Note: This page contains sample records for the topic vitae lewis nelson from Science.gov.
While these samples are representative of the content of Science.gov,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of Science.gov
to obtain the most current and comprehensive results.
Last update: November 12, 2013.
1

CURRICULUM VITAE - Philip Edwin Nelson  

Center for Biologics Evaluation and Research (CBER)

... USDA. National ... $208,000, 2 years. USDA 1998. Continuous Chlorine Gas Treatment Tunnel System, $599,790, 3 years USDA. Improving ... More results from www.fda.gov/advisorycommittees/committeesmeetingmaterials/foodadvisorycommittee

2

Causes, Diet: Prevention, Nelson  

NSDL National Science Digital Library

Professor Nelson explains that chlorophyll is a remarkable energy scavenger and that there is some hint that if you consume chlorophyll you can intercept chemical species, that damage proteins, DNA, and RNA.

2009-12-26

3

Curriculum Vitae: James Liebmann  

Center for Biologics Evaluation and Research (CBER)

Text VersionPage 1. CURRICULUM VITAE James E. Liebmann, MD August, 2011 ... Date (b) (6) (b) (6) Page 2. Curriculum vitae James E. Liebmann, MD Page 2 ... More results from www.fda.gov/downloads/advisorycommittees/committeesmeetingmaterials

4

Curriculum Vitae: Jack Cook  

Center for Biologics Evaluation and Research (CBER)

Text VersionPage 1. CURRICULUM VITAE Last Name: Cook First Name: Jack Middle Initial: A Today's Date: (dd Mmm yyyy): 23 AUG 2012 ... More results from www.fda.gov/downloads/advisorycommittees/committeesmeetingmaterials

5

Curriculum Vitae: Clifford Rosen  

Center for Biologics Evaluation and Research (CBER)

Text Version... S, Kapoor A, Singgih A, Zhang Z, Taylor T, Yu ... Lichtler AC, Gronowicz GA, Adams DJ, Clark SH, Rosen ... MR, Meunier PJ, Nelson DA, Peel NF, Raisz ... More results from www.fda.gov/downloads/advisorycommittees/committeesmeetingmaterials

6

Nelson Mandela: Partisan and Peacemaker  

Microsoft Academic Search

To analyze Nelson Mandela's personal attributes relevant to peacemaking and negotiation, the study considers personality traits derived from biographical data rather than quantitative content analysis. Since Mandela's personality eludes ready characterization in terms of high or low levels of a given trait and also comprises traits apparently in tension, the analysis offered here highlights ostensibly opposing characteristics, and the evolution

Daniel Lieberfeld

2003-01-01

7

Lewy bodies  

PubMed Central

Lewy bodies (LB) in the substantia nigra are a cardinal pathological feature of Parkinson's disease, but they occur in a number of neurodegenerative diseases and can be widespread in the nervous system. The characteristics, locations, and composition of LB are reviewed, with particular attention to ?-synuclein (?-SYN), which appears to be the major component of LB. The propensity for ?-SYN, a presynaptic protein widely expressed in the brain, to aggregate is because of an amyloidogenic central region. The factors that favor the aggregation of ?-SYN and mechanisms of toxicity are examined, and a mechanism through which aggregates of ?-SYN could induce mitochondrial dysfunction and/or release of proapoptotic molecules is proposed.

Shults, Clifford W.

2006-01-01

8

Mercury levels of Nelson’s and saltmarsh sparrows at wintering grounds in Virginia, USA  

Microsoft Academic Search

Nelson’s and saltmarsh sparrows (Ammodramus nelsoni and A. caudacutus) have recently been recognized as separate species, and because of their limited distributions and the susceptibility of\\u000a their wetland habitats to climate change, these two new species are of conservation concern. Both species are known to bioaccumulate\\u000a mercury at breeding sites in New England, USA where their ranges overlap, with the

Daniel A. CristolFletcher; Fletcher M. Smith; Claire W. Varian-Ramos; Bryan D. Watts

9

Mercury in breeding and wintering Nelson’s Sparrows ( Ammodramus nelsoni )  

Microsoft Academic Search

The objective of this study was to increase our understanding of Hg exposure in birds with obligate ties to coastal salt marsh\\u000a and inland wetland systems. Many species filling such niches are of conservation concern because of reduced size and quality\\u000a of vital habitats. We used Nelson’s Sparrow (Ammodramus nelsoni) as an indicator of regional mercury (Hg) availability in its

V. L. WinderS; S. D. Emslie

2011-01-01

10

Orbital angular momentum in Nelson's stochastic mechanics  

NASA Astrophysics Data System (ADS)

We provide numerical examples of integer-valued functionals of Nelson's stochastic processes. More precisely, we consider stochastic motion, according to Nelson's form of Newton's second law of dynamics, in a magnetic field having an axis z of cylindrical symmetry and a gradient in the direction of this axis. We show that there are two sets of functionals of the stochastic process having the same law as the component of quantum mechanical angular momentum along z. The functionals of the first set involve the z coordinate of the process and correctly model the behaviour of the `needle of the measuring apparatus'. The functionals of the second set involve the coordinates in a plane orthogonal to z and strongly suggest the possibility of a stochastic model of the collapse of the `system' toward the state indicated by the `needle'.

Apolloni, Bruno; de Falco, Diego

2000-04-01

11

CURRICULUM VITAE DAVID F. RANSOHOFF, MD Birthdate ...  

Center for Biologics Evaluation and Research (CBER)

Text VersionPage 1. CURRICULUM VITAE DAVID F. RANSOHOFF, MD ... 94. Imperiale TF, Glowinski EA, Juliar BE, Azzouz F, Ransohoff DF. ... More results from www.fda.gov/downloads/advisorycommittees/committeesmeetingmaterials

12

Lewis Acid Organocatalysts  

NASA Astrophysics Data System (ADS)

The term Lewis acid catalysts generally refers to metal salts like aluminium chloride, titanium chloride and zinc chloride. Their application in asymmetric catalysis can be achieved by the addition of enantiopure ligands to these salts. However, not only metal centers can function as Lewis acids. Compounds containing carbenium, silyl or phosphonium cations display Lewis acid catalytic activity. In addition, hypervalent compounds based on phosphorus and silicon, inherit Lewis acidity. Furthermore, ionic liquids, organic salts with a melting point below 100 °C, have revealed the ability to catalyze a range of reactions either in substoichiometric amount or, if used as the reaction medium, in stoichiometric or even larger quantities. The ionic liquids can often be efficiently recovered. The catalytic activity of the ionic liquid is explained by the Lewis acidic nature of their cations. This review covers the survey of known classes of metal-free Lewis acids and their application in catalysis.

Sereda, Oksana; Tabassum, Sobia; Wilhelm, René

13

9. Historic American Buildings Survey, Nelson E. Baldwin, Photographer Dec. ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

9. Historic American Buildings Survey, Nelson E. Baldwin, Photographer Dec. 1936, (F) EXTERIOR, DETAIL OF ENTRANCE DOORWAY. - Dutch Reformed Church, State Route 10, Stone Arabia, Montgomery County, NY

14

A Day in the Life at DaVita Academy  

ERIC Educational Resources Information Center

|When a company name means "giving life," the bar for learning and development programs is held high. In this article, the author describes what it takes to graduate from DaVita Academy, the soft skills training program dialysis services company DaVita offers all its employees. DaVita's chief executive officer, Kent Thiry, states that the Academy…

Weinstein, Margery

2010-01-01

15

Lewy Body Dementia Association  

MedlinePLUS

... Understanding Behavioral Changes in Dementia LBD Treatment Options Caregiver Burden in Lewy Body Dementias 10 Things You Should Know About LBD LBD Diagnostic Symptoms Checklist Comprehensive LBD Symptoms Checklist Read the Lewy Body Digest LBD Caregiver Link – 800.539.9767 What's New Tweets by @ ...

16

Are There Lewis Conventions?  

Microsoft Academic Search

David Lewis famously proposed to model conventions as solutions to coordination games, where equilibrium selection is driven by precedence, or the history of play. A characteristic feature of Lewis Conventions is that they are intrinsically non- normative. Some philosophers have argued that for this reason they miss a crucial aspect of our folk notion of convention. It is doubtful however

Francesco Guala

17

Genitourinary medicine and surgery in Nelson's navy  

PubMed Central

Surgeons of the Royal Navy during the Napoleonic and revolutionary wars, between 1793 and 1815, were solely responsible for all health care of the officers, men, and boys of their ships. This paper examines the genitourinary medicine and surgery encountered by the naval surgeons at the time of Nelson. Primary sources are examined to explore the presentation, case mix, and management of genitourinary disease during this period. A general overview is given of the life and work of the Royal Naval surgeons at the end of the 18th century. The documents that were examined contained 39 surgeon's journals, these were written by 26 surgeons on 13 different ships. The journals contained 446 presentations to the sick list of men with genitourinary symptoms. The presenting symptoms are grouped together under the following headings; venereal disease, penile pathology, scrotal pain and swelling, urinary symptoms and retention, stone disease and trauma. Examination of these journals permits a glimpse of medical life in the Royal Navy during the time of Nelson. The case load and management of genitourinary disease shows the diversity of presentation to these surgeons.

Goddard, J

2005-01-01

18

The Nelson A. Rockefeller Institute of Government  

NSDL National Science Digital Library

Created to honor the work and legacy of the late Nelson A. Rockefeller, the Nelson A. Rockefeller Institute of Government is dedicated to enhancing "the capabilities of state governments and the federal system to deal effectively with the nation's domestic challenges." Based at the University at Albany, State University of New York, the Institute's website provides policy makers and others with access to research papers on everything from tax revenues to health care in the Empire State. First-time visitors won't want to miss the New York State Statistical Yearbook. This document offers a thorough portrait of economics, agriculture, education, and transportation throughout the state. Moving on, the "Research and Data" area offers working papers, briefs, and other materials on subjects including disaster recovery, faith-based social services, and intergovernmental relations. Finally, the "Forums and Events" area contains archived video and other coverage of events like "New York in the World: The Impact of the Global Economy on New York State and City."

2012-01-27

19

Nelson`s syndrome associated with a somatic frame shift mutation in the glucocorticoid recepter gene  

SciTech Connect

Nelson`s syndrome is the appearance and/or progression of ACTH-secreting pituitary macroadenomas in patients who had previously undergone bilateral adrenalectomy for Cushing`s disease. Extremely high plasma ACTH levels and aggressive neoplastic growth might be explained by the lack of appropriate glucocorticoid negative feedback due to defective glucocorticoid signal transduction. To study the glucocorticoid receptor (GR) gene in Nelson`s syndrome, DNA was extracted from pituitary adenomas and leukocytes of four patients with this condition and amplified by PCR for direct sequence analysis. In one of the tumors, a heterozygous mutation, consisting of an insertion of a thymine between complementary DNA nucleotides 1188 and 1189, was found in exon 2. This frame-shift mutation led to premature termination at amino acid residue 366 of the world-type coding sequence, excluding the expression of a functioning receptor protein from the defective allele. The mutation was not detected in the sequence of the GR gene in the patient`s leukocyte DNA, indicating a somatic origin. By lowering the receptor number in tumorous cells, this defect might have caused local resistance to negative glucocorticoid feedback similar to that caused by the presence of a null allele in a kindred with the generalized glucocorticoid resistance syndrome. P53 protein accumulation, previously reported in 60% of corticotropinomas, could not be detected in any of the four pituitary tumors examined by immunohistochemistry. We suggest that a somatic GR defect might have played a pathophysiological role in the tumorigenesis of the corticotropinoma bearing this mutation. 35 refs., 3 figs., 1 tab.

Karl, M.; Stratakis, C.A.; Chrousos, G.P.; Katz, D.A.; Ali, I.U.; Oldfield, E.H. [National Inst. of Neurological Disorders and Stroke, Bethesda, MD (United States)] [and others

1996-01-01

20

77 FR 6863 - Proposed Collection; Comment Request for VITA/TCE Program Forms  

Federal Register 2010, 2011, 2012, 2013

...Proposed Collection; Comment Request for VITA/TCE Program Forms AGENCY: Internal Revenue...the IRS is soliciting comments concerning VITA/TCE Program Forms 14310, 8653, 8654...gov. SUPPLEMENTARY INFORMATION: Title: VITA/TCE Program Forms. OMB Number:...

2012-02-09

21

Lewy Body Dementia Research  

MedlinePLUS

... NYU Medical Center. Recent Studies Demonstrate Benefits of Cholinesterase Inhibitors in DLB 8/15/2012 - Two recent ... Lewy bodies add to the strong case for cholinesterase inhibitor (ChEI) treatment in LBD. Risk Factors Identified ...

22

1. Historic American Buildings Survey, Nelson E. Baldwin, Photographer March ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. Historic American Buildings Survey, Nelson E. Baldwin, Photographer March 20, 1937, View-Old Dutch Barn-Wemple Farm Ft. Hunter, N.Y. - Old Dutch Barn, Wemple Farm, Fort Hunter, Montgomery County, NY

23

5. Historic American Buildings Survey, Nelson E. Baldwin, Photographer April ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

5. Historic American Buildings Survey, Nelson E. Baldwin, Photographer April 7, 1937, VIEW-MANTEL IN EAST ROOM-FIRST FLOOR ANSON PRATT HOUSE, NEW CONCORD, N.Y. - Anson Pratt House, New Concord, Columbia County, NY

24

2. Historic American Buildings Survey, Nelson E. Baldwin, Photographer April ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

2. Historic American Buildings Survey, Nelson E. Baldwin, Photographer April 7, 1937, VIEW-FRONT AND SIDE ELEVATION ANSON PRATT HOUSE-NEW CONCORD, N.Y. - Anson Pratt House, New Concord, Columbia County, NY

25

2. Historic American Buildings Survey, Nelson E. Baldwin, Photographer, Jan. ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

2. Historic American Buildings Survey, Nelson E. Baldwin, Photographer, Jan. 16, 1937, View-South West Elevation-Case Homestead No. Guilderland, Albany County, N Y. - Case Homestead, Guilderland, Albany County, NY

26

3. Historic American Buildings Survey, Nelson E. Baldwin, Photographer, Jan. ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

3. Historic American Buildings Survey, Nelson E. Baldwin, Photographer, Jan. 16, 1937, View-Second Floor Fireplace-Case Homestead No. Guilderland, Albany County, N Y. - Case Homestead, Guilderland, Albany County, NY

27

1. Historic American Buildings Survey, Nelson E. Baldwin, Photographer, Jan. ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. Historic American Buildings Survey, Nelson E. Baldwin, Photographer, Jan. 16, 1937, View-North East Elevation-Case Homestead No. Guilderland, Albany County, N Y. - Case Homestead, Guilderland, Albany County, NY

28

Benitez-Nelson Receives 2006 Ocean Sciences Early Career Award  

NASA Astrophysics Data System (ADS)

Claudia Benitez-Nelson received the AGU Ocean Sciences Early Career Award at the 2006 AGU Fall Meeting in San Francisco, Calif., in recognition of significant contributions to and promise in the ocean sciences.

Thunell, Robert; Benitez-Nelson, Claudia

2007-03-01

29

MEMORANDUM Date: April 8, 2009 From: Robert M. Nelson ...  

Center for Biologics Evaluation and Research (CBER)

Text Version... Date: April 8, 2009 From: Robert M. Nelson, MD, Ph.D. Pediatric Ethicist, Office of Pediatric Therapeutics Office of the Commissioner ... More results from www.fda.gov/downloads/advisorycommittees/committeesmeetingmaterials

30

4. Historic American Buildings Survey, Nelson E. Baldwin, Photographer August ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

4. Historic American Buildings Survey, Nelson E. Baldwin, Photographer August 5, 1936, INTERIOR VIEW-SHOWING DETAILS STAIR CASE. - General Cochrane House, State Route 5, Nelliston, Montgomery County, NY

31

4. Historic American Buildings Survey, Nelson E. Baldwin, Photographer April ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

4. Historic American Buildings Survey, Nelson E. Baldwin, Photographer April 30, 1936, VIEW-OLD KITCHEN FIREPLACE AND OVEN, RICE HOMESTEAD, RICEVILLE, N.Y. - Rice Homestead, Route 30, Mayfield, Fulton County, NY

32

2. Historic American Buildings Survey, Nelson E. Baldwin, Photographer April ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

2. Historic American Buildings Survey, Nelson E. Baldwin, Photographer April 30, 1936, VIEW-REAR AND SIDE ELEVATIONS, RICE HOMESTEAD, RICEVILLE, N Y. - Rice Homestead, Route 30, Mayfield, Fulton County, NY

33

1. Historic American Buildings Survey, Nelson E. Baldwin, Photographer April ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. Historic American Buildings Survey, Nelson E. Baldwin, Photographer April 30, 1937, VIEW-FRONT ELEVATION AND SIDE, RICE HOMESTEAD, RICEVILLE, N.Y. - Rice Homestead, Route 30, Mayfield, Fulton County, NY

34

12. Historic American Buildings Survey, Nelson E. Baldwin, Photographer Dec. ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

12. Historic American Buildings Survey, Nelson E. Baldwin, Photographer Dec. 1936, (H) INTERIOR, LOOKING NORTH WEST FROM BALCONY. - Dutch Reformed Church, State Route 10, Stone Arabia, Montgomery County, NY

35

1. Historic American Buildings Survey, Nelson E. Baldwin, Photographer March ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. Historic American Buildings Survey, Nelson E. Baldwin, Photographer March 31, 1936, VIEW-FRONT ELEVATION VAN WIE HOME, INDIAN CASTLE, HERKIMER COUNTY, N.Y. - Van Wie House, Indian Castle, Herkimer County, NY

36

ChemTeacher: Lewis Theory  

NSDL National Science Digital Library

ChemTeacher compiles background information, videos, articles, demonstrations, worksheets and activities for high school teachers to use in their classrooms. The Lewis Theory page includes resources for teaching students about the Lewis theory of acids and bases.

2011-01-01

37

Motor and cognitive function in Lewy body dementia: comparison with Alzheimer's and Parkinson's diseases.  

PubMed Central

OBJECTIVE: Motor and cognitive function were compared in patients with Lewy body dementia, Parkinson's disease, or Alzheimer's disease, to identify features that may be clinically useful in differentiating Lewy body dementia from Alzheimer's disease and Parkinson's disease. METHODS: A range of neuropsychological function and extrapyrimidal signs (EPS) was assessed in 16 patients with Lewy body dementia, 15 with Parkinson's disease, 25 with Alzheimer's disease, and 22 control subjects. RESULTS: The severity of total motor disability scores increased in the following order: controls approximately = Alzheimer's disease << Parkinson's disease < Lewy body dementia. Compared with patients with Parkinson's disease, patients with Lewy body dementia had greater scores for rigidity and deficits in the finger tapping test, but rest tremor and left/right asymmetry in EPS were more evident in Parkinson's disease. Patients with Lewy body dementia were also less likely to present with left/right asymmetry in EPS at the onset of their parkinsonism. "Sensitivity" to neuroleptic drugs was noted in 33% of patients with Lewy body dementia. Alzheimer's disease and Lewy body dementia groups had greater severity of dementia compared with the Parkinson's disease group and controls. Neuropsychological evaluation disclosed severe but similar degrees of impaired performances in tests of attention (digit span), frontal lobe function (verbal fluency, category, and Nelson card sort test) and motor sequencing in both Lewy body dementia and Alzheimer's disease groups, than Parkinson's disease and controls. In the clock face test, improved performance was noted in the "copy" compared to "draw" part of the test in controls, patients with Alzheimer's disease, and those with Parkinson's disease, but not in the patients with Lewy body dementia, who achieved equally poor scores in both parts of the test. CONCLUSIONS: EPS in Lewy body dementia resemble those seen in idiopathic Parkinson's disease, although less rest tremor and left/right asymmetry but more severe rigidity favours a diagnosis of Lewy body dementia. The unique profile of patients with Lewy body dementia seen in the clock face test suggests that this simple and easy to administer test may be useful in the clinical setting to differentiate Lewy body dementia and Alzheimer's disease. Images

Gnanalingham, K K; Byrne, E J; Thornton, A; Sambrook, M A; Bannister, P

1997-01-01

38

Diffuse lewy body disease  

Microsoft Academic Search

Opinion statement  \\u000a \\u000a \\u000a \\u000a \\u000a – \\u000a \\u000a •Diffuse Lewy body disease (DLB) is a neurodegenerative disorder characterized by dementia, fluctuations in mental status,\\u000a hallucinations, and parkinsonism. Diffuse Lewy body disease is the second most common cause of dementia, following Alzheimer’s\\u000a disease. The treatment of DLB includes cholinergic therapy for cognitive impairment, atypical neuroleptics to alleviate hallucinations,\\u000a and levodopa\\/carbidopa to improve parkinsonism.\\u000a \\u000a \\u000a \\u000a \\u000a – \\u000a \\u000a •The recognition

Theresa A. Zesiewicz; Matthew J. Baker; Peter B. Dunne; Robert A. Hauser

2001-01-01

39

Dementia with Lewy bodies  

PubMed Central

Synopsis The advent of new immunostains have improved our ability to detect limbic and cortical Lewy bodies, and it is now evident that Dementa with Lewy bodies (DLB) is the second most common neurodegenerative dementia, after Alzheimer’s disease (AD). Distinguishing DLB from AD has important implications for treatment, in terms of substances that may worsen symptoms (i.e., anticholinergic and certain neuroleptic medications) and those that may improve them (i.e., cholinesterase inhibitors, carbidopa-levodopa). Neurocognitive patterns, psychiatric features, extrapyramidal signs and sleep disturbance are helpful in differentiating DLB from AD early in the disease course. Differences in the severity of cholinergic depletion as well as type and distribution of neuropathology contribute to these clinical differences, though DLB patients with a high density of co-occuring AD pathology are less clinical distinguishable from AD.

Ferman, Tanis J.; Boeve, Bradley F.

2009-01-01

40

Lewis and Clark  

NSDL National Science Digital Library

The student will learn to use the module tutorial, identifying the query, measuring, eraser, information, and magnifying tools, as well as the layers on the web based Lewis and Clark Map. This lesson will be a part of a larger unit on mapping and creating a âÂÂtravel brochureâÂÂ/ atlas within a history class. This lesson will be used for one class period. This resource includes both a teaching guide and student worksheets.

Bandow, Cindy

2011-09-14

41

Radical frustrated lewis pairs.  

PubMed

While a growing body of literature describes FLP adducts of diamagnetic unsaturated substrates such as alkenes, alkynes and heterocumulenes such as carbon dioxide, capture of the diatomic radical nitric oxide (NO) by intramolecular phosphane/borane FLPs gives a new family of radical frustrated Lewis pair adducts. Capture of NO results in heterocycles with new P-N and B-N bonds featuring a spin density Umpolung of NO to give FLP-NO species that possess significant O-centered radical reactivity. Use of these radical FLP-NO species in C-H functionalization chemistry via H-atom abstraction / radical recombination sequences as well as deployment in nitroxide mediated polymerization of alkenes indicates a rich and diverse chemistry for FLP-NO species. An alternative, complementary strategy to generate radical FLPs involves the use of transition metal centers with unpaired electrons as the Lewis acid component of an FLP in conjunction with a tethered but hindered Lewis base. PMID:23468284

Warren, Timothy H; Erker, Gerhard

2013-01-01

42

Removal of UV Cutoff for the Nelson Model with Variable Coefficients  

NASA Astrophysics Data System (ADS)

We consider the Nelson model with variable coefficients. Nelson models with variable coefficients arise when one replaces in the usual Nelson model the flat Minkowski metric by a static metric, allowing also the boson mass to depend on position. We study the removal of the ultraviolet cutoff.

Gérard, Christian; Hiroshima, Fumio; Panati, Annalisa; Suzuki, Akito

2012-09-01

43

John Nelson Darby: Scholarship that Influenced the Bible College Movement  

Microsoft Academic Search

The study reported in this article focused on the scholastic life of John Nelson Darby and his contributions to the Bible college movement. Darby continues to exert a great influence on Christianity, particularly conservative evangelical Christianity. This research provides a discussion of the forces that conspired to shape the direction of Darby's life. It also discusses the influence his ideas

Winston Terrance Sutherland

2010-01-01

44

1. Historic American Buildings Survey, Nelson E. Baldwin, Photographer Jan. ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. Historic American Buildings Survey, Nelson E. Baldwin, Photographer Jan. 16, 1937, View-Proper House-South of Hudson, Township of Livingston-(See back of photograph for description). - Livingston House, State Route 9E, Livingston Township, Hudson, Columbia County, NY

45

Analyticity of the Ground State Energy for Massless Nelson Models  

NASA Astrophysics Data System (ADS)

We show that the ground state energy of the translationally invariant Nelson model, describing a particle coupled to a relativistic field of massless bosons, is an analytic function of the coupling constant and the total momentum. We derive an explicit expression for the ground state energy which is used to determine the effective mass.

Abdesselam, Abdelmalek; Hasler, David

2012-03-01

46

John Nelson Darby: His Contributions to Evangelical Christian Higher Education  

ERIC Educational Resources Information Center

|The study reported in this article focused on the contributions of John Nelson Derby to biblical hermeneutics and contemporary eschatological thought. Darby continues to exert a great influence on Christianity, particularly conservative evangelical Christianity. This research provides a discussion of Darby's contributions to contemporary…

Sutherland, Winston Terrance

2010-01-01

47

Nelson River HVDC system Y2k issues  

Microsoft Academic Search

The Nelson River HVDC system consists of two bipoles and supplies 70% of Manitoba Hydro's total power. Manitoba Hydro appointed a Y2K Contingency Planning Working Group and two Task Forces, one for the Power Systems and Operations and the other for the business systems. The function of the Power Systems and Operations Task Force is to test all the equipment

N. S. Dhaliwal; L. G. Crowe

1999-01-01

48

2. Historic American Buildings Survey, Nelson E. Baldwin, Photographer, Jan. ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

2. Historic American Buildings Survey, Nelson E. Baldwin, Photographer, Jan. 16, 1937, View - Interior Door Opening into Apartment on First Floor, 123 North Pearl St., Albany, N.Y. - Old Homeopathic Hospital (Interiors), 123 North Pearl Street, Albany, Albany County, NY

49

3. Historic American Buildings Survey, Nelson E. Baldwin, Photographer, Jan. ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

3. Historic American Buildings Survey, Nelson E. Baldwin, Photographer, Jan. 16, 1937, View - Double Doors and Columns in Apartment on First Floor, 123 North Pearl St., Albany, N.Y. - Old Homeopathic Hospital (Interiors), 123 North Pearl Street, Albany, Albany County, NY

50

4. Historic American Buildings Survey, Nelson E. Baldwin, Photographer, Jan. ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

4. Historic American Buildings Survey, Nelson E. Baldwin, Photographer, Jan. 16, 1937, View - Second to Third Floor Stairs Old Homeopathic Hospital, 123 North Pearl St., Albany, N.Y. - Old Homeopathic Hospital (Interiors), 123 North Pearl Street, Albany, Albany County, NY

51

1. Historic American Buildings Survey, Nelson E. Baldwin, Photographer, Jan. ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. Historic American Buildings Survey, Nelson E. Baldwin, Photographer, Jan. 16, 1937, View - Stairway from First to Second Floor Old Homeopathic Hospital (Office of the HABS), Albany, N.Y. - Old Homeopathic Hospital (Interiors), 123 North Pearl Street, Albany, Albany County, NY

52

John Nelson Darby: Scholarship that Influenced the Bible College Movement  

ERIC Educational Resources Information Center

|The study reported in this article focused on the scholastic life of John Nelson Darby and his contributions to the Bible college movement. Darby continues to exert a great influence on Christianity, particularly conservative evangelical Christianity. This research provides a discussion of the forces that conspired to shape the direction of…

Sutherland, Winston Terrance

2010-01-01

53

Carl L. Nelson: The Interrogator (1910–2007)  

Microsoft Academic Search

During the 1940s–1970s, Carl Nelson was an imposing figure, literally and figuratively, in American academic accounting. With high expectations for his students, he taught several generations of accountants, practitioners, and professors. He made accounting exciting and provocative by encouraging his students to critique GAAP, to explore alternatives to conventional accounting wisdom, and to search for substance in transactions regardless of

Robert Bloom

2009-01-01

54

Silenced but Not Silent: The Rhetorical Influence of Nelson Mandela.  

ERIC Educational Resources Information Center

In the epicenter of the political strife in South Africa is former African National Congress (ANC) leader Nelson Mandela. The ANC is considered to be the leading source of opposition to white rule in South Africa, and Mandela is one of the most revered and powerful figures to emerge from that organization. Incarcerated for over 25 years on charges…

Boyd, Susy

55

The Lewis Walpole Library  

NSDL National Science Digital Library

The Lewis Walpole Library at Yale contains a myriad of materials, the majority of which are English caricatures and political satirical prints from the 17th to 19th centuries. The artists of these cheeky works include Woodward, Hogarth, Cruikshank, Bunbury, and Newton. The collection includes items from Walpole's personal library, such as the "Cries of London," trade cards, invitations, and bookplates. Theater lovers will appreciate the volumes of playbills from theaters in Bath and Exeter. One of the more recent additions is the scrapbook of drawings which belonged to Richard Bull, which features watercolors of insects, reptiles, and fish.

2010-01-01

56

International E-vita open registry  

PubMed Central

The E-vita open hybrid stent-graft enables successful one-stage repairs of complex pathologies of the ascending aorta, aortic arch, and descending aorta. To evaluate the efficacy and durability of this treatment concept, the International E-vita open registry (IEOR) was initiated in 2008. 416 patients from 10 European centers were recruited, separated into 138 (33.2%) acute dissection cases, 142 (34.1%) chronic dissection cases, and 136 (32.7%) patients with multisegmental thoracic aneurysmal disease. In-hospital mortality was 16%, 14%, and 13% for each of the three groups, respectively, and stroke and spinal cord injury rates ranged between 5-7% and 3-9%. Survival after 5 years was 79%, 86%, and 78% for acute dissection, chronic dissection, and multisegmental aneurysmal patients, with freedom from open aortic surgery after 5 years at 96%, 94% and 82%. Findings from IEOR demonstrate the importance of the registry as an important tool for developing guidelines and frameworks in the management of this complex pathology.

Tsagakis, Konstantinos

2013-01-01

57

Exploring with Lewis and Clark  

NSDL National Science Digital Library

You will research the Expedition of Lewis and Clark using the websites provided. From there you will answer the three questions listed and come up with three of your own. Directions You are going to be a exploring with Lewis and Clark on their journey out west. Research the expedition using the sites that have been ...

Zuniga, Miss

2011-07-13

58

Quantum mechanical states as attractors for Nelson processes  

NASA Astrophysics Data System (ADS)

In this paper we reconsider, in the light of the Nelson stochastic mechanics, the idea originally proposed by Bohm and Vigier that arbitrary solutions of the evolution equation for the probability densities always relax in time toward the quantum mechanical density ¦?¦2 derived from the Schrödinger equation. The analysis of a few general propositions and of some physical examples show that the choice of the L1 metrics and of the Nelson stochastic flux is correct for a particular class of quantum states, but cannot be adopted in general. This indicates that the question if the quantum mechanical densities attract other solution of the classical Fokker-Planck equations associated to the Schrödinger equation is physically meaningful, even if a classical probabilistic model good for every quantum stale is still not available. A few suggestion in this direction are finally discussed.

Petroni, Nicola Cufaro; Guerra, Francesco

1995-02-01

59

Jacques Derrida meets Nelson Mandela: archival ethics at the endgame  

Microsoft Academic Search

Verne Harris offers a reflection on legacy and the archive through three intersecting enquiries, on: the South African tradition\\u000a of ‘archives for justice’, deconstruction’s insistence that the work of archives is justice; and the legacies of Nelson Mandela\\u000a and Jacques Derrida. He makes a case for an open-ended making and re-making of legacy and for a more radically transformative\\u000a agenda

Verne Harris

2011-01-01

60

Meriwether Lewis: was it suicide?  

PubMed

Even 200 years following the conclusion of the Lewis and Clark Expedition, questions remain about whether Meriwether Lewis' death was a suicide. The purpose of this article is to consider this issue by examining historical evidence from a psychological perspective. A risk factor model for suicide assessment (Sanchez, 2001) is employed to evaluate the nature of Lewis' historical, personal, psychosocial environmental, and clinical risk factors as well as protective factors. The authors conclude that though there is some evidence to support a theory of murder, Lewis was at a high suicide risk at the time of his death, and that the preponderance of the evidence indicates that he died by his own hand. PMID:15385176

Westefeld, John S; Less, Aaron

2004-01-01

61

Infrared Problem for the Nelson Model on Static Space-Times  

NASA Astrophysics Data System (ADS)

We consider the Nelson model on some static space-times and investigate the problem of existence of a ground state. Nelson models with variable coefficients arise when one replaces in the usual Nelson model the flat Minkowski metric by a static metric, allowing also the boson mass to depend on position. We investigate the existence of a ground state of the Hamiltonian in the presence of the infrared problem, i.e. assuming that the boson mass m( x) tends to 0 at spatial infinity. We show that if m( x) ? C | x|-1 at infinity for some C > 0 then the Nelson Hamiltonian has a ground state.

Gérard, Christian; Hiroshima, Fumio; Panati, Annalisa; Suzuki, Akito

2011-12-01

62

77 FR 1667 - Nelson S. Galgoul, Av. Edison Passess 909, Rio De Janeiro, R.J., Brazil 20531-070, Respondent...  

Federal Register 2010, 2011, 2012, 2013

...COMMERCE Bureau of Industry and Security Nelson S. Galgoul, Av. Edison Passess 909...20531-070, Respondent; Order Relating to Nelson S. Galgoul The Bureau of Industry and...Commerce (``BIS''), has notified Nelson S. Galgoul (``Galgoul'') of...

2012-01-11

63

Rutherford's curriculum vitae, 1894-1907.  

PubMed

A single page, handwritten document was discovered when the Macdonald Physics building of McGill University in Montreal was gutted in 1978. This proved to be the draft of Ernest Rutherford's curriculum vitae (C.V.) covering the years 1894-1907, probably written in the autumn of 1906 when Rutherford was preparing to leave McGill. The C.V. contains 21 headings in chronological order, referring to research and other activities of Rutherford and his coauthors (especially Soddy and Barnes), plus a further set of headings relating to the associated investigations of Rutherford's team, including Eve and Hahn. A transcript of the document is provided, although in several places, Rutherford's handwriting is difficult to interpret, and the significance of his abbreviations is not always clear. Each of the items in the C.V. is discussed briefly in this review, in the light both of Rutherford's personal career and of the contribution of his team to the development and understanding of radioactivity. This contribution included the cause and nature of radioactivity (with Soddy), energy aspects of radioactive decay (with Barnes), elucidation of the uranium-radium, thorium and actinium series (Godlewski and Hahn), the radioactivity of the earth and atmosphere (Eve), the nature of the gamma rays (Eve) and, perhaps most important of all, the nature and properties of the alpha particle (Rutherford himself). The latter investigations led directly to Rutherford's later work in Manchester, including the nuclear model of the atom and artificial disintegration of the nucleus. PMID:7565376

Cohen, M

1995-06-01

64

“Buses Are a Comin’. Oh Yeah!”: Stanley Nelson on Freedom Riders  

Microsoft Academic Search

: This conversation with the prominent filmmaker Stanley Nelson engages with Freedom Riders, his most recent feature-length documentary, which aired on the American Experience (PBS) during the fiftieth anniversary of the Freedom Rides—a nonviolent protest movement that in 1961 challenged Jim Crow laws and practice in the Deep South. In it, Nelson elaborates on the Freedom Riders’ tribulations and triumph,

Michael T. Martin

2011-01-01

65

“Buses Are a Comin’. Oh Yeah!”: Stanley Nelson on Freedom Riders  

Microsoft Academic Search

This conversation with the prominent filmmaker Stanley Nelson engages with Freedom Riders, his most recent feature-length documentary, which aired on the American Experience (PBS) during the fiftieth anniversary of the Freedom Rides—a nonviolent protest movement that in 1961 challenged Jim Crow laws and practice in the Deep South. In it, Nelson elaborates on the Freedom Riders’ tribulations and triumph, the

Michael T. Martin

2011-01-01

66

78 FR 56224 - Hydro Nelson, Ltd.; Hydro-WM, LLC; Notice of Transfer of Exemption  

Federal Register 2010, 2011, 2012, 2013

...Energy Regulatory Commission [Project No. 3401-049] Hydro Nelson, Ltd.; Hydro-WM, LLC; Notice of Transfer of Exemption...Hydro-WM, LLC. The project is located on the Rockfish River in Nelson County, Virginia. The transfer of an exemption does not...

2013-09-12

67

Rationalization, Transformations of Consciousness and Intercivilizational EncountersReflections on Benjamin Nelson's Sociology of Civilizations  

Microsoft Academic Search

This article provides a critical reconstruction of Benjamin Nelson's work on the sociology of civilizations. His main concepts for civilizational analysis are located within the sociological tradition, in particular, the work of Durkheim, Mauss and their school and Max Weber. The article focuses especially on the historical, comparative and analytic value of Nelson's distinction among three types of structures of

Donald A. Nielsen

2001-01-01

68

A Theoretically Consistent Version of the Nelson and Siegel Class of Yield Curve Models  

Microsoft Academic Search

A popular class of yield curve models is based on the Nelson and Siegel approach of ‘fitting’ yield curve data with simple functions of maturity. However, such models cannot be consistent across time. This article addresses that deficiency by deriving an intertemporally consistent and arbitrage?free version of the Nelson and Siegel model. Adding this theoretical consistency expands the potential applications

Leo Krippner

2006-01-01

69

Moral Realism and Program Explanation: A Very Short Symposium 1: Reply to Nelson  

Microsoft Academic Search

In chapter 8 of Miller 2003, I argued against the idea that Jackson and Pettit's notion of program explanation might help Sturgeon's non-reductive naturalist version of moral realism respond to the explanatory challenge posed by Harman. In a recent paper in the AJP[Nelson 2006, Mark Nelson has attempted to defend the idea that program explanation might prove useful to Sturgeon

Alexander Miller

2009-01-01

70

77 FR 42327 - Proposed Supplementary Rules for the Morley Nelson Snake River Birds of Prey National...  

Federal Register 2010, 2011, 2012, 2013

...Rules for the Morley Nelson Snake River Birds of Prey National Conservation Area AGENCY...700-acre Morley Nelson Snake River Birds of Prey National Conservation Area (NCA...Record of Decision (ROD). The Snake River Birds of Prey NCA RMP identifies...

2012-07-18

71

Part of the Solution: Judy Nelson--Pierce County Library System, Tacoma  

ERIC Educational Resources Information Center

|Judy Nelson thinks it's important to understand what the community wants for its young people, "which means lots of listening." We need to give taxpayers more good reasons to support libraries, she says, and the community's problems and unmet needs are opportunities for libraries to be an integral part of the solution. One problem Nelson turned…

Library Journal, 2005

2005-01-01

72

The Lewis Acidity of Diboron Tetrafluoride.  

National Technical Information Service (NTIS)

The stability of Lewis acid-base adducts of diboron tetrafluoride, boron trifluoride, and boron trichloride with various bases, and acid displacement reactions of the complexes are reported. It has been confirmed that boron trichloride is a stronger Lewis...

J. D. Hansen T. D. Parsons

1965-01-01

73

Ultrastructure of Lewy bodies in the stellate ganglion  

Microsoft Academic Search

The Lewy body, a characteristic nerve cell inclusion in idiopathic parkinsonism, was examined by electron microscopy in the stellate ganglion, obtained from 9 patients at autopsy. Three main forms of Lewy bodies or Lewy body-related structures were demonstrated: A. Rare filamentous Lewy bodies, similar to Lewy bodies in the central nervous system. B. Granular Lewy bodies in nerve cell processes.

Lysia S. Forno; Roxana L. Norville

1976-01-01

74

Lewis Acidity of LiF.  

National Technical Information Service (NTIS)

Based on the recently developed pF Lewis acidity scale,' free gaseous LiF is a surprisingly strong Lewis acid, comparable to SiF4. It was therefore of interest to study whether a strong Lewis base, such as CsF, could transfer a fluoride ion to LiF with fo...

V. Vij J. A. Boatz F. Tham A. Vij K. O. Christe

2000-01-01

75

Evaluating Faculty Development Outcomes by Using Curriculum Vitae Analysis  

Microsoft Academic Search

Background and Objectives: Many faculty development (FD) programs depend on external private and public sponsors that routinely require systematic studies on FD outcomes. The results of evalua- tion studies can influence whether or not programs continue to be funded. To better evaluate program outcomes on academic productivity, this paper presents and illustrates an evaluation method that uses the curricula vitae

Jeffrey A. Morzinski; David B. Schubot

76

Lewis & Clark: An Interdisciplinary Expedition  

ERIC Educational Resources Information Center

|On January 18, 1803 President Thomas Jefferson asked Congress to fund an expedition to the source of the Missouri River. This expedition would become known as the Corps of Discovery, which would spend twenty-eight months exploring, studying, and documenting the wonders of the western frontier. Led by Captains Meriwether Lewis and William Clark,…

Brugar, Kristy

2004-01-01

77

Lewis and Clark as Naturalists.  

ERIC Educational Resources Information Center

|Intended for use in elementary and high school education, this Web site includes a teacher's guide and three lesson plans. The site contains images of museum specimens, scientific drawings, and field photos of the plant and animal species observed by Meriwether Lewis and William Clark, along with journal excerpts, historical notes, and references…

Smithsonian Institution, Washington, DC. National Museum of Natural History.

78

Classical limit of the Nelson model with cutoff  

NASA Astrophysics Data System (ADS)

In this paper we analyze the classical limit of the Nelson model with cutoff, when both non-relativistic and relativistic particles number goes to infinity. We prove convergence of quantum observables to the solutions of classical equations, and find the evolution of quantum fluctuations around the classical solution. Furthermore, we analyze the convergence of transition amplitudes of normal ordered products of creation and annihilation operators between different types of initial states. In particular, the limit of normal ordered products between states with a fixed number of both relativistic and non-relativistic particles yields an unexpected quantum residue: instead of the product of classical solutions we obtain an average of the product of solutions corresponding to varying initial conditions.

Falconi, Marco

2013-01-01

79

Nelson Mandela Urges Action on Growing TB and HIV Epidemic  

NSDL National Science Digital Library

Well respected for his fervent devotion to human rights, Nobel laureate Nelson Mandela urged cooperation and immediate action in the global struggle against tuberculosis, a situation which is extremely acute in parts of the developing world. In his remarks, Mandela also related the struggle with tuberculosis to the situation with preventing the spread of HIV. Speaking to reporters at an international conference in Bangkok, Mandela remarked that "We cannot win the battle against AIDS if we do not also fight TB. TB is too often a death sentence for people with AIDS. It does not have to be this way." Mandela knows all too well about the situation with TB, as he himself contracted the disease during his time as a political prisoner in South Africa during apartheid. Research into the dual tuberculosis and AIDS epidemic received a large infusion of funding this Thursday as the Bill and Melinda Gates Foundation announced that the organization would offer $45 million for studies into strategies to control TB in areas with high HIV infection rates. Specifically, the monies will go to pay for three large-scale community studies in Africa and South American over seven years.The first link will take visitors to an article from the Voice of America, complete with an audio report from reporter Steve Baragona reporting from Bangkok on the XV International AIDS Conference. The second link leads to an article from the Sydney Morning Herald that talks about the recent grant offered by the Gates Foundation to the Global Fund on AIDS. The third link leads to the homepage of the Center for TB Research Laboratory at Johns Hopkins University where visitors can read about the lab's work and learn about the need for additional research into this disease. The fourth link leads visitors to the Stop TB Partnership webpage, which is hosted by the World Health Organization. Visitors may want to peruse some of the helpful publications, such as reports on global tuberculosis control and the event calendar. The fifth link leads to the homepage for the XV International AIDS Conference, which features full coverage of the conference in Bangkok, video coverage of the various sessions, and updated news from the conference. The final link leads to a rather intriguing five-part radio series on the life and times of Nelson Mandela, sponsored by the American Radio Works. The remarkable highlights of this series include interviews with former African National Congress activists, fellow Robben Island prisoners, and a rare recording of the 1964 trial where Mandela was sentenced to life in prison.

80

Application of an Improved Nelson-Nguyen Analysis to Eccentric, Arbitrary Profile Liquid Annular Seals.  

National Technical Information Service (NTIS)

An improved dynamic analysis for liquid annular seals with arbitrary profile based on a method, first proposed by Nelson and Nguyen, is presented. An improved first order solution that incorporates a continuous interpolation of perturbed quantities in the...

S. Padavala A. B. Palazzolo P. Vallely S. Ryan

1994-01-01

81

1. Historic American Buildings Survey Nelson E. Baldwin, Photographer ViewHoucks ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. Historic American Buildings Survey Nelson E. Baldwin, Photographer View-Houcks Hall-Houcks Corners, Albany County, N.Y. Jan. 16, 1937. - Old Tavern, Feura Bush Vicinity, Houcks Corners, Albany County, NY

82

8. Historic American Buildings Survey (Fed.) Nov. 9,1936, Nelson E. ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

8. Historic American Buildings Survey (Fed.) Nov. 9,1936, Nelson E. Baldwin, Photographer, (K) EXTERIOR, GENERAL VIEW OF HOUSE AND BLOCKHOUSE, FROM SOUTH EAST. - Johnson Hall, Johnstown, Fulton County, NY

83

Molecular Pathology of Lewy Body Diseases  

PubMed Central

Lewy body diseases are characterized by the presence of Lewy bodies, alpha-synuclein(AS)-positive inclusions in the brain. Since their main component is conformationally modified AS, aggregation of the latter is thought to be a key pathogenic event in these diseases. The analysis of inclusion body constituents gives additional information about pathways also involved in the pathology of synucleinopathies. Widespread mitochondrial dysfunction is very closely related to disease development. The impairment of protein degradation pathways, including both the ubiquitin-proteasome system and the autophagy-lysosome pathway also play an important role during the development of Lewy body diseases. Finally, differential expression changes of isoforms corresponding to genes primarily involved in Lewy body formation point to alternative splicing as another important mechanism in the development of Parkinson’s disease, as well as dementia with Lewy bodies. The present paper attempts to give an overview of recent molecular findings related to the pathogenesis of Lewy body diseases.

Beyer, Katrin; Domingo-Sabat, Montserrat; Ariza, Aurelio

2009-01-01

84

CRCHD - CRCHD Research - Principal Investigator: William G. Nelson, M.D., Ph.D.  

Cancer.gov

Dr. William G. Nelson is a Professor of Oncology, Urology, Pharmacology, Medicine, Pathology, and Radiation Oncology at the Johns Hopkins University School of Medicine, with a Joint Appointment in Environmental Health Sciences at the Johns Hopkins University Bloomberg School of Public Health. Dr. Nelson serves as the Marion I. Knott Professor and Chairman of Oncology and the Director of the Sidney Kimmel Comprehensive Cancer Center.

85

Forecasting the term structures of Treasury and corporate yields using dynamic Nelson-Siegel models  

Microsoft Academic Search

We extend Diebold and Li’s dynamic Nelson-Siegel three-factor model to a broader empirical prospective by including the evaluation of the state space approach and by using nine different ratings for corporate bonds. We find that the dynamic Nelson-Siegel factor AR(1) model outperforms other competitors on the out-of-sample forecast accuracy, especially on the investment-grade bonds for the short-term forecast horizon and

Wei-Choun Yu; Eric Zivot

2011-01-01

86

Forecasting the Term Structures of Treasury and Corporate Yields: Dynamic Nelson-Siegel Models Evaluation  

Microsoft Academic Search

Abstract We extend Diebold and Li’s dynamic,Nelson-Siegel three-factor model to a broader empirical prospective by including the evaluation of state-space approach, and using nine different ratings for corporate bonds. We find that the dynamic,Nelson-Siegel factor AR(1) model outperforms other competitors on the out-of-sample forecast accuracy, especially on the investment-grade bonds in the short-term forecast horizon and on the high-yield bonds

Wei-choun Yu; Eric Zivot

87

A Biography of Distinguished Scientist Gilbert Newton Lewis (by Edward S. Lewis)  

Microsoft Academic Search

The Edward Mellen Press: Lewiston, NY, 1998. 114 pp + index. ISBN 0-7734-8284-9. $69.95. There may not be a surname better known to students of chemistry than Lewis, from the Lewis electron-dot diagrams and the Lewis theory of acids and bases. More advanced students may know of the groundbreaking textbook Thermodynamics, by Lewis and Randall. Yet few Americans know much

1999-01-01

88

A cross-discipline survey on university students’ acceptance of Mobile Curriculum Vitae developed using Weblog  

Microsoft Academic Search

A traditional Curriculum Vitae (CV) fails to highlight the candidates’ strength, skills and achievement effectively. Thus, graduates are unable to sell and present themselves in an interactive way in order to impress the employer. In the digital age, mobile phones and Wi-Fi are ubiquitous; thus, an online CV namely “Mobile Curriculum Vitae” (m-CV) is created and proposed to be the

Boon Yih Mah; Wan Syakira Meor Hissan; Pei Eng Chng

2011-01-01

89

Lewy Body Pathology in Normal Elderly Subjects  

PubMed Central

Lewy body and Lewy neurite formation are the hallmark neuropathological findings in Parkinson’s disease (PD), Parkinson’s disease with dementia (PDD), dementia with Lewy bodies (DLB), and other alpha-synucleinopathies. They also have been described in the brains of normal older individuals and referred to as incidental Lewy body disease. The purpose of this study was to determine the prevalence of Lewy bodies and Lewy neurites (Lewy body pathology; LBP) in 139 autopsies from our normal volunteer control group of the University of Kentucky Alzheimer’s Disease Center. All subjects were followed longitudinally and were cognitively normal without any type of movement disorder, neuropsychiatric features, or other CNS findings. Thirty-three out of 139 normal subjects contained LBP in various brain regions. The most common regions involved were the medulla (26%), amygdala (24%), pons (20%), and midbrain (20%). No mean statistical differences were found between those with and without LBP on any demographic or cognitive variable, Braak stage, or neurofibrillary tangle and neuritic plaque quantitation. The high prevalence of LBP in our elderly, well educated group is not clear although it does not appear to be related to aging or the presence of AD pathology. Overall, our findings support the concept that incidental Lewy body disease most likely represents preclinical or presymptomatic PD, PDD or DLB.

Markesbery, William R.; Jicha, Gregory A.; Liu, Huaichen; Schmitt, Frederick A.

2009-01-01

90

alpha-Synuclein in Lewy bodies  

Microsoft Academic Search

Lewy bodies, a defining pathological characteristic of Parkinson's disease and dementia with Lewy bodies (DLB), constitute the second most common nerve cell pathology, after the neurofibrillary lesions of Alzheimer's disease. Their formation may cause neurodegeneration, but their biochemical composition is unknown. Neurofilaments and ubiquitin are present, but it is unclear whether they are major components of the filamentous material of

Maria Grazia Spillantini; Marie Luise Schmidt; Virginia M.-Y. Lee; John Q. Trojanowski; Ross Jakes; Michel Goedert

1997-01-01

91

Diffuse lewy body disease in Japan  

Microsoft Academic Search

Thirty-seven Japanese autopsy cases with diffuse Lewy body disease (DLBD) were reviewed from a clinicopathological viewpoint. Based on the neuropathological finding of whether or not many concomitant senile plaques (SPs) and\\/or neurofibrillary tangles (NFTs) are present, DLBD is divided into two forms: a common form and a pure form. In the common form not only numerous Lewy bodies but also

K. Kosaka

1990-01-01

92

Unruly Woman: An Interview with Helen Lewis.  

ERIC Educational Resources Information Center

Overviews the career of Helen Lewis as sociologist, social activist, teacher, writer, researcher, and mentor. Helen Lewis discusses growing up in segregated Georgia, her unorthodox approach to education, her fight for social and economic equality, her instrumental role in the development of Appalachian Studies programs, and how social activism…

Briscoe, Lori; Collins, Erica S.; Deal, Amanda; Hancock, Ron; McGraw, Kristyn; Lewis, Helen

2000-01-01

93

Fort Lewis Exceptional Family Member Program (EFMP)  

ERIC Educational Resources Information Center

|Located in the shadow of Mt. Rainier, Fort Lewis is the home of the highest per capita exceptional family member population in the Army. Ideally located on the Northwest coast of Washington State, Fort Lewis is home to the Strykers and First Brigade. Combined with its close proximity to McChord Air Force Base, the installation is ideally suited…

Hebdon, Heather

2007-01-01

94

Cation affinity numbers of Lewis bases  

PubMed Central

Summary Using selected theoretical methods the affinity of a large range of Lewis bases towards model cations has been quantified. The range of model cations includes the methyl cation as the smallest carbon-centered electrophile, the benzhydryl and trityl cations as models for electrophilic substrates encountered in Lewis base-catalyzed synthetic procedures, and the acetyl cation as a substrate model for acyl-transfer reactions. Affinities towards these cationic electrophiles are complemented by data for Lewis-base addition to Michael acceptors as prototypical neutral electrophiles.

Lindner, Christoph; Tandon, Raman; Maryasin, Boris; Larionov, Evgeny

2012-01-01

95

78 FR 23588 - Final Supplementary Rules for the Morley Nelson Snake River Birds of Prey National Conservation...  

Federal Register 2010, 2011, 2012, 2013

...Rules for the Morley Nelson Snake River Birds of Prey National Conservation Area, ID...700-acre Morley Nelson Snake River Birds of Prey National Conservation Area (NCA...Record of Decision (ROD). The Snake River Birds of Prey NCA RMP identifies...

2013-04-19

96

Making the Impossible Possible. Review of "Embracing Victory: Life Lessons in Competition and Compassion," by Mariah Burton Nelson.  

ERIC Educational Resources Information Center

|An adolescent aversion to competition helped the reviewer/marathoner appreciate Mariah Burton Nelson's "Embracing Victory: Life Lessons in Competition and Compassion" (Morrow, 1998). Nelson, a former collegiate and professional basketball player, focuses on female athletes' and nonathletes' attitudes about numerous competition-related topics.…

Lenk, Linda L.

1998-01-01

97

Investigation of Lewis acid versus Lewis base catalysis in asymmetric cyanohydrin synthesis.  

PubMed

The asymmetric addition of trimethylsilyl cyanide to aldehydes can be catalysed by Lewis acids and/or Lewis bases, which activate the aldehyde and trimethylsilyl cyanide, respectively. It is not always apparent from the structure of the catalyst whether Lewis acid or Lewis base catalysis predominates. To investigate this in the context of using salen complexes of titanium, vanadium and aluminium as catalysts, a Hammett analysis of asymmetric cyanohydrin synthesis was undertaken. When Lewis acid catalysis is dominant, a significantly positive reaction constant is observed, whereas reactions dominated by Lewis base catalysis give much smaller reaction constants. [{Ti(salen)O}(2)] was found to show the highest degree of Lewis acid catalysis, whereas two [VO(salen)X] (X=EtOSO(3) or NCS) complexes both displayed lower degrees of Lewis acid catalysis. In the case of reactions catalysed by [{Al(salen)}(2)O] and triphenylphosphine oxide, a non-linear Hammett plot was observed, which is indicative of a change in mechanism with increasing Lewis base catalysis as the carbonyl compound becomes more electron-deficient. These results suggested that the aluminium complex/triphenylphosphine oxide catalyst system should also catalyse the asymmetric addition of trimethylsilyl cyanide to ketones and this was found to be the case. PMID:20715204

North, Michael; Omedes-Pujol, Marta; Williamson, Courtney

2010-10-01

98

Creating Curriculum Vitae for Understanding People on the Web  

NASA Astrophysics Data System (ADS)

When users find information about people from the results of Web people searches, they often need to browse many obtained Web pages and check much unnecessary information. This task is time-consuming and complicates the understanding of the designated people. We investigate a method that integrates the useful information obtained from Web pages and displays them to understand people. We focus on curriculum vitae, which are widely used for understanding people. We propose a method that extracts event sentences from Web pages and displays them like a curriculum vita. The event sentence includes both time and events related to a person. Our method is based on the following: (1) extracting event sentences using heuristics and filtering them, (2) judging whether event sentences are related to a designated person by mainly using the patterns of HTML tags, (3) classifying these sentences to categories by SVM, and (4) clustering event sentences including both identical times and events. Experimental results revealed the usefulness of our proposed method.

Ueda, Hiroshi; Murakami, Harumi; Tatsumi, Shoji

99

CURRICULUM VITAE revised 5-14-13 John M. Kelso, MD ...  

Center for Biologics Evaluation and Research (CBER)

Text VersionPage 1. CURRICULUM VITAE revised 5-14-13 John M. Kelso, MD Division of Allergy, Asthma and Immunology Scripps Clinic, San Diego CA ... More results from www.fda.gov/downloads/advisorycommittees/committeesmeetingmaterials

100

What would Nelson and Plosser find had they used panel unit root tests?  

Microsoft Academic Search

In this study, we systemically apply nine recent panel unit root tests to the same 14 macroeconomic and financial series as those considered in the seminal paper by Nelson and Plosser (1982). The data covers OECD countries from 1950 to 2003. Our results clearly point out the difficulty that applied econometricians would face when they want to get a simple

Christophe Hurlin

2010-01-01

101

Shaping Influences on the Leadership of Genghis Khan, George Washington, and Nelson Mandela: Applications for Educators  

ERIC Educational Resources Information Center

|Using a prosopographical methodology this study examines common leadership influences that might have existed among Genghis Khan, George Washington, and Nelson Mandela. Shoup (2005) suggests that the following seven influences have contributed to nurturing the leadership of 12 renowned individuals: involved parents, happy childhood, formal,…

Bongila, Jean-Pierre

2011-01-01

102

Gold mineralisation in a syntectonic granite dike, Sams Creek, northwest Nelson, New Zealand  

Microsoft Academic Search

Riebeckite granite at Sams Creek, northwest Nelson, was intruded as an 8 km long dike into slate and quartzite metasediments (Wangapeka Formation) before or during deformation under greenschist facies conditions. Lamprophyre intrusion accompanied granite emplacement. Deformation after intrusion resulted in folding of metasediments on a northerly trend, and buckling of the east?striking granite and lamprophyre dikes. The intrusives were dismembered

S. J. Windle; D. Craw

1991-01-01

103

The recreational value of beaches in the Nelson Mandela Bay area, South Africa  

Microsoft Academic Search

Using beach visitation data collected via the administration of a questionnaire to 226 respondents, this paper estimates a random utility model of beach recreation. The relative value of selected attributes of beaches is estimated, and the recreational values of lost access to four Blue Flag beaches in the Nelson Mandela Bay area, namely Kings beach, Humewood beach, Hobie beach and

Mario Du Preez; Deborah Ellen Lee; Stephen Gerald Hosking

2011-01-01

104

Radical Questioning on the Long Walk to Freedom: Nelson Mandela and the Practice of Critical Reflection  

Microsoft Academic Search

Nelson Mandela's autobiography The Long Walk to Freedom describes how an iconic political activist and freedom fighter reflected on, and sometimes modified, four core assumptions at the heart of his struggle to overturn the White supremacist, minority hegemony and create a free South Africa. Critical reflection's focus is on understanding the dynamics of power (and how to manipulate these) and

Stephen Brookfield

2008-01-01

105

"Finding Useful Questions: On Bayesian Diagnosticity, Probability, Impact, and Information Gain": Correction to Nelson (2005)  

ERIC Educational Resources Information Center

|Reports an error in "Finding Useful Questions: On Bayesian Diagnosticity, Probability, Impact, and Information Gain" by Jonathan D. Nelson (Psychological Review, 2005[Oct], Vol 112[4], 979-999). In Table 13, the data should indicate that 7% of females had short hair and 93% of females had long hair. The calculations and discussion in the article…

Nelson, Jonathan D.

2007-01-01

106

Why are Beveridge-Nelson and Unobserved-Component Decompositions of GDP so Different?  

Microsoft Academic Search

Two widely used methods of decomposing GDP into trend and cycle yield starkly different results. The unobserved component approach implies smooth trend with large, persistent cycle. In contrast, the Beveridge and Nelson (1981) approach implies most of the variation is attributable to trend. This conflict has been widely noted. It should surprise us that the two approaches produce very different

Charles Nelson; Eric Zivot

2000-01-01

107

Why Are the Beveridge-Nelson and Unobserved-Components Decompositions of GDP So Different?  

Microsoft Academic Search

This paper reconciles two widely used decompositions of GDP into trend and cycle that yield starkly different results. The Beveridge-Nelson (BN) decomposition implies that a stochastic trend accounts for most of the variation in output, whereas the unobserved-components (UC) implies cyclical variation is dominant. Which is correct has broad implications for the relative importance of real versus nominal shocks. We

James C. Morley; Charles R. Nelson; Eric Zivot

2003-01-01

108

Radical Questioning on the Long Walk to Freedom: Nelson Mandela and the Practice of Critical Reflection  

ERIC Educational Resources Information Center

Nelson Mandela's autobiography "The Long Walk to Freedom" describes how an iconic political activist and freedom fighter reflected on, and sometimes modified, four core assumptions at the heart of his struggle to overturn the White supremacist, minority hegemony and create a free South Africa. Critical reflection's focus is on understanding the…

Brookfield, Stephen

2008-01-01

109

The structural geology of the Mount Burnett dolomite deposit, North-West Nelson  

Microsoft Academic Search

At Mt Burnett in the Wakamarama Range of North-west Nelson, a thick layer of dolomite is intercalated with an Ordovician carbonate sequence associated with Cambrian schists. A map and cross section are presented. Mesoscopic structures have been used to elucidate the major structures, which consist of an antiform flanked on either side by synforms. These folds are shear and\\/or flow

D. G. Bishop

1967-01-01

110

Microgravity Noncontact Temperature Requirements at NASA Lewis Research Center.  

National Technical Information Service (NTIS)

NASA Lewis Research Center is currently supporting 66 microgravity science and applications projects. The 66 projects are separated into 23 flight projects and 43 ground-based projects. The part of the NASA Lewis program dealing with flight experiments is...

G. Santoro

1989-01-01

111

Lewis Y Antigen as a Target for Breast Cancer Therapy.  

National Technical Information Service (NTIS)

The Lewis Y antigen is a breast cancer associated carbohydrate antigen. The basis of the program was to establish and utilize structural information for Lewis Y-antibody interactions to develop novel immunotherapeutics for breast cancer treatment. It is p...

T. Kieber-Emmons

1998-01-01

112

In dementia with Lewy bodies, Braak stage determines phenotype, not Lewy body distribution.  

PubMed

We used an autopsy series to determine whether the newest dementia with Lewy bodies (DLB) consensus pathologic classification correlates with premortem diagnosis of DLB. Neocortical sections from a total of 95 cases with Lewy bodies were stained with alpha-synuclein antibodies. We assigned cases according to the DLB consensus' categories and found a significant association with the premortem clinical diagnosis of DLB. Clinical diagnosis of DLB, however, depended on the presence of low Alzheimer disease pathology (by Braak staging) rather than on Lewy body distribution. PMID:17646627

Weisman, D; Cho, M; Taylor, C; Adame, A; Thal, L J; Hansen, L A

2007-07-24

113

Catholic Reflections for an Updated Donum Vitae Instruction: A New Catholic Challenge in a Post-Christian Europe  

Microsoft Academic Search

On February 22, 1987, the Congregation for the Doctrine of the Faith published the Donum Vitae Instruction. Twenty years later, on February 22, 2007, Pope Benedict XVI asked for an update of this Instruction. According to the Donum Vitae Instruction of 1987, the principle of the holiness of life imposes respect for human persons from the very beginning of human

Stéphane Bauzon

2008-01-01

114

Archaeological Investigations at Nelson Wash, Fort Irwin, California. Fort Irwin Archaeological Project Research Report Number 23. Volume 1. Revision.  

National Technical Information Service (NTIS)

The data recovery of seven early Holocene archeological sites in Nelson Wash, National Training Center, Fort Irwin, California was conducted during the summer of 1983. This report contains the description of artifacts recovered from these sites (4-SBr-496...

C. N. Warren

1991-01-01

115

Petroleum hydrocarbon contamination in Nelson Lagoon, Alaska, sampling three different matrices.  

PubMed

Polycyclic aromatic hydrocarbon (PAH) levels were measured in sediments, bivalves and semi-permeable membrane devices (SPMDs) in the relatively pristine marine environment of Nelson Lagoon, Alaska. Most PAH levels in Nelson Lagoon were low, and similar to global background concentrations. Sampling media type can significantly influence conclusions of PAH contamination in the environment. Concentration of a broad size range of PAHs was observed in the tissues of blue mussels (Mytilus edulis). SPMDs collected some two- to three-ring PAHs from the dissolved water phase, while sediments collected five- to six-ring PAHs that were likely adsorbed onto particulate matter. Benzo(a)pyrene, a potent carcinogen, was found in mussels at levels similar to more industrialized harbors in Alaska. PMID:22901960

Lance, Ellen W; Matz, Angela C; Reeves, Mari K; Verbrugge, Lori A

2012-08-14

116

Quantum cybernetics: a new perspective for Nelson's stochastic theory, nonlocality, and the Klein-Gordon equation  

NASA Astrophysics Data System (ADS)

The Klein-Gordon equation is shown to be equivalent to coupled partial differential equations for a sub-quantum Brownian movement of a ``particle'', which is both passively affected by, and actively affecting, a diffusion process of its generally nonlocal environment. This indicates circularly causal, or ``cybernetic'', relationships between ``particles'' and their surroundings. Moreover, in the relativistic domain, the original stochastic theory of Nelson is shown to hold as a limiting case only, i.e., for a vanishing quantum potential.

Grössing, Gerhard

2002-04-01

117

Large?scale trials of mating disruption of lightbrown apple moth in Nelson, New Zealand  

Microsoft Academic Search

Mating disruption of lightbrown apple moth (Epiphyas postvittana (Walker))was assessed in combination with reduced insecticide programmes covering 321 ha of trials in commercial Nelson apple (Malus domestica Borkh.) orchards from 1990\\/91 to 1993\\/94. The aim was to compare insect control and insecticide residues under a combination of reduced insecticide plus pheromone, compared to the standard insecticide programme alone, on a

D. M. Suckling; P. W. Shaw

1995-01-01

118

Positron emission tomography-computed tomography coregistration for diagnosis and intraoperative localization in recurrent nelson syndrome.  

PubMed

Recurrent pituitary disease presents unique challenges, including in some cases difficulty localizing a tumor radiographically. Here, we present the case of a patient with recurrent Nelson syndrome whose radiographic work-up was complicated by a significant parasellar metallic artifact. Positron emission tomography ultimately localized the lesion, and coregistration with computed tomography allowed for accurate intraoperative navigation. Additionally, we review a range of imaging techniques available in the evaluation of pituitary disease. PMID:23943718

Hintz, Eric B; Tomlin, Jeffery M; Chengazi, Vaseem; Vates, G Edward

2013-05-09

119

On the Lubensky-Nelson Model of Polymer Translocation through Nanopores  

NASA Astrophysics Data System (ADS)

We revisit the one-dimensional stochastic model of Lubensky and Nelson [Biophys. J 77, 1824 (1999)] for the electrically driven translocation of polynucleotides through alpha-hemolysin pores. We show that the model correctly describes two further important properties of the experimentally observed translocation time distributions, namely their spread (width) and their exponential decay. The resulting overall agreement between theoretical and experimental translocation time distributions is thus very good.

Reimann, Peter; Meyer, Andreas; Getfert, Sebastian

2012-09-01

120

[Immunoblotting for the serodiagnosis of syphilis. A candidate to replace the Nelson-Mayer test].  

PubMed

The lipid antigens used in the Bordet-Wassermann and prepared by Landsteiner and Marie for syphilis tests from 1909 to 1949 were non specific but have certain common features with the spirochete body. For more than forty years the Bordet-Wassermann reaction, associated with flocculation (Kahn) or agglutination (Kline-VDRL) was used to detect cases of tremonematosis despite frequent false positives reactions due to other infections. In 1949, the Nelson and Mayer test was introduced. This test was based on a rigorously specific reaction based on an antigen of live virulent Treponema pallidum. Culture being impossible, the strain had to be, and still is, maintained by weekly passage on rabbit testicles. These manipulations are very dangerous and the technique is difficult, being performed only in specialized laboratories. This test however made it possible to identify the specificity of lipid tests and led to the development of specific immunofluorescent reactions (FTA) in 1959 and of hemagglutination test (TPHA) in 1969. In 1980, we introduced a simple treponemic reaction (FTA or TPHA) associated with a lipid reaction (VDRL) for screening. The specificity of these tests is not however perfect and the Nelson test remains useful as a highly specific reaction. A simple test with comparable specificity was long awaited and is now available with immunoblotting as for HIV, boreliosis and pertussis, etc. We propose this new reaction to replace the Nelson test because it is specific, is sensitive early, distinguishes between IgG and IgM and is not dangerous to manipulate. We have tested it in over one hundred selected sera of CSF from subjects with recent, former or nervous syphilis as well as cases susceptible of producing false positive reactions and have concluded that immunoblotting is highly specific and sensitive. We recommend official approval of this test to replace the Nelson test. PMID:10073052

Pâris-Hamelin, A; Debruyne, M; Fustec-Isarboure, S

1999-01-01

121

a Footnote to Nelson's Interpretation of the Two-Slit Experiment  

NASA Astrophysics Data System (ADS)

We seek to complement Nelson's work on the two-slit experiment by showing that the two-slit process, whose density exhibits the characteristic interference pattern, may be obtained as the model after the beam has reached the screen by means of a variational mechanism. The one-slit process, modeling the beam before it reaches the screen, plays the role of a reference model.

Pavon, Michele

122

ABO and Lewis blood groups in reactive arthritis  

Microsoft Academic Search

In this study we evaluated secretor status in patients with reactive arthritis. Previous evidence indicates that non-secretion of ABO and Lewis blood group antigens to saliva and other secretions is associated with susceptibility to certain bacterial infections and certain diseases with suspected autoimmune etiology. Secretor status can be determined based on the Lewis phenotype. We studied ABO, Lewis and Rhesus

R. Tertti; H. Järvinen; R. Lahesmaa; U. Yli-Kerttula; A. Toivanen

1992-01-01

123

Flame Velocity of Cellular Flames at Low Lewis Numbers  

Microsoft Academic Search

The flame velocity of cellular flames at low Lewis numbers is numerically studied, based on the compressible Navier-Stokes equation including a one-step chemical reaction. The flame velocity of a cellular flame is always larger than that of a plane flame and increases as the Lewis number becomes lower. When the Lewis number is unity, the flame velocity is proportional to

SATOSHI KADOWAKI

2001-01-01

124

An Overview of Lewis Basicity and Affinity Scales  

ERIC Educational Resources Information Center

|The impossibility of establishing a universal scale of Lewis basicity does not prevent the determination of the quantitative behavior of Lewis bases, thanks to scales constructed against particular Lewis acids: BF[subscript 3], 4-FC[subscript 6]H[subscript 4]OH, I[subscript 2], Li[superscript +], Na[superscript +], K[superscript +],…

Laurence, Christian; Graton, Jerome; Gal, Jean-Francois

2011-01-01

125

Relationship between blood mercury levels and components of male song in Nelson's sparrows (Ammodramus nelsoni).  

PubMed

Mercury (Hg) adversely affects the health and behavior of exposed wildlife; however, behavioral effects remain largely unknown. Changes in avian singing behavior may affect a male's fitness because song reveals male quality and thus influences female mate choice and male territory-holding ability. Nelson's sparrows (Ammodramus nelsoni) live exclusively on salt marshes and risk high levels of Hg exposure and bioaccumulation. We recorded songs of male Nelson's sparrows at two locations with different Hg exposure to determine if total blood Hg concentration was related to song characteristics, as previously reported for other species. Males with higher blood Hg levels sang at higher maximum tonal frequency, but blood Hg and site location did not influence low tonal frequency and bout duration, contrary to predictions based on other species. Within the contaminated site, Hg levels were related to bouts per minute and gap duration, such that males at that site sang faster songs. Hg influences hormones and alters brain development, raising questions about specific effects on the brains and singing behavior of male Nelson's sparrows. PMID:22945769

McKay, Jennifer L; Maher, Christine R

2012-09-04

126

Designer Lewis acid based on molecular recognition  

Microsoft Academic Search

A Lewis acid is an excellent candidate as a proton substitute in man-made organic reactions. The observation that organoaluminum compounds immediately ignite when exposed to air, a reflection of the high affinity of aluminum for oxygen, inspired us to devise a new series of reagents based on that metal. Our goal was to engineer an artificial proton of a special

Hisashi Yamamoto; Keiji Maruoka

1993-01-01

127

Dementia with Lewy bodies and Alzheimer's disease  

Microsoft Academic Search

To investigate similarities and differences between Alzheimer's disease (AD) and dementia with Lewy bodies (DLB), we undertook a demographic analysis of 277 patients from the Kathleen Price Bryan Brain Bank with an antemortem diagnosis of probable AD. Patients with additional, possibly confounding clinical and pathologic diagnoses such as infarcts, hematomas, neoplasms, and other neurodegenerative disorders, were excluded from the analysis.

Carlyn K. Rosenberg; Thomas J. Cummings; Ann M. Saunders; Corinne Widico; Lauren M. McIntyre; Christine M. Hulette

2001-01-01

128

Celebrating the Bicentennial of Lewis and Clark  

ERIC Educational Resources Information Center

|Lewis, Clark, and the Corps of Discovery traveled westward from 1803 to 1806; therefore, the bicentennial of the expedition is being celebrated from 2003 until 2006. Students and teachers celebrating the bicentennial and Jefferson's Louisiana Purchase in 1803 can use social studies classes to help them connect with their community and to reach a…

Morris, Ronald V.; McNeely, Jean

2005-01-01

129

Lewis and Clark--Indiana Connections.  

ERIC Educational Resources Information Center

|The state of Indiana has an important, recognized connection to the Lewis and Clark Expedition. That connection is reinforced with a National Signature Event in Clarksville (Indiana) during October 2003. Until the expedition party left its winter camp in May 1804, it remained in Indiana Territory, governed from Vincennes (Indiana) by William…

Bennett, Pamela J., Ed.

2003-01-01

130

Host Lewis phenotype-dependent Helicobacter pylori Lewis antigen expression in rhesus monkeys  

PubMed Central

Both human and H. pylori populations are polymorphic for the expression of Lewis antigens. Using an experimental H. pylori challenge of rhesus monkeys of differing Lewis phenotypes, we aimed to determine whether H. pylori populations adapt their Lewis phenotypes to those of their hosts. After inoculation of four monkeys with a mixture of seven strains identified by RAPD-polymerase chain reaction, H. pylori Lewis expression was followed in 86 isolates obtained over 40 wk. Host Lewisa/b secretion status was characterized by immunological assays. Fingerprints of the predominating strain (J166) were identical in all four animals after 40 wk, but its Lewis phenotype had substantial variability in individual hosts. At 40 wk, J166 populations from two Lewisa?b+ animals predominantly expressed Lewisy. In contrast, J166 populations had switched to a Lewisx dominant phenotype in the two Lewisa+b? animals; a frame shift in futC, regulating conversion of Lewisx to Lewisy, accounted for the phenotypic switch. The results indicate that individual cells in H. pylori populations can change Lewis phenotypes during long-term colonization of natural hosts to resemble those of their hosts, providing evidence for host selection for bacterial phenotypes.

Wirth, Hans-Peter; Yang, Manqiao; Sanabria-Valentin, Edgardo; Berg, Douglas E.; Dubois, Andre; Blaser, Martin J.

2008-01-01

131

Investigating the Lewis acidity of aluminium fluoride surfaces  

NASA Astrophysics Data System (ADS)

The current study employs state of the art hybrid-exchange density functional theory (DFT) to investigate the Lewis acidic sites on the ?-AlF3 (100) surface. It is shown that the strong Lewis base, NH3, binds to the surface with a binding energy of up to 1.9 eV. This demonstrates that the material is strongly Lewis acidic. We also consider the binding of the weak Lewis base CO to the surface. We calculate the shift in its stretch frequency compared to the gas phase molecule. Shifts are compared to experimental data and are shown to be typical of strong Lewis acidity.

Bailey, C. L.; Mukhopadhyay, S.; Wander, A.; Harrison, N. M.

2008-03-01

132

Antimicrobial Potential and Chemical Characterization of Serbian Liverwort (Porella arboris-vitae): SEM and TEM Observations.  

PubMed

The chemical composition of Porella arboris-vitae extracts was determined by solid phase microextraction, gas chromatography-mass spectrometry (SPME GC-MS), and 66 constituents were identified. The dominant compounds in methanol extract of P. arboris-vitae were ?-caryophyllene (14.7%), ?-gurjunene (10.9%), ?-selinene (10.8%), ?-elemene (5.6%), ?-muurolene (4.6%), and allo-aromadendrene (4.3%) and in ethanol extract, ?-caryophyllene (11.8%), ?-selinene (9.6%), ?-gurjunene (9.4%), isopentyl alcohol (8.8%), 2-hexanol (3.7%), ?-elemene (3.7%), allo-aromadendrene (3.7%), and ?-muurolene (3.3%) were the major components. In ethyl acetate extract of P. arboris-vitae, undecane (11.3%), ?-caryophyllene (8.4%), dodecane (6.4%), ?-gurjunene (6%), 2-methyldecane (5.1%), hemimellitene (4.9%), and D-limonene (3.9%) were major components. The antimicrobial activity of different P. arboris-vitae extracts was evaluated against selected food spoilage microorganisms using microbroth dilution method. The Minimal Inhibitory Concentration (MIC) varied from 0.5 to 1.5?mg/mL and 1.25 to 2?mg/mL for yeast and bacterial strains, respectively. Significant morphological and ultrastructural alterations due to the effect of methanolic and ethanolic P. arboris-vitae extracts on S. Enteritidis have also been observed by scanning electron microscope and transmission electron microscope, respectively. The results provide the evidence of antimicrobial potential of P. arboris-vitae extracts and suggest its potential as natural antimicrobial agents for food preservation. PMID:23365607

Kumar Tyagi, Amit; Bukvicki, Danka; Gottardi, Davide; Veljic, Milan; Guerzoni, Maria Elisabetta; Malik, Anushree; Marin, Petar D

2013-01-09

133

Antimicrobial Potential and Chemical Characterization of Serbian Liverwort (Porella arboris-vitae): SEM and TEM Observations  

PubMed Central

The chemical composition of Porella arboris-vitae extracts was determined by solid phase microextraction, gas chromatography-mass spectrometry (SPME GC-MS), and 66 constituents were identified. The dominant compounds in methanol extract of P. arboris-vitae were ?-caryophyllene (14.7%), ?-gurjunene (10.9%), ?-selinene (10.8%), ?-elemene (5.6%), ?-muurolene (4.6%), and allo-aromadendrene (4.3%) and in ethanol extract, ?-caryophyllene (11.8%), ?-selinene (9.6%), ?-gurjunene (9.4%), isopentyl alcohol (8.8%), 2-hexanol (3.7%), ?-elemene (3.7%), allo-aromadendrene (3.7%), and ?-muurolene (3.3%) were the major components. In ethyl acetate extract of P. arboris-vitae, undecane (11.3%), ?-caryophyllene (8.4%), dodecane (6.4%), ?-gurjunene (6%), 2-methyldecane (5.1%), hemimellitene (4.9%), and D-limonene (3.9%) were major components. The antimicrobial activity of different P. arboris-vitae extracts was evaluated against selected food spoilage microorganisms using microbroth dilution method. The Minimal Inhibitory Concentration (MIC) varied from 0.5 to 1.5?mg/mL and 1.25 to 2?mg/mL for yeast and bacterial strains, respectively. Significant morphological and ultrastructural alterations due to the effect of methanolic and ethanolic P. arboris-vitae extracts on S. Enteritidis have also been observed by scanning electron microscope and transmission electron microscope, respectively. The results provide the evidence of antimicrobial potential of P. arboris-vitae extracts and suggest its potential as natural antimicrobial agents for food preservation.

Kumar Tyagi, Amit; Bukvicki, Danka; Gottardi, Davide; Veljic, Milan; Guerzoni, Maria Elisabetta; Malik, Anushree; Marin, Petar D.

2013-01-01

134

Calcium-based Lewis acid catalysts.  

PubMed

Recently, Lewis acidic calcium salts bearing weakly coordinating anions such as Ca(NTf?)?, Ca(OTf)?, CaF? and Ca[OCH(CF?)?]? have been discovered as catalysts for the transformation of alcohols, olefins and carbonyl compounds. High stability towards air and moisture, selectivity and high reactivity under mild reaction conditions render these catalysts a sustainable and mild alternative to transition metals, rare-earth metals or strong Brønsted acids. PMID:23712417

Begouin, Jeanne-Marie; Niggemann, Meike

2013-05-24

135

A Biographical Sketch of Lewis Dexter  

PubMed Central

Dr. Lewis Dexter was an outstanding cardiovascular physiologist and clinician, a respected teacher and scientist, and, most importantly, a fine human being. During his life, he brought the cardiac catheter from the laboratory to the patient and trained several generations of cardiologists. Dexter's laboratory was the first to elucidate the pathophysiologic alterations present in many forms of congenital heart disease, including atrial septal defects, patent ductus arteriosus, tetralogy of Fallot, ventricular septal defects, and pulmonic stenosis. Subsequent work in Dexter's laboratory led to the 1st measurements of pulmonary capillary wedge pressure and to the precise calculation of stenotic valve areas from hemodynamic parameters measured during cardiac catheterization. During a teaching exercise, Dexter demonstrated that exercise with a cardiac catheter in the heart was safe and produced clinically important data, by having a cardiac catheter inserted in himself. Over the years, many significant pathophysiologic studies that explored pulmonary embolism, valvular heart disease, right and left ventricular function, and pulmonary hypertension were published from Dexter's laboratory. But Lewis Dexter was more than a brilliant researcher. “Lew” was very close to his fellows and students, whom he considered extensions of his family. Dexter was a remarkable teacher, a compassionate physician, and a scrupulously honest investigator. Dr. Lewis Dexter had a major impact on modern medicine and was one of the great cardiologists of the 20th century.

Mukhopadhyay, Madhuri

2001-01-01

136

A biographical sketch of Lewis Dexter.  

PubMed

Dr. Lewis Dexter was an outstanding cardiovascular physiologist and clinician, a respected teacher and scientist, and, most importantly, a fine human being. During his life, he brought the cardiac catheter from the laboratory to the patient and trained several generations of cardiologists. Dexter's laboratory was the first to elucidate the pathophysiologic alterations present in many forms of congenital heart disease, including atrial septal defects, patent ductus arteriosus, tetralogy of Fallot, ventricular septal defects, and pulmonic stenosis. Subsequent work in Dexter's laboratory led to the 1st measurements of pulmonary capillary wedge pressure and to the precise calculation of stenotic valve areas from hemodynamic parameters measured during cardiac catheterization. During a teaching exercise, Dexter demonstrated that exercise with a cardiac catheter in the heart was safe and produced clinically important data, by having a cardiac catheter inserted in himself. Over the years, many significant pathophysiologic studies that explored pulmonary embolism, valvular heart disease, right and left ventricular function, and pulmonary hypertension were published from Dexter's laboratory. But Lewis Dexter was more than a brilliant researcher "Lew" was very close to his fellows and students, whom he considered extensions of his family Dexter was a remarkable teacher, a compassionate physician, and a scrupulously honest investigator. Dr Lewis Dexter had a major impact on modern medicine and was one of the great cardiologists of the 20th century. PMID:11453126

Mukhopadhyay, M

2001-01-01

137

Lewis Information Network (LINK): Background and overview  

NASA Astrophysics Data System (ADS)

The NASA Lewis Research Center supports many research facilities with many isolated buildings, including wind tunnels, test cells, and research laboratories. These facilities are all located on a 350 acre campus adjacent to the Cleveland Hopkins Airport. The function of NASA-Lewis is to do basic and applied research in all areas of aeronautics, fluid mechanics, materials and structures, space propulsion, and energy systems. These functions require a great variety of remote high speed, high volume data communications for computing and interactive graphic capabilities. In addition, new requirements for local distribution of intercenter video teleconferencing and data communications via satellite have developed. To address these and future communications requirements for the next 15 yrs, a project team was organized to design and implement a new high speed communication system that would handle both data and video information in a common lab-wide Local Area Network. The project team selected cable television broadband coaxial cable technology as the communications medium and first installation of in-ground cable began in the summer of 1980. The Lewis Information Network (LINK) became operational in August 1982 and has become the backbone of all data communications and video.

Schulte, Roger R.

1987-11-01

138

Towards a Construction of Inclusive Collision Cross-Sections in the Massless Nelson Model  

NASA Astrophysics Data System (ADS)

The conventional approach to the infrared problem in perturbative quantum electrodynamics relies on the concept of inclusive collision cross-sections. A non-perturbative variant of this notion was introduced in algebraic quantum field theory. Relying on these insights, we take first steps towards a non-perturbative construction of inclusive collision cross-sections in the massless Nelson model. We show that our proposal is consistent with the standard scattering theory in the absence of the infrared problem and discuss its status in the infrared-singular case.

Dybalski, Wojciech

2012-09-01

139

Extension of Nelson's stochastic quantization to finite temperature using thermo field dynamics  

NASA Astrophysics Data System (ADS)

We present an extension of Nelson's stochastic quantum mechanics to finite temperature. Utilizing the formulation of Thermo Field Dynamics (TFD), we can show that Ito's stochastic equations for tilde and non-tilde particle positions reproduce the TFD-type Schrödinger equation which is equivalent to the Liouville-von Neumann equation. In our formalism, the drift terms in the Ito's stochastic equation have the temperature dependence and the thermal fluctuation is induced through the correlation of the non-tilde and tilde particles. We show that our formalism satisfies the position-momentum uncertainty relation at finite temperature.

Kobayashi, K.; Yamanaka, Y.

2011-08-01

140

Using the Curriculum Vita to Study the Career Paths of Scientists and Engineers: An Exploratory Assessment  

Microsoft Academic Search

In this paper we assess the utility of the curriculum vita (CV) as a data source for examining the career paths of scientists and engineers. CVs were obtained in response to an email message sent to researchers working in the areas of biotechnology and microelectronics. In addition, a number of CVs were obtained \\

James S. Dietz; Ivan Chompalov; Barry Bozeman

2000-01-01

141

THE CURRICULUM VITAE AND THE MOTIVATIONAL LETTER: A RHETORICAL AND CULTURAL ANALYSIS  

Microsoft Academic Search

The paper reports on a study intended to tap into t he characteristics of the Hungarian culture in an attempt to develop intercultural competence in the Hungarian English as a foreign language (EFL) conte xt. It focuses on exploring two related genres, the curric ulum vitae (CV) and the motivational letter (ML) in terms of their rhetorical structure with the

Ildikó Furka

142

Thuja occidentalis (Arbor vitae): A Review of its Pharmaceutical, Pharmacological and Clinical Properties  

Microsoft Academic Search

Arbor vitae (Thuja occidentalis L.) is a native European tree widely used in homeopathy and evidence-based phytotherapy. Many reviews and monographs have been published on the herbal substance's descrip- tion, mode of action and clinical use. However, no comprehensive evidence-based review is available. Therefore, our aim was to search MEDLINE databases and survey manufacturers for further details or unpublished data.

Belal Naser; Cornelia Bodinet; Martin Tegtmeier; Ulrike Lindequist

2005-01-01

143

Salute mentale ed alterazione delle abitudini di vita dei lavoratori giovani  

Microsoft Academic Search

RIASSUNTO. Le alterazioni delle abitudini di vita costituiscono fattori di rischio per la salute. Esse determinano da un lato un alto tasso di patologie e mortalità, e dall'altro la riduzione del rendimento lavorativo e l'aumento del rischio di infortuni, con ripercussioni rilevanti sia in termini di salute dei lavoratori che economici. Lo scopo di questo studio è di analizzare le

G. Tomei; C. Cangemi; R. Giubilati; M. Fioravanti

2007-01-01

144

Franciscan history, apocalypticism, and reform: The Arbor vitae crucifixae Jesu of Ubertino da Casale  

Microsoft Academic Search

This dissertation seeks to explore the presence and significance of reform and renewal ideology, as well the apocalyptic content, found in the Spiritual Franciscan Ubertino da Casale's Arbor vitae crucifixae Jesu (1305). To accomplish these goals, this dissertation examines the historical and ideological background of the Franciscan Order and Ubertino's place in it. It also discusses the structure of the

Gregory Scott Beirich

1999-01-01

145

The Vita Activa as Compass: Navigating Uncertainty in Teaching with Hannah Arendt  

ERIC Educational Resources Information Center

|This dissertation is an exploration of stories of uncertainty in the lives of elementary teachers and the value that the ideas of Hannah Arendt lend to the discussion around uncertainty. In "The Human Condition" (1958) Hannah Arendt theorizes the life of action, the "vita activa". Arendtian action is inherently uncertain because to be "capable of…

Rogers, Carrie Ann Barnes

2010-01-01

146

[Lewy bodies, a misleading marker for Parkinson's disease?].  

PubMed

The Lewy body, an eosinophilic inclusion around 10 microns in diameter, is localised in the neuronal perikaryon. Its dense core is surrounded by a clear halo, which is lacking in the so-called "cortical Lewy bodies". Numerous proteins have been identified in Lewy bodies, among which the three neurofilament isoforms, ubiquitin and proteasome subunits. More recently, alpha-synuclein--a pre-synaptic protein--has been found to be the essential constituent of the Lewy body. Alpha-synuclein antibody has greatly increased the sensitivity of the neuropathological examination: it has emphasized the frequency of "Lewy neurites" (accumulation of alpha--synuclein in neuronal processes) and has shown the importance of extra-nigral pathology. Lewy bodies and neurites are indeed to be found in many areas of the central and peripheral nervous system: stellate ganglia, cardiac and enteric plexus, pigmented nuclei of the brainstem, basal nucleus of Meynert, amygdala, limbic nuclei of the thalamus, parahippocampal and cingulate gyri, insula and isocortex. Lewy body diseases include at least three clinical syndromes: 1) idiopathic Parkinson disease in which the brainstem bears the brunt of the pathology 2) Parkinson disease dementia in which Lewy lesions are found in the brainstem and are also abundant in the isocortex. A large number of senile plaques is frequently associated. 3) In dementia with Lewy bodies, the same lesions are observed but the cognitive deficit occurs first or shortly (less than one year) after the motor symptoms. PMID:14556441

Duyckaerts, Charles; Hauw, Jean-Jacques

2003-01-01

147

Development and validation of detailed controls models of the Nelson River Bipole 1 HVDC system  

SciTech Connect

With the Nelson River Bipole 1 mercury arc valve group replacement project and planning for the expansion of the Nelson River HVDC system with a third bipole underway, it was decided to pursue a program to develop and validate detailed models of the existing HVDC transmission facilities and their associated ac systems for use in system studies. The first phase of the program concentrated on the development of detailed controls models associated with the Bipole 1 transmission facility. Based on previous experience at Manitoba Hydro with the Electromagnetic Transient DC simulation program (EMTDC), it was decided that model development and validation would use this program. This paper presents the reasons behind the development of detailed models, the methods used in developing models related to Bipole 1, results of validation tests, difficulties encountered during the process, and the overall benefits resulting from the project. An example of applying the models to investigate a low frequency oscillation which has occurred on the dc system in the past is also presented.

Kuffel, P.; Kent, K.L.; Mazur, G.B.; Weekes, M.A. (Manitoba Hydro, Winnipeg (Canada))

1993-01-01

148

Global Warming and Lewis and Clark College  

NSDL National Science Digital Library

This website describes the actions undertaken by students at Lewis and Clark College to comply with the greenhouse gas emissions targets called for in the Kyoto Protocol. The effort was student-driven, and will cost approximately $10 per student. This achievement is the result of a three-year student campaign involving greenhouse gas inventories, student polls demonstrating overwhelming support, emissions reductions on campus, and the use of student fees to purchase &quot;offsets&quot; from the Climate Trust, a Portland nonprofit. The site provides links to articles by the students who spearheaded the movement, as well as more in-depth coverage of their efforts.

College, Lewis A.

149

78 FR 48315 - Drawbridge Operation Regulation; Lewis and Clark River, Astoria, OR  

Federal Register 2010, 2011, 2012, 2013

...Drawbridge Operation Regulation; Lewis and Clark River, Astoria, OR AGENCY: Coast Guard, DHS...operating schedule that governs the Lewis and Clark Bridge which crosses the Lewis and Clark River, mile 1.0, at Astoria, OR. The...

2013-08-08

150

Familial Occurrence of Dementia With Lewy Bodies  

PubMed Central

Objective. The authors investigated the validity of the designation “familial dementia with Lewy bodies (DLB)” by evaluating the clinical, neuropathological, and genetic characteristics of previously reported families exhibiting both familial parkinsonism and dementia. Methods. Several families, including multiple individuals with parkinsonism as well as prominent dementia, were identified through a literature search. Selected families had at least one member with dementia with autopsy evidence of neocortical and/or limbic Lewy-body (LB) pathology. Clinical and neuropathological evidence from reports of families with prominent dementia as well as parkinsonism was reviewed to further define familial DLB. Results. All selected families had at least one affected individual with dementia and autopsy-proven DLB. Therefore, these families might be considered examples of familial DLB. Individuals in the first six families typically presented with parkinsonian features, whereas cognitive decline did not appear until years later. In contrast, in the other six families, affected individuals typically presented with cognitive decline, and parkinsonism developed later. Conclusions. Families exist in which one or more persons meet both clinical and neuropathological criteria for DLB. They differ as to whether the signs of parkinsonism precede or follow signs of dementia. It remains to be determined whether this clinical distinction is biologically important. Susceptibility to developing LB pathology may be determined by the interaction between genetic predisposition and environmental risk factors.

Tsuang, Debby W.; DiGiacomo, Lillian; Bird, Thomas D.

2006-01-01

151

Determination of critical habitat for the endangered Nelson's bighorn sheep in southern California  

USGS Publications Warehouse

The United States Fish and Wildlife Service's (USFWS) designation of critical habitat for the endangered Nelson's bighorn sheep (Ovis canadensis nelsoni) in the Peninsular Ranges of southern California has been controversial because of an absence of a quantitative, repeatable scientific approach to the designation of critical habitat. We used 12,411 locations of Nelson's bighorn sheep collected from 1984-1998 to evaluate habitat use within 398 km2 of the USFWS-designated critical habitat in the northern Santa Rosa Mountains, Riverside County, California. We developed a multiple logistic regression model to evaluate and predict the probability of bighorn use versus non-use of native landscapes. Habitat predictor variables included elevation, slope, ruggedness, slope aspect, proximity to water, and distance from minimum expanses of escape habitat. We used Earth Resources Data Analysis System Geographic Information System (ERDAS-GIS) software to view, retrieve, and format predictor values for input to the Statistical Analysis Systems (SAS) software. To adequately account for habitat landscape diversity, we carried out an unsupervised classification at the outset of data inquiry using a maximum-likelihood clustering scheme implemented in ERDAS. We used the strata resulting from the unsupervised classification in a stratified random sampling scheme to minimize data loads required for model development. Based on 5 predictor variables, the habitat model correctly classified >96% of observed bighorn sheep locations. Proximity to perennial water was the best predictor variable. Ninety-seven percent of the observations were within 3 km of perennial water. Exercising the model over the northern Santa Rosa Mountain study area provided probabilities of bighorn use at a 30 x 30-m2 pixel level. Within the 398 km 2 of USFWS-designated critical habitat, only 34% had a graded probability of bighorn use to non-use ranging from ???1:1 to 6,044:1. The remaining 66% of the study area had odds of having bighorn use <1:1 or it was more likely not to be used by bighorn sheep. The USFWS designation of critical habitat included areas (45 km2) of importance (2.5 to ???40 observations per km2 per year) to Nelson's bighorn sheep and large landscapes (353 km2) that do not appear to be used (<1 observation per km2 per year).

Turner, J. C.; Douglas, C. L.; Hallum, C. R.; Krausman, P. R.; Ramey, R. R.

2004-01-01

152

Summary of Research Report Lewis Incubator for Technology.  

National Technical Information Service (NTIS)

This report summarizes the work done to establish and operate the Lewis Incubator for Technology (LIFT) for the period July 1996 through September 2000. The Lewis Incubator helps the startup and growth of technology-based businesses with the potential to ...

W. P. Zeman

2000-01-01

153

Difficulty Processing Temporary Syntactic Ambiguities in Lewy Body Spectrum Disorder  

ERIC Educational Resources Information Center

|While grammatical aspects of language are preserved, executive deficits are prominent in Lewy body spectrum disorder (LBSD), including Parkinson's disease (PD), Parkinson's dementia (PDD) and dementia with Lewy bodies (DLB). We examined executive control during sentence processing in LBSD by assessing temporary structural ambiguities. Using an…

Grossman, Murray; Gross, Rachel G.; Moore, Peachie; Dreyfuss, Michael; McMillan, Corey T.; Cook, Philip A.; Ash, Sherry; Siderowf, Andrew

2012-01-01

154

Modern Exploration of the Lewis and Clark Expedition.  

National Technical Information Service (NTIS)

The Lewis and Clark Geosystem is an online collection of private, state, local, and Federal data resources associated with the geography of the Lewis and Clark Expedition. Data were compiled from key partners including NASA s Stennis Space Center, the U.S...

2006-01-01

155

GROUSE OF THE LEWIS AND CLARK EXPEDITION, 1803 TO 1806  

Microsoft Academic Search

Members of the Lewis and Clark expedition produced written descriptions of many species of wildlife, including 6 species of grouse. We reviewed the accounts of 83 grouse observations, plus summary descriptions and indirect references to grouse by Meriwether Lewis, William Clark, and 3 of their sergeants. We then assigned them to species based on described characteristics, known distributions, habitat, behavior,

FRED CZ WICKEL

156

The Organization of Narrative Discourse in Lewy Body Spectrum Disorder  

ERIC Educational Resources Information Center

|Narrative discourse is an essential component of day-to-day communication, but little is known about narrative in Lewy body spectrum disorder (LBSD), including Parkinson's disease (PD), Parkinson's disease with dementia (PDD), and dementia with Lewy bodies (DLB). We performed a detailed analysis of a semi-structured speech sample in 32…

Ash, Sharon; McMillan, Corey; Gross, Rachel G.; Cook, Philip; Morgan, Brianna; Boller, Ashley; Dreyfuss, Michael; Siderowf, Andrew; Grossman, Murray

2011-01-01

157

Impairments of Speech Fluency in Lewy Body Spectrum Disorder  

ERIC Educational Resources Information Center

Few studies have examined connected speech in demented and non-demented patients with Parkinson's disease (PD). We assessed the speech production of 35 patients with Lewy body spectrum disorder (LBSD), including non-demented PD patients, patients with PD dementia (PDD), and patients with dementia with Lewy bodies (DLB), in a semi-structured…

Ash, Sharon; McMillan, Corey; Gross, Rachel G.; Cook, Philip; Gunawardena, Delani; Morgan, Brianna; Boller, Ashley; Siderowf, Andrew; Grossman, Murray

2012-01-01

158

Thoughts on Teaching: John L. Lewis, Jesus, and President Bush.  

ERIC Educational Resources Information Center

Bobby Ann Starnes, the author of this article, grew up with portraits of two important people displayed prominently in her home, Jesus, and John L. Lewis. Lewis, a giant among American leaders in the first half of the twentieth century, sent hundreds of organizers to help create some of the nation's leading labor unions, including the United…

Starnes, Bobby Ann

2004-01-01

159

Impairments of Speech Fluency in Lewy Body Spectrum Disorder  

ERIC Educational Resources Information Center

|Few studies have examined connected speech in demented and non-demented patients with Parkinson's disease (PD). We assessed the speech production of 35 patients with Lewy body spectrum disorder (LBSD), including non-demented PD patients, patients with PD dementia (PDD), and patients with dementia with Lewy bodies (DLB), in a semi-structured…

Ash, Sharon; McMillan, Corey; Gross, Rachel G.; Cook, Philip; Gunawardena, Delani; Morgan, Brianna; Boller, Ashley; Siderowf, Andrew; Grossman, Murray

2012-01-01

160

Mo?bearing granodiorite porphyry plutons of the Early Cretaceous Separation Point Suite, west Nelson, New Zealand  

Microsoft Academic Search

In west Nelson a 130 km long belt containing granodiorite stocks with associated subeconomic stockwork Mo mineralisation is correlated with the I?type Separation Point Suite and Western Fiordland Orthogneiss, both of Early Cretaceous age. Trace element characteristics of relatively unaltered samples of these Mo?granite stocks, and the Separation Point Batholith, indicate an arc setting for both groups of rocks, which

A. J. Tulloch; S. D. C. Rabone

1993-01-01

161

Site distribution in the Fresno and Nelson Reservoir Areas, North Central Montana: Report of a Class III Cultural Resource Inventory.  

National Technical Information Service (NTIS)

An archeological and historic sites inventory around Fresno and Nelson Reservoirs in north central Montana was conducted. A total of nearly 400 features in 132 sites were recorded. Sites show a non-random distribution in relation to the areas's ecozones, ...

K. Deaver J. Morter

1981-01-01

162

First New Zealand record of probable dinosaur footprints from the Late Cretaceous North Cape Formation, northwest Nelson  

Microsoft Academic Search

Structures that are interpreted as dinosaur footprints are recorded from six localities within the Late Cretaceous (Maastrictian) aged North Cape Formation of northwest Nelson. These are the first dinosaur footprints to be recognised from New Zealand and the first occurrence of dinosaurs from the South Island, and add considerably to our knowledge of New Zealand dinosaurs, which currently is based

Greg H. Browne

2009-01-01

163

Nelson Mandela and F. W. de Klerk: A Comparative Rhetorical Analysis of their Visions of a New South Africa1  

Microsoft Academic Search

This study examined the rhetoric of two South African leaders, F.W de Klerk and Nelson Mandela, from 1990 to 1994, to determine their respective rhetorical visions of a new South Africa and the rhetorical strategies used to gain identification with their audiences.

Mary A. Brockett

164

'We Shall Crush Apartheid': Nelson Mandela, Steve Biko and the Rhetoric of the South African Anti-Apartheid Jeremiad  

Microsoft Academic Search

This essay recognizes the social protest rhetoric of former President Nelson Mandela and Black Consciousness Movement founder Steve Biko as jeremiads that called for social change in the midst of the apartheid despotic structure. Although they employed varying methods while delivering their jeremiads, they sought to fulfill their missions as representatives of justice and social equality. The uncovering of an

Willie J. Harrell

165

The "Naked Truth" Isn't Very Revealing: A Response to Wade Nelson on School Reform in Minnesota.  

ERIC Educational Resources Information Center

A participant in Minnesota's standards-based reform initiative claims Wade Nelson, in his May 1998 "Kappan" article, is misinformed about teachers' exclusion from this movement. The standards constitute a minimal competence level in reading, math, and writing, were developed cooperatively, and have raised teacher expectations of students.…

Pitton, Debra Eckerman

1999-01-01

166

The "Naked Truth" Isn't Very Revealing: A Response to Wade Nelson on School Reform in Minnesota.  

ERIC Educational Resources Information Center

|A participant in Minnesota's standards-based reform initiative claims Wade Nelson, in his May 1998 "Kappan" article, is misinformed about teachers' exclusion from this movement. The standards constitute a minimal competence level in reading, math, and writing, were developed cooperatively, and have raised teacher expectations of students.…

Pitton, Debra Eckerman

1999-01-01

167

Comments on Mika's critique of Hartnett, Nelson, and Rinn's article, “gifted or ADHD? The possibilities of misdiagnosis”  

Microsoft Academic Search

The Hartnett, Nelson, and Rinn 2004 study indicates that diagnostic confusion between ADD\\/ADHD and giftedness exists, and that research on medication practices is warranted. Mika disagrees, saying that there is no empirical evidence of misdiagnosis of gifted children as having ADD\\/ADHD. We disagree with Mika's logic, and describe evidence that suggests that such misdiagnosis does occur, with possible concurrent risks.

Jean Goerss; Edward R. Amend; James T. Webb; Nadia Webb; Paul Beljan

2006-01-01

168

Application of an improved Nelson-Nguyen analysis to eccentric, arbitrary profile liquid annular seals  

NASA Astrophysics Data System (ADS)

An improved dynamic analysis for liquid annular seals with arbitrary profile based on a method, first proposed by Nelson and Nguyen, is presented. An improved first order solution that incorporates a continuous interpolation of perturbed quantities in the circumferential direction, is presented. The original method uses an approximation scheme for circumferential gradients, based on Fast Fourier Transforms (FFT). A simpler scheme based on cubic splines is found to be computationally more efficient with better convergence at higher eccentricities. A new approach of computing dynamic coefficients based on external specified load is introduced. This improved analysis is extended to account for arbitrarily varying seal profile in both axial and circumferential directions. An example case of an elliptical seal with varying degrees of axial curvature is analyzed. A case study based on actual operating clearances of an interstage seal of the Space Shuttle Main Engine High Pressure Oxygen Turbopump is presented.

Padavala, Satyasrinivas; Palazzolo, Alan B.; Vallely, Pat; Ryan, Steve

1994-01-01

169

Observation of "Nelson's Nose" in an Ultrapure YBa_2Cu_3O7 Crystal  

NASA Astrophysics Data System (ADS)

Solid-liquid transition is associated with broken symmetries, and as such its phase boundary cannot have end points on the phase diagram. An outstanding question in the high-Tc vortex physics is the low-field behavior of the vortex-lattice melting line on the H-T phase diagram. We report a reentrant behavior of the melting line at low fields by using the peak effect as a signature of vortex-lattice melting in an ultrapure untwinned YBCO crystal in which a giant peak effect and a dc magnetization jump were observed previously. We suggest that this reentrant peak effect is a consequence of the reentrant melting line predicted by Nelson et al.

Ren, Cong; Henle, Mark; Ling, X. S.; Liang, Ruixing; Bonn, D. A.; Hardy, W. N.

2000-03-01

170

Intermediate depth earthquakes beneath Nelson, New Zealand, and the southwestern termination of the subducted Pacific plate  

NASA Astrophysics Data System (ADS)

There has been debate on how convergence of mantle lithosphere is accommodated during continental collision in the central South Island of New Zealand-whether by intracontinental subduction or continuous deformation of mantle lithosphere. Intermediate depth earthquakes are sparse beneath the central South Island, and abundant seismicity 130-230 km deep within the Hikurangi subduction zone to the northeast ends abruptly beneath the Nelson region of the northern South Island. This termination of seismicity has previously been interpreted as marking the southwestern edge of the subducted slab. Here we investigate the stress and strain regime at this termination of activity, and find that it is very similar to that within the subducted plate both updip and along strike towards the northeast. Our results are consistent with subduction continuing further southwest, albeit largely aseismically, as suggested by shallow earthquakes in the northeastern South Island.

Reyners, Martin; Robertson, Elizabeth de J.

2004-02-01

171

General knowledge norms: Updated and expanded from the Nelson and Narens (1980) norms.  

PubMed

The Nelson and Narens (Journal of Verbal Learning and Verbal Behavior 19:338-368, 1980) general knowledge norms have been valuable to researchers in many fields. However, much has changed over the 32 years since the 1980 norms. For example, in 1980, most people knew the answer to the question "What is the name of the Lone Ranger's Indian sidekick?" (answer: Tonto), whereas in 2012, few people know this answer. Thus, we updated the 1980 norms and expanded them by providing new measures. In particular, we report two new metacognitive measures (confidence judgments and peer judgments) and provide a detailed report of commission errors. Each of these measures will be valuable to researchers, and together they are likely to facilitate future research in a number of fields, such as research investigating memory illusions, metamemory processes, and error correction. The presence of substantial generational shifts from 1980 to 2012 necessitates the use of updated norms. PMID:23344739

Tauber, Sarah K; Dunlosky, John; Rawson, Katherine A; Rhodes, Matthew G; Sitzman, Danielle M

2013-01-24

172

TO CURE E TO CARE IN SITUAZIONI DI FINE VITA: LA PROPORZIONALITÀ E LE CURE PALLIATIVE  

Microsoft Academic Search

SINTESI Per affrontare i temi bioetici inerenti alla fi ne della vita occorre mettere a fuoco la questione della proporzionalità dei trattamenti. Spesso la dimenticanza del limite intrinseco all'arte medica può sfociare in un duplice e contraddittorio atteggiamento: l'accanimento terapeutico da una lato, l'abbandono terapeutico dall'altro. L'incapacità di riconoscere nel concreto la fi nitezza porta infatti a non accettare la

Elena Colombetti

2009-01-01

173

CommOnCV: modelling the competencies underlying a curriculum vitae  

Microsoft Academic Search

This paper presents the project CommOnCV, which aims at dealing with the problematics of e---recruitment by considering a new approach based on competency management. The idea consists of allowing a job seeker (respectively a recruiter to identify and formally represent the competencies underlying its Curriculum Vitae (respectively its job offer). These competencies, which allow to make explicit knowledge, skills, abilities,

Mounira Harzallah; Michel Leclère; Francky Trichet

2002-01-01

174

Juxtarenal aortic aneurysms: preliminary experience with fenestrated E-vita abdominal stent-graft.  

PubMed

Endovascular aneurysm repair (EVAR) offers a minimally invasive treatment to patients with improved short-term and similar mid-term results compared to conventional, open repair. Approximately 20% of patients have an aneurysm neck morphology inadequate for a standard stent-graft and requires an endograft to cross vital aortic side branches to achieve a seal. This work describes the promising single center preliminary results in the management of juxtarenal aortic aneurysm using E-vita stent-graft. PMID:24013538

Ricci, C; Ceccherini, C; Cini, M; Vigni, F; Leonini, S; Puliti, A; Benvenuti, A; Tucci, E; Tommasino, G; Muzzi, L; Neri, E

2013-08-01

175

Lewis morris rutherfurd 1816-1892.  

PubMed

Lewis M. Rutherfurd (1816-1892) was a wealthy amateur practitioner of science, making notable contributions to the optics of astronomy and spectroscopy. He graduated from Williams College at the age of 18 and soon began a career in law. Not long thereafter he was fortunate enough to acquire sufficient wealth through marriage to permit him to pursue scientific activity, for which he had gained interest. He soon became interested in photographing the heavens to obtain quantitative data regarding star motions. A few years later he developed a spectrometer with which he obtained some of the best attainable stellar spectra of the time. Rutherfurd is not widely known because he did not fully report his work; but through correspondence and instrument development he had a profound influence on his contemporaries. He was made a trustee of Columbia College in 1858, and in 1881 he helped to found a department of Geodesy and Practical Astronomy there. PMID:20165259

Devons, S

1976-07-01

176

Developing a mobile curriculum vitae using weblog: a cross-disciplinary survey on university students’ perception based on Technology Acceptance Model  

Microsoft Academic Search

A traditional Curriculum Vitae (CV) fails to highlight the candidates’ strength, skills and achievement effectively. Thus, graduates are unable to sell and present themselves in an interactive way in order to impress the employer. In the digital age, mobile phones and Wi-Fi are ubiquitous; thus, an online CV namely “Mobile Curriculum Vitae” (m-CV) is created and proposed to be the

Boon Yih Mah; Wan Syakira Meor Hissan; Pei Eng Chng

2011-01-01

177

The Impact of Gender on the Review of the Curricula Vitae of Job Applicants and Tenure Candidates: A National Empirical Study  

Microsoft Academic Search

The purpose of this study was to determine someof the factors that influence outside reviewers andsearch committee members when they are reviewingcurricula vitae, particularly with respect to the gender of the name on the vitae. The participants inthis study were 238 male and female academicpsychologists who listed a university address in the1997 Directory of the American PsychologicalAssociation. They were each

Rhea E. Steinpreis; Katie A. Anders; Dawn Ritzke

1999-01-01

178

Lewis Acid-Base, Molecular Modeling, and Isotopic Labeling in a Sophomore Inorganic Chemistry Laboratory  

ERIC Educational Resources Information Center

|An experiment to prepare a deuterium labeled adduct of a Lewis acid and Lewis base, to use computational methods allowing students to visualize the LUMO of Lewis acids, the HOMO of Lewis bases and the molecular orbitals of the adduct that is formed is developed. This allows students to see the interplay between calculated and experimental…

Nataro, Chip; Ferguson, Michelle A.; Bocage, Katherine M.; Hess, Brian J.; Ross, Vincent J.; Swarr, Daniel T.

2004-01-01

179

Relationship of Blood Group Determinants on Helicobacter pylori Lipopolysaccharide with Host Lewis Phenotype and Inflammatory Response  

Microsoft Academic Search

Received 14 May 1999\\/Returned for modification 28 July 1999\\/Accepted 8 November 1999 As Lewis a (Lea) and Lewis b (Leb) blood group antigens are isoforms of Lewis x (Lex) and Lewis y (Ley) and are expressed in the gastric mucosa, we evaluated whether the patterns of expression of Lex and Ley on Helico- bacter pylori lipopolysaccharides reflected those of host

MICHAEL A. HENEGHAN; CIARAN F. MCCARTHY; ANTHONY P. MORAN

2000-01-01

180

Dementia with Lewy bodies showing advanced Lewy pathology but minimal Alzheimer pathology--Lewy pathology causes neuronal loss inducing progressive dementia.  

PubMed

The present study concerns an autopsied case of dementia with Lewy bodies (DLB) showing advanced Lewy pathology but minimal Alzheimer pathology. The patient was a 50-year-old Japanese male without inheritance. His initial symptoms at the age of 43 suggested the diagnosis ofjuvenile idiopathic Parkinson's disease (PD), but were followed by memory disturbance 1 year later. He showed parkinsonism, dementia, personality change, fluctuating cognition and visual hallucinations 3 years later. Neuroradiological examination revealed moderate brain atrophy, predominantly in the frontal and temporal lobes. Neuropathological examination demonstrated a widespread occurrence of Lewy bodies (LB) with LB-related neurites not only in the brainstem but also in the cerebrum. The present case showed Lewy pathology which corresponded to stage IV by our staging and was parallel to neuronal loss. There was marked neuronal loss with many LB-related neurites in the CA2 of the hippocampus. Neurofibrillary tangles (NFT) were almost restricted to the entorhinal cortex, while senile plaques were absent. Consequently, the present case was pathologically diagnosed as having DLB of the neocortical type, pure form. In the present study, we suggest that Lewy pathology in the cerebral cortex could be responsible for progressive dementia. PMID:12489676

Uchikado, H; Iseki, E; Tsuchiya, K; Togo, T; Katsuse, O; Uéda, K; Kato, M; Kosaka, K

181

Seals Related Research at NASA. Lewis Research Center.  

National Technical Information Service (NTIS)

Some current efforts in seal research at the Lewis Research Center include self-sealing linear segmented ceramic configurations, the T700 brush seal engine test, flow and duration characteristics of brush seals and other configurations, cryogenic hydrogen...

R. C. Hendricks

1991-01-01

182

Telecommuting (Work-at-Home) at NASA Lewis Research Center.  

National Technical Information Service (NTIS)

This report presents a study in evaluating the viability of providing a work-at-home (telecommuting) program for Lewis Research Center's corporate employees using Integrated Services Digital Network (ISDN). Case studies have been presented for a range of ...

S. M. Srinidhi

1994-01-01

183

Lewis & Clark 200th Anniversary: 1804-2004  

Microsoft Academic Search

This is the online component of the exhibit displayed in the Georgia State University Library, July - August 2004, to commemorate the 200th anniversary of the beginning of the Lewis and Clark Expedition in May, 1804.

Skye Hardesty; Tammy Sugarman

2004-01-01

184

Research and Technology Highlights of the Lewis Research Center.  

National Technical Information Service (NTIS)

Highlights of research accomplishments of the Lewis Research Center for fiscal year 1984 are presented. The report is divided into four major sections covering aeronautics, space communications, space technology, and materials and structures. Six articles...

1984-01-01

185

Computational Fluid Dynamics at the Lewis Research Center: An Overview.  

National Technical Information Service (NTIS)

Lewis is a multidisciplinary Center with strong research and development programs in aeronautical and space propulsion, power, space communications, space experiments and materials. Computational fluid dynamics (CFD) is playing an important and growing ro...

R. M. Stubbs

1989-01-01

186

Lewis Y Antigen as a Target for Breast Cancer Therapy.  

National Technical Information Service (NTIS)

Lewis antigens are blood group carbohydrate antigens implicated as potential target antigens in breast cancer. Studies supported by this grant are intended to develop reagents that better target these antigens which might prove to be valuable as immunothe...

T. Keiber-Emmons

1995-01-01

187

The National Council of the Lewis and Clark Bicentennial  

NSDL National Science Digital Library

In 1803, President Thomas Jefferson sent Captains Meriwether Lewis and William Clark on an expedition westward in the hope of mapping a transcontinental water route to the Pacific Ocean. The National Council of the Lewis and Clark Bicentennial is a coalition of agencies created to mark the 200th anniversary of Lewis and Clark's three-year journey. At the group's Web site, visitors will find the calendar for fifteen signature events that trace the expedition's route, beginning January 18th, 2003, at Monticello, Jefferson's home in Virginia, and ending September 23, 2006, in St. Louis, Missouri. Stops in between include Fort Atkinson State Historical Park, Nebraska, in July and August of 2004, where there will be an outdoor reenactment of the meeting between the Lewis and Clark's expedition and the Otoe and Missouria Tribes, and Fort Clatsop National Memorial in Astoria, Oregon, in November 2005, where, in 1805, Clark wrote in his journal that the Pacific Ocean was in view.

2002-01-01

188

LSENS, The NASA Lewis Kinetics and Sensitivity Analysis Code.  

National Technical Information Service (NTIS)

A general chemical kinetics and sensitivity analysis code for complex, homogeneous, gas-phase reactions is described. The main features of the code, LSENS (the NASA Lewis kinetics and sensitivity analysis code), are its flexibility, efficiency and conveni...

K. Radhakrishnan

2000-01-01

189

Alcohol consumption, Lewis phenotypes, and risk of ischemic heart disease  

Microsoft Academic Search

The authors have previously found an increased risk of ischemic heart disease (IHD) in men with the Lewis phenotype Le(a[minus]b[minus]) and suggested that the Lewis blood group has a close genetic relation with insulin resistance. The authors have investigated whether any conventional risk factors explain the increased risk in Le(a[minus]b[minus]) men. 3,383 men aged 53-75 years were examined in 1985-86,

H. O. Hein; P. Suadicani; F. Gyntelberg; H. Sorenson

1993-01-01

190

Diffuse Lewy Body Disease: Clinical, Pathological, and Neuropsychological Review  

Microsoft Academic Search

The pathophysiological etiologies and clinical presentations of neurodegenerative dementias have been found to be complex and heterogeneous. Recently, Lewy body inclusions have been identified as an etiological factor in 20–34% of autopsied dementia cases. The term diffuse Lewy body disease (DLBD) is generally accepted as the diagnostic term representative of this currently under-reported and under-recognized disease. This article reviews the

Cheryl A. Luis; Wiley Mittenberg; Carlton S. Gass; Ranjan Duara

1999-01-01

191

Reduced striatal tyrosine hydroxylase in incidental Lewy body disease  

Microsoft Academic Search

Incidental Lewy body disease (ILBD) is the term used when Lewy bodies are found in the nervous system of subjects without\\u000a clinically documented parkinsonism or dementia. The prevalence of ILBD in the elderly population has been estimated at between\\u000a 3.8 and 30%, depending on subject age and anatomical site of sampling. It has been speculated that ILBD represents the preclinical

Thomas Gerald Beach; Charles H. Adler; Lucia I. Sue; Jeffrey B. Peirce; Jyothi Bachalakuri; Jessica E. Dalsing-Hernandez; Lih Fen Lue; John N. Caviness; Donald J. Connor; Marwan N. Sabbagh; Douglas G. Walker

2008-01-01

192

Birds and Mammals Observed by Lewis & Clark in North Dakota  

NSDL National Science Digital Library

The Northern Prairie Wildlife Research Center (NPWRC) provides this interesting resource detailing the birds and mammals observed by Lewis and Clark in North Dakota. Originally printed in 1927 in North Dakota Historical Quarterly, this information has been resummarized by Russell Reid and Clell G. Gannon, and includes an annotated list of "all birds and mammals observed by Lewis and Clark during their trek through what is now North Dakota." This resource may be downloaded as a .zip file.

193

Lewis Research Center (LeRC) Space Directorate  

NSDL National Science Digital Library

The Space Directorate is the Lewis Research Center's primary interface with NASA "to explore, advocate and develop new opportunities in microgravity science, space technology, launch vehicle services and space applications." The Directorate is divided into four offices: Space Communications, Launch Services and Transportation Project, Microgravity Science, and Power and Propulsion. Each office has a brief mission statement and links to ongoing projects posted here. The site also links directly to the Lewis Research Center.

1998-01-01

194

NASA Lewis Stirling engine computer code evaluation  

NASA Astrophysics Data System (ADS)

In support of the U.S. Department of Energy's Stirling Engine Highway Vehicle Systems program, the NASA Lewis Stirling engine performance code was evaluated by comparing code predictions without engine-specific calibration factors to GPU-3, P-40, and RE-1000 Stirling engine test data. The error in predicting power output was -11 percent for the P-40 and 12 percent for the Re-1000 at design conditions and 16 percent for the GPU-3 at near-design conditions (2000 rpm engine speed versus 3000 rpm at design). The efficiency and heat input predictions showed better agreement with engine test data than did the power predictions. Concerning all data points, the error in predicting the GPU-3 brake power was significantly larger than for the other engines and was mainly a result of inaccuracy in predicting the pressure phase angle. Analysis into this pressure phase angle prediction error suggested that improvements to the cylinder hysteresis loss model could have a significant effect on overall Stirling engine performance predictions.

Sullivan, Timothy J.

1989-01-01

195

NASA Lewis Stirling engine computer code evaluation  

SciTech Connect

In support of the US Department of Energy's Stirling Engine Highway Vehicle Systems program, the NASA Lewis Stirling engine performance code was evaluated by comparing code predictions without engine-specific calibration factors to GPU-3, P-40, and RE-1000 Stirling engine test data. The error in predicting power output was /minus/11 percent for the P-40 and 12 percent for the RE-1000 at design conditions and 16 percent for the GPU-3 at near-design conditions (2000 rpm engine speed versus 3000 rpm at design). The efficiency and heat input predictions showed better agreement with engine test data than did the power predictions. Concerning all data points, the error in predicting the GPU-3 brake power was significantly larger than for the other engines and was mainly a result of inaccuracy in predicting the pressure phase angle. Analysis into this pressure phase angle prediction error suggested that improvement to the cylinder hysteresis loss model could have a significant effect on overall Stirling engine performance predictions. 13 refs., 26 figs., 3 tabs.

Sullivan, T.J.

1989-01-01

196

Harmonically confined Tonks-Girardeau gas: A simulation study based on Nelson's stochastic mechanics  

NASA Astrophysics Data System (ADS)

We present a simulation study of the properties of the Tonks-Girardeau gas, a system of N hard-core bosons confined in a one-dimensional harmonic trap. For this system the ground-state wave function is exactly known based on a Bose-Fermi mapping theorem. We employ Nelsons' interpretation of quantum mechanics in which this N-body wave function gives rise to a set of stochastic differential equations for the positions of the N particles, which can be simulated by standard methods. In particular, real space densities and momentum distributions can simply be determined by time averages along particle trajectories. Employing this approach we are able to significantly extend the range of particle numbers N treated numerically compared to earlier approaches, while reproducing all exactly known results for this model. We also show that for the bosons in a harmonic trap, contrary to what has been assumed so far, the momentum distribution reflects the system size scaling of the occupation numbers of the natural orbitals; that is, it can be used to decide on the presence of a Bose-Einstein condensate.

Paul, W.

2012-07-01

197

An observational study of ice effects on Nelson River estuarine variability, Hudson Bay, Canada  

NASA Astrophysics Data System (ADS)

Many estuaries in high latitude regions are subjected to seasonally ice-covered conditions. However, ice effects on estuarine variability have received limited scientific attention and remain poorly understood. In this paper, an 11-month mooring record is used to examine seasonal variation of estuarine hydrodynamics in the Nelson River estuary (NRE), Hudson Bay (HB), in northern Canada. We show that ice cover strongly affects tidal amplitudes, velocities and phases in the NRE. In the mid-winter, the M2 tidal amplitude and consequently the tidal range are significantly reduced due to under-ice friction in HB, while conversely the M2 tidal velocity is amplified due to reduction of cross-section of the channel by formation of fast ice. A stronger surface seaward residual flow observed in the winter indicates that the formation of fast ice could also enhance the residual circulation. Suspended sediment concentration in the river mouth is reduced, also possibly due to the formation of fast ice that protects shallow nearshore shoals from erosion. This study demonstrates the importance of ice effects on estuarine variability and the complexity of processes in a seasonally ice-covered estuary.

Wang, Ruixue; McCullough, Greg K.; Gunn, Geoffrey G.; Hochheim, Klaus P.; Dorostkar, Abbas; Sydor, Kevin; Barber, David G.

2012-09-01

198

Treatment of Nelson's syndrome by pituitary implantation of yttrium-90 or gold-198.  

PubMed Central

Eight patients with Nelson's syndrome were treated with a pituitary implant of yttrium-90 or gold-198 four to 16 years after adrenal surgery. All had considerable pigmentation. One already had cranial nerve abnormalities and visual field defects and had had both a craniotomy and deep x-ray treatment. Radiographs showed that the pituitary fossa was abnormal in seven patients. A biopsy performed in six cases showed mucoid (or basophil) adenoma in all. In the four specimens examined ACTH was identified by electron microscopy or immunofluorescence, or both. Patients were followed up after pituitary implantation for three months to 12 years. All showed decreased pigmentation, and six became normal. Four patients regained normal ACTH levels and the other two studied had decreased levels. In no case did new cranial nerve disease or further sellar expansion develop since operation, and two patients showed remodelling of the sella. Complications were temporary leakage of cerebrospinal fluid and diabetes insipidus in one patient and gonadotrophin deficiency in another. Images FIG 1 FIG 2

Cassar, J; Doyle, F H; Lewis, P D; Mashiter, K; Noorden, S; Joplin, G F

1976-01-01

199

Amyloid imaging of Lewy body-associated disorders  

PubMed Central

Background Clinicopathologic studies of Parkinson disease dementia (PDD) and dementia with Lewy bodies (DLB) commonly reveal abnormal ?-amyloid deposition in addition to diffuse Lewy bodies (?-synuclein aggregates), but the relationship among these neuropathologic features and the development of dementia in these disorders remains uncertain. Objective To determine whether amyloid-?deposition detected by PET imaging with Pittsburgh Compound B (PIB) distinguishes clinical subtypes of Lewy body-associated disorders. Methods Nine healthy controls (HC), eight PD with no cognitive impairment (PD-noCI), nine PD with mild cognitive impairment (PD-MCI), six dementia with Lewy bodies (DLB) and fifteen PD with dementia (PDD) patients underwent [11C]-PIB PET imaging, clinical examination, and cognitive testing. The binding potential (BP) of PIB for predefined regions and the mean cortical BP (MCBP) were calculated for each participant. Annual longitudinal follow-up and postmortem examinations were performed on a subset of participants. Results Regional PIB BPs and the proportion of individuals with abnormally elevated MCBP were not significantly different across participant groups. Elevated PIB binding was associated with worse global cognitive impairment in participants with Lewy body disorders but was not associated with any other clinical or neuropsychological features, including earlier onset or faster rate of progression of cognitive impairment. Conclusions These results suggest that the presence of fibrillar amyloid-?does not distinguish between clinical subtypes of Lewy body-associated disorders, although larger numbers are needed to more definitively rule out this association. Amyloid-?may modify the severity of global cognitive impairment in individuals with Lewy body-associated dementia.

Foster, E.R.; Campbell, M.C.; Burack, M.A.; Hartlein, J.; Flores, H.P.; Cairns, N.J.; Hershey, T.; Perlmutter, J.S.

2010-01-01

200

The relative playfulness of juvenile Lewis and Fischer-344 rats.  

PubMed

The relative playfulness of inbred Lewis and Fischer-344 rats was characterized. Fischer rats were consistently less playful than Lewis rats, with rats of this strain less likely to initiate playful interactions with either responsive or unresponsive partners and also less likely to respond playfully when playful solicitations were directed to them. While less playful, Fischer rats were more socially inquisitive than Lewis rats when tested with an unresponsive partner, suggesting that Fischer rats are less likely to escalate a social encounter into a playful one. Strain differences in playful responsiveness were present with or without prior social isolation, suggesting that this aspect of play represents a relatively stable trait difference. Unlike play responsiveness, strain differences in play solicitation were only apparent after a period of social isolation. Low levels of play were still present in Fischer rats that had been reared by Lewis dams, suggesting a genetic source for the altered play in rats of this strain. Further studies of play behavior in Lewis and Fischer rats could illuminate relevant neural involvement in rough-and-tumble play and also help understand the genetic bases for this complex social behavior. PMID:14637239

Siviy, Stephen M; Love, Nicole J; DeCicco, Brian M; Giordano, Sara B; Seifert, Tara L

2003-11-01

201

Dementia with Lewy bodies. Review of diagnosis and pharmacologic management.  

PubMed Central

OBJECTIVE: To review clinical features of dementia with Lewy bodies (DLB) and to guide family physicians in pharmacologic management, including medications to avoid. QUALITY OF EVIDENCE A MEDLINE: search of literature from 1995 to 2002 used the MeSH terms dementia with Lewy bodies/diagnosis, dementia with Lewy bodies/therapy, and antipsychotics/dementia with Lewy bodies. Level II and III evidence was available for diagnosis and treatment of DLB. One randomized controlled trial of rivastigmine was reviewed and appraised. MAIN MESSAGE: Dementia with Lewy bodies is common. Diagnosis can be made by family physicians using clinical criteria including presence of dementia with marked fluctuation in performance, hallucinations, and the onset of parkinsonism. Cholinesterase inhibitors should be considered for neuropsychiatric symptoms. Levodopa-carbidopa combinations should be considered for treatment of parkinsonism. Neuroleptics should be used with caution because of the risk of serious sensitivity reactions. If they are needed, atypical agents could be safer. CONCLUSION: Recognition and diagnosis of DLB is important to optimize pharmacologic management and to minimize risk of adverse reactions to neuroleptics.

Frank, Christopher

2003-01-01

202

DAVID CERVI E SALOMONE DE VITA: GIOIELLIERI EBREI AL SERVIZIO DEI DUCHI GONZAGA. NOTE D'ARCHIVIO  

Microsoft Academic Search

The article explores on the basis of archival documents the lives of David Cervi and Salomone de Vita Levi. Jews residing in Mantova, they were the jewellers and trustees in the dealings of the dukes of Gonzaga, William, Vincent the First, and Ferdinand. In the company of their sons they travelled unceasingly between Milan, Venice, Rome, Turin and Prague from

Paola Venturelli

2002-01-01

203

The professoriate in the field of educational administration : Insights from an analysis of journal authors' curricula vitae  

Microsoft Academic Search

Purpose – Based on a qualitative content analysis of 57 curricula vitae of authors who published their work in the major journals of the educational administration (EA) field, this paper seeks to display the career of EA authors and to suggest some epistemological implications for the field. Design\\/methodology\\/approach – The analysis is based on both quantitative and qualitative modes of

Izhar Oplatka

2010-01-01

204

Habitat Selection and Reproductive Success of Lewis's Woodpecker (Melanerpes lewis) at Its Northern Limit  

PubMed Central

Lewis's Woodpecker (Melanerpes lewis) has experienced population declines in both Canada and the United States and in 2010 was assigned a national listing of threatened in Canada. We conducted a two-year study (2004–2005) of this species at its northern range limit, the South Okanagan Valley in British Columbia, Canada. Our main objective was to determine whether the habitat features that influenced nest-site selection also predicted nest success, or whether other factors (e.g. cavity dimensions, clutch initiation date or time of season) were more important. Nest tree decay class, density of suitable cavities and total basal area of large trees were the best predictors of nest-site selection, but these factors were unrelated to nesting success. Estimates of demographic parameters (mean ± SE) included daily nest survival rate (0.988±0.003, years combined), nest success (0.52±0.08), clutch size (5.00±0.14 eggs), female fledglings per successful nest (1.31±0.11), and annual productivity (0.68±0.12 female fledglings per nest per year). Although higher nest survival was associated with both early and late initiated clutches, early-initiated clutches allowed birds to gain the highest annual productivity as early clutches were larger. Nests in deep cavities with small entrances experienced lower predation risk especially during the peak period of nest predation. We concluded that nest-site selection can be predicted by a number of easily measured habitat variables, whereas nest success depended on complicated ecological interactions among nest predators, breeding behaviors, and cavity features. Thus, habitat-based conservation strategies should also consider ecological factors that may not be well predicted by habitat.

Zhu, Xiang; Srivastava, Diane S.; Martin, Kathy

2012-01-01

205

The Lewis and Clark Expedition and the USGS  

NSDL National Science Digital Library

The Lewis and Clark Expedition was the first of many government surveys of natural resources in the American West, a task taken over in later years by the United States Geological Survey (USGS). The discussion includes the early surveys of the West (by King, Powell, Hayden, and Wheeler) and their relation to the USGS mission. There is also a page devoted to scientific discoveries made by Lewis and Clark such as the channeled scablands carved by the draining of Lake Missoula, and the volcanoes of the Cascades Range. Other materials include information on the USGS 125th anniversary, exhibits on the Lewis and Clark Expedition, map products devoted to the expedition, information on the role of Native Americans in the expedition, and a section of educational materials for educators and students.

206

Lewis acidity of organofluorophosphonium salts: hydrodefluorination by a saturated acceptor.  

PubMed

Prototypical Lewis acids, such as boranes, derive their reactivity from electronic unsaturation. Here, we report the Lewis acidity and catalytic application of electronically saturated phosphorus-centered electrophilic acceptors. Organofluorophosphonium salts of the formula [(C6F5)(3-x)Ph(x)PF][B(C6F5)4] (x = 0 or 1; Ph, phenyl) are shown to form adducts with neutral Lewis bases and to react rapidly with fluoroalkanes to produce difluorophosphoranes. In the presence of hydrosilane, the cation [(C6F5)3PF](+) is shown to catalyze the hydrodefluorination of fluoroalkanes, affording alkanes and fluorosilane. The mechanism demonstrates the impressive fluoride ion affinity of this highly electron-deficient phosphonium center. PMID:24052304

Caputo, Christopher B; Hounjet, Lindsay J; Dobrovetsky, Roman; Stephan, Douglas W

2013-09-20

207

Mondelez Global LLC Conducts Nationwide Voluntary Recall of belVita Breakfast Biscuit Apple Cinnamon and Chocolate Varieties in the U.S. and Puerto Rico  

NASA Website

Mondelez Global LLC announced today a nationwide voluntary recall in the United States, including Puerto Rico, of the belVita Breakfast Biscuit product, Apple Cinnamon and Chocolate varieties, following notification from a third-party supplier, due to ...

208

Crystalline, lewis base-free, cationic phosphoranimines (iminophosphonium salts).  

PubMed

Cationic phosphoranimines have been postulated as intermediates in phosphazene polymerization chemistry. However, the high electrophilicity of the phosphorus center has so far prevented their characterization. Here, we report the synthesis of two Lewis base-free iminophosphonium salts, obtained by reaction of a stable phosphinonitrene with methyl trifluoromethanesulfonate and trifluoromethanesulfonic acid. These cationic species were characterized by NMR spectroscopy and single-crystal X-ray diffraction analysis. Using 4-(dimethylamino)pyridine, a corresponding Lewis-base adduct has also been isolated. PMID:24007472

Dielmann, Fabian; Moore, Curtis E; Rheingold, Arnold L; Bertrand, Guy

2013-09-12

209

The Lewis factor and its influence on the performance prediction of wet-cooling towers  

Microsoft Academic Search

The effect of the Lewis factor, or Lewis relation, on the performance prediction of natural draft and mechanical draft wet-cooling towers is investigated. The Lewis factor relates the relative rates of heat and mass transfer in wet-cooling towers. The history and development of the Lewis factor and its application in wet-cooling tower heat and mass transfer analyses are discussed. The

Johannes C. Kloppers; Detlev G. Kröger

2005-01-01

210

Contrasting Styles of Monazite Growth in the Nelson Contact Aureole, British Columbia.  

NASA Astrophysics Data System (ADS)

The Jurassic Nelson Batholith in southern British Columbia has undergone post-intrusion tilting, such that the surrounding contact aureole reveals a series of contrasting pressure-dependent prograde mineral assemblage sequences in pelitic rocks of similar bulk composition. Three east-west transects across the aureole within 10 km of each other show garnet-staurolite bearing rocks in the north (highest pressure), andalusite + biotite ± garnet-bearing rocks along the middle transect, and garnet-free cordierite-bearing assemblages in the south (lowest pressure). The low-grade pelitic protolith in all three transects is virtually identical with respect to both major and accessory mineral assemblages, containing biotite + muscovite + quartz + albitic plagioclase + graphite with abundant, sub- to euhedral apatite, euhedral allanite, and no monazite. The transition from an allanite-dominant to monazite-bearing assemblage is seen texturally in both of the southerly transects, where monazite can be shown to directly replace allanite downgrade of either cordierite or andalusite development. In the most southerly transect, rocks in the cordierite + biotite zone contain distinct `clusters' of monazite, most likely as pseudomorphs after allanite. These monazites show no chemical zonation, and little change in morphology or distribution from low to high grade. In the middle transect, rocks in the andalusite zone show two distinct forms of monazite, depending on the presence or absence of garnet. Samples without garnet contain monazite distributed in clusters, as described above. In contrast, garnet-bearing rocks contain monazite as lone grains in the matrix, often with a high Th core. With increasing grade, these monazites become coarser, with a more rounded, regular shape, and commonly display a Th+Y-rich rim. In the highest pressure, garnet + staurolite-bearing samples, the garnet-in isograd abruptly marks the last appearance of allanite and the first occurrence of monazite. Monazite resembles that in the garnet-bearing samples of the middle transect, with lone grains in the matrix, high Th cores and some evidence for Th+Y zonation at higher grades. Despite the coexistence of garnet and staurolite in the highest pressure transect, there is no evidence to suggest garnet breakdown during staurolite formation, suggesting that monazite growth is not controlled directly by garnet growth or consumption. In all transects, monazite appears to grow at the expense of allanite. In garnet-free rocks the allanite to monazite transition is gradual, and involves pseudomorphous replacement of allanite by monazite clusters. In garnet-bearing rocks the transition is more abrupt, and probably due to the growth of garnet, leading to the destruction of allanite and formation of individual, isolated monazite grains in the matrix.

Tomkins, H. S.; Pattison, D. R.

2004-05-01

211

Non-humidified proton conduction between a Lewis acid-base pair.  

PubMed

Proton conduction in zirconium sulphate (ZrSO4) composed of a Lewis acid-base pair was studied. ZrSO4 exhibits non-humidified proton conductivity, comparable to other proton conductors under similar conditions. Ab initio calculation shows that a proton transfers in ZrSO4 from a Lewis acid to a Lewis base without a proton carrier. PMID:23842882

Ogawa, Takaya; Ohashi, Hidenori; Tamaki, Takanori; Yamaguchi, Takeo

2013-07-11

212

33 CFR 117.899 - Youngs Bay and Lewis and Clark River.  

Code of Federal Regulations, 2010 CFR

...2009-07-01 false Youngs Bay and Lewis and Clark River. 117.899 Section 117.899... § 117.899 Youngs Bay and Lewis and Clark River. (a) The draw of the US101...given to the drawtender at the Lewis and Clark River Bridge by marine radio,...

2009-07-01

213

33 CFR 117.899 - Youngs Bay and Lewis and Clark River.  

Code of Federal Regulations, 2010 CFR

...2010-07-01 false Youngs Bay and Lewis and Clark River. 117.899 Section 117.899... § 117.899 Youngs Bay and Lewis and Clark River. (a) The draw of the US101...given to the drawtender at the Lewis and Clark River Bridge by marine radio,...

2010-07-01

214

Phenotypic diversity in Lewis expression of Helicobacter pylori isolates from the same host  

Microsoft Academic Search

Populations of Helicobacter pylori cells show a stable expression of Lewis surface antigens, although phase variation may occur among individual organisms grown in vitro. We searched for variation in Lewis phenotypes among H. pylori cells of minimally in vitro-passaged isolates. Lewis expression in 180 clonal H. pylori populations from the primary culture of 20 gastric biopsy samples from 12 patients,

Hans-Peter Wirth; Manqiao Yang; Richard M Peek; Johanna Höök-Nikanne; Michael Fried; Martin J Blaser

1999-01-01

215

Book Review of Venereal Disease and the Lewis and Clark Expedition by Thomas P. Lowry  

Microsoft Academic Search

Although Lewis and Clark literature has proliferated in the last decade, few works have added scholarly discourse to this field of study. The highly focused Venereal Disease and the Lewis and Clark Expedition, however, will likely stand out on the Lewis and Clark bookshelf as an important contribution.

Ronald V. Loge

2006-01-01

216

A critical evaluation of current staging of ?-synuclein pathology in Lewy body disorders  

Microsoft Academic Search

The two most frequent synucleinopathies, Parkinson disease (PD) or brainstem predominant type of Lewy body disease, and dementia with Lewy bodies (DLB), are neurodegenerative multisystem disorders with widespread occurrence of ?-synuclein containing deposits in the central, peripheral, and autonomic systems. For both Lewy body-related disorders staging\\/classification systems based on semiquantitative assessment of the distribution and progression pattern of ?-synuclein pathology

Kurt A. Jellinger

2009-01-01

217

Consumer Reaction to the Fort Lewis CAFe System.  

National Technical Information Service (NTIS)

2471 interviews were conducted at Ft. Lewis, Washington, to determine consumer reaction to the model food service system (CAFe). The results indicate that the food prepared within the central kitchens of CAFe, and even the food prepared on-site in CAFe fa...

H. L. Meiselman L. G. Branch

1972-01-01

218

Hypersonic engine seal development at NASA Lewis Research Center  

Microsoft Academic Search

NASA Lewis Research Center is developing advanced seal concepts and sealing technology for advanced combined cycle ramjet\\/scramjet engines being designed for the National Aerospace Plane (NASP). Technologies are being developed for both the dynamic seals that seal the sliding interfaces between articulating engine panels and sidewalls, and for the static seals that seal the heat exchanger to back-up structure interfaces.

Bruce M. Steinetz

1994-01-01

219

Lewis Terman: Genetic Study of Genius--Elementary School Students  

ERIC Educational Resources Information Center

|Although the field of gifted education generally recognizes the foundational work of Lewis Terman, rarely does one stop to examine the details of his longitudinal study and their connection to present-day gifted education. This article reexamines the beginnings of Terman's longitudinal study with a focus on elementary-school-aged children.…

Jolly, Jennifer L.

2008-01-01

220

174. Photocopy of Photograph (original in Roger Lewis' private collection). ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

174. Photocopy of Photograph (original in Roger Lewis' private collection). Photographer and date unknown. SNAKE RIVER BELOW MILNER DAM SITE, TWIN FALLS COUNTY, MILNER, IDAHO; RAPIDS JUST BELOW MILNER TOWNSITE. - Milner Dam & Main Canal: Twin Falls Canal Company, On Snake River, 11 miles West of city of Burley, Idaho, Twin Falls, Twin Falls County, ID

221

Fiscal decentralization in Indonesia: A comment on smoke and lewis  

Microsoft Academic Search

In World Development Smoke and Lewis (1996) describe a local government capability rating effort in Indonesia, and conclude that this approach to decentralization has great potential. Their analysis is bound to a limited set of central level actors, and thus reflects only part of the decentralization debate in Indonesia. Consequently the authors miss the roots of this purportedly “new” approach

Gabriele Ferrazzi

1998-01-01

222

Crystallization of the Lewis-Wahnström ortho-terphenyl model  

Microsoft Academic Search

Crystallization is observed during microsecond long molecular dynamics simulations of bent trimers, a molecular model proposed by Lewis and Wahnström for ortho-terphenyl. In the crystal, the three spheres that make up the rigid molecule sit near sites of a body centered cubic lattice. The trimer bond angle is almost optimal for this structure. The crystal exhibits orientational disorder with the

Ulf R. Pedersen; Toby S. Hudson; Peter Harrowell

2011-01-01

223

Lewis Latimer: African American Inventor, Poet and Activist.  

ERIC Educational Resources Information Center

Details a lesson plan that examines the life and career of Lewis Latimer. Latimer, the self-taught son of fugitive slaves, rose to a prominent position in Thomas Edison's Electric Company and pioneered many innovations in the early electric industry. Includes a biographical sketch of Latimer, photographs, and illustrations. (MJP)

Judd, Michael

1998-01-01

224

False Recognition in Lewy-Body Disease and Frontotemporal Dementia  

ERIC Educational Resources Information Center

|The primary goal of this study was to evaluate the false recognition phenomenon in persons with frontotemporal dementia (FTD) and those with Lewy-body disease (LBD). Patients with LBD (n=10) or FTD (n=15) and their corresponding controls (n=30) were subjected to the Deese-Roediger-McDermott (DRM) paradigm to induce false recognition. Patients…

de Boysson, C.; Belleville, S.; Phillips, N. A.; Johns, E. K.; Goupil, D.; Souchay, C.; Bouchard, R.; Chertkow, H.

2011-01-01

225

Mars Pathfinder Rover-Lewis Research Center Technology Experiments Program  

Microsoft Academic Search

An overview of NASA's Mars Pathfinder Program is given and the development and role of three technology experiments from NASA's Lewis Research Center and carried on the Mars Pathfinder rover is described. Two recent missions to Mars were developed and managed by the Jet Propulsion Laboratory, and launched late last year: Mars Global Surveyor in November 1996 and Mars Pathfinder

Steven M. Stevenson

1997-01-01

226

Lewis F. Richardson and the analysis of war  

NASA Astrophysics Data System (ADS)

We show that since about 1970 the strategic nuclear weaponry of the US and the USSR have been following the classic exponential growth pattern first discussed by Lewis Fry Richardson, the founder of mathematical analysis of war. We also present data suggesting a correlation between war deaths and two-generation, half century long waves (Konratieff cycles) in human systems.

Craig, Paul P.; Levine, Mark D.

1983-10-01

227

Neural correlates of psychotic symptoms in dementia with Lewy bodies.  

PubMed

The aim of this study was to investigate the association between psychotic symptoms in dementia with Lewy bodies and brain perfusion on single photon emission tomography. Based on factor analysis in 145 patients, psychotic symptoms were classified into five symptom domains (factor 1 to 4-related symptoms and delusions). The relationship between each symptom domain and brain perfusion was assessed in 100 patients with dementia with Lewy bodies, while accounting for the effects of age, sex, dementia severity, parkinsonism and dysphoria. Factor 1 symptoms (Capgras syndrome, phantom boarder, reduplication of person and place and misidentification of person) represented misidentifications, and were significantly related to hypoperfusion in the left hippocampus, insula, ventral striatum and bilateral inferior frontal gyri. Factor 3 symptoms (visual hallucination of person and feeling of presence) represented hallucinations of person and were related to hypoperfusion in the left ventral occipital gyrus and bilateral parietal areas. Delusions of theft and persecution were associated with relative hyperperfusion in the right rostral medial frontal cortex, left medial superior frontal gyrus and bilateral dorsolateral frontal cortices. This study revealed that different psychotic symptoms in dementia with Lewy bodies were associated with distinguishable cerebral networks. Visual hallucinations were related to dysfunction of the parietal and occipital association cortices, misidentifications were related to dysfunction of the limbic-paralimbic structures and delusions were related to dysfunction of the frontal cortices. Our findings provide important insights into the pathophysiological mechanisms underlying psychotic symptoms in dementia with Lewy bodies. PMID:19920063

Nagahama, Yasuhiro; Okina, Tomoko; Suzuki, Norio; Matsuda, Minoru

2009-11-17

228

Impact of Predatory Threat on Fear Extinction in Lewis Rats  

ERIC Educational Resources Information Center

Humans with post-traumatic stress disorder (PTSD) are deficient at extinguishing conditioned fear responses. A study of identical twins concluded that this extinction deficit does not predate trauma but develops as a result of trauma. The present study tested whether the Lewis rat model of PTSD reproduces these features of the human syndrome.…

Goswami, Sonal; Cascardi, Michele; Rodriguez-Sierra, Olga E.; Duvarci, Sevil; Pare, Denis

2010-01-01

229

Dementia with Lewy bodies in a Nigerian: a case report.  

PubMed

Dementia with Lewy bodies (DLB) is the second most common neuropathologically diagnosed cause of degenerating dementia after Alzheimer's disease. We report the first autopsy-confirmed case in sub-Saharan Africa in a Nigerian patient. The case presented highlights the varied clinical presentation of DLB, and is intended to raise awareness about another possible cause of dementia in Nigerian subjects. PMID:12243211

Ogunnyi, Adesola; Akang, Effiong E U; Gureje, Oye; Takao, Masaki; Piccardo, Pedro; Baiyewu, Olusegun; Hall, Kathleen S; Ghetti, Bernardino; Hendrie, Hugh C

2002-06-01

230

Telling Lewis Hine's Story: Russell Freedman's "Kids at Work."  

ERIC Educational Resources Information Center

|In "Kids at Work," Russell Freedman explores the world of child labor during the years 1908-1918 when Lewis Hine, "teacher-crusader," worked as an investigative photographer for the National Child Labor Committee (NCLC). Hine's writing and the photos he gathered from across the country revealed a "shocking reality that most Americans had never…

Zarnowski, Myra

231

Impact of Predatory Threat on Fear Extinction in Lewis Rats  

ERIC Educational Resources Information Center

|Humans with post-traumatic stress disorder (PTSD) are deficient at extinguishing conditioned fear responses. A study of identical twins concluded that this extinction deficit does not predate trauma but develops as a result of trauma. The present study tested whether the Lewis rat model of PTSD reproduces these features of the human syndrome.…

Goswami, Sonal; Cascardi, Michele; Rodriguez-Sierra, Olga E.; Duvarci, Sevil; Pare, Denis

2010-01-01

232

A Legacy of Dandelions: Carolyn Lewis Attneave (1990-1992).  

ERIC Educational Resources Information Center

Discusses the legacy of Carolyn Lewis Attneave who was, according to T. D. LaFromboise and J. E. Trimble (1966), "undoubtedly the most well-known psychologist of American Indian background." Reviews Attneave's work in organizations across the United States promoting the causes of American Indian families and community mental health and her skill…

Heckman-Stone, Carolyn

2000-01-01

233

Ethics and economics: Lewis Gray and the conservation question  

Microsoft Academic Search

In “The Economic Possibilities of Conservation” [1913], Lewis Gray reinterpreted from an economic point of view the idea of conservation which had popularized the American Conservation Movement. He linked intergenerational equity and non-renewable resource extraction rate. Gray’s article can be considered as an antecedent of two significant debates in modern natural resource economics. On the one hand, it is a

José Luis Ramos Gorostiza

2002-01-01

234

Lewis Base Mediated ?-Elimination and Lewis Acid Mediated Insertion Reactions of Disilazido Zirconium Compounds.  

PubMed

The reactivity of a series of disilazido zirconocene complexes is dominated by the migration of anionic groups (hydrogen, alkyl, halide, OTf) between the zirconium and silicon centers. The direction of these migrations is controlled by the addition of two-electron donors (Lewis bases) or two-electron acceptors (Lewis acids). The cationic nonclassical [Cp2ZrN(SiHMe2)2](+) ([2](+)) is prepared from Cp2Zr{N(SiHMe2)2}H (1) and B(C6F5)3 or [Ph3C][B(C6F5)4], while reactions of B(C6F5)3 and Cp2Zr{N(SiHMe2)2}R (R = Me (3), Et (5), n-C3H7 (7), CH?CHSiMe3 (9)) provide a mixture of [2](+) and [Cp2ZrN(SiHMe2)(SiRMe2)](+). The latter products are formed through B(C6F5)3 abstraction of a ?-H and R group migration from Zr to the ?-Si center. Related ?-hydrogen abstraction and X group migration reactions are observed for Cp2Zr{N(SiHMe2)2}X (X = OTf (11), Cl (13), OMe (15), O-i-C3H7 (16)). Alternatively, addition of DMAP (DMAP = 4-(dimethylamino)pyridine) to [2](+) results in coordination to a Si center and hydrogen migration to zirconium, giving the cationic complex [Cp2Zr{N(SiHMe2)(SiMe2DMAP)}H](+) ([19](+)). Related hydrogen migration occurs from [Cp2ZrN(SiHMe2)(SiMe2OCHMe2)](+) ([18](+)) to give [Cp2Zr{N(SiMe2DMAP)(SiMe2OCHMe2)}H](+) ([22](+)), whereas X group migration is observed upon addition of DMAP to [Cp2ZrN(SiHMe2)(SiMe2X)](+) (X = OTf ([12](+)), Cl ([14](+))) to give [Cp2Zr{N(SiHMe2)(SiMe2DMAP)}X](+) (X = OTf ([26](+)), Cl ([20](+))). The species involved in these transformations are described by resonance structures that suggest ?-elimination. Notably, such pathways are previously unknown in early metal amide chemistry. Finally, these migrations facilitate direct Si-H addition to carbonyls, which is proposed to occur through a pathway that previously had been reserved for later transition metal compounds. PMID:24067161

Yan, Kaking; Duchimaza Heredia, Juan J; Ellern, Arkady; Gordon, Mark S; Sadow, Aaron D

2013-09-25

235

Liquid-fuel burning with nonunitary Lewis number  

SciTech Connect

An analysis is presented for liquid-fuel vaporization and burning with nonunitary Lewis number (i.e., nonsimilar heat and mass diffusion) in a general geometrical situation, e.g., a dense spray. Variable transport properties are considered and only Stefan flow is allowed. The analysis builds on the approach of Imaoka and Sirignano for unitary Lewis number. Fickian diffusion with differing diffusivities for each species is considered. It is shown that the problem can conveniently be separated, using a mass-flux potential function, into a one-dimensional problem for the quasi-steady, gas-phase scalar properties and a three-dimensional problem for the mass-flux potential, which satisfies Laplace's equation. This allows some previous calculations of the potential function for unitary Lewis number to be used for the potential-function solution. The scalar properties are shown to be functions of the mass-flux potential only. It is demonstrated that a mass-flux-weighted sensible specific enthalpy is more natural and convenient than the traditional mass-weighted value. This modification results in a new definition of the Lewis number. A generalization of the classical Spalding heat transfer number is presented. The theory predicts scalar gas-phase profiles, flame position, and vaporization rates. Quantitative results are presented for special cases where the Lewis number is piecewise constant. The thin-flame temperature and the effective latent heat of vaporization can be determined as functions of the liquid-surface temperature via solution of nonlinear algebraic equations; these values do not depend on the specific configuration and therefore have some universality. (author)

Sirignano, William A. [Department of Mechanical and Aerospace Engineering, University of California, Irvine, CA 92697-3975 (United States)

2007-02-15

236

Diffuse Lewy body disease: correlative neuropathology using anti-ubiquitin immunocytochemistry.  

PubMed Central

Diffuse Lewy body disease is an important pathological substrate of the common syndrome of parkinsonian dementia. The new technique of anti-ubiquitin immunocytochemistry has been used in a correlative quantitative neuropathological study of fifteen cases of diffuse Lewy body disease, showing that the severity of dementia is related to cortical Lewy body density, whilst subcortical abnormalities make a much less significant contribution. Cortical senile plaques also appear to be part of the pathology of diffuse Lewy body disease and should not therefore be used as an isolated diagnostic criterion for Alzheimer's disease. Diagnostic criteria for diffuse Lewy body disease are discussed. Images

Lennox, G; Lowe, J; Landon, M; Byrne, E J; Mayer, R J; Godwin-Austen, R B

1989-01-01

237

Statement of Facts for 1975 City-Wide Mock Trial Competitions. Georgia Floyd, Individually and as Parent and Next Friend of Minor, Nelson Floyd v. Fix-It Home Remodeling, Inc. and Sam Baldwin.  

ERIC Educational Resources Information Center

|Prepared by the District of Columbia Street Law Project for its annual city-wide mock trial competition, this instructional handout provides material for a civil trial over a claim for damages. During an argument, a friend pushed Nelson Floyd against the railing of a porch. Falling onto the concrete below, Nelson was injured with a broken shin…

National Inst. for Citizen Education in the Law, Washington, DC.

238

Imaging and acetylcholinesterase inhibitor response in dementia with Lewy bodies  

PubMed Central

Acetylcholinesterase inhibitors are commonly used to treat patients with dementia with Lewy bodies. Hippocampal atrophy on magnetic resonance imaging and amyloid-? load on positron emission tomography are associated with the Alzheimer’s disease-related pathology in patients with dementia with Lewy bodies. To date, few studies have investigated imaging markers that predict treatment response in patients with dementia with Lewy bodies. Our objective was to determine whether imaging markers of Alzheimer’s disease-related pathology such as hippocampal volume, brain amyloid-? load on 11C Pittsburgh compound B positron emission tomography predict treatment response to acetylcholinesterase inhibitors in patients with dementia with Lewy bodies. We performed a retrospective analysis on consecutive treatment-naive patients with dementia with Lewy bodies (n?=?54) from the Mayo Clinic Alzheimer’s Disease Research Centre who subsequently received acetylcholinesterase inhibitors and underwent magnetic resonance imaging with hippocampal volumetry. Baseline and follow-up assessments were obtained with the Mattis Dementia Rating Scale. Subjects were divided into three groups (reliable improvement, stable or reliable decline) using Dementia Rating Scale reliable change indices determined previously. Associations between hippocampal volumes and treatment response were tested with analysis of covariance adjusting for baseline Dementia Rating Scale, age, gender, magnetic resonance field strength and Dementia Rating Scale interval. Seven subjects underwent 11C Pittsburgh compound B imaging within 12 weeks of magnetic resonance imaging. Global cortical 11C Pittsburgh compound B retention (scaled to cerebellar retention) was calculated in these patients. Using a conservative psychometric method of assessing treatment response, there were 12 patients with reliable decline, 29 stable cases and 13 patients with reliable improvement. The improvers had significantly larger hippocampi than those that declined (P?=?0.02) and the stable (P?=?0.04) group. An exploratory analysis demonstrated larger grey matter volumes in the temporal and parietal lobes in improvers compared with those who declined (P?Lewy bodies who do not have the imaging features of coexistent Alzheimer’s disease-related pathology are more likely to cognitively improve with acetylcholinesterase inhibitor treatment.

Graff-Radford, Jonathan; Boeve, Bradley F.; Pedraza, Otto; Ferman, Tanis J.; Przybelski, Scott; Lesnick, Timothy G.; Vemuri, Prashanthi; Senjem, Matthew L.; Smith, Glenn E.; Knopman, David S.; Lowe, Val; Jack, Clifford R.; Petersen, Ronald C.

2012-01-01

239

Performance Evaluation of a New Blood Glucose Monitor That Requires No Coding: The OneTouch® Vita™ System  

Microsoft Academic Search

Background: Improvements to blood glucose monitoring systems aim to simplify the testing process, reduce or eliminate errors, and provide additional information for patients with diabetes. New systems must continue to demonstrate high-quality analytical performance. The new OneTouch® Vita™ System (LifeScan, Inc., Milpitas, CA) offers a no-code testing process and proven technology found in the OneTouch® Ultra® System. Comparative studies were

Joanna K. Young; John M. Ellison; Robert Marshall

240

Parkin Localizes to the Lewy Bodies of Parkinson Disease and Dementia with Lewy Bodies  

PubMed Central

Mutations in ?-synuclein (?S) and parkin cause heritable forms of Parkinson disease (PD). We hypothesized that neuronal parkin, a known E3 ubiquitin ligase, facilitates the formation of Lewy bodies (LBs), a pathological hallmark of PD. Here, we report that affinity-purified parkin antibodies labeled classical LBs in substantia nigra sections from four related human disorders: sporadic PD, inherited ?S-linked PD, dementia with LBs (DLB), and LB-positive, parkin-linked PD. Anti-parkin antibodies also detected LBs in entorhinal and cingulate cortices from DLB brain and ?S inclusions in sympathetic gangliocytes from sporadic PD. Double labeling with confocal microscopy of DLB midbrain sections revealed that ?90% of anti-?S-reactive LBs were also detected by a parkin antibody to amino acids 342 to 353. Accordingly, parkin proteins, including the 53-kd mature isoform, were present in affinity-isolated LBs from DLB cortex. Fluorescence resonance energy transfer and immunoelectron microscopy showed that ?S and parkin co-localized within brainstem and cortical LBs. Biochemically, parkin appeared most enriched in cytosolic and postsynaptic fractions of adult rat brain, but also in purified, ?S-rich presynaptic elements that additionally contained parkin’s E2-binding partner, UbcH7. We conclude that parkin and UbcH7 are present with ?S in subcellular compartments of normal brain and that parkin frequently co-localizes with ?S aggregates in the characteristic LB inclusions of PD and DLB. These results suggest that functional parkin proteins may be required during LB formation.

Schlossmacher, Michael G.; Frosch, Matthew P.; Gai, Wei Ping; Medina, Miguel; Sharma, Nutan; Forno, Lysia; Ochiishi, Tomoyo; Shimura, Hideki; Sharon, Ronit; Hattori, Nobutaka; Langston, J. William; Mizuno, Yoshikuni; Hyman, Bradley T.; Selkoe, Dennis J.; Kosik, Kenneth S.

2002-01-01

241

ECOLOGICAL COMMUNITY SURVEYS WITHIN THE RED RIVER-DEVILS LAKE BASIN-GRIGGS AND NELSON COUNTIES. EPA-REGIONAL GEOGRAPHIC INITIATIVE  

EPA Science Inventory

Utilize funding from the Regional Geographic Initiative Program to conduct a survey of ecological communities within the Red River-Devils Lake Basins. The study will be targeting Griggs and Nelson Counties to identify significant natural communities and to collect and interpret n...

242

Anthropogenic Influences on Geogenic Trace Elements and Contamination in Wash Sediments from Historical Mining Activities in the Carnation Wash System, Nelson, Nevada (USA)  

Microsoft Academic Search

This study examines contamination from abandoned mine mill waste in the sediments of the Carnation Wash system, Nelson, NV. The Carnation Wash was chosen because only one milling site is located near the head of the wash system. This is the only mill facility located within the wash or surrounding area of the wash and therefore, this mill is the

Douglas Brian Sims; Anthony Francis

2010-01-01

243

Genus Microsternus Lewis (1887) from China, with description of a new genus Neosternus from Asia (Coleoptera, Erotylidae, Dacnini)  

PubMed Central

Abstract This work treats species of the genus Microsternus Lewis, 1887 from Asia and North America. A new genus is described: Neosternus (type species Microsternus higonius Lewis, 1887). A new species is described: Microsternus pengzhongi. A new synonym is provided: Microsternus tricolor taiwanicus Nakane (=Microsternus tricolor Lewis). Three species previously placed in Microsternus Lewis, 1887 are transferred to Neosternus resulting in the following three new combinations: Neosternus higonius (Lewis, 1887), Neosternus taiwanus (Chûjô, 1976), and Neosternus hisamatsui (Nakane, 1981).

Dai, Cong-Chao; Zhao, Mei-Jun

2013-01-01

244

Familial Dementia With Lewy Bodies With an Atypical Clinical Presentation  

PubMed Central

The authors report a case of a 64-year-old male with Alzheimer’s disease (AD) and dementia with Lewy bodies (DLB) pathology at autopsy who did not manifest the core symptoms of DLB until very late in his clinical course. His initial presentation of early executive and language dysfunction suggested a cortical dementia similar to frontotemporal lobar degeneration (FTLD). Core symptoms of DLB including dementia, hallucination, and parkinsonian symptoms were not apparent until late in the course of his illness. Autopsy revealed both brainstem and cortical Lewy bodies and AD pathology. Family history revealed 7 relatives with a history of dementia including 4 with possible or probable DLB. This case is unique because of the FTLD-like presentation, positive family history of dementia, and autopsy confirmation of DLB.

Bonner, Lauren T.; Tsuang, Debby W.; Cherrier, Monique M.; Eugenio, Charisma J.; Du, Jennifer Q.; Steinbart, Ellen J.; Limprasert, Pornprot; La Spada, Albert R.; Seltzer, Benjamin; Bird, Thomas D.; Leverenz, James B.

2006-01-01

245

DIFFICULTY PROCESSING TEMPORARY SYNTACTIC AMBIGUITIES IN LEWY BODY SPECTRUM DISORDER  

PubMed Central

While grammatical aspects of language are preserved, executive deficits are prominent in Lewy body spectrum disorder (LBSD), including Parkinson’s disease (PD), Parkinson’s dementia (PDD) and dementia with Lewy bodies (DLB). We examined executive control during sentence processing in LBSD by assessing temporary structural ambiguities. Using an on-line word detection procedure, patients heard sentences with a syntactic structure that has high-compatibility or low-compatibility with the main verb’s statistically preferred syntactic structure, and half of the sentences were lengthened strategically between the onset of the ambiguity and its resolution. We found selectively slowed processing of lengthened ambiguous sentences in the PDD/DLB subgroup. This correlated with impairments on measures of executive control. Regression analyses related the working memory deficit during ambiguous sentence processing to significant cortical thinning in frontal and parietal regions. These findings emphasize the role of prefrontal disease in the executive limitations that interfere with processing ambiguous sentences in LBSD.

Grossman, Murray; Gross, Rachel G.; Moore, Peachie; Dreyfuss, Michael; McMillan, Corey; Cook, Philip; Ash, Sherry; Siderowf, Andrew

2011-01-01

246

The biosynthesis of Lewis X in Helicobacter pylori.  

PubMed

The biosynthesis of the Lewis X determinant (Gal beta 1-4 [Fuc alpha 1-3]GlcNAc beta-) in three strains of Helicobacter pylori has been investigated. Strains UA 861, UA 802 and UA 1182 contain alpha 1,3 fucosyltransferase and beta 1,4 galactosyltransferase activities that synthesize the Lewis X structure by the transfer of monosaccharides from GDP-fucose and UDP-galactose donors, respectively. The enzyme reaction products that formed were characterized by capillary zone electrophoresis and by 1H-NMR spectroscopy. The biosynthetic pathway is therefore identical to that found in humans. In the three strains, the fucosyltransferase and galactosyltransferase activities differed in various cellular fractions. Km values for their donor and acceptor substrates also differed. PMID:8608270

Chan, N W; Stangier, K; Sherburne, R; Taylor, D E; Zhang, Y; Dovichi, N J; Palcic, M M

1995-10-01

247

Diffuse Lewy body disease: clinical features in 15 cases.  

PubMed Central

Fifteen cases of diffuse Lewy body disease were diagnosed on pathological grounds during a single year in one health district. The range and frequency of clinical features contrast strikingly with previous reports. The majority of cases presented with classical levodopa-responsive Parkinson's disease either alone (6 cases) or with mild cognitive impairment (3 cases); the remaining 6 cases presented with cognitive impairment alone. In time almost all patients developed both dementia and Parkinsonism. The dementia was cortical in type, but unusual in that most (12 cases) showed day-to-day fluctuation in severity at some point in their illness. These findings suggest that diffuse Lewy body disease is not rare, and that it presents in a range of ways from dementia with subsequent Parkinsonism to Parkinson's disease with subsequent dementia. The latter mode of presentation suggests that it should be considered as a significant pathological substrate of dementia in Parkinson's disease. Images

Byrne, E J; Lennox, G; Lowe, J; Godwin-Austen, R B

1989-01-01

248

[The effect of psychoemotional state on Lewis lung carcinoma metastasis].  

PubMed

The effect of a depression-like status formed by chronic stress on development of Lewis lung carcinoma metastases in C57Bl/6J mice was investigated. Two types of acute stress (restraint and social stress) were used for comparison. The depression-like status was induced by eight-week exposure to repeated but unpredictable stressors (chronic mild stress model) and was assessed in the forced swim test. Tumor cells were inoculated an hour after the onset of social stressor or immediately after physical or chronic stressor impacts. The number of metastases was counted 17 days after the inoculation. The results indicate that chronic mild stress provokes the development of a depression-like state in mice and causes a twofold increase in the number of metastases in the lungs, while both types of acute stress have no such effects. Thus, a depression-like psychoemotional status of animals enhances the metastasis of Lewis lung carcinoma. PMID:22645951

Amikashieva, A V; Il'nitskaia, S I; Nikolin, V P; Popova, N A; Kaledin, V I

2012-03-01

249

A comparative analysis of simulated and observed landslide locations triggered by Hurricane Camille in Nelson County, Virginia  

USGS Publications Warehouse

In 1969, Nelson County, Virginia received up to 71 cm of rain within 12 h starting at 7 p.m. on August 19. The total rainfall from the storm exceeded the 1000-year return period in the region. Several thousands of landslides were induced by rainfall associated with Hurricane Camille causing fatalities and destroying infrastructure. We apply a distributed transient response model for regional slope stability analysis to shallow landslides. Initiation points of over 3000 debris flows and effects of flooding from this storm are applied to the model. Geotechnical data used in the calculations are published data from samples of colluvium. Results from these calculations are compared with field observations such as landslide trigger location and timing of debris flows to assess how well the model predicts the spatial and temporal distribution. of landslide initiation locations. The model predicts many of the initiation locations in areas where debris flows are observed. Copyright ?? 2007 John Wiley & Sons, Ltd.

Morrissey, M. M.; Wieczorek, G. F.; Morgan, B. A.

2008-01-01

250

Clay-Rich Gouge Identified in Serpentinite from the San Andreas Fault Zone at Nelson Creek, Monterey County, California  

NASA Astrophysics Data System (ADS)

A clay-rich gouge has been found in an outcrop of serpentinite along the San Andreas fault at Nelson Creek, about 2.4 km NNE of the San Andreas Fault Observatory at Depth (SAFOD). A small section of the clayey gouge, about 0.15 m wide and 0.5 m long, is exposed along a fault trace that slipped during the 2004 Parkfield earthquake and that juxtaposes the serpentinite against sandstone. The serpentinite body is 3-50 m wide and extends along the fault as a tectonic smear for at least 4 to 5 km. The clay-rich, foliated gouge contains clasts of serpentinite, shale, siltstone, quartz, albite, and K-feldspar. Based on electron microprobe analyses, clay minerals in the matrix of the gouge are saponitic smectite clays containing on average 24-25 wt% MgO and ~7 wt% Al2O3. The Mg-rich clay compositions combined with textural evidence suggest that the gouge is the product of metasomatic reaction between the Mg-rich serpentinite and adjoining quartzofeldspathic sedimentary rocks. Serpentinite-bearing clayey gouge has also been identified in Phase 3 SAFOD core recovered from the two actively creeping traces of the San Andreas fault at ~3190 m and ~3300 m measured depth (MD). Phase 2 SAFOD cuttings associated with the 3190 m active trace were examined for comparison with the Nelson Creek samples. Cuttings of foliated clays containing serpentinite grains were identified in cuttings samples beginning at 3197 m MD, and these are inferred to represent the foliated fault gouge of the 3190 m active trace. Many of the clays in the grains of gouge also have saponitic compositions. Other clays with higher Al/Si and Fe/Mg ratios are more consistent with corrensite, a regularly interlayered chlorite-smectite clay. In the few grains in which both clays were identified, the saponite appears to be younger than the corrensitic clay. We conclude that the clayey gouge in the Nelson Creek outcrop is equivalent to that found at ~2700 m (true depth) in the actively creeping strands of the San Andreas fault at SAFOD. The presence of the clayey gouge in outcrop may indicate connection with one or both of the gouge zones at depth — if so, we may find similar gouge, and evidence of fault processes, at depths in between. In burial diagenetic environments, a progression from trioctahedral smectite, to corrensite, to chlorite occurs with increasing depth and temperature. The differences in clay-mineral assemblages of the Nelson Creek and SAFOD gouges are consistent with their different depths of occurrence. The overprinting of corrensite by saponite observed in some SAFOD grains may indicate a gradual upward migration of material in the active fault traces over time.

Moore, D. E.; Rymer, M. J.

2009-12-01

251

Asymptotic Analysis of Laminar Flame Propagation for General Lewis Numbers  

Microsoft Academic Search

The structure of a steady one-dimensional isobaric deflagration is examined for the case of a direct first-order one-step irreversible exothermic unimolecular decomposition under Arrhenius kinetics. In particular, the eigenvalue giving the speed of propagation of the laminar flame into the unburned gas is sought for constant Lewis number of order unity. The method of matched asymptotic expansion is invoked in

WILLIAM B. BUSH; FRANCIS E. FENDELL

1970-01-01

252

Familial Dementia with Lewy Bodies with an Atypical Clinical Presentation  

Microsoft Academic Search

The authors report a case of a 64-year-old male with Alzheimer’s disease (AD) and dementia with Lewy bodies (DLB) pathology at autopsy who did not manifest the core symptoms of DLB until very late in his clinical course. His initial presentation of early executive and language dysfunction suggested a cortical dementia similar to frontotemporal lobar degeneration (FTLD). Core symptoms of

Lauren T. Bonner; Debby W. Tsuang; Monique M. Cherrier; Charisma J. Eugenio; Jennifer Q. Du; Ellen J. Steinbart; Pornprot Limprasert; Albert R. La Spada; Benjamin Seltzer; Thomas D. Bird; James B. Leverenz

2003-01-01

253

Adult Polyglucosan Body Disease Associated With Lewy Bodies and Tremor  

Microsoft Academic Search

Background:Adultpolyglucosanbodydisease(PGBD) is rare and typically presents with upper and lower motor neuron involvement and neurogenic bladder. Extrapyra- midalfeaturesareunusualinPGBDandarepresumedsec- ondary to widespread pathology that includes the basal ganglia.TherearenopriorreportsofLewybodiesinPGBD. Objective: To report a unique finding of Lewy bodies in a patient with PGBD. Report of a Case: A 46-year-old woman initially pre- sentedwitha4-yearhistoryofrestingtremor.Thetremor responded to levodopa therapy. Several months later, she developedupperandlowermotorneuroninvolvementand

Jaya R. Trivedi; Gil I. Wolfe; Sharon P. Nations; Dennis K. Burns; Wilson W. Bryan; Richard B. Dewey

2003-01-01

254

Otolaryngologic aspects of the Lewis & Clark Expedition, 1803-1806.  

PubMed

Medical difficulties related to otolaryngology that occurred during the Lewis & Clark Expedition (1803-1806) are highlighted. These difficulties included ear and face frostbite, upper respiratory infections, temporal vessel laceration from an air gun accident, neck scrofula, and a pediatric neck mass. The custom of Clatsop Indian head flattening is also described. These descriptions also aim to illustrate the state of otolaryngology during the early 19th century in America. PMID:12160275

Eisen, Marc D; Lustig, Lawrence R

2002-06-01

255

Survey on Cosmogenic 26Al in Lewis Cliff Meteorites  

Microsoft Academic Search

INTRODUCTION: We have embarked upon a ^26Al gamma-ray survey of meteorites selected from about 2000 samples recently recovered from the Lewis Cliff Ice Fields (84 degrees 18'S\\/161 degrees 20'E). Due to its 705-ka half-life ^26Al can be used for estimating terrestrial ages and thus contribute to further characterization of Antarctic meteorites in addition to their classification and thermoluminescence (TL) properties.

K. C. Welten; C. Alderliesten; L. Lindner

1992-01-01

256

Ion thruster development at NASA Lewis Research Center  

NASA Astrophysics Data System (ADS)

Recent ion propulsion technology efforts at NASA's Lewis Research Center including development of kW-class xenon ion thrusters, high power xenon and krypton ion thrusters, and power processors are reviewed. Thruster physical characteristics, performance data, life projections, and power processor component technology are summarized. The ion propulsion technology program is structured to address a broad set of mission applications from satellite stationkeeping and repositioning to primary propulsion using solar or nuclear power systems.

Sovey, James S.; Hamley, John A.; Patterson, Michael J.; Rawlin, Vincent K.; Sarver-Verhey, Timothy R.

1992-12-01

257

Lewis and Clark: Pioneering Meteorological Observers in the American West.  

NASA Astrophysics Data System (ADS)

The technical achievements of Lewis and Clark have been celebrated in fields ranging from cartography to zoology. As America commemorates the bicentennial of their historic journey across the continent, this paper shows that their meteorological data and personal weather-related observations also are worthy of celebration. While the primary goal of the mission, as described by then-President Jefferson to the Congress, was economic and strategic, both Jefferson and cocaptains Lewis and Clark showed an interest in and capacity for scientific understanding of the meteorology of the then-unknown West. The seasonal evolution and variability of temperatures recorded for the first time by Lewis and Clark on the High Plains can now be shown to be quite close to average, thanks to many decades of collection of modern data by the U.S. Cooperative Observer Network stations along their route. While the diets, lives, and experiences of these early explorers and their men were profoundly different from those of modern Americans, the climate that they documented for the first time with care and accuracy remains familiar to us today.

Solomon, Susan; Daniel, John S.

2004-09-01

258

Sex differences in circulating and renal angiotensins of hypertensive mRen(2). Lewis but not normotensive Lewis rats.  

PubMed

Sex differences in blood pressure are evident in experimental models and human subjects, yet the mechanisms underlying this disparity remain equivocal. The current study sought to define the extent of male-female differences in the circulating and tissue renin-angiotensin aldosterone systems (RAASs) of congenic mRen(2). Lewis and control Lewis rats. Male congenics exhibited higher systolic blood pressure than females [200 +/- 4 vs. 146 +/- 7 mmHg, P < 0.01] or Lewis males and females [113 +/- 2 vs. 112 +/- 2 mmHg, P > 0.05]. Plasma ANG II levels were twofold higher in male congenics [47 +/- 3 vs. 19 +/- 3 pM, P < 0.01] and fivefold higher than in male or female Lewis rats [6 +/- 1 vs. 6 +/- 1 pM]. ANG I levels were also highest in the males; however, plasma ANG-(1-7) was higher in female congenics. Male congenics exhibited greater circulating renin and angiotensin-converting enzyme (ACE) activities, as well as angiotensinogen, than female littermates. Renal cortical and medullary ANG II levels were also higher in the male congenics versus all the other groups; ANG I was lower in the males. Cortical ACE2 activity was higher in male congenics, yet neprilysin activity and protein were greater in the females, which may contribute to reduced renal levels of ANG II. These data reveal that sex differences in both the circulating and renal RAAS are apparent primarily in the hypertensive group. The enhanced activity of the RAAS in male congenics may contribute to the higher pressure and tissue injury evident in the strain. PMID:18456730

Pendergrass, Karl D; Pirro, Nancy T; Westwood, Brian M; Ferrario, Carlos M; Brosnihan, K Bridget; Chappell, Mark C

2008-05-02

259

CURRICULUM VITAE  

Center for Biologics Evaluation and Research (CBER)

Text Version... Kong, Thailand, Malaysia and India, preparing an Asia-Pacific clinical ... and presentations, publication teams, competitive intelligence, congress data ... More results from www.fda.gov/downloads/advisorycommittees/committeesmeetingmaterials

260

CURRICULUM VITAE  

Center for Biologics Evaluation and Research (CBER)

Text Version... 31. 12/10/96 - International Business Conference on Drug Interactions Bethesda, MD Topic: The mechanistic basis for the grapefruit juice effect. 32. ... More results from www.fda.gov/downloads/advisorycommittees/committeesmeetingmaterials

261

CURRICULUM VITAE  

Center for Biologics Evaluation and Research (CBER)

Text Version... 3. PLACE OF BIRTH: ... 1990 – 2006 National Jewish Medical Research Center Denver ... Immune Deficiency Disorders, Best Practices, Northbrook, IL ... More results from www.fda.gov/downloads/advisorycommittees/committeesmeetingmaterials

262

CURRICULUM VITAE  

Center for Biologics Evaluation and Research (CBER)

Text Version... Inhibition of DNA helicase II unwinding and ATPase activities by DNA interacting ... The role of ultrasound in diagnosis and management of fetal IUGR ... More results from www.fda.gov/downloads/advisorycommittees/committeesmeetingmaterials

263

Curriculum Vitae  

Center for Biologics Evaluation and Research (CBER)

Text Version... 9003 Small Animal Gastroenterology, 1978-79. ... 14th Annual Veterinary Medical Forum ... San Antonio, TX, 1996, p 749 and J Vet Int Med 10:167, 1996 ... More results from www.fda.gov/downloads/advisorycommittees/committeesmeetingmaterials

264

CURRICULUM VITAE  

Center for Biologics Evaluation and Research (CBER)

Text Version... and cancer Management of Inflammatory Bowel Disease Development of improved biliary stents resistant to encrustation with bacterial biofilm. ... More results from www.fda.gov/downloads/advisorycommittees/committeesmeetingmaterials

265

CURRICULUM VITAE  

Center for Biologics Evaluation and Research (CBER)

Text Version... at P183 of emerin weaken its protein-protein interactions resulting in X-linked Emery-Dreifuss muscular dystrophy", Human Genetics, 104(3): 262 ... More results from www.fda.gov/downloads/advisorycommittees/committeesmeetingmaterials

266

CURRICULUM VITAE  

Center for Biologics Evaluation and Research (CBER)

Text Version... of the International Oral Health Crisis,” Washington Global ... “Caries management by Risk ... Dentistry for Children,” Guang Zhou, China; January, 21 ... More results from www.fda.gov/downloads/advisorycommittees/committeesmeetingmaterials

267

CURRICULUM VITAE  

Center for Biologics Evaluation and Research (CBER)

Text Version... 1990 Harris Laboratories, Lincoln, Nebraska ... Education Center, Cleveland, Ohio; and Harpers Ferry, West Virginia. ... Baltimore VA Medical Center ... More results from www.fda.gov/downloads/advisorycommittees/committeesmeetingmaterials

268

CURRICULUM VITAE  

Center for Biologics Evaluation and Research (CBER)

Text Version... SPIE Medical Imaging 2000-2006 Member, Image Processing Scientific Program Committee, Annual SPIE Medical Imaging Symposium, San Diego ... More results from www.fda.gov/downloads/advisorycommittees/committeesmeetingmaterials

269

CURRICULUM VITAE  

Center for Biologics Evaluation and Research (CBER)

Text Version... PUBLICATIONS Original Articles Welch, DF, and MT Kelly. 1979. ... J. Clin. Microbiol. 9:520-524. Welch, DF, and MT Kelly. 1979. ... More results from www.fda.gov/downloads/advisorycommittees/committeesmeetingmaterials

270

CURRICULUM VITAE  

Center for Biologics Evaluation and Research (CBER)

Text Version... 1987 - 1993) Owl Drugs Drayton Plains, Michigan Part-Time Community Pharmacist (1977 - 1990) Geriatrics, Inc. Bloomfield ... More results from www.fda.gov/downloads/advisorycommittees/committeesmeetingmaterials

271

CURRICULUM VITAE  

Center for Biologics Evaluation and Research (CBER)

Text Version... Pathology Oncology Research. 15(1):81-8, 2009 Mar. 166. ... 168. Frick AC. Falcone T. Robotics in gynecologic surgery. Minerva Ginecologica. ... More results from www.fda.gov/downloads/advisorycommittees/committeesmeetingmaterials

272

CURRICULUM VITAE  

Center for Biologics Evaluation and Research (CBER)

Text Version... Education, cognitive function, and severity of neuropathology in ... Statistical Methods for Analysis of Health Care ... in the Presence of Verification Bias. ... More results from www.fda.gov/downloads/advisorycommittees/committeesmeetingmaterials

273

CURRICULUM VITAE  

Center for Biologics Evaluation and Research (CBER)

Text Version... vision for state motor vehicle departments, 2008. ... C. Incidence of emergency department treated eye ... A. Effect of refractive error correction on health ... More results from www.fda.gov/downloads/advisorycommittees/committeesmeetingmaterials

274

CURRICULUM VITAE  

Center for Biologics Evaluation and Research (CBER)

Text Version... Boucher, CA, Block, PC, Strauss, HW, Pohost, GM:"Radionuclide determined change in pulmonary blood-volume with exercise improved sensitivity ... More results from www.fda.gov/downloads/advisorycommittees/committeesmeetingmaterials

275

Curriculum Vitae  

Center for Biologics Evaluation and Research (CBER)

Text Version... 43. Kim SH, Munemasa Y, Kwong JM, Ahn JH, Mareninov S, Gordon LK, Caprioli J, Piri N. Activation of autophagy in retinal ganglion cells. ... More results from www.fda.gov/downloads/advisorycommittees/committeesmeetingmaterials

276

CURRICULUM VITAE  

Center for Biologics Evaluation and Research (CBER)

Text Version... A retrospective study of post craniotomy headaches ... protocol for traumatic spinal cord ... Syringomyelia in mucopolysaccharidosis type VI (Maroteaux ... More results from www.fda.gov/downloads/advisorycommittees/committeesmeetingmaterials

277

CURRICULUM VITAE  

Center for Biologics Evaluation and Research (CBER)

Text Version... removal from human macrophage foam cells ... Raloxifene, a Selective Estrogen Receptor Modulator ... on the basolateral surface of hepatocytes. ... More results from www.fda.gov/downloads/advisorycommittees/committeesmeetingmaterials

278

Curriculum Vitae  

Center for Biologics Evaluation and Research (CBER)

Text Version... for Monitoring the Mean Vector in Autocorrelated ... Institute of Industrial Engineers (IIE) ? Engineering Economy Division: President (2003), Program ... More results from www.fda.gov/downloads/advisorycommittees/committeesmeetingmaterials

279

CURRICULUM VITAE  

Center for Biologics Evaluation and Research (CBER)

Text Version... Anti-oxidant inhibition of hyaluronan fragment-induced inflammatory gene expression J Inflamm (Lond). 2008 Nov 5;5:20. PMCID: PMC2627834. ... More results from www.fda.gov/downloads/advisorycommittees/committeesmeetingmaterials

280

Curriculum Vitae  

Center for Biologics Evaluation and Research (CBER)

Text Version... 2008; San Juan, Puerto Rico. Pisarik P. Reversibility of FEV1 in acute cough illness. Presented at: Annual Meeting of the ... More results from www.fda.gov/downloads/advisorycommittees/committeesmeetingmaterials

281

CURRICULUM VITA  

Center for Biologics Evaluation and Research (CBER)

Text Version... Increased energy expenditure associated with repetitive involuntary movement does not contribute ... 3. Solar-Alfonso C, Motil KJ, Robbbins-Furman P ... More results from www.fda.gov/downloads/advisorycommittees/committeesmeetingmaterials

282

CURRICULUM VITAE  

Center for Biologics Evaluation and Research (CBER)

Text Version... 10. Aulerich, RJ, Bursian, SJ, Poppenga, RH, Mullaney, TP, and Braselton, WE (1991): Toleration of high concentrations of dietary zinc by mink. ... More results from www.fda.gov/downloads/advisorycommittees/committeesmeetingmaterials

283

CURRICULUM VITAE  

Center for Biologics Evaluation and Research (CBER)

Text Version... George K, Kao SY, Allega J, Tan B, LaFontaine R, Bui L, and Rinaldo CR. ... George K, Allega J, Bullotta AC, Gilbane L, and Rinaldo CR. ... More results from www.fda.gov/downloads/advisorycommittees/committeesmeetingmaterials

284

CURRICULUM VITAE  

Center for Biologics Evaluation and Research (CBER)

Text Version... Committee Activities: Institutional Georgetown: 1988-1993, Committee on Clinical Competence, Georgetown University Hospital, Washington, DC ... More results from www.fda.gov/downloads/advisorycommittees/committeesmeetingmaterials

285

Curriculum Vitae  

Center for Biologics Evaluation and Research (CBER)

Text Version... Heart, Hypertension, Diabetes, and Lipids: Therapeutic Advances, Dallas, TX November 17, 2007 Diabetes & Cardiovascular Care: Recent ... More results from www.fda.gov/downloads/advisorycommittees/committeesmeetingmaterials

286

CURRICULUM VITAE  

Center for Biologics Evaluation and Research (CBER)

Text Version... Performance and developmental stability of triploid tiger trout (Salmo trutta x ... to establish captive breeding priorities for endangered Snake River ... More results from www.fda.gov/downloads/advisorycommittees/committeesmeetingmaterials

287

CURRICULUM VITAE  

Center for Biologics Evaluation and Research (CBER)

Text Version... Radiation Research Clinical Chemistry Genetics in Medicine American Journal of Human Genetics Journal of Molecular Diagnostics Genetic ... More results from www.fda.gov/downloads/advisorycommittees/committeesmeetingmaterials

288

Curriculum Vitae  

Center for Biologics Evaluation and Research (CBER)

Text Version... PA, Boone JL, Jackson R, Wester D, Hoffer ME, Lambert DC, Charon CC, Ding DL, McBride D. Reduction of noise induced hearing loss using L ... More results from www.fda.gov/downloads/advisorycommittees/committeesmeetingmaterials

289

CURRICULUM VITAE  

Center for Biologics Evaluation and Research (CBER)

Text Version... of Biochemistry and Molecular Biology, BMSB 840 PO Box 26901 Oklahoma City OK 73190 ... (Hons) in Biochemistry, -b(6)-. ... More results from www.fda.gov/downloads/advisorycommittees/committeesmeetingmaterials

290

CURRICULUM VITAE  

Center for Biologics Evaluation and Research (CBER)

Text Version... on Biopersistence of Respirable Synthetic Fibers and Minerals- Lyon, France. ... Fifth International Workshop on the Effects of Mineral Dusts on Cells ... More results from www.fda.gov/downloads/advisorycommittees/committeesmeetingmaterials

291

Curriculum Vitae  

Center for Biologics Evaluation and Research (CBER)

Text Version... and national health education, prevention and intervention programs for diverse communities in Health Lungs, Mental Health and Pediatric ... More results from www.fda.gov/downloads/advisorycommittees/committeesmeetingmaterials

292

CURRICULUM VITAE  

Center for Biologics Evaluation and Research (CBER)

Text Version... 31. Laskey MA, Deutsch E, Barnathan E, Laskey WK: Influence of heparin therapy on PTCA outcome in unstable angina. ... More results from www.fda.gov/downloads/advisorycommittees/committeesmeetingmaterials

293

CURRICULUM VITAE  

Center for Biologics Evaluation and Research (CBER)

Text Version... Peer-Reviewed Papers 1. Afifi, AA and Elashoff, RM: “Missing Observations in Multivariate Statistics I. Review of the Literature.” Journal of ... More results from www.fda.gov/downloads/advisorycommittees/committeesmeetingmaterials

294

CURRICULUM VITAE  

Center for Biologics Evaluation and Research (CBER)

Text Version... food animals, resistance issues in food animals, using the ... antimicrobial decision support system to assist in food animal antimicrobial selections ... More results from www.fda.gov/downloads/advisorycommittees/committeesmeetingmaterials

295

Curriculum Vitae  

Center for Biologics Evaluation and Research (CBER)

Text Version... Staff, The Genetic Centers of America Centers involved in evaluating and treat several hundred patients with autism, neurodevelopmental disorders ... More results from www.fda.gov/downloads/advisorycommittees/committeesmeetingmaterials

296

CURRICULUM VITAE  

Center for Biologics Evaluation and Research (CBER)

Text Version... [Abstracted in Breast Diseases: A Year Book Quarterly] Sept 1994. 18. ... Breast Diseases: A Yearbook Quarterly 6(1):112-114, Apr-Jun 1995. ... More results from www.fda.gov/downloads/advisorycommittees/committeesmeetingmaterials

297

CURRICULUM VITAE  

Center for Biologics Evaluation and Research (CBER)

Text Version... Disorder Presenting in the Head & Neck PRESENTATION: Germline ... of Adeno-Associated Virus Mediated Introduction of Brain Derived Nerve ... More results from www.fda.gov/downloads/advisorycommittees/committeesmeetingmaterials

298

Curriculum Vitae  

Center for Biologics Evaluation and Research (CBER)

Text Version... production reports. • Performed internal audits of the Product Development Units at George Washington University as well ... More results from www.fda.gov/downloads/advisorycommittees/committeesmeetingmaterials

299

Radical polymerization of di- n-butyl itaconate in the presence of Lewis acids  

Microsoft Academic Search

Intramolecular chain-transfer reaction takes place in polymerizations of itaconates at high temperatures and\\/or at low monomer concentrations. Polymerizations of di-n-butyl itaconate (DBI) were carried out at 60 °C in the presence of Lewis acids such as scandium trifluoromethansulfonate. Lewis acids hardly influenced the intramolecular chain-transfer reaction in bulk polymerizations. Polymerizations in methanol accompanied transesterification reaction catalyzed by Lewis acids. In

Tomohiro Hirano; Kousuke Higashi; Makiko Seno; Tsuneyuki Sato

2003-01-01

300

Lewis x is highly expressed in normal tissues: A comparative immunohistochemical study and literature revision  

Microsoft Academic Search

An immunohistochemical analysis was employed to determine the expression of carbohydrate antigens associated to mucins in\\u000a normal epithelia. Tissue samples were obtained as biopsies from normal breast (18), colon (35) and oral cavity mucosa (8).\\u000a The following carbohydrate epitopes were studied: sialyl-Lewis x, Lewis x, Lewis y, Tn hapten, sialyl-Tn and Thomsen-Friedenreich\\u000a antigen. Mucins were also studied employing antibodies against

María V. Croce; Marina Isla-Larrain; Martín E. Rabassa; Sandra Demichelis; Andrea G. Colussi; Marina Crespo; Ezequiel Lacunza; Amada Segal-Eiras

2007-01-01

301

A transition metal Lewis acid/base triad system for cooperative substrate binding.  

PubMed

A frustrated Lewis pair accessory functionality is positioned in the secondary coordination sphere of a terpyridine ligand (Tpy(BN) = 6-morpholino-2,2':6',2?-terpyridine-6?-boronic acid pinacol ester) to promote directed Lewis acid/base interactions. Following metalation with VCl3, the utility of the metal Lewis acid/base triad (LABT) is highlighted with N2H4 as a cooperatively coordinated substrate, affording the first ?(2)-[N2H3](-) vanadium complex. PMID:23421523

Tutusaus, Oscar; Ni, Chengbao; Szymczak, Nathaniel K

2013-02-25

302

Accuracy of shade matching performed by colour blind and normal dental students using 3D Master and Vita Lumin shade guides.  

PubMed

The purpose of this study was to investigate whether 3D Master or VitaLumin shade guides could improve colour selection in individuals with normal and defective colour vision. First, colour perception of 260 dental students was evaluated. Afterwards, 9 colour blind and 9 matched normal subjects tried to detect colours of 10 randomly selected tabs from each kit and the correct/false answers were counted. Of the colour-defective subjects, 47.8% and 33.3% correctly detected the shade using 3D Master and VitaLumin, respectively. These statistics were 62.2% and 42.2% in normal subjects. In normal participants, but not in colour blind ones, 3D Master significantly improved shade matching accuracy compared to VitaLumin. PMID:22474932

Vafaee, F; Rakhshan, V; Vafaei, M; Khoshhal, M

2012-03-01

303

Hypersonic engine seal development at NASA Lewis Research Center  

NASA Astrophysics Data System (ADS)

NASA Lewis Research Center is developing advanced seal concepts and sealing technology for advanced combined cycle ramjet/scramjet engines being designed for the National Aerospace Plane (NASP). Technologies are being developed for both the dynamic seals that seal the sliding interfaces between articulating engine panels and sidewalls, and for the static seals that seal the heat exchanger to back-up structure interfaces. This viewgraph presentation provides an overview of the candidate engine seal concepts, seal material assessments, and unique test facilities used to assess the leakage and thermal performance of the seal concepts.

Steinetz, Bruce M.

1994-07-01

304

Lewis structures technology, 1988. Volume 2: structural mechanics  

SciTech Connect

Lewis Structures Div. performs and disseminates results of research conducted in support of aerospace engine structures. These results have a wide range of applicability to practitioners of structural engineering mechanics beyond the aerospace arena. The engineering community was familiarized with the depth and range of research performed by the division and its academic and industrial partners. Sessions covered vibration control, fracture mechanics, ceramic component reliability, parallel computing, nondestructive evaluation, constitutive models and experimental capabilities, dynamic systems, fatigue and damage, wind turbines, hot section technology (HOST), aeroelasticity, structural mechanics codes, computational methods for dynamics, structural optimization, and applications of structural dynamics, and structural mechanics computer codes.

Not Available

1988-05-01

305

Genetic variation in the choline O-acetyltransferase gene in depression and Alzheimer's disease: the VITA and Milano studies.  

PubMed

Linkage studies point to the long arm of chromosome 10 being a susceptibility region for Alzheimer's disease (AD). Additionally, the gene choline O-acetyltransferase (CHAT) located on chromosome 10 was discussed for conveying risk towards AD, but the results are ambiguous. We examined a possible association of nineteen single-nucleotide polymorphisms (SNPs) in the CHAT gene in a longitudinal cohort study, the Vienna Tansdanube Aging (VITA)-study, in which all subjects were 75 years old at baseline. For replication, we used a more heterogeneous case-control sample from Milano with early and late AD. Nominal allelic and genotypic associations with AD risk in the cross-sectional VITA sample were found for rs3810950 (p = 0.038 for genotype, OR = 1.66 95% CI 1.03-2.68, p = 0.052 allele-wise). When combining both VITA- and Milano study rs3810950 was significantly associated with AD (p(combined) = 0.01634; power = 82%). This association was highly significant for APOE?4 carriers (p = 0.009 for genotype, OR = 3.21 95% CI 1.43-7.19 p = 0.007 allele-wise). Furthermore, an association of rs1880676 with AD was specific to carriers of the APOE?4 risk allele (p = 0.008, genotype; OR = 3.47 95% CI 1.50-8.01 p = 0.005 allele-wise). For depressive symptoms, we found a nominally significant association of rs3810950 with minor and major depression (p = 0.023, genotype; p = 0.008, allele). Applying Benjamini and Hochberg correction these associations could not be confirmed and also not be replicated in the more heterogeneous Milano sample. While our data therefore do not seem to support a major role for CHAT genetic variation in geriatric depression and AD, there might be a minor contribution in geriatric patients with depression and late onset AD, in particular those carrying the APOE?4 genotype. PMID:21507424

Grünblatt, Edna; Reif, Andreas; Jungwirth, Susanne; Galimberti, Daniela; Weber, Heike; Scarpini, Elio; Sauer, Cathrin; Wichart, Ildiko; Rainer, Michael K; Huber, Klaus; Danielczyk, Walter; Tragl, Karl H; Deckert, Jürgen; Fischer, Peter; Riederer, Peter

2011-04-19

306

True Grit: In Tracking down the Real Story of a Legendary Hero of the Old West, Vaunda Micheaux Nelson also Nabbed the Coretta Scott King Award  

ERIC Educational Resources Information Center

|When Vaunda Micheaux Nelson donned a black Stetson to become the biographer of Deputy U.S. Marshal Bass Reeves, she had no idea that her square-shooting book about an unsung African-American hero of the Old West would win over a posse of fans and earn her the prestigious 2010 Coretta Scott King (CSK) Author Award. "Bad News for Outlaws" (Lerner,…

Fleishhacker, Joy

2010-01-01

307

Impairments of Speech Fluency in Lewy Body Spectrum Disorder  

PubMed Central

Few studies have examined connected speech in demented and non-demented patients with Parkinson’s disease (PD). We assessed the speech production of 35 patients with Lewy body spectrum disorder (LBSD), including non-demented PD patients, patients with PD dementia (PDD), and patients with dementia with Lewy bodies (DLB), in a semi-structured narrative speech sample in order to characterize impairments of speech fluency and to determine the factors contributing to reduced speech fluency in these patients. Both demented and non-demented PD patients exhibited reduced speech fluency, characterized by reduced overall speech rate and long pauses between sentences. Reduced speech rate in LBSD correlated with measures of between-utterance pauses, executive functioning, and grammatical comprehension. Regression analyses related non-fluent speech, grammatical difficulty, and executive difficulty to atrophy in frontal brain regions. These findings indicate that multiple factors contribute to slowed speech in LBSD, and this is mediated in part by disease in frontal brain regions.

Ash, Sharon; McMillan, Corey; Gross, Rachel G.; Cook, Philip; Gunawardena, Delani; Morgan, Brianna; Boller, Ashley; Siderowf, Andrew; Grossman, Murray

2011-01-01

308

?-Synuclein gene alterations in dementia with Lewy bodies  

PubMed Central

Objective To determine whether mutations in the genes for ?-synuclein or ?-synuclein are responsible for dementia with Lewy bodies (DLB), a disorder closely related to Parkinson disease (PD). Methods The authors ascertained 33 sporadic cases of DLB and 10 kindreds segregating DLB. DNA samples from the 43 index cases were screened for alterations in the genes for ?-synuclein and ?-synuclein, as ?-synuclein alterations cause PD and ?-synuclein may modulate ?-synuclein aggregation and neurotoxicity. Results Two amino acid alterations were identified in unrelated DLB index cases: a valine to methionine substitution at codon 70 (V70M) and a proline to histidine substitution at codon 123 (P123H), both in the ?-synuclein gene. These amino acid substitutions occur at conserved residues in highly conserved regions of the ?-synuclein protein. Screening of at least 660 chromosomes from control subjects matched to the patients’ population groups failed to identify another V70M or P123H allele. Cosegregation analysis of an extended pedigree segregating the P123H ?-synuclein alteration suggested that it is a dominant trait with reduced penetrance or a risk factor polymorphism. Histopathology and immunohistochemistry analysis of index case brain sections revealed widespread Lewy body pathology and ?-synuclein aggregation without evidence of ?-synuclein aggregation. Conclusion Mutations in the ?-synuclein gene may predispose to DLB.

Ohtake, H.; Limprasert, P.; Fan, Y.; Onodera, O.; Kakita, A.; Takahashi, H.; Bonner, L.T.; Tsuang, D.W.; Murray, I.V.J.; Lee, V.M.-Y.; Trojanowski, J.Q.; Ishikawa, A.; Idezuka, J.; Murata, M.; Toda, T.; Bird, T.D.; Leverenz, J.B.; Tsuji, S.; La Spada, A.R.

2006-01-01

309

Modeling non-unity Lewis number effects in premixed flames  

NASA Astrophysics Data System (ADS)

The combustion of hydrogen in Low Swirl Burners (LSB) is considered as an alternative for power production for it is characterized by low emissions and high efficiency. However, lean hydrogen premixed flames are subject to thermo-diffusive instabilities induced by the large diffusivity of hydrogen. The numerical modeling of these flows remain challenging for the transition of small scale instabilities into large scale turbulent structures cannot be modeled by conventional theories. In this work, a model is presented for the simulation of premixed flames with non-unity Lewis number fuels. This model relies on the Levelset/Progress variable approach which was found perfectly suited for the modeling of premixed flames with close to unity Lewis number fuels such as methane. Combined with the solution of an additional transport equation for mixture fraction, this model is formulated and validated in simple 1D laminar premixed flames. The model is found to capture accurately global quantities such as burning velocity and flame thickness as well as mixture fraction fluctuations. Then, this model is applied in Large Eddy Simulation (LES) of a Low Swirl Burner of H2/Air (?=0.4). The simulation shows the formation of a strongly wrinkled flame with local extinction. The results obtained with this new formulation show significant improvement when compared with experimental measurements.

Blanquart, Guillaume; Knudsen, Ed; Pitsch, Heinz

2009-11-01

310

Occurrence of odorant polyfunctional thiols in the Super Alpha Tomahawk hop cultivar. Comparison with the thiol-rich Nelson Sauvin bitter variety.  

PubMed

Tomahawk hop (Humulus lupulus) is a recently developed Super Alpha cultivar (14-18% ?-acids w/w), already widely used by brewers to impart bitterness and a citrus-like aroma to beer. By comparison with two bitter varieties (Nelson Sauvin and Nugget) and two aromatic ones (Cascade and Saaz), the Tomahawk cultivar showed a very particular terpenoid profile, rich in both ?- and ?-selinenes (>600 mg/kg IST equiv in total), methyl geranate (>40 mg/kg IST equiv), and geraniol (>200 mg/kg). Tomahawk also proved to contain a wide variety of odorant polyfunctional thiols. The major ?-sulfanyl acetate, 3-sulfanyl-2-ethylpropyl acetate, newly identified here, was found at similar levels in the famous Sauvignon-like Nelson Sauvin and Tomahawk varieties (15-44 ?g/kg IST equiv). On the other hand, lower levels of total ?-sulfanyl alcohols were measured in Tomahawk, although 3-sulfanylhexan-1-ol was found at a similar level and the 3-sulfanyl-4-methylpentan-1-ol previously claimed to be specific to the Nelson Sauvin variety was also evidenced in the Super Alpha cultivar (9-13 ?g/kg IST equiv). As revealed by boiling and fermentation, Tomahawk hop also contains very interesting bound polyfunctional thiols that should be investigated for better use by brewers. PMID:21740044

Gros, Jacques; Nizet, Sabrina; Collin, Sonia

2011-07-20

311

A Dual Lewis Base Activation Strategy for Enantioselective Carbene-Catalyzed Annulations  

PubMed Central

A dual activation strategy integrating NHC catalysis and a second Lewis base has been developed. NHC-bound homoenolate equivalents derived from ?,?-unsaturated aldehydes combine with transient reactive o-quinione methides in an enatioselective formal [4+3] fashion to access 2-benzoxopinones. The overall approach provides a general blueprint for the integration of carbene catalysis with additional Lewis base activations modes.

Izquierdo, Javier; Orue, Ane; Scheidt, Karl A.

2013-01-01

312

Brain Organochlorines and Lewy Pathology: The Honolulu-Asia Aging Study  

PubMed Central

Background Although organochlorines have been reported more frequently in Parkinson’s disease (PD) brains than controls, the association with brain Lewy pathology is unknown. Honolulu-Asia Aging Study (HAAS) participants, exposed to organochlorines from a variety of sources during mid-life, represent a population well suited to determine the relationship of brain organochlorines with Lewy pathology in decedents from the longitudinal HAAS. Methods Study design included the measurement of 21 organochlorine levels in frozen occipital lobe samples from HAAS decedents. Alpha-synuclein immunostaining performed on 225 brains was used to identify Lewy bodies and Lewy neurites. Results With the potential for spurious associations to appear between Lewy pathology and 17 organochlorine compounds found to be present in at least one brain, initial assessments identified heptachlor epoxide isomer b, methoxychlor, and benzene hexachloride b as being most important. Prevalence of Lewy pathology was 75% (6/8) among brains with any 2 of the 3 compounds, 48.8% (79/162) among those with 1, and 32.7% (18/55) for those with neither (P=0.007 test for trend). While findings persisted after removing cases with PD and dementia with Lewy bodies, and when adjustments were made for age at death, body mass index, pack-years of cigarette smoking, and coffee intake (p=0.013), results were insignificant when correcting for multiple testing. Conclusions While consistent with earlier accounts of an association between organochlorines and clinical PD, associations with Lewy pathology warrant further study.

Ross, G. Webster; Duda, John E.; Abbott, Robert D.; Pellizzari, Edo; Petrovitch, Helen; Miller, Diane B.; O'Callaghan, James P.; Tanner, Caroline M.; Noorigian, Joseph V.; Masaki, Kamal; Launer, Lenore; White, Lon R.

2012-01-01

313

Summary of NASA-Lewis Research Center solar heating and cooling and wind energy programs  

Microsoft Academic Search

NASA is planning to construct and operate a solar heating and cooling system in conjunction with a new office building being constructed at Langley Research Center. The technology support for this project will be provided by a solar energy program underway at NASA's Lewis Research Center. The solar program at Lewis includes: testing of solar collectors with a solar simulator,

R. W. Vernon

1975-01-01

314

COMMON KNOWLEDGE, SALIENCE AND CONVENTION: A RECONSTRUCTION OF DAVID LEWIS' GAME THEORY  

Microsoft Academic Search

David Lewis is widely credited with the first formulation of common knowledge and the first rigorous analysis of convention. However, common knowledge and convention entered mainstream game theory only when they were formulated, later and independently, by other theorists. As a result, some of the most distinctive and valuable features of Lewis game theory have been overlooked. We re-examine this

Robin P. Cubitt; Robert Sugden

2003-01-01

315

Enthalpy Costs of Making and Breaking Bonds: A Game of Generating Molecules with Proper Lewis Structures  

ERIC Educational Resources Information Center

|"Enthalpy Costs" is a simple card game created to assist students in developing proper Lewis structure drawing skills. Score keeping is accomplished by tracking the enthalpy changes associated with bond-making and bond-breaking processes during formation of molecules represented by proper Lewis structures. Playing the game requires the student to…

Bell, Peter T.; Adkins, Alyssa D.; Gamble, Rex J.; Schultz, Linda D.

2009-01-01

316

The Lewis and Clark Expedition. The Constitution Community: Expansion and Reform (1801-1861).  

ERIC Educational Resources Information Center

|In 1803, President Thomas Jefferson guided a piece of foreign diplomacy through the U.S. Senate, the purchase of Louisiana territory from France. Jefferson chose Meriwether Lewis, his personal secretary, who possessed frontiersman skills to explore the territory. Lewis, in turn, solicited the help of William Clark, whose abilities as a draftsman…

Perry, Douglas

317

Sentence Processing in Lewy Body Spectrum Disorder: The Role of Working Memory  

ERIC Educational Resources Information Center

Prior work has related sentence processing to executive deficits in non-demented patients with Parkinson's disease (PD). We extended this investigation to patients with dementia with Lewy bodies (DLB) and PD dementia (PDD) by examining grammatical and working memory components of sentence processing in the full range of patients with Lewy body…

Gross, Rachel G.; McMillan, Corey T.; Chandrasekaran, Keerthi; Dreyfuss, Michael; Ash, Sharon; Avants, Brian; Cook, Philip; Moore, Peachie; Libon, David J.; Siderowf, Andrew; Grossman, Murray

2012-01-01

318

The First Confirmed Case of Down Syndrome with Dementia with Lewy Bodies  

ERIC Educational Resources Information Center

|Dementia with Lewy bodies (DLB) is the second commonest cause of dementia in the general population. Several researches have established an association between Down syndrome (DS) and Alzheimer's disease. Very few studies have however showed such an association between dementia with Lewy bodies and Down syndrome. The occurrence of DLB in persons…

Prasher, V. P.; Airuehia, E.; Carey, M.

2010-01-01

319

“It Is Love”The Lewis Carroll Society as a Fan Community  

Microsoft Academic Search

This article investigates the Lewis Carroll Society of Great Britain, suggesting parallels between popular media fandom and the “high cultural” literary society: the need for community, the obsession with close reading, the pleasures of pilgrimage, and the importance of defending the chosen text from criticism. However, the Lewis Carroll Society diverges from popular fandom in its comparatively greater cultural power,

Will Brooker

2005-01-01

320

Dual roles of sialyl Lewis X oligosaccharides in tumor metastasis and rejection by natural killer cells.  

PubMed Central

Aberrant expression of cell surface carbohydrates such as sialyl Lewis X is associated with tumor formation and metastasis. In order to determine the roles of sialyl Lewis X in tumor metastasis, mouse melanoma B16-F1 cells were stably transfected with alpha1, 3-fucosyltransferase III to express sialyl Lewis X structures. The transfected B16-F1 cells, B16-FTIII, were separated by cell sorting into three different groups based on the expression levels of sialyl Lewis X. When these transfected cells were injected into tail veins of C57BL/6 mice, B16-FTIII.M cells expressing moderate amounts of sialyl Lewis X in poly-N-acetyllactosamines produced large numbers of lung tumor nodules. Surprisingly, B16-FTIII.H cells expressing the highest amount of sialyl Lewis X in shorter N-glycans died in lung blood vessels, producing as few lung nodules as B16-FTIII.N cells which lack sialyl Lewis X. In contrast, B16-FIII.H cells formed more tumors in beige mice and NK cell-depleted C57BL/6 mice than did B16-FTIII.M cells. B16-FTIII.H cells bound to E-selectin better than did B16-FTIII.M cells, but both cells grew at the same rate. These results indicate that excessive expression of sialyl Lewis X in tumor cells leads to rejection by NK cells rather than tumor formation facilitated by attachment to endothelial cells.

Ohyama, C; Tsuboi, S; Fukuda, M

1999-01-01

321

The Triplet State: An Example of G. N. Lewis' Research Style.  

ERIC Educational Resources Information Center

Examines background of ideas against which Lewis's last researches were done, reflecting on his conduct of scientific research. Also analyzes Lewis's unique habit of writing research previews and indicates, through his research memoranda to the author, his intensity of research interest and activity during the last years of his life. (JN)

Kasha, Michael

1984-01-01

322

Sentence Processing in Lewy Body Spectrum Disorder: The Role of Working Memory  

ERIC Educational Resources Information Center

|Prior work has related sentence processing to executive deficits in non-demented patients with Parkinson's disease (PD). We extended this investigation to patients with dementia with Lewy bodies (DLB) and PD dementia (PDD) by examining grammatical and working memory components of sentence processing in the full range of patients with Lewy body…

Gross, Rachel G.; McMillan, Corey T.; Chandrasekaran, Keerthi; Dreyfuss, Michael; Ash, Sharon; Avants, Brian; Cook, Philip; Moore, Peachie; Libon, David J.; Siderowf, Andrew; Grossman, Murray

2012-01-01

323

Gilbert Newton Lewis: His Influence on Physical-Organic Chemists at Berkeley.  

National Technical Information Service (NTIS)

A review is presented of the historical contributions of Gilbert N. Lewis to science and a discussion of the influence of Lewis on the research of the members of the physical-organic staff at Berkeley, including Melvin Calvin, during the twenties, thirtie...

M. Calvin

1982-01-01

324

The Lewis Model and the Diverging Development Paths of Asia and Africa  

Microsoft Academic Search

In this paper we undertake a comparative study of the development paths of Asia and sub- Saharan Africa since the 1960s applying the classical framework of Arthur Lewis's 1954 paper on economic development with unlimited supplies of labour. We will try to show that the classical framework used by Lewis can provide powerful insights into the comparative development trajectories in

Massoud Karshenas

325

The complete mitochondrial genome of the gall-forming fly, Fergusonina taylori Nelson and Yeates (Diptera: Fergusoninidae).  

PubMed

The monogeneric family Fergusoninidae consists of gall-forming flies that, together with Fergusobia (Tylenchida: Neotylenchidae) nematodes, form the only known mutualistic association between insects and nematodes. In this study, the entire 16,000 bp mitochondrial genome of Fergusonina taylori Nelson and Yeates was sequenced. The circular genome contains one encoding region including 27 genes and one non-coding A+T-rich region. The arrangement of the protein-coding, ribosomal RNA (rRNA) and transfer RNA (tRNA) genes was the same as that found in the ancestral insect. Nucleotide composition is highly A+T biased. All of the protein initiation codons are ATN, except for nad1 which begins with TTT. All 22 tRNA anticodons of F. taylori match those observed in Drosophila yakuba, and all form the typical cloverleaf structure except for tRNA-Ser((AGN)) which lacks a dihydrouridine (DHU) arm. Secondary structural features of the rRNA genes of Fergusonina are similar to those proposed for other insects, with minor modifications. The mitochondrial genome of Fergusonina presented here may prove valuable for resolving the sister group to the Fergusoninidae, and expands the available mtDNA data sources for acalyptrates overall. PMID:22165837

Nelson, Leigh A; Cameron, Stephen L; Yeates, David K

2011-10-01

326

Streptococcal cell wall-induced arthritis and adjuvant arthritis in F344----Lewis and in Lewis----F344 bone marrow chimeras  

SciTech Connect

Streptococcal cell wall (SCW)-induced arthritis and adjuvant arthritis (AA) are rat models for chronic, erosive polyarthritis. Both models can be induced in susceptible Lewis rats, whereas F344 rats are resistant. In AA as well as in SCW arthritis, antigen-specific T lymphocytes have been demonstrated to be crucial for chronic disease. In this communication the authors describe their studies to probe the cellular mechanism responsible for the difference in susceptibility of Lewis and F344, using bone marrow chimeras. By transplanting bone marrow cells from F344 into lethally irradiated Lewis recipients, Lewis rats were rendered resistant to SCW arthritis induction. F344 rats reconstituted with Lewis bone marrow, i.e., Lewis----F344 chimeras, develop an arthritis upon SCW injection. For AA comparable results were obtained. These data suggest that both resistance and susceptibility to bacterium-induced chronic arthritis are mediated by hemopoietic/immune cells and that the recipiental environment does not influence the susceptibility to chronic joint inflammation.

van Bruggen, M.C.; van den Broek, M.F.; van den Berg, W.B. (University Hospital Nijmegen, (Netherlands))

1991-09-01

327

Element analysis of Lewy and adrenal bodies in Parkinson's disease by electron probe microanalysis.  

PubMed

Two possible interpretations of the origin of Lewy bodies and adrenal bodies found in Parkinson's disease are now under discussion: a disorder of (1) catecholamine metabolism or (2) sphingomyelin lipidosis. From the electron probe microanalysis of Lewy bodies and adrenal bodies, we find that the Lewy body contains sulfur, calcium, and phosphorus, and the adrenal body also contains these three elements. Furthermore, a positive correlation was obtained between the X-ray intensity of the sulfur and the diameter of adrenal body. For Lewy bodies, this correlation was not obtained. The results suggest that a common mechanism may exist for the production of Lewy and adrenal bodies, although they differ somewhat in their accumulation of sulfur. It is considered that both structures may originate, in part, from degenerated protein containing sulfur. PMID:6845984

Kimula, Y; Utsuyama, M; Yoshimura, M; Tomonaga, M

1983-01-01

328

Functional group chemistry at intramolecular frustrated Lewis pairs: substituent exchange at the Lewis acid site with 9-BBN.  

PubMed

The vicinal frustrated P/B Lewis pair (FLP) Mes(2)PCH(2)CH(2)B(C(6)F(5))(2) reacts with 9-borabicyclo[3.3.1]nonane (9-BBN) by C(6)F(5)vs. H exchange at boron to give the new [B]-H functionalized FLP Mes(2)PCH(2)CH(2)B(H)(C(6)F(5)) (4) and 9-C(6)F(5)-BBN. The latter was characterized as an isonitrile adduct by X-ray diffraction. The new FLP 4 forms an adduct with pyridine and it undergoes clean hydroboration reactions with 1-pentyne or added styrene or dimesitylvinylphosphane. The products formed stable adducts with pyridine; two such examples were also characterized by X-ray crystal structure analysis. A similar alkyl vs. hydrogen exchange was observed upon treatment of an Al/N based Lewis pair, iBu(2)Al-(Me(3)Si)C=C(H)-N(CH(2)CH(2))(2)NMe (14), with 9-BBN. PMID:23014979

Erdmann, Markus; Rösener, Christian; Holtrichter-Rößmann, Thorsten; Daniliuc, Constantin G; Fröhlich, Roland; Uhl, Werner; Würthwein, Ernst-Ulrich; Kehr, Gerald; Erker, Gerhard

2013-01-21

329

Psychiatric Morbidity in Dementia With Lewy Bodies: A Prospective Clinical and Neuropathological Comparative Study With Alzheimer's Disease  

Microsoft Academic Search

Objective: The literature reports considerable variation in the rates of psychiatric mor- bidity for patients with dementia with Lewy bodies. The authors intended to clarify the fre- quency of psychiatric morbidity in dementia with Lewy bodies and how it differs from prob- able Alzheimer's disease. Method: The study incorporated two groups—a clinical case register cohort (98 with dementia with Lewy

Clive Ballard; M. R. C. Psych; Clive Holmes; Ian McKeith; F. R. C. Psych; David Neill; John O'Brien; Nigel Cairns; Peter Lantos; Elaine Perry; Paul Ince; Robert Perry

1999-01-01

330

Tarnished silver anniversary. Reflections on Humanae Vitae. Galileo all over again.  

PubMed

In 1964, an American Roman Catholic couple active in the Christian Family Movement was invited by the Pope to participate in a Special Study Group on Population and Birth Control. In March, 1965, the couple arrived in Rome for the first meeting of an enlarged commission on the topic. Other commission members were theologians, philosophers, demographers, psychologists, zoologists, economists, bishops, cardinals, and physicians who operated rhythm method clinics. Participants were asked not to speak with the press, and the couple complied except for mentioning that they were housed in separate quarters. This situation was changed for subsequent meetings. The couple's job was to prepare a questionnaire for married couples asking their opinion of the rhythm method. This questionnaire was formatted by the University of Notre Dame sociology department and sent to thousands of couples around the world. The replies were heart-rending as people related their difficulties with the rhythm method and the burdens they faced rearing large families. The letters were bound and given to the theologians who met separately and then reported that 90% of them felt that birth control was not intrinsically evil. The entire commission reviewed the document prepared by the theologians, and 90% agreed with it. This document was presented to the Pope. The couple heard nothing further about the work of the commission until 1968 when a reporter called them in the middle of the night asking their opinion of the newly-released Humanae Vitae. Now 25 years later, the wife still feels betrayed by the Church. She feels that the encyclical has been responsible for a credibility gap between Church leaders and laypeople. She affirms her right to belong to the Church and longs for the Church to become honest in its teachings. She notes that it took the Church centuries to acknowledge the work of Galileo and hopes the Church will soon adopt an honest approach to family planning. PMID:12178860

Crowley, P

1994-01-01

331

IR-spectroscopic study of lewis acid centers on polyzirconiummethylsiloxanes  

NASA Astrophysics Data System (ADS)

Acid centers on the surface of polyzirconiummethylsiloxanes (PZMS) containing 5 and 10% ZrO2 were studied by diffuse-reflectance IR-spectroscopy. Deuterated acetonitrile adsorbed at room temperature at a 96 torr saturated vapor pressure was used as a probe-molecule for acid centers. It was shown that zirconium ions were not built into the matrix but were situated predominantly on the surface of the siliconoxygen framework of silica gels. The introduction of zirconium ions into the polymethylsiloxane matrix at the stage of sol formation caused the appearance of Lewis acid centers (coordinatively unsaturated zirconium ions) on the surface of PZMS along with centers of the physical adsorption of CD3CN.

Kustov, L. M.; Tkachenko, O. P.; Bondar', L. A.

2010-07-01

332

Renal failure in dementia with lewy bodies presenting as catatonia.  

PubMed

Catatonia, originally described by Karl Kahlbaum in 1874, may be regarded as a set of clinical features found in a subtype of schizophrenia, but the syndrome may also stem from organic causes including vascular parkinsonism, brain masses, globus pallidus lesions, metabolic derangements, and pharmacologic agents, especially first generation antipsychotics. Catatonia may include paratonia, waxy flexibility (cerea flexibilitas), stupor, mutism, echolalia, and catalepsy (abnormal posturing). A case of catatonia as a result of acute renal failure in a patient with dementia with Lewy bodies is described. This patient recovered after intravenous fluid administration and reinstitution of the atypical dopamine receptor blocking agent quetiapine, but benzodiazepines and amantadine are additional possible treatments. Recognition of organic causes of catatonia leads to timely treatment and resolution of the syndrome. PMID:23466522

Fekete, Robert

2013-01-18

333

Human Intestinal M Cells Display the Sialyl Lewis A Antigen  

PubMed Central

The biochemical features that distinguish human M cells from other intestinal epithelial cell types are important for understanding microbial pathogenesis and for targeting vaccines to the mucosal immune system. We applied a large panel of carbohydrate-specific monoclonal antibodies and lectins to Peyer’s patch and cecum biopsy specimens from three normal individuals and a patient with inflammatory bowel disease. The results show that human M-cell glycosylation patterns are distinct from those of other species examined and that human M cells preferentially display the sialyl Lewis A antigen. This carbohydrate epitope is also present in a small subpopulation of enterocytes in the follicle-associated epithelium and in goblet cell mucins.

Giannasca, Paul J.; Giannasca, Karen T.; Leichtner, Alan M.; Neutra, Marian R.

1999-01-01

334

Can we clinically diagnose dementia with Lewy bodies yet?  

PubMed Central

Dementia with Lewy Bodies (DLB) was initially identified and confirmed primarily by pathology, but is soon to be incorporated into the Diagnostic and Statistical Manual criteria as a clinical disease entity. Despite these advances over more than 20 years, current data suggest that the sensitivity of accurate clinical diagnosis of DLB is still very low, although there is mounting evidence that supportive features may increase diagnostic accuracy. Although DLB remains easy to identify pathologically with different cellular pathologies differentiating it from other dementia syndromes, pathological identification using only Lewy body pathology has been shown to be inaccurate due to overlap with patients without dementia symptoms. A number of studies now suggest that a combination of cellular pathologies, which include ?-synuclein and ?-amyloid deposition as well as dopamine denervation, assist with differentiating this dementia syndrome from others. The clinical and pathological overlap with the tauopathy of Alzheimer’s disease still remains to be clarified. To determine more robust and independent clinicopathological correlates from Alzheimer’s disease, longitudinal prospective studies, using specific clinical batteries on dementia patients reaching the proposed criteria for DLB, with post-mortem assessment of the multiple pathologies associated with dementia, are required. Identifying genetic causes for DLB is another approach to investigate the pathogenesis of DLB. However this approach has been hindered to date by difficulties with identifying DLB clinically. The use of novel techniques is likely to advance knowledge on the pathogenesis of DLB and assist with redefining clinical and pathologic diagnostic criteria. To achieve the goal of more accurate clinical diagnosis of DLB, breakthroughs are necessary on the pathogenesis of DLB.

2013-01-01

335

Alcohol consumption, Lewis phenotypes, and risk of ischemic heart disease  

SciTech Connect

The authors have previously found an increased risk of ischemic heart disease (IHD) in men with the Lewis phenotype Le(a[minus]b[minus]) and suggested that the Lewis blood group has a close genetic relation with insulin resistance. The authors have investigated whether any conventional risk factors explain the increased risk in Le(a[minus]b[minus]) men. 3,383 men aged 53-75 years were examined in 1985-86, and morbidity and mortality during the next 4 years were recorded. At baseline, the authors excluded 343 men with a history of myocardial infarction, angina pectoris, intermittent claudication, or stroke. The potential risk factors examined were alcohol consumption, physical activity, tobacco smoking, serum cotinine, serum lipids, body-mass index, blood pressure, prevalence of hypertension and non-insulin-dependent diabetes mellitus, and social class. In 280 (9.6%) men with Le(a[minus]b[minus]), alcohol was the only risk factor significantly associated with risk of IHD. There was a significant inverse dose-effect relation between alcohol consumption and risk; trend tests, with adjustment for age, were significant for fatal IHD (p=0.02), all IHD (p=0.03), and all causes of death (p=0.02). In 2649 (90.4%) men with other phenotypes, there was a limited negative association with alcohol consumption. In Le(a[minus]b[minus]) men, a group genetically at high risk of IHD, alcohol consumption seems to be especially protective. The authors suggest that alcohol consumption may modify insulin resistance in Le(a[minus]b[minus]) men.

Hein, H.O.; Suadicani, P.; Gyntelberg, F. (Rigshospitalet State Univ. Hospital, Copenhagen (Denmark). Epidemiological Research Unit); Sorenson, H. (Rigshospitalet State Univ. Hospital, Copenhagen (Denmark). Dept. of Chemical Immunology); Hein, H.O. (Univ. of Copenhagen (Denmark). Dept. of Internal Medicine)

1993-02-13

336

Quantitative phase-field modeling of solidification at high Lewis number.  

PubMed

A phase-field model of nonisothermal solidification in dilute binary alloys is used to study the variation of growth velocity, dendrite tip radius, and radius selection parameter as a function of Lewis number at fixed undercooling. By the application of advanced numerical techniques, we have been able to extend the analysis to Lewis numbers of order 10 000, which are realistic for metals. A large variation in the radius selection parameter is found as the Lewis number is increased from 1 to 10 000. PMID:19391885

Rosam, J; Jimack, P K; Mullis, A M

2009-03-12

337

Localization of MAP1-LC3 in vulnerable neurons and Lewy bodies in brains of patients with dementia with Lewy bodies.  

PubMed

There is emerging evidence implicating a role for the autophagy-lysosome pathway in the pathogenesis of Lewy body disease. We investigated potential neuropathologic and biochemical alterations of autophagy-lysosome pathway-related proteins in the brains of patients with dementia with Lewy bodies (DLB), Alzheimer disease (AD), and control subjects using antibodies against Ras-related protein Rab-7B (Rab7B), lysosomal-associated membrane protein 2 (LAMP2), and microtubule-associated protein 1A/1B light chain 3 (LC3). In DLB, but not in control brains, there were large Rab7B-immunoreactive endosomal granules. LC3 immunoreactivity was increased in vulnerable areas of DLB brains relative to that in control brains; computerized cell counting analysis revealed that LC3 levels were greater in the entorhinal cortex and amygdala of DLB brains than in controls. Rab7B levels were increased, and LAMP2 levels were decreased in the entorhinal cortex of DLB brains. In contrast, only a decrease in LAMP2 levels versus controls was found in AD brains. LC3 widely colocalized with several types of Lewy pathology; LAMP2 localized to the periphery or outside of brainstem-type Lewy bodies; Rab7B did not colocalize with Lewy pathology. Immunoblot analysis demonstrated specific accumulation of the autophagosomal LC3-II isoform in detergent-insoluble fractions from DLB brains. These results support apotential role for the autophagy-lysosome pathway in the pathogenesis of DLB. PMID:21412173

Higashi, Shinji; Moore, Darren J; Minegishi, Michiko; Kasanuki, Koji; Fujishiro, Hiroshige; Kabuta, Tomohiro; Togo, Takashi; Katsuse, Omi; Uchikado, Hirotake; Furukawa, Yoshiko; Hino, Hiroaki; Kosaka, Kenji; Sato, Kiyoshi; Arai, Heii; Wada, Keiji; Iseki, Eizo

2011-04-01

338

Generalisability of the results of the Dutch-Belgian randomised controlled lung cancer CT screening trial (NELSON): does self-selection play a role?  

PubMed

The degree of self-selection in the Dutch-Belgian randomised controlled lung cancer screening trial (NELSON) was determined to assess the generalisability of the study results. 335,441 (mainly) men born in 1928-1953 received a questionnaire. Of the respondents (32%), eligible subjects were invited to participate (19%). Fifty-five percent gave informed consent and was randomised. Background characteristics were compared between male respondents on the first questionnaire (n = 92,802), eligible subjects among them (n = 18,570) and those randomised (n = 10,627) and Statistics Netherlands 2002-2005 (SN) (n = 5289) or GLOBE study-data (Dutch cohort) (n = 696). Initial respondents were less likely to be highly educated (OR(adj) = 0.84; 95% CI: 0.74-0.96) and comprised of significantly less current smokers (OR(adj) = 0.65; 95% CI: 0.61-0.69) compared to the general population. These current smokers smoked more heavily (OR(adj) = 1.23; 95% CI: 1.10-1.37), but for a shorter time-period (respondents: 31, SN: 42 years, p < 0.001). Age, general health, BMI, alcohol use and cancer prevalence were comparable. The randomised population was younger (Age 50-65) (randomised subjects: 85.3%, SN: 72% (p < 0.01)) comprised of more heavy current smokers (OR = 2.08; 95% CI: 1.75-2.44), that smoked for a shorter period of time (randomised subjects: 37, SN_selection: 42 years (p < 0.001)). Both the respondents (32%) of the first questionnaire as well as the randomised population of the NELSON trial appeared to differ slightly on smoking characteristics, but the differences were limited and probably balance each other. Results of the NELSON trial will be roughly applicable to the Dutch and probably other populations that fulfil our selection criteria. PMID:22459203

van der Aalst, C M; van Iersel, C A; van Klaveren, R J; Frenken, F J M; Fracheboud, J; Otto, S J; de Jong, P A; Oudkerk, M; de Koning, H J

2012-03-27

339

Organo-Lewis acid as cocatalyst for cationic homogenous metallocene Ziegler-Natta olefin polymerizations  

DOEpatents

The synthesis of the organo-Lewis acid perfluorobiphenylborane (PBB) and the activation of metallocenes for the formation of a variety of highly active homogeneous Ziegler-Natta metallocene olefin polymerization, copolymerization and ring-opening polymerization catalysts is described.

Marks, Tobin J. (Evanston, IL); Chen, You-Xian (Chicago, IL)

2000-01-01

340

75 FR 11151 - Lewis County Development Corporation; Notice of Preliminary Permit Application Accepted for...  

Federal Register 2010, 2011, 2012, 2013

...Lewis County Development Corporation, P.O. Box 704, Lyons Falls, NY 13368, (315) 348-4066. FERC Contact: Michael Watts, (202) 502-6123. Deadline for filing comments, motions to intervene, competing applications (without...

2010-03-10

341

A Surprising Mechanistic "Switch" in Lewis Acid Activation: A Bifunctional, Asymmetric Approach to ?-Hydroxy Acid Derivatives  

PubMed Central

We report a detailed synthetic and mechanistic study of an unusual bifunctional, sequential hetero-Diels–Alder/ring-opening reaction in which chiral, metal complexed ketene enolates react with o-quinones to afford highly enantioenriched, ?-hydroxylated carbonyl derivatives in excellent yield. A number of Lewis acids were screened in tandem with cinchona alkaloid derivatives; surprisingly, trans-(Ph3P)2PdCl2 was found to afford the most dramatic increase in yield and rate of reaction. A series of Lewis acid binding motifs were explored through molecular modeling, as well as IR, UV and NMR spectroscopy. Our observations document a fundamental mechanistic “switch” – namely the formation of a tandem Lewis base/Lewis acid activated metal enolate in preference to a metal-coordinated quinone species (as observed in other reactions of o-quinone derivatives). This new method was applied to the syntheses of several pharmaceutical targets, each of which was obtained in high yield and enantioselectivity.

Abraham, Ciby J.; Paull, Daniel H.; Bekele, Tefsit; Scerba, Michael T.; Dudding, Travis; Lectka, Thomas

2009-01-01

342

Research and Technology, Annual Report, 1986 (National Aeronautics and Space Administration, Lewis Research Center).  

National Technical Information Service (NTIS)

The research and technology accomplishments of the NASA Lewis Research Center are summarized for the fiscal year 1986, the 45th anniversary year of the Center. Five major sections are presented covering: aeronautics, aerospace technology, space communicat...

1986-01-01

343

Structure-Property Relationships in Solid AlF3 Lewis Acids  

SciTech Connect

Understanding the structural cause of the high Lewis acidity in the novel solid Lewis acid AlF3 is of crucial importance to tailor this important material property to the specific needs of potential applications. Based on Al and F K-edge XAS studies, we are able to correlate high Lewis acidity with geometric distortions of the [AlF6] building blocks of AlF3. These distortions are induced by the presence of i-OPr ligands in the AlF3-x(i-OPr)x precursor material and can only be preserved by the application of a mild fluorinating agent like CCl2F2. High Lewis acidity is not caused by electronic modification of the aluminium atom, but by the better exposure of reactants to the acid site in the high surface area materials.

Weiher, Norbert; Makarowicz, Anna; Beesley, Angela M. [Molecular Materials Centre, School of Chemical Engineering and Analytical Science, Sackville Street, PO Box 88, Manchester, M60 1QD (United Kingdom); Kemnitz, Erhard [Institute of Chemistry, Humboldt University Berlin, Brook-Taylor Str. 2. 12489 Berlin (Germany); Schroeder, Sven L. M. [Molecular Materials Centre, School of Chemical Engineering and Analytical Science, Sackville Street, PO Box 88, Manchester, M60 1QD (United Kingdom); Molecular Materials Centre, School of Chemistry, Sackville Street, PO Box 88, Manchester, M60 1QD (United Kingdom)

2007-02-02

344

Redox and Lewis acid-base activities through an electronegativity-hardness landscape diagram.  

PubMed

Chemistry is the science of bond making and bond breaking which requires redistribution of electron density among the reactant partners. Accordingly acid-base and redox reactions form cardinal components in all branches of chemistry, e.g., inorganic, organic, physical or biochemistry. That is the reason it forms an integral part of the undergraduate curriculum all throughout the globe. In an electronegativity (?)- hardness (?) landscape diagram the diagonal ??=?? line separates reducing agents from oxidizing agents as well as Lewis acids from Lewis bases. While electronegativity is related to the degree of electron transfer between two reactants, hardness is related to the resistance to that process. Accordingly the electronegativities of oxidizing agents/Lewis acids are generally greater than the corresponding hardness values and the reverse is true for reducing agents/Lewis bases. Electrophiles and nucleophiles are also expected to follow similar trends. PMID:24043544

Das, Ranjita; Vigneresse, Jean-Louis; Chattaraj, Pratim Kumar

2013-09-17

345

Compendium of Utility Software Available on the Lewis TSS/370 Computer.  

National Technical Information Service (NTIS)

Descriptions of software developed for use on the Lewis TSS/370 System are presented. The software items were developed to allow the TSS/370 to assist in the accomplishment of management and administrative tasks such as status reporting, preparing present...

J. J. Pelouch

1982-01-01

346

Effects of Lewis Number on Scalar Dissipation Transport and Its Modeling in Turbulent Premixed Combustion  

Microsoft Academic Search

The effects of Lewis number (Le) on scalar dissipation rate transport of the reaction progress variable have been studied using 3-dimensional DNS data of freely propagating turbulent premixed flames with global Lewis number ranging from 0.34 to 1.2. It has been found that the effects of dilatation rate become increasingly strong with decreasing Le, and is particularly strong for the

N. Chakraborty; N. Swaminathan

2010-01-01

347

Mild alpha-halogenation reactions of 1,3-dicarbonyl compounds catalyzed by Lewis acids.  

PubMed

Lewis acid Mg(ClO4)2, combined with NBS, in CH3CN or EtOAc provided mild and fast bromination of 1,3-dicarbonyl compounds. In particular, this protocol could be applied to the alpha-monobromination of alpha-unsubstituted beta-keto esters. Similar Lewis acid catalysis was also extended to the alpha-chlorination and iodination of 1,3-dicarbonyl compounds with NCS and NIS, respectively. PMID:12375975

Yang, Dan; Yan, Yi-Long; Lui, Bob

2002-10-18

348

Thioarsenides: A case for long-range Lewis acid-base-directed van der Waals interactions  

SciTech Connect

Electron density distributions, bond paths, Laplacian and local energy density properties have been calculated for a number of As4Sn (n = 3,4,5) thioarsenide molecular crystals. On the basis of the distributions, the intramolecular As-S and As-As interactions classify as shared bonded interactions and the intermolecular As-S, As-As and S-S interactions classify as closed-shell van der Waals bonded interactions. The bulk of the intermolecular As-S bond paths link regions of locally concentrated electron density (Lewis base regions) with aligned regions of locally depleted electron density (Lewis acid regions) on adjacent molecules. The paths are comparable with intermolecular paths reported for several other molecular crystals that link aligned Lewis base and acid regions in a key-lock fashion, interactions that classified as long range Lewis acid-base directed van der Waals interactions. As the bulk of the intermolecular As-S bond paths (~70%) link Lewis acid-base regions on adjacent molecules, it appears that molecules adopt an arrangement that maximizes the number of As-S Lewis acid-base intermolecular bonded interactions. The maximization of the number of Lewis acid-base interactions appears to be connected with the close-packed array adopted by molecules: distorted cubic close-packed arrays are adopted for alacránite, pararealgar, uzonite, realgar and ?-AsS and the distorted hexagonal close-packed arrays adopted by ?- and ?-dimorphite. A growth mechanism is proposed for thioarsenide molecular crystals from aqueous species that maximizes the number of long range Lewis acid-base vdW As-S bonded interactions with the resulting directed bond paths structuralizing the molecules as a molecular crystal.

Gibbs, Gerald V.; Wallace, Adam F.; Downs, R. T.; Ross, Nancy L.; Cox, David F.; Rosso, Kevin M.

2011-04-01

349

Voluntary wheel running modulates glutamate receptor subunit gene expression and stress hormone release in Lewis rats  

Microsoft Academic Search

Lewis rats that are known to be addiction-prone, develop compulsive running if they have access to running wheels. The present experiments were aimed 1) to evaluate the activation of stress systems following chronic and acute voluntary wheel running in Lewis rats by measurement of hormone release and gene expression of neuropeptides related to hypothalamic-pituitary-adrenocortical (HPA) axis activity and 2) to

A. Makatsori; R. Duncko; M. Schwendt; F. Moncek; B. B. Johansson; D. Jezova

2003-01-01

350

Lewy body-related a-synucleinopathy in the aged human brain  

Microsoft Academic Search

Summary. To clarify the significance of Lewy body (LB)-related ?-synucleinopathy in aging and various neurodegenerative disorders, its incidence and topographic pattern were examined in 260 brains of elderly patients, including 116 autopsy-proven cases of Alzheimer disease (AD), 71 cases of clinically and autopsy-proven Parkinson disease (PD), 38 of dementia with Lewy bodies (DLB), 8 patients with progressive supranuclear palsy (PSP),

K. A. Jellinger

2004-01-01

351

Differences in Nicotine-Induced Dopamine Release and Nicotine Pharmacokinetics Between Lewis and Fischer 344 Rats  

Microsoft Academic Search

Studies have shown a greater preference for the self-administration of drugs such as nicotine and cocaine in the Lewis rat strain than in the Fischer 344 strain. We examined some factors that could contribute to such a difference. The baseline level of extracellular dopamine in nucleus accumbens shell was about 3-times higher in Fischer rats than in Lewis rats (3.18

I. Sziraki; M. N. Lipovac; A. Hashim; H. Sershen; D. Allen; T. Cooper; P. Czobor; A. Lajtha

2001-01-01

352

Nelson Diversity Surveys  

NSDL National Science Digital Library

This site provides results of and information about our diversity surveys, which determined demographics of tenured / tenure track faculty at pertinent departments of the "top 50" universities, ranked by NSF (National Science Foundation) according to research expenditures in that discipline. These are the first published data, disaggregated by gender, by race, and by rank, on faculty at the top 50 research universities in each of 14 science and engineering disciplines. These surveys were conducted under the auspices of the University of Oklahoma and the Diversity in Science Association. Data were collected by surveying department chairs; each department chair provided faculty data, disaggregated by gender, by race/ethnicity, and by rank. Fifty universities (chairs) were surveyed in each of the 14 disciplines studied. Target Audience: 2-4 Year College Faculty/Administrators, Engineers, Industry Personnel, Government Personnel, Scientists,Technicians, General Public

2009-11-23

353

Gelsolin co-occurs with Lewy bodies in vivo and accelerates ?-synuclein aggregation in vitro.  

PubMed

Deposition of fibrillar ?-synuclein as Lewy bodies is the neuropathological hallmark of Parkinson's disease (PD) and dementia with Lewy bodies (DLB). Apart from ?-synuclein, these intraneuronal inclusions contain over 250 different proteins. The actin binding protein gelsolin, has previously been suggested to be part of the Lewy body, but its potential role in ?-synuclein aggregation remains unknown. Here, we studied the association between gelsolin and ?-synuclein in brain tissue from PD and DLB patients as well as in a cell model for ?-synuclein aggregation. Moreover, the potential effect of gelsolin on ?-synuclein fibrillization was also investigated. Our data demonstrate that gelsolin co-occured with ?-synuclein in Lewy bodies from affected human brain as well as with Lewy body-like inclusions in ?-synuclein over expressing cells. Furthermore, in the presence of calcium chloride, gelsolin was found to enhance the aggregation rate of ?-synuclein in vitro. Moreover, no apparent structural differences could be observed between fibrils formed in the presence or absence of gelsolin. Further studies on gelsolin and other Lewy body associated proteins are warranted to learn more about their potential role in the ?-synuclein aggregation process. PMID:21798243

Welander, Hedvig; Bontha, Sai Vineela; Näsström, Thomas; Karlsson, Mikael; Nikolajeff, Fredrik; Danzer, Karin; Kostka, Marcus; Kalimo, Hannu; Lannfelt, Lars; Ingelsson, Martin; Bergström, Joakim

2011-07-21

354

Rapid eye movement sleep behavior disorder and subtypes in autopsy-confirmed dementia with Lewy bodies.  

PubMed

The purpose of this study was to determine whether dementia with Lewy bodies with and without probable rapid eye movement sleep behavior disorder differ clinically or pathologically. Patients with dementia with Lewy bodies (DLB) with probable rapid eye movement sleep behavior sleep disorder (n = 71) were compared with those without it (n = 19) on demographics, clinical variables (core features of dementia with Lewy bodies, dementia duration, rate of cognitive/motor changes), and pathologic indices (Lewy body distribution, neuritic plaque score, Braak neurofibrillary tangle stage). Individuals with probable rapid eye movement sleep behavior disorder were predominantly male (82% vs 47%) and had a shorter duration of dementia (mean, 8 vs 10 years), earlier onset of parkinsonism (mean, 2 vs 5 years), and earlier onset of visual hallucinations (mean, 3 vs 6 years). These patients also had a lower Braak neurofibrillary tangle stage (stage IV vs stage VI) and lower neuritic plaque scores (18% vs 85% frequency), but no difference in Lewy body distribution. When probable rapid eye movement sleep behavior disorder developed early (at or before dementia onset), the onset of parkinsonism and hallucinations was earlier and Braak neurofibrillary tangle stage was lower compared with those who developed the sleep disorder after dementia onset. Women with autopsy-confirmed DLB without a history of dream enactment behavior during sleep had a later onset of hallucinations and parkinsonism and a higher Braak NFT stage. Probable rapid eye movement sleep behavior disorder is associated with distinct clinical and pathologic characteristics of dementia with Lewy bodies. PMID:22038951

Dugger, Brittany N; Boeve, Bradley F; Murray, Melissa E; Parisi, Joseph E; Fujishiro, Hiroshige; Dickson, Dennis W; Ferman, Tanis J

2011-10-28

355

Functional evaluation of cerebral cortex in dementia with Lewy bodies.  

PubMed

Neurochemical investigations have demonstrated central cholinergic dysfunction in patients with dementia with Lewy bodies (DLB). Central cholinergic circuits of the human brain can be tested non-invasively by coupling peripheral nerve stimulation with transcranial magnetic stimulation of the contralateral motor cortex. This test, named short latency afferent inhibition has been shown in healthy subjects to be sensitive to the blockage of muscarinic acetylcholine receptors and it is impaired in patients with Alzheimer disease (AD), a cholinergic form of dementia, while it is normal in non-cholinergic forms of dementia such as fronto-temporal dementia. We evaluated short latency afferent inhibition in a group of patients with DLB and compared the data with that from a group of AD patients and a control group of age-matched healthy individuals. Short latency afferent inhibition was significantly reduced in DLB and AD patients. The findings suggest that this method can be used as a non-invasive test for the assessment of cholinergic pathways in patients with dementia and may represent a useful additional tool for discriminating between cholinergic and non-cholinergic forms of dementia. PMID:17570682

Di Lazzaro, Vincenzo; Pilato, Fabio; Dileone, Michele; Saturno, Eleonora; Profice, Paolo; Marra, Camillo; Daniele, Antonio; Ranieri, Federico; Quaranta, Davide; Gainotti, Guido; Tonali, Pietro A

2007-05-10

356

Helicobacter pylori expresses a complex surface carbohydrate, Lewis X.  

PubMed

Monoclonal antibodies (MAbs) specific for Lewis X (Lex) reacted with whole cells of Helicobacter pylori NCTC11637, UA799, UA802, UA825, UA861, UA1182, and UA1206 in immunoelectron microscopy and enzyme-linked immunosorbent assay (ELISA) experiments. These MAbs have documented specificity to Lex, whereas MAbs for Lea and Leb were negative in both immunoelectron microscopy and ELISA. H. pylori coccoid forms also reacted with the MAbs, whereas the flagellum lacking the sheath showed no reactivity. The Lex structures were associated with membrane fractions in the ELISA experiments, and silver-stained sodium dodecyl sulfate-polyacrylamide gels confirmed the presence of lipopolysaccharides which reacted with the MAbs in immunoblots. Serum from an H. pylori-infected individual contained immunoglobulins which blocked the binding of the Lex MAbs, indicating that part of the host immune response to H. pylori is to the Lex structure. The ability of this gastric pathogen to mimic an oncofetal antigen (self) could explain the down regulation of anti-H. pylori T-cell response seen in H. pylori-infected individuals. PMID:7591106

Sherburne, R; Taylor, D E

1995-12-01

357

Fort Lewis electric energy baseline and efficiency resource assessment  

SciTech Connect

In support of the US DOE Federal Energy Management Program, the Pacific Northwest Laboratory is developing a fuel-neutral approach for identifying, evaluating, and acquiring all cost-effective energy projects at federal installations. Fort Lewis, a US Army installation near Tacoma, Washington, was selected as the pilot site for developing this approach. This site was chosen in conjunction with the interests of the Bonneville Power Administration to develop programs for its federal sector customers and the Army Forces Command to develop an in-house program to upgrade the energy efficiency of its installations. This report documents the electricity assessment portion of the approach, providing an estimate of the electricity use baseline and efficiency improvement potential for major sectors and end uses at the Fort. Although the assessment did not identify all possible efficiency improvement opportunities, it is estimated that electricity use can be reduced by at least 20% cost-effectively at the $0.045/kWh marginal cost of electricity in the Pacific Northwest. 12 refs., 3 figs., 7 tabs.

Secrest, T.J.; Currie, J.W.; DeSteese, J.G.; Dirks, J.A.; Marseille, T.J.; Parker, G.B.; Richman, E.E.; Shankle, S.A.

1991-10-01

358

Fort Lewis electric energy baseline and efficiency resource assessment  

SciTech Connect

The mission of the US Department of Energy (DOE) Federal Energy Management Program (FEMP) is to lead the improvement of energy efficiency and fuel flexibility within the federal sector. Through Pacific Northwest Laboratory, FEMP is developing a fuel-neutral approach for identifying, evaluating, and acquiring all cost-effective energy projects at federal installations. In this report, we describe PNL's assessment of the electric energy efficiency resource potential at Fort Lewis (near Tacoma, WA). Through this assessment, we developed an estimate of the electricity use baseline and efficiency improvement potential for major sectors and end uses at the Fort. Developing the baseline was essential to segment the end uses that are targets for broad-based efficiency improvement programs and to provide TPU with the basis for its proposal to Bonneville. An estimate of the efficiency resource is presented to reflect the available quantity of resource for three electricity price ranges. The baseline and efficiency resource estimates did not identify all possible areas of opportunity, but instead identified the majority of the resource; areas of additional opportunity are noted, to encourage further effort. 2 figs., 2 tabs.

Secrest, T.J.; Currie, J.W.; DeSteese, J.G.; Dirks, J.A.; Marseille, T.J.; Parker, G.B.; Richman, E.E.; Shankle, S.A.

1991-10-01

359

Phosphinimine-borane combinations in frustrated Lewis pair chemistry.  

PubMed

The phosphinimines Ph(3)PNR (R = Ph 1, C(6)F(5) 2, tBu 3) are combined with B(C(6)F(5))(3) in an effort to explore the frustrated Lewis pair (FLP) chemistry. While compound 1 is shown to form an adduct with the borane, compounds 2 and 3 exhibit no apparent interaction. Nonetheless exposure of each of the three combinations to H(2) resulted in the formation of the corresponding salts [Ph(3)PN(H)R][HB(C(6)F(5))(3)] (R = Ph 5, C(6)F(5) 6, tBu 7). Reaction of 1 or 2 with B(C(6)F(5))(3) and carbon dioxide afforded Ph(3)PN(R)COOB(C(6)F(5))(3) (R = Ph 8, C(6)F(5) 9) while the corresponding reaction with 3 gave rise only to the tBuNCO and (Ph(3)PO)B(C(6)F(5))(3). Reactions of 1-3 and B(C(6)F(5))(3) with PhC?CH proceeds to give either deprotonation or addition affording products of the form [Ph(3)PN(H)R][PhC?CB(C(6)F(5))(3)] or (Ph(3)PNR)(Ph)C=CH(B(C(6)F(5))(3)). The factors governing the nature of the dominant products are considered. PMID:22584752

Jiang, Chunfang; Stephan, Douglas W

2013-01-21

360

Multimodality Imaging Characteristics of Dementia with Lewy Bodies  

PubMed Central

Dementia with Lewy bodies (DLB) is the second most common cause of neurodegenerative dementia after Alzheimer's disease (AD). Our objective was to determine whether the 11C–Pittsburgh Compound-B (PiB) retention and regional hypometabolism on PET and regional cortical atrophy on MRI are complementary in characterizing patients with DLB and differentiating them from AD. We studied age, gender and education matched patients with a clinical diagnosis of DLB (n=21), AD (n=21), and cognitively normal subjects (n=42). Hippocampal atrophy, global cortical PiB retention and occipital lobe metabolism in combination distinguished DLB from AD better than any of the measurements alone (area under the receiver operating characteristic=0.98).Five of the DLB and AD patients who underwent autopsy were distinguished through multimodality imaging. These data demonstrate that MRI and PiB PET contribute to characterizing the distinct pathological mechanisms in patients with AD compared to DLB. Occipital and posterior parietotemporal lobe hypometabolism is a distinguishing feature of DLB and this regional hypometabolic pattern is independent of the amyloid pathology.

Kantarci, Kejal; Lowe, Val J.; Boeve, Bradley F.; Weigand, Stephen D.; Senjem, Matthew L.; Przybelski, Scott A.; Dickson, Dennis W.; Parisi, Joseph E.; Knopman, David S.; Smith, Glenn E.; Ferman, Tanis J.; Petersen, Ronald C.; Jack, Clifford R.

2011-01-01

361

EEG findings in dementia with Lewy bodies and Alzheimer's disease  

PubMed Central

OBJECTIVES—To evaluate the role of the EEG in the diagnosis of dementia with Lewy bodies (DLB).?METHODS—Standard EEG recordings from 14 patients with DLB confirmed at postmortem were examined and were compared with the records from 11 patients with Alzheimer's disease confirmed at postmortem?RESULTS—Seventeen of the total of 19 records from the patients with DLB were abnormal. Thirteen showed loss of alpha activity as the dominant rhythm and half had slow wave transient activity in the temporal lobe areas. This slow wave transient activity correlated with a clinical history of loss of consciousness. The patients with Alzheimer's disease were less likely to show transient slow waves and tended to have less marked slowing of dominant rhythm.?CONCLUSIONS—The greater slowing of the EEG in DLB than in Alzheimer's disease may be related to a greater loss of choline acetyltransferase found in DLB. Temporal slow wave transients may be a useful diagnostic feature in DLB and may help to explain the transient disturbance of consciousness which is characteristic of the disorder.??

Briel, R; McKeith, I; Barker, W; Hewitt, Y; Perry, R; Ince, P; Fairbairn, A

1999-01-01

362

Reference Values and Biological Variation for Tumor Marker CA 19-9 in Serum for Different Lewis and Secretor Genotypes and Evaluation of Secretor and Lewis Genotyping in a Caucasian Population  

Microsoft Academic Search

The concentration of the tumor marker CA 19-9 is influenced by the patient's secretor status and Lewis genotype. The aim of this study was to establish novel reference intervals for CA 19-9 in serum based on secretor and Lewis genotypes, to investigate the biolog- ical variation of CA 19-9, and to evaluate the utility of Lewis and secretor genotyping on

Else Marie Vestergaard; Hans Ole Hein; Harald Meyer; Niels Grunnet; Jan Jørgensen; Hans Wolf; Torben F. Ørntoft

363

Pathways of nitrogen assimilation in cowpea nodules studied using ¹⁵Nâ and allopurinol. [Vigna unguiculata L. Walp. cv Vita  

Microsoft Academic Search

In the presence of 0.5 millimolar allopurinol (4-hydroxypyrazolo (3,4-d)pyrimidine), an inhibitor of NAD:xanthine oxidoreductase (EC 1.2.3.2), intact attached nodules of cowpea (vigna unguiculata L. Walp. cv Vita 3) formed (¹⁵N)xanthine from ¹⁵Nâ at rates equivalent to those of ureide synthesis, confirming the direct assimilation of fixed nitrogen into purines. Xanthine accumulated in nodules and was exported in increasing amounts in

C. A. Atkins; P. J. Storer; J. S. Pate

1988-01-01

364

Low sensitivity in clinical diagnoses of dementia with Lewy bodies  

PubMed Central

The success of future neurodegenerative disease (ND) therapies depends partly on accurate antemortem diagnoses. Relatively few prior studies have been performed on large, multicenter-derived datasets to test the accuracy of final clinical ND diagnoses in relation to definitive neuropathological findings. Data were analyzed from the University of Kentucky Alzheimer's Disease Center autopsy series and from the National Alzheimer's Coordinating Center (NACC) registry. NACC data are derived from 31 different academic medical centers, each with strong clinical expertise and infrastructure pertaining to NDs. The final clinical diagnoses were compared systematically with subsequent neuropathology diagnoses. Among subjects meeting final inclusion criteria (N = 2,861 for NACC Registry data), the strength of the associations between clinical diagnoses and subsequent ND diagnoses was only moderate. This was particularly true in the case of dementia with Lewy bodies (DLB): the sensitivity of clinical diagnoses was quite low (32.1% for pure DLB and 12.1% for Alzheimer's disease (AD + DLB) although specificity was over 95%. AD clinical diagnoses were more accurate (85.0% sensitivity and 51.1% specificity). The accuracy of clinical DLB diagnoses became somewhat lower over the past decade, due apparently to increased “over-calling” the diagnosis in patients with severe cognitive impairment. Furthermore, using visual hallucinations, extrapyramidal signs, and/or fluctuating cognition as part of the clinical criteria for DLB diagnosis was of minimal utility in a group (N = 237) with high prevalence of severe dementia. Our data suggest that further work is needed to refine our ability to identify specific aging-related brain disease mechanisms, especially in DLB.

Jicha, Gregory A.; Kryscio, Richard J.; Abner, Erin L.; Schmitt, Frederick A.; Cooper, Gregory; Xu, Li O.; Smith, Charles D.; Markesbery, William R.

2010-01-01

365

Properties of Lewis Lung Carcinoma Cells Surviving Curcumin Toxicity  

PubMed Central

The anti-inflammatory agent curcumin can selectively eliminate malignant rather than normal cells. The present study examined the effects of curcumin on the Lewis lung carcinoma (LLC) cell line and characterized a subpopulation surviving curcumin treatments. Cell density was measured after curcumin was applied at concentrations between 10 and 60 ?M for 30 hours. Because of the high cell loss at 60 ?M, this dose was chosen to select for surviving cells that were then used to establish a new cell line. The resulting line had approximately 20% slower growth than the original LLC cell line and based on ELISA contained less of two markers, NF-?B and ALDH1A, used to identify more aggressive cancer cells. We also injected cells from the original and surviving lines subcutaneously into syngeneic C57BL/6 mice and monitored tumor development over three weeks and found that the curcumin surviving-line remained tumorigenic. Because curcumin has been reported to kill cancer cells more effectively when administered with light, we examined this as a possible way of enhancing the efficacy of curcumin against LLC cells. When LLC cells were exposed to curcumin and light from a fluorescent lamp source, cell loss caused by 20 ?M curcumin was enhanced by about 50%, supporting a therapeutic use of curcumin in combination with white light. This study is the first to characterize a curcumin-surviving subpopulation among lung cancer cells. It shows that curcumin at a high concentration either selects for an intrinsically less aggressive cell subpopulation or generates these cells. The findings further support a role for curcumin as an adjunct to traditional chemical or radiation therapy of lung and other cancers.

Yan, Dejun; Geusz, Michael E.; Jamasbi, Roudabeh J.

2012-01-01

366

Reaction of frustrated Lewis pairs with ketones and esters.  

PubMed

The frustrated Lewis pair (FLP) Mes(2)PCH(2)CH(2)B(C(6)F(5))(2) (1) reacts with an enolizable conjugated ynone by 1,4-addition involving enolate tautomerization to give an eight-membered zwitterionic heterocycle. The conjugated endione PhCO-CH=CH-COPh reacts with the intermolecular FLP tBu(3)P/B(C(6)F(5))(3) by a simple 1,4-addition to an enone subunit. The same substrate undergoes a more complex reaction with the FLP 1 that involves internal acetal formation to give a heterobicyclic zwitterionic product. FLP 1 reacts with dimethyl maleate by selective overall addition to the C=C double bond to give a six-membered heterocycle. It adds analogously to the triple bond of an acetylenic ester to give a similarly structured six-membered heterocycle. The intermolecular FLP P(o-tolyl)(3)/B(C(6)F(5))(3) reacts analogously with acetylenic ester by trans-addition to the carbon-carbon triple bond. An excess of the intermolecular FLP tBu(3)P/B(C(6)F(5))(3), which contains a more nucleophilic phosphane, reacts differently with acetylenic ester examples, namely by O-C(alkyl) bond cleavage to give the {R-CO(2)[B(C(6)F(5))(3)](2)(-)}[alkyl-PtBu(3)(+)] salts. Simple aryl or alkyl esters react analogously by using the borane-stabilized carboxylates as good leaving groups. All essential products were characterized by X-ray diffraction. PMID:22407845

Xu, Bao-Hua; Yanez, Raul Alfonso Adler; Nakatsuka, Hiroshi; Kitamura, Masato; Fröhlich, Roland; Kehr, Gerald; Erker, Gerhard

2012-03-07

367

Effects of Lewis number on turbulent scalar transport and its modelling in turbulent premixed flames  

SciTech Connect

The behaviour of the turbulent scalar flux in premixed flames has been studied using Direct Numerical Simulation (DNS) with emphasis on the effects of Lewis number in the context of Reynolds-averaged closure modelling. A database was obtained from DNS of three-dimensional freely propagating statistically planar turbulent premixed flames with simplified chemistry and a range of global Lewis numbers from 0.34 to 1.2. Under the same initial conditions of turbulence, flames with low Lewis numbers are found to exhibit counter-gradient transport, whereas flames with higher Lewis numbers tend to exhibit gradient transport. The Reynolds-averaged transport equation for the turbulent scalar flux is analysed in detail and the performance of existing models for the unclosed terms is assessed with respect to corresponding quantities extracted from DNS data. Based on this assessment, existing models which are able to address the effects of non-unity Lewis number on turbulent scalar flux transport are identified, and new or modified models are suggested wherever necessary. In this way, a complete set of closure models for the scalar flux transport equation is prescribed for use in Reynolds-Averaged Navier-Stokes simulations. (author)

Chakraborty, Nilanjan [Engineering Department, University of Liverpool, Brownlow Hill, Liverpool L69 3GH (United Kingdom); Cant, R.S. [Cambridge University Engineering Department, Trumpington Street, Cambridge CB2 1PZ (United Kingdom)

2009-07-15

368

Into the Wardrobe: A Web Site Devoted to C.S. Lewis  

NSDL National Science Digital Library

C.S. Lewis was a man who wore many hats during his lifetime, although he is best remembered today by the general public as the author of the Chronicles of Narnia series. However, Lewis also published ground-breaking works that examined the function of allegory in medieval literature and was respected for his Christian apologetics. This site honors Lewis's life and substantial body of work, and was developed by an aficionado of his works. Visitors to the site can peruse a brief biographical sketch of Lewis, along with browsing through a bibliography of his published works. The "Related Resources" section is quite helpful, as it contains links to sites dealing with his contemporaries, including Madeleine L'Engle, G.K. Chesterton, and J.R.R. Tolkien. The multimedia section of the site is quite compelling, as it contains a large photo gallery and a selection of audio clips. The clips feature Lewis talking about the idea of Christian love, and noted thespians Anthony Quayle, Ian Richardson, and Claire Bloom reading selections from his novels.

369

Dissociation Between the Aversive and Pharmacokinetic Effects of Ethanol in Female Fischer and Lewis Rats  

PubMed Central

In humans and laboratory animal models, vulnerability to alcohol abuse is influenced by endogenous factors such as genotype. Using the inbred Fischer and Lewis rat strains, we previously reported stronger conditioned taste aversions (CTA) in male Fischer rats that could not be predicted by genotypic differences in alcohol absorption [34]. The present study made similar assessments in Fischer and Lewis females via four-trial CTA induced by 1 or 1.5 g/kg intraperitoneal (IP) ethanol (n = 10-12/strain/dose) as well as measures of blood alcohol concentrations (BAC) at 15, 60 and 180 min post-injection with 1.5 g/kg IP ethanol or saline (n = 7-8/strain/dose). Dose-dependent CTAs were produced, but the strains did not differ from each other in these measures; however, BACs in the Lewis females were significantly higher than Fischer at all three time points. As with males of the Fischer and Lewis genotypes, a dissociation between BACs and the aversive effects of alcohol was observed. These data are the first assessments of these particular phenotypes in Fischer and Lewis females, and when considered with the historical data, suggest a Genotype × Sex interaction in the centrally-mediated sensitivity to alcohol's aversive effects.

Roma, Peter G.; Chen, Scott A.; Barr, Christina S.; Riley, Anthony L.

2007-01-01

370

Strain differences in mesotelencephalic dopaminergic neuronal regulation between Fischer 344 and Lewis rats.  

PubMed

Differences in the behavioral responses of Lewis and Fischer (F344) inbred rat strains to stress and psychoactive drugs have been related to differences in the expression of various regulatory proteins in regions containing mesolimbic dopamine (DA) neurons. The present study compared basal and stimulated neurochemical estimates of DA utilization and synthesis in mesocortical, mesolimbic and nigrostriatal DA terminal regions of these two strains. In unstressed control animals, the Lewis strain had lower DA concentrations in the dorsal striatum (ST; 80.3% of F344) and lower basal dihydroxyphenylalanine (DOPA) accumulation after m-hydroxybenzylhydrazine (NSD 1015) treatment in the medial prefrontal cortex (mPfx; 75.3% of F344). Similar differences were observed in vehicle-injected animals. No strain differences in basal neurochemistry were apparent in the nucleus accumbens shell (NAs) or core (NAc). In response to restraint stress, dihydroxyphenylacetic acid (DOPAC) to DA ratios in the mPfx, NAs and ST increased in the F344 but not the Lewis strain. However, restraint stress did not significantly increase DOPA accumulation in the F344 strain. This latter finding was not due to a deficit in synthesis capacity, as gamma-hydroxybutyric acid lactone (GBL) increased DOPA accumulation significantly more in F344 than Lewis animals. Finally, haloperidol increased DA utilization similarly in the two strains. Together these findings suggest that the inbred, behaviorally divergent F344 and Lewis rats have selective differences in mesocortical, nigrostriatal and mesolimbic DA neuronal regulation. PMID:10375661

Lindley, S E; Bengoechea, T G; Wong, D L; Schatzberg, A F

1999-06-19

371

Adventures in Ichthyology: Pacific Northwest Fishes of the Lewis and Clark Expedition  

SciTech Connect

Captains Meriwether Lewis and William Clark and other members of their expedition collected and identified nearly 400 species of plants and animals during the Voyage of Discovery. Of this total, 31 species of fish were included in Burrough’s summary of the natural history of the Expedition, including 12 fishes considered unknown to science at that time. While there is little doubt of the identity of fish for which Lewis and Clark provided detailed descriptions in their daily logs, other species designations were largely conjecture based on later scholars interpretation of the Lewis and Clarks account. Unlike other biological specimens encountered during the Expedition, no fishes were brought back for study. As a result, the identity of some fishes was never resolved. Many other fishes were reclassified during the past century based on updated scientific methods.

Dauble, Dennis D.

2005-09-01

372

Lewis-Acid/Base Effects on Gallium Volatility in Molten Chlorides  

SciTech Connect

It has been proposed that GaCl{sub 3} can be removed by direct volatilization from a Pu-Ga alloy that is dissolved in a molten chloride salt. Although pure GaCl{sub 3} is quite volatile (boiling point, 201 C), the behavior of GaCl{sub 3} dissolved in chloride salts is different due to solution effects and is critically dependent on the composition of the solvent salt (i.e., its Lewis-acid/base character). In this report, the behavior of gallium in prototypical Lewis-acid and Lewis-base salts is compared. It was found that gallium volatility is suppressed in basic melts and enhanced in acidic melts. The implications of these results on the potential for simple gallium removal in molten salt systems are significant.

Williams, D.F.

2001-02-26

373

Power System Reliability Assessment by Analysing Voltage Dips on the Blue Horizon Bay 22KV Overhead Line in the Nelson Mandela Bay Municipality  

NASA Astrophysics Data System (ADS)

Power system reliability problems are very difficult to solve because the power systems are complex and geographically widely distributed and influenced by numerous unexpected events. It is therefore imperative to employ the most efficient optimization methods in solving the problems relating to reliability of the power system. This paper presents a reliability analysis and study of the power interruptions resulting from severe power outages in the Nelson Mandela Bay Municipality (NMBM), South Africa and includes an overview of the important factors influencing reliability, and methods to improve the reliability. The Blue Horizon Bay 22 kV overhead line, supplying a 6.6 kV residential sector has been selected. It has been established that 70% of the outages, recorded at the source, originate on this feeder.

Lamour, B. G.; Harris, R. T.; Roberts, A. G.

2010-06-01

374

Dementia With Lewy Bodies: Diagnosis and Management for Primary Care Providers  

PubMed Central

Objective: The purpose of this review is to aid primary care providers in distinguishing dementia with Lewy bodies (DLB) from Alzheimer's disease and from Parkinson's disease with dementia. Differentiating these entities has important treatment implications. Data Sources: A PubMed search was undertaken using the keywords Lewy body dementia, dementia with Lewy bodies, and Lewy body disease. There were no date restrictions. Only articles in the English language were reviewed. References of selected articles were reviewed for additional sources. Data Selection and Extraction: Initially, 2,967 articles were retrieved. All 3 authors participated in data selection and extraction. Articles were further selected for content specific to epidemiology, clinical presentation, diagnostic studies, treatment, and prognosis. For articles with repetitive information, the most current article was used. This resulted in a total of 62 articles included in the review. Data Synthesis: Dementia with Lewy bodies is the second leading cause of dementia after Alzheimer's disease. The core symptoms of DLB, including cognitive fluctuations, visual hallucinations, and parkinsonism, may not always be present as a triad, and clinicians may be unaware of associated symptoms. Thus, this diagnosis is frequently missed by primary care providers. Often, DLB is misdiagnosed as Alzheimer's disease, Parkinson's disease, or a primary psychiatric illness. Treatments for DLB include cholinesterase inhibitors and N-methyl-D-aspartate antagonists. Antipsychotics should be avoided or used with caution. Conclusions: Dementia with Lewy bodies is an often missed diagnosis. Symptoms are often attributed to other disorders. A high clinical suspicion is helpful in accurate diagnosis, and presence of any of the core symptoms should initiate clinical suspicion of DLB. Distinguishing DLB from other disorders has important treatment implications.

Mahajan, Aman; Handa, Kamna

2011-01-01

375

Evaluation of a Stirling engine heater bypass with the NASA Lewis nodal-analysis performance code  

SciTech Connect

In support of the US Department of Energy's Stirling Engine Highway Vehicle Systems program, the NASA Lewis Research Center investigated whether bypassing the P-40 Stirling engine heater during regenerative cooling would improve the engine thermal efficiency. The investigation was accomplished by using the Lewis nodal-analysis Stirling engine computer model. Bypassing the P-40 Stirling engine heater at full power resulted in a rise in the indicated thermal efficiency from 40.6 to 41.0 percent. For the idealized (some losses not included) heater bypass that was analyzed, this benefit is not considered significant.

Sullivan, T.J.

1986-05-01

376

Dietary supplementation with methylseleninic acid, but not selenomethionine, reduces spontaneous metastasis of Lewis lung carcinoma in mice  

Technology Transfer Automated Retrieval System (TEKTRAN)

Dietary supplementation with methylseleninic acid reduces spontaneous metastasis of Lewis lung carcinoma in mice Lin Yan*, Lana C. DeMars The present study investigated the effects of dietary supplementation with methylseleninic acid (MSeA) on spontaneous metastasis of Lewis lung carcinoma (LLC) in...

377

"OrganicPad": An Interactive Freehand Drawing Application for Drawing Lewis Structures and the Development of Skills in Organic Chemistry  

ERIC Educational Resources Information Center

|Lewis structures are important for learning chemistry as they serve as an essential link between the structure of chemical compounds and their function. Unfortunately, the creation of valid Lewis structures remains an elusive goal for many students. In recent years, several web-based programs have been created that allow students to receive…

Cooper, Melanie M.; Grove, Nathaniel P.; Pargas, Roy; Bryfczynski, Sam P.; Gatlin, Todd

2009-01-01

378

Original Article Limbic Lobe Microvacuolation is Minimal in Alzheimer's Disease in the Absence of Concurrent Lewy Body Disease  

Microsoft Academic Search

Microvacuolation is relatively common in the limbic lobe in Lewy body disease (LBD). Similar pathology has also been reported in Alzheimer's disease (AD). Almost all of the studies of microvacuolation in AD, however, antedated the routine application of sensitive immunohistochemical methods to detect Lewy bodies. This raises the possibility that microvacuolation previously reported in AD may have been due to

Yasuhiro Fujino; Dennis W. Dickson

379

Convective heat transfer measurements from a NACA 0012 airfoil in flight and in the NASA Lewis Icing Research Tunnel  

Microsoft Academic Search

Local heat transfer coefficients were measured on a smooth and roughened NACA 0012 airfoil. Heat transfer measurements on the 0.533 m chord airfoil were made both in flight on the NASA Lewis Twin Otter Icing Research Aircraft and in the NASA Lewis Icing Research Tunnel (IRT). Roughness was obtained by the attachment of uniform 2 mm diameter hemispheres to the

Philip E. Poinsatte; G. James Vanfossen; Kenneth J. Dewitt

1989-01-01

380

Olfactory impairment is more marked in patients with mild dementia with Lewy bodies than those with mild Alzheimer disease  

Microsoft Academic Search

Background:Dementia patients with anosmia are more likely to have Lewy body pathology at postmortem, but clinicopathological studies have only assessed olfaction in moderate dementia or an average of 5 years before death. It is not known whether, in patients with mild dementia (MMSE score over 20), olfactory function is more impaired in Alzheimer disease (AD) than dementia with Lewy bodies

S S Williams; J Williams; M Combrinck; S Christie; A D Smith; R McShane

2009-01-01

381

Selective Molecular Alterations in the Autophagy Pathway in Patients with Lewy Body Disease and in Models of alpha-Synucleinopathy  

Microsoft Academic Search

BackgroundLewy body disease is a heterogeneous group of neurodegenerative disorders characterized by ?-synuclein accumulation that includes dementia with Lewy bodies (DLB) and Parkinson's Disease (PD). Recent evidence suggests that impairment of lysosomal pathways (i.e. autophagy) involved in ?-synuclein clearance might play an important role. For this reason, we sought to examine the expression levels of members of the autophagy pathway

Leslie Crews; Brian Spencer; Paula Desplats; Christina Patrick; Amy Paulino; Edward Rockenstein; Lawrence Hansen; Anthony Adame; Douglas Galasko; Eliezer Masliah; Tsuneya Ikezu

2010-01-01

382

Hero or Hypocrite?United States and International Media Portrayals of Carl Lewis Amid Revelations of a Positive Drug Test  

Microsoft Academic Search

This article examines press coverage of track and field athlete Carl Lewis amid reports in April 2003 that he tested positive for three banned stimulants prior to United States Olympic Trials in 1988. Lewis, of course, won the 1988 100-meter gold medal after Canadian Ben Johnson tested positive for anabolic steroids, a development that brought disgrace to Johnson and adulation

Bryan E. Denham

2004-01-01

383

Neuronal histamine production remains unaltered in Parkinson's disease despite the accumulation of Lewy bodies and Lewy neurites in the tuberomamillary nucleus.  

PubMed

Neuronal histamine production in the hypothalamic tuberomamillary nucleus (TMN) was hypothesized to change significantly in Parkinson's disease (PD) in relation to the accumulation of Lewy bodies/Lewy neurites (LBs/LNs). We measured the messenger ribonucleic acid (mRNA) levels of histidine decarboxylase (HDC), the key enzyme of histamine production, and the amount of LBs/LNs in the TMN by quantitative in situ hybridization and immunocytochemistry in postmortem human brain material of clinical PD (CPD), preclinical PD, and control subjects. No significant difference of histidine decarboxylase mRNA levels was observed among different clinical or Braak-PD stages, in spite of the strong accumulation of LBs/LNs in the TMN of clinical PD patients. We conclude that neuronal histamine production remains largely unaltered in PD despite the abundant LB/LN accumulation in the TMN. PMID:21371786

Shan, Ling; Liu, Chun-Qing; Balesar, Rawien; Hofman, Michel A; Bao, Ai-Min; Swaab, Dick F

2011-03-02

384

Distinct Substrate Specificities of Five Human ?-1,3-Fucosyltransferases for in VivoSynthesis of the Sialyl Lewis x and Lewis x Epitopes  

Microsoft Academic Search

Five different human ?-1,3-fucosyltransferase genes,the Fuc-TIII, Fuc-TIV, Fuc-TV, Fuc-TVIandFuc-TVIIgenes, have been cloned to date. We transfected HeLa cells and Namalwa cells with each of the five different genes, and established a series of stable cloned transformant cells. Thin-layer chromatography immunostaining analysis revealed that all five enzymes were able to synthesize sialyl Lewis x (sLex) epitopes on glycolipids in HeLa cells,

Hirohisa Kimura; Naoko Shinya; Shoko Nishihara; Mika Kaneko; Tatsuro Irimura; Hisashi Narimatsu

1997-01-01

385

Shallow-water and sub-storm-base deposition of Lewis Shale in Cretaceous Western interior seaway, south-central Wyoming  

Microsoft Academic Search

Shallow- and deep-water (below storm base) clastics of the Lewis Shale were deposited in south-central Wyoming during a part of the Late Cretaceous Core, log, and outcrop data indicate that the Lewis Shale consists of a thin, transgressive, marine shale overlain by a thicker, coarser, progradational interval. The sea in which the Lewis Shale was deposited opened eastward into the

R. D. Jr. Winn; M. G. Bishop; P. S. Gardner

1987-01-01

386

Lewis y antigen promotes the proliferation of ovarian carcinoma-derived RMG-I cells through the PI3K\\/Akt signaling pathway  

Microsoft Academic Search

BACKGROUND: Lewis y antigen is difucosylated oligosaccharide and is carried by glycoconjugates at cell surface. Elevated expression of Lewis y has been found in 75% of ovarian tumor, and the high expression level is correlated to the tumor's pathological staging and prognosis. This study was to investigate the effect and the possible mechanism of Lewis y on the proliferation of

Juanjuan Liu; Bei Lin; Yingying Hao; Yue Qi; Liancheng Zhu; Feifei Li; Dawo Liu; Jianping Cong; Shulan Zhang; Masao Iwamori

2009-01-01

387

LEWIS FRY RICHARDSON AND HIS CONTRIBUTIONS TO MATHEMATICS, METEOROLOGY, AND MODELS OF CONFLICT  

Microsoft Academic Search

The life and major scientific contributions of Lewis Fry Richardson (1881-1953) are reviewed, with particular emphasis on his pioneering work in numerical anal- ysis, meteorology, and numerical weather prediction. His later work on mathe- matical modeling of psychology, causes of conflict, and the statistics of wars is outlined in terms understandable to fluid dynamicists. It is included because it led

J. C. R. Hunt

1998-01-01

388

Lewis Fry Richardson and his Contributions to Mathematics, Meteorology, and Models of Conflict  

Microsoft Academic Search

The life and major scientific contributions of Lewis Fry Richardson (1881-1953) are reviewed, with particular emphasis on his pioneering work in numerical analysis, meteorology, and numerical weather prediction. His later work on mathematical modeling of psychology, causes of conflict, and the statistics of wars is outlined in terms understandable to fluid dynamicists. It is included because it led to Richardson's

J. C. R. Hunt

1998-01-01

389

Lewis Base Directed Cycloaddition Reactions of 2-Pyrones and Alkynylaluminum Reagents  

PubMed Central

In situ generated alkynylaluminum reagents have been utilized in a [4 + 2] cycloaddition with 2-pyrones bearing a Lewis basic donor. The reactions proceed at or below room temperature and with complete regiocontrol. This one-pot method affords diversely substituted aromatic compounds under very mild conditions.

2013-01-01

390

Stress and Burden among Caregivers of Patients with Lewy Body Dementia  

ERIC Educational Resources Information Center

|Purpose: Patients with Lewy body dementia (LBD) may present a unique set of symptoms and challenges to family caregivers compared with other types of dementia. Prominent difficulties include motor impairment, activities of daily living (ADLs) disability, recurrent behavioral and emotional problems (BEPs), and diagnostic difficulties. These…

Leggett, Amanda N.; Zarit, Steven; Taylor, Angela; Galvin, James E.

2011-01-01

391

Dorsal Motor Nucleus of Vagus protein aggregates in Lewy Body Disease with autonomic dysfunction  

Microsoft Academic Search

The Dorsal Motor Nucleus of Vagus (DMV) is degenerated in many patients with early stage Lewy Body Diseases (LBD). Many patients with LBD also develop symptomatic autonomic dysfunction prior to motor and cognitive symptoms. The DMV, along with the Nucleus Ambiguous (NA) and Raphe Obscurus (RO) regulates a variety of autonomic reflexes, suggesting that there may be an association between

Veronica M. Miller; Rose Anne Kenny; Arthur E. Oakley; Ros Hall; Rajesh N. Kalaria; Louise M. Allan

2009-01-01

392

Fragment of an Interview with Governor Mario Cuomo and Interview with Richard Lewis.  

ERIC Educational Resources Information Center

|Former New York governor Mario Cuomo discusses the inequities of public schooling, the trend toward charter schools, and the importance of making education a national priority. Richard Lewis, founder and director of the Touchstone Center (New York City), discusses children's literature, the intrinsic motivation that children have for learning,…

Mercogliano, Chris; Leue, Mary

1997-01-01

393

Effects of dietary fat on spontaneous metastasis of Lewis lung carcinoma in mice  

Technology Transfer Automated Retrieval System (TEKTRAN)

The present study assessed the effects of dietary fat on spontaneous metastasis of Lewis lung carcinoma in mice. Three-week old male C57BL/6 mice were fed the AIN-93G standard diet or a 45% fat diet (kcal %) for seven weeks before they were subcutaneously injected with 2.5 x 105 viable cells into th...

394

Lewis Acid Mediated (3 + 2) Cycloadditions of Donor-Acceptor Cyclopropanes with Heterocumulenes  

PubMed Central

Isocyanates, isothiocyanates, and carbodiimides are effective substrates in (3 + 2) cycloadditions with donor–acceptor cyclopropanes for the synthesis of five-membered heterocycles. These reactions exhibit a broad substrate scope, high yields, and well-defined chemoselectivity. Discussed herein are the implications of Lewis acid choice on the stereochemical outcome and the reaction mechanism.

Goldberg, Alexander F. G.; O'Connor, Nicholas R.; Craig, Robert A.; Stoltz, Brian M.

2012-01-01

395

Neuropsychological Assessment of Dementia with Lewy Bodies: Comparison with Alzheimer' s Disease - A Preliminary Study  

Microsoft Academic Search

B a c k g r o u n d: Dementia with Lewy bodies (DLB) is now considered to be the second most common pathological cause of dementia after Alzheimer's dementia (AD). Little has been known about differences in the neuropsychological assessment between DLB and AD. The aim of this study is to assess the pattern of cognitive impairment in

Kyung Won Park; Jae Woo Kim

396

Neuropsychological Differentiation of Dementia with Lewy Bodies from Normal Aging and Alzheimer's Disease  

Microsoft Academic Search

We examined the diagnostic utility of selected neuropsychological measures in the differentiation of dementia with Lewy bodies (DLB) from normal aging and Alzheimer's disease (AD). Patients with DLB (n = 87), AD (n = 138), and a group of normal controls (n = 103) were recruited from the Mayo Alzheimer's disease patient registry and Alzheimer's Disease Research Center. Neuropsychological measures shown to have utility in previous

Tanis J. Ferman; Glenn E. Smith; Bradley F. Boeve; Neill R. Graff-Radford; John A. Lucas; David S. Knopman; Ronald C. Petersen; Robert J. Ivnik; Zbigniew Wszolek; Ryan Uitti; Dennis W. Dickson

2006-01-01

397

Paleoenvironments of upper Cretaceous Lewis Shale and Fox Hills Formation, south-central Wyoming  

Microsoft Academic Search

The Maestrichtian Lewis Shale and Fox Hills Formation in south-central Wyoming were deposited during the final major transgression and regression of the North American epicontinental sea. Outcrops of these formations were examined along the margins of the Great Divide, Washakie, Hanna, and Carbon basins. Bore-hole logs from approximately 200 wells within these basins were studied and correlated with outcrops. Lists

Roseanne C. Perman

1988-01-01

398

Overview of the 1985 NASA Lewis Research Center SP100 free-piston Stirling engine activities  

Microsoft Academic Search

An overview of the 1985 (NASA) Lewis Research Center free-piston Stirling engine activities in support of the SP-100 Program is presented. The SP-100 program is being conducted in support of the Department of Advanced Research Projects Agency (DARPA) and the Department of Energy (DOE), and NASA. This effort is keyed on the design, fabrication, assembly, and testing of a 25

Slaby

1985-01-01

399

Effects of amphetamine and cocaine on the development of acute experimental allergic encephalomyelitis in Lewis rats  

Microsoft Academic Search

The present experiment deals with the effects of amphetamine and cocaine on the development and course of experimental allergic encephalomyelitis (EAE) induced in Lewis rats. Rats were immunized at the age of eight weeks with purified myelin basic protein isolated from guinea pig brain in complete Freund's adjuvant. Drug administration and recording of EAE clinical signs was performed daily since

María J Núñez; José Balboa; Manuel Rey-Méndez; Julio Brenlla; Mercedes González-Peteiro; Elena Rodrigo; Manuel Freire-Garabal

2007-01-01

400

Window of Opportunity: The Climatic Conditions of the Lewis and Clark Expedition of 1804 1806  

Microsoft Academic Search

Lewis and Clark's entry into to the American West in search of an inland Northwest Passage is considered among the greatest expeditions in American history. The Corps of Discovery were also lucky as their travels west of the 100th meridian occurred during a ``window'' of generally favorable climatic conditions. Use of reconstructed summer Palmer drought severity index (PDSI) values from

Paul A. Knapp

2004-01-01

401

Into the Unknown: The Logistics Preparation of the Lewis and Clark Expedition.  

National Technical Information Service (NTIS)

Captain Meriwether Lewis' task was to equip and man a party to traverse the unmapped middle third of the United States. Most studies of the expedition begin with the party's departure from Camp Dubois in the spring of 1804. This starting point ignores the...

D. L. Carr

2003-01-01

402

Enhanced stage and stage variability on the lower Missouri River benchmarked by Lewis and Clark  

Microsoft Academic Search

Data from the 1803 1806 Lewis and Clark expedition and nineteenth century stage records are used to quantitatively benchmark natural, premanagement hydrology of the lower Missouri River and assess the magnitude and timing of hydrologic change over nearly two centuries. Data show doubling in daily stage variability from the nineteenth century to 2005. Annual maximum stages have, at some sites,

Bethany L. Ehlmann; Robert E. Criss

2006-01-01

403

Fish Discoveries by the Lewis and Clark and Red River Expeditions  

Microsoft Academic Search

The Lewis and Clark Expedition of 1804–1806 and the Red River Expedition of 1806 were two early explorations of the land acquired by the United States in the Louisiana Purchase in western North America. They were the first such western excursions to include natural history investigations as part of the trip objectives—a reflection of Thomas Jefferson's strong scientific curiosity. Whereas

John R. Moring

1996-01-01

404

Re-making the Teton identity by celebrating ‘Lewis and Clark’  

Microsoft Academic Search

This article examines an attempt to re-make the Teton identity at the site of the bicentennial celebrations of the Lewis and Clark Expedition of 1804–1806. The pageant took place in Fort Pierre, South Dakota, in September 2004 at the initiative of the Lakota Heritage Society. The author observed and recorded the performance as a part of his ethnographic fieldwork. The

Alexander Kozin

2010-01-01

405

A. G. Vernon Harcourt: A Founder of Chemical Kinetics and a Friend of "Lewis Carroll."  

ERIC Educational Resources Information Center

|Outlines the life of A. G. Vernon Harcourt, a founder of chemical kinetics, contributor to the purification of coal gas from sulfur compounds, inventor of the percentage chloroform inhaler, friend to Lewis Carroll, and instructor to the Prince of Wales. (CS)|

Shorter, John

1980-01-01

406

Overview of the 1986 Free-Piston Stirling Activities at NASA Lewis Research Center.  

National Technical Information Service (NTIS)

An overview of the NASA Lewis Research Center's free-piston Stirling engine research is presented. The latter includes efforts to improve and advance the design of free-piston Stirling engines for use in specific space power applications. These efforts ar...

D. L. Alger

1986-01-01

407

Let Us Give Lewis Acid-Base Theory the Priority It Deserves  

ERIC Educational Resources Information Center

|The application of Lewis concept that provides students opportunity to predict and understand reaction behavior and themes in introductory chemistry of structure-property relationships of atoms, ions, and molecules is narrated. The general sequence takes the student through atomic structural theory, electronic configuration, periodicity, chemical…

Shaffer, Alan A.

2006-01-01

408

Contribution of Lewy Body Inclusions to Dementia in Patients With and Without Alzheimer Disease Neuropathological Conditions  

Microsoft Academic Search

Context: Lewy bodies (LBs) are intraneuronal inclu- sions in the brain that have been increasingly recog- nized as neuropathological lesions with relevance not only to Parkinson disease but also to Alzheimer disease. How- ever, the degree to which the density of LBs in the brain contributes to the severity of dementia has not been clear. Objective: To determine the degree

Vahram Haroutunian; Michael Serby; Dushyant P. Purohit; Daniel P. Perl; Deborah Marin; Melinda Lantz; Richard C. Mohs; Kenneth L. Davis

2000-01-01

409

Lewis Temple and Hunting the Whale (VHS 1/2 inch) (Video).  

National Technical Information Service (NTIS)

An excellent presentation about the contribution of an African American, Lewis Temple, during the first half of the 19th century. This period was the highlight of the golden age of whaling and was an exciting time for the world's whaling craft. There was ...

1987-01-01

410

Lewis Temple and Hunting the Whale (VHS 3/4 inch) (Video).  

National Technical Information Service (NTIS)

An excellent presentation about the contribution of an African American, Lewis Temple, during the first half of the 19th century. This period was the highlight of the golden age of whaling and was an exciting time for the world's whaling craft. There was ...

1987-01-01

411

"Thoughts across My Corpus Callosum": What Lewis Thomas's Essays Can Teach Students about Writing Well.  

ERIC Educational Resources Information Center

As Lewis Thomas has maintained, much of today's public anxiety about science is the apprehension that the whole is being overlooked by an endless, obsessive preoccupation with the parts, and this is a suitable analogy for composition teaching. Students and teachers alike tend to fret endlessly over minute details of writing, like grammar,…

White, Fred D.

412

Cultural Mediations: Or How to Listen to Lewis and Clark's Indian Artifacts  

ERIC Educational Resources Information Center

|In this article, the author maps the complex history of objects collected on the Lewis and Clark expedition. He follows the objects from the Peale Museum where they were first exhibited to their final destination, the Peabody Museum at Harvard University. The author sheds light on how the manipulation and exhibition of one collection can…

Stevens, Scott

2007-01-01

413

Crystallization of the Lewis–Wahnstro¨m ortho-terphenyl model  

Microsoft Academic Search

Crystallization is observed during microsecond long molecular dynamics simulations of bent trimers, a molecular model proposed by Lewis and Wahnstro¨m for ortho-terphenyl. In the crystal, the three spheres that make up the rigid molecule sit near sites of a body centered cubic lattice. The trimer bond angle is almost optimal for this structure. The crystal exhibits orientational disorder with the

Ulf R. Pedersen; Toby S. Hudson; Peter Harrowell

2011-01-01

414

PREGLACIAL DEVELOPMENT OF CAVES AT STRUCTURAL DUPLEXES ON THE LEWIS THRUST, GLACIER NATIONAL PARK, MONTANA  

Microsoft Academic Search

Two significant caves in Glacier National Park are developed in Middle Proterozoic carbonate rocks. One lies within two large-scale duplex structures resting on the Lewis Thrust. The other is in the hinterland region of one of the duplexes. Both of the caves are aligned along bedding planes, joints, and faults. Poia Lake Cave has large segments that, in part, are

HANS G. BODENHAMER

415

An enzymatic ruler modulates Lewis antigen glycosylation of Helicobacter pylori LPS during persistent infection  

PubMed Central

Helicobacter pylori persistently colonizes about half the human population and contributes to the development of peptic ulcer disease and gastric cancer. This organism has evolved means to structurally alter its surface characteristics to evade innate and adaptive immune responses. H. pylori produces LPS O-antigen units that can be posttranslationally fucosylated to generate Lewis antigens, structures also found on human epithelial cells. We demonstrate an extensive diversity of Lewis x and Lewis y expression in LPS O-antigen units, occurring over time and in different regions of the human stomach. Lewis expression patterns were correlated with the on/off status of the three fucosyltransferases (FucT), FutA, FutB, and FutC, which are regulated via slipped-strand mispairing in intragenic polyC tract regions of the corresponding genes. The ?1,3-FucT, FutA and FutB, each contain a C-terminal heptad repeat region, consisting of a variable number of DD/NLRV/INY tandem repeats. Variations in the number of heptad repeats correlated to the sizes of O-antigen polymers to become decorated by fucose residues. Our data support a molecular ruler mechanism for how H. pylori varies its LPS fucosylation pattern, where one heptad repeat in the enzyme corresponds to one N-acetyl-?-lactosamine unit in the O-antigen polysaccharide.

Nilsson, Christina; Skoglund, Anna; Moran, Anthony P.; Annuk, Heidi; Engstrand, Lars; Normark, Staffan

2006-01-01

416

Lewis Structure Representation of Free Radicals Similar to ClO  

ERIC Educational Resources Information Center

|The study describes the Lewis structure representation of various free radicals, which are quite similar to the ClO radical and its isoelectronic analogues. The analysis of the periodic trends of these radicals shows that oxygen is the most electronegative atom among them.|

Hirsch, Warren; Kobrak, Mark

2007-01-01

417

Adventures in Ichthyology: Pacific Northwest Fishes of the Lewis and Clark Expedition  

Microsoft Academic Search

Captains Meriwether Lewis and William Clark and other members of their expedition collected and identified nearly 400 species of plants and animals during the Voyage of Discovery. Of this total, 31 species of fish were included in Burroughâs summary of the natural history of the Expedition, including 12 fishes considered unknown to science at that time. While there is little

Dauble; Dennis D

2005-01-01

418

Psychoanalytic Theory in the Context of Contemporary Psychology: The Helen Block Lewis Memorial Address  

Microsoft Academic Search

This article represents a tribute to the late Helen Block Lewis's commitment to integrating psychology and psychoanalysis. The current status of the formal structure of psychoanalytic theory was reviewed in relation to recent developments in general psychology. Specific attention was paid to the psychodynamic or motivational perspective, the structural perspective, and the genetic or developmental perspective as proposed by Rapaport.

Jerome L. Singer

1988-01-01

419

Paradise Lost and Found: Obedience, Disobedience, and Storytelling in C. S. Lewis and Philip Pullman  

Microsoft Academic Search

In the fantasy series The Chronicles of Narnia and His Dark Materials, by C. S. Lewis and Philip Pullman respectively, the authors use symbols and themes from Paradise Lost. Each author's narrative choice uses his view of cosmic order to persuade readers that obedience should be understood as central to coming of age. At stake is the proper role of

Naomi Wood; George MacDonald; Charles Kingsley

2001-01-01

420

Overview of Lewis Materials Research: Contributions, Current Efforts, and Future Directions.  

National Technical Information Service (NTIS)

In the 1940's, materials research efforts on high-temperature valve alloys at NASA Lewis Research Center led to the improved lives and performance of piston-engined fighter and bomber aircraft. The metallurgical skills acquired from that work were then ap...

S. J. Grisaffe C. E. Lowell

1991-01-01

421

Influence of Larval Sea Lamprey Density on Transformer Life History Characteristics in Lewis Creek, Vermont  

Microsoft Academic Search

Density-dependent larval life history characteristics of sea lampreys Petromyzon marinus may have important management implications for sea lamprey control if life history attributes directly respond to conditions created by control strategies. Our objective was to examine the effects of larval sea lamprey density on sex ratio, size at metamorphosis, and age at metamorphosis in Lewis Creek, Vermont (one reach with

Adam Zerrenner; J. Ellen Marsden

2005-01-01

422

Frequency and Case Identification of Dementia with Lewy Bodies Using the Revised Consensus Criteria  

Microsoft Academic Search

Objective: To find the proportion of dementia with Lewy bodies (DLB) in a referral cohort of patients with a first-time diagnosis of mild dementia. Background: The proportion of DLB among the dementia sufferers is not known and the clinical consensus criteria have low sensitivity. We employed the revised DLB criteria to study the proportion with DLB in a community sample

Dag Aarsland; Arvid Rongve; Sabine Piepenstock Nore; Ragnhild Skogseth; Siri Skulstad; Uwe Ehrt; Dagne Hoprekstad; Clive Ballard

2008-01-01

423

Chain-growth polymerization of 2-chlorothiophenes promoted by Lewis acids.  

PubMed

Lewis acids promote the polymerization of several 2-chloroalkylenedioxythiophenes, providing high-molecular-weight conjugated polymers. The proposed mechanism is a cationic chain-growth polymerization, as confirmed by end-capping reactions and a linear correlation of molecular weight with percent conversion. The "living" character of this process was used to prepare new block copolymers. PMID:23137337

Bonillo, Baltasar; Swager, Timothy M

2012-11-09

424

"Thoughts across My Corpus Callosum": What Lewis Thomas's Essays Can Teach Students about Writing Well.  

ERIC Educational Resources Information Center

|As Lewis Thomas has maintained, much of today's public anxiety about science is the apprehension that the whole is being overlooked by an endless, obsessive preoccupation with the parts, and this is a suitable analogy for composition teaching. Students and teachers alike tend to fret endlessly over minute details of writing, like grammar,…

White, Fred D.

425

Immunocytochemical and ultrastructural study of Lewy body-like hyaline inclusions in familial amyotrophic lateral sclerosis  

Microsoft Academic Search

Lewy body-like hyaline inclusion (LI) in the neuronal soma and swollen cord-like processes is a characteristic feature in the anterior horn cells and neurons in thoracic nucleus (Clarke) of familial amyotrophic lateral sclerosis (ALS) with posterior column involvement. We have studied the LI in the case of two sisters with this disorders. Microscopically the LI consists of an eosinophilic “core”

S. Murayama; Y. Ookawa; H. Mori; I. Nakano; Y. Ihara; S. Kuzuhara; M. Tomonaga

1989-01-01

426

Reconfiguring diaspora: Africa on the rise and the radio voices of Lewis Nkosi and Bloke Modisane  

Microsoft Academic Search

The article focuses on radio as cultural mediator and maker. It discusses a particular moment in the early 1960s when Africa seemed to those closely involved in its cultural and political affairs to be ‘on the rise’. It focuses on the role of Lewis Nkosi, and partly, too, that of Bloke Modisane, in the ‘Africa Abroad’ radio programme run from

Liz Gunner

2010-01-01

427

Excitable Dynamics in High-Lewis Number Premixed Gas Combustion at Normal and Microgravity.  

National Technical Information Service (NTIS)

Freely-propagating, premixed gas flames in high-Lewis (Le) number, quiescent mixtures are studied experimentally in tubes of various diameter at normal (lg) and microgravity (mu g). A premixture of lean butane and oxygen diluted with helium, argon, neon, ...

H. Pearlman

1995-01-01

428

Organo-Lewis acid as cocatalyst for cationic homogeneous Ziegler-Natta olefin polymerizations  

DOEpatents

Organo-Lewis acids of the formula BR'R".sub.2 wherein B is boron, R' is fluorinated biphenyl, and R" is a fluorinated phenyl, fluorinated biphenyl, or fluorinated polycyclic fused ring group, and cationic metallocene complexes formed therewith. Such complexes are useful as polymerization catalysts.

Marks, Tobin J. (Evanston, IL); Chen, You-Xian (Midland, MI)

2002-01-01

429

Organo-Lewis acid as cocatalyst for cationic homogeneous Ziegler-Natta olefin polymerizations  

DOEpatents

Organo-Lewis acids of the formula BR'R".sub.2 wherein B is boron, R' is fluorinated biphenyl, and R" is a fluorinated phenyl, fluorinated biphenyl, or fluorinated polycyclic fused ring group, and cationic metallocene complexes formed therewith. Such complexes are useful as polymerization catalysts.

Marks, Tobin J. (Evanston, IL); Chen, You-Xian (Midland, MI)

2001-01-01

430

The Lewis acid catalyzed synthesis of hyperbranched Oligo(glycerol-diacid)s in aprotic polar media  

Technology Transfer Automated Retrieval System (TEKTRAN)

The Lewis-acid, titanium (IV) butoxide (15% (w/w; catalyst/reactants)), was used to catalyze the condensation of 0.05 mol glycerol with 0.10 mol of either succinic acid, glutaric acid, or azelaic acid to produce oligomers. The reactions were refluxed in dilute solutions of dimethylsulfoxide (DMSO) o...

431

The Lewis-acid-catalyzed synthesis of hyperbranched poly(glycerol-diacid)s in toluene  

Technology Transfer Automated Retrieval System (TEKTRAN)

The first examples of monomeric glycerol-derived hyperbranched polyesters produced in a non-polar solvent system are reported here. The polymers were made by the Lewis acid (dibutyltin(IV)oxide)-catalyzed polycondensation of glycerol with either succinic acid (n (aliphatic chain length)=2), glutari...

432

"Shutting up like a Telescope": Lewis Carroll's "Curious Condensation Method for Evaluating Determinants"  

ERIC Educational Resources Information Center

Charles Dodgson (Lewis Carroll) discovered a "curious" method for computing determinants. It is an iterative process that uses determinants of 2 x 2 submatrices of a matrix to obtain a smaller matrix. When the process ends, the result is the determinant of the original matrix. This article discusses both the algorithm and what may have led Dodgson…

Rice, Adrian; Torrence, Eve

2007-01-01

433

Prazosin, an alpha 1-adrenergic Receptor Antagonist, Suppresses Experimental Autoimmune Encephalomyelitis in the Lewis Rat  

Microsoft Academic Search

Prazosin, an antagonist of alpha 1-adrenergic receptors, has been found to suppress the clinical and histological expression of experimental autoimmune encephalomyelitis (EAE) in the Lewis rat. Suppression was more significant in females than in males and was a dose-dependent phenomenon. Analysis of the effect of other adrenergic receptor antagonists supports the conclusion that the suppressive effect of prazosin is a

Celia F. Brosnan; Ellen A. Goldmuntz; Wendy Cammer; Stephen M. Factor; Barry R. Bloom; William T. Norton

1985-01-01

434

Lewis acid catalysis of photochemical reactions. 7. Photodimerization and cross-cycloaddition of cinnamic esters  

SciTech Connect

The effects of Lewis acid complexation upon the molecular structure, solid-state photodimerization, and solution dimerization and cross-cycloaddition of cinnamic esters have been investigated. Comparison of crystal structures for free and SnCl/sub 4/-complexed ethyl cinnamate indicates that the enone double bonds are lengthened, the single bonds are shortened, and the enone conformation changes from s-cis to s-trans upon complexation. These changes are consistent with calculated changes in ..pi.. bonding and net charges. Solid-state photodimerization of free and complexed cinnamic esters and related molecules yield syn head-to-tail (..cap alpha..-truxillate) dimers. In most cases the Lewis acid complexes dimerize more efficiently and stereoselectively than the free esters. Photodimerization and cross-cycloaddition of methyl cinnamate in dilute solution is also catalyzed by Lewis acids. The mechanism of these reactions involves electronic excitation of a ground-state ester (dimerization) or simple olefin (cross cycloaddition). The catalytic effect of Lewis acids is attributed to an increase in excited-state lifetime and reactivity.

Lewis, F.D.; Quillen, S.L.; Hale, P.D.; Oxman, J.D.

1988-02-17

435

Autonomous Navigation of the SSTI\\/Lewis Spacecraft Using the Global Positioning System (GPS)  

Microsoft Academic Search

The National Aeronautics and Space Administration (NASA) Goddard Space Flight Center (GSFC) Flight Dynamics Division (FDD) is pursuing the application of Global Positioning System (GPS) technology to improve the accuracy and economy of spacecraft navigation. High-accuracy autonomous navigation algorithms are being flight qualified in conjunction with GSFC's GPS Attitude Determination Flyer (GADFLY) experiment on the Small Satellite Technology Initiative Lewis

R. C. Hart

436

Mapping and classification of Peatland on the Isle of Lewis using Landsat ETM+  

Microsoft Academic Search

Britain contains some of the largest areas of blanket peatland in the world and the monitoring of this resource is vital. This study has investigated whether Landsat ETM+ can be used to identify types of blanket peatland on Lewis. This was done using Principal Component Analysis (PCA) on composites of band ratios and single band variables, and using neural network

E. Brown; M. Aitkenhead; R. Wright; I. H. Aalders

2007-01-01

437

The relevance of the Lewy body to the pathogenesis of idiopathic Parkinson's disease  

Microsoft Academic Search

The Lewy body is a distinctive neuronal inclusion that is always found in the substantia nigra and other specific brain regions in Parkinson's disease. It is mainly composed of structurally altered neurofilament, and occurs wherever there is excessive loss of neurons. It occurs in some elderly individuals and rarely in other degenerative diseases of the central nervous system. In 273

W R Gibb; A J Lees

1988-01-01

438

Health Assessment for Centralia Landfill, Centralia, Lewis County, Washington, Region 10. CERCLIS No. WAD980936662.  

National Technical Information Service (NTIS)

The Centralia Landfill, an active landfill located on 80 acres of land in Centralia, Lewis County, Washington, has been proposed for addition to the National Priorities List. Wastes have been deposited on about 50 acres of the site. Historically, the land...

1990-01-01

439

Mild cognitive impairment associated with limbic and neocortical Lewy body disease: a clinicopathological study.  

PubMed

There are little data on the relationship between Lewy body disease and mild cognitive impairment syndromes. The Mayo Clinic aging and dementia databases in Rochester, Minnesota, and Jacksonville, Florida were queried for cases who were diagnosed with mild cognitive impairment between 1 January 1996 and 30 April 2008, were prospectively followed and were subsequently found to have autopsy-proven Lewy body disease. The presence of rapid eye movement sleep behaviour disorder was specifically assessed. Mild cognitive impairment subtypes were determined by clinical impression and neuropsychological profiles, based on prospective operational criteria. The diagnosis of clinically probable dementia with Lewy bodies was based on the 2005 McKeith criteria. Hippocampal volumes, rate of hippocampal atrophy, and proton magnetic resonance spectroscopy were assessed on available magnetic resonance imaging and spectroscopy scans. Eight subjects were identified; six were male. Seven developed dementia with Lewy bodies prior to death; one died characterized as mild cognitive impairment. The number of cases and median age of onset (range) for specific features were: seven with rapid eye movement sleep behaviour disorder-60 years (27-91 years), eight with cognitive symptoms-69 years (62-89 years), eight with mild cognitive impairment-70.5 years (66-91 years), eight with parkinsonism symptoms-71 years (66-92 years), six with visual hallucinations-72 years (64-90 years), seven with dementia-75 years (67-92 years), six with fluctuations in cognition and/or arousal-76 years (68-92 years) and eight dead-76 years (71-94 years). Rapid eye movement sleep behaviour disorder preceded cognitive symptom onset in six cases by a median of 10 years (2-47 years) and mild cognitive impairment diagnosis by a median of 12 years (3-48 years). The mild cognitive impairment subtypes represented include: two with single domain non-amnestic mild cognitive impairment, three with multi-domain non-amnestic mild cognitive impairment, and three with multi-domain amnestic mild cognitive impairment. The cognitive domains most frequently affected were attention and executive functioning, and visuospatial functioning. Hippocampal volumes and the rate of hippocampal atrophy were, on average, within the normal range in the three cases who underwent magnetic resonance imaging, and the choline/creatine ratio was elevated in the two cases who underwent proton magnetic resonance spectroscopy when they were diagnosed as mild cognitive impairment. On autopsy, six had neocortical-predominant Lewy body disease and two had limbic-predominant Lewy body disease; only one had coexisting high-likelihood Alzheimer's disease. These findings indicate that among Lewy body disease cases that pass through a mild cognitive impairment stage, any cognitive pattern or mild cognitive subtype is possible, with the attention/executive and visuospatial domains most frequently impaired. Hippocampal volume and proton magnetic resonance spectroscopy data were consistent with recent data in dementia with Lewy bodies. All cases with rapid eye movement sleep behaviour disorder and mild cognitive impairment were eventually shown to have autopsy-proven Lewy body disease, indicating that rapid eye movement sleep behaviour disorder plus mild cognitive impairment probably reflects brainstem and cerebral Lewy body disease. PMID:19889717

Molano, Jennifer; Boeve, Bradley; Ferman, Tanis; Smith, Glenn; Parisi, Joseph; Dickson, Dennis; Knopman, David; Graff-Radford, Neill; Geda, Yonas; Lucas, John; Kantarci, Kejal; Shiung, Maria; Jack, Clifford; Silber, Michael; Pankratz, V Shane; Petersen, Ronald

2009-11-04

440

DSM/Federal Energy Efficiency Partnership Program at Fort Lewis, Washington  

SciTech Connect

The Energy Systems Modernization Office at Pacific Northwest Laboratory is developing and applying the Federal Energy Decision Screening (FEDS) system for federal installations in cooperation with the servicing utility(s). In the process, we conduct an installation-wide, fuel-blind energy-efficiency resource assessment, identify the most life-cycle cost-effective technologies, work with the servicing utility to develop a program to implement energy conservation projects and technologies, evaluate rates and rate structures, and contribute to the design and implementation of an energy savings verification procedure to evaluate the impact of installed technologies. Fort Lewis was identified as a site for a pilot program which would result in a model approach to apply to other federal installations. Fort Lewis, a large (population 35,000) military installation in Tacoma, Washington, purchases electricity through Tacoma Public Utilities (TPU). TPU in turn purchases electricity through the Bonneville Power Administration. Fort Lewis has an annual electric load of about 195,000 megawatt-hours (MWh)({approximately}40 MW). An energy conservation supply curve for the Fort was developed showing the amount of electric energy savings that can be achieved at different prices for energy saved. From these data, a proposal was prepared for acquiring approximately 43,000 kilowatt-hours of annual cost-effective electric energy savings. This proposal identified investment requirements at the Fort and the likely energy and dollar savings which will result from the investment. Approximately $10 million of investment in electrical energy efficient end-use technology was estimated to be cost-effective at Fort Lewis under this arrangement. The result is that Fort Lewis will see a reduction in its electric bill of approximately $500,000/year.

Parker, G.B.; Secrest, T.J. [Pacific Northwest Lab., Richland, WA (United States); Flood, N. [Operations and Management Div., Fort Lewis, Washington (United States); Gillespie, A. [Army Forces Command, Atlanta, GA (United States)

1992-06-01

441

DSM/Federal Energy Efficiency Partnership Program at Fort Lewis, Washington. [Demand Side Management (DSM)  

SciTech Connect

The Energy Systems Modernization Office at Pacific Northwest Laboratory is developing and applying the Federal Energy Decision Screening (FEDS) system for federal installations in cooperation with the servicing utility(s). In the process, we conduct an installation-wide, fuel-blind energy-efficiency resource assessment, identify the most life-cycle cost-effective technologies, work with the servicing utility to develop a program to implement energy conservation projects and technologies, evaluate rates and rate structures, and contribute to the design and implementation of an energy savings verification procedure to evaluate the impact of installed technologies. Fort Lewis was identified as a site for a pilot program which would result in a model approach to apply to other federal installations. Fort Lewis, a large (population 35,000) military installation in Tacoma, Washington, purchases electricity through Tacoma Public Utilities (TPU). TPU in turn purchases electricity through the Bonneville Power Administration. Fort Lewis has an annual electric load of about 195,000 megawatt-hours (MWh)([approximately]40 MW). An energy conservation supply curve for the Fort was developed showing the amount of electric energy savings that can be achieved at different prices for energy saved. From these data, a proposal was prepared for acquiring approximately 43,000 kilowatt-hours of annual cost-effective electric energy savings. This proposal identified investment requirements at the Fort and the likely energy and dollar savings which will result from the investment. Approximately $10 million of investment in electrical energy efficient end-use technology was estimated to be cost-effective at Fort Lewis under this arrangement. The result is that Fort Lewis will see a reduction in its electric bill of approximately $500,000/year.

Parker, G.B.; Secrest, T.J. (Pacific Northwest Lab., Richland, WA (United States)); Flood, N. (Operations and Management Div., Fort Lewis, Washington (United States)); Gillespie, A. (Army Forces Command, Atlanta, GA (United States))

1992-06-01

442

Intra-neuronal vesicular uptake of catecholamines is decreased in patients with Lewy body diseases  

PubMed Central

Several neurodegenerative disorders, including Parkinson disease (PD), are characterized by the presence of Lewy bodies — cytoplasmic inclusions containing ?-synuclein protein aggregates — in the affected neurons. A poorly understood feature of Lewy body diseases is loss of sympathetic nerves in the heart and other organs, manifesting as orthostatic hypotension (OH; also known as postural hypotension). We asked whether sympathetic denervation is associated with decreased uptake of catecholamines, such as dopamine and norepinephrine, into storage vesicles within sympathetic neurons. We used 6-[18F]-dopamine (18F-DA) to track myocardial uptake and retention of catecholamines. Concurrently, the fate of intra-neuronal 18F-DA was followed by assessment of arterial plasma levels of the 18F-DA metabolite 18F-dihydroxyphenylacetic acid (18F-DOPAC). The ratio of myocardial 18F-DA to arterial 18F-DOPAC provided an index of vesicular uptake. Tracer concentrations were measured in patients with PD with or without orthostatic hypotension (PD+OH, PD-No-OH); in patients with pure autonomic failure (PAF, a Lewy body disease without parkinsonism); in patients with multiple system atrophy (MSA, a non–Lewy body synucleinopathy); and in normal controls. Patients with PD+OH or PAF had decreased vesicular 18F-DA uptake and accelerated 18F-DA loss, compared with MSA and control subjects. PD-No-OH patients could be subtyped into one of these categories based on their initial 18F-DA uptake. We conclude that sympathetic denervation in Lewy body diseases is associated with decreased vesicular uptake of neuronal catecholamines, suggesting that vesicular monoamine transport is impaired. Vesicular uptake may constitute a novel target for diagnosis, treatment, and prevention.

Goldstein, David S.; Holmes, Courtney; Kopin, Irwin J.; Sharabi, Yehonatan

2011-01-01

443

African Queens and Italian History: The Cultural Politics of Memory and Resistance in Teatro delle Albe’s Lunga vita all’albero and Gabriella Ghermandi’s Regina di fiori e di perle  

Microsoft Academic Search

This article discusses the emergence of a postcolonial Italian discourse through the analysis and comparison of two cultural productions belonging to two distinct historical periods. Lunga vita all’albero (Long Live the Tree, 1990) by the Ravenna-based interethnic company Teatro delle Albe is a play produced in the early stages of Senegalese immigration to Italy that imagines a shared history of

Clarissa Clò

2010-01-01

444

African Queens and Italian History: The Cultural Politics of Memory and Resistance in Teatro delle Albe’s Lunga vita all’albero and Gabriella Ghermandi’s Regina di fiori e di perle  

Microsoft Academic Search

: This article discusses the emergence of a postcolonial Italian discourse through the analysis and comparison of two cultural productions belonging to two distinct historical periods. Lunga vita all’albero (Long Live the Tree, 1990) by the Ravenna-based interethnic company Teatro delle Albe is a play produced in the early stages of Senegalese immigration to Italy that imagines a shared history

Clarissa Clò

2010-01-01

445

Relative preservation of MMSE scores in autopsy-proven dementia with Lewy bodies  

PubMed Central

Background: Recent studies raised questions about the severity of cognitive impairment associated with dementia with Lewy bodies (DLB). However, there have been few analyses of large, multicenter data registries for clinical–pathologic correlation. Methods: We evaluated data from the National Alzheimer's Coordinating Center registry (n = 5,813 cases meeting initial inclusion criteria) and the University of Kentucky Alzheimer's Disease Center autopsy series (n = 527) to compare quantitatively the severity of cognitive impairment associated with DLB pathology vs Alzheimer disease (AD) and AD+DLB pathologies. Results: Mini-Mental State Examination (MMSE) scores showed that persons with pure DLB had cognitive impairment of relatively moderate severity (final MMSE score 15.6 ± 8.7) compared to patients with pure AD and AD+DLB (final MMSE score 10.7 ± 8.6 and 10.6 ± 8.6). Persons with pure DLB pathology from both data sets had more years of formal education and were more likely to be male. Differences in final MMSE scores were significant (p < 0.01) between pure DLB and both AD+DLB and pure AD even after correction for education level, gender, and MMSE–death interval. Even in cases with extensive neocortical LBs, the degree of cognitive impairment was most strongly related to the amount of concomitant AD-type neurofibrillary pathology. Conclusions: Dementia with Lewy bodies can constitute a debilitating disease with associated psychiatric, motoric, and autonomic dysfunction. However, neocortical Lewy bodies are not a substrate for severe global cognitive impairment as assessed by the Mini-Mental State Examination. Instead, neocortical Lewy bodies appear to constitute or reflect an additive disease process, requiring Alzheimer disease or other concomitant brain diseases to induce severe global cognitive deterioration. GLOSSARY AD = Alzheimer disease; ADC = AD Center; CERAD = Consortium to Establish a Registry for Alzheimer's Disease; DLB = dementia with Lewy bodies; LBs = Lewy bodies; MMSE = Mini-Mental State Examination; NACC = National Alzheimer's Coordinating Center; NF = neurofibrillary; NIA-RI = National Institute of Aging-Reagan Institute; UK ADC = University of Kentucky Alzheimer's Disease Center.

Nelson, P T.; Kryscio, R J.; Jicha, G A.; Abner, E L.; Schmitt, F A.; Xu, L O.; Cooper, G; Smith, C D.; Markesbery, W R.

2009-01-01

446

A critical evaluation of current staging of alpha-synuclein pathology in Lewy body disorders.  

PubMed

The two most frequent synucleinopathies, Parkinson disease (PD) or brainstem predominant type of Lewy body disease, and dementia with Lewy bodies (DLB), are neurodegenerative multisystem disorders with widespread occurrence of alpha-synuclein containing deposits in the central, peripheral, and autonomic systems. For both Lewy body-related disorders staging/classification systems based on semiquantitative assessment of the distribution and progression pattern of alpha-synuclein pathology are used that are considered to be linked to clinical dysfunctions. In PD a six-stage system is suggested to indicate a predictable sequence of lesions with ascending progression from medullary and olfactory nuclei to the cortex, the first two presymptomatic stages related to incidental Lewy body disease, stages 3 and 4 presenting with motor symptoms and the last two (cortical) stages frequently associated with cognitive impairment. DLB, according to consensus pathologic guidelines, by semiquantitative scoring of alpha-synuclein pathology (Lewy body density and distribution) in specific brain regions, is distinguished into three phenotypes (brainstem, transitory/limbic and diffuse cortical), also considering concomitant Alzheimer-related pathology. Recent retrospective clinico-pathologic studies, although largely confirming the staging system, particularly for younger onset PD with long duration, have shown that between 6.3 and 43% of cases did not follow the proposed caudo-rostral progression pattern of alpha-synuclein pathology. In 7 to 8.3% of clinically manifested PD cases with synuclein inclusions in midbrain and cortex corresponding to LB stages 4-5 the medullary nuclei were spared, whereas mild parkinsonian symptoms were already observed in stages 2 and 3. There is considerable clinical and pathologic overlap between PD (with or without dementia) and DLB, corresponding to Braak LB stages 5 and 6, both frequently associated with variable Alzheimer-type pathology. Dementia often does not correlate with progressed stages of Lewy body pathology, but is related to concomitant Alzheimer lesions or mixed pathologies. There is no relationship between Braak LB stages and clinical severity of PD. Therefore, the predictive validity of this concept is doubtful, since in large unselected autopsy series 30 to 55% of elderly subjects with widespread alpha-synuclein pathology (Braak stages 5-6) revealed no definite neuropsychiatric symptoms or were not classifiable, indicating compensatory mechanisms of the brain. The causes and molecular basis of rather frequent deviations from the proposed caudo-rostral progression of alpha-synuclein pathology in PD, its relation to the onset of classical parkinsonian symptoms, the causes for the lack of definite clinical symptoms despite widespread alpha-synuclein pathology in the nervous system, their relations to Alzheimer-type lesions, and the pathophysiologic impact of both pathologies remain to be further elucidated. PMID:18718530

Jellinger, Kurt A

2008-08-05

447

In Situ Redox Manipulation of Subsurface Sediments from Fort Lewis, Washington: Iron Reduction and TCE Dechlorination Mechanisms  

SciTech Connect

The feasibility of chemically treating sediments from the Ft. Lewis, Washington, Logistics Center to develop a permeable barrier for dechlorination of TCE was investigated in a series of laboratory experiments.

Szecsody, James E.; Fruchter, Jonathan S.; Sklarew, Deborah S.; Evans, John C.

2000-03-17

448

A close association of torsinA and alpha-synuclein in Lewy bodies: a fluorescence resonance energy transfer study.  

PubMed

TorsinA, a novel protein in which a mutation causes dominant, early onset torsion dystonia, may serve as a chaperone for misfolded proteins that require refolding or degradation. It has been hypothesized that misfolded alpha-synuclein, a protein in which two mutations cause autosomal dominantly inherited Parkinson's disease, serves as a nidus for the development of a Lewy body. We hypothesized that torsinA plays a role in the cellular processing of alpha-synuclein. We demonstrate that anti-torsin antibodies stain Lewy bodies and Lewy neurites in the substantia nigra and cortex. Using sensitive fluorescent resonance energy transfer (FRET) techniques, we find evidence of a close association between torsinA and alpha-synuclein in Lewy bodies. PMID:11438481

Sharma, N; Hewett, J; Ozelius, L J; Ramesh, V; McLean, P J; Breakefield, X O; Hyman, B T

2001-07-01

449

Metal-ligand multiple bonds as frustrated Lewis pairs for C-H functionalization  

PubMed Central

Summary The concept of frustrated Lewis pairs (FLPs) has received considerable attention of late, and numerous reports have demonstrated the power of non- or weakly interacting Lewis acid–base pairs for the cooperative activation of small molecules. Although most studies have focused on the use of organic or main-group FLPs that utilize steric encumbrance to prevent adduct formation, a related strategy can be envisioned for both organic and inorganic complexes, in which "electronic frustration" engenders reactivity consistent with both nucleophilic (basic) and electrophilic (acidic) character. Here we propose that such a description is consistent with the behavior of many coordinatively unsaturated transition-metal species featuring metal–ligand multiple bonds, and we further demonstrate that the resultant reactivity may be a powerful tool for the functionalization of C–H and E–H bonds.

2012-01-01

450

Gallium-containing polymer brush film as efficient supported Lewis acid catalyst in a glass microreactor.  

PubMed

Polystyrene sulfonate polymer brushes, grown on the interior of the microchannels in a microreactor, have been used for the anchoring of gallium as a Lewis acid catalyst. Initially, gallium-containing polymer brushes were grown on a flat silicon oxide surface and were characterized by FTIR, ellipsometry, and X-ray photoelectron spectroscopy (XPS). XPS revealed the presence of one gallium per 2-3 styrene sulfonate groups of the polymer brushes. The catalytic activity of the Lewis acid-functionalized brushes in a microreactor was demonstrated for the dehydration of oximes, using cinnamaldehyde oxime as a model substrate, and for the formation of oxazoles by ring closure of ortho-hydroxy oximes. The catalytic activity of the microreactor could be maintained by periodic reactivation by treatment with GaCl3. PMID:24062830

Munirathinam, Rajesh; Ricciardi, Roberto; Egberink, Richard J M; Huskens, Jurriaan; Holtkamp, Michael; Wormeester, Herbert; Karst, Uwe; Verboom, Willem

2013-08-16

451

Elk Monitoring Protocol for Lewis and Clark National Historical Park, Version 1.0  

USGS Publications Warehouse

Maintaining elk (Cervus elaphus roosevelti) herds that frequent Lewis and Clark National Historical Park (NHP) is central to the park’s purpose of preserving the historic, cultural, scenic, and natural resources. Elk were critical to sustaining the members of the Lewis and Clark expedition by providing food and clothing over the winter of 1805-1806. Today, elk viewing opportunities in the park and surrounding region generate broad appeal with the visiting public, which number over 250,000 per year at the Fort Clatsop visitor center. This protocol describes procedures for monitoring trends in the use of the Fort Clatsop area by Roosevelt elk. Specific objectives of elk monitoring in Lewis and Clark NHP are to measure the relative use and proportion of area used by elk during winter in the Fort Clatsop Unit of the park, and the rate at which elk are sighted from roads in and around the park. Relative use and the proportion of area used by elk are determined from elk fecal pellet surveys conducted every other year in the Fort Clatsop park unit. Pairs of observers visit a systematic array of permanent plots in the fall to clear them of elk fecal pellets, and return to the plots in late winter to count elk fecal pellets that have accumulated during winter. Half of the subplots are counted by two independent observers, which allows for the estimation of relative use and proportion of area occupied by elk with analyses of detection biases that account for unseen elk pellet groups. Standardized road surveys are conducted in and near the Fort Clatsop park unit three or four times monthly during alternate months. Data from road surveys are used to quantify the rate that park visitors would be expected to see elk, when driving the selected set of routes. The monitoring protocol is based on three field seasons of development and testing. The protocol narrative describes the background, rationale, sampling design, field methods, analytical methods, data management, reporting, personnel requirements, and operational requirements for elk monitoring in Lewis and Clark NHP. The sampling design reflects tradeoffs between statistical and ecological considerations, safety, and current budget considerations. The protocol provides adequate power to detect a doubling or halving of elk use in the Fort Clatsop unit and surrounding areas within 15 years. Step-by-step guidance for planning and completing the monitoring tasks are in the attached standard operating procedures (SOPs). Information on the status and trends of elk use in Lewis and Clark NHP will allow park managers to assess the effects on elk of restoration programs within the park, build community partnerships, and identify potential linkages between regional land use changes and elk use of the Park. Lewis and Clark NHP has an active ecological restoration program that aims to recreate, where possible, ecological conditions that Lewis and Clark encountered. The restoration program includes an extensive exotic plant removal program, wetland restoration, and silvicultural treatments that will hasten development of late-seral conditions in recently acquired forest lands of the Fort Clatsop park unit. In the future, monitoring results can be used to test for spatial associations between ecological restoration treatments and relative use by elk. The park also plans to feature results from elk monitoring prominently in its educational outreach activities to help interpret the historical and current ecological context of the Lewis and Clark story, and engender public support for the park mission and management activities. Although NPS does not manage non-park lands, information about trends in the distribution of elk use will be valuable in public outreach and discussions with other partnering agencies and regional private landowners.

Kurt J Jenkins;Paul Griffin;John R. Boetsch;Carla Cole

2011-01-01

452

Samuel A Levine's first world war encounters with Mackenzie and Lewis.  

PubMed Central

Samuel Albert Levine was a key figure in modern cardiology in the United States. During the first world war he was one of a select group of United States medical officers assigned to the British Military Heart Hospital where he encountered the "British medical giants"--Clifford Allbutt, William Osler, James Mackenzie, and Thomas Lewis. Levine's diary, written when he was a young medical officer during the first world war, presents crisp character sketches of James Mackenzie and Thomas Lewis. The autobiographical vignettes he wrote later in life were more gracious and polished retrospectives. The Levine perspectives, separated by a half century, contribute to our understanding of the developing fabric of Anglo-American cardiology. Images

Wooley, C F; Stang, J M

1990-01-01

453

An early manuscript in the history of American comparative psychology: Lewis Henry Morgan's "Animal Psychology" (1857).  

PubMed

Lewis Henry Morgan (1818-1881) is best known as the 1st ethnographer of Native American culture, but he also wrote on animal psychology, beginning in 1843, some 50 years before the founding of comparative psychology as a scientific discipline. Although not an evolutionist, Morgan argued that animals possess many human mental abilities, such as reason and moral judgment, and he rejected the scientific utility of the concept of instinct, a view that did not gain much currency in psychology until the rise of behaviorism in the 1920s. This 1857 manuscript, which is in the Lewis Henry Morgan Papers at the University of Rochester in Rochester, New York, formed the basis for the last chapter of his 1868 monograph on the American beaver but gives additional information on his sources and an expanded criticism of the concept of instinct. PMID:12465615

Johnston, Timothy D

2002-11-01

454

Evolution of Brönsted and Lewis acidity of single and mixed pillared bentonite  

NASA Astrophysics Data System (ADS)

The surface acidity of different pillared clay, zirconium-, aluminium- and mixed zirconium-aluminium-pillared bentonite was determined by Fourier transform infrared spectroscopy technique using N-butylamine as probe molecule. The spectra obtained showed well resolved absorption bands for Lewis and Brönsted acid sites in the clay catalysts. In order to understand the role of acid sites present on clay catalysts, synthesis of 2,2-dimethyl-1,3-dioxolane by acetalyzation of acetone with ethylene glycol under autogenous pressure and without solvent has been studied. The Brönsted and Lewis acidity data obtained by FT-IR study for modified bentonite correlated well with the catalytic activity in the synthesis of 2,2-dimethyl-1,3-dioxolane reaction. Among the modified clay catalysts, Zr90-Al10-PILC bentonite catalysts showed good activity and aluminium rich PILC showed negligible activity in the acetalyzation reaction. This inactivity is attributed to the absence of Brönsted acidity.

Mnasri, S.; Frini-Srasra, N.

2013-05-01

455

Modeling the mass balance of tropical Lewis Glacier, Mt Kenya, and its sensitivity to climate  

NASA Astrophysics Data System (ADS)

Meteorological and glaciological measurements on Lewis Glacier, Mt Kenya, (0.15° S, 37.30° E) are used to run a physically-based mass balance model for the two years period September 2009 to September 2011. Data for input, optimization and validation are provided by an automatic weather station (~4830 m) installed on the glacier and a network of ablation stakes. On a local scale, sensitivity studies allow the detection of the main drivers of the energy balance of the glacier surface. A focus is put on energy fluxes governed by the seasonal fluctuations of moisture (wet / dry seasons). On a more regional scale, decoding the local glacier-atmosphere interaction is crucial to understand the regional climate forcing which provides the basis to explain the rapid retreat of Lewis Glacier observed over almost a century.

Prinz, R.; Moelg, T.; Nicholson, L.; Kaser, G.

2011-12-01

456

Large scale climatological controls of the mass balance of tropical Lewis Glacier, Mt Kenya, East Africa  

NASA Astrophysics Data System (ADS)

Among other effects on the mass and energy balance, tropical glaciers are particularly sensitive to precipitation, which increases both mass accumulation and albedo (and thus reduces ablation). Therefore, precipitation variability is directly linked to mass balance variability. Multi-year and inter-annual fluctuations in large scale climate patterns (IOZM, ENSO) are known to strongly correlate with precipitation variability in equatorial East Africa, but little is known about how this effects the precipitation at high elevations on Mt Kenya. In this study we compare (i) the mass balance time series of Lewis Glacier, Mt Kenya (1978 - 1996) and (ii) high altitude precipitation measurements from the mountain to gridded regional climate data and multi-year climate oscillations. These regional influences, superimposed on the overarching tropical climate conditions and seasonality, play a key role for seasons with abundant snowfall on the glacier and, in combination with radiative forcing, explain the predominantly negative mass balances on Lewis glacier.

Prinz, Rainer; Nicholson, Lindsey; Mölg, Thomas; Marzeion, Ben; Kaser, Georg

2010-05-01

457

Applied high-speed imaging for the icing research program at NASA Lewis Research Center  

NASA Astrophysics Data System (ADS)

The Icing Research Tunnel at NASA Lewis Research Center provides scientists a scaled, controlled environment to simulate natural icing events. The closed-loop, low speed, refrigerated wind tunnel offers the experimental capability to test for icing certification requirements, analytical model validation and calibration techniques, cloud physics instrumentation refinement, advanced ice protection systems, and rotorcraft icing methodology development. The test procedures for these objectives all require a high degree of visual documentation, both in real-time data acquisition and post-test image processing. Information is provided to scientific, technical, and industrial imaging specialists as well as to research personnel about the high-speed and conventional imaging systems will be on the recent ice protection technology program. Various imaging examples for some of the tests are presented. Additional imaging examples are available from the NASA Lewis Research Center's Photographic and Printing Branch.

Slater, Howard; Owens, Jay; Shin, Jaiwon

458

Applied high-speed imaging for the icing research program at NASA Lewis Research Center  

NASA Astrophysics Data System (ADS)

The Icing Research Tunnel at NASA Lewis Research Center provides scientists a scaled, controlled environment to simulate natural icing events. The closed-loop, low speed, refrigerated wind tunnel offers the experimental capability to test for icing certification requirements, analytical model validation and calibration techniques, cloud physics instrumentation refinement, advanced ice protection systems, and rotorcraft icing methodology development. The test procedures for these objectives all require a high degree of visual documentation, both in real-time data acquisition and post-test image processing. Information is provided to scientific, technical, and industrial imaging specialists as well as to research personnel about the high-speed and conventional imaging systems will be on the recent ice protection technology program. Various imaging examples for some of the tests are presented. Additional imaging examples are available from the NASA Lewis Research Center's Photographic and Printing Branch.

Slater, Howard; Owens, Jay; Shin, Jaiwon

1992-01-01

459

Novel Ionic Liquid with Both Lewis and Br?nsted Acid Sites for Michael Addition  

PubMed Central

Ionic liquid with both Lewis and Brønsted acid sites has been synthesized and its catalytic activities for Michael addition were carefully studied. The novel ionic liquid was stable to water and could be used in aqueous solution. The molar ratio of the Lewis and Brønsted acid sites could be adjusted to match different reactions. The results showed that the novel ionic liquid was very efficient for Michael addition with good to excellent yields within several min. Operational simplicity, high stability to water and air, small amount used, low cost of the catalyst used, high yields, chemoselectivity, applicability to large-scale reactions and reusability are the key features of this methodology, which indicated that this novel ionic liquid also holds great potential for environmentally friendly processes.

Jiang, Xiaoyue; Ye, Weidong; Song, Xiaohua; Ma, Wenxin; Lao, Xuejun; Shen, Runpu

2011-01-01

460

Cooperative Catalysis by Carbenes and Lewis Acids in a Highly Stereoselective Route to ?-Lactams  

PubMed Central

Enzymes are a continuing source of inspiration for the design of new chemical reactions that proceed with efficiency, high selectivity and minimal waste. In many biochemical processes, different catalytic species, such as Lewis acids and bases, are involved in precisely orchestrated interactions to activate reactants simultaneously or sequentially. Employing this type of cooperative catalysis, in which two or more catalytic cycles operate concurrently to achieve one overall transformation, has great potential to enhance known reactivity and drive the development of new chemical reactions with high value. In this disclosure, a cooperative N-heterocyclic carbene/Lewis acid catalytic system promotes the addition of homoenolate equivalents to hydrazones generating highly substituted ?-lactams in moderate to good yields and high levels of diastereo- and enantioselectivity.

Raup, Dustin E. A.; Cardinal-David, Benoit; Holte, Dane; Scheidt, Karl A.

2010-01-01

461

Gallium-containing polymer brush film as efficient supported Lewis acid catalyst in a glass microreactor  

PubMed Central

Summary Polystyrene sulfonate polymer brushes, grown on the interior of the microchannels in a microreactor, have been used for the anchoring of gallium as a Lewis acid catalyst. Initially, gallium-containing polymer brushes were grown on a flat silicon oxide surface and were characterized by FTIR, ellipsometry, and X-ray photoelectron spectroscopy (XPS). XPS revealed the presence of one gallium per 2–3 styrene sulfonate groups of the polymer brushes. The catalytic activity of the Lewis acid-functionalized brushes in a microreactor was demonstrated for the dehydration of oximes, using cinnamaldehyde oxime as a model substrate, and for the formation of oxazoles by ring closure of ortho-hydroxy oximes. The catalytic activity of the microreactor could be maintained by periodic reactivation by treatment with GaCl3.

Munirathinam, Rajesh; Ricciardi, Roberto; Egberink, Richard J M; Huskens, Jurriaan; Holtkamp, Michael; Wormeester, Herbert; Karst, Uwe

2013-01-01

462

Lewis base-catalyzed conjugate reduction and reductive aldol reaction of alpha,beta-unsaturated ketones using trichlorosilane.  

PubMed

Lewis bases such as Ph3P=O and HMPA catalyze the 1,4-reduction of alpha,beta-unsaturated ketones with trichlorosilane, and because the 1,2-reduction of aldehydes scarcely proceeded under the conditions, one-pot reductive aldol reactions with aldehydes were successfully achieved; preliminary studies using a chiral Lewis base revealed a high potential for enantioselective catalysis. PMID:18802553

Sugiura, Masaharu; Sato, Norimasa; Kotani, Shunsuke; Nakajima, Makoto

2008-07-17

463

Hydride affinities of borane derivatives: novel approach in determining the origin of lewis acidity based on triadic formula.  

PubMed

The problem of intrinsic Lewis acidities of simple boron compounds (BH3-mXm, m = 0-3, X = F, Cl, Br, CH3, and OH) is assessed by their gas-phase hydride affinities (HAs). A simple and intuitively appealing picture of the interaction process including detachment of an electron from the hydride ion H-, capture of the pruned electron to the investigated Lewis acid (LA), and subsequent formation of the homolytic chemical bond between two newly created radicals is proposed. It enables transparent and straightforward dissection of the initial and final state effects, which taken together with the intermediate relaxation stabilization determine the trend of changes in the hydride affinities. The former effect is reflected in the electron affinities of the neutral Lewis acids given within Koopmans' approximation, while the final state effect involves properties of the formed Lewis acid-base adducts mirrored in the bond dissociation energy of the formed [LA-H]- chemical bond. It is demonstrated that unexpectedly low Lewis acidity of fluoroboranes relative to the corresponding chlorine and bromine derivatives can be traced down to the unfavorable Koopmans' electron affinities. Hence, it is a consequence of the initial state effect. In contrast, chloroboranes are more potent Lewis acids than fluoroboranes, because the relaxation and final state effects decisively influence their Lewis acidity. Finally, bromine-substituted borane compounds provide the most powerful studied Lewis acids. Their hydride affinities are result of a synergic interplay of the initial state, intermediate stabilization via relaxation, and final state effects. It is shown that Pearson's global hardness indices defined within his hard and soft acid-base (HSAB) principle fail to adequately predict and interpret the calculated hydride affinities. PMID:15859291

Vianello, Robert; Maksi?, Zvonimir B

2005-02-21

464

Behavioral sensitization to amphetamine follows chronic administration of the CB 1 agonist WIN 55,212-2 in Lewis rats  

Microsoft Academic Search

The extent to which acute and repeated administration of the CB1 agonist WIN 55,212-2 would affect the stimulatory properties of amphetamine was assessed in Lewis rats. In the first experiment, Lewis rats were treated with either 1 mg\\/kg of WIN 55,212-2 or vehicle and subsequently treated with 2 mg\\/kg amphetamine. Acute treatment with WIN 55,212-2 initially increased locomotor activity and

John W Muschamp; Stephen M Siviy

2002-01-01

465

Detection and isolation of dendritic cells using Lewis X-functionalized magnetic nanoparticles.  

PubMed

dendritic cell (DC)-specific intracellular adhesion molecule-3 grabbing nonintegrin (DC-SIGN) is a receptor found on DCs that recognizes antigens bearing mannose-rich or fucosylated glycans, including Lewis X (Le(X)). Here, we report the fabrication of magnetic nanoparticles coated with multivalent Le(X) glycans using Cu (I)-catalyzed azide-alkyne cycloaddition. The resulting nanoparticles are selective and biocompatible, serving as a highly efficient tool for DC detection and enrichment. PMID:22901307

Rouhanifard, Sara H; Xie, Ran; Zhang, Guoxin; Sun, Xiaoming; Chen, Xing; Wu, Peng

2012-09-11

466

Detection and Isolation of Dendritic Cells Using Lewis X-functionalized Magnetic Nanoparticles  

PubMed Central

DC-specific intracellular adhesion molecule-3 grabbing non-integrin (DC-SIGN) is a receptor found on dendritic cells (DCs) that recognizes antigens bearing mannose-rich or fucosylated glycans, including Lewis X (LeX). Here, we report the fabrication of magnetic nanoparticles coated with multivalent LeX glycans using the Cu (I)-catalyzed azide-alkyne cycloaddition. The resulting nanoparticles are selective and biocompatible, serving as a highly efficient tool for DC detection and enrichment.

Rouhanifard, Sara H.; Xie, Ran; Zhang, Guoxin; Sun, Xiaoming; Chen, Xing; Wu, Peng

2012-01-01

467

Meloxicam: A potent inhibitor of adjuvant arthritis in the Lewis rat  

Microsoft Academic Search

The effects of meloxicam, piroxicam, diclofenac and tenidap on the swelling of hind paws, radiologically-detectable bone and cartilage destruction of hind paws, increase in spleen weight, increase in erythrocyte sedimentation rate and changes in serum protein composition in male Lewis rats with adjuvant arthritis were studied following once-daily oral administration of these drugs for 21 days. All the drugs dose-dependently

G. Engelhardt; D. Homma; C. Schnitzler

1995-01-01

468

Applied analytical combustion/emissions research at the NASA Lewis Research Center  

NASA Astrophysics Data System (ADS)

Emissions of pollutants from future commercial transports are a significant concern. As a result, the Lewis Research Center (LeRC) is investigating various low emission combustor technologies. As part of this effort, a combustor analysis code development program was pursued to guide the combustor design process, to identify concepts having the greatest promise, and to optimize them at the lowest cost in the minimum time.

Deur, J. M.; Kundu, K. P.; Nguyen, H. L.

1992-07-01

469

A Volumetric Magnetic Resonance Imaging Study of Entorhinal Cortex Volume in Dementia with Lewy Bodies  

Microsoft Academic Search

Aims: To investigate whether subjects with dementia with Lewy bodies (DLB), Alzheimer’s disease (AD) and Parkinson’s disease with dementia (PDD) have reduced entorhinal cortex (EC) volumes compared to controls and cognitively intact Parkinson’s disease (PD) subjects. Methods: Volumes of the EC were measured on magnetic resonance imaging (MRI) scans of 144 individuals (aged over 65 years): 20 with DLB, 26

Eva R. Kenny; Emma J. Burton; John T. O’Brien

2008-01-01

470

Association between male gender and cortical Lewy body pathology in large autopsy series  

Microsoft Academic Search

Sex-linked factors may alter risk for neurodegenerative diseases. Definitive diagnoses are not established until autopsy,\\u000a so neuropathological studies are critical. There have not been reported gender-related differences in neocortical Lewy bodies\\u000a (LBs) using large multi-center autopsy series. We evaluated the associations between gender and pathologically characterized\\u000a neurodegenerative diseases. Cases with Alzheimer’s disease (AD), neocortical LBs, AD + neocortical LBs, or neither pathology

Peter T. Nelson; Frederick A. Schmitt; Gregory A. Jicha; Richard J. Kryscio; Erin L. Abner; Charles D. Smith; Linda J. Van Eldik; William R. Markesbery

2010-01-01

471

Overview of NASA Lewis Research Center free-piston Stirling engine activities  

Microsoft Academic Search

An overview of the National Aeronautics and Space Administration (NASA) Lewis Research Center (LeRC) free-piston Stirling engine activities is presented. These include (1) a generic free-piston Stirling technology project being conducted to develop technologies generic to both space power and terrestrial heat pump applications in a cooperative, costshared effort with the Department of Energy (DOE)\\/Oak Ridge National Laboratory (ORNL); and

Jack G. Slaby

1984-01-01

472

Lewis acid mediated diastereoselective synthesis of fused fluorinated spiroketal as potential biologically active compounds  

Microsoft Academic Search

A series of substituted dibenzalacetones prepared using standard procedures were condensed with 5-methyl, 5-phenyl, and 5-trifluoromethyl-1,3-cyclohexanediones respectively, in toluene containing BF3·OEt as the Lewis acid catalyst. The reaction was found to be highly diastereoselective (dr, 9:1). The resulting spiroketals 1a–r were formed in moderate to good yields. In addition, a synthetically and biologically useful by-product identified as chromenone 7 was

Oluropo C. Agbaje; Olugbeminiyi O. Fadeyi; Cosmas O. Okoro

2011-01-01

473

Serum and Cerebrospinal Fluid Levels of Transthyretin in Lewy Body Disorders with and without Dementia  

PubMed Central

Parkinson’s disease (PD) without (non-demented, PDND) and with dementia (PDD), and dementia with Lewy bodies (DLB) are subsumed under the umbrella term Lewy body disorders (LBD). The main component of the underlying pathologic substrate, i.e. Lewy bodies and Lewy neurites, is misfolded alpha-synuclein (Asyn), and - in particular in demented LBD patients - co-occurring misfolded amyloid-beta (Abeta). Lowered blood and cerebrospinal fluid (CSF) levels of transthyretin (TTR) - a clearance protein mainly produced in the liver and, autonomously, in the choroid plexus - are associated with Abeta accumulation in Alzheimer’s disease. In addition, a recent study suggests that TTR is involved in Asyn clearance. We measured TTR protein levels in serum and cerebrospinal fluid of 131 LBD patients (77 PDND, 26 PDD, and 28 DLB) and 72 controls, and compared TTR levels with demographic and clinical data as well as neurodegenerative markers in the CSF. Five single nucleotide polymorphisms of the TTR gene which are considered to influence the ability of the protein to carry its ligands were also analyzed. CSF TTR levels were significantly higher in LBD patients compared to controls. Post-hoc analysis demonstrated that this effect was driven by PDND patients. In addition, CSF TTR levels correlated negatively with CSF Abeta1–42, total tau and phospho-tau levels. Serum TTR levels did not significantly differ among the studied groups. There were no relevant associations between TTR levels and genetic, demographic and clinical data, respectively. These results suggest an involvement of the clearance protein TTR in LBD pathophysiology, and should motivate to elucidate TTR-related mechanisms in LBD in more detail.

Gauger, Tina; Odoj, Bartholomaus; Schmid, Benjamin; Schulte, Claudia; Deuschle, Christian; Heck, Susanna; Apel, Anja; Melms, Arthur; Gasser, Thomas; Berg, Daniela

2012-01-01

474

Striatal ?-amyloid in dementia with Lewy bodies but not Parkinson’s disease  

Microsoft Academic Search

Professor Jellinger first identified that striatal A? deposition at postmortem seemed to differentiate cases of dementia with\\u000a Lewy bodies (DLB) from those with Parkinson’s disease dementia (PDD), a finding subsequently questioned. Our replication study\\u000a in 34 prospectively studied cases assessed the ability of striatal A? deposition to differentiate DLB from PDD, and also assessed\\u000a the relationship between striatal and cortical

Glenda M. HallidayYun; Yun Ju C. Song; Antony J. Harding

2011-01-01

475

Phosphino-boryl-naphthalenes: geometrically enforced, yet Lewis acid responsive P ? B interactions.  

PubMed

Three naphthyl-bridged phosphine-borane derivatives 2-BCy2, 2-BMes2, and 2-BFlu, differing in the steric and electronic properties of the boryl moiety, have been prepared and characterized by spectroscopic and crystallographic means. The presence and magnitude of the P ? B interactions have been assessed experimentally and theoretically. The naphthyl linker was found to enforce the P ? B interaction despite steric shielding, while retaining enough flexibility to respond to the Lewis acidity of boron. PMID:23544869

Bontemps, Sébastien; Devillard, Marc; Mallet-Ladeira, Sonia; Bouhadir, Ghenwa; Miqueu, Karinne; Bourissou, Didier

2013-04-01

476

Myocardial 123I-MIBG scintigraphy for differentiation of Lewy bodies disease from FTD  

Microsoft Academic Search

Clinical distinction between Lewy bodies disease (LBD) and frontotemporal dementia (FTD) is sometimes difficult. Nigrostriatal dopaminergic degeneration occurs in both LBD and FTD, limiting helpfulness of DAT imaging to differentiate these forms of dementia. Several studies have emphasized the usefulness of myocardial scintigraphy with 123Metaiodobenzylguanidine (123I-MIGB) in assessing the sympathetic nerve terminals in LBD demonstrating that cardiac 123I-MIGB uptake is

Fabiana Novellino; Antonio Bagnato; Maria Salsone; Giuseppe Lucio Cascini; Giuseppe Nicoletti; Gennarina Arabia; Pierfrancesco Pugliese; Maurizio Morelli; Sandra Paglionico; Stefania Cipullo; Ida Manna; Elvira Valeria De Marco; Francesca Condino; Carmelina Chiriaco; Letterio Morgante; Mario Zappia; Aldo Quattrone

2010-01-01

477

Phosphorylated TDP43 in Alzheimer’s disease and dementia with Lewy bodies  

Microsoft Academic Search

Phosphorylated and proteolytically cleaved TDP-43 is a major component of the ubiquitin-positive inclusions in the most common\\u000a pathological subtype of frontotemporal lobar degeneration (FTLD-U). Intracellular accumulation of TDP-43 is observed in a\\u000a subpopulation of patients with other dementia disorders, including Alzheimer’s disease (AD) and dementia with Lewy bodies\\u000a (DLB). However, the pathological significance of TDP-43 pathology in these disorders is

Tetsuaki Arai; Ian R. A. Mackenzie; Masato Hasegawa; Takashi Nonoka; Kazhuhiro Niizato; Kuniaki Tsuchiya; Shuji Iritani; Mitsumoto Onaya; Haruhiko Akiyama

2009-01-01

478

Suppression of chronic streptococcal cell wall-induced arthritis in Lewis rats by liposomal clodronate  

Microsoft Academic Search

Objectives. To investigate the role of macrophages in the pathogenesis of chronic streptococcal cell wall (SCW)-induced arthritis using liposomal clodronate. Methods. Female Lewis rats with SCW-induced arthritis received a single intravenous injection of 20 mg of clodronate encapsulated within small unilamellar vesicles (SUVc) 10 days post-arthritis induction. Results. SUVc significantly suppressed the development of chronic SCW-induced arthritis for up to

P. J. Richards; B. D. Williams; A. S. Williams

2001-01-01

479

Lewis base assisted B-H bond redistribution in borazine and polyborazylene.  

PubMed

Lewis bases react with borazine and polyborazylene, yielding borane adducts. In the case of NH3 (l), ammonia-borane (AB) is formed and quantified using NMR spectroscopy against an internal standard. Calculations indicate that the formation of B(NH2)3 may provide the driving force of this redistribution. Given the complexity and expense of currently known spent AB regeneration pathways, it is suggested that this redistribution chemistry be used to recover AB and improve regeneration methods. PMID:23963199

Davis, Benjamin L; Rekken, Brian D; Michalczyk, Ryszard; Garner Iii, Edward B; Dixon, David A; Kalviri, Hassan; Baker, R Tom; Thorn, David L

2013-08-21

480

Effects of Lewis acid-type transition metal chloride additives on the thermal degradation of ABS  

Microsoft Academic Search

The thermal degradation of ABS in the presence of Lewis acid-type transition metal chloride additives has been studied by thermogravimetric analysis. The reaction of transition metal chlorides (NiCl2, CoCl2, ZnCl2 and FeCl3) and ABS has been found to occur during the thermal degradation of ABS. In an inert atmosphere, char formation is observed, and some 10–30% of the reaction product

Junwon Jang; Jinhwan Kim; Jin-Young Bae

2005-01-01

481

Controlled accessibility Lewis acid catalysed thermal reactions of regenerated cellulosic fibres  

Microsoft Academic Search

A combination of techniques have been used to characterise lyocell regenerated cellulose fibre subjected to low-moisture thermal-catalytic\\u000a reactions with zinc chloride Lewis acid. Application from non-swelling ethanol reduces catalyst accessibility, but at high\\u000a temperatures migration takes place through the internal fibre morphology. The extent of chain scission is reduced at lower\\u000a temperatures, leading to a higher leveling-off degree of polymerisation

Dimtra Domvoglou; Franz Wortmann; Jim Taylor; Roger Ibbett

2010-01-01

482

Hematopoiesis and Suppressor Bone Marrow Cells in Mice Bearing Large Metastatic Lewis Lung Carcinoma Tumors1  

Microsoft Academic Search

Mice bearing a metastatic variant of Lewis lung carcinoma (LLC-C3) were studied to determine if there might be a relationship between tumor induced hematopoiesis and immune suppression. Growth of LLC-C3 in C57BL\\/6 mice corresponded with increased hematopoiesis and an in crease in the proportion of monocytes in the peripheral blood, spleen, and bone marrow. The LLC-C3 cells secreted colony stimulating

M. Rita Young; Marilyn Newby; H. Terry Wepsic

483

Cognitive Profiles of Autopsy-Confirmed Lewy Body Variant vs Pure Alzheimer Disease  

Microsoft Academic Search

Objective: To compare the cognitive profiles of pa- tients with autopsy-confirmed Alzheimer disease (AD), with or without concomitant Lewy bodies, on 2 demen- tia screening measures. Methods: Profiles on subtests of the Mattis Dementia Rating Scale (range, 105-125) and of component items of the Mini-Mental State Examination were compared be- tween 23 patients with uncomplicated AD and 23 pa- tients

Donald J. Connor; David P. Salmon; Teresa J. Sandy; Douglas Galasko; Lawrence A. Hansen; Leon J. Thal

1998-01-01

484

Duplex development and abandonment during evolution of the Lewis thrust system, southern Glacier National Park, Montana  

NASA Astrophysics Data System (ADS)

Geologic mapping in southern Glacier National Park, Montana, reveals the presence of two duplexes sharing the same floor thrust fault, the Lewis thrust. The westernmost duplex (Brave Dog Mountain) includes the low-angle Brave Dog roof fault and Elk Mountain imbricate system, and the easternmost (Rising Wolf Mountain) duplex includes the low-angle Rockwell roof fault and Mt. Henry imbricate system. The geometry of these duplexes suggests that they differ from previously described geometric-kinematic models for duplex development. Their low-angle roof faults were preexisting structures that were locally utilized as roof faults during the formation of the imbricate systems. Crosscutting of the Brave Dog fault by the Mt. Henry imbricate system indicates that the two duplexes formed at different times. The younger Rockwell-Mt. Henry duplex developed 20 km east of the older Brave Dog-Elk Mountain duplex; the roof fault of the former is at a higher structural level. Field relations confirm that the low-angle Rockwell fault existed across the southern Glacier Park area prior to localized formation of the Mt. Henry imbricate thrusts beneath it. These thrusts kinematically link the Rockwell and Lewis faults and may be analogous to P shears that form between two synchronously active faults bounding a simple shear system. The abandonment of one duplex and its replacement by another with a new and higher roof fault may have been caused by (1) warping of the older and lower Brave Dog roof fault during the formation of the imbricate system (Elk Mountain) beneath it, (2) an upward shifting of the highest level of a simple shear system in the Lewis plate to a new decollement level in subhorizontal belt strata (= the Rockwell fault) that lay above inclined strata within the first duplex, and (3) a reinitiation of P-shear development (= Mt. Henry imbricate faults) between the Lewis thrust and the subparallel, synkinematic Rockwell fault.

Yin, An; Kelty, Thomas K.; Davis, Gregory A.

1989-09-01

485

Lewis acid–base complexation of polyamide 66 to control hydrogen bonding, extensibility and crystallinity  

Microsoft Academic Search

Polyamide 66 (PA66) has been complexed with the Lewis acid GaCl3 for the purpose of disrupting the interchain hydrogen bonded network. FTIR and 13C-NMR observations indicate that Ga metal cations form a 1:1 complex with the carbonyl oxygens of the PA66 amide groups. PA66–GaCl3 films are amorphous and rubbery with a single relaxation, attributable to the glass transition temperature, at

Nadarajah Vasanthan; Richard Kotek; Dong-Wook Jung; Daniel Shin; Alan E Tonelli; David R Salem

2004-01-01

486

Energy efficiency campaign for residential housing at the Fort Lewis army installation  

SciTech Connect

In FY1999, Pacific Northwest National Laboratory conducted an energy efficiency campaign for residential housing at the Fort Lewis Army Installation near Tacoma, Washington. Preliminary weather-corrected calculations show energy savings of 10{percent} from FY98 for energy use in family housing. This exceeded the project's goal of 3{percent}. The work was funded by the U.S. DOEs Federal Energy Management Program (FEMP), Office of Energy Efficiency and Renewable Energy. The project adapted FEMP's national ``You Have the Power Campaign'' at the local level, tailoring it to the military culture. The applied research project was designed to demonstrate the feasibility of tailored, research-based strategies to promote energy conservation in military family housing. In contrast to many energy efficiency efforts, the campaign focused entirely on actions residents could take in their own homes, as opposed to technology or housing upgrades. Behavioral change was targeted because residents do not pay their own utility bills; thus other motivations must drive personal energy conservation. This campaign augments ongoing energy savings from housing upgrades carried out by Fort Lewis. The campaign ran from September 1998 through August 1999. The campaign strategy was developed based on findings from previous research and on input from residents and officials at Fort Lewis. Energy use, corrected to account for weather differences, was compared with the previous year's use. Survey responses from 377 of Fort Lewis residents of occupied housing showed that the campaign was moderately effective in promoting behavior change. Of those who were aware of the campaign, almost all said they were now doing one or more energy-efficient things that they had not done before. Most people were motivated by the desire to do the right thing and to set a good example for their children. They were less motivated by other factors.

AH McMakin; RE Lundgren; EL Malone

2000-02-23

487

Lewis acid catalysis of photochemical reactions. 5. Selective isomerization of conjugated butenoic and dienoic esters  

SciTech Connect

The effects of Lewis and Broensted acids upon the photoisomerization reactions of several conjugated butenoic and dienoic esters have been investigated. Lewis acids inhibit the photochemical deconjugation of ..cap alpha..,..beta..- to ..beta..,..gamma..-unsaturated butenoic esters and shift the photoequilibrium between E and Z isomers toward the Z isomer. As such, irradiation of E ..cap alpha..,..beta..-unsaturated esters in the presence of EtAlCl/sub 2/ provides a convenient method for the preparation of the thermodynamically less stable Z isomer. Irradiation of methyl (E,E)-2,4-hexadienoate and methyl (E,E)-5-phenyl-2,4-pentadienoate in the absence of added catalysts results in nonselective E,Z isomerization to give mixtures of all four stereoisomers in roughly comparable yields. In the presence of the Broensted acid trifluoroacetic acid, quantitative conversion of methyl 2,4-hexadienoates to methyl 3,4-hexadienoate is observed. The acid serves as a catalyst for the thermal 1,3-hydrogen shift of an allenic enol ester formed via a photochemical 1,5-hydrogen shift of the conjugated esters. Irradiation of the ground-state complexes of the conjugated esters with the Lewis acids EtAlCl/sub 2/ or BF/sub 3/ results in selective E,Z isomerization about the ..cap alpha..,..beta..-double bond in methyl 2,4-hexadienoate and the ..gamma..,delta-double bond in methyl 5-phenyl-24-pentadienoate. The mechanistic bases for the observed effects of Lewis acids are selective excitation of the more strongly absorbing E complex and more efficient isomerization of the excited E vs. Z complex.

Lewis, F.D.; Howard, D.K.; Barancyk, S.V.; Oxman, J.D.

1986-05-28

488

5-Aza-2?-deoxycytidine Increases Sialyl Lewis X on MUC1 by Stimulating ?-Galactoside ?2,3-Sialyltransferase 6 Gene  

PubMed Central

Sialyl Lewis X is a tumor-associated antigen frequently found in the advanced cancers. However, the mechanism for the production of this cancer antigen is not entirely clear. The objective of this study is to examine whether epigenetics is involved in the regulation of the formation of this antigen. We observed an increase of sialyl Lewis X in HCT15 cells, a colon cancer cell line, treated with 5-Aza-2’-deoxycytidine. This treatment enhanced the expression of ?galactoside:?2,3sialyltransferase 6 gene and sialyl Lewis X on MUC1, and the adherence of these cells to E-selectin under dynamic flow conditions. In addition, 5-Aza-2’-deoxycytidine treatment inhibited methylation of ?galactoside:?2,3sialyltransferase 6 gene and siRNA knockdown of this gene drastically reduced sialyl Lewis X without affecting MUC1 expression. We conclude that 5-Aza-2’-deoxycytidine treatment increases sialyl Lewis X on MUC1 by stimulating the ?galactoside:?2,3sialyltransferase 6 gene via inhibition of DNA methylation. Increased sialyl Lewis X by 5-Aza-2’-deoxycytidine raises a concern about the safety of this chemotherapeutic drug. In addition, ?galactoside:?2,3sialyltransferase 6 gene may be a potential therapeutic target for suppressing tumorigenicity of colon cancer.

Chachadi, Vishwanath B.; Cheng, Helen; Klinkebiel, David; Christman, Judith K.; Cheng, Pi-Wan

2011-01-01

489

Differential Gene Expression in the Nucleus Accumbens and Frontal Cortex of Lewis and Fischer 344 Rats Relevant to Drug Addiction  

PubMed Central

Drug addiction results from the interplay between social and biological factors. Among these, genetic variables play a major role. The use of genetically related inbred rat strains that differ in their preference for drugs of abuse is one approach of great importance to explore genetic determinants. Lewis and Fischer 344 rats have been extensively studied and it has been shown that the Lewis strain is especially vulnerable to the addictive properties of several drugs when compared with the Fischer 344 strain. Here, we have used microarrays to analyze gene expression profiles in the frontal cortex and nucleus accumbens of Lewis and Fischer 344 rats. Our results show that only a very limited group of genes were differentially expressed in Lewis rats when compared with the Fischer 344 strain. The genes that were induced in the Lewis strain were related to oxygen transport, neurotransmitter processing and fatty acid metabolism. On the contrary genes that were repressed in Lewis rats were involved in physiological functions such as drug and proton transport, oligodendrocyte survival and lipid catabolism. These data might be useful for the identification of genes which could be potential markers of the vulnerability to the addictive properties of drugs of abuse.

Higuera-Matas, A; Montoya, G. L; Coria, S.M; Miguens, M; Garcia-Lecumberri, C; Ambrosio, E

2011-01-01

490

Diastereoselectivity in Lewis-Acid Catalyzed Mukaiyama Aldol Reactions: A DFT Study  

PubMed Central

The basis for diastereoselectivity in Lewis acid-catalyzed Mukaiyama aldol reactions was studied using density functional theory. By exploring the conformations of the transition structures for the diastereodifferentiating step of seven different reactions, simple models were generated. The effects of varying the substituents on the enol carbon and the ?-carbon of the silyl enol ether from methyl to tert-butyl groups and the substituent on the aldehyde between methyl and phenyl groups were investigated by comparison of the transition structures for different reactions. Expanding on the previous qualitative models by Heathcock and Denmark, we found that while the pro-anti pathways takes place via antiperiplanar transition structures, the pro-syn pathways prefer synclinal transition structures. The relative steric effects of the Lewis acid and trimethyl silyl groups and the influence of E/Z isomerism on the aldol transition state were investigated. By calculating 36 transition structures at the M06/6-311G*//B3LYP/6-31G* level of theory and employing the IEFPCM polarizable continuum model for solvation effects, this study expands the mechanistic knowledge and provides a model for understanding the diastereoselectivity in Lewis acid-catalyzed Mukaiyama aldol reactions.

Lee, Joshua M.; Helquist, Paul; Wiest, Olaf

2012-01-01

491

Regularities of Lewis site formation upon the microwave irradiation of gibbsite-?-Al(OH)3  

NASA Astrophysics Data System (ADS)

Spatially separated Lewis acidic and basic sites can be formed upon the microwave irradiation of gibbsite. This is demonstrated by IR spectroscopy and indicates the possibility of the selective activation of chemical bonds of different nature within the initial crystals of Al3+ hydroxide. A scheme for the formation of spatially separated Lewis acidic and basic sites is proposed. It is shown that water as a product of the micro-wave activation of gibbsite is adsorbed on these Lewis acidic sites in molecular form (without subsequent dissociation) and is desorbed at calcination temperatures no higher than 100-110°C. During standard (contact) thermal treatment of Al3+ hydroxides and oxides, dehydroxylation and water removal take place at 350-550°C to form the acid-base pair-Al?+-O?--. The microwave activation of gibbsite results in the formation of an amorphous component believed to consist of small -Al-O- complexes closely packed in the solid phase. It is established that the fraction of Al3+ atoms accessible for the low-temperature adsorption of CO in microwave-activated (for 10 min) gibbsite is 4.5 at % of the total number of Al3+ atoms present in the amorphous component of this material.

Zhuzhgov, A. V.; Paukshtis, E. A.; Krivoruchko, O. P.; Molina, I. Yu.; Larina, T. V.; Parmon, V. N.

2013-09-01

492

Interaction between two premixed laminar V-shaped flame fronts at low Lewis number  

SciTech Connect

In studies of flamelets in premixed turbulent combustion, the interaction between laminar flames is of great importance. To study this, measurements have been made of the interaction between two premixed laminar V-shaped flames (W configuration) for a Lewis number less than 1. When the Lewis number differs greatly from unity, differential diffusion effects dominate and lead to considerable complexity. Flow visualization is used in association with laser Doppler velocimetry. Temperatures are measured with a thermocouple and species are sampled through a probe. The results show repulsion between the two oblique flame fronts separated by fresh mixture. This induces a divergent flow in the whole interaction zone and an overall shifting of the two V-shaped flames. The influence of the Lewis number is first noticeable on the unburned gases between the two flames since it induces preferential diffusion of hydrogen in the transverse direction. This leads to an increase of temperature inside the two V-shaped flames. As a consequence, it also prevents the intersection and coalescence of the two inner fronts as they propagate towards each other.

Francois, I.; Larrauri, D.; Escudie, D. [Ecole Centrale de Lyon, Ecully (France). Lab. de Mecanique des Fluides et d`Acoustique

1997-07-01

493

Metabolic and immunologic consequences of ABH secretor and Lewis subtype status.  

PubMed

Determining ABH secretor phenotype and/or Lewis (Le) blood group status can be useful to the metabolically-oriented clinician. For example, differences in ABH secretor status drastically alter the carbohydrates present in body fluids and secretions; this can have profound influence on microbial attachment and persistence. Lewis typing is one genetic marker which might help identify subpopulations of individuals genetically prone to insulin resistance, autoimmunity, and heart disease. Understanding the clinical significance of ABH secretor status and the Lewis blood groups can provide insight into seemingly unrelated aspects of physiology, including variations in intestinal alkaline phosphatase activity, propensities toward blood clotting, reliability of some tumor markers, the composition of breast milk, and several generalized aspects of the immune function. Since the relevance of ABH blood group antigens as tumor markers and parasitic/bacterial/viral receptors and their association with immunologically important proteins is now well established, the prime biologic role for ABH blood group antigens may well be independent and unrelated to the erythrocyte. PMID:11578255

D'Adamo, P J; Kelly, G S

2001-08-01

494

Lewis acid catalysis of photochemical reactions. 4. Selective isomerization of cinnamic esters  

SciTech Connect

The spectroscopic properties and photoisomerization reactions of several (E)- and (Z)-cinnamic esters, bis cinnamic esters, and model esters and lactones in the presence and absence of Lewis acids have been investigated. The use of Lewis acids such as BF/sub 3/ or EtAlCl/sub 2/ results in enhanced photoisomerization efficiency and a shift in the photoequilibrium toward the thermodynamically less stable Z isomer. Enhanced E ..-->.. Z photoisomerization results from selective excitation of ground-state ester-Lewis acid complexes. These complexes have been characterized by /sup 1/H NMR, ultraviolet, and fluorescence spectroscopies. The equilibrium constants for complexation are dependent upon both the electron donor strength of the ester and its conformational mobility. These factors also determine the magnitude of the red shifts in the electronic absorption spectra observed upon complexation. Enhanced E ..-->.. Z photoisomerization upon complex formation is a consequence of selective excitation of the E vs. Z complex, more efficient isomerization of the excited E vs. Z complex, and larger equilibrium constants for complexation of E vs. Z esters. The photoequilibria obtained for bis cinnamic esters are highly enriched in the Z,Z and Z,E isomers in accord with independent isomerization of the two cinnamate groups; however, in the case of 1,3-trimethylenebis(cinnamate), two-bond isomerization of the E,E to Z,Z isomer is observed at low conversions.

Lewis, F.D.; Oxman, J.D.; Gibson, L.L.; Hampsch, H.L.; Quillen, S.L.

1986-05-28

495

Overall Essen's experience with the E-vita open hybrid stent graft system and evolution of the surgical technique  

PubMed Central

Background The hybrid stent graft prosthesis E-vita open was designed and introduced by us in 2005 to avoid a two-stage surgical approach in the surgical treatment of complex thoracic aortic disease. Experience in ascending aortic and arch replacement with simultaneous stent grafting of the descending aorta was accumulated over the past 8 years. Facilitation of surgical technique by moving the distal suture line from Zone 3 into Zone 2 took place in 2009. We report our mid-term single-center experience comparing both surgical periods. Methods Between January 2005 and July 2013 a total of 132 patients (mean age 59±11 years) underwent one stage surgery for acute (AAD, n=74), chronic aortic dissection (CAD, n=35) or an extensive thoracic aortic aneurysm (TAA, n=23). Patients were separated in two groups according to distal anastomosis level in Zone 2 (Z2, 41/132) and Zone 3 (Z3, 91/132). Outcome, ischemic and operative times as well as adverse events were monitored during follow up. Results Overall in-hospital mortality was 13% (17/132) without difference between the groups. However, Zone 2 anastomosis resulted in reduction of cardioplegic arrest (117±39 vs. 147±35 minutes; P<0.001), selective cerebral perfusion (52±15 vs. 68±18 minutes; P<0.001) and visceral ischemic time (51±19 vs. 72±23 minutes; P<0.001). The incidence of postoperative temporary hemodialysis decreased from 40% to 20% in Z2 (P=0.028), postoperative re-exploration rate from 15% to 2% (P=0.037). No difference was found in dissection with complete false lumen thrombosis in 83% (90/109) within 10 days, as well as in TAA, where 100% aneurysm exclusion was observed. Three-year survival, freedom from thoracoabdominal aortic surgery and endovascular repair was 93%, 88%, 88%, respectively. Overall 5-year survival was 76% in AAD, 85% in CAD and 79% in TAA patients. Conclusions The dimension of surgery could be successfully reduced, indicated by significantly shortened ischemic times and postoperative complications. Durable one-stage repair of complex thoracic aortic disease could be achieved in the majority of cases with acceptable mortality. Distal reintervention is infrequent but associated with low risk when indicated.

Dohle, Daniel; Benedik, Jaroslav; Lieder, Helmut; Jakob, Heinz

2013-01-01

496

Human Milk Oligosaccharides and Lewis Blood Group: Individual High-Throughput Sample Profiling to Enhance Conclusions From Functional Studies12  

PubMed Central

Human milk oligosaccharides (HMO) are discussed to play a crucial role in an infant’s development. Lewis blood group epitopes, in particular, seem to remarkably contribute to the beneficial effects of HMO. In this regard, large-scale functional human studies could provide evidence of the variety of results from in vitro investigations, although increasing the amount and complexity of sample and data handling. Therefore, reliable screening approaches are needed. To predict the oligosaccharide pattern in milk, the routine serological Lewis blood group typing of blood samples can be applied due to the close relationship between the biosynthesis of HMO and the Lewis antigens on erythrocytes. However, the actual HMO profile of the individual samples does not necessarily correspond to the serological determinations. This review demonstrates the capabilities of merging the traditional serological Lewis blood group typing with the additional information provided by the comprehensive elucidation of individual HMO patterns by means of state-of-the-art analytics. Deduced from the association of the suggested HMO biosynthesis with the Lewis blood group, the matrix-assisted laser desorption/ionization time-of-flight mass spectrometry profiles of oligosaccharides in individual milk samples exemplify the advantages and the limitations of sample assignment to distinct groups.

Blank, Dennis; Dotz, Viktoria; Geyer, Rudolf; Kunz, Clemens

2012-01-01

497

Strategic design and refinement of Lewis acid-base catalysis by rare-earth-metal-containing polyoxometalates.  

PubMed

Efficient polyoxometalate (POM)-based Lewis acid-base catalysts of the rare-earth-metal-containing POMs (TBA(6)RE-POM, RE = Y(3+), Nd(3+), Eu(3+), Gd(3+), Tb(3+), or Dy(3+)) were designed and synthesized by reactions of TBA(4)H(4)[?-SiW(10)O(36)] (TBA = tetra-n-butylammonium) with RE(acac)(3) (acac = acetylacetonato). TBA(6)RE-POM consisted of two silicotungstate units pillared by two rare-earth-metal cations. Nucleophilic oxygen-enriched surfaces of negatively charged POMs and the incorporated rare-earth-metal cations could work as Lewis bases and Lewis acids, respectively. Consequently, cyanosilylation of carbonyl compounds with trimethylsilyl cyanide ((TMS)CN) was efficiently promoted in the presence of the rare-earth-metal-containing POMs via the simultaneous activation of coupling partners on the same POM molecules. POMs with larger metal cations showed higher catalytic activities for cyanosilylation because of the higher activation ability of C?O bonds (higher Lewis acidities) and sterically less hindered Lewis acid sites. Among the POM catalysts examined, the neodymium-containing POM showed remarkable catalytic performance for cyanosilylation of various kinds of structurally diverse ketones and aldehydes, giving the corresponding cyanohydrin trimethylsilyl ethers in high yields (13 substrates, 94-99%). In particular, the turnover frequency (714,000 h(-1)) and the turnover number (23,800) for the cyanosilylation of n-hexanal were of the highest level among those of previously reported catalysts. PMID:22672013

Suzuki, Kosuke; Sugawa, Midori; Kikukawa, Yuji; Kamata, Keigo; Yamaguchi, Kazuya; Mizuno, Noritaka

2012-06-06

498

Cell migration studies in the adoptive transfer of adjuvant arthritis in the Lewis rat.  

PubMed Central

Adjuvant arthritis (AA) can be induced in Lewis rats by a single injection of either heat-killed Mycobacterium tuberculosis or the lipoidal amine CP20961. Concanavalin A (Con A)-stimulated T cells isolated from AA rats are able to adoptively transfer the disease to naive syngeneic recipients. It is unclear, however, whether these transferred cells traffic directly to the joint and initiate arthritis, or whether secondary host cells are responsible for activation of the disease. In the current investigation, T cells labelled with the vital fluorescent dyes Hoechst H33342 and Zynaxis PKH26-G were used to adoptively transfer adjuvant disease to naive recipients. At various stages of disease development sections of ankle joints, together with a range of soft tissues, were examined by fluorescence microscopy to determine the distribution of labelled donor cells in the recipients. Intensely fluorescent lymphocytes were observed in the liver, spleen and lymph nodes within 24 hr of adoptive transfer. Foci of such cells were clearly visible in the primary lymphoid tissues as late as 14 days after transfer. However, close examination of both ankle joint sections and patellar fat pad cells throughout the time-course of the study failed to detect any labelled cells at the lesion site. To develop these observations further, we performed adoptive transfers to nude Lewis rats (rnu/rnu) and found that they were only moderately sensitive and developed, at best, a transient arthritis. This observed difference could not be explained by a generalized lack of an inflammatory response, since we were able to elicit a zymosan peritonitis in the nude rats. However, in nude Lewis rats a striking increase in adoptively transferred AA was obtained after reconstitution with 4 x 10(8) naive syngeneic spleen cells. These combined observations suggest that a host-derived immune cell population is crucial for arthritis induction in the adoptive transfer system. Images Figure 2

Van de Langerijt, A G; Volsen, S G; Hicks, C A; Craig, P J; Billingham, M E; Van den Berg, W B

1994-01-01

499

Fort Lewis natural gas and fuel oil energy baseline and efficiency resource assessment  

SciTech Connect

The mission of the US Department of Energy (DOE) Federal Energy Management Program (FEMP) is to lead the improvement of energy efficiency and fuel flexibility within the federal sector. Through the Pacific Northwest Laboratory (PNL), FEMP is developing a fuel-neutral approach for identifying, evaluating, and acquiring all cost-effective energy projects at federal installations; this procedure is entitled the Federal Energy Decision Screening (FEDS) system. Through a cooperative program between FEMP and the Army Forces Command (FORSCOM) for providing technical assistance to FORSCOM installations, PNL has been working with the Fort Lewis Army installation to develop the FEDS procedure. The natural gas and fuel oil assessment contained in this report was preceded with an assessment of electric energy usage that was used to implement a cofunded program between Fort Lewis and Tacoma Public Utilities to improve the efficiency of the Fort`s electric-energy-using systems. This report extends the assessment procedure to the systems using natural gas and fuel oil to provide a baseline of consumption and an estimate of the energy-efficiency potential that exists for these two fuel types at Fort Lewis. The baseline is essential to segment the end uses that are targets for broad-based efficiency improvement programs. The estimated fossil-fuel efficiency resources are estimates of the available quantities of conservation for natural gas, fuel oils {number_sign}2 and {number_sign}6, and fuel-switching opportunities by level of cost-effectiveness. The intent of the baseline and efficiency resource estimates is to identify the major efficiency resource opportunities and not to identify all possible opportunities; however, areas of additional opportunity are noted to encourage further effort.

Brodrick, J.R. [USDOE, Washington, DC (United States); Daellenbach, K.K.; Parker, G.B.; Richman, E.E.; Secrest, T.J.; Shankle, S.A. [Pacific Northwest Lab., Richland, WA (United States)

1993-02-01

500

Duplex development and abandonment during evolution of the Lewis thrust system, southern Glacier National Park, Montana  

SciTech Connect

The westernmost duplex (Brave Dog Mountain) includes the low-angle Brave Dog roof fault and Elk Mountain imbricate system, and the easternmost (Rising Wolf Mountain) duplex includes the low-angle Rockwell roof fault and Mt. Henry imbricate system. The geometry of these duplexes suggests that they differ from previously described geometric-kinematic models for duplex development. Their low-angle roof faults were preexisting structures that were locally utilized as roof faults during the formation of the imbricate systems. Crosscutting of the Brave Dog fault by the Mt. Henry imbricate system indicates that the two duplexes formed at different times. The younger Rockwell-Mt. Henry duplex developed 20 km east of the older Brave Dog-Elk Mountain duplex; the roof fault of the former is at a higher structural level. Field relations confirm that the low-angle Rockwell fault existed across the southern Glacier Park area prior to localized formation of the Mt. Henry imbricate thrusts beneath it. These thrusts kinematically link the Rockwell and Lewis faults and may be analogous to P shears that form between two synchronously active faults bounding a simple shear system. The abandonment of one duplex and its replacement by another with a new and higher roof fault may have been caused by (1) warping of the older and lower Brave Dog roof fault during the formation of the imbricate system (Elk Mountain) beneath it, (2) an upward shifting of the highest level of a simple shear system in the Lewis plate to a new decollement level in subhorizontal belt strata (= the Rockwell fault) that lay above inclined strata within the first duplex, and (3) a reinitiation of P-shear development (= Mt. Henry imbricate faults) between the Lewis thrust and the subparallel, synkinematic Rockwell fault.

Yin, An; Kelty, T.K.; Davis, G.A. (Univ. of Southern California, Los Angeles (USA))

1989-09-01