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Sample records for vibracao das bombas

  1. Complete Genome Sequence of Bacillus cereus Group Phage TsarBomba

    PubMed Central

    Erill, Ivan

    2015-01-01

    The Bacillus cereus group bacteriophage TsarBomba, a double-stranded DNA Myoviridae, was isolated from soil collected in Saratov, Russia. TsarBomba was found to be similar to Bacillus phages BCP78 and BCU4, and to have a wide host range among Bacillus cereus group species. PMID:26472830

  2. Inverse steptoes in Las Bombas volcano, as an evidence of explosive volcanism in a solidified lava flow field. Southern Mendoza-Argentina

    NASA Astrophysics Data System (ADS)

    Risso, Corina; Prezzi, Claudia; Orgeira, María Julia; Nullo, Francisco; Margonari, Liliana; Németh, Karoly

    2015-11-01

    Here we describe the unusual genesis of steptoes in Las Bombas volcano- Llancanelo Volcanic Field (LVF) (Pliocene - Quaternary), Mendoza, Argentina. Typically, a steptoe forms when a lava flow envelops a hill, creating a well-defined stratigraphic relationship between the older hill and the younger lava flow. In the Llancanelo Volcanic Field, we find steptoes formed with an apparent normal stratigraphic relationship but an inverse age-relationship. Eroded remnants of scoria cones occur in "circular depressions" in the lava field. To express the inverse age-relationship between flow fields and depression-filled cones here we define this landforms as inverse steptoes. Magnetometric analysis supports this inverse age relationship, indicating reverse dipolar magnetic anomalies in the lava field and normal dipolar magnetization in the scoria cones (e.g. La Bombas). Negative Bouguer anomalies calculated for Las Bombas further support the interpretation that the scoria cones formed by secondary fracturing on already solidified basaltic lava flows. Advanced erosion and mass movements in the inner edge of the depressions created a perfectly excavated circular depression enhancing the "crater-like" architecture of the preserved landforms. Given the unusual genesis of the steptoes in LVF, we prefer the term inverse steptoe for these landforms. The term steptoe is a geomorphological name that has genetic implications, indicating an older hill and a younger lava flow. Here the relationship is reversed.

  3. DAS performance analysis

    SciTech Connect

    Bates, G.; Bodine, S.; Carroll, T.; Keller, M.

    1984-02-01

    This report begins with an overview of the Data Acquisition System (DAS), which supports several of PPPL's experimental devices. Performance measurements which were taken on DAS and the tools used to make them are then described.

  4. Das DNA-Puzzle

    NASA Astrophysics Data System (ADS)

    Kirchner, Stefan

    Im Jahre 1953 wurde von James Watson und Francis Crick erstmalig der strukturelle Aufbau der sogenannten DNA (Desoxyribonukleinsure) beschrieben, welche das Erbgut jedes Lebewesens enthlt. Der wesentliche Teil des Erbguts wird dabei durch eine sehr lange Folge der vier Basen Adenin (A), Cytosin (C), Guanin (G) und Thymin (T) codiert. Seit einigen Jahren ist es mglich, die Folge der vier Basen zu einer gegebenen DNA zu bestimmen. Biologen bezeichnen diesen Vorgang als Sequenzierung.

  5. Connecting the Dots in DAS

    ERIC Educational Resources Information Center

    Ford, Tracy

    2012-01-01

    Many institutions implement a distributed antenna system (DAS) as part of a holistic approach to providing better wireless coverage and capacity on campus. A DAS provides wireless service within a particular area or structure via a network of separate antenna nodes that are connected to a common source through fiber or coaxial cable. Because DAS

  6. Connecting the Dots in DAS

    ERIC Educational Resources Information Center

    Ford, Tracy

    2012-01-01

    Many institutions implement a distributed antenna system (DAS) as part of a holistic approach to providing better wireless coverage and capacity on campus. A DAS provides wireless service within a particular area or structure via a network of separate antenna nodes that are connected to a common source through fiber or coaxial cable. Because DAS…

  7. easyDAS: Automatic creation of DAS servers

    PubMed Central

    2011-01-01

    Background The Distributed Annotation System (DAS) has proven to be a successful way to publish and share biological data. Although there are more than 750 active registered servers from around 50 organizations, setting up a DAS server comprises a fair amount of work, making it difficult for many research groups to share their biological annotations. Given the clear advantage that the generalized sharing of relevant biological data is for the research community it would be desirable to facilitate the sharing process. Results Here we present easyDAS, a web-based system enabling anyone to publish biological annotations with just some clicks. The system, available at http://www.ebi.ac.uk/panda-srv/easydas is capable of reading different standard data file formats, process the data and create a new publicly available DAS source in a completely automated way. The created sources are hosted on the EBI systems and can take advantage of its high storage capacity and network connection, freeing the data provider from any network management work. easyDAS is an open source project under the GNU LGPL license. Conclusions easyDAS is an automated DAS source creation system which can help many researchers in sharing their biological data, potentially increasing the amount of relevant biological data available to the scientific community. PMID:21244646

  8. MyDas, an Extensible Java DAS Server

    PubMed Central

    Jimenez, Rafael C.; Quinn, Antony F.; Jenkinson, Andrew M.; Mulder, Nicola; Martin, Maria; Hunter, Sarah; Hermjakob, Henning

    2012-01-01

    A large number of diverse, complex, and distributed data resources are currently available in the Bioinformatics domain. The pace of discovery and the diversity of information means that centralised reference databases like UniProt and Ensembl cannot integrate all potentially relevant information sources. From a user perspective however, centralised access to all relevant information concerning a specific query is essential. The Distributed Annotation System (DAS) defines a communication protocol to exchange annotations on genomic and protein sequences; this standardisation enables clients to retrieve data from a myriad of sources, thus offering centralised access to end-users. We introduce MyDas, a web server that facilitates the publishing of biological annotations according to the DAS specification. It deals with the common functionality requirements of making data available, while also providing an extension mechanism in order to implement the specifics of data store interaction. MyDas allows the user to define where the required information is located along with its structure, and is then responsible for the communication protocol details. PMID:23028496

  9. Aerosole und das Klimasystem: Atmosphrenforschung

    NASA Astrophysics Data System (ADS)

    Feichter, Johann

    2003-03-01

    Aerosolpartikel beeinflussen Wetter und Klima. Sie streuen das Sonnenlicht zurck in den Weltraum oder absorbieren es und bewirken damit eine Abkhlung der Erdoberflche. Man vermutet daher, dass die anthropogen produzierten Aerosole den anthropogen verursachten Treibhauseffekt mildern. Aerosole fungieren auch als Kondensationskerne fr Wassertrpfchen und Eiskristalle, womit sie die physikalischen und optischen Eigenschaften von Wolken sowie die Verteilung der Niederschlge beeinflussen. Um die Verteilung des Aerosols realistisch simulieren und mit dem Klimasystem zu koppeln, mssen die Massenverteilung, die chemische Zusammensetzung und die Grenverteilung der Teilchen bekannt sein.

  10. DAS Writeback: A Collaborative Annotation System

    PubMed Central

    2011-01-01

    Background Centralised resources such as GenBank and UniProt are perfect examples of the major international efforts that have been made to integrate and share biological information. However, additional data that adds value to these resources needs a simple and rapid route to public access. The Distributed Annotation System (DAS) provides an adequate environment to integrate genomic and proteomic information from multiple sources, making this information accessible to the community. DAS offers a way to distribute and access information but it does not provide domain experts with the mechanisms to participate in the curation process of the available biological entities and their annotations. Results We designed and developed a Collaborative Annotation System for proteins called DAS Writeback. DAS writeback is a protocol extension of DAS to provide the functionalities of adding, editing and deleting annotations. We implemented this new specification as extensions of both a DAS server and a DAS client. The architecture was designed with the involvement of the DAS community and it was improved after performing usability experiments emulating a real annotation task. Conclusions We demonstrate that DAS Writeback is effective, usable and will provide the appropriate environment for the creation and evolution of community protein annotation. PMID:21569281

  11. Data Acquisition System(DAS) Sustaining Engineering

    NASA Technical Reports Server (NTRS)

    1998-01-01

    This paper presents general information describing the Data Acquisition System contract, a summary of objectives, tasks performed and completed. The hardware deliverables which are comprised of: 1) Two ground DAS units; 2) Two flight DAS units; 3) Logistic spares; and 4) Shipping containers are described. Also included are the data requirements and scope of the contract.

  12. "Das Konkrete ist das Abstrakte, an das man sich schlielich gewhnt hat." (Laurent Schwartz) ber den Ablauf des mathematischen Verstehens

    NASA Astrophysics Data System (ADS)

    Lowsky, Martin

    Die im Titel genannte Aussage findet sich in den Lebenserinnerungen von Laurent Schwartz (1915-2002), einem der fruchtbarsten Mathematiker, Mitglied der Gruppe Bourbaki. Im Original lautet die Aussage: "un objet concret est un objet abstrait auquel on a fini par s'habituer." Schwartz erlutert sie am Beispiel des Integrals ber {e^{-1/2{x^2}}} , das den Wert Wurzel aus 2? hat und in dem sich also die Zahlen e und ? verknpfen. Was Schwartz aber vor allem ausdrcken will, ist dies: Das mathematische Verstndnisd geht langsam vor sich und es bedarf der Anstrengung. "Es ist eine Frage der Zeit und der Energie", sagt Schwartz, und gerade dies mache es so schwer, die hhere Mathematik unter das Volk zu bringen. Das Lernen und Lehren von Mathematik laufe eben mhevoll und langsam ab.

  13. Physik gestern und heute Das Eiskalorimeter

    NASA Astrophysics Data System (ADS)

    Heering, P.

    2003-07-01

    Kalorimetrische Messungen gehren heute zum experimentellen Standardrepertoire im Bereich der Thermodynamik und der physikalischen Chemie. Das erste Gert fr derartige Messungen entwickelten Ende des 18. Jahrhunderts die franzsischen Wissenschaftler Antoine Laurent Lavoisier und Pierre Simon de Laplace.

  14. Naturphilosophie, Kosmologie und das Anthropische Prinzip.

    NASA Astrophysics Data System (ADS)

    Kanitscheider, B.

    Contents: 1. Die Rolle der Philosophie beim Verstndnis der Natur. 2. Das Kopernikanische Prinzip des Standardmodells. 3. Die anthropische Wendung. 4. Naturkonstanten und Anfangsbedingungen. 5. Sind anthropische Argumente Erklrungen?

  15. Dasty3, a WEB framework for DAS

    PubMed Central

    Villaveces, Jose M.; Jimenez, Rafael C.; Garcia, Leyla J.; Salazar, Gustavo A.; Gel, Bernat; Mulder, Nicola; Martin, Maria; Garcia, Alexander; Hermjakob, Henning

    2011-01-01

    Motivation: Dasty3 is a highly interactive and extensible Web-based framework. It provides a rich Application Programming Interface upon which it is possible to develop specialized clients capable of retrieving information from DAS sources as well as from data providers not using the DAS protocol. Dasty3 provides significant improvements on previous Web-based frameworks and is implemented using the 1.6 DAS specification. Availability: Dasty3 is an open-source tool freely available at http://www.ebi.ac.uk/dasty/ under the terms of the GNU General public license. Source and documentation can be found at http://code.google.com/p/dasty/. Contact: hhe@ebi.ac.uk PMID:21798964

  16. Das Hermann-Gitter: Optische Tuschungen

    NASA Astrophysics Data System (ADS)

    Ehrenstein, Walter H.; Lingelbach, Bernd

    2002-11-01

    1870 entdeckte Ludimar Hermann, dass Gittermuster mit starken Hell-Dunkel-Kontrasten optische Tuschungen verursachen. Solche Muster heien heute Hermann-Gitter. Seit 1960 spielt das Hermann-Gitter in der Sehforschung eine wichtige Rolle. An dem Muster knnen Modelle zur Informationsverarbeitung im visuellen System geprft werden. Inzwischen gibt es eine ganze Reihe von Modifikationen des Urmusters, die neue Wahrnehmungseffekte verursachen. Das Hermann-Gitter ist als Lackmustest fr sehphysiologische Modelle des Helligkeitskontrasts bis heute aktuell. Die vielfltigen Abwandlungen des Hermann-Gitters werfen zahlreiche neue Fragen auf, fr die es zurzeit noch keine schlssigen Antworten gibt.

  17. Mol-Gastronomie: Das Schmoren der Tripelhelix

    NASA Astrophysics Data System (ADS)

    Vilgis, Thomas

    2006-09-01

    Schmoren ist eine der beliebtesten Methoden, geschmackvolles Fleisch auf den Tisch zu zaubern, ob als Gulasch oder als klassischen Sauerbraten. Garzeiten von mehr als zwei Stunden sind keine Seltenheit. Der Grund dafr liegt in der Biophysik des durchwachsenen Schmorfleisches. Das Bindegewebe Kollagen muss zuerst in Gelatine umgewandelt werden, damit es dem Genuss keinen Widerstand mehr bietet.

  18. GHRSST-14 DAS-TAG Report

    NASA Technical Reports Server (NTRS)

    Armstrong, Edward; Piolle, Jean Francois

    2013-01-01

    The DAS-TAG provides the informatics and data management expertise in emerging information technologies for the GHRSST community. It provides expertise in data and metadata formats and standards, fosters improvements for GHRSST data curation, experiments with new data processing paradigms, and evaluates services and tools for data usage. It provides a forum for producer and distributor data management issues and coordination.

  19. Das ideale Quantenlabor: Bose-Einstein-Kondensation

    NASA Astrophysics Data System (ADS)

    Sengstock, Klaus; Bongs, Kai; Reichel, Jakob

    2003-07-01

    Bose-Einstein-Kondensate (BEC) sind extrem kalte Gase aus bosonischen Atomen, die sich alle im energetischen Grundzustand versammeln. Ein BEC ist ein perfektes Quantenlabor. Es bietet eine makroskopische Materiewelle aus vielen Tausend Teilchen an, die dem Experiment offen zugänglich ist. Das unterscheidet es von anderen makroskopischen Quantenzuständen wie der Suprafluidität oder der Supraleitung, denn diese verbergen sich in Flüssigkeiten oder Festkörpern. Das BEC ist also ein ideales Modellsystem, um diese und andere Phänomene der Quantenmechanik zu studieren. Neue Perspektiven eröffnet die schnelle Erzeugung und leichte Manipulation eines Kondensats auf einem Mikrochip. Dazu gehören auch vielfältige Anwendungen bis hin zum Quantencomputer.

  20. Moisture Forecast Bias Correction in GEOS DAS

    NASA Technical Reports Server (NTRS)

    Dee, D.

    1999-01-01

    Data assimilation methods rely on numerous assumptions about the errors involved in measuring and forecasting atmospheric fields. One of the more disturbing of these is that short-term model forecasts are assumed to be unbiased. In case of atmospheric moisture, for example, observational evidence shows that the systematic component of errors in forecasts and analyses is often of the same order of magnitude as the random component. we have implemented a sequential algorithm for estimating forecast moisture bias from rawinsonde data in the Goddard Earth Observing System Data Assimilation System (GEOS DAS). The algorithm is designed to remove the systematic component of analysis errors and can be easily incorporated in an existing statistical data assimilation system. We will present results of initial experiments that show a significant reduction of bias in the GEOS DAS moisture analyses.

  1. Das CARNOTsche Paradigma und seine erkenntnistheoretischen Implikationen

    NASA Astrophysics Data System (ADS)

    Schöpf, Hans-Georg

    Der vorliegende historisch-kritische Essay führt die Eigentümlichkeiten der klassischen phänomenologischen Thermodynamik auf das von CARNOT geschaffene Paradigma zurück und greift einige damit zusammenhängende Fragen auf.Translated AbstractCARNOT's Paradigm and its Epistemological ImplicationsThe present historic-critical essay traces the pecularities of classical phenomenological thermodynamics back to the paradigm, created by CARNOT, and takes up some questions to which this paradigm gives rise.

  2. EVITA - Das Prfverfahren zur Beurteilung von Antikollisionssystemen

    NASA Astrophysics Data System (ADS)

    Hoffmann, Jens; Winner, Hermann

    Bei der Entwicklung von Fahrerassistenzsystemen (FAS) fr die Vermeidung von Unfllen sind geeignete Testmethoden fr das Erzeugen von Bewertungen erforderlich. Fr eine grtmgliche bertragbarkeit der Versuche sind realittsnahe und reprsentative Szenarien darzustellen. Dabei gilt bisher, dass eine Vergrerung der Realittsnhe mit einer enormen Vergrerung des Aufwands einhergeht. Die Testmethoden mit Probanden fr in kritischen Situationen untersttzende FAS mssen vor allem sicher fr die beteiligten Versuchspersonen, aber auch reproduzierbar sein. Da bisher geeignete Verfahren fehlen, stellt dieser Test von Antikollisionssystemen in kritischen Situationen eine groe Herausforderung dar.

  3. Evidence of Motor Programming Deficits in Children Diagnosed with DAS.

    ERIC Educational Resources Information Center

    Nijland, Lian; Maassen, Ben; van der Meulen, Sjoeke

    2003-01-01

    Five children with developmental apraxia of speech (DAS), 5 controls (ages 5-6), and 6 adults produced utterances in a normal condition and in a bite-block condition in which the mandible was in a fixed position. In children with DAS, the bite-block had large effects on coarticulatory patterns and vowel quality. (Contains references.) (Author/CR)

  4. Pedagogical Basis of DAS Formalism in Engineering Education

    ERIC Educational Resources Information Center

    Hiltunen, J.; Heikkinen, E.-P.; Jaako, J.; Ahola, J.

    2011-01-01

    The paper presents a new approach for a bachelor-level curriculum structure in engineering. The approach is called DAS formalism according to its three phases: description, analysis and synthesis. Although developed specifically for process and environmental engineering, DAS formalism has a generic nature and it could also be used in other…

  5. Pedagogical Basis of DAS Formalism in Engineering Education

    ERIC Educational Resources Information Center

    Hiltunen, J.; Heikkinen, E.-P.; Jaako, J.; Ahola, J.

    2011-01-01

    The paper presents a new approach for a bachelor-level curriculum structure in engineering. The approach is called DAS formalism according to its three phases: description, analysis and synthesis. Although developed specifically for process and environmental engineering, DAS formalism has a generic nature and it could also be used in other

  6. DASMiner: discovering and integrating data from DAS sources

    PubMed Central

    2009-01-01

    Background DAS is a widely adopted protocol for providing syntactic interoperability among biological databases. The popularity of DAS is due to a simplified and elegant mechanism for data exchange that consists of sources exposing their RESTful interfaces for data access. As a growing number of DAS services are available for molecular biology resources, there is an incentive to explore this protocol in order to advance data discovery and integration among these resources. Results We developed DASMiner, a Matlab toolkit for querying DAS data sources that enables creation of integrated biological models using the information available in DAS-compliant repositories. DASMiner is composed by a browser application and an API that work together to facilitate gathering of data from different DAS sources, which can be used for creating enriched datasets from multiple sources. The browser is used to formulate queries and navigate data contained in DAS sources. Users can execute queries against these sources in an intuitive fashion, without the need of knowing the specific DAS syntax for the particular source. Using the source's metadata provided by the DAS Registry, the browser's layout adapts to expose only the set of commands and coordinate systems supported by the specific source. For this reason, the browser can interrogate any DAS source, independently of the type of data being served. The API component of DASMiner may be used for programmatic access of DAS sources by programs in Matlab. Once the desired data is found during navigation, the query is exported in the format of an API call to be used within any Matlab application. We illustrate the use of DASMiner by creating integrative models of histone modification maps and protein-protein interaction networks. These enriched datasets were built by retrieving and integrating distributed genomic and proteomic DAS sources using the API. Conclusion The support of the DAS protocol allows that hundreds of molecular biology databases to be treated as a federated, online collection of resources. DASMiner enables full exploration of these resources, and can be used to deploy applications and create integrated views of biological systems using the information deposited in DAS repositories. PMID:19919683

  7. Das Lob der Sternkunst. Astronomie in der deutschen Aufklrung.

    NASA Astrophysics Data System (ADS)

    Baasner, R.

    Contents: 1. Einleitung. 2. Die Astronomie im Rahmen der Aufklrungs-Physik. 3. Das Lob der Sternkunst. 4. Ein Blick auf die Sternwarten. 5. Allgemeine Darstellungen der Sternkunde. 6. Schleppende Rezeption: Das kopernikanische Weltbild. 7. Himmelsphysik: Die Debatte um die causa gravitatis. 8. Theorie der Himmelskrper. 9. Die Erde als Gegenstand der Astronomie. 10. Die Sonne. 11. Der Mond. 12. Die Planeten. 13. Die Kometen. 14. Die Fixsterne. 15. Die Entstehung der Welt. 16. Beitrge der Astrotheologie. 17. Der Kampf gegen die Astrologen.

  8. Novas determinaes dos parmetros atmosfricos das estrelas ans brancas DA

    NASA Astrophysics Data System (ADS)

    Giovannini, O.; Costa, A. F. M.; Kepler, S. O.

    2003-08-01

    Ns temos selecionado uma amostra de estrelas ans brancas DA (atmosfera de hidrognio) a partir dos ndices de Strmgren cujos valores esto prximos a regio de instabilidade das estrelas ans brancas DA variveis, as chamadas estrelas DAV ou ZZ Ceti. O objetivo determinar os parmetros fundamentais (temperatura efetiva, Teff, acelerao da gravidade, log g, e massa) destas estrelas para verificar quais os parmetros estelares esto envolvidos com o mecanismo de pulsao das estrelas DAV. Ns obtemos, at agora, mais de 120 espectros ticos de estrelas DA. Entre as estrelas selecionadas h 20 estrelas variveis (DAV). Assim, podemos verificar se existem ou no estrelas no variveis dentro da faixa de instabilidade das estrelas ZZ Ceti. Neste trabalho ns apresentamos a determinao dos parmetros atmosfricos (temperatura efetiva, Teff, e acelerao da gravidade, log g) das estrelas ans brancas DA usando os novos modelos de atmosfera ML2/a = 0.6. Estes modelos tm sido utilizados recentemente por fornecerem uma excelente consistncia interna na determinao das temperaturas nas regies do ultra-violeta e tico. Os parmetros atmosfricos so determinados espectroscopicamente atravs da comparao do fluxo de energia das linhas de Balmer (Hb H9) entre os espectros observados e sintticos (gerados pelos modelos de atmosfera). As temperaturas obtidas com os novos modelos so, em geral, menores (~ 1000 K menos) que as temperaturas determinadas anteriormente, com modelos ML1. Os valores de log g no mudaram significativamente (menos de 10%). A faixa de instabilidade das DAVs est entre 11000 e 13000 K, consistente com dados de outros autores.

  9. DAS: A Data Management System for Instrument Tests and Operations

    NASA Astrophysics Data System (ADS)

    Frailis, M.; Sartor, S.; Zacchei, A.; Lodi, M.; Cirami, R.; Pasian, F.; Trifoglio, M.; Bulgarelli, A.; Gianotti, F.; Franceschi, E.; Nicastro, L.; Conforti, V.; Zoli, A.; Smart, R.; Morbidelli, R.; Dadina, M.

    2014-05-01

    The Data Access System (DAS) is a and data management software system, providing a reusable solution for the storage of data acquired both from telescopes and auxiliary data sources during the instrument development phases and operations. It is part of the Customizable Instrument WorkStation system (CIWS-FW), a framework for the storage, processing and quick-look at the data acquired from scientific instruments. The DAS provides a data access layer mainly targeted to software applications: quick-look displays, pre-processing pipelines and scientific workflows. It is logically organized in three main components: an intuitive and compact Data Definition Language (DAS DDL) in XML format, aimed for user-defined data types; an Application Programming Interface (DAS API), automatically adding classes and methods supporting the DDL data types, and providing an object-oriented query language; a data management component, which maps the metadata of the DDL data types in a relational Data Base Management System (DBMS), and stores the data in a shared (network) file system. With the DAS DDL, developers define the data model for a particular project, specifying for each data type the metadata attributes, the data format and layout (if applicable), and named references to related or aggregated data types. Together with the DDL user-defined data types, the DAS API acts as the only interface to store, query and retrieve the metadata and data in the DAS system, providing both an abstract interface and a data model specific one in C, C++ and Python. The mapping of metadata in the back-end database is automatic and supports several relational DBMSs, including MySQL, Oracle and PostgreSQL.

  10. Einfluss des Internets auf das Informations-, Einkaufs- und Verkehrsverhalten

    NASA Astrophysics Data System (ADS)

    Nerlich, Mark R.; Schiffner, Felix; Vogt, Walter

    Mit Daten aus eigenen Erhebungen knnen das einkaufsbezogene Informations- und Einkaufsverhalten im Zusammenhang mit den verkehrlichen Aspekten (Distanzen, Verkehrsmittel, Wegekopplungen) dargestellt werden. Die Differenzierung in die drei Produktkategorien des tglichen, mittelfristigen und des langfristigen Bedarfs bercksichtigt in erster Linie die Wertigkeit eines Gutes, die seine Erwerbshufigkeit unmittelbar bestimmt. Der Einsatz moderner IKT wie das Internet erffnet dem Endverbraucher neue Mglichkeiten bei Information und Einkauf. Die verkehrliche Relevanz von Online-Shopping wird deutlich, wenn man bercksichtigt, dass im Mittel rund 17% aller Online-Einkufe, die die Probanden durchgefhrt haben, Einkufe in Ladengeschften ersetzen. Dies gilt in verstrktem Mae fr Online-Informationen: etwa die Hlfte htte alternativ im stationren Einzelhandel stattgefunden. Da der Erwerb von Gtern des tglichen Bedarfs hufig nahrumlich und in relevantem Anteil nicht-motorisiert erfolgen kann, sind in diesem Segment - im Gegensatz zum mittel- und langfristigen Bedarf - nur geringe Substitutionseffekte zu beobachten.

  11. Homo sapiens und das 21. Jahrhundert - evolutionsbiologische Betrachtungen

    NASA Astrophysics Data System (ADS)

    Oehler, Jochen

    Was meinen wir, wenn wir vom 21. Jahrhundert sprechen? Es ist ein Zeitraum, der sich durch die Festlegung des Menschen ergibt, die nach Christi Geburt verstrichene Zeit in Jahren zu zhlen. Eine kulturelle Leistung, die primr auf der Fhigkeit beruht, das Phnomen Zeit a priori wahrnehmen zu knnen. Die Antizipation der Zeit ist in der Welt der Organismen ein weit verbreitetes Prinzip. Entsprechend existieren auf zellulren bis zu zentralnervsen Ebenen verschiedenste Mechanismen, die dies ermglichen. So basiert die Zeitwahrnehmung des Menschen auf zentralnervsen Strukturen und Prozessen phylogenetisch lterer Hirnstrukturen, die ihrerseits die Krperfunktionen von der zellulren bis zur Verhaltensebene steuern und regeln und sie damit an exogene Zeitregime, wie z. B. den Tag-Nacht-Rhythmus (circadianer Rhythmus), anpassen. Die Chronobiologie weist nach, welch groe adaptive Bedeutung zeitantizipierende Mechanismen fr die Organismen haben, das heit Fitness frdernd sind (Piechulla 1999; Spork 2004). Die fr verschiedene Kulturen des Menschen magebliche Zeitrechnung basiert auf der quantitativen Erfassung kosmisch oder irdisch regelmig wiederkehrender Ereignisse.

  12. On the Law of Inertia. Translation of: Ueber das Beharrungsgesetz

    NASA Astrophysics Data System (ADS)

    Lange, Ludwig

    2014-04-01

    This article is a translation of Ludwig Lange: "Ueber das Beharrungsgesetz" in: Berichte ueber Verhandlungen der Koenigl. Saechsischen Gesellschaft der Wissenschaften, math.-physik. Klasse (Leipzig, 1885), SS. 333-351. Translated by Herbert Pfister, Institut für Theoretische Physik, Universität Tübingen, Auf der Morgenstelle 14, 72076 Tübingen, Germany; herbert.pfister@uni-tuebingen.de. Kind assistance by Julian Barbour is acknowledged.

  13. Lndliche Entwicklung durch erneuerbare Energien - Das Beispiel Photovoltaik in Niederbayern

    NASA Astrophysics Data System (ADS)

    Zink, Roland

    2013-09-01

    Der Ausbau erneuerbarer Energien ist in Deutschland eine zentrale und politisch konsensfhige Forderung, um die Energieversorgung klimafreundlich und nachhaltig zu gestalten. Speziell lndliche Regionen rcken dabei in den Fokus, bieten sie doch aufgrund ihrer hohen Flchenverfgbarkeit groe Potenziale fr die flchenintensiven dezentralen Energieformen. Folglich erkennen Kommunen zunehmend das Entwicklungspotenzial dieser Technologien und sehen sie auch als Chance, neue wirtschaftliche Impulse vor Ort zu setzen. Der Beitrag skizziert die rasante Entwicklung der Photovoltaik im Regierungsbezirk Niederbayern und diskutiert anhand des Beispiels die Folgen fr eine nachhaltige Regionalentwicklung.

  14. Statistical Quality Control of Moisture Data in GEOS DAS

    NASA Technical Reports Server (NTRS)

    Dee, D. P.; Rukhovets, L.; Todling, R.

    1999-01-01

    A new statistical quality control algorithm was recently implemented in the Goddard Earth Observing System Data Assimilation System (GEOS DAS). The final step in the algorithm consists of an adaptive buddy check that either accepts or rejects outlier observations based on a local statistical analysis of nearby data. A basic assumption in any such test is that the observed field is spatially coherent, in the sense that nearby data can be expected to confirm each other. However, the buddy check resulted in excessive rejection of moisture data, especially during the Northern Hemisphere summer. The analysis moisture variable in GEOS DAS is water vapor mixing ratio. Observational evidence shows that the distribution of mixing ratio errors is far from normal. Furthermore, spatial correlations among mixing ratio errors are highly anisotropic and difficult to identify. Both factors contribute to the poor performance of the statistical quality control algorithm. To alleviate the problem, we applied the buddy check to relative humidity data instead. This variable explicitly depends on temperature and therefore exhibits a much greater spatial coherence. As a result, reject rates of moisture data are much more reasonable and homogeneous in time and space.

  15. Sobre o uso das sries de Puiseux em mecanica celeste

    NASA Astrophysics Data System (ADS)

    Miloni, O. I.

    2003-08-01

    Neste trabalho apresentada uma demonstrao do uso dos diferentes desenvolvimentos em sries para as equaes de perturbao em Mecnica Celeste no marco Hamiltoniano. Em trabalhos clssicos como os de Poincar (Poincar, 1893) por exemplo, j esta planteado o uso de potncias no inteiras no pequeno parmetro, o que evidencia a no analiticidade das funes quando uma ressonncia ocorre. Nestes trabalhos os desenvolvimentos so na raz quadrada da massa de Jpiter (o pequeno parmetro). Mais recentemente (Ferraz-Mello, 1985) outros tipos de desenvolvimentos foram aplicados modificando substancialmente as ordens de grandeza e a velocidade de convergncia das sries. Com esta abordagem, os desenvolvimentos foram expressados em termos da raz cbica do pequeno parmetro. Neste trabalho apresentamos um enfoque geral, onde os diferentes tipos de desenvolvimentos em sries de Puiseux (Valiron, 1950) so obtidos a partir da aplicao de Teorema de Preparao de Weierstrass (Goursat, 1916) considerando a equao de Hamilton-Jacobi como uma equao algbrica. Os resultados so aplicados ao problema restrito dos trs corpos em ressonncia de primeira ordem e, dependendo da grandeza da excentricidade do asteride em relao de Jpiter, obtemos os diferentes desenvolvimentos, em raz quadrada ou raz cbica da massa de Jpiter.

  16. Die grnende IT - Wie die Computerindustrie das Energiesparen neu erfand

    NASA Astrophysics Data System (ADS)

    von Greiner, Wilhelm

    Die IT-Branche hat ihr grnes Gewissen entdeckt. In der jetzigen Verbreitung und Intensitt ist dieses Phnomen noch recht neu - lange Zeit schien die Informationstechnik in puncto Umweltvertrglichkeit und Energieverbrauch eine "weie Weste" zu haben. Schlielich luft ein PC mit Strom und nicht mit - sagen wir mal - einem Dieselmotor: Beim Booten eines Computers schiet nicht erst eine dunkelgraue Rauchwolke aus dem Auspuff, die Lrmerzeugung beschrnkt sich auf das Surren des Lfters, zum Tanken fahren muss man mit ihm auch nicht, und die Produktion der Komponenten erfolgt ja, wo eigentlich? Irgendwo in der "dritten Welt", in Fernost oder in Mexiko. So sind die umweltschdlichen Aspekte der Produktion von Leiterplatten und sonstigen Bauteilen aus den Augen, aus dem Sinn und bestenfalls sporadisch Gegenstand eines kritischen Greenpeace-Berichts1, der im berangebot der Medienlandschaft untergeht.

  17. Dasty and UniProt DAS: a perfect pair for protein feature visualization.

    PubMed

    Jones, Philip; Vinod, Nisha; Down, Thomas; Hackmann, Andre; Kahari, Andreas; Kretschmann, Ernst; Quinn, Antony; Wieser, Daniela; Hermjakob, Henning; Apweiler, Rolf

    2005-07-15

    In this study, we present two freely available and complementary Distributed Annotation System (DAS) resources: a DAS reference server that provides up-to-date sequence and annotation from UniProt, with additional feature links and database cross-references from InterPro and a DAS client implemented using Java and Macromedia Flash that is optimized for the display of protein features. PMID:15905273

  18. 50 CFR 648.53 - Target total allowable catch, DAS allocations, and individual fishing quotas.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ...) deducted from its 2011 open area DAS allocation. (ii) (5) Additional open area DAS. If a TAC for yellowtail...) When the Nantucket Lightship Access Area closes due to the yellowtail flounder bycatch TAC, for each... Nantucket Lightship Access Area closes due to the yellowtail flounder bycatch TAC, it will be...

  19. Psychometric Properties of the Disability Assessment Schedule (DAS) for Behavior Problems: An Independent Investigation

    ERIC Educational Resources Information Center

    Tsakanikos, Elias; Underwood, Lisa; Sturmey, Peter; Bouras, Nick; McCarthy, Jane

    2011-01-01

    The present study employed the Disability Assessment Schedule (DAS) to assess problem behaviors in a large sample of adults with ID (N = 568) and evaluate the psychometric properties of this instrument. Although the DAS problem behaviors were found to be internally consistent (Cronbach's [alpha] = 0.87), item analysis revealed one weak item

  20. Detecting Changes Following the Provision of Assistive Devices: Utility of the WHO-DAS II

    ERIC Educational Resources Information Center

    Raggi, Alberto

    2010-01-01

    The World Health Organization Disability Assessment Schedule II (WHO-DAS II) is a non-disease-specific International Classification of Functioning, Disability, and Health-based disability assessment instrument developed to measure activity limitations and restrictions to participation. The aim of this pilot study is to evaluate WHO-DAS II

  1. Der Beta-Zerfall der Atomkerne und das Alter des Universums.

    NASA Astrophysics Data System (ADS)

    Klapdor, H. V.

    Contents: 1. Einleitung: Schwache Wechselwirkung und Entwicklung des Universums. 2. Ein Durchbruch im Verständnis des β-Zerfalls neutronenreicher Kerne. 3. Elementsynthese und das Alter des Universums. 4. Kosmologie.

  2. BOOK REVIEW: Geheimnisvolles Universum - Europas Astronomen entschleiern das Weltall

    NASA Astrophysics Data System (ADS)

    Duerbeck, H. W.; Lorenzen, D. H.

    2002-12-01

    The 25th birthday of ESO, in 1987, was celebrated by the publication of an illustrated popular book, "Exploring the Southern Sky" (Springer-Verlag 1987), which also saw editions in Danish, English, French, German, and Spanish. Written and illustrated by the ESO staff members Svend Laustsen, Claus Madsen and Richard M. West, its many pictures were mainly taken with the ESO 3.6m and Schmidt telescopes. The structure of the book - perhaps at that time somewhat unusual - started with things far away (Universe and galaxies), zoomed in to the Milky Way, and finally reached the Solar System (with a concluding chapter dealing with the La Silla observatory). Now, with the 4 units of the Very Large Telescope in full operation, and on the occasion of ESO's 40th birthday, another jubilee book has appeared: "Geheimnisvolles Universum: Europas Astronomen entschleiern das Weltall", written by the science journalist Dirk H. Lorenzen, of Hamburg, Germany, and prefaced by Catherine Cesarsky, Director General of ESO. Presumably, this book will also soon become available in more languages spoken in ESO member countries. Thus it may be worthwhile to review the first edition, although some readers may like to wait for more easily accessible editions. Before going into details, let me first mention that I find this a very impressing book, great to look at and refreshing to read. With ESO seen through the eyes of a visitor, things gain a perspective that is quite different from that of the previous book, and at least as attractive. It comes as no surprise that the book starts with a visit of ESO's showcase, the Paranal Observatory, and the writer not only notes down his own impressions, but also cites statements of some of the many people that keep Paranal going - technicians and staff astronomers. This mixture of texts provides a good impression of the operations at a large observatory for the general reader. The two more 'astronomical' parts that follow deal with star and planet formation, stellar death and dust formation, as well as with the Universe, its beginnings and contents (focussing on quasars and SN Ia); like the previous chapters, they contain many quotations of astronomers involved in these types of research (I suppose they are taken from interviews); these blocks, each composed of three chapters, are separated by a more technical part, two chapters dealing with interferometry and adaptive optics. The last third of the book is then dedicated almost exclusively to ESO's "prehistory", and here the reviewer starts to frown. This is a very extensive report on Juergen Stock's early site testing work for US astronomers, first for Gerard Kuiper and the University of Texas, and then for the Association of Universities for Research in Astronomy (AURA), to find an suitable place for a projected telescope and then for the AURA southern observatory, with page-long excerpts from his notebooks (or the printed "Stock reports"). It also deals with Stock's later activities in Chile and Venezuela. Finally, there are a few pages on the foundation of ESO and the choice of a Chilean site, as well as another few pages on future projects of ESO. The decision of ESO to go to Chile is treated very briefly, much shorter than in Blaauw's 1991 book "ESO's Early History"; the reasons for the early focussing on a site in South Africa, and the relatively quick jump on the "Chilean bandwagon" remain quite obscure. Compared to that, the 25 pages of "Stock reports" written to help the decision making of the site of the AURA observatory, contain a lot of not-too-relevant details like prices and names of horses and mules employed in Stock's site testing survey. It is fun reading, but does not penetrate under the surface, and the author's somewhat desperate attempt to join together the ends of the threat, "also the VLT is a consequence of Juergen Stock's activities in Chile", appears not very convincing. I do not want at all to diminish Stock's immense work that made Chile to the "golden land of astronomy" in the late decades of the 20th century. Stock was sent by the US astronomers, and they became active because of Kuiper's enthusiasm, that was triggered by a visit of Federico Rutlland, director of the Astronomy Department of the Universidad de Chile - the former Chilean National Observatory, whose founding was triggered by the activities of a US astronomical expedition in the mid-19th century, headed by James Gilliss; and Gilliss was inspired by an astronomical proposition made in 1847 by Christian Gerling, a mathematics professor of Marburg. And besides this line of events, there have been other astronomical expeditions and observing stations in the north of Chile in the late 19th and early 20th century. What is the true first cause of the presently florishing astronomical activity in Chile? Certainly not the "Stock report"! At times ESO's development resembled more a random walk than a strategic process, that - given enough time and money - finally culminated in a very successful research institution. This very pretty and informative book, whose author - intentionally or unintentionally - had the courage to neglect important things, and to include irrelevant things, is not a book that tells the whole story (and actually no book can achieve this goal!). Even a book like Lorenzen's that is composed of huge fragments that do not quite fit into the story, can make fascinating reading. However, besides the publisher's logo, this book carries the ESO logo, and therefore becomes something like an "official" ESO publication. And this is why one wonders why so much space is used up to describe activities which have hardly any relation to ESO's history, a history that really deserves to be communicated to the interested general public. If this book would encourage some of the early players of ESO to pen down their memoirs and make them available to science writers and historians, a story at least as colorful as that of Juergen Stock would emerge! And only then it would be possible to write a more balanced history of ESO.

  3. VIIRS ocean color data visualization and processing with IDL-based NOAA-SeaDAS

    NASA Astrophysics Data System (ADS)

    Wang, Xiaolong; Liu, Xiaoming; Jiang, Lide; Wang, Menghua; Sun, Junqiang

    2014-11-01

    The NOAA Sea-viewing Data Analysis System (NOAA-SeaDAS) is an Interactive Data Language (IDL)-based satellite data visualization, analysis, and processing system based on the version 6.4 of the NASA's Sea-viewing Wide Field-ofview (SeaWiFS) Data Analysis System (SeaDAS) released in 2012. NOAA-SeaDAS inherited all the original functionalities of SeaDAS 6.4 and was upgraded with many new functions and new sensor supports, particularly the support of the Visible Infrared Imaging Radiometer Suite (VIIRS) onboard the Suomi National Polar-Orbiting Partnership (SNPP). The main goal of the NOAA-SeaDAS development is primarily in support of NOAA ocean color team's calibration and validation activities. The current version of NOAA-SeaDAS can visualize, analyze, and process VIIRS Sensor Data Records (SDR or Level-1B data) produced by the NOAA Interface Data Processing System (IDPS), ocean color Environmental Data Records (EDR or Level-2 data) produced by the NOAA Multi-Sensor Level-1 to Level- 2 (MSL12) ocean color data processing system, and Level-3 data binned or mapped from Level-2 data produced by NOAA-MSL12. NOAA-SeaDAS is currently serving an active IDL user group at NOAA and will serve other institutions and universities in the future. The goal is to allow various scientific users to visualize, analyze, and process VIIRS data from Level-1B through Level-2 and Level-3. In addition, NOAA-SeaDAS can also visualize satellite images from the Korean Geostationary Ocean Color Imager (GOCI), as well as many other satellite ocean color sensors, e.g., SeaWiFS, the Moderate Resolution Imaging Spectroradiometer (MODIS), etc. NOAA-SeaDAS is under constant development to create new system functionalities and enhance user experience. With constantly increasing volume in the global ocean color data archive, NOAA-SeaDAS will play an important role in support of global marine environment data analysis and various scientific applications.

  4. Integriertes Informationsmanagement an der Westflischen Wilhelms-Universitt Mnster - Das Projekt MIRO

    NASA Astrophysics Data System (ADS)

    Vogl, Raimund; Gildhorn, Antje; Labitzke, Jrg; Wibberg, Michael

    An der Westflischen Wilhelms-Universitt Mnster (WWU) wurde bereits 1996 ein tragfhiges, kooperativ ausgerichtetes System der IT-Governance im Zusammenspiel zentraler und dezentraler IT-Leistungserbringer etabliert. Um den Anforderungen an ein integriertes Informationsmanagement im berlappungsfeld von Information, Kommunikation und Medien (IKM) durch das Zusammenspiel der zentralen Einrichtungen Universittsverwaltung (UniV), Universitts- und Landesbibliothek (ULB) und Zentrum fr Informationsverarbeitung (ZIV) gerecht zu werden, wurde 2003 der IKM-Service institutionalisiert. In diesem Rahmen wurde das Projekt Mnster Information System for Research and Organization (MIRO) entwickelt, das als Leistungszentrum fr Forschungsinformation von der DFG gefrdert wird. Die bisherigen Projekterfahrungen, erreichten Ziele und verbleibenden Aufgaben werden dargestellt. Im Projektverlauf haben sich insbesondere die etablierten IT-Governance und Versorgungs-Strukturen sowie die Untersttzung der Hochschulleitung als essentielle Erfolgskriterien erwiesen.

  5. Amerikas Einschätzung der deutschen Atomforschung: Das deutsche Uranprojekt

    NASA Astrophysics Data System (ADS)

    Walker, Mark

    2002-07-01

    Die amerikanischen Wissenschaftler und ihre emigrierten Kollegen, die am Bau der Atombombe beteiligt waren, verfügten über sehr widersprüchliche und großteils falsche Informationen über den Fortschritt des deutschen Uranprogramms. Noch nach Kriegsende lässt sich dies an Aussagen des Leiters der amerikanischen Alsos-Mission, Samuel Goudsmit, festmachen. Tatsächlich war das deutsche Programm hinsichtlich seiner wissenschaftlichen Grundlagen und des Managements nicht so unterlegen, wie vielfach behauptet wurde. Aber die deutschen Behörden waren nicht in der Lage, Geld und Ressourcen in gleichem Maße in das Uranprojekt zu investieren, wie etwa in das Peenemünder Raketenprojekt.

  6. Global Gridded Data from the Goddard Earth Observing System Data Assimilation System (GEOS-DAS)

    NASA Technical Reports Server (NTRS)

    2001-01-01

    The Goddard Earth Observing System Data Assimilation System (GEOS-DAS) timeseries is a globally gridded atmospheric data set for use in climate research. This near real-time data set is produced by the Data Assimilation Office (DAO) at the NASA Goddard Space Flight Center in direct support of the operational EOS instrument product generation from the Terra (12/1999 launch), Aqua (05/2002 launch) and Aura (01/2004 launch) spacecrafts. The data is archived in the EOS Core System (ECS) at the Goddard Earth Sciences Data and Information Services Center/Distributed Active Archive Center (GES DISC DAAC). The data is only a selection of the products available from the GEOS-DAS. The data is organized chronologically in timeseries format to facilitate the computation of statistics. GEOS-DAS data will be available for the time period January 1, 2000, through present.

  7. The Deaf Acculturation Scale (DAS): Development and Validation of a 58-Item Measure

    PubMed Central

    Maxwell-McCaw, Deborah; Zea, Maria Cecilia

    2011-01-01

    This study involved the development and validation of the Deaf Acculturation Scale (DAS), a new measure of cultural identity for Deaf and hard-of-hearing (hh) populations. Data for this study were collected online and involved a nation-wide sample of 3,070 deaf/hh individuals. Results indicated strong internal reliabilities for all the subscales, and construct validity was established by demonstrating that the DAS could discriminate groups based on parental hearing status, school background, and use of self-labels. Construct validity was further demonstrated through factorial analyses, and findings resulted in a final 58-item measure. Directions for future research are discussed. PMID:21263041

  8. Ballistic transport in extended Datta-Das spin field effect transistors

    NASA Astrophysics Data System (ADS)

    Xiao, Yun-Chang; Zhu, Rui; Deng, Wen-Ji

    2011-09-01

    The model of the Datta-Das spin field effect transistor [S. Datta, B. Das, Appl. Phys. Lett. 56 (1990) 665] is extended in several respects: (1) the Rashba effect and Dresselhaus effect coexist; (2) the incoming and outgoing leads are both ferromagnetic; (3) the interfacial scattering and band mismatch are taken into account. By using the Griffith boundary conditions, the transmission coefficients and, thus, the Landauer-Bttiker conductance are obtained analytically. The transmission probability and conductance of the spin field effect transistor are studied in detail.

  9. Knaurs moderne Astronomie. Das Standardwerk völlig neu bearbeitet.

    NASA Astrophysics Data System (ADS)

    Störig, H. J.

    This elementary textbook covers the following topics: cosmic dimensions, the sun as a star, the solar system, basic knowledge about stars, binary and variable stars, the cosmic windows, birth and death of stars, the Milky Way, extragalactic systems and cosmology. Contents: 1. Weißt du, wieviel Sterne stehen... 2. Die Sonne als Durchschnittsstern. 3. Das Sonnensystem im Überblick. 4. Grundwissen über Sterne. 5. Doppelsterne und Veränderliche. 6. Fenster zum Weltall. 7. Geburt und Tod der Sterne. 8. Die Milchstraße. 9. Extragalaktische Systeme. 10. Das Weltganze in Raum und Zeit.

  10. Das Prinzip Bewegung - Herz und Gehirn als Metaphern des menschlichen Lebens

    NASA Astrophysics Data System (ADS)

    Otis, Laura

    In diesem Jahr, in dem wir Charles Darwins gedenken, möchte ich etwas riskieren und eine Frage erörtern, die für die Literatur ebenso wie für die Biologie zentral ist: Was ist das Leben? Die Antwort auf diese Frage finden wir nicht in der Bibliothek und nicht im Labor, zumindest nicht an diesen erkenntnisproduzierenden Stellen allein. Als Literaturwissenschaftlerin und ehemalige Naturwissenschaftlerin glaube ich, dass wir das Leben nur verstehen werden, wenn wir seinen Wirkungen überall nachforschen, inklusive in der Literatur.

  11. Das Informatik-Forum Stuttgart - mehr Dialog zwischen Theorie und Anwendung notwendig

    NASA Astrophysics Data System (ADS)

    Hieber, Ludwig

    Mit der Gründung des Informatik- Forum Stuttgart wird seit 1996 eine Plattform angeboten, die den Dialog zwischen der universitären Forschung, der Informatikausbildung und der IT-Wirtschaft in der Region Stuttgart intensivieren soll. In der Informatik hat sich eine Lücke zwischen Theorie und Anwendung entwickelt. Es ist nicht erkennbar, dass diese Lücke kleiner wird, eher das Gegenteil zeichnet sich ab. Verglichen mit anderen Branchen besteht die Gefahr, dass Anwender wesentlich später von Erkenntnissen aus der Forschung profitieren. Der entstandene Interaktionsstau zwischen Theorie und Anwendung der Informatik sollte abgebaut werden. An einigen Beispielen wird aufgezeigt, wo das besonders wichtig erscheint.

  12. An exploratory analysis of the factor structure of the Dysfunctional Attitude Scale-Form A (DAS).

    PubMed

    Moore, Michael T; Fresco, David M; Segal, Zindel V; Brown, Timothy A

    2014-10-01

    A number of studies have attempted to identify the factor structure of the Dysfunctional Attitude Scale (DAS). However, no studies have done so using a clinical sample of outpatients likely to generalize to the clinical trials in which the DAS is commonly used. The current investigation utilized exploratory structural equation modeling in an outpatient sample (N = 982) and found support for a one-factor solution (composed of 19 items). This solution was largely confirmed in a second outpatient sample (N = 301). Construct validity was demonstrated in correlations with measures of depression, social interaction anxiety, and symptoms of obsessive-compulsive disorder. PMID:24577308

  13. The SeaDAS Processing and Analysis System: SeaWiFS, MODIS, and Beyond

    NASA Astrophysics Data System (ADS)

    MacDonald, M. D.; Ruebens, M.; Wang, L.; Franz, B. A.

    2005-12-01

    The SeaWiFS Data Analysis System (SeaDAS) is a comprehensive software package for the processing, display, and analysis of ocean data from a variety of satellite sensors. Continuous development and user support by programmers and scientists for more than a decade has helped to make SeaDAS the most widely used software package in the world for ocean color applications, with a growing base of users from the land and sea surface temperature community. Full processing support for past (CZCS, OCTS, MOS) and present (SeaWiFS, MODIS) sensors, and anticipated support for future missions such as NPP/VIIRS, enables end users to reproduce the standard ocean archive product suite distributed by NASA's Ocean Biology Processing Group (OBPG), as well as a variety of evaluation and intermediate ocean, land, and atmospheric products. Availability of the processing algorithm source codes and a software build environment also provide users with the tools to implement custom algorithms. Recent SeaDAS enhancements include synchronization of MODIS processing with the latest code and calibration updates from the MODIS Calibration Support Team (MCST), support for all levels of MODIS processing including Direct Broadcast, a port to the Macintosh OS X operating system, release of the display/analysis-only SeaDAS-Lite, and an extremely active web-based user support forum.

  14. OntoDas a tool for facilitating the construction of complex queries to the Gene Ontology

    PubMed Central

    O'Neill, Kieran; Garcia, Alexander; Schwegmann, Anita; Jimenez, Rafael C; Jacobson, Dan; Hermjakob, Henning

    2008-01-01

    Background Ontologies such as the Gene Ontology can enable the construction of complex queries over biological information in a conceptual way, however existing systems to do this are too technical. Within the biological domain there is an increasing need for software that facilitates the flexible retrieval of information. OntoDas aims to fulfil this need by allowing the definition of queries by selecting valid ontology terms. Results OntoDas is a web-based tool that uses information visualisation techniques to provide an intuitive, interactive environment for constructing ontology-based queries against the Gene Ontology Database. Both a comprehensive use case and the interface itself were designed in a participatory manner by working with biologists to ensure that the interface matches the way biologists work. OntoDas was further tested with a separate group of biologists and refined based on their suggestions. Conclusion OntoDas provides a visual and intuitive means for constructing complex queries against the Gene Ontology. It was designed with the participation of biologists and compares favourably with similar tools. It is available at PMID:18925933

  15. MiDAS: the field guide to the microbes of activated sludge.

    PubMed

    McIlroy, Simon Jon; Saunders, Aaron Marc; Albertsen, Mads; Nierychlo, Marta; McIlroy, Bianca; Hansen, Aviaja Anna; Karst, Sren Michael; Nielsen, Jeppe Lund; Nielsen, Per Halkjr

    2015-01-01

    The Microbial Database for Activated Sludge (MiDAS) field guide is a freely available online resource linking the identity of abundant and process critical microorganisms in activated sludge wastewater treatment systems to available data related to their functional importance. Phenotypic properties of some of these genera are described, but most are known only from sequence data. The MiDAS taxonomy is a manual curation of the SILVA taxonomy that proposes a name for all genus-level taxa observed to be abundant by large-scale 16?S rRNA gene amplicon sequencing of full-scale activated sludge communities. The taxonomy can be used to classify unknown sequences, and the online MiDAS field guide links the identity to the available information about their morphology, diversity, physiology and distribution. The use of a common taxonomy across the field will provide a solid foundation for the study of microbial ecology of the activated sludge process and related treatment processes. The online MiDAS field guide is a collaborative workspace intended to facilitate a better understanding of the ecology of activated sludge and related treatment processes--knowledge that will be an invaluable resource for the optimal design and operation of these systems. PMID:26120139

  16. Flashbacks: Reminiscences from 40 Years with the J.P. Das Developmental Disabilities Centre

    ERIC Educational Resources Information Center

    Das, J. P.

    2008-01-01

    In this article, the author reminisces about his 40 years with the J.P. Das Developmental Disabilities Centre. He begins by recalling his early years with the Centre. He follows it up with his middle years, as well as his later years with the Centre. The author ends his flashback by "bragging" about some of the extraordinary scholars who have…

  17. The Deaf Acculturation Scale (DAS): Development and Validation of a 58-Item Measure

    ERIC Educational Resources Information Center

    Maxwell-McCaw, Deborah; Zea, Maria Cecilia

    2011-01-01

    This study involved the development and validation of the Deaf Acculturation Scale (DAS), a new measure of cultural identity for Deaf and hard-of-hearing (hh) populations. Data for this study were collected online and involved a nation-wide sample of 3,070 deaf/hh individuals. Results indicated strong internal reliabilities for all the subscales,

  18. MiDAS: the field guide to the microbes of activated sludge

    PubMed Central

    McIlroy, Simon Jon; Saunders, Aaron Marc; Albertsen, Mads; Nierychlo, Marta; McIlroy, Bianca; Hansen, Aviaja Anna; Karst, Søren Michael; Nielsen, Jeppe Lund; Nielsen, Per Halkjær

    2015-01-01

    The Microbial Database for Activated Sludge (MiDAS) field guide is a freely available online resource linking the identity of abundant and process critical microorganisms in activated sludge wastewater treatment systems to available data related to their functional importance. Phenotypic properties of some of these genera are described, but most are known only from sequence data. The MiDAS taxonomy is a manual curation of the SILVA taxonomy that proposes a name for all genus-level taxa observed to be abundant by large-scale 16 S rRNA gene amplicon sequencing of full-scale activated sludge communities. The taxonomy can be used to classify unknown sequences, and the online MiDAS field guide links the identity to the available information about their morphology, diversity, physiology and distribution. The use of a common taxonomy across the field will provide a solid foundation for the study of microbial ecology of the activated sludge process and related treatment processes. The online MiDAS field guide is a collaborative workspace intended to facilitate a better understanding of the ecology of activated sludge and related treatment processes—knowledge that will be an invaluable resource for the optimal design and operation of these systems. Database URL: http://www.midasfieldguide.org PMID:26120139

  19. Physik gestern und heute Das Experiment von Einstein und de Haas

    NASA Astrophysics Data System (ADS)

    Engels, Wolfgang

    2005-07-01

    Als Einstein sich 1915 mitten in der Entwicklung der Allgemeinen Relativittstheorie befand, widmete er sich einem alten physikalischen Problem: Wie lsst sich der Magnetismus auf atomarer Ebene erklren? Mit dem niederlndischen Physiker Wander Johannes de Haas realisierte er ein Experiment, das nach den beiden Forschern benannt wurde.

  20. A Brief History of the J.P. Das Developmental Disabilities Centre

    ERIC Educational Resources Information Center

    Sobsey, Dick

    2008-01-01

    The J.P. Das Developmental Disabilities Centre celebrated its 40th anniversary on September 1, 2007, followed by The University of Alberta's 100th anniversary in 2008. The year 2008 also brought the appointment of a new Director for the Centre. As the immediate past Director of the Centre, the author recounts some of the history of the J.P. Das…

  1. I/O Parallelization for the Goddard Earth Observing System Data Assimilation System (GEOS DAS)

    NASA Technical Reports Server (NTRS)

    Lucchesi, Rob; Sawyer, W.; Takacs, L. L.; Lyster, P.; Zero, J.

    1998-01-01

    The National Aeronautics and Space Administration (NASA) Data Assimilation Office (DAO) at the Goddard Space Flight Center (GSFC) has developed the GEOS DAS, a data assimilation system that provides production support for NASA missions and will support NASA's Earth Observing System (EOS) in the coming years. The GEOS DAS will be used to provide background fields of meteorological quantities to EOS satellite instrument teams for use in their data algorithms as well as providing assimilated data sets for climate studies on decadal time scales. The DAO has been involved in prototyping parallel implementations of the GEOS DAS for a number of years and is now embarking on an effort to convert the production version from shared-memory parallelism to distributed-memory parallelism using the portable Message-Passing Interface (MPI). The GEOS DAS consists of two main components, an atmospheric General Circulation Model (GCM) and a Physical-space Statistical Analysis System (PSAS). The GCM operates on data that are stored on a regular grid while PSAS works with observational data that are scattered irregularly throughout the atmosphere. As a result, the two components have different data decompositions. The GCM is decomposed horizontally as a checkerboard with all vertical levels of each box existing on the same processing element(PE). The dynamical core of the GCM can also operate on a rotated grid, which requires communication-intensive grid transformations during GCM integration. PSAS groups observations on PEs in a more irregular and dynamic fashion.

  2. Incorporating Parallel Computing into the Goddard Earth Observing System Data Assimilation System (GEOS DAS)

    NASA Technical Reports Server (NTRS)

    Larson, Jay W.

    1998-01-01

    Atmospheric data assimilation is a method of combining actual observations with model forecasts to produce a more accurate description of the earth system than the observations or forecast alone can provide. The output of data assimilation, sometimes called the analysis, are regular, gridded datasets of observed and unobserved variables. Analysis plays a key role in numerical weather prediction and is becoming increasingly important for climate research. These applications, and the need for timely validation of scientific enhancements to the data assimilation system pose computational demands that are best met by distributed parallel software. The mission of the NASA Data Assimilation Office (DAO) is to provide datasets for climate research and to support NASA satellite and aircraft missions. The system used to create these datasets is the Goddard Earth Observing System Data Assimilation System (GEOS DAS). The core components of the the GEOS DAS are: the GEOS General Circulation Model (GCM), the Physical-space Statistical Analysis System (PSAS), the Observer, the on-line Quality Control (QC) system, the Coupler (which feeds analysis increments back to the GCM), and an I/O package for processing the large amounts of data the system produces (which will be described in another presentation in this session). The discussion will center on the following issues: the computational complexity for the whole GEOS DAS, assessment of the performance of the individual elements of GEOS DAS, and parallelization strategy for some of the components of the system.

  3. The Great War and Remembrance in Jose Leon Machado's "Memoria das Estrelas sem Brilho"

    ERIC Educational Resources Information Center

    Azevedo, Milton M.

    2011-01-01

    This article analyzes Jose Leon Machado's novel, "Memoria das Estrelas sem Brilho," as a multilayered historical novel in which a war story provides a background for comments on aspects of early twentieth-century Portuguese society, such as male bonding, religion, sexual mores, and social stratification. (Contains 11 notes.)

  4. A 90 day chronic toxicity study of Nigerian herbal preparation DAS-77 in rats

    PubMed Central

    2012-01-01

    Background The herbal preparation DAS-77, used for the treatment of various ailments in Nigeria, contains the milled bark of Mangifera indica L. and root of Carica papaya L. Toxicological assessment of the preparation was carried out in this study. Methods In the acute toxicity study, DAS-77 was administered to mice p.o. up to 20 g/kg in divided doses and i.p. at 2503000 mg/kg. Mortality within 24 h was recorded. In the chronic toxicity study, rats were treated p.o. for 90 days at doses of 80, 400 (therapeutic dose, TD) and 2000 mg/kg. By 90 days, animals were sacrificed and blood samples collected for hematological and biochemical analysis. Organs were harvested for weight determination, antioxidants and histopathological assessments. Results DAS-77 did not produce any lethality administered p.o. up to 20 g/kg in divided doses but the i.p. LD50 was 1122.0 mg/kg. At TD, DAS-77 produced significant (p?DAS-77 is relatively safe with the potential for enhancing in vivo antioxidant activity. However, possibly reversible side-effects include electrolyte imbalance and sterility in males. PMID:22892317

  5. The rat Digit Abduction Score (DAS) assay: a physiological model for assessing botulinum neurotoxin-induced skeletal muscle paralysis.

    PubMed

    Broide, Ron S; Rubino, John; Nicholson, Gregory S; Ardila, Maria C; Brown, Meenakshi S; Aoki, K Roger; Francis, Joseph

    2013-09-01

    Botulinum neurotoxins (BoNT) are approved for a number of therapeutic indications, including blepharospasm, cervical dystonia and hyperhidrosis, and have also shown efficacy in a variety of pain disorders. The potency of any given BoNT preparation can be routinely assessed by using the Digit Abduction Score (DAS) assay, which measures the local muscle weakening efficacy of BoNT following injection into mouse hindlimb muscle. While most studies have employed mice to assess BoNT efficacy in the DAS, few have utilized rats. In this study, we applied the DAS assay to a rat model and compared the potency of IM-BOTOX() (onabotulinumtoxinA) injections between two separate hind limb muscles, gastrocnemius and tibialis anterior (TA). The results demonstrated that the DAS assay can be performed on rats with similar criteria and parameters as for mice. Moreover in the rat, BoNT can be injected into either the gastrocnemius or TA muscle to elicit similar DAS scoring responses. Interestingly, onabotulinumtoxinA potency in the rat DAS was ?3-fold higher following TA injections than gastrocnemius injections. Additionally, our data showed that the durational kinetics of onabotulinumtoxinA in the rat DAS are approximately twice as long as in the mouse DAS. These results position the rat DAS as a more flexible model for examining the mechanisms of BoNT diffusion and muscle paralysis, while mouse DAS can be used for physiological screening of BoNT because of the potential for higher throughput. Overall, these data confirm the utility of the DAS assay for characterizing the physiological potency of BoNT and related compounds. PMID:23707612

  6. DAS Boot!

    ERIC Educational Resources Information Center

    Chretien, Wendy

    2007-01-01

    The residential services group is lobbying to dump its aging hard-wired phone system because students don't use it. The town and campus public safety officials are demanding that their portable two-way radios operate well not only outdoors, but within campus buildings. Students are now expecting text messaging and WiFi service to work everywhere

  7. DAS Boot!

    ERIC Educational Resources Information Center

    Chretien, Wendy

    2007-01-01

    The residential services group is lobbying to dump its aging hard-wired phone system because students don't use it. The town and campus public safety officials are demanding that their portable two-way radios operate well not only outdoors, but within campus buildings. Students are now expecting text messaging and WiFi service to work everywhere…

  8. 50 CFR 648.53 - Acceptable biological catch (ABC), annual catch limits (ACL), annual catch targets (ACT), DAS...

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... conversion of 8.33 lb (3.78 kg) of scallop meats per bushel shall be used to calculate meat-weight, up to a... chart depicting the area previously known as the Elephant Trunk Access Area are available from the... paragraph (b)(4)(vi) but the DAS conversion is applied as a DAS credit in the 2011 fishing year, rather...

  9. Tengo una Bomba: The Paralinguistic and Linguistic Conventions of the Oral Practice Chismeando.

    ERIC Educational Resources Information Center

    Hall, Joan Kelly

    1993-01-01

    This article offers a linguistic and paralinguistic explication of the oral practice of chismeando (gossiping) as engaged in by a group of women from the Dominican Republic. A culture-specific study of the structuring resources by which the participants construct, maintain, and/or modify their in-group identities in everyday oral practice is

  10. MITK-IGT: Eine Navigationskomponente fr das Medical Imaging Interaction Toolkit

    NASA Astrophysics Data System (ADS)

    Neuhaus, Jochen; Wegner, Ingmar; Kst, Johannes; Baumhauer, Matthias; Seitel, Alexander; Gergel, Ingmar; Nolden, Marco; Maleike, Daniel; Wolf, Ivo; Meinzer, H.-P.; Maier-Hein, Lena

    MITK-IGT ist eine Erweiterung des Medical Imaging Interaction Toolkits, die es ermglicht Softwareprogramme im Bereich bildgesttzte Therapie zu erstellen. Dieser Beitrag stellt die Architektur und Designprinzipien von MITK-IGT vor und vergleicht sie mit anderen Open Source Lsungen. Neben der Ansteuerung von Trackingsystemen und Visualisierungsmodulen liegt der Fokus von MITK-IGT auf einer Filterarchitektur, die das schrittweise Verarbeiten von Trackingdaten erlaubt. Zur BVM 2009 wird die erste Version von MITK-IGT als Open Source verffentlicht.

  11. Verknpfung von DQ-Indikatoren mit KPIs und Auswirkungen auf das Return on Investment

    NASA Astrophysics Data System (ADS)

    Block, Frank

    Hufig ist nicht klar, welche Beziehungen zwischen Datenqualittsindikatoren (DQI, Definition folgt weiter unten) und Key Performance Indicators (KPI, s. Abschnitt 1.3 fr weitere Details) eines Unternehmens oder einer Organisation bestehen. Dies ist insbesondere deshalb von Bedeutung, da die Kenntnis dieser Beziehungen mageblich die Ausprgung eines Datenqualittsprojekts beeinflusst. Sie ist als Entscheidungsgrundlage unabdingbar und gibt Antworten auf folgende Fragen: Was kostet unserem Unternehmen/unserer Organisation1 schlechte Datenqualitt? Knnen wir uns das leisten?

  12. Das Projekt "Satelliten- und Inertialgeodsie" der Bayerischen Kommission fr die Internationale Erdmessung.

    NASA Astrophysics Data System (ADS)

    Sigl, R.; Ehrnsperger, W.; Wende, W.; Boedecker, G.; Neumayer, K. H.

    Contents: 1. Zur Entwicklung des Projektes "Satelliten- und Inertialgeodsie" (R. Sigl). 2. EUREF - Erstellung eines fundamentalen 3-D Festpunktfeldes in Europa (W. Ehrnsperger). 3. Genauigkeitssteigerung in der geodtischen Astronomie durch den FK5 Sternkatalog. Neuauswertung von astronomisch bestimmten Lngendifferenzen im Europischen Lngennetz (ELN) (W. Wende). 4. Status des Projektes "Inertialschwere" zur Bestimmung des Schwerevektors aus Inertial- und GPS-Messungen (G. Boedecker). 5. Stochastische Modelle fr Satelliten- und Empfngeruhren sowie fr das Gravitationsfeld (K. H. Neumayer).

  13. Lagenwechsel minimieren - oder das Bohren von Löchern in Leiterplatten

    NASA Astrophysics Data System (ADS)

    Grötschel, Martin; Koch, Thorsten; Hoàng, Nam Dũng

    Diese Aufgabe behandelt ein Problem, das beim Entwurf von Leiterplatten auftritt. Die Aufgabe ist rein kombinatorischer Natur, man benötigt keine Kenntnisse der Elektromechanik. Einfache Leiterplatten haben zwei Seiten (auch Lagen genannt), auf die Strom leitende Bahnen (genannt Leiterbahnen) aufgebracht werden können. Wir nennen diese Lagen obere und untere Lage. Abbildung 1 zeigt eine unbestückte Leiterplatte und ihren "Schatten", der die Löcher in der Leiterplatte sichtbar macht.

  14. CLAES Product Improvement by Use of the GSFC Data Assimilation System (DAS)

    NASA Technical Reports Server (NTRS)

    Kumer, J. B.; Douglass, Anne (Technical Monitor)

    2000-01-01

    This report presents the Cryogenic Limb Array Etalon Spectrometer (CLAES) product improvement by use of the GSFC Data Assimilation System (DAS). The first task is to plug line of sight gradients derived from the CTM for 2/20/92 into the forward model of our retrieval software (RSW) in order to assess the impact on the retrieved quantities. The reporting period covers 12 May 2000 - 21 December 2000.

  15. Assimilation of SBUV Version 8 Radiances into the GEOS Ozone DAS

    NASA Technical Reports Server (NTRS)

    Mueller, Martin D.; Stajner, Ivanka; Bhartia, Pawan K.

    2004-01-01

    In operational weather forecasting, the assimilation of brightness temperatures from satellite sounders, instead of assimilation of 1D-retrievals has become increasingly common practice over the last two decades. Compared to these systems, assimilation of trace gases is still at a relatively early stage of development, and efforts to directly assimilate radiances instead of retrieved products have just begun a few years ago, partially because it requires much more computation power due to the employment of a radiative transport forward model (FM). This paper will focus on a method to assimilate SBUV/2 radiances (albedos) into the Global Earth Observation System Ozone Data Assimilation Scheme (GEOS-03DAS). While SBUV-type instruments cannot compete with newer sensors in terms of spectral and horizontal resolution, they feature a continuous data record back to 1978, which makes them very valuable for trend studies. Assimilation can help spreading their ground coverage over the whole globe, as has been previously demonstrated with the GEOS-03DAS using SBUV Version 6 ozone profiles. Now, the DAS has been updated to use the newly released SBUV Version 8 data. We will compare pre]lmlnarv results of SBUV radiance assimilation with the assimilation of retrieved ozone profiles, discuss methods to deal with the increased computational load, and try to assess the error characteristics and future potential of the new approach.

  16. Annotation and visualization of endogenous retroviral sequences using the Distributed Annotation System (DAS) and eBioX

    PubMed Central

    Martínez Barrio, Álvaro; Lagercrantz, Erik; Sperber, Göran O; Blomberg, Jonas; Bongcam-Rudloff, Erik

    2009-01-01

    Background The Distributed Annotation System (DAS) is a widely used network protocol for sharing biological information. The distributed aspects of the protocol enable the use of various reference and annotation servers for connecting biological sequence data to pertinent annotations in order to depict an integrated view of the data for the final user. Results An annotation server has been devised to provide information about the endogenous retroviruses detected and annotated by a specialized in silico tool called RetroTector. We describe the procedure to implement the DAS 1.5 protocol commands necessary for constructing the DAS annotation server. We use our server to exemplify those steps. Data distribution is kept separated from visualization which is carried out by eBioX, an easy to use open source program incorporating multiple bioinformatics utilities. Some well characterized endogenous retroviruses are shown in two different DAS clients. A rapid analysis of areas free from retroviral insertions could be facilitated by our annotations. Conclusion The DAS protocol has shown to be advantageous in the distribution of endogenous retrovirus data. The distributed nature of the protocol is also found to aid in combining annotation and visualization along a genome in order to enhance the understanding of ERV contribution to its evolution. Reference and annotation servers are conjointly used by eBioX to provide visualization of ERV annotations as well as other data sources. Our DAS data source can be found in the central public DAS service repository, , or at . PMID:19534743

  17. I/O Parallelization for the Goddard Earth Observing System Data Assimilation System (GEOS DAS)

    NASA Technical Reports Server (NTRS)

    Lucchesi, R.; Sawyer, W.; Takacs, L. L.; Lyster, P.; Zero, J.

    1999-01-01

    The National Aeronautics and Space Administration (NASA) Data Assimilation Office (DAO) at the Goddard Space Flight Center (GSFC) has developed the GEOS DAS, a data assimilation system that provides production support for NASA missions and will support NASA's Earth Observing System (EOS) in the coming years. The DAO's support of the EOS project along with the requirement of producing long-term reanalysis datasets with an unvarying system levy a large I/O burden on the future system. The DAO has been involved in prototyping parallel implementations of the GEOS DAS for a number of years and is now converting the production version from shared-memory parallelism to distributed-memory parallelism using the portable Message-Passing Interface (MPI). If the MPI-based GEOS DAS is to meet these production requirements, we must make I/O from the parallel system efficient. We have designed a scheme that allows efficient I/O processing while retaining portability, reducing the need for post-processing, and producing data formats that are required by our users, both internal and external. The first phase of the GEOS DAS Parallel I/O System (GPIOS) will expand upon the common method of gathering global data to a Single PE for output. Instead of using a PE also tasked with primary computation, a number of PEs will be dedicated to I/O and its related tasks. This allows the data transformations and formatting required prior to output to take place asynchronously with respect to the GEOS DAS assimilation cycle, improving performance and generating output data sets in a format convenient for our users. I/O PEs can be added as needed to handle larger data volumes or to meet user file specifications. We will show I/O performance results from a prototype MPI GCM integrated with GPIOS. Phase two of GPIOS development will examine ways of integrating new software technologies to further improve performance and build scalability into the system. The maturing of MPI-IO implementations and other supporting libraries such as parallel HDF should provide performance gains while retaining portability.

  18. Validation of Land-Surface Mosaic Heterogeneity in the GEOS DAS

    NASA Technical Reports Server (NTRS)

    Bosilovich, Michael G.; Molod, Andrea; Houser, Paul R.; Schubert, Siegfried

    1999-01-01

    The Mosaic Land-surface Model (LSM) has been included into the current GEOS Data Assimilation System (DAS). The LSM uses a more advanced representation of physical processes than previous versions of the GEOS DAS, including the representation of sub-grid heterogeneity of the land-surface through the Mosaic approach. As a first approximation, Mosaic assumes that all similar surface types within a grid-cell can be lumped together as a single'tile'. Within one GCM grid-cell, there might be 1 - 5 different tiles or surface types. All tiles are subjected to the grid-scale forcing (radiation, air temperature and specific humidity, and precipitation), and the sub-grid variability is a function of the tile characteristics. In this paper, we validate the LSM sub-grid scale variability (tiles) using a variety of surface observing stations from the Southern Great Plains (SGP) site of the Atmospheric Radiation Measurement (ARM) Program. One of the primary goals of SGP ARM is to study the variability of atmospheric radiation within a G,CM grid-cell. Enough surface data has been collected by ARM to extend this goal to sub-grid variability of the land-surface energy and water budgets. The time period of this study is the Summer of 1998 (June I - September 1). The ARM site data consists of surface meteorology, energy flux (eddy correlation and bowen ratio), soil water observations spread over an area similar to the size of a G-CM grid-cell. Various ARM stations are described as wheat and alfalfa crops, pasture and range land. The LSM tiles considered at the grid-space (2 x 2.5) nearest the ARM site include, grassland, deciduous forests, bare soil and dwarf trees. Surface energy and water balances for each tile type are compared with observations. Furthermore, we will discuss the land-surface sub-grid variability of both the ARM observations and the DAS.

  19. Das Zweikörperproblem in der quantisierten, trägheitsfreien Mechanik

    NASA Astrophysics Data System (ADS)

    Kreisel, E.

    Es existieren keine gebundenen Zustände des Zweiteilchensystems in der Riemann-Machschen Quantenmechanik. Das Energie-Spektrum ist notwendig positiv semidefinit und kontinuierlich, in Analogie zum freien Teilchen der Quantenmechanik.Translated AbstractThe Two-Body-Problem in Quantized, Inertia-Free MechanicsThere do not exist bound states of the two-particle-system in Riemann-Machian quantum mechanics. The spectrum of the energy is necessarily positively semidefinite and continuous, in analogy to the free particle of quantum mechanics.

  20. [An example of partnership cooperation. Cantonal League against Tuberculosis and Lung Diseases/Association "Das Band"].

    PubMed

    Michaelis, E

    1984-01-01

    Together with the Cantonal League against Tuberculosis and Lung Diseases of Zurich, the Association "Das Band" has organized a first course for parents of children with asthma. The course is a component of the associations new "Prophylaxis Program for Children with Asthma and Their Parents". By exchanging ideas, the parents should become able to reflect their situation, characterized by excessive protectionism, aggressiveness, and guiltiness, and they also should learn to accept the disease as a part of their daily life. The first course, which meanwhile is followed by a second one, provided a first base for the solution of the many problems. PMID:6475318

  1. Semantic Web Revisited - Eine kurze Einfhrung in das Social Semantic Web

    NASA Astrophysics Data System (ADS)

    Blumauer, Andreas; Pellegrini, Tassilo

    Whrend in den vergangenen Monaten Themen wie Web 2.0 und Social Software ein erstaunliches Konjunkturhoch erlebt haben, vollzieht sich weitgehend abseits der ffentlichen Wahrnehmung eine technologische Komplementrinnovation. Die wachsende Adaption semantischer Technologien zu Zwecken der strukturierten Erschlieung von Web 2.0 Content", aber auch der Einsatz von Social Software zur kollaborativen Anreicherung von Web Content mit maschinenlesbaren Metadaten sind Ausdruck eines Trends in Richtung Social Semantic Web". Bezeichnendes Merkmal dieser Entwicklung ist die voranschreitende Konvergenz zwischen Social Software und Semantic Web Technologien. Dieser Beitrag hat das Ziel ein allgemeines Bewusstsein und Verstndnis dieser Entwicklung zu schaffen und nhert sich dem Phnomen aus einer nichttechnischen Perspektive.

  2. The S2 VLBI Systems: DAS, RT/PT and Correlator

    NASA Technical Reports Server (NTRS)

    Petrachenko, William T.; Bujold, Marc; Cannon, Wayne H.; Carlson, Brent R.; Dewdney, Peter E.; Feil, Georg H.; Newby, Paul; Novikov, Alexander; Popelar, Josef; Wietfeldt, Richard D.

    2000-01-01

    The S2 VLBI system synthesizes wide IF bandwidths by rapidly switching the local oscillator (LO) frequency in a small (1-4) number of baseband converters (BBC's). Data are recorded on video cassettes using an array of 8 VHS transports. Characteristics of the S2 Data Acquisition System (DAS), the S2 Record and Playback Terminals (RT and PT) and the S2 Correlator are summarized. The bandwidth synthesis (BWS) frequency switching sequence used in a series of system validation experiments is presented.

  3. The development of Music in Dementia Assessment Scales (MiDAS)

    PubMed Central

    McDermott, Orii; Orrell, Martin; Ridder, Hanne Mette

    2015-01-01

    There is a need to develop an outcome measure specific to music therapy in dementia that reflects a holistic picture of the therapy process and outcome. This study aimed to develop a clinically relevant and scientifically robust music therapy outcome measure incorporating the values and views of people with dementia. Focus groups and interviews were conducted to obtain qualitative data on what music meant to people with dementia and the observed effects of music. Expert and peer consultations were conducted at each stage of the measure development to maximise its content validity. The new measure was field-tested by clinicians in a care home. Feedback from the clinicians and music therapy experts were incorporated during the review and refinement process of the measure. A review of the existing literature, the experiential results and the consensus process enabled the development of the new outcome measure “Music in Dementia Assessment Scales (MiDAS)”. Analysis of the qualitative data identified five key areas of the impact of music on people with dementia and they were transformed as the five Visual Analogue Scale (VAS) items: levels of Interest, Response, Initiation, Involvement and Enjoyment. MiDAS comprises the five VAS items and a supplementary checklist of notable positive and negative reactions from the individual. This study demonstrates that it is possible to design and develop an easy to apply and rigorous quantitative outcome measure which has a high level of clinical relevance for people with dementia, care home staff and music therapists. PMID:26246670

  4. Ocean Color Measurements from Landsat-8 OLI using SeaDAS

    NASA Technical Reports Server (NTRS)

    Franz, Bryan Alden; Bailey, Sean W.; Kuring, Norman; Werdell, P. Jeremy

    2014-01-01

    The Operational Land Imager (OLI) is a multi-spectral radiometer hosted on the recently launched Landsat-8 satellite. OLI includes a suite of relatively narrow spectral bands at 30-meter spatial resolution in the visible to shortwave infrared that make it a potential tool for ocean color radiometry: measurement of the reflected spectral radiance upwelling from beneath the ocean surface that carries information on the biogeochemical constituents of the upper ocean euphotic zone. To evaluate the potential of OLI to measure ocean color, processing support was implemented in SeaDAS, which is an open-source software package distributed by NASA for processing, analysis, and display of ocean remote sensing measurements from a variety of satellite-based multi-spectral radiometers. Here we describe the implementation of OLI processing capabilities within SeaDAS, including support for various methods of atmospheric correction to remove the effects of atmospheric scattering and absorption and retrieve the spectral remote-sensing reflectance (Rrs; sr exp 1). The quality of the retrieved Rrs imagery will be assessed, as will the derived water column constituents such as the concentration of the phytoplankton pigment chlorophyll a.

  5. A causa das estações do ano: modelos mentais

    NASA Astrophysics Data System (ADS)

    de Campos, J. A. S.; de Araujo, J. F. S.

    2003-08-01

    A década de 70 do século passado foi marcada pelo estudo das concepções alternativas que os alunos trazem para a sala de aula. A identificação destas concepções foi o ponto de partida para promover a mudança conceitual, onde as pré-concepções seriam trocadas pelas concepções científicas. Na década seguinte, surgiram muitas propostas de estratégias educacionais para facilitar esta troca, na sua maioria baseadas na idéia do conflito cognitivo, proposta por Piaget. Entretanto, os resultados pouco animadores conduziram à percepção de que a mudança conceitual é um processo mais complexo. Pelas idéias da Ciência Cognitiva, a mudança conceitual é uma mudança progressiva dos modelos mentais que o aluno tem sobre o mundo físico, através de enriquecimento e revisão. A causa das Estações do Ano é um tópico sobre o qual a maioria dos estudantes apresenta concepções alternativas. Os autores fizeram um levantamento sobre as pré-concepções encontradas em trabalhos sobre o tema (16 referências), procurando encontrar elementos comuns que indicassem a presença de modelos mentais específicos. As pré-concepções encontradas na literatura foram obtidas usando-se diversas metodologias (desde entrevistas clínicas até questionários de múltipla escolha) e envolvendo alunos e professores de diferentes regiões geográficas. A partir de uma análise aprofundada de cada trabalho, e utilizando-se a técnica das Redes Sistêmicas, chegou-se a conclusão que as diversas pré-concepções identificadas (em torno de 50), poderiam ser representadas por 6 modelos mentais, onde a explicação da causa das estações do ano tem um mecanismo causal responsável. Os mecanismos causais identificados foram: a dependência da distância, a dependência da orientação, a dependência conjunta da distância e orientação, a dependência da obstrução, a dependência da velocidade e a dependência da inclinação dos raios solares. Foram ainda identificadas associações alternativas, que são um conjunto de pré-concepções, onde não existe a idéia de um modelo científico completo mas, sim, fragmentos de observação do dia a dia das pessoas.

  6. DasPy – Open Source Multivariate Land Data Assimilation Framework with High Performance Computing

    NASA Astrophysics Data System (ADS)

    Han, Xujun; Li, Xin; Montzka, Carsten; Kollet, Stefan; Vereecken, Harry; Hendricks Franssen, Harrie-Jan

    2015-04-01

    Data assimilation has become a popular method to integrate observations from multiple sources with land surface models to improve predictions of the water and energy cycles of the soil-vegetation-atmosphere continuum. In recent years, several land data assimilation systems have been developed in different research agencies. Because of the software availability or adaptability, these systems are not easy to apply for the purpose of multivariate land data assimilation research. Multivariate data assimilation refers to the simultaneous assimilation of observation data for multiple model state variables into a simulation model. Our main motivation was to develop an open source multivariate land data assimilation framework (DasPy) which is implemented using the Python script language mixed with C++ and Fortran language. This system has been evaluated in several soil moisture, L-band brightness temperature and land surface temperature assimilation studies. The implementation allows also parameter estimation (soil properties and/or leaf area index) on the basis of the joint state and parameter estimation approach. LETKF (Local Ensemble Transform Kalman Filter) is implemented as the main data assimilation algorithm, and uncertainties in the data assimilation can be represented by perturbed atmospheric forcings, perturbed soil and vegetation properties and model initial conditions. The CLM4.5 (Community Land Model) was integrated as the model operator. The CMEM (Community Microwave Emission Modelling Platform), COSMIC (COsmic-ray Soil Moisture Interaction Code) and the two source formulation were integrated as observation operators for assimilation of L-band passive microwave, cosmic-ray soil moisture probe and land surface temperature measurements, respectively. DasPy is parallelized using the hybrid MPI (Message Passing Interface) and OpenMP (Open Multi-Processing) techniques. All the input and output data flow is organized efficiently using the commonly used NetCDF file format. Online 1D and 2D visualization of data assimilation results is also implemented to facilitate the post simulation analysis. In summary, DasPy is a ready to use open source parallel multivariate land data assimilation framework.

  7. Establishment of feeder-free culture system for human induced pluripotent stem cell on DAS nanocrystalline graphene.

    PubMed

    Lee, Hyunah; Nam, Donggyu; Choi, Jae-Kyung; Arazo-Bravo, Marcos J; Kwon, Soon-Yong; Zaehres, Holm; Lee, Taehee; Park, Chan Young; Kang, Hyun-Wook; Schler, Hans R; Kim, Jeong Beom

    2016-01-01

    The maintenance of undifferentiated human pluripotent stem cells (hPSC) under xeno-free condition requires the use of human feeder cells or extracellular matrix (ECM) coating. However, human-derived sources may cause human pathogen contamination by viral or non-viral agents to the patients. Here we demonstrate feeder-free and xeno-free culture system for hPSC expansion using diffusion assisted synthesis-grown nanocrystalline graphene (DAS-NG), a synthetic non-biological nanomaterial which completely rule out the concern of human pathogen contamination. DAS-NG exhibited advanced biocompatibilities including surface nanoroughness, oxygen containing functional groups and hydrophilicity. hPSC cultured on DAS-NG could maintain pluripotency in vitro and in vivo, and especially cell adhesion-related gene expression profile was comparable to those of cultured on feeders, while hPSC cultured without DAS-NG differentiated spontaneously with high expression of somatic cell-enriched adhesion genes. This feeder-free and xeno-free culture method using DAS-NG will facilitate the generation of clinical-grade hPSC. PMID:26846167

  8. Establishment of feeder-free culture system for human induced pluripotent stem cell on DAS nanocrystalline graphene

    PubMed Central

    Lee, Hyunah; Nam, Donggyu; Choi, Jae-Kyung; Araúzo-Bravo, Marcos J.; Kwon, Soon-Yong; Zaehres, Holm; Lee, Taehee; Park, Chan Young; Kang, Hyun-Wook; Schöler, Hans R.; Kim, Jeong Beom

    2016-01-01

    The maintenance of undifferentiated human pluripotent stem cells (hPSC) under xeno-free condition requires the use of human feeder cells or extracellular matrix (ECM) coating. However, human-derived sources may cause human pathogen contamination by viral or non-viral agents to the patients. Here we demonstrate feeder-free and xeno-free culture system for hPSC expansion using diffusion assisted synthesis-grown nanocrystalline graphene (DAS-NG), a synthetic non-biological nanomaterial which completely rule out the concern of human pathogen contamination. DAS-NG exhibited advanced biocompatibilities including surface nanoroughness, oxygen containing functional groups and hydrophilicity. hPSC cultured on DAS-NG could maintain pluripotency in vitro and in vivo, and especially cell adhesion-related gene expression profile was comparable to those of cultured on feeders, while hPSC cultured without DAS-NG differentiated spontaneously with high expression of somatic cell-enriched adhesion genes. This feeder-free and xeno-free culture method using DAS-NG will facilitate the generation of clinical-grade hPSC. PMID:26846167

  9. Establishment of feeder-free culture system for human induced pluripotent stem cell on DAS nanocrystalline graphene

    NASA Astrophysics Data System (ADS)

    Lee, Hyunah; Nam, Donggyu; Choi, Jae-Kyung; Araúzo-Bravo, Marcos J.; Kwon, Soon-Yong; Zaehres, Holm; Lee, Taehee; Park, Chan Young; Kang, Hyun-Wook; Schöler, Hans R.; Kim, Jeong Beom

    2016-02-01

    The maintenance of undifferentiated human pluripotent stem cells (hPSC) under xeno-free condition requires the use of human feeder cells or extracellular matrix (ECM) coating. However, human-derived sources may cause human pathogen contamination by viral or non-viral agents to the patients. Here we demonstrate feeder-free and xeno-free culture system for hPSC expansion using diffusion assisted synthesis-grown nanocrystalline graphene (DAS-NG), a synthetic non-biological nanomaterial which completely rule out the concern of human pathogen contamination. DAS-NG exhibited advanced biocompatibilities including surface nanoroughness, oxygen containing functional groups and hydrophilicity. hPSC cultured on DAS-NG could maintain pluripotency in vitro and in vivo, and especially cell adhesion-related gene expression profile was comparable to those of cultured on feeders, while hPSC cultured without DAS-NG differentiated spontaneously with high expression of somatic cell-enriched adhesion genes. This feeder-free and xeno-free culture method using DAS-NG will facilitate the generation of clinical-grade hPSC.

  10. Genome-Wide Analysis of In Vivo Binding of the Master Regulator DasR in Streptomyces coelicolor Identifies Novel Non-Canonical Targets

    PubMed Central

    Świątek-Połatyńska, Magdalena A.; Bucca, Giselda; Laing, Emma; Gubbens, Jacob; Titgemeyer, Fritz; Smith, Colin P.; Rigali, Sébastien; van Wezel, Gilles P.

    2015-01-01

    Streptomycetes produce a wealth of natural products, including over half of all known antibiotics. It was previously demonstrated that N-acetylglucosamine and secondary metabolism are closely entwined in streptomycetes. Here we show that DNA recognition by the N-acetylglucosamine-responsive regulator DasR is growth-phase dependent, and that DasR can bind to sites in the S. coelicolor genome that have no obvious resemblance to previously identified DasR-responsive elements. Thus, the regulon of DasR extends well beyond what was previously predicted and includes a large number of genes with functions far removed from N-acetylglucosamine metabolism, such as genes for small RNAs and DNA transposases. Conversely, the DasR regulon during vegetative growth largely correlates to the presence of canonical DasR-responsive elements. The changes in DasR binding in vivo following N-acetylglucosamine induction were studied in detail and a possible molecular mechanism by which the influence of DasR is extended is discussed. Discussion of DasR binding was further informed by a parallel transcriptome analysis of the respective cultures. Evidence is provided that DasR binds directly to the promoters of all genes encoding pathway-specific regulators of antibiotic production in S. coelicolor, thereby providing an exquisitely simple link between nutritional control and secondary metabolism. PMID:25875084

  11. Subchronic feeding study with genetically modified stacked trait lepidopteran and coleopteran resistant (DAS-157-1xDAS-59122-7) maize grain in Sprague-Dawley rats.

    PubMed

    Appenzeller, Laura M; Malley, Linda; Mackenzie, Susan A; Hoban, Denise; Delaney, Bryan

    2009-07-01

    DAS-157-1xDAS-59122-7 (1507x59122) is a genetically modified (GM) maize hybrid that was produced by crossing of two GM maize inbreds; DAS-157-1 and DAS-59122-7. This hybrid cross expresses four transgenic proteins: Cry1F and PAT (from DAS-157-1) and Cry34Ab1/Cry35Ab1 and PAT (from DAS-59122-7) that confer resistance to lepidopteran and coleopteran pests and tolerance to the herbicidal active ingredient glufosinate-ammonium. The current subchronic feeding study was conducted in Sprague-Dawley rats to evaluate the potential health effects of long-term consumption of a rodent diet containing 1507x59122 maize grain compared with a diet containing maize grain from its near-isogenic control (091). Diets formulated with three unrelated non-GM commercial hybrids (3573, 35P12, 36G12) were also included for within study reference data. All diets contained 34% (w/wt) maize grain and were prepared according to the specifications of PMI((R)) Nutrition International, LLC Certified Rodent LabDiet((R)) 5002 (PMI((R)) 5002). Diets were fed ad libitum to rats for at least 92days. OECD 408 response variables from rats fed the 1507x59122 diet were compared with those from rats fed the 091 control diet. No toxicologically significant differences were observed in nutritional performance variables, clinical and neurobehavioral signs, ophthalmology, clinical pathology (hematology, clinical chemistry, coagulation, and urinalysis), organ weights, and gross and microscopic pathology between rats in the 091 and 1507x59122 treatment groups. The results from this study demonstrate that 1507x59122 maize grain is as safe and nutritious as non-GM maize grain and support the concept that crossing of two safe GM maize events results in production of a safe stacked GM event. PMID:19358870

  12. On the structure of poly d(A-S4T).

    PubMed Central

    Bkemeier, W; Lezius, A G

    1986-01-01

    The helical twist of poly d(A-s4T) was determined from the periodicity of the cleavage patterns of the double stranded polydeoxynucleotide adsorbed on calcium phosphate and found to be 14 bp per turn. Both cleavage patterns and 31P NMR spectra indicate a mononucleotide structure rather than an alternating B DNA like poly d(A-T). The failure of nucleosome formation excludes a B type structure. The discrepancy of the mononucleotide structure found in 31P NMR spectra and the dinucleotide structure given by X ray fiber diffraction is explained by an alternating tilt of the planes of the base pairs (base roll) as a consequence of a strong propeller twist. The importance of interstrand stacking interactions of adjacent 4-thiothymidines for the helical stability is discussed. PMID:3960720

  13. Cometa Hyakutake (C/1996 B2): anlise do gs e caractersticas fsicas das partculas de poeira

    NASA Astrophysics Data System (ADS)

    Sanzovo, G. C.; de Almeida, A. A.; Boczko, R.

    2003-08-01

    A completa caracterizao e compreenso do ncleo de um cometa novo de fundamental importncia para a elucidao dos processos fsicos e qumicos atuantes na poca da formao do Sistema Solar. O Cometa Hyakutake, conjuntamente com o Cometa Hale-Bopp representam os objetos mais brilhantes que visitaram o Sistema Solar Interno nos ltimos 20 anos. Neste Trabalho, ns aplicamos o Mtodo Semi-Emprico das Magnitudes Visuais (MSEMV) aproximadamente 4000 dados observacionais que correlacionam a magnitude visual absoluta com a distncia heliocntrica para o Cometa Hyakutake nas fases pr- e ps-perilicas. Como produto da aplicao desse mtodo, conseguimos caracterizar dimensionalmente seu ncleo e rea ativa efetiva. As taxas de produo dos radicais CN, C2 e C3, obtidos a partir de dados disponveis na literatura, revelam que, alm de muito brilhante, o Hyakutake um cometa "normal" no sentido de Cochran (1986). Desse modo, deduzimos as taxas de perdas de gua (em molculas/s) a partir da anlise de sua magnitude visual aparente, e as convertemos em taxas de perdas de gs (em g/s), despreendido pelo nucleo cometrio. Com o auxlio do modelo fotomtrico clssico da poeira, realizamos uma anlise sistemtica e uniforme dessa componente cometria, a partir dos fluxos observacionais no contnuo, para os comprimentos de onda 365,0 e 484,5 nm, assumindo que esses fluxos so o resultado da radiao solar espalhada por gros de partculas micromtricos presentes na coma. Com isso, pudemos obter as taxas de produo (em g/s), cores (relativas cor neutra solar), e as dimenses efetivas mdias das partculas de poeira, bem como as razes poeira-gs.

  14. Massa do gs e das estrelas em aglomerados: eficincia da formao estelar

    NASA Astrophysics Data System (ADS)

    Lagan, T. F.; Lima Neto, G. B.

    2003-08-01

    Os aglomerados de galxias apresentam um interesse especial para a cosmologia observacional. Eles so as maiores estruturas ligadas pela gravitao no Universo e relaxadas na regio central. A comparao entre a massa do gs intra-aglomerado (responsvel por ~25% da massa total, inferida a partir de observaes em raios-X), a massa contida nas estrelas (i.e., nas galxias) e a massa total (incluindo a matria escura no barinica), nos d informaes importantes sobre os processos de formao e evoluo de aglomerados. Por exemplo, a razo entre a massa do gs e a massa total uma medida da frao de brions no Universo (razo entre a matria barinica e matria escura) e, utilizando a densidade de brions predita pela nucleosntese primordial, podemos deduzir a densidade de matria escura no Universo (cf. White et al. 1993). O objetivo deste trabalho obter as razes entre as massas do gs, estelar (contida nas galxias), e a total (massa dinmica). As massas do gs e total so obtidas a partir das anlises fotomtrica e espectroscpica em raios-X enquanto que a massa estelar obtida pela anlise fotomtrica das galxias. Esta anlise foi aplicada ao aglomerado Abell 496 observado pelo satlite XMM-Newton. A massa contida nas galxias foi estimada a partir da funo de luminosidade obtida por Durret et al. (2002). Para determinar as massas dinmica e do gs nos precisamos determinar os perfis radiais de densidade e temperatura. Ns apresentaremos aqui estes resultados e suas implicaes na eficincia da formao estelar em Abell 496.

  15. Growth equations for the Wolf-Villain and Das Sarma-Tamborenea models of molecular-beam epitaxy

    NASA Astrophysics Data System (ADS)

    Huang, Zhi-Feng; Gu, Bing-Lin

    1996-12-01

    We derive the growth equations for the Wolf-Villain and Das Sarma-Tamborenea models based on the master-equation method. The Wolf-Villain model is shown to obey the conserved growth equation ?h/?t=-?4?4h+?22?2(?h)2+?n=1 ??12n+1?.(?h)2n+1+F+?, which is expected to exhibit the scaling behavior of the Edwards-Wilkinson universality class. We find that the Das Sarma-Tamborenea model is governed by the Villain-Lai-Das Sarma equation ?h/?t=-?4?4h+?22?2(?h)2+F+? in contrast to former results. The physical origin of the difference between these two similar models is also discussed.

  16. Observaes das exploses csmicas de raios gama GRB021004 e GRB021211 com o satlite HETE

    NASA Astrophysics Data System (ADS)

    Braga, J.; Ricker, G.; Hurley, K.; Lamb, D.; Grew, G.; et al.

    2003-08-01

    O High Energy Transient Explorer (HETE) o primeiro satlite inteiramente dedicado ao estudo das exploses csmicas de raios gama (ECRGs). Lanado em 9 de outubro de 2000, o HETE possui instrumentao capaz de observar as ECRGs desde o UV at raios gama e localiz-las com preciso de ~ 1-10 minutos de arco. As localizaes das ECRGs detectadas so disseminadas rapidamente (em alguns segundos) pela Internet atravs de uma rede de estaes de recepo ao longo do equador. A participao brasileira nesse projeto se d atravs da montagem e operao de uma estao de recepo em Natal, RN, e da participao na equipe cientfica da misso. Neste trabalho so apresentados resultados da observao pelo HETE de duas ECRGs: GRB 021004 e GRB 021211. A GRB021004 foi detectada em raios gama pelo HETE em 4 de outubro de 2002 e localizada em raios-X em apenas 48 s, quando a emisso de raios gama ainda estava se processando. A exploso, relativamente brilhante e longa, durou aproximadamente 100 s. Um transiente ptico de magnitude 15 foi detectado no local da exploso nove minutos aps o evento, e observaes realizadas aps 7 horas determinaram um desvio para o vermelho de absoro de 1,6. O GRB021004 foi o burst mais bem observado at o momento e suas observaes em vrios comprimentos de onda tm sido fundamentais para o aprimoramento dos modelos de ECRGs. O GRB21211, um burst brilhante e rico em raios-X, foi detectado em 11 de dezembro de 2002 e localizado em raios-X em 22 s aps o incio do evento. A durao do burst foi de 2,3 s em altas energias (85 a 400 keV) e de 8,5 s em baixas energias (2 a 10 keV). Caso essa exploso no tivesse sido rapidamente localizada pelo HETE, ela teria sido classificada como "opticamente escura", j que o transiente ptico decaiu rapidamente de R < 14 a R19 dentro dos primeiros 20 minutos e j estava mais fraco do que R23 depois de 24 horas da ocorrncia do burst. Sero discutidas as implicaes desse resultado nos modelos de afterglows de ECRGs.

  17. Test Review: Naglieri, J. A., Das, J. P., & Goldstein, S. (2014). Cognitive Assessment System-Second Edition (2nd Ed.)

    ERIC Educational Resources Information Center

    McGill, Ryan J.

    2015-01-01

    The Cognitive Assessment System-Second Edition (CAS2) is an individually administered measure of cognitive ability designed for children and adolescents ages 5 through 18 years. The measure, authored by Jack A. Naglieri, J. P. Das, and Sam Goldstein, was published by Pro-Ed in 2014 and is the first revision of the Cognitive Assessment System (CAS;

  18. DAS181 Treatment of Severe Parainfluenza Virus 3 Pneumonia in Allogeneic Hematopoietic Stem Cell Transplant Recipients Requiring Mechanical Ventilation

    PubMed Central

    Dhakal, B.; D'Souza, A.; Pasquini, M.; Saber, W.; Fenske, T. S.; Moss, R. B.; Drobyski, W. R.; Hari, P.; Abidi, M. Z.

    2016-01-01

    Parainfluenza virus (PIV) may cause life-threatening pneumonia in allogeneic hematopoietic stem cell transplant (HSCT) recipients. Currently, there are no proven effective therapies. We report the use of inhaled DAS181, a novel sialidase fusion protein, for treatment of PIV type 3 pneumonia in two allogeneic hematopoietic SCT recipients with respiratory failure. PMID:26941799

  19. Elevated Background in DAS-I ELISA for the Detection of Citrus Tristeza Virus in Mandarin Varieties

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Healthy tissue extracts from mandarin orange varieties occasionally resulted in elevated absorbance which can exceed twice that of healthy sweet orange tissue extracts in DAS-I-ELISA detection with an expressed coat protein polyclonal antiserum of Citrus tristeza virus (CTV). This problem occurs se...

  20. Concurrent Validity of the WISC-IV and DAS-II in Children with Autism Spectrum Disorder

    ERIC Educational Resources Information Center

    Kuriakose, Sarah

    2014-01-01

    Cognitive assessments are used for a variety of research and clinical purposes in children with autism spectrum disorder (ASD). This study establishes concurrent validity of the Wechsler Intelligence Scales for Children-fourth edition (WISC-IV) and Differential Ability Scales-second edition (DAS-II) in a sample of children with ASD with a broad

  1. Latent Factor Structure of the Das-Naglieri Cognitive Assessment System: A Confirmatory Factor Analysis in a Chinese Setting

    ERIC Educational Resources Information Center

    Deng, Ci-ping; Liu, Ming; Wei, Wei; Chan, Raymond C. K.; Das, J. P.

    2011-01-01

    This study aims to measure the psychometric properties of the Das-Naglieri Cognitive Assessment System (D-N CAS) and to determine its clinical utility in a Chinese context. Confirmatory factor analysis (CFA) was conducted to examine the construct validity of the Chinese version of the D-N CAS among a group of 567, normally developed children.

  2. Concurrent Validity of the WISC-IV and DAS-II in Children with Autism Spectrum Disorder

    ERIC Educational Resources Information Center

    Kuriakose, Sarah

    2014-01-01

    Cognitive assessments are used for a variety of research and clinical purposes in children with autism spectrum disorder (ASD). This study establishes concurrent validity of the Wechsler Intelligence Scales for Children-fourth edition (WISC-IV) and Differential Ability Scales-second edition (DAS-II) in a sample of children with ASD with a broad…

  3. Measuring Primary Teachers' Attitudes toward Teaching Science: Development of the Dimensions of Attitude toward Science (DAS) Instrument

    ERIC Educational Resources Information Center

    van Aalderen-Smeets, Sandra; Walma van der Molen, Juliette

    2013-01-01

    In this article, we present a valid and reliable instrument which measures the attitude of in-service and pre-service primary teachers toward teaching science, called the Dimensions of Attitude Toward Science (DAS) Instrument. Attention to the attitudes of primary teachers toward teaching science is of fundamental importance to the

  4. DAS181 Treatment of Severe Parainfluenza Virus 3 Pneumonia in Allogeneic Hematopoietic Stem Cell Transplant Recipients Requiring Mechanical Ventilation.

    PubMed

    Dhakal, B; D'Souza, A; Pasquini, M; Saber, W; Fenske, T S; Moss, R B; Drobyski, W R; Hari, P; Abidi, M Z

    2016-01-01

    Parainfluenza virus (PIV) may cause life-threatening pneumonia in allogeneic hematopoietic stem cell transplant (HSCT) recipients. Currently, there are no proven effective therapies. We report the use of inhaled DAS181, a novel sialidase fusion protein, for treatment of PIV type 3 pneumonia in two allogeneic hematopoietic SCT recipients with respiratory failure. PMID:26941799

  5. Goddard Earth Observing System - Data Assimilation System (GEOS-4 DAS) Data Products at the NASA Goddard Earth Science DISC DAAC

    NASA Technical Reports Server (NTRS)

    2003-01-01

    This list contains the names of data products from the Goddard Earth Observing System - Data Assimilation System (GEOS-4 DAS) at the Goddard Earth Science (GES) Data and Information Services Center (DISC) Distributed Active Archive Center (DAAC). The list divides the data products into Assimilated Synoptic Files and Assimilated Time Averaged Files.

  6. Latent Factor Structure of the Das-Naglieri Cognitive Assessment System: A Confirmatory Factor Analysis in a Chinese Setting

    ERIC Educational Resources Information Center

    Deng, Ci-ping; Liu, Ming; Wei, Wei; Chan, Raymond C. K.; Das, J. P.

    2011-01-01

    This study aims to measure the psychometric properties of the Das-Naglieri Cognitive Assessment System (D-N CAS) and to determine its clinical utility in a Chinese context. Confirmatory factor analysis (CFA) was conducted to examine the construct validity of the Chinese version of the D-N CAS among a group of 567, normally developed children.…

  7. Test Review: Naglieri, J. A., Das, J. P., & Goldstein, S. (2014). Cognitive Assessment System-Second Edition (2nd Ed.)

    ERIC Educational Resources Information Center

    McGill, Ryan J.

    2015-01-01

    The Cognitive Assessment System-Second Edition (CAS2) is an individually administered measure of cognitive ability designed for children and adolescents ages 5 through 18 years. The measure, authored by Jack A. Naglieri, J. P. Das, and Sam Goldstein, was published by Pro-Ed in 2014 and is the first revision of the Cognitive Assessment System (CAS;…

  8. Parallel Proportion Fair Scheduling in DAS with Partial Channel State Information

    NASA Astrophysics Data System (ADS)

    Jiang, Zhanjun; Wu, Jiang; Wang, Dongming; You, Xiaohu

    A parallel multiplexing scheduling (PMS) scheme is proposed for distributed antenna systems (DAS), which greatly improves average system throughput due to multi-user diversity and multi-user multiplexing. However, PMS has poor fairness because of the use of the “best channel selection” criteria in the scheduler. Thus we present a parallel proportional fair scheduling (PPFS) scheme, which combines PMS with proportional fair scheduling (PFS) to achieve a tradeoff between average throughput and fairness. In PPFS, the “relative signal to noise ratio (SNR)” is employed as a metric to select the user instead of the “relative throughput” in the original PFS. And only partial channel state information (CSI) is fed back to the base station (BS) in PPFS. Moreover, there are multiple users selected to transmit simultaneously at each slot in PPFS, while only one user occupies all channel resources at each slot in PFS. Consequently, PPFS improves fairness performance of PMS greatly with a relatively small loss of average throughput compared to PFS.

  9. Using Distributed Acoustic Sensing (DAS) for Multichannel Analysis of Surface Waves (MASW) to Evaluate Ground Stiffness

    NASA Astrophysics Data System (ADS)

    Baldwin, J. A.; Fratta, D.; Wang, H. F.; Lord, N. E.; Chalari, A.; Karaulanov, R.; Nigbor, R. L.; Lancelle, C.; Castongia, E.

    2014-12-01

    Since its introduction by Park, et al. (1999), Multichannel Analysis of Surface Waves (MASW) has become an invaluable geophysical technique for geotechnical site investigation. The technique is primarily focused on developing 2-D and 3-D shear stiffness vs. depth images of the near surface. MASW involves measuring surfaces waves of various frequencies produced by a seismic source, such as a sledgehammer or vibroseis source, which is evaluated to determine the velocity of the shear waves propagating through the subsurface at shallow depths. Traditionally, this technique relies on a long string of geophones as receivers. However, our study utilized a Distributed Acoustic Sensor array to detect ground motion caused by passing surface waves at a spatial resolution of one meter. The purpose of this investigation is to compare the effectiveness of using a DAS array for MASW data collection instead of traditional geophones. Data were collected at the Network for Earthquake Engineering Simulation's Garner Valley Downhole Array site (NEES's GVDA). Various time-frequency filtering and moving window cross correlation (MWCC) techniques were examined for extracting the surface wave dispersion. The results were found to be in good agreement with those previously obtained by Stokoe et al. (2004).

  10. Das Universum der Sterne. Himmelsbeobachtungen und Streifzüge durch die moderne Astronomie.

    NASA Astrophysics Data System (ADS)

    Rowan-Robinson, M.

    This book is a German translation, by M. Röser, of the English original published in 1990 (see 52.003.046). Contents: 1. Der Halleysche Komet. 2. Alpha Centauri - Der sonnennächste Stern. 3. Sirius und sein Begleiter, ein Weißer Zwerg. 4. Polaris - Der Polarstern. 5. Wega - Ein Planetensystem im Entstehen? 6. Mira - Der erste bekannte veränderliche Stern. 7. Der Ring-Nebel - "Todeskampf" eines sonnenähnlichen Sterns. 8. Der Orion-Nebel - Die Geburt neuer Sterne. 9. Delta Cephei - Die Meßlatte des Weltalls. 10. Algol - Der Teufelsstern. 11. Nova Aquilae - Der neue Stern von 1918. 12. Der Krebs-Nebel - Die Supernova des Jahres 1054. 13. Die Hyaden und Plejaden - Sternhaufen. 14. Die Milchstraße - Unsere Galaxis. 15. Die Magellanschen Wolken - Unsere Nachbarn im Weltall. 16. Der Andromeda-Nebel - Zwilling unserer Galaxis. 17. Messier 87 - Eine Radiogalaxie. 18. 3C 273 - Rätselhafter Quasar. 19. Messier 82 - Eine "Starburst"-Galaxie. 20. Der Virgo-Haufen - Ein reicher Galaxienhaufen. 21. Das Universum.

  11. On the Issue of Excess Lower Stratospheric Subtropical Transport in GEOS-DAS

    NASA Technical Reports Server (NTRS)

    Tan, Wei-Wu; Geller, Marvin; Pawson, Steven

    2002-01-01

    In recent years, data assimilation has become an indispensable tool for our understanding of the global features of meteorological variables. However, assessments of transport characteristics using trajectory related methods as well as chemical transport models (CTMs) show that results derived from assimilated (or analyzed) winds exhibit significantly larger mixing and entrainment rates compared to results derived from GCM winds, which are closer to results derived from observations (e.g., Douglass et al., 2002; Schoeberl et al., 2002). This discrepancy presents a serious challenge to our ability to understand and model global trace gas transport and distribution. We use the GEOS-DAS to explore this issue by examining how the process of data assimilation alters the dynamics of the underlying GCM and how this leads to the excess of lower stratospheric mixing and transport in the subtropics. In particular, we show that significant model biases in tropical winds necessitate large analysis increments. These increments directly force large subtropical regions of instability with negative PV gradient on the one hand, and generate excessive noise in the tropical wind fields on the other. The result is an excess of transport in the lower stratospheric subtropics.

  12. Ventos em supergigantes B[e] das nuvens de Magalhes e da Galxia

    NASA Astrophysics Data System (ADS)

    de Arajo, F. X.; Pilling, D. A.; Pereira, C. B.; Fernandes, M. B.

    2003-08-01

    As Supergigantes B[e] apresentam as seguintes caractersticas: (i) alta luminosidade; (ii) espectro tpico de estrelas de tipo B; (iii) linhas permitidas e proibidas em emisso de metais de baixa ionizao, especialmente FeII; (iv) linhas de Balmer, e por vzes tambm dos ions HeI e FeII, com perfis tipo P Cygni indicativos de altas taxas de perda de massa. Atualmente estamos desenvolvendo um projeto que visa comparar as propriedades fisicas (principalmente e v) dos ventos destes objetos nas Nuvens de Magalhes e na Galaxia. O objetivo estudar a influncia da metalicidade. No presente painel apresentamos uma determinao das velocidades terminais de 11 estrelas, sendo 4 na GNM (Hen S111, 66, R126 e Hen S93), 4 na PNM (Hen S18, S23, S65 e R4) e 3 na Galaxia (CPD-529243, MWC 300 e GG Car). Nossos dados so espectros de alta resoluo obtidos no telescpio 1.52m do ESO com o espectrgrafo FEROS. Para determinar as velocidades terminais usamos as linhas Hd e HeI 3888 cujas componentes em absoro costumam estar livres de "blends" e estruturas. Nossos resultados sugerem que as velocidades de expanso na GNM so maiores (ainda que apenas ligeiramente) do que aquelas da PNM, como esperado. No entanto, os objetos da Galaxia no parecem seguir a mesma tendncia.

  13. Common Data Acquisition Systems (DAS) Software Development for Rocket Propulsion Test (RPT) Test Facilities

    NASA Technical Reports Server (NTRS)

    Hebert, Phillip W., Sr.; Davis, Dawn M.; Turowski, Mark P.; Holladay, Wendy T.; Hughes, Mark S.

    2012-01-01

    The advent of the commercial space launch industry and NASA's more recent resumption of operation of Stennis Space Center's large test facilities after thirty years of contractor control resulted in a need for a non-proprietary data acquisition systems (DAS) software to support government and commercial testing. The software is designed for modularity and adaptability to minimize the software development effort for current and future data systems. An additional benefit of the software's architecture is its ability to easily migrate to other testing facilities thus providing future commonality across Stennis. Adapting the software to other Rocket Propulsion Test (RPT) Centers such as MSFC, White Sands, and Plumbrook Station would provide additional commonality and help reduce testing costs for NASA. Ultimately, the software provides the government with unlimited rights and guarantees privacy of data to commercial entities. The project engaged all RPT Centers and NASA's Independent Verification & Validation facility to enhance product quality. The design consists of a translation layer which provides the transparency of the software application layers to underlying hardware regardless of test facility location and a flexible and easily accessible database. This presentation addresses system technical design, issues encountered, and the status of Stennis development and deployment.

  14. An initial test of an Intelligent Distributed Acoustic Sensing (iDAS) in the ice in Lake Mendota

    NASA Astrophysics Data System (ADS)

    Castongia, E.; Fratta, D.; Wang, H. F.; Mondanos, M.; Chalari, A.

    2013-12-01

    A Distributed Acoustic Sensor (DAS) was deployed to assess wave propagation detection in ice using fiber-optic cable. The acoustic field is sensed continuously along an optical fiber cable by interrogating it with pulses of light. The Sensor (iDAS manufactured by Silixa) samples the coupled medium as to the fiber, as waves travel through the medium, at several kilohertz along every meter of the cable. In March 2012 measurements were carried out along a triangular shaped array on the frozen surface of Lake Mendota. The purpose of the test was to assess the applicability of DAS to determine near surface geophysical properties from its unique way of measuring acoustic fields. We constructed an equilateral triangle array with a side length of 30 meters by freezing optical fiber cables into the sub surface layer of the ice which ranged in thickness between 15 to 20 cm. The fiber cables were frozen to a depth of about 10 cm to achieve uniform cable-ice coupling. The cable sensor was continuous and was looped about 4 times around to get multiple readings at each sampling location, and resulted in a total cable length of about 445 meters. Two different cable constructions were tested. The first type was of tight-buffered central stainless steel capillary tube and the second type of steel-reinforced central stainless steel loose tube. Seismic shots were generated using a sledge hammer and steel plate. Various shot sequences were taken along three different directions to assess the response and sensitivity of the system. A vertical geophone array was also deployed for a reference measurement every 5 meters along each of the sides of the triangle. Every 10 meters, the vertical geophones were complemented by two horizontal geophones. Analysis of the data showed that wavefronts of first arrivals were clearly visible from even the furthest shot location which enabled calculations of properties of the ice as the wavefronts traveled through it. Differences in sign in the recorded amplitude from various shot locations suggest a near field and far field recording difference for iDAS. The iDAS response along different directions of fiber was examined to determine any directional sensitivity to help with future array designs. This set of tests provided valuable insight into the applicability of the system and array designs for future deployment along with other potential applications we hope to use iDAS for.

  15. MoSST DAS: The First Working Geomagnetic Data Assimilation System

    NASA Technical Reports Server (NTRS)

    Kuang, Weijia; Wei, Zigang; Tangborn, Andrew

    2011-01-01

    The Earth possesses an internal magnetic field (geomagnetic field) generated by convection in the outer core (geodynamo). Previous efforts have been focused along two distinct paths: (1) numerical geodynamo modeling to understand the origin of the geomagnetic field, and the mechanisms of geomagnetic secular variations (SV); and (2) geomagnetic field modeling to map the spatial/temporal variations of the field from geomagnetic data, and to derive core properties, e.g. inversion of core flow near the core-mantle boundary (CMB). Geomagnetic data assimilation is a new approach emerged over the past 5 years: surface observations are assimilated with geodynamo models for better understanding of the core dynamical state, and accurately prediction of SV. In collaboration with several geomagnetic research groups, we have developed the first working geomagnetic data assimilation system, Modular, Scalable, Self-consistent, and Three-dimensional (MoSST) DAS, that includes the MoSST numerical dynamo model; 7000 years of geomagnetic field maps from several field models utilizing satellite and ground observatory data, historical magnetic records and archeo/paleo magnetic data; and an ensemble based optimal interpolation (01) assimilation algorithm. With this system, we have demonstrated clearly that the assimilated core dynamical state is substantially different from those of pure geodynamo simulations. Ensemble assimilation runs also show the convergence of the assimilated solutions inside the core, suggesting that the simulation state is pulled closer to the truth via data assimilation. The forecasts from this system are also very accurate: the 5-year forecast of the geomagnetic field agrees very well with the observations; and the 5-year secular variation forecast is more accurate than the IGRF SV forecast models in the past. Using geomagnetic records up to 2009, we have made an SV forecast for the period from 2010-2015, and is a candidate SV model for IGRF-11.

  16. Alice Vance ("Das Bärenweib"): a historical case of Nievergelt syndrome.

    PubMed

    Urban, M; Krüger, S

    1998-03-01

    Several malformed individuals were presented at the World Exhibition in Antwerp in 1894. Among them was Mrs. Alice Vance from Mount Pleasant, Texas, with congenital limb defects, and Mr. Eugen Berry, who had asymmetrical, monstrous enlargement and macrodactyly of the feet, i.e., Proteus syndrome. After the World Exhibition Mrs. Vance presented herself to the public in Castan's Panopticon imitating a bear. She became famous under the stage name "Das Bärenweib" ("the bear-like woman") and was examined by several German clinicians, and her malformations were considered to be of high scientific interest. Mrs. Vance had mesomelic dwarfism and her mother was known to have similar malformations. Her limb deficiencies were generally considered a unique congenital condition those days, and the diagnosis of "a maternally inherited malformation of the forearms and the shanks" [Daffner 1898: Munch Med Wochenschr 25:782] was made. Virchow [1897: Verh Berl Ges Ethnol Urgeschichte 29:624], feeling attacked by a daily newspaper stating that the physicians as well as the police of Berlin had missed the diagnosis of an "English disease," eventually exercised his authority and diagnosed Alice Vance as a "phocomelic." Clearly, she was not a phocomelic according to past and current definition of this term. Thus, from a historical point of view, the story illustrates how pressure from the daily press altered the definition of an up-to-then precisely defined medical term for decades. According to the clinical data and an X-ray report available from the literature, Alice Vance had a dominantly inherited type of mesomelic dwarfism. We propose the diagnosis of Nievergelt syndrome. PMID:9511977

  17. MiDas: automatic extraction of a common domain of discourse in sleep medicine for multi-center data integration.

    PubMed

    Sahoo, Satya S; Ogbuji, Chimezie; Luo, Lingyun; Dong, Xiao; Cui, Licong; Redline, Susan S; Zhang, Guo-Qiang

    2011-01-01

    Clinical studies often use data dictionaries with controlled sets of terms to facilitate data collection, limited interoperability and sharing at a local site. Multi-center retrospective clinical studies require that these data dictionaries, originating from individual participating centers, be harmonized in preparation for the integration of the corresponding clinical research data. Domain ontologies are often used to facilitate multi-center data integration by modeling terms from data dictionaries in a logic-based language, but interoperability among domain ontologies (using automated techniques) is an unresolved issue. Although many upper-level reference ontologies have been proposed to address this challenge, our experience in integrating multi-center sleep medicine data highlights the need for an upper level ontology that models a common set of terms at multiple-levels of abstraction, which is not covered by the existing upper-level ontologies. We introduce a methodology underpinned by a Minimal Domain of Discourse (MiDas) algorithm to automatically extract a minimal common domain of discourse (upper-domain ontology) from an existing domain ontology. Using the Multi-Modality, Multi-Resource Environment for Physiological and Clinical Research (Physio-MIMI) multi-center project in sleep medicine as a use case, we demonstrate the use of MiDas in extracting a minimal domain of discourse for sleep medicine, from Physio-MIMI's Sleep Domain Ontology (SDO). We then extend the resulting domain of discourse with terms from the data dictionary of the Sleep Heart and Health Study (SHHS) to validate MiDas. To illustrate the wider applicability of MiDas, we automatically extract the respective domains of discourse from 6 sample domain ontologies from the National Center for Biomedical Ontologies (NCBO) and the OBO Foundry. PMID:22195180

  18. Sensitivity of Global Modeling Initiative CTM predictions of Antarctic ozone recovery to GCM and DAS generated meteorological fields

    SciTech Connect

    Rotman, D; Bergmann, D

    2003-12-04

    We use the Global Modeling Initiative chemistry and transport model to simulate the evolution of stratospheric ozone between 1995 and 2030, using boundary conditions consistent with the recent World Meteorological Organization ozone assessment. We compare the Antarctic ozone recovery predictions of two simulations, one driven by meteorological data from a general circulation model (GCM), the other using the output of a data assimilation system (DAS), to examine the sensitivity of Antarctic ozone recovery predictions to the characteristic dynamical differences between GCM and DAS-generated meteorological data. Although the age of air in the Antarctic lower stratosphere differs by a factor of 2 between the simulations, we find little sensitivity of the 1995-2030 Antarctic ozone recovery between 350 K and 650 K to the differing meteorological fields, particularly when the recovery is specified in mixing ratio units. Relative changes are smaller in the DAS-driven simulation compared to the GCM-driven simulation due to a surplus of Antarctic ozone in the DAS-driven simulation which is not consistent with observations. The peak ozone change between 1995 and 2030 in both simulations is {approx}20% lower than photochemical expectations, indicating that changes in ozone transport at 450 K between 1995 and 2030 constitute a small negative feedback. Total winter/spring ozone loss during the base year (1995) of both simulations and the rate of ozone loss during August and September is somewhat weaker than observed. This appears to be due to underestimates of Antarctic Cl{sub y} at the 450 K potential temperature level.

  19. A novel abundant family of retroposed elements (DAS-SINEs) in the nine-banded armadillo (Dasypus novemcinctus).

    PubMed

    Churakov, Gennady; Smit, Arian F A; Brosius, Jrgen; Schmitz, Jrgen

    2005-04-01

    About half of the mammalian genome is composed of retroposons. Long interspersed elements (LINEs) and short interspersed elements (SINEs) are the most abundant repetitive elements and account for about 21% and 13% of the human genome, respectively. SINEs have been detected in all major mammalian lineages, except for the South American order Xenarthra, also termed Edentata (armadillos, anteaters, and sloths). Investigating this order, we discovered a novel high-copy-number family of tRNA derived SINEs in the nine-banded armadillo Dasypus novemcinctus, a species that successfully crossed the Central American land bridge to North America in the Pliocene. A specific computer algorithm was developed, and we detected and extracted 687 specific SINEs from databases. Termed DAS-SINEs, we further divided them into six distinct subfamilies. We extracted tRNA(Ala)-derived monomers, two types of dimers, and three subfamilies of chimeric fusion products of a tRNA(Ala) domain and an approximately 180-nt sequence of thus far unidentified origin. Comparisons of secondary structures of the DAS-SINEs' tRNA domains suggest selective pressure to maintain a tRNA-like D-arm structure in the respective founder RNAs, as shown by compensatory mutations. By analysis of subfamily-specific genetic variability, comparison of the proportion of direct repeats, and analysis of self-integrations as well as key events of dimerization and deletions or insertions, we were able to delineate the evolutionary history of the DAS-SINE subfamilies. PMID:15616140

  20. A new combined integral-light and slit-scan data analysis system (DAS) for flow cytometry.

    PubMed

    Beisker, W

    1994-02-01

    Flow cytometry using list mode parameters such as fluorescence emission, light scatter and size on one hand and different slit-scan parameters on the other hand needs a fast, flexible, efficient and easy-to-use data analysis software. A new software package (data analysis system, DAS) has been developed that integrates data analysis for conventional (integral-light) flow cytometry and for slit-scan flow cytometry. The requirements, design and some examples are discussed and an implementation for IBM-compatible computers is presented. Special attention is directed to the handling of different data types from one-parameter histograms to multiparameter slit-scan data files. The package can be used as an interpreting programming language or as an interactive menu-driven command line interpreter with a large number of graphic, mathematical and statistical functions. DAS is not limited to use in flow cytometry only, but multidimensional data analysis, from astronomy to economics, can be done as well. PMID:8194305

  1. Insect-protected event DAS-81419-2 soybean (Glycine max L.) grown in the United States and Brazil is compositionally equivalent to nontransgenic soybean.

    PubMed

    Fast, Brandon J; Schafer, Ariane C; Johnson, Tempest Y; Potts, Brian L; Herman, Rod A

    2015-02-25

    The transgenic soybean event DAS-81419-2 contains genes that encode the Cry1F, Cry1Ac, and PAT proteins. Cry1F and Cry1Ac provide protection against key lepidopteran insect pests, while PAT confers tolerance to the herbicide glufosinate. To satisfy regulatory requirements for the safety evaluation of transgenic crops, studies were conducted in the United States and Brazil to evaluate the nutrient and antinutrient composition of event DAS-81419-2 soybean. On the basis of the results of these studies, event DAS-81419-2 soybean is compositionally equivalent to nontransgenic soybean. This conclusion concurs with numerous other published studies in soybean and other crops where compositional equivalence between the transgenic crop and its nontransgenic comparator has been demonstrated. PMID:25641393

  2. Insect-Protected Event DAS-81419-2 Soybean (Glycine max L.) Grown in the United States and Brazil Is Compositionally Equivalent to Nontransgenic Soybean

    PubMed Central

    2015-01-01

    The transgenic soybean event DAS-81419-2 contains genes that encode the Cry1F, Cry1Ac, and PAT proteins. Cry1F and Cry1Ac provide protection against key lepidopteran insect pests, while PAT confers tolerance to the herbicide glufosinate. To satisfy regulatory requirements for the safety evaluation of transgenic crops, studies were conducted in the United States and Brazil to evaluate the nutrient and antinutrient composition of event DAS-81419-2 soybean. On the basis of the results of these studies, event DAS-81419-2 soybean is compositionally equivalent to nontransgenic soybean. This conclusion concurs with numerous other published studies in soybean and other crops where compositional equivalence between the transgenic crop and its nontransgenic comparator has been demonstrated. PMID:25641393

  3. PET imaging of demyelination and remyelination in the cuprizone mouse model for multiple sclerosis: a comparison between [11C]CIC and [11C]MeDAS.

    PubMed

    de Paula Faria, Daniele; de Vries, Erik F J; Sijbesma, Jurgen W A; Dierckx, Rudi A J O; Buchpiguel, Carlos A; Copray, Sjef

    2014-02-15

    Multiple Sclerosis (MS) is a neurodegenerative disease characterized by demyelinated lesions. PET imaging using specific myelin radioligands might solve the lack of a specific imaging tool for diagnosing and monitoring demyelination and remyelination in MS patients. In recent years, a few tracers have been developed for in vivo PET imaging of myelin, but they have not been fully evaluated yet. In this study, we compared [(11)C]CIC and [(11)C]MeDAS as PET tracers for monitoring demyelination and remyelination in cuprizone-fed mice. The ex vivo biodistribution of [(11)C]CIC showed decreased tracer uptake in mice fed with 0.2% cuprizone diet for 5 weeks, as compared to control mice. However, tracer uptake did not increase again after normal diet was restored for 5 weeks (remyelination). Surprisingly, in vivo PET imaging with [(11)C]CIC in cuprizone-fed mice revealed a significant reduction in whole brain tracer uptake after 5 weeks of remyelination. No correlation between ex vivo biodistribution and in vivo imaging data was found for [(11)C]CIC (r(2)=0.15, p=0.11). However, a strong correlation was found for [(11)C]MeDAS (r(2)=0.88, p<0.0001). [(11)C]MeDAS ex vivo biodistribution revealed significant decreased brain uptake in the demyelination group, as compared to controls and increased the tracer uptake after 5 weeks of remyelination. [(11)C]MeDAS images showed a low background signal and clear uptake in the brain white matter and spinal cord. Taken together, the results of this comparative study between [(11)C]CIC and [(11)C]MeDAS clearly show that [(11)C]MeDAS is the preferred PET tracer to monitor myelin changes in the brain and spinal cord in vivo. PMID:24188813

  4. Taxonomic notes and distribution extension of Durga Dass leaf-nosed bat Hipposideros durgadasi Khajuria, 1970 (Chiroptera: Hipposideridae) from south India

    PubMed Central

    Kaur, Harpreet; Srinivasulu, Bhargavi; Shah, Tariq Ahmed; Devender, Gundena; Srinivasulu, Aditya

    2014-01-01

    Abstract Durga Dass leaf-nosed bat Hipposideros durgadasi Khajuria, 1970 is endemic to India, and was known only from Katanga, Katangi, and Richhai villages, in Jabalpur district, Madhya Pradesh. During surveys conducted in Kolar district, Karnataka, India, we successfully mist-netted a few individuals belonging to the bicolor species group which, upon detailed external, craniodental and bacular studies were identified as Durga Dass leaf-nosed bat. This paper reports the presence of this species in southern India, extending its distribution range by almost 1300 km. We also provide a detailed morphological description for this species. PMID:25535483

  5. Compositional equivalence of DAS-444Ø6-6 (AAD-12 + 2mEPSPS + PAT) herbicide-tolerant soybean and nontransgenic soybean.

    PubMed

    Lepping, Miles D; Herman, Rod A; Potts, Brian L

    2013-11-20

    Soybeans from transgenic event DAS-444Ø6-6 are the first to express three proteins that provide tolerance to broad-spectrum herbicides. DAS-444Ø6-6 soybean expresses the aryloxyalkanoate dioxygenase-12 (AAD-12) enzyme from the soil bacterium Delftia acidovorans , which provides tolerance to the herbicide 2,4-dichlorophenoxyacetic acid (2,4-D); the double-mutant 5-enolpyruvylshikimate-3-phosphate synthase (2mEPSPS) enzyme encoded by a modified version of the epsps gene from maize ( Zea mays ), which provides tolerance to the herbicide glyphosate; and the phosphinothricin acetyltransferase (PAT) enzyme from Streptomyces viridochromogenes , which provides tolerance to the herbicide glufosinate. The purpose of this study was to determine if the nutrient and antinutrient composition of forage and grain from DAS-444Ø6-6 soybean are similar to those of nontransgenic soybean. Forage was analyzed for proximates, fiber, and minerals; grain analyses further included vitamins, amino acid and fatty acid profiles, and antinutrients and bioactive components (lectin, phytic acid, raffinose, stachyose, trypsin inhibitor, and isoflavones). Results indicate that DAS-444Ø6-6 soybean is compositionally equivalent to nontransgenic soybean. Findings are consistent with similar studies for other input traits, as endogenous plant metabolic pathways that influence composition are expected to be less affected by transgenesis compared with traditional plant-breeding methods. PMID:24191699

  6. Development of a surface-wave imaging system for geotechnical applications based on distributed acoustic sensing (DAS) and ambient noise interferometry

    NASA Astrophysics Data System (ADS)

    Ajo Franklin, J. B.; Daley, T. M.; Freifeld, B. M.; Tang, D. G.; Zhang, R.; Wagner, A. M.; Dou, S.; Lindsey, N.; Bjella, K.; Pevzner, R.

    2014-12-01

    Distributed fiber-optic sensing methods have been used since the 1980's for continuous monitoring of near-surface soil properties, typically exploiting Raman scattering to measure temperature (DTS) or stimulated Brillouin scattering to measure strain (DSS). Recent advances in high speed measurement of Rayleigh scattering has enabled distributed recording of seismic waves over long sections of fiber; this approach, referred to as distributed acoustic sensing (DAS) has the potential to allow nearly continuous monitoring of near-surface mechanical properties, a crucial target for geotechnical management of infrastructure dependent on soil strength. We present initial results from our effort to build a real-time soil property monitoring system based on DAS; our approach employs seismic interferometry and dispersion analysis of ambient noise generated by infrastructure to provide a continuously updated model of shear modulus. Our preliminary results include an in-depth investigation of DAS fiber response in the context of active sources; this component of our study verifies classical models for the azimuthal response of straight fibers to propagating surface waves. We also explore the "noisescape" of linear infrastructure and show a usable seismic signal band of 8-40 hz at a series of sites, primarily consisting of Rayleigh waves. Finally, we present preliminary results from a DAS monitoring array installed at the Richmond Field Station near a heavily used road and compare interferometric processing of the acquired data to that generated by surface deployment of geophones.

  7. Das Lektin aus der Erbse Pisum sativum : Bindungsstudien, Monomer-Dimer-Gleichgewicht und Rückfaltung aus Fragmenten

    NASA Astrophysics Data System (ADS)

    Küster, Frank

    2002-11-01

    Das Lektin aus Pisum sativum, der Gartenerbse, ist Teil der Familie der Leguminosenlektine. Diese Proteine haben untereinander eine hohe Sequenzhomologie, und die Struktur ihrer Monomere, ein all-ß-Motiv, ist hoch konserviert. Dagegen gibt es innerhalb der Familie eine große Vielfalt an unterschiedlichen Quartärstrukturen, die Gegenstand kristallographischer und theoretischer Arbeiten waren. Das Erbsenlektin ist ein dimeres Leguminosenlektin mit einer Besonderheit in seiner Struktur: Nach der Faltung in der Zelle wird aus einem Loop eine kurze Aminosäuresequenz herausgeschnitten, so dass sich in jeder Untereinheit zwei unabhängige Polypeptidketten befinden. Beide Ketten sind aber stark miteinander verschränkt und bilden eine gemeinsame strukturelle Domäne. Wie alle Lektine bindet Erbsenlektin komplexe Oligosaccharide, doch sind seine physiologische Rolle und der natürliche Ligand unbekannt. In dieser Arbeit wurden Versuche zur Entwicklung eines Funktionstests für Erbsenlektin durchgeführt und seine Faltung, Stabilität und Monomer-Dimer-Gleichgewicht charakterisiert. Um die spezifische Rolle der Prozessierung für Stabilität und Faltung zu untersuchen, wurde ein unprozessiertes Konstrukt in E. coli exprimiert und mit der prozessierten Form verglichen. Beide Proteine zeigen die gleiche kinetische Stabilität gegenüber chemischer Denaturierung. Sie denaturieren extrem langsam, weil nur die isolierten Untereinheiten entfalten können und das Monomer-Dimer-Gleichgewicht bei mittleren Konzentrationen an Denaturierungsmittel auf der Seite der Dimere liegt. Durch die extrem langsame Entfaltung zeigen beide Proteine eine apparente Hysterese im Gleichgewichtsübergang, und es ist nicht möglich, die thermodynamische Stabilität zu bestimmen. Die Stabilität und die Geschwindigkeit der Assoziation und Dissoziation in die prozessierten bzw. nichtprozessierten Untereinheiten sind für beide Proteine gleich. Darüber hinaus konnte gezeigt werden, dass auch unter nicht-denaturierenden Bedingungen die Untereinheiten zwischen den Dimeren ausgetauscht werden. Die Renaturierung der unprozessierten Variante ist unter stark nativen Bedingungen zu 100 % möglich. Das prozessierte Protein dagegen renaturiert nur zu etwa 50 %, und durch die Prozessierung ist die Faltung stark verlangsamt, der Faltungsprozess ist erst nach mehreren Tagen abgeschlossen. Im Laufe der Renaturierung wird ein Intermediat populiert, in dem die längere der beiden Polypeptidketten ein Homodimer mit nativähnlicher Untereinheitenkontaktfläche bildet. Der geschwindigkeitsbestimmende Schritt der Renaturierung ist die Assoziation der entfalteten kürzeren Kette mit diesem Dimer. The lectin from Pisum sativum (garden pea) is a member of the family of legume lectins. These proteins share a high sequence homology, and the structure of their monomers, an all-ß-motif, is highly conserved. Their quaternary structures, however, show a great diversity which has been subject to cristallographic and theoretical studies. Pea lectin is a dimeric legume lectin with a special structural feature: After folding is completed in the cell, a short amino acid sequence is cut out of a loop, resulting in two independent polypeptide chains in each subunit. Both chains are closely intertwined and form one contiguous structural domain. Like all lectins, pea lectin binds to complex oligosaccharides, but its physiological role and its natural ligand are unknown. In this study, experiments to establish a functional assay for pea lectin have been conducted, and its folding, stability and monomer-dimer-equilibrium have been characterized. To investigate the specific role of the processing for stability and folding, an unprocessed construct was expressed in E. coli and compared to the processed form. Both proteins have the same kinetic stability against chemical denaturant. They denature extremely slowly, because only the isolated subunits can unfold, and the monomer-dimer-equilibrium favors the dimer at moderate concentrations of denaturant. Due to the slow unfolding, both proteins exhibit an apparent hysteresis in the denaturation transition. Therefore it has not been possible to determine their thermodynamic stability. For both proteins, the stability and the rates of association and dissociation into processed or unprocessed subunits, respectively, are equal. Furthermore it could be shown that even under non-denaturing conditions the subunits are exchanged between dimers. Renaturation of the unprocessed variants is possible under strongly native conditions with 100 % yield. The processed protein, however, can be renatured with yields of about 50 %, and its refolding is strongly decelerated. The folding process is finished only after several days. During renaturation, an intermediate is populated, in which the longer of the two polypeptide chains forms a homodimer with a native-like subunit interface. The rate limiting step of renaturation is the association of the unfolded short chain with this dimer.

  8. Free convection in a parallelogrammic porous cavity filled with a nanofluid using Tiwari and Das' nanofluid model.

    PubMed

    Ghalambaz, Mohammad; Sheremet, Mikhail A; Pop, Ioan

    2015-01-01

    The free convection heat transfer of Cu-water nanofluids in a parallelogrammic enclosure filled with porous media is numerically analyzed. The bottom and top of the enclosure are insulated while the sidewalls are subject to limited temperature difference. The Darcy flow and the Tiwari and Das' nanofluid models are considered. The governing dimensionless partial differential equations are numerically solved using a finite difference code. The results are reported for isotherms and streamlines as well as Nusselt number as a function of the volume fraction of nanoparticles, porosity, types of the porous matrix, inclination angle, aspect ratio and different Rayleigh numbers. It is found that the presence of the nanoparticles inside the enclosure deteriorates the heat transfer rate, which is caused due to the increase of dynamic viscosity by the presence of nanoparticles. Therefore, in applications in which the nanofluids are used for their advantages, such as enhanced dielectric properties or antibacterial properties, more caution for the heat transfer design of the enclosure is necessary. PMID:25993540

  9. Common Data Acquisition Systems (DAS) Software Development for Rocket Propulsion Test (RPT) Test Facilities - A General Overview

    NASA Technical Reports Server (NTRS)

    Hebert, Phillip W., Sr.; Hughes, Mark S.; Davis, Dawn M.; Turowski, Mark P.; Holladay, Wendy T.; Marshall, PeggL.; Duncan, Michael E.; Morris, Jon A.; Franzl, Richard W.

    2012-01-01

    The advent of the commercial space launch industry and NASA's more recent resumption of operation of Stennis Space Center's large test facilities after thirty years of contractor control resulted in a need for a non-proprietary data acquisition system (DAS) software to support government and commercial testing. The software is designed for modularity and adaptability to minimize the software development effort for current and future data systems. An additional benefit of the software's architecture is its ability to easily migrate to other testing facilities thus providing future commonality across Stennis. Adapting the software to other Rocket Propulsion Test (RPT) Centers such as MSFC, White Sands, and Plumbrook Station would provide additional commonality and help reduce testing costs for NASA. Ultimately, the software provides the government with unlimited rights and guarantees privacy of data to commercial entities. The project engaged all RPT Centers and NASA's Independent Verification & Validation facility to enhance product quality. The design consists of a translation layer which provides the transparency of the software application layers to underlying hardware regardless of test facility location and a flexible and easily accessible database. This presentation addresses system technical design, issues encountered, and the status of Stennis' development and deployment.

  10. Das Ende der Nacht

    NASA Astrophysics Data System (ADS)

    Posch, Thomas; Freyhoff, Anja; Uhlmann, Thomas

    2009-11-01

    The book provides a comprehensive compilation of the problems arising from artificial lighting and its almost exponential increase during the past century. It covers the following topics: A brief history of Lighting; light pollution in Central Europe; Moths and artificial lights; Artificial lighting and migratory birds; Ocean turtles as victims of beach lighting; Moon light as external timer for the marine fauna; Artificial light and the health of human beings.

  11. Código para imageamento indireto de estrelas em sistemas binarios: simulação de variações elipsoidais e do perfil das linhas

    NASA Astrophysics Data System (ADS)

    Souza, T. R.; Baptista, R.

    2003-08-01

    As estrelas secundárias em variáveis cataclí smicas (VCs) e binárias-x de baixa massa (BXBMs) são cruciais para o entendimento da origem, evolução e comportamento destas binárias interagentes. Elas são estrelas magneticamente ativas submetidas a condições ambientais extremas [e.g., estão muito próximas de uma fonte quente e irradiante; têm rotação extremamente rápida e forma distorcida; estão perdendo massa a taxas de 10-8-10-10 M¤/ano] que contribuem para que suas propriedades sejam distintas das de estrelas de mesma massa na seqüência principal. Por outro lado, o padrão de irradiação na face da secundária fornece informação sobre a geometria das estruturas de acréscimo em torno da estrela primária. Assim, a obtenção de imagens da superfície destas estrelas é de grande interesse astrofísico. A Tomografia Roche usa as variações no perfil das linhas de emissão/absorção da estrela secundária em função da fase orbital para mapear a distribuição de brilho em sua superfície. Neste trabalho apresentamos os resultados iniciais do desenvolvimento de um programa para o mapeamento da distribuição de brilho na superfí cie das estrelas secundárias em VCs e BXBMs com técnicas de astro-tomografia. Presentemente temos em operação um código que simula as variações no perfil das linhas em conseqüência de efeito Doppler resultante da combinação de rotação e translação de uma estrela em forma de lobo de Roche em torno do centro de massa da binária, em função da distribuição de brilho na superfície desta estrela. O código igualmente produz a curva de luz resultante das variações de aspecto da estrela em função da fase orbital (variações elipsoidais).

  12. Variation of the anthropic vulnerability in Ribeirão das Pedras watershed in Campinas/SP - Brazil.

    NASA Astrophysics Data System (ADS)

    Damame, Desirée; Longo, Regina; Ribeiro, Admilson; Fengler, Felipe

    2015-04-01

    The human actions has caused over the years profound changes in environmental quality in urban ecosystems suffering losses in the quality of air, soil , water and vegetation also the quality of life of the population that inhabit these areas . The study area is characterized by being a highly urbanized watershed, with about 43 % of its area covered by buildings, houses , and commercial and industrial establishments . Called the Ribeirão das Pedras Basin, located in Campinas / SP - Brazil and is bounded by coordinates 22˚47'10 '' and 22˚52'20 '' S , and 47˚ 07'15 '' and 46˚ 02 ' 15' ' . Has an average temperature of 22.4 ° C and average annual rainfall of 1424.5 mm . It has an area of about 42 km² . This is located two universities and a large mall. It also demands a strong agriculture , which occupies about 30 % of the area . It has also been part of two major forest reserves of the municipality, the Forest Santa Geneva and the Forest of Quilombo , both added to other small fragments overlying only about 6% of the total basin area . Avalição to environmental quality , the analysis of the vulnerability of urban watershed becomes an important environmental management tool. The vulnerability can be defined by susceptibility to changes of environment in its initial state , a current tax status by human intervention , and is almost always associated with risk , and the intensity at which such projects in one place, person or structure. In this context , this study aimed to assess environmental vulnerability in an urban watershed coming under increasing human pressures , especially in recent years . For this analysis were prepared soil graphics, slope , elevation and land use and land cover for the years 2009 and 2014 , generating with these , comparative anthropic vulnerability maps of the past five years. Crafting vulnerability maps is a sensitivity in order to enable appropriate management of biotic systems. With the results can be seen that the variation of anthropogenic vulnerability in the study area took place mainly by the real estate growth that the area has suffered in recent years, due to the large enhancement of the region , both for businesses and homes , as for industrial area. It was found that the distribution of anthropogenic vulnerability for 2009 was 19% too low, 33% low, 40 % moderate , high 8% and 0% too high. 2014 was obtained by dividing the current scenario is as follows: 10% very low , low 31% , moderate 50% , 9% and 0% high too high, meaning that there was an increase in high vulnerability points and moderate and still , a very significant decrease for low and very low vulnerability , revealing the strong environmental impact that the area has been suffering . Thus, we can conclude that the housing boom in large areas impacts the vulnerability of a watershed , which will certainly affect both the areas of forest / native fragments , and subsequently the quality of life of the surrounding population. In the specific case of Ribeirão das Pedras watershed , knowing the strong agricultural occupation of the area , it is known that the increased fragility still imply large losses for food production in the region.

  13. The geology of the Morro Velho gold deposit in the Archean Rio das Velhas greenstone belt, Quadriltero Ferrfero, Brazil

    USGS Publications Warehouse

    Vial, Diogenes Scipioni; DeWitt, Ed; Lobato, Lydia Maria; Thorman, Charles H.

    2007-01-01

    The Morro Velho gold deposit, Quadriltero Ferrfero region, Minas Gerais, Brazil, is hosted by rocks at the base of the Archean Rio das Velhas greenstone belt. The deposit occurs within a thick carbonaceous phyllite package, containing intercalations of felsic and intermediate volcaniclastic rocks and dolomites. Considering the temporal and spatial association of the deposit with the Rio das Velhas orogeny, and location in close proximity to a major NNW-trending fault zone, it can be classified as an orogenic gold deposit. Hydrothermal activity was characterized by intense enrichment in alteration zones of carbonates, sulfides, chlorite, white micabiotite, albite and quartz, as described in other Archean lode-type gold ores. Two types of ore occur in the deposit: dark gray quartz veins and sulfide-rich gold orebodies. The sulfide-rich orebodies range from disseminated concentrations of sulfide minerals to massive sulfide bodies. The sulfide assemblage comprises (by volume), on average, 74% pyrrhotite, 17% arsenopyrite, 8% pyrite and 1% chalcopyrite. The orebodies have a long axis parallel to the local stretching lineation, with continuity down the plunge of fold axis for at least 4.8km. The group of rocks hosting the Morro Velho gold mineralization is locally referred to aslapa seca. These were isoclinally folded and metamorphosed prior to gold mineralization. Thelapa secaand the orebodies it hosts are distributed in five main tight folds related to F1 (the best examples are the X, Main and South orebodies, in level 25), which are disrupted by NE- to E-striking shear zones. Textural features indicate that the sulfide mineralization postdated regional peak metamorphism, and that the massive sulfide ore has subsequently been neither metamorphosed nor deformed. Lead isotope ratios indicate a model age of 2.820.05Ga for both sulfide and gold mineralization. Thelapa secaare interpreted as the results of a pre-gold alteration process and may be divided into carbonatic, micaceous and quartzose types. The carbonaticlapa secais subdivided into gray and brown subtypes. Non-mineralized, gray carbonaticlapa secaforms the hanging wall to the orebodies, and is interpreted as the product of extreme CO2metasomatism during hydrothermal alteration. This dolomiticlapa secaranges in composition from relatively pure limestone and dolomite to silty limestone and dolomite. The brown carbonatic and micaceouslapa secasare the host rocks to gold. These units are interpreted to correspond to the sheared and hydrothermal products of metamorphosed volcaniclastic and/or volcanic rocks of varying composition from dacitic to andesitic, forming various types of schists and phyllites. The high-grade, massive sulfide orebodies occur at the base of the gray carbonaticlapa seca. Both disseminated mineralization and quartz veins are hosted by micaceouslapa seca. The data are consistent with a model of epigenetic mineralization for thelapa seca, from a hydrothermal fluid derived in part from the Archean basement or older crust material.

  14. Ultrasound Findings in Hand Joints Involvement in Patients with Psoriatic Arthritis and Its Correlation with Clinical DAS28 Score

    PubMed Central

    Naranje, Priyanka; Prakash, Mahesh; Sharma, Aman; Dogra, Sunil; Khandelwal, Niranjan

    2015-01-01

    Objective. To determine the frequency of the various ultrasound findings in hand joints in patients with psoriatic arthritis and correlate grayscale and Power Doppler ultrasonography findings with Disease Activity Score 28. Methods. This prospective study was performed in 30 patients. Ultrasound evaluation of 28 joints of both hands was undertaken and various findings were recorded including synovial hypertrophy, Power Doppler abnormality, soft tissue thickening, tendonitis, joint effusion, periosteal reaction, and erosions. Composite ultrasound scores and Disease Activity Score 28 were calculated and compared. Spearman correlation was used to see relationship between the ultrasound and DAS28 scores. Results. Ultrasound detected more abnormalities in the hand joints than did clinical examination. The frequency of various ultrasound abnormalities was as follows: Synovial hypertrophy was seen in 100%, Power Doppler abnormality suggesting hypervascularity was seen in 36.7%, soft tissue thickening was seen in 66.7%, periosteal reaction was seen in 33.3%, erosions were seen in 30% (mostly in DIP and PIP joints), and flexor tendonitis was seen in 6.7% of patients. Significant correlation was found between Disease Activity Score 28 and grayscale joint score (GSJS) (Spearman's ρ: 0.499; P: 0.005), grayscale joint count (GSJC) (ρ: 0.398; P: 0.029), and Power Doppler joint score (PDJS) (ρ: 0.367; P: 0.046). There was a statistically significant difference between remission and low disease activity group and moderate disease activity group in terms of GSJC, GSJS, PDJC, and PDJS (P < 0.05). These ultrasound measures were higher in moderate disease activity zone patients. Conclusion. Ultrasound is a useful modality for the objective assessment of psoriatic arthritis. Ultrasound including Power Doppler can be used as a modality for assessment of severity of psoriatic arthritis as it correlates with the clinical scoring. PMID:26858846

  15. Calibration of Helmholtz Coils for the characterization of MEMS magnetic sensor using fluxgate magnetometer with DAS1 magnetic range data acquisition system

    NASA Astrophysics Data System (ADS)

    Ahmad, Farooq; Dennis, John Ojur; Md Khir, Mohd Haris; Hamid, Nor Hisham

    2012-09-01

    This paper presents the calibration of Helmholtz coils for the characterization of MEMS Magnetic sensor using Fluxgate magnetometer with DAS1 Magnetic Range Data Acquisition System. The Helmholtz coils arrangement is often used to generate a uniform magnetic field in space. In the past, standard magnets were used to calibrate the Helmholtz coils. A method is presented here for calibrating these coils using a Fluxgate magnetometer and known current source, which is easier and results in greater accuracy.

  16. Desenvolvimento das câmeras de raios-X duros do satélite MIRAX

    NASA Astrophysics Data System (ADS)

    Braga, J.; Rothschild, R.; Staubert, R.; Heise, J.; Remillard, R.; D'Amico, F.; Jablonski, F.; Mejía, J.; Carvalho, H.; Heindl, B.; Matteson, J.; Kendziorra, E.; Wilms, J.; in't Zand, J.; Kuulkers, E.

    2003-08-01

    O MIRAX (Monitor e Imageador de RAios-X) é um projeto de desenvolvimento de um pequeno satélite astronômico de raios-X (~200 kg, ~240 W). A estratégia básica da missão será observar continuamente (~9 meses por ano) a região central (~1000 graus2) do plano Galáctico e realizar estudos espectroscópicos de banda larga (2-200 keV) e alta sensibilidade de um grande conjunto de fontes através de imagens com resolução de ~6'. Isso proporcionará uma cobertura inédita do "espaço de descobertas" através da detecção, localização, identificação e estudo detalhado de fenômenos imprevisíveis, tais como transientes fracos de raios-X, novas rápidas de raios-X e bursts de raios gama, assim como o estudo de fontes com emissão persistente. Neste trabalho apresentamos o projeto das duas câmeras de raios-X duros (CXDs) do MIRAX, que irão operar na faixa de 10 a 200 keV. Cada CXD consistirá de um plano de detectores CZT (Cd0,9Zn0,1Te) de 0,5 mm de resolução espacial e 370 cm2 de área total, e de uma máscara codificada com elementos quadrados de 1,3 mm de lado e 0,5 cm de espessura. A máscara terá dimensões de 315 cm ´ 275 cm e será montada a 700 cm de distância dos detectores. Com essa configuração as CXDs terão 6' de resolução angular e, quando colocadas a um ângulo de 29° entre si, as duas câmeras propiciam um campo totalmente codificado de 39° ´ 6°12' e um campo total de 76° ´ 44°. Serão apresentadas simulações de observações da região do plano Galáctico com o conjunto formado pelas duas CXDs.

  17. Soil gas Rn monitoring at Chã das Caldeiras prior the 2014-15 Fogo eruption, Cape Verde

    NASA Astrophysics Data System (ADS)

    Padilla, Germán; Barrancos, José; Dionis, Samara; Fernandes, Paulo; Pérez, Nemesio M.; Sagiya, Takeshi; Padrón, Eleazar; Melián, Gladys V.; Hernández, Pedro A.; Silva, Sónia; Pereira, José Manuel; Rodríguez, Fátima; Asensio-Ramos, María; Calvo, David; Semedo, Helio

    2015-04-01

    Since 2007 the ITER-INVOLCAN/UNICV-OVCV/SNPC research team has implemented a geochemical program for the volcanic surveillance of Fogo volcano by means of applying different geochemical methods in a regularly basis (diffuse degassing surveys, fumarole gas sampling, etc.). This program was improved by setting up a geochemical permanent station (CHA01) to perform continuous measurements of soil gas radon (222Rn) and thoron (220Rn) activities at Chã das Caldeiras, more specific in Portela village, since April 20, 2013. Both gases are characterized to ascend towards the surface mainly through cracks or faults via diffusion and/or advection mechanisms dependent of both soil porosity and permeability, which in turn vary as a function of the stress/strain changes at depth. Measurements of 222Rn and 220Rn activities were performed by an alpha-spectrometer after pumping the soil gas from a thermally isolated PVC pipe inserted 1m in the ground. Even though during the study period the recorded data did not show high 222Rn activity values, a change in the temporal evolution of soil gas 222Rn activity was observed. During the first six months, from April to October, 2013, recorded time series of 222Rn and 220Rn activities showed normal background levels with values of 80.5 and 55.2 Bqm-3, respectively. However, from October, 2013, to February, 2014, 222Rn time series showed an increase trend reaching peak values of 396 Bqm-3 and having an average activity of 134 Bqm-3 until the removal of the station on November 25, 2014 due to the potential danger of being destroyed by the lava flows. The observed increase in the soil gas 222Rn activity from October 2013 to February 2014 occurs almost at the same time of slight observed changes in the vertical displacements detected by the geodetic network installed at the Fogo Island by the ITER-INVOLCAN/UNICV-OVCV/SNPC/Nagoya University research team. Since seismic data are not available, we cannot conclude if the observed changes in soil gas 222Rn activity were originated from fracturing of rock and/or from direct magma degassing. The positive temporal correlation between 222Rn/220Rn ratio and 222Rn activity supports the hypothesis that soil 222Rn activity variations acted as a long-term precursory signal of the volcanic unrest. These results show that monitoring soil gas 222Rn, together with other geochemical and geophysical data, can be a useful monitoring tool to detect early warning signals of magma pressurization.

  18. DasPy 1.0 - the Open Source Multivariate Land Data Assimilation Framework in combination with the Community Land Model 4.5

    NASA Astrophysics Data System (ADS)

    Han, X.; Li, X.; He, G.; Kumbhar, P.; Montzka, C.; Kollet, S.; Miyoshi, T.; Rosolem, R.; Zhang, Y.; Vereecken, H.; Franssen, H.-J. H.

    2015-08-01

    Data assimilation has become a popular method to integrate observations from multiple sources with land surface models to improve predictions of the water and energy cycles of the soil-vegetation-atmosphere continuum. Multivariate data assimilation refers to the simultaneous assimilation of observation data from multiple model state variables into a simulation model. In recent years, several land data assimilation systems have been developed in different research agencies. Because of the software availability or adaptability, these systems are not easy to apply for the purpose of multivariate land data assimilation research. We developed an open source multivariate land data assimilation framework (DasPy) which is implemented using the Python script language mixed with the C++ and Fortran programming languages. LETKF (Local Ensemble Transform Kalman Filter) is implemented as the main data assimilation algorithm, and uncertainties in the data assimilation can be introduced by perturbed atmospheric forcing data, and represented by perturbed soil and vegetation parameters and model initial conditions. The Community Land Model (CLM) was integrated as the model operator. The implementation allows also parameter estimation (soil properties and/or leaf area index) on the basis of the joint state and parameter estimation approach. The Community Microwave Emission Modelling platform (CMEM), COsmic-ray Soil Moisture Interaction Code (COSMIC) and the Two-Source Formulation (TSF) were integrated as observation operators for the assimilation of L-band passive microwave, cosmic-ray soil moisture probe and land surface temperature measurements, respectively. DasPy has been evaluated in several assimilation studies of neutron count intensity (soil moisture), L-band brightness temperature and land surface temperature. DasPy is parallelized using the hybrid Message Passing Interface and Open Multi-Processing techniques. All the input and output data flows are organized efficiently using the commonly used NetCDF file format. Online 1-D and 2-D visualization of data assimilation results is also implemented to facilitate the post simulation analysis. In summary, DasPy is a ready to use open source parallel multivariate land data assimilation framework.

  19. Impact of climate change on snow distribution in Japan estimated using data from the remote weather stations (AMeDAS) and Spot VGT

    NASA Astrophysics Data System (ADS)

    Kominami, Y.; Asaoka, Y.; Tsuyama, I.; Tanaka, N.

    2010-12-01

    Change of the amount of snow by climate change is possibly remarkable in Japan, because air temperature is relatively high as snowy area in the world. And the change of the amount of snow cover highly depends on the supply form of precipitation (rain or snow) in winter corresponding to the change of the temperature in addition to the change of precipitation. And vegetation distribution of Japan is highly affected by snow conditions (snow duration and snow accumulation). To evaluate the change of snow condition in Japan climate change, daily change of SWE of 1km mesh was estimated using daily precipitation and air temperature of AMeDAS(Automated Meteorological Data Acquisition System) data. And using this model, changes of SWE and snow cover period were estimated in condition of global warming. Daily air temperature and precipitation on 1km mesh were estimated over all of Japan by interpolation of the AMeDAS data. AMeDAS is a system that observes the temperature and precipitation, etc. per hour automatically in about 1,300 places (about 17km spacing) in Japan. And daily change of SWE of each point was calculated using degree-day method and threshold temperature for the distinction between snow and rain using these data. We used precipitation and air temperature data of AMeDAS for 23 years from 1980 to 2002. Snow melt coefficient and elevation dependency of winter precipitation of each grid were optimized by snow duration estimated using satellite data (S3 index of Spot VGT) from 1990 to 2000 To estimate the change in the snow accumulation for the years from 2031 to 2051 and from 2081 to 2100, we used the climate change scenario of a high-resolution Regional Climate Model with a 20-km mesh size (RCM20) developed at the Meteorological Research Institute based on the Special Report for Emission Scenario (SRES)-A2. Estimated snow duration was evaluated in 10 points of mountainous snow measurement stations. Averaged error was about 4 days from 1980 to 1999. And estimated SWE was evaluated at 14 points in Niigata and Gunma prefecture from 2000 to 2001. Averaged error of SWE was about 32% in this period. Estimated change of SWE and snow cover period according to air temperature rise was remarkable at plain field along Sea of Japan in main land. Estimated decrease of snow cover period in this area was more than 80% in condition from 2 to 3 degrees air temperature rise for the years from 2031 to 2051.

  20. "Es como uno bomba de tiempo [It's like a time bomb]": A Qualitative Analysis of Perceptions of Diabetes Among First-Degree Relatives of Latino Patients With Diabetes.

    PubMed

    Castro-Rivas, Erida; Boutin-Foster, Carla; Milan, Maria; Kanna, Balavenkatesh

    2014-02-01

    Background. The South Bronx, a largely Latino community, has become an epicenter of the diabetes epidemic in New York City. In this community, nondiabetic first-degree relatives of people with diabetes are prime targets for intervention. Therefore, the objective of this study was to explore the knowledge of diabetes and attitudes toward health behavior modification of Latino adults who are first-degree relatives of people with diabetes. Methods. Participants were recruited from three settings in the South Bronx (a community-based organization, a faith-based organization, and a taxi station). The Common Sense Model was used to develop focus-group items. This model provides a framework for exploring illness representations along five domains: identity, cause, consequences, timeline, and perceptions of curability. Responses were transcribed verbatim, and data analysis proceeded in the following order: data immersion, assignment of codes, grouping of key concepts to form categories, and construction of higher-order themes. Results. Of the 115 potential participants identified, 53 were found to be eligible, and 23 of these participated in the focus group. Of these, 20 were Dominicans, 2 were Puerto Ricans, and 1 was Salvadorian. The mean age was 46.39 years, 35% were women, 61% were married, and 26% had less than a high school education. Qualitative analyses resulted in 547 codes that were grouped into 52 concepts, from which 9 categories and 4 overarching themes emerged. The dominant themes were 1) family, genetics, and culture play a major role in the etiology of diabetes; 2) being Latino and having a first-degree relative with diabetes makes getting diabetes inevitable, and, like a time bomb exploding, it is destined to happen; 3) once one develops diabetes, the physical and emotional consequences are devastating and destructive; and 4) diabetes can be "cured" through healthy eating and with insulin. Conclusions.In this study, first-degree relatives of patients with diabetes were knowledgeable about the risks and consequences of diabetes. However, some participants felt that being Latino and having a first-degree relative with diabetes made one destined to have diabetes. Addressing this misperception through culturally tailored interventions has implications for diabetes prevention and may help to stem the diabetes epidemic in Latino communities. PMID:26246756

  1. Relationship between time-integrated disease activity estimated by DAS28-CRP and radiographic progression of anatomical damage in patients with early rheumatoid arthritis

    PubMed Central

    2011-01-01

    Background The main aim of the study was to investigate the relationship between persistent disease activity and radiographic progression of joint damage in early rheumatoid arthritis (ERA). Methods Forty-eight patients with active ERA was assessed every 3 months for disease activity for 3 years. Radiographic damage was measured by the Sharp/van der Heijde method (SHS). The cumulative inflammatory burden was estimated by the time-integrated values (area under the curve-AUC) of Disease Activity Score 28 joint based on C-reactive protein (DAS28-CRP) in rapid progressors versus non-progressors. Bland and Altman's 95% limits of agreement method were used to estimate the smallest detectable difference (SDD) of radiographic progression. The relationship between clinical and laboratory predictors of radiographic progression and their interactions with time was analysed by logistic regression model. Results After 3-years of follow-up, radiographic progression was observed in 54.2% (95%CI: 39.8% to 67.5%) of patients and SDD was 9.5 for total SHS. The percentage of patients with erosive disease increased from 33.3% at baseline to 76% at 36 months. The total SHS of the progressors worsened from a median (interquartile range) of 18.5 (15-20) at baseline to 38.5 (34-42) after 3 years (p < 0.0001) whereas non-progressors worsened from a median of 14.5 (13-20) at baseline to 22.5 (20-30) after 3 years (p < 0.001). In the regression model, time-integrated values of DAS28-CRP and anti-CCP positivity have the highest positive predictive value for progression (both at level of p < 0.0001). Radiographic progression was also predicted by a positive IgM-RF (p0.0009), and a high baseline joint damage (p = 0.0044). Conclusions These data indicate that the level of disease activity, as measured by time-integrated DAS28-CRP, anti-CCP and IgM-RF positivity and a high baseline joint damage, affects subsequent progression of radiographic damage in ERA. PMID:21624120

  2. Short-term monitoring of a gas seep field in the Katakolo bay (Western Greece) using Raman spectra DTS and DAS fibre-optic methods

    NASA Astrophysics Data System (ADS)

    Chalari, A.; Mondanos, M.; Finfer, D.; Christodoulou, D.; Kordella, S.; Papatheodorou, G.; Geraga, M.; Ferentinos, G.

    2012-12-01

    A wide submarine seep of thermogenic gas in the Katakolo bay, Western Greece, was monitored passively using the intelligent Distributed Acoustic Sensor (iDAS) and Ultima Raman spectra Distributed Temperature Sensor (DTS), in order to study the thermal and noise signal of the bubble plumes released from the seafloor. Katakolo is one one of the most prolific thermogenic gas seepage zones in Europe and the biggest methane seep ever reported in Greece. Very detailed repetitive offshore gas surveys, including marine remote sensing (sub-bottom profiling, side scan sonar), underwater exploration by a towed instrumented system (MEDUSA), long-term monitoring benthic station (GMM), compositional and isotopic analyses, and flux measurements of gas, showed that: (a) gas seepage takes place over an extended area in the Katakolo harbour and along two main normal faults off the harbour; (b) at least 823 gas bubble ( 10-20 cm in diameter) plumes escaping over an area of 94,200 m2, at depths ranging from 5.5 to 16 m; (c) the gas consists mainly of methane and has H2S levels of hundreds to thousands ppmv, and shows significant amounts of other light hydrocarbons like ethane, propane, iso-butane and C6 alkanes, (d) offshore and onshore seeps release the same type of thermogenic gas; (e) due to the shallow depth, more than 90 % of CH4 released at the seabed enters the atmosphere, and (f) the gas seeps may produce severe geohazards for people, buildings and construction facilities due to the explosive and toxicological properties of methane and hydrogen sulfide, respectively. For the short-term monitoring, the deployment took place on a site located inside the harbour of Katakolo within a thermogenic gas seepage area where active faults are intersected. The iDAS system makes it possible to observe the acoustical signal along the entire length of an unmodified optical cable without introducing any form of point sensors such as Bragg gratings. When the bubble plumes are released by the seabed into the water column, they ring at their resonance frequency in a manner consistent with standard bubble acoustics. This bubble ringing can be detected by iDAS allowing for both seepage detection, quantification and relationship with seismic activity. The DTS system makes it possible to observe temporal variations of the gas plumes and its relationship with the meteorological factors of the area. Moreover, DTS and iDAS data interpretation needs a detailed examination in comparison with the long-term GMM monitoring data (O2, CH4, H2S, temperature, pressure and conductivity) which was collected from the same location. The processing chain used to observe this phenomenon can have applications in both industrial and environmental monitoring capacities.

  3. Effect of thermal stratification on free convection in a square porous cavity filled with a nanofluid using Tiwari and Das' nanofluid model

    NASA Astrophysics Data System (ADS)

    Sheremet, M. A.; Dinarvand, S.; Pop, I.

    2015-05-01

    Natural convection in a square porous cavity filled with a nanofluid in conditions of thermal stratification has been numerically studied. The mathematical model has been formulated in terms of the dimensionless stream function and temperature using the Darcy-Boussinesq approximation and Tiwari and Das' nanofluid model with new more realistic empirical correlations for the physical properties of the nanofluids. Formulated partial differential equations along with the corresponding boundary conditions have been solved by the finite difference method. Particular efforts have been focused on the effects of the Rayleigh number, thermal stratification parameter, porosity of the porous medium, solid volume fraction parameter of nanoparticles, and the solid matrix of the porous medium (glass balls and aluminum foam) on the local and average Nusselt numbers, streamlines and isotherms. It has been observed an essential effect of thermal stratification parameter on heat and fluid flow fields.

  4. Dating human occupation at Toca do Serrote das Moendas, So Raimundo Nonato, Piau-Brasil by electron spin resonance and optically stimulated luminescence.

    PubMed

    Kinoshita, Angela; Skinner, Anne R; Guidon, Niede; Ignacio, Elaine; Felice, Gisele Daltrini; Buco, Cristiane de A; Tatumi, Sonia; Yee, Mrcio; Figueiredo, Ana Maria Graciano; Baffa, Oswaldo

    2014-12-01

    Excavation of Toca do Serrote das Moendas, in Piau state, Brazil revealed a great quantity of fossil wild fauna associated with human remains. In particular, fossils of a cervid (Blastocerus dichotomus) were found, an animal frequently pictured in ancient rock wall paintings. In a well-defined stratum, two loose teeth of this species were found in close proximity to human bones. The teeth were independently dated by electron spin resonance (ESR) in two laboratories. The ages obtained for the teeth were 29 3 ka (thousands of years) and 24 1 ka. The concretion layer capping this stratum was dated by optically stimulated luminescence (OSL) of the quartz grains to 21 3 ka. As these values were derived independently in three different laboratories, using different methods and equipment, these results are compelling evidence of early habitation in this area. PMID:25456825

  5. Application of a Fibre Optic Distributed Acoustic Sensor (DAS) for Shallow Seismic Investigations of a Fractured Dolostone Aquifer in Guelph, Ontario.

    NASA Astrophysics Data System (ADS)

    Munn, J. D.; Parker, B. L.; Coleman, T. I.; Mondanos, M.; Chalari, A.

    2014-12-01

    Understanding groundwater flow and contaminant transport in fractured bedrock aquifers requires detailed characterization of the discrete features that control flow, as well as the properties of the rock matrix. This requires multiple, high-resolution, depth discrete datasets that provide different, but complementary information. Distributed fibre optic sensing is a relatively new technology used to continuously monitor properties along the entire length of an optical fibre. Technological advances over the past few years have brought the sensitivity and spatial resolution to the point where shallow (<200m) borehole applications are practicable. Recent studies using fibre optic distributed temperature sensors (DTS) have shown excellent application of DTS for characterizing groundwater flow in both continuously sealed and open boreholes. This presentation highlights the results of a field trial at the Bedrock Aquifer Research Station on the University of Guelph campus (Ontario, Canada) where a single fibre optic cable was interrogated by both a DTS (Ultima-DTS) and a Distributed Acoustic Sensor (iDAS). DAS is a relatively recent development that allows an optical fibre to be used as a receiver for seismic imaging. These seismic images are produced by sending an optical pulse down the fibre and analyzing the effects of seismic waves on the propagating light. Numerous vertical seismic profiles were collected and the effects of different fibre optic cable structures and coupling techniques were examined. The seismic profiles will help delineate structural features and lithological contacts away from the borehole wall, and will assist in correlating other geophysical, hydraulic, or geological logs collected in the boreholes across the site. Preliminary results show promise for shallow seismic imaging and continued field trials will allow refinement of the technique.

  6. Simultaneous functions of the installed DAS/DAK formaldehyde-assimilation pathway and the original formaldehyde metabolic pathways enhance the ability of transgenic geranium to purify gaseous formaldehyde polluted environment.

    PubMed

    Zhou, Shengen; Xiao, Sunqin; Xuan, Xiuxia; Sun, Zhen; Li, Kunzhi; Chen, Limei

    2015-04-01

    The overexpression of dihydroxyacetone synthase (DAS) and dihydroxyacetone kinase (DAK) from methylotrophic yeasts in chloroplasts created a photosynthetic formaldehyde (HCHO)-assimilation pathway (DAS/DAK pathway) in transgenic tobacco. Geranium has abilities to absorb and metabolize HCHO. Results of this study showed that the installed DAS/DAK pathway functioning in chloroplasts greatly enhanced the role of the Calvin cycle in transgenic geranium under high concentrations of gaseous HCHO stress. Consequently, the yield of sugars from HCHO-assimilation increased approximately 6-fold in transgenic geranium leaves, and concomitantly, the role of three original HCHO metabolic pathways reduced, leading to a significant decrease in formic acid, citrate and glycine production from HCHO metabolism. Although the role of three metabolic pathways reduced in transgenic plants under high concentrations of gaseous HCHO stress, the installed DAS/DAK pathway could still function together with the original HCHO metabolic pathways. Consequently, the gaseous HCHO-resistance of transgenic plants was significantly improved, and the generation of H2O2 in the transgenic geranium leaves was significantly less than that in the wild type (WT) leaves. Under environmental-polluted gaseous HCHO stress for a long duration, the stomata conductance of transgenic plants remained approximately 2-fold higher than that of the WT, thereby increasing its ability to purify gaseous HCHO polluted environment. PMID:25698666

  7. Using the DAS-ELISA Test to Establish an Effective Distance Between Bait Stations for Control of Linepithema humile (Hymenoptera: Formicidae) in Natural Areas.

    PubMed

    Song, Jinbo; Benson, Eric P; Zungoli, Patricia A; Gerard, Patrick; Scott, Simon W

    2015-08-01

    Linepithema humile (Mayr), the Argentine ant, is an invasive pest that has spread throughout the United States and is a problem in natural and managed habitats in South Carolina. Foraging patterns and the effectiveness of liquid baits for control of this pest have been studied in urban areas. However, similar studies have not been conducted in natural areas such as parks, picnic grounds, or campsites. L. humile populations can be large and widespread, making them a major nuisance pest for visitors to these natural areas. The primary objective of this study was to determine an effective distance between bait stations for control of L. humile in a natural area. A double antibody-sandwich enzyme-linked immunosorbent assay (DAS-ELISA) procedure was used to detect individual ants that consumed rabbit immunoglobin (IgG) protein for marking and tracking. In both lab and field conditions, there was a significant difference in the detection of IgG in ants fed protein marker mixed with sugar water compared with ants only fed sugar water. Additional field studies revealed that an individual ant could retain detectable levels of protein marker for 3 d and that an ant feeding on IgG containing bait could be detected over 15?m from the original bait source. Overall, we found that using liquid ant baits, with a placement of 20?m between stations, was effective in reducing L. humile numbers between April to October, 2012 in a natural park area of Lake Greenwood State Park, SC. PMID:26470341

  8. [Nutritional status of patients with breast cancer attended in the Mastology Service of Belo Horizonte's Hospital das Clnicas in the state of Minas Gerais, Brazil].

    PubMed

    de Oliveira, Dirce Ribeiro; Carvalho, Erika Simone Coelho; Campos, Liliane Cunha; Leal, Jos Adalberto; Sampaio, Estela Viana; Cassali, Geovanni Dantas

    2014-05-01

    The scope of this article is to evaluate the nutritional status, body composition and tumor characteristics of 31 patients with breast cancer attended at the Mastology Service of Hospital das Clnicas of the Federal University of Minas Gerais. Dietary data were obtained from the 24-hour dietary recall in the pre-operative state and analyzed by the DietWin Professional 2008 Nutrition Software. Body composition was assessed by bioelectrical impedance analysis. The tumor characterization data were collected from medical records. The mean age of patients was 50.75 14.34 years. Excess body weight was found in 58% and waist circumference greater than 80 cm in 64.5% of patients Excessive consumption of oils and sugars was observed in 90.3% and 83.8%, respectively. Most had low intakes of calcium and vitamins B6, B12 and A. The predominant diagnosis was type II histological grade invasive ductal carcinoma in stage II or III. The prevalence of overweight and inadequate dietary intake demonstrate the need for individualized nutritional guidance and monitoring to improve the prognosis and quality of the life of patients. PMID:24897222

  9. Migration of inorganic ions from the leachate of the Rio das Ostras landfill: a comparison of three different configurations of protective barriers.

    PubMed

    Lacerda, Cludia Virgnia; Ritter, Elisabeth; Pires, Joo Antnio da Costa; de Castro, Jos Adilson

    2014-11-01

    Batch tests and diffusion tests were performed to analyze the efficiency of a protective barrier in a landfill consisting of compacted soil with 10% bentonite compared to the results obtained for only compacted soil and for compacted soil covered with a 1-mm-thick HDPE geomembrane; the soil and leachate were collected from the Rio das Ostras Landfill in Rio de Janeiro, Brazil. The diffusion tests were performed for periods of 3, 10 and 60 days. After the test period, the soil pore water was analyzed and the profiles for chloride, potassium and ammonium were determined along a 6-cm soil depth. The results of the batch tests performed to define sorption parameters were used to adjust the profiles obtained in the diffusion cell experiment by applying an ion transfer model between the interstitial solution and the soil particles. The MPHMTP model (Multi Phase Heat and Mass Transfer Program), which is based upon the solution of the transport equations of the ionic contaminants, was used to solve the inverse problem of simultaneously determining the effective diffusion coefficients. The results of the experimental tests and of the model simulation confirmed that the compacted soil with 10% bentonite was moderately efficient in the retention of chloride, potassium and ammonium ions compared to the configurations of compacted soil with a geomembrane and compacted soil alone, representing a solution that is technically feasible and requires potentially lower costs for implementation in landfills. PMID:25042116

  10. Test of diurnal and semidiurnal tidal analysis of temperatures from SABER-like sampling of a realistic global model, CMAM-DAS

    NASA Astrophysics Data System (ADS)

    Meek, C. E.; Manson, A. H.; Drummond, J. R.

    2011-05-01

    Because the TIMED satellite orbit precesses slowly in local time, 3 degrees (12 min) per day, thus apparently covering all local times at low and mid latitudes in 2 months when ascending and descending nodes are included, there is a potential for determining migrating and non-migrating tides from temperatures. Many papers have been written on the subject, but none have taken a realistic model atmosphere with high time resolution and tested tidal analysis. The present paper contains results from a tidal analysis of a SABER-sampled global model, the Canadian Middle Atmosphere (data assimilated) Model, CMAM-DAS, which has hourly values, and compares these with analysis using the full model. Fits to 60 d intervals at the equator show reasonable agreement between full and SABER-sampled data analysis for mean, diurnal and semidiurnal tides, with or without inclusion of a linear detrend term. At 50 N where there is irregular coverage of local times, there are serious disagreements in all parameters except the background mean, and detrending has a significant effect.

  11. Das mechatronische Fahrwerk der Zukunft

    NASA Astrophysics Data System (ADS)

    Rieth, Peter

    Technologiesprnge gab es immer wieder in der Geschichte der Automobiltechnologie, so auch in der Kraftfahrzeugbremse, die seit ihren Anfngen eine stete Weiterentwicklung erfahren hat (Bild 40-1). So erlangten schon mechanische Bremsen durchaus ein hohes Niveau, ehe die Hydraulik Mitte der zwanziger Jahre fr Komfort und Sicherheit vollkommen neue Perspektiven erffnete, welche durch Einfhrung der Hilfskraft(servo)bremsanlagen Mitte des letzten Jahrhunderts noch erweitert wurden. Den wichtigsten Technologiesprung, den der Kunde als Fortschritt erkennt und dementsprechend honoriert, ermglichte die Elektronik Mitte der siebziger Jahre. ABS, ASR, EBV und nicht zuletzt ESC wren ohne sie nicht vorstellbar.

  12. Das Echo aus der Tiefe

    NASA Astrophysics Data System (ADS)

    Beck, Paul G.; Kallinger, Thomas

    2013-04-01

    Seit nunmehr vier Jahren liefert der NASA-Satellit Kepler Helligkeitsmessungen von mehr als 170 000 Sternen mit nie zuvor erreichter Genauigkeit. Obwohl er für die Suche nach extrasolaren Planeten konzipiert ist, sind diese Daten eine wahre Fundgrube für die Asteroseismologie. Einen aktuellen Durchbruch im Verständnis entwickelter Sterne, den Roten Riesen, stellt die Entdeckung von "Mixed Modes" dar, welche die Erforschung des tiefen Sterninneren ermöglichen.

  13. Membrane-associated DNase activity controlled by genes 46 and 47 of bacteriophage T4D and elevated DNase activity associated with the T4 DAS mutation

    SciTech Connect

    Mickelson, C.; Wiberg, J.S.

    1981-10-01

    Lethal, amber mutations in T4 genes 46 and 47 cause incomplete degradation of host DNA, premature arrest of phage DNA synthesis, accumulation of abnormal DNA replication intermediates, and defective recombination. These phenotypes can be explained by the hypothesis that genes 46 and 47 control a DNA exonuclease, but in vitro demonstration of such a nuclease has not yet been reported. Membrane and supernatant fractions from 46/sup -/ and 47/sup -/ mutant-infected and 46/sup +/ 47/sup +/ control-infected cells were assayed for the presence of the protein products of these genes (i.e., gp46 and gp47) and for the ability to degrade various DNA substrates to acid-soluble products in vitro. The two proteins were found only on membranes. The membrane fraction from 46/sup -/ 47/sup -/ mutant-infected cells digested native or heavily nicked Escherichia coli DNA to acid-soluble products three to four times slower than the membrane fraction from control-infected cells. No such effect was found in the cytoplasmic fractions. The effect on nuclease activity in membranes was the same whether 47/sup -/ and 47/sup -/ mutants were present singly or together. NaClO/sub 4/, a chaotropic agent, released both gp46 and gp47 from 46/sup +/ 47/sup +/ membranes, as well as the DNase activity controlled by genes 46 and 47. DNA cellulose chromatography of proteins released from membranes by NaClO/sub 4/ showed that gp46 and gp47 bound to the native DNAs of both E. coli and T4. Thus, the overall enrichment of gp46 and gp47 relative to total T4 protein was 600-fold (10-fold in membranes, 2-fold more upon release from membranes by NaClO/sub 4/, and 30-fold more upon elution from DNA cellulose). T4 das mutations, which partially suppress the defective phenotype of 46/sup -/ and 47/sup -/ mutants, caused a considerable increase in in vitro DNase activity in both membrane and cytoplasmic fractions.

  14. Entwicklung von umwelt- und naturschutzgerechten Verfahren der landwirtschaftlichen Landnutzung für das Biosphärenreservat Schorfheide-Chorin

    NASA Astrophysics Data System (ADS)

    Meyer-Aurich, Andreas

    1999-11-01

    Mit der vorliegenden Arbeit werden exemplarisch Chancen und Grenzen der Integration von Umwelt- und Naturschutz in Verfahren der ackerbaulichen Landnutzung aufgezeigt. Die Umsetzung von Zielen des Umwelt- und Naturschutzes in Verfahren der Landnutzung ist mit verschiedenen Schwierigkeiten verbunden. Diese liegen zum einen in der Konkretisierung der Ziele, um diese umsetzen zu können, zum anderen in vielfach unzulänglichem Wissen über den Zusammenhang zwischen unterschiedlichen Formen der Landnutzung und insbesondere den biotischen Naturschutzzielen. Zunächst wird die Problematik der Zielfestlegung und Konkretisierung erörtert. Das Umweltqualitätszielkonzept von Fürst et al. (1992) stellt einen Versuch dar, Ziele des Umwelt- und Naturschutzes zu konkretisieren. Dieses Konzept haben Heidt et al. (1997) auf einen Landschaftsausschnitt von ca. 6000 ha im Biosphärenreservat Schorfheide-Chorin im Nordosten Brandenburgs angewendet. Eine Auswahl der von Heidt et al. (1997) formulierten Umweltqualitätsziele bildet die Basis dieser Arbeit. Für die ausgewählten Umweltqualitätsziele wurden wesentliche Einflussfaktoren der Landnutzung identifiziert und ein Bewertungssystem entwickelt, mit dem die Auswirkungen von landwirtschaftlichen Anbauverfahren auf diese Umweltqualitätsziele abgebildet werden können. Die praktizierte Landnutzung von 20 Betrieben im Biosphärenreservat Schorfheide-Chorin wurde von 1994 bis 1997 hinsichtlich ihrer Auswirkungen auf die Umweltqualitätsziele analysiert. Die Analyse ergab ein sehr differenziertes Bild, das zum Teil Unterschiede in der Auswirkung auf die Umweltqualitätsziele für den Anbau einzelner Kulturen oder für bestimmte Betriebstypen zeigte. Es zeigte sich aber auch, dass es bei der Gestaltung des Anbaus einzelner Kulturarten große Unterschiede gab, die für Umweltqualitätsziele Bedeutung haben. Neben der Analyse der Landnutzung im Biosphärenreservat Schorfheide-Chorin wurde ein System entwickelt, mit dem die modellhafte Abbildung von Verfahren der Landnutzung möglich ist. Die Modellverfahren wurden in eine umfangreiche Datenbank eingebunden. Sie wurden mit Hilfe eines Fuzzy- Regelsystems hinsichtlich ihrer Auswirkungen auf die Umweltqualitätsziele bewertet. Die systematisch bewerteten Verfahren wurden in ein Betriebsmodell integriert, womit eine weitergehende Analyse der Zielbeziehungen und die Berechnung von Szenarien mit unterschiedlichen Rahmenbedingungen ermöglicht wurde. Die Analyse der Beziehung verschiedener Ziele zueinander (Zieldivergenz, Zielkonvergenz) zeigte, dass sich mit der Verfolgung vieler Umweltqualitätsziele auch positive Effekte für andere Umweltqualitätsziele ergaben. Teilweise konnte allerdings auch eine Zieldivergenz festgestellt werden, die auf mögliche Zielkonflikte hinweist. Bei der Analyse der Szenarienergebnisse zeigte sich, dass die vorgeschlagenen Veränderungen von Rahmenbedingungen vielfach eine Verschlechterung für verschiedene Umweltqualitätsziele mit sich bringen. Eine Ursache dafür liegt darin, dass bei der Definition der Szenarien die Bedeutung der Stilllegungen unterschätzt wurde. The objective of this research was to show the opportunities and limitations associated with integrating of environmental goals into agricultural land use management. For this purpose, the impact of agricultural land uses on six environmental quality goals was analysed for an approximately 16.000 ha study region within the biosphere reserve Schorfheide-Chorin in north-eastern Brandenburg (Germany). The environmental quality goals considered were protection of ground water, preservation of groundwater recharge, protection of the soil against wind and water erosion and preservation of animal species typical of the agricultural landscape, in particular partridge, amphibians and cranes. For each environmental quality goal, an evaluation framework is presented which enables an assessment of the impact of agricultural land uses on the environmental quality goals. The evaluation framework was applied to assess the impact of land uses of twenty farms in the study area from 1994 to 1997. It was demonstrated that the impact of agricultural land uses on the environmental quality of the region is very complex, and - although some crops did significantly impact certain aspects, one factor did not overwhelmingly contribute to the overall environmental quality. The evaluation framework was integrated further into a system of modelled cropping practices for optimisation calculations. For this purpose, a model framework was established based on a MS Access database. In the database, cropping practices for 17 crops are stored. Inputs and yields are adapted to the site-specific yield potential. In addition to the cropping practices, the model framework is comprised of an evaluation module and optimisation module. Hence, the impact of the cropping practices can be assessed for each site. This model framework provides the basis for optimisation calculations to forecast various land uses under different conditions. A step-wise integration of the environmental quality goals into the optimisation algorithm of a model farm allows for showing trade-offs between economic and ecological goals. The results of the trade-offs show that an improvement of ecological goal achievement is possible with little impact on the gross margin, as long as the improvement is less than 30% of the starting situation. If improvements greater than 30% are desired, very high losses of gross margin must be taken into consideration. Another result of the calculations shows that high achievements of environmental quality goals often correlate with the percentage of set-aside land within the total area.

  15. Screening for pulmonary tuberculosis in Terespolis, RJ, Brazil: the search for respiratory symptomatic patients in emergency service of "Hospital das Clnicas de Terespolis Costantino Ottaviano, Fundao Educacional Serra dos Orgos".

    PubMed

    Siqueira-Batista, Rodrigo; Gomes, Andria Patrcia; Bisaglia, Joana B; Borlot, Paulo Estevo W; D'avila Junior, Heraldo X; Faria, Carolina Gonalves P P de; Braga, Bernardo D; Bezerra, Tiago S; Cedrola, Juan Pedro V; Almeida, Guilherme C; Couto, Llian S; Nacif, Marcelo; Crivano, Elvira

    2005-01-01

    The aim of the present study was to investigate the detection percentage of tuberculosis among patients that are respiratory symptomatic (TB suspects). In this work, we present the preliminary results of research carried out at "Hospital das Clnicas de Terespolis Costantino Ottaviano da Fundacao Educacional Serra dos Orgos (FESO)" from November 2003 to April 2004. Among the 40 respiratory symptomatic individuals identified and referred to the Tuberculosis Control Program in Terespolis , two (5.0%) were characterized as smear-positive. These results confirm reports in the literature and underscore the need for and importance of this strategy. PMID:15880227

  16. Vernetztes Lernen: Eine Unterrichtseinheit mit Heinrich von Kleists Erzahlung "Das Erdbeben in Chili" und Crista Wolfs Roman "Kein Ort. Nirgends" (Networked Learning: An Instructional Unit with Heinrich von Kleist's Story "The Earthquake in Chile" and Christa Wolf's Novel "No Place, No Where").

    ERIC Educational Resources Information Center

    Eidecker, Martina Elisabeth

    1999-01-01

    Presents an instructional model, using Kleist's story "Das Erdbeben in Chili" and Christa Wolf's novel Kei Ort. Nirgends" as a basis. The model clearly distinguishes itself from quantitative models and mediates solid literary knowledge through an inductive approach. Learning takes place in a multidimensional space that makes possible multiple

  17. Mapping health assessment questionnaire disability index (HAQ-DI) score, pain visual analog scale (VAS), and disease activity score in 28 joints (DAS28) onto the EuroQol-5D (EQ-5D) utility score with the KORean Observational study Network for Arthritis (KORONA) registry data.

    PubMed

    Kim, Hye-Lin; Kim, Dam; Jang, Eun Jin; Lee, Min-Young; Song, Hyun Jin; Park, Sun-Young; Cho, Soo-Kyung; Sung, Yoon-Kyoung; Choi, Chan-Bum; Won, Soyoung; Bang, So-Young; Cha, Hoon-Suk; Choe, Jung-Yoon; Chung, Won Tae; Hong, Seung-Jae; Jun, Jae-Bum; Kim, Jinseok; Kim, Seong-Kyu; Kim, Tae-Hwan; Kim, Tae-Jong; Koh, Eunmi; Lee, Hwajeong; Lee, Hye-Soon; Lee, Jisoo; Lee, Shin-Seok; Lee, Sung Won; Park, Sung-Hoon; Shim, Seung-Cheol; Yoo, Dae-Hyun; Yoon, Bo Young; Bae, Sang-Cheol; Lee, Eui-Kyung

    2016-04-01

    The aim of this study was to estimate the mapping model for EuroQol-5D (EQ-5D) utility values using the health assessment questionnaire disability index (HAQ-DI), pain visual analog scale (VAS), and disease activity score in 28 joints (DAS28) in a large, nationwide cohort of rheumatoid arthritis (RA) patients in Korea. The KORean Observational study Network for Arthritis (KORONA) registry data on 3557 patients with RA were used. Data were randomly divided into a modeling set (80 % of the data) and a validation set (20 % of the data). The ordinary least squares (OLS), Tobit, and two-part model methods were employed to construct a model to map to the EQ-5D index. Using a combination of HAQ-DI, pain VAS, and DAS28, four model versions were examined. To evaluate the predictive accuracy of the models, the root-mean-square error (RMSE) and mean absolute error (MAE) were calculated using the validation dataset. A model that included HAQ-DI, pain VAS, and DAS28 produced the highest adjusted R (2) as well as the lowest Akaike information criterion, RMSE, and MAE, regardless of the statistical methods used in modeling set. The mapping equation of the OLS method is given as EQ-5D = 0.95-0.21 × HAQ-DI-0.24 × pain VAS/100-0.01 × DAS28 (adjusted R (2) = 57.6 %, RMSE = 0.1654 and MAE = 0.1222). Also in the validation set, the RMSE and MAE were shown to be the smallest. The model with HAQ-DI, pain VAS, and DAS28 showed the best performance, and this mapping model enabled the estimation of an EQ-5D value for RA patients in whom utility values have not been measured. PMID:26849891

  18. Kanban - der Weg ist das Ziel

    NASA Astrophysics Data System (ADS)

    Aull, Florian; Berlak, Joachim; Dickmann, Eva; Dickmann, Philipp; Fischäder, Holm; Gerlach, Joachim; Henneberg, Jens; Kapalla, Klaus; Kress, Oliver; Kuttler, Robert; Schneider, Herfried M.; Schürle, Philipp; Stellpflug, Franz-Josef; Wannenwetsch, Ralph; Wulz, Johannes; Zäh, Michael F.

    Wenn man aktuell Produktionsbereiche in Deutschland und Europa besucht, fallen im Zusammenhang mit modernen Produktionsmethoden immer öfter die Begriffe Kanban (jap. Karte, Signal) und Pull-Produktion, und dies nicht ohne Stolz, da diese mit dem schillernden Vorbild des Toyota Produktionssystems in Zusammenhang stehen. Tatsächlich ist Kanban ein integraler Bestandteil moderner Produktionssysteme. Blickt man aber im Rahmen von Prozessanalysen hinter die Fassaden", d. h. in die tägliche Praxis der Arbeitsprozesse, wird man schnell desillusioniert - die viel gepriesenen klassischen Kanban-Regeln werden im Tagesgeschäft nicht eingehalten.

  19. Internationale Schulreformtendenzen und das Problem der Lehrerausbildung

    NASA Astrophysics Data System (ADS)

    Kupisiewicz, Czeslaw

    1982-09-01

    The main theme of this article is that the socio-economic and educational changes which have occurred in industrialized countries in the past 20 to 25 years necessitate a thorough reform of the present system of teacher education. The first group of such changes includes the information explosion, greater occupational mobility, the growing significance and increasing role of the sciences, the development of the mass media, higher educational aspirations, technical development, the acceleration of the psycho-physical development of children and youth, and the injurious effects of the uncontrolled development of the constantly changing civilisation (deterioration of the human environment, diseases caused by the effects of civilisation, etc.). In the face of these changes, teachers must not remain indifferent and teacher education systems have to take them into account. Within the second group of changes influencing the content and methods of teacher education, the most important is the generalisation of education at the pre-school, primary and secondary school levels and also at the university level. As a result, education in many types of school and at ever higher levels has lost the elitist character it still had, not so long ago, and has become a mass activity. This has considerably affected teachers' work and, necessarily, also the work of the teacher education systems. In present-day schools it is necessary to emphasize not only the transmission of knowledge of the `know that' type, as was done in the past, but also problem-solving, independent individual and group work, etc., which will enable children and young people to acquire `know-how' and `know-why'. This must also be reflected in teacher education. In order to adapt the teacher education systems to the requirements of the changing society, a reform of the goals, contents and methods of the system will have to be prepared and implemented as a prerequisite and starting point for a global reform of the entire education system.

  20. Ozeanische Tiefenzirkulation: Meeresstrmungen beeinflussen das Klima

    NASA Astrophysics Data System (ADS)

    Rhein, Monika

    Meeresstrmungen transportieren groe Mengen an Wrme ber den Globus und heizen oder khlen ihre Umgebung. Wie der Treibhauseffekt auf den Ozean und die Rckkopplung diese nderungen aufs Klima wirkt, lsst sich bislang nicht vorhersagen. Ein entscheidender Faktor hierbei ist die Bildung von Tiefenwasser. Daher wird zunehmend versucht, mit experimentellen Mitteln die Bildung von Tiefenwasser und damit die Umwlzbewegungen in den Ozeanen zu messen. Als Tracer eignen sich hierfr die FCKW.

  1. Das Gluck des Lehrers (The Teacher's Happiness).

    ERIC Educational Resources Information Center

    Higgins, Christopher

    2002-01-01

    Argues that the ethics of teaching concerns the relationship between the teaching and the good life. Uses Bernard Williams' ethics/morality distinction. Connects the question of "why teach?" with the question "how should I live?" Asks why the practice of teaching is worth it in terms of self growth and monetary gains. (CAJ)

  2. Physikgeschichte Das Rätsel bleibt

    NASA Astrophysics Data System (ADS)

    Hoffmann, Dieter

    2002-05-01

    Die jüngst erfolgte Veröffentlichung von Dokumenten aus dem Privatarchiv der Familie Bohr [1] über den geheimnisumwitterten Besuch von Werner Heisenberg in Kopenhagen im September 1941 hat in den deutschen Medien große Resonanz gefunden [2]. Tatsächlich verraten uns die jetzt veröffentlichten Dokumente sehr viel mehr über die Zeit ihres Entstehens als über den Besuch selbst.

  3. Determinação da massa de júpiter a partir das órbitas de seus satélites: um experimento didático

    NASA Astrophysics Data System (ADS)

    Schlickmann, M. S.; Saito, R. K.; Becker, D. A.; Rezende, M. F., Jr.; Cid Fernandes, R.

    2003-08-01

    Este trabalho apresenta o roteiro piloto de uma prática observacional em astronomia, junto com os primeiros resultados obtidos nesta fase de implementacão. O projeto, que será executado em duas etapas, visa introduzir noções de Astronomia a alunos do Ensino Médio e iniciantes nos cursos de Física. O experimento consiste em medir as órbitas dos satélites Galileanos e, a partir da análise dos dados coletados, verificar a validade da Lei das órbitas de Kepler, determinando a massa do planeta Júpiter. Em uma primeira etapa, as observações serão feitas utilizando um telescópio Meade LX200 10" e câmera CCD para obter uma seqüência de imagens do planeta, que possibilitará medir o movimento de seus satélites. A segunda etapa terá início a partir do funcionamento do telescópio em modo robótico, com a possibilidade de observações via internet por instituições de ensino. Para o desenvolvimento deste experimento foram inicialmente coletadas várias imagens de Júpiter obtidas com os instrumentos citados acima. Estas imagens serviram como base para confecção dos roteiros para a experiência no nível médio e superior. Os roteiros serão inicialmente apresentados em uma home-page. Nela também se buscará uma contextualização histórica da experiência bem como o estabelecimento de relações com professores e alunos, propostas metodológicas e a disponibilização dos programas computacionais necessários para a utilização "on-line" pelos usuários. O projeto conta com apoio da Fundação VITAE.

  4. Importance of land use update during the calibration period and simulation of water balance response to land use change in the upper Rio das Mortes Catchment (Cerrado Biome, Central-Western Brazil)

    NASA Astrophysics Data System (ADS)

    Lamparter, Gabriele; Kovacs, Kristof; Nobrega, Rodolfo; Gerold, Gerhard

    2015-04-01

    Changes in the hydrological balance and following degradation of the water ecosystem services due to large scale land use changes are reported from agricultural frontiers all over the world. Traditionally, hydrological models including vegetation and land use as a part of the hydrological cycle use a fixed distribution of land use for the calibration period. We believe that a meaningful calibration - especially when investigating the effects of land use change on hydrology - demands the inclusion of land use change during the calibration period into the calibration procedure. The SWAT (Soil and Water Assessment Tool) model is a process-based, semi-distributed model calculating the different components of the water balance. The model bases on the definition of hydrological response units (HRUs) which are based on soil, vegetation and slope distribution. It specifically emphasises the role of land use and land management on the water balance. The Central-Western region of Brazil is one of the leading agricultural frontiers, which experienced rapid and radical deforestation and agricultural intensification in the last 40 years (from natural Cerrado savannah to cattle grazing to intensive corn and soya cropland). The land use history of the upper Rio das Mortes catchment (with 17500 km²) is reasonably well documented since the 1970th. At the same time there are almost continuous climate and runoff data available for the period between 1988 and 2011. Therefore, the work presented here shows the model calibration and validation of the SWAT model with the land use update function for three different periods (1988 to 1998, 1998 to 2007 and 2007 to 2011) in comparison with the same calibration periods using a steady state land use distribution. The use of the land use update function allows a clearer identification which changes in the discharge are due to climatic variability and which are due to changes in the vegetation cover. With land use update included into the calibration procedure, the impact of land use change on overall modelled runoff was more pronounced. For example, the accordance of modelled peak discharge improved for the period from 1988 to 1998 (with a decrease of primary Cerrado from 60 to 30 %) with the use of the land use update function compared to the steady state calibration. The effect for the following two periods 1998 to 2007 and 2007 to 2011 (with a decrease of primary Cerrado from 30 to 24 % and 24 to 19 % respectively) show only a small improvement of the model fit.

  5. 77 FR 65405 - National Register of Historic Places; Notification of Pending Nominations and Related Actions

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-26

    ..., Portland, 12000933 PUERTO RICO Aguas Buenas Municipality Parque de Bombas Maximiliano Merced, (Fire Stations in Puerto Rico MPS) 42 Munoz Rivera St., Aguas Buenas, 12000934 Florida Municipality De...

  6. Proving the Orbits of the Galilean Moons Through Astrophotography. (Spanish Title: Comprobando Las Órbitas de Las Lunas Galileanas a Través de la Astrofotografía.) Evidenciando as Órbitas das Luas Galileanas Atravéd da Astrofotografia

    NASA Astrophysics Data System (ADS)

    Iachel, Gustavo

    2009-12-01

    An activity related to the observation of the Galilean moons and to amateur astrophotography is presented in this work. Through the reading of excerpts of the book Sidereus Nuncius (Sidereal Messenger), by Galileo, it is possible to trace a methodology to observe the planet and its natural satellites and, with the aid of the astrophotography, to analyze the field recordings. Moreover, it is possible to compare the images obtained after plotting the relative positions of these moons to prove their orbits. This activity can be conducted by teachers, students and amateur astronomers, in order to develop their capabilities of observation of astronomical phenomena. Se presenta en este trabajo una actividad relacionada a la observación de las lunas Galileanas y a la astrofotografía amateur. A través de la lectura de tramos de la obra Sidereus Nuncius (El Mensajero Sideral) de Galileo, es posible trazar una metodología para la observación del planeta y de sus satélites naturales y, con el auxilio de la astrofotografía, analizar las anotaciones de campo. Además, es posible comparar las imágenes obtenidas con el gráfico de las posiciones relativas de estas lunas para comprobar sus órbitas. Esa actividad puede ser realizada por maestros, estudiantes y astrónomos amateurs, de forma a desarrollar sus capacidades de observación de los fenómenos astronómicos. Uma atividade relacionada à observação das luas Galileanas e à astrofotografia amadora é apresentada neste trabalho. Através da leitura de trechos da obra Sidereus Nuncius (Mensageiro Sideral), de Galileu, é possível traçar uma metodologia para a observação do planeta e de seus satélites naturais e, com o auxílio da astrofotografia, analisar as anotações de campo. Além disso, é possível comparar as imagens obtidas com o gráfico das posições relativas destas luas para evidenciar suas órbitas. Essa atividade pode ser realizada por professores, estudantes e astrônomos amadores, de forma a desenvolverem suas capacidades de observar fenômenos astronômicos.

  7. Das Isotopenthermometer im ewigen Eis: Mechanismen globaler Klimaschwankungen

    NASA Astrophysics Data System (ADS)

    Stauffer, Bernhard

    Die Analysen von zwei Bohrkernen im grnlndischen Eis haben unser Wissen ber Klimaschwankungen und deren mgliche Ursachen stark erweitert. Die 18 O-Messreihe zeigt, dass der bergang von der letzten Eiszeit zur Nacheiszeit in drastischen Sprngen erfolgte und dass es auch whrend der Eiszeit schnelle, drastische Klimanderungen, so genannte Dansgaard-Oeschger -Ereignisse gab. Basierend auf der heute gltigen Beziehung zwischen mittlerer Jahrestemperatur und 18 O-Wert nahm man an, dass der Temperaturanstieg zwischen Eiszeitmaximum und Nacheiszeit rund 12C und zu Beginn eines Dansgaard-Oeschge-Ereignisses rund 8C betrugen. Neue Kalibrationsmethoden haben gezeigt, dass die Temperatursprnge praktisch doppelt so gro waren, wie die mit der Dansgaard-Beziehung ermittelten. Erstaunlich sind vor allem die schnellen Temperaturanstiege. Ein Temperaturanstieg von mehr als 10C e folgte oft in wenigen Jahrzehnten. Die Methanmessreihe ergab, dass die Dansgaard-Oeschger -Ereignisse kein auf Grnland beschrnktes Phnomen sind. Es sind Klimaschwankungen von globaler Bedeutung. Die zeitliche Synchronisation von Messreihen auf Grnland und der Antarktis mithilfe von Methanvariationen ergab, dass einer abrupten Erwrmung in Grnland oft eine Erwrmung in der Antarktis vorausging. Von zwei Kernbohrungen im Rahmen des European Project for Ice Coring in Antarctica erwartet man vor allem neue Erkenntnisse ber Klimawechselwirkungen zwischen den beiden Hemisphren und ber die Ursachen der Variationen von Treibhausgaskonzentrationen parallel zu globalen Klimaschwankungen.

  8. Entkolonialisierung der Erziehung das Beispiel Der VR Kongo

    NASA Astrophysics Data System (ADS)

    Radtke, Frank-Olaf; Gstettner, Peter; Streiffeler, Friedhelm

    1981-03-01

    The first part of this contribution attempts to recapitulate the economic and social conditions facing educational policy in post-colonial Africa. The second part shows that the dependence on world economy is aggravated by the separation of education from productive work, which is a concomitant of the institutionalisation of education. In the communally-organised traditional African societies, education was incumbent on all members of the society; it was part of the common life-and-work process. It was not until the school as institution had been introduced that education came to be governed by the principles of the division of labour and took over the function of the selection and creation of privilege. This has led to an alientation of school leavers from productive work. The educational system as a whole can no longer support those societal tasks that require creativity and development. Following a phase of quantitative expansion, the third part points out that African educational policy is currently making great efforts to give the educational system a qualitative reorientation towards the real needs of African societies. The fourth part describes the detachment from Euro-American strategies of development and innovation, and the revaluation of elements of traditional education. Taking as an example the programme, `Ecole du peuple', which aims to reorganise the educational system of the People's Republic of the Congo from pre-school to university, the difficulties of such an undertaking are investigated.

  9. ber das monotone Verhalten gewisser Zustandssummen bei Temperaturausgleich

    NASA Astrophysics Data System (ADS)

    Zylka, Christian

    Wir lenken die Aufmerksamkeit darauf, da die kanonische Zustandsumme Z(1, 2, , n) Z(?) eines aus n unabhngigen Teilsystemen zusammengesetzten thermodynamischen Systems eine schurkonvexe Funktion ist. Dabei bezeichnet ?i die inverse Temperatur des i-ten Teilsystems. Falls die innere Energie proportional zu ? ist - wie etwa bei Spinsystemen in Hochtemperatur-Nherung - so folgt aus der Schurkonvexitt, da beliebiger Temperaturausgleich zwischen den Teilsystemen stets zu einem Abfallen von Z(?) fhrt.Translated AbstractOn the Monotonic Behaviour of Certain Partition Functions under Temperature EqualizationWe stress that the canonical partition function Z(?1, ?2, , ?n) Z(?) of a thermodynamical system consisting of n independent subsystems is a Schur-convex function. By ?i the inverse temperature of the i-th subsystem is denoted. If the internal energy is proportional to ? - as e.g. for spin systems in the high temperature approximation - then from the Schur-convexity it follows that arbitrary temperature equalization between the subsystems can only diminish Z(?).

  10. Das Deutschlandspiegelvideo (The View-of-Germany-Videos).

    ERIC Educational Resources Information Center

    Pentecost, Gislind E.

    1993-01-01

    Describes View-of-Germany-Videos, published by the Goethe Institute. The videos are authentic, entertaining, and very versatile in usefulness. In addition they are short, thus easily incorporated into a lesson plan, and free of charge, making them accessible to any educational establishment. (AB)

  11. Das Schwimmen der Talitridae (Crustacea, Amphipoda): Funktionsmorphologie, Phnomenologie und Energetik

    NASA Astrophysics Data System (ADS)

    Vogel, Friedhelm

    1985-09-01

    The Talitridae, well-known for their jumping behaviour, swim with help of the tail-flip. This movement of the abdomen is also known from other amphipods like the Gammaridae which are normally not able to move by jerks outside the water. The suspected homology between the tail-flip when swimming and the jerky movement of the abdomen when jumping gave rise to this investigation, mainly based on high frequency film recordings, on the swimming of Hyale nilssonii, Orchestia cavimana, and Talitrus saltator (family Talitridae) as well as three related species of the families Gammaridae and Corophiidae. Comparative morphometrical and SEM-studies on the habitus of the species and the build of the involved limbs reveal the rather uniform construction of the Gammaridea; functional adaptation to the environment and to the way of living become apparent in minor alterations. The joints of the pleopods and uropods show a clear structural adaptation to the mechanical strain during swimming. The pleopods are moved metachronally in all examined species; angular velocity and rate of beating indicate the efficiency of the swimming movement. In the Talitridae, the metachronal beat of the pleopods is nearly always coupled with the tail-flip while in the Gammaridae and Corophiidae the tail-flip, in addition to the beat of the pleopods, is mostly used for a start from the subsoil or for a change in swimming direction. H. nilssonii, Gammarus locusta, and Corophium volutator, all inhabitants of the tidal zone in the North Sea shallows, turned out to be the best swimmers while the (semi-) terrestrially living species, O. cavimana and T. saltator, proved to be rather poor swimmers. This clearly indicates the ecological significance of swimming for the different species. Furthermore, the tailflip is found to be of rather subordinate importance. It contributes to a higher velocity if used moderately but is rather obstructive if a large angle is covered while extending and flexing the abdomen. The efficiency of swimming is inversely proportional to the efficiency of jumping in the three talitridean species. Thus, better adaptation to terrestrial life is accompanied by loss of swimming efficiency. Examined under the aspect of locomotional homology, it is concluded that the tail-flip used while swimming is homologous to the jerky movement of the abdomen used for jumping. The comparison of the swimming performance of the examined species with other crustaceans and some fishes illustrates the over-all good results of the Gammaridea.

  12. Dynamisierung und Erstarrung in der modernen Gesellschaft - Das Beschleunigungsphnomen

    NASA Astrophysics Data System (ADS)

    Rosa, Hartmut

    Dass die Geschichte der Moderne die Geschichte einer ungeheuren Beschleunigung "des Lebens, "der Kultur, "der Geschichte oder gar "der Zeit selbst sei, ist eine Behauptung, der man in Bchern ber die Moderne - gelehrten wie ungelehrten - so hufig begegnet, dass sie geradezu als eine Binsenweisheit gelten kann. Vllig unklar bleibt dabei jedoch in aller Regel, was sich dabei wirklich beschleunigt hat und welcher Begriff von Beschleunigung dieser Auffassung zugrunde liegt. Ich will im Folgenden zunchst einen wissenschaftlich vertretbaren Begriff von Beschleunigung entwickeln, um danach mit Hilfe dieses Instruments zu berprfen, inwieweit die Geschichte der Moderne wirklich als eine Beschleunigungsgeschichte aufgefasst werden kann.

  13. Erfolgsfaktoren von Lehrstellenmarketing in der dualen berufsbildung: das beispiel Schweiz

    NASA Astrophysics Data System (ADS)

    Sager, Fritz

    2006-09-01

    SUCCESS FACTORS OF APPRENTICESHIP MARKETING IN A SYSTEM OF DUAL VOCATIONAL TRAINING: THE CASE OF SWITZERLAND - The dual system of vocational training, utilizing both company training and vocational school, is generally acknowledged to be a successful model, but a decreasing number of trainee posts in Switzerland poses a crisis for the approach. One strategy for overcoming the problem involves offering incentives for companies to create new trainee posts. The present study explores the necessary conditions for successfully influencing the number of trainee posts through apprenticeship marketing. A comparision of qualitative case studies of six marketing projects demonstrates that while context, in the sense of basic structural conditions and political sensibility for the problematic, plays a role in the success of a project, what is central is above all the form of the trainee-post marketing project itself. This has to do with the behaviour of the actors involved as well as the choice of the mode of governance and project organization. The latter has to do with making available requisite technical and personal resources, coordination on the part of the project direction, and giving those responsible the necessary room to act in implementing the project.

  14. Das modale Hilfsverb "will" (The Modal Auxiliary Verb "Will")

    ERIC Educational Resources Information Center

    Kunsmann, Peter W.

    1975-01-01

    That "will" and "shall" are modal, not temporal, verbs is shown by their syntactic similarity to the modals and by the fact that they follow the same transformational rules as the modals. This example demonstrates the usefulness of transformational grammar in explaining grammatical relationships to students. (Text is in German.) (IFS/WGA)

  15. Das Sprachlabor in der Schule (The Language Laboratory in Schools).

    ERIC Educational Resources Information Center

    Cabus, Hans-Joachim; Freudenstein, Reinhold

    This technical manual for the use of language laboratories includes information on the following topics: (1) types of laboratories, (2) the tape, (3) the tape recorder, (4) other basic technical equipment, (5) the audio-active laboratory, the audio-active-compare laboratory, and an evaluation of the two, (6) possibilities for expanded use, (7)…

  16. Excising das All: Evolving Maxwell waves beyond Scri

    NASA Technical Reports Server (NTRS)

    vanMeter, James R.; Fiske, David R.; Misner, Charles W.

    2006-01-01

    We study the numerical propagation of waves through future null infinity in a conformally compactified spacetime. We introduce an artificial cosmological constant, which allows us some control over the causal structure near null infinity. We exploit this freedom to ensure that all light cones are tilted outward in a region near null infinity, which allows us to impose excision-style boundary conditions in our finite difference code. In this preliminary study we consider electromagnetic waves propagating in a static, conformally compactified spacetime.

  17. Demokratie lernen am gymnasium: das projekt "schule als staat"

    NASA Astrophysics Data System (ADS)

    Sajak, Clau Peter

    2002-09-01

    (Learning Democracy in High School: the "School as State" Project) - The disquieting social developments in the German Federal Republic are leading to intense discussions about the possibilities of instilling values and democratic attitudes within the context of secondary education. The interdisciplinary educational project "School as State" has been running for some time in various schools in Baden-Wrttemberg. This article describes the goals and processes of this project and examines the didactic approaches from which it emerged.

  18. Astronomy in High School: Using a Mini-Planetarium to Understand Details of the Apparent Movement of Stars. (Spanish Title: Astronomía en la Escuela Secundaria: Comprendiendo los Detalles del Movimiento Aparente de Las Estrellas con un Miniplanetario.) Astronomia no Ensino Médio: Compreendendo Detalhes do Movimento Aparente das Estrelas com um Miniplanetário

    NASA Astrophysics Data System (ADS)

    dos Santos Leão, Demetrius

    2013-07-01

    The aim of this article is to present part of the results obtained by the intervention made from the author's Master degree project, which consisted in the development of a set of Astronomy classes for first year of High School students from a private school in the "Distrito Federal", Brasilia, Brazil, making use of a didactical material called mini-planetarium (MP) as the main resource. Using Paulo Freire's contextualization and dialogicity ideas as a theoretical framework guided by these lessons, it was proposed to the students the assembly and application of that resource in a planetarium session. During the project, some subjects such as the apparent trajectory of stars through Brasilia's sky, the location of the cardinal points beginning from the Southern Cross constellation, the color of stars and the stars being seen from a particular place were emphasized. It was found that the students showed an improvement of their understanding about these subjects, as well as a significant excitement with the developed methodology. El objetivo de este trabajo es presentar algunos de los resultados obtenidos en el proyecto de la tesis de maestría del autor, que incluyó el desarrollo de algunas clases de Astronomía, con estudiantes del primer año del bachillerato de una escuela privada del Distrito Federal (Brasilia, Brasil), utilizando como materia prima didáctica el recurso llamado miniplanetario (MP). Utilizando como base teórica orientadora de esas clases las ideas de contextualización y dialógica de Paulo Freire, fue propuesto a los estudiantes el montaje y la utilización de este recurso en una función de planetario. Durante el proyecto, se enfatizaron asuntos tales como la trayectoria aparente de las estrellas del cielo de Brasilia, la ubicación de los puntos cardinales a partir de la constelación de la Cruz del Sur, los colores de las estrellas y las estrellas vistas desde una localidad determinada. Se constató que los estudiantes mostraron una mejora en la comprensión de estas cuestiones y demostraron un gran interés por esta metodología. O objetivo deste artigo é apresentar parte dos resultados obtidos com a intervenção feita como projeto da dissertação de mestrado do autor, que consistiu no desenvolvimento de um conjunto de aulas de Astronomia, com alunos do 1º Ano do Ensino Médio de uma escola da rede privada do Distrito Federal (Brasília, Brasil), empregando como recurso principal um material didático chamado miniplanetário (MP). Utilizando como pressuposto teórico norteador dessas aulas as ideias de contextualização e dialogicidade de Paulo Freire, foi proposta aos estudantes a montagem e utilização desse recurso em uma sessão de planetário. Durante o projeto, enfatizaram-se assuntos como a trajetória aparente das estrelas para o céu de Brasília, a localização dos pontos cardeais a partir da constelação do Cruzeiro do Sul, as cores das estrelas e as estrelas vistas de uma determinada localidade. Apurou-se que os alunos apresentaram melhoria na compreensão desses assuntos, bem como demonstraram expressiva empolgação com essa metodologia desenvolvida.

  19. The Shadow of a Gnomon Along a Year: Routine Observations and Teaching of Apparent Motion of the Sun and the Four Seasons. (Spanish Title: La Sombra de un Gnomon lo Largo de un Ao: Observaciones de Rutina y la Enseanza del Movimiento Aparente del Sol y Las Cuatro Estaciones.) A Sombra de um Gnmon ao Longo de um Ano: Observaes Rotineiras e o Ensino do Movimento Aparente do Sol E das Quatro Estaes

    NASA Astrophysics Data System (ADS)

    Trogello, Anderson Giovani; Danhoni Neves, Marcos Cesar; de Carvalho Rutz da Silva, Sani

    2013-12-01

    Many misconceptions are recognized among the various groups of students, especially in the elementary school. Among them, the apparent motion of the Sun, in spite of its daily occurrence, is subject to varied interpretations. Thus, the observation and recording of the motion of the stars in the celestial vault is a necessary task for astronomy education. The work presented here proposes the presentation of the results of observations of the apparent movement of the sun by marking the shadow of a vertical gnomon by the students in a class of sixth graders of elementary rural school of Paran. The project itself was conducted in four stages, on dates near the March equinox, the June solstice, the September equinox and the December solstice. In addition, lectures were developed in the classroom. Such methods sought to build concepts around the apparent movement of the Sun and the alternation of the seasons. Given the results of the activities, an evaluation was applied and the data demonstrated a desired student learning such as: the recognition of the cardinal points, the description of the apparent solar motion and the occurrence of the seasons and their alternation from astronomical observations at naked eye. Muchos conceptos aternativos son conocidos entre los distintos grupos de alumnos, sobre todo en la educacin bsica. Entre ellos, el movimiento aparente del Sol, por ms cotidiano que sea, se presta a interpretaciones variadas. Por lo tanto, observar y registrar el movimiento de las estrellas en la bveda celeste se torna una tarea necesaria para la educacin en astronoma. El trabajo que aqu se presenta propone la presentacin de los resultados de la observacin del movimiento aparente del sol a travs de la marcacin de la sombra del gnomon vertical a cargo de los estudiantes en una divisin de sexto grado de de la escuela primaria rural de Paran. El proyecto en s se llev a cabo en cuatro etapas, en fechas cercanas al equinoccio de marzo, al solsticio de junio, al equinoccio de septiembre y al solsticio de diciembre. Adems, se dictaron clases tericas en la sala de aula. Estos mtodos buscaron construir conceptos en torno al movimiento aparente del Sol y la sucesin de las estaciones. Teniendo en cuenta los resultados de las actividades se aplic una evaluacin cuyos datos demuestran la existencia de un aprendizaje deseado por los estudiantes en cuanto a: el reconocimiento de los puntos cardinales, la descripcin del movimiento solar aparente y la aparicin de las estaciones y su alternancia a partir de observaciones astronmicas visuales sin instrumentos. Muitas concepes alternativas so reconhecidas entre os diversos grupos de estudantes, em especial nos da educao bsica. Dentre elas, o movimento aparente do Sol, por mais quotidiano que seja, proporciona variadas interpretaes. Deste modo, observar e registrar o movimento dos astros na abboda celeste uma tarefa necessria ao ensino de Astronomia. O trabalho que ora se apresenta prope a apresentao dos resultados da observao do movimento aparente do Sol por intermdio da marcao da sombra de um gnmon vertical por alunos de uma turma do sexto ano do ensino fundamental de uma escola do campo do Paran. O projeto em si ocorreu em quatro etapas, em datas prximas do equincio de maro, do solstcio de junho, do equincio de setembro e do solstcio de dezembro. Alm disso, foram desenvolvidas aulas tericas em sala de aula. Tais mtodos buscaram construir conceitos em torno da movimentao aparente do Sol e da alternncia das estaes do ano. Diante dos resultados provenientes das atividades desenvolvidas foi aplicada uma avaliao e os dados demonstraram um aprendizado desejado dos alunos quanto: ao reconhecimento dos pontos cardeais; descrio do movimento solar aparente e a ocorrncia das estaes do ano e sua alternncia a partir de observaes astronmicas a olho nu.

  20. High School Student's Alternative Conceptions About the Phenomenon of the Formation of the Moon Phases. (Spanish Title: Concepciones Alternativas de Alumnos de Educación Media Sobre el Fenómeno de Formación de las Fases de La Luna.) Concepções Alternativas de Alunos do Ensino Médio Sobre o Fenômeno de Formação das Fases da Lua

    NASA Astrophysics Data System (ADS)

    Iachel, Gustavo; Langhi, Rodolfo; Fernandes Scalvi, Rosa Maria

    2008-07-01

    Forty students, at ages between 14 and 18 years old, from three schools in Bauru city, were questioned about their alternative conceptions concerning the phenomenon of formation of the Moon Phases. It was observed that some of the pupils confound the phenomenon of the formation of the Moon Phases with the phenomenon of the formation of the lunar eclipses, others are unaware of the reason of the phenomenon, they present incoherent alternative conceptions of the reality or incomplete conceptions. The results found here are aimed at the teachers of Elementary Education and can be used as a subsidy for future development of new pedagogical methods. Cuarenta estudiantes, con edad entre 14 y 18 años, pertenecientes a tres escuelas de la ciudad de Bauru, fueron cuestionados sobre sus concepciones alternativas acerca del fenómeno de la formación de las fases de la Luna. Fue observado que algunos alumnos confunden el fenómeno de formación de las fases de la Luna con el fenómeno de formación de los eclipses lunares, otros desconocen el motivo delfenómeno, presentan concepciones alternativas incoherentes con la realidad o bien presentan concepciones incompletas. Los resultados aquí encontrados son destinados a los profesores de la Enseñanza Básica y podrán ser usados como ayuda para el futuro desarrollo de nuevos métodos pedagógicos. Quarenta estudantes, com idades entre 14 e 18 anos, pertencentes a três escolas da cidade de Bauru, foram questionados sobre suas concepções alternativas acerca do fenômeno de formação das fases da Lua. Foi observado que alguns dos alunos confundem o fenômeno da formação das fases da Lua com o fenômeno da formação dos eclipses lunares, outros desconhecem o motivo do fenômeno, apresentam concepções alternativas incoerentes com a realidade ou então concepções incompletas. Os resultados aqui encontrados são destinados aos professores do Ensino Básico e poderão ser usados como subsídio parafuturo desenvolvimento de novos métodos pedagógicos.

  1. Memories of Astronomy Education in Brazil: Clippings from the Discourses of Interviewed Researchers on the Subject. (Spanish Title: Memorias de la Educación en Astronomía en Brasil: Recortes de los Discursos de Investigadores Entrevistados Acerca del Tema ) Memórias da Educação em Astronomia no Brasil: Recortes a Partir das Falas de Pesquisadores Entrevistados sobre o Tema

    NASA Astrophysics Data System (ADS)

    Iachel, Gustavo; Nardi, Roberto

    2014-12-01

    This paper presents a historical retrospective concerning data from a research in Astronomy Education in Brazil, after 1973. It was organized on the basis of the speech analysis of national researchers considered references in this field by their peers. Furthermore, it was elaborated on the basis of other studies from the areas of Science Education, Physics and Astronomy. This historical overview was developed in order to facilitate understanding of the contexts in which the interviewed researchers have developed professionally. Moreover, we attempted to recover the memory of the growing field of research in Astronomy Education in the country. We believe that the history presented can help those trying to understand the past in an attempt to resolve current and future demands. Se presenta en este artículo una retrospectiva histórica referente a datos provenientes de la investigación en enseñanza de la astronomía en el Brasil, después de 1973, organizada sobre la base del análisis de los discursos de los investigadores nacionales considerados referencias en este campo, y también en la lectura de las publicaciones en las áreas de Enseñanza de las Ciencias, Física y Astronomía. Este repaso histórico se desarrolló con el fin de facilitar la comprensión de los contextos en los que los investigadores entrevistados se han desarrollado profesionalmente. Por otra parte, se intentó recuperar la memoria del creciente campo de la investigación en Educación en Astronomía en el país. Creemos que el relato presentado puede contribuir a quien trata de comprender el pasado, en un intento de resolver las demandas actuales y futuras. Relata-se neste artigo uma retrospectiva histórica referente a dados provenientes de pesquisa em Educação em Astronomia no país, pós 1973, organizada com base na análise das falas de pesquisadores considerados referências nacionais nesse campo, como também na leitura de publicações das áreas de ensino de Ciências, Física e Astronomia. Tal panorama histórico foi desenvolvido com o intuito de favorecer nossa compreensão sobre os contextos nos quais os pesquisadores entrevistados se desenvolveram profissionalmente. Ademais, buscou-se recobrar a memória do crescente campo de pesquisa em Educação em Astronomia no país. Entendemos que o histórico apresentado possa contribuir para com os que buscam entender o passado na tentativa de solucionar demandas atuais e futuras.

  2. Bring Back "Das Kapital" Punishment! Credit Crunch and the Fall of the "Knowledge Economy"

    ERIC Educational Resources Information Center

    Stronach, Ian; Clarke, John

    2010-01-01

    This article contrasts the collapse of the twin political certainties of the 20th century--"scientific socialism" (1989) and "scientific capitalism" (2008). Such a collapse restores Uncertainty to her throne, and brings back the need to radically rethink political possibilities for the future. (Contains 1 note.)

  3. Kepler, Galilei, the telescope and the consequences. (German Title: Kepler, Galilei, das Fernrohr und die Folgen)

    NASA Astrophysics Data System (ADS)

    Gaulke, Karsten; Hamel, Jrgen

    The papers of this volume are dedicated to Johannes Kepler, the astronomy of his time, and the consequences of his researches. They deal with the reception on the Copernican system of the world at the court of landgrave William IV in Kassel and the use of astronomy at a princely court in the 16th century, exemplified by the Kassel residence. Two contributions discuss a text fragment in Kepler's Astronomia Nova and the dimensions of the geo- and heliocentric systems of the world in Kepler's Mysterium Cosmographicum. Other contributions deal with mathematical aspects un Kepler's exchange of letters, the biography of Kepler's discussion partner Ph. Feselius, as well as the early reception of the Tabulae Rudolphinae in the calendar literature, telescopes in Kepler's time, Chr. Scheiner's optical theory of the eye, and finally in the continuation of the heliocentric world system by Otto von Guericke's natural philosophy and science. In conclusion, the documents of the planned call of Kepler to Rostock university, as well as the first publication of a recently found, hitherto unknown letter by Kepler.

  4. Symmetrien verlängern das Leben von Schrödingers Kätzchen

    NASA Astrophysics Data System (ADS)

    Braun, Daniel

    2000-11-01

    Wendet man die Quantenmechanik auf makroskopische Objekte an, gelangt man zu scheinbar paradoxen, der täglichen Erfahrung widersprechenden Schlussfolgerungen Eine "Schrödinger-Katze" ist ein berühmtes Beispiel hierfür Was genau ist eine Schrödinger-Katze, und warum hat nochniemand eine beobachtet?

  5. Consideracoes Extemporaneas acerca das Metodologias Qualitativas (Extemporaneous Considerations about Qualitative Methodology).

    ERIC Educational Resources Information Center

    Pucci, Bruno

    2000-01-01

    Considers the differences between quantitative and qualitative research. Cites some essays by Adorno when he was living in New York which led to the conclusion that empirical data has much to say and discusses the theoretical-methodological contributions in a recent master's thesis in education. (BT)

  6. Das Ende der Nacht [The End of the Night (2nd enlarged ed.)

    NASA Astrophysics Data System (ADS)

    Posch, Thomas; Hölker, Franz; Uhlmann, Thomas; Freyhoff, Anja

    2013-09-01

    We provide provide an overview of the history of lighting and of the problems arising from artificial lighting. The book covers the following topics: A brief history of light (ch. 1); night and light in cultural history (ch. 2); light pollution in central Europe (ch. 3); Moths and artificial lights (ch. 4); Artificial lighting and birds (ch. 5); Ocean turtles as victims of beach lighting (ch. 6); Moon light as a zeitgeber for the marine fauna (ch. 7); the influence of artificial light at night on freshwater ecology (ch. 8); artificial light and human health (ch. 9); the loss of the night in a 24 hours society (ch. 10).

  7. 50 CFR 648.10 - VMS and DAS requirements for vessel owners/operators.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... owners/operators. 648.10 Section 648.10 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT... vessel issued a limited access NE multispecies small vessel category or Handgear A permit that fishes in... this paragraph (e), that the new VMS unit is an operational approved system as described under §...

  8. 50 CFR 648.10 - VMS and DAS requirements for vessel owners/operators.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... owners/operators. 648.10 Section 648.10 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT... vessel issued a limited access NE multispecies small vessel category or Handgear A permit that fishes in... this paragraph (e), that the new VMS unit is an operational approved system as described under §...

  9. 50 CFR 648.10 - VMS and DAS requirements for vessel owners/operators.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... owners/operators. 648.10 Section 648.10 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT... vessel issued a limited access NE multispecies small vessel category or Handgear A permit that fishes in... this paragraph (e), that the new VMS unit is an operational approved system as described under §...

  10. 50 CFR 648.10 - VMS and DAS requirements for vessel owners/operators.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... owners/operators. 648.10 Section 648.10 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT... vessel issued a limited access NE multispecies small vessel category or Handgear A permit that fishes in... this paragraph (e), that the new VMS unit is an operational approved system as described under §...

  11. Auswirkungen einer Pipeline-Verlegung auf das marine Benthos im Tidebecken von Baltrum-Langeoog

    NASA Astrophysics Data System (ADS)

    van Bernem, K. H.

    1999-12-01

    In order to investigate possible effects on benthic communities resulting from the landfall of the “EU-ROPIPE” gas pipeline in areas of the Wadden Sea National Park of Lower Saxony the following seasonal surveys were carried out by the GKSS-Research-Centre during 1993 1997: a) Assessment of species number and abundance of subtidal and intertidal macrofauna, b) Intertidal documentation of demersal fish and decapod crab stocks, c) Intertidal assessment of species composition and abundance of microalgae. Sublittoral sampling was mainly carried out by bottom-grabs and box-dredges at about 120 locations recorded by GPS. Sediment cores of intertidal benthic communities at 6 locations were processed for macrofauna and microalgae. Species numbers and abundances of sublittoral benthic macrofauna decreased during 1994 as well in those areas directly affected as well as in areas 500 to 1000m removed from the construction activities. Most notably, the relatively high species richness of a hard-bottom community, rare in Wadden Sea areas, was strongly disturbed. During the same period the spatial distribution and abundance of intertidal filter feeders decreased as well as the abundance of vagile predating polychaetes and amphipods at locations situated near low tide level. A local stock of the low dispersive Goby ( Pomatoschistus microps) was nearly totally destroyed. Decreases in the abundances of juvenile Plaice ( Pleuronectes platessa) and decapod crabs ( Crangon crangon, Carcinus maenas) could only be shown during July/October 1994 in those areas of working activities which were directly connected to the tidal migration paths of these species. During 1994/95 numbers and abundances of diatom species prefering fine grained sediments with a high amount of organic material increased significantly. A recovery started immediately after conclusion of the refilling measures in 1995. A complete documentation of the community-resilience, however, was masked by fluctuations following the ice-winter in 1995/96.

  12. To perto de casa, to longe de ns: etnografia das novas margens no centro da urbe

    PubMed Central

    Fernandes, Por Lus

    2011-01-01

    Philippe Bourgois , desde 2007, Richard Perry University professor no Departamento de Antropologia e de Medicina Familiar e de Prticas Comunitrias na Universidade da Pensilvnia. Esteve durante largos anos ligado ao Departamento de Antropologia, Histria e Medicina Social da Universidade da Califrnia, So Francisco. A publicao, em 1995, de In Search of Respect: Selling Crack in El Barrio1 projectaria o seu nome muito para alm dos Estados Unidos: uma etnografia no corao porto-riquenho do Harlem, em torno dos actores e dos ambientes da venda de crack. Seguir-se-ia um longo trabalho de terreno em acampamentos de dependentes de herona em So Francisco, orientando o seu trabalho para as formas mais radicais da pobreza e da marginalidade nos EUA. deste trabalho de terreno que sai o seu ltimo livro, Righteous Dopefiend2. Em Junho de 2007 esteve em Lisboa para participar na 3.a edio do Ethnografeast. Foi ento que aproveitmos a oportunidade para ouvir um percurso invulgar contado pelo prprio: uma longa conversa no Hotel Zurique, cujo nome s vem ao caso por evocar o pas onde passou uma parte da infncia. PMID:22013286

  13. Verknpfung von DQ-Indikatoren mit KPIs und Auswirkungen auf das Return on Investment

    NASA Astrophysics Data System (ADS)

    Block, Frank

    Hufig ist nicht klar, welche Beziehungen zwischen Datenqualittsindikatoren (DQI, Definition folgt weiter unten) und Key Performance Indicators (KPI, s. Abschnitt 1.3 fr weitere Details) eines Unternehmens oder einer Organisation bestehen. Dies ist insbesondere deshalb von Bedeutung, da die Kenntnis dieser Beziehungen mageblich die Ausprgung eines Datenqualittsprojekts beeinflusst.

  14. O Universo das Sociedades Numa Perspectiva Relativa: Exercícios de Etnoastronomia

    NASA Astrophysics Data System (ADS)

    Fares, Érika Akel; Pessoa Martins, Karla; Maciel Araujo, Lidiane; Sauma Filho, Michel

    2004-12-01

    This work developed at the Planetarium of Pará employing workshops designed for visitor schools (public, private, specials groups), promotes the popularization of the Ethnoastronomy with the aim of diffusing values based on a cultural diversity tolerance and the need of harmonic interplay between people and environment. Using stories and debates, the relationship between humans and the Cosmos is traced from antiquity until today, with the help of slides as a didactic resource. Thus, many conceptions about the origin of the Universe are shown; as well as some constellations created along the History, ending with the present scientific manner of know and explain the World. We then demonstrate the links between space, time and culture with the Cosmos vision. The need to think the World within a plural context to create respect for other different persons is emphasized. Este trabalho, desenvolvido no Planetário do Pará através de oficinas com escolas visitantes (públicas, privadas e grupos especiais), promove a popularização da Etnoastronomia, com o objetivo de difundir valores pautados na tolerância à diversidade cultural e na necessidade da convivência harmônica entre o ser humano e o meio ambiente. Através da contação de histórias e promoção de debate, é tratada a relação dos humanos com o céu desde a antiguidade até os dias atuais, tendo como apoio didático o uso de slides. Assim, são mostradas diversas concepções de origem do Universo; algumas constelações criadas no decorrer da História; e a atual forma científica de conhecer e explicar o mundo. Demonstrando-se, então, a interligação entre espaço, tempo e cultura com a visão do Cosmo. Enfatiza-se a necessidade de se pensar o mundo numa perspectiva relativa ou plural, de forma a propiciar o respeito ao ser diferente.

  15. Zur Abschtzung des Einflusses knstlicher alpiner Stauseen auf das Klima ihrer Umgebung

    NASA Astrophysics Data System (ADS)

    Dobesch, H.

    1982-04-01

    The possible influence of man-made lakes in the Alpine Regions upon the climate of their surroundings is evaluated from simple climatological datas in two steps: firstly the calculation of the expected water surface temperature is demonstrated by several solutions of the equation of heat conduction with internal heat sources and then a simple diffusion model is applied for the transfer of the thermically modified and water vapour enriched air mass across the lake and the lee side inshore areas. The results show, that the modifications at lakes of small and medium size are relatively small, only in the immediate inshore areas they are marked more distinctly.

  16. Kindern das Wort Geben ein interkulturell-kreativer Arbeitsansatz, aufgezeigt an der Arbeit mit tibetischen Migrantenkindern

    NASA Astrophysics Data System (ADS)

    Rabkin, Gabriele

    2001-03-01

    Promotion of creativity in the cause of peace and international understanding is a fundamental part of the UNESCO programme to build a culture of peace. A central aspect of this undertaking consists in encouraging children to express themselves freely on this subject in writing and art. An approach has been developed to stimulate children's creativity and to create a link between creative expression and education for intercultural understanding. This article is divided into two parts. The first explains the pedagogical and psychological concepts behind this approach. The second describes a project in which these concepts were applied. It focuses on a minority dispersed over many parts of the world, namely children of Tibetan families. The description is accompanied by commentaries of the Fourteenth Dalai Lama, arising from a personal audience granted to the author in 1999.

  17. Der Haupthistokompatibilittskomplex und die Unterscheidung zwischen Selbst und Fremd durch das Immunsystem

    NASA Astrophysics Data System (ADS)

    Klein, Jan; Rammensee, Hans-Georg; Nagy, Zoltan A.

    1983-06-01

    The major histocompatibility complex (Mhc) is a cluster of closely linked genes which are involved in the distinction between self and non-self. The genes fall into two classes, I and II, which are evolutionarily related but specialized to performing somewhat different functions. The Mhc genes code for proteins which are seen together with foreign substances by the thymus-derived lymphocytes. These lymphocytes thus recognize simultaneously self (Mhc molecules) and non-self (foreign antigen). Some of the Mhc genes are highly polymorphic and this polymorphism probably represents a compensation for the fact that certain combinations of Mhc molecules and antigen fail to be recognized by the T lymphocyte.

  18. Blick in das kalte Weltall. Protosterne, Staubscheiben und schwarze Löcher.

    NASA Astrophysics Data System (ADS)

    Mezger, P. G.

    Contents: 1. Radioastronomie: Ein neues Fenster ins Weltall öffnet sich. Die Entwicklung der Radioastronomie. Vom Anfang der Welt: Der Urknall. Die Milchstraße und ihr infrarotes Bild. Sterne und interstellare Materie. Die Suche nach den Protosternen. Der Zentralbereich der Milchstraße. Im Zentrum der Milchstraße: Ein schwarzes Loch mit einer Akkretionsscheibe? 2. Der Wissenschaftsbetrieb.

  19. Das heissschlagverdichten ein neues verfahren zur herstellung keramischer brennstofftabletten mit engen formtoleranzen

    NASA Astrophysics Data System (ADS)

    Hrovat, M.; Mhling, G.; Rachor, L.; Vollath, D.; Zimmermann, H.

    1984-05-01

    The hot impact densification (HID) is a new powerful method for producing ceramic fuel pellets for nuclear reactors. Green ceramic bodies are directly processed to pellets by high speed shaping in the plastic temperature region of ceramic material. Opposed to the well established press sintering procedure it can be heated, densified, and cooled by orders of magnitude faster. Therefore, at high throughputs, small equipment dimensions become possible. The fuel pellets produced meet all requirements, particular the dimensional tolerances achieved are very closed, consequently circular grinding is omitted. Furthermore, the relatively high temperature level of the impact pressing favors the mixed crystal formation of uranium and plutonium oxide. This improves the solubility of the fuel in nitric acid, an essential point at reprocessing. A prototype facility is designed so that automatic fabrication in continuous operation will be possible. The target working cycle for a fuel pellet is in the range of some seconds.

  20. Das Werden des Kosmos. Von der Erfahrung der zeitlichen Dimension astronomischer Objekte im 18. Jahrhundert.

    NASA Astrophysics Data System (ADS)

    Krafft, F.

    This paper deals with two of the initial stages through which the dimension of time, in the sense of an irreversible development, found its way into astronomical-cosmological thinking. The one resulted from the first consequential application of Newtonian principles and laws to cosmic entities outside of our solar system found in the "General Natural History or Theory of the Heavens" by Immanuel Kant. The other initial stage is found in the classification of 'nebulae' by William Herschel who introduced the historical time factor as a principle of order in addition to the outward shape, which had become common for all the different elements in natural history during the second half of the 18th century.

  1. Diskrepanzen und Kongruenzen: Das Dilemma des afrikanischen Kindes zwischen Familie und Schule

    NASA Astrophysics Data System (ADS)

    Bauer, Annemarie

    1986-03-01

    This article expounds the theory that the failure of school is due to the incompatibility of the educational goals of school and traditional upbringing in Africa. The thesis is put forward by adherents of the psychoanalytical model of child development and seeks to emphasize the discrepancies between the childhood where children are not frustrated and where their needs are cared for and the school education which represses the drives and its socialization of children. Finding a number of anthropological studies are discussed and reinterpretations of the ethno-psychoanalytical materials attempted. Neither the evaluation of childhood in Africa nor the theory that with school come wholly new expectations of behaviour (e.g., a performance requirement) can no longer be maintained. In conclusion, other explanations for the difficulties encountered by school in Africa are offered.

  2. Das Studium: Vom Start zum Ziel: Lei(d)tfaden fr Studierende

    NASA Astrophysics Data System (ADS)

    Messing, Barbara

    Wer studieren will, hat viele Fragen und muss viele Entscheidungen treffen. Dieser Leitfaden hilft, eine Wahl zutreffen, sich an der Hochschule zurecht zu finden und Hrden rechtzeitig zu erkennen und zu bewltigen. Es geht um Fragen wie: Wer untersttzt mich finanziell? Studentenwohnheim oder WG? Was bringt eine Vorlesung? Wie komme ich an eine Abschlussarbeit - und wie schreibe ich sie? Weitere Themen sind: Struktur der Hochschule, Lebensabschnitt Studium, Motivation beim Lernen, Zeitmanagement im Studium, Recherchieren und Lesen, Verstehen und Entwickeln, Mathematik im Studium, Vortrge halten und Prfungen bestehen.

  3. Hepatologie Neuere Forschungsergebnisse in ihrer Bedeutung fr das Verstndnis von Leberkrankheiten

    NASA Astrophysics Data System (ADS)

    Gerok, W.; Blum, H. E.; Offensperger, W.; Offensperger, S.; Andus, T.; Gro, V.; Heinrich, P. C.

    1991-06-01

    By two exemplary clinical situations acute viral hepatitis, acute-phase reaction of the liver the significance of basic research for the understanding of clinical phenomena and for the development of new diagnostic and therapeutic procedures is demonstrated. The very different phenomena following infection with the hepatitis-B-virus can be explained by the variation in the interactions of virus and liver cell, by the immune reaction of the host, and by mutants of the virus. The reaction of the liver to an extrahepatic infection is mediated by interleukin-6, and characterized by an alteration in protein metabolism. The synthesis of acute-phase proteins is increased. The proteins confine the local injury and establish the homeostasis of the organism.

  4. Deutsch als Fremdsprachenphilologie: Das Heidelberger Modell (German as a Foreign Language Philology: The Heidelberg Model)

    ERIC Educational Resources Information Center

    Dietrich, Rainer; Heuer, Fritz

    1975-01-01

    German as a Foreign Language Philology is a new subject developed at the New Philology Faculty of the University of Heidelberg. Students whose native language is not German can earn a Master of Arts in this field. The study plan, educational goals, and the content and organization of the curriculum are described. (Text is in German.) (TL)

  5. Dermatomyositis: analysis of 109 patients surveyed at the Hospital das Clnicas (HCFMUSP), So Paulo, Brazil*

    PubMed Central

    Ortigosa, Luciena Cegatto Martins; dos Reis, Vitor Manuel Silva

    2014-01-01

    BACKGROUND Dermatomyositis affects striated muscles, skin and other organs. OBJECTIVE To characterize the disease from January 1992 to December 2002, assessing its classification, cutaneous and systemic manifestations, and also laboratory results, therapeutic and prognostic findings compared to those in the literature. METHODS Data were obtained from medical records of 109 patients who were classified into five groups: 23 juvenile dermatomyositis; 59 primary idiopathic dermatomyositis; 6 amyopathic dermatomyositis; 7 dermatomyositis associated with neoplasms and 14 dermatomyositis associated with other connective tissue diseases. RESULTS Sixty patients were classified as "definite" diagnosis; 33 as "possible"; four as "probable" and 12 and as amyopathic. The average age at diagnosis was 36 years. Cutaneous manifestations occurred in all patients; the most frequent symptom was loss of proximal muscle strength; the most common pulmonary disorder was interstitial lung disease, and gastritis was the most prevalent digestive manifestation. Tumors were documented in 6.42% of cases. Lactate dehydrogenase was the muscle enzyme most frequently elevated in the majority of cases. Skin biopsies were performed in 68 patients; muscle biopsies in 53; and electroneuromyographies in 58 patients. The most commonly used treatment was corticotherapy and the mortality rate was 14.7%. CONCLUSION in this sample, the disease appeared in younger individuals, was more frequent in women and the association with cancer was small. PMID:25184910

  6. 50 CFR 648.10 - VMS and DAS requirements for vessel owners/operators.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... OCEANIC AND ATMOSPHERIC ADMINISTRATION, DEPARTMENT OF COMMERCE FISHERIES OF THE NORTHEASTERN UNITED STATES... Bell Buoy “CC” 41°48.9′ 70°27.7′ 18. A point inside Cape Cod Bay 41°48.9′ 70°05′ 19. Race Point Lighted... SFMA, as provided in § 648.95; and (8) A vessel issued a limited access herring permit (i.e., All...

  7. A Integracao de Ensino das Ciencias da Saude (An Integrated Medical Education Program [in Brazil]).

    ERIC Educational Resources Information Center

    Pourchet-Campos, M. A.; Guimaraes Junior, Paulino

    At the Sixth Annual Reunion of the Brazilian Association of Medical Schools (VI Reuniao Anual da Associacao Brasileira de Escolas Medicas) leaders in the Brazilian medical profession proposed an integrated educational program for training students in the fields of medicine and public health. Under Brazil's present system of education, all…

  8. A Data Acquisition System (DAS) for marine and ecological research from aerospace technology

    NASA Technical Reports Server (NTRS)

    Johnson, R. A.

    1972-01-01

    The efforts of researchers at Mississippi State University to utilize space-age technology in the development of a self-contained, portable data acquisition system for use in marine and ecological research are presented. The compact, lightweight data acquisition system is capable of recording 14 variables in its present configuration and is suitable for use in either a boat, pickup truck, or light aircraft. This system will provide the acquisition of reliable data on the structure of the environment and the effect of man-made and natural activities on the observed phenomenon. Utilizing both self-contained analog recording and a telemetry transmitter for real-time digital readout and recording, the prototype system has undergone extensive testing.

  9. Fehler begehen - Mathematik verstehen ber die Bedeutung von Fehlern fr das Verstehen

    NASA Astrophysics Data System (ADS)

    Kser, Udo

    Auch wenn eine historisch oder systematisch umfassende Darstellung zur Fehlerthematik bislang nicht vorliegt, ist die Idee, einer Fehleranalyse unter der Leitfrage, welche Fehler von Schlerinnen und Schlern aufgrund welcher epistemologischen berzeugungen begangen werden, zentralen Raum fr die Betrachtung von Verstehensprozessen einzurumen, nicht neu. So ist es geradezu ein Charakteristikum einer modernen konstruktivistischen Didaktik, die eigenen Fehler von Lernenden als ihre individuellen Lerngelegenheiten zu begreifen, die einen wichtigen Motor fr den subjektiven Lernfortschritt bilden. Diese Sichtweise wurzelt aus psychologischer Perspektive in Analysen in der Tradition Piagets, der in Abkehr von einer quantitativen, psychometrischen Beschreibung kognitiver Prozesse, wie sie sich zum Beispiel in Intelligenztheorien nach Binet findet, qualitativ zu beschreiben versuchte, in welcher Weise Kinder und Jugendliche denken und urteilen. Doch auch schon in der klassischen Philosophie sind entsprechende Anstze zu finden. Prominente Beispiele hierfr sind die Idolenlehre Bacons und die Ideenlehre Platons.

  10. Das Gymnasium Zwischen Tradition und Modernen Bildungsanspruchen (The Gymnasium between Tradition and Modern Educational Requirements).

    ERIC Educational Resources Information Center

    Heller, Kurt A.

    2003-01-01

    Provides brief history of the German Gymnasium as a traditional European secondary school system with a preparatory function for higher education. Reviews the main goals of the gymnasium. Asks what role the gymnasium plays as a learning environment for gifted students. Discusses the politico-educational consequences and demands on the gymnasium.

  11. A Failed Utopia in Marcela Del Ro's "Proceso a Faubritten"

    ERIC Educational Resources Information Center

    Manickam, Samuel

    2014-01-01

    In Marcela del Ro's science fiction novel "Proceso a Faubritten," utopia comes in the form of eternal life for all of humanity, thanks to Dr. Alexander Faubritten's "Bomba L." This polyphonic work includes diaries by Faubritten and his Mexican lover, Mara Corona. In my analysis of these two diaries, I will show how

  12. A Failed Utopia in Marcela Del Río's "Proceso a Faubritten"

    ERIC Educational Resources Information Center

    Manickam, Samuel

    2014-01-01

    In Marcela del Río's science fiction novel "Proceso a Faubritten," utopia comes in the form of eternal life for all of humanity, thanks to Dr. Alexander Faubritten's "Bomba L." This polyphonic work includes diaries by Faubritten and his Mexican lover, María Corona. In my analysis of these two diaries, I will show how…

  13. The ??????????-riddle in Kepler's Astronomia Nova, chapter 57. (German Title: Das ??????????-Rtsel in Keplers Astronomia Nova, Kapitel 57)

    NASA Astrophysics Data System (ADS)

    Khn, Ernst

    Since 1937, the latin edition of Johannes Kepler's Astronomia Nova (1609) is available as a standard text. Here, in the 57th chapter, the third one of 48 important marginalia of Kepler, is reproduced as ?quo;Quae sit genuina et ?????????? mensura librationis huijus etc.. The Grecized word ?pi;???????? was ignored to a large extent by translators and commentators, and was at least declared enigmatic by Donahue (1992). A look in the original copies of the 1609 edition shows that it is written ???????????, not ? but a ??. ?????????? in KGW is a read error. In the context of Keplers natural, causal magnet-like forcesraquo; of planetary motion the conjecture ???????????? (as a typographical error a ? is omitted) immediately suggests itself: causally, aetiological. This solution of the ?????????? riddle indicates the tight brace between the important Chapter 57 of Kepler's celestial physics and and the complete title ASTRONOMIA NOVA ????????????, SEV PHYSICA COELESTIS etc.

  14. Werbung im Englischunterricht: Das Beispiel Einhorn - Onehorn - Unicorn (Advertising Material in English Teaching: The Example "Einhorn-Onehorn-Unicorn")

    ERIC Educational Resources Information Center

    Ruettgens, Hannelore

    1976-01-01

    Presents an advertisement from "Der Spiegel," composed in English that is saturated with Germanisms. Teaching procedures based on this are suggested: finding and classifying errors, composing alternative versions, translating into German, retranslating into English. Suggestions are given for further work based on the students' own experience.

  15. 50 CFR 648.53 - Acceptable biological catch (ABC), annual catch limits (ACL), annual catch targets (ACT), DAS...

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... requirements of the regulations in 50 CFR part 648. Upon denial of an application to transfer IFQ, the Regional... over up to 15 percent of the vessel's original IFQ plus the total of IFQ transferred to such vessel... other Internet sites as designated by the Regional Administrator. Instructions for electronic...

  16. Calibration of spectral video observations in the visual: theoretical overview of the ViDAS calibration pipeline

    NASA Astrophysics Data System (ADS)

    Zender, Joe; Koschny, Detlef; Ravensberg, Kevin

    2014-01-01

    During several campaigns, the ESA Meteor Research Group has collected a multitude of meteor spectral events using video intensified cameras with a spectral grating atop. The calibration of the individual movie frames towards time-resolved spectral information is still ongoing, and we try to achieve a semi-automatic data pipeline. We will describe the individual steps of the calibration pipeline to compute the (x, y) position of a wavelength in an image from the celestial coordinates of the meteor for a given time instance.

  17. Die physikalischen Umweltwissenschaften und das Militär Zur Erforschung Grönlands im Kalten Krieg

    NASA Astrophysics Data System (ADS)

    Heymann, Matthias

    Die modernen Umweltwissenschaften stehen heute im Mittelpunkt von Forschungsfrderung und ffentlicher Aufmerksamkeit. Im Zuge des seit den 1970er Jahren erwachten Interesses am globalen Wandel der Umwelt und den damit verknpften Problemen, ist ihre Bedeutung rasch gestiegen. Viele Wurzeln der modernen Umweltwissenschaften liegen jedoch im Kalten Krieg.

  18. M?jsaimniec?bu Ietekme uz Klimatu Latvij?: Oglek?a P?das R?d?t?js

    NASA Astrophysics Data System (ADS)

    Brizga, J.; Kudre?ickis, I.

    2009-01-01

    People more and more recognize climate change as one of the main environmental problems and the term `carbon footprint' (CF) has become popular and is now in widespread use. In this paper, the CF concept has been applied to analyse average per capita household Greenhouse Gas (GHG) emissions in Latvia. We explore household CF in housing (heating and electricity consumption), transport, food and goods and service sectors, which are the main household environmental pressure areas. This paper provides an understanding of both direct and indirect (embodied) GHG emissions. Results from the study suggest that the average Latvian exceeds its global fair share of GHG emissions - the average per capita GHG in 2006 was 4.35 t CO2e. The highest household emissions arise from housing (37%), mobility (26%) and food consumption (25%), goods and services together account only for 12% of total household GHG emissions. This study, however, does not cover capital investments in infrastructure (roads, public buildings etc.) which could increase total emission by almost a ton. The study emphasizes that attention must be paid to the lifestyles, infrastructure and institutions that result in considerable amounts of carbon being locked up in the household activities through which people meet their everyday needs. The findings also indicate that policies should be targeted at the segments in society responsible for the highest carbon footprints, ie. housing, food and mobility.

  19. Das Pinealorgan der Wirbeltiere: ein Modell für Untersuchungen von Rezeptor-und Effektormechanismen in neuronalen Systemen

    NASA Astrophysics Data System (ADS)

    Korf, Horst-W.; Wicht, Helmut

    1991-10-01

    Cell and molecular biological investigations have greatly contributed to our understanding of receptor and effector mechanisms in sensory, neuronal, and endocrine cells. A fascinating aspect of this line of research is how such mechanisms have evolved and how they interact with each other. As shown in this contribution, the vertebrate pineal organ is an interesting model to study these problems, because it undergoes a conspicuous transformation during phylogeny, comprises two well-chraracterized receptor mechanisms (photoreception and adrenoreception), and acts upon its targets via neuronal and neuroendocrine signals.

  20. Lematre, the expanding universe, and the cosmological constant (German Title: Lematre, das expandierende Universum und die kosmologische Konstante )

    NASA Astrophysics Data System (ADS)

    Roessler, Kurt

    The scientific and human relations of Albert Einstein and Georges Lematre are discussed. In 1927 the later had interpreted the general theory of relativity for a model of an expanding cosmos using a positive value of the cosmological constant. In the three open questions between them: expansion of cosmos, primordial state of a quantum vacuum (``primeval atom''), importance of the cosmological constant for vacuum energy, Lematre finally won over the heavily opposing Einstein. The philosophical and ontological tendency of Einstein's thinking was contrasted with the strict epistemological line of the catholic priest Lematre. The dramatic changes between friendship and controversy finally led to a diminution of Lematre's reputation as ``Darwin of Cosmology''. In that case, the late Einstein proved to be a hindrance rather than a promoter of evolution in cosmology.

  1. Ökophysik: Plaudereien über das Leben auf dem Land, im Wasser und in der Luft

    NASA Astrophysics Data System (ADS)

    Nachtigall, W.

    Prof. em. Dr. rer. nat. Werner Nachtigall, geb. 1934, war als Zoophysiologe und Biophysiker Leiter des Zoologischen Instituts der Universität des Saarlandes in Saarbrücken. In Forschung und Ausbildung hat er sich insbesondere mit Aspekten der Technischen Biologie und Bionik befasst und mit seinen Forschergruppen viele Basisdaten insbesondere zur Ökologie, Physiologie und Physik des Fliegens und Schwimmens aber auch zur Stabilität beispielsweise der Gräser erarbeitet. Lebewesen überraschen immer wieder durch ihre "Biodiversität", ihre hochspezifischen Ausgestaltungen und Anpassungen.

  2. Werbung im Englischunterricht: Das Beispiel Einhorn - Onehorn - Unicorn (Advertising Material in English Teaching: The Example "Einhorn-Onehorn-Unicorn")

    ERIC Educational Resources Information Center

    Ruettgens, Hannelore

    1976-01-01

    Presents an advertisement from "Der Spiegel," composed in English that is saturated with Germanisms. Teaching procedures based on this are suggested: finding and classifying errors, composing alternative versions, translating into German, retranslating into English. Suggestions are given for further work based on the students' own experience.…

  3. 50 CFR 648.53 - Acceptable biological catch (ABC), annual catch limits (ACL), annual catch targets (ACT), DAS...

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... failure to meet the requirements of the regulations in 50 CFR part 648. Upon denial of an application to... shall be: (i) 2011: 27,269 mt. (ii) 2012: 28,961 mt. (iii) 2013: 28,700 mt. (2) Scallop incidental catch... lb (22.7 mt) for fishing years 2011, 2012, and 2013. (3) Limited access fleet sub-ACL and ACT....

  4. 50 CFR 648.53 - Acceptable biological catch (ABC), annual catch limits (ACL), annual catch targets (ACT), DAS...

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... failure to meet the requirements of the regulations in 50 CFR part 648. Upon denial of an application to...) ABC/ACL for fishing years 2013 through 2014 shall be: (i) 2013: 21,004 mt (46,305,894 lb). (ii) 2014: 23,697 mt (52,242,942 lb). (iii) (2) Scallop incidental catch target TAC. The annual incidental...

  5. Integration and validation testing for PhEDEx, DBS and DAS with the PhEDEx LifeCycle agent

    NASA Astrophysics Data System (ADS)

    Boeser, C.; Chwalek, T.; Giffels, M.; Kuznetsov, V.; Wildish, T.

    2014-06-01

    The ever-increasing amount of data handled by the CMS dataflow and workflow management tools poses new challenges for cross-validation among different systems within CMS experiment at LHC. To approach this problem we developed an integration test suite based on the LifeCycle agent, a tool originally conceived for stress-testing new releases of PhEDEx, the CMS data-placement tool. The LifeCycle agent provides a framework for customising the test workflow in arbitrary ways, and can scale to levels of activity well beyond those seen in normal running. This means we can run realistic performance tests at scales not likely to be seen by the experiment for some years, or with custom topologies to examine particular situations that may cause concern some time in the future. The LifeCycle agent has recently been enhanced to become a general purpose integration and validation testing tool for major CMS services. It allows cross-system integration tests of all three components to be performed in controlled environments, without interfering with production services. In this paper we discuss the design and implementation of the LifeCycle agent. We describe how it is used for small-scale debugging and validation tests, and how we extend that to large-scale tests of whole groups of sub-systems. We show how the LifeCycle agent can emulate the action of operators, physicists, or software agents external to the system under test, and how it can be scaled to large and complex systems.

  6. Neuropatía persistente aumenta el riesgo de caídas entre supervivientes de cáncer

    Cancer.gov

    Muchas mujeres supervivientes de cáncer tienen problemas de movilidad y de otras funciones físicas como resultado de la neuropatía periférica persistente causada por el tratamiento de quimioterapia, según un estudio nuevo.

  7. Neues "Francais fondamental?" Das Europa-Projekt "Un niveau seuil." (A New "Francais fondamental?" The European Project "A Threshold Level").

    ERIC Educational Resources Information Center

    Raasch, Albert

    1978-01-01

    The project "Threshold Level," initiated by the Council of Europe in 1976, is compared with "Francais fondamental," comparing their aims and their differences. Offered as an interim statement, the article leaves open the question of whether Francais fondamental should be replaced by the the Threshold Level. (IFS/WGA)

  8. Late Holocene marine terraces of the Cartagena region, southern Caribbean: The product of neotectonism or a former high stand in sea-level?

    NASA Astrophysics Data System (ADS)

    Ignacio Martnez, J.; Yokoyama, Yusuke; Gomez, Andres; Delgado, Adriana; Matsuzaki, Hiroyuki; Rendon, Esteban

    2010-03-01

    The detailed stratigraphic survey and paleontological study (mollusks, corals, foraminifera and ostracods) of four low-level, 3 m, marine terrace sections: Punta Canoas, Manzanillo del Mar, Playa de Oro, and Tierra Bomba Island, from the Cartagena region, southern Caribbean, supplemented with 22 radiocarbon dates, reveals that the northern terraces were deposited as parasequences in a clastic depositional system compared to the Tierra Bomba Island succession that was deposited in a carbonate depositional system between 3600 and 1700 cal yrs BP. Drier conditions and the southern location of the ITCZ at about 3 ka triggered stronger easterly Trades and more dynamic southwestward sediment drift fed by the Magdalena River mouth, thus promoting the formation of sand spits that ultimately isolated the Cienaga de Tesca coastal lagoon from the Caribbean Sea. Our estimates support the hypothesis that the present position of the terraces is the product of neotectonism rather than a higher 3 ka, sea-level. Upheaval of the terraces varies between 3.8 mmyr -1 at Punta Canoas and 2.2 mmyr -1 at Tierra Bomba to 1.5 mmyr -1 at Manzanillo del Mar and Playa de Oro terraces. Our study corroborates previous contentions on the role of mud diapirism and the dynamics of the Dique Fault as late Holocene upheaval mechanisms.

  9. Evidence and consensus based guideline for the management of delirium, analgesia, and sedation in intensive care medicine. Revision 2015 (DAS-Guideline 2015) - short version.

    PubMed

    Baron, Ralf; Binder, Andreas; Biniek, Rolf; Braune, Stephan; Buerkle, Hartmut; Dall, Peter; Demirakca, Sueha; Eckardt, Rahel; Eggers, Verena; Eichler, Ingolf; Fietze, Ingo; Freys, Stephan; Frnd, Andreas; Garten, Lars; Gohrbandt, Bernhard; Harth, Irene; Hartl, Wolfgang; Heppner, Hans-Jrgen; Horter, Johannes; Huth, Ralf; Janssens, Uwe; Jungk, Christine; Kaeuper, Kristin Maria; Kessler, Paul; Kleinschmidt, Stefan; Kochanek, Matthias; Kumpf, Matthias; Meiser, Andreas; Mueller, Anika; Orth, Maritta; Putensen, Christian; Roth, Bernd; Schaefer, Michael; Schaefers, Rainhild; Schellongowski, Peter; Schindler, Monika; Schmitt, Reinhard; Scholz, Jens; Schroeder, Stefan; Schwarzmann, Gerhard; Spies, Claudia; Stingele, Robert; Tonner, Peter; Trieschmann, Uwe; Tryba, Michael; Wappler, Frank; Waydhas, Christian; Weiss, Bjoern; Weisshaar, Guido

    2015-01-01

    In 2010, under the guidance of the DGAI (German Society of Anaesthesiology and Intensive Care Medicine) and DIVI (German Interdisciplinary Association for Intensive Care and Emergency Medicine), twelve German medical societies published the "Evidence- and Consensus-based Guidelines on the Management of Analgesia, Sedation and Delirium in Intensive Care". Since then, several new studies and publications have considerably increased the body of evidence, including the new recommendations from the American College of Critical Care Medicine (ACCM) in conjunction with Society of Critical Care Medicine (SCCM) and American Society of Health-System Pharmacists (ASHP) from 2013. For this update, a major restructuring and extension of the guidelines were needed in order to cover new aspects of treatment, such as sleep and anxiety management. The literature was systematically searched and evaluated using the criteria of the Oxford Center of Evidence Based Medicine. The body of evidence used to formulate these recommendations was reviewed and approved by representatives of 17 national societies. Three grades of recommendation were used as follows: Grade "A" (strong recommendation), Grade "B" (recommendation) and Grade "0" (open recommendation). The result is a comprehensive, interdisciplinary, evidence and consensus-based set of level 3 guidelines. This publication was designed for all ICU professionals, and takes into account all critically ill patient populations. It represents a guide to symptom-oriented prevention, diagnosis, and treatment of delirium, anxiety, stress, and protocol-based analgesia, sedation, and sleep-management in intensive care medicine. PMID:26609286

  10. Längengrad. Die wahre Geschichte eines einsamen Genies, welches das größte wissenschaftliche Problem seiner Zeit löste.

    NASA Astrophysics Data System (ADS)

    Sobel, D.

    This book is a German translation, by M. Fienbork, from the American original "Longitude", published in 1995. It tells the story of John Harrison (1693 - 1776), the inventor of a chronometer for precise time determination onboard of ships.

  11. Antarktis: Das CCAMLR-bereinkommen (Convention on the Conservation of Antarctic Marine Living Resources) und die illegale berfischung der sdlichen Ozeane

    NASA Astrophysics Data System (ADS)

    Siegel, Volker

    1999-12-01

    The Convention for the Conservation of Antarctic Marine Living Resources (CCAMLR) was ratified in 1982. This Convention was established in the light of a rapidly developing krill fishery in the 1970s. The objectives of the Convention are the rational use of marine living resources as well as the conservation of the resources and the marine ecosystem. Establishing the principle of the ecosystem approach has been rather progressive in fisheries conventions. From the bery beginning CCAMLR had to deal with problems of over-exploited fish stock from the unregulated fishery of pre-CCAMLR times. Antarctic cod and icefish stock were already heavily harvested or even showed signs of overfishing. Conservation measures and the closure of subareas for several years did not always lead to satisfactorily results. While some stock of icefish recovered to the extent, that a new fishery on a low level could be re-opened, other icefish stocks and especially Antarctic cod stocks have not recovered from this early depletion. A new dimension in the fishery developed in the mid 1990s, when very conservative conservation measures were introduced for the Dissostichus (toothfish), but due to the high commercial value a large illegal fishery developed rapidly in the Convention area. One additional problem of managing the longline fishery for toothfish is the by-catch and incidental mortality of sea-birds, for which special measures were established to avoid sea-bird mortality. The compliance with the measures and the elimination of the illegal fishery require strong actions of the Commission, the political decision-making body of CCAMLR. A future challange for CCAMLR could be the potentially expanding krill fishery. In the understanding of a precautionary approach, the scientific body of CCAMLR has already started to collect biological data and develop management and monitoring models for this fishery.

  12. Das Buchwesen im Spannungsfeld der Neuen Medien: Forschungs-, Lehr- und Berufsfelder (Bookmaking in a Changing Field of New Media: Research, Instruction and Professional Spheres).

    ERIC Educational Resources Information Center

    Simon, Hans-Reiner

    Recognizing that jobs are changing quickly during this second revolution of bookmaking and printing and that students must become aware of the new information technologies before they graduate, this brief report written in German presents examples of how to develop research and education in the study of books and printing using the most up-to-date

  13. Conceptual design of the CZMIL data acquisition system (DAS): integrating a new bathymetric lidar with a commercial spectrometer and metric camera for coastal mapping applications

    NASA Astrophysics Data System (ADS)

    Fuchs, Eran; Tuell, Grady

    2010-04-01

    The CZMIL system is a new generation airborne bathymetric and topographic remote sensing platform composed of an active lidar, passive hyperspectral imager, high resolution frame camera, navigation system, and storage media running on a linux-based Gigabit Ethernet network. The lidar is a hybrid scanned-flash system employing a 10 KHz green laser and novel circular scanner, with a large aperture receiver (0.20m) having multiple channels. A PMT-based segmented detector is used on one channel to support simultaneous topographic and bathymetric data collection, and multiple fields-of- view are measured to support bathymetric measurements. The measured laser returns are digitized at 1 GHz to produce the waveforms required for ranging measurements, and unique data compression and storage techniques are used to address the large data volume. Simulated results demonstrate CZMIL's capability to discriminate bottom and surface returns in very shallow water conditions without compromising performance in deep water. Simulated waveforms are compared with measured data from the SHOALS system and show promising expected results. The system's prototype is expected to be completed by end of 2010, and ready for initial calibration tests in the spring of 2010.

  14. Bestimmung astronomischer Lngendifferenzen fr das europische Lngennetz im Jahr 1980. Relative Rektaszensionsverbesserungen fr 125 Sterne des FK4 und FK4 Sup.

    NASA Astrophysics Data System (ADS)

    Kaniuth, K.; Wende, W.

    In context with the establishment of a modern astronomical longitude reference system in Europe longitude differences between national reference stations of the Federal Republic of Germany, Portugal and Spain have been measured by the authors with a Danjon-Astrolabe in 1980. The adjustment of the observations in two modes is described; the internal accuracy of the longitude differences is about 0s.0011. The relative right ascension corrections of FK4- and FK4 Sup-stars derived from the observations are discussed together with those already obtained from measurements between 1977 and 1979.

  15. Natural convection in a horizontal cylindrical annulus filled with a porous medium saturated by a nanofluid using Tiwari and Das' nanofluid model

    NASA Astrophysics Data System (ADS)

    Sheremet, M. A.; Pop, Ioan

    2015-06-01

    This paper deals with a numerical study of natural convection flow and heat transfer inside a concentric horizontal annulus filled with a porous medium saturated by a cuprum (Cu)-water nanofluid. The inner and outer cylinders are kept at different constant temperatures. First, the governing partial differential equations in dimensional formulation in a polar coordinate system for the physical domain are transformed in dimensionless form in terms of stream function-temperature formulation. These equations along with the corresponding boundary conditions were solved numerically by the finite difference method. Particular efforts have been focused on the effects of the Rayleigh number, porosity of the porous medium, solid volume fraction parameter of nanoparticles, annulus radius ratio, and the solid matrix of the porous medium (glass balls and aluminum foam) on the local and average Nusselt numbers, streamlines and isotherms. It is found that a very good agreement exists between the present results and those from the open literature.

  16. Comment on `Magnitude conversion problem using general orthogonal regression' by H. R. Wason, Ranjit Das and M. L. Sharma, (Geophys. J. Int., 190, 1091-1096)

    NASA Astrophysics Data System (ADS)

    Gasperini, Paolo; Lolli, Barbara

    2014-01-01

    The argument proposed by Wason et al. that the conversion of magnitudes from a scale (e.g. Ms or mb) to another (e.g. Mw), using the coefficients computed by the general orthogonal regression method (Fuller) is biased if the observed values of the predictor (independent) variable are used in the equation as well as the methodology they suggest to estimate the supposedly true values of the predictor variable are wrong for a number of theoretical and empirical reasons. Hence, we advise against the use of such methodology for magnitude conversions.

  17. Our Day-Care Centers Respect Children: Quality Criteria for Day-Care = Criterios para um Atendimento em Creches que Respeite os Direitos Fundamentais das Criancas.

    ERIC Educational Resources Information Center

    Campos, Maria Malta; Rosemberg, Fulvia

    Prepared as part of an effort to attain minimum quality standards for Brazilian day care centers, this document focuses on day-to-day provision of day care services for children from birth to 6 years old as well as broader day care administrative concerns. The first version of this document was prepared as part of a training project for day care

  18. "About the Telescope" and other manuscripts of lectures by Christoph Scheiner. (German Title: "ber das Fernrohr" und weitere Mitschriften von Vorlesungen Christoph Scheiners)

    NASA Astrophysics Data System (ADS)

    Daxecker, Franz

    "About the Telescope" is a manuscript of a lecture which was held by Christoph Scheiner in Ingolstadt around 1615. It has been translated from Latin. The manuscript gives an account of the invention, the construction, the manufacture and the use of the telescope. There is also a reference to 3 more manuscripts (19 topics about astronomy and physics) of his lectures.

  19. The Women's College (Hochschule fur das weibliche Geschlect) and its Impact on the Development of Higher Education for Girls in the City of Hamburg.

    ERIC Educational Resources Information Center

    Kleinau, Elke

    1990-01-01

    Reports a study on the Women's College founded in Hamburg, Germany, in 1850. Describes the college as an outgrowth of numerous reform-oriented forces present in Germany around 1848. Examines the impact of the college on higher education for girls in Hamburg; particularly in the establishment of further schools for poor women. (RW)

  20. Investigacao sobre as Formas de Raciocinio Silogistico no Contexto das Dificuldades de Aprendizagem (Investigation on the Forms of Syllogistic Logic in the Context of Learning Difficulties).

    ERIC Educational Resources Information Center

    Pagotti, Antonio Wilson

    2000-01-01

    Investigates forms of logical thinking in 75 students from three fifth-grade classes. Uses as instruments categorical and propositional syllogisms with unknown, doubtful, and contradictory facts. Shows relevant differences among the three classes, with increasing difficulties at resolution between the categorical and propositional syllogisms.

  1. Vom Gehilfen zum Helfer. Das Thema der Mitmenschlichkeit in Bernard Malamuds "The Assistant" (From "Assistant" to Helper. The Theme of Mutual Helpfulness in Bernard Malamud's "The Assistant").

    ERIC Educational Resources Information Center

    Hergt, Tobias

    1978-01-01

    Recommends, for teaching English in the upper grades, Malamud's "The Assistant," which deals with the life of a minority group in New York during the Great Depression, and which emphasizes the importance of neighborliness and mutual helpfulness. (IFS/WGA)

  2. Georg Philipp Harsdrffer, the first astronomical card game, and the Christian constellations (German Title: Georg Philipp Harsdrffer, das erste astronomische Kartenspiel und die christlichen Sternbilder)

    NASA Astrophysics Data System (ADS)

    Gaab, Hans

    The first astronomical card game was issued in Nuremberg in 1656. Its author was the lawyer, writer and literary theoretican Georg Philipp Harsdouml;rffer (1607-1658), who is primarily remembered as the inventor of the Nuremberg funnel. It is possible that a second card game was issued in the same year, but the sources are ambiguous. After some preliminaries on the history of card games, Harsdrffer's pack of cards is presented. In addition, general remarks about the history of sky maps are given.

  3. Evidence and consensus based guideline for the management of delirium, analgesia, and sedation in intensive care medicine. Revision 2015 (DAS-Guideline 2015) – short version

    PubMed Central

    Baron, Ralf; Binder, Andreas; Biniek, Rolf; Braune, Stephan; Buerkle, Hartmut; Dall, Peter; Demirakca, Sueha; Eckardt, Rahel; Eggers, Verena; Eichler, Ingolf; Fietze, Ingo; Freys, Stephan; Fründ, Andreas; Garten, Lars; Gohrbandt, Bernhard; Harth, Irene; Hartl, Wolfgang; Heppner, Hans-Jürgen; Horter, Johannes; Huth, Ralf; Janssens, Uwe; Jungk, Christine; Kaeuper, Kristin Maria; Kessler, Paul; Kleinschmidt, Stefan; Kochanek, Matthias; Kumpf, Matthias; Meiser, Andreas; Mueller, Anika; Orth, Maritta; Putensen, Christian; Roth, Bernd; Schaefer, Michael; Schaefers, Rainhild; Schellongowski, Peter; Schindler, Monika; Schmitt, Reinhard; Scholz, Jens; Schroeder, Stefan; Schwarzmann, Gerhard; Spies, Claudia; Stingele, Robert; Tonner, Peter; Trieschmann, Uwe; Tryba, Michael; Wappler, Frank; Waydhas, Christian; Weiss, Bjoern; Weisshaar, Guido

    2015-01-01

    In 2010, under the guidance of the DGAI (German Society of Anaesthesiology and Intensive Care Medicine) and DIVI (German Interdisciplinary Association for Intensive Care and Emergency Medicine), twelve German medical societies published the “Evidence- and Consensus-based Guidelines on the Management of Analgesia, Sedation and Delirium in Intensive Care”. Since then, several new studies and publications have considerably increased the body of evidence, including the new recommendations from the American College of Critical Care Medicine (ACCM) in conjunction with Society of Critical Care Medicine (SCCM) and American Society of Health-System Pharmacists (ASHP) from 2013. For this update, a major restructuring and extension of the guidelines were needed in order to cover new aspects of treatment, such as sleep and anxiety management. The literature was systematically searched and evaluated using the criteria of the Oxford Center of Evidence Based Medicine. The body of evidence used to formulate these recommendations was reviewed and approved by representatives of 17 national societies. Three grades of recommendation were used as follows: Grade “A” (strong recommendation), Grade “B” (recommendation) and Grade “0” (open recommendation). The result is a comprehensive, interdisciplinary, evidence and consensus-based set of level 3 guidelines. This publication was designed for all ICU professionals, and takes into account all critically ill patient populations. It represents a guide to symptom-oriented prevention, diagnosis, and treatment of delirium, anxiety, stress, and protocol-based analgesia, sedation, and sleep-management in intensive care medicine. PMID:26609286

  4. Das Bin Ich. Ein Buch von mir uber mich (It's Me! A Book By and About Myself). Communicative Activities for German Immersion and Second Language Classes.

    ERIC Educational Resources Information Center

    Wicke, Mariele; Wicke, Rainer

    This workbook is intended as a text for the learner of German as a foreign language. The workbook is complete with exercises that require students to provide information about themselves. Students provide information by reading questions and filling in the blanks. Questions are asked about families, friends, likes and dislikes, hobbies, and even

  5. Kooperatives Lernen lernen? Zur Diskussion uber das Bildungswesen in Japan (Learning Cooperative Learning? On the Discussion of the Japanese Educational System).

    ERIC Educational Resources Information Center

    Schubert, Volker

    1998-01-01

    Suggests a reconsideration of the criticism of Japanese competition against the background of the Japanese educational system's highly developed learning culture. Considers some of the basic aspects of group-oriented communal learning in school, while also cautioning against a "monocausal" culturalism. (Author/CMK)

  6. Health Information on Internet: Quality, Importance, and Popularity of Persian Health Websites

    PubMed Central

    Samadbeik, Mahnaz; Ahmadi, Maryam; Mohammadi, Ali; Mohseni Saravi, Beniamin

    2014-01-01

    Background: The Internet has provided great opportunities for disseminating both accurate and inaccurate health information. Therefore, the quality of information is considered as a widespread concern affecting the human life. Despite the increasingly substantial growth in the number of users, Persian health websites and the proportion of internet-using patients, little is known about the quality of Persian medical and health websites. Objectives: The current study aimed to first assess the quality, popularity and importance of websites providing Persian health-related information, and second to evaluate the correlation of the popularity and importance ranking with quality score on the Internet. Materials and Methods: The sample websites were identified by entering the health-related keywords into four most popular search engines of Iranian users based on the Alexa ranking at the time of study. Each selected website was assessed using three qualified tools including the Bomba and Land Index, Google PageRank and the Alexa ranking. Results: The evaluated sites characteristics (ownership structure, database, scope and objective) really did not have an effect on the Alexa traffic global rank, Alexa traffic rank in Iran, Google PageRank and Bomba total score. Most websites (78.9 percent, n = 56) were in the moderate category (8 ? x ? 11.99) based on their quality levels. There was no statistically significant association between Google PageRank with Bomba index variables and Alexa traffic global rank (P > 0.05). Conclusions: The Persian health websites had better Bomba quality scores in availability and usability guidelines as compared to other guidelines. The Google PageRank did not properly reflect the real quality of evaluated websites and Internet users seeking online health information should not merely rely on it for any kind of prejudgment regarding Persian health websites. However, they can use Iran Alexa rank as a primary filtering tool of these websites. Therefore, designing search engines dedicated to explore accredited Persian health-related Web sites can be an effective method to access high-quality Persian health websites. PMID:24910795

  7. Hilfe zur Selbsthilfe: Das Leitmotiv eines neuen Fortbildungsmodells fur DaF in Kanada (Helping Others To Help Themselves: The Dominant Theme of a New Model of Continuing Education for German as a Foreign Language in Canada).

    ERIC Educational Resources Information Center

    Enns, Esther E.

    1996-01-01

    Describes the new direction in Canadian continuing education for German teachers. Autonomous learning and collegial collaboration at the regional level are at the center of this re-orientation. At the national level, networking among regionally-active teacher groups that will lead to a new organizational structure and to new forms of cooperation

  8. On the construction of a 2-metre mirror blank for the universal reflecting telescope in Tautenburg (German Title: ber die Fertigung eines 2-Meter-Spiegeltrgers fr das Universal-Spiegelteleskop in Tautenburg )

    NASA Astrophysics Data System (ADS)

    Ldel, Wolfgang

    The astronomers' desire to penetrate deeper into space transforms into a demand for larger telescopes. The primary mirror constitutes the main part of a reflecting telescope, and it determines all subsequent activities. Already in the 1930s activities existed in the Schott company to manufacture mirror blanks up to diameters of 2 metres, which could not be pursued because of political constraints. This ambitious goal was again picked up a few years after the war. At a time when the procurement of raw materials was extremely difficult, the glass workers of Schott in Jena attacked this large project. After some failures, a good mirror blank could be delivered to the Carl Zeiss Company in 1951 for further processing and for the construction of the first 2-metre reflecting telescope. From 1960 to 1986, this mirror made from optical glass ZK7 served its purpose at the Karl Schwarzschild Observatory in Tautenburg. lt was then replaced by a zero expansion glass ceramics mirror.

  9. "A talented young man" - The short life of Friedrich Wilhelm Tnnies, 1796-1817; (German Title: "Ein talentvoller junger Mann" - Das kurze Leben des Friedrich Wilhelm Tnnies, 1796-1817)

    NASA Astrophysics Data System (ADS)

    Schwemin, Friedhelm

    Friedrich Wilhelm Tnnies' name is hardly found in the major histories of astronomy. This is not surprising since he died before the age of twenty-one. Nevertheless, and perhaps because he knew at heart that not much time was granted to him, he left an astonishingly prolific oeuvre which indicates his rich talents. His contemporaries also testify that this son af a wealthy textile merchant had a great talent. But it is idle to speculate whether he would have become a second Bessel, or just an inconspicuous high school teacher in some remote Prussian province. He experienced a decisive career advancement by the Berlin astronomer J.E. Bode, obtained his Ph.D. already at the age of nineteen, published, among other things, about the large solar eclipse of November 19, 1816, and corresponded with several professional astronomers, before he succumbed to a pulmonary disease.

  10. Biologie und Fremdsprachenunterricht. Das Prinzip der Einsprachigkeit im Lichte biologischer Erkenntnisse ueber Denken und Lernen (Biology and Foreign Language Teaching. The Monolingual Principle in the Light of Biological Findings concerning Thinking and Learning).

    ERIC Educational Resources Information Center

    Schneider, Rudolf

    1979-01-01

    Draws upon recent publications dealing with brain function (particularly F. Vester, "Denken, Lernen, Vergessen", Munich, 1978) for ideas for foreign language teaching. These include constant use of the foreign language in the classroom, frequent repetition, and avoidance of false associations by explanation in the native language. (IFS/WGA)

  11. Der Zitier-Index (Science-Citation-Index): Eine Datenbank fur das Ermitteln von neuen Ideen und Konzepten (The Science Citation Index: A Database for the Discovery of New Ideas and Concepts).

    ERIC Educational Resources Information Center

    Simon, Hans-Reiner; Thormann, K.-D.

    This report discusses the use of the Science Citation Index produced by the Institute for Scientific Information (ISI) as a given "expert system" in the experimental study of different search levels. The inquiry has two objectives: (1) to test whether a "traditional" information system will also produce the rudiments of a knowledge-based system;

  12. Lehrer in der Bundesrepublik Deutschland. Eine Kritische Analyse Statistischer Daten uber das Lehrpersonal an Allgemeinbildenden Schulen. (Education in the Federal Republic of Germany. A Statistical Study of Teachers in Schools of General Education.)

    ERIC Educational Resources Information Center

    Kohler, Helmut

    The purpose of this study was to analyze the available statistics concerning teachers in schools of general education in the Federal Republic of Germany. An analysis of the demographic structure of the pool of full-time teachers showed that in 1971 30 percent of the teachers were under age 30, and 50 percent were under age 35. It was expected that

  13. Landeskunde im Englischunterricht der Sekundarstufe 1. Das Arbeiten mit verschiedenen Lehrbuchtexten zum Rassenproblem (Area Studies in English Courses in Grades 5-10. Working with Different Teaching Texts Dealing with the Race Problem)

    ERIC Educational Resources Information Center

    Redling, Julius

    1977-01-01

    Using material on race discrimination in the United States from three textbooks, a procedure for text analysis is demonstrated, including such matters as the "tone" of communication, the implications in the words used, bearing on conditions in the culture, etc. (Text is in German.) (IFS/WGA)

  14. Das Licht am Ende des Tunnels: Motivationsstrukturen fur den Deutschunterricht Reflexionen uber ein altes und stets neues Problem (The Light at the End of the Tunnel: Structures for Motivating German Teaching. Reflections on an Old and Continually New Problem).

    ERIC Educational Resources Information Center

    Classen, Albrecht

    2001-01-01

    Argues that despite the decline in enrollments in German at elementary and secondary schools and colleges and universities, there is reason to hope that interest can be invigorated. Suggests that there are easy instructional methods and materials for developing a new motivation in learning the language. (Author/VWL)

  15. [Hand injuries by pyrotechnic articles--case report and reconstructive experimental investigations].

    PubMed

    Schröder, Ann Sophie; Jahnke, Philipp; Hessler, Christian; Lockemann, Ute

    2014-01-01

    Injuries caused by explosions of fireworks often involve people's hands. The case of a young man who suffered severe hand injuries as well as damage to both eardrums and one eye is described. Reconstructive experimental investigations of the explosive effect of six different pyrotechnic articles were carried out using human hands from body donors. With the most powerful firecrackers that used to be legally available in Germany ("Super-Böller A", "Kanonenschlag") and a self-made one with 36 g gunpowder only blackening of the skin occurred. Three pyrotechnic articles not allowed in Germany ("La Bomba", "Color salute" and "Vogelschreck") caused serious injury to the hand's soft tissue and bones. PMID:25122993

  16. Astronomie für die Praxis. Band 2: Einführung in die Theorie.

    NASA Astrophysics Data System (ADS)

    Wischnewski, E.

    Contents: 1. Physikalische Grundlagen. 2. Das Sonnensystem. 3. Das Werden der Sterne. 4. Das Sterben der Sterne. 5. Besondere Sterne. 6. Gasnebel im Weltall. 7. Unsere Milchstraße und andere Galaxien. 8. Andere Möglichkeiten der Beobachtung.

  17. 78 FR 4391 - New England Fishery Management Council; Public Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-22

    ... system based on days-at-sea (DAS) and trip limits. These changes may include adoption of a DAS leasing program, and in that context, the NMFS Regional Office staff will give a presentation on the DAS...

  18. Vom Urknall zum Zerfall. Die Welt zwischen Anfang und Ende.

    NASA Astrophysics Data System (ADS)

    Fritzsch, H.

    Contents: Der Tanz mit dem Ozean. Galaktische Landkarte. Das Ma der Dinge. Der wrfelnde Gott der Quantenphysik. Geheimnisvolle Felder. Materie und Antimaterie. Quarks - Urstoff unserer Welt. Zerfallende Protonen und die Einheit der Physik. Der Zauberofen. Das berschaubare Universum. Das explodierende Universum. Nachhall der Schpfung. Der achtfache Weg der kosmischen Entwicklung. Das Ende der Welt. Einheit in der Vielfalt. Das geistige Universum. Gott und das absurde Universum.

  19. 48 CFR 330.201-5 - Waiver.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... waiver requests through appropriate acquisition channels, including the HCA, to the Associate DAS for Acquisition (non-delegable) for review. Associate DAS for Acquisition shall exercise the waiver...

  20. 48 CFR 801.304 - Department control and compliance procedures.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... designated as the Department's Chief Acquisition Officer. The Deputy Assistant Secretary (DAS) for... Associate DAS for Acquisitions is designated as the Deputy Senior Procurement Executive (DSPE). The DSPE...

  1. 24 CFR 17.109 - Review procedures.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... Secretary (DAS) or designee conducts the hearing. The DAS or designee will take steps necessary to ensure that the hearing is conducted in a fair and expeditious manner. If necessary, the DAS or designee may administer oaths of affirmations. (2) The DAS or designee does not use the formal rules of evidence...

  2. Elektrotechnik

    NASA Astrophysics Data System (ADS)

    Bge, Gert

    Ursprnglicher Sitz der Elektrizitt ist das Atom. Das Wasserstoffatom z.B. besteht aus einem Proton als Kern und einem Elektron, das diesen Kern auf einer bestimmten Bahn umkreist. Das Proton bezeichnet man als elektrisch positiv, - das Elektron als negativ geladen. Zwischen beiden befindet sich die "Elektrizitt in Form eines besonderen Raumzustandes, der als elektrisches Feld bezeichnet wird. Normalerweise erscheint ein Stoff nach auen hin elektrisch neutral, weil ebenso viele positive wie negative Ladungen in ihm enthalten sind.

  3. Astronomical discoveries and the renown of a late humanistic scholar - Marx Welser's role in the discussion on sunspots between Scheiner, Galilei and Kepler. (German Title: Astronomische Entdeckungen und das Renommee eies spthumanistischen Gelehrten - Marx Welsers Rolle in der Sonnenfleckendiskussion zwischen Scheiner, Galilei und Kepler)

    NASA Astrophysics Data System (ADS)

    Ferber, Magnus Ulrich

    The example of the late humanistic scholar Max Welser (1558-1614) from Augsburg proves the gain of recognition of astronomy in the scholarly surroundings, which arose through its new results after the invention of the telescope. This explains why an exponent of the humanistic ideal of education worked towards appearing as the patron of a professional astronomical debate, as it was done by Welser, in 1611-1613, in the debate on sunspots between Christoph Scheiner and Galileo Galilei. Nevertheless, the split in the scholarly world between humanists and scientists proved to be so fundamental at that time, that Welser, in order to be accepted also by the mathematici, had to establish anew his renown in these circles independent of his philological achievements. At the same time, he did not undertake anything to integrate the astronomers into the humanistic res publica litteraria.

  4. Hilft es die Regel zu wissen um sie anzuwenden? Das Verhaltnis von Melatlinguistischem Bewusstsein und grammatischer Kompetenz (Is Knowledge of Grammar Rules Helpful in Their Application? The Relationship between Metalinguistic Insight and Grammar Competency in the Study of German as a Foreign Language).

    ERIC Educational Resources Information Center

    Schultz, Renate A.

    2002-01-01

    Examines to what extent, if at all, grammar instruction fosters or accelerates language acquisition. Presents a study investigating the acquisition of syntactic or morphological structures in 340 students learning German as a foreign language. The results are discussed. (AS)

  5. Low-Amplitude Anisotropic Wave Train Events during Passage of Interplanetary Magnetic Clouds / Mazas Amplit?das Anizotropiju Vi??u Par?d?bu Sec?ba Starpplan?tu Magn?tisko M?ko?u Raan?s Laik?

    NASA Astrophysics Data System (ADS)

    Agarwal, R.; Mishra, R. K.

    2013-04-01

    The work presents a continuation in the series related to the long-term space observations made by ground-based neutron monitoring stations. The cosmic ray intensity variation is considered as affected by interplanetary magnetic clouds during low-amplitude anisotropic wave train (LAAWT) events. It was observed that the solar wind velocity is higher than normal (> 300 km/s) while the interplanetary magnetic field (IMF) strength is lower than normal on the arrival of magnetic cloud during LAAWT events. The proton density is found to remain significantly low at high solar-wind velocity, which was expected. The north/south component of interplanetary magnetic field turns southward one day before the arrival of cloud and remains in this direction after that. The cosmic ray intensity is found to increase with the solar wind velocity. It is noteworthy that the cosmic ray intensity significantly increases before and 90 h after the arrival of such a cloud, and decreases gradually after its passage. The north/south component of IMF (Bz) is found to significantly correlate with latitude angle (?) and disturbance storm time index Dst, whereas the geomagnetic activity index (Ap) significantly anti-correlates with these parameters, decreasing with (?) and Dst increasing on the arrival of interplanetary magnetic cloud during LAAWT events. Raksts ir turpin?jums darbu s?rijai par da?d?m par?d?b?m kosmos?, kas balst?tas uz nov?rojumiem un datiem, ieg?tiem da?dos laika periodos pasaules neitronu monitoringa stacij?s (Deep River, Tokija, Maskava, u.c.). Rakst? apskat?t?s kosmisko staru intensit?tes izmai?as tiek pamatotas ar starpplan?tu magn?tisko m?ko?u par?d?anos. Tiek par?d?tas saules v?ja, magn?tisk? lauka sp?ka, v?tru pertub?ciju indeksa un citu parametru atkar?ba no magn?tisko m?ko?u par?d?an?s. Tiek atz?m?ts, ka kosmisko staru intensit?te strauji pieaug pirms m?ko?u par?d?an?s un 90 stundu laik? p?c tiem, un pak?peniski samazin?s p?c to aizieanas.

  6. Patrik and Putrik and Clown Ferdl; Findings and Cognition on the Television Perception of Children and Young People Based on the Prize-Winning Programmes of Prix Jeunesse 1966. Publications of the Internationales Zentralinstitut fur das Jugend- und Bildungsfernsehen, Number 3.

    ERIC Educational Resources Information Center

    Griebel, Francine, Ed.; Burger, Anette, Ed.

    The results of an investigation of the reactions of young children (ranging from four to nine years of age) in France, Germany, England, America, and Czechoslovkia to two Prix Jeunesse winning television films are examined in this document. Summarized reports from each of the participating countries for the film "Patrik and Putrik" and,…

  7. Disciplines and Professors of Astronomy in Undergraduate Physics Teachers Formation Courses in Brazilian Universities. (Spanish Title: Disciplinas y Profesores de Astronomia en los Cursos de Licenciatura en Física en Las Universidades Brasileñas.) Disciplinas e Professores de Astronomia Nos Cursos de Licenciatura em Física das Universidades Brasileiras

    NASA Astrophysics Data System (ADS)

    Roberto, Artur Justiniano, Jr.; Reis, Thiago Henrique; dos Reis Germinaro, Daniel

    2014-12-01

    This article is the result of a research on basic training in Astronomy in physics degrees that performed the ENADE 2011 national examination. The objective was to identify whether there are disciplines of Astronomy in these courses, whether are mandatory or optional, its workload and when it is offered. The relationship between astronomers, physics degrees and disciplines of Astronomy was investigated. To perform this research we examined the results of ENADE 2011 and also the census of Brazilian Astronomical Society. As a result it is observed that in only 15% of the courses there is a mandatory subject of Astronomy, and therefore there is a high probability that 85% of physics teachers trained in 2011 have not had any discipline of Astronomy during their graduation. In addition, the data collected in this study shows a low number of members of SAB (Sociedade Astronômica Brasileira) among the surveyed courses. We have verified that the presence of astronomers in a given university does not imply to have a mandatory discipline of Astronomy in physics degrees at the same university. Este artículo es el resultado de una investigación sobre la formación básica en Astronomía en los cursos de Profesorado en Física que hicieron el examen nacional ENADE 2011. El objetivo del trabajo fue identificar se existen disciplinas de Astronomía en estos cursos, si son obligatorias u optativas, cuál es su carga horaria y el semestre en que son ofrecidas. Se investigó también la correlación entre astrónomos, los cursos de licenciatura en Física y las disciplinas de Astronomía. Para realizar esta investigación se utilizaron los datos del ENADE 2011 y también del censo de la Astronomía brasileña. Como resultado, se observó que en solo 15% de los cursos existe una disciplina obligatoria de Astronomía y que existe una grande probabilidad de que 85% de los profesores de Física formados en el año de 2011 no hayan cursado ninguna disciplina de Astronomía durante su formación. Aparte de eso, los datos levantados en este trabajo apuntan para un número bajo de afiliados a la SAB (Sociedade Astronômica Brasileira) en los cursos investigados. Se verificó que tener astrónomos en una institución no implica tener una disciplina obligatoria de Astronomía en el curso de licenciatura en Física. Este artigo é o resultado de uma pesquisa sobre a formação básica em Astronomia nos cursos de Licenciatura em Física que fizeram o exame nacional ENADE 2011. O objetivo do trabalho foi identificar se há disciplinas de Astronomia nesses cursos, se ela é obrigatória ou optativa/eletiva, qual a sua carga horária e o período em que é oferecida. Pesquisou-se também a relação entre astrônomos, cursos de Licenciatura em Física e disciplinas de Astronomia. Para realizar essa pesquisa utilizamos os dados do ENADE 2011 e também do censo da Astronomia brasileira. Como resultado, se observa que em apenas 15% dos cursos existe uma disciplina obrigatória de Astronomia e que há uma grande probabilidade de que 85% dos professores de Física formados em 2011 não cursaram nenhuma disciplina de Astronomia durante a graduação. Além disso, os dados levantados nesse trabalho apontam um baixo número de filiados à SAB nos cursos pesquisados. Identifica-se que ter astrônomos na instituição não implica em disciplina obrigatória de Astronomia no curso de Licenciatura em Física.

  8. A relationship between tolerance to dehydration of rice cell lines and ability for ABA synthesis under stress.

    PubMed

    Perales, Lorena; Arbona, Vicent; Gmez-Cadenas, Aurelio; Cornejo, Maria-Jesus; Sanz, Amparo

    2005-08-01

    Plant dehydration is commonly caused by some adverse environmental conditions such as salinity, drought and freezing. As the plant hormone abscisic acid (ABA) is involved in responses to water stress, we studied its putative relationship with the degree of tolerance to these abiotic stresses. For this purpose we used cell lines that had been established from mature embryos of rice (Oryza sativa L, cvs. Bahia and Bomba), and selected by their high (L-T) or low (L-S) levels of tolerance to each type of stress. Tolerance of rice calli to either osmotic, saline, or freezing stress was generally improved by a previous treatment with ABA. This ABA effect was evident in those callus lines with low tolerance (L-S), as their ability to recover from stress increased up to three fold. Independent of the cultivar used, there were no significant differences in the endogenous ABA contents between untreated L-T and L-S lines. However, upon stress, the increase in endogenous ABA was higher in L-T than in L-S lines. These results, together with those obtained by using Fluridone, an inhibitor of ABA synthesis, show that differences in the level of cell tolerance to osmotic, saline and freezing stress are related to their different capacity of ABA synthesis under stress conditions. PMID:16198586

  9. Unraveling the in vitro and in vivo metabolism of diacetoxyscirpenol in various animal species and human using ultrahigh-performance liquid chromatography-quadrupole/time-of-flight hybrid mass spectrometry.

    PubMed

    Yang, Shupeng; De Boevre, Marthe; Zhang, Huiyan; De Ruyck, Karl; Sun, Feifei; Wang, Zhanhui; Cao, Xingyuan; Shen, Jianzhong; De Saeger, Sarah; Zhang, Suxia

    2015-11-01

    Diacetoxyscirpenol (DAS), a Fusarium mycotoxin belonging to the trichothecene type A mycotoxins, is able to contaminate food and feed worldwide. Only limited information is available regarding the metabolism of DAS. The present study used ultrahigh-performance liquid chromatography-quadrupole/time-of-flight hybrid mass spectrometry (UHPLC-Q/TOF) to investigate the in vitro phase I and II metabolism of DAS by rat, chicken, swine, goat, cow, and human liver microsomes. An extensive metabolization profile of DAS has been observed. A total of seven phase I and three phase II metabolites of DAS were detected. Among the identified molecules, four phase I metabolites (8?-hydroxy-DAS, neosolaniol, 7-hydroxy-DAS, and its epimer) and two phase II metabolites (4-deacetyl-DAS-3-glucuronic acid and 4-deacetyl-DAS-4-glucuronic acid) were identified for the first time. These results indicate that the major metabolic pathways of DAS in vitro were hydrolyzation (M1-M3), hydroxylation (M4-M7), and conjugation (M8-M10). Qualitative differences in phase I and II metabolic profiles of DAS between the five animal species and human were observed. 4-Deacetyl-DAS was the primary metabolite from liver microsomes of all species, especially human. The in vivo metabolism of DAS in rats and chickens after oral administration of DAS was also investigated and compared. The major metabolites for rats and chickens were 4-deacetyl-DAS and 7-hydroxy-DAS. These results will help to gain a more detailed insight into the metabolism and toxicity of DAS among different animal species and human. Graphical Abstract The metabolism of diacetoxyscirpenol in farm animals and human. PMID:26362158

  10. Beginn des Studiums

    NASA Astrophysics Data System (ADS)

    Domnick, Ivonne

    Ihr Herz schlgt fr die Naturwissenschaften? Die Arbeitsmarktaussichten sind gut. Das Studium einer der vier MINT-Disziplinen ist daher eine gute Investition in die Zukunft. Wie Sie erfolgreich in das Studium starten, erfahren Sie auf den folgenden Seiten.

  11. Europäisches Organ der Festkörperforschung und DDR-Devisenbringer Die Zeitschrift Physica Status Solidi im Kalten Krieg

    NASA Astrophysics Data System (ADS)

    Hoffmann, Dieter

    Mit dem Ziele, ein einheitliches internationales Organ der Festkrperphysik fr den europischen Raum zu schaffen, das eine rasche Publikation der fr das Festkrpergebiet reprsentative Arbeiten ermglicht, wird durch ein internationales Herausgebergremium eine neue wissenschaftliche Zeitschrift gegrndet.

  12. 48 CFR 309.403 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Acquisition Policy and Accountability (DAS/GAPA). Initiating official means the Contracting Officer, the HCA, the Associate DAS for Acquisition, or the Inspector General (IG). Suspending official means the...

  13. 76 FR 61060 - Fisheries of the Northeastern United States; Northeast Multispecies Fishery; Correction to Cod...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-03

    ... limit to 500 lb (226.8 kg) per DAS from 800 lb (362.9 kg) per DAS (76 FR 23042; April 25, 2011). An... 2,000 lb (907.2 kg) per DAS (76 FR 30035; May 24, 2011). A second inseason adjustment, on August 30... (136.1 kg) per DAS (76 FR 53832, August 30, 2011). Due to an oversight, the HB trip limits for GOM...

  14. 77 FR 59132 - Fisheries of the Northeastern United States; Northeast Multispecies Fishery; Fishing Year 2012...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-26

    .... ACTION: Temporary rule. SUMMARY: NMFS adjusts the differential days-at-sea (DAS) rate for common pool... Specialist, (978) 675-2153. SUPPLEMENTARY INFORMATION: FY 2012 Differential DAS Counting for Common Pool... common pool vessels in the distinct Differential DAS Area where each stock is predominantly caught....

  15. Development and Validation of the Dysfunctional Attitude Scale: A Preliminary Investigation.

    ERIC Educational Resources Information Center

    Weissman, Arlene N.; Beck, Aaron T.

    The Dysfunctional Attitude Scale (DAS) was developed to measure pervasive negative attitudes of a depressed person towards self, outside world, and future. The DAS follows Beck's construct of cognitive dysfunction. Two studies investigated the psychometric properties of the DAS and the relationship between cognition and affect in 300 normal

  16. 14 CFR 21.441 - Procedure manual.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... manual. (a) No DAS may exercise any authority under this subpart unless it submits, and obtains approval... limitations or Aircraft Flight Manuals, and sign supplemental type certificates. (b) No DAS may continue to perform any DAS function affected by any change in facilities or staff necessary to continue to meet...

  17. 48 CFR 333.104 - Protests to GAO.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Associate DAS for Acquisition through OGC-GLD). Should OGC-GLD concur, it shall forward the request to the Associate DAS for Acquisition for final approval. The written request for approval shall contain all... Associate DAS for Acquisition. (2) If the request to make an award notwithstanding the protest is...

  18. Efficiently Assessing Negative Cognition in Depression: An Item Response Theory Analysis of the Dysfunctional Attitude Scale

    ERIC Educational Resources Information Center

    Beevers, Christopher G.; Strong, David R.; Meyer, Bjorn; Pilkonis, Paul A.; Miller, Ivan R.

    2007-01-01

    Despite a central role for dysfunctional attitudes in cognitive theories of depression and the widespread use of the Dysfunctional Attitude Scale, form A (DAS-A; A. Weissman, 1979), the psychometric development of the DAS-A has been relatively limited. The authors used nonparametric item response theory methods to examine the DAS-A items and

  19. 77 FR 61378 - Submission for OMB Review; Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-09

    ... multispecies DAS leasing requirements at Sec. 648.82(k) form the basis for this collection of information. The NE Multispecies Days-at-Sea (DAS) Leasing Program was implemented in 2004 as a result of Amendment 13 (69 FR 22906) which substantially reduced the number of DAS available for the NE multispecies...

  20. 14 CFR 21.463 - Supplemental type certificates.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... this subpart, the DAS shall follow the procedure manual prescribed in 21.441 and shall, before... change; (ii) The airworthiness requirements of this chapter (by part and effective date) that the DAS... STC, the DAS shall submit to the Administrator (1) Two copies of the STC; (2) One copy of the...

  1. 48 CFR 305.202 - Exceptions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... acquisition channels, including the HCA, to Associate DAS for Acquisition requesting an exception to synopsizing. The Associate DAS for Acquisition shall review the request and decide whether an exception is appropriate and reasonable. If it is, the Associate DAS for Acquisition shall take the necessary...

  2. Photoinduced electron transfer reaction in diaminostilbene-tethered DNA duplexes.

    PubMed

    Ito, Takeo; Hayashi, Aiko; Uchida, Tsukasa; Tanabe, Kazuhito; Yamada, Hisatsugu; Nishimoto, Sei-Ichi

    2009-01-01

    DNA duplexes containing diaminostilbene (DAS) as a photoinduced electron donor were synthesized to investigate mechanisms of electron injection into DNA and the succeeding electron transfer in the duplexes. DAS-Capped hairpin DNA showed a high structural stability thereby attains large interaction between DAS and the terminal base pair. DAS-Tethered DNA by a single linker at the end of the duplex was also synthesized and the yields of photoinduced electron transfer through mismatched base pairs were quantified. Both duplexes showed similar electron transfer efficiencies depending on the base pairs, which suggests DAS stacks well on the "pi-way" of the duplex DNA. PMID:19749330

  3. Integrating protein annotation resources through the Distributed Annotation System.

    PubMed

    Olason, Pll Islfur

    2005-07-01

    Using the Distributed Annotation System (DAS) we have created a protein annotation resource available at our web page: http://www.cbs.dtu.dk, as a part of the BioSapiens Network of Excellence EU FP6 project. The DAS protocol allows us to gather layers of annotation data for a given sequence and thereby gain an overview of the sequence's features. A user-friendly graphical client has also been developed (http://www.cbs.dtu.dk/cgi-bin/das), which demonstrates the possibility of integrating DAS annotation data from multiple sources into a simple graphical view. The client displays protein feature annotations from the Center for Biological Sequence Analysis as well as from the BioSapiens reference UniProt server (http://www.ebi.ac.uk/das-srv/uniprot/das) at the European Bioinformatics Institute. Other DAS data sources for protein annotation will be added as they become available. PMID:15980514

  4. Is ABA involved in tolerance responses to salinity by affecting cytoplasm ion homeostasis in rice cell lines?

    PubMed

    Pons, Ral; Cornejo, Mara Jess; Sanz, Amparo

    2013-01-01

    The ability of plant cells to maintain cytoplasm ion homeostasis under saline stress is among the main mechanisms involved in salt tolerance. To cope with excess Na(+), cells extrude it from the cytoplasm, which requires expenditure of metabolic energy, provided by H(+) gradients generated by membrane-bound H(+)-pumps. ABA is well-known to be involved in physiological processes elicited or enhanced by stresses causing cell dehydration. In this work we studied the possible implication of this plant hormone in the control of salt-induced cellular mechanisms conducting to Na(+) extrusion from the cytoplasm. We used rice (Oryza sativa L.) cell lines selected for their different tolerance to salinity to measure the response to ABA of H(+)-pumps and Na(+)/H(+)-antiporters associated to the plasma membrane and the tonoplast. Our results show that ABA generally enhances H(+)-pumping under salt stress but not under control conditions. This effect occurs to a higher extent across the tonoplast in the more tolerant lines (L-T). Na(+)/H(+) antiport activity is practically undetectable in calli under control conditions, pre-treated or not with ABA, but shows a strong activation under salinity across the tonoplast, particularly in L-T lines (cv Bahia) and also across de plasma membrane in cv Bomba. In these lines, prior treatments with ABA tend to reduce the NaCl enhanced activity of both antiporters. Overall, under saline conditions ABA seems to affect synergistically H(+) pumping and antagonistically Na(+) extrusion. A complex network of positive and negative regulatory signals seems involved in restoring ion cell homeostasis under salt stress. PMID:23202047

  5. Transcriptional activation of the herpes simplex virus type 1 UL38 promoter conferred by the cis-acting downstream activation sequence is mediated by a cellular transcription factor.

    PubMed Central

    Guzowski, J F; Singh, J; Wagner, E K

    1994-01-01

    The herpes simplex virus (HSV) type 1 strict late (gamma) UL38 promoter contains three cis-acting transcriptional elements: a TATA box, a specific initiator element, and the downstream activation sequence (DAS). DAS is located between positions +20 and +33 within the 5' untranslated leader region and strongly influences transcript levels during productive infection. In this communication, we further characterize DAS and investigate its mechanism of action. DAS function has a strict spacing requirement, and DAS contains an essential 6-bp core element. A similarly positioned element from the gamma gC gene (UL44) has partial DAS function within the UL38 promoter context, and the promoter controlling expression of the gamma US11 transcript contains an identically located element with functional and sequence similarity to UL38 DAS. These data suggest that downstream elements are a common feature of many HSV gamma promoters. Results with recombinant viruses containing modifications of the TATA box or initiator element of the UL38 promoter suggest that DAS functions to increase transcription initiation and not the efficiency of transcription elongation. In vitro transcription assays using uninfected HeLa nuclear extracts show that, as in productive infection with recombinant viruses, the deletion of DAS from the UL38 promoter dramatically decreases RNA expression. Finally, electrophoretic mobility shift assays and UV cross-linking experiments show that DAS DNA forms a specific, stable complex with a cellular protein (the DAS-binding factor) of approximately 35 kDa. These data strongly suggest that the interaction of cellular DAS-binding factor with DAS is required for efficient expression of UL38 and other HSV late genes. Images PMID:7966567

  6. Einleitung

    NASA Astrophysics Data System (ADS)

    Winner, Hermann; Hakuli, Stephan; Wolf, Gabriele

    Das Thema Fahrerassistenzsysteme ist bei Automobilherstellern, Zulieferern und in der universitren Forschung seit geraumer Zeit aktuell und hat in den vergangenen Jahren auch das Interesse der ffentlichkeit geweckt. Die Zahl der am Markt verfgbaren Systeme und ihr Funktionsumfang zur Untersttzung des Fahrers bei der Ausfhrung der Fahraufgabe nehmen stetig zu. Bedingt durch die jngsten Entwicklungen wird der Begriff Fahrerassistenzsysteme (in unserer abgekrzten Welt kurz mit FAS bezeichnet) heute zumeist mit Systemen der Aktiven Sicherheit, d. h. Systemen, die das Eintreten eines Unfalls verhindern, in Verbindung gebracht. Tatschlich kann dieser Begriff jedoch sehr viel breiter gefasst werden, denn schon mit der Erfindung des elektrischen Starters, der die manuelle Kurbel ablste, war ein erstes Fahrerassistenzsystem geboren, das das Fahren erleichterte. Auch Dinge wie die automatische Blinkerhebelrckstellung oder das synchronisierte Handschaltgetriebe werden heute als Selbstverstndlichkeiten angesehen, sind im eigentlichen Sinne jedoch als Fahrerassistenzsysteme zu verstehen.

  7. In vitro efficacy of diallyl sulfides against the periodontopathogen Aggregatibacter actinomycetemcomitans.

    PubMed

    Velliyagounder, Kabilan; Ganeshnarayan, Krishnaraj; Velusamy, Senthil Kumar; Fine, Daniel H

    2012-05-01

    The in vitro antibacterial effects of diallyl sulfide (DAS) against the Gram-negative periodontopathogen Aggregatibacter actinomycetemcomitans, the key etiologic agent of the severe form of localized aggressive periodontitis and other nonoral infections, were studied. A. actinomycetemcomitans was treated with garlic extract, allicin, or DAS, and the anti-A. actinomycetemcomitans effects of the treatment were evaluated. Garlic extract, allicin, and DAS significantly inhibited the growth of A. actinomycetemcomitans (greater than 3 log; P < 0.01) compared to control cells. Heat inactivation of the garlic extracts significantly reduced the protein concentration; however, the antimicrobial effect was retained. Purified proteins from garlic extract did not exhibit antimicrobial activity. Allicin lost all its antimicrobial effect when it was subjected to heat treatment, whereas DAS demonstrated an antimicrobial effect similar to that of the garlic extract, suggesting that the antimicrobial activity of garlic extract is mainly due to DAS. An A. actinomycetemcomitans biofilm-killing assay performed with DAS showed a significant reduction in biofilm cell numbers, as evidenced by both confocal microscopy and culture. Scanning electron microscopy (SEM) analysis of DAS-treated A. actinomycetemcomitans biofilms showed alterations of colony architecture indicating severe stress. Flow cytometry analysis of OBA9 cells did not demonstrate apoptosis or cell cycle arrest at therapeutic concentrations of DAS (0.01 and 0.1 ?g/ml). DAS-treated A. actinomycetemcomitans cells demonstrated complete inhibition of glutathione (GSH) S-transferase (GST) activity. However, OBA9 cells, when exposed to DAS at similar concentrations, showed no significant differences in GST activity, suggesting that DAS-induced GST inhibition might be involved in A. actinomycetemcomitans cell death. These findings demonstrate that DAS exhibits significant antibacterial activity against A. actinomycetemcomitans and that this property might be utilized for exploring its therapeutic potential in treatment of A. actinomycetemcomitans-associated oral and nonoral infections. PMID:22330917

  8. Development and evaluation of a distribution automation system for an Indian utility

    SciTech Connect

    Krishna Rao, M.V.; Pandurangam, J.V.; Peri, R.; Clinard, K.N.; Radha Krishna, C.

    1995-01-01

    This paper describes a study conducted by the Andhra Pradesh State Electricity Board (APSEB), India, and ECC, Inc., USA for the design or a distribution automation system (DAS). Distribution automation functions applicable to an Indian utility were identified. Communications technologies that are capable of meeting DAS requirements were evaluated, and a communications system suitable for India was deemed. A benefit/cost analysis was performed; first for a basic DAS and then for additional distribution automation functions.

  9. Development and evaluation of a distribution automation system for an Indian utility

    SciTech Connect

    Rao, M.V.K.; Pandurangam, J.V.; Peri, R.; Clinard, K.N.; Krishna, C.R.

    1994-12-31

    This paper describes a study conducted by the Andhra Pradesh State Electricity Board (APSEB), India, and ECC, Inc., USA for the design of a distribution automation system (DAS). Distribution automation functions applicable to an Indian utility were identified. Communications technologies that are capable of meeting DAS requirements were evaluated, and a communications systems suitable for India was defined. A benefit/cost analysis was performed; first for a basic DAS and then for additional distribution automation functions.

  10. In Vitro Efficacy of Diallyl Sulfides against the Periodontopathogen Aggregatibacter actinomycetemcomitans

    PubMed Central

    Ganeshnarayan, Krishnaraj; Velusamy, Senthil Kumar; Fine, Daniel H.

    2012-01-01

    The in vitro antibacterial effects of diallyl sulfide (DAS) against the Gram-negative periodontopathogen Aggregatibacter actinomycetemcomitans, the key etiologic agent of the severe form of localized aggressive periodontitis and other nonoral infections, were studied. A. actinomycetemcomitans was treated with garlic extract, allicin, or DAS, and the anti-A. actinomycetemcomitans effects of the treatment were evaluated. Garlic extract, allicin, and DAS significantly inhibited the growth of A. actinomycetemcomitans (greater than 3 log; P < 0.01) compared to control cells. Heat inactivation of the garlic extracts significantly reduced the protein concentration; however, the antimicrobial effect was retained. Purified proteins from garlic extract did not exhibit antimicrobial activity. Allicin lost all its antimicrobial effect when it was subjected to heat treatment, whereas DAS demonstrated an antimicrobial effect similar to that of the garlic extract, suggesting that the antimicrobial activity of garlic extract is mainly due to DAS. An A. actinomycetemcomitans biofilm-killing assay performed with DAS showed a significant reduction in biofilm cell numbers, as evidenced by both confocal microscopy and culture. Scanning electron microscopy (SEM) analysis of DAS-treated A. actinomycetemcomitans biofilms showed alterations of colony architecture indicating severe stress. Flow cytometry analysis of OBA9 cells did not demonstrate apoptosis or cell cycle arrest at therapeutic concentrations of DAS (0.01 and 0.1 ?g/ml). DAS-treated A. actinomycetemcomitans cells demonstrated complete inhibition of glutathione (GSH) S-transferase (GST) activity. However, OBA9 cells, when exposed to DAS at similar concentrations, showed no significant differences in GST activity, suggesting that DAS-induced GST inhibition might be involved in A. actinomycetemcomitans cell death. These findings demonstrate that DAS exhibits significant antibacterial activity against A. actinomycetemcomitans and that this property might be utilized for exploring its therapeutic potential in treatment of A. actinomycetemcomitans-associated oral and nonoral infections. PMID:22330917

  11. Schnelles Voxel-Resampling fr DRR-Raycasting-Verfahren in der 2D/3D-Registrierung

    NASA Astrophysics Data System (ADS)

    Newe, Axel; Rascher-Friesenhausen, Richard; Peitgen, Heinz-Otto

    Das Raycasting ist ein etabliertes Verfahren zur Berechnung von Digital Rekonstruierten Rntgenbildern (DRRs), auf Basis von CT-Daten approximierten Radiographien, die vorwiegend fr die 2D/3D Registrierung und die Strahlentherapieplanung eingesetzt werden. Das Strahlresampling ist der mit Abstand langwierigste Schritt des Raycastings. Es wird ein Algorithmus vorgestellt, der diesen Vorgang auf das absolute Minimum reduziert, aber trotzdem die Berechnung von DRRs ermglicht, die qualitativ fr die meisten Anwendungen in der 2D/3D-Registrierung ausreichen.

  12. Higher twist distribution amplitudes of the pion and electromagnetic form factor F{sub {pi}}(Q{sup 2})

    SciTech Connect

    Agaev, S.S.

    2005-10-01

    The pion electromagnetic form factor is calculated within the QCD light-cone sum rule method and using a renormalon model for the higher twist distribution amplitudes (DAs). The theoretical predictions are compared with the experimental data and constraints on the pion leading and twist-4 DAs are extracted. An upper bound on the twist-4 contribution to the form factor and estimates of effects due to higher conformal spins in the pion twist-4 DAs are obtained.

  13. Data acquisition system time measurement capabilities using WorkBench{trademark} software

    SciTech Connect

    Coutts, D.A.

    1992-04-01

    There is an increasing interest in the ability to measure transient behavior in the Heat Transfer Laboratory (HTL). To accomplish this the timing system behavior for the Data Acquisition Systems (DAS) must be evaluated. This report discusses the evaluation of a DAS timing system using WorkBench{trademark} Software in a Macintosh II environment. It also describes a method which can be successfully used to calibrate the timing system associated with the DAS.

  14. Data acquisition system time measurement capabilities using WorkBench[trademark] software

    SciTech Connect

    Coutts, D.A.

    1992-04-01

    There is an increasing interest in the ability to measure transient behavior in the Heat Transfer Laboratory (HTL). To accomplish this the timing system behavior for the Data Acquisition Systems (DAS) must be evaluated. This report discusses the evaluation of a DAS timing system using WorkBench[trademark] Software in a Macintosh II environment. It also describes a method which can be successfully used to calibrate the timing system associated with the DAS.

  15. Finanzierung des Studiums

    NASA Astrophysics Data System (ADS)

    Domnick, Ivonne

    "Das liebe Geld - ein Thema, das Sie durch das ganze Studium begleitet und auch in der Examensphase und bei der spteren Berufswahl eine entscheidende Rolle spielen wird. Naturwissenschaftler und Ingenieure haben auf dem Arbeitsmarkt sicher derzeit die Nase vorn und brauchen sich ber ihre berufliche Zukunft nicht so groe Gedanken machen. Doch vor der Karriere muss zunchst einmal eine sichere Studienfinanzierung auf die Beine gestellt werden.

  16. Stress-oriented driver assistance system for electric vehicles.

    PubMed

    Athanasiou, Georgia; Tsotoulidis, Savvas; Mitronikas, Epaminondas; Lymberopoulos, Dimitrios

    2014-01-01

    Stress is physiological and physical reaction that appears in highly demanding situations and affects human's perception and reaction capability. Occurrence of stress events within highly dynamic road environment could lead to life-threatening situation. With the perspective of safety and comfort driving provision to anxious drivers, in this paper a stress-oriented Driver Assistance System (DAS) is proposed. The DAS deployed on Electric Vehicle. This novel DAS customizes driving command signal in respect to road context, when stress is detected. The effectiveness of this novel DAS is verified by simulation in MATLAB/SIMULINK environment. PMID:25571348

  17. Grundlagen der Dieseleinspritzung

    NASA Astrophysics Data System (ADS)

    Grieshaber, Hermann

    Die Verbrennungsvorgnge im Dieselmotor - und damit die Motorleistung, der Kraftstoffverbrauch, die Abgaszusammensetzung und das Verbrennungsgerusch - hngen in entscheidendem Mae von der Aufbereitung des Luft- Kraftstoff-Gemischs ab.

  18. Evaluation of reproductive function among men occupationally exposed to a stilbene derivative: I. Hormonal and physical status.

    PubMed

    Grajewski, B; Whelan, E A; Schnorr, T M; Mouradian, R; Alderfer, R; Wild, D K

    1996-01-01

    This is the first of two reports describing a National Institute for Occupational Safety and Health (NIOSH) Health Hazard Evaluation conducted in response to complaints of impotence and decreased libido among male employees who manufactured 4,4'-diaminostilbene-2,2' disulfonic acid (DAS; CAS 81-11-8), an intermediate in the manufacture of fluorescent whitening agents. DAS is structurally similar to the synthetic estrogen diethylstilbestrol (DES). Levels of six reproductive hormones in 30 male workers who manufactured DAS (current DAS workers) and 20 former DAS workers were compared to levels of 35 workers who manufactured plastics additives. Current and former DAS workers had lower mean total testosterone (TT) levels compared to additives workers (458 and 442, respectively, vs. 556 ng/dL; p = 0.05 and 0.04). Current and former DAS workers were 3.6 (95% CI, 0.5-24.4) and 2.2 (95% CI, 0.3-18.0) times more likely than additives workers to have lowest quartile TT levels (< 386 ng/dL) after adjustment for age and body mass index. Duration of employment in DAS production was negatively related to the workers' testosterone levels. These data suggest that occupational DAS exposure may be associated with alterations in male reproductive hormone levels. PMID:8808042

  19. Dietary aluminosilicate supplement enhances immune activity in mice and reinforces clearance of porcine circovirus type 2 in experimentally infected pigs.

    PubMed

    Jung, Bock-Gie; Toan, Nguyen Tat; Cho, Sun-Ju; Ko, Jae-hyung; Jung, Yeon-Kwon; Lee, Bong-Joo

    2010-07-14

    Aluminosilicate is the major component of clay minerals such as zeolite, bentonite and clinoptilolite. The minerals possess a number of beneficial activities, especially in regulating the immune system. The aims of the present study were to evaluate immune enhancing effects of dietary aluminosilicate supplement (DAS) in mice, and to demonstrate clearance effects of DAS against porcine circovirus type 2 (PCV2) in experimentally infected pigs as an initial step towards the development of an antibiotic substitute for use in pigs. Relative messenger RNA expression levels of interferon-gamma, interleukin-4 and tumor necrosis factor-alpha, phagocytic activities of polymorphonuclear leucocytes, serum antibody production level and spleen B cell ratio were significantly increased in the DAS groups of mice compared with the control group (each feeding group had three replications with 5 mice each). The results indicated that general immune activity including cellular and humoral immunity could be enhanced by DAS in mice. In experimentally PCV2-infected pigs, the load of viral genome in nasal swab, serum and lung of the DAS group of pigs was significantly decreased compared with the control group at 28 days post-infection (each group three pigs). Corresponding histopathological analyses demonstrated that pigs in the DAS group displayed mild and less severe abnormal changes compared with the control group, indicating that DAS reinforces clearance of PCV2 in experimentally infected pigs. This may relate to general immune enhancing effects of DAS in mice. Therefore DAS will help the health of animal, especially in swine. PMID:20022715

  20. Diallyl sulfide promotes cell-cycle arrest through the p53 expression and triggers induction of apoptosis via caspase- and mitochondria-dependent signaling pathways in human cervical cancer Ca Ski cells.

    PubMed

    Chiu, Tsan-Hung; Lan, Kai-Ying; Yang, Mei-Due; Lin, Jen-Jyh; Hsia, Te-Chun; Wu, Chin-Tung; Yang, Jai-Sing; Chueh, Fu-Shin; Chung, Jing-Gung

    2013-01-01

    Diallyl sulfide (DAS) is a component of garlic (Alliaceae family). Although diallyl polysulfide has been shown to exhibit anticancer activities, no report explored DAS-affected cell death in human cervical cancer cells in vitro. This study investigated DAS affected on cell-cycle regulation and apoptosis in human cervical cancer Ca Ski cells. DAS at 25-100 ?M decreased the viability of Ca Ski cells by increasing G0/G1 phase arrest followed by induction of apoptosis in concentration- and time-dependent effects. Flow cytomteric assay indicated that DAS (75 ?M) promoted the production of Ca(2+) accumulation and decreased the level of mitochondrial membrane potential in Ca Ski cells. Western blotting showed that 75 ?M of DAS-induced G0/G1 phase arrest was mediated through the increased expression of p21, p27, and p53 with a simultaneous decrease in CDK2, CDK6, and CHK2 expression. The characteristics of apoptosis, such as morphological changes and DNA condensation, altered the ratio of Bax/Bcl-2 and sub-G1 phase occurred in Ca Ski cells after exposure to DAS. Furthermore, DAS induced mitochondrial dysfunction, leading to the release of cytochrome c for causing apoptosis in Ca Ski cells. These findings suggest that DAS might be a potential chemotherapeutic agent for the treatment of cervical cancer. PMID:23530650

  1. Kosmologie

    NASA Astrophysics Data System (ADS)

    Brner, Gerhard

    Grundriss: Das expandierende Universum (Galaxien, Modellvorstellungen, Ein Zeitrafferbild). Die Ausdehnung des Weltalls (Das Hubble'sche Gesetz, Bestimmung der Hubble-Konstanten durch Cepheidenmessungen, Bestimmung der Hubble-Konstanten durch SNIa). Das Alter der Sterne (Kugelsternhaufen, Entwicklung der Sterne: Das Hertzsprung-Russell-Diagramm, Die Altersbestimmung). Die Wrmestrahlung des Universums, Die Kosmologischen Modelle (Mathematische Vereinfachungen, Der gekrmmte Raum, Rotverschiebung und zeitliche Entwicklung). Leuchtende und dunkle Kosmische Materie (Die leuchtende Materie, Dunkle Materie in Galaxien, Dunkle Materie in Galaxienhaufen, Die baryonische Materie, Nichtbaryonische dunkle Materie). Die kosmische Hintergrundstrahlung - CMB (Akustische Schwingungen im frhen Universum, Beobachtungen und kosmische Parameter, Dunkle Materie und dunkle Energie). Die Entstehung der Strukturen im Universum (Einige theoretische berlegungen, Beobachtungen, Dunkle Halos und leuchtende Galaxien, Sterne und Elemente). Elementarteilchenphysik und Kosmologie (Die fundamentalen Krfte, Baryonasymmetrie). Das Inflationre Universum (Schwierigkeiten des Standardmodells, Das Inflationsmodell, Lsung der kosmologischen Rtsel, Chaotische Inflation, Kritische Anmerkungen). Weltentstehung (Die Mglichkeiten der Physik, Das anthropische Prinzip, Die Auswahl des Anfangszustands, Hawkings Vorschlag). Das Ende? Vertiefungen: Einheiten, Entfernungen, Elementarteilchen, Kosmologische Modelle, Allgemeine Relativittstheorie, Die Gravitation, Masse und Energie, Schwarze Lcher und Raumzeitsingularitt, Gleichgewicht, Das Vakuum.

  2. Elektrische Phnomene des Krpers und ihre Detektion

    NASA Astrophysics Data System (ADS)

    Bolz, Armin; Kikillus, Nicole; Moor, Claudius

    Im menschlichen Krper verfgen sowohl Nerven- als auch Muskelzellen ber die Eigenschaft, intra- und extrazellulre Ionenkonzentrationen zu verschieben und damit die Potenzialverteilung in ihrer Umgebung zu beeinflussen. ber unterschiedliche Synchronisationsverfahren sind makroskopische Zellverbnde zustzlich in der Lage, koordiniert ihre Felder zu verndern und somit auch signifikante, an der Krperoberflche messbare elektrische Signale zu erzeugen. Das vorliegende Kapitel beschreibt zunchst die elektrophysiologischen Grundlagen elektrischer Signale des menschlichen Krpers, die Synchronisationsmechanismen und die daraus entstehenden Felder, insbesondere das Elektrokardiogramm (EKG), das Elektroenzephalogramm (EEG) sowie das Elektromyogramm (EMG). Im Anschluss daran werden die wesentlichen Grundlagen der Messtechnik zur Erfassung bioelektrischer Phnomene erlutert. Einige Beispielapplikationen runden diesen Beitrag ab.

  3. Jenseits von Halley

    NASA Astrophysics Data System (ADS)

    Calder, Nigel; Lst, R.; Fischer, D.

    GIOTTO, das spektakulrste Raumprojekt seit der Mondlandung und ein Glanzstck der europischen Raumforschung, wird von dem versierten Autor Nigel Calder spannend dargestellt. GIOTTO hat sich bis auf 600 km dem Kometen Halley genhert, wurde dabei beschdigt, von der Erde aus repariert und hat danach noch den Kometen Grigg-Skjellerup besucht. Das Buch fhrt den Leser durch alle Fehlschlge und die glanzvollen Erfolge dieser internationalen Zusammenarbeit unter der Leitung der ESA. Der Autor geht auch auf das ROSETTA-Projekt ein, das derzeit in Vorbereitung ist. Der bersetzer hat in Zusammenarbeit mit dem Autor und den wissenschaftlichen Projektleitern bei der ESA den Text fr die deutsche Ausgabe aktualisiert und ergnzt.

  4. Dimensionality of the Chinese Dyadic Adjustment Scale Based on Confirmatory Factor Analyses

    ERIC Educational Resources Information Center

    Shek, Daniel T. L.; Cheung, C. K.

    2008-01-01

    Based on the responses of 1,501 Chinese married adults to the Chinese version of the Dyadic Adjustment Scale (C-DAS), confirmatory factor analyses showed that four factors were abstracted from the C-DAS (Dyadic Consensus, Dyadic Cohesion, Dyadic Satisfaction and Affectional Expression) and these four primary factors were subsumed under a

  5. 78 FR 13307 - Dow AgroSciences LLC; Availability of Petition for Determination of Nonregulated Status of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-27

    ...We are advising the public that the Animal and Plant Health Inspection Service (APHIS) has received a petition from Dow AgroSciences LLC (DAS) seeking a determination of nonregulated status of soybean designated as DAS-81419-2, which has been genetically engineered for resistance to certain lepidopteran pests. The petition has been submitted in accordance with our regulations concerning the......

  6. Concurrent Validity of the Early Screening Profiles and the Differential Ability Scales with an At-Risk Preschool Sample.

    ERIC Educational Resources Information Center

    McIntosh, David E.; Gibney, Laura; Quinn, Kevin; Kundert, Deborah

    2000-01-01

    Study looked at the relationship between the Early Screening Profiles (ESP) and the Differential Ability Scales (DAS). Participants were at risk pre-schoolers (N=94) from various ethnic backgrounds. A strong relationship was found between the ESP Total Screening and DAS General Conceptual Ability scores, indicating that the ESP is a good predictor

  7. Quantenphysik und Gravitation quivalenzprinzip gilt auch fr Quantenobjekte

    NASA Astrophysics Data System (ADS)

    Fray, Sebastian; Hnsch, Theodor W.; Weitz, Martin

    2005-03-01

    Gravitationstheorie und die Quantentheorie zu einer gemeinsamen Theorie vereinheitlichen, das ist eines der ungelsten Probleme der modernen Physik. Garchinger und Tbinger Wissenschaftler haben nun das quivalenzprinzip, einen Eckstein der Gravitationstheorie, mit der Methode der Atominterferometrie, die sich der quantenmechanischen Natur von Atomen bedient, berprft.

  8. N-succinyl chitosan–dialdehyde starch hybrid hydrogels for biomedical applications

    PubMed Central

    Kamoun, Elbadawy A.

    2015-01-01

    A new class of injectable, biocompatible and biodegradable hydrogel is reported. This hydrogel is derived from N-succinyl chitosan (SCS) mixed with water-soluble dialdehyde starch (DAS) without using a conventional chemical crosslinker. The hybrid hydrogel is formed owing to the Schiff’s base reaction between amine groups of SCS and dialdehyde groups of DAS to form —CH 000000000000 000000000000 000000000000 111111111111 000000000000 111111111111 000000000000 000000000000 000000000000 N— group. SCS, DAS, and SCS–DAS hybrid hydrogels were synthesized and then characterized by FTIR analysis spectroscopy. The influence of SCS:DAS ratio in hybrid polymers solution on physicochemical properties of resultant hydrogels (e.g. gelation time, gel fraction (%) and equilibrium swelling ratio), surface morphology, in vitro weight loss (%), and mechanical stability was examined. The results demonstrated that SCS content has a profound role for forming tighter crosslinked hybrid hydrogels, where the increase of SCS content reduces the time for hydrogel forming. Also, the water uptake and hydrolytic weight loss decrease. Meanwhile, the DAS content increases, and mechanical properties of SCS–DAS hybrid hydrogels decrease. Curcumin release profile and adhered HGF cells on hydrogel surface sharply influenced the SCS portion in hybrid hydrogel composition. The SCS–DAS hybrid hydrogel properties afforded a possible opportunity to be used as a covalent in situ forming hybrid hydrogels in biomedical applications such as, tissue engineering and cartilage repair. PMID:26843972

  9. Factorial Invariance of the Dyadic Adjustment Scale across Gender

    ERIC Educational Resources Information Center

    South, Susan C.; Krueger, Robert F.; Iacono, William G.

    2009-01-01

    The Dyadic Adjustment Scale (DAS; G. B. Spanier, 1976) is the most widely used inventory of relationship satisfaction in the social sciences, yet the question of whether it is measuring the same concept in men and women has never been addressed. In the current study, the authors examined the factor structure of the DAS in a sample of 900 currently

  10. Hren - Psychoakustik - Audiologie

    NASA Astrophysics Data System (ADS)

    Ellermeier, Wolfgang; Hellbrck, Jrgen

    Anatomisch ist das Ohr des Menschen in ueres Ohr, Mittelohr und Innenohr unterteilt. Zum ueren Ohr gehren Ohrmuschel (Pinna) und uerer Gehrgang (Meatus acusticus externus). Die Ohrmuschel besteht - mit Ausnahme des Ohrlppchens - aus Knorpeln. Sie enthlt auch Muskelgewebe, das beim Menschen nur noch rudimentr ausgebildet ist und nicht mehr wie bei vielen Tieren durch Bewegung der Ohrmuschel der Schallortung dient.

  11. 50 CFR 648.95 - Offshore Fishery Program in the SFMA.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Measures for the NE Multispecies and Monkfish Fisheries 648.95 Offshore Fishery Program in the SFMA. (a... fishing on a NE multispecies DAS in the NFMA, a Category F vessel that also possesses a NE multispecies... Category F vessels. (3) Vessels issued a Category F permit that are fishing under a NE multispecies DAS...

  12. 50 CFR 648.95 - Offshore Fishery Program in the SFMA.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Measures for the NE Multispecies and Monkfish Fisheries 648.95 Offshore Fishery Program in the SFMA. (a... fishing on a NE multispecies DAS in the NFMA, a Category F vessel that also possesses a NE multispecies... Category F vessels. (3) Vessels issued a Category F permit that are fishing under a NE multispecies DAS...

  13. The Effects of a Responsive Parenting Intervention on Parent-Child Interactions during Shared Book Reading

    ERIC Educational Resources Information Center

    Landry, Susan H.; Smith, Karen E.; Swank, Paul R.; Zucker, Tricia; Crawford, April D.; Solari, Emily F.

    2012-01-01

    This study examined mother-child shared book reading behaviors before and after participation in a random-assignment responsive parenting intervention called Play and Learning Strategies (PALS) that occurred during infancy (PALS I), the toddler-preschool (PALS II) period, or both as compared with a developmental assessment (DAS) intervention (DAS

  14. General Factor Loadings and Specific Effects of the Differential Ability Scales, Second Edition Composites

    ERIC Educational Resources Information Center

    Maynard, Jennifer L.; Floyd, Randy G.; Acklie, Teresa J.; Houston, Lawrence, III

    2011-01-01

    The purpose of this study was to investigate the "g" loadings and specific effects of the core and diagnostic composite scores from the Differential Abilities Scales, Second Edition (DAS-II; Elliott, 2007a). Scores from a subset of the DAS-II standardization sample for ages 3:6 to 17:11 were submitted to principal factor analysis. Four composites,…

  15. 75 FR 22073 - Fisheries of the Northeastern United States; Atlantic Sea Scallop Fishery; Framework Adjustment 21

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-27

    ... (access area) trip allocations; DAS adjustments if an access area yellowtail flounder (yellowtail) TAC is.... Open Area DAS Adjustment if Access Area Yellowtail TAC Is Attained Under the Northeast Multispecies FMP, 10 percent of the Southern New England (SNE) yellowtail TAC is allocated to scallop vessels...

  16. 50 CFR 648.86 - NE Multispecies possession restrictions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ...), will be multiplied by 3. (g) Yellowtail flounder—(1) CC/GOM and SNE/MA yellowtail flounder landing... to 250 lb (113.6 kg) of yellowtail flounder per DAS, or any part of a DAS, up to a maximum possession... Area on the same trip is subject to the more restrictive yellowtail flounder trip limit (i.e.,...

  17. Einparkassistenz

    NASA Astrophysics Data System (ADS)

    Katzwinkel, Reiner; Auer, Richard; Brosig, Stefan; Rohlfs, Michael; Schning, Volkmar; Schroven, Frank; Schwitters, Frank; Wuttke, Ulrich

    Einparken ist fr viele Fahrer eine langweilige oder gar anstrengende Aufgabe: Es ist zunchst erforderlich, eine fr das Fahrzeug passende Parklcke zu fnden, um unntige Fehlversuche zu vermeiden. Anschlieend muss das Fahrzeug - teils unter Beobachtung - in mitunter unbekannter Umgebung bei minimaler Beeinfussung des restlichen Verkehrs zgig positioniert werden.

  18. Multigroup Confirmatory Factor Analysis of U.S. and Italian Children's Performance on the PASS Theory of Intelligence as Measured by the Cognitive Assessment System

    ERIC Educational Resources Information Center

    Naglieri, Jack A.; Taddei, Stefano; Williams, Kevin M.

    2013-01-01

    This study examined Italian and U.S. children's performance on the English and Italian versions, respectively, of the Cognitive Assessment System (CAS; Naglieri & Conway, 2009; Naglieri & Das, 1997), a test based on a neurocognitive theory of intelligence entitled PASS (Planning, Attention, Simultaneous, and Successive; Naglieri & Das, 1997;…

  19. 77 FR 26512 - Proposed Information Collection; Comment Request; Northeast Multispecies Days-at-Sea Leasing Program

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-04

    ... (DAS) leasing requirements at Sec. 648.82(k) form the basis for this collection of information. The NE Multispecies DAS leasing program was implemented in 2004 as a result of Amendment 13 (69 FR 22906) which... Multispecies Days-at-Sea Leasing Program AGENCY: National Oceanic and Atmospheric Administration...

  20. Continuing German in Grade Five: MLA Teacher's Guide. A Course of Study Including Methods, Materials, and Aids for Teaching German to Fifth-Grade Pupils.

    ERIC Educational Resources Information Center

    Memming, Agnes K.; And Others

    This teacher's guide, for use in a fifth-grade German course, contains 12 units of instructional materials which concentrate on the development of basic audiolingual skills. Each of the units consists of conversational skits, dialogue adaptation, directed dialogue review, and classroom drills. Units include: (1) Das Aufstehen und das Fruhstuck,

  1. Evaluating the Invariance and Validity of the Structure of Dysfunctional Attitudes in an Adolescent Population

    ERIC Educational Resources Information Center

    Prenoveau, Jason M.; Zinbarg, Richard E.; Craske, Michelle G.; Mineka, Susan; Griffith, James W.; Rose, Raphael D.

    2009-01-01

    Form A of the Dysfunctional Attitude Scale (DAS-A), a self-report measure of depressive beliefs, is widely used to test Beck's cognitive model of depression. The present study is the first to evaluate the DAS-A factor structure in an adolescent population of 542 high school juniors and the first to examine a hierarchical model. Findings support

  2. 78 FR 65971 - Fisheries of the Northeastern United States; Monkfish Fisheries Management Plan; Reallocation of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-04

    ...) (70 FR 21927, April 28, 2005) established the Monkfish Research Set-Aside (RSA) Program, which annually sets-aside 500 of the total monkfish DAS as RSA DAS to be used to conduct monkfish research. Amendment 2 also established the Monkfish Exemption Program, which requires NMFS to make any unallocated...

  3. Synthesis of radiolabeled mycotoxins. Annual report, 1 December 1985-30 November 1986

    SciTech Connect

    Kraus, G.A.

    1987-02-01

    The synthesis of labeled trichothecenes by degradation of diaceotxy scirpenol (DAS) is the subject of this report. The DAS was acetylated and deoxygenated to provide a diene which was selectively oxidized, deuterated, and epoxidized. This enone has been reduced. The remaining steps, separation and acetate removal, are in progress.

  4. Screening for Aggression Using the Draw a Story Assessment. Brief Report

    ERIC Educational Resources Information Center

    Earwood, Cheryl; Fedorko, Melinda; Holzman, Eileen; Montanari, Linda; Silver, Rawley

    2004-01-01

    The purpose of this study was to find out if the Draw a Story (DAS) assessment can be used as a screening technique to identify children and adolescents at risk for aggression. Four art therapists presented the DAS tasks to 30 students with histories of aggressive behavior and to 181 students with no histories of aggression. After the 211

  5. The intelligent distributed acoustic sensor (withdrawal notice)

    NASA Astrophysics Data System (ADS)

    Parker, Tom R.; Gillies, Arran; Shatalin, Sergey V.; Farhadiroushan, Mahmoud

    2014-05-01

    Distributed Acoustic Sensing (DAS) technology has progressed rapidly from being capable of event detection only to faithfully capturing the full acoustic signal (amplitude, frequency and phase) at all points along the sensing fibre. In this paper we demonstrate the performance of one such sensor and describe how the unique nature of DAS data enables a range of ground-breaking industrial applications.

  6. The intelligent distributed acoustic sensing

    NASA Astrophysics Data System (ADS)

    Parker, Tom R.; Gillies, Arran; Shatalin, Sergey V.; Farhadiroushan, Mahmoud

    2014-05-01

    Distributed Acoustic Sensing (DAS) technology has progressed rapidly from being capable of event detection only to faithfully capturing the full acoustic signal (amplitude, frequency and phase) at all points along the sensing fibre. In this paper we demonstrate the performance of one such sensor and describe how the unique nature of DAS data enables a range of ground-breaking industrial applications.

  7. Wege in die Zukunft

    NASA Astrophysics Data System (ADS)

    Kauermann, Gran; Mosler, Karl

    Die Zukunft stellt groe Herausforderungen an die Arbeit der Deutschen Statistischen Gesellschaft. Sie betreffen die gestiegenen Anforderungen der Nutzer von Statistik, die Kommunikationsmglichkeiten des Internets sowie die Dynamik der statistischen Wissenschaften und ihrer Anwendungsgebiete. Das Kapitel 5 beschreibt, wie sich die Gesellschaft diesen Herausforderungen stellt und welche Ziele sie sich in der wissenschaftlichen Zusammenarbeit und im Kampf gegen das Innumeratentum gesetzt hat.

  8. General Factor Loadings and Specific Effects of the Differential Ability Scales, Second Edition Composites

    ERIC Educational Resources Information Center

    Maynard, Jennifer L.; Floyd, Randy G.; Acklie, Teresa J.; Houston, Lawrence, III

    2011-01-01

    The purpose of this study was to investigate the "g" loadings and specific effects of the core and diagnostic composite scores from the Differential Abilities Scales, Second Edition (DAS-II; Elliott, 2007a). Scores from a subset of the DAS-II standardization sample for ages 3:6 to 17:11 were submitted to principal factor analysis. Four composites,

  9. Depression and Anxiety Symptoms: Onset, Developmental Course and Risk Factors during Early Childhood

    ERIC Educational Resources Information Center

    Cote, Sylvana M.; Boivin, Michel; Liu, Xuecheng; Nagin, Daniel S.; Zoccolillo, Mark; Tremblay, Richard E.

    2009-01-01

    Background: Depressive and anxiety disorders are among the top ten leading causes of disabilities. We know little, however, about the onset, developmental course and early risk factors for depressive and anxiety symptoms (DAS). Objective: Model the developmental trajectories of DAS during early childhood and to identify risk factors for atypically

  10. Informatik in einem Frauenstudiengang

    NASA Astrophysics Data System (ADS)

    Schreiber, Gerlinde

    Informatik in einem Frauenstudiengang? Hat das Geschlecht der Studierenden einen Einfluss auf einen inhaltlich nach GI-Empfehlungen konzipierten Studiengang Informatik? Dieser Frage geht der Beitrag nach und erläutert das Konzept und die Erfahrungen aus dem Internationalen Frauenstudiengang Informatik an der Hochschule Bremen.

  11. 75 FR 3234 - Issuance of an Experimental Use Permit

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-20

    ... and the genetic material necessary (vector PHP8999) for its production in corn event TC1507... production in corn event DAS-59122-7 (OECD Unique Identifier: DAS-59122-7) 3. Bacillus thuringiensis Cry1Ab delta-endotoxin protein and the genetic material necessary (vector pZO1502) for its production in...

  12. 75 FR 57778 - Issuance of an Experimental Use Permit

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-09-22

    ... genetic material necessary for its production (vector pSYN12274) in event 5307 corn (SYN- 53 7-1) and... material (as contained in plasmid vector pZO1502) necessary for its production in corn, 2) [DAS- 59122-7... for their production in Event DAS-59122-7 corn, 3) Bacillus thuringiensis Vip3Aa20 and the...

  13. Multigroup Confirmatory Factor Analysis of U.S. and Italian Children's Performance on the PASS Theory of Intelligence as Measured by the Cognitive Assessment System

    ERIC Educational Resources Information Center

    Naglieri, Jack A.; Taddei, Stefano; Williams, Kevin M.

    2013-01-01

    This study examined Italian and U.S. children's performance on the English and Italian versions, respectively, of the Cognitive Assessment System (CAS; Naglieri & Conway, 2009; Naglieri & Das, 1997), a test based on a neurocognitive theory of intelligence entitled PASS (Planning, Attention, Simultaneous, and Successive; Naglieri & Das, 1997;

  14. The Dating Anxiety Scale for Adolescents: Scale Development and Associations with Adolescent Functioning

    ERIC Educational Resources Information Center

    Glickman, Alissa R.; La Greca, Annette M.

    2004-01-01

    Given the importance of romantic and dating relationships during adolescence, the purpose of the study was to develop and evaluate the psychometric properties of the Dating Anxiety Scale for Adolescents (DAS-A). Participants were 757 high school students (56% girls, ages 15 to 18 years). Adolescents completed the DAS-A, the Social Anxiety Scale

  15. Depression and Anxiety Symptoms: Onset, Developmental Course and Risk Factors during Early Childhood

    ERIC Educational Resources Information Center

    Cote, Sylvana M.; Boivin, Michel; Liu, Xuecheng; Nagin, Daniel S.; Zoccolillo, Mark; Tremblay, Richard E.

    2009-01-01

    Background: Depressive and anxiety disorders are among the top ten leading causes of disabilities. We know little, however, about the onset, developmental course and early risk factors for depressive and anxiety symptoms (DAS). Objective: Model the developmental trajectories of DAS during early childhood and to identify risk factors for atypically…

  16. 24 CFR 17.110 - Determination of indebtedness and appeal from determination.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... determination. (a) Following the hearing or the review of the record, the DAS or designee will issue a written decision which includes the supporting rationale for the decision. The decision of the DAS or designee is the final agency action with regard to the particular administrative offset. (b) Copies of the...

  17. 48 CFR 833.212 - Contracting officer's duties upon appeal.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... copies of the notice of appeal and the final decision letter to the DAS for A&MM. (In cases of... appeal and the final decision letter need not be transmitted to the DAS for A&MM but instead should...

  18. Differential absorption and scattering sensitivity predictions

    NASA Technical Reports Server (NTRS)

    Thompson, R. T., Jr.

    1976-01-01

    A set of general equations for evaluating the sensitivity of the Differential Absorption and Scattering (DAS) technique based upon a conventional analysis of statistical errors is derived. The equations are put in a proper form for evaluating total column density and range resolved concentration measurements of a variety of atmospheric species. The derived equation are subsequently used to analyze the sensitivity of DAS in three specific applications assuming realistic parameters for the optical and electronic components of proposed DAS systems. The three DAS applications evaluated are: (1) measurement of nitrogen at ground levels over a horizontal path; (2) measurement of atmospheric ozone depletion in the wake of a jet engine at 20 km altitude; and (3) measurements of the ozone distribution in the atmosphere from an orbiting space platform, in a downward viewing mode. The results of this study have shown that with reasonable laser energy and telescope receiver dimensions, DAS is capable of meeting requirements for performing these measurements.

  19. Influence of NaOH and thermal pretreatment on dewatered activated sludge solubilisation and subsequent anaerobic digestion: Focused on high-solid state.

    PubMed

    Zhang, Shuting; Guo, Haigang; Du, Lianzhu; Liang, Junfeng; Lu, Xuebin; Li, Nan; Zhang, Keqiang

    2015-06-01

    In this study, the influence of NaOH and thermal pretreatment of dewatered activated sludge (DAS) on the high-solid solubilisation and anaerobic digestion was separately investigated by monitoring common parameters. The results indicated that COD, proteins and carbohydrates were efficiently solubilised in both NaOH and thermal pretreated DAS samples. For NaOH pretreatment, the concentrations of volatile fatty acids (VFAs) and total ammonium nitrogen (TAN) firstly increased followed by decreasing with NaOH dose increasing. However, they decreased with the severity of thermal pretreatment. During the batch digestion experiments (at 37C), for 80mg NaOHg(-1) total solid (TS) DAS pretreatment it resulted in a 6.99% decrease in cumulative methane yield (CMY) compared to untreated DAS. While for 80, 100, 120C and 20mg NaOH pretreatment, CMY increased by 15%, 42%, 71% and 35%, respectively, in comparison to untreated DAS. PMID:25768420

  20. Heterogeneous Disease Trajectories Explain Variable Radiographic, Function and Quality of Life Outcomes in the Canadian Early Arthritis Cohort (CATCH)

    PubMed Central

    Barnabe, Cheryl; Sun, Ye; Boire, Gilles; Hitchon, Carol A.; Haraoui, Boulos; Thorne, J. Carter; Tin, Diane; van der Heijde, Désirée; Curtis, Jeffrey R.; Jamal, Shahin; Pope, Janet E.; Keystone, Edward C.; Bartlett, Susan; Bykerk, Vivian P.

    2015-01-01

    Our objective was to identify distinct trajectories of disease activity state (DAS) and assess variation in radiographic progression, function and quality of life over the first two years of early rheumatoid arthritis (ERA). The CATCH (Canadian early ArThritis CoHort) is a prospective study recruiting ERA patients from academic and community rheumatology clinics in Canada. Sequential DAS28 scores were used to identify five mutually exclusive groups in the cohort (n = 1,586) using growth-based trajectory modeling. Distinguishing baseline sociodemographic and disease variables, treatment required, and differences in radiographic progression and quality of life measures over two years were assessed. The trajectory groups are characterized as: Group 1 (20%) initial high DAS improving rapidly to remission (REM); Group 2 (21%) initial moderate DAS improving rapidly to REM; Group 3 (30%) initial moderate DAS improving gradually to low DAS; Group 4 (19%) initial high DAS improving continuously to low DAS; and Group 5 (10%) initial high DAS improving gradually only to moderate DAS. Groups differed significantly in age, sex, race, education, employment, income and presence of comorbidities. Group 5 had persistent steroid requirements and the highest biologic therapy use. Group 2 had lower odds (OR 0.22, 95%CI 0.09 to 0.58) and Group 4 higher odds (OR 1.94, 95%CI 0.90 to 4.20) of radiographic progression compared to Group 1. Group 1 had the best improvement in physical function (Health Assessment Questionnaire 1.08 (SD 0.68) units), Physical Component Score (16.4 (SD 10.2) units), Mental Component Score (9.7 (SD 12.5) units) and fatigue (4.1 (SD 3.3) units). In conclusion, distinct disease activity state trajectories explain variable outcomes in ERA. Early prediction of disease course to tailor therapy and addressing social determinants of health could optimize outcomes. PMID:26301589

  1. Characterization of red-near infrared transition for wheat and chickpea using 3 nm bandwidth data

    NASA Astrophysics Data System (ADS)

    Gupta, R. K.; Vijayan, D.; Prasad, T. S.

    2001-01-01

    Enhancement of space based capabilities to discriminate different crops and different varieties of a particular crop needs measurement of (i) the shift in red edge and (ii) the slope of the sudden rise of reflectance in 680 - 760 nm spectral region as a function of Days After Sowing (DAS). To develop the knowledge base for catering to the analysis of future space-based hyperspectral measurements, ground based measurements in 3 nm bandwidth in visible - near Infrared region together with corresponding Leaf Area Index (LAI) observations were taken over the Crop Growth Cycle (CGC) of Wheat and Chickpea. The red edge for wheat crop was at 679 nm for 25 DAS and reached the upper limit i.e., 693.7 nm at 84 DAS and thereafter shifted backward to 679 nm at 108 DAS. There was no change in red edge value of 684.9 nm during 40 to 49 DAS and of 687.8 nm during 55 to 71 DAS. The slope of Red to NIR transition for wheat varied from 0.457 to peak value of 0.784 during 25 to 71 DAS and thereafter decreased to 0.073 at 108 DAS. The peak of Red to Near Infrared (NIR) transition slope and Ratio Vegetation Index (RVI) occurred at the same time i.e., 71 DAS. However, the upper most value of red edge shift occurred at 84 DAS. Paper discusses the above aspects including role of mid point of Red to NIR transition, interrelationships among the Red-NIR transition Slope, Red Edge, LAI and RVI for wheat and chickpea.

  2. The nitrate time bomb: a numerical way to investigate nitrate storage and lag time in the unsaturated zone.

    PubMed

    Wang, L; Butcher, A S; Stuart, M E; Gooddy, D C; Bloomfield, J P

    2013-10-01

    Nitrate pollution in groundwater, which is mainly from agricultural activities, remains an international problem. It threatens the environment, economics and human health. There is a rising trend in nitrate concentrations in many UK groundwater bodies. Research has shown it can take decades for leached nitrate from the soil to discharge into groundwater and surface water due to the 'store' of nitrate and its potentially long travel time in the unsaturated and saturated zones. However, this time lag is rarely considered in current water nitrate management and policy development. The aim of this study was to develop a catchment-scale integrated numerical method to investigate the nitrate lag time in the groundwater system, and the Eden Valley, UK, was selected as a case study area. The method involves three models, namely the nitrate time bomb-a process-based model to simulate the nitrate transport in the unsaturated zone (USZ), GISGroundwater--a GISGroundwater flow model, and N-FM--a model to simulate the nitrate transport in the saturated zone. This study answers the scientific questions of when the nitrate currently in the groundwater was loaded into the unsaturated zones and eventually reached the water table; is the rising groundwater nitrate concentration in the study area caused by historic nitrate load; what caused the uneven distribution of groundwater nitrate concentration in the study area; and whether the historic peak nitrate loading has reached the water table in the area. The groundwater nitrate in the area was mainly from the 1980s to 2000s, whilst the groundwater nitrate in most of the source protection zones leached into the system during 1940s-1970s; the large and spatially variable thickness of the USZ is one of the major reasons for unevenly distributed groundwater nitrate concentrations in the study area; the peak nitrate loading around 1983 has affected most of the study area. For areas around the Bowscar, Beacon Edge, Low Plains, Nord Vue, Dale Springs, Gamblesby, Bankwood Springs, and Cliburn, the peak nitrate loading will arrive at the water table in the next 34 years; statistical analysis shows that 8.7 % of the Penrith Sandstone and 7.3 % of the St Bees Sandstone have not been affected by peak nitrate. This research can improve the scientific understanding of nitrate processes in the groundwater system and support the effective management of groundwater nitrate pollution for the study area. With a limited number of parameters, the method and models developed in this study are readily transferable to other areas. PMID:23801341

  3. Assessment of heavy metal and organic contaminants levels along the Libyan coast using transplanted mussels (Mytilus galloprovincialis).

    PubMed

    Galgani, Francois; Chiffoleau, Jean Francois; Barrah, Mahmoud; Drebika, Usama; Tomasino, Corinne; Andral, Bruno

    2014-10-01

    Within the framework of the MYTIOR project in 2009, heavy metals and organic compounds contaminations were assessed in transplanted mussels in 16 different stations along the coasts of Libya. These stations were located at miles offshore industrial/urban sources but in open sea providing original results related to the background contamination rather than linked to a specific coastal source of pollutants. Results indicated mercury (Hg, 0.045-0.066 mg/kg dry weight (dw)), lead (Pb, 0.44-0, 71 mg/kg dw) and copper (Cu, 3.56-4.21 mg/kg dw) were in the same range or at lower value than control for all stations. Chromium (Cr) in Meleta (3.08 mg/kg dw) and Bomba (3.80 mg/kg dw) and Cadmium values in all stations (1.21-2.41 mg/kg dw) were above control. Meleta, stations from the gulf of Syrt and the three eastern stations were the most affected stations by nickel (max at 5.83 mg/kg dw in Syrt) when zinc was in the same range (141-197 mg/kg dw) and above the control (92 mg/kg dw) at all stations. Polycyclic aromatic hydrocarbon (PAH) levels were found in the range of 16.8-42.8 mg/kg (dry weight) indicating low levels along the Libyan coast with acenaphthene and benzo (a, b, k) pyrenes detected mainly in western Libya. The study of PAH ratios indicated a mixed petrogenic/pyrolytic origin. The only polychlorinated biphenyls (PCBs) found in Libya were PCB 101 in one location and PCB 153 in Tripoli, Garrapoli, Syrt, Ras Lanuf and Benghazi (1.2-1.9 μg/kg dw). Insecticides were lower than control in all stations except DDT, only detected in Misratah (3.5 μg/kg dw). Overall, the results indicated a low background contamination and a low pollution extent according to the environmental pressure occurring offshore the Libyan coast. PMID:24870291

  4. Bagless Transfer System Welder Data Acquisition Software

    Energy Science and Technology Software Center (ESTSC)

    2003-09-30

    The Bagless Transfer System Welder Data Acquisition Software (BTS DAS) was developed by SRTC to replace a strip chart recorder that has been in place since the design of the BTS. During the welding process, critical weld parameters such as weld current and voltage, can give valuable information about the weld. In the past, weld data from the TID welding process, has been monitored using strip chart recorders. The data from the weld process, recordedmore » on the strip chart recorder traces, are reviewed to analyze the weld. The BTS DAS improves this technology by digitizing the weld data which allows for automation of the analysis process. Also, the data files are now stored digitally as well as a hard copy printout, so they can be reanalyzed if needed. The BTS DAS performs the necessary functions to perform the data acquisition functions during the BTS Welding Process. It is important to monitor the critical weld parameters, current and voltage, during a weld as they can be used to set acceptance criteria for weld acceptance. The software monitors and records the weld current, voltage, and RPM data. The welder DAS is a passive device and does not control the welder. The BTS control system interfaces directly with the welder and the BTS DAS. Digital handshaking is used between the BTS DAS and the BTS control system to ensure that the DAS is ready to weld prior to allowing the operator to initiate the welding process.« less

  5. Medical Students' Perceptions of Dementia after Participation in Poetry Workshop with People with Dementia

    PubMed Central

    Garrie, Alaina J.; Goel, Shruti; Forsberg, Martin M.

    2016-01-01

    Purpose. Researchers assessed whether medical students' participation in a poetry workshop with people with Alzheimer's disease and related dementias (ADRD) affected their attitudes towards persons with ADRD. Objective. To add to the growing body of research summarizing the impact of nonclinical interventions on medical students' perspectives about people with ADRD. Design. Researchers used dementia attitudes scale (DAS) and interpretive phenomenological analysis (IPA) to analyze participants' attitudes. Setting. Osteopathic medical school and dementia care unit in the state of New Jersey. Participants. Eleven out of fourteen medical students completed the study. Measurements. Emerging themes were classified from the postintervention semistructured interviews and descriptive statistics were used to compare the preintervention to postintervention DAS. Results. Researchers found statistically significant differences between preintervention and postintervention DAS scores. Study participants scored a preintervention DAS mean, 107.09 (SD = 11.85), that changed positively and significantly to the postintervention DAS mean, 121.82 (SD = 10.38). DAS subdomains, “comfort” (P = 0.002) and “knowledge” (P = 0.01), and eleven of the twenty DAS items underwent a positive and statistically significant shift from preintervention to postintervention. IPA of the interviews yielded five primary and five secondary themes, supporting the measured statistical outcomes. Conclusion. Medical students' participation in a poetry workshop, with people with ADRD, positively impacts their attitudes. PMID:26977333

  6. Individual and combined effects of fumonisin B1 present in Fusarium moniliforme culture material and diacetoxyscirpenol or ochratoxin A in turkey poults.

    PubMed

    Kubena, L F; Edrington, T S; Harvey, R B; Phillips, T D; Sarr, A B; Rottinghaus, G E

    1997-02-01

    The individual and combined effects of feeding diets containing 300 mg fumonisin B1 (FB1), and 4 mg diacetoxyscirpenol (DAS) or 3 mg ochratoxin A (OA) were evaluated in two experiments using female turkey poults (Nicholas Large Whites) from day of hatch to 3 wk of age. When compared with controls, body weight gains were reduced 30% (Study 1) and 24% (Study 2) by FB1, 30% by DAS, 8% by OA, 46% by the FB1 and DAS combination, and 37% by the FB1 and OA combination. The efficiency of feed utilization was adversely affected by all treatments except FB1 in Experiment 2. Relative weights of the liver were significantly increased by all treatments except the DAS treatment. Serum concentrations of cholesterol were decreased and activities of aspartate aminotransferase and lactate dehydrogenase were increased and several hematological values were altered in poults fed FB1 alone and in combination with either DAS or OA. Results indicate additive or less than additive toxicity, but not toxic synergy, when poults are fed diets containing 300 mg FB1, and 4 mg DAS or 3 mg OA/kg of diet. The likelihood of encountering FB1, DAS, or OA at these concentrations in finished feed is small. However, under field conditions, other stress factors could alter the impact of these mycotoxins on the health and performance of poultry. PMID:9057204

  7. Bagless Transfer System Welder Data Acquisition Software

    SciTech Connect

    2003-09-30

    The Bagless Transfer System Welder Data Acquisition Software (BTS DAS) was developed by SRTC to replace a strip chart recorder that has been in place since the design of the BTS. During the welding process, critical weld parameters such as weld current and voltage, can give valuable information about the weld. In the past, weld data from the TID welding process, has been monitored using strip chart recorders. The data from the weld process, recorded on the strip chart recorder traces, are reviewed to analyze the weld. The BTS DAS improves this technology by digitizing the weld data which allows for automation of the analysis process. Also, the data files are now stored digitally as well as a hard copy printout, so they can be reanalyzed if needed. The BTS DAS performs the necessary functions to perform the data acquisition functions during the BTS Welding Process. It is important to monitor the critical weld parameters, current and voltage, during a weld as they can be used to set acceptance criteria for weld acceptance. The software monitors and records the weld current, voltage, and RPM data. The welder DAS is a passive device and does not control the welder. The BTS control system interfaces directly with the welder and the BTS DAS. Digital handshaking is used between the BTS DAS and the BTS control system to ensure that the DAS is ready to weld prior to allowing the operator to initiate the welding process.

  8. Diallyl sulfide inhibits diethylstilbesterol-induced DNA adducts in the breast of female ACI rats.

    PubMed

    Green, M; Wilson, C; Newell, O; Sadrud-Din, S; Thomas, R

    2005-09-01

    Diethylstilbestrol (DES) is metabolized to reactive intermediates that produce DNA adducts and ultimately cancer. Diallyl sulfide (DAS) has been shown to inhibit the metabolism of several procarcinogens. The ability of DES to produce DNA adducts in microsomal, mitochondrial, and nuclear in vitro metabolic systems and in the breast of female ACI rats, as well as ability of DAS to inhibit DNA adducts were investigated. Microsomes, mitochondria, and nuclei isolated from breast tissue of female ACI rats were used to catalyze oxidation reactions. Female ACI rats were treated i.p. as follows: (1) corn oil, (2) 200mg/kg DES, (3) 200mg/kg DES/200mg/kg of DAS, (4) 200mg/kg DES/400mg/kg DAS. DES produced DNA adducts in each metabolic system. The relative adduct levels were 2.1 x 10(-4), 6.2 x 10(-6), and 2.9 x 10(-7) in microsomal, mitochondrial, and nuclear reactions, respectively. DAS inhibited DNA adducts in each metabolic system. The percent inhibition ranged from 86% in microsomes to 93% in nuclei. DES produced DNA adducts in mtDNA and nDNA. DAS completely inhibited the DES-induced mtDNA adducts and caused a dose dependent decrease in nDNA adduct formation. These findings suggest that DAS could inhibit DES-induced breast cancer by inhibiting its metabolism. PMID:15989972

  9. Coherence-Weighted Synthetic Focusing Applied to Photoacoustic Imaging Using a High-Frequency Annular-Array Transducer.

    PubMed

    Chitnis, Parag V; Aristizbal, Orlando; Filoux, Erwan; Sampathkumar, Ashwin; Mamou, Jonathan; Ketterling, Jeffrey A

    2016-01-01

    This paper presents an adaptive synthetic-focusing scheme that, when applied to photoacoustic (PA) data acquired using an annular array, improves focusing across a greater imaging depth and enhances spatial resolution. The imaging system was based on a 40-MHz, 5-element, annular-array transducer with a focal length of 12 mm and an 800-m diameter hole through its central element to facilitate coaxial delivery of 532-nm laser. The transducer was raster-scanned to facilitate 3D acquisition of co-registered ultrasound and PA image data. Three synthetic-focusing schemes were compared for obtaining PA A-lines for each scan location: delay-and-sum (DAS), DAS weighted with a coherence factor (DAS + CF), and DAS weighted with a sign-coherence factor (DAS + SCF). Bench-top experiments that used an 80-m hair were performed to assess the enhancement provided by the two coherence-based schemes. Both coherence-based schemes increased the signal-to-noise ratio by approximately 10 dB. When processed using the DAS-only scheme, the lateral dimension of the hair in a PA image with 20 dB dynamic range was between 300 m and 1 mm for imaging depth ranging from 8 to 20 mm. In comparison, the DAS + CF scheme resulted in a lateral dimension of 200 to 450 m over the same range. The DAS + SCF synthetic focusing further improved the smallest-resolvable dimension, which was between 150 and 400 m over the same range of imaging depth. When used on PA data obtained from a 12-day-old mouse embryo, the DAS + SCF processing improved visualization of neurovasculature. PMID:25925675

  10. A novel PET marker for in vivo quantification of myelination.

    PubMed

    Wu, Chunying; Wang, Changning; Popescu, Daniela C; Zhu, Wenxia; Somoza, Eduardo A; Zhu, Junqing; Condie, Allison G; Flask, Christopher A; Miller, Robert H; Macklin, Wendy; Wang, Yanming

    2010-12-15

    C-11-labeled N-methyl-4,4'-diaminostilbene ([(11)C]MeDAS) was synthesized and evaluated as a novel radiotracer for in vivo microPET imaging of myelination. [(11)C]MeDAS exhibits optimal lipophilicity for brain uptake with a logP(oct) value of 2.25. Both in vitro and ex vivo staining exhibited MeDAS accumulation in myelinated regions such as corpus callosum and striatum. The corpus callosum region visualized by MeDAS is much larger in the hypermyelinated Plp-Akt-DD mouse brain than in the wild-type mouse brain, a pattern that was also consistently observed in Black-Gold or MBP antibody staining. Ex vivo autoradiography demonstrated that [(11)C]MeDAS readily entered the mouse brain and selectively labeled myelinated regions with high specificity. Biodistribution studies showed abundant initial brain uptake of [(11)C]MeDAS with 2.56% injected dose/whole brain at 5 min post injection and prolonged retention in the brain with 1.37% injected dose/whole brain at 60 min post injection. An in vivo pharmacokinetic profile of [(11)C]MeDAS was quantitatively analyzed through a microPET study in an Plp-Akt-DD hypermyelinated mouse model. MicroPET studies showed that [(11)C]MeDAS exhibited a pharmacokinetic profile that readily correlates the radioactivity concentration to the level of myelination in the brain. These studies suggest that MeDAS is a sensitive myelin probe that provides a direct means to detect myelin changes in the brain. Thus, it can be used as a myelin-imaging marker to monitor myelin pathology in vivo. PMID:21071233

  11. A Novel PET Marker for In Vivo Quantification of Myelination

    PubMed Central

    Wu, Chunying; Wang, Changing; Popescu, Daniela; Zhu, Wenxia; Somoza, Eduardo; Zhu, Junqing; Condie, Allison G.; Flask, Chris; Miller, Robert H.; Macklin, Wendy; Wang, Yanming

    2010-01-01

    C-11-Labeled N-methyl-4,4?-diaminostilbene ([11C]MeDAS) was synthesized and evaluated as a novel radiotracer for in vivo microPET imaging of myelination. [11C]MeDAS exhibits optimal lipophilicity for brain uptake with a logPoct value of 2.25. Both in vitro and ex vivo staining exhibited MeDAS accumulation in myelinated regions such as corpus callosum and striatum. The corpus callosum region visualized by MeDAS is much larger in the hypermyelinated Plp-Akt-DD mouse brain than in the wild-type mouse brain, a pattern that was also consistently observed in Black-Gold or MBP antibody staining. Ex vivo autoradiography demonstrated that [11C]MeDAS readily entered the mouse brain and selectively labeled myelinated regions with high specificity. Biodistribution studies showed abundant initial brain uptake of [11C]MeDAS with 2.56% injected dose/whole brain at 5 min post injection and prolonged retention in the brain with 1.37% injected dose/whole brain at 60 min post injection. An in vivo pharmacokinetic profile of [11C]MeDAS was quantitatively analyzed through a microPET study in an Plp-Akt-DD hypermyelinated mouse model. MicroPET studies showed that [11C]MeDAS exhibited a pharmacokinetic profile that readily correlates the radioactivity concentration to the level of myelination in the brain. These studies suggest that MeDAS is a sensitive myelin probe that provides a direct means to detect myelin changes in the brain. Thus, it can be used as a myelin-imaging marker to monitor myelin pathology in vivo. PMID:21071233

  12. Evaluation of Transport in the Lower Tropical Stratosphere in a Global Chemistry and Transport Model

    NASA Technical Reports Server (NTRS)

    Douglass, Anne R.; Schoeberl, Mark R.; Rood, Richard B.; Pawson, Steven

    2002-01-01

    A general circulation model (GCM) relies on various physical parameterizations and provides a solution to the atmospheric equations of motion. A data assimilation system (DAS) combines information from observations with a GCM forecast and produces analyzed meteorological fields that represent the observed atmospheric state. An off-line chemistry and transport model (CTM) can use winds and temperatures from a either a GCM or a DAS. The latter application is in common usage for interpretation of observations from various platforms under the assumption that the DAS transport represents the actual atmospheric transport. Here we compare the transport produced by a DAS with that produced by the particular GCM that is combined with observations to produce the analyzed fields. We focus on transport in the tropics and middle latitudes by comparing the age-of-air inferred from observations of SF6 and CO2 with the age-of-air calculated using GCM fields and DAS fields. We also compare observations of ozone, total reactive nitrogen, and methane with results from the two simulations. These comparisons show that DAS fields produce rapid upward tropical transport and excessive mixing between the tropics and middle latitudes. The unrealistic transport produced by the DAS fields may be due to implicit forcing that is required by the assimilation process when there is bias between the GCM forecast and observations that are combined to produce the analyzed fields. For example, the GCM does not produce a quasi-biennial oscillation (QBO). The QBO is present in the analyzed fields because it is present in the observations, and systematic implicit forcing is required by the DAS. Any systematic bias between observations and the GCM forecast used to produce the DAS analysis is likely to corrupt the transport produced by the analyzed fields. Evaluation of transport in the lower tropical stratosphere in a global chemistry and transport model.

  13. Diallylsulfide attenuates excessive collagen production and apoptosis in a rat model of bleomycin induced pulmonary fibrosis through the involvement of protease activated receptor-2

    SciTech Connect

    Kalayarasan, Srinivasan Sriram, Narayanan; Soumyakrishnan, Syamala; Sudhandiran, Ganapasam

    2013-09-01

    Pulmonary fibrosis (PF) can be a devastating lung disease. It is primarily caused by inflammation leading to severe damage of the alveolar epithelial cells. The pathophysiology of PF is not yet been clearly defined, but studying lung parenchymal injury by involving reactive oxygen species (ROS) through the activation of protease activated receptor-2 (PAR-2) may provide promising results. PAR-2 is a G-protein coupled receptor is known to play an important role in the development of PF. In this study, we investigated the inhibitory role of diallylsulfide (DAS) against ROS mediated activation of PAR-2 and collagen production accompanied by epithelial cell apoptosis. Bleomycin induced ROS levels may prompt to induce the expression of PAR-2 as well as extracellular matrix proteins (ECM), such as MMP 2 and 9, collagen specific proteins HSP-47, α-SMA, and cytokines IL-6, and IL-8RA. Importantly DAS treatment effectively decreased the expression of all these proteins. The inhibitory effect of DAS on profibrotic molecules is mediated by blocking the ROS level. To identify apoptotic signaling as a mediator of PF induction, we performed apoptotic protein expression, DNA fragmentation analysis and ultrastructural details of the lung tissue were performed. DAS treatment restored all these changes to near normalcy. In conclusion, treatment of PF bearing rats with DAS results in amelioration of the ROS production, PAR-2 activation, ECM production, collagen synthesis and alveolar epithelial cell apoptosis during bleomycin induction. We attained the first evidence that treatment of DAS decreases the ROS levels and may provide a potential therapeutic effect attenuating bleomycin induced PF. - Highlights: • DAS inhibits PAR-2 activity; bleomycin stimulates PAR-2 activity. • Increase in PAR-2 activity is correlated with pulmonary fibrosis • DAS reduces pro-inflammatory activity linked to facilitating pulmonary fibrosis. • DAS inhibits apoptosis of alveolar epithelial cells.

  14. Cytotoxicity of diacetoxyscirpenol is associated with apoptosis by activation of caspase-8 and interruption of cell cycle progression by down-regulation of cdk4 and cyclin B1 in human Jurkat T cells

    SciTech Connect

    Jun, Do Youn; Kim, Jun Seok; Park, Hae Sun; Song, Woo Sun; Bae, Young Seuk; Kim, Young Ho . E-mail: ykim@knu.ac.kr

    2007-07-15

    To understand the mechanism underlying T-cell toxicity of diacetoxyscirpenol (DAS) from Fusarium sambucinum, its apoptogenic as well as growth retardation activity was investigated in human Jurkat T cells. Exposure to DAS (0.01-0.15 {mu}M) caused apoptotic DNA fragmentation along with caspase-8 activation, Bid cleavage, mitochondrial cytochrome c release, activation of caspase-9 and caspase-3, and PARP degradation, without any alteration in the levels of Fas or FasL. Under these conditions, necrosis was not accompanied. The cytotoxicity of DAS was not blocked by the anti-Fas neutralizing antibody ZB-4. Although the DAS-induced apoptotic events were completely prevented by overexpression of Bcl-xL, the cells overexpressing Bcl-xL were unable to divide in the presence of DAS, resulting from the failure of cell cycle progression possibly due to down-regulation in the protein levels of cdk4 and cyclin B1. The DAS-mediated apoptosis and activation of caspase-8, -9, and -3 were abrogated by either pan-caspase inhibitor (z-VAD-fmk) or caspase-8 inhibitor (z-IETD-fmk). While the DAS-mediated apoptosis and activation of caspase-9 and caspase-3 were slightly suppressed by the mitochondrial permeability transition pore inhibitor (CsA), both caspase-8 activation and Bid cleavage were not affected by CsA. The activated normal peripheral T cells possessed a similar susceptibility to the cytotoxicity of DAS. These results demonstrate that the T-cell toxicity of DAS is attributable to not only apoptosis initiated by caspase-8 activation and subsequent mitochondrion-dependent or -independent activation of caspase cascades, which can be regulated by Bcl-xL, but also interruption of cell cycle progression caused by down-regulation of cdk4 and cyclin B1 proteins.

  15. Magnetic white dwarf stars in the Sloan Digital Sky Survey

    NASA Astrophysics Data System (ADS)

    Kepler, S. O.; Pelisoli, I.; Jordan, S.; Kleinman, S. J.; Koester, D.; Klebi, B.; Peanha, V.; Castanheira, B. G.; Nitta, A.; Costa, J. E. S.; Winget, D. E.; Kanaan, A.; Fraga, L.

    2013-03-01

    To obtain better statistics on the occurrence of magnetism among white dwarfs, we searched the spectra of the hydrogen atmosphere white dwarf stars (DAs) in the Data Release 7 of the Sloan Digital Sky Survey (SDSS) for Zeeman splittings and estimated the magnetic fields. We found 521 DAs with detectable Zeeman splittings, with fields in the range from around 1 to 733 MG, which amounts to 4 per cent of all DAs observed. As the SDSS spectra have low signal-to-noise ratios, we carefully investigated by simulations with theoretical spectra how reliable our detection of magnetic field was.

  16. Kinetische Gastheorie

    NASA Astrophysics Data System (ADS)

    Heintze, Joachim

    In diesem Kapitel wollen wir ein Gas als System von vielen Teilchen betrachten und die Verbindung zwischen dieser mikroskopischen Betrachtungsweise und den makroskopischen Parametern (Druck p, Temperatur T und innere Energie U) herstellen.1 Damit werden wir einen tieferen Einblick in die Natur der Wrme gewinnen und auch die experimentell beobachteten Regelmigkeiten der spezifischen Wrmen erklren knnen. Danach werden wir nher untersuchen, wie die Ste zwischen den Gasmoleklen zu beschreiben sind und welche Konsequenzen sie haben. Das wird uns auf das Konzept des Boltzmannfaktors fhren, das auf fast allen Gebieten der Physik eine groe Rolle spielt.

  17. Wie die Sonne ins Kraftwerk kommt: Solarthermische Kraftwerke

    NASA Astrophysics Data System (ADS)

    Pitz-Paal, Robert

    2004-01-01

    Solarthermische Kraftwerke sammeln wie riesige Brennglser die Sonnenstrahlung und treiben damit eine Wrmekraftmaschine an. Drei Konstruktionsprinzipien haben sich heute durchgesetzt. Bereits im kommerziellen Einsatz sind Systeme mit schwenkbaren, verspiegelten Parabolrinnen, die das Sonnenlicht auf ein zentrales Absorberrohr konzentrieren. Durch dieses fliet ein Wrmetransportmedium. Beim Zentral-Receiver-System fokussiert ein Feld verstellbarer Spiegel das Sonnenlicht auf die Spitze eines Turms. Dort sitzt ein Receiver, den ein Wrmetransportmedium durchstrmt. Fr kleine, dezentrale Anlagen eignen sich Dish-Stirling-Systeme. Das sind schwenkbare, paraboloide Spiegelschsseln mit einem Stirling-Motor im Brennpunkt. Zentral-Receiver- und Dish-Stirling-Systeme sind noch im Entwicklungsstadium.

  18. Steam plasma jet for treatment of contaminated water with high-concentration 1,4-dioxane organic pollutants

    NASA Astrophysics Data System (ADS)

    Ni, G. H.; Zhao, Y.; Meng, Y. D.; Wang, X. K.; Toyoda, H.

    2013-02-01

    A steam plasma jet (SPJ) by using both water and 1,4-dioxane aqueous solution (DAS) as working medium was injected into contaminated water to decompose 1,4-dioxane. The optical emission spectroscopy analysis showed that the formation of the excited species CH* and C2* depended on the concentration of 1,4-dioxane. The influences of SPJ gas temperatures for different working mediums were discussed. The 1,4-dioxane decomposition was enhanced when DAS was used as working medium and SPJ was injected into DAS. Synthesis gas (a mixture of H2 and CO) and CO2 were the main products in gaseous effluents.

  19. Grundlagen der Vernetzung

    NASA Astrophysics Data System (ADS)

    Reif, Konrad

    Mit dem rasanten Fortschritt in der Computertechnik nimmt die Anzahl elektronischer Systeme immer weiter zu. Diese Entwicklung macht auch in der Kfz- Technik nicht halt. Das bedeutet aber auch, dass die Komplexitt eines Gesamtsystems - hier das System Fahrzeug - weiter steigt. Die Einzelsysteme, z. B. die Motorsteuerung, wurden dabei in den letzten Jahren in Details weiter verbessert. Innovationen werden aber vor allem durch das Zusammenspiel mehrerer Einzelsysteme erzielt. Damit die Vielzahl an Informationen, die mit den Einzelsystemen verwaltet werden, auch systembergreifend genutzt werden knnen, mssen die einzelnen Komponenten untereinander vernetzt werden. Je nachdem, welche Anforderungen (z. B. bertragungs sicherheit, Fehler toleranz, Kosten) gestellt werden, kommen verschiedene Kommunikationssysteme zum Einsatz.

  20. Meteorologie und Klimatologie

    NASA Astrophysics Data System (ADS)

    Malberg, Horst

    Auf der Basis der physikalischen Grundlagen (Strahlung, Luftbewegung, Wolken- und Niederschlagsbildung) sowie der verschiedenen Methoden der Wetterbeobachtung (Boden, Radiosonde, Satelliten, Radar) werden Wettersysteme und Wettervorhersage verstndlich erlutert. Die allgemeine atmosphrische Zirkulation verknpft das kurzlebige Wettergeschehen mit dem grorumigen Klima auf der Erde. Ausfhrungen ber Klimanderungen, orographische Windsysteme, Stadtklima, Luftverunreinigungen und Wetterbeeinflussung runden die Einfhrung in den aktuellen Stand der Meteorologie und Klimatologie ab. Fr die 3. Aufl. wurde vor allem der Abschnitt 'Zyklonen und Antizyklonen' aktualisiert und erweitert. Darber hinaus wurde das Lehrbuch um das Kapitel 'Aktuelle Klimaprobleme' ergnzt.

  1. Auf Proteinjagd in der T-Zelle: Einzelmolekl-Mikroskopie

    NASA Astrophysics Data System (ADS)

    Brameshuber, Mario; Mrtelmaier, Manuel

    2004-07-01

    Einzelne Molekle in lebenden Zellen mit Fluoreszenzmikroskopen zu beobachten, ist derzeit noch eine technische Herausforderung. Sie lohnt sich aber: So knnen erstmals die molekularen Bausteine des Lebens, etwa Proteine, bei ihren Aktivitten direkt verfolgt werden. Das erlaubt vllig neue Einblicke in die Funktionsmechanismen biologischer Zellen. Ein interessantes Forschungsobjekt sind die T-Zellen, die das Immunsystem steuern. Die Beobachtung einzelner Proteine kann das Rtsel lsen helfen, wie T-Zellen gefhrliche von ungefhrlichen Erregern unterscheiden knnen. Damit Einzelmolekl-Mikroskope routinemig in Biolabors eingesetzt werden knnen, mssen sie noch robuster, billiger und einfacher handhabbar werden.

  2. Automatische Bremsfunktionen

    NASA Astrophysics Data System (ADS)

    Wagner, Jochen

    Die Mglichkeiten elektronischer Bremssysteme gehen heute weit ber ihre ursprnglichen Aufgaben hinaus. Anfangs hatte das Antiblockiersystem (ABS) nur die Aufgabe, das Blockieren der Rder zu verhindern und damit die Lenkbarkeit des Fahrzeugs auch bei einer Vollbremsung zu gewhrleisten. Heute bernimmt es auch die Funktion der Bremskraftverteilung. Das Elektronische Stabilitts-Programm (ESP) bietet mit seiner Fhigkeit, unabhngig von der Bremspedalstellung Bremsdruck aufzubauen, eine Vielzahl von Mglichkeiten zum aktiven Bremseingriff. Ziel ist es,mit automatischen Bremseingriffen den Fahrer zu entlasten und damit mehr Komfort zu bieten. Einige Funktionen tragen aber auch zu mehr Sicherheit bei, da automatische Bremseingriffe im Notfall zu verkrzten Bremswegen fhren.

  3. Automatische Bremsfunktionen

    NASA Astrophysics Data System (ADS)

    Wagner, Jochen

    Die Mglichkeiten elektronischer Bremssysteme gehen heute weit ber ihre ursprnglichen Aufgaben hinaus. Anfangs hatte das Antiblockiersystem (ABS) nur die Aufgabe, das Blockieren der Rder zu verhindern und damit die Lenkbarkeit des Fahrzeugs auch bei einer Vollbremsung zu gewhrleisten. Heute bernimmt es auch die Funktion der Bremskraftverteilung. Das Elektronische Stabilitts-Programm (ESP) bietet mit seiner Fhigkeit, unabhngig von der Bremspedalstellung Bremsdruck aufzubauen, eine Vielzahl von Mglichkeiten zum aktiven Bremseingriff. Ziel ist es, mit automatischen Bremseingriffen den Fahrer zu entlasten und damit mehr Komfort zu bieten. Einige Funktionen tragen aber auch zu mehr Sicherheit bei, da automatische Bremseingriffe im Notfall zu verkrzten Bremswegen fhren.

  4. Field tests of the real-data acquisiton system for the NASA-LaRC differential absorption lidar

    NASA Technical Reports Server (NTRS)

    Butler, C.

    1984-01-01

    A data acquisition system (DAS) for the NASA/LaRC Differential Absorption Lidar (DIAL) was documented. This DAS is a dual LSI 11/23 set up where one computer retrieves data from the digitizers and other peripheral units, stores that data on magnetic tape, generates aerosol grayscales on a Trilog printer and passes data to the second computer. The second computer is dedicated to real time displays of the data in a variety of modes from raw data to range resolved ozone profiles. The DIAL DAS also has several new features.

  5. Web-based data acquisition and management system for GOSAT validation Lidar data analysis

    NASA Astrophysics Data System (ADS)

    Okumura, Hiroshi; Takubo, Shoichiro; Kawasaki, Takeru; Abdullah, Indra N.; Uchino, Osamu; Morino, Isamu; Yokota, Tatsuya; Nagai, Tomohiro; Sakai, Tetsu; Maki, Takashi; Arai, Kohei

    2012-11-01

    An web-base data acquisition and management system for GOSAT (Greenhouse gases Observation SATellite) validation lidar data analysis is developed. The system consists of data acquisition sub-system (DAS) and data management sub-system (DMS). DAS written in Perl language acquires AMeDAS ground-level meteorological data, Rawinsonde upper-air meteorological data, ground-level oxidant data, skyradiometer data, skyview camera images, meteorological satellite IR image data and GOSAT validation lidar data. DMS written in PHP language demonstrates satellite-pass date and all acquired data.

  6. Wissen und Handeln der Mathematiker Philosophische Analyse und Betrachtung ihrer Relevanz fr die Industrie

    NASA Astrophysics Data System (ADS)

    Riss, Uwe V.; Schmidt, Vasco A.

    Die grundlegende Frage, mit der wir uns im Folgenden beschftigen wollen, ist, welches die charakteristischen Fhigkeiten von Mathematikern sind und warum diese fr die Industrie interessant erscheinen. Allgemein schreibt das Berufe-Lexikon ber das Berufsbild des Mathematikers: "Mathematiker befassen sich mit der Entwicklung und Weiterentwicklung mathematischer Formeln, Methoden und Theorien und bertragen diese auf praxisbezogene Fragestellungen aus Naturwissenschaften, Medizin, Ingenieur- oder Wirtschaftswissenschaften. Das Berufsbild des Mathematikers variiert sehr stark in Abhngigkeit vom Einsatzfeld. Die meisten Mathematiker bernehmen eine Lehrttigkeit an Schulen oder Hochschulen. Weiterhin arbeiten Mathematiker in Wirtschaftsbranchen, die mathematische Grundstze fr ihre Entscheidungsfindung nutzen. Hervorzuheben sind hier insbesondere Versicherungen, Kreditinstitute, Unternehmensberatungen, Software-Unternehmen und Pharmahersteller."

  7. Nichtlineare Analyse von LC-TANK VCOs unter Bercksichtigung parasitrer Substrateffekte

    NASA Astrophysics Data System (ADS)

    Przytarski, J.; Bremer, J.-K.; Mathis, W.

    2009-05-01

    In dieser Arbeit wird ein Konzept vorgestellt, die Schaltungsarchitektur des LC-Tank-VCOs im hherdimensionalen Zustandsraum zu modellieren. Dabei wurde die VCO-Schaltung auf dominante nichtlineare und asymmetrische Effekte nher untersucht. Das entwickelte Modell bildet die Grundlage fr nachfolgende parameterabhngige Analysen der Oszillatorschaltung mittels der Andronov-Hopf Bifurkationsanalyse. Zu diesem Zweck wurde ein hherdimensionales Modell entwickelt, welches fr die Bifurkationsanalyse auf ein System 2. Ordnung reduziert werden muss. Als mathematisches Hilfsmittel zur Ordnungsreduktion des Systems wird das Verfahren der Zentrumsmannigfaltigkeit verwendet. Das Differentialgleichungssystem wird sehr schaltungsnah aufgestellt, daraus resultiert der Vorteil einer genaueren Reprsentation des physikalischen Verhaltens der Schaltung. Ziel ist es mglichst viele Effekte die sich auf das Verhalten des VCOs auswirken knnen, mit zu bercksichtigen.

  8. 50 CFR 648.92 - Effort-control program for monkfish limited access vessels.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... monkfish DAS, may fish any combination of monkfish, roundfish, and flatfish gillnets, up to 150 nets total, provided that the number of monkfish, roundfish, and flatfish gillnets is consistent with the...

  9. Mol-Gastronomie Ksefondue: eine kolloidale Schmelze

    NASA Astrophysics Data System (ADS)

    Vilgis, Thomas A.

    2004-11-01

    An Weihnachten oder zum Jahreswechsel kommt gern das Fonduegeschirr zum Einsatz, weil sich damit viele hungrige Gste unterhaltsam sttigen lassen. Ksefondues sind allerdings eine physikalisch anspruchsvolle Angelegenheit. Die Kunst besteht darin, die viskoelastische Kseschmelze whrend des Genusses homogen zu halten.

  10. Low cycle fatigue of A356-T6 cast aluminum alloy

    SciTech Connect

    Wigant, C.C.; Stephens, R.I.

    1987-01-01

    Smooth specimen low cycle fatigue behavior of A356-T6 cast aluminum alloy with secondary dendritic arm spacing (DAS) of 36 and 58 ..mu..m was obtained under room temperature test conditions. Under strain-controlled axial fatigue conditions, cyclic strain hardening occurred for both DAS values. Hysteresis loops were skewed from 1 to 13% toward the compression side. At higher strain amplitudes the smaller DAS had slightly better fatigue resistance while at the lower strain amplitudes the fatigue resistance was essentially the same for both DAS values. Many test specimens failed outside the test gage length and were thus considered invalid tests. This large number of invalid tests was attributed to surface and near surface discontinuities.

  11. Die Pugwash Conferences on Science and World Affairs Ein Beispiel für erfolgreiche Track-II-Diplomacy“ der Naturwissenschaftler im Kalten Krieg

    NASA Astrophysics Data System (ADS)

    Neuneck, Gtz

    "Kein Zeitalter der Geschichte ist strker von den Naturwissenschaften durchdrungen und abhngiger von ihnen als das 20. Jahrhundert" schreibt Eric Hobsbawn im Kapitel "Zauberer und Lehrlinge: Die Naturwissenschaften" seines Buches "Zeitalter der Extreme".

  12. Diamantsynthese aus der Gasphase: Werkstoff mit Zukunft

    NASA Astrophysics Data System (ADS)

    Ley, Lothar

    2001-09-01

    Die Natur hat Millionen von Jahren bentigt, um Diamanten wachsen zu lassen. Die moderne Materialwissenschaft stellt in einem Tag ein Diamantfenster aus Wasserstoff und Methan her. Und das taugt nicht nur zum Durchgucken!

  13. Inhibition of aberrant complement activation by a dimer of acetylsalicylic acid.

    PubMed

    Lee, Moonhee; Wathier, Matthew; Love, Jennifer A; McGeer, Edith; McGeer, Patrick L

    2015-10-01

    We here report synthesis for the first time of the acetyl salicylic acid dimer 5,5'-methylenebis(2-acetoxybenzoic acid) (DAS). DAS inhibits aberrant complement activation by selectively blocking factor D of the alternative complement pathway and C9 of the membrane attack complex. We have previously identified aurin tricarboxylic and its oligomers as promising agents in this regard. DAS is much more potent, inhibiting erythrocyte hemolysis by complement-activated serum with an IC50 in the 100-170 nanomolar range. There are numerous conditions where self-damage from the complement system has been implicated in the pathology, including such chronic degenerative diseases of aging as Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, and age-related macular degeneration. Consequently, there is a high priority for the discovery and development of agents that can successfully treat such conditions. DAS holds considerable promise for being such an agent. PMID:26248865

  14. Dysfunctional Attitudes Scale Perfectionism: A Predictor and Partial Mediator of Acute Treatment Outcome among Clinically Depressed Adolescents

    PubMed Central

    Jacobs, Rachel H.; Silva, Susan G.; Reinecke, Mark A.; Curry, John F.; Ginsburg, Golda S.; Kratochvil, Christopher J.; March, John S.

    2009-01-01

    The effect of perfectionism on acute treatment outcomes was explored in a randomized controlled trial of 439 clinically depressed adolescents (1217 years of age) enrolled in the Treatment for Adolescents with Depression Study (TADS) who received cognitive behavior therapy (CBT), fluoxetine, a combination of CBT and FLX, or pill placebo. Measures included the Childrens Depression Rating ScaleRevised, the Suicidal Ideation QuestionnaireGrades 79, and the perfectionism subscale from the Dysfunctional Attitudes Scale (DAS). Predictor results indicate that adolescents with higher versus lower DAS perfectionism scores at baseline, regardless of treatment, continued to demonstrate elevated depression scores across the acute treatment period. In the case of suicidality, DAS perfectionism impeded improvement. Treatment outcomes were partially mediated by the change in DAS perfectionism across the 12-week period. PMID:20183664

  15. Identification of a direct role for mitochondria in the toxicity of ribotoxic stress inducing trichothecenes

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Trichothecenes are protein synthesis inhibitors that trigger a ribotoxic stress response leading to rapid activation of MAPKs, induction of proinflammatory responses, and cell death. These foodborne toxins include deoxynivalenol (DON), diacetoxyscirpenol (DAS), T-2, and trichothecin (Tcin). Identify...

  16. Farbenspiel im Spinnennetz: Spielwiese

    NASA Astrophysics Data System (ADS)

    Schlichting, Hans Joachim

    2004-01-01

    In Spinnennetzen kann man unter gnstigen Bedingungen ein prchtiges Farbenspiel beobachten, das aus physikalischer Sicht hoch interessant ist. Wahrscheinlich hat es seine Ursache in einem Beugungseffekt an den dnnen Spinnenfden und anschlieender Interferenz.

  17. Die Quantenwelt - unbestimmt und nichtlokal?: Interpretation verschrnkter Zustnde

    NASA Astrophysics Data System (ADS)

    Fink, Helmut

    2004-07-01

    Das aufblhende Gebiet der Quanteninformationsverarbeitung belebt die alte Frage, wie das Phnomen der quantenphysikalischen Verschrnktheit zu interpretieren sei. Besonders das berhmte Gedankenexperiment von Einstein, Podolsky und Rosen rckt wieder in das Zentrum der Aufmerksamkeit, seit Laborexperimente an verschrnkten Quantensystemen durchgefhrt werden, deren Teile rumlich weit von einander entfernt sind. Kann ein Teil eines solchen verschrnkten Systems mit berlichtgeschwindigkeit spren, dass an einem weit entfernten anderen Teil gemessen wird? Hinter dieser Frage steckt die Vorstellung, es gebe einen nichtlokalen Mechanismus in der Natur. Diese Vorstellung erweist sich jedoch als keineswegs zwingend und sogar als irrefhrend, wenn man akzeptiert, dass die Werte von Beobachtungsgren in Quantenzustnden objektiv unbestimmt sind. Sie entstehen erst dort, wo wirklich gemessen wird.

  18. The trigger and data acquisition for the NEMO-Phase 2 tower

    SciTech Connect

    Pellegrino, C.; Biagi, S.; Fusco, L. A.; Margiotta, A.; Spurio, M.; Chiarusi, T.; and others

    2014-11-18

    In the framework of the Phase 2 of the NEMO neutrino telescope project, a tower with 32 optical modules is being operated since march 2013. A new scalable Trigger and Data Acquisition System (TriDAS) has been developed and extensively tested with the data from this tower. Adopting the all-data-to-shore concept, the NEMO TriDAS is optimized to deal with a continuous data-stream from off-shore to on-shore with a large bandwidth. The TriDAS consists of four computing layers: (i) data aggregation of isochronal hits from all optical modules; (ii) data filtering by means of concurrent trigger algorithms; (iii) composition of the filtered events into post-trigger files; (iv) persistent data storage. The TriDAS implementation is reported together with a review of dedicated on-line monitoring tools.

  19. 78 FR 70043 - Pesticide Product Registration; Receipt of an Application for a New Active Ingredient

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-22

    ... name: DAS-81419-2 Soybean. Active ingredients: Bacillus thuringiensis Cry1Ac protein expressed in soybean and Bacillus thuringiensis Cry1F protein expressed in soybean. Proposed classification/Use:...

  20. AN INTRODUCTION TO ABHINAVA CHINTAMANI AN AYURVEDA TREATISE FROM ORISSA

    PubMed Central

    Kishore, Prem; Dash, S.; Nanda, M.C.

    1990-01-01

    A synopsis of the Sanskrit text, Abhinava Chintamani is presented in this paper. Attention is paid to highlight the novel features of this text composed in 18th Century A. D. by Mahamati Cakrapani Das of Orissa. PMID:22556512

  1. Craniota, Wirbel- oder Schdeltiere

    NASA Astrophysics Data System (ADS)

    Schultze, Hans-Peter

    Zu den Craniota zhlen alle Chordatiere, die eine dreiteilige Regionalisierung des Krpers in Kopf, Rumpf und Schwanz aufweisen. Der Kopf umfasst (1) das Neurocranium mit Gehirn und komplexen Sinnesorganen zur Wahrnehmung der Umgebung, (2) das Viscerocranium zur Nahrungsaufnahme und zur Ventilation der Kiemen bei den primr wasserlebenden Craniota und (3) das Dermatocranium (S. 38). Letzteres entsteht durch Verkncherungen im Bindegewebe des Integuments, es dient dem Schutz des Kopfes und trgt im Mundbreich die Zhne. Zusammen bilden die drei Skelettstrukturen die funktionelle Einheit Schdel (Cranium). Auer der (somatischen) Rumpfmuskulatur und dem Axialskelett liegen im Rumpf Kreislauf-, Atmungs-, Verdauungs-, Exkretions- und Fortpflanzungsorgane. Der Schwanz, der Abschnitt hinter der Afterffnung, die das Ende der Leibeshhle markiert, dient mit Muskeln und Schwanzflosse der Fortbewegung.

  2. 78 FR 27367 - New England Fishery Management Council; Public Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-10

    ... recommendations for Allowable Biological Catch (ABC); (3) report on the April 30 Plan Development Team (PDT) meeting; (4) provide a presentation outlining DAS/trip limit options developed by the PDT; (5) discuss...

  3. 50 CFR 648.91 - Monkfish regulated mesh areas and restrictions on gear and methods of fishing.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... size for any trawl net, including beam trawl nets, used by a vessel fishing under a monkfish DAS is 10... continuous meshes forward of the terminus of the net. The minimum mesh size for the remainder of the...

  4. Einfluss von Lignin und Ferulasure auf die Fermentation von Maiszellwnden (Influence of lignin and ferulic acid on the fermentation of maize cell walls)

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Ballaststoffe unterliegen im Dickdarm einer teilweisen oder vollstndigen mikrobiellen Fermentation. Das Ausma der Fermentation beeinflusst eine Vielzahl physikochemischer und daraus resultierender physiologischer Eigenschaften der Ballaststoffe (z.B. Wasserbindungs- und Bulkvermgen, Transitzeit, ...

  5. 78 FR 75329 - Submission for OMB Review; Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-11

    ... the FMP pursuant to the Magnuson-Stevens Fishery Conservation and Management Act (MSA). The NE Multispecies Days-at-Sea (DAS) leasing program was implemented in 2004 as a result of Amendment 13 (69 FR...

  6. Application of disturbance analysis methodology to safety related transients in the electrical systems of a nuclear power plant. Report UCLA-ENG-8056

    SciTech Connect

    Guarro, S.; Okrent, D.

    1981-08-01

    The present study tries to address the question of whether or not the computerized on-line procedures known under the name of DAS (Disturbance Analysis System) can be usefully and successfully applied to provide timely diagnostics and operational suggestions during the occurrence of a major electrical transient in the auxiliary systems of a nuclear power plant. The perspective of the study is from the plant-safety point of view. A short definition of DAS methodology features and capabilities is presented. A discussion of some of the problems of a general nature that are encountered in DAS safety-oriented applications are also included. The event insufficient power on both emergency buses, with reference to a particular plant dsign (San Onofre 1), is presented. Some transients that have recently occurred in the power supply systems of operating plants are examined. Whether or not a DAS could have successfully dealt with such occurrences is considered.

  7. AZ-101 Mixer Pump Demonstration Data Acquisition System and Gamma Cart Data Acquisition Control System Software Configuration Management Plan

    SciTech Connect

    WHITE, D.A.

    1999-12-29

    This Software Configuration Management Plan (SCMP) provides the instructions for change control of the AZ1101 Mixer Pump Demonstration Data Acquisition System (DAS) and the Sludge Mobilization Cart (Gamma Cart) Data Acquisition and Control System (DACS).

  8. Real-time data acquisition system for the NASA Langley transonic dynamics tunnel

    NASA Technical Reports Server (NTRS)

    Cole, P. H.

    1979-01-01

    The hardware configuration of the Transonic Dynamics Wind Tunnel Data Acquisition System (DAS) which consists of an analog front end that can process up to 260 channels of data is presented. The DAS also has a multi-channel analog-to-digital subsystem that can process up to 50,000 samples of data per sec, and a digital computer with standard and nonstandard devices, with graphics capability. The software configuration of the DAS and complex hardware/software interfaces are described, which can provide automatic amplifier gain and offset adjustment for each data channel. Finally, a summary of specific DAS applications is given including the real-time processing of dynamic deflection data, unsteady pressure measurements, and flutter and buffet data.

  9. Security analysis and enhancements of an effective biometric-based remote user authentication scheme using smart cards.

    PubMed

    An, Younghwa

    2012-01-01

    Recently, many biometrics-based user authentication schemes using smart cards have been proposed to improve the security weaknesses in user authentication system. In 2011, Das proposed an efficient biometric-based remote user authentication scheme using smart cards that can provide strong authentication and mutual authentication. In this paper, we analyze the security of Das's authentication scheme, and we have shown that Das's authentication scheme is still insecure against the various attacks. Also, we proposed the enhanced scheme to remove these security problems of Das's authentication scheme, even if the secret information stored in the smart card is revealed to an attacker. As a result of security analysis, we can see that the enhanced scheme is secure against the user impersonation attack, the server masquerading attack, the password guessing attack, and the insider attack and provides mutual authentication between the user and the server. PMID:22899887

  10. Lebenszyklusmanagement investiver Produkt-Service Systeme

    NASA Astrophysics Data System (ADS)

    Schweitzer, Eric

    Produkt-Service Systeme (PSS) bestehen im Kern aus einem materiellen Sachprodukt, welches ber die verschiedenen Phasen seiner Nutzung, d. h. seinen Lebenszyklus, zielgerichtet durch verschiedene Serviceprodukte ergnzt wird. Die Gestaltung und Realisierung von PSS finden im erweiterten Wertschpfungsnetzwerk des PSS-Anbieters, welches sowohl das Produktions- als auch das Servicenetzwerk umfasst, statt. Das Produktionsnetzwerk beinhaltet z. B. Lieferanten fr Komponenten und Teile zur Herstellung des Sachproduktkerns. Das Servicenetzwerk besteht i. d. R. aus eigenen Niederlassungen, Vertrags- und/oder Servicepartnern des PSS-Anbieters und ist unter anderem fr die Erbringung der Serviceprodukte zustndig. Aufgrund der Einbindung der Kunden in die Serviceprodukterbringungsprozesse ist insbesondere die PSS-Realisierung durch die langfristige Zusammenarbeit des PSS-Anbieters bzw. seiner Partner im Servicenetzwerk mit seinen industriellen Kunden geprgt.

  11. Gefahr aus dem All. Die Erde im Visier.

    NASA Astrophysics Data System (ADS)

    von Rétyi, A.

    Contents: 1. Geheimnisse des Universums. 2. Aus dem Dunkel des Raumes. 3. Auf Kollisionskurs. 4. Tief in der Kreide - das Sterben der Dinosaurier. 5. Keime aus dem Kosmos. 6. Schattenseiten der Sonne.

  12. Blut

    NASA Astrophysics Data System (ADS)

    Shah-Derler, Brigitte; Wintermantel, Erich; Ha, Suk-Woo

    Das Blut zirkuliert in einem System von Blutgefässen und erfüllt dabei wesentliche Transportaufgaben im Organismus. Hauptfunktionen des Blutes sind die Stoffversorgung und -entsorgung der Zellen (Sauerstoff, CO2, Nährstoffe, Stoffwechselprodukte, etc.), der Transport von Hormonen und die Regulation der Körpertemperatur. Das Blut besteht zu 40-45% aus zellulären Bestandteilen und zu 55-60% aus dem Blutplasma (Abb. 7.1). Die Gesamtmenge beträgt beim erwachsenen Menschen etwa 5 bis 6 Liter, was 7-8% des Körpergewichtes entspricht. Aufgrund seiner zahlreichen Aufgaben wird das Blut als "fliessendes Organ“ bezeichnet. Das Blutplasma besteht zu rund 90 Vol.% aus Wasser und zu 10 Vol.% aus Elektrolyten, gelösten Gasen, Proteinen (Albumine, Globuline) und Stoffwechselprodukten. Die annähernd gleichbleibende Zusammensetzung dieser Blutbestandteile gewährleistet u. a. einen relativ konstanten osmotischen Druck und pH-Wert.

  13. Differential Ability Scales: Profiles of Learning-Disabled Subtypes.

    ERIC Educational Resources Information Center

    McIntosh, David E.; Gridley, Betty E.

    1993-01-01

    Administered Differential Ability Scales (DAS) to 83 children and adolescents with learning disabilities. Identified six subgroups: generalized, high functioning, normal, underachievement, borderline, and dyseidetic. Not all subgroups displayed expected discrepancy between intelligence and achievement associated with current definitions of

  14. A Variable Resolution Stretched Grid Data Assimilation System for Regional Studies and Applications

    NASA Technical Reports Server (NTRS)

    Fox-Rabinovitz, Michael S.; Takacs, Lawrence L.; Dee, Dick P.

    1999-01-01

    The variable resolution stretched grid (SG) version of the Goddard Earth Observing System (GEOS) Data Assimilation System (DAS) incorporating the GEOS SG-GCM, has been developed and tested. The area/region of interest used in experiments is a rectangle over the U.S. with -60 km horizontal resolution and 70 layers extending from the surface to 0.1 hPa. The forecast error statistics has been reassessed for finer regional resolution. The experiments are performed for winter and summer seasons. The SG-GCM and SG-DAS experiments show that a definite down-scaling takes place over the area of interest. The SG-DAS is capable of reproducing regional mesoscale patterns and diagnostics that are not produced by coarser uniform resolution runs. The SG-DAS fields and diagnostics are used for regional forecasting, new instrument impact studies, and for validation of regional climate simulation experiments.

  15. Regional Studies and Applications with a Variable Resolution Stretched Grid Data Assimilation System

    NASA Technical Reports Server (NTRS)

    Fox-Rabinovitz, Michael; Dee, Dick; Takacs, Lawrence

    1999-01-01

    The variable resolution stretched grid (SG) version of the Goddard Earth Observing System (GEOS) Data Assimilation System (DAS) incorporating the GEOS SG-GCM, is used for regional analysis, forecast, and climate applications. The region of interest with enhanced horizontal resolution, mostly used in experiments, is a rectangle over the U.S. The SG-DAS is capable of reproducing regional mesoscale fields, patterns and diagnostics that are not produced by the medium uniform resolution run with the same amount of grid points as for the SG. The SG-DAS regional analyses and diagnostics are used for: validation of regional climate simulation experiments produced with the SG-GCM for the U.S. 1988 summer drought; and are planned to be used for atmospheric chemistry transport experiments. Also, a case study is conducted on a super-typhoon development in December 1997. The SG-DAS appears to be a viable candidate for a variety of regional studies and applications.

  16. Effects of thermal pre-treatment on anaerobic co-digestion of municipal biowastes at high organic loading rate.

    PubMed

    Guo, Jianbin; Wang, Wei; Liu, Xiao; Lian, Songjian; Zheng, Lei

    2014-04-01

    Anaerobic co-digestion of thermal pre-treated municipal biowaste (MBW) is a field of research that has had limited contributions to date. In this study, laboratory-scale semi-continuously fed anaerobic digesters treating thermally treated and non-treated MBW were operated at high organic loading rates (OLR). The results show that the methanogenesis process was inhibited by the accumulated volatile fatty acids when 30% (w/w) of dewatered activated sludge (DAS) was co-digested with food waste (FW) and fruit/vegetable residue (FVR) at high OLR≥10 kg volatile solid m(-3) d(-1). Co-digestion with thermal hydrolysed DAS can significantly improve digester performance. In contrast to DAS, some adverse effects of thermal pretreatment on the biodegradability of FW and FVR were observed. Therefore, co-digestion of FW, FVR with thermally treated DAS is suggested as an alternative to promote high methane production and process stability. PMID:24374189

  17. Systematik der Fahrzeugtechnik

    NASA Astrophysics Data System (ADS)

    Burg, Heinz; Moser, Andreas

    In dem Kraftfahrtechnischen Taschenbuch, das von der Firma Robert Bosch GmbH herausgegeben wird, ist eine Gliederung der Kraftfahrzeuge vorgenommen worden, die international verbreitet und anerkannt ist. Diese Systematik ist nachstehend wiedergegeben und wird in diesem Buch weitgehend verwendet.

  18. Festkrperphysik Teamarbeit im Supraleiter

    NASA Astrophysics Data System (ADS)

    Sparn, Gnter

    2004-05-01

    Magnetismus und Supraleitung galten lange Zeit als gegenstzlich. Die Entdeckung von Supraleitung in einem Metall, das eine dichte Anordnung von magnetischen Ionen enthlt, vernderte dieses Bild Ende der 1970er-Jahre grundlegend.

  19. A pharmacist visit improves diabetes standards in a patient-centered medical home (PCMH).

    PubMed

    Edwards, Heather D; Webb, Ryan D; Scheid, Dewey C; Britton, Mark L; Armor, Becky L

    2012-01-01

    Many patients with diabetes do not receive recommended standards of care. Diabetes patients were seen by a pharmacist in a diabetes assessment service (DAS) 1 week prior to a physician appointment to complete diabetes standards. Completion rates of American Diabetes Association (ADA) standards were compared between patients of 5 physicians offered the DAS intervention and a concurrent cohort of randomly selected patients of nonparticipating physicians. A total of 94 patients were seen by DAS; 210 patients comprised the controls. DAS patients had a significantly higher proportion of each standard completed (glycosylated hemoglobin, lipids, foot exam, eye referral, pneumococcal and influenza vaccination, and urine microalbumin) compared with the control group (P < .001). An average of 3.3 1.8 diabetes standards per patient were completed. A planned visit with a pharmacist prior to a physician appointment, with the goal of completing ADA standards of care, was feasible and effective in this university-based family medicine center. PMID:22679128

  20. Mol-Gastronomie Von Schumen und Trumen

    NASA Astrophysics Data System (ADS)

    Vilgis, Thomas A.

    2005-01-01

    Traumhafte Souffles, kstliches Schokoladenmus, se Meringuen, lockere Biskuits, wem luft bei diesen Kulinarien nicht das Wasser im Munde zusammen. In Abwandlung des Sprichworts erweisen sich solche Schume tatschlich als Trume, jedenfalls zu Tisch.

  1. Potential for Subsidence at the Low-level Waste Disposal Area

    SciTech Connect

    Keck, Karen Nina; Seitz, Roger Ray

    2002-09-01

    U.S. Department of Energy (DOE) Order 435.1, Radioactive Waste Management requires that DOE low-level radioactive waste (LLW) disposal facilities receive a Disposal Authorization Statement (DAS) from DOE-Headquarters. The DAS for the LLW disposal facility at the Radioactive Waste Management Complex (RWMC) at the Idaho National Engineering and Environmental Laboratory (INEEL) was granted in April 2000 and included a number of conditions that must be addressed. A maintenance plan (Schuman 2000) was prepared that identifies the tasks to be completed to address the conditions in the DAS as well as a schedule for their completion. The need for a subsidence analysis was one of the conditions identified for the DAS, and thus, a task to prepare a subsidence analysis was included in the maintenance plan. This document provides the information necessary to satisfy that requirement.

  2. Potential for Subsidence at the Low-Level Radioactive Waste Disposal Area

    SciTech Connect

    Keck, K.A.; Seitz, R.R.

    2002-09-26

    U.S. Department of Energy (DOE) Order 435.1, Radioactive Waste Management requires that DOE low-level radioactive waste (LLW) disposal facilities receive a Disposal Authorization Statement (DAS) from DOE-Headquarters. The DAS for the LLW disposal facility at the Radioactive Waste Management Complex (RWMC) at the Idaho National Engineering and Environmental Laboratory (INEEL) was granted in April 2000 and included a number of conditions that must be addressed. A maintenance plan (Schuman 2000) was prepared that identifies the tasks to be completed to address the conditions in the DAS as well as a schedule for their completion. The need for a subsidence analysis was one of the conditions identified for the DAS, and thus, a task to prepare a subsidence analysis was included in the maintenance plan. This document provides the information necessary to satisfy that requirement.

  3. Wrmestrahlung

    NASA Astrophysics Data System (ADS)

    Heintze, Joachim

    Neben Wrmeleitung und Konvektion gibt es noch eine dritte Art, Wrmeenergie zu bertragen: die Wrmestrahlung. Sie ist fr das Naturgeschehen die wichtigste, vom physikalischen Standpunkt aus gesehen sicher die interessanteste Form des Wrmetransports.

  4. Security Analysis and Enhancements of an Effective Biometric-Based Remote User Authentication Scheme Using Smart Cards

    PubMed Central

    An, Younghwa

    2012-01-01

    Recently, many biometrics-based user authentication schemes using smart cards have been proposed to improve the security weaknesses in user authentication system. In 2011, Das proposed an efficient biometric-based remote user authentication scheme using smart cards that can provide strong authentication and mutual authentication. In this paper, we analyze the security of Das's authentication scheme, and we have shown that Das's authentication scheme is still insecure against the various attacks. Also, we proposed the enhanced scheme to remove these security problems of Das's authentication scheme, even if the secret information stored in the smart card is revealed to an attacker. As a result of security analysis, we can see that the enhanced scheme is secure against the user impersonation attack, the server masquerading attack, the password guessing attack, and the insider attack and provides mutual authentication between the user and the server. PMID:22899887

  5. 76 FR 4683 - Pesticide Experimental Use Permit; Receipt of Application; Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-01-26

    ... Cry35Ab1 proteins and the genetic material necessary for their production (PHP17662 T-DNA) in event... material necessary for their production (PHP17662 T-DNA) in event DAS59122-7 corn (OECD Unique...

  6. Die Paketversicherung von MathPost

    NASA Astrophysics Data System (ADS)

    Daume, Peggy

    Angesichts der fundamentalen Bedeutung des Versicherungsgedankens fr die menschliche Existenz kann das Versicherungswesen auf eine lange Geschichte zurckblicken. Dabei lassen sich zwei Grundformen von Versicherungen unterscheiden, die sich gegenseitig beeinflusst und gegenber anderen Formen durchgesetzt haben.

  7. Using humans to make a human leishmaniasis vaccine.

    PubMed

    Kamhawi, Shaden; Oliveira, Fabiano; Valenzuela, Jesus G

    2014-04-30

    The cellular immune response to peptide pools from conserved Leishmania antigens in leishmaniasis-immune individuals identified epitopes for a human DNA vaccine (Das et al., this issue). PMID:24786322

  8. Modulation of p53 in 7,12-dimethylbenz[a]anthracene-induced skin tumors by diallyl sulfide in Swiss albino mice.

    PubMed

    Arora, Annu; Siddiqui, Imtiaz A; Shukla, Yogeshwer

    2004-11-01

    Allium vegetables have been shown to have beneficial health effects against several chronic diseases including cancer. Diallyl sulfide (DAS), an organosulfur compound present in garlic, is well known for its chemopreventive properties in several tumor models. The pharmacologic role of DAS in prevention and treatment of cancer is well documented in the literature, but its molecular mechanism of action is not yet well defined. In the present study, modulation in p53 expression by topical application of DAS was recorded in 7,12-dimethylbenz[a]anthracene (DMBA)-induced skin tumors in Swiss albino mice. Western blot analysis and immunohistochemical protein detection, combined with multivariable flow cytometry, show that DAS application induces the expression of the wild-type (wt) p53 and down-regulates the expression of mutant (mut) p53. Immunoblotting analysis of tumors showed significant increase in levels of wtp53 by DAS application, whereas for mutp53 the DMBA-induced levels of protein were found to reduce to near normal levels with DAS application. The quantitative analysis of immunostained skin/tumor sections using image analysis and quantitative stereology showed 66.6% and 54.2% increases in wtp53 levels and 53.4% and 44.3% decreases in mutp53 levels in animals where DAS was applied 1 hour prior to or 1 hour after DMBA application, respectively. Flow cytometric analysis further confirmed modulation of wtp53 and mutp53 protein in DAS-supplemented tumors. The increase in the expression of wt tumor suppressor gene protein p53 was accompanied by elevation of the levels of cyclin-dependent kinase inhibitor p21/waf1. The percentage increase in the levels of p21/waf1 was found to be 72.9% and 61.3%, respectively, in DAS-supplemented groups before and after administration. These results thus show that DAS is a potential chemopreventive agent capable of modulating and regulating the tumor suppressor p53 along with its downstream effective molecule, p21/waf1. Thus, DAS can be a potential chemopreventive agent against skin tumor development. PMID:15542785

  9. Improvements to NASA's Debris Assessment Software

    NASA Technical Reports Server (NTRS)

    Opiela, J.; Johnson, Nicholas L.

    2007-01-01

    NASA's Debris Assessment Software (DAS) has been substantially revised and expanded. DAS is designed to assist NASA programs in performing orbital debris assessments, as described in NASA s Guidelines and Assessment Procedures for Limiting Orbital Debris. The extensive upgrade of DAS was undertaken to reflect changes in the debris mitigation guidelines, to incorporate recommendations from DAS users, and to take advantage of recent software capabilities for greater user utility. DAS 2.0 includes an updated environment model and enhanced orbital propagators and reentry-survivability models. The ORDEM96 debris environment model has been replaced by ORDEM2000 in DAS 2.0, which is also designed to accept anticipated revisions to the environment definition. Numerous upgrades have also been applied to the assessment of human casualty potential due to reentering debris. Routines derived from the Object Reentry Survival Analysis Tool, Version 6 (ORSAT 6), determine which objects are assessed to survive reentry, and the resulting risk of human casualty is calculated directly based upon the orbital inclination and a future world population database. When evaluating reentry risks, the user may enter up to 200 unique hardware components for each launched object, in up to four nested levels. This last feature allows the software to more accurately model components that are exposed below the initial breakup altitude. The new DAS 2.0 provides an updated set of tools for users to assess their mission s compliance with the NASA Safety Standard and does so with a clear and easy-to-understand interface. The new native Microsoft Windows graphical user interface (GUI) is a vast improvement over the previous DOS-based interface. In the new version, functions are more-clearly laid out, and the GUI includes the standard Windows-style Help functions. The underlying routines within the DAS code are also improved.

  10. Umsetzung der Unternehmensstrategie mit der Balanced Scorecard

    NASA Astrophysics Data System (ADS)

    Crespo, Isabel; Bergmann, Lars; Portmann, Stefan; Lacker, Thomas; Lacker, Michael; Fleischmann, Jrgen; Koz, Hans

    Die Balanced Scorecard (BSC) ist ein Ansatz zum strategischen Management, der neben der Ausrichtung des Unternehmens auf finanzielle Zielwerte ebenso groes Gewicht auf so genannte weiche Faktoren legt, die den wirtschaftlichen Erfolg eines Unternehmens erst ermglichen. Das entscheidende Merkmal der Balanced Scorecard ist dabei, dass sie ein ausgewogenes System strategischer Ziele herstellt, welches das Unternehmen hinsichtlich der vier Perspektiven Finanzen, Kunden, interne Prozesse und Mitarbeiter und Potenziale strategisch ausrichtet (Kaplan u. Norton 1997).

  11. Joint Confirmatory Factor Analysis of the Differential Ability Scales and the "Woodcock-Johnson Tests of Cognitive Abilities--Third Edition"

    ERIC Educational Resources Information Center

    Sanders, Sarah; McIntosh, David E.; Dunham, Mardis; Rothlisberg, Barbara A.; Finch, Holmes

    2007-01-01

    This study examined the underlying constructs measured by the "Differential Ability Scales" ("DAS"; C.D. Elliott, 1990a) as they relate to the "Cattell-Horn-Carroll (CHC) Theory" (K.S. McGrew, 1997) of cognitive abilities. The "DAS" and "Woodcock-Johnson Tests of Cognitive Abilities" ("WJ-III COG"; R.W.Woodcock, K.S. McGrew, & N. Mather, 2001)

  12. Social Bookmarking am Beispiel BibSonomy

    NASA Astrophysics Data System (ADS)

    Hotho, Andreas; Jschke, Robert; Benz, Dominik; Grahl, Miranda; Krause, Beate; Schmitz, Christoph; Stumme, Gerd

    BibSonomy ist ein kooperatives Verschlagwortungssystem (Social Bookmarking System), betrieben vom Fachgebiet Wissensverarbeitung der Universitt Kassel. Es erlaubt das Speichern und Organisieren von Web-Lesezeichen und Metadaten fr wissenschaftliche Publikationen. In diesem Beitrag beschreiben wir die von BibSonomy bereitgestellte Funktionalitt, die dahinter stehende Architektur sowie das zugrunde liegende Datenmodell. Ferner erlutern wir Anwendungsbeispiele und gehen auf Methoden zur Analyse der in BibSonomy und hnlichen Systemen enthaltenen Daten ein.

  13. Ein Regenbogen ohne Regentropfen: Spielwiese

    NASA Astrophysics Data System (ADS)

    Schlichting, Hans Joachim

    2006-09-01

    Wenn Licht unter geeignetem Winkel auf eine quaderfrmige mit Wasser gefllte Wanne trifft, wirken die Lichtbrechungen beim Eintritt in die Wanne und beim Austritt so zusammen, dass ein bogenfrmiges Band spektral zerlegten Lichts auf einer Projektionswand entsteht. Steht die Wanne mitten auf einem Overheadprojektor, so findet das Licht an allen Seitenflchen hnliche Bedingungen vor. Unter Umstnden sind dann an allen vier Wnden des Raumes Regenbgen zu sehen. Dieses Freihandexperiment, das ohne Aufwand realisiert werden kann, beeindruckt vor allem in groen Rumen.

  14. Permeation of Dopamine Sulfate through the Blood-Brain Barrier

    PubMed Central

    Suominen, Tina; Piepponen, T. Petteri; Kostiainen, Risto

    2015-01-01

    Dopamine sulfate (DA-3- and DA-4-S) have been determined in the human brain, but it is unclear whether they are locally formed in the central nervous system (CNS), or transported into the CNS from peripheral sources. In the current study, permeation of the blood-brain barrier (BBB) by DA-S was studied by injecting 13C6-labelled regioisomers of DA-S (13DA-3-S and 13DA-4-S) and dopamine (DA) subcutaneously (s.c.) in anesthetized rats, then analyzing brain microdialysis and plasma samples by UPLC-MS/MS. The results in the microdialysis samples demonstrated that brain concentrations of 13DA-S regioisomers clearly increased after the s.c. injections. The concentration of DA did not change, indicating the permeation of DA-S through an intact BBB. The analysis of plasma samples, however, showed that DA-S only permeates the BBB to a small extent, as the concentrations in plasma were substantially higher than in the microdialysis samples. The results also showed that the concentrations of DA-3-S were around three times higher than the concentrations of DA-4-S in rat brain, as well as in the plasma samples after the s.c. injections, indicating that DA-3-S and DA-4-S permeate the BBB with similar efficiency. The fate of 13DA-S in brain was followed by monitoring 13C6-labelled DA-S hydrolysis products, i.e. 13DA and its common metabolites; however, no 13C6-labelled products were detected. This suggests that DA-S either permeates through the BBB back to the peripheral circulation or is dissociated or metabolized by unexpected mechanisms. PMID:26207745

  15. Teilchenphysik SESAME - Forschung fr den Frieden

    NASA Astrophysics Data System (ADS)

    Schopper, Herwig

    2002-01-01

    Unter der Schirmherrschaft der UNESCO entsteht in den kommenden Jahren in Jordanien ein internationales Forschungszentrum, dessen wichtigste Forschungsanlage eine Quelle fr Synchrotronstrahlung sein wird. Die SESAME (Synchrotron-Light for Experimental Science and Application in the Middle East) genannte Anlage soll auch dazu beitragen, Vertrauen und Toleranz zwischen Wissenschaftlern und Politikern aus verschiedenen Kulturkreisen und Traditionen zu frdern. Das europische Teilchenlabor CERN diente hier in mancher Hinsicht als Vorbild. Technische Grundlage fr SESAME wird das 1999 stillgelegte Berliner Synchrotron BESSY I sein.

  16. Grundlagen Verbrennungsmotoren

    NASA Astrophysics Data System (ADS)

    Merker, Gnter P.; Schwarz, Christian

    Eine der zentralen Aufgaben der Ingenieurwissenschaften ist die mglichst exakte Beschreibung technischer Prozesse mit dem Ziel, das dynamische Verhalten komplexer Systeme zu verstehen, Gesetzmigkeiten zu erkennen und damit zuverlssige Aussagen ber das knftige Verhalten dieser Systeme zu ermglichen. Im Hinblick auf Verbrennungsmotoren als Antriebssysteme fr Land-, Wasser- und Luftfahrzeuge, fr Dauer- und Notstromaggregate, sowie fr Klima- und Klteanlagen kommt dabei der Gesamtprozessanalyse bzw. -simulation eine besondere Bedeutung zu.

  17. Die nuklearen Anlagen von Hanford (1943-1987) Eine Fallstudie über die Schnittstellen von Physik, Biologie und die US-amerikanische Gesellschaft zur Zeit des Kalten Krieges

    NASA Astrophysics Data System (ADS)

    Macuglia, Daniele

    Die Geschichte des Kalten Krieges eröffnet viele Möglichkeiten, sich näher mit den Schnittstellen von Physik und Biologie während des 20. Jahrhunderts zu befassen. Nicht nur das Unglück in Tschernobyl aus dem Jahr 1986, auch das Beispiel der nuklearen Anlagen in Hanford in den Vereinigten Staaten zeigt die biologischen Folgen von nuklearer Physik.

  18. Mitochondrial Dysfunction Meets Senescence.

    PubMed

    Gallage, Suchira; Gil, Jesús

    2016-03-01

    Cellular senescence and mitochondrial dysfunction are hallmarks of ageing, but until now their relationship has not been clear. Recent work by Wiley et al. shows that mitochondrial defects can cause a distinct senescence phenotype termed MiDAS (mitochondrial dysfunction-associated senescence). MiDAS has a specific secretome that is able to drive some of the aging phenotypes. These findings suggest novel therapeutic opportunities for treating age-related pathologies. PMID:26874922

  19. Diallyl Sulfide: Potential Use in Novel Therapeutic Interventions in Alcohol, Drugs, and Disease Mediated Cellular Toxicity by Targeting Cytochrome P450 2E1.

    PubMed

    Rao, P S S; Midde, Narasimha M; Miller, Duane D; Chauhan, Subhash; Kumar, Anil; Kumar, Santosh

    2015-01-01

    Diallyl sulfide (DAS) and other organosulfur compounds are chief constituents of garlic. These compounds have many health benefits, as they are very efficient in detoxifying natural agents. Therefore, these compounds may be useful for prevention/treatment of cancers. However, DAS has shown appreciable allergic reactions and toxicity, as they can also affect normal cells. Thus their use as in the prevention and treatment of cancer is limited. DAS is a selective inhibitor of cytochrome P450 2E1 (CYP2E1), which is known to metabolize many xenobiotics including alcohol and analgesic drugs in the liver. CYP2E1-mediated alcohol/drug metabolism produce reactive oxygen species and reactive metabolites, which damage DNA, protein, and lipid membranes, subsequently causing liver damage. Several groups have shown that DAS is not only capable of inhibiting alcohol- and drug-mediated cellular toxicities, but also HIV protein- and diabetes-mediated toxicities by selectively inhibiting CYP2E1 in various cell types. However, due to known DAS toxicities, its use as a treatment modality for alcohol/drug- and HIV/diabetes-mediated toxicity have only limited clinical relevance. Therefore, effort is being made to generate DAS analogs, which are potent and selective inhibitor of CYP2E1 and poor substrate of CYP2E1. This review summarizes current advances in the field of DAS, its anticancer properties, role as a CYP2E1 inhibitor, preventing agent of cellular toxicities from alcohol, analgesic drugs, xenobiotics, as well as, from diseases like HIV and diabetes. Finally, this review also provides insights toward developing novel DAS analogues for chemical intervention of many disease conditions by targeting CYP2E1 enzyme. PMID:26264202

  20. Development and operation of a real-time data acquisition system for the NASA, Langley Research Center Differential Absorption Lidar

    NASA Technical Reports Server (NTRS)

    Butler, C.; Kindle, E. C.

    1984-01-01

    The capabilities of the DIAL data acquisition system (DAS) for the remote measurement of atmospheric trace gas concentrations from ground and aircraft platforms were extended through the purchase and integration of other hardware and the implementation of improved software. An operational manual for the current system is presented. Hardware and peripheral device registers are outlined only as an aid in debugging any DAS problems which may arise.

  1. Diallyl Sulfide: Potential Use in Novel Therapeutic Interventions in Alcohol, Drugs, and Disease Mediated Cellular Toxicity by Targeting Cytochrome P450 2E1

    PubMed Central

    Rao, PSS; Midde, Narasimha M; Miller, Duane D.; Chauhan, Subhash; Kumar, Anil; Kumar, Santosh

    2015-01-01

    Diallyl sulfide (DAS) and other organosulfur compounds are chief constituents of garlic. These compounds have many health benefits, as they are very efficient in detoxifying natural agents. Therefore, these compounds may be useful for prevention/treatment of cancers. However, DAS has shown appreciable allergic reactions and toxicity, as they can also affect normal cells. Thus their use as in the prevention and treatment of cancer is limited. DAS is a selective inhibitor of cytochrome P450 2E1 (CYP2E1), which is known to metabolize many xenobiotics including alcohol and analgesic drugs in the liver. CYP2E1-mediated alcohol/drug metabolism produce reactive oxygen species and reactive metabolites, which damage DNA, protein, and lipid membranes, subsequently causing liver damage. Several groups have shown that DAS is not only capable of inhibiting alcohol- and drug-mediated cellular toxicities, but also HIV protein- and diabetes-mediated toxicities by selectively inhibiting CYP2E1 in various cell types. However, due to known DAS toxicities, its use as a treatment modality for alcohol/drug- and HIV/diabetes-mediated toxicity have only limited clinical relevance. Therefore, effort is being made to generate DAS analogs, which are potent and selective inhibitor of CYP2E1 and poor substrate of CYP2E1. This review summarizes current advances in the field of DAS, its anticancer properties, role as a CYP2E1 inhibitor, preventing agent of cellular toxicities from alcohol, analgesic drugs, xenobiotics, as well as, from diseases like HIV and diabetes. Finally, this review also provides insights toward developing novel DAS analogues for chemical intervention of many disease conditions by targeting CYP2E1 enzyme. PMID:26264202

  2. Modeling the World Health Organization Disability Assessment Schedule II using non-parametric item response models.

    PubMed

    Galindo-Garre, Francisca; Hidalgo, María Dolores; Guilera, Georgina; Pino, Oscar; Rojo, J Emilio; Gómez-Benito, Juana

    2015-03-01

    The World Health Organization Disability Assessment Schedule II (WHO-DAS II) is a multidimensional instrument developed for measuring disability. It comprises six domains (getting around, self-care, getting along with others, life activities and participation in society). The main purpose of this paper is the evaluation of the psychometric properties for each domain of the WHO-DAS II with parametric and non-parametric Item Response Theory (IRT) models. A secondary objective is to assess whether the WHO-DAS II items within each domain form a hierarchy of invariantly ordered severity indicators of disability. A sample of 352 patients with a schizophrenia spectrum disorder is used in this study. The 36 items WHO-DAS II was administered during the consultation. Partial Credit and Mokken scale models are used to study the psychometric properties of the questionnaire. The psychometric properties of the WHO-DAS II scale are satisfactory for all the domains. However, we identify a few items that do not discriminate satisfactorily between different levels of disability and cannot be invariantly ordered in the scale. In conclusion the WHO-DAS II can be used to assess overall disability in patients with schizophrenia, but some domains are too general to assess functionality in these patients because they contain items that are not applicable to this pathology. PMID:25524862

  3. Amelioration of ferric nitrilotriacetate-induced hepatotoxicity in Wistar rats by diallylsulfide.

    PubMed

    Ansar, S; Iqbal, M

    2016-03-01

    Garlic contains diallylsulfide (DAS) and other structurally related compounds that are widely believed to be active agents in preventing cancer. This study shows the effect of DAS (a phenolic antioxidant used in foods, cosmetics, and pharmaceutical products : on ferric nitrilotriacetate (Fe-NTA)-induced hepatotoxicity in rats. Male albino rats of Wistar strain weighing 125-150 g were given a single dose of Fe-NTA (9 mg kg(-1) body weight, intraperitoneally) after 1 week of treatment with 100 and 200 mg kg(-1) DAS in corn oil respectively administered through the gavage. Fe-NTA administration led to 2.5-fold increase in the values of both alanine transaminase and aspartate aminotransferase, respectively, and 3.2-fold increase in the activity of lactate dehydrogenase, microsomal lipid peroxidation to approximately 2.0-fold compared to saline-treated control. The activities of glutathione (GSH) and other antioxidant enzymes decreased to a range of 2.2-2.5-fold. These changes were reversed significantly (p < 0.001) in animals receiving a pretreatment of DAS. DAS protected against hepatic lipid peroxidation, hydrogen peroxide generation, preserved GSH levels, and GSH metabolizing enzymes to 60-80% as compared to Fe-NTA alone-treated group. Present data suggest that DAS can ameliorate the toxic effects of Fe-NTA and suppress oxidant-induced tissue injury and hepatotoxicity in rats. PMID:25904316

  4. Drugs of abuse in urban groundwater. A case study: Barcelona.

    NASA Astrophysics Data System (ADS)

    Jurado, A.; Mastroianni, N.; Vazquez-Suñe, E.; Carrera, J.; Tubau, I.; Pujades, E.; Postigo, C.; Lopez de Alda, M.; Barceló, D.

    2012-04-01

    This study is concerned with drugs of abuse (DAs) and their metabolites in urban groundwater at field scale in relation to (1) the spatial distribution of the groundwater samples, (2) the depth of the groundwater sample, (3) the presence of DAs in recharge sources, and (4) the identification of processes affecting the fate of DAs in groundwater. To this end, urban groundwater samples were collected in the city of Barcelona and a total of 21 drugs were analyzed including cocainics, amphetamine-like compounds, opioids, lysergics and cannabinoids and the prescribed drugs benzodiazepines. Overall, the highest groundwater concentrations and the largest number of detected DAs were found in zones basically recharged by a river that receives large amounts of effluents from waste water treatment plants (WWTPs). In contrast, the urbanized areas yielded not only lower concentrations but also a much smaller number of drugs, which suggests a local origin. In fact, cocaine and its metabolite were dominant in more prosperous neighbourhoods, whereas the cheaper (MDMA) was the dominant DA in poorer districts. Concentrations of DAs estimated mainly from the waste water fraction in groundwater samples were consistently higher than the measured ones, suggesting that DAs undergo removal processes in both reducing and oxidizing conditions.

  5. Effective co-delivery of doxorubicin and dasatinib using a PEG-Fmoc nanocarrier for combination cancer chemotherapy.

    PubMed

    Zhang, Peng; Li, Jiang; Ghazwani, Mohammed; Zhao, Wenchen; Huang, Yixian; Zhang, Xiaolan; Venkataramanan, Raman; Li, Song

    2015-10-01

    A simple PEGylated peptidic nanocarrier, PEG5000-lysyl-(?-Fmoc-?-Cbz-lysine)2 (PLFCL), was developed for effective co-delivery of doxorubicin (DOX) and dasatinib (DAS) for combination chemotherapy. Significant synergy of DOX and DAS in inhibition of cancer cell proliferation was demonstrated in various types of cancer cells, including breast, prostate, and colon cancers. Co-encapsulation of the two agents was facilitated by incorporation of 9-Fluorenylmethoxycarbonyl (Fmoc) and carboxybenzyl (Cbz) groups into a nanocarrier for effective carrier-drug interactions. Spherical nanomicelles with a small size of ?30nm were self-assembled by PLFCL. Strong carrier/drug intermolecular ?-? stacking was demonstrated in fluorescence quenching and UV absorption. Fluorescence study showed more effective accumulation of DOX in nuclei of cancer cells following treatment with DOX&DAS/PLFCL in comparison with cells treated with DOX/PLFCL. DOX&DAS/PLFCL micelles were also more effective than other treatments in inhibiting the proliferation and migration of cultured cancer cells. Finally, a superior anti-tumor activity was demonstrated with DOX&DAS/PLFCL. A tumor growth inhibition rate of 95% was achieved at a respective dose of 5mg/kg for DOX and DAS in a murine breast cancer model. Our nanocarrier may represent a simple and effective system that could facilitate clinical translation of this promising multi-agent regimen in combination chemotherapy. PMID:26210177

  6. Protective Effects of Diallyl Sulfide on Ovalbumin-Induced Pulmonary Inflammation of Allergic Asthma Mice by MicroRNA-144, -34a, and -34b/c-Modulated Nrf2 Activation.

    PubMed

    Ho, Cheng-Ying; Lu, Chi-Cheng; Weng, Chia-Jui; Yen, Gow-Chin

    2016-01-13

    Allergic airway disorder is characterized by an increase in the level of reactive oxygen species (ROS). The induction of inflammation and hyperresponsiveness by an allergen was ameliorated by antioxidants in vivo. This study investigated the protective effects and underlying mechanism of diallyl sulfide (DAS) on ovalbumin (OVA)-induced allergic asthma of BALB/c mice. The animals were intraperitoneally sensitized by inhaling OVA to induce chronic airway inflammation. By administering DAS, a decrease of the infiltrated inflammatory cell counts and the levels of IL-4 and IL-10 in bronchoalveolar lavage fluid as well as the OVA-specific immunoglobulin E levels in sera were observed. DAS also effectively inhibited OVA-induced inflammatory cell infiltration and mucus hypersecretion in lung tissue. Several OVA-induced inflammatory factors (ROS, 8-hydroxy-2'-deoxyguanosine, 8-iso-prostaglandin F2α, and NF-κB) were inhibited by DAS. In addition, DAS increased OVA inhalation-reduced levels of Nrf2 activation by regulating microRNA-144, -34a and -34b/c. Together, the pathogenesis of OVA-induced asthma is highly associated with oxidative stress, and DAS may be an effective supplement to alleviate this disease. PMID:26646558

  7. Advances and applications of dynamic-angle spinning nuclear magnetic resonance

    SciTech Connect

    Baltisberger, J.H.

    1993-06-01

    This dissertation describes nuclear magnetic resonance experiments and theory which have been developed to study quadrupolar nuclei (those nuclei with spin greater than one-half) in the solid state. Primarily, the technique of dynamic-angle spinning (DAS) is extensively reviewed and expanded upon in this thesis. Specifically, the improvement in both the resolution (two-dimensional pure-absorptive phase methods and DAS angle choice) and sensitivity (pulse-sequence development), along with effective spinning speed enhancement (again through choice of DAS conditions or alternative multiple pulse schemes) of dynamic-angle spinning experiment was realized with both theory and experimental examples. The application of DAS to new types of nuclei (specifically the {sup 87}Rb and {sup 85}Rb nuclear spins) and materials (specifically amorphous solids) has also greatly expanded the possibilities of the use of DAS to study a larger range of materials. This dissertation is meant to demonstrate both recent advances and applications of the DAS technique, and by no means represents a comprehensive study of any particular chemical problem.

  8. The Role of Disease Activity Score 28 in the Evaluation of Articular Involvement in Systemic Lupus Erythematosus

    PubMed Central

    Massaro, Laura; Pacucci, Viviana Antonella; Cipriano, Enrica; Truglia, Simona; Miranda, Francesca; Alessandri, Cristiano; Valesini, Guido; Conti, Fabrizio

    2014-01-01

    Objectives. To evaluate the application of Disease Activity Score 28 (DAS28) to assess joint involvement in Systemic Lupus Erythematosus (SLE). Methods. Sixty-nine SLE patients, complaining of joint symptoms, and 44 rheumatoid arthritis (RA) patients were enrolled. In SLE patients disease activity was assessed with SLEDAI-2K. DAS28 was calculated in all the patients. Results. Thirty SLE patients (43.5%) showed clinical signs of arthritis. Mean DAS28 was 4.0 1.4, 22 patients (31.9%) had low disease activity, 29 (42.0%) moderate, and 18 (26.1%) high. We dichotomized SLE patients according to the presence (Group 1) or absence (Group 2) of articular involvement according to SLEDAI-2K: 56.3% of the patients of the second group had a moderate/high activity according to DAS28. We compared SLE patients with 44 RA patients (M/F 9/35, mean age 55.6 14.5 years; mean disease duration 140.4 105.6 months). No significant differences were found regarding the values of DAS28 between SLE and RA patients. On the contrary, the values of tender and swollen joint count were significantly higher in RA compared to SLE patients (P = 0.0002 and P = 0.0001, resp.). Conclusions. We suggest the use of the DAS28 in the assessment of joint involvement in SLE patients. PMID:25530992

  9. Interforaminal implant placement in oral cancer patients: during ablative surgery or delayed? A 5-year retrospective study.

    PubMed

    Mizbah, K; Dings, J P; Kaanders, J H A M; van den Hoogen, F J A; Koole, R; Meijer, G J; Merkx, M A W

    2013-05-01

    In a retrospective study, two mandibular prosthetic rehabilitation strategies supported by implants in oral cancer patients were evaluated: implants placed in the non-resected edentulous symphyseal area during ablative surgery (DAS implants); or at a later stage (postponed (P) implants). Medical files of patients from two head-neck oncology groups from 2000 to 2005 were screened for study inclusion. DAS protocol was used in one group and P protocol in the other. After a 5 year follow-up of 261 edentulous patients with oral cancer in the second group, P implants were placed in 27 patients to support an overdenture. Of the 249 edentulous patients in the first group, 82 patients were given an implant supported overdenture using the DAS implant protocol. Regarding implant loss, no statistically significant differences were seen between the DAS and P implants. In the DAS group, more patients benefited from an implant-supported lower overdenture (39 versus 11%, respectively), and they received their overdenture on average 20.0 months sooner (sd=11.01, p<0.001) after ablative surgery. 17.1% of DAS implants and 4.6% of P implants were never loaded due to tumour and patient related factors including unfavourable implant soft tissue, tumour recurrence near the implant, or radiotherapy induced trismus. PMID:23102901

  10. Association of a complement receptor 1 gene variant with baseline erythrocyte sedimentation rate levels in patients starting anti-TNF therapy in a UK rheumatoid arthritis cohort: results from the Biologics in Rheumatoid Arthritis Genetics and Genomics Study Syndicate cohort

    PubMed Central

    Bluett, J; Ibrahim, I; Plant, D; Hyrich, K L; Morgan, A W; Wilson, A G; Isaacs, J D; Gaston, H; Mulherin, D; Price, T; Sheeran, T; Chalam, V; Baskar, S; Emery, P; Morgan, A; Buch, M; Bingham, S; O'Reilly, S; Badcock, L; Regan, M; Ding, T; Deighton, C; Summers, G; Raj, N; Stevens, R; Williams, N; Isaacs, J; Platt, P; Walker, D; Kay, L; Griffiths, B; Ng, W-F; Peterson, P; Lorenzi, A; Foster, H; Friswell, M; Thompson, B; Lee, M; Griffiths, I; Hassell, A; Dawes, P; Dowson, C; Kamath, S; Packham, J; Shadforth, M; Brownfield, Ann; Williams, R; Mukhtyar, C; Harrison, B; Snowden, N; Naz, S; Ledingham, J; Hull, R; McCrae, F; Thomas, A; Min, S Young; Shaban, R; Wong, E; Kelly, C; Heycock, C; Hamilton, J; Saravanan, V; Wilson, G; Bax, D; Dunkley, L; Akil, M; Tattersall, R; Kilding, R; Till, S; Boulton, J; Tait, T; Bukhari, M; Halsey, J; Ottewell, L; Buckley, C; Situnayake, D; Carruthers, D; Grindulis, K; Khatack, F; Elamanchi, S; Raza, K; Filer, A; Jubb, R; Abernathy, R; Plant, M; Pathare, S; Clarke, F; Tuck, S; Fordham, J; Paul, A; Bridges, M; Hakim, A; O'Reilly, D; Rajagopal, V; Bhagat, S; Edwards, C; Prouse, P; Moitra, R; Shawe, D; Bamji, A; Klimiuk, P; Bowden, A; Mitchell, W; Bruce, I; Barton, A; Gorodkin, R; Ho, P; Hyrich, K; Dixon, W; Rai, A; Kitas, G; Erb, N; Klocke, R; Douglas, K; Pace, A; Sandhu, R; Whallett, A; Birrell, F; Allen, M; Chaudhuri, K; Chattopadhyay, C; McHale, J; Jones, A; Gupta, A; Pande, I; Gaywood, I; Lanyon, P; Courtney, P; Doherty, M; Chinoy, H; O'Neill, T; Herrick, A; Jones, A; Cooper, R; Bucknall, R; Marguerie, C; Rigby, S; Dunn, N; Green, S; Al-Ansari, A; Webber, S; Hopkinson, N; Dunne, C; Quilty, B; Szebenyi, B; Green, M; Quinn, M; Isdale, A; Brown, A; Saleem, B; Samanta, A; Sheldon, P; Hassan, W; Francis, J; Kinder, A; Neame, R; Moorthy, A; Al-Allaf, W; Taggart, A; Fairburn, K; McKenna, F; Green, M; Gough, A; Lawson, C; Piper, M; Korendowych, E; Jenkinson, T; Sengupta, R; Bhalla, A; McHugh, N; Bond, Debbie; Luqmani, R; Bowness, B; Wordsworth, P; David, J; Smith, W; Mewar, D; Tunn, E; Nelson, K; Kennedy, T; Nixon, J; Woolf, A; Davis, M; Hutchinson, D; Endean, A; Coady, D; Wright, D; Morley, C; Raftery, G; Bracewell, C; Kidd, L; Abbas, I; Filer, C; Kallarackal, G; Barton, A

    2014-01-01

    Eligibility for anti-tumour necrosis factor (TNF) therapy in most European countries is restricted to severe, active rheumatoid arthritis (RA). The DAS28 score is a marker of disease severity and incorporates one of two inflammatory markers, erythrocyte sedimentation rate (ESR) or C-reactive protein. We aimed to determine the relation between genetic variants known to affect ESR and levels of ESR in patients with active RA. DNA samples were genotyped for four single-nucleotide polymorphisms (SNPs) rs7527798 (CR1L), rs6691117 (CR1), rs10903129 (TMEM57) and rs1043879 (C1orf63). The association between SNPs and baseline ESR, baseline DAS28-ESR, and change in DAS28-ESR was evaluated. Baseline ESR was significantly associated with CR1 rs6691117 genotype (P=0.01). No correlation was identified between baseline DAS28-ESR or change in DAS28-ESR. In conclusion, genetic variation in the gene encoding CR1 may alter ESR levels but not DAS28-ESR, indicating no adjustment for CR1 genotype is required in the assessment of patients with severe active RA. PMID:23856853

  11. Engineering Pichia pastoris for improved NADH regeneration: A novel chassis strain for whole-cell catalysis

    PubMed Central

    Geier, Martina; Brandner, Christoph; Strohmeier, Gernot A; Hall, Mlanie; Hartner, Franz S

    2015-01-01

    Summary Many synthetically useful reactions are catalyzed by cofactor-dependent enzymes. As cofactors represent a major cost factor, methods for efficient cofactor regeneration are required especially for large-scale synthetic applications. In order to generate a novel and efficient host chassis for bioreductions, we engineered the methanol utilization pathway of Pichia pastoris for improved NADH regeneration. By deleting the genes coding for dihydroxyacetone synthase isoform 1 and 2 (DAS1 and DAS2), NADH regeneration via methanol oxidation (dissimilation) was increased significantly. The resulting ?das1 ?das2 strain performed better in butanediol dehydrogenase (BDH1) based whole-cell conversions. While the BDH1 catalyzed acetoin reduction stopped after 2 h reaching ~50% substrate conversion when performed in the wild type strain, full conversion after 6 h was obtained by employing the knock-out strain. These results suggest that the P. pastoris ?das1 ?das2 strain is capable of supplying the actual biocatalyst with the cofactor over a longer reaction period without the over-expression of an additional cofactor regeneration system. Thus, focusing the intrinsic carbon flux of this methylotrophic yeast on methanol oxidation to CO2 represents an efficient and easy-to-use strategy for NADH-dependent whole-cell conversions. At the same time methanol serves as co-solvent, inductor for catalyst and cofactor regeneration pathway expression and source of energy. PMID:26664594

  12. Waste retrieval sluicing system data acquisition system acceptance test report

    SciTech Connect

    Bevins, R.R.

    1998-07-31

    This document describes the test procedure for the Project W-320 Tank C-106 Sluicing Data Acquisition System (W-320 DAS). The Software Test portion will test items identified in the WRSS DAS System Description (SD), HNF-2115. Traceability to HNF-2115 will be via a reference that follows in parenthesis, after the test section title. The Field Test portion will test sensor operability, analog to digital conversion, and alarm setpoints for field instrumentation. The W-320 DAS supplies data to assist thermal modeling of tanks 241-C-106 and 241-AY-102. It is designed to be a central repository for information from sources that would otherwise have to be read, recorded, and integrated manually. Thus, completion of the DAS requires communication with several different data collection devices and output to a usable PC data formats. This test procedure will demonstrate that the DAS functions as required by the project requirements stated in Section 3 of the W-320 DAS System Description, HNF-2115.

  13. Correlation of C-reactive protein haplotypes with serum C-reactive protein level and response to anti-tumor necrosis factor therapy in UK rheumatoid arthritis patients: results from the Biologics in Rheumatoid Arthritis Genetics and Genomics Study Syndicate cohort

    PubMed Central

    2012-01-01

    Introduction In many European countries, restrictions exist around the prescription of anti-tumor necrosis factor (anti-TNF) treatments for rheumatoid arthritis (RA). Eligibility and response to treatment is assessed by using the disease activity score 28 (DAS28) algorithm, which incorporates one of two inflammatory markers, erythrocyte sedimentation rate (ESR) or C-reactive protein (CRP). Although DAS28-CRP provides a more reliable measure of disease activity, functional variants exist within the CRP gene that affect basal CRP production. Therefore, we aimed to determine the relation between functional genetic variants at the CRP gene locus and levels of serum CRP in RA patients, and whether these variants, alone or in combination, are correlated with DAS28-CRP and change in DAS28-CRP after anti-TNF treatment. Methods DNA samples from the Biologics in Rheumatoid Arthritis Genetics and Genomics Study Syndicate (BRAGGSS) were genotyped for rs1205, rs1800947, and rs3091244 by using either TaqMan or the Sequenom MassARRAY iPLEX system. Estimated haplotypes were constructed for each sample by using the expectation maximization algorithm implemented in the haplo.stats package within the R statistical program. CRP values were log transformed, and the association between single nucleotide polymorphisms (SNPs), haplotypes of SNPs and baseline CRP, baseline DAS28-CRP, and change in DAS28-CRP were evaluated by using linear regression in STATA v.10. Results Baseline CRP measurements were available for 599 samples with 442 also having data 6 months after treatment with an anti-TNF. For these 442 samples, the study had > 80% power to detect a clinically meaningful difference of 0.6 DAS28 Units for an allele frequency of 5%. Estimated haplotype frequencies corresponded with previous frequencies reported in the literature. Overall, no significant association was observed between any of the markers investigated and baseline CRP levels. Further, CRP haplotypes did not correlate with baseline CRP (P = 0.593), baseline DAS28-CRP (P = 0.540), or change in DAS28-CRP after treatment with an anti-TNF over a 6-month period (P = 0.302). Conclusions Although CRP genotype may influence baseline CRP levels, in patients with very active disease, no such association was found. This suggests that genetic variation at the CRP locus does not influence DAS28-CRP, which may continue to be used in determining eligibility for and response to anti-TNF treatment, without adjusting for CRP genotype. PMID:23039402

  14. The Canadian Methotrexate and Etanercept Outcome Study: a randomised trial of discontinuing versus continuing methotrexate after 6?months of etanercept and methotrexate therapy in rheumatoid arthritis

    PubMed Central

    Pope, Janet E; Haraoui, Boulos; Thorne, J Carter; Vieira, Andrew; Poulin-Costello, Melanie; Keystone, Edward C

    2014-01-01

    Objective To determine if withdrawing methotrexate (MTX) after 6?months of combination etanercept (ETN)+MTX, in MTX-inadequate responders with active rheumatoid arthritis (RA), is non-inferior to continuing ETN+MTX. Methods Tumour necrosis factor-inhibitor nave RA patients with disease activity score 28 (DAS28)?3.2, swollen joint count?3, despite stable MTX, were treated with ETN+MTX for 6?months, followed by randomisation to either continue ETN+MTX or switch to ETN monotherapy for an additional 18?months. The primary endpoint was change in DAS28 from 6-month randomisation to 12?months. The non-inferiority margin of change in DAS28 was 0.6, with prespecified analyses (DAS28<3.2 vs DAS28?3.2). Results 205 patients were randomised. DAS28 was stable in patients on ETN+MTX and increased slightly in patients on ETN monotherapy from 6 to 12?months. Non-inferiority was not achieved, with an adjusted difference of 0.4 (0.1 to 0.7) between the ETN and the ETN+MTX groups, for the month 612 change in DAS28. However, patients who achieved low disease activity (LDA; DAS28<3.2) at 6?months had a similar disease activity at 12?months, whether on monotherapy or combination therapy (DAS28 change 0.7 ETN vs 0.57 ETN+MTX, p=0.8148). Conversely, for patients who did not reach LDA at 6?months, those on ETN monotherapy had increased disease activity at 12?months, while disease activity continued to decrease for patients on combination therapy, at 12?months (DAS28 change 0.4 ETN vs ?0.4 ETN+MTX, p=0.0023). Conclusions Non-inferiority was not achieved. Withdrawing MTX after 6?months of continuation ETN+MTX in MTX inadequate responders did not yield the same degree of improvement between 6 and 12?months compared with continuing ETN+MTX. Trial Registration ClinicalTrials.gov?NCT00654368. PMID:23979914

  15. A Comparison of the Lower Stratospheric Age-Spectra Derived from a General Circulation Model and Two Data Assimilation Systems

    NASA Technical Reports Server (NTRS)

    Schoeberl, Mark R.; Douglass, Anne R.; Zhu, Zhengxin; Pawson, Steven

    2002-01-01

    We use kinematic and diabatic back trajectory calculations, driven by winds from a general circulation model (GCM) and two different data assimilation systems (DAS), to compute the age spectrum at three latitudes in the lower stratosphere. The age-spectra are compared to chemical transport model (CTM) calculations, and the mean ages from all of these studies are compared to observations. The age spectra computed using the GCM winds show a reasonably isolated tropics in good agreement with observations; however, the age spectra determined from the DAS differ from the GCM spectra. For the DAS diabatic trajectory calculations there is too much exchange between the tropics and mid-latitudes. The age spectrum is thus too broad and the tropical mean age is too old as a result of mixing older mid latitude air with tropical air. Likewise the mid latitude mean age is too young due to the in mixing of tropical air. The DAS kinematic trajectory calculations show excessive vertical dispersion of parcels in addition to excessive exchange between the tropics and mid latitudes. Because air is moved rapidly to the troposphere from the vertical dispersion, the age spectrum is shifted toward the young side. The excessive vertical and meridional dispersion compensate in the kinematic case giving a reasonable tropical mean age. The CTM calculation of the age spectrum using the DAS winds shows the same vertical and meridional dispersive characteristics of the kinematic trajectory calculation. These results suggest that the current DAS products will not give realistic trace gas distributions for long integrations; they also help explain why the extra tropical mean ages determined in a number of previous DAS driven CTM s are too young compared with observations. Finally, we note trajectory-generated age spectra . show significant age anomalies correlated with the seasonal cycles. These anomalies can be linked to year-to-year variations in the tropical heating rate. The anomalies are suppressed in the CTM spectra suggesting that the CTM transport scheme is too diffusive.

  16. Predictors of Change in Bodily Pain in Early Rheumatoid Arthritis: An Inception Cohort Study

    PubMed Central

    McWilliams, Daniel F; Zhang, Weiya; Mansell, Josephine S; Kiely, Patrick D W; Young, Adam; Walsh, David A

    2012-01-01

    Objective To investigate possible predictors for lack of pain improvement after 1 year of treatment for early rheumatoid arthritis (RA). Methods The Early Rheumatoid Arthritis Network (ERAN) database was used for analysis of baseline and 1-year pain data. The ERAN is a hospital-based inception cohort of 1,189 people. Short Form 36 questionnaire bodily pain scores were used to calculate change in pain at 1 year as the outcome. The proportion of the Disease Activity Score in 28 joints (DAS28) attributable to patient-reported components (joint tenderness and visual analog scale score; DAS28-P) at baseline was derived as a predictor. Predictors of less improvement in pain were investigated using adjusted odds ratios (ORadj) generated by logistic regression, adjusting for 14 additional clinical and demographic covariates. Results Greater pain at baseline was associated with sex, high DAS28, worse mental health, and smoking. Most patients with early RA reported incomplete improvement in bodily pain after 1 year. The DAS28-P index did not significantly change in the patients whose disease remained active. Less improvement in pain was predicted by female sex (ORadj 3.41, 95% confidence interval [95% CI] 1.358.64) and a high DAS28-P index at baseline (ORadj for tertiles 2.09, 95% CI 1.243.55). Other conventional RA risk factors did not predict pain changes. Conclusion The factors most likely to predict less improvement in pain in early RA are female sex and a high DAS28-P index. A high DAS28-P index may reflect greater contributions of noninflammatory factors, such as central sensitization, to pain. Strategies in addition to inflammatory disease suppression may be required to adequately treat pain. PMID:22556121

  17. Measuring the Value of Earth Observation Information with the Gravity Research and Climate Experiment (GRACE) Satellite

    NASA Astrophysics Data System (ADS)

    Bernknopf, R.; Kuwayama, Y.; Brookshire, D.; Macauley, M.; Zaitchik, B.; Pesko, S.; Vail, P.

    2014-12-01

    Determining how much to invest in earth observation technology depends in part on the value of information (VOI) that can be derived from the observations. We design a framework and then evaluate the value-in-use of the NASA Gravity Research and Climate Experiment (GRACE) for regional water use and reliability in the presence of drought. As a technology that allows measurement of water storage, the GRACE Data Assimilation System (DAS) provides information that is qualitatively different from that generated by other water data sources. It provides a global, reproducible grid of changes in surface and subsurface water resources on a frequent and regular basis. Major damages from recent events such as the 2012 Midwest drought and the ongoing drought in California motivate the need to understand the VOI from remotely sensed data such as that derived from GRACE DAS. Our conceptual framework models a dynamic risk management problem in agriculture. We base the framework on information from stakeholders and subject experts. The economic case for GRACE DAS involves providing better water availability information. In the model, individuals have a "willingness to pay" (wtp) for GRACE DAS - essentially, wtp is an expression of savings in reduced agricultural input costs and for costs that are influenced by regional policy decisions. Our hypothesis is that improvements in decision making can be achieved with GRACE DAS measurements of water storage relative to data collected from groundwater monitoring wells and soil moisture monitors that would be relied on in the absence of GRACE DAS. The VOI is estimated as a comparison of outcomes. The California wine grape industry has features that allow it to be a good case study and a basis for extrapolation to other economic sectors. We model water use in this sector as a sequential decision highlighting the attributes of GRACE DAS input as information for within-season production decisions as well as for longer-term water reliability.

  18. Chemical Genetic Identification of Glutamine Phosphoribosylpyrophosphate Amidotransferase as the Target for a Novel Bleaching Herbicide in Arabidopsis[W][OA

    PubMed Central

    Walsh, Terence A.; Bauer, Teresa; Neal, Roben; Merlo, Ann Owens; Schmitzer, Paul R.; Hicks, Glenn R.; Honma, Mary; Matsumura, Wendy; Wolff, Karen; Davies, John P.

    2007-01-01

    A novel phenyltriazole acetic acid compound (DAS734) produced bleaching of new growth on a variety of dicotyledonous weeds and was a potent inhibitor of Arabidopsis (Arabidopsis thaliana) seedling growth. The phytotoxic effects of DAS734 on Arabidopsis were completely alleviated by addition of adenine to the growth media. A screen of ethylmethanesulfonate-mutagenized Arabidopsis seedlings recovered seven lines with resistance levels to DAS734 ranging from 5- to 125-fold. Genetic tests determined that all the resistance mutations were dominant and allelic. One mutation was mapped to an interval on chromosome 4 containing At4g34740, which encodes an isoform of glutamine phosphoribosylamidotransferase (AtGPRAT2), the first enzyme of the purine biosynthetic pathway. Sequencing of At4g34740 from the resistant lines showed that all seven contained mutations producing changes in the encoded polypeptide sequence. Two lines with the highest level of resistance (125-fold) contained the mutation R264K. The wild-type and mutant AtGPRAT2 enzymes were cloned and functionally overexpressed in Escherichia coli. Assays of the recombinant enzyme showed that DAS734 was a potent, slow-binding inhibitor of the wild-type enzyme (I50 approximately 0.2 μm), whereas the mutant enzyme R264K was not significantly inhibited by 200 μm DAS734. Another GPRAT isoform in Arabidopsis, AtGPRAT3, was also inhibited by DAS734. This combination of chemical, genetic, and biochemical evidence indicates that the phytotoxicity of DAS734 arises from direct inhibition of GPRAT and establishes its utility as a new and specific chemical genetic probe of plant purine biosynthesis. The effects of this novel GPRAT inhibitor are compared to the phenotypes of known AtGPRAT genetic mutants. PMID:17616508

  19. [Guidelines for the use of biologic therapies in rheumatoid arthritis--December 2006 update].

    PubMed

    2007-01-01

    The authors present the revised version of the Portuguese Society of Rheumatology (SPR) guidelines for the treatment of rheumatoid arthritis (RA) with biological therapies. In these guidelines the criteria for introduction and maintenance of biological therapies were discussed as well as the contra-indications and procedures in case of non-responders. Biological treatment is indicated in RA patients with a disease activity score 28 (DAS 28) superior to 3,2 despite treatment with 20mg/week of methotrexate (MTX) for at least 3 months or, if such treatment is not possible, refractory to 6 months of other conventional disease modifying drug or combination therapy. It is also considered the hypothesis of starting a biological treatment in RA patients treated by the previous regimes with a DAS28 score between 2,6 and 3,2 and a significative functional or radiological worsening. The follow-up should be performed each 3 months. The response criteria, at the end of the first 3 months of treatment, is a decrease of 0,6 in the DAS28 score. After 6 months of treatment response criteria is defined as follows: for those with an initial DAS28 score superior to 5,1, a reduction of the DAS28 score below 4 is required; for those with an initial DAS28 score inferior to 5,1, a reduction of the DAS28 score below 2,6 or between 2,6 and 3,2 without a significative functional or radiological worsening is required. Non-responders, in accordance to the Rheumatologist's clinical opinion, should try a switch to other tumour necrosis factor alpha antagonist or to rituximab. PMID:17450763

  20. Inhibition of DES-induced DNA adducts by diallyl sulfide: implications in liver cancer prevention.

    PubMed

    Green, Mario; Thomas, Ronald; Gued, Lisa; Sadrud-Din, Sakeenah

    2003-01-01

    Diethylstilbesterol (DES) is known to cause cancer in humans and animals. Diallyl sulfide (DAS), a component of garlic, has been shown to prevent various types of cancer, presumably via metabolic modulation. Previously, we have demonstrated that DAS prevents the oxidation and reduction of DES in vitro. We hypothesize that DAS will inhibit the metabolism of DES in vivo thus preventing the formation of DES-induced DNA adducts. To test this hypothesis, five groups of five male Sprague-Dawley rats were treated as follows: the control received 0.5 ml of corn oil daily for four days. The second group received 50 mg/kg DAS daily for four days. The third group received 50 mg/kg DAS daily for four days followed by 150 mg/kg DES on day five. The fourth group received 400 mg/kg DAS on day five followed by 150 mg/kg DES. The fifth group received 150 mg/kg DES on day five. All of the rats were sacrificed on day five, 4 h after DES treatment. DNA was isolated from the liver and analyzed by 32P-post-labeling for DNA adducts. The in vitro study was performed utilizing four reactions described as follows: the control reaction contained 200 microg DNA, microsomes (346 microg protein/ml), and 10 mM DES; no oxidation co-factor (cumen hydroperoxide) was added. The second reaction, a complete oxidation system, contained 200 microg DNA, microsomes (346 microg protein/ml), 30 mM cumen hydroperoxide, and 10 mM DES. The third reaction contained 200 microg DNA, microsomes (346 microg protein/ml), 30 mM cumen hydroperoxide, 50 mM DAS, and 10 mM DES. The fourth reaction contained 200 microg DNA, microsomes (346 microg protein/ml), 30 mM cumen hydroperoxide, 100 mM DAS, and 10 mM DES. All of the in vitro reactions were buffered with 100 mM KPO4 pH 7.4 and incubated for 30 min at 37 degrees C. DNA was extracted and analyzed by 32P-post-labeling. We found that DAS inhibited the formation of DES-induced DNA adducts in a dose-dependent fashion. We have shown that DES-induced DNA adducts were inhibited in rats that received DAS pre-treatment and co-treatment with DES. These results suggest that DAS directly inhibits the metabolism of DES thus preventing the formation of DNA adducts. In addition to directly inhibiting the metabolism of DES, DAS appears to alter the expression of the metabolic machinery such that DES-induced adducts are inhibited. The inhibition of DES-induced DNA adducts by DAS may prevent the initiation of estrogen-induced cancer. PMID:12684656

  1. Application of contrast-enhanced ultrasonography and ultrasonography scores in rheumatoid arthritis

    PubMed Central

    Cai, Xiao-Han; Yang, Shu-Ping; Shen, Hao-Lin; Lin, Li-Qing; Zhong, Rong; Wu, Rui-Ming; Lv, Guo-Rong

    2015-01-01

    Objective: To investigate diagnostic value of ultrasonography scores (US) and contrast-enhanced ultrasonography (CEUS) in evaluating rheumatoid arthritis (RA) activity. Methods: 39 patients with RA were included and the metacarpophalangeal, proximal interphalangeal, wrist, elbow and knee joints of them were examined by high frequency ultrasound. The severe joints and the related indexes (synovial thickness, synovial blood flow, joint effusion and bone erosion) were exposed. Then scores (0~3) were obtained and the sum was calculated. For 12 patients of the 39, 2.4 ml SonoVue was intravenously injected with observation of synovial enhancing. ROIs time-intensity curve (TIC) was obtained and the parameters including area under curve (AUC), peak intensity (PI) and time to peak (TTP) were analyzed. For 39 patients, the relationships among each parameters, ultrasonography scores, DAS28 scores and biochemical examinations (ESR, CRP, RF, anti-CCP) were analyzed. Results: The US were significantly correlated with DAS28 Scores (r=0.823, P<0.01=. The correlation between US and CRP was better than that between DAS28 scores and CRP (rUS =0.692, rDAS28=0.526, P<0.01). The synovial thickness in US were correlated with DAS28 Scores and biochemical examinations (ESR, CRP) (rDAS28=0.852, rESR=0.779, rCRP=0.587, P<0.01. The AUC and PI in CEUS were significantly correlated with US (rAUC=0.832, rPI=0.809, P<0.01=. The correlations among AUC, PI and ESR were better than that between US and ESR (rAUC=0.907, rPI=0.851, rUS=0.836, P<0.01=. The correlations among AUC, PI and CRP were better than that between US and CRP (rAUC=0.855, rPI=0.854, rUS=0.692, P<0.01. Conclusions: US was almost identical with DAS28 Scores and biochemical examinations (ESR, CRP) in diagnosis of RA activity, while CEUS was almost identical with DAS28 Scores and biochemical examinations (ESR, CRP). In diagnosis of RA, US may be better than DAS28 Scores, while CEUS better than US. Both of them were useful for evaluation of RA activity. PMID:26884917

  2. Populao estelar nuclear e extranuclear em galxias Seyfert 2

    NASA Astrophysics Data System (ADS)

    Raimann, D. I.; Storchi-Bergmann, T.; Cid Fernandes, R., Jr.; Delgado, R. M. G.; Schmitt, H.; Heckman, T.; Leitherer, C.

    2003-08-01

    A luz das estrelas foi, historicamente, vista por observadores de AGNs como uma poluio inconveniente. Conseqentemente, a informao contida nas caractersticas estelares foi, durante muito tempo, largamente omitida. Nos primeiros estudos, o mtodo empregado para remover esta contaminao estelar foi represent-la por um template de galxia elptica e subtra-la do espectro observado, restando o puro AGN como um resduo. Hoje sabemos que no to simples representar essa populao. Vrios estudos tm mostrado a presena de formao estelar recente prxima a regio nuclear de galxias Seyfert. Neste trabalho foi revisada a abordagem tradicional, tendo-se focalizado a anlise na luz estelar. Espectros ticos de fenda longa, com alta razo sinal/rudo, foram usados para estudar a variao radial das larguras equivalentes de linhas de absoro e cores do contnuo. Utilizando o mtodo de sntese espectral de populaes estelares, foram estimadas as contribuies de populaes estelares de diferentes idades (e de um contnuo tipo lei de potncia) para a luz integrada das galxias, em 4020A. As principais concluses deste trabalho so: na regio nuclear, mais da metade das galxias Seyfert 2 da amostra (57%) apresenta contribuies das populaes com 100 milhes de anos ou mais jovens superior a 20% do fluxo em 4020A, enquanto que em cerca de 40% delas a componente de 3 milhes de anos (e/ou luz que provem de um ncleo ativo) tem contribuio significativa (maior do que 10%). Estas contribuies em geral decrescem quando se vai para regies mais distantes do centro das galxias, respectivamente 53% e 30% a 1kpc, 40% e 15% a 3kpc do centro das galxias. Estes resultados foram comparados com aqueles obtidos para uma amostra de galxias no ativas de mesmo tipo de Hubble das Seyfert. Em uma anlise inicial nota-se que em geral as galxias Seyfert apresentam contribuies das populaes de 100 milhes de anos maiores do que aquelas encontradas nas galxias no ativas, sugerindo uma ligao entre a formao estelar e a atividade em galxias.

  3. Vibrational and theoretical study of diacetylenic acids

    NASA Astrophysics Data System (ADS)

    Roman, Maciej; Baranska, Malgorzata

    2015-02-01

    Three selected diacetylenic acids (DAs) with side-chains of various length (CH3sbnd (CH2)msbnd Ctbnd Csbnd Ctbnd Csbnd (CH2)nsbnd COOH, where m = 7, 9, 11, and n = 3, 8) were analyzed using vibrational spectroscopy and quantum-chemical calculations. The conformational analysis was followed by potential energy distribution (PED) calculations to gain deeper insight into their FT-Raman and FT-IR spectra. The analysis was focused on spectral features of the diacetylene system sensitive to the substitution. In particular, the electron donor-acceptor properties of the substituent and the influence of side-chain length were studied. FT-IR spectra were measured by using two techniques, i.e. transmission (with KBr substrate) and Attenuated Total Reflection (ATR), and the latter seems to be less adequate for DAs measurements because the bands in the fingerprint region as well as the ?(Ctbnd C)as mode are relatively of low intensity. Additionally, polymerization process of DAs was recognized using FT-Raman spectroscopy and strong and well-separated bands of diacetylenic polymers. Temperature and exposure to the sunlight are the factors of an important influence on the polymerization process of DAs. Since the investigated DAs are carboxylic acids, the interpretation of experimental spectra was performed on the basis of monomer and dimer calculations.

  4. An Inexpensive Co-Intercalated Layered Double Hydroxide Composite with Electron Donor-Acceptor Character for Photoelectrochemical Water Splitting

    PubMed Central

    Zheng, Shufang; Lu, Jun; Yan, Dongpeng; Qin, Yumei; Li, Hailong; Evans, David G.; Duan, Xue

    2015-01-01

    In this paper, the inexpensive 4,4-diaminostilbene-2,2-disulfonate (DAS) and 4,4-dinitro-stilbene-2,2- disulfonate (DNS) anions with arbitrary molar ratios were successfully co-intercalated into Zn2Al-layered double hydroxides (LDHs). The DAS(50%)-DNS/LDHs composite exhibited the broad UV-visible light absorption and fluorescence quenching, which was a direct indication of photo-induced electron transfer (PET) process between the intercalated DAS (donor) and DNS (acceptor) anions. This was confirmed by the matched HOMO/LUMO energy levels alignment of the intercalated DAS and DNS anions, which was also compatible for water splitting. The DAS(50%)-DNS/LDHs composite was fabricated as the photoanode and Pt as the cathode. Under the UV-visible light illumination, the enhanced photo-generated current (4.67 mA/cm2 at 0.8 V vs. SCE) was generated in the external circuit, and the photoelectrochemical water split was realized. Furthermore, this photoelectrochemical water splitting performance had excellent crystalline, electrochemical and optical stability. Therefore, this novel inorganic/organic hybrid photoanode exhibited potential application prospect in photoelectrochemical water splitting. PMID:26174201

  5. Reliability and Validity of the Persian Version of Templer Death Anxiety Scale-Extended in Veterans of Iran–Iraq Warfare

    PubMed Central

    Sharif Nia, Hamid; Ebadi, Abbas; Lehto, Rebecca H; Mousavi, Batool; Peyrovi, Hamid; Chan, Yiong Huak

    2014-01-01

    Objective: The purpose of this study was to determine the validity and reliability of the Persian version of Templer Death Anxiety Scale-Extended (DAS-E) in veterans of Iran–Iraq Warfare. Methods: In this cross-sectional study, 211 male veterans of Iran–Iraq Warfare completed the 51 item DAS-E. Principal components analysis with varimax rotation was used to assess domain structure of the DAS-E. Internal consistency reliability was assessed with Cronbach’s alpha. Test–retest reliability was assessed with intra-class correlation coefficients for absolute agreement for the individual items and domains. Results: The construct validity of the scale was obtained using exploratory factor analysis that showed four factors with Eigen values of greater than 1 (1, 11 items, α = 0.83; 2, 7 items; α = 0.87; 3, 5 items, α = 0.73; and 4, 4 items, α = 0.75). Test–retest and internal consistency (total alpha) was 0.91 and 0.89, respectively. Conclusion: The DAS-E demonstrated suitable validity and reliability among the veterans under study. The factor analysis demonstrated that the DAS-E has a multi-dimensional structure. With consideration of the proper psychometric characteristics, this scale can be used to further research about death anxiety in this population. PMID:25798171

  6. Immuntherapie des Melanoms: Wirksamkeit und Wirkungsmechanismen.

    PubMed

    Wieder, Thomas; Brenner, Ellen; Braumller, Heidi; Rcken, Martin

    2016-01-01

    Die Erkenntnisse aus 40 Jahren Forschung erlauben es, durch Antikrper-vermittelte Aktivierung des Immunsystems eine therapeutisch wirksame Antitumorantwort zu induzieren. Die "Immun-Checkpoint-Inhibitoren" sind gegen immuninhibitorische Molekle wie cytotoxic Tlymphocyte antigen 4 (CTLA4), programmed-death-1 (PD-1) oder programmed-death-ligand-1 (PD-L1) gerichtet. Die Unterbrechung der PD-1/PD-L1-Interaktion verbessert mittelfristig auch die Prognose bei Patienten mit Melanomen im StadiumIV. So sind unter Therapie mit Anti-PD-1-Antikrpern 30-60% dieser Patienten nach eineinhalb Jahren am Leben. Antitumorale Immuntherapien verursachen nur selten eine vollstndige Zerstrung der Metastasen, sondern eine Regression um 20-80%. Fest etabliert ist, dass das Immunsystem Tumorzellen abtten kann; dies wurde auch fr Immuntherapien belegt. Prklinische Daten zeigten jedoch, dass Immunantworten Tumoren nicht nur tten knnen. So kann das Immunsystem ber die Zytokine Interferon-? und Tumornekrosefaktor in Tumoren einen stabilen Wachstumsarrest hervorrufen, der Seneszenz genannt wird. Ein Ziel antitumoraler Immuntherapien wird also darin liegen, das berleben der Patienten durch eine langfristige Stabilisierung der Metastasen zu sichern. Dies gilt fr das Melanom und das nichtkleinzellige Lungenkarzinom. Sobald Immuntherapien auch bei hufigen Tumoren indiziert sein werden, mssen die Medikamentenpreise deutlich fallen, um sie weiterhin jenen zur Verfgung stellen zu knnen, die die Therapien bentigen. PMID:26713632

  7. Components of the endocannabinoid and dopamine systems are dysregulated in Huntington's disease: analysis of publicly available microarray datasets

    PubMed Central

    Laprairie, Robert B; Bagher, Amina M; Precious, Sophie V; Denovan-Wright, Eileen M

    2015-01-01

    The endocannabinoid system (ECS) and the dopaminergic system (DAS) are two major regulators of basal ganglia function. During Huntington's disease (HD) pathogenesis, the expression of genes in both the ECS and DAS is dysregulated. The purpose of this study was to determine the changes that were consistently observed in the ECS and DAS during HD progression in the central nervous system (CNS) and in the periphery in different models of HD and human HD tissue. To do this, we conducted a meta-analysis of differential gene expression in the ECS and DAS using publicly available microarray data. The consolidated data were summarized as observed changes in gene expression (OCGE) using a weighted sum for each gene. In addition, consolidated data were compared to previously published studies that were not available in the gene expression omnibus (GEO) database. The resulting data confirm gene expression changes observed using different approaches and provide novel insights into the consistency between changes observed in human tissue and various models, as well as disease stage- and tissue-specific transcriptional dysregulation in HD. The major implication of the systems-wide data presented here is that therapeutic strategies targeting the ECS or DAS must consider the dynamic changes in gene expression over time and in different body areas, which occur during HD progression and the interconnectedness of the two systems. PMID:25692022

  8. A Low Cost Concept for Data Acquisition Systems Applied to Decentralized Renewable Energy Plants

    PubMed Central

    Jucá, Sandro C. S.; Carvalho, Paulo C. M.; Brito, Fábio T.

    2011-01-01

    The present paper describes experiences of the use of monitoring and data acquisition systems (DAS) and proposes a new concept of a low cost DAS applied to decentralized renewable energy (RE) plants with an USB interface. The use of such systems contributes to disseminate these plants, recognizing in real time local energy resources, monitoring energy conversion efficiency and sending information concerning failures. These aspects are important, mainly for developing countries, where decentralized power plants based on renewable sources are in some cases the best option for supplying electricity to rural areas. Nevertheless, the cost of commercial DAS is still a barrier for a greater dissemination of such systems in developing countries. The proposed USB based DAS presents a new dual clock operation philosophy, in which the acquisition system contains two clock sources for parallel information processing from different communication protocols. To ensure the low cost of the DAS and to promote the dissemination of this technology in developing countries, the proposed data acquisition firmware and the software for USB microcontrollers programming is a free and open source software, executable in the Linux and Windows® operating systems. PMID:22346600

  9. ROS scavenging system, osmotic maintenance, pigment and growth status of Panicum sumatrense roth. Under drought stress.

    PubMed

    Ajithkumar, I Paul; Panneerselvam, R

    2014-04-01

    Drought stress is one of the abiotic stresses and it may alter plant growth, metabolism and yield. The present study aims to analyze the growth, chlorophyll pigments, osmotic adjustment and antioxidative enzymes activity in Panicum sumatrense under drought stress. The control was irrigated daily and treated plants were irrigated at 4-, 7-, 10-, 13-day intervals. Later, they were irrigated at 3-day interval up to 70 DAS. The root and leaf samples were collected on 30 DAS, 50 DAS and 70 DAS and used for analysis. The root length increased gradually in all drought treatments at all growth stages of P. sumatrense. The chlorophyll pigments and plant height showed a reduction in 13 DID treatment when compared to all treatment. Compatible solutes like proline, glycine betaine and free amino acid increased in all drought treatment when compared to control at 70 DAS. Furthermore, stress treatment caused an increase in activity of antioxidant enzymes like superoxide dismutase, catalase and peroxidase. Panicum sumatrense possess many growth and physiological drought tolerance characters which can be used in future breeding program. PMID:24068516

  10. An Inexpensive Co-Intercalated Layered Double Hydroxide Composite with Electron Donor-Acceptor Character for Photoelectrochemical Water Splitting

    NASA Astrophysics Data System (ADS)

    Zheng, Shufang; Lu, Jun; Yan, Dongpeng; Qin, Yumei; Li, Hailong; Evans, David G.; Duan, Xue

    2015-07-01

    In this paper, the inexpensive 4,4-diaminostilbene-2,2-disulfonate (DAS) and 4,4-dinitro-stilbene-2,2- disulfonate (DNS) anions with arbitrary molar ratios were successfully co-intercalated into Zn2Al-layered double hydroxides (LDHs). The DAS(50%)-DNS/LDHs composite exhibited the broad UV-visible light absorption and fluorescence quenching, which was a direct indication of photo-induced electron transfer (PET) process between the intercalated DAS (donor) and DNS (acceptor) anions. This was confirmed by the matched HOMO/LUMO energy levels alignment of the intercalated DAS and DNS anions, which was also compatible for water splitting. The DAS(50%)-DNS/LDHs composite was fabricated as the photoanode and Pt as the cathode. Under the UV-visible light illumination, the enhanced photo-generated current (4.67 mA/cm2 at 0.8 V vs. SCE) was generated in the external circuit, and the photoelectrochemical water split was realized. Furthermore, this photoelectrochemical water splitting performance had excellent crystalline, electrochemical and optical stability. Therefore, this novel inorganic/organic hybrid photoanode exhibited potential application prospect in photoelectrochemical water splitting.

  11. An Inexpensive Co-Intercalated Layered Double Hydroxide Composite with Electron Donor-Acceptor Character for Photoelectrochemical Water Splitting.

    PubMed

    Zheng, Shufang; Lu, Jun; Yan, Dongpeng; Qin, Yumei; Li, Hailong; Evans, David G; Duan, Xue

    2015-01-01

    In this paper, the inexpensive 4,4-diaminostilbene-2,2-disulfonate (DAS) and 4,4-dinitro-stilbene-2,2- disulfonate (DNS) anions with arbitrary molar ratios were successfully co-intercalated into Zn2Al-layered double hydroxides (LDHs). The DAS(50%)-DNS/LDHs composite exhibited the broad UV-visible light absorption and fluorescence quenching, which was a direct indication of photo-induced electron transfer (PET) process between the intercalated DAS (donor) and DNS (acceptor) anions. This was confirmed by the matched HOMO/LUMO energy levels alignment of the intercalated DAS and DNS anions, which was also compatible for water splitting. The DAS(50%)-DNS/LDHs composite was fabricated as the photoanode and Pt as the cathode. Under the UV-visible light illumination, the enhanced photo-generated current (4.67 mA/cm(2) at 0.8 V vs. SCE) was generated in the external circuit, and the photoelectrochemical water split was realized. Furthermore, this photoelectrochemical water splitting performance had excellent crystalline, electrochemical and optical stability. Therefore, this novel inorganic/organic hybrid photoanode exhibited potential application prospect in photoelectrochemical water splitting. PMID:26174201

  12. Propriedades fsicas de condensaes densas no Escorpio

    NASA Astrophysics Data System (ADS)

    Vilas-Boas, J. W. S.; Barbosa, P. R., Jr.; Hickel, G. R.

    2003-08-01

    O conhecimento das propriedade fsicas das condensaes das nuvens escuras e sua relao com a dinmica das nvens um dos caminhos para o entendimento dos mecanismos de formao de estrelas de massas pequenas. Nesse trabalho, 8 condensaes da nuvem escura do Escorpio foram observadas atravs de transies das molculas de 13CO, C18O e NH3, utilizando-se os radiotelescopios de 15 m do SEST e 64 m de PARKES. Embora localizadas na superfcie de uma bolha com velocidade de expanso entre 12 km/s e 15 km/s (Vilas-Boas et al), as linhas de monxido de carbono apresentaram caractersticas tpicas daquelas observadas em nuvens escuras. Em apenas uma condensao, contendo um objeto Pre-Sequncia Principal (PMS), foi detectada emisso da molcula de amnia. A comparao direta entre as propriedades dessas condensaes densas (ncleos) e aquelas identificadas na Musca, que se caracteriza por ser uma nvem de baixa atividade de formao estelar, mostra que elas tm propriedades idnticas e que as eficincias de formao estelar nos ncleos de ambas as nuvens so similares.

  13. Vibrational and theoretical study of diacetylenic acids.

    PubMed

    Roman, Maciej; Baranska, Malgorzata

    2015-02-25

    Three selected diacetylenic acids (DAs) with side-chains of various length (CH3-(CH2)m-C?C-C?C(CH2)n-COOH, where m=7, 9, 11, and n=3, 8) were analyzed using vibrational spectroscopy and quantum-chemical calculations. The conformational analysis was followed by potential energy distribution (PED) calculations to gain deeper insight into their FT-Raman and FT-IR spectra. The analysis was focused on spectral features of the diacetylene system sensitive to the substitution. In particular, the electron donor-acceptor properties of the substituent and the influence of side-chain length were studied. FT-IR spectra were measured by using two techniques, i.e. transmission (with KBr substrate) and Attenuated Total Reflection (ATR), and the latter seems to be less adequate for DAs measurements because the bands in the fingerprint region as well as the ?(C?C)as mode are relatively of low intensity. Additionally, polymerization process of DAs was recognized using FT-Raman spectroscopy and strong and well-separated bands of diacetylenic polymers. Temperature and exposure to the sunlight are the factors of an important influence on the polymerization process of DAs. Since the investigated DAs are carboxylic acids, the interpretation of experimental spectra was performed on the basis of monomer and dimer calculations. PMID:25244298

  14. Reasons and Determinants for Perceiving Unmet Needs for Mental Health in Primary Care in Quebec

    PubMed Central

    Dezetter, Anne; Duhoux, Arnaud; Menear, Matthew; Roberge, Pasquale; Chartrand, Elise; Fournier, Louise

    2015-01-01

    Objective: To evaluate the mental health care needs perceived as unmet by adults in Quebec who had experienced depressive and (or) anxious symptomatology (DAS) in the previous 2 years and who used primary care services, and to identify the reasons associated with different types of unmet needs for care (UNCs) and the determinants of reporting UNCs. Method: Longitudinal data from the Dialogue Project were used. The sample consisted of 1288 adults who presented a common mental disorder and who consulted a general practitioner. The Hospital Anxiety and Depression Scale was used to measure DAS, and the Perceived Need for Care Questionnaire facilitated the assessment of the different types of UNCs and their motives. Results: About 40% of the participants perceived UNCs. Psychotherapy, help to improve ability to work, as well as general information on mental health and services were the most mentioned UNCs. The main reasons associated with reporting UNCs for psychotherapy and psychosocial interventions are couldnt afford to pay and didnt know how or where to get help, respectively. The factors associated with mentioning UNCs (compared with met needs) are to present a high DAS or a DAS that increased during the past 12 months, to perceive oneself as poor or to not have private health insurance. Conclusions: To reduce the UNCs and, further, to reduce DAS, it is necessary to improve the availability and affordability of psychotherapy and psychosocial intervention services, and to inform users on the types of services available and how to access them. PMID:26175326

  15. Intracellular localization of the Fanconi anemia complementation group A protein.

    PubMed

    Walsh, C E; Yountz, M R; Simpson, D A

    1999-06-16

    Mutations in the Fanconi anemia (FA) complementation group A (FANCA) gene leads to bone marrow failure, developmental abnormalities and cancer predisposition. To map the intracellular site of FANCA, we constructed a plasmid vector which linked in-frame the enhanced green fluorescent protein (EGFP cDNA) to the 5' end of the FANCA cDNA (pDAS-3). We studied the expression of pDAS-3 in the FANCA mutant fibroblast cell line (GM6914). MMC sensitivity of pDAS-3 transfected cells was comparable to wild-type fibroblasts. The resulting fluorescence pattern in the stable pDAS-3 cell line expressing the fusion protein was primarily nuclear. EGFP-selected cells (lacking FANCA) remain hypersensitive to MMC and maintained a cytoplasmic fluorescence pattern. Using deletion mutants of pDAS-3, a nuclear localization domain was identified at the amino terminus of the polypeptide. Western blot results of FANCA protein confirmed the presence of FANCA in nuclear fractions and FANCA protein levels did not vary during cell cycling. This nuclear trafficking of FANCA should guide future work in defining the function of this protein. PMID:10364463

  16. Portuguese guidelines for the use of biological agents in rheumatoid arthritis - March 2010 update.

    PubMed

    Fonseca, Joo Eurico; Canho, Helena; Reis, Paulo; Santos, Maria Jos; Branco, Jaime; Quintal, Alberto; Malcata, Armando; Arajo, Domingos; Ventura, Francisco; Figueiredo, Guilherme; da Silva, Jos Canas; Patto, Jos Vaz; de Queiroz, Mrio Viana; Santos, Rui Andr; Neto, Adriano Jos; de Matos, Alves de; Rodrigues, Ana; Mouro, Ana Filipa; Ribeiro, Ana Sofia; Cravo, Ana Rita; Barcelos, Anabela; Cardoso, Anabela; Vilar, Antnio; Braa, Arecili; Faustino, Augusto; Silva, Candida; Godinho, Ftima; Cunha, Ins; Costa, Jos Antnio; Gomes, Jos Antnio Melo; Pinto, Jos Antnio Arajo; da Silva, J A Pereira; Miranda, Lus Cunha; Ins, Lus; Santos, Lus Maurcio; Cruz, Margarida; Salvador, Maria Joo; Ferreira, Maria Jlia; Rial, Maria; Bernardes, Miguel; Bogas, Mnica; Arajo, Paula; Machado, Pedro; Pinto, Patrcia; de Melo, Rui Gomes; Cortes, Sara; Alcino, Srgio; Capela, Susana

    2010-01-01

    The authors present the revised version of the Portuguese Society of Rheumatology (SPR) guidelines for the treatment of rheumatoid arthritis (RA) with biological therapies. In these guidelines the criteria for introduction and maintenance of biological agents are discussed as well as the contraindications and procedures in the case of non-responders. Biological treatment should be considered in RA patients with a disease activity score 28 (DAS 28) superior to 3.2 despite treatment with 20mg/week of methotrexate (MTX) for at least 3 months or, if such treatment is not possible, after 6 months of other conventional disease modifying drug or combination therapy. A DAS 28 score between 2.6 and 3.2 with a significant functional or radiological deterioration under treatment with conventional regimens could also constitute an indication for biological treatment. The treatment goal should be remission or, if that is not achievable, at least a low disease activity, characterized by a DAS28 lower than 3.2, without significative functional or radiological worsening. The response criteria, at the end of the first 3 months of treatment, are a decrease of 0.6 in the DAS28 score. After 6 months of treatment response criteria is defined as a decrease of more than 1.2 in the DAS28 score. Non-responders, in accordance to the Rheumatologist's clinical opinion, should try a switch to another biological agent (tumour necrosis factor antagonist, abatacept, rituximab or tocilizumab). PMID:20505635

  17. The planning and implementation of a demand-side management/distribution automation system at Taiwan Power Company

    SciTech Connect

    Liu, S.S.; Chen, Yun-Wu

    1994-12-31

    This paper would describe the Taipower`s experience of DSM/DAS development. For the past 5 years, the demand of electricity has maintained a high annual growth rate of 8.45% due to economic prosperity in Taiwan. As the environmental protection consciousness has recently made Taipower difficult to develope and construct new power plants, substations, transmission and distribution lines, and our power grid is an independent system, we do need to concern how to do DSM to manage the load problems. Since 1984, Taipower has established two pilot systems and these systems performed the functions of fault detect and isolation certainly good for Distribution Automation. With the rapid development of computer, communication and control technology, the concept of the DAS has gradually been implemented in real cases. Taipower organized an engineering task group to study DAS several years ago, and based on the operation experience of the existing systems, today Taipower is planning to launch a new DAS project for Tai-Chung area. According to Taipower requirements, the DAS will have the functions of feeder automation, automatic meter reading, load management and disteibution system analysis.

  18. First International Diagnosis Competition - DXC'09

    NASA Technical Reports Server (NTRS)

    Kurtoglu, tolga; Narasimhan, Sriram; Poll, Scott; Garcia, David; Kuhn, Lukas; deKleer, Johan; vanGemund, Arjan; Feldman, Alexander

    2009-01-01

    A framework to compare and evaluate diagnosis algorithms (DAs) has been created jointly by NASA Ames Research Center and PARC. In this paper, we present the first concrete implementation of this framework as a competition called DXC 09. The goal of this competition was to evaluate and compare DAs in a common platform and to determine a winner based on diagnosis results. 12 DAs (model-based and otherwise) competed in this first year of the competition in 3 tracks that included industrial and synthetic systems. Specifically, the participants provided algorithms that communicated with the run-time architecture to receive scenario data and return diagnostic results. These algorithms were run on extended scenario data sets (different from sample set) to compute a set of pre-defined metrics. A ranking scheme based on weighted metrics was used to declare winners. This paper presents the systems used in DXC 09, description of faults and data sets, a listing of participating DAs, the metrics and results computed from running the DAs, and a superficial analysis of the results.

  19. Running the Sloan Digital Sky Survey data archive server

    SciTech Connect

    Neilsen, Eric H., Jr.; Stoughton, Chris; /Fermilab

    2006-11-01

    The Sloan Digital Sky Survey (SDSS) Data Archive Server (DAS) provides public access to over 12Tb of data in 17 million files produced by the SDSS data reduction pipeline. Many tasks which seem trivial when serving smaller, less complex data sets present challenges when serving data of this volume and technical complexity. The included output files should be chosen to support as much science as possible from publicly released data, and only publicly released data. Users must have the resources needed to read and interpret the data correctly. Server administrators must generate new data releases at regular intervals, monitor usage, quickly recover from hardware failures, and monitor the data served by the DAS both for contents and corruption. We discuss these challenges, describe tools we use to administer and support the DAS, and discuss future development plans.

  20. Action of a mycotoxin (diacetoxyscirpenol) on the immune response of the mouse--interaction with an immunomodulator (OM-89).

    PubMed

    Bottex, C; Martin, A; Fontanges, R

    1990-01-01

    The action of diacetoxyscirpenol (DAS)--a mycotoxin that belongs to the family of trichothecenes--on the immune system of the mouse was investigated. Two experimental models were used: 1) bacterial infection with Salmonella typhimurium and 2) the PFC (plaque-forming cells) test on the splenic lymphocytes of the mouse. The results obtained showed that these were dependent on the chronological order of the administration of DAS. When the toxin was administered after a bacterial infection or antigenic stimulation, it was observed an increase in the mortality rate and a very significant decrease in the antibody response. By contrast, when this mycotoxin was administered before the bacterial infection or antigenic stimulation, the results obtained were close to those from the controls. The importance of the administration of an immunomodulator of bacterial origin OM-89 before the immunodepression with DAS was shown. PMID:2229926

  1. LIHE Spectral Dynamics and Jaguar Data Acquisition System Measurement Assurance Results 2014.

    SciTech Connect

    Covert, Timothy T.; Willis, Michael David; Radtke, Gregg Arthur

    2015-06-01

    The Light Initiated High Explosive (LIHE) facility performs high rigor, high consequence impulse testing for the nuclear weapons (NW) community. To support the facility mission, LIHE's extensive data acquisition system (DAS) is comprised of several discrete components as well as a fully integrated system. Due to the high consequence and high rigor of the testing performed at LIHE, a measurement assurance plan (MAP) was developed in collaboration with NW system customers to meet their data quality needs and to provide assurance of the robustness of the LIHE DAS. While individual components of the DAS have been calibrated by the SNL Primary Standards Laboratory (PSL), the integrated nature of this complex system requires verification of the complete system, from end-to-end. This measurement assurance plan (MAP) report documents the results of verification and validation procedures used to ensure that the data quality meets customer requirements.

  2. Ejnar Hertzsprung

    NASA Astrophysics Data System (ADS)

    Herrmann, Dieter B.

    Mit diesem Werk von D.B. Herrmann, dem bekannten Astronomiehistoriker und Direktor der Archenhold-Sternwarte und des Zeiss-Groplanetariums in Berlin, liegt zum ersten Mal eine umfassende Biographie des groen Astronomen Ejnar Hertzsprung vor. Ejnar Hertzsprung (1873-1967) verdanken wir die Entdeckung der Riesen- und Zwergsterne, Grundlage fr das sog. Hertzsprung-Russel-Diagramm, das eine zentrale Rolle bei der Erforschung der Sternentwicklung spielt. Er bearbeitete erfolgreich Doppelsterne und Vernderliche Sterne und trug Entscheidendes zur modernen Astrophysik bei. Wenig bekannt ist sein Leben, das hier unter Benutzung von Arbeitsmaterial, Interviews mit Zeitgenossen, des Familienarchivs und von Sekundrliteratur von einem kundigen Fachmann beschrieben wird. In D.B. Herrmanns Buch wird nicht nur Persnlichkeit und Werk von Hertzsprung lebendig, sondern auch die astronomische Forschung seiner Zeit. Dieser wertvolle Beitrag zur Wissenschaftsgeschichte wendet sich auch an eine breite allgemeine Leserschaft.

  3. Uber Phosphorylierung im Licht

    PubMed Central

    Warburg, Otto

    1962-01-01

    Whrend bisher der Zusammenhang zwischen Dehydrierung und Phosphorylierung im Licht nur fr die stchiometrischen Chinonreactionen bewiesen worden war, ist nunmehr auch fr die katalytischen Chinonreactionen, die aeroben wie die anaeroben, gezeigt worden, dass die Dehydrierung die Phosphorylierung bewirkt. Eine andere Phosphorylierung, als die Phosphorylierung durch Dehydrierung gibt es in den grnen Grana nicht. Natrlich entsteht nunmehr die Frage, welche Substanz das Substrat von Dehydrierung und Phosphorylierung ist. Da die Grana keine Dunkelatmung haben und deshalb im Dunkeln nicht phosphorylieren knnen, auch nicht nach Zusatz von Chinon, so muss das gesuchte Substrat im Licht entstehen; und da der Photolyt der Granareactionen eine Kohlensureverbindung ist, so muss das gesuchte Substrat eine im Licht entstehende Kohlenstoffverbindung sein. Wegen der Grungen und dem einzigen bisher bekannten chemischen Mechanismus der Phosphorylierung durch Dehydrierung (4) denkt man an Triosephosphat. Aber chemisch ist jeder Aldehyd mglich. PMID:14004907

  4. Campus Single Sign-On und hochschulübergreifendes Identity Management

    NASA Astrophysics Data System (ADS)

    Hommel, Wolfgang

    Das im Rahmen von IntegraTUM für die TUM geschaffene Identity & Access Management System setzt das Paradigma unified login um, d. h. ein Benutzer kann alle für ihn relevanten Dienste innerhalb der Hochschule mit derselben Loginname-/Passwortkombination nutzen. Dieser Artikel zeigt, wie auf Basis der Software Shibboleth und der deutschlandweiten Hochschulföderation DFN-AAI als weitere Mehrwerte das campusweite web single sign-on und die nahtlose Nutzung zahlreicher externer Web-Anwendungen erreicht werden. Als Beispiel für die Abläufe bei der Erschließung neuer Dienste für die hochschulübergreifende Nutzung wird die Anbindung von Learning Management Systemen auf Basis des DFN-AAI E-Learning-Profils diskutiert. Den umfassenden Vorteilen werden schließlich die aktuellen technischen Grenzen bei der Umsetzung des hochschulübergreifenden Identity Management gegenübergestellt.

  5. Ppb-level formaldehyde detection using a CW room-temperature interband cascade laser and a miniature dense pattern multipass gas cell.

    PubMed

    Dong, Lei; Yu, Yajun; Li, Chunguang; So, Stephen; Tittel, Frank K

    2015-07-27

    A ppb-level formaldehyde (H2CO) sensor was developed using a thermoelectrically cooled (TEC), continuous-wave (CW) room temperature interband cascade laser (ICL) emitting at 3.59 ?m and a miniature dense pattern multipass gas cell with >50 m optical path length. Performance of the sensor was investigated with two measurement schemes: direct absorption (DAS) and wavelength modulation spectroscopy (WMS). With an integration time of less than 1.5 second, a detection limit of ~3 ppbv for H2CO measurement with precision of 1.25 ppbv for DAS and 0.58 ppbv for WMS, respectively, was achieved without zero air based background subtraction. An Allan-Werle variance analysis indicated that the precisions can be further improved to 0.26 ppbv @ 300s for DAS and 69 pptv @ 90 s for WMS, respectively. A side-by-side comparison between two measurement schemes is also discussed in detail. PMID:26367641

  6. Zahlen und Rechenvorgnge auf unterschiedlichen Abstraktionsniveaus

    NASA Astrophysics Data System (ADS)

    Rdler, Klaus

    "Das Verstndnis geht langsam vor sich!" Diesen wichtigen Satz hrte ich bei einem Vortrag von Martin Lowsky. Auf die hier behandelte Fragestellung bertragen heit das: Was eine Zahl ist und wie ich sie im Rechenvorgang einsetzen und interpretieren kann, das erschliet sich erst allmhlich. Die Zahl des Rechenanfngers ist nicht dieselbe wie die des kompetenten Rechners und es ist nicht die Zahl des Lehrers oder der Lehrerin. Die Zahlen sind nur auf der Oberflche der Worte und Zeichen gleich. Im Innern, im Verstndnis, sind sie vllig verschieden! Ich glaube, dass die Missachtung dieser Divergenz dazu fhrt, dass manche Kinder in fr den Lehrer und Lehrerin nicht nachvollziehbaren Routinen stecken bleiben, einfachste Informationen nicht wirklich integrieren. Die auf beiden Seiten wachsende Verunsicherung durch die nicht erkannte und daher nicht kommunizierbare Diskrepanz im inneren Zahlkonzept strt den allmhlichen Aufbau strukturierter Zahlvorstellungen.

  7. Analysis of the acoustic response in water and sand of different fiber optic sensing cables

    NASA Astrophysics Data System (ADS)

    Hofmann, Joachim; Facchini, Massimo; Lowell, Mark

    2015-05-01

    Distributed Acoustic Sensing (DAS) is a highly promising technology to efficiently monitor assets for energy production and transportation, both off- and on-shore, such as boreholes, pipelines and risers. The aim of the hereby-presented measurements is to evaluate the sensitivity of the different optical fiber cables to acoustic signals in sand and water, independently from the DAS read-out unit type and manufacturer. Acoustic sensing cables specifically designed by BRUGG Cables are characterized and compared to standard telecommunication cables. The spectral response of each cable was quantified using an all-fiber Mach-Zehnder interferometer. The response was also measured with calibrated microphones in order to convert the measurements into absolute physical units (Pascal). The measurement campaign is part of an investigation program for a reliable DAS system, which comprises the sensing cable (including installation procedure), the interrogator unit and suitable software.

  8. A Data System for a Rapid Evaluation Class of Subscale Aerial Vehicle

    NASA Technical Reports Server (NTRS)

    Hogge, Edward F.; Quach, Cuong C.; Vazquez, Sixto L.; Hill, Boyd L.

    2011-01-01

    A low cost, rapid evaluation, test aircraft is used to develop and test airframe damage diagnosis algorithms at Langley Research Center as part of NASA's Aviation Safety Program. The remotely operated subscale aircraft is instrumented with sensors to monitor structural response during flight. Data is collected for good and compromised airframe configurations to develop data driven models for diagnosing airframe state. This paper describes the data acquisition system (DAS) of the rapid evaluation test aircraft. A PC/104 form factor DAS was developed to allow use of Matlab, Simulink simulation code in Langley's existing subscale aircraft flight test infrastructure. The small scale of the test aircraft permitted laboratory testing of the actual flight article under controlled conditions. The low cost and modularity of the DAS permitted adaptation to various flight experiment requirements.

  9. Liberalisierung der Energiemrkte

    NASA Astrophysics Data System (ADS)

    Oehler, H.

    Die extremen Preisschwankungen fr Energie Ende der ersten Dekade des 21. Jahrhunderts, gekennzeichnet durch rasant steigende Preise bis zu einem Spitzenwert fr Erdl von knapp unter 150 US- pro Barrel und dem nachfolgenden Absturz aufgrund der Wirtschaftskrise, lassen das Interesse fr Mechanismen an den globalen und lokalen Mrkten fr Energie steigen. In diesem Zusammenhang rcken die Auswirkungen der Liberalisierung der Mrkte fr leitungsgebundene Energien wieder mehr in das Zentrum des Interesses, wobei hufig einerseits Ursachen und Wirkung vermischt, andererseits aber auch vllig verfehlte Erwartungen an die Liberalisierung, die Unternehmen sowie das Kundenverhalten gestellt werden. Zu beobachten ist auerdem, dass die gewnschten Schwerpunkte bei den erhofften Effekten des Wettbewerbs Schwankungen unterliegen, je nachdem welche Interessen gerade meinungsbestimmend sind, z. B. Versorgungssicherheit oder Preise.

  10. IQM-Reifegradmodell fr die Bewertung und Verbesserung des Information Lifecycle Management Prozesses

    NASA Astrophysics Data System (ADS)

    Bakarada, Saa; Gebauer, Marcus; Koronios, Andy; Gao, Jing

    Heutige Organisationen produzieren und speichern mehr Informationen als je zuvor. Der resultierende Informationsberfluss, zusammen mit einem Mangel an Qualittssicherung fr das Information Lifecycle Management, fhrt zu einem unsicheren Status der Informationsqualitt in vielen Organisationen. Weiterhin hat sich herausgestellt, dass das Bewerten, Verbessern und Steuern der Informationsqualitt ein offenkundig schwieriges Unterfangen ist. Dieses Kapitel stellt ein Modell zur Bewertung und Verbesserung der Information Quality Management Capability Maturity (IQM-Reifegrad) vor. Es wird ein Satz von Kriterien vorgestellt, der aus Literaturrecherche und Fallstudien abgeleitet wurde. Die Reifegradindikatoren werden validiert und in einem mehrstufigen Reifegradmodell durch eine Delphi-Studie gruppiert. Das abgeleitete IQM-Reifegradmodell hilft Organisationen ihre bestehenden Praktiken im IQM zu bewerten und potentielle Lcken und Verbesserungsstrategien zu ermitteln.

  11. Anwendung von Methoden der Logistik und Netzplantechnik zur przedenz- und ressourcenbeschrnkten Ablaufplanung von Echtzeitsystemen

    NASA Astrophysics Data System (ADS)

    Gumzej, Roman; Lipi?nik, Martin

    Grundlegende Zusammenhnge zwischen Logistik, Netzplantechnik und Echtzeit sowie den zugehrigen Arten der Ablaufplanung und ihrer Nutzung werden dargestellt. Das Echtzeitprinzip beinhaltet Rechtzeitigkeit von Ablufen, wobei es fr eine frhzeitige Beendigung eines Ablaufs keinen Bonus gibt; im Gegensatz zum verspteten Ablauf, dessen Konsequenzen in der Regel negativ und unabschtzbar sind. Das Just-in-Time-Prinzip gleicht dem der Echtzeit und wird vor allem in der Logistik zur Bezeichnung reibungsloser Ablufe in Beschaffungsketten verwendet. In der Netzplantechnik werden die kritischen Aktivitten binnen eines Projektes bestimmt, die nicht verzgert werden drfen, um das Projekt rechtzeitig zu beenden. Auerdem haben die drei Bereiche noch eine Gemeinsamkeit: um realistische Ablaufszenarien darzustellen, mssen in den Analysen auch begrenzte Ressourcen angemessen bercksichtigt werden.

  12. Kopplung eines auf der Momentenmethode basierenden Computerprogramms mit einem FEM-Algorithmus zur Berechnung von elektromagnetischen Streuproblemen im medizinischen Bereich

    NASA Astrophysics Data System (ADS)

    Schick, M.; Landstorfer, F. M.

    2004-05-01

    Am Beispiel der Verkopplung von medizinischen Gerten ber den menschlichen Krper werden elektromagnetische Strphnomene im Klinikbereich betrachtet. Fr die Berechnung dieser komplexen Szenarien wird zum einen die Momentenmethode (MoM) verwendet, die sich in besonderem Mae fr die Bercksichtigung metallischer Strukturen und offener Streuprobleme eignet, und zum anderen die Methode der Finiten Elemente (FEM), mit der die Eigenschaften des menschlichen Krpers besser bercksichtigt werden knnen. Mit Hilfe des quivalenzprinzips lsst sich das Gesamtproblem in zwei Teile zerlegen, in ein inneres und in ein ueres. Der Auenraum wird dabei mit der MoM behandelt und das Innere, d.h. der Krper mit der FEM. Die Kopplung der beiden Methoden erfolgt an der Krperoberflche ber quivalente Oberflchenstrme. Durch Lsen des resultierenden linearen Gleichungssystems fr das gesamte Problem lassen sich dann die Oberflchenstrme und die ber die Kontinuittsgleichung miteinander verknpften elektromagnetischen Felder bestimmen.

  13. Effect of chitooligosaccharides with different degrees of acetylation on wheat seedlings under salt stress.

    PubMed

    Zou, Ping; Li, Kecheng; Liu, Song; Xing, Ronge; Qin, Yukun; Yu, Huahua; Zhou, Miaomiao; Li, Pengcheng

    2015-08-01

    In this study, chitooligosaccharides (COSs) with varying degrees of acetylation (DAs) were applied to wheat seedlings in order to investigate their effect on the plants' defence response under salt stress. The results showed that treatment with exogenous COSs that had different DAs could promote the growth of plants, decrease the concentration of malondialdehyde (MDA), improve the photosynthetic efficiency and enhance the activities of antioxidant enzymes. The mRNA expression level examination of several salt stress response genes suggested that COS could protect plants from the damage of salt stress by adjusting intracellular ion concentration and enhancing the activities of antioxidant enzymes. Furthermore, COS with DA 50% was the most effective in alleviating salt stress to wheat seedlings, which indicated that the activity of COS was closely related with its DAs. PMID:25933523

  14. Organisation des gesundheitlichen Verbraucherschutzes auf Bundesebene

    NASA Astrophysics Data System (ADS)

    Tschiersky-Schöneburg, Helmut; Büttner, Antje

    Zahlreiche Krisen wie Dioxin belastete Futtermittel, die missbräuchliche Verwendung von Antibiotika in der Schweinemast und nicht zuletzt das Auftreten von BSE in Deutschland erschütterten Ende der neunziger Jahre das Vertrauen der Bürger in die Sicherheit der Lebensmittel. Mit dem Weißbuch zur Lebensmittelsicherheit, das im Januar 2000 herausgegeben wurde, hatte die Europäische Kommission ihre Erfahrungen aus dem BSE-Geschehen in ein neues Konzept für den Verbraucherschutz eingearbeitet. Kernstücke des Konzepts sind die ganzheitliche Betrachtung der Lebensmittelsicherheit von der landwirtschaftlichen Erzeugung bis zum Verzehr und der Anspruch nach Transparenz und Unabhängigkeit der Risikobewertung.

  15. Impact of the higher twist effects on the {gamma}{gamma}*{yields}{pi}{sup 0} transition form factor

    SciTech Connect

    Agaev, S.S.

    2005-12-01

    We reanalyze the {gamma}{gamma}*{yields}{pi}{sup 0} transition form factor F{sub {pi}}{sub {gamma}}(Q{sup 2}) within the QCD light-cone sum rules method with the twist-4 accuracy. In computations, the pion leading twist distribution amplitude (DA) with two nonasymptotic terms and the renormalon method-inspired twist-4 DAs are used. The latters allow us to estimate the impact of effects due to higher conformal spin components in the pion twist-4 DAs on the form factor F{sub {pi}}{sub {gamma}}(Q{sup 2}). Obtained theoretical predictions are employed to deduce constraints on the pion DAs from CELLO and CLEO data.

  16. Kontrollierte therapeutische Systeme (Controlled drug delivery systems)

    NASA Astrophysics Data System (ADS)

    Ha, Suk-Woo; Wintermantel, Erich

    Es gibt eine grosse Anzahl von Arzneistoffen, die nicht mit der hchsten Effizienz eingesetzt werden knnen, weil das geeignete therapeutische System (drug delivery system) fr die optimale Applikation fehlt. Viele Arzneistoffe setzen eine hufige Anwendung voraus und sind oft mit mehr oder weniger starken Nebenwirkungen oder aber mit Beeintrchtigungen von Arbeits- und Lebensrhythmus der Patienten verbunden. Der therapeutische Erfolg einer medikamentsen Behandlung setzt eine korrekte Diagnose, die Wahl der richtigen Wirksubstanz sowie ihr Vorliegen in geeigneter Darreichungsform voraus. Zudem muss ein genauer Verabreichungsplan erstellt werden, dessen Einhaltung seitens der Patienten eine wesentliche Voraussetzung fr die optimale Wirkung des Arzneistoffes ist. Das Mass, mit dem eine Wirksubstanz therapeutisch voll genutzt werden kann, korreliert direkt mit der Darreichungsform, in der sie angewandt wird. Da viele hochwirksame Arzneimittel bereits existieren, hat sich, neben Neuentwicklungen, das Interesse im vergangenen Jahrzehnt der Optimierung von Arzneimittelwirkungen durch neue Darreichungsformen zugewandt.

  17. Changes in biochemical constituents and induction of early sprouting by triadimefon treatment in white yam (Dioscorea rotundata Poir.) tubers during storage

    PubMed Central

    Jaleel, Cheruth Abdul; Gopi, Ragupathi; Manivannan, Paramasivam; Kishorekumar, Ashok; Gomathinayagam, Muthiah; Panneerselvam, Rajaram

    2007-01-01

    The ability of triadimefon (TDM), a triazolic fungicide, to alter the biochemical constituents and thereby minimizing the days required for sprouting in white yam (Dioscorea rotundata Poir.) tubers during storage under (302) C in the dark, was studied. TDM at 20 mg/L was given to tubers by dipping the tubers in treatment solution containing 20 mg/L TDM on 10, 25 and 40 d after storage (DAS). Starch, sugars, protein, amino acid contents as well as protease and ?-amylase activities were estimated on 15, 30 and 45 DAS from two physiological regions viz., apical and basal regions of the tubers. In normal conditions (control) sprouting occurred on 70 to 80 DAS. The starch content decreased, while protein, amino acid, sugar contents and protease and ?-amylase activities were increased due to TDM treatment and led to early sprouting. PMID:17444605

  18. Jahre Entwicklung der Instandhaltung - von der ausfallorientierten Instandhaltung zum gemeinsamen TPM und RCM

    NASA Astrophysics Data System (ADS)

    Iske, Friedhelm

    Zur Einleitung meines Beitrages möchte ich von einem Gespräch mit einem Mitarbeiter berichten, das ich als junger Vorgesetzter einer Instandhaltungsgruppe 1988 führte. Der engagierte Mitarbeiter feierte damals sein vierzigjähriges Dienstjubiläum und war stolz auf das von ihm Geleistete sowie auf den besonderen Einsatz seiner Altersgruppe, die nach dem Zweiten Weltkrieg das Werk wieder aufgebaut hatte. Auf meine Frage, was denn damals die erste Aufgabe in der Firma war, bekam ich kurz und knapp und mit einer Selbstverständlichkeit die selbstbewusste Antwort: "Unser Pferd füttern und mit dem Pferd die innerbetrieblichen Transporte erledigen“. Als junger, technisch orientierter Vorgesetzter war ich über diese Antwort sehr überrascht. Gedanklich weit entfernt war die Vorstellung, dass in der Vergangenheit Transporte mit einem Pferd erledigt wurden.

  19. Software-switching between direct absorption and wavelength modulation spectroscopy for the investigation of ADC resolution requirements

    NASA Astrophysics Data System (ADS)

    Lins, B.; Engelbrecht, R.; Schmauss, B.

    2012-03-01

    We present a tunable diode laser spectrometer that can be software-switched between a wavelength modulation spectroscopy (WMS) operation mode and the direct absorption spectroscopy (DAS) technique on a per-scan basis. The new setup allows a direct comparison between the two techniques under equal hardware and system environment conditions. In this work, we compare the impact of analog-to-digital converter resolution for operation in WMS and DAS mode. Example concentration evaluations show that in the DAS approach, relative absorptions smaller than the least significant bit can be measured with scan averaging and FIR-filtering applied. With full resolution, both techniques show similar performance in our setup, with a slight advantage for the WMS implementation.

  20. Developments in Test Facility and Data Networking for the Altitude Test Stand at the John C. Stennis Space Center, MS - A General Overview

    NASA Technical Reports Server (NTRS)

    Hebert, Phillip W., Sr.

    2008-01-01

    May 2007, NASA's Constellation Program selected John C Stennis Space Center (SSC) near Waveland Mississippi as the site to construct an altitude test facility for the developmental and qualification testing of the Ares1 upper stage (US) engine. Test requirements born out of the Ares1 US propulsion system design necessitate exceptional Data Acquisition System (DAS) design solutions that support facility and propellant systems conditioning, test operations control and test data analysis. This paper reviews the new A3 Altitude Test Facility's DAS design requirements for real-time deterministic digital data, DAS technology enhancements, system trades, technology validation activities, and the current status of this system's new architecture. Also to be discussed will be current network technologies to improve data transfer.

  1. Instandhaltung und Normung

    NASA Astrophysics Data System (ADS)

    Rosenkranz-Wuttig, Angela

    Das DIN Deutsches Institut fr Normung e.V. ist ein eingetragener Verein mit Sitz in Berlin. Das DIN erarbeitet gemeinsam mit den Experten der interessierten Kreise Normen und Standards als Dienstleistung fr Wirtschaft, Staat und Gesellschaft. Die Kenntnis entsprechender Normen, Standards oder Regeln, sowie deren richtiger Einsatz, ist unter den heutigen Marktbedingungen fr jedes Unternehmen ein nicht zu unterschtzender wirtschaftlicher Faktor. Normen schaffen Effizienz bei Produktionsablufen und sorgen durch eine gleichbleibende sowie vergleichbare Produktqualitt fr Vertrauen bei den Endverbrauchern. Darber hinaus stehen Normen unter rechtlichen Aspekten fr mehr Sicherheit - Hersteller erreichen bei Anwendung und Einhaltung von Normen ein hohes Ma an rechtlicher Absicherung. Das DIN vertritt die deutschen Interessen in den europischen und weltweiten Normungsorganisationen, siehe Abb. 1. Zustndig fr die elektrotechnische Normung in Deutschland sowie als deutscher Reprsentant in den bernationalen Gremien ist die DKE Deutsche Kommission Elektrotechnik Elektronik Informationstechnik im DIN und VDE.

  2. Wie verstehen Schlerinnen und Schler den Begriff der Unendlichkeit?

    NASA Astrophysics Data System (ADS)

    Schimmller, Tabea

    Wie Hilbert bereits feststellte, wirkt die Idee der Unendlichkeit, wie keine andere, schon seit Zeiten sehr anregend und fruchtbar auf den Verstand und bewegt das Gemt der Menschen. Der Begriff der Unendlichkeit bedarf aber auch, wie kein anderer, der Aufklrung, denn mit ihm erffnet sich ein weites Feld, welches nicht nur aus vielen verschiedenen Definitionen besteht, sondern auch aus vllig unterschiedlichen Disziplinen. Physiker suchen immer dringender nach einer "Theorie fr Alles" oder einer "Weltformel", Kosmologen beschftigen sich unter anderem mit der Ewigkeit des Universums, Theologen interessiert eher die Unendlichkeit Gottes, Philosophen diskutieren unter anderem Grenzfragen zwischen Naturwissenschaft und Philosophie und die Mathematiker versuchen den Paradoxien des Unendlichen einen Sinn zu geben. Und so wird ersichtlich, dass nichts abstrakter ist als das Unendliche: Obwohl die Unendlichkeit fr die unterschiedlichsten Wissenschaften von groer Bedeutung ist, "[ist] in der Wirklichkeit das Unendliche nirgends zu finden, [egal] was fr Erfahrungen und Beobachtungen und welcherlei Wissenschaft wir auch heranziehen".

  3. Chromium-induced alterations in photosynthesis and associated attributes in Indian mustard.

    PubMed

    Diwan, Hema; Ahmad, Altaf; Iqbal, Muhammad

    2012-03-01

    Contamination of soil and water by chromium (Cr) is increasing enormously due to anthropogenic activities. The potential of plants to accumulate or stabilize Cr compounds forthe purpose of remediation of Cr contamination has been recognized in recent years. We conducted pot experiments to study photosynthesis and associated attributes in cv Pusa Jai Kisan of Indian mustard under natural as well as Cr-loaded environmental conditions. High doses of Cr caused toxic effects in plants, as evident by a reduction in photosynthetic rate (24.3 to 8.7 micromol CO2 m(-2)s(-1) at 80 DAS), nitrate reductase activity (3.76 to 1.30 micromol nitrite g(-1) f. wt. h(-1) at 80 DAS) and the contents of chlorophyll (1.49 to 0.86 mg g(-1) f. wt. at 80 DAS) and soluble protein (2.96 to 1.93 mg g(-1) f. wt. at 80 DAS). Since plants lack a specific Cr-transport system, mineral nutrient contents also changed due to Cr toxicity. Cr accumulation in different plant parts was affected by both duration and dose of Cr treatments, with a maximal localization of Cr in roots (up to 0.77 mg g(-1) d. wt) at initial stages (40 DAS) and in stem (up to 4.19 mg g(-1) d. wt) at the later stage (80 DAS) of plant growth. Thus, Indian mustard was able to withstand Cr stress and protect itself from Cr toxicity by altering various metabolic processes. Owing to its ability to accumulate large amounts of Cr, it may be useful in the process of land reclamation. PMID:23033687

  4. Variation in Type A Trichothecene Production and Trichothecene Biosynthetic Genes in Fusarium goolgardi from Natural Ecosystems of Australia

    PubMed Central

    Rocha, Liliana O.; Laurence, Matthew H.; Proctor, Robert H.; McCormick, Susan P.; Summerell, Brett A.; Liew, Edward C. Y.

    2015-01-01

    Fusarium goolgardi, isolated from the grass tree Xanthorrhoea glauca in natural ecosystems of Australia, is closely related to fusaria that produce a subgroup of trichothecene (type A) mycotoxins that lack a carbonyl group at carbon atom 8 (C-8). Mass spectrometric analysis revealed that F. goolgardi isolates produce type A trichothecenes, but exhibited one of two chemotypes. Some isolates (50%) produced multiple type A trichothecenes, including 4,15-diacetoxyscirpenol (DAS), neosolaniol (NEO), 8-acetylneosolaniol (Ac-NEO) and T-2 toxin (DAS-NEO-T2 chemotype). Other isolates (50%) produced only DAS (DAS chemotype). In the phylogenies inferred from DNA sequences of genes encoding the RNA polymerase II largest (RPB1) and second largest (RPB2) subunits as well as the trichothecene biosynthetic genes (TRI), F. goolgardi isolates were resolved as a monophyletic clade, distinct from other type A trichothecene-producing species. However, the relationships of F. goolgardi to the other species varied depending on whether phylogenies were inferred from RPB1 and RPB2, the 12-gene TRI cluster, the two-gene TRI1-TRI16 locus, or the single-gene TRI101 locus. Phylogenies based on different TRI loci resolved isolates with different chemotypes into distinct clades, even though only the TRI1-TRI16 locus is responsible for structural variation at C-8. Sequence analysis indicated that TRI1 and TRI16 are functional in F. goolgardi isolates with the DAS-NEO-T2 chemotype, but non-functional in isolates with DAS chemotype due to the presence of premature stop codons caused by a point mutation. PMID:26556373

  5. Factors associated with the intensification of treatment in rheumatoid arthritis in clinical practice.

    PubMed

    Naranjo, Antonio; Cceres, Laura; Hernndez-Berian, Jos ngel; Francisco, Flix; Ojeda, Soledad; Talaverano, Sigrid; Nvoa-Medina, Javier; Martn, Jos Adn; Delgado, Esmeralda; Trujillo, Elisa; lvarez, Ftima; Magdalena, Laura; Rodrguez-Lozano, Carlos

    2015-11-01

    The aim of the present study was to analyse the patterns of treatment adjustment in rheumatoid arthritis (RA) patients with active disease in routine clinical care. This was a cross-sectional study of consecutive patients with RA conducted in five hospitals. Activity scales (DAS28-ESR) and function (HAQ) were measured, as well as whether ultrasound was performed as part of the assessment. Treatment decision (no changes/reduction/intensification) and time to the next scheduled visit were the outcomes variables. Associated factors were analysed by multilevel regression models. A total of 343 patients were included (77% women, mean age 57years, mean RA duration 10years), of whom 44% were in remission by DAS28. Treatment was continued in 202 (59%) patients, reduced in 57 (16%), and intensified in 83 (24%). In the 117 patients with active RA (DAS28?3.2), treatment was intensified in 61 (52%). Factors associated with treatment intensification were physician and patient VAS, and DAS28, but not the centre. In the multilevel regression analysis with intensification of treatment as dependent variable, the following factors were significantly associated: DAS28 [OR 3.67 (95% CI 2.43-5.52)], patient VAS [OR 1.04 (95% CI 1.01-1.08)], and have performed an ultrasound [OR 3.36 (95% CI 1.47-7.68)]. Factors associated with time to the next scheduled visit (an average of 4.3months) were patient and physician VAS, DAS28, and centre. In clinical practice, half of the patients with active RA maintain or reduce the treatment. The decision to intensify treatment in active RA as recommended by a treat-to-target strategy is complex in practice. PMID:26238094

  6. The Taiwanese Derriford Appearance Scale: The translation and validation of a scale to measure individual responses to living with problems of appearance.

    PubMed

    Moss, Timothy Peter; Lawson, Victoria; Liu, Chiu Ying

    2015-09-01

    The extent of concern about physical appearance is increasingly the subject of scientific study, interventions by health professionals, and media attention. To enable carefully evaluated studies exploring the psychosocial antecedents of appearance distress, and to determine the success of interventions, the Derriford Appearance Scale 24 (DAS24) was developed. This psychometrically sound measure is well used and cited in the appearance psychology field. Outside of a Western context, the extent and impact of appearance distress is less well known. This paper describes the adaptation of the DAS24 for use in Taiwan. A formal translation protocol was followed to adapt the DAS24 into Taiwanese/Cantonese. Two hundred and eight participants from a general population and a visibly different population were recruited in Taipei, Taiwan. These participants completed a test pack administered comprising the translated DAS24, and established measures of anxiety and depression. The scale was analyzed on the basis of classical test theory. A translated DAS Scale comprising 19 items and including three clear factors was the best solution. The scale had good internal consistency, clear convergent validity, and good test-retest reliability. The three factors that emerged were appearance-related social avoidance, social distress, and negative affect. Consistent with expectations, (a) women scored higher than men (greater appearance distress), (b) the cause of appearance difference (burns, cleft lip/palate, etc.) was unrelated to appearance distress, and (c) those with visible differences were more concerned about their appearance than those without. The Taiwanese DAS19 is a user-friendly and psychometrically sound scale that fulfils an important clinical and scientific need. The items that were omitted from the translated version were considered in relation to cultural differences in the experience and expression of shame between Western countries and Taiwan/China, which demands a careful future analysis. PMID:26354154

  7. Comparative evaluation of the potency and antigenicity of two distinct BoNT/A-derived formulations.

    PubMed

    Brown, M; Nicholson, G; Ardila, M C; Satorius, A; Broide, R S; Clarke, K; Hunt, T; Francis, J

    2013-02-01

    IncobotulinumtoxinA (Xeomin) and onabotulinumtoxinA (BOTOX) are unique botulinum neurotoxin type A (BoNT/A)-derived drugs. IncobotulinumtoxinA utilizes the naked 150 kDa holotoxin portion of BoNT/A, whereas onabotulinumtoxinA uses the complete native 900 kDa complex as drug substance. On the basis of purportedly similar pharmacological characteristics, these formulations were evaluated for potency by LD?? and mouse Digit Abduction Score (DAS) bioassays. DAS was also used to assess antigenicity. Full-range DAS dose-response profiles were achieved with four lots of each product, with similar observations between lots for a given product. Between products, however, the mean DAS potency of incobotulinumtoxinA (ED?? range 7.0-10.2 U/kg) was significantly lower than that of onabotulinumtoxinA (ED?? range 4.4-6.4 U/kg), consistent with lower measured potencies in the LD?? assay for incobotulinumtoxinA (potency range 62-82 U). In assessments of DAS duration of effect at similar unit doses, the observed lower potency of incobotulinumtoxinA translated into decreased peak efficacy and dose effect over time (i.e. shorter duration). In contrast, at equi-efficacious doses yielding near-maximal DAS responses, both toxin formulations were uniformly inhibited in a statistically significant manner when preincubated with rabbit-derived, onabotulinumtoxinA-neutralizing antibodies, supporting the position that inhibition of 150 kDa holotoxin serves as the common basis for neutralization and, therefore, incobotulinumtoxinA would not be expected to be effective in onabotulinumtoxinA-immunoresistant subjects (and vice versa). Further, with lower lot-to-lot relative potency, incobotulinumtoxinA is not dose-equivalent or interchangeable with onabotulinumtoxinA, suggesting that various aspects of drug product formulation may influence observed pharmacology. PMID:22842675

  8. Predictive factors for achieving low disease activity at 52 weeks after switching from tumor necrosis factor inhibitors to abatacept: results from a multicenter observational cohort study of Japanese patients.

    PubMed

    Kojima, Toshihisa; Takahashi, Nobunori; Kaneko, Atsushi; Kida, Daihei; Hirano, Yuji; Fujibayashi, Takayoshi; Yabe, Yuichiro; Takagi, Hideki; Oguchi, Takeshi; Miyake, Hiroyuki; Kato, Takefumi; Watanabe, Tsuyoshi; Hayashi, Masatoshi; Shioura, Tomone; Kanayama, Yasuhide; Funahashi, Koji; Asai, Shuji; Yoshioka, Yutaka; Terabe, Kenya; Takemoto, Toki; Asai, Nobuyuki; Ishiguro, Naoki

    2016-01-01

    This study aimed to identify predictive factors for achieving low disease activity (LDA) in rheumatoid arthritis (RA) patients switching from tumor necrosis factor inhibitors (TNFis) to abatacept (ABT). Patients who were registered in the multicenter observational Tsurumai Biologics Communication Registry (TBCR) were enrolled in this study. Predictive factors for LDA achievement at each time point were determined by univariate and multivariate logistic regression analyses. The cutoffs of 28-point count Disease Activity Score (DAS28)-C-reactive protein (CRP) and ΔDAS28-CRP from baseline up to 24 weeks for LDA achievement at 52 weeks were explored using receiver operating characteristic (ROC) curves. Of 2771 RA patients registered until 2013, 76 with moderate or high disease activity were selected. Twenty-six percent of the patients achieved LDA. Multivariate analysis confirmed that DAS28-CRP at 12 weeks and ΔDAS28-CRP from baseline to 12 weeks were independent factors for LDA achievement at 52 weeks [odds ratio (OR) 0.26, 95 % confident interval (CI) (0.12-0.56), OR 0.25, 95 % CI (0.11-0.57), respectively]. The best cutoff values of DAS28-CRP at 12 weeks and ΔDAS28-CRP from baseline to 12 weeks for LDA at 52 weeks were 3.9 (sensitivity 0.85, specificity 0.78) and -0.97 (sensitivity 0.70, specificity 0.70), respectively. Seventy-one percent of patients who achieved both of these cutoff values at 12 weeks achieved LDA at 52 weeks. Our findings suggest that the clinical course up to 12 weeks is important for predicting long-term outcomes when switching from TNFis to ABT. PMID:26631102

  9. Retting of jute grown in arsenic contaminated area and consequent arsenic pollution in surface water bodies.

    PubMed

    Majumder, Aparajita; Bairagya, M D; Basu, B; Gupta, P C; Sarkar, S

    2013-01-01

    Arsenic (As) toxicity of ground water in Bengal delta is a major environmental catastrophe. Cultivation of jute, a non edible crop after summer rice usually reduces arsenic load of the soil. However, during retting of jute As is present in the crop and thus increase its amount in surface water bodies. To test this hypothesis, a study was carried out in ten farmers' field located in As affected areas of West Bengal, India. As content of soil and variou the jute plant were recorded on 35 and 70 days after sowing (DAS) as well as on harvest date (110 DAS). During the study period, due to the influence of rainfall, As content of surface (0-150 mm) soil fluctuates in a narrow range. As content of jute root was in the range of 1.13 to 9.36 mg kg(-1). As content of both root and leaf attained highest concentration on 35 DAS and continuously decreased with the increase in crop age. However, in case of shoot, the As content initially decreased by 16 to 50% during 35 to 70 DAS and on 110 DAS the value slightly increased over 70 DAS. Retting of jute in pond water increased the water As content by 0.2 to 2.0 mg L(-1). The increment was 1.1 to 4 times higher over the WHO safe limit (0.05 mg L(-1)) for India and Bangladesh. Microbiological assessment in this study reveals the total bacterial population of pre and post retting pond water. Bacterial strains capable in transforming more toxic As-III to less toxic AS-V were screened and six of them were selected based on their As tolerance capacity. Importantly, identified bacterial strain Bacterium C-TJ19 (HQ834294) has As transforming ability as well as pectinolytic activity, which improves fibre quality of jute. PMID:23178784

  10. Effect of diallyl sulfide on rat liver microsomal nitrosamine metabolism and other monooxygenase activities.

    PubMed

    Brady, J F; Li, D C; Ishizaki, H; Yang, C S

    1988-11-01

    It has been reported that p.o. administration of diallyl sulfide (DAS), a naturally occurring component of garlic (Allium sativum), inhibits 1,2-dimethylhydrazine-induced colon and liver cancer in rodents. A possible mechanism for this protective effect is inhibition of hepatic activation of the procarcinogen. The effect of DAS on P450IIE1, an isozyme of cytochrome P-450 which is active in the oxidative metabolism of dimethylhydrazine, was conveniently assayed in the present study by determination of N-dimethylnitrosamine demethylase (NDMAd) activity at 1 mM N-dimethylnitrosamine in Sprague-Dawley rat liver microsomal incubations. DAS was found to be a competitive inhibitor of NDMAd, in contrast to the irreversible inactivation of NDMAd produced by carbon tetrachloride incubated under similar conditions. The inhibition by DAS of the demethylation of several substrates was selective. The thioether was most potent against N-dimethylnitrosamine, less effective against N-nitrosomethylbenzylamine, and essentially ineffective against benzphetamine and ethylmorphine. Microsomes prepared at 3 h after DAS administration (200 mg/kg in corn oil intragastrically) showed moderate inhibition (less than 30% inhibition compared to control microsomes) of several demethylase activities; however, microsomes prepared 18 h posttreatment showed a marked decrease (about 80% inhibition compared to controls) in NDMAd activity, minor effects on other demethylase activities, and a 6-fold increase in pentoxyresorufin dealkylation. These trends at 18 h agreed with immunoblot analyses which showed suppression in the level of P450IIE1 and an elevation in P450IIB1. The selective inhibition of P450IIE1 activity and suppression of its level in microsomes may contribute to the reported chemoprotective effects of DAS. PMID:3167846

  11. Dasatinib promotes the expansion of a therapeutically superior T-cell repertoire in response to dendritic cell vaccination against melanoma

    PubMed Central

    Lowe, Devin B; Bose, Anamika; Taylor, Jennifer L; Tawbi, Hussein; Lin, Yan; Kirkwood, John M; Storkus, Walter J

    2014-01-01

    Dasatinib (DAS) is a potent inhibitor of the BCR-ABL, SRC, c-KIT, PDGFR, and ephrin tyrosine kinases that has demonstrated only modest clinical efficacy in melanoma patients. Given reports suggesting that DAS enhances T cell infiltration into the tumor microenvironment, we analyzed whether therapy employing the combination of DAS plus dendritic cell (DC) vaccination would promote superior immunotherapeutic benefit against melanoma. Using a M05 (B16.OVA) melanoma mouse model, we observed that a 7-day course of orally-administered DAS (0.1 mg/day) combined with a DC-based vaccine (VAC) against the OVA257264 peptide epitope more potently inhibited tumor growth and extended overall survival as compared with treatment with either single modality. The superior efficacy of the combinatorial treatment regimen included a reduction in hypoxic-signaling associated with reduced levels of immunosuppressive CD11b+Gr1+ myeloid-derived suppressor cells (MDSC) and CD4+Foxp3+ regulatory T (Treg) populations in the melanoma microenvironment. Furthermore, DAS + VAC combined therapy upregulated expression of Type-1 T cell recruiting CXCR3 ligand chemokines in the tumor stroma correlating with activation and recruitment of Type-1, vaccine-induced CXCR3+CD8+ tumor-infiltrating lymphocytes (TILs) and CD11c+ DC into the tumor microenvironment. The culmination of this bimodal approach was a profound spreading in the repertoire of tumor-associated antigens recognized by CD8+ TILs, in support of the therapeutic superiority of combined DAS + VAC immunotherapy in the melanoma setting. PMID:24734217

  12. Leucocyte complement receptor 1 (CR1/CD35) transcript and its correlation with the clinical disease activity in rheumatoid arthritis patients

    PubMed Central

    Anand, D; Kumar, U; Kanjilal, M; Kaur, S; Das, N

    2014-01-01

    In view of the exaggerated complement activation in rheumatoid arthritis (RA) and significance of complement receptor 1 (CR1/CD35) as a complement regulatory protein (CRP), we aimed to determine the leucocyte-complement receptor 1 (L-CR1) transcript levels and the relationship of this protein with the clinical disease activity of RA patients. Sixty-six controls and 45 RA patients were enrolled. L-CR1 transcript levels were correlated with the levels of circulating immune complexes (CIC), C3, C4 and C3d in controls and patients and with disease activity score 28 (DAS28) in patients only. CIC levels were determined by polyethylene glycol (PEG) precipitation, C3 and C4 levels by nephlometry and C3d levels by enzyme-linked immunosorbent assay (ELISA). Eleven patients were recruited for follow-up of L-CR1 and DAS28 levels at weeks 0, 12 and 24. Appropriate statistical methods were used for the data analysis. L-CR1 (P?DAS28, CIC and C3d. DAS28 correlated positively with levels of CIC, C3 and C3d. Levels of CIC correlated positively with C3 and C3d. Levels of C3 correlated positively with C3d in patients and with C4 in both controls and patients. Levels of L-CR1 increased with decline in DAS28 scores in follow-up patients. Observations were statistically significant. Lower levels of L-CR1 transcript in patients compared to controls, their correlations with the levels of CIC, C3d and DAS28 at different time-points in RA patients suggest CR1 as a potential disease marker for RA. PMID:24433281

  13. Variation in Type A Trichothecene Production and Trichothecene Biosynthetic Genes in Fusarium goolgardi from Natural Ecosystems of Australia.

    PubMed

    Rocha, Liliana O; Laurence, Matthew H; Proctor, Robert H; McCormick, Susan P; Summerell, Brett A; Liew, Edward C Y

    2015-01-01

    Fusarium goolgardi, isolated from the grass tree Xanthorrhoea glauca in natural ecosystems of Australia, is closely related to fusaria that produce a subgroup of trichothecene (type A) mycotoxins that lack a carbonyl group at carbon atom 8 (C-8). Mass spectrometric analysis revealed that F. goolgardi isolates produce type A trichothecenes, but exhibited one of two chemotypes. Some isolates (50%) produced multiple type A trichothecenes, including 4,15-diacetoxyscirpenol (DAS), neosolaniol (NEO), 8-acetylneosolaniol (Ac-NEO) and T-2 toxin (DAS-NEO-T2 chemotype). Other isolates (50%) produced only DAS (DAS chemotype). In the phylogenies inferred from DNA sequences of genes encoding the RNA polymerase II largest (RPB1) and second largest (RPB2) subunits as well as the trichothecene biosynthetic genes (TRI), F. goolgardi isolates were resolved as a monophyletic clade, distinct from other type A trichothecene-producing species. However, the relationships of F. goolgardi to the other species varied depending on whether phylogenies were inferred from RPB1 and RPB2, the 12-gene TRI cluster, the two-gene TRI1-TRI16 locus, or the single-gene TRI101 locus. Phylogenies based on different TRI loci resolved isolates with different chemotypes into distinct clades, even though only the TRI1-TRI16 locus is responsible for structural variation at C-8. Sequence analysis indicated that TRI1 and TRI16 are functional in F. goolgardi isolates with the DAS-NEO-T2 chemotype, but non-functional in isolates with DAS chemotype due to the presence of premature stop codons caused by a point mutation. PMID:26556373

  14. Dissimilatory Arsenate Reduction and In Situ Microbial Activities and Diversity in Arsenic-rich Groundwater of Chianan Plain, Southwestern Taiwan.

    PubMed

    Das, Suvendu; Liu, Chia-Chuan; Jean, Jiin-Shuh; Liu, Tsunglin

    2016-02-01

    Although dissimilatory arsenic reduction (DAsR) has been recognized as an important process for groundwater arsenic (As) enrichment, its characterization and association with in situ microbial activities and diversity in As-rich groundwater is barely studied. In this work, we collected As-rich groundwater at depths of 23, 300, and 313m, respectively, from Yenshui-3, Budai-Shinwen, and Budai-4 of Chianan plain, southwestern Taiwan, and conducted incubation experiments using different electron donors, acceptors, and sulfate-reducing bacterial inhibitor (tungstate) to characterize DAsR. Moreover, bacterial diversity was evaluated using 454-pyrosequencing targeting bacterial 16S rRNAs. MPN technique was used to enumerate microorganisms with different in situ metabolic functions. The results revealed that DAsR in groundwater of Chianan plain was a biotic phenomenon (as DAsR was totally inhibited by filter sterilization), enhanced by the type of electron donor (in this case, lactate enhanced DAsR but acetate and succinate did not), and limited by the availability of arsenate. In addition to oxidative recycling of As(III), dissolution of As(V)-saturated manganese andiron minerals by indigenous dissimilatory Mn(IV)- andFe(III)-reducing bacteria, and abiotic oxidation of As(III) withMn(IV) regenerated As(V) in the groundwater. Sulfate-respiring bacteria contributed 7.4 and 28.2% to the observed DAsR in groundwater of Yinshui-3 and Budai-Shinwen, respectively, whereas their contribution was negligible in groundwater of Budai-4. A noticeable variation in dominant genera Acinetobacter and Bacillus was observed within the groundwater. Firmicutes dominated in highly As-rich groundwater of Yenshui-3, whereas Proteobacteria dominated in comparatively less As-rich groundwater of Budai-Shinwen and Budai 4. PMID:26219267

  15. Elementarteilchen und inflationrer Kosmos. Zur gegenwrtigen Theorienbildung.

    NASA Astrophysics Data System (ADS)

    Linde, A.

    This book is a German translation of the Russian original "Fizika ehlementarnykh chastits i inflyatsionnaya kosmologiya" published in 1990 (see 51.003.012). Contents: 1. Elementarteilchenphysik und inflationre Kosmologie - ein berblick. 2. Skalarfeld, effektives Potential und spontane Symmetriebrechung. 3. Die Wiederherstellung der Symmetrie bei hohen Temperaturen. 4. Phasenbergnge bei wachsender Dichte in kalter Materie. 5. Die Theorie der Tunnelbergnge und der Zerfall einer metastabilen Phase in einem Phasenbergang erster Ordnung. 6. Phasenbergnge im heien Universum. 7. Grundprinzipien der inflationren Kosmologie. 8. Das neue Szenarium des inflationren Universums. 9. Das Szenarium der chaotischen Inflation. 10. Inflation und Quantenkosmologie.

  16. The Jump Problem in Fourth-Order Gravity

    NASA Astrophysics Data System (ADS)

    Giering, K.

    Using a shock wave ansatz, first, the fourth-order jump problem in gravitational theories containing fourth derivatives of the metric is investigated and, second, the obtained results are generalized for arbitrary n-order jumps. For fourth-order jumps, in particular, the dynamic modes of the field are analysed.Translated AbstractDas Sprungproblem in Gravitationstheorien vierter OrdnungUnter Verwendung eines Stowellenansatzes wird zunchst in Gravitationstheorien mit vierten Ableitungen der Metrik das Sprungproblem vierter Ordnung untersucht und danach werden die dabei erzielten Ergebnisse fr Sprnge beliebiger Ordnung verallgemeinert. Im Falle metrischer Sprnge vierter Ordnung werden insbesondere die dynamischen Moden des Feldes analysiert.

  17. Konstruieren von Pkw-Karosserien: Grundlagen, Elemente und Baugruppen, Vorschriftenübersicht, Beispiele mit CATIA V4 und V5

    NASA Astrophysics Data System (ADS)

    Grabner, Jörg; Nothhaft, Richard

    Die Faszination, die vom Auto ausgeht, ist und bleibt ungebrochen. Entsprechend interessant ist es, sich vor dem Hintergrund konventioneller Konstruktionstechniken über die virtuelle Produktentwicklung von Pkw-Karosserien an modernen CAD-Arbeitsplätzen informieren zu können. Die Autoren führen in die Grundlagen ein und zeigen anhand von Beispielen und zahlreichen Abbildungen, wie mit dem System CATIA der Rohbau sowie die Ausstattung innen und au=C3=9Fen konstruiert werden. Darüber hinaus wird das so genannte "Package" an Beispielen beschrieben, also das Management und die Harmonisierung der Anforderungen an die Bauräume (z.

  18. A prototype Distributed Audit System

    SciTech Connect

    Banning, D.L.

    1993-08-01

    Security auditing systems are used to detect and assess unauthorized or abusive system usage. Historically, security audits were confined to a single computer system. Recent work examines ways of extending auditing to include heterogeneous groups of computers (distributed system). This paper describes the design and prototype development of a Distributed Audit System (DAS) which was developed with funding received from Lawrence Livermore Laboratory and through the Master`s thesis effort performed by the author at California State University, Long Beach. The DAS is intended to provide collection, transfer, and control of audit data on distributed, heterogeneous hosts.

  19. Victor F. Weisskopf (1908 - 2002): Physikgeschichte

    NASA Astrophysics Data System (ADS)

    Jacobi, Manfred

    2002-11-01

    Universal gebildete und interessierte Menschen sind selten geworden in unserer Zeit. Victor F. Weisskopf war einer von ihnen. Sein geistiger Horizont umfasste nicht nur sein eigentliches Fachgebiet, die Physik, wo er sich durch fundamentale Arbeiten in den Bereichen der Quantenfeldtheorie, der Kern- und Elementarteilchenphysik hervortat. Daneben bildeten Kunst und Musik sowie ein auergewhnliches Engagement in sozialen und politischen Angelegenheiten die Eckpunkte seines Lebens. Der Einsatz fr die Verstndigung zwischen den Machtblcken whrend des Kalten Krieges war fr ihn ebenso selbstverstndlich wie das Bedrfnis, die neuen Ideen der Physik einem breiten Publikum nahe zu bringen. Die Wissenschaft erschien ihm als das geeignete Mittel, um zum Wohle der Menschheit zu wirken.

  20. Demokrit und die Quantenmechanik

    NASA Astrophysics Data System (ADS)

    Wahsner, Renate

    Es wird gezeigt, daß der antike Atomismus ein auch für die moderne Physik fundamentales Denkprinzip begründete, ein Prinzip, das es in seiner Newtonschen Modifizierung ermöglicht, die Bewegung und das Kontinuum physikalisch zu fassen.Translated AbstractDemocrit and Quantum MechanicsIt is shown that the antique atomisms founded a thought principle which has also a fundamental meaning for modern physics, a principle which in its Newtonian version makes it possible to grasp motion and continuum physically.