2(-)* and beta-carotene bleaching test). Such results correlated closely with the levels of total phenols and flavonoids in samples. The results justify the use of Argentine propolis as a functional dietary supplement. PMID:24689282

Danert, Fátima C; Zampini, Catiana; Ordoñez, Roxana; Maldonado, Luis; Bedascarrasbure, Enrique; Isla, María Inés



Isotope hydrology of groundwaters in the Pampa del Tamarugal, Chile  

NASA Astrophysics Data System (ADS)

The water resources in northern Chile are extremely scarce and development is limited by this. This paper discusses the isotope hydrology of groundwaters in the Pampa del Tamarugal — an area of extreme aridity (rainfall < 1 mm/yr.) — whose groundwater resources are mined for the town of Iquique, as well as for industrial and agricultural purposes. The aim of the project was to obtain information on modern recharge and to delineate, if possible recharge environments. To obtain the necessary background information a precipitation survey in the high Andes, as well as spring- and surface-water studies were carried out. The results show that a well-defined meteoric water line exists where ? 2H = (7.8 ? 18O + 10.3)% , and altitude effects depend on air-mass movements and cannot be defined without a broader regional and detailed sampling programme. However, it is still possible to assign maximum altitudes of recharge to springs in the Andes and at the eastern border of the Pampa del Tamarugal. Comparison of these data with groundwater compositions show, that these groundwaters originate from infiltrating surface water rather than directly infiltrated precipitation. A dependence of individual groundwater systems on specific quebradas (river valleys) is recognized. However, low 14C activities indicate that most of the waters pumped today are fossil and at least several hundreds if not thousands of years old. Some minor subsurface recharge does occur at the foot of the Andes, especially at Pica where high-altitude waters discharge, but even there groundwater appears to be a diminishing resource.

Fritz, P.; Suzuki, O.; Silva, C.; Salati, E.



El camino recorrido: el aporte del Grupo Banco Interamericano de Desarrollo (BID) a la microempresa en los últimos 30 años en El Salvador  

Microsoft Academic Search

La idea de este libro surge con motivo del décimo aniversario de la celebración del Foro Interamericano de la Microempresa, esta vez con sede en El Salvador. El objetivo del mismo es contribuir a documentar el impacto producido por iniciativas del banco durante estos treinta años de trabajo conjunto con la microempresa en El Salvador. El libro presenta un resumen

Mercedes del Carmen Góchez; Carmen Cristina Álvarez



Modelli history-friendly dell'evoluzione delle industrie: il caso dell'industria del computer  

Microsoft Academic Search

Modelli history-friendly dell'evoluzione delle industrie: il caso dell'industria del computer (di Franco Malerba, Luigi Orsenigo) - ABSTRACT: In this paper, we review and discuss the main features of a new generation of evolutionary models: \\

Luigi Orsenigo; Franco Malerba



Geostatistical investigations of rock masses. The Sierra del Medio Case (Argentina).  

National Technical Information Service (NTIS)

The geostatistical tehniques applied for the selection of a minimun fracturation volume in Sierra del Medio allow to quantify and qualify the variability of mechanic characteristics and density of fracture and also the level of reliability in estimations....

J. A. Matar M. A. Sarquis J. P. Girardi G. H. Tabbia



[Progress in InDel as a new generation of genetic marker].  


As forensic DNA typing experienced three generations of genetic marker researching stage, short tandem repeat (STR) has been widely used in forensic identification as a mature tool. Further exploration of the human genome led to the discovery of polymorphism markers of single nucleotide polymorphism (SNP) and Insertion/Deletion (InDel). InDel, which combines the desirable characteristics of previous genetic markers as a new type of genetic marker, has got extensive concern in fields like medical molecular biology and forensic biology. This paper generally reviews the history of research and the corresponding results of InDel along the line of time axis as well as the different aims of these research focusing on the progress in the multiple amplification system with several InDel as the genetic marker (autosomal or X chromosome) in forensic biology and anthropology. Finally, the direction of research in this field and the problems to be solved have been put forward. PMID:23930511

Sun, Kuan; Zhang, Su-Hua; Zhu, Ru-Xin; Zhao, Shu-Min; Li, Cheng-Tao



The extracellular matrix protein Del1 induces apoptosis via its epidermal growth factor motif.  


Mouse Del1 is an extracellular matrix protein mainly expressed in the developing embryo. Del1 has three EGF motifs and two discoidin domains. The second EGF motif reportedly contains an RGD sequence that binds to integrin receptors. Here, we provide evidence that Del1 protein induces cell death in vitro. Chromatin condensation and DNA laddering were observed, suggestive of apoptosis. The results of analysis using the TUNEL method and annexin V staining were also consistent with apoptosis. The apoptosis-inducing activity of Del1 could be mapped to the third EGF motif, which fitted the consensus sequence CX(D/N)XXXX(F/Y)XCXC, wherein the aspartic acid residue (D) could be beta-hydroxylated. As little as twenty-five picomolar of recombinant E3 could induce apoptosis. PMID:20171188

Kitano, Hisataka; Kokubun, Shinichiro; Hidai, Chiaki



EFECTO DEL GATUÑO SOBRE LA FERTILIDAD DEL SUELO Y LA BIOMASA HERBÁCEA EN PASTIZALES DEL CENTRO DE MÉXICO Effect of Catclaw Mimosa on Soil Fertility and Forage Yield in Rangelands in Central Mexico  

Microsoft Academic Search

RESUMEN El trabajo se realizó durante los años 2002 y 2003, en los estados de Aguascalientes y Jalisco, con el objetivo de evaluar el efecto del gatuño (Mimosa monancistra) en el grado de asociación de algunas variables edáficas, como pH, materia orgánica (MO), fósforo, calcio y magnesio, así como la cantidad de biomasa herbácea en tres sitios con diferente grado

Ernesto Flores; Juan Frías; Pedro Jurado; Víctor Olalde; Juan de Dios Figueroa; Arturo Valdivia; Edmundo García



Microsoft Academic Search

RESUMEN. En este trabajo se presenta una revisión de los cambios que se han producido en los últimos años en las ecuaciones de estado cúbicas de más amplia aceptación y se hace un estudio comparativo del cálculo del volumen específico de once líquidos puros por medio de cinco ecuaciones cúbicas: Van der Waals, Redlich-Kwong, Soave-Redlich-Kwong, Peng-Robinson y Valderrama-Patel- Teja .



Calculo del valor de la cuota lactea en las explotaciones de leche gallegas  

Microsoft Academic Search

RESUMEN: El nivel de cuota l�ctea por explotaci�n y la transferencia de cuota entre las distintas explotaciones juegan un papel principal en la reestructuraci�n del sector productor de leche en Espa�a. En este trabajo se estiman el valor de una unidad de cuota, de su valor de capitalizaci�n en el horizonte del a�o 2006 y la concreci�n de algunos determinantes

Jose Carlos De Miguel Dominguez; Tomas Perez Vidal; Xose Anton Rodriguez Gonzalez



Avaluació de plantes protegides, amenaçades o rares al Parc Natural del Cadí-Moixeró (Pirineus orientals)  

Microsoft Academic Search

Sintetitzem els resultats obtinguts des de 1995 amb l'estudi de les plantes rares o protegides del Parc Natural del Cadí-Moixeró (Pirineus orientals, Catalunya). Es presenta una llista de flora d'interès especial d'aquest espai protegit, que actualment consta de 63 tàxons, distribuïts en 4 grups de diferent prioritat de conservació. Es donen dades sobre alguns tàxons per als quals s'han realitzat

Pere Aymerich i Boixader



El Teatre Principal de Figueres: una història del dinou (1814-1902)  

Microsoft Academic Search

Aquest article és una aproximació a la idea, el projecte i l’execució de l’equipament\\u000apúblic més rellevant que Figueres duu del segle XIX i part del XX, juntament amb la Rambla. El significat d’aquesta construcció, excessiva per a una ciutat petita, va molt més enllà de l’edifici neoclàssic, ja que suposa una nova manera d’entendre l’urbanisme públic de la mà

Alfons Martínez i Puig



[Molecular mechanism of RhDel phenotype in blood donation population of Chinese Harbin area].  


This study was aimed to explore the molecular mechanism of RhDel phenotype expression in blood donors of Chinese Harbin area. Three hundred and seventy-four RhD negative donors confirmed by indirect antiglobulin test were detected by using serological and molecular methods for red blood cell RhD blood group genotyping and RH gene variant detection. And the other special samples of undetermined RhD genotype were sequenced. The results showed that 62 cases of Del type were detected in 374 negative blood donors' samples, accounting for 16.6%, among them there were 61 cases of RHD1227A, and 1 case of rare RHD Del (cde) 1 allele was found. Sequencing analysis indicated that RHD711DelC allele existed in 11 cases. In addition, the new mutant alleles were found in 3 samples. It is concluded that RHD1227A allele is generally carried allele in Del phenotype population of Chinese Harbin area and is an important genetic marker in Del phenotype individual. PMID:23257457

Li, Ji-Hong; Zhang, Chun-Yan; Sun, Jian-Hua; Liu, Jie



Heterotic horizons, Monge-Ampère equation and del Pezzo surfaces  

NASA Astrophysics Data System (ADS)

Heterotic horizons preserving 4 supersymmetries have sections which are T 2 fibrations over 6-dimensional conformally balanced Hermitian manifolds. We give new examples of horizons with sections S 3 × S 3 × T 2 and SU(3). We then examine the heterotic horizons which are T 4 fibrations over a Kähler 4-dimensional manifold. We prove that the solutions depend on 6 functions which are determined by a non-linear differential system of 6 equations that include the Monge-Ampére equation. We show that this system has an explicit solution for the Kähler manifold S 2 × S 2. We also demonstrate that there is an associated cohomological system which has solutions on del Pezzo surfaces. We raise the question of whether for every solution of the cohomological problem there is a solution of the differential system, and so a new heterotic horizon. The horizon sections have topologies which include (( k - 1) S 2 × S 4# k( S 3 × S 3) × T 2 indicating the existence of exotic black holes. We also find an example of a horizon section which gives rise to two different near horizon geometries.

Gutowski, J.; Papadopoulos, G.



CASP8 -652 6N Del Polymorphism Contributes to Colorectal Cancer Susceptibility: Evidence from a Meta-Analysis  

PubMed Central

Objective Caspase-8 (CASP8) plays a central role in the apoptotic pathway and aberrant regulation of this pathway may cause cancers. Previous studies investigating the association between CASP8 -652 6N ins/del polymorphism and colorectal cancer (CRC) risk showed inconclusive results. We performed a meta-analysis of all available studies to investigate this association. Methods All studies published up to October 2013 on the association between CASP8 -652 6N ins/del polymorphism and CRC risk were identified by searching electronic databases PubMed, EMBASE, and Cochrane library. The association between CASP8 -652 6N ins/del polymorphism and CRC risk was assessed by odds ratios (ORs) together with their 95% confidence intervals (CIs). Results Six studies with 6,325 cases and 6,842 controls were included in the meta-analysis. We observed that the CASP8 -652 6N ins/del polymorphism was significantly correlated with CRC risk when all studies were pooled into the meta-analysis (ins/del vs. ins/ins: OR?=?0.890, 95%CI 0.821–0.964, P?=?0.004; del/del + ins/del vs. ins/ins: OR?=?0.899, 95%CI 0.833–0.970, P?=?0.006). In stratified analyses by ethnicity, source of control, and quality score, significant association was observed in Asians (ins/del vs. ins/ins: OR?=?0.862, 95%CI 0.761–0.977, P?=?0.020; del/del + ins/del vs. ins/ins: OR?=?0.845, 95%CI 0.749–0.953, P?=?0.006), population-based studies (ins/del vs. ins/ins: OR?=?0.890, 95%CI 0.813–0.975, P?=?0.012; del/del + ins/del vs. ins/ins: OR?=?0.901, 95%CI 0.827–0.982, P?=?0.018), and high quality studies. However, in subgroup analysis according to cancer location, no significant association was detected. Conclusions The present meta-analysis suggests that the CASP8 is a candidate gene for CRC susceptibility. The CASP8 -652 6N ins/del polymorphism may play a protective role in CRC development especially among Asians. Further large and well-designed studies are needed to confirm this association.

Chen, Zhiping; Li, Ruolin; Wang, Jian; Deng, Yan; Li, Taijie; Qin, Xue; Li, Shan



Resolución de problemas basada en el análisis. Hacer del análisis y del razonamiento el foco de la enseñanza de la física  

Microsoft Academic Search

Resumen. Usando los resultados provenientes de la investigación educativa en áreas tales como concepciones alternativas, diferencias entre expertos y novatos, adquisición de esquemas, sobrecarga cognitiva y análisis jerárquico, hemos desarrollado un marco para pensar sobre la organización del conocimiento y su uso para la comunicación, y sobre el razonamiento y la resolución de problemas. Basados en este marco y en

J. Leonard William; William J. Gerace; Robert J. Dufresne




Microsoft Academic Search

A study of management of costal areas in the western gulf of Batabanó, southern coast of Pinar del Río province, is presented in three parts: environmental factors, socio economical factors and integrated management. Main characteristics of natural factors are analyzed, such as river supply of water to the coast, water temperature, salinity, dissolved oxygen, turbidity, ph, nutrients and organic nitrogen

Roberto Piñeiro; Rafael Puga; Gaspar González-Sansón


La red exterior de Puertos del Estado: Información oceanográfica en tiempo real. Puertos del Estado deep water network: Oceanographic information in real time  

Microsoft Academic Search

SUMMARY In the last 20 years, Puertos del Estado has settled a complex marine monitoring system that allows the access to real time oceanographic and meteorological information. One of the networks in this system is the deep water network with buoys deployed at open sea. The access to this information is completely free through the web pages where users can

Marta Alfonso; José Damián López; Isabel Ruiz; Enrique Álvarez; Nuevas Tecnologías



Microsoft Academic Search

This paper intends to assess the current situation of the application process of academic loans in higher education institutions and to visualize new decision-making scenarios to generate spaces, dynamics and methodologies needed for its appropriate implementation. The study was based on three national universities: Universidad Militar Nueva Granada in Bogotá, Corporación Universita- ria del Meta -Unimeta-, and Universidad de los




Screening for F508del as a first step in the molecular diagnosis of cystic fibrosis*,**  

PubMed Central

OBJECTIVE: To determine the relevance of screening for the F508del mutation of the cystic fibrosis transmembrane conductance regulator gene as a first step in the genetic diagnosis of cystic fibrosis (CF) by associating the genotype with various clinical variables. METHODS: We evaluated 180 CF patients regarding the F508del mutation. The clinical data were obtained from the medical records of the patients and from interviews with their parents or legal guardians. RESULTS: Of the 180 patients studied, 65 (36.1%) did not carry the F508del mutation (group 0 [G0]), 67 (37.2%) were F508del heterozygous (G1), and 48 (26.7%) were F508del homozygous (G2). All three groups showed associations with the clinical variables. Homozygosis was associated with younger patients, younger age at CF diagnosis, and younger age at the first isolation of Pseudomonas aeruginosa (PA), as well as with higher prevalence of pancreatic insufficiency (PI) and non-mucoid PA (NMPA) colonization. In comparison with G1+G2 patients, G0 patients were older; first experienced clinical symptoms, digestive disease, and pulmonary disease at an older age; were older at CF diagnosis and at first PA isolation; and had a lower prevalence of PI and meconium ileus, as well as of colonization by NMPA, mucoid PA, and Burkholderia cepacia. In G1 patients, values were intermediate for age at CF diagnosis; age at first PA isolation, first pulmonary symptoms, and first clinical manifestations; MPA colonization; and OR for PI. CONCLUSIONS: The identification of F508del in 63.9% of the patients studied showed that this can be a useful tool as a first step in the genetic diagnosis of CF. The F508del genotype was associated with clinical severity of the disease, especially with the variables related to CF onset.

Marson, Fernando Augusto de Lima; Bertuzzo, Carmen Silvia; Ribeiro, Maria Angela Goncalves de Oliveira; Ribeiro, Antonio Fernando; Ribeiro, Jose Dirceu



El comerç de pintura antiga i el col·leccionisme a Barcelona a la segona meitat del segle XIX  

Microsoft Academic Search

En aquesta presentació es fa un breu recorregut per les col·leccions pictòriques construïdes a Catalunya durant la primera meitat del segle XIX. Es citen, però, els dos precedents més destacats. El més antic és la col·lecció del músic moianès Josep Elies (1690-1779) que fou organista del convent de les Descalzas Reales de Madrid, ciutat en la qual aplegà pintura barroca

Bonaventura Bassegoda



Using Del-1 to tip the angiogenic balance in endothelial cells in modular constructs.  


Modular tissue engineering is a method of building vascularized tissue-engineered constructs. Submillimeter-sized collagen pieces (modules) coated with a layer of endothelial cells (EC; vascular component), and with embedded functional cells, are self-assembled into a larger, three-dimensional tissue. In this study, we examined the use of developmental endothelial locus-1 (Del-1), an extracellular matrix protein with proangiogenic properties, as a means of tipping the angiogenic balance in human umbilical vein endothelial cells incorporated in modular tissue-engineered constructs. The motivation was to enhance the vascularization of these constructs upon transplantation in vivo, in this case, without the use of exogenous mesenchymal stromal cells. EC were transduced using a lentiviral construct to overexpress Del-1. The Del-1 EC formed more sprouts in a fibrin gel sprouting assay in vitro compared with eGFP (control) transduced EC, as expected. Del-1 EC had a distinct profile of gene expression (upregulation of matrix metalloproteinase-9 [MMP-9], urokinase-type plasminogen activator [uPA/PLAU], vascular endothelial growth factor [VEGF-A], and intercellular adhesion molecule-1 [ICAM-1]; downregulation of angiopoietin-2 [Ang2]), also supporting the notion of "tipping the angiogenic balance". On the other hand, contrary to our expectations, when Del-1 EC-coated modules were implanted subcutaneously in a severe combined immunodeficient/beige animal model, the proangiogenic effect of Del-1 was less remarkable. There was only a small increase in the number of blood vessels formed in Del-1 implants compared with the eGFP implants, and only few blood vessels formed at the implant site in both cases. This was presumed due to limited EC survival after transplantation. We speculate that if we could improve EC survival in our study (for example, by adding other prosurvival factors or supporting cells), we would see a greater Del-1-induced angiogenic benefit in vivo as a consequence of increased Del-1 secretion by a higher number of surviving cells. PMID:24138448

Ciucurel, Ema C; Vlahos, Alexander E; Sefton, Michael V



Magnetic fabric of the Torres del Paine, Patagonia  

NASA Astrophysics Data System (ADS)

The Miocene bimodal Torres del Paine Intrusive Complex (TIPC) consists of the lower Paine-Mafic-Complex (PMC) and the overlaying Paine Granite. Igneous structures (layering, xenolith orientations, and major contacts) are vertical in the westernmost part of the PMC, while they are sub-horizontal in the central and eastern parts. The TPIC is very homogeneous except in the PMC where complex interactions between mafic and felsic magmas were observed. No foliation or lineations are present in the field. Based on field-observations we distinguish at least three different sheet-like units in the Paine Granite, each one several tens to hundreds of meters thick. Younger sheets generally under-plate their precursor. We measured the anisotropy of magnetic susceptibility (AMS) on 145 samples from sites distributed horizontally over the entire surface of the TPIC and along 4 vertical profiles. The high intensity of the magnetic susceptibility for most of the Paine Granite and the PMC samples is due to the presence of magnetite. The magnetic lineations show a general WNW-ESE trend, parallel to the long axis of the intrusion. Lineations in the western part are strongly west-dipping to subvertical, parallel to the magmatic layering in the PMC. This supports the interpretation of a feeder-zone in that area. The lineations are sub-horizontal in the rest of the intrusion. Only minor variations in lineation orientation are observed in several hundred meter long vertical profiles in the central part of the Paine Granite. The magnetic foliations show the structural control exerted by the contact of the intrusion during its assembly: they are mostly horizontal in the central part, and are progressively steeper towards the contact. The low anisotropy is in agreement with the absence of texture observed in the field and thin sections. No sub-solidus deformation took place during the TPIC construction. The internal structures and magnetic fabrics support the interpretation of an intrusion assembled by horizontal transfer of magma in the form of sheet-like pulses stacking them vertically. Our results also show that the regional syn-magmatic deformation played no role in the emplacement of the TPIC.

Michel, J.; Baumgartner, L.; de Saint-Blanquat, M.; Putlitz, B.; Sanchez, A.; Darbellay, B.; Cavargna, M.



The 1985 Nevado del Ruiz volcano catastrophe: anatomy and retrospection  

NASA Astrophysics Data System (ADS)

This paper seeks to analyze in an objective way the circumstances and events that contributed to the 1985 Nevado del Ruiz catastrophe, in order to provide useful guidelines for future emergencies. The paper is organized into two principal parts. In the first part, an Anatomy of the catastrophe is developed as a step-by-step chronicle of events and actions taken by individuals and organizations during the period November 1984 through November 1985. This chronicle provides the essential background for the crucial events of November 13. This year-long period is broken down further to emphasize essential chapters: the gradual awareness of the awakening of the volcano; a long period of institutional skepticism reflecting an absence of credibility; the closure of the credibility gap with the September 11 phreatic eruption, followed by an intensive effort to gird for the worst; and a detailed account of the day of reckoning. The second part of the paper, Retrospection, examines the numerous complicated factors that influenced the catastrophic outcome, and attempts to cull a few "lessons from Armero" in order to avoid similar occurrences in the future. In a nutshell, the government on the whole acted responsibly but was not willing to bear the economic or political costs of early evacuation or a false alarm. Science accurately foresaw the hazards but was insufficiently precise to render reliable warning of the crucial event at the last possible minute. Catastrophe was therefore a calculated risk, and this combination — the limitations of predication/detection, the refusal to bear a false alarm and the lack of will to act on the uncertain information available — provided its immediate and most obvious causes. But because the crucial event occurred just two days before the Armero emergency-management plan was to be critically examined and improved, the numerous circumstances which delayed progress of emergency management over the previous year also may be said to have contributed to the outcome. Thus the catastrophe was not caused by technological ineffectiveness or detectiveness, nor by an overwhelming eruption, or by an improbable run of bad luck, but rather by cumulative human error — by misjudgment, indecision and bureaucratic shortsightedness. Armero could have produces no victims, and therein dwells its immense tragedy.

Voight, Barry



The 1985 Nevado del Ruiz volcano catastrophe: anatomy and retrospection  

NASA Astrophysics Data System (ADS)

This paper seeks to analyze in an objective way the circumstances and events that contributed to the 1985 Nevado del Ruiz catastrophe, in order to provide useful guidelines for future emergencies. The paper is organized into two principal parts. In the first part, an Anatomy of the catastrophe is developed as a step-by-step chronicle of events and actions taken by individuals and organizations during the period November 1984 through November 1985. This chronicle provides the essential background for the crucial events of November 13. This year-long period is broken down further to emphasize important chapters: the gradual awareness of the awakening of the volcano; a long period of institutional skepticism reflecting an absence of credibility; the closure of the credibility gap with the September 11 phreatic eruption, followed by an intensive effort to gird for the worst; and a detailed account of the day of reckoning. The second part of the paper, Retrospection, examines the numerous complicated factors that influenced the catastrophic outcome, and attempts to cull a few "lessons from Armero" in order to avoid similar occurrences in the future. In a nutshell, the government on the whole acted responsibly but was not willing to bear the economic or political costs of early evacuation or a false alarm. Science accurately foresaw the hazards but was insufficiently precise to render reliable warning of the crucial event at the last possible minute. Catastrophe was therefore a calculated risk, and this combination - the limitations of prediction/detection, the refusal to bear a false alarm and the lack of will to act on the uncertain information available - provided its immediate and most obvious causes. But because the crucial event occurred just two days before the Armero emergency management plan was to be critically examined and improved, the numerous circumstances which delayed progress of emergency management over the previous year also may be said to have contributed to the outcome. Thus the catastrophe was not caused by technological ineffectiveness or defectiveness, nor by an overwhelming eruption, or by an improbable run of bad luck, but rather by cumulative human error - by misjudgment, indecision and bureaucratic shortsightedness. Armero could have produced no victims, and therein dwells its immense tragedy.

Voight, Barry



Correlated Occurrence and Bypass of Frame-Shifting Insertion-Deletions (InDels) to Give Functional Proteins  

PubMed Central

Short insertions and deletions (InDels) comprise an important part of the natural mutational repertoire. InDels are, however, highly deleterious, primarily because two-thirds result in frame-shifts. Bypass through slippage over homonucleotide repeats by transcriptional and/or translational infidelity is known to occur sporadically. However, the overall frequency of bypass and its relation to sequence composition remain unclear. Intriguingly, the occurrence of InDels and the bypass of frame-shifts are mechanistically related - occurring through slippage over repeats by DNA or RNA polymerases, or by the ribosome, respectively. Here, we show that the frequency of frame-shifting InDels, and the frequency by which they are bypassed to give full-length, functional proteins, are indeed highly correlated. Using a laboratory genetic drift, we have exhaustively mapped all InDels that occurred within a single gene. We thus compared the naive InDel repertoire that results from DNA polymerase slippage to the frame-shifting InDels tolerated following selection to maintain protein function. We found that InDels repeatedly occurred, and were bypassed, within homonucleotide repeats of 3–8 bases. The longer the repeat, the higher was the frequency of InDels formation, and the more frequent was their bypass. Besides an expected 8A repeat, other types of repeats, including short ones, and G and C repeats, were bypassed. Although obtained in vitro, our results indicate a direct link between the genetic occurrence of InDels and their phenotypic rescue, thus suggesting a potential role for frame-shifting InDels as bridging evolutionary intermediates.

Rockah-Shmuel, Liat; Toth-Petroczy, Agnes; Sela, Asaf; Wurtzel, Omri; Sorek, Rotem; Tawfik, Dan S.



Correlated occurrence and bypass of frame-shifting insertion-deletions (InDels) to give functional proteins.  


Short insertions and deletions (InDels) comprise an important part of the natural mutational repertoire. InDels are, however, highly deleterious, primarily because two-thirds result in frame-shifts. Bypass through slippage over homonucleotide repeats by transcriptional and/or translational infidelity is known to occur sporadically. However, the overall frequency of bypass and its relation to sequence composition remain unclear. Intriguingly, the occurrence of InDels and the bypass of frame-shifts are mechanistically related - occurring through slippage over repeats by DNA or RNA polymerases, or by the ribosome, respectively. Here, we show that the frequency of frame-shifting InDels, and the frequency by which they are bypassed to give full-length, functional proteins, are indeed highly correlated. Using a laboratory genetic drift, we have exhaustively mapped all InDels that occurred within a single gene. We thus compared the naive InDel repertoire that results from DNA polymerase slippage to the frame-shifting InDels tolerated following selection to maintain protein function. We found that InDels repeatedly occurred, and were bypassed, within homonucleotide repeats of 3-8 bases. The longer the repeat, the higher was the frequency of InDels formation, and the more frequent was their bypass. Besides an expected 8A repeat, other types of repeats, including short ones, and G and C repeats, were bypassed. Although obtained in vitro, our results indicate a direct link between the genetic occurrence of InDels and their phenotypic rescue, thus suggesting a potential role for frame-shifting InDels as bridging evolutionary intermediates. PMID:24204297

Rockah-Shmuel, Liat; Tóth-Petróczy, Ágnes; Sela, Asaf; Wurtzel, Omri; Sorek, Rotem; Tawfik, Dan S



Observaciones del disco solar y de una protuberancia quiescente en radiación ultravioleta  

NASA Astrophysics Data System (ADS)

Observaciones del disco solar y de una protuberancia quiescente en el rango de longitudes de onda ultravioleta fueron obtenidas con el instrumento CDS (Coronal Diagnostic Spectrograph) y SUMER (Solar Ultraviolet Measurements of emitted radiation) a bordo de la sonda SOHO. El propósito es investigar las velocidades macroscópicas de varias especies metálicas que se observan tanto en el disco solar como en el plasma de las protuberancias. Para calcular las velocidades del disco solar aplicamos una técnica mixta para modelar la distribución de estructuras en UV en el Sol quieto. Las velocidades macroscópicas en las protuberancias se calcularon a partir de los corrimientos Doppler en cada línea espectral y luego se tomaron las del disco solar como referencia. Obtuvimos valores absolutos para las velocidades macroscópicas entre 5 y 40 km/seg. También detectamos comportamientos diferentes en las velocidades de las protuberancias en el centro con respecto a los bordes.

Cirigliano, D.; Vial, J.-C.; Rovira, M.


CASE REPORT: Phenotypic presentation of the Ser63Del MPZ mutation  

PubMed Central

Mutations in MPZ cause CMT1B, the second most frequent cause of CMT1. Elegant studies with Ser63del mice suggest that Ser63del MPZ is retained in the ER where it activates the unfolded protein response (UPR) that contributes to the neuropathy. Clinical information about patients with this mutation is limited. We present clinical and electrophysiological data on a large multigenerational family with CMT1B caused by Ser63del MPZ. The patients have a classical CMT1 phenotype that is much less severe than that of patients with Arg98Cys MPZ that also activates the UPR. These results suggest that clinical presentation along cannot predict which MPZ mutations will be retained in the ER and activate the UPR.

Miller, Lindsey J.; Patzko, Agnes; Lewis, Richard A.; Shy, Michael E.



Biotic association and palaeoenvironmental reconstruction of the "Loma del Pterodaustro" fossil site (Early Cretaceous, Argentina)  

USGS Publications Warehouse

A sedimentological analysis of the basal section of the Early Cretaceous, lacustrine Lagarcito Formation at "Loma del Pterodaustro" (San Luis, Argentina) and a summary of its biological components are presented. Three sedimentological facies can be recognized in the basal sequence of the Lagarcito Formation. Fossil remains are particularly abundant in laminated claystones of a facies interpreted as deposits formed in offshore areas of the lake. The preservation of delicate structures allows recognition of these deposits as a Konservat Lagersta??tte. Up to now, rocks at "Loma del Pterodaustro" have yielded plants, conchostracans, semionotid and pleuropholid fishes, pterodactyloid pterosaurs, and a variety of invertebrate traces. The chronology of the Lagarcito Formation is discussed and it is concluded that this unit is of Albian age. The palaeoenvironment of deposition of the basal sequence of the Lagarcito Formation at "Loma del Pterodaustro" is interpreted as a perennial, shallow lake developed within an alluvial plain, under semiarid climatic conditions.

Chiappe, L.; Rivarola, D.; Cione, A.; Fregenal-Martinez, M.; Sozzi, H.; Buatois, L.; Gallego, O.; Laza, J.; Romero, E.; Lopez-Arbarello, A.; Buscalioni, A.; Marsicano, C.; Adamonis, S.; Ortega, F.; McGehee, S.; Di, Iorio, O.




Microsoft Academic Search

Resumen Se llevó a cabo la evaluación del cultivo de Pleurotus ostreatus, para determinar el residuo sobre el cual este hongo genera mejor crecimiento y producción. Los sustratos evaluados fueron residuos agroindustriales del departamento de Cundinamarca (capacho de uchuva, cáscara de arveja y tusa de maíz); teniendo como sustrato control el aserrín de roble. Las mezclas a evaluar fueron empacadas

Claudia López-Rodríguez; Ricardo Hernández-Corredor; Christian Suárez-Franco; Marta Borrero; Facultad de Ciencias



Origin and distribution of the BRCA2-8765delAG mutation in breast cancer  

PubMed Central

Background The BRCA2-8765delAG mutation was firstly described in breast cancer families from French-Canadian and Jewish-Yemenite populations; it was then reported as a founder mutation in Sardinian families. We evaluated both the prevalence of the BRCA2-8765delAG variant in Sardinia and the putative existence of a common ancestral origin through a haplotype analysis of breast cancer family members carrying such a mutation. Methods Eight polymorphic microsatellite markers (D13S1250, centromeric, to D13S267, telomeric) spanning the BRCA2 gene locus were used for the haplotype analysis. Screening for the 8765delAG mutation was performed by PCR-based amplification of BRCA2-exon 20, followed by automated sequencing. Results Among families with high recurrence of breast cancer (? 3 cases in first-degree relatives), those from North Sardinia shared the same haplotype whereas the families from French Canadian and Jewish-Yemenite populations presented distinct genetic assets at the BRCA2 locus. Screening for the BRCA2-8765delAG variant among unselected and consecutively-collected breast cancer patients originating from the entire Sardinia revealed that such a mutation is present in the northern part of the island only [9/648 (1.4%) among cases from North Sardinia versus 0/493 among cases from South Sardinia]. Conclusion The BRCA2-8765delAG has an independent origin in geographically and ethnically distinct populations, acting as a founder mutation in North but not in South Sardinia. Since BRCA2-8765delAG occurs within a triplet repeat sequence of AGAGAG, our study further confirmed the existence of a mutational hot-spot at this genomic position (additional genetic factors within each single population might be involved in generating such a mutation).

Palomba, Grazia; Cossu, Antonio; Friedman, Eitan; Budroni, Mario; Farris, Antonio; Contu, Antonio; Pisano, Marina; Baldinu, Paola; Sini, Maria C; Tanda, Francesco; Palmieri, Giuseppe



[Il ruolo del cervelletto nella depressione unipolare e bipolare: una rassegna delle principali evidenze neurobiologiche].  


riassunto. Evidenze derivanti da numerosi studi condotti sia su pazienti affetti da patologie cerebellari sia su soggetti sani suggeriscono che il cervelletto eserciti, oltre a un ruolo ormai ben definito nel controllo e nella regolazione delle funzioni motorie, una significativa attività di modulatore del tono dell'umore, del comportamento e delle funzioni cognitive. In questo lavoro di revisione abbiamo passato in rassegna tutti quegli studi di neuroimaging volti a indagare la presenza di alterazioni cerebellari sia morfologiche sia funzionali in pazienti affetti da disturbo bipolare (DB) e disturbo depressivo maggiore (DDM), ipotizzando l'esistenza di un meccanismo fisiopatologico alla base di questi disturbi, che coinvolga, almeno in parte, il cervelletto. Allo stesso scopo, sono stati esaminati anche quegli studi post mortem che indagavano la presenza di alterazioni cellulari e molecolari a partire da campioni di tessuto cerebellare, per esempio alterazioni delle proteine mitocondriali, della tirosin-chinasi B e del brain-derived neurotrophic factor (BDNF), del fattore di trascrizione SP4, della proteina fibrillare acida della glia (GFAP). In totale sono stati esaminati 28 studi, 12 inerenti le alterazioni morfologiche e funzionali del cervelletto nel DB, 13 inerenti le alterazioni morfologiche e funzionali del cervelletto nel DDM e 4 inerenti le alterazioni cerebellari post mortem in entrambi i disturbi. Dal nostro lavoro di revisione, in linea con quanto presente nella letteratura internazionale, emerge l'interessante ipotesi che il cervelletto funzioni come un "pacemaker emotivo" e che quindi una sua lesione potrebbe tradursi nell'incapacità dell'individuo di rimanere in equilibrio sulla sottile linea dell'eutimia, giustificando in questo modo la comparsa di profonde oscillazioni emotive sia sul versante depressivo sia su quello maniacale. PMID:25000888

Minichino, Amedeo; Bersani, Francesco Saverio; Trabucchi, Guido; Albano, Gabriella; Primavera, Martina; Delle Chiaie, Roberto; Biondi, Massimo



Haplotype analysis of the 185delAG BRCA1 mutation in ethnically diverse populations  

PubMed Central

The 185delAG* BRCA1 mutation is encountered primarily in Jewish Ashkenazi and Iraqi individuals, and sporadically in non-Jews. Previous studies estimated that this is a founder mutation in Jewish mutation carriers that arose before the dispersion of Jews in the Diaspora ?2500 years ago. The aim of this study was to assess the haplotype in ethnically diverse 185delAG* BRCA1 mutation carriers, and to estimate the age at which the mutation arose. Ethnically diverse Jewish and non-Jewish 185delAG*BRCA1 mutation carriers and their relatives were genotyped using 15 microsatellite markers and three SNPs spanning 12.5?MB, encompassing the BRCA1 gene locus. Estimation of mutation age was based on a subset of 11 markers spanning a region of ?5?MB, using a previously developed algorithm applying the maximum likelihood method. Overall, 188 participants (154 carriers and 34 noncarriers) from 115 families were included: Ashkenazi, Iraq, Kuchin-Indians, Syria, Turkey, Iran, Tunisia, Bulgaria, non-Jewish English, non-Jewish Malaysian, and Hispanics. Haplotype analysis indicated that the 185delAG mutation arose 750–1500 years ago. In Ashkenazim, it is a founder mutation that arose 61 generations ago, and with a small group of founder mutations was introduced into the Hispanic population (conversos) ?650 years ago, and into the Iraqi–Jewish community ?450 years ago. The 185delAG mutation in the non-Jewish populations in Malaysia and the UK arose at least twice independently. We conclude that the 185delAG* BRCA1 mutation resides on a common haplotype among Ashkenazi Jews, and arose about 61 generations ago and arose independently at least twice in non-Jews.

Laitman, Yael; Feng, Bing-Jian; Zamir, Itay M; Weitzel, Jeffrey N; Duncan, Paul; Port, Danielle; Thirthagiri, Eswary; Teo, Soo-Hwang; Evans, Gareth; Latif, Ayse; Newman, William G; Gershoni-Baruch, Ruth; Zidan, Jamal; Shimon-Paluch, Shani; Goldgar, David; Friedman, Eitan



A review on Balanites aegyptiaca Del (desert date): phytochemical constituents, traditional uses, and pharmacological activity.  


Balanites aegyptiaca Del. (Zygophyllaceae), known as 'desert date,' is spiny shrub or tree up to l0 m tall, widely distributed in dry land areas of Africa and South Asia. It is traditionally used in treatment of various ailments i.e. jaundice, intestinal worm infection, wounds, malaria, syphilis, epilepsy, dysentery, constipation, diarrhea, hemorrhoid, stomach aches, asthma, and fever. It contains protein, lipid, carbohydrate, alkaloid, saponin, flavonoid, and organic acid. Present review summarizes the traditional claims, phytochemistry, and pharmacology of B. aegyptiaca Del reported in scientific literature. PMID:22096319

Chothani, Daya L; Vaghasiya, H U



Parental origin of de novo chromosome 9 deletions in del(9p) syndrome  

SciTech Connect

Parental origin of de novo deletions in the short arm of chromosome 9 in patients with a clinical diagnosis of del(9p) syndrome was assessed in 13 patients using polymerase chain reaction (PCR) analysis of highly polymorphic dinucleotide repeat microsatellite markers located in the putative deleted region. The deletion was found to be of paternal origin in 9 cases and of maternal origin in the remaining 4 cases, suggesting that the molecular event resulting in the deletion occurs in both male and female gametogenesis and that genomic imprinting does not appear to play a role in the pathogenesis of del(9p) syndrome. 22 refs., 1 fig.

Micale, M.A.; Haren, J.M.; Conroy, J.M. [Case Western University School of Medicine, Clevelend, OH (United States)



A review on Balanites aegyptiaca Del (desert date): phytochemical constituents, traditional uses, and pharmacological activity  

PubMed Central

Balanites aegyptiaca Del. (Zygophyllaceae), known as ‘desert date,’ is spiny shrub or tree up to l0 m tall, widely distributed in dry land areas of Africa and South Asia. It is traditionally used in treatment of various ailments i.e. jaundice, intestinal worm infection, wounds, malaria, syphilis, epilepsy, dysentery, constipation, diarrhea, hemorrhoid, stomach aches, asthma, and fever. It contains protein, lipid, carbohydrate, alkaloid, saponin, flavonoid, and organic acid. Present review summarizes the traditional claims, phytochemistry, and pharmacology of B. aegyptiaca Del reported in scientific literature.

Chothani, Daya L.; Vaghasiya, H. U.



Energy and Momentum in Spacetime Homogeneous G$\\\\ddot{o}$del-type Metrics  

Microsoft Academic Search

Using Einstein and Papapetrou energy-momentum complexes, we explicitly\\u000acalculate the energy and momentum distribution associated with spacetime\\u000ahomogeneous G$\\\\ddot{o}$del-type metrics. We obtain that the two definitions of\\u000aenergy-momentum complexes do not provide the same result for these type of\\u000ametrics. However, it is shown that the results obtained are reduced to the\\u000aenergy-momentum densities of G$\\\\ddot{o}$del metric already available in

M. Sharif



Taphonomic alterations in upper Viséan dissepimented rugose corals from the Sierra del Castillo unit (Carboniferous, Córdoba, Spain)  

Microsoft Academic Search

Dissepimented rugose corals are common in the Sierra del Castillo Unit (upper Viséan from SW Spain). A complete taphonomic study has been made of the corals from three localities, each representing different environmental conditions: Antolín rocks are interpreted as mid-ramp and contains mainly reworked corals from reefs, Sierra del Castillo rocks are regarded as originating on a shallow-water platform, and

Sergio Rodríguez



Una nota sobre la sostenibilidad fiscal y el nexo entre los ingresos y gastos del Gobierno Colombiano  

Microsoft Academic Search

En este trabajo se analiza empíricamente la sostenibilidad fiscal en Colombia a través de las técnicas de cointegración. En particular, usando los ingresos tributarios y los gastos primarios del gobierno nacional central para el período 1990Q1 a 2008Q4 (datos reales y ajustados por el ciclo económico), en el documento se examina si las cuentas fiscales del gobierno han sido sostenibles

Ignacio Lozano; Enrique Cabrera



Acuerdos entre el gobierno central y los departamentos: una propuesta para aumentar la eficiencia del gasto público  

Microsoft Academic Search

El objetivo de este trabajo es proponer un instrumento para el seguimiento de la eficiencia del gasto público. El instrumento muestra que el gobierno central se puede apoyar en las administraciones departamentales con el fin de medir los productos del gasto. La idea central de la propuesta es que los objetivos de productividad acordados entre el nivel nacional y el

Isaac de León-Beltrán; Diego Jaramillo



Estudio Multicentrico de Prevalencia del Trastorno por Déficit de Atención e Hiperactividad en la República Argentina1  

Microsoft Academic Search

El presente es el primer estudio de prevalencia del Trastorno por Déficit de Atención realizado en la República Argentina. Se utilizó una muestra de inicial de 898 niños de 6 a 9 años correspondientes a los tres primeros años de escuelas primarias del Gran Buenos Aires que tras ser depurada quedó conformada por 801 niños de ambos sexos. Metodología: Para

Ruben O. Scandar



Microsoft Academic Search

2 RESUMEN Se estudia e ilustra la morfología del polen de las familias Acanthaceae, Vitaceae y Violaceae pertenecientes a la flora del Valle de México; la primera está representada por: Acanthus mollis L., Anisacanthus quadrifidus (Vahl) Standley, Dicliptera peduncularis Nees, Dyschoriste decumbens (Gray) O. Ktze., D. microphylla (Cav.) O. Ktze., Justicia furcata Jacq., Pseuderanthemum praecox (Benth.) Leonard, Ruellia bourgaei Hemsl.,




EPA Science Inventory

EPA has developed a technology transfer handbook for the EMPACT Paso del Norte Project. The EMPACT Paso del Norte Environmental Monitoring Project is a mobile vehicle emissions project that involves the international community of El Paso, TX; Sundland Park, NM; and Juarez, Mexico...


Identification of a NBD1-binding pharmacological chaperone that corrects the trafficking defect of F508del-CFTR.  


Most cases of cystic fibrosis (CF) are attributable to the F508del allele of CFTR, which causes the protein to be retained in the endoplasmic reticulum (ER) and subsequently degraded. One strategy for CF therapy is to identify corrector compounds that help traffic F508del-CFTR to the cell surface. Pharmacological chaperones, or correctors that bind specifically to F508del-CFTR and restore function, would be the most promising drug development candidates, but few pharmacological chaperones exist for F508del-CFTR. Using differential scanning fluorimetry (DSF), we have surveyed corrector compounds and identified one, RDR1, which binds directly to the first nucleotide binding domain (NBD1) of F508del-CFTR. We show that RDR1 treatment partially rescues F508del-CFTR function in both cells and in an F508del-CF mouse model. Thus, RDR1 is a pharmacological chaperone of F508del-CFTR and represents a novel scaffold for drug development. PMID:21338920

Sampson, Heidi M; Robert, Renaud; Liao, Jie; Matthes, Elizabeth; Carlile, Graeme W; Hanrahan, John W; Thomas, David Y



El espejismo del desarrollo y la globalización económica en los países de América Latina. (Axe II, Symposium 8)  

Microsoft Academic Search

El presente trabajo tiene el objetivo de reflexionar sobre el discurso del concepto de “globalización económica” que conlleva la ilusión de ofrecer un “desarrollo económico” que no es equivalente a lo que denominamos “desarrollo total” de una sociedad, ya que éste se refiere sólo a una dimensión parcial del proceso: la estrictamente económica. El cuestionamiento que nos hacemos es ¿Por

Marco Antonio Merchand




Microsoft Academic Search

Se tuvo como objetivo la propuesta de un sistema de indicadores para la evaluación de la aplicación del Sistema de Gestión Ambiental en empresas constructoras y la elaboración de un software para el procesamiento de los mismos, que contribuya a elevar la eficacia de la evaluación del desempeño ambiental y los resultados de las organizaciones de este tipo. Este sistema

Ninfa del Carmen Moncada Serrano



Evaluación del ciclo de vida aplicada en agrocadenas productivas: un instrumento de gestión ambiental para el diseño de políticas  

Microsoft Academic Search

La Evaluación del Ciclo de Vida del Producto (ECV) ha sido sugerida como un instrumento adecuado para ampliar el análisis y formulación de estrategias y políticas al utilizar el enfoque de Cadenas Globales de Mercancías. En este artículo se analizan los alcances de la aplicación de la ECV en diferentes sistemas de gestión ambiental lo cual permite establecer las áreas

Rafael Díaz Porras; Marjorie Hartley Ballestero



Gestión para el desarrollo local sostenible en Granjas Agroindustriales y Empresas Azucareras del MINAZ de la provincia de Cienfuegos  

Microsoft Academic Search

La investigación se realizó en las entidades del MINAZ, teniendo como título: “Gestión para el desarrollo local sostenible en Granjas Agroindustriales y Empresas Azucareras del MINAZ en la provincia de Cienfuegos”. Tiene como objetivo general proponer un sistema de gestión ambiental integral que permita valorar e implantar las políticas de desarrollo local sostenible de las granjas agroindustriales y empresas azucareras

Eduardo Julio López Bastida; Mileisy Balbis Morejón



Carta abierta a las organizaciones y personas que trabajan en el área del cáncer acerca de los estudios clínicos en la comunidad

El doctor Varmus reafirma el compromiso del NCI con los pacientes que participan en estudios clínicos en la comunidad y explica en qué consiste la transición al nuevo Programa de Investigación Oncológica Comunitaria del NCI (NCORP).


["Legal highs": paradisi sicuri e legali? Uno studio sulla diffusione, conoscenza e consapevolezza del rischio delle nuove droghe psicoattive tra gli studenti del Regno Unito].  


RIASSUNTO. Introduzione. La recente comparsa delle nuove sostanze ricreazionali, combinata alla possibilità offerta da Internet di diffondere le informazioni velocemente, ha sollevato numerose nuove preoccupazioni nel campo legislativo, nel campo della ricerca sulle nuove sostanze e per quanto riguarda la salute pubblica. Metodi. È stato utilizzato un questionario semistrutturato pubblicizzato sul sito di Study Room da novembre a dicembre 2010 per esplorare la consapevolezza, l'uso e la percezione di rischio delle "legal highs" tra la popolazione studentesca nel Regno Unito. Risultati. Un terzo (31,40%) dei 446 partecipanti ha riferito l'uso di queste sostanze. Gli intervistati hanno riferito soprattutto l'uso di: mefedrone (41,4%), Salvia divinorum (20%), "spice drugs" (10,7%), metilone (1,4%), nafirone (NRG) (2,1%) e benzilpiperazina (BZP) (2,1%), mentre il 15,7% non sapeva che tipo di composto avesse assunto. La maggioranza (78,9%) considerava queste sostanze "legali", mentre il 74,2% non le considerava più sicure di composti illegali. Metà del campione (50,8%) era consapevole della presenza di componenti illegali nei prodotti consumati. Conclusioni. Lo studio contribuisce al tentativo di stimare l'uso e la consapevolezza del rischio in merito alle nuove sostanze psicoattive tra gli studenti del Regno Unito. Si ritengono necessari ulteriori studi, soprattutto in termini di personalità e stili di vita, al fine di inquadrare meglio queste nuove forme di abuso, anche in setting non propriamente ricreazionali. PMID:24770577

Corazza, Ornella; Simonato, Pierluigi; Corkery, John; Trincas, Giuseppina; Schifano, Fabrizio



El trabajo político e ideológico en la universidad cubana de hoy. El socialismo en las nuevas condiciones del siglo XXI: una opción viable  

Microsoft Academic Search

Un objetivo de primer orden en todos los años de Revolución ha sido lograr en los graduados universitarios la formación integral de un profesional revolucionario. Los cambios operados en la situación internacional después del derrumbe del campo socialista y la desaparición de la URSS así como el incremento de la agresividad económica e ideológica del gobierno de Estados Unidos y

Anay Pulgarón Ramos



Valoración de impactos socio- ambientales del arbolado urbano: una aplicación a la ciudad de Santiago, Chile  

Microsoft Academic Search

Santiago de Chile es tercero en la lista de ciudades más contaminadas de Latinoamérica, después de Ciudad de México y Sao Paulo, por lo cual la valoración ambiental y social del arbolado urbano en este contexto es de vital importancia. Los proyectos de arbolado urbano ya sea en calles, plazas, parques u otras áreas verdes tienen como propósito, por una

Carmen L. De la Maz; Claudia L. Cerd



Integrated global background monitoring network. Preliminary results from Torres del Paine and Olympic National Parks  

Microsoft Academic Search

During 1984, a pilot project was initiated for monitoring pollution at Torres del Paine National Park in southern Chile and Olympic National Park in the United States. These are two of three initial sites that are to be established as part of an integrated global backgound monitoring network. Eventually, the plan is to establish a world-wide system of such sites.

G. B. Wiersma; A. Kohler; C. Boelcke; G. Baker; M. Harmon; C. Weber; J. Gonzales



Efectos heterogéneos del trabajo infantil en la adquisición de habilidades cognitivas  

Microsoft Academic Search

El estudio se ocupa de los efectos heterogéneos del trabajo en la formación de capital humano a través de una definición amplia de trabajo que incluye toda actividad asociada a responsabilidades no escolares. Dada la variedad de responsabilidades asumidas por niños y adolescentes peruanos, se toma en cuenta dos criterios para clasificar los diferentes tipos de trabajo: el tipo de

Carmen Ponce



Las políticas públicas de fomento del reciclaje: La regeneración de aceites usados  

Microsoft Academic Search

Los aceites usados son un residuo peligroso del que pueden derivarse graves daños medioambientales si su gestión es inadecuada; al mismo tiempo, tienen un indudable valor económico, ya que conservan gran parte de los hidrocarburos que los lubricantes contenían originalmente. La gestión de los aceites usados ofrece distintas alternativas, dirigidas principalmente al reciclaje, siendo de destacar la combustión y la

Asunción Arner Güerre; Ramón Barberán Ortí; Jesús Mur Lacambra



A tectonically controlled basin-fill within the Valle del Cauca, West-Central Colombia  

SciTech Connect

Tertiary strata of the Valle del Cauca reflect a forearc/foreland basin tectonic history spanning a period from pre-uplift of the Cordillera Central to initiation of uplift of the Cordillera Occidental. Stratigraphy of the Valle del Cauca begins with Jurassic-Cretaceous rocks of exotic and/or volcanic provenance and of oceanic origin. Unconformably overlying these are Eocene to Oligocene basal quartz-rich sandstones, shallow marine algal limestones, and fine-grained fluvial/deltaic mudstones and sandstones with coalbeds. These Eocene to Oligocene deposits represent a period of low tectonic activity. During late Oligocene to early Miocene, increased tectonic activity produced conglomeratic sediments which were transported from east to west, apparently derived from uplift of the Cordillera Central, and deposited within a fluvial to deltaic setting. East-west shortening of the Valle del Cauca basin folded the Eocene to early Miocene units, and additional uplift of the Cordillera Central during the later Miocene resulted in syn-tectonic deposition of alluvial fans. After additional fold and thrust deformation of the total Eocene-Miocene basin-fill, tectonic activity abated and Pliocene-Quaternary alluvial and lacustrine strata were deposited. Within the framework of this depositional and tectonic history of the Valle del Cauca, hydrocarbon exploration strategies can be formulated and evaluated.

Rine, J.M.; Keith, J.F. Jr.; Alfonso, C.A.; Ballesteros, I.; Laverde, F.; Sacks, P.E.; Secor, D.T. Jr. (Univ. of South Carolina, Columbia (United States)); Perez, V.E.; Bernal, I.; Cordoba, F.; Numpaque, L.E. (Ecopetrol, Bogota (Colombia))



Integrated Global Background Monitoring Network. Preliminary Results from Torres Del Paine and Olympic National Parks.  

National Technical Information Service (NTIS)

During 1984, a pilot project was initiated for monitoring pollution at Torres del Paine National Park in southern Chile and Olympic National Park in the United States. These are two of three initial sites that are to be established as part of an integrate...

G. B. Wiersma A. Kohler C. Boelcke G. Baker M. Harmon



Acantholachesilla gen. n. (Psocodea:'Psocoptera': Lachesillidae: Eolachesillinae: Graphocaeciliini) from Valle del Cauca, Colombia.  


Acantholachesilla saltoensis gen. et sp. n. is described from Valle del Cauca, Colombia, in the Lachesillidae, tribe Graphocaeciliini (Eolachesillinae). The genus is related to Dagualachesilla and Dagualachesilloides that occur in the same area, differing from them in the male clunial projection, phallosome, and female subgenital plate and gonapophyses. PMID:24989767

Aldrete, Alfonso N García; Manchola, Oscar Fernando Saenz; Obando, Ranulfo González



¿Competencia o colusión en el mercado de gasolina? Una aproximación a través del parámetro de conducta  

Microsoft Academic Search

Este trabajo analiza la competencia en el mercado minorista de gasolinas. Para ello nos centramos en el mercado de las Islas Canarias porque ofrece dos ventajas inéditas respecto de otros mercados: la facilidad en la definición del mercado relevante (insular) y la existencia de mercados en monopolio y en oligopolio simultáneamente. Este último hecho permite estimar un modelo de variaciones

Jordi Perdiguero; Juan Luis Jiménez



La culpa es del Yankee: Correlaciones e ineficiencias en el mercado de dinero  

Microsoft Academic Search

Los cambios en las tasas de interés de los bonos globales colombianos -mecanismo de transmisión de las presiones de los mercados internacionales sobre el mercado localson los principales causantes de las fluctuaciones en el mercado de dinero doméstico. Este fenómeno parece haberse acentuado incluso después de que los problemas del mercado de TES de fin de 2002 indujeron la conformación

Santiago Gutiérrez V; Michel Formisano P



Historia de la investigación marina de la Isla del Coco Costa Rica  

Microsoft Academic Search

Abstract: History of marine research at Cocos Island, Costa Rica. The marine organisms and environments ofIsla del Coco (Cocos Island), Pacific Costa Rica, were described by explorers in the late 17, century, during the Albatross Expeditions. The first expedition by Costa Rican scientists was in 1898. Between the 1920’s and 1940’s, many expeditions visited the island and many papers were

Jorge Cortés


La reordenación y reducción del tiempo de trabajo en la Unión Europea  

Microsoft Academic Search

Si hasta la primera mitad de la década de los 80, eran las reivindicaciones sindicales en materia de reducción del tiempo de trabajo las que propiciaban acuerdos de reducción de las jornadas de trabajo y legislaciones de trabajo tendentes a reducir las joranadas máximas legales e incrementar el número de días de vacaciones anuales, con la liberalización e internacionalización de

Luis A. Rasines García; Iñigo Renovales Mota




Microsoft Academic Search

En los últimos años se ha discutido el papel de los gobiernos subnacionales como entes tomadores de decisiones y generadores de política en diversos ámbitos, considerando que las prácticas novedosas y la participación de diversos actores gubernamentales y no gubernamentales son un factor detonante del desarrollo en el diseño e implementación de política pública. Estas nuevas formas —entendidas como innovación—

Mario E. Ibarra Cortés; Erika García Méndez



Las corporaciones autonomas regionales del caribe colombiano: Un analisis de sus finanzas y gobierno corporativo  

Microsoft Academic Search

Las Corporaciones Autónomas Regionales (car) y las Corporaciones de Desarrollo Sostenible (cds) son las instituciones encargadas de la protección del medio ambiente en Colombia. Este trabajo estudia el desempeño de las corporaciones que tienen jurisdicción sobre la Costa Caribe. En particular, examina sus principales fortalezas y limitaciones administrativas, y analiza si en sus presupuestos se reproducen las desigualdades regionales que

Joaquin Viloria de la Hoz



Innovazione, finanza e sviluppo: aspetti del dibattito teorico e dell'evidenza empirica  

Microsoft Academic Search

Innovazione, finanza e sviluppo: aspetti del dibattito teorico e dell'evidenza empirica (di Ferruccio Bresolin) - ABSTRACT: According to Schumpeter, one of the most important problems of innovation is the search for new financial resources to dedicate to research, experimentation and innovation. The aim of this article is to provide a summary on the subject of the discussion concerning the problems

Ferruccio Bresolin



Diagnóstico y tratamiento farmacológico del trastorno por déficit de atención e hiperactividad  

Microsoft Academic Search

. Se asocia con retraso y dificultades del funcionamiento académico y social 2 , y hay evidencia creciente que indica que también se asocia con morbilidad significativa y peor funcionamiento en la edad adulta 3,4 . Además, estudios longitudinales recientes señalan que los niños con TDAH de ambos sexos y de cual- quier edad generan un gasto médico total y

César Soutullo Esperón



A Failed Utopia in Marcela Del Río's "Proceso a Faubritten"  

ERIC Educational Resources Information Center

In Marcela del Río's science fiction novel "Proceso a Faubritten," utopia comes in the form of eternal life for all of humanity, thanks to Dr. Alexander Faubritten's "Bomba L." This polyphonic work includes diaries by Faubritten and his Mexican lover, María Corona. In my analysis of these two diaries, I will show how…

Manickam, Samuel



Genetics of Suicidal Germination of Striga hermonthica (Del.) Benth by Cotton  

Microsoft Academic Search

of the crop and abandonment of otherwise productive fields (Butler, 1995). Well over a decade ago, a conserva- The germination of giant witchweed (Striga hermonthica (Del.) tive estimate of crop losses due to Striga in Africa was Benth), a noxious root parasite of many cereal crops, is stimulated by exudates from the roots of both host and non-host trap plants.

C. J. Botanga; S. O. Alabi; C. A. Echekwu; S. T. O. Lagoke


Las fundaciones de ciudades y el pensamiento urbanístico hispano en la era del Descubrimiento  

Microsoft Academic Search

La historia urbana referida al periodo histórico en torno a la fecha de 1492, con sus precedentes, desde la caída de Constantinopla (1452) y su evolución hasta la entronización y asentamiento de la monarquía del Emperador Carlos (~1530), es un periodo excepcional que requiere una reinterpretación a la luz de nuevos enfoques interdisciplinarios y de nuevos descubrimientos científicos. El periodo

María Isabel Navarro Segura



Sistemi informativi geografici come estensione del Customer Relationship Management nelle imprese e nei servizi  

Microsoft Academic Search

Sistemi informativi geografici come estensione del Customer Relationship Management nelle imprese e nei servizi (di Federica Tombari) - ABSTRACT: The paper illustrates the increasing opportunities related to the adoption of Geographic Information Systems (GIS) with the potential of Customer Database (CDB) and Customer Relationship Management (CRM) in the traditional analysis for the support decision system in the business management of

Federica Tombari



El Instituto Nacional del Cáncer lanza el sitio en la Internet

El Instituto Nacional del Cáncer (NCI, por sus siglas en ingls) anunci hoy el lanzamiento de (, que ha sido mejorado significativamente, es muy fcil de navegar y brinda en un solo sitio toda la informacin sobre el cáncer


Ouabain Mimics Low Temperature Rescue of F508del-CFTR in Cystic Fibrosis Epithelial Cells.  


Most cases of cystic fibrosis (CF) are caused by the deletion of a single phenylalanine residue at position 508 of the cystic fibrosis transmembrane conductance regulator (CFTR). The mutant F508del-CFTR is retained in the endoplasmic reticulum and degraded, but can be induced by low temperature incubation (29°C) to traffic to the plasma membrane where it functions as a chloride channel. Here we show that, cardiac glycosides, at nanomolar concentrations, can partially correct the trafficking of F508del-CFTR in human CF bronchial epithelial cells (CFBE41o-) and in an F508del-CFTR mouse model. Comparison of the transcriptional profiles obtained with polarized CFBE41o-cells after treatment with ouabain and by low temperature has revealed a striking similarity between the two corrector treatments that is not shared with other correctors. In summary, our study shows a novel function of ouabain and its analogs in the regulation of F508del-CFTR trafficking and suggests that compounds that mimic this low temperature correction of trafficking will provide new avenues for the development of therapeutics for CF. PMID:23060796

Zhang, Donglei; Ciciriello, Fabiana; Anjos, Suzana M; Carissimo, Annamaria; Liao, Jie; Carlile, Graeme W; Balghi, Haouaria; Robert, Renaud; Luini, Alberto; Hanrahan, John W; Thomas, David Y




Microsoft Academic Search

Se presentan los avances de la investigacion doctoral con los resultados del estudio piloto. En la primera fase se obtuvo la opinion de un grupo de expertos de las habilidades que requieren tener los jefes de deprtamento, los subdirectores y directores para desempeñarse en su funcion. En una segunda fase se toma una muestra representativa de los directivos de los

Gloria Pérez Garmendia; Francisco Gerardo Barroso Tanoira; José Juan Escalante Fernández; Hortensia Eliseo Dantes



Il quadro finanziario pluriennale dell'Unione e la costruzione del processo di integrazione europea  

Microsoft Academic Search

Il quadro finanziario pluriennale dell'Unione e la costruzione del processo di integrazione europea (di Silvano Presa) - ABSTRACT: This paper assesses how the eu budget is going to be shaped over the next decade in view of meeting the challenge of growth. Firstly, the paper briefly recalls the main features of the European Union’s public finances. Secondly, it highlights the

Silvano Presa



Design, Development and Optimization of Highly Efficient Solar Cars: Gato del Sol I-IV  

Microsoft Academic Search

Engineering students at the University of Kentucky have designed and built solar powered cars for the 2008 North American Solar Challenge and the 2009 Formula Sun Grand Prix. Gato del Sol III, our most accomplished car, is powered by a solar array of 480 Silicon monocrystalline photovoltaic cells. Maximum Power Point trackers efficiently made use of these cells and tracked

Raghu Mangu; Krishna Prayaga; Bhavananda Nadimpally; Sam Nicaise




Microsoft Academic Search

RESUMEN Este artículo propone el diseño de un sistema de adquisición de datos con componentes digitales y analógicos microelectrónicos reconfigurables, como son el FPGA (Field Programmable Gate Array) y el FPAA (Field Programmable Analog Array), para monitorear y analizar la contaminación por ruido ambiental. Este prototipo obtiene los datos del ruido de una zona vial (zona centro de una ciudad)

A. Castillo Atoche; J. Vázquez Castillo; V. Sanchez Huerta; P. Del Río Dawn


33 CFR 162.200 - Marina del Rey, Calif.; restricted area.  

Code of Federal Regulations, 2013 CFR

...REGULATIONS § 162.200 Marina del Rey, Calif.; restricted area. (a) The area . That portion of the Pacific Ocean lying shoreward of the offshore breakwater and the most seaward 1,000 feet of the entrance channel between the north and...




Microsoft Academic Search

In many ways the Jewish community of San Daniele del Friuli enjoyed a fortunate existence compared with Jews in other settlements in the region. They were protected from the patriarchs, whose jurisdiction in San Daniele continued even after the Venetian Conquest (1420), owing to the churchstate accord of 1445. The Jews took fair advantage of this situation, in fact no

Lara Pironio



Indicadores de riesgo y de gestión del riesgo de los desastres: resultados para Nicaragua  

Microsoft Academic Search

Los desastres naturales han repercutido en las perspectivas de desarrollo de muchos de los países de América Latina y el Caribe. Nicaragua está al frente de esta infortunada realidad, estando localizada en una de las zonas del mundo más propensa a amenazas naturales. Con el fin de apoyar a Nicaragua es reducir su vulnerabilidad frente a las amenazas y las

Omar D. Cardona




Microsoft Academic Search

La supervivencia de la especie humana es inconcebible sin aquello que aporta el medio ambiente. Pese a ello los seres humanos hemos tendido, con el paso del tiempo, a despreciar su importancia, realizando nuestras actividades sin considerar nuestro impacto sobre él. La configuración de un sistema energético basado en la mala gestión de los recursos naturales, muchas veces utilizados a

Leonardo Granato; Nahuel Oddone; Adolfo Carballo Penela




Microsoft Academic Search

Sommario Nel presente studio è proposta l'analisi sperimentale, mediante ultrasuoni, del contatto tra un indentatore cilindrico piano a bordi raccordati ed un piano, problema per il quale è stata recentemente proposta una soluzione analitica mai validata sperimentalmente. Per ciascun accoppiamento è stata valutata la riflessione dall'interfaccia, che è noto essere in relazione con lo stato di contatto. I risultati sperimentali

B. Leban; M. Pau; A. Baldi; F. Ginesu



Microsoft Academic Search

El P. Antonio Soler tuvo al menos un hermano que también era músico y compositor: Mateo Soler, que actuó como fagotista de la Real Capilla en Madrid de 1780 a 1799, año en que murió. Damos cuenta de los pormenores biográficos tanto familiares como profesionales que hemos podido averiguar sobre este músico olvidado, del que incluso se conserva una sonata

Guy Bourligueux



An Accretion-Disc Model for the Algol-Type Eclipsing Binary System AV Del  

Microsoft Academic Search

This study inspects the light and radial-velocity curves of the eclipsing binary AV Del. In comparison with other studies already done, the study shows that the absolute elements, fundamental orbital and physical parameters of the system can be determined using the Wilson-Devinney code. Using these parameters, the configuration of the system is presented. Then, an accretion disc model for the

S. M. R. Ghoreyshi; J. Ghanbari; F. Salehi



Dropouts, Stopouts, Optouts at Del Mar College: Spring 1991. Report of a Joint Research Project.  

ERIC Educational Resources Information Center

A research project investigated 2,313 persons who attended Del Mar College (Texas) during fall 1990 but did not enroll for spring 1991. Four sets of data were collected: (1) limited demographic information on the total student body; (2) demographic information drawn from school records to describe all nonreturnees; (3) demographic information…

Luckie, Jo Ann I.; Bonham, L. Adrianne


Nutrición deportiva en la infancia: Cumplimiento de las demandas metabólicas del crecimiento y el ejercicio  

Microsoft Academic Search

ExtractoLos objetivos fundamentales de la infancia son el crecimiento y la maduración óptimos. Estos procesos relacionados con el desarrollo exigen un balance energético y nitrogenado positivo. Aunque la actividad física regular puede intensificar el desarrollo en la infancia, un entrenamiento físico extenuante puede reducir las reservas de energía y nitrógeno del organismo que, entonces, deberán reemplazarse a través de la

C. L. Zanker



Declaración sobre los cambios que tendrán lugar próximamente en los programas de estudios clínicos del NCI

Los estudios clínicos son elementos fundamentales en la transformación de los descubrimientos científicos en métodos prácticos para prevenir y tratar el cáncer. En esta declaración, hacemos un resumen de los cambios que están teniendo lugar en las organizaciones que realizan estudios clínicos bajo los auspicios del NCI.



EPA Science Inventory

Ambient air VOC samples were collected at surface air quality monitoring sites, near sources of interest, and aloft on the US (El Paso) and Mexican (Ciudad Juarez) side of the border during a six-week period of the 1996 Paso del Norte Ozone Study. Samples were collected at five...


Is CFTR-delF508 Really Absent from the Apical Membrane of the Airway Epithelium?  

PubMed Central

Background Understanding where mutant CFTR is localised in airway epithelia is essential in guiding the best therapeutic approach to correct the dysfunction of the CFTR protein. The widely held paradigm is that CF patients harbouring the commonest mutation, CFTR-delF508, trap CFTR within the endoplasmic reticulum and target it for degradation. However there are conflicting reports concerning expression and localisation of CFTR-delF508 in lung tissue. To attempt to resolve this fundamental issue we developed a novel approach to measure CFTR-delF508 in the lower airways of patients who have undergone lung transplantation for advanced CF. By sampling CF and non-CF epithelium simultaneously from the same individual, confounding factors of different airway microenvironments which may have influenced previous observations can be overcome. Methods Epithelia sampled by bronchial brushing above (CF) and below (non-CF) the bronchial anastomosis were stained for CFTR and the localisation and level of expression assessed (n?=?12). Results There was no significant difference in the proportion of tall columnar cells showing CFTR immunostaining as a discrete band at the apical membrane in cells harbouring the CFTR-delF508 mutation compared to non-CF cells (p?=?0.21, n?=?12). However, the amount of CFTR expressed at the apical surface was reduced by ?50% in CF cells compared to non-CF cells (p?=?0.04, n?=?5). Conclusions Our novel observation challenges the prevailing paradigm that CFTR is essentially absent from the apical membrane of respiratory cells harbouring the CFTR-delF508 mutation. Moreover, it raises the possibility that the new generation of CFTR potentiators may offer a realistic therapeutic option for CF patients.

Borthwick, Lee A.; Botha, Phil; Verdon, Bernard; Brodlie, Malcolm J.; Gardner, Aaron; Bourn, David; Johnson, Gail E.



A chemical corrector modifies the channel function of F508del-CFTR.  


The deletion of Phe-508 (F508del) constitutes the most prevalent cystic fibrosis-causing mutation. This mutation leads to cystic fibrosis transmembrane conductance regulator (CFTR) misfolding and retention in the endoplasmic reticulum and altered channel activity in mammalian cells. This folding defect can however be partially overcome by growing cells expressing this mutant protein at low (27 degrees C) temperature. Chemical "correctors" have been identified that are also effective in rescuing the biosynthetic defect in F508del-CFTR, thereby permitting its functional expression at the cell surface. The mechanism of action of chemical correctors remains unclear, but it has been suggested that certain correctors [including 4-cyclohexyloxy-2-(1-[4-(4-methoxy-benzenesulfonyl)-piperazin-1-yl]-ethyl)-quinazoline (VRT-325)] may act to promote trafficking by interacting directly with the mutant protein. To test this hypothesis, we assessed the effect of VRT-325 addition on the channel activity of F508del-CFTR after its surface expression had been "rescued" by low temperature. It is noteworthy that short-term pretreatment with VRT-325 [but not with an inactive analog, 4-hydroxy-2-(1-[4-(4-methoxy-benzenesulfonyl)-piperazin-1-yl]-ethyl)-quinazoline (VRT-186)], caused a modest but significant inhibition of cAMP-mediated halide flux. Furthermore, VRT-325 decreased the apparent ATP affinity of purified and reconstituted F508del-CFTR in our ATPase activity assay, an effect that may account for the decrease in channel activity by temperature-rescued F508del-CFTR. These findings suggest that biosynthetic rescue mediated by VRT-325 may be conferred (at least in part) by direct modification of the structure of the mutant protein, leading to a decrease in its ATP-dependent conformational dynamics. Therefore, the challenge for therapy discovery will be the design of small molecules that bind to promote biosynthetic maturation of the major mutant without compromising its activity in vivo. PMID:20501743

Kim Chiaw, Patrick; Wellhauser, Leigh; Huan, Ling Jun; Ramjeesingh, Mohabir; Bear, Christine E



DelsGate, a robust and rapid gene deletion construction method.  


With the increasing availability of fungal genome sequences there is great demand for fast, simple high-throughput methods to generate constructs for gene deletion. Here we describe a method that combines PCR and Gateway cloning technology together with use of the I-SceI homing endonuclease to generate precise deletion constructs in a very simple, universal and robust manner in just 2 days. These constructs are then used to produce deletion mutants in the organism of interest following applicable methods for that species. In establishing this protocol we determined empirically that 1 kb was a suitable flank length to facilitate homologous recombination in our species of interest, Ustilago maydis. The method, which we have named DelsGate (Deletions via Gateway), consists of standard PCR of only the 5' and 3' 1 kb gene flanks directly followed by in vitro Gateway cloning and final generation of the circular deletion construct by in vivo recombination in Escherichia coli. For use in DelsGate we have modified a Gateway cloning vector to include selectable markers for transformation of Ascomycetes and the Basidiomycete fungus U. maydis which causes corn smut disease. We have tested the reproducibility of the DelsGate approach by generating deletion constructs for 12 U. maydis genes. Although not tested here, the PCR and transformation steps of DelsGate should be well suited for high-throughput approaches to gene deletion construction in fungal species. DelsGate has the potential to be universal for all organisms with efficient transformation and homologous recombination systems. PMID:18248826

García-Pedrajas, María D; Nadal, Marina; Kapa, Laura B; Perlin, Michael H; Andrews, David L; Gold, Scott E



Percepcion de los profesores universitarios acerca del concepto cultura cientifica y de sus implicaciones en el nuevo bachillerato del Recinto de Rio Piedras de la Universidad de Puerto Rico  

NASA Astrophysics Data System (ADS)

El Senado Academico del Recinto de Rio Piedras de la Universidad de Puerto Rico aprobo en el ano academico 2005-2006 la Certificacion 46, que contiene los lineamientos de un nuevo bachillerato. Este nuevo bachillerato introdujo cambios significativos en el curriculo tradicional. Entre ellos se encuentra la reduccion del componente de educacion general y el de Ciencias Biologicas en particular. La reduccion de creditos en el componente de Ciencias Biologicas ha obligado a reevaluar el concepto de cultura cientifica que desarrollan esos cursos. El proposito del estudio consistio en auscultar las percepciones de los profesores de las Facultades de Administracion de Empresas, Humanidades, Ciencias Sociales, Ciencias Naturales, Educacion y Estudios Generales del Recinto de Rio Piedras de la Universidad de Puerto Rico en torno al concepto de cultura cientifica, los contenidos disciplinares del curso de Ciencias Biologicas y la reduccion de creditos en el nuevo bachillerato. Las preguntas que guiaron la investigacion fueron: ¿cuales son las percepciones que tienen los profesores de las Facultades de Administracion de Empresas, Ciencias Sociales, Estudios Generales, Ciencias Naturales, Humanidades y Educacion, en torno al concepto de cultura cientifica y los contenidos disciplinares del curso de Ciencias Biologicas? ¿cuales son las percepciones que tienen los profesores de Ciencias Biologicas en torno al concepto cultura cientifica y los contenidos disciplinares del curso de Ciencias Biologicas? ¿existen diferencias significativas por facultad, genero, experiencia, rango y nombramiento en las percepciones que tienen los profesores del Recinto de Rio Piedras de la Universidad de Puerto Rico sobre los elementos que caracterizan la cultura cientifica y los contenidos biologicos que deben tener los egresados del Recinto? ¿que implicaciones curriculares tienen estos testimonios en el desarrollo del concepto de cultura cientifica en el nuevo bachillerato? Para realizar la investigacion se utilizo una metodologia cuantitativa y la herramienta para lograrlo fue una encuesta. La encuesta se analizo estadisticamente mediante analisis de frecuencias y por cientos, prueba ANOVA, prueba t, pruebas Post Hoc de Tukey y de Levene. Tambien se realizo nuevamente una prueba de confiabilidad mediante el alfa de Cronbach. Los resultados reflejaron que los profesores de las Facultades de Administracion de Empresas, Ciencias Sociales, Ciencias Naturales, Educacion, Humanidades, Estudios Generales y el Departamento de Ciencias Biologicas tienen una percepcion muy positiva del concepto de cultura cientifica, los contenidos curriculares de Ciencias Biologicas y del nuevo bachillerato.

Ramos Pastrana, Nilsa


Yeast DEL Assay Detects Protection against Radiation-Induced Cytotoxicity and Genotoxicity: Adaptation of a Microtiter Plate Version  

PubMed Central

The DEL assay in yeast detects DNA deletions that are inducible by many carcinogens. Here we use the colorimetric agent MTS to adapt the yeast DEL assay for microwell plate measurement of ionizing radiation-induced cell killing and DNA deletions. Using the microwell-based DEL assay, cell killing and genotoxic DNA deletions both increased with radiation dose between 0 and 2000 Gy. We used the microwell-based DEL assay to assess the effectiveness of varying concentrations of five different radioprotectors, N-acetyl-l-cysteine, l-ascorbic acid, DMSO, Tempol and Amifostine, and one radiosensitizer, 5-bromo-2-deoxyuridine. The microwell format of the DEL assay was able to successfully detect protection against and sensitization to both radiation-induced cytotoxicity and genotoxicity. Such radioprotection and sensitization detected by the micro-well-based DEL assay was validated and compared with similar measurements made using the traditional agar-based assay format. The yeast DEL assay in microwell format is an effective tool for rapidly detecting chemical protectors and sensitizers to ionizing radiation and is automatable for chemical high-throughput screening purposes.

Hafer, Kurt; Rivina, Yelena; Schiestl, Robert H.



Trimethylangelicin promotes the functional rescue of mutant F508del CFTR protein in cystic fibrosis airway cells.  


Cystic fibrosis transmembrane conductance regulator (CFTR) carrying the F508del mutation is retained in endoplasmic reticulum and fails to traffic to the cell surface where it functions as a protein kinase A (PKA)-activated chloride channel. Pharmacological correctors that rescue the trafficking of F508del CFTR may overcome this defect; however, the rescued F508del CFTR still displays reduced chloride permeability. Therefore, a combined administration of correctors and potentiators of the gating defect is ideal. We recently found that 4,6,4'-trimethylangelicin (TMA), besides inhibiting the expression of the IL-8 gene in airway cells in which the inflammatory response was challenged with Pseudomonas aeruginosa, also potentiates the cAMP/PKA-dependent activation of wild-type CFTR or F508del CFTR that has been restored to the plasma membrane. Here, we demonstrate that long preincubation with nanomolar concentrations of TMA is able to effectively rescue both F508del CFTR-dependent chloride secretion and F508del CFTR cell surface expression in both primary or secondary airway cell monolayers homozygous for F508del mutation. The correction effect of TMA seems to be selective for CFTR and persisted for 24 h after washout. Altogether, the results suggest that TMA, besides its anti-inflammatory and potentiator activities, also displays corrector properties. PMID:24816489

Favia, Maria; Mancini, Maria T; Bezzerri, Valentino; Guerra, Lorenzo; Laselva, Onofrio; Abbattiscianni, Anna C; Debellis, Lucantonio; Reshkin, Stephan J; Gambari, Roberto; Cabrini, Giulio; Casavola, Valeria



CHEK2*1100delC homozygosity in the Netherlands--prevalence and risk of breast and lung cancer.  


The 1100delC mutation in the CHEK2 gene has a carrier frequency of up to 1.5% in individuals from North-West Europe. Women heterozygous for 1100delC have an increased breast cancer risk (odds ratio 2.7). To explore the prevalence and clinical consequences of 1100delC homozygosity in the Netherlands, we genotyped a sporadic breast cancer hospital-based cohort, a group of non-BRCA1/2 breast cancer families, and breast tumors from a tumor tissue bank. Three 1100delC homozygous patients were found in the cohort of 1434 sporadic breast cancer patients, suggesting an increased breast cancer risk for 1100delC homozygotes (odds ratio 3.4, 95% confidence interval 0.4-32.6, P=0.3). Another 1100delC homozygote was found in 592 individuals from 108 non-BRCA1/2 breast cancer families, and two more were found after testing 1706 breast tumors and confirming homozygosity on their wild-type DNA. Follow-up data was available for five homozygous patients, and remarkably, three of them had developed contralateral breast cancer. A possible relationship between 1100delC and lung cancer risk was investigated in 457 unrelated lung cancer patients but could not be confirmed. Due to the small number of 1100delC homozygotes identified, the breast cancer risk estimate associated with this genotype had limited accuracy but is probably higher than the risk in heterozygous females. Screening for CHEK2 1100delC could be beneficial in countries with a relatively high allele frequency. PMID:23652375

Huijts, Petra E A; Hollestelle, Antoinette; Balliu, Brunilda; Houwing-Duistermaat, Jeanine J; Meijers, Caro M; Blom, Jannet C; Ozturk, Bahar; Krol-Warmerdam, Elly M M; Wijnen, Juul; Berns, Els M J J; Martens, John W M; Seynaeve, Caroline; Kiemeney, Lambertus A; van der Heijden, Henricus F; Tollenaar, Rob A E M; Devilee, Peter; van Asperen, Christi J



Thermal unfolding studies show the disease causing F508del mutation in CFTR thermodynamically destabilizes nucleotide-binding domain 1  

PubMed Central

Misfolding and degradation of CFTR is the cause of disease in patients with the most prevalent CFTR mutation, an in-frame deletion of phenylalanine (F508del), located in the first nucleotide-binding domain of human CFTR (hNBD1). Studies of (F508del)CFTR cellular folding suggest that both intra- and inter-domain folding is impaired. (F508del)CFTR is a temperature-sensitive mutant, that is, lowering growth temperature, improves both export, and plasma membrane residence times. Yet, paradoxically, F508del does not alter the fold of isolated hNBD1 nor did it seem to perturb its unfolding transition in previous isothermal chemical denaturation studies. We therefore studied the in vitro thermal unfolding of matched hNBD1 constructs ±F508del to shed light on the defective folding mechanism and the basis for the thermal instability of (F508del)CFTR. Using primarily differential scanning calorimetry (DSC) and circular dichroism, we show for all hNBD1 pairs studied, that F508del lowers the unfolding transition temperature (Tm) by 6–7°C and that unfolding occurs via a kinetically-controlled, irreversible transition in isolated monomers. A thermal unfolding mechanism is derived from nonlinear least squares fitting of comprehensive DSC data sets. All data are consistent with a simple three-state thermal unfolding mechanism for hNBD1 ± F508del: N(±MgATP) ? IT(±MgATP) ? AT ? (AT)n. The equilibrium unfolding to intermediate, IT, is followed by the rate-determining, irreversible formation of a partially folded, aggregation-prone, monomeric state, AT, for which aggregation to (AT)n and further unfolding occur with no detectable heat change. Fitted parameters indicate that F508del thermodynamically destabilizes the native state, N, and accelerates the formation of AT.

Protasevich, Irina; Yang, Zhengrong; Wang, Chi; Atwell, Shane; Zhao, Xun; Emtage, Spencer; Wetmore, Diana; Hunt, John F; Brouillette, Christie G



The hOCT1 SNPs M420del and M408V alter imatinib uptake and M420del modifies clinical outcome in imatinib-treated chronic myeloid leukemia.  


Although the prognosis of chronic myeloid leukemia (CML) patients treated with imatinib is good, many fail to develop an optimal response or lose one. This heterogeneity could be attributed to the presence of human organic cation transporter-1 (hOCT1) single nucleotide polymorphisms (SNPs). In the present study, we analyzed the effect of 23 hOCT1 SNPs on imatinib treatment outcome in newly diagnosed CML patients using MassARRAY sequencing and pyrosequencing. The only SNP associated with outcome was M420del (rs35191146), with patients with the M420del demonstrating an increased probability of imatinib treatment failure. In CML cell lines transfected with M420del and/or M408V, M420del significantly decreased imatinib uptake, but this effect was countered if the M408V (rs628031) SNP was also present. A similar effect was seen for the uptake of the hOCT1 substrates TEA(+) and ASP(+). Finally, apparent hOCT1 mRNA levels were studied using both our earlier primers covering the M420del and another set that did not. Different mRNA expression was observed, explaining the disparity in published data on the prognostic importance of hOCT1 mRNA and highlighting the importance of avoiding common SNP sites in primer design. These data demonstrate that the common M420del SNP can modulate the outcome of imatinib treatment. PMID:23223357

Giannoudis, Athina; Wang, Lihui; Jorgensen, Andrea L; Xinarianos, George; Davies, Andrea; Pushpakom, Sudeep; Liloglou, Triantafilos; Zhang, Jieying-Eunice; Austin, Gemma; Holyoake, Tessa L; Foroni, Letizia; Kottaridis, Panagiotis D; Müller, Martin C; Pirmohamed, Munir; Clark, Richard E



Physiological profile of fighters influences training organisation in combat sports: response to Del Vecchio, Hirata, and Franchini (2011).  


The article by Del Vecchio, et al. (2011) provides relevant information to trainers about the effort-pause ratio during mixed martial arts matches. Taking into account the physiological profiles of fighters would increase interest in these findings. PMID:22403925

Paillard, Thierry



Association Between the NFKB1-94ins/del ATTG Polymorphism and Cancer Risk: An Updated Meta-Analysis.  


To assess the effect of the NFKB1 -94ins/del polymorphism on cancer, we conducted a meta-analysis based on 25 studies including 8,750 cases and 9,170 controls. Overall, the -94ins/del polymorphism was associated with cancer risk in the pooled analysis and in Asian population, whereas no association was observed in Caucasian population. Stratified analysis by subtypes of cancer showed that the -94ins/del polymorphism was associated with oral squamous cell carcinoma and ovarian cancer risk, but had no association with colorectal cancer, bladder cancer, and renal cell cancer. Our meta-analysis suggests the NFKB1 -94ins/del polymorphism affects cancer susceptibility, and the association is ethnic-specific. PMID:24827594

Duan, Wenyuan; Wang, Erli; Zhang, Fengquan; Wang, Tongjian; You, Xiangdong; Qiao, Bin



Los Alamos National Laboratory (USA): Instituto Mexicano Del Petroleo Cooperative Program for the ASPEN Flowsheet Simulator: Status Report.  

National Technical Information Service (NTIS)

On June 20, 1983, the Los Alamos National Laboratory, the US Department of Energy, and the Instituto Mexicano del Petroleo (IMP) signed a Memorandum of Understanding (MOU) that established a program of cooperation between the Los Alamos National Laborator...

T. T. Phillips



CHEK2 1100 delC mutation in Russian ovarian cancer patients.  


BRCA1 and BRCA2 germ-line mutations occur in a significant number of unselected ovarian cancer (OC) patients, thus making a noticeable contribution to OC morbidity. It is of interest whether CHEK2, which is frequently regarded as a third breast cancer specific gene, is also relevant to ovarian cancer pathogenesis. In this report we analyzed the presence of CHEK2 1100 delC founder mutation in 268 randomly recruited OC patients. The mutation was identified in 2 women with OC (0.8%) as compared to 1/448 (0.2%) healthy middle-aged and 0/373 elderly tumour-free women. Taken together this result and the negative findings of two other published reports on an association of CHEK2 with ovarian cancer indicate that there is no justification for intensive ovarian cancer screening in CHEK2 1100 delC carriers. PMID:19725991

Krylova, Nadezhda Yu; Ponomariova, Daria N; Sherina, Natalia Yu; Ogorodnikova, Natalia Yu; Logvinov, Denis A; Porhanova, Natalia V; Lobeiko, Oksana S; Urmancheyeva, Adel F; Maximov, Sergey Ya; Togo, Alexandr V; Suspitsin, Evgeny N; Imyanitov, Evgeny N



CHEK2 1100 delC mutation in Russian ovarian cancer patients  

PubMed Central

BRCA1 and BRCA2 germ-line mutations occur in a significant number of unselected ovarian cancer (OC) patients, thus making a noticeable contribution to OC morbidity. It is of interest whether CHEK2, which is frequently regarded as a third breast cancer specific gene, is also relevant to ovarian cancer pathogenesis. In this report we analyzed the presence of CHEK2 1100 delC founder mutation in 268 randomly recruited OC patients. The mutation was identified in 2 women with OC (0.8%) as compared to 1/448 (0.2%) healthy middle-aged and 0/373 elderly tumour-free women. Taken together this result and the negative findings of two other published reports on an association of CHEK2 with ovarian cancer indicate that there is no justification for intensive ovarian cancer screening in CHEK2 1100 delC carriers.

Krylova, Nadezhda Yu; Ponomariova, Daria N; Sherina, Natalia Yu; Ogorodnikova, Natalia Yu; Logvinov, Denis A; Porhanova, Natalia V; Lobeiko, Oksana S; Urmancheyeva, Adel F; Maximov, Sergey Ya; Togo, Alexandr V; Suspitsin, Evgeny N; Imyanitov, Evgeny N



Incentivos para atraer y retener personal de salud de zonas rurales del Per?: un estudio cualitativo  

PubMed Central

El objetivo fue identificar incentivos de atracción y retención en zonas rurales y distantes de Ayacucho, Perú. Fueron realizadas entrevistas en profundidad con 80 médicos, enfermeras, obstetras y técnicos (20 por grupo) de las zonas más pobres y con 11 funcionarios. No existen políticas sistemáticas de atracción y retención de personal de salud en Ayacucho. Los principales incentivos, en orden de importancia, fueron mejoras salariales, oportunidades de formación y capacitación, estabilidad laboral y nombramiento, mejoras en infraestructura y equipos, e incremento del personal. Se mencionaron también mejoras en la vivienda y alimentación, mayor cercanía con la familia y reconocimiento por el sistema de salud. Existen coincidencias y singularidades entre los distintos grupos sobre los incentivos clave para estimular el trabajo rural, que deben considerarse al diseñar políticas públicas. Las iniciativas del Estado deben comprender procesos rigurosos de monitoreo y evaluación, para asegurar que las mismas tengan el impacto deseado.

Huicho, Luis; Canseco, Francisco Diez; Lema, Claudia; Miranda, J. Jaime; Lescano, Andres G.



A Neandertal mandible from the Cova del Gegant (Sitges, Barcelona, Spain).  


A human mandible from the site of Cova del Gegant is described here for the first time and compared with other Middle and Upper Pleistocene representatives of the genus Homo from Europe and Southwest Asia. The specimen was recovered from sediments which also yielded Mousterian stone tools and Pleistocene fauna. The preserved morphology of the mandible, particularly in the region of the mental foramen, clearly aligns it with the Neandertals, making the Cova del Gegant the only known site in Catalonia documenting diagnostic human skeletal remains in association with Middle Paleolithic stone tools. This represents an important new addition to the human fossil record from the Iberian Peninsula and joins the Bañolas mandible in documenting the course of human evolution in the northern Mediterranean region of Spain. PMID:15896823

Daura, J; Sanz, M; Subirá, M E; Quam, R; Fullola, J M; Arsuaga, J L



Topological open string amplitudes on local toric del Pezzo surfaces via remodeling the B-model  

NASA Astrophysics Data System (ADS)

We study topological strings on local toric del Pezzo surfaces by a method called remodeling the B-model which was recently proposed by Bouchard, Klemm, Mariño and Pasquetti. For a large class of local toric del Pezzo surfaces we prove a functional formula of the Bergman kernel which is the basic constituent of the topological string amplitudes by the topological recursion relation of Eynard and Orantin. Because this formula is written as a functional of the period, we can obtain the topological string amplitudes at any point of the moduli space by a simple change of variables of the Picard-Fuchs equations for the period. By this formula and mirror symmetry we compute the A-model amplitudes on KF_2, and predict the open orbifold Gromov-Witten invariants of C/Z.

Manabe, Masahide



Datos sobre la biometría del Pájaro moscón (Remiz pendulinus) en la provincia de Alicante (SE de España)  

Microsoft Academic Search

Aquesta nota presenta dades biomètriques sobre la longitud de l'ala i el pes del teixidor en una localitat d'hivernada de la provincia d'Alacant. Es va obtenir una mitjana de la longitud de l'ala de 55,88 mm (SD= 1,85; n= 51), amb un rang de 51-60 mm. La mitjana del pes va ser 9,33 g (SD=0,52; n=51) (8-10,5). No es van

Ignacio García Peiró



Quaternary eruptive history and hazard-zone model at Nevado del Tolima and Cerro Machin volcanoes, Colombia  

Microsoft Academic Search

The ice-clad and fumarolic Nevado del Tourna volcano (4 ° 39?N, 75 ° 20?W) south of Nevado del Ruiz, is offset toward the southeast from the axis of the volcanic Ruiz-Tolima massif with respect to the major NE-trending strike-slip Palestina fault. It is composed of four units: (1) a pre-Tolima plateau-like basement of basaltic andesite lava flows of early Quaternary

J. C. Thouret; J. M. Cantagrel; C. Robin; A. Murcia; R. Salinas; H. Cepeda



Frequency of the CHEK2 1100delC Mutation among Women with Breast Cancer: An International Study  

Microsoft Academic Search

A founder allele in the CHEK2 gene (1100delC) has been associated with an elevated risk of breast cancer. This allele is responsible for the majority of CHEK2-associated breast cancers in women from northern European countries; however, within Europe, it seems to be rare in countries that are close to the Mediterranean. The frequency of the 1100delC allele has not been

Shiyu Zhang; Catherine M. Phelan; Phil Zhang; Francois Rousseau; Parviz Ghadirian; William Foulkes; Nancy Hamel; David McCready; Maureen Trudeau; Henry Lynch; Douglas Horsman; Zeba Aziz; Magda Gomes; Mauricio Magalhaes Costa; Alexander Liede; Aletta Poll; Ping Sun; Steven A. Narod



Microsoft Academic Search

Oggetto di questo lavoro è il perfezionamento di una tecnica interferometrica a luce laser E.S.P.I. per lo studio del comportamento a compressione di materiali quasi-fragili. Per lo sviluppo del sistema E.S.P.I. sono state effettuate prove di compressione su campioni prismatici in gasbeton, un particolare conglomerato aerato. Per misurare gli spostamenti verticali della superficie dei campioni, il setup E.S.P.I. è stato

Eva Coïsson; Daniele Ferretti



Microsoft Academic Search

Resumen. Este trabajo trata sobre el comportamiento mecánico del hormigón de alta resistencia cuando se ensa- ya a compresión y en control de deformación. Los ensayos se realizan a cuatro velocidades de deformación dife- rentes, en el rango de 1.5x10 -3 a 5.0x10 -8 s -1 . Los resultados obtenidos permiten cuantificar la ductilidad del ma- terial. Por ejemplo, la

G. Ruiz; J. R. Del Viso; J. R. Carmona



Aberrant RNA splicing in RHD 7-9 exons of DEL individuals in Taiwan: A mechanism study  

Microsoft Academic Search

BackgroundThe Rh blood D group provides a clinically important model of aberrant splicing with skipped exons. Approximately 30% of serologically D-negative Chinese individuals have an intact RHD gene (DEL phenotype) and induce allo-immunization in transfusions. The RHD1227GNA polymorphism occurs in >95% DEL phenotype of Asian descent. The effects of RHD 1227A and a novel allele on exon 9 splicing were

Hsiang-Chun Liu; Hock-Liew Eng; Yu-Fen Yang; Ya-Hui Wang; Kuan-Tsou Lin; Hua-Lin Wu; Tsun-Mei Lin



Spectroscopic Observation of Nova Del 2013 with the 2.6m Telescope of the Crimean Astrophysical Observatory  

NASA Astrophysics Data System (ADS)

We obtained low resolution spectra (R~1000) of Nova Del 2013 on August 15.8 UT using Nesmith spectrograph attached to the 2.6m telescope of the Crimean Astrophysical Observatory (Nauchny, Ukraine). The spectral observation were performed in the region 3470-7575 A. The spectra display that Nova Del 2013 is still in the fireball stage as mention Darnley et al. (ATEL 5279) and Shore et al. (ATEL 5282).

Tarasova, T. N.



Chemostratigraphy of the Lower Arroyo del Soldado Group (Vendian, Uruguay) and Palaeoclimatic Implications  

Microsoft Academic Search

New C- and O-isotopic determinations from the Vendian lower Arroyo del Soldado Group are reported and combined with sedimentologic and biostratigraphic data. On the basis of different geochemical and petrographic criteria, the primary nature of the C- and Sr-isotopic signature is shown. Positive d13C-values characterize the mainly siliciclastic upper Yerbal Formation, which contains oxide-facies BIF and a diverse assemblage of

Claudio Gaucher; Alcides Nóbrega Sial; Gonzalo Blanco; Peter Sprechmann



Disfrute del sol con cuidado -- Cualquier persona puede padecer cáncer de piel

Está bien pasar algún tiempo en el sol, pero usted debe saber que las personas de piel más oscura –incluso muchos hispanos o latinos– tienen riesgo de padecer cáncer de piel. Siempre que pueda, evite exponerse al sol, especialmente entre las 10 a.m. y las 4 p.m., cuando los rayos del sol son más fuertes. Si trabaja o juega al aire libre, cúbrase y protéjase la piel con prendas de vestir, sombreros, lentes, filtros solares.


Physical, morphological and chemical characteristics, oil recovery and fatty acid composition of Balanites aegyptiaca Del. kernels  

Microsoft Academic Search

Balanites aegyptiaca Del. kernels were chemically,physically and morphologically characterized. Crude oil (49.0%) andcrude protein (32.4%) were the two major constituents of the kernels.Phytic acid content was relatively high compared to other legumes. Incontrast, antitryptic activities of the kernel flours were very low.Sapogenin contents of the full fat, defatted and testa flours were 1.5, 2.7and 3.0%, respectively. The hardness of the

A. M. Mohamed; W. Wolf; W. E. L. Spieß



Observación y registro fotográfico del cometa HYAKUTAKE C/1996 B2  

NASA Astrophysics Data System (ADS)

Desde el momento en que nos llega la información del descubrimiento, comenzamos la observación de forma detallada a fin de apreciar y seguir su creciente actividad. La primera observación se realizó el 17 de febrero de 1996 a las 4h20m UT con nuestro telescopio de 300mm newtoniano de f/6.5, con una muy buena transparencia atmosférica, estimando una magnitud de 8.5. Realizábamos observaciones casi todas las noches, mientras nos lo permitían las condiciones climáticas. Ya el 26 de febrero el cometa presentaba un aspecto muy particular, ligeramente distinto a las primeras observaciones, ya que comenzamos a notar su gran actividad. En primer lugar se destacaba la cola de iones mucho mas extensa que la cola de polvo. Magnitud estimada 7.5. El 19 de marzo ya era visible a simple vista y en especial su cola muy abierta y extensa (3 grados) y no quedaba duda alguna que la última noche de observación del cometa en el horizonte de la Ciudad de Funes, que fue el 24 de marzo de 1996, un día antes del acercamiento a la Tierra, tendríamos una apreciación del cometa en su máximo esplendor. El 24 de marzo de 1996 a las 4hs UT, asomó el cometa por el horizonte NE, con su cola espectacular, llegando a medir 23 grados de longitud, muy recta y brillante, y su cabellera muy estelar. A este marco de observación se sumaron mas de 600 personas que participaron usando instrumentos, siendo la mayoría de los concurrentes de la vecina Ciudad de Rosario, ya que su observación era a muy baja atura sobre el horizonte norte. Instrumentos utilizados : Telescopio Newtoniano 300mm f/6.5, Telescopio Schmidt-Cassegrain 200mm , Binoculares 10 x 50, 7 x 50, Lente normal 50mm a f/1.8, Película 100 - 400 ASA Lugar de Observación : Ciudad de Funes, zona rural, ``Estancia La Polola" Latitud: - 32o 55' Longitud: 60o 40' Oeste

Arquiola, A. P.; Arquiola, F. E.


Brand extension nelle imprese di servizi sportivi: opportunità ed implicazioni manageriali nel caso del calcio  

Microsoft Academic Search

L’obiettivo del lavoro è di definire le opportunità e le implicazioni manageriali connaturate all’implementazione di strategie di sfruttamento dei brand all’interno delle imprese di servizi sportivi. L’interesse nei confronti delle strategie di brand discende da un lato dalla necessità per le imprese sportive di diversificare le proprie attività e di svincolare le performance economiche dai risultati sul campo e, dall’altro,

Tommasina Pianese



Life to 450 m depth at Isla del Coco, Costa Rica  

Microsoft Academic Search

Isla del Coco is the summit of a seamount 500 km southwest of Costa Rica's mainland. The island is surrounded by a platform about 18 km long that trends in a southwest-northeast direction with a break in slope at around 180 m deep. Since 2006 the DeepSee submarine, with a 450 m depth capability, has been exploring the deep-water environments

Jorge Cortés; Shmulik Blum


Evaluacion de proceso del programa de educacion afectivo-sexual Ni ogros ni princesas.  


RESUMEN Fundamento: En 2008, se puso en marcha el programa Ni ogros ni princesas en 12 centros de secundaria de Asturias (España) para incorporar la educación afectivo-sexual. El programa proponía 14 actividades, dirigidas a alumnado, profesorado y familias. Este estudio recoge la evaluación de proceso de esta intervención, en relación a la ejecución de las actividades, participación, satisfacción, utilidad percibida y propuestas de mejora. Métodos: La población de estudio fueron los 12 centros que participaron en el programa, y su alumnado, profesorado y familias. Se obtuvo información sobre la ejecución de actividades mediante un cuestionario de seguimiento; se recogió la satisfacción y utilidad percibida con cuestionarios auto-administrados para alumnado y profesorado; también se recogieron sus propuestas de mejora, y las de las familias, en grupos focales. Resultados: El número medio de actividades realizadas por los 12 centros fue 11,6. Se implicaron 185 docentes (26%), que impartieron sesiones al 81% del alumnado en estos 12 centros. El número medio de sesiones impartidas fue 6 en cada nivel de la ESO. El 79% del profesorado se sintió bastante/muy satisfecho con su actuación y al 65% del alumnado le gustaron bastante/mucho estas sesiones. Más del 60% de estudiantes y docentes consideraron que estas sesiones servían bastante/mucho para aumentar conocimientos, reflexionar, mejorar la igualdad, conocer otras opiniones y favorecer el respeto a la diversidad sexual. Entre las propuestas de mejora, más horas para la educación sexual, liberación horaria para el profesorado, y más actividades para familias. Conclusiones: El programa fue una intervención novedosa y percibida como útil para incorporar la educación sexual en los centros de secundaria, ya que contó con un gran nivel de ejecución, así como una alta participación, satisfacción y utilidad percibida por el alumnado y profesorado. PMID:24801790

García-Vázquez, Jose; Ordóñez, Adelina Lena; Alvarez, Y Óscar Suárez



GIS based Relative Tsunami Hazard Maps for Northern California, Humboldt and Del Norte Counties  

Microsoft Academic Search

Tsunami hazard maps are generated using a geographical information systems (GIS) approach to depict the relative tsunami hazard of coastal Humboldt and Del Norte Counties in northern California. Maps are composed for the Humboldt Bay, Eel River, and Crescent City regions and available online at http:\\/\\/\\/~geodept\\/earthquakes\\/rctwg\\/toc.html . In contrast to previous mapping efforts that utilize a single line to represent

J. R. Patton; L. A. Dengler



Isolation and assessment of phytate-hydrolysing bacteria from the DelMarVa Peninsula  

Microsoft Academic Search

Summary The Delaware-Maryland-Virginia (DelMarVa) Penin- sula, flanking one side of the Chesapeake Bay, is home to a substantial broiler chicken industry. As such, it produces a significant amount of manure that is typically composted and spread onto local crop- lands as a fertilizer. Phytate (myo inositol hexak- isphosphate), the major form of organic phosphorus in the manure, can be hydrolysed

Jane E. Hill; David Kysela; Menachem Elimelech



Disfrute del sol con cuidado -- Cualquier persona puede padecer cáncer de piel

Está bien pasar algún tiempo al aire libre, pero usted debe saber que las personas de piel más oscura –incluso muchos hispanos o latinos– tienen riesgo de padecer cáncer de piel. Siempre que pueda, evite exponerse al sol, especialmente entre las 10 a.m. y las 4 p.m., cuando los rayos del sol son más fuertes. Si trabaja o juega al aire libre, cúbrase y protéjase la piel con prendas de vestir, sombreros, lentes, filtros solares.


Estudio semiótico de El embrujado de Ramón del Valle-Inclán  

Microsoft Academic Search

El embrujado by Ramón del Valle-Inclán, published first in 1913, did not enjoy a positive reception from the public and the critics. The play was not actually produced\\u000a on stage until 1931 by the Teatro Muñoz Seca. Even though critical reception was a bit more positive this time, the play did\\u000a not achieve great public success. This essay constitutes a

Inma Cívico Lyons



Optimización mediante algoritmos genéticos de la gestión del agua en el regadío  

Microsoft Academic Search

El uso de un recurso como el agua, esencial y escaso, tiene gran trascendencia ambiental, social, económica,\\u000apolítica, etc., siendo su adecuada gestión fundamental para conseguir la sostenibilidad de sus aprovechamientos.\\u000aPara alcanzar ese objetivo, la agricultura actual necesita modelos de ayuda a la toma de decisiones para\\u000ala gestión y explotación agrícola.\\u000aSe presenta un modelo de optimización del

Pedro Carrión; Eulogio López; José Fernando Ortega; Arturo de Juan



An Accretion Disc Model For Algol Type Eclipsing Binary System: AV Del  

Microsoft Academic Search

We inspect the light and radial-velocity curves of the eclipsing binary AV\\u000aDel. Using the most new version of Wilson - Devinney (1971) code (for more\\u000ainformation please see Wilson - Wan Hamme, 2003), the absolute elements,\\u000afundamental orbital and physical parameters of the system are determined. Using\\u000athese parameters the configuration of the system are presented. Then, using the

Sayyed Mohammad Reza Ghoreyshi; Jamshid Ghanbari; Fatemeh Salehi



Antimicrobial activity of flavonoids in medicinal plants from Tafí del Valle (Tucumán, Argentina).  


Preliminary studies of flavonoids have been realised in five native species from Tafí del Valle (Tucumán, Argentina) used in popular medicine. Most of compounds detected were flavonoids mono and dihydroxylated in B ring. Screening for antimicrobial activity against Gram positive and Gram negative microorganisms has been realised with Lippia turbinata, Satureja parvifolia, Sambucus peruviana, Verbena officinalis and Chenopodium graveolens. The total extracts of flavonoids of each plant were tested and four species studied showed antimicrobial activity. PMID:11025172

Hernández, N E; Tereschuk, M L; Abdala, L R



Análisis geométrico de localización del modelo elastoplástico parabólico de Drucker-Prager dependiente de gradientes  

Microsoft Academic Search

En este trabajo se presenta el método geométrico para el análisis de las propiedades de localización del modelo\\u000aelastoplástico parabólico de Drucker-Prager dependiente de gradientes. El modelo es termodinámicamente\\u000aconsistente. A partir de la solución de la condición de bifurcación discontinua de la elastoplasticidad dependiente\\u000ade gradientes para pequeñas deformaciones, se formula la elipse de localización en las coordenadas\\u000ade

Sonia Mariel Vrech; Guillermo Etse



Red de Investigación del Cáncer de los Estados Unidos y América Latina

El estado general de la infraestructura de capacidad y apoyo de la investigación y desarrollo tanto de investigación como del ejercicio de la atención médica es bastante diversa en América Latina. Algunos países latinoamericanos con diferentes niveles capacidad de investigación y de ejercicio de la atención médica se han unido a la Oficina para el Desarrollo de Programas de Cáncer en América Latina para formar la Red de Investigación de Cáncer de los Estados Unidos y América Latina.


Experience the magic of light and color: outreach activity by Universidad del Valle student chapter  

NASA Astrophysics Data System (ADS)

During 2007, the Universidad del Valle Student Chapter presented a proposal for developing an educational outreach activity for children from an underprivileged zone to the Optical Society of America Foundation (OSAF) and to SPIE. The activity was carried out jointly by OSA and SPIE Universidad del Valle Student Chapters in the hillsides of Santiago de Cali, in a zone known as "Pueblo Joven" during 2008. It was aimed to boys and girls with ages between 8 and 13 years and was called "Experience the magic of light and color". The main purpose was to bring the children some basic concepts on optics and to encourage them to explore science through optics. The Universidad del Valle Student Chapters designed a series of talks and practical workshops where children participated in hands-on experiments that easily explain the fundamental concepts of light phenomena. Afterwards the children presented their achievements in a small science fair offered to the community and tried to explain in their own words what they learned and built. In this work, we present the most successful experimental designs and the educational standards we tried to develop with this activity.

Valdes, Claudia; Reyes, Camilo; Osorio, Alberto; Solarte, Efrain



[Seventy years of medicine in the Instituto Mexicano del Seguro Social].  


The purpose of these lines is to remember and refer some of the historical landmarks in the evolution of the medical services of the Instituto Mexicano del Seguro Social (IMSS, according to its initials in Spanish) since it was founded, in 1943. We also want to bring to the reader's attention that the dimensions and impacts on health that IMSS has achieved, throughout its history, have strengthened the citizenship, as well as social sustainability. Also, those impacts have determined the creation and the reinforcement of human capital in México. Throughout this concise balance, all the controversy surrounding the foundation of the Institute is being recalled (the protest in the Mexico City Zócalo, or the attack to an hospital in San Ángel -a neighborhood located in the Southwest of Mexico City-), as well as the way the IMSS incorporated several words into the vocabulary of Mexicans. We also remember the previous antecedent of the Revista Médica del Instituto Mexicano del Seguro Social, as well as the Revista de Enfermería, and the emblematic Archives of Medical Research. The IMSS has 70 years of achievements, seven decades covered. PMID:24758865

Fajardo-Ortiz, Guillermo



A Precambrian cratonic block in the west-central Chihuahua - The Sierra del Nido cratonic block  

SciTech Connect

Precambrian rocks in west-central Chihuahua have been recognized by Denison (1969) and Mauger et al. (1983), on the basis of radiometric dating. The rocks are rhyolite clasts, and an allucthonous block, respectively, however their source direction and vergence can be measured. They point back to and are on the edge of a large, uniform, negative Bouguer gravity anomaly, having values greater than 200 milligals. The isotopic geochemical character of several Tertiary felsic fields within this anomalous are has been determined, and initial strontium isotopic ratios are all greater than 0.7055. Outside the anomalous area these ratios are lower, and Basin and Range extension tectonism is more evident. It is proposed that a Precambrian cratonic block, the Sierra del Nido, is present in the crust in west-central Chihuahua. It is reasonable to propose that it was decreted from North America during a Precambrian extensional (1.1. By ) event, from somewhere along the Arizona Transition Zone-Texas Linament region. The Sierra del Nido Block is separated form the ATZ-TL by a region of disrupted craton and extended crust, the Basin and Range Province. Implications of the pressure of the Sierra del Nido Block on other regional tectonic events will be discussed.

Goodell, P.C. (Univ. of Texas, El Paso, TX (United States). Dept. of Geological)



Variation in mangrove forest structure and sediment characteristics in Bocas del Toro, Panama  

USGS Publications Warehouse

Mangrove forest structure and sediment characteristics were examined in the extensive mangroves of Bocas del Toro, Republic of Panama. Forest structure was characterized to determine if spatial vegetation patterns were repeated over the Bocas del Toro landscape. Using a series of permanent plots and transects we found that the forests of Bocas del Toro were dominated by Rhizophora mangle with very few individuals of Avicennia germinans and Laguncularia racemosa. Despite this low species diversity, there was large variation in forest structure and in edaphic conditions (salinity, concentration of available phosphorus, Eh and sulphide concentration). Aboveground biomass varied 20-fold, from 6.8 Mg ha-1 in dwarf forests to 194.3 Mg ha-1 in the forests fringing the land. But variation in forest structure was predictable across the intertidal zone. There was a strong tree height gradient from seaward fringe (mean tree height 3.9 m), decreasing in stature in the interior dwarf forests (mean tree height 0.7 m), and increasing in stature in forests adjacent to the terrestrial forest (mean tree height 4.1 m). The predictable variation in forest structure emerges due to the complex interactions among edaphic and plant factors. Identifying predictable patterns in forest structure will aid in scaling up the ecosystem services provided by mangrove forests in coastal landscapes. Copyright 2005 College of Arts and Sciences.

Lovelock, C. E.; Feller, I. C.; McKee, K. L.; Thompson, R.



Identification of synergistic combinations of F508del cystic fibrosis transmembrane conductance regulator (CFTR) modulators.  


Cystic fibrosis (CF) is an inherited, life-threatening disease caused by mutations in the gene encoding cystic fibrosis transmembrane conductance regulator (CFTR), an ABC transporter-class protein and ion channel that transports ions across epithelial cell membranes. The most common mutation leads to the deletion of a single phenylalanine, and the resulting protein, F508del-CFTR, shows reduced trafficking to the membrane and defective channel gating. The ideal therapeutic approach would address both of these defects and restore channel function at the same time. We describe here the application of a combination high-throughput screening to search for synergistic modulators of F508del-CFTR. With the adapted Fischer rat thyroid-yellow fluorescent protein halide flux assay to the combination high-throughput screening platform, we identified many interesting single agents as CFTR modulators from a library of approved drugs and mechanistic probe compounds, and combinations that synergistically modulate F508del-CFTR channel function in Fischer rat thyroid cells, demonstrating the potential for combination therapeutics to address the defects that cause CF. PMID:21050065

Lin, Stephen; Sui, Jinliang; Cotard, Shakira; Fung, Brenda; Andersen, Jennifer; Zhu, Ping; El Messadi, Najib; Lehar, Joseph; Lee, Margaret; Staunton, Jane



Pampa del Palo: an anomalous composite marine terrace on the uprising coast of southern Peru  

NASA Astrophysics Data System (ADS)

Quaternary sediments along the southern Perúvian coast occur as staircase terraces of coastal and shallow-marine deposits in response to continuous uplift related to the active boundary between the Nazca and South-American plates. However, near ILO (in the same coastal stretch) the emergent Pampa del Palo terrace consists of a relatively-thick, vertical stack of shallow-marine, coastal and lagoonal deposits that indicate a rather different geodynamic behaviour. Coastal deposits are correlatable with the successive marine highstands of isotopic stages 7 (?) and 5 (substages 5e and 5c). Combining aerial photo-interpretation, geomorphological mapping, sedimentological analysis, chronostratigraphical data, and structural observations, the Pampa del Palo feature is interpreted as a faulted block that moved independently of the remaining southern Peruvian coast and, for some time between the end of Middle Pleistocene (before ca. 220 ka) and the early Late Pleistocene (ca. 120 ka), it rose more slowly or was even down-faulted relative to the rest of the southern Peruvian margin. The independent block movements ceased after substage 5e, when the Pampa del Palo "terrace" was incorporated into the regional uplift of the area. Since ca. 100 ka, measured uplift rates in the Ilo area amounted up to {160 mm}/{10 3y } when the area has been affected by a few active, NE-SE trending faults only.

Ortlieb, L.; Zazo, C.; Goy, J. L.; Dabrio, C.; Macharé, J.



DLX3 c.561_562delCT mutation causes attenuated phenotype of tricho-dento-osseous syndrome.  


The distal-less homeobox gene DLX3 is expressed in a variety of tissues including placenta, skin, hair, teeth, and bone. Mutation of DLX3 (c.571_574delGGGG) causes the tricho-dento-osseous syndrome (TDO), characterized by abnormal hair, teeth, and bone. Evaluation of a kindred segregating the DLX3 c.561_562delCT mutation revealed distinct changes in the hair, teeth, and bones as has been observed with the DLX3 c.571_574delGGGG mutation. Previously, the DLX3 c.561_562delCT mutation was associated with autosomal dominant amelogenesis imperfecta with taurodontism. The present study shows that the DLX3 c.560_561delCT mutation causes an attenuated TDO phenotype with less severe hair, tooth, and bone manifestations compared with individuals having the DLX3 c.571_574delGGGG mutation. Careful phenotyping of individuals with allelic DLX3 mutations reveals marked differences in phenotypic severity indicating that the carboxy-terminus of the DLX3 protein is critical in determining its function during development in these different tissues. PMID:18203197

Wright, J Timothy; Hong, Sung P; Simmons, Darrin; Daly, Bill; Uebelhart, Daniel; Luder, Hans U



Association between NFKB1 -94ins/del ATTG Promoter Polymorphism and Cancer Susceptibility: An Updated Meta-Analysis  

PubMed Central

Nuclear factor-?B is associated with the pathogenesis of numerous malignancies, and the functional polymorphism ?94ins/del ATTG (rs28362491) in the human NFKB1 gene is associated with cancer risk. Previous studies on the association between the ?94ins/del ATTG polymorphism and cancer risk reported conflicting results. To clarify this relationship, we performed a meta-analysis of 21 case-control studies involving 6127 cases and 9238 controls. We used pooled odds ratios (ORs) with their 95% confidence intervals (95% CIs) to assess the association. We found that the NFKB1 promoter ?94ins/del ATTG polymorphism was significantly associated with cancer risk in four genetic models (ins/ins versus del/del, OR = 1.47, 95% CI = 1.11–1.93; dominant model, OR = 1.26, 95% CI = 1.03–1.53; recessive model, OR = 1.26, 95% CI = 1.05–1.51; ins allele versus del allele, OR = 1.19, 95% CI = 1.05–1.35). Stratified analyses revealed a significant association between the polymorphism and ovarian, oral, and prostate cancers. Similar results were determined in an Asian population and not in a Caucasian population. Thus, our results suggested that the polymorphism can contribute to cancer risk. Moreover, the polymorphism can exert race- and cancer-specific effects on cancer risk. Further large-scale and functional studies are necessary to elucidate this possible effect.

Tao, Jun; Cao, Qiang; Gu, Jinbao; Deng, Xiaheng; Wang, Jun; Liu, Xuzhong; Wang, Zijie; Wu, Bian; Lu, Qiang; Yin, Changjun



Virus-like attachment sites and plastic CpG islands:landmarks of diversity in plant Del retrotransposons.  


Full-length Del elements from ten angiosperm genomes, 5 monocot and 5 dicot, were retrieved and putative attachment (att) sites were identified. In the 2432 Del elements, two types of U5 att sites and a single conserved type of U3 att site were identified. Retroviral att sites confer specificity to the integration process, different att sites types therefore implies lineage specificity. While some features are common to all Del elements, CpG island patterns within the LTRs were particular to lineage specific clusters. All eudicot copies grouped into one single clade while the monocots harbour a more diverse collection of elements. Furthermore, full-length Del elements and truncated copies were unevenly distributed amongst chromosomes. Elements of Del lineage are organized in plants into three clusters and each cluster is composed of elements with distinct LTR features. Our results suggest that the Del lineage efficiently amplified in the monocots and that one branch is probably a newly emerging sub-lineage. Finally, sequences in all groups are under purifying selection. These results show the LTR region is dynamic and important in the evolution of LTR-retrotransposons, we speculate that it is a trigger for retrotransposon diversification. PMID:24849372

Cruz, Guilherme M Q; Metcalfe, Cushla J; de Setta, Nathalia; Cruz, Edgar A O; Vieira, Andréia Prata; Medina, Rosario; Van Sluys, Marie-Anne



Virus-Like Attachment Sites and Plastic CpG Islands: Landmarks of Diversity in Plant Del Retrotransposons  

PubMed Central

Full-length Del elements from ten angiosperm genomes, 5 monocot and 5 dicot, were retrieved and putative attachment (att) sites were identified. In the 2432 Del elements, two types of U5 att sites and a single conserved type of U3 att site were identified. Retroviral att sites confer specificity to the integration process, different att sites types therefore implies lineage specificity. While some features are common to all Del elements, CpG island patterns within the LTRs were particular to lineage specific clusters. All eudicot copies grouped into one single clade while the monocots harbour a more diverse collection of elements. Furthermore, full-length Del elements and truncated copies were unevenly distributed amongst chromosomes. Elements of Del lineage are organized in plants into three clusters and each cluster is composed of elements with distinct LTR features. Our results suggest that the Del lineage efficiently amplified in the monocots and that one branch is probably a newly emerging sub-lineage. Finally, sequences in all groups are under purifying selection. These results show the LTR region is dynamic and important in the evolution of LTR-retrotransposons, we speculate that it is a trigger for retrotransposon diversification.

de Setta, Nathalia; Cruz, Edgar A. O.; Vieira, Andreia Prata; Medina, Rosario; Van Sluys, Marie-Anne



Comparison of the free radical-scavenging activity of propolis from several regions of Argentina.  


Propolis is extensively used in Argentine folk medicine. Alcoholic extracts of propolis from different regions of Argentina were prepared. The extracts were analysed for the determination of total flavonoid content (from 13.3 to 42.6 mg/g of propolis) by using the aluminum nitrate method, UV spectrophotometry and thin layer chromatography. All of them contained high total flavonoid content. It was also observed that all samples of ethanolic extracts of propolis showed free radical-scavenging activity in terms of scavenging of the radical DPPH but the highest activities were found for samples from Tucumán and Santiago del Estero. In all cases with 20 microg/ml of soluble principles, the percentage of DPPH degradation was different (Banda Oeste: 67.5%; Verónica: 45%; Forres: 35%; Saenz Peña: 20% and Juan José Castelli: 55%). These results may justify their use as a source of natural antioxidants. PMID:10904153

Moreno, M I; Isla, M I; Sampietro, A R; Vattuone, M A



Variability in photobleaching yields and their related impacts on optical conditions in subtropical lakes.  


Changes in the concentration and spectral absorption of chromophoric dissolved organic matter (CDOM) may strongly condition the optical properties of tropical and subtropical water bodies. We examined the spatial distribution of CDOM-related absorption, spectral slope and vertical attenuation of solar radiation in two shallow lakes in the Esteros del Iberá wetland system. In situ measurements were made to examine spatial variations in photobleaching yields in natural lake conditions. The results showed that "fresh" allochthonous CDOM is more susceptible to phototransformations than either "aged" allochthonous organic matter or autochthonous sources, if the distances from sources are considered as proxies for residence time. Based on measured changes in absorption spectral slope in relation to solar ultraviolet irradiance, a model was developed which used CDOM as a non-conservative tracer of water masses. Spatial changes in CDOM absorption within the lake were then used to compare photo related transformations to those associated with conservative mixing. PMID:19303317

Loiselle, Steven A; Bracchini, Luca; Cózar, Andres; Dattilo, Arduino M; Tognazzi, Antonio; Rossi, Claudio



[Effect of the populations of Alabama argillacea (Hübner) (Lepidoptera: Noctuidae) on cotton crop at two sowing distances].  


The objective of this research was to evaluate the incidence of damage by the leafworm Alabama argillacea (Hübner) on yields of cotton grown under rows spaced 0.38 m and 0.76 m at the irrigation area of Santiago del Estero, Argentina. The period evaluated was extended from first flower to first open boll. Treatments were T1 - without control of larvae, T2 - with control of larvae, T3 - control since first flower to the end of effective blooming, and T4 - with larval control since the end of effective blooming to first open boll. The effect of injuries on the crop was evaluated trough boll cotton yield. Larvae were sampled in a weekly basis and insects were present from the first flower until harvest. Populations of A. argillacea decreased crop yields in the two distances tested, by decreasing the weight or number of open bolls. PMID:21584408

Helman, S A; Beltran, R E; Garay, F; Raña, E



Insects found in birds' nests from Argentina: Coryphistera alaudina Burmeister, 1860 (Aves: Furnariidae), their inquiline birds and mammals, new hosts for Psammolestes coreodes Bergroth, 1911 and Triatoma platensis Neiva, 1913 (Hemiptera: Reduviidae: Triatominae).  


The insect fauna in nests of Coryphistera alaudina Burmeister, 1860 (Aves: Furnariidae) were studied in the provinces of Santiago del Estero, Chaco, Córdoba, and La Pampa in Argentina. A total of 7364 insect specimens comprising 77 taxa in a total of 29 families and 7 orders was found in their nests: 40 identified to species, 23 identified to genus, and 14 identified to family. Coryphistera alaudina and some of their vertebrate inquilines are new host records for the triatomine bugs Psammolestes coreodes Bergroth, 1911 and/or Triatoma platensis Neiva, 1913 (Hemiptera: Reduviidae). The insects in the nests of C. alaudina are separated by functional guilds, and their permanence time inside the nests are presented in a new manner and discussed. PMID:24943157

Turienzo, Paola; Di Iorio, Osvaldo



Prevalence of the BRCA1 c.68_69delAG (BIC: 185delAG) mutation in women with breast cancer from north-central Poland and a review of the literature on other regions of the country  

PubMed Central

Aim of the study Germline mutations in BRCA tumor suppressor genes are strongly associated with breast and ovarian cancer. The lifetime risk of these cancers in women with BRCA1 mutation is 84% and 27%, respectively. Studies on the prevalence of BRCA1 c.68_69delAG congenital mutation, the most frequent in Ashkenazi Jews, among women with breast cancer from north-central Poland and review of the literature on other regions of the country. Evaluation of the c.68_69delAG association with breast cancer risk, with respect to women's age at diagnosis and family history of cancer. Material and methods 252 women with breast cancer, without any of the mutations c.5266dupC, c.181T > G, or c.4034delA, regardless of histological type and family history of cancer. The mutation was detected using allele-specific oligonucleotide polymerase chain reaction (ASO-PCR) assay and confirmed by sequence analysis. Results The c.68_69delAG mutation was disclosed in one out of the 252 women (0.4%), who had been diagnosed with breast cancer at age 43. Family investigations revealed the presence of c.68_69delAG also in the patient's mother, diagnosed with breast cancer at age 68. Sequence analysis confirmed the heterozygous status of the mutation, and family investigation its hereditary character. In the group of families with breast cancer history 1.4% frequency of c.68_69delAG was shown. Conclusions Among families with breast cancer aggregation, originating from north-central Poland, c.68_69delAG is a rare BRCA1 alteration, similarly to other central regions of the country, investigated by other authors. However, in northern, north-western and south-western parts of Poland, it occurs 2–4 times more frequently than in our region.

Janiszewska, Hanna; Bak, Aneta; Pilarska, Maria; Heise, Marta; Junkiert-Czarnecka, Anna; Laskowski, Ryszard; Haus, Olga



Rescue of Murine F508del CFTR Activity in Native Intestine by Low Temperature and Proteasome Inhibitors  

PubMed Central

Most patients with Cystic Fibrosis (CF) carry at least one allele with the F508del mutation, resulting in a CFTR chloride channel protein with a processing, gating and stability defect, but with substantial residual activity when correctly sorted to the apical membranes of epithelial cells. New therapies are therefore aimed at improving the folding and trafficking of F508del CFTR, (CFTR correctors) or at enhancing the open probability of the CFTR chloride channel (CFTR potentiators). Preventing premature breakdown of F508del CFTR is an alternative or additional strategy, which is investigated in this study. We established an ex vivo assay for murine F508del CFTR rescue in native intestinal epithelium that can be used as a pre-clinical test for candidate therapeutics. Overnight incubation of muscle stripped ileum in modified William's E medium at low temperature (26°C), and 4 h or 6 h incubation at 37°C with different proteasome inhibitors (PI: ALLN, MG-132, epoxomicin, PS341/bortezomib) resulted in fifty to hundred percent respectively of the wild type CFTR mediated chloride secretion (forskolin induced short-circuit current). The functional rescue was accompanied by enhanced expression of the murine F508del CFTR protein at the apical surface of intestinal crypts and a gain in the amount of complex-glycosylated CFTR (band C) up to 20% of WT levels. Sustained rescue in the presence of brefeldin A shows the involvement of a post-Golgi compartment in murine F508del CFTR degradation, as was shown earlier for its human counterpart. Our data show that proteasome inhibitors are promising candidate compounds for improving rescue of human F508del CFTR function, in combination with available correctors and potentiators.

Wilke, Martina; Bot, Alice; Jorna, Huub; Scholte, Bob J.; de Jonge, Hugo R.



Art pop i curtmetratges a una biblioteca penitenciària: tallers de dinamització cultural a la Biblioteca del Centre Penitenciari de Joves de Barcelona  

Microsoft Academic Search

Es descriuen i s'analitzen dues activitats d'extensió cultural dutes a terme a la Biblioteca del Centre Penitenciari de Joves de Barcelona a partir d'una col·laboració externa. S'inclou una descripció del Centre, de la Biblioteca i del perfil d'usuari a qui s'han dirigit les activats. Seguidament, es resumeixen els diferents passos duts a terme per a la confecció de les activitats,

Laia Castell Padilla; Josep M. Pallisé Carreté; Núria Pedrola i Guillén; Cristina Tomàs i Humbert; Lola Burgos Oliván



The Torres del Paine intrusion as a model for a shallow magma chamber  

NASA Astrophysics Data System (ADS)

The shallow magmatic Torres del Paine Intrusive Complex (TPIC) belongs to a series of sub-volcanic and plutonic igneous bodies in Southern Chile and Argentina. This trench-parallel belt is located in a transitional position between the Patagonia Batholith in the West, and the alkaline Cenozoic plateau lavas in the East. While volumetrically small amounts of magmatism started around 28 my ago in the Torres del Paine area, and a second period occurred between 17-16 Ma, it peaked with the TPIC 12.59-12.43 Ma ago. The spectacular cliffs of the Torres del Paine National park provide a unique opportunity to study the evolution of a very shallow magma chamber and the interaction with its host rocks. Intrusion depth can be estimated based on contact metamorphic assemblages and granite solidus thermobarometry to 750±250 bars, corresponding to an intrusion depth of ca. 3km, ca. 500m above the base of the intrusion. Hornblende thermobarometry in mafic rocks agrees well with these estimates (Leuthold et al., 2014). The TPIC is composed of a granitic laccolith emplaced over 90ka (Michel et al., 2008) in 3 major, several 100m thick sheets, forming an overall thickness of nearly 2 km. Contacts are sharp between sheets, with the oldest sheet on the top and the youngest on the bottom (Michel et al., 2008). The granitic laccolith is under-plated by a ca. 400m thick mafic laccolith, built up over ca. 50ka (Leuthold et al. 2012), constructed from the bottom up. Granitic and mafic sheets are themselves composed of multiple metric to decametric pulses, mostly with ductile contacts between them, resulting in outcrop patterns resembling braided stream sediments. The contact of the TPIC with the Cretaceous flysch sediments document intrusion mechanism. Pre-existing sub-horizontal fold axes are rotated in the roof of the TPIC, clearly demonstrating ballooning of the roof; no ballooning was observed in the footwall of the intrusion. Extension during ballooning of the roof is indicated by dykes emanating from the roof of the intrusion into the host rocks. The dykes are perpendicular to the contact, radially shooting into the country rocks. Since the oldest granite is found in the roof, it is also permeated by dykes of successive intrusions. Contact metamorphism can be used to constrain the granite intrusion temperature to ca. 1000°C. Intrusion occurred in multiple pulses along the granite-host rock contact, in rapid succession, before significant cooling occurred in the aureole. Hydration of the biotite and feldspar of the immature sediments in the outer aureole contributed significantly to the overall thermal signature of the host-rock-TPIC system. In contrast, stable isotopes do not document significant fluid circulation. Leuthold, J., Müntener, O., Baumgartner, L., Putlitz, B., Ovtcharova, M., Schaltegger, U. (2012) Time resolved construction of a granitic to mafic laccolith (Torres del Paine, Patagonia). Earth Plan Sci Lett. 325. 85-92 Leuthold J., Müntener O., Baumgartner L.P., Putlitz B., (2014) Recycling of mafic crystal mush, transport and emplacement in the Torres del Paine mafic complex (Patagonia). J. Petrology; accepted pending revision Michel, J., Baumgartner, L.P. Putlitz, B., Ovtcharova, M., Schaltegger, U. (2008) Incremental growth of a shallow crustal laccolith over 80 kyrs: the Torres del Paine Granite, Patagonia. Geology vol. 36, 459-462

Baumgartner, Lukas; Bodner, Robert; Leuthold, Julien; Muntener, Othmar; Putlitz, Benita; Vennemann, Torsten



Oxygen isotope evidence for submarine hydrothermal alteration of the Del Puerto ophiolite, California  

USGS Publications Warehouse

The oxygen isotope compositions and metamorphic mineral assemblages of hydrothermally altered rocks from the Del Puerto ophiolite and overlying volcaniclastic sedimentary rocks at the base of the Great Valley sequence indicate that their alteration occurred in a submarine hydrothermal system. Whole rock ??18O compositions decrease progressively down section (with increasing metamorphic grade): +22.4??? (SMOW) to +13.8 for zeolite-bearing volcaniclastic sedimentary rocks overlying the ophiolite; +19.6 to +11.6 for pumpellyite-bearing metavolcanic rocks in the upper part of the ophiolite's volcanic member; +12.3 to +8.1 for epidote-bearing metavolcanic rocks in the lower part of the volcanic member; +8.5 to +5.7 for greenschist facies rocks from the ophiolite's plutonic member; +7.6 to +5.8 for amphibolite facies or unmetamorphosed rocks from the plutonic member. Modelling of fluid-rock interaction in the Del Puerto ophiolite indicates that the observed pattern of upward enrichment in whole rock ??18O can be best explained by isotopic exchange with discharging 18O-shifted seawater at fluid/rock mass ratios near 2 and temperatures below 500??C. 18O-depleted plutonic rocks necessarily produced during hydrothermal circulation were later removed as a result of tectonism. Submarine weathering and later burial metamorphism at the base of the Great Valley sequence cannot by itself have produced the zonation of hydrothermal minerals and the corresponding variations in oxygen isotope compositions. The pervasive zeolite and prehnite-pumpellyite facies mineral assemblages found in the Del Puerto ophiolite may reflect its origin near an island arc rather than deep ocean spreading center. ?? 1984.

Schiffman, P.; Williams, A. E.; Evarts, R. C.



The imprint of subduction fluids on subducted MORB-derived melts (Sierra del Convento Mélange, Cuba)  

NASA Astrophysics Data System (ADS)

Major and trace element signatures and Sr-Nd-Pb isotope data for muscovite (Ms)-bearing amphibolite blocks and associated muscovite-bearing trondhjemite and quartz-muscovite rocks from the Sierra del Convento mélange (eastern Cuba) indicate that Proto-Caribbean oceanic crust underwent wet partial melting processes during Mesozoic subduction and after accretion to the upper plate. Trace element normalized patterns of Ms-bearing amphibolites are enriched in light rare earth elements (LREE) and large-ion lithophile elements (LILE) and evidence variable trace element transfer from the Proto-Caribbean subducting slab to the mantle wedge. Ms-bearing trondhjemites show LREE enrichment and HREE depletion and have geochemical features similar to adakites, including SiO 2 > 56 wt.%, high Na 2O contents (5.5-9.0 wt.%) and high Sr/Y (16-644). We consider that the trondhjemites represent primary and natural melts formed by deep partial melting of the subducting slab which did not significantly react with the mantle wedge before intrusion in the subduction channel. The Ms-bearing trondhjemites show different geochemical and petrological signatures compared with the Ms-free tonalites-trondhjemites from Sierra del Convento, that are interpreted as primary slab melts. These differences support the idea that partial melting processes in the Sierra del Convento subduction channel were triggered by the infiltration of fluids derived from three distinct subducted sources: sediments, altered mid-ocean ridge basalts (MORB), and serpentinites. In this scenario, the pegmatitic quartz-muscovite rocks, which are highly enriched in LILE, probably represent the crystallization products of fluids derived by differentiation of the trondhjemitic melts.

Lázaro, C.; Blanco-Quintero, I. F.; Marchesi, C.; Bosch, D.; Rojas-Agramonte, Y.; García-Casco, A.



Towards a systematic construction of realistic D-brane models on a del Pezzo singularity  

NASA Astrophysics Data System (ADS)

A systematic approach is followed in order to identify realistic D-brane models at toric del Pezzo singularities. Requiring quark and lepton spectrum and Yukawas from D3 branes and massless hypercharge, we are led to Pati-Salam extensions of the Standard Model. Hierarchies of masses, flavour mixings and control of couplings select higher order del Pezzo singularities, minimising the Higgs sector prefers toric del Pezzos with dP 3 providing the most successful compromise. Then a supersymmetric local string model is presented with the following properties at low energies: (i) the MSSM spectrum plus a local B - L gauge field or additional Higgs fields depending on the breaking pattern, (ii) a realistic hierarchy of quark and lepton masses and (iii) realistic flavour mixing between quark and lepton families with computable CKM and PMNS matrices, and CP violation consistent with observations. In this construction, kinetic terms are diagonal and under calculational control suppressing standard FCNC contributions. Proton decay operators of dimension 4, 5, 6 are suppressed, and gauge couplings can unify depending on the breaking scales from string scales at energies in the range 1012-1016 GeV, consistent with TeV soft-masses from moduli mediated supersymmetry breaking. The GUT scale model corresponds to D3 branes at dP 3 with two copies of the Pati-Salam gauge symmetry SU(4) × SU(2) R × SU(2) L . D-brane instantons generate a non-vanishing ?-term. Right handed sneutrinos can break the B - L symmetry and induce a see-saw mechanism of neutrino masses and R-parity violating operators with observable low-energy implications.

Dolan, Matthew J.; Krippendorf, Sven; Quevedo, Fernando



Lidar Investigation of Atmospheric Stratification: Del=2, 7/3, 23/9 or 3?  

NASA Astrophysics Data System (ADS)

Practically all theories of turbulence assume isotropy or at least local isotropy. In buoyancy driven flows the justification is not obvious because gravity breaks the isotropy yet acts at all scales. The classical assumption is that gravity leads to a basic stably stratified state while simultaneously postulating that the perturbations are nevertheless statistically isotropic. In the atmosphere, the scale height (about 10km) presents a further challenge: isotropic three dimensional turbulence cannot extend to very large scales. The standard model postulates an intermediate "meso-scale gap" followed at larger scales by two dimensional horizontally isotropic turbulence. Today, although we still lack consensus about the full horizontal atmospheric statistics, the meso-scale gap separating the these D=3, D=2 regimes has not been observed and there is wide consensus that the horizontal wind is scaling in the horizontal with spectral exponent ?h =5/3 out to at least several hundred km. In the vertical direction, the spectral exponent ?v > ?h implying scaling stratification with the volume of structures growing at a rate Del=2+ (?h-1)/(?v-1). The two main contending proposals being ?v =11/5 (buoyancy driven, Bolgiano-Obhukov) and ?v =3 (gravity waves, Lumley-Shur) implying Del=7/3, 23/9 respectively. In this talk we describe some recent results using state of the art lidar data of passive scalars, over the range 3m to 120km, we directly estimate Del=2.56±0.05 supporting the 23/9 dimensional "unified scaling" model . We discuss this in relation to other measurement campaigns, and also the implications for modelling the atmosphere. Finally, we show how to make multifractal models of vertical cross-sections which are very close to the data.

Lilley, M.; Lovejoy, S.; Strawbridge, K.; Schertzer, D.



Petroleum geology of the deltaic sequence, Rio Del Rey basin, offshore Cameroon  

SciTech Connect

The Rio Del Rey Basin of offshore Cameroon comprises the easternmost portion of the Niger delta complex. In the delta flank setting, the overall package is thinner and stratigraphic correlation simpler than in the depocenter to the west so the distribution of reservoirs and seals is well defined. Productive reservoirs are shallow, typically less than 2000 m, and mostly hydropressured to slightly overpressured. Reservoir properties generally are excellent and seismic bright-spot technology has played a major role in exploration and development efforts. Rio Del Rey is characterized by three main structural styles from north to south: (1) detachment-based growth faults, (2) highly faulted, mobile shale cored domes and ridges, and (3) toe thrusts and folds. Virtually all individual traps are fault dependent and lack of sufficient internal seals in sand-rich wave-dominated deltaic sequences can limit the objective window. Most fields are downthrown fault traps in which hanging-wall reservoirs are effectively sealed against older prodelta and marine shales. All large oil fields are located in the dome and ridge province and are potential analogs for similar structures now being explored on the upper slope off Nigeria. The best quality source rocks identified thus far are Paleocene to Eocene marine shales. Oil vs. gas distribution in the basin is a function of variations in the kerogen type, organic richness, and maturity of these source rocks. A significant quantity of the gas found to date in Rio Del Rey is biogenic in origin. The Cameroon charge model may aid in better understanding hydrocarbon distribution on offshore Nigeria, where the Miocene deltaic section is much thicker and potential Paleocene-Eocene source rocks likely are unpenetrated. The shallow deltaic play in Cameroon is relatively mature. Future exploration likely will focus on identifying deeper, nonbright-spot-supported opportunities including potential stratigraphic traps.

Coughlin, R.M.; Bement, W.O.; Maloney, W.V. (Pecten International Company, Houston, TX (United States))



F508del-CFTR rescue: a matter of cell stress response.  


Cystic fibrosis (CF) is a common inherited fatal disease affecting 70,000 people worldwide, with a median predicted age of survival of approximately 38 years. The deletion of Phenylalanine in position 508 of the Cystic Fibrosis Transmembrane conductance Regulator (F508del-CFTR) is the most common mutation in CF patients: the deleted protein, not properly folded, is degraded. To date no commercial drugs are available. Low temperature, some osmolytes and conditions able to induce heat shock protein 70 (Hsp70) expression and heat shock cognate 70 (Hsc70) inhibition result in F508del-CFTR rescue, hence restoring its physiological function: this review sheds light on the correlation between these several evidences. Interestingly, all these approaches have a role in the cell stress response (CSR), a set of cell reactions to stress. In addition, unpredictably, F508del-CFTR rescue has to be considered in the frame of CSR: entities that induce - or are induced during - the CSR are, in general, also able to correct trafficking defect of CFTR. Specifically, the low temperature induces, by definition, a CSR; osmolytes, such as glycerol and trimethylamine N-oxide (TMAO), are products of the CSR; pharmacological correctors, such as Matrine and 4-phenylbutirric acid (4PBA), down-regulate the constitutive Hsc70 in favor of an up-regulation of the inducible chaperone Hsp70, another component of the CSR. The identification of a common mechanism of action for different types of correctors could drive the discovery of new active molecules in CF, overcoming methods clinically inapplicable, such as the low temperature. PMID:23331026

Nieddu, Erika; Pollarolo, Benedetta; Merello, Luisa; Schenone, Silvia; Mazzei, Mauro



Oxygen isotope evidence for submarine hydrothermal alteration of the Del Puerto ophiolite, California  

NASA Astrophysics Data System (ADS)

The oxygen isotope compositions and metamorphic mineral assemblages of hydrothermally altered rocks from the Del Puerto ophiolite and overlying volcaniclastic sedimentary rocks at the base of the Great Valley sequence indicate that their alteration occurred in a submarine hydrothermal system. Whole rock ? 18O compositions decrease progressively down section (with increasing metamorphic grade): +22.4‰ (SMOW) to +13.8 for zeolite-bearing volcaniclastic sedimentary rocks overlying the ophiolite; +19.6 to +11.6 for pumpellyite-bearing metavolcanic rocks in the upper part of the ophiolite's volcanic member; +12.3 to +8.1 for epidote-bearing metavolcanic rocks in the lower part of the volcanic member; +8.5 to +5.7 for greenschist facies rocks from the ophiolite's plutonic member; +7.6 to +5.8 for amphibolite facies or unmetamorphosed rocks from the plutonic member. Modelling of fluid-rock interaction in the Del Puerto ophiolite indicates that the observed pattern of upward enrichment in whole rock ? 18O can be best explained by isotopic exchange with discharging 18O-shifted seawater at fluid/rock mass ratios near 2 and temperatures below 500°C. 18O-depleted plutonic rocks necessarily produced during hydrothermal circulation were later removed as a result of tectonism. Submarine weathering and later burial metamorphism at the base of the Great Valley sequence cannot by itself have produced the zonation of hydrothermal minerals and the corresponding variations in oxygen isotope compositions. The pervasive zeolite and prehnite-pumpellyite facies mineral assemblages found in the Del Puerto ophiolite may reflect its origin near an island arc rather than deep ocean spreading center.

Schiffman, Peter; Williams, Alan E.; Evarts, Russell C.



Soilscapes in the dynamic tropical environments: The case of Sierra Madre del Sur  

NASA Astrophysics Data System (ADS)

The paper gives an analysis of the pattern of soil cover of the Sierra Madre del Sur, one of the most complex physiographic regions of Mexico. It presents the results of the study of four latitudinal traverses across the region. We show that the distribution of soils in the Sierra Madre del Sur is associated with major climatic gradients, namely by vertical bioclimatic zonality in the mountains and by the effect of mountain shadow. Altitudinal distribution of soil-bioclimatic belts is complex due to non-uniform gradients of temperature and rainfall, and varies with the configuration of the mountain range. The distribution of soils is associated with the erosion and accumulation rates both on mountain slopes and in river valleys. The abundance of poorly developed soils in (semi)arid areas was ascribed to high erosion rate rather than to low pedogenetic potential. The formation of soil mosaic at a larger scale might be ascribed to the complex net of gully erosion and to the system of seismically triggered landslides of various ages. In the valleys, the distribution of soils depends upon the dynamics of sedimentation and erosion, which eventually exposes paleosols. Red-colored clayey sediments are remains of ancient weathering and pedogenesis. Their distribution is associated mainly with the intensity of recent slope processes. The soil cover pattern of the Sierra Madre del Sur cannot be explained by simplified schemes of bioclimatic zonality. The soil ranges can be explained by the distribution of climates, lithology, complex geological history of the region, and recent geomorphological processes.

Krasilnikov, P. V.; García-Calderón, N. E.; Ibáñez-Huerta, A.; Bazán-Mateos, M.; Hernández-Santana, J. R.



Developing market class specific InDel markers from next generation sequence data in Phaseolus vulgaris L.  


Next generation sequence data provides valuable information and tools for genetic and genomic research and offers new insights useful for marker development. This data is useful for the design of accurate and user-friendly molecular tools. Common bean (Phaseolus vulgaris L.) is a diverse crop in which separate domestication events happened in each gene pool followed by race and market class diversification that has resulted in different morphological characteristics in each commercial market class. This has led to essentially independent breeding programs within each market class which in turn has resulted in limited within market class sequence variation. Sequence data from selected genotypes of five bean market classes (pinto, black, navy, and light and dark red kidney) were used to develop InDel-based markers specific to each market class. Design of the InDel markers was conducted through a combination of assembly, alignment and primer design software using 1.6× to 5.1× coverage of Illumina GAII sequence data for each of the selected genotypes. The procedure we developed for primer design is fast, accurate, less error prone, and higher throughput than when they are designed manually. All InDel markers are easy to run and score with no need for PCR optimization. A total of 2687 InDel markers distributed across the genome were developed. To highlight their usefulness, they were employed to construct a phylogenetic tree and a genetic map, showing that InDel markers are reliable, simple, and accurate. PMID:24860578

Moghaddam, Samira Mafi; Song, Qijian; Mamidi, Sujan; Schmutz, Jeremy; Lee, Rian; Cregan, Perry; Osorno, Juan M; McClean, Phillip E



Structural analog of sildenafil identified as a novel corrector of the F508del-CFTR trafficking defect.  


The F508del mutation impairs trafficking of the cystic fibrosis transmembrane conductance regulator (CFTR) to the plasma membrane and results in a partially functional chloride channel that is retained in the endoplasmic reticulum and degraded. We recently used a novel high-throughput screening (HTS) assay to identify small-molecule correctors of F508del CFTR trafficking and found several classes of hits in a screen of 2000 compounds (Carlile et al., 2007). In the present study, we have extended the screen to 42,000 compounds and confirmed sildenafil as a corrector using this assay. We evaluated structural analogs of sildenafil and found that one such molecule called KM11060 (7-chloro-4-{4-[(4-chlorophenyl) sulfonyl] piperazino}quinoline) was surprisingly potent. It partially restored F508del trafficking and increased maturation significantly when baby hamster kidney (BHK) cells were treated with 10 nM for 24 h or 10 muM for 2 h. Partial correction was confirmed by the appearance of mature CFTR in Western blots and by using halide flux, patch-clamp, and short-circuit current measurements in unpolarized BHK cells, monolayers of human airway epithelial cells (CFBE41o(-)), and intestines isolated from F508del-CFTR mice (Cftr(tm1Eur)) treated ex vivo. Small-molecule correctors such as KM11060 may serve as useful pharmacological tools in studies of the F508del-CFTR processing defect and in the development of cystic fibrosis therapeutics. PMID:17975008

Robert, Renaud; Carlile, Graeme W; Pavel, Catalin; Liu, Na; Anjos, Suzana M; Liao, Jie; Luo, Yishan; Zhang, Donglei; Thomas, David Y; Hanrahan, John W



Developing market class specific InDel markers from next generation sequence data in Phaseolus vulgaris L.  

PubMed Central

Next generation sequence data provides valuable information and tools for genetic and genomic research and offers new insights useful for marker development. This data is useful for the design of accurate and user-friendly molecular tools. Common bean (Phaseolus vulgaris L.) is a diverse crop in which separate domestication events happened in each gene pool followed by race and market class diversification that has resulted in different morphological characteristics in each commercial market class. This has led to essentially independent breeding programs within each market class which in turn has resulted in limited within market class sequence variation. Sequence data from selected genotypes of five bean market classes (pinto, black, navy, and light and dark red kidney) were used to develop InDel-based markers specific to each market class. Design of the InDel markers was conducted through a combination of assembly, alignment and primer design software using 1.6× to 5.1× coverage of Illumina GAII sequence data for each of the selected genotypes. The procedure we developed for primer design is fast, accurate, less error prone, and higher throughput than when they are designed manually. All InDel markers are easy to run and score with no need for PCR optimization. A total of 2687 InDel markers distributed across the genome were developed. To highlight their usefulness, they were employed to construct a phylogenetic tree and a genetic map, showing that InDel markers are reliable, simple, and accurate.

Moghaddam, Samira Mafi; Song, Qijian; Mamidi, Sujan; Schmutz, Jeremy; Lee, Rian; Cregan, Perry; Osorno, Juan M.; McClean, Phillip E.



Further spectroscopic observations of Nova Del 2013 = PNV J20233073+2046041 with the Ondrejov Observatory  

NASA Astrophysics Data System (ADS)

We report high resolution results (0.23A at 6563A) results for the newly announced nova Del 2013 = PNV J20233073+2046041. These extend the report by Darnley et al. (ATEL #5279) based on low resolution spectra. Our grating spectra, obtained on 2013 Aug. 14.87 with the coude spectrograph at the 2 meter Zeiss telescope of the Ondrejov Observatory, shows strong H-alpha emission with a P Cyg profile extending to a maximum radial velocities of -2300 km/s (absorption, EW approx 8.1A) and +2400 km/s (emission, EW approx 52.9A) with no terminal edge at high negative velocity.

Shore, S. N.; Skoda, P.; Rutsch, P.



Early neogene history of the central American arc from Bocas del Toro, western Panama  

USGS Publications Warehouse

A newly discovered sequence of lower to middle Miocene rocks from the eastern Bocas del Toro archipelago, western Panama, reveals the timing and environment of the earliest stages in the rise of the Isthmus of Panama in this region. Two new formations, the Punta Alegre Formation (lower Miocene, Aquitanian to Burdigalian) and the Valiente Formation (middle Miocene, Langhian to Serravallian), are here named and formally described. The Punta Alegre Formation contains a diagnostic microfauna of benthic and planktic foraminifera and calcareous nannofossils that indicate deposition in a 2000-m-deep pre-isthmian neotropical ocean from as old as 21.5-18.3 Ma. Its lithology varies from silty mudstone to muddy foraminiferal ooze with rare thin microturbidite layers near the top. The Valiente Formation, which ranges in age from 16.4 to ca. 12.0 Ma, lies with slight angular unconformity on the Punta Alegre Formation and consists of five lithofacies: (1) columnar basalt and flow breccia, (2) pyroclastic deposits, (3) coarse-grained volcaniclastic deposits, (4) coral-reef limestone with diverse large coral colonies, and (5) marine debris-flow deposits and microturbidities. These lithofacies are interpreted to indicate that after ca. 16 Ma a volcanic arc developed in the region of Bocas del Toro and that by ca. 12 Ma an extensively emergent archipelago of volcanic islands had formed. 39Ar/40Ar dating of basalt flows associated with the fossiliferous sedimentary rocks in the upper part of the Valiente Formation strongly confirms the ages derived from planktic foraminifera and nannofossils. Paleobathymetric analysis of the two new formations in the Valiente Peninsula and Popa Island, in the Bocas del Toro archipelago, shows a general shallowing from lower- through upper-bathyal to upper-neritic and emergent laharic and fluviatile deposits from ca. 19 to 12 Ma. The overlying nonconformable Bocas del Toro Group contains a lower transgressive sequence ranging from basal nearshore sandstone to upper-bathyal mudstone (ca. 8.1-5.3. Ma) and an upper regressive sequence (5.3-3.5 Ma). A similar paleobathymetric pattern is observed from the Gatun to Chagres Formations (12-6 Ma) in the Panama Canal Basin area and in the Uscari, Rio Banana, Quebrada Chocolate, and Moin Formations (8-1.7 Ma) in the southern Limo??n Basin of Costa Rica.

Coates, A. G.; Aubry, M. -P.; Berggren, W. A.; Collins, L. S.; Kunk, M.



Holocene paleoclimate characterization in Lago Fagnano (Tierra del Fuego) using sedimentary, physical and geochemical proxies  

NASA Astrophysics Data System (ADS)

Tierra del Fuego is the world's southernmost landmass outside of Antarctica. Two features of ocean circulation control the climate of Tierra del Fuego: the Southern Ocean circumpolar flow and the South Pacific Gyre. Together with Patagonia, Tierra del Fuego is the only terrestrial region directly influenced by the southern hemisphere westerly winds. This region is also a tectonically active area affected by volcanic and seismic activity related to South American and Scotia-Antarctic plate boundaries. Accommodated along the Magallanes-Fagnano fault system, as part of the plate boundary, the Lago Fagnano is the largest lake in Tierra del Fuego. This E-W trending lake is 100 km long and 5-15 km wide. Our investigations were carried out on the upper 4 meters of an 8.4 m long piston core obtained at 69 m water depth in Bahía Grande (LF06-PC8); a southwestern lake sub-basin separated from the main lake by a shallow sill. Our studies are based on the integration of sediment description, physical properties, pollen, and geochemical analyses including C and N isotopes (1cm interval) and XRF scan (1mm interval). The age model for the core is based on radiocarbon ages and tephrochronology. Additionally, a 800 km long grid of high resolution seismic profiles support the sedimentary analyses and allow the correlation with other cores from within the lake basin. LF06-PC8 yields continuous and high accumulation-rate sedimentary sections for Lago Fagnano. The presented sediment record corresponds to a laminated hemipelagite with presence of a single but complex mass transport deposit interval. An accurate sedimentological interpretation of the core together with the radiocarbon ages and tephra dates allow to identify and characterize the main sedimentary processes occurring in the lake over the last 8 kyr. In addition, proxy data (C and N isotopes and XRF scan data) from the laminated hemipelagic interval provide a reliable record of past variability in the westerly wind field as well as the regional precipitation regime. The very high frequency measurements from XRF scan allows us to obtain decadal scale resolution from the lamination. Pollen analysis identifies local shifts in the forest-steppe ecotone over time. Results from this core represent an important contribution to our knowledge of Southern South American Holocene paleoclimate. Its ideal location in a climatically sensitive and hydrologically protected site, its stratigraphic integrity, and the high temporal resolution of the isotopic record as a consequence of the short residence time of water in the lake, and its proximity to a dense network of paleoclimate records from the region provide a unique paleoclimate reconstruction for this region.

Vizcaino Marti, A.; Dunbar, R. B.; Wahl, D.; Moy, C. M.; Mucciarone, D. A.; Anderson, L.; Guilderson, T. P.



Matuyama-age lithic tools from the Sima del Elefante site, Atapuerca (northern Spain).  


Paleomagnetic results obtained from the sedimentary fill at the Sima del Elefante site in Atapuerca, Spain, reveal a geomagnetic reversal, interpreted as the Matuyama-Brunhes boundary (0.78 Ma). The uppermost lithostratigraphic units (E17 through E19), which contain Mode II and III archaeological assemblages, display normal polarity magnetization, whereas the six lowermost units (E9 through E16) yield negative latitudinal virtual geomagnetic pole positions. Units E9 through E13, all of which display reverse magnetic polarity, contain Mode I (Oldowan) lithic tools, testifying to the presence of humans in the early Pleistocene (0.78-1.77 Ma). PMID:16249015

Parés, Josep M; Pérez-González, Alfredo; Rosas, Antonio; Benito, A; Bermúdez de Castro, J M; Carbonell, E; Huguet, R



Spectroscopy of the very fast Nova Del 2013, already declining past maximum brightness  

NASA Astrophysics Data System (ADS)

Nova Del 2013 seems to have reached maximum brightness on August 16.45 UT at V=4.3 mag. It immediately entered the decline phase and it is declining pretty fast, of the order of 1 mag in a day, qualifying it as a very fast nova if the pace will be maintained on the coming days. Also the rise toward maximum has been real fast, 2 mag in about 1.5 days according to our photometry and AAVSO database. The total outburst amplitude is 12.6 mag in V, adopting V=16.9 mag for the progenitor as given by GSC 2.3.2.

Munari, U.; Valisa, P.; Milani, A.; Cetrulo, G.



Uranium series dating of human skeletal remains from the Del Mar and Sunnyvale sites, California  

SciTech Connect

Uranium series analyses of human bone samples from the Del Mar and Sunnyvale sites indicate ages of 11,000 and 8300 years, respectively. The dates are supported by internal concordancy between thorium-230 and protactinium-231 decay systems. These ages are significantly younger than the estimates of 48,000 and 70,000 years based on amino acid racemization, and indicate that the individuals could derive from the population waves that came across the Bering Strait during the last sea-level low.

Bischoff, J.L.; Rosenbauer, R.J.



Uranium series dating of human skeletal remains from the del mar and sunnyvale sites, california.  


Uranium series analyses of human bone samples from the Del Mar and Sunnyvale sites indicate ages of 11,000 and 8,300 years, respectively. The dates are supported by internal concordancy between thorium-230 and protactinium-231 decay systems. These ages are significantly younger than the estimates of 48,000 and 70,000 years based on amino acid racemization, and indicate that the individuals could derive from the population waves that came across the Bering Strait during the last sea-level low. PMID:17789030

Bischoff, J L; Rosenbauer, R J



After a post-maximum plateau Nova Del 2013 has begun a normal decline  

NASA Astrophysics Data System (ADS)

The rise toward maximum of Nova Del 2013 was extremely fast. On unfiltered pre-discovery images for Aug 13.998 UT by Denisenko et al. (CBET 3628), the nova was still at 17.1 mag, close to its quiescence value (the average magnitude of the progenitor on Palomar I and II plates is B=17.3 and R=17.6 according to USNO-B1 catalog data, and V=16.9 following GSC ver 2.3.2). When the nova was discovered by K.

Munari, U.; Dallaporta, S.; Cherini, G.; Valisa, P.; Cetrulo, G.; Milani, A.; Ghirotto, L.



125-Day Spectral Record of the Bright Nova Delphini 2013 (V339 Del)  

NASA Astrophysics Data System (ADS)

A 125-day spectral record of the evolution of Nova Delphini 2013 (V339 Del), which erupted on August 14, 2013, is presented. Spectra were acquired with a low-resolution 100 line per millimeter grating. Records were acquired beginning one day after discovery and a total of forty-four spectra were analyzed. Despite the low resolution, major phases of evolution of this accreting-white-dwarf nova were recorded. These phases can be readily identified by the oxygen, iron, and nitrogen emission spectra within the range of most commercially available astronomical cameras (e.g. CCD and DSLR).

Mooers, H. D.; Wiethoff, W. S.



Stratigraphic context and direct dating of the Neandertal mandible from Cova del Gegant (Sitges, Barcelona).  


Stratigraphic study of the Cova del Gegant's sedimentary fill revealed different cycles of accumulation of typical interior cave and delta facies. A precise chronology for these deposits, the faunal remains and stone tools contained therein was obtained by radiocarbon, U-Th and OSL. Our results indicate that the Upper Pleistocene archaeological sequence dates between 49.3 +/- 1.8 ka BP, the U-Th age of the overlying flowstone, and 60.0 +/- 3.9 ka BP, the OSL age of the basal deposits. We have also directly dated the site's Neandertal mandible to 52.3 +/- 2.3 ka by U-Th. PMID:20570316

Daura, J; Sanz, M; Pike, A W G; Subirà, M E; Fornós, J J; Fullola, J M; Julià, R; Zilhão, J



Invertebrate fauna associated with Torpedograss, Panicum repens (Cyperales: Poaceae), in Lake Okeechobee, Florida, and prospects for biological control  

SciTech Connect

Torpedograss, Panicum repens L., is an adventive, rhizomatous grass species that has become an invasive weed of terrestrial, wetland, and aquatic environments in tropical and subtropical regions worldwide. Until recently, strategies for controlling torpedograss in the USA have focused almost exclusively on mechanical and chemical methods, either alone or in combination, with varied results. A survey of the arthropods and nematodes currently associated with the plant in Lake Okeechobee, Florida, was conducted as part of a feasibility study to determine whether torpedograss is an appropriate target for a classical biological control program. Overall, approximately 4,000 arthropods and 400 nematode specimens were collected. Sweep, clipped vegetation, and soil core samples were dominated by representatives of the arthropod orders Hemiptera, Hymenoptera, Diptera, and Acari. Lesion nematodes of the genus Pratylenchus were commonly associated with the roots of torpedograss. None of the organisms collected were torpedograss specialists. Although classical biological control of torpedograss is feasible based on the extent of the infestation, economic losses, resistance to conventional controls, and the report of a potentially host specific natural enemy in India, the botanical position of this grass weed will require a formal risk assessment before proceeding with a classical biological control program. (author) [Spanish] La conota, Panicum repens L., es una especie foranea de pasto que produce rizomas que ha convertido en ser una maleza invasora de ambientes terrestres, pantanosos y acuaticos en regiones tropicales y subtropicales en todo el mundo. Hasta hace un tiempo reciente, las estrategias para controlar conota en los EEUU eran enfocadas casi exclusivamente en los metodos mecanicos y quimicos, solos o en combinacion, con resultados variables. Un muestreo de los artropodos y nematodos asociados corrientemente con esta planta en el Lago de Okeechobee, Florida, fue realizado como parte de un estudio de factibilidad para determinar si conota es una candidata apropiada para un programa de control biologico clasico. En general, especimenes de aproximadamente unos 4,000 artropodos y unos 400 nematodos fueron recolectados. Muestras recolectadas pasando una red sobre vegetacion mezclada, cortando la vegetacion y tomando centros del suelo fueron dominados por representantes de artropodos de los ordenes de Hemiptera, Hymenoptera, Diptera, y Acari. Nematodos en el genero Pratylenchus, que causan lesiones sobre tejido, fueron asociados regularmente con las raices de conota. Ninguno de los organismos recolectados eran especialistas sobre conota. Aunque el control biologico clasico de la conota es factible basado sobre la magnitud de la infestacion, las perdidas economicas, la resistencia hacia los metodos de control convencionales y el informe en la India de un posible enemigo natural especifico a esta planta, la posicion botanica de este pasto maleza requiere una evaluacion de riesgo economico formal antes de continuar con un programa de control biologico clasico. (author)

Cuda, J.P.; Dunford, J.C.; Leavengood, J.M. Jr. [University of Florida, Entomology and Nematology Department, Gainesville, FL 32611-0620 (United States)



Aplicación del \\  

Microsoft Academic Search

SUMMARY The MINI (International Mini Neuropsychiatric Interview) is a brief and high structured interview of the main psychiatric disorders of the IDC - 10 and DSM-IV in order to be employed by psychiatrists and physi- cians not psychiatrists afterwards short time training. It was elaborated by Y. Lecrubier from the \\



The spectrum of somatic mutations in high-risk acute myeloid leukaemia with -7/del(7q).  


-7/del(7q) occurs in half of myeloid malignancies with adverse-risk cytogenetic features and is associated with poor survival. We identified the spectrum of mutations that co-occur with -7/del(7q) in 40 patients with de novo or therapy-related myeloid neoplasms. -7/del(7q) leukaemias have a distinct mutational profile characterized by low frequencies of alterations in genes encoding transcription factors, cohesin and DNA-methylation-related proteins. In contrast, RAS pathway activating mutations occurred in 50% of cases, a significantly higher frequency than other acute myeloid leukaemias and higher than previously reported. Our data provide guidance for which pathways may be most relevant in the treatment of adverse-risk myeloid leukaemia. PMID:24931631

McNerney, Megan E; Brown, Christopher D; Peterson, April L; Banerjee, Mekhala; Larson, Richard A; Anastasi, John; Le Beau, Michelle M; White, Kevin P



Superfund Record of Decision (EPA Region 9): Del Amo Facility Waste Pits Operable Unit, Los Angeles, CA, September 5, 1997  

SciTech Connect

This decision document presents the selected remedial action for the Del Amo Waste Pits Operable Unit (Waste Pits OU) of the Proposed Del Amo Superfund Site (Del Amo Site), in Los Angeles, California. The remedy selected in this ROD addresses the principal threat remaining at the Waste Pits Area by selecting actions that will prevent future releases of hazardous substances from the remaining waste materials present in the waste pits, either upward to the surface, downward into the groundwater, or laterally out from the pits, that would create unacceptable risks to public health or welfare or the environment. The ROD also selects measures intended to prevent additional contamination of groundwater beneath the Waste Pits Area by selecting response actions to clean-up hazardous substance contamination that had been previously releases from the waste pits and is currently present in the vadose zone soils.




Mosaicism for del(17)(p11.2p11.2) underlying the Smith-Magenis syndrome.  


Smith-Magenis syndrome (SMS) is a multiple congenital anomalies/mental retardation syndrome associated with deletion of band p11.2 of chromosome 17. The deletion is typically detected by high-resolution cytogenetic analysis of chromosomes from peripheral lymphocytes. Fluorescence in situ hybridization (FISH) has been previously used to rule out apparent mosaicism for del(17)(p11.2p11.2) indicated by routine cytogenetics. We now report mosaicism for del(17)(p11.2p11.2) in a child with SMS. The mosaicism had gone undetected during previous routine cytogenetic analysis. FISH analysis of peripheral lymphocytes as well as immortalized lymphoblasts using markers from 17p11.2 revealed that approximately 60% of cells carried the deletion. To our knowledge, this is the first case of SMS associated with mosaicism for del(17)(p11.2p11.2). PMID:8958329

Juyal, R C; Kuwano, A; Kondo, I; Zara, F; Baldini, A; Patel, P I



The effect of the common c.2299delG mutation in USH2A on RNA splicing.  


Recessive variants in the USH2A gene are an important cause of both Usher syndrome and nonsyndromic retinitis pigmentosa. A single base-pair deletion in exon 13 (c.2299delG, p.Glu767Serfs*21) is considered the most frequent mutation of USH2A. It is predicted to generate a premature termination codon and is presumed to lead to nonsense mediated decay. However the effect of this variant on RNA has not been formally investigated. It is not uncommon for exonic sequence alterations to cause aberrant splicing and the aim of the present report is to evaluate the effect of c.2299delG on USH2A transcripts. Nasal cells represent the simplest available tissue to study splicing defects in USH2A. Nasal brushing, RNA extraction from nasal epithelial cells and reverse transcription PCR were performed in five Usher syndrome patients who were homozygous for c.2299delG, two unaffected c.2299delG heterozygotes and seven control individuals. Primers to amplify between exons 12 and 15 and exons 10 and 14 were utilised. Significant variability was observed between different RT-PCR experiments. Importantly, in controls, PCR product of the expected size were amplified on all occasions (13/13 experiments); for patients this was true in only 4/14 experiments (Fisher exact test p = 0.0002). Bioinformatics tools predict the c.2299delG change to disrupt an exonic splicing enhancer and to create an exonic splicing silencer within exon 13. Here, we report an effect of the common c.2299delG mutation on splicing of exons 12 and 13 of USH2A. Future studies are expected to provide important insights into the contribution of this effect on the phenotype. PMID:24607488

Lenassi, Eva; Saihan, Zubin; Bitner-Glindzicz, Maria; Webster, Andrew R



Impact of the cystic fibrosis mutation F508del-CFTR on renal cyst formation and growth.  


In autosomal dominant polycystic kidney disease (ADPKD), cystic fibrosis transmembrane conductance regulator (CFTR), the protein product of the gene defective in cystic fibrosis (CF), plays a crucial role in fluid accumulation, which promotes cyst swelling. Several studies have identified individuals afflicted by both ADPKD and CF. Two studies suggested that CF mutations might attenuate the severity of ADPKD, whereas a third found no evidence of a protective effect. In this study, we investigated the impact of the commonest CF mutation F508del-CFTR on the formation and growth of renal cysts. As a model system, we used Madin-Darby canine kidney (MDCK) epithelial cells engineered to express wild-type and F508del human CFTR. We grew MDCK cysts in collagen gels in the presence of the cAMP agonist forskolin and measured transepithelial resistance and Cl(-) secretion with the Ussing chamber technique and assayed cell proliferation using nonpolarized MDCK cells. When compared with untransfected MDCK cells, cells expressing wild-type CFTR generated substantial numbers of large cysts, which grew markedly over time. By contrast, MDCK cells expressing F508del-CFTR formed very few tiny cysts that failed to enlarge. Interestingly, treatment of F508del-CFTR cysts with the CFTR corrector VRT-325 and the CFTR corrector-potentiator VRT-532 increased the number, but not size, of F508del-CFTR cysts, possibly because VRT-325 inhibited strongly cell proliferation. Based on its effects on transepithelial resistance, Cl(-) secretion, and cell proliferation, we conclude that the F508del-CFTR mutation disrupts cyst formation and growth by perturbing strongly fluid accumulation within the cyst lumen without compromising epithelial integrity. PMID:22874761

Li, Hongyu; Yang, Wanding; Mendes, Filipa; Amaral, Margarida D; Sheppard, David N



La Transpiración - Movimiento del Agua a Través de las Plantas  

NSDL National Science Digital Library

La transpiración es la pérdida de agua en forma de vapor por las plantas. El agua es absorbida del suelo por las raíces y transportada en forma líquida por el xilema hacia las hojas. En las hojas, unos pequeños poros permiten que el agua (H2O) escape a la atmósfera en forma de vapor, al tiempo que se permite la entrada de bióxido de carbono (CO2) para la fotosíntesis. De toda el agua absorbida por las plantas, menos del 5% es retenida y utilizada para crecimiento y almacenamiento. En esta lección se explicará porque las plantas pierden tanta agua, la ruta que ésta sigue dentro de la planta, como pudieran las plantas controlar la pérdida excesiva de agua y como las condiciones ambientales influyen en la pérdida de agua por las plantas.


Response to lenalidomide in myelodysplastic syndromes with del(5q): influence of cytogenetics and mutations.  


Lenalidomide is an effective drug in low-risk myelodysplastic syndromes (MDS) with isolated del(5q), although not all patients respond. Studies have suggested a role for TP53 mutations and karyotype complexity in disease progression and outcome. In order to assess the impact of complex karyotypes on treatment response and disease progression in 52 lenalidomide-treated patients with del(5q) MDS, conventional G-banding cytogenetics (CC), single nucleotide polymorphism array (SNP-A), and genomic sequencing methods were used. SNP-A analysis (with control sample, lymphocytes CD3+, in 30 cases) revealed 5q losses in all cases. Other recurrent abnormalities were infrequent and were not associated with lenalidomide responsiveness. Low karyotype complexity (by CC) and a high baseline platelet count (>280 × 10(9) /l) were associated with the achievement of haematological response (P = 0·020, P = 0·013 respectively). Unmutated TP53 status showed a tendency for haematological response (P = 0·061). Complete cytogenetic response was not observed in any of the mutated TP53 cases. By multivariate analysis, the most important predictor for lenalidomide treatment failure was a platelet count <280 × 10(9) /l (Odds Ratio = 6·17, P = 0·040). This study reveals the importance of a low baseline platelet count, karyotypic complexity and TP53 mutational status for response to lenalidomide treatment. It supports the molecular study of TP53 in MDS patients treated with lenalidomide. PMID:23614682

Mallo, Mar; Del Rey, Mónica; Ibáñez, Mariam; Calasanz, M José; Arenillas, Leonor; Larráyoz, M José; Pedro, Carmen; Jerez, Andrés; Maciejewski, Jaroslaw; Costa, Dolors; Nomdedeu, Meritxell; Diez-Campelo, María; Lumbreras, Eva; González-Martínez, Teresa; Marugán, Isabel; Such, Esperanza; Cervera, José; Cigudosa, Juan C; Alvarez, Sara; Florensa, Lourdes; Hernández, Jesús M; Solé, Francesc



Neurobiolog?a del autismo y TDAH mediante t?cnicas de neuroimagen: divergencias y convergencias  

PubMed Central

En el área clínica algunos síntomas del trastorno por déficit de atención e hiperactividad (TDAH), se presentan en los pacientes con trastorno del espectro autista (TEA). Se ha demostrado que existen alteraciones en circuitos cerebrales que impactan en fallas cognitivas y de comportamiento específicas de cada uno de estos trastornos. Sin embargo, han sido poco estudiados los correlatos cerebrales que hay detrás tanto de las similitudes como de las diferencias sintomatológicas. En la presente revisión se analizaron los estudios meta-analíticos existentes estructurales y funcionales en TDAH y TEA. Por un lado, se observaron convergencias en circuitos como el dorsal atencional, de funciones ejecutivas, visual, somatomotor y circuito de activación por defecto. Estas similitudes posiblemente explican las manifestaciones comórbidas entre los trastornos como la falla en la integración de información, motricidad fina y procesos atencionales específicos. Por otro lado, específicamente en el TDAH se observan déficits en el circuito de recompensa y ventral atencional, sistemas involucrados en la medición de efectos de reforzamiento y monitoreo atencional. En TEA los circuitos más afectados fueron los implicados en procesos de cognición social y lenguaje. En conclusión, existen correlatos neuronales en TEA que explican las manifestaciones clínicas tanto convergentes como divergentes presentes en TDAH.

Proal, Erika; Olvera, Jorge Gonzalez; Blancas, Aurea S.; Chalita, Pablo J.; Castellanos, F. Xavier



DelPhi webserver: Comprehensive suite for electrostatic calculations of biological macromolecules and their complexes  

NASA Astrophysics Data System (ADS)

Electrostatic forces and energies are two of the major components that contribute to the stability, function and interaction of biological macromolecules. The calculations of the electrostatic potential distribution in such systems, which are comprised of irregularly shaped objects immersed in a water phase, is not a trivial task. In addition, an accurate model requires any missing hydrogen atoms of the corresponding structural files (Protein Data Bank, or, PDB files) to be generated in silico and, if necessary, missing atoms or residues to be predicted as well. Here we report a comprehensive suite, an academic DelPhi webserver, which allows the users to upload their structural file, calculate the components of the electrostatic energy, generate the corresponding potential (and/or concentration/dielectric constant) distribution map, and choose the appropriate force field. The webserver utilizes modern technology to take user input and construct an algorithm that suits the users specific needs. The webserver uses Clemson University's Palmetto Supercomputer Cluster to handle the DelPhi calculations, which can range anywhere from small and short computation times, to extensive and computationally demanding runtimes. The work was supported by a grant from NIGMS, NIH, grant number 1R01GM093937-01.

Witham, Shawn; Boylen, Brett; Owesen, Barr; Rocchia, Walter; Alexov, Emil



Large residuals on geoidal heights determined on the Fagnano Lake, Tierra del Fuego-Argentina  

NASA Astrophysics Data System (ADS)

A new geoid model was developed in Tierra del Fuego and it was evaluated in the area of Fagnano Lake. The model was developed by means of the Equivalent Source Technique combining gravity data, levelling information measured on the province and observations of a GPS buoy on the Fagnano Lake. Those GPS buoy measurements provide information of the mean lake level surface (Del Cogliano et al., 2007). A cross validation process was realized in order to evaluate the model on the lake. What allowed determining a 6 cm geoid in the area of Fagnano Lake. Also, an evaluation of the EGM2008 (Pavlis et al., 2008) was made on the lake. Its behaviour was compared to that observed on the levelling lines. Differences of several decimetres were found when EGM2008 undulations were compared to observed geoid undulations in the lake area. In the regions where EGM2008 has included real gravimetric observations, differences between model and observations were only of a few centimetres. Such model has the particularity that includes fill-in gravity in that region. The above mentioned evaluation derived in an analysis of the effect that not representative gravity information could have on the estimation of geoid undulations in high mountainous regions. We found that this effect could be significant if there is no real information in the computing area (Gomez et al, 2012).

Gomez, M. E.; Del Cogliano, D.; Perdomo, R.



Small molecule correctors of F508del-CFTR discovered by structure-based virtual screening.  


Folding correctors of F508del-CFTR were discovered by in silico structure-based screening utilizing homology models of CFTR. The intracellular segment of CFTR was modeled and three cavities were identified at inter-domain interfaces: (1) Interface between the two Nucleotide Binding Domains (NBDs); (2) Interface between NBD1 and Intracellular Loop (ICL) 4, in the region of the F508 deletion; (3) multi-domain interface between NBD1:2:ICL1:2:4. We hypothesized that compounds binding at these interfaces may improve the stability of the protein, potentially affecting the folding yield or surface stability. In silico structure-based screening was performed at the putative binding-sites and a total of 496 candidate compounds from all three sites were tested in functional assays. A total of 15 compounds, representing diverse chemotypes, were identified as F508del folding correctors. This corresponds to a 3% hit rate, ~tenfold higher than hit rates obtained in corresponding high-throughput screening campaigns. The same binding sites also yielded potentiators and, most notably, compounds with a dual corrector-potentiator activity (dual-acting). Compounds harboring both activity types may prove to be better leads for the development of CF therapeutics than either pure correctors or pure potentiators. To the best of our knowledge this is the first report of structure-based discovery of CFTR modulators. PMID:20976528

Kalid, Ori; Mense, Martin; Fischman, Sharon; Shitrit, Alina; Bihler, Hermann; Ben-Zeev, Efrat; Schutz, Nili; Pedemonte, Nicoletta; Thomas, Philip J; Bridges, Robert J; Wetmore, Diana R; Marantz, Yael; Senderowitz, Hanoch



Influence of North American Sources on Sulfate at Sagres and Punta del Hidalgo During ACE-2  

NASA Astrophysics Data System (ADS)

A hemispheric-scale Eulerian model has been used to ascertain sources of sulfate at Sagres, southwestern Portugal, and Punta del Hidalgo, Canary Islands, during the ACE-2 project, June-July, 1997. At both locations time series of modeled sulfate mixing ratios closely track the observations for the entire duration of the project. At Sagres sulfate was dominated by contributions from European sources, except for brief periods where contributions from biogenic sources were comparable. At Punta del Hidalgo European, North American, and biogenic sources each contributed comparably to sulfate mixing ratios, with no single source consistently dominating over the time period. Transport of sulfate from North American emissions across the North Atlantic was driven by the general synoptic features which included a persistent Azores high and an Icelandic low; animations of the transport of sulfate from the several source regions (to be shown during the presentation) facilitate the display and interpretation of the influence of the synoptic conditions on formation and transport of sulfate. These calculations provide quantitative model confirmation of earlier suggestions, based on back trajectories, of the influence of North American sources on aerosol loadings at these locations. These findings highlight the importance of long-range transport not only in influencing aerosol radiative forcing over oceans but also in affecting air quality and climate in downwind areas and point to ways to determine the influences of specific source regions.

Benkovitz, C. M.; Schwartz, S. E.; Kim, B.



Implementation of tsunami disaster prevention measures in the municipality of San Rafael del Sur, Nicaragua  

NASA Astrophysics Data System (ADS)

The Nicaraguan Pacific coast presents considerable tsunami risk. On September 1, 1992, a tsunami caused enormous damage in the infrastructure and killed more than 170 people. A pilot project was conducted between 2006 and 2007 in the municipality of San Rafel del Sur, area of Masachapa, The project included multiple topics of tsunami prevention measures and considering the direct participation of the local population, as: -General education on disaster prevention, participative events; -Investigation of awareness level and information needs for different population groups; -Specific educational measures in the schools; -Publication of brochures, calendars, news paper articles, radio programs, TV spots -Development of local tsunami hazard maps, 1:5,000 scale; (based on previous regional tsunami hazard mapping projects and local participation) -Development of a tsunami warning plan; -Improvements of the national tsunami warning system. -Installation of sirens for tsunami warning -Installation of tsunami signs, indicating hazardous areas, evacuation routes, safe places; -Realization of evacuation drills in schools. Based on the experiences gained in Masachapa it is planned to run similar projects in other areas along the Nicaraguan Pacific coast. In the project participated the local municipality and local stakeholders of San Rafael del Sur, Ministry of Education, National Police, Nicaraguan Red Cross, Ministry of Health, Ministry of Tourism, Nicaraguan Geosciences Institute (INETER), National System for Disaster Prevention (SINAPRED), Swiss Agency for Development and Cooperation (SDC). It was financed by SDC and INETER.

Strauch, W.; Talavera, E.; Acosta, N.; Sanchez, M.; Mejia, E.



Small molecule correctors of F508del-CFTR discovered by structure-based virtual screening  

PubMed Central

Folding correctors of F508del-CFTR were discovered by in silico structure-based screening utilizing homology models of CFTR. The intracellular segment of CFTR was modeled and three cavities were identified at inter-domain interfaces: (1) Interface between the two Nucleotide Binding Domains (NBDs); (2) Interface between NBD1 and Intracellular Loop (ICL) 4, in the region of the F508 deletion; (3) multi-domain interface between NBD1:2:ICL1:2:4. We hypothesized that compounds binding at these interfaces may improve the stability of the protein, potentially affecting the folding yield or surface stability. In silico structure-based screening was performed at the putative binding-sites and a total of 496 candidate compounds from all three sites were tested in functional assays. A total of 15 compounds, representing diverse chemotypes, were identified as F508del folding correctors. This corresponds to a 3% hit rate, ?tenfold higher than hit rates obtained in corresponding high-throughput screening campaigns. The same binding sites also yielded potentiators and, most notably, compounds with a dual corrector-potentiator activity (dual-acting). Compounds harboring both activity types may prove to be better leads for the development of CF therapeutics than either pure correctors or pure potentiators. To the best of our knowledge this is the first report of structure-based discovery of CFTR modulators.

Mense, Martin; Fischman, Sharon; Shitrit, Alina; Bihler, Hermann; Ben-Zeev, Efrat; Schutz, Nili; Pedemonte, Nicoletta; Thomas, Philip J.; Bridges, Robert J.; Wetmore, Diana R.; Marantz, Yael; Senderowitz, Hanoch



Marine habitats map of "Isla del Caño", Costa Rica, comparing Quickbird and Hymap images classification results.  


Isla del Caño is a marine protected area on the south Pacific coast of Costa Rica, surrounded by coral reefs and coral communities. The ecology of these coral reefs has been studied for over 20 years, but they have not been mapped. Maps are considered a great research, planning, management and monitoring tool. Medium to high resolution images (HyMap 2005 and Quickbird 2007 respectively) were processed and classified in order to test and compare their accuracy in producing a marine habitat map. Manta tow surveys were performed in the field for identification of 7 marine habitats 1. Coral community; 2. Coral reef; 3. Bed rock; 4. Sand; 5. Sand with boulders; 6. Sand with rodolyths; and 7. Deep water. The overall accuracy was slightly higher using Quickbird (87%) than using Hymap (60%), however the difference was not significant. The map produced using Quickbird was selected to represent the marine habitats of Isla del Caño. This map will help to analyze the adequate size and zoning of the marine protected area. PMID:20411729

Fonseca, A C; Guzmán, Héctor M; Cortés, Jorge; Soto, Carlomagno




PubMed Central

Resumen A partir de un relevamiento de tipo etnográfico, se describen lugares de encuentro de HSH en la Ciudad de Buenos Aires y sus prácticas sexuales. El reconocimiento de tales espacios, así como las características que asumen en ellos los encuentros sexuales entre los HSH, plantean obstáculos específicos en la adopción de comportamientos preventivos y, asimismo, generan nuevos desafíos para las actividades de prevención. Se plantean las dificultades y debates conceptuales que la misma categoría presenta, y sus consecuencias en el abordaje preventivo y teórico-metodológico para las ciencias sociales. Además, se proponen nuevos interrogantes acerca de los alcances y las limitaciones del modelo preventivo del VIH/Sida para HSH.

Barreda, Victoria; Carballo-Dieguez, Alex; Marone, Ruben; Balan, Ivan; Pando, Maria Angeles; Avila, Maria Mercedes



Genetic drift of marker Y chromosome del(Y)(q12) in Khanty from the lower Ob river.  


A cytogenetic study of Khanty from the lower Ob river in West Siberia has detected a high frequency of the Y chromosome heterochromatin subtotal deletion--del(Y)(q12). This morphologically identical deletion was found in 32 of 154 males examined (20.8%). The carriers had 10 different surnames. Taking into account the small size, isolation by distance, and historical peculiarities of the surname formation of the population, it has been concluded that the high frequency of the del(Y)(q12) results from the genetic drift of the marker chromosome. PMID:3862644

Nazarenko, S A; Puzyrev, V P



The Last Glacial Maximum and Termination in the Torres del Paine Region, Southern South America  

NASA Astrophysics Data System (ADS)

Deciphering the timing, structure and termination of the local last glacial maximum (LGM) throughout Patagonia (42-55 S) remains one of the key unsolved paleoclimate questions in Quaternary sciences. During the last glaciation, the Patagonian ice sheet formed one ice body along the Patagonian Andes (42-55 S) in southern South America, but previous work has revealed different spatiotemporal ice dynamics along the eastern and western ice margins. The Patagonian Andes is the only landmass that exists at this latitude confronting the southern westerly wind belt, which seems to have played a key role in past glacial and climate changes. Therefore, reconstructing southern Andes glacier history constitutes a key element for understanding the causes of glaciations in the Southern Hemisphere. Major progress has been made to document the local Late-Pleistocene glacier history, particularly in response to recent application of exposure-cosmogenic dating technique in the region, although only sparse well-dated paleoclimate records exist in this vast area. LGM moraine-based records in south Patagonia (~48-55 S) have been developed for the Strait of Magellan area, where full glacial conditions seems to have occurred between ~28.0 - 17.5 ka. Despite that these data seem to confirm previous glacial chronologies developed in north Patagonia and the Chilean Lake District (40-42 S), recent works in Torres del Paine and Última Esperanza basins (50-51 S), suggest that glacial maximum conditions may have occurred earlier (i.e., during Marine Isotope Stage 3) and that ice extent could have been twice the size of previously thought. Here, we discuss paleoclimatological implications from our 10Be and 26Al-dating program of moraines in the Torres del Paine region in southern Patagonia. We focused our efforts in the previously undated Río de las Viscachas (RV) I and II moraines, which occur distal to the late-glacial TDP II, III and IV moraines that enclose present lake bodies at the Torres del Paine National Park (e.g., Lagos del Toro, Sarmiento and Azul). RV moraines parallel each other and can be tracked continuously for several km along the southern slope of Sierra Contreras in Chile. To the east, in present day Argentina, they constitute concentric wide moraine arcs that include tens of frontal moraine ridges. We collected boulders embedded in the relatively sharp RV I and II moraines for 10Be and 26Al cosmogenic-exposure dating to reconstruct the last glacial period. We also sampled and dated cobbles from the main glaciofluvial plain grading to the outer RV I landforms, to crosscheck with the cosmogenic ages obtained from boulders embedded at moraine tops. Additionally, we present new 10Be cosmogenic ages from boulders in TDP I and TDP IV moraines at Lago del Toro basin, which help us to define the structure of the local termination.

Garcia, J.; Hall, B. L.; Kaplan, M. R.; Vega, R. M.; Binnie, S.; Gómez, G.; Santana, F.




Microsoft Academic Search

El objetivo de esta investigación fue determinar si las disposiciones fiscales del artículo 215 de la Ley del Impuesto sobre la Renta (LISR), sobre precios de transferencia a las empresas partes relacionadas, a las cuales les indica que deberán apegarse a la Guía de la Organización para la Cooperación y el Desarrollo Económico (OCDE), violentan los principios de constitucionalidad, legalidad

Martha Luisa Puente Esparza; J. Humberto González Álvarez



Análisis multinivel de cadenas de suministros: dos técnicas de resolución del efecto bullwhip \\/\\/ Supply Chain Multilevel Analysis: Two Bullwhip Dampening Approaches  

Microsoft Academic Search

El efecto bullwhip es un fenómeno causante de ineficiencias en la gestión de la cadena de suministros. El objetivo del presente artículo es analizar el impacto sobre el rendimiento de una cadena de suministro de dos de las técnicas más comunes de resolución del efecto bullwhip: la regla de pedido (S, R) amortiguada y la adopción de prácticas de colaboración.

Elena Ciancimino; Salvatore Cannella; José David Canca Ortiz; José Manuel Framiñán Torres



Geology and radiocarbon ages of Tláloc, Tlacotenco, Cuauhtzin, Hijo del Cuauhtzin, Teuhtli, and Ocusacayo monogenetic volcanoes in the central part of the Sierra Chichinautzin, México  

Microsoft Academic Search

Tláloc, Tlacotenco, Cuauhtzin, Hijo del Cuauhtzin, Teuhtli, and Ocusacayo monogenetic volcanoes located within the Sierra del Chichinautzin Volcanic Field (SCVF) at the southern margin of Mexico City were studied to further refine attendant volcanic hazards in this heavily populated region. Based on fieldwork and Landsat imagery interpretation, a geologic map was produced, morphometric parameters characterizing the cones and lava flows

Claus Siebe; Lilia Arana-Salinas; Michael Abrams



La doctora Amelie Ramírez ayuda a dirigir la investigación de las desigualdades en la atención del cáncer en la comunidad latina

La doctora Ramírez es la investigadora principal de Redes en Acción, un centro del programa de redes comunitarias subvencionado por el NCI que se propone reducir la incidencia del cáncer en la comunidad latina a través de una red nacional de grupos comunitarios, investigadores, agencias de salud gubernamentales y la población en general.


Atypical E2F transcriptional repressor DEL1 acts at the intersection of plant growth and immunity by controlling the hormone salicylic acid.  


In plants, the activation of immunity is often inversely correlated with growth. Mechanisms that control plant growth in the context of pathogen challenge and immunity are unclear. Investigating Arabidopsis infection with the powdery mildew fungus, we find that the Arabidopsis atypical E2F DEL1, a transcriptional repressor known to promote cell proliferation, represses accumulation of the hormone salicylic acid (SA), an established regulator of plant immunity. DEL1-deficient plants are more resistant to pathogens and slightly smaller than wild-type. The resistance and size phenotypes of DEL1-deficient plants are due to the induction of SA and activation of immunity in the absence of pathogen challenge. Moreover, Enhanced Disease Susceptibility 5 (EDS5), a SA transporter required for elevated SA and immunity, is a direct repressed target of DEL1. Together, these findings indicate that DEL1 control of SA levels contributes to regulating the balance between growth and immunity in developing leaves. PMID:24721578

Chandran, Divya; Rickert, Joshua; Huang, Yingxiang; Steinwand, Michael A; Marr, Sharon K; Wildermuth, Mary C




Microsoft Academic Search

La presente memoria affronta il problema dell'applicazione ad una Azienda Sanitaria del Decreto Ministeriale del 6 febbraio 2004, emanato dalla Direzione Generale per i Beni Architettonici ed il Paesaggio di concerto con l'Agenzia del Demanio, che obbliga le pubbliche Amministrazioni a sottoporre alla verifica dell'interesse culturale i propri beni immobili. Il riconoscimento di interesse storico-artistico, secondo l'Art.12 del D. Lgs

L. Alberani; G. Cervato; M. Speciale; S. Mazzacane


Relación entre los niveles de carga viral y los niveles de linfocitos CD4 en el diagnóstico de Cryptosporidium spp. en heces de niños de la Clínica Pediátrica de VIH\\/SIDA del Hospital Universitario del Valle, Cali, Colombia  

Microsoft Academic Search

SUMMARY Introduction: Cryptosporidium spp. (C. spp.) cause morbi-mortality in children with AIDS. Objective: To identify the association between viral load, CD4 levels and C. spp., presence in feces of children with AIDS. Materials and methods: Observacional study in children of the Hospital Universitario del Valle of Cali. Data like age, gender, origin, consanguinity, treatment, stage, maternal survival and weight, were




Gestión del conocimiento y desarrollo rural Enseñanzas a partir del estudio de caso de una empresa familiar innovadora y socialmente responsable en la producción orgánica de leche y lácteos en México  

Microsoft Academic Search

En la actualidad, la producción y transformación de alimentos son actividades en las que se articulan estrategias locales y globales. De frente a la sociedad del conocimiento, se requiere la incorporación de conocimiento en la generación de valor, en particular el conocimiento introducido mediante la gestión que desempeñan las empresas en su relación con instituciones de investigación y educación superior

Maria del Carmen del Valle Rivera



Reduced Blood Pressure of CFTR-F508del Carriers Correlates with Diminished Arterial Reactivity Rather than Circulating Blood Volume in Mice  

PubMed Central

The F508del mutation of the cystic fibrosis transmembrane conductance regulator (CFTR) is the most common cause of cystic fibrosis (CF). Both CF patients and F508del carriers have decreased blood pressure. While this has been attributed to salt depletion, recent studies have shown F508del expression interferes with smooth muscle cell calcium mobilization. We tested the hypothesis that carriers of the F508del mutation have lower adult blood pressures and reduced aortic contractility without a reduction in circulating blood volume. By radiotelemetry, F508del heterozygous mice had significantly lower arterial pressures than wild-type C57BL/6 controls, with the greatest effect seen at the time of dark-to-light cycle transition (mean difference of 10 mmHg). To replicate the vascular effects of sympathetic arousal, isoproterenol and epinephrine were co-infused, and F508del mice again had significantly reduced arterial pressures. Aortas isolated from F508del heterozygous mice had significantly decreased constriction to noradrenaline (0.9±0.2 versus 2.9±0.7 mN). Inhibition of wild-type CFTR or the inositol triphosphate receptor replicated the phenotype of F508del aortas. CFTR carrier status did not alter circulating blood volume. We conclude the CFTR-F508del mutation decreases aortic contractility and lowers arterial pressures. As a cAMP-activated chloride channel that facilitates calcium mobilization, we speculate wild-type CFTR co-activation during adrenergic receptor stimulation buffers the vasodilatory response to catecholamines, and loss of this compensatory vasoconstrictor tone may contribute to the lower arterial pressures seen in heterozygote carriers of a CFTR-F508del mutation.

Peotta, Veronica A.; Bhandary, Prasad; Ogu, Ugochi; Volk, Kenneth A.; Roghair, Robert D.



Structure of Mesita del Buey at TA-54, Los Alamos National Laboratory, New Mexico  

SciTech Connect

The geological structure of Mesita del Buey at Technical Area 54 (TA-54) was examined using precise surveying of the contact between units 1v and 2 of the Tshirege Member of the Bandelier Tuff at 3.5 km along the north wall of Pajarito Canyon and 0.6 km along the north wall of a tributary to Canada del Buey. Estimated structure contours on this contact indicate typical strikes of N40E to N70E along this part of Mesita del Buey, although the apparent strike of the tuff is E-W at the western part of the survey. Typical dips are 1.0{degree} to 2.0{degree} to the east or southeast, with an estimated maximum dip of 3.2{degree} near the west end of Material Disposal Area G. Thirty seven faults with vertical displacements of 5 to 65 cm were observed in outcrop along the Pajarito Canyon traverse, and, due to the incomplete exposure of the unit 1v-unit 2 contact, many more faults of this magnitude undoubtedly exist. The faults have a wide range in strike and have either down-to-the-west and down-to-the-east components of offset, although about 65% of the observed displacement is down-to-the-west or northwest. These faults are not clearly associated with major fault zones, indicated by the general absence of larger-scale offsets or inflections along the unit 1v-unit 2 contact in areas where the small-scale faults were observed; they may instead record distributed secondary deformation across the Pajarito Plateau associated with large earthquakes on the main Pajarito fault zone 8--11 km to the west, or perhaps other faults in the region. The survey data also suggest that a 150--250 m wide zone of greater magnitude faulting is present near the west end of the traverse associated with a horst-and-graben structure displaying about 1.5--3.5 m of offset on individual faults, although the total amount of offset across this structure and its orientation are not known.

Reneau, S.L.; Broxton, D.E.; Carney, J.S.; LaDelfe, C.



Ground-water exploration in the Bosque del Apache Grant, Socorro County, New Mexico  

USGS Publications Warehouse

Test drilling along the Rio Grande in the Bosque del Apache Grant in Socorro County, New Mexico has shown that the area is hydrologically complex and that the quality of the ground water varies from saline to fresh within short distances both laterally and vertically. Nearly all of the riverside land in the Grant is occupied by the migratory waterfowl refuge of the Bosque del Apache National Wildlife Refuge. Potable and near-potable water is obtained from 12 wells in this area that tap sand and gravel, and the wells are capable of yielding 1,000 gallons per minute or more. Stallion Range Center, a military installation on the White Sands Missile Range, about 15 miles east of =he waterfowl refuge, needs about 100,000 gallons per day of potable water. Potable water in large quantities is not known to be available at a location closer to the Center than the refuge area. The Fish and Wildlife Service, which operates the waterfowl refuge, gave permission to White Sands Missile Range to test drill and to develop a supply well in certain areas along the Rio Grande outside the managed lands of the refuge. The U.S. Geological Survey was then asked by White Sands Missile Range to choose locations for test drilling and to monitor drilling and testing of the wells. Between 1963 and 1967 test wells were drilled and a suitable location for a supply well as found. The well would be about 250 feet deep and would tap a body of potable water that is about 100 feet in thickness and is thought to underlie an area of at least 5 square miles. This report contains diagrammatic sections that show the lateral and vertical relation of waters of different quality along the Rio Grande in a part of the Bosque del Apache Grant. Basic data are given in tables; they include records of 7 test wells and 12 high-yield supply wells, and 52 chemical analyses of ground water from the wells.

Cooper, James B.




Microsoft Academic Search

Se plantea en el presente trabajo la utilidad de estudiar la datación del papel R. Romaní, al ser el más utilizado en la composición y copia musical en el último cuarto del siglo XVIII español. Tras plantear las condiciones que dicho estudio debería observar, se muestran los resultados de la investigación desarrollada en el Archivo del Palacio Real de Madrid,

Germán Labrador López de Azcona



Polimorfismos genéticos de aislamientos del género Malassezia obtenidos en Colombia de pacientes con lesión dermatológica y sin ella  

Microsoft Academic Search

Introducción. Las especies del género Malassezia se consideran levaduras oportunistas emergentes de gran importancia. Han sido asociadas a diferentes patologías dermatológicas y sistémicas de las cuales se aislan una o más especies de este género. El papel de estas levaduras en las enfermedades dermatológicas no se ha aclarado completamente, ya que la Malassezia spp. pertenece a la flora normal de

Adriana M. Celis; Maria Caridad Cepero de García


Genetic Variation and Chromosomal Mosaicism in the Natural Populations of Balanites aegyptiaca (L.) Del. from Rajasthan, India  

Microsoft Academic Search

Meiotic investigations were carried out in four different accessions of Balanites aegyptiaca (L.) Del. collected from various parts of Rajasthan, India. Chromosome associations, chiasma analysis and distinct pattern of chromosome\\/chromatids at anaphase I and II were studied in detail. The study revealed that all the accessions had the gametic chromosome number, except one (B. aegyptiaca BSJO-25160) that had n =

Hardev Ram; Arun Kumar; Santosh K. Sharma; Satyawada Rama Rao



Comparación de resultados del método de clasificación de órbitas por análisis de frecuencias con el método de exponentes de Lyapunov  

NASA Astrophysics Data System (ADS)

Hemos realizado extensas comparaciones del método de análisis de frecuencias con el de exponentes de Lyapunov. El primero resulta claramente superior por las siguientes razones: 1) permite distinguir distintos tipos de órbitas y no sólo si son regulares o caóticas 2) es mucho más veloz requiriendo mucho menos tiempo de cómputo. La concordancia de resultados es, en general, buena y se discuten algunas discrepancias.

Carpintero, D. D.; Muzzio, J. C.; Wachlin, F. C.



Microsoft Academic Search

Recently discovered fossil flowers from the Cretaceous Cerro del Pueblo and flowers and fruits from the Oligocene Coatzingo Formations are assigned to the Rhamnaceae. The Cretaceous flower, Coahuilanthus belindae Calvillo-Canadell and Cevallos- Ferriz, gen. et sp. nov., is actinomorphic with fused perianth parts forming a slightly campanulate to cupulate floral cup, with sepals slightly keeled and spatulate clawed petals. The



Caos en el mercado cambiario mexicano. Aplicación de la teoría del caos en los tipos de cambio  

Microsoft Academic Search

El presente trabajo estudia la dinámica cambiaria en México bajo el enfoque de una metodología poco conocida: la Teoría del Caos o, en términos de nuestra ciencia, la Economía Dinámica Caótica. Dado lo relativamente reciente de esta metodología, se presentará de manera clara y lo más rigurosamente posible sus bases teóricas, metodologías y campos de aplicación reciente; lo cual permitirá

Julián Ibarra Onofre



La restricción intertemporal del presupuesto. Una evaluación empírica para el Gobierno Nacional Central de Colombia, 1950-2010  

Microsoft Academic Search

En este documento se analiza la sostenibilidad fiscal del Gobierno Nacional Central en Colombia utilizando el enfoque de la Restricción Intertemporal de Presupuesto. Los resultados empíricos revelan que la estrategia fiscal actual es sostenible. No obstante, se vislumbran problemas de insolvencia en el largo plazo, lo que implica generar un mayor superávit primario en comparación con el actualmente programado. Lo

Álvaro Hernando Chaves



Monitoring the Persistence and Movement of Fenamiphos in Soils of Lily Bulb Fields in Del Norte County, 1986.  

National Technical Information Service (NTIS)

Three lily bulb fields, one in each of three areas of the Smith River Plains in Del Norte County, were monitored in 1986 for the persistence and downward movement of fenamiphos that had been applied to the fields in the fall of 1985. In two of the areas w...

D. J. Weaver V. Quan C. N. Collison N. Saini S. J. Marade



Nidificación del Gorrión moruno (Passer hispaniolensis) en nidos de Cotorra gris (Myiopsitta monachus) en Tenerife (Islas Canarias)  

Microsoft Academic Search

Es detalla la nidificació de pardals de passa en dos nius de cotorra de pit gris. No es va detectar cap agressió entre els pardals i les cotorres. Un dels nius, abandonat per les cotorres la primavera anterior, va ser completament ocupat pels pardals.

Juan Antonio Lorenzo



Primeres interaccions depredatòries del Bernat Pescaire (Ardea cinerea) sobre nius de Cotorreta de Pit Gris (Myiopsitta monachus) a Barcelona  

Microsoft Academic Search

Les poblacions silvestres de Bernat Pescaire i Cotorreta de Pit Gris han estat presents en els jardins de la ciutat de Barcelona, cohabitant sense problemes aparents des de 1974. En aquesta nota es presenten les primeres accions depredadores del Bernat Pescaire en nius de Cotorreta de Pit Gris. Vuit de les onze interaccions foren observades en nius considerats grans (més

Josep García; Xavier Tomás



Climate vs. Tectonics at the end of the World: the Lago Fagnano Sedimentary Record, Tierra del Fuego, Southernmost South America  

Microsoft Academic Search

Lacustrine sediments provide one of the best continental archives to reconstruct climate change. Additionally, many lakes are located in tectonically active regions and, therefore, their sediments also store regional tectonic events. Located at 55°S on the island of Tierra del Fuego, Lago Fagnano is the largest (~110 km long), southernmost non-ice covered lake in the world. It occupies the deepest

N. Waldmann; D. Ariztegui; F. Anselmetti; J. Austin; C. Moy; R. Dunbar; C. Recasens



On the neuronal\\/neuroblastic nature of medulloblastomas: a tribute to Pio del Rio Hortega and Moises Polak  

Microsoft Academic Search

The concept that medulloblastomas represent cerebellar neuroblastic tumours was championed by del Rio Hortega in the 1930s and was critically reappraised in the 1960s by Moises Polak. Whereas the aetiology and molecular pathogenesis of medulloblastomas remain unresolved, there is now compelling evidence in support of a fundamentally neuronal tumour phenotype. Tumour cells express in a differentiation-dependent manner a repertoire of

Christos D. Katsetos; Luis Del Valle; Agustin Legido; Jean-Pierre de Chadarévian; Elias Perentes; Sverre J. Mörk



Estado actual del pretratamiento de las intoxicaciones por agentes neuro- tóxicos de guerra con piridostigmina y otras alternativas farmacológicas  

Microsoft Academic Search

Resumen: El bromuro de piridostigmina (bromuro de 3-dimeti- laminocarboniloxi-N-metilpiridinio) se utiliza como pretrata- miento en escenarios en los que existe riesgo de utilización de agentes neurotóxicos de guerra. De hecho, este pretratamiento fue utilizado por las tropas Aliadas durante la Guerra del Golfo Pérsico. Desde su vuelta a casa muchos veteranos de esta guerra se han quejado de padecer síntomas

Pita R; Martínez-Larrañaga


Stato dell'arte della regolamentazione del verde urbano in Italia. Prima indagine sui comuni capoluogo di provincia  

Microsoft Academic Search

Riassunto Nei capoluoghi di provincia esaminati (l'84 % degli esistenti), frequenti sono le norme di diverso genere (regolamenti di settore, ordinanze sindacali, deliberazioni comunali, norme di carattere edilizio ed urbanistico) che riguardano la realizzazione e gestione del verde urbano. Mentre la diffusione di regolamenti propriamente detti risulta essere ancora inferiore al 20 %, quasi il 3\\/4 delle amministrazioni censite hanno

Giovanni Sanesi


Modello di valutazione dell'attitudine fisica del territorio per la realizzazione di impianti cedui da biomassa in Italia  

Microsoft Academic Search

Le piantagioni governate a ceduo a turno breve (short rotation forestry - SRF) rappresentano il modello di arboricoltura da legno maggiormente idoneo alla produzione di biomassa lignocellulosica da destinare a usi energetici. La limitata disponibilità di risorse e la rete sempre più complessa di relazioni che coinvolgono l'uso del territorio pon- gono l'esigenza di una attenta programmazione territoriale di questo

Riccardo Salvati; Gherardo Chirici; Piermaria Corona




Microsoft Academic Search

Resumen: Revisión bibliográfica sobre el análisis de citas como método para el estudio del uso y las necesidades de información por parte de los investigadores como usuarios de bibliotecas. Una vez comparados los estudios locales basados en las publicaciones de los usuarios potenciales de una biblioteca con los estudios de análisis de citas basados en la bibliografía circulante a nivel

Cristóbal Urbano Salido



Access to Information in Both CitaDel and FirstSearch: A Comparative Study of Dissertation Coverage.  

ERIC Educational Resources Information Center

Presents a comparative analysis of electronic access to theses and dissertations through CitaDel and FirstSearch. Highlights include the effectiveness and ease of use in providing enduser access; strengths and weaknesses of searching capabilities; coverage; pricing; and examples of direct retrieval comparison. (LRW)

Perry, Stephen; Salisbury, Lutishoor



Presence of large pumice blocks on Tierra del Fuego and South Shetland Islands shorelines, from 1962 South Sandwich Islands eruption  

Microsoft Academic Search

We report on the source of pumice found on beaches of Tierra del Fuego (Argentina) and the South Shetland Islands (Antarctica), north and south of the Drake Passage. Petrological studies, chemical analyses and experiments on this pumice indicate it is most likely from a 1962 submarine eruption in the South Sandwich Islands. Previous work stated that clockwise marine currents carried

Corina Risso; Roberto A Scasso; Alfredo Aparicio



Estudio del NCI revela que la obesidad extrema puede acortar la esperanza de vida hasta en 14 años

Los adultos con obesidad extrema tienen un mayor riesgo de morir a una edad más joven debido al cáncer y a muchas otras causas entre ellas, enfermedades cardíacas, accidentes cerebrovasculares, diabetes y enfermedades del hígado y los riñones, según los resultados de un análisis de datos de 20 estudios a gran escala realizados en personas de tres países.



Microsoft Academic Search

Gato del Sol III, was powered by a solar array of 480 Silicon mono-crystalline photovoltaic cells. Maximum Power Point trackers efficiently made use of these cells and tracked the optimal load. The cells were mounted on a fiber glass and foam core composite shell. The shell rides on a lightweight aluminum space frame chassis, which is powered by a 95%

Krishna Venkatesh Prayaga



The Opera del Vocabolario Italiano Database: Full-Text Searching Early Italian Vernacular Sources on the Web.  

ERIC Educational Resources Information Center

Introduces and describes the functions of the Opera del Vocabolario Italiano (OVI) database, a powerful Web-based, full-text, searchable electronic archive that contains early Italian vernacular texts whose composition may be dated prior to 1375. Examples are drawn from scholars in various disciplines who have employed the OVI in support of their…

DuPont, Christian




Microsoft Academic Search

Los desastres ocurridos en centros urbanos, no sólo en Colombia (sismo de 1983 en Popayán, el sismo de 1999 en el eje cafetero), sino en otros países del mundo1, han generado interés acerca de las implicaciones de las amenazas en las ciudades. Ante ello el gobierno colombiano ha expresado su preocupación a través de una serie de reformas y leyes

Alexandra Vallejo


Developing Flexible Dual Master's Degree Programs at UPAEP (Universidad Popular Autonoma del Estado de Puebla) and OSU (Oklahoma State University)  

ERIC Educational Resources Information Center

In 2006, UPAEP (Universidad Popular Autonoma del Estado de Puebla) and OSU (Oklahoma State University) signed a MOU (memorandum of understanding) to develop more than 20 dual master's degree programs. This special partnership has allowed students from Mexico and the United States to study two master degree programs, in two languages, in two…

Fabregas-Janeiro, Maria G.; de la Parra, Pablo Nuno



Velafrons coahuilensis, a new lambeosaurine hadrosaurid (Dinosauria: Ornithopoda) from the late Campanian Cerro del Pueblo Formation, Coahuila, Mexico  

Microsoft Academic Search

A new lambeosaurine hadrosaurid, Velafrons coahuilensis, is described as the first lambeosaurine from the Cerro del Pueblo Formation of Coahuila, Mexico, and the first lambeosaurine genus to be named from North America in more than 70 years. Although the holotype specimen is a juvenile individual—as evidenced by its incomplete crest development and relative size compared to other North American lambeosaurines—ontogeny

Terry A. Gates; Scott D. Sampson; Carlos R. Delgado De Jesús; Lindsay E. Zanno; David Eberth; René Hernandez-Rivera; Martha C. Aguillón Martínez; James I. Kirkland



Description of the Earliest Fossil Penguin from South America and First Paleogene Vertebrate Locality of Tierra Del Fuego, Argentina  

Microsoft Academic Search

We report the discovery of the first vertebrate from the Paleogene of Tierra del Fuego (Isla Grande), Argentina, in southernmost South America. The specimen consists of parts of an associated pelvic girdle and limb that are identified as belonging to the penguin stem clade (Aves: Pansphenisciformes). The specimen, from an exposure of the Leticia Formation (late middle Eocene), is the




El fracaso de la derecha en México. El comportamiento electoral del Partido Acción Nacional (PAN) y su llegada al poder  

Microsoft Academic Search

El ascenso al poder en el año 2000 de la derecha en México, representada por el PAN, fue resultado de una larga lucha contra el partido del antiguo régimen (Partido Revolucionario Institucional, PRI) y enmarcada dentro de los cauces legales (participación en procesos electorales) Una vez que el PAN asume el poder, su desempeño como partido en el Gobierno dejó

Manuel Zúñiga Aguilar



Reciprocal relation between GADD153 and Del-1 in regulation of salivary gland inflammation in Sjögren syndrome.  


Endoplasmic reticulum (ER) stress response is a pivotal regulator of inflammation and cell death. An integral component of ER stress-induced apoptosis is expression of growth arrest- and DNA damage-inducible protein 153 (GADD153). Further, ER stress response is implicated in leukocyte adhesion and recent studies have discovered endogenous inhibitors of leukocyte adhesion including the developmental endothelial locus-1 (Del-1). Accordingly, we tested the hypothesis that Sjögren's syndrome (SS) is associated with increased salivary gland expression of GADD153 and increased leukocyte infiltration in association with decreased Del-1 thereby contributing to inflammation and cell death. We utilized the non-obese diabetic (NOD) mice, a model of SS-like disease, in association with immunostaining and flow cytometry-based studies. Salivary glands of 14-week-old NOD mice displayed a) increased GADD153 expression, b) marked reduction in Del-1, c) inflammatory cell infiltrates including CD3+ T and CD19+ B lymphocytes as well as M1 and M2 macrophages and d) increased pro-inflammatory interleukin (IL)-17 but reduced anti-inflammatory cytokine, IL-10. These changes were accompanied with disruption of mitochondrial membrane potential and significant increase in apoptosis and necrosis of salivary gland cells of NOD than control mice. Our collective observations suggested that GADD153 directly and/or indirectly through downregulation of Del-1 contributes importantly to salivary gland inflammation and cell death. To establish the relevance of GADD153 and Del-1 for the human condition, lower lip biopsy samples of non-SS subjects and those with a diagnosis of SS were subjected to immunohistochemistry. The results show intense GADD153 immunostaining but marked reduction in Del-1 expression in biopsy samples of SS compared to non-SS subjects. Collectively, the results indicate that GADD153 regulates inflammation and cell death in salivary gland in SS. Further, Del-1 expression likely provides a mechanistic link between increased GADD153 and leukocyte infiltration and accompanying inflammation of salivary gland tissue in this condition. PMID:24060278

Baban, Babak; Liu, Jun Yao; Abdelsayed, Rafik; Mozaffari, Mahmood S



Glacial geomorphology of the Torres del Paine region (southern Patagonia): Implications for glaciation, deglaciation and paleolake history  

NASA Astrophysics Data System (ADS)

The processes affecting paleoclimate variability and Pleistocene glacial landscape development in the southern mid-latitudes remain poorly understood, in part because of the scarcity of comprehensive, well-studied records. Glacial landforms are invaluable for reconstructing past ice-sheet, climate, and associated environmental changes along the southern Andes, but there are significant spatial and temporal gaps in existing data. In this paper, we present new geomorphic and sedimentologic analyses, including surficial maps, for the Torres del Paine region (51°S, 73°W), southern South America. Our findings provide a new framework for understanding changes in the regional glacier history and Pleistocene landscape development. Glacial extent during the local last glacial maximum (LGM) remains unknown but new chronological data supported by geomorphic evidence afford evidence for a larger ice sheet at Torres del Paine than previously assumed. Deglaciation from the local LGM was underway by 17,400 ± 200 (1?) cal. yr. BP. As opposed to previous suggestions, we have found that most of the moraines fringing the lakes in the Torres del Paine national park were deposited during a late-glacial expansion that occurred between 14,100 and 12,500 cal. yr. BP. Late-glacial advances also have been documented recently for the Última Esperanza and Lago Argentino basins to the south and north of Torres del Paine, respectively, suggesting an overall regional ice response to a climate signal. The Tehuelche paleolake accompanied each of the ice-sheet fluctuations in Torres del Paine. New data document at least three main phases of this paleolake, which drained eastward to the Atlantic Ocean, while the Andes gaps were blocked with ice. During the late phase of glacial lake formation, when water levels reached 125-155 m a.s.l., the lake likely merged with paleolake Consuelo in the Última Esperanza area at the end of the last glaciation. Lake Tehuelche in Torres del Paine had drained into the Pacific Ocean by the late-glacial period, suggesting that ice southwest of Torres del Paine may have retreated back into the mountains by this time.

García, Juan-Luis; Hall, Brenda L.; Kaplan, Michael R.; Vega, Rodrigo M.; Strelin, Jorge A.



Organic materials in the wall paintings in Pompei: a case study of Insula del Centenario  

PubMed Central

Background The present research concerns the Roman wall paintings preserved at Insula del Centenario (IX, 8), the important Pompeian block situated in the Regio IX, along Via di Nola. Results The aims of this research are two: to verify the presence of lipidic and proteinaceous material to spread the pigments, and to identify organic matter in painting materials owing to previous restoration works. The samples collected from the wall paintings of different rooms have been investigated by Fourier Transform Infrared Spectroscopy (FT-IR), and Gas Chromatography/ Mass Spectrometry (GC/MS). Conclusions The analytical results show that these Roman wall paintings were realized without the use of lipidic and proteinaceous materials, supposedly in fresco technique. Moreover, it was detected that wax, egg, and animal glue were used in previous restoration works for protective purpose and to restore the wall paintings to their original brilliant colours.



Geophysical characterization of two circular structures at Bajada del Diablo (Patagonia, Argentina): Indication of impact origin  

NASA Astrophysics Data System (ADS)

An impact origin has been proposed for the circular structures found in Bajada del Diablo, Patagonia, Argentina. Taking into account its extension and the number of impact structures, Bajada del Diablo would be the largest meteoritic impact areas known on Earth, being an extremely interesting area for the research of impact events and processes. Moreover, the global distribution of known impact structures shows a surprising asymmetry. Particularly, South America has only seven described areas. It is evident that this situation is an artifact, highlighting the importance of intensifying the research in the least studied areas such as Argentina. Circular structures in Bajada del Diablo have been identified on two rock types: the Quiñelaf eruptive complex and Pampa Sastre Formation. In the first case, circular structures are placed in olivine basalts. On the other hand, Pampa Sastre Formation (late Pliocene/early Pleistocene) corresponds to conglomerate layers with basalt clasts boulder and block in size in a coarse sandy matrix. With the aim of further the investigation of the proposed impact origin for these circular structures, we carried out detailed topographic, magnetic and electromagnetic ground surveys in two circular structures ("8" and "A") found in Pampa Sastre conglomerates. Both circular structures are simple, bowl-shaped with rim diameters of 300 m and maximum depths of 10 m. They have been partially filled in by debris flows from the rims and wind-blown sands. Two preliminary magnetic profiles have also been carried out in circular structure "G" found in Quiñelaf basalts. The magnetic anomalies show a circular pattern with a slightly negative and relatively flat signal in the circular structures' bases. Furthermore in the circular structures' rims, high-amplitude, conspicuous and localized (short wavelength) anomalies are observed. Such large amplitude and short wavelength anomalies are not detected outside the circular structures. For all used frequencies, the electromagnetic profiles show lower apparent electrical conductivities in the circular structures' base, while the rims present notably higher values. Curvature attributes, analytic signal, horizontal gradient and Euler solutions were calculated for the magnetic data. 2.5D magnetic models were developed across the studied circular structures. Our results suggest that in the circular structures' bases up to 12 m of Pampa Sastre conglomerate would have been removed. On the contrary, the circular structures' rims exhibit high-amplitude, localized magnetic anomalies and higher apparent electrical conductivities, which would be related to the anomalous accumulation of basalt boulders and blocks remanently magnetized. Such high-amplitude anomalies are not present outside the surveyed circular structures. The geomorphological, geological and geophysical features of the studied circular structures can only be explained by means of an extra-terrestrial projectile impact. We conclude that, considering the results obtained to date, Bajada del Diablo should be envisaged as a focus of further research, which could provide novel information about impact events, associated processes and their evidences. Particularly, the data produced in this study could represent one of the first documented geophysical signatures of the impact of a comet nucleus on Earth.

Prezzi, Claudia B.; Orgeira, María Julia; Acevedo, Rogelio D.; Ponce, Juan Federico; Martinez, Oscar; Rabassa, Jorge O.; Corbella, Hugo; Vásquez, Carlos; González-Guillot, Mauricio; Subías, Ignacio



The DrosDel deletion collection: a Drosophila genomewide chromosomal deficiency resource.  


We describe a second-generation deficiency kit for Drosophila melanogaster composed of molecularly mapped deletions on an isogenic background, covering approximately 77% of the Release 5.1 genome. Using a previously reported collection of FRT-bearing P-element insertions, we have generated 655 new deletions and verified a set of 209 deletion-bearing fly stocks. In addition to deletions, we demonstrate how the P elements may also be used to generate a set of custom inversions and duplications, particularly useful for balancing difficult regions of the genome carrying haplo-insufficient loci. We describe a simple computational resource that facilitates selection of appropriate elements for generating custom deletions. Finally, we provide a computational resource that facilitates selection of other mapped FRT-bearing elements that, when combined with the DrosDel collection, can theoretically generate over half a million precisely mapped deletions. PMID:17720900

Ryder, Edward; Ashburner, Michael; Bautista-Llacer, Rosa; Drummond, Jenny; Webster, Jane; Johnson, Glynnis; Morley, Terri; Chan, Yuk Sang; Blows, Fiona; Coulson, Darin; Reuter, Gunter; Baisch, Heiko; Apelt, Christian; Kauk, Andreas; Rudolph, Thomas; Kube, Maria; Klimm, Melanie; Nickel, Claudia; Szidonya, Janos; Maróy, Peter; Pal, Margit; Rasmuson-Lestander, Asa; Ekström, Karin; Stocker, Hugo; Hugentobler, Christoph; Hafen, Ernst; Gubb, David; Pflugfelder, Gert; Dorner, Christian; Mechler, Bernard; Schenkel, Heide; Marhold, Joachim; Serras, Florenci; Corominas, Montserrat; Punset, Adrià; Roote, John; Russell, Steven



The efficiency of vertical drains piercing flat-lying beds at Piedra del Aguila Dam  

SciTech Connect

This paper analyzes the problem of determining the pattern of flow to expect through a sequence of flat-lying beds of varying permeability which are pierced by a series of equally spaced vertical drains. A single permeable bed is assumed to be bounded by two impermeable beds from above and below and the influence of a reduction in screen efficiency is evaluated. This work arose from design work associated with the Piedra del Aguila hydroelectric project in Argentina in which the left abutment of the dam consisted of an ancient buried river channel filled with a sequence of sand and gravel sediments of varying clay content mixed with layers of volcanic tuff. The outcome of the study is that a practical limit of intercepting 80% of the flow is feasible and that this limit depends strongly upon the efficiency of the drains. All suspected aquifer beds must be drained and drain efficiency should be monitored over time.

Cogan, J. (PB/MK Team, Dallas, TX (United States))



Pre-outburst observations of Nova Del 2013 from Pan-STARRS 1  

NASA Astrophysics Data System (ADS)

Context. Nova Delphini 2013 was identified on the 14th of August 2013 and eventually rose to be a naked eye object. Aims: We sought to study the behaviour of the object in the run-up to outburst and to compare it to the pre-outburst photometric characteristics of other novae. Methods: We searched the Pan-STARRS 1 datastore to identify pre-outburst photometry of Nova Del 2013 and identified twenty-four observations in the 1.2 years before outburst. Results: The progenitor of Nova Delphini showed variability of a few tenths of a magnitude but did not brighten significantly in comparison with archival plate photometry. We also found that the object did not vary significantly on the approximately half hour timescale between pairs of Pan-STARRS 1 observations.

Deacon, N. R.; Hoard, D. W.; Magnier, E. A.; Jadhav, Y. S.; Huber, M.; Chambers, K. C.; Flewelling, H.; Hodapp, K. W.; Kaiser, N.; Kudritzki, R. P.; Metcalfe, N.; Waters, C.



Drug use and HIV risks among migrant workers on the DelMarVa Peninsula.  


Because high rates of drug use have been documented in the migrant farm worker population, the National Institute on Drug Abuse funded the Migrant Health Study to examine HIV risk behaviors among drug-using farm workers and their sexual partners. Many of these individuals were home-based in South Florida and migrated during the work season to various points along the Eastern Migratory Stream. The focus of this paper is a description of the characteristics and behaviors of the 151 respondents contacted on the DelMarVa Peninsula during 1994 and 1995. The data indicate that drug use was widespread in this population, a significant proportion were at risk for HIV infection, and 6% were HIV positive. As a result of these findings, public health agencies on the peninsula have instituted HIV education programs in those clinics utilized by both local and transient agricultural workers. PMID:10210098

Inciardi, J A; Surratt, H L; Colón, H M; Chitwood, D D; Rivers, J E



Antimalaria Effect of the Ethanolic Stem Bark Extracts of Ficus platyphylla Del  

PubMed Central

The antimalarial effect of the ethanolic stem bark extract of Ficus platyphylla Del was evaluated against Plasmodium berghei infection in mice. Nontreated, experimental control mice died of fulminant parasitemia from day 7 to 9 post-infection but mice treated with the extract at 300?mg/kg showed markedly reduced parasitaemia bouts of 43.50% and a mean survival time of 28 days postinfection. The plant extract prevented a drastic reduction in PCV showing its efficacy in ameliorating anaemic conditions in Plasmodium berghei-infected mice. Histological examination of liver tissues of treated and untreated mice further supports the antimalaria potential of this plant. This observation validates the traditional use of this plant for the treatment of malaria.

Shittu, Isma'il; Emmanuel, Amlabu; Nok, Andrew Jonathan



Time resolved construction of a bimodal laccolith (Torres del Paine, Patagonia)  

NASA Astrophysics Data System (ADS)

Granitic and mafic magma pulses were sequentially accreted in the spectacularly exposed shallow crustal Torres del Paine laccolith, in southern Patagonia. This 12.5 Ma pluton forms a composite intrusion with a subvertical feeding system in the west and a laccolith in the east. A key unknown in the formation of sill complexes is how individual magma pulses are assembled over time and the geometry and localization of their feeding system. High resolution zircon CA-ID-TIMS U-Pb dating shows that the laccolith grew first by under-accretion of granitic sills over 90 ± 30 ka, linked to a 'sheet-like' feeding system, followed by underplating of mafic sills after ~ 20 ka of quiescence. In the mafic sills complex, individual sills were injected by over-accretion during 41 ± 11 ka. Our data show that successive granitic and mafic magmas emplacement generated a volume of ~ 88 km3 in 162 ± 11 ka.

Leuthold, Julien; Müntener, Othmar; Baumgartner, Lukas P.; Putlitz, Benita; Ovtcharova, Maria; Schaltegger, Urs




Microsoft Academic Search

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Radiogenic Xenon-129 in Silicate Inclusions in the Campo Del Cielo Iron Meteorite  

NASA Technical Reports Server (NTRS)

Iron meteorites present a challenge for the I-Xe dating technique because it is usually the inclusions, not metal, that contain radiogenic xenon and iodine. Silicate inclusions are frequent in only types IAB and IIE, and earlier studies of irons have demonstrated that I-Xe system can survive intact in these inclusions preserving valuable age information. Our previous studies of the I-Xe record in pyroxene grains from Toluca iron suggested an intriguing relationship between apparent I-Xe ages and (Mg+Fe)/Fe ratios. The I-Xe system in K-feldspar inclusions from Colomera (IIE) had the fingerprint of slow cooling, with an indicated cooling rate of 2-4 C/Ma. Here we present studies of the iodine-xenon system in a silicate-graphite-metal (SiGrMet) inclusion of the IA Campo del Cielo iron meteorite from the collection of the Museum of Natural History in Vienna.

Meshik, A.; Kurat, G.; Pravdivtseva, O.; Hohenberg, C. M.



Bajada del Diablo impact crater-strewn field: The largest crater field in the Southern Hemisphere  

NASA Astrophysics Data System (ADS)

Recent remote sensing analyses and field studies have shown that Bajada del Diablo, in Argentina, is a new crater-strewn field. Bajada del Diablo is located in a remote area of Chubut Province, Patagonia. This amazing strewn field contains more than 100 almost circular, crater-type structures with diameters ranging from 100 to 500 m in width and 30 to 50 m in depth. It is composed of three separated impact crater fields, which formed simultaneously. The impact was upon a Miocene basaltic plateau and Pliocene-Early Pleistocene pediments. The original crater field (60 km 2) was later eroded by Late Pleistocene fluvial processes; thus, three major, separate areas were defined. Due to the erosional processes that have affected the area, it is difficult to determine yet if the crater field has a classic elliptical distribution. Crater structures are similar in target rocks, although showing different response and morphology in relation to rock type. They are simple rings, bowl-shaped with raised rimrock. Basaltic boulders have been deposited as a ring-shaped pile and the ejecta are found toward the NE flanks. The craters present a hummocky bottom, with dry ponds and lakes in the center, but they do not show raised central peaks. The rocks within the craters have strong and stable magnetic signature. No meteorite fragments or other diagnostic landmarks have been found yet. The craters have been partially filled in by debris flows from the rim and windblown sands in recent times. The origin of these crater fields may be related to multiple fragmentation of one asteroid that broke up before impact, perhaps traveling across the space as a rubble pile. Alternatively, multiple collisions of comet fragments could explain the formation of these crater fields. Based on field geological and geomorphological data, the age of this event is estimated to be bracketed between Early Pleistocene and Late Pleistocene (i.e., 0.78-0.13 Ma ago).

Acevedo, R. D.; Ponce, J. F.; Rocca, M.; Rabassa, J.; Corbella, H.



Modeling the electrostatic potential of asymmetric lipopolysaccharide membranes: The MEMPOT algorithm implemented in DelPhi.  


Four chemotypes of the rough lipopolysaccharides (LPS) membrane from Pseudomonas aeruginosa were investigated by a combined approach of explicit water molecular dynamics (MD) simulations and Poisson-Boltzmann continuum electrostatics with the goal to deliver the distribution of the electrostatic potential across the membrane. For the purpose of this investigation, a new tool for modeling the electrostatic potential profile along the axis normal to the membrane, MEMbrane POTential (MEMPOT), was developed and implemented in DelPhi. Applying MEMPOT on the snapshots obtained by MD simulations, two observations were made: (a) the average electrostatic potential has a complex profile but is mostly positive inside the membrane due to the presence of Ca(2+) ions, which overcompensate for the negative potential created by lipid phosphate groups; and (b) correct modeling of the electrostatic potential profile across the membrane requires taking into account the water phase, while neglecting it (vacuum calculations) results in dramatic changes including a reversal of the sign of the potential inside the membrane. Furthermore, using DelPhi to assign different dielectric constants for different regions of the LPS membranes, it was investigated whether a single frame structure before MD simulations with appropriate dielectric constants for the lipid tails, inner, and the external leaflet regions, can deliver the same average electrostatic potential distribution as obtained from the MD-generated ensemble of structures. Indeed, this can be attained by using smaller dielectric constant for the tail and inner leaflet regions (mostly hydrophobic) than for the external leaflet region (hydrophilic) and the optimal dielectric constant values are chemotype-specific. © 2014 Wiley Periodicals, Inc. PMID:24799021

Dias, Roberta P; Li, Lin; Soares, Thereza A; Alexov, Emil



Bryophyte-Cyanobacteria Associations during Primary Succession in Recently Deglaciated Areas of Tierra del Fuego (Chile)  

PubMed Central

Bryophyte establishment represents a positive feedback process that enhances soil development in newly exposed terrain. Further, biological nitrogen (N) fixation by cyanobacteria in association with mosses can be an important supply of N to terrestrial ecosystems, however the role of these associations during post-glacial primary succession is not yet fully understood. Here, we analyzed chronosequences in front of two receding glaciers with contrasting climatic conditions (wetter vs drier) at Cordillera Darwin (Tierra del Fuego) and found that most mosses had the capacity to support an epiphytic flora of cyanobacteria and exhibited high rates of N2 fixation. Pioneer moss-cyanobacteria associations showed the highest N2 fixation rates (4.60 and 4.96 µg N g?1 bryo. d?1) very early after glacier retreat (4 and 7 years) which may help accelerate soil development under wetter conditions. In drier climate, N2 fixation on bryophyte-cyanobacteria associations was also high (0.94 and 1.42 µg N g?1 bryo. d?1) but peaked at intermediate-aged sites (26 and 66 years). N2 fixation capacity on bryophytes was primarily driven by epiphytic cyanobacteria abundance rather than community composition. Most liverworts showed low colonization and N2 fixation rates, and mosses did not exhibit consistent differences across life forms and habitat (saxicolous vs terricolous). We also found a clear relationship between cyanobacteria genera and the stages of ecological succession, but no relationship was found with host species identity. Glacier forelands in Tierra del Fuego show fast rates of soil transformation which imply large quantities of N inputs. Our results highlight the potential contribution of bryophyte-cyanobacteria associations to N accumulation during post-glacial primary succession and further describe the factors that drive N2-fixation rates in post-glacial areas with very low N deposition.

Arroniz-Crespo, Maria; Perez-Ortega, Sergio; De los Rios, Asuncion; Green, T. G. Allan; Ochoa-Hueso, Raul; Casermeiro, Miguel Angel; de la Cruz, Maria Teresa; Pintado, Ana; Palacios, David; Rozzi, Ricardo; Tysklind, Niklas; Sancho, Leopoldo G.



Decadal increase in seagrass biomass and temperature at the CARICOMP site in Bocas del Toro, Panama.  


The Caribbean Coastal Marine Productivity Program (CARICOMP) was launched in 1993 to study regional long-term interactions between land and sea, taking standardized measurements of productivity and biomass of mangroves, coral reefs and seagrasses. Since 1999 continuous measurements of seagrass (Thalassia testudinum) parameters as well as environmental data have been recorded in Caribbean Panama. Replicate stations were selected near the Smithsonian Tropical Research Institute in Bocas del Toro. Sediment cores and quadrants were placed there to estimate biomass and productivity, respectively. Mean values for productivity, standing crop, turnover rate, total dry biomass, and Leaf Area Index were 1.74 gDW/m2/d, 66.6 gDW/m2, 2.62%/d, 1481 gDW/m2, and 4.65, respectively. Total dry biomass (shoots, rhizomes and roots) and LAI of T. testudinum increased significantly during the study period. Mean values for total rainfall, Secchi disk depth, sea surface temperature, and salinity were 3498 mm, 8.24 m, 28.79 degrees C, and 32.26 psu, respectively. Sea surface temperature was the only environmental variable with a statistically significant change, increasing from 1999 to 2010. Correlation between sea surface temperature and 7 testudinum parameters (total biomass and LAI) were both positive and significant. Human population has increased dramatically over the last ten years in Bocas del Toro region, increasing pressure (deforestation, runoff, wastewater) over coastal ecosystems (seagrasses, mangroves, coral reefs). Change in the abundance of 7 testudinum may be linked to ocean warming, as a consequence to satisfy plant's metabolic requirements, although other local factors need to be analyzed (reduced grazing and increased eutrophication). A further warming of the ocean could have a negative effect on T. testudinum population, increasing respiratory demands and microbial metabolism. PMID:24432536

López-Calderón, Jorge M; Guzmán, Hector M; Jácome, Gabriel E; Barnes, Penélope A G



Numerical simulations of the Ora del Garda wind in the Alps  

NASA Astrophysics Data System (ADS)

High-resolution numerical simulations performed with the WRF model are analyzed to investigate the atmospheric boundary layer (ABL) structures associated with the development of a lake-breeze and valley-wind coupled system developing in the southeastern Italian Alps, the so-called "Ora del Garda" wind. Four nested grids are used, achieving a final horizontal resolution of 0.4 km. High-resolution orography and land use datasets are adopted for the domain initialization, while NCEP reanalysis provides initial and boundary conditions for the meteorological fields. Model results complement an existing dataset composed of a series of measurement flights, performed by means of an instrumented motorglider, and surface observations, which is also adopted to validate model results. The flights explored specific valley sections at key locations in the study area, namely over the lake's shore, at half valley and at the end of the valley where the breeze blows. Air pressure, temperature and relative humidity measurements were recorded. Model results display a good agreement with the experimental dataset. In particular, the surface diurnal cycles of radiation, wind and air temperature are satisfactorily reproduced, despite some discrepancies in the timing of thermally-driven circulation onset and offset. The typical structure of the valley ABL, characterized by shallow or even absent mixed layers surmounted by slightly stable layers extending up to the lateral crest level, is also qualitatively well reproduced in the simulated fields. Moreover, the simulations confirm characteristic local-scale features of the thermally-driven wind field suggested by the analysis of the airborne dataset as well as from previous observations in the area. For example, the model shows the development of a well-defined lake breeze front in the lake's shoreline area, as well as the formation of a hydraulic jump structure in the area where the Ora del Garda flows down into an adjacent valley from an elevated saddle.

Giovannini, Lorenzo; Laiti, Lavinia; Zardi, Dino



CDC25AQ110del: A Novel Cell Division Cycle 25A Isoform Aberrantly Expressed in Non-Small Cell Lung Cancer  

PubMed Central

Objective Lung cancer remains number one cause of cancer related deaths worldwide. Cell cycle deregulation plays a major role in the pathogenesis of Non-Small Cell Lung Cancer (NSCLC). CDC25A represents a critical cell cycle regulator that enhances cell cycle progression. In this study we aimed to investigate the role of a novel CDC25A transcriptional variant, CDC25AQ110del, on the regulation of the CDC25A protein, and its impact on prognosis of NSCLC patients. Methodology/Principal Findings Here we report a novel CDC25A transcript variant with codon 110 (Glutamine) deletion, that we termed CDC25AQ110del in NSCLC cells. In 9 (75%) of the 12 NSCLC cell lines, CDC25AQ110del expression accounted for more than 20% of the CDC25A transcripts. Biological effects of CDC25AQ110del were investigated in H1299 and HEK-293F cells using UV radiation, flowcytometry, cyclohexamide treatment, and confocal microscopy. Compared to CDC25Awt, CDC25AQ110del protein had longer half-life; cells expressing CDC25AQ110del were more resistant to UV irradiation and showed more mitotic activity. Taqman-PCR was used to quantify CDC25AQ110del expression levels in 88 primary NSCLC tumor/normal tissue pairs. In patients with NSCLC, Kaplan Meier curves showed tumors expressing higher levels of CDC25AQ110del relative to the adjacent lung tissues to have significantly inferior overall survival (P?=?.0018). Significance Here we identified CDC25AQ110del as a novel transcriptional variant of CDC25A in NSCLC. The sequence-specific nature of the abnormality could be a prognostic indicator in NSCLC patients as well as a candidate target for future therapeutic strategies.

Younis, Rania H.; Cao, Wei; Lin, Ruxian; Xia, Ronghui; Liu, Zhenqiu; Edelman, Martin J.; Mei, Yuping; Mao, Li; Ren, Hening



Filaggrin Gene Mutation c.3321delA Is Associated with Various Clinical Features of Atopic Dermatitis in the Chinese Han Population  

PubMed Central

Background We confirmed that the filaggrin gene mutation c.3321delA is associated with atopic dermatitis in our previous genome wide association study of the Chinese Han population. c.3321delA is the most common filaggrin gene mutation in Chinese atopic dermatitis patients but is not present in European populations. Objective To investigate the genetic model for the c.3321delA mutation and to determine the correlation between c.3321delA and atopic dermatitis clinical phenotypes in the Chinese Han population. Method The filaggrin gene mutation c.3321delA was sequenced in 1,080 atopic dermatitis patients and 908 controls from the Chinese population. The ?2 test, ANOVA,nonparametric tests and logistic regression were used to investigate the relationship between the c.3321delA genotype and atopic dermatitis clinical phenotypes in the Chinese Han population. Results Analyses of the genetic model revealed that the additive model best described the c.3321delA mutation (P?=?3.09E-11, OR?=?3.43, 95%CI?=?2.38–4.96). Stratified analyses showed that the c.3321delA allele frequency distribution is significantly associated with concomitant skin xerosis (P?=?1.68E-03, OR?=?2.13,95%CI?=?1.32–3.46), palmar hyperlinearity (P?=?3.64E-17, OR?=?4.0,95%CI?=?2.86–5.70), white dermatographism (P?=?4.25E-03, OR?=?1.82,95%CI?=?1.22–2.71), food intolerance (P?=?1.51E-03, OR?=?1.76,95%CI?=?1.23–2.50) and disease severity ( P?=?9.67E-05). Conclusion Our study indicates that the filaggrin gene mutation c.3321delA is associated with clinical phenotypes of atopic dermatitis in the Chinese Han population, which might help us gain a better understanding on the pathogenesis of atopic dermatitis.

Tang, Xianfa; Jiang, Xiaoyun; Zhao, Jinhua; Gao, Jing; Li, Bing; Fu, Xuhui; Chen, Yan; Yao, Weiyi; Zhan, Wenying; Wu, Bo; Duan, Dawei; Shen, Changbing; Cheng, Hui; Zuo, Xianbo; Yang, Sen; Sun, Liangdan; Zhang, Xuejun



Spatial variability of cv Tempranillo phenology within the Ribera del Duero DO (Spain) related to soil type and plot characteristics  

NASA Astrophysics Data System (ADS)

Vineyards in the Ribera del Duero area (Spain) date back to the roman time, with significant fluctuations throughout the centuries, reaching consolidation and stable production in the 10th and 11th centuries. The present Ribera del Duero Designation of Origen (DO) started in 1980 and has increased from less than 6,000 ha planted to more than 21,000 ha planted by 2010 and becoming one the top regions for wine production in Spain with success in the global wine market. Vineyards of Ribera del Duero are found along 115 km of the Duero River. Within this distance, differences in elevation and topography produce differences in climate, which provide the means by which a zonification for vineyard management can be assessed. In this work, the differences in phenological growth characteristics for the Tempranillo variety were analyzed within the Ribera del Duero DO and related to soil and plot characteristics. Phenology dates, referenced to different Baggiolini classification stages, were evaluated in 20 control plots distributed throughout the Ribera del Duero DO during the period 2004-2012. These years presented different climatic characteristics, which were analyzed from daily temperature and precipitation series recorded from 1980 to 2012 at five stations located along the Duero River. Most vineyards were cultivated under rainfed conditions. In order to evaluate the spatial variability in phenology, climate and soils, the plots were classified using a hierarchical cluster multivariate analysis. Parameters such as the elevation, the distance to river and the soil type were taken into account in the classification. According to the WRB classification (2006) the main soil types in the area are Calcaric Cambisols, Eutric Cambisols, Calcic Luvisol, Calcaric fluvisols, Eutric fluvisols and in less proportion Lithic Leptosols and Calcaric Rogosols. Four different groups were observed, with differences in elevation, distance to the Duero River and the soil type. The differences in phenology among groups started in stage G and were observed until the end of the growing cycle. Despite the high variability driven by the year to year in climate characteristics, it was possible to define the soil and plot characteristics that favour advanced phenology within the Ribera del Duero DO.

Ramos, Maria C.; Jones, Gregory V.; Yuste, Jesús



Analysis of strong rainfall events at Cividale del Friuli (Northeastern Italy) from 1920 to 2007  

NASA Astrophysics Data System (ADS)

Strong rainfall events have been selected from a detailed statistical investigation of the rainfall regime recorded at Cividale del Friuli (which is a town situated in the piedmont area of the Italian Prealpi Giulie), by applying suitable thresholds on the set of monthly and daily rainfall. On the basis of these data the following aspects as been explored: Time evolution of the location of the most rainy month, for each year, in the meteorological seasons; Return period, in years, of the maximum monthly precipitation, for each year; Return period, in years, of the maximum daily precipitation, for each year; Return period, in years, of the maximum precipitation during two consecutive days, for each year; Trend of the series of rainy days above a given thresholds, for different thresholds; Long term evolution of the infra-annual precipitation by averaging four 21-years cycles of rainfall for the periods 1924-44, 1945-65, 1966-86, 1987-2007; Comparison of the above rainfall series with that of Trieste which is a coastal town situated at the north-eastern most part of the Adriatic sea, about 70 km far from Cividale del Friuli (which is usually much more rainy than Trieste). Unlike the almost constant linear trend for Trieste, that of Cividale del Friuli is markedly decreasing in the whole period 1920-2007. This phenomenon is ascribed to a recent climatic change in the mesoscale wind regime in which winds from NW-N-NE are more frequent than those zonal. Therefore in the areas more close to the mountains a lesser and lesser quantity of rain is recorded relatively to the areas far enough from the mountains like Trieste. The different behaviour is more evident during spring and summer which are the seasons with the higher occurrence of thunderstorms. Winter period shows a different behaviour between the years before and after 1980; in the last 30 years the decreasing of the differences has been very pronounced. Further conclusions are the following: Total yearly rainfalls show a relevant decrease of about -277mm/100y; The most rainy month is July for the whole interval 1920-2007, but this month undergoes an important climatic change with the tendency to become a typical late summer month; The soul month in which rainfalls has increased is September, on the other hand January, July, October and December do not exhibit significant variations while the remaning months tend to become more dry; Total rainfall on September 1965, that is 708 mm, is quite exceptional and probably such values has a return period much longer than those analyzed in this work; The number of days with strong rainfalls (50-75 mm/d) is constant in the considered interval and this implies the tendency to less frequent but more intense rainfall events; Intense rainfall during two days take placed more frequently from Maj to June and from September to November and 17 cases have been recorded with intensity higher than 150mm/2d; In general, the return period of a rainfall with 100mm/2d is 1.5 years, of one with 150mm/2d is about 5 years and of one over 200mm/2d is beyond 30 years; The maximum rainfall that has taken placed on two consecutive days reached 210.4 mm;

Colucci, R. R.; Cucchi, F.; Stravisi, F.; Zini, L.



Rock Magnetic Properties of Laguna Carmen (Tierra del Fuego, Argentina): Implications for Paleomagnetic Reconstruction  

NASA Astrophysics Data System (ADS)

We report preliminary results obtained from a multi-proxy analysis including paleomagnetic and rock-magnetic studies of two sediment cores of Laguna Carmen (53°40'60" S 68°19'0" W, ~83m asl) in the semiarid steppe in northern Tierra del Fuego island, Southernmost Patagonia, Argentina. Two short cores (115 cm) were sampled using a Livingstone piston corer during the 2011 southern fall. Sediments are massive green clays (115 to 70 cm depth) with irregularly spaced thin sandy strata and lens. Massive yellow clay with thin sandy strata continues up to 30 cm depth; from here up to 10 cm yellow massive clays domain. The topmost 10 cm are mixed yellow and green clays with fine sand. Measurements of intensity and directions of Natural Remanent Magnetization (NRM), magnetic susceptibility, isothermal remanent magnetization, saturation isothermal remanent magnetization (SIRM), back field and anhysteretic remanent magnetization at 100 mT (ARM100mT) were performed and several associated parameters calculated (ARM100mT/k and SIRM/ ARM100mT). Also, as a first estimate of relative magnetic grain-size variations, the median destructive field of the NRM (MDFNRM), was determined. Additionally, we present results of magnetic parameters measured with vibrating sample magnetometer (VSM). The stability of the NRM was analyzed by alternating field demagnetization. The magnetic properties have shown variable values, showing changes in both grain size and concentration of magnetic minerals. It was found that the main carrier of remanence is magnetite with the presence of hematite in very low percentages. This is the first paleomagnetic study performed in lakes located in the northern, semiarid fuegian steppe, where humid-dry cycles have been interpreted all along the Holocene from an aeolian paleosoil sequence (Orgeira et el, 2012). Comparison between paleomagnetic records of Laguna Carmen and results obtained in earlier studies carried out at Laguna Potrok Aike (Gogorza et al., 2012) were performed. References Gogorza, C.S.G., Irurzun, M.A., Sinito, A.M., Lisé-Pronovost, A., St-Onge, G., Haberzettl, T., Ohlendorf, C., Kastner, S., Zolitschka, B., 2012. High-resolution paleomagnetic records from Laguna Potrok Aike (Patagonia, Argentina) for the last 16,000 years. Geochemistry Geophysics Geosystems. 13, Q12Z37. Orgeira, M.J., Vásquez, C.A., Coronato, A., Ponce, F., Moreto, A., Osterrieth, M, Egli, R., Onorato, R., 2012. Magnetic properties of Holocene edaphized silty eolian sediments from Tierra del Fuego (Argentina). Revista de la Sociedad Geológica de España. 25 (1-2), 45-56.

Gogorza, C. G.; Orgeira, M. J.; Ponce, F.; Fernández, M.; Laprida, C.; Coronato, A.



Assessing the ecological effects of human impacts on coral reefs in Bocas del Toro, Panama.  


Environmental and biological reef monitoring was conducted in Almirante Bay (Bahía Almirante) in Bocas del Toro, Panama, to assess impacts from anthropogenic developments. An integrated monitoring investigated how seasonal temperature stress, turbidity, eutrophication and physical impacts threatened reef health and biodiversity throughout the region. Environmental parameters such as total suspended solids [TSS], carbon isotopes (?(13)C), C/N ratios, chlorophyll a, irradiance, secchi depth, size fractions of the sediments and isotope composition of dissolved inorganic carbon [DIC] of the water were measured throughout the years 2010 and 2011 and were analysed in order to identify different impact sources. Compared to data from Collin et al. (Smithsonian Contributions to the Marine Sciences 38:324-334, 2009) chlorophyll a has doubled at sites close to the city and the port Almirante (from 0.46-0.49 to 0.78-0.97 ?g l(-1)) and suspension load increased, visible by a decrease in secchi depth values. Visibility decreased from 9-13 m down to 4 m at the bay inlet Boca del Drago, which is strongly exposed to river run off and dredging for the shipping traffic. Eutrophication and turbidity levels seemed to be the determining factor for the loss of hard coral diversity, most significant at chlorophyll a levels higher than 0.5 ?g l(-1) and TSS levels higher than 4.7 mg l(-1). Hard coral cover within the bay has also declined, at some sites down to <10 % with extremely low diversities (7 hard coral species). The hard coral species Porites furcata dominated the reefs in highly impacted areas and showed a strong recovery after bleaching and a higher tolerance to turbidity and eutrophication compared to other hard coral species in the bay. Serious overfishing was detected in the region by a lack of adult and carnivorous fish species, such as grunts, snappers and groupers. Study sites less impacted by anthropogenic activities and/or those with local protection showed a higher hard coral cover and fish abundance; however, an overall loss of hard coral diversity was observed. PMID:24254491

Seemann, Janina; González, Cindy T; Carballo-Bolaños, Rodrigo; Berry, Kathryn; Heiss, Georg A; Struck, Ulrich; Leinfelder, Reinhold R



CHEK2*1100delC does not contribute to risk to breast cancer among Malay, Chinese and Indians in Malaysia.  


A truncating mutation (1100delC) in the cell cycle checkpoint kinase-2 gene, CHEK2, has been identified as a risk factor for familial and sporadic breast cancer in some Northern and Western European populations. However, the prevalence of CHEK2*1100delC in breast cancer appears to be population dependent. We analysed the prevalence of CHEK2*1100delC in 668 breast cancer cases, of which 542 were invasive breast cancers, from a hospital-based cohort of breast cancer patients from Kuala Lumpur, Malaysia. The variant was not found in any patients in this cohort, suggesting that CHEK2*1100delC is rare in our population, and unlikely to contribute significantly to risk to breast cancer among the Malay, Chinese and Indian ethnic groups in Malaysia. This suggests that screening for this allele should not be routinely conducted in Malaysia. PMID:19399639

Thirthagiri, Eswary; Cheong, Leng San; Yip, Cheng Har; Teo, Soo-Hwang



Meeting of the International Society for Neurochemistry (10th) Held at Riva del Garda, Italy on 19-24 May 1985.  

National Technical Information Service (NTIS)

The Tenth Meeting of the International Society for Neurochemistry was held in Riva del Garda, Italy, from 19 through 24 May 1985. This report discusses presentations on molecular neurobiology, post-translational modification, neurotransmitter receptors, n...

C. E. Zomzely-Neurath



Anticipating and training for the worst-case metabolic scenario: a comment on Del Vecchio, Hirata, and Franchini (2011).  


Del Vecchio, Hirata, and Franchini (2011) studied the effort: pause ratio of mixed martial arts by analyzing 26 bouts in two separate mixed martial arts events in Sao Paulo, Brazil. They referenced research identifying effort:pause ratios from other combat sports ranging from 10:1 (Brazilian Jiu Jitsu), 2:1 (judo and wrestling), and 1:3/1:4 (taekwondo). The authors identified an effort:pause ratio ranging from 1:2 to 1:4 in the bouts they analyzed, and suggested and described training programs that resemble this ratio. It is important for coaches to anticipate the most challenging metabolic mixed martial arts scenario and to create training programs that mimic that profile. Del Vecchio and associates' research is an important first step in gathering information which can help enhance training programs for injury prevention and performance enhancement. PMID:22582681

Amtmann, John



Analysis of density and epitopes of D antigen on the surface of erythrocytes from DEL phenotypic individuals carrying the RHD1227A allele  

PubMed Central

Background The characteristics of the D antigen are important as they influence the immunogenicity of D variant cells. Several studies on antigenic sites have been reported in normal D positive, weak D and partial D cases, including a comprehensive analysis of DEL types in Caucasians. The aim of this study was to assess D antigen density and epitopes on the erythrocyte surface of Asian type DEL phenotypic individuals carrying the RHD1227A allele in the Chinese population. Materials and methods A total of 154 DEL phenotypic individuals carrying the RHD1227A allele were identified through adsorption and elution tests and polymerase chain reaction analysis with sequence-specific primers in the Chinese population. D antigen density on the erythrocyte surface of these individuals was detected using a flow cytometric method. An erythrocyte sample with known D antigen density was used as a standard. Blood samples from D-negative and D-positive individuals were used as controls. In addition, D antigen epitopes on the erythrocyte surface of DEL individuals carrying the RHD1227A allele were investigated with 18 monoclonal anti-D antibodies specific for different D antigen epitopes. Results The means of the median fluorescence intensity of D antigen on the erythrocyte membrane surface of D-negative, D-positive and DEL individuals were 2.14±0.25, 193.61±11.43 and 2.45±0.82, respectively. The DEL samples were estimated to have approximately 22 D antigens per cell. The samples from all 154 DEL individuals reacted positively with 18 monoclonal anti-D antibodies specific for different D antigen epitopes. Discussion In this study, D antigen density on the erythrocyte surface of DEL individuals carrying the RHD1227A allele was extremely low, there being only very few antigenic molecules per cell, but the D antigen epitopes were grossly complete.

Gu, Juan; Sun, An-Yuan; Wang, Xue-Dong; Shao, Chao-Peng; Li, Zheng; Huang, Li-Hua; Pan, Zhao-Lin; Wang, Qing-Ping; Sun, Guang-Ming



The CF-modifying gene EHF promotes p.Phe508del-CFTR residual function by altering protein glycosylation and trafficking in epithelial cells  

PubMed Central

The three-base-pair deletion c.1521_1523delCTT (p.Phe508del, F508del) in the cystic fibrosis transmembrane conductance regulator (CFTR) is the most frequent disease-causing lesion in cystic fibrosis (CF). The CFTR gene encodes a chloride and bicarbonate channel at the apical membrane of epithelial cells. Altered ion transport of CFTR-expressing epithelia can be used to differentiate manifestations of the so-called CF basic defect. Recently, an 11p13 region has been described as a CF modifier by the North American CF Genetic Modifier Study Consortium. Selecting the epithelial-specific transcription factor EHF (ets homologous factor) as the likely candidate gene on 11p13, we have genotyped two intragenic microsatellites in EHF to replicate the 11p13 finding in the patient cohort of the European CF Twin and Sibling Study. We could observe an association of rare EHF haplotypes among homozygotes for c.1521_1523delCTT in CFTR, which exhibit a CF-untypical manifestation of the CF basic defect such as CFTR-mediated residual chloride secretion and low response to amiloride. We have reviewed transcriptome data obtained from intestinal epithelial samples of homozygotes for c.1521_1523delCTT in CFTR, which were stratified for their EHF genetic background. Transcripts that were upregulated among homozygotes for c.1521_1523delCTT in CFTR, who carry two rare EHF alleles, were enriched for genes that alter protein glycosylation and trafficking, both mechanisms being pivotal for the effective targeting of fully functional p.Phe508del-CFTR to the apical membrane of epithelial cells. We conclude that EHF modifies the CF phenotype by altering capabilities of the epithelial cell to correctly process the folding and trafficking of mutant p.Phe508del-CFTR.

Stanke, Frauke; van Barneveld, Andrea; Hedtfeld, Silke; Wolfl, Stefan; Becker, Tim; Tummler, Burkhard



Comparison CCR5del32 Mutation in the CCR5 Gene Frequencies in Russians, Tuvinians, and in Groups of HIV-Infected Individuals  

Microsoft Academic Search

The 32-bp deletion (CCR5del32 mutation) in the CCR5 (chemokine (C-C motif) receptor 5) gene, encoding CCR5 chemokine receptor, is one of the factors determining natural resistance\\u000a to human immunodeficiency virus (HIV-1) infection. In the present study, the samples of Russians (n = 102), Tuvinians (n = 50), and HIV-infected individuals (n = 107) were examined for the presence of CCR5del32

S. A. Apryatin; E. R. Rakhmanaliev; I. A. Nikolaeva; S. V. Ruban; F. G. Vazykhova; E. A. Klimov; G. E. Sulimova; I. G. Sidorovich



Efficient indica and japonica rice identification based on the InDel molecular method: Its implication in rice breeding and evolutionary research  

Microsoft Academic Search

An efficient molecular method for the accurate and efficient identification of indica and japonica rice was created based on the polymorphisms of insertion\\/deletion (InDel) DNA fragments obtained from the basic local alignment search tool (BLAST) to the entire genomic sequences of indica (93-11) and japonica rice (Nipponbare). The 45 InDel loci were validated experimentally by the polymerase chain reaction (PCR)

Bao-Rong Lu; Xingxing Cai; Jin Xin



Phospholamban R14del mutation in patients diagnosed with dilated cardiomyopathy or arrhythmogenic right ventricular cardiomyopathy: evidence supporting the concept of arrhythmogenic cardiomyopathy  

PubMed Central

Aims To investigate whether phospholamban gene (PLN) mutations underlie patients diagnosed with either arrhythmogenic right ventricular cardiomyopathy (ARVC) or idiopathic dilated cardiomyopathy (DCM). Methods and results We screened a cohort of 97 ARVC and 257 DCM unrelated index patients for PLN mutations and evaluated their clinical characteristics. PLN mutation R14del was identified in 12 (12 % ) ARVC patients and in 39 (15 % ) DCM patients. Haplotype analysis revealed a common founder, estimated to be between 575 and 825 years old. A low voltage electrocardiogram was present in 46 % of R14del carriers. Compared with R14del– DCM patients, R14del+ DCM patients more often demonstrated appropriate implantable cardioverter defibrillator discharge (47 % vs. 10 % , P < 0.001), cardiac transplantation (18 % vs. 2 % , P < 0.001), and a family history for sudden cardiac death (SCD) at < 50 years (36 % vs. 16 % , P = 0.007). We observed a similar pattern in the ARVC patients although this was not statistically significant. The average age of 26 family members who died of SCD was 37.7 years. Immunohistochemistry in available myocardial samples revealed absent/depressed plakoglobin levels at intercalated disks in five of seven (71 % ) R14del+ ARVC samples, but in only one of nine (11 % ) R14del+ DCM samples (P = 0.03). Conclusions The PLN R14del founder mutation is present in a substantial number of patients clinically diagnosed with DCM or ARVC. R14del+ patients diagnosed with DCM showed an arrhythmogenic phenotype, and SCD at young age can be the presenting symptom. These findings support the concept of ‘arrhythmogenic cardiomyopathy’.

van der Zwaag, Paul A.; van Rijsingen, Ingrid A.W.; Asimaki, Angeliki; Jongbloed, Jan D.H.; van Veldhuisen, Dirk J.; Wiesfeld, Ans C.P.; Cox, Moniek G.P.J.; van Lochem, Laura T.; de Boer, Rudolf A.; Hofstra, Robert M.W.; Christiaans, Imke; van Spaendonck-Zwarts, Karin Y.; Lekanne dit Deprez, Ronald H.; Judge, Daniel P.; Calkins, Hugh; Suurmeijer, Albert J.H.; Hauer, Richard N.W.; Saffitz, Jeffrey E.; Wilde, Arthur A.M.; van den Berg, Maarten P.; van Tintelen, J. Peter



The CF-modifying gene EHF promotes p.Phe508del-CFTR residual function by altering protein glycosylation and trafficking in epithelial cells.  


The three-base-pair deletion c.1521_1523delCTT (p.Phe508del, F508del) in the cystic fibrosis transmembrane conductance regulator (CFTR) is the most frequent disease-causing lesion in cystic fibrosis (CF). The CFTR gene encodes a chloride and bicarbonate channel at the apical membrane of epithelial cells. Altered ion transport of CFTR-expressing epithelia can be used to differentiate manifestations of the so-called CF basic defect. Recently, an 11p13 region has been described as a CF modifier by the North American CF Genetic Modifier Study Consortium. Selecting the epithelial-specific transcription factor EHF (ets homologous factor) as the likely candidate gene on 11p13, we have genotyped two i