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Sample records for vitae lewis nelson

  1. The Nelson's syndrome... revisited.

    PubMed

    Assié, Guillaume; Bahurel, Hélène; Bertherat, Jérôme; Kujas, Michèle; Legmann, Paul; Bertagna, Xavier

    2004-01-01

    Adrenalectomy is a radical therapeutic approach to control hypercortisolism in some patients with Cushing's disease. However it may be complicated by the Nelson's syndrome, defined by the association of a pituitary macroadenoma and high ACTH secretion after adrenalectomy. This definition has not changed since the end of the fifties. Today the Nelson's syndrome must be revisited with new to criteria using more sensitive diagnostic tools, especially the pituitary magnetic resonance imaging. In this paper we will review the pathophysiological aspects of corticotroph tumor growth, with reference to the impact of adrenalectomy. The main epidemiological data on the Nelson's syndrome will be presented. More importantly, we will propose a new pathophysiological and practical approach to this question which attempts to evaluate the Corticotroph Tumor Progression after adrenalectomy, rather than to diagnose the Nelson's syndrome. We will discuss the consequences for the management of Cushing's disease patients after adrenalectomy, and will also draw some perspectives. PMID:16132203

  2. Marilyn Nelson: Poetic Justice

    ERIC Educational Resources Information Center

    Pierpont, Katherine

    2006-01-01

    This article features some of the books written by Marilyn Nelson. Here, the author discusses how she has written a children's book of poetry about lynching, entitled "A Wreath for Emmitt Till." The author discusses how her books for children honor and memorialize history-changing African Americans. Among other things, the author discusses some of…

  3. Curriculum Vitae and Related Letters.

    ERIC Educational Resources Information Center

    Peterson, Sharyl Bender

    This booklet, which was developed by a college career center, explains the purpose of and procedures for writing curriculum vitae (CV) and related letters. The following topics are covered: when a CV is appropriate, points to consider when writing a CV, items usually included, possible sections to include in a CV, and steps in writing cover…

  4. Building a Vita for the Clinical Practice.

    ERIC Educational Resources Information Center

    Tentoni, Stuart C.

    Vita review is used by most prospective employers to determine which applicants will be interviewed for a particular position opening in clinical practice. Most graduate students have little knowledge and no training in this topic, which is vital for professional development. Specific examples of vitae construction are provided for one of the…

  5. The "Curriculum Vitae": An Imperfect Mirror.

    ERIC Educational Resources Information Center

    Bennett, John B.

    1992-01-01

    Curriculum vitae for college faculty can be ambiguous and even misleading: they can obscure an individual's primary teaching and instructional achievements, tell less than they appear to, and convey an unintended message. Faculty should evaluate the clarity and force with which their vitae express their accomplishments and mirror their abilities.…

  6. A Day in the Life at DaVita Academy

    ERIC Educational Resources Information Center

    Weinstein, Margery

    2010-01-01

    When a company name means "giving life," the bar for learning and development programs is held high. In this article, the author describes what it takes to graduate from DaVita Academy, the soft skills training program dialysis services company DaVita offers all its employees. DaVita's chief executive officer, Kent Thiry, states that the Academy…

  7. 7 CFR 3402.15 - Faculty vitae.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 15 2012-01-01 2012-01-01 false Faculty vitae. 3402.15 Section 3402.15 Agriculture Regulations of the Department of Agriculture (Continued) NATIONAL INSTITUTE OF FOOD AND AGRICULTURE FOOD AND AGRICULTURAL SCIENCES NATIONAL NEEDS GRADUATE AND POSTGRADUATE FELLOWSHIP GRANTS PROGRAM Preparation of...

  8. 7 CFR 3402.15 - Faculty vitae.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 15 2011-01-01 2011-01-01 false Faculty vitae. 3402.15 Section 3402.15 Agriculture Regulations of the Department of Agriculture (Continued) NATIONAL INSTITUTE OF FOOD AND AGRICULTURE FOOD AND AGRICULTURAL SCIENCES NATIONAL NEEDS GRADUATE AND POSTGRADUATE FELLOWSHIP GRANTS PROGRAM Preparation of...

  9. 7 CFR 3402.15 - Faculty vitae.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 15 2010-01-01 2010-01-01 false Faculty vitae. 3402.15 Section 3402.15 Agriculture Regulations of the Department of Agriculture (Continued) COOPERATIVE STATE RESEARCH, EDUCATION, AND EXTENSION SERVICE, DEPARTMENT OF AGRICULTURE FOOD AND AGRICULTURAL SCIENCES NATIONAL NEEDS GRADUATE AND...

  10. 7 CFR 3402.15 - Faculty vitae.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 15 2013-01-01 2013-01-01 false Faculty vitae. 3402.15 Section 3402.15 Agriculture Regulations of the Department of Agriculture (Continued) NATIONAL INSTITUTE OF FOOD AND AGRICULTURE FOOD AND AGRICULTURAL SCIENCES NATIONAL NEEDS GRADUATE AND POSTGRADUATE FELLOWSHIP GRANTS PROGRAM Preparation of...

  11. 7 CFR 3402.15 - Faculty vitae.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 15 2014-01-01 2014-01-01 false Faculty vitae. 3402.15 Section 3402.15 Agriculture Regulations of the Department of Agriculture (Continued) NATIONAL INSTITUTE OF FOOD AND AGRICULTURE FOOD AND AGRICULTURAL SCIENCES NATIONAL NEEDS GRADUATE AND POSTGRADUATE FELLOWSHIP GRANTS PROGRAM Preparation of...

  12. Nelson Spencer (1918-2002)

    NASA Astrophysics Data System (ADS)

    Brace, Larry; Carignan, George; Donahue, Tom; Nagy, Andrew; Hunten, Donald

    Nelson Spencer, former chief of the Laboratory for Atmospheres at NASA/Goddard Space Flight Center, died on 31 August 2002 in Bethesda, Maryland, at the age of 84 due to complications from Parkinson's disease. He had been an AGU member (SPA) since 1950.He was born in Buffalo, New York, and graduated from the University of Michigan in 1941 with a degree in electrical engineering. Spencer served as a naval officer during World War II and attended Harvard and the Massachusetts Institute of Technology while in the service. After the war, he returned to the University of Michigan for graduate studies, earning his master's degree in electrical engineering in 1953. He soon became director of that department's Space Physics Research Laboratory (SPRL), and later, a full professor. In 1960, Spencer moved to Washington D.C. to lead Goddard's upper atmosphere research effort, serving for many years as chief of the Laboratory for Atmospheres. He retired in 1986.

  13. Lewy Body Disease

    MedlinePlus

    Lewy body disease is one of the most common causes of dementia in the elderly. Dementia is the loss of mental ... to affect normal activities and relationships. Lewy body disease happens when abnormal structures, called Lewy bodies, build ...

  14. Lewy bodies

    PubMed Central

    Shults, Clifford W.

    2006-01-01

    Lewy bodies (LB) in the substantia nigra are a cardinal pathological feature of Parkinson's disease, but they occur in a number of neurodegenerative diseases and can be widespread in the nervous system. The characteristics, locations, and composition of LB are reviewed, with particular attention to α-synuclein (α-SYN), which appears to be the major component of LB. The propensity for α-SYN, a presynaptic protein widely expressed in the brain, to aggregate is because of an amyloidogenic central region. The factors that favor the aggregation of α-SYN and mechanisms of toxicity are examined, and a mechanism through which aggregates of α-SYN could induce mitochondrial dysfunction and/or release of proapoptotic molecules is proposed. PMID:16449387

  15. A Conversation with Harold L. Nelson.

    ERIC Educational Resources Information Center

    Journalism History, 1979

    1979-01-01

    In this interview, Harold L. Nelson, former president of the Association for Education in Journalism and the American Association of Schools and Departments of Journalism, discusses a number of topics, including press freedom, research needs in journalism history, United States media history, and the current status of journalism history. (GT)

  16. Thomas Eshelby (1769-1811), Nelson's Surgeon.

    PubMed

    Khan, Sk; Saeed, I; Brinsden, Md

    2014-05-15

    Horatio Nelson is an icon of British naval history. His above-elbow amputation by Thomas Eshelby remains one of the most famous surgical procedures ever performed. Yet the surgeon himself remains relatively obscure and uncelebrated. We present a vignette of this young Yorkshireman and reflect on his life and times. Eshelby was a competent and conscientious surgeon and was certainly held in high regard by Nelson. Quite a few documents pertaining to his tour of duty in the Mediterranean and to his later appointment at Plymouth have been archived. These shed valuable light on his professional life, betraying his clinical acumen, his conscientious and pragmatic nature and his demeanour toward both his peers and his superiors. Eshelby was also the patriarch of an enterprising family including three generations of surgeons and others with eponymous discoveries in the fields of geography and science. PMID:24833537

  17. A professional curriculum vitae will open career doors.

    PubMed

    Harper, D S

    1999-01-01

    In today's challenging healthcare environment, it is essential for nurse practitioners to be able to describe themselves professionally on paper to compete for practice and academic opportunities. Nurse practitioners are competing with physician assistants as well as physicians for primary and acute care positions. A carefully compiled curriculum vitae will present the individual in the best light possible to help open career doors and enhance chances of success. Preparing a curriculum vitae will serve to highlight relevant professional accomplishments, whatever the setting, toward the fulfillment of professional goals. This article reviews the current professional print and electronic literature on preparing a curriculum vitae to assist the nurse practitioner in developing this vital document. PMID:10476092

  18. How Humanae vitae has advanced reproductive health1

    PubMed Central

    Doroski, Derek M.

    2014-01-01

    By encouraging doctors and scientists to improve the regulation of births through the observation of natural fertility rhythms, Humanae vitae promoted the development of natural family planning (NFP). The study of NFP has lead to NFP-based methodologies in reproductive healthcare that are promoting advances in treatment of infertility, miscarriage, and a number of reproductive health disorders. In contrast, the contraceptive mentality has stunted the development of reproductive healthcare. Humanae vitae has provided a great gift to science and reproductive healthcare that all Catholics should be proud of. PMID:25249708

  19. VITA Experiential, Service-Learning, Learned Competencies, and Changed Mindsets

    ERIC Educational Resources Information Center

    Boneck, Robin; Barnes, Jeffrey N.; Stillman, Tyler F.

    2014-01-01

    The authors describe how Southern Utah University has integrated the U.S. Internal Revenue Service (IRS) Voluntary Income Tax Assistance (VITA) program as an experiential servicelearning activity for over a decade and a half. First, we describe the value of experiential servicelearning. Second, we detail the program, its oversight, its student…

  20. Methodological Synergy in a National Project: The VITAE Story

    ERIC Educational Resources Information Center

    Day, Christopher

    2006-01-01

    VITAE was a four-year research project designed to explore the work and lives of a purposive sample of 300 Key Stage 1, 2 and 3 (English and maths) teachers at different phases of their careers in 100 primary and secondary schools in different socioeconomic contexts, drawn from seven local authorities in England. Its focus was upon identifying…

  1. Discovering Lewis and Clark

    ERIC Educational Resources Information Center

    Olsen, Ken

    2006-01-01

    Writer and historian Bernard DeVoto observed more than 50 years ago that a dismaying amount of American history has been written without regards to the Indians. Such disregard is glaring in many mainstream stories of Meriwether Lewis and William Clark. Lewis and Clark began preparing for their historic journey in 1803 and officially launched the…

  2. Lewy Body Dementia Glossary

    MedlinePlus

    ... the common cold, head trauma, exposure to toxins, Down's syndrome, Alzheimer‟s disease, Parkinson‟s disease, and Lewy body dementias. ... cerebellum and brainstem. cholinesterase: Enzyme responsible for breaking ... behavioral therapy. clinical psychology: Professional specialty ...

  3. Dementia with Lewy Bodies

    MedlinePlus

    ... of levodopa for their rigidity and loss of spontaneous movement. What is the prognosis? Like Alzheimer’s disease ... Throughout the U.S. and Worldwide NINDS Clinical Trials Organizations Column1 Column2 Lewy Body Dementia Association 912 Killian ...

  4. Application of VitaVallis dressing for infected wounds

    NASA Astrophysics Data System (ADS)

    Kirilova, N. V.; Fomenko, A. N.; Korovin, M. S.

    2015-11-01

    Today there is a growing demand for safe and efficient antimicrobial dressings for infected wound treatment. The antimicrobial sorption material for VitaVallis dressings was produced by one-stage oxidation of aluminum nanopowder in water in the presence of fibrous acetylcellulose matrix. Scanning electron microscopy revealed that the material is made up of fibers of diameter 1.5-3.0 µm with adhered agglomerated alumina nanosheets. An antimicrobial study revealed a high inhibitory effect of VitaVallis against the growth of gram-negative (E.coli, P. aeruginosa) and gram-positive (S. aureus) strains. The antimicrobial activity of the dressing against microbial pathogens on the wound surface was demonstrated in in vivo experiments on male rats. The dressing was also tested on volunteer patients. The testing showed reduction of the wound healing period, accelerated cleaning of the infected wound and enhanced tissue regeneration in the wound. The results demonstrate that the VitaVallis dressing can be used for the treatment of deep infected wounds.

  5. 2. Historic American Buildings Survey, Nelson E. Baldwin, Photographer April ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. Historic American Buildings Survey, Nelson E. Baldwin, Photographer April 30, 1936, VIEW-REAR AND SIDE ELEVATIONS, RICE HOMESTEAD, RICEVILLE, N Y. - Rice Homestead, Route 30, Mayfield, Fulton County, NY

  6. 1. Historic American Buildings Survey, Nelson E. Baldwin, Photographer April ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. Historic American Buildings Survey, Nelson E. Baldwin, Photographer April 30, 1937, VIEW-FRONT ELEVATION AND SIDE, RICE HOMESTEAD, RICEVILLE, N.Y. - Rice Homestead, Route 30, Mayfield, Fulton County, NY

  7. 4. Historic American Buildings Survey, Nelson E. Baldwin, Photographer April ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    4. Historic American Buildings Survey, Nelson E. Baldwin, Photographer April 30, 1936, VIEW-OLD KITCHEN FIREPLACE AND OVEN, RICE HOMESTEAD, RICEVILLE, N.Y. - Rice Homestead, Route 30, Mayfield, Fulton County, NY

  8. Auxiliary power controls on the Nelson River HVDC scheme

    SciTech Connect

    Chand, J. )

    1992-02-01

    This paper describes the auxiliary power controls on the Nelson River HVDC scheme. It shows how the fast control feature of the HVDC link can be utilized to enhance the operation of an integrated ac/dc power system.

  9. 5. Historic American Buildings Survey, Nelson E. Baldwin, Photographer Jan. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    5. Historic American Buildings Survey, Nelson E. Baldwin, Photographer Jan. 16, 1937, View-Dutch Oven, Basement of the Hermitage, Linlithgo, Columbia County, N.Y. - The Hermitage, Linlithgo Hamlet Vicinity, Blue Store, Columbia County, NY

  10. 1. Historic American Buildings Survey, Nelson E. Baldwin, Photographer Jan. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. Historic American Buildings Survey, Nelson E. Baldwin, Photographer Jan. 16, 1937, View-Front Elevation-The Hermitage Linlithgo, Columbia County, N Y . - The Hermitage, Linlithgo Hamlet Vicinity, Blue Store, Columbia County, NY

  11. 3. Historic American Buildings Survey, Nelson E. Baldwin, Photographer Jan. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. Historic American Buildings Survey, Nelson E. Baldwin, Photographer Jan. 16, 1937, View-Fireplace in Living Room-The Hermitage, Linlithgo, Columbia County, N Y . - The Hermitage, Linlithgo Hamlet Vicinity, Blue Store, Columbia County, NY

  12. 2. Historic American Buildings Survey, Nelson E. Baldwin, Photographer Jan. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. Historic American Buildings Survey, Nelson E. Baldwin, Photographer Jan. 16, 1937, View-Fireplace in Living Room The Hermitage, Columbia County, N.Y. - The Hermitage, Linlithgo Hamlet Vicinity, Blue Store, Columbia County, NY

  13. 4. Historic American Buildings Survey, Nelson E. Baldwin, Photographer Jan. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    4. Historic American Buildings Survey, Nelson E. Baldwin, Photographer Jan. 16, 1937, View-Fireplace in Library-The Hermitage Linlithgo, Columbia, N Y . - The Hermitage, Linlithgo Hamlet Vicinity, Blue Store, Columbia County, NY

  14. Astronauts van Hoften and Nelson conduct pre-breathing exercise

    NASA Technical Reports Server (NTRS)

    1984-01-01

    Astronauts James D. van Hoften and George D. Nelson, wearing Shuttle launch and entry helmets, conduct a pre-breathing exercise on the forward flight deck of the shuttle Challenger during the STS 41-C mission.

  15. Astronaut George Nelson working on Comet Halley Active monitoring program

    NASA Technical Reports Server (NTRS)

    1986-01-01

    Astronaut George D. Nelson smiles for a fellow crewman's photo while working on Comet Halley Active monitoring program (CHAMP). Camera equipment and a protective shroud used to eliminate all cabin light interference surround the mission specialists.

  16. STS-26 MS Nelson photographs protein crystal growth (PCG) experiments

    NASA Technical Reports Server (NTRS)

    1988-01-01

    During STS-26, Mission Specialist (MS) George D. Nelson photographs protein crystal growth (PCG) experiments on middeck. While adjusting the lens on the 35mm camera supported by a camera mounting bracket directly over PCG, Nelson looks away to smile for second crewmember (not pictured) documenting the scene. PCG carrier is deployed from the PCG refrigerator/incubator module (R/IM) located in middeck forward locker MF14H.

  17. David Nelson, MD, MPH | Division of Cancer Prevention

    Cancer.gov

    Dr. David E Nelsonis the Director of the Cancer Prevention Fellowship Program (CPFP) Branch in the National Cancer Institute's Division of Cancer Prevention. The CPFP is an internationally renowned postdoctoral program designed to train early career scientific researchers and leaders in the field of cancer prevention. Dr. Nelson came to the CPFP in 2008 after working at the Centers for Disease Control and Prevention in Atlanta for many years. |

  18. David Nelson, MD, MPH | Division of Cancer Prevention

    Cancer.gov

    Dr. David E Nelson is the Director of the Cancer Prevention Fellowship Program (CPFP) Branch in the National Cancer Institute's Division of Cancer Prevention. The CPFP is an internationally renowned postdoctoral program designed to train early career scientific researchers and leaders in the field of cancer prevention. Dr. Nelson came to the CPFP in 2008 after working at the Centers for Disease Control and Prevention in Atlanta for many years. |

  19. Dementia with lewy bodies.

    PubMed

    Posner, H; Chin, S; Marder, K

    2001-10-17

    In this case study, we describe the symptoms, neuropsychological testing, and brain pathology of a man with dementia with Lewy bodies. Dementia with Lewy bodies might be the second most common form of degenerative dementia in the elderly. Progressive cognitive decline, well-formed visual hallucinations, and parkinsonism are core features of this disease. This case was marked by preserved verbal expression despite impairment in memory, visuospatial skills, and attention span. Development of visual symptoms and parkinsonism occurred very early in the course of the disease. PMID:14602963

  20. Neuropathology of Lewy body disorders.

    PubMed

    Kövari, Enikö; Horvath, Judit; Bouras, Constantin

    2009-10-28

    The spectrum of Lewy body disorders includes not only Parkinson's disease, dementia with Lewy bodies and Parkinson's disease associated dementia but also Lewy body dysphagia and autonomic failure with Lewy bodies. In the last years an increasing number of cases showing Lewy body pathology has been recognised at autopsy. In fact, dementia with Lewy bodies is thought to be the second most frequent degenerative cause of cognitive decline in elderly after Alzheimer's disease, representing about 20% of dementia cases. The clinical diagnosis of dementia with Lewy bodies and of Parkinson's disease dementia is determinant for prognosis and therapeutic management, namely for avoiding increased sensibility to neuroleptics. The recent progress of neuropathology in this field made it possible to define clinical and neuropathological guidelines for the diagnosis. This review briefly describes the most important data of all Lewy body related disorders. PMID:19576266

  1. Lewy body dementias.

    PubMed

    Walker, Zuzana; Possin, Katherine L; Boeve, Bradley F; Aarsland, Dag

    2015-10-24

    The broad importance of dementia is undisputed, with Alzheimer's disease justifiably getting the most attention. However, dementia with Lewy bodies and Parkinson's disease dementia, now called Lewy body dementias, are the second most common type of degenerative dementia in patients older than 65 years. Despite this, Lewy body dementias receive little attention and patients are often misdiagnosed, leading to less than ideal management. Over the past 10 years, considerable effort has gone into improving diagnostic accuracy by refining diagnostic criteria and using imaging and other biomarkers. Dementia with Lewy bodies and Parkinson's disease dementia share the same pathophysiology, and effective treatments will depend not only on successful treatment of symptoms but also on targeting the pathological mechanisms of disease, ideally before symptoms and clinical signs develop. We summarise the most pertinent progress from the past 10 years, outlining some of the challenges for the future, which will require refinement of diagnosis and clarification of the pathogenesis, leading to disease-modifying treatments. PMID:26595642

  2. The Curriculum Vitae--What It Is and What It Is Not.

    ERIC Educational Resources Information Center

    Newcomb, B. Joan; Murphy, Patricia A.

    1979-01-01

    Presents guidelines to nurses for preparing curriculum vitae, narrower and more stylized than resumes, which outline qualifications for academic positions, committees, and honors. Lists categories and describes content of information to be included on a vita (a sample is shown) and notes what to avoid. (MF)

  3. U.S. Rep. Bill Nelson of Florida during medical tests at JSC's Clinic

    NASA Technical Reports Server (NTRS)

    1985-01-01

    U.S. Rep. Bill Nelson of Florida during medical tests at JSC's Clinic. Photos include Rep. Nelson talking to Sharon Briceno (center) and Betty Lord before the tests begin. The congressman's torso bears a number of sensors for the testing (40835); Portrait view of Rep. Nelson with sensors attached to his chest (40836); Rep. Nelson gets some assistance from nurses at the clinic as he prepares to participate in medical tests. Help is provided by Betty Lord, right, and Sharon Briceno (40837); Rep. Nelson is being assisted to don 'halo' device for tests (40838); Rep. Nelson runs in place on a treadmill device (40839).

  4. Motor and cognitive function in Lewy body dementia: comparison with Alzheimer's and Parkinson's diseases.

    PubMed Central

    Gnanalingham, K K; Byrne, E J; Thornton, A; Sambrook, M A; Bannister, P

    1997-01-01

    OBJECTIVE: Motor and cognitive function were compared in patients with Lewy body dementia, Parkinson's disease, or Alzheimer's disease, to identify features that may be clinically useful in differentiating Lewy body dementia from Alzheimer's disease and Parkinson's disease. METHODS: A range of neuropsychological function and extrapyrimidal signs (EPS) was assessed in 16 patients with Lewy body dementia, 15 with Parkinson's disease, 25 with Alzheimer's disease, and 22 control subjects. RESULTS: The severity of total motor disability scores increased in the following order: controls approximately = Alzheimer's disease << Parkinson's disease < Lewy body dementia. Compared with patients with Parkinson's disease, patients with Lewy body dementia had greater scores for rigidity and deficits in the finger tapping test, but rest tremor and left/right asymmetry in EPS were more evident in Parkinson's disease. Patients with Lewy body dementia were also less likely to present with left/right asymmetry in EPS at the onset of their parkinsonism. "Sensitivity" to neuroleptic drugs was noted in 33% of patients with Lewy body dementia. Alzheimer's disease and Lewy body dementia groups had greater severity of dementia compared with the Parkinson's disease group and controls. Neuropsychological evaluation disclosed severe but similar degrees of impaired performances in tests of attention (digit span), frontal lobe function (verbal fluency, category, and Nelson card sort test) and motor sequencing in both Lewy body dementia and Alzheimer's disease groups, than Parkinson's disease and controls. In the clock face test, improved performance was noted in the "copy" compared to "draw" part of the test in controls, patients with Alzheimer's disease, and those with Parkinson's disease, but not in the patients with Lewy body dementia, who achieved equally poor scores in both parts of the test. CONCLUSIONS: EPS in Lewy body dementia resemble those seen in idiopathic Parkinson's disease, although less rest tremor and left/right asymmetry but more severe rigidity favours a diagnosis of Lewy body dementia. The unique profile of patients with Lewy body dementia seen in the clock face test suggests that this simple and easy to administer test may be useful in the clinical setting to differentiate Lewy body dementia and Alzheimer's disease. Images PMID:9069479

  5. STS-26 MS Nelson on fixed based (FB) shuttle mission simulator (SMS) middeck

    NASA Technical Reports Server (NTRS)

    1988-01-01

    STS-26 Discovery, Orbiter Vehicle (OV) 103, Mission Specialist (MS) George D. Nelson trains on the middeck of the fixed based (FB) shuttle mission simulator (SMS). Nelson, wearing communications assembly headset, adjusts camera mounting bracket.

  6. Edwin W. Lewis, Jr.

    NASA Technical Reports Server (NTRS)

    1999-01-01

    Edwin W. Lewis Jr. is a research pilot in the Airborne Science program, Flight Crew Branch, Dryden Flight Research Center, Edwards, California. He currently flies the DC-8, F/A-18, Lear Jet 24, King Air, and T-34C in support of Dryden's flight operations and is mentor pilot for the King Air and the Lear Jet. Prior to accepting this assignment Lewis was a pilot for eight years at NASA's Ames Research Center, Moffett Field, California, flying 10 different aircraft - C-130B, DC-8-72, UH-1, SH-3, King Air, Lear 24, T-38A, T-39G and YO-3A - in support of NASA flight missions. Lewis also flew the Kuiper Airborne Observatory (a modified civilian version of the Lockheed C-141 Starlifter). He was project pilot for Ames' 747 and T-38 programs. Lewis was born in New York City on May 19, 1936, and began flight training as a Civil Air Patrol cadet in 1951, ultimately earning his commercial pilot's certificate in 1958. He received a bachelor of arts degree in biology from Hobart College, Geneva, N.Y., and entered the U.S. Air Force through the Reserve Officer Training Corps. Following pilot training he was assigned to Moody Air Force Base, Ga., as an instructor pilot, for both the T-33 and T-37 aircraft. He served in Vietnam in 1965 and 1966, where he was a forward air controller, instructor and standardization/evaluation pilot, flying more than 1,000 hours in the O-1 'Bird Dog.' Lewis separated from the regular Air Force and joined Pan American World Airways and the 129th Air Commando Group, California Air National Guard (ANG) based in Hayward, California. During his 18-year career with the California ANG he flew the U-6, U-10, C-119, HC-130 aircraft and the HH-3 helicopter. He retired as commander, 129th Air Rescue and Recovery Group, a composite combat rescue group, in the grade of colonel. During his 22 years as an airline pilot, he flew the Boeing 707, 727 and 747. He took early retirement from Pan American in 1989 to become a pilot with NASA.

  7. STS-26 Mission Specialist Nelson in LES prior to JSC WETF emergency exercises

    NASA Technical Reports Server (NTRS)

    1988-01-01

    STS-26 Discovery, Orbiter Vehicle (OV) 103, Mission Specialist (MS) George D. Nelson, wearing newly designed (navy blue) launch and entry suit (LES), gets some moral support from Aimee Tess Nelson, his sixteen-year-old lifeguard daughter. Nelson was about to participate in a simulation of escape and rescue operations utilizing the crew escape system (CES) pole mode of egress from the Space Shuttle. Nelson is equipped with the LES partial pressure suit and parachute gear.

  8. Philosophical Remarks on Nelson Mandela's Education Legacy

    ERIC Educational Resources Information Center

    Waghid, Yusef

    2014-01-01

    In this article, I reflect on Nelson Mandela's (Madiba, the clan name of Mandela) education legacy. I argue that Madiba's education legacy is constituted by three interrelated aspects: firstly, an education for non-violence guided by deliberation, compassion and reconciliation; secondly, education as responsibility towards the Other; and

  9. A Good Time: A Conversation with C. Michael Nelson

    ERIC Educational Resources Information Center

    Zabel, Robert; Kaff, Marilyn; Teagarden, Jim

    2015-01-01

    C. Michael Nelson began his special education career as a teacher of adolescents with learning and behavior disorders. He has worked as a child psychologist and as a professor with the Department of Special Education and Rehabilitation Counseling at the University of Kentucky. He coordinated the graduate Personnel Preparation Program for Teachers…

  10. Corner Office Interview: SirsiDynix's Rautenstrauch and Nelson

    ERIC Educational Resources Information Center

    Rapp, David; Fialkoff, Francine

    2010-01-01

    This article presents an interview with SirsiDynix CEO Gary M. Rautenstrauch and newly appointed VP of library relations Berit Nelson about some of the issues that have been roiling the ILS world and the company itself, among them the recent consolidation of SirsiDynix's offices, customer service, the state of library budgets, the rise of ebooks…

  11. Philosophical Remarks on Nelson Mandela's Education Legacy

    ERIC Educational Resources Information Center

    Waghid, Yusef

    2014-01-01

    In this article, I reflect on Nelson Mandela's (Madiba, the clan name of Mandela) education legacy. I argue that Madiba's education legacy is constituted by three interrelated aspects: firstly, an education for non-violence guided by deliberation, compassion and reconciliation; secondly, education as responsibility towards the Other; and…

  12. John Nelson Darby: Scholarship that Influenced the Bible College Movement

    ERIC Educational Resources Information Center

    Sutherland, Winston Terrance

    2010-01-01

    The study reported in this article focused on the scholastic life of John Nelson Darby and his contributions to the Bible college movement. Darby continues to exert a great influence on Christianity, particularly conservative evangelical Christianity. This research provides a discussion of the forces that conspired to shape the direction of…

  13. John Nelson Darby: His Contributions to Evangelical Christian Higher Education

    ERIC Educational Resources Information Center

    Sutherland, Winston Terrance

    2010-01-01

    The study reported in this article focused on the contributions of John Nelson Derby to biblical hermeneutics and contemporary eschatological thought. Darby continues to exert a great influence on Christianity, particularly conservative evangelical Christianity. This research provides a discussion of Darby's contributions to contemporary…

  14. 2. Historic American Buildings Survey, Nelson E. Baldwin, Photographer, Jan. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. Historic American Buildings Survey, Nelson E. Baldwin, Photographer, Jan. 16, 1937, View - Interior Door Opening into Apartment on First Floor, 123 North Pearl St., Albany, N.Y. - Old Homeopathic Hospital (Interiors), 123 North Pearl Street, Albany, Albany County, NY

  15. 1. Historic American Buildings Survey, Nelson E. Baldwin, Photographer, Jan. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. Historic American Buildings Survey, Nelson E. Baldwin, Photographer, Jan. 16, 1937, View - Stairway from First to Second Floor Old Homeopathic Hospital (Office of the HABS), Albany, N.Y. - Old Homeopathic Hospital (Interiors), 123 North Pearl Street, Albany, Albany County, NY

  16. 4. Historic American Buildings Survey, Nelson E. Baldwin, Photographer, Jan. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    4. Historic American Buildings Survey, Nelson E. Baldwin, Photographer, Jan. 16, 1937, View - Second to Third Floor Stairs Old Homeopathic Hospital, 123 North Pearl St., Albany, N.Y. - Old Homeopathic Hospital (Interiors), 123 North Pearl Street, Albany, Albany County, NY

  17. 3. Historic American Buildings Survey, Nelson E. Baldwin, Photographer, Jan. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. Historic American Buildings Survey, Nelson E. Baldwin, Photographer, Jan. 16, 1937, View - Double Doors and Columns in Apartment on First Floor, 123 North Pearl St., Albany, N.Y. - Old Homeopathic Hospital (Interiors), 123 North Pearl Street, Albany, Albany County, NY

  18. Astronaut Nelson practices EVA to repair Solar Maximum Satellite

    NASA Technical Reports Server (NTRS)

    1984-01-01

    Astronaut George D. Nelson, 41-C mission specialist, moves toward the model of the Solar Maximus Satellite with a trunion pin attachment device (TPAD). This practice is being held in the Martin-Marietta manned maneuvering unit (MMU) simulator in Denver, Colorado.

  19. STS-26 Mission Specialist Nelson in T-38 rear cockpit

    NASA Technical Reports Server (NTRS)

    1988-01-01

    STS-26 Discovery, Orbiter Vehicle (OV) 103, Mission Specialist (MS) George D. Nelson, wearing helmet, sits in T-38 rear cockpit prior to departure from Ellington Field for Kennedy Space Center (KSC). STS-26 crewmembers are scheduled for a September 29 launch.

  20. Silenced but Not Silent: The Rhetorical Influence of Nelson Mandela.

    ERIC Educational Resources Information Center

    Boyd, Susy

    In the epicenter of the political strife in South Africa is former African National Congress (ANC) leader Nelson Mandela. The ANC is considered to be the leading source of opposition to white rule in South Africa, and Mandela is one of the most revered and powerful figures to emerge from that organization. Incarcerated for over 25 years on charges…

  1. A Message from Nelson Mandela to the Youth of America.

    ERIC Educational Resources Information Center

    Mandela, Nelson

    1995-01-01

    Presents a message to young people from Nelson Mandela, president of South Africa. Calls for a bridge between the youth of Africa and the United States. Asserts that racial divisions in the United States are major social issues that must be solved. (CFR)

  2. In Honor of Eyak: The Art of Anna Nelson Harry.

    ERIC Educational Resources Information Center

    Krauss, Michael E., Ed.

    Ten stories, in poem and narrative form, told by Anna Nelson Harry, are presented here. The stories represent a portion of the oral tradition of the Eyak, an Alaskan native nation of which few native speakers remain. An introductory section chronicles the history and decline of the Eyak, the research undertaken to preserve their culture, and the…

  3. 75 FR 22437 - Community Volunteer Income Tax Assistance (VITA) Matching Grant Program-Availability of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-28

    ... Internal Revenue Service Community Volunteer Income Tax Assistance (VITA) Matching Grant Program--Availability of Application Packages AGENCY: Internal Revenue Service (IRS), Treasury. ACTION: Notice. SUMMARY... service by the deadline date. Application packages should be mailed to: Internal Revenue Service,...

  4. 76 FR 30243 - Community Volunteer Income Tax Assistance (VITA) Matching Grant Program-Availability of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-24

    ... Internal Revenue Service Community Volunteer Income Tax Assistance (VITA) Matching Grant Program--Availability of Application Packages AGENCY: Internal Revenue Service (IRS), Treasury. ACTION: Notice. SUMMARY... service by the deadline date. ADDRESSES: Internal Revenue Service, Grant Program Office, 401...

  5. Lewis Incubator for Technology (LIFT)

    NASA Technical Reports Server (NTRS)

    Zeman, Wayne P.; King, Joseph B.; Jankura, Richard E., Jr.

    2004-01-01

    This report summarizes the work done to operate the Lewis Incubator for Technology for the period October 2000 through September 2004. The Lewis Incubator helped the startup and growth of technology based businesses with the potential to incorporate technology from the NASA Glenn Research Center.

  6. STS-26 Mission Specialists Hilmers and Nelson during wardrobe fitting

    NASA Technical Reports Server (NTRS)

    1987-01-01

    STS-26 Discovery, Orbiter Vehicle (OV) 103, Mission Specialist (MS) David C. Hilmers (left) and MS George D. Nelson, with the aid of mirrors, attempt to find the best 'fits' in flight coveralls (jump suits) during wardrobe fitting conducted at the Boeing Building near JSC. The two STS-26 mission specialists will be joined by three other veteran astronauts for NASA's first Shuttle flight since the Challenger accident 01-28-86.

  7. [Dementia with Lewy bodies].

    PubMed

    Orimo, Satoshi

    2016-03-01

    It is important to differentiate dementia with Lewy bodies (DLB) and other dementia, especially Alzheimer disease (AD), because the medical treatment, management, and the prognosis of these diseases are different. In regard to clinical features, DLB patients have relatively mild memory disturbance, fluctuating cognition, more severe disturbances of attention, executive function, visuospacial function, visual hallucination, depression, autonomic symptoms, REM sleep behavior disorder, and idiopathic parkinsonism compared to AD patients. In regard to imaging tools, DLB patients have milder atrophy of medial temporal lobe by brain MRI, reduced occipital activity by SPECT or PET, reduced MIBG uptake by MIBG cardiac scintigraphy, and low dopamine transporter activity in the basal ganglia by SPECT or PET. PMID:27025091

  8. Lewy body disease and dementia with Lewy bodies

    PubMed Central

    KOSAKA, Kenji

    2014-01-01

    In 1976 we reported our first autopsied case with diffuse Lewy body disease (DLBD), the term of which we proposed in 1984. We also proposed the term “Lewy body disease” (LBD) in1980. Subsequently, we classified LBD into three types according to the distribution pattern of Lewy bodies: a brain stem type, a transitional type and a diffuse type. Later, we added the cerebral type. As we have proposed since 1980, LBD has recently been used as a generic term to include Parkinson’s disease (PD), Parkinson’s disease with dementia (PDD) and dementia with Lewy bodies (DLB), which was proposed in 1996 on the basis of our reports of DLBD. DLB is now known to be the second most frequent dementia following Alzheimer’s disease (AD). In this paper we introduce our studies of DLBD and LBD. PMID:25311140

  9. What Is Lewy Body Dementia?

    MedlinePlus

    ... brain chemical acetylcholine is depleted, causing disruption of perception, thinking and behavior. Lewy body dementia exists either in pure form, or in conjunction with other brain changes, including those typically seen in Alzheimer's ...

  10. An interview with Lewis Wolpert.

    PubMed

    Wolpert, Lewis; Vicente, Catarina

    2015-08-01

    Lewis Wolpert is a retired developmental biologist who, over his long career, has made many important contributions to the field, from his French Flag model and the concept of positional information to the famous quote that it is "not birth, marriage or death, but gastrulation which is truly the most important time in your life." In addition to his scientific contributions, Lewis is also a prolific writer, from the textbook 'Developmental Biology' to books about popular science, religion and his battle with depression. Although born in South Africa, it was in the United Kingdom that Lewis spent most of his scientific career. We met Lewis at the Spring Meeting of the British Society for Developmental Biology, where he was awarded the Waddington Medal. PMID:26243866

  11. Dementia with Lewy bodies

    PubMed Central

    Graff-Radford, Jonathan; Murray, Melissa E.; Lowe, Val J.; Boeve, Bradley F.; Ferman, Tanis J.; Przybelski, Scott A.; Lesnick, Timothy G.; Senjem, Matthew L.; Gunter, Jeffrey L.; Smith, Glenn E.; Knopman, David S.; Jack, Clifford R.; Dickson, Dennis W.; Petersen, Ronald C.

    2014-01-01

    Objectives: To investigate clinical, imaging, and pathologic associations of the cingulate island sign (CIS) in dementia with Lewy bodies (DLB). Methods: We retrospectively identified and compared patients with a clinical diagnosis of DLB (n = 39); patients with Alzheimer disease (AD) matched by age, sex, and education (n = 39); and cognitively normal controls (n = 78) who underwent 18F-fluorodeoxyglucose (FDG) and C11 Pittsburgh compound B (PiB)-PET scans. Among these patients, we studied those who came to autopsy and underwent Braak neurofibrillary tangle (NFT) staging (n = 10). Results: Patients with a clinical diagnosis of DLB had a higher ratio of posterior cingulate to precuneus plus cuneus metabolism, cingulate island sign (CIS), on FDG-PET than patients with AD (p < 0.001), a finding independent of β-amyloid load on PiB-PET (p = 0.56). Patients with CIS positivity on visual assessment of FDG-PET fit into the group of high- or intermediate-probability DLB pathology and received clinical diagnosis of DLB, not AD. Higher CIS ratio correlated with lower Braak NFT stage (r = −0.96; p < 0.001). Conclusions: Our study found that CIS on FDG-PET is not associated with fibrillar β-amyloid deposition but indicates lower Braak NFT stage in patients with DLB. Identifying biomarkers that measure relative contributions of underlying pathologies to dementia is critical as neurotherapeutics move toward targeted treatments. PMID:25056580

  12. Dementia with Lewy bodies.

    PubMed

    McKeith, Ian

    2004-09-01

    Dementia with Lewy bodies (DLB) is the second most common cause of neurodegenerative dementia in older people, accounting for 10% to 15% of all cases, it occupies part of a spectrum that includes Parkinson's disease and primary autonomic failure. All these diseases share a neuritic pathology based upon abnormal aggregation of the synaptic protein α-synuciein. It is important to identify DLB patients accurately because they have specific symptoms, impairments, and functional disabilities thai differ from other common dementia syndromes such as Alzheimer's disease, vascular cognitive impairment, and frontotemporal dementia. Clinical diagnostic criteria for DLB have been validated against autopsy, but fail to detect a substantial minority of cases with atypical presentations that are often due to the presence of mixed pathology. DLB patients frequently have severe neuroleptic sensitivity reactions, which are associated with significantly increased morbidity and mortality. Cholinesterase inhibitor treatment is usually well tolerated and substantially improves cognitive and neuropsychiatrie symptoms. Although virtually unrecognized 20 years ago, DLB could within this decade become one of the most treatable neurodegenerative disorders of late life. PMID:22033743

  13. Rep. Bill Nelson during space food and consumables orientation and suit fitting

    NASA Technical Reports Server (NTRS)

    1987-01-01

    Rita Rapp, a flight coordinator, briefs U.S. Rep. Bill Nelson (D.-Florida) on space food during an orientation session in the life sciences laboratory at JSC (27753); Rep. Nelson tries on a glove during a suit fitting session (27754); Rep. Nelson samples a package of re-hydratable fruit in the life sciences laboratory during early STS 61-C training (27755); Rep. Nelson listens to Laura Louviere brief him on hygiene articles soon after reporting to Houston for STS 61-C training. On the table in front of him is a tube marked Palmalive, a tube marked Gillette and various other articles (27756).

  14. STS-26 MS Nelson during Crew escape system (CES) testing in JSC WETF Bldg 29

    NASA Technical Reports Server (NTRS)

    1988-01-01

    STS-26 Discovery, Orbiter Vehicle (OV) 103, Mission Specialist (MS) George D. Nelson participates in crew escape system (CES) testing in JSC Weightless Environment Training Facility (WETF) Bldg 29. Nelson, wearing the newly designed (navy blue) launch and entry suit (LES), is suspended over the WETF pool by parachute gear. SCUBA-equipped divers, already in the pool, watch as Nelson is raised above the pool. Technician monitors the test activities from the pool side. During the exercise, a new CES pole for emergency exit from the Space Shuttle was tested. Nelson's parachute gear is like that each STS-26 crewmember and subsequent crews will carry onboard during launch.

  15. Failure Analysis of Main Flame Deflector Nelson Studs

    NASA Technical Reports Server (NTRS)

    Long, Victoria

    2009-01-01

    NASA Structures engineers submitted two Nelson refractory studs from the main flame deflector at Launch Complex (LC) 39 A for analysis when they were observed to be missing a significant amount of material after launch. The damaged stud and an unused comparative stud were analyzed by macroscopic and microscopic examination along with metallographic evaluation of the microstructure. The stud lost material due to a combination of erosion and corrosion. Plain carbon steel readily forms an oxide layer in the coastal launch environment at Kennedy Space Center. The blast during a launch removes this brittle oxide layer, which then forms again post-launch, thereby further removing material. No indications of melting were observed.

  16. 76 FR 56455 - DaVita, Inc.; Analysis of Agreement Containing Consent Orders To Aid Public Comment

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-13

    ... terms of the Consent Agreement, DaVita is required to divest 28 dialysis clinics and terminate one... clinics by requiring DaVita to divest--prior to acquiring DSI--29 outpatient dialysis clinics to Dialysis... affiliated with the divested clinics to continue providing physician services after the transfer of...

  17. Antimicrobial Potential and Chemical Characterization of Serbian Liverwort (Porella arboris-vitae): SEM and TEM Observations

    PubMed Central

    Kumar Tyagi, Amit; Bukvicki, Danka; Gottardi, Davide; Veljic, Milan; Guerzoni, Maria Elisabetta; Malik, Anushree; Marin, Petar D.

    2013-01-01

    The chemical composition of Porella arboris-vitae extracts was determined by solid phase microextraction, gas chromatography-mass spectrometry (SPME GC-MS), and 66 constituents were identified. The dominant compounds in methanol extract of P. arboris-vitae were β-caryophyllene (14.7%), α-gurjunene (10.9%), α-selinene (10.8%), β-elemene (5.6%), γ-muurolene (4.6%), and allo-aromadendrene (4.3%) and in ethanol extract, β-caryophyllene (11.8%), α-selinene (9.6%), α-gurjunene (9.4%), isopentyl alcohol (8.8%), 2-hexanol (3.7%), β-elemene (3.7%), allo-aromadendrene (3.7%), and γ-muurolene (3.3%) were the major components. In ethyl acetate extract of P. arboris-vitae, undecane (11.3%), β-caryophyllene (8.4%), dodecane (6.4%), α-gurjunene (6%), 2-methyldecane (5.1%), hemimellitene (4.9%), and D-limonene (3.9%) were major components. The antimicrobial activity of different P. arboris-vitae extracts was evaluated against selected food spoilage microorganisms using microbroth dilution method. The Minimal Inhibitory Concentration (MIC) varied from 0.5 to 1.5 mg/mL and 1.25 to 2 mg/mL for yeast and bacterial strains, respectively. Significant morphological and ultrastructural alterations due to the effect of methanolic and ethanolic P. arboris-vitae extracts on S. Enteritidis have also been observed by scanning electron microscope and transmission electron microscope, respectively. The results provide the evidence of antimicrobial potential of P. arboris-vitae extracts and suggest its potential as natural antimicrobial agents for food preservation. PMID:23365607

  18. 100 years of Lewy pathology.

    PubMed

    Goedert, Michel; Spillantini, Maria Grazia; Del Tredici, Kelly; Braak, Heiko

    2013-01-01

    In 1817, James Parkinson described the symptoms of the shaking palsy, a disease that was subsequently defined in greater detail, and named after Parkinson, by Jean-Martin Charcot. Parkinson expected that the publication of his monograph would lead to a rapid elucidation of the anatomical substrate of the shaking palsy; in the event, this process took almost a century. In 1912, Fritz Heinrich Lewy identified the protein aggregates that define Parkinson disease (PD) in some brain regions outside the substantia nigra. In 1919, Konstantin Nikolaevich Tretiakoff found similar aggregates in the substantia nigra and named them after Lewy. In the 1990s, α-synuclein was identified as the main constituent of the Lewy pathology, and its aggregation was shown to be central to PD, dementia with Lewy bodies, and multiple system atrophy. In 2003, a staging scheme for idiopathic PD was introduced, according to which α-synuclein pathology originates in the dorsal motor nucleus of the vagal nerve and progresses from there to other brain regions, including the substantia nigra. In this article, we review the relevance of Lewy's discovery 100 years ago for the current understanding of PD and related disorders. PMID:23183883

  19. STS-26 MS Nelson prepares meal at galley on Discovery's middeck

    NASA Technical Reports Server (NTRS)

    1988-01-01

    STS-26 Mission Specialist (MS) George D. Nelson, wearing thermal underwear, positions himself in front of the orbiter galley using the intravehicular activity (IVA) foot restraints and prepares a meal on Discovery's, Orbiter Vehicle (OV) 103's, middeck. Beverage containers are velcroed to the galley shelf as Nelson rehydrates a food package.

  20. STS-26 MS Nelson watches as Boeing personnel alter his flight coveralls

    NASA Technical Reports Server (NTRS)

    1987-01-01

    STS-26 Discovery, Orbiter Vehicle (OV) 103, Mission Specialist (MS) George D. Nelson watches as Boeing personnel alter his flight coveralls (jump suit) during wardrobe fitting conducted at the Boeing Building near JSC. Dr. Nelson will be joined be five other veteran NASA astronauts for the Space Agency's first Shuttle flight since the Challenger accident 01-28-86.

  1. STS-26 crewmember Hauck and Nelson in T-38 NASA 912 arrive at KSC SLF

    NASA Technical Reports Server (NTRS)

    1988-01-01

    STS-26 Discovery, Orbiter Vehicle (OV) 103, Commander Frederick H. Hauck (left) and Mission Specialist (MS) George D. Nelson arrive at Kennedy Space Center (KSC) Shuttle Landing Facility (SLF) for terminal countdown demonstration test (TCDT) activities. With T-38 canopies open Hauck and Nelson prepare to climb out of jet aircraft.

  2. STS-26 MS Nelson prepares for EVA exercises at JSC's WETF Bldg 29

    NASA Technical Reports Server (NTRS)

    1988-01-01

    STS-26 Discovery, Orbiter Vehicle (OV) 103, Mission Specialist (MS) George D. Nelson, wearing extravehicular mobilty unit (EMU) and communications carrier assembly (CCA), stands on poolside platform while technicians assist him with EMU gloves. Nelson dons EMU for contingency extravehicular activity (EVA) exercises in JSC's Weightless Environment Training Facility (WETF) Bldg 29. Photograph was taken by Keith Meyers of the NEW YORK TIMES.

  3. The Vita Activa as Compass: Navigating Uncertainty in Teaching with Hannah Arendt

    ERIC Educational Resources Information Center

    Rogers, Carrie Ann Barnes

    2010-01-01

    This dissertation is an exploration of stories of uncertainty in the lives of elementary teachers and the value that the ideas of Hannah Arendt lend to the discussion around uncertainty. In "The Human Condition" (1958) Hannah Arendt theorizes the life of action, the "vita activa". Arendtian action is inherently uncertain because to be "capable of

  4. 75 FR 25314 - Community Volunteer Income Tax Assistance (VITA) Matching Grant Program-Availability of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-07

    ... Wednesday, April 28, 2010 (75 FR 22437). This notice provides notice of the availability of application...) Matching Grant Program, which was the subject of FR Doc. 2010-9771, is corrected as follows: On page 22437... Internal Revenue Service Community Volunteer Income Tax Assistance (VITA) Matching Grant...

  5. 78 FR 17776 - Community Volunteer Income Tax Assistance (VITA) Matching Grant Program-Availability of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-22

    ... Internal Revenue Service Community Volunteer Income Tax Assistance (VITA) Matching Grant Program--Availability of Application Packages AGENCY: Internal Revenue Service (IRS), Treasury. ACTION: Notice. SUMMARY... Program is May 31, 2013. All applications must be submitted through Grants.gov . ADDRESSES:...

  6. 77 FR 20694 - Community Volunteer Income Tax Assistance (VITA) Matching Grant Program-Availability of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-05

    ... Internal Revenue Service Community Volunteer Income Tax Assistance (VITA) Matching Grant Program--Availability of Application Packages AGENCY: Internal Revenue Service (IRS), Treasury. ACTION: Notice. SUMMARY... Program is May 31, 2012. All applications must be submitted through Grants.gov . ADDRESSES:...

  7. The Vita Activa as Compass: Navigating Uncertainty in Teaching with Hannah Arendt

    ERIC Educational Resources Information Center

    Rogers, Carrie Ann Barnes

    2010-01-01

    This dissertation is an exploration of stories of uncertainty in the lives of elementary teachers and the value that the ideas of Hannah Arendt lend to the discussion around uncertainty. In "The Human Condition" (1958) Hannah Arendt theorizes the life of action, the "vita activa". Arendtian action is inherently uncertain because to be "capable of…

  8. Using the Curriculum Vita To Study the Career Paths of Scientists and Engineers: An Assessment.

    ERIC Educational Resources Information Center

    Lane, Eliesh O'Neil; Dietz, James S.; Chompalov, Ivan; Bozeman, Barry; Park, Jongwon

    The usefulness of the curriculum vita (CV) as a data source for examining the career paths of scientists and engineers was studied. CVs were obtained in response to an e-mail message sent to researchers working in the area of biotechnology who were funded by the National Science Foundation (55 responses) or listed as authors (industry only) in the…

  9. Lewis and Clark as Naturalists.

    ERIC Educational Resources Information Center

    Smithsonian Institution, Washington, DC. National Museum of Natural History.

    Intended for use in elementary and high school education, this Web site includes a teacher's guide and three lesson plans. The site contains images of museum specimens, scientific drawings, and field photos of the plant and animal species observed by Meriwether Lewis and William Clark, along with journal excerpts, historical notes, and references…

  10. Lewis & Clark: An Interdisciplinary Expedition

    ERIC Educational Resources Information Center

    Brugar, Kristy

    2004-01-01

    On January 18, 1803 President Thomas Jefferson asked Congress to fund an expedition to the source of the Missouri River. This expedition would become known as the Corps of Discovery, which would spend twenty-eight months exploring, studying, and documenting the wonders of the western frontier. Led by Captains Meriwether Lewis and William Clark,…

  11. Dr. Lewis' 10-Year Audit.

    PubMed

    Berlin, Joey

    2015-11-01

    Kaufman pediatrician Charles Turner Lewis, MD, battled fraud allegations levied against him by the Office of Inspector General (OIG) from 2005 to 2008 and emerged victorious. To his dismay, he is once again on the receiving end of an OIG letter alleging Medicaid overpayment. The 2015 Texas Legislature responded to TMA's call for improvements in OIG Medicaid fraud investigations of physicians with passage of Senate Bill 207. Organized medicine hopes the law's safeguards will afford due process to doctors under investigation. PMID:26536514

  12. 3 CFR 9067 - Proclamation 9067 of December 5, 2013. Death of Nelson Mandela

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... President embodied the promise that human beings—and countries—can change for the better. His commitment to..., and the world has lost an inspiration for freedom, justice, and human dignity—Nelson Mandela is...

  13. Science student experimenter Todd Nelson with STS-3 crew Lousma and Fullerton

    NASA Technical Reports Server (NTRS)

    1982-01-01

    Science student experimenter Todd Nelson meets with STS-3 crew Commander Jack R. Lousma, left, and Pilot C. Gordon Fullerton to discuss his experiment 'Insects in flight motion study' during a press briefing in JSC's public affairs facility.

  14. Official portrait of Rep. Bill Nelson, STS 61-C payload specialist

    NASA Technical Reports Server (NTRS)

    1985-01-01

    Official portrait of Congressman Bill Nelson, U.S. House of Representatives - Florida, STS 61-C payload specialist. He is in the blue shuttle flight suit, holding a model of the shuttle with an American flag behind him.

  15. Astronaut George Nelson uses one-G version of MMU to prepare for EVA

    NASA Technical Reports Server (NTRS)

    1984-01-01

    Astronaut George D. Nelson, 41-C mission specialist, uses a one-G version of manned maneuvering unit (MMU) to prepare for his upcoming extravehicular activity (EVA). The simulator is located in JSC's avionics systems laboratory.

  16. New synchronous compensators for the Nelson River HVDC system; Planning requirements and specifications

    SciTech Connect

    Thio, C.V.; Davies, J.B. )

    1991-04-01

    The first units of Limestone Generating Station, the third plant on the Lower Nelson River in northern Manitoba, will come into service in the fall of 1990. Additional var compensation equipment is required at the inverter end of the Nelson River HVdc system to accommodate power from Limestone. This paper describes the system requirements of and the overall specification for the synchronous compensators selected to supply the reactive power and voltage support.

  17. STS-26 MS Nelson prepares for EVA exercises at JSC's WETF Bldg 29

    NASA Technical Reports Server (NTRS)

    1988-01-01

    STS-26 Discovery, Orbiter Vehicle (OV) 103, Mission Specialist (MS) George D. Nelson, wearing liquid cooling and ventilation garment (LCVG), works with inner glove before donning extravehicular mobility unit (EMU) lower torso (positioned on chair between technicians). Nelson, standing with technicians on the poolside, is preparing for contingency extravehicular activity (EVA) exercises in JSC's Weightless Environment Training Facility (WETF) Bldg 29. Photograph was taken by Keith Meyers of the NEW YORK TIMES.

  18. Effective Design and Evaluation of Serious Games: The Case of the e-VITA Project

    NASA Astrophysics Data System (ADS)

    Pappa, Dimitra; Pannese, Lucia

    Learning and training are presently facing new challenges and a strong transformation. The use of electronic games for education (game-based learning) promotes an agile, immersive and stimulating form of learning that fosters learner engagement and motivation. Nonetheless, the design of effective and engaging educational games is a creative process that is unique to each situation. This paper discusses the inherent challenges of building intellectually appropriate and engaging games and presents the methodology adopted in the case of the e-VITA project that applies GBL to promote knowledge sharing and transfer for intergenerational learning. The paper analyses the e-VITAframework for SGs evaluation, which is central to the project's iterative development approach. Early findings stemming from the validation of the e-VITA prototype game are also presented.

  19. Conservative Diffusions: a Constructive Approach to Nelson's Stochastic Mechanics.

    NASA Astrophysics Data System (ADS)

    Carlen, Eric Anders

    In Nelson's stochastic mechanics, quantum phenomena are described in terms of diffusions instead of wave functions; this thesis is a study of that description. We emphasize that we are concerned here with the possibility of describing, as opposed to explaining, quantum phenomena in terms of diffusions. In this direction, the following questions arise: "Do the diffusions of stochastic mechanics--which are formally given by stochastic differential equations with extremely singular coefficients--really exist?" Given that they exist, one can ask, "Do these diffusions have physically reasonable sample path behavior, and can we use information about sample paths to study the behavior of physical systems?" These are the questions we treat in this thesis. In Chapter I we review stochastic mechanics and diffusion theory, using the Guerra-Morato variational principle to establish the connection with the Schroedinger equation. This chapter is largely expository; however, there are some novel features and proofs. In Chapter II we settle the first of the questions raised above. Using PDE methods, we construct the diffusions of stochastic mechanics. Our result is sufficiently general to be of independent mathematical interest. In Chapter III we treat potential scattering in stochastic mechanics and discuss direct probabilistic methods of studying quantum scattering problems. Our results provide a solid "Yes" in answer to the second question raised above.

  20. Simplified Lewis Structure Drawing for Nonscience Majors.

    ERIC Educational Resources Information Center

    Miburo, Barnabe B.

    1998-01-01

    Argues that Lewis diagrams can be easily done by students using a minimal number of clues. Presents a method to draw the Lewis structure of molecules, polyatomic ions, and radicals whereby students no longer need to move bonds or lone pairs of electrons. (DDR)

  1. The linear shade guide design of Vita 3D-master performs as well as the original design of the Vita 3D-master.

    PubMed

    Corcodel, N; Rammelsberg, P; Jakstat, H; Moldovan, O; Schwarz, S; Hassel, A J

    2010-11-01

    Visual tooth colour assessment by use of the Vita 3D-Master(®) (3D; Vita Zahnfabrik, Bad Säckingen, Germany) is well documented. To improve handling, a new linear arrangement of the shade tabs has been introduced (LG; Linearguide 3D-Master(®) ). The purpose of this study was to investigate whether the linear design has an effect on shade matching. Fifty-six students underwent identical, theoretical and practical training, by use of an Internet learning module [Toothguide Training Software(®) (TT)] and a standardised training programme [Toothguide Training Box(®) (TTB)]. Each student then matched 30 randomly chosen shade tabs presented in an intra-oral setting by a standardised device [Toothguide Check Box(®) (TCB)]; 15 matches were made using the 3D and 15 using the LG shade guide system, under a daylight lamp (840 matches for each guide). It was recorded to what extent the presented and selected shade tabs, or the lightness group of the tabs, matched, also the needed time for colour matching. The results showed that 35% of perfect matches were observed for the 3D and 32% for the LG. The lightness group was correct in 59% of cases for 3D and 56% for LG. Mean time needed for matching of tabs and lightness group was no different between groups (no significant difference for any assessment). Within the limitations of the study design, the colour assessment with regard to performance and time needed in shade matching was not different with the LG or the 3D. Therefore, the user should choose which shade tab arrangement is more applicable. PMID:20633072

  2. [From Parkinson's disease to Lewy body disease].

    PubMed

    Bordet, R; Destée, A

    1992-04-18

    Lewy bodies are intraneuronal inclusions initially found in the pigmented brainstem nuclei of patients with Parkinson's disease. Their aspect varies according to their neuronal or cerebral situation. They have been a long time the hallmark of Parkinson's disease, but in recent years it has emerged that a small group of rare disorders or rare variants of common degenerative diseases are also sometimes associated with Lewy bodies in the nervous system. Pathological studies have also individualized a new disorder characterized by the presence of numerous Lewy bodies throughout the cerebral cortex and the brainstem: Lewy body disease. The clinical syndrome associates dementia, parkinsonian features, dysautonomia and motor neuron disease. The dementia is cortical in type and psychiatric symptoms such as agitation, hallucinations or delusions are frequent. The pathological features are nerve cell loss, diffuse Lewy bodies, and sometimes senile plaques. The origin of this disorder remains unclear, but it could be a primitive abnormality of neuronal cytoskeleton. PMID:1534893

  3. Second generation video imaging technique for assessing dermal exposure (VITAE System).

    PubMed

    Fenske, R A; Birnbaum, S G

    1997-09-01

    Development of a second-generation video imaging technique for assessing occupational skin exposure (VITAE) is described, its performance evaluated, and new procedures for exposure quantification are presented. The current VITAE system has higher resolution in regard to both its picture element array and gray scale when compared with the prototype system. System performance was evaluated during extended field deployment: variability was 3-4% during data acquisition for individual worker evaluation session, and 10% over a 22-day study period. Variabilities attributable to subject positioning and image outlining procedures were 2.7 and 1.2%, respectively. Visual observations of fluorescent tracer deposition on skin were used to classify specific body regions as either exposed of unexposed, and two computer-based classification criteria were tested against the visual classification. These criteria were generally better at minimizing false negative and false positive classification; sensitivity and predictive value reached 95 and 99%, respectively, when analysis was preceded by presampling of a subset of images. Variability in skin pigmentation was found to have a substantial effect on fluorescent tracer qualification, leading to development of new calibration procedures. Standard curves were generated by spotting a range of tracer concentrations on volunteer subjects and quantifying fluorescence with the VITAE system. These data were then grouped either by subject or by the magnitude of the background signal of the unexposed skin. The ability to control for the effects of skin pigmentation was found to be comparable for these grouping methods, indicating that calibration curves can be developed without the creation of a unique curve for each subject. PMID:9291561

  4. Imported Case of Acute Respiratory Tract Infection Associated with a Member of Species Nelson Bay Orthoreovirus

    PubMed Central

    Sakai, Kouji; Singh, Harpal; Himeji, Daisuke; Kikuchi, Ikuo; Ueda, Akira; Yamamoto, Seigo; Miura, Miho; Shioyama, Yoko; Kawano, Kimiko; Nagaishi, Tokiko; Saito, Minako; Minomo, Masumi; Iwamoto, Naoyasu; Hidaka, Yoshio; Sohma, Hirotoshi; Kobayashi, Takeshi; Kanai, Yuta; Kawagishi, Takehiro; Nagata, Noriyo; Fukushi, Shuetsu; Mizutani, Tetsuya; Tani, Hideki; Taniguchi, Satoshi; Fukuma, Aiko; Shimojima, Masayuki; Kurane, Ichiro; Kageyama, Tsutomu; Odagiri, Takato; Saijo, Masayuki; Morikawa, Shigeru

    2014-01-01

    A Japanese man suffered from acute respiratory tract infection after returning to Japan from Bali, Indonesia in 2007. Miyazaki-Bali/2007, a strain of the species of Nelson Bay orthoreovirus, was isolated from the patient's throat swab using Vero cells, in which syncytium formation was observed. This is the sixth report describing a patient with respiratory tract infection caused by an orthoreovirus classified to the species of Nelson Bay orthoreovirus. Given the possibility that all of the patients were infected in Malaysia and Indonesia, prospective surveillance on orthoreovirus infections should be carried out in Southeast Asia. Furthermore, contact surveillance study suggests that the risk of human-to-human infection of the species of Nelson Bay orthoreovirus would seem to be low. PMID:24667794

  5. STS-26 MS Nelson during Crew Escape System (CES) testing in JSC WETF Bldg 29

    NASA Technical Reports Server (NTRS)

    1988-01-01

    STS-26 Discovery, Orbiter Vehicle (OV) 103, Mission Specialist (MS) George D. Nelson participates in crew escape system (CES) testing in JSC Weightless Environment Training Facility (WETF) Bldg 29. With helmet visor down, Nelson, wearing the newly designed (navy blue) launch and entry suit (LES), floats in WETF pool with the aid of an underarm flotation device (modern version of Mae West floats). He awaits the assistance of SCUBA-equipped divers during a simulation of escape and rescue operations utilizing a new CES pole for emergency exit from the Space Shuttle.

  6. STS-26 MS Nelson during Crew escape system (CES) testing in JSC WETF Bldg 29

    NASA Technical Reports Server (NTRS)

    1988-01-01

    STS-26 Discovery, Orbiter Vehicle (OV) 103, Mission Specialist (MS) George D. Nelson participates in crew escape system (CES) testing in JSC Weightless Environment Training Facility (WETF) Bldg 29. Nelson, wearing the newly designed (navy blue) launch and entry suit (LES), floats in WETF pool with the aid of an underarm flotation device (modern version of Mas West floats). He awaits the assistance of SCUBA-equipped divers during a simulation of escape and rescue operations utilizing a new CES pole for emergency exit from the Space Shuttle.

  7. STS-26 MS Nelson poses with the infrared communications flight experiment

    NASA Technical Reports Server (NTRS)

    1988-01-01

    STS-26 Discovery, Orbiter Vehicle (OV) 103, Mission Specialist (MS) George D. Nelson poses with components of the infrared communications flight experiment (IRCFE) in the JSC Communications and Tracking Development Laboratory Bldg 44 Audio Lab rm 143. Nelson will operate the IRCFE, wearing a belt dotted with three infrared light-emitting diode modules, which broadcast signals; and three photodiode modules, which receive signals. The lightweight portable transceiver and headset are exactly the same size as the interim wireless crew communications system (WCCS), the system first used aboard the orbiter.

  8. Making the Impossible Possible. Review of "Embracing Victory: Life Lessons in Competition and Compassion," by Mariah Burton Nelson.

    ERIC Educational Resources Information Center

    Lenk, Linda L.

    1998-01-01

    An adolescent aversion to competition helped the reviewer/marathoner appreciate Mariah Burton Nelson's "Embracing Victory: Life Lessons in Competition and Compassion" (Morrow, 1998). Nelson, a former collegiate and professional basketball player, focuses on female athletes' and nonathletes' attitudes about numerous competition-related topics.

  9. Cation affinity numbers of Lewis bases

    PubMed Central

    Lindner, Christoph; Tandon, Raman; Maryasin, Boris; Larionov, Evgeny

    2012-01-01

    Summary Using selected theoretical methods the affinity of a large range of Lewis bases towards model cations has been quantified. The range of model cations includes the methyl cation as the smallest carbon-centered electrophile, the benzhydryl and trityl cations as models for electrophilic substrates encountered in Lewis base-catalyzed synthetic procedures, and the acetyl cation as a substrate model for acyl-transfer reactions. Affinities towards these cationic electrophiles are complemented by data for Lewis-base addition to Michael acceptors as prototypical neutral electrophiles. PMID:23019478

  10. The Help-line "Invito alla Vita": a new project for suicide prevention in Trentino region.

    PubMed

    Di Napoli, Wilma; Andreatta, Olaf

    2014-11-01

    "Invito alla Vita" is a community-based suicide prevention project that officially started in Trentino in late 2008. The project was promoted by the local Health Services, trying from the beginning to involve other community subjects, and has been working over five years and a half in different directions, particularly promoting a phone help-line. The aims of the Invito alla Vita (IaV) Help Line have been clear from the beginning: decrease the sense of loneliness, offer encouragement and support, promote engagement with health services, reduce stigma and prejudice. Contrary to popular misconceptions, talking with people about suicide will not increase suicide risk, neither will it induce patients to commit suicide.The volunteers involved in the IaV help-line offer people empathic listening without judgment and easy tips, to reduce loneliness, sadness and supply reassurance that other people care. In this study we tried to deepen our knowledges about the volunteers' motivations and necessities to use them for creating a better system of support: we realized indeed that continuous training and supervision, along with official awards given by community institutions, are basic factors to sustain the volunteers' motives to cooperate with the help line. PMID:25413532

  11. Historical and biochemical aspects of a seventeenth century gold-based aurum vitae recipe.

    PubMed

    Rubbiani, Riccardo; Wahrig, Bettina; Ott, Ingo

    2014-08-01

    The medicinal chemistry and biomedical applications of gold complexes have been intensively studied over the last decades. Some complexes have been used for the treatment of rheumatoid arthritis, and a considerable number of new metallodrug candidates have been developed as new anticancer drugs and anti-infectives. However, the therapeutic use of gold and its complexes goes back to ancient times and was also of great importance for alchemists until the modern age. In this report, we give an overview of the alchemic medicine between the sixteenth and the early eighteenth century and describe the cytotoxicity and thioredoxin reductase (TrxR) inhibition of a typical "aurum vitae" medicine, which was prepared according to a recipe by Bartholomäus Kretschmar from the seventeenth century. "Aurum vitae" consists of a mixture of gold, mercury and antimony complexes and shows the expected cytotoxic and TrxR inhibitory properties providing some rationale for therapeutic effects of this kind of historical medicinal preparation. PMID:24748221

  12. The Use of C. S. Lewis's "Poems" for Oral Interpretation.

    ERIC Educational Resources Information Center

    Keefe, Carolyn

    Suggestions are offered in this paper for adapting C. S. Lewis's poems for oral interpretation. A discussion of Lewis's lifelong correspondence with his friend Arthur Greeves provides insights into Lewis's perceptions of his own writing. Eighty poems selected from Lewis's "Poems" as appropriate for oral interpretation are classified according to…

  13. Development of a Lewis Base Catalyzed Selenocyclization Reaction

    ERIC Educational Resources Information Center

    Collins, William

    2009-01-01

    The concept of Lewis base activation of selenium Lewis acids has been effectively reduced to practice in the Lewis base catalyzed selenofunctionalization of unactivated olefins. In this reaction, the weakly acidic species, "N"-phenylselenyl succinimide, is cooperatively activated by the addition of a "soft" Lewis base donor (phosphine sulfides,…

  14. The Use of C. S. Lewis's "Poems" for Oral Interpretation.

    ERIC Educational Resources Information Center

    Keefe, Carolyn

    Suggestions are offered in this paper for adapting C. S. Lewis's poems for oral interpretation. A discussion of Lewis's lifelong correspondence with his friend Arthur Greeves provides insights into Lewis's perceptions of his own writing. Eighty poems selected from Lewis's "Poems" as appropriate for oral interpretation are classified according to

  15. 90 Seconds of Discovery: Frustrated Lewis Pairs

    SciTech Connect

    Kathmann, Shawn; Schenter, Greg; Autrey, Tom

    2014-02-14

    Hydrogen activating catalysts play an important role in producing valuable chemicals, such as biofuels and ammonia. As a part of efforts to develop the next generation of these catalysts, PNNL researchers have found potential in Frustrated Lewis Pairs.

  16. 90 Seconds of Discovery: Frustrated Lewis Pairs

    ScienceCinema

    Kathmann, Shawn; Schenter, Greg; Autrey, Tom

    2014-07-21

    Hydrogen activating catalysts play an important role in producing valuable chemicals, such as biofuels and ammonia. As a part of efforts to develop the next generation of these catalysts, PNNL researchers have found potential in Frustrated Lewis Pairs.

  17. Lewis Research Center: Commercialization Success Stories

    NASA Technical Reports Server (NTRS)

    Heyward, Ann O.

    1996-01-01

    The NASA Lewis Research Center, located in Cleveland, Ohio, has a portfolio of research and technology capabilities and facilities that afford opportunities for productive partnerships with industry in a broad range of industry sectors. In response to the President's agenda in the area of technology for economic growth (Clinton/Gore 1993), the National Performance Review (1993), NASA's Agenda for Change (1994), and the needs of its customers, NASA Lewis Research Center has sought and achieved significant successes in technology transfer and commercialization. This paper discusses a sampling of Lewis Research Center's successes in this area, and lessons learned that Lewis Research Center is applying in pursuit of continuous improvement and excellence in technology transfer and commercialization.

  18. G. N. Lewis and the Chemical Bond.

    ERIC Educational Resources Information Center

    Pauling, Linus

    1984-01-01

    Discusses the contributions of G. N. Lewis to chemistry, focusing on his formulation of the basic principle of the chemical bond--the idea that the chemical bond consists of a pair of electrons held jointly by two atoms. (JN)

  19. Pueblo Pottery: Continuity and Change. Lucy Lewis.

    ERIC Educational Resources Information Center

    Herzog, Melanie

    1991-01-01

    Describes Lucy Lewis' ceramic work which is inspired by the ancient pottery of her Acoma Pueblo artistic heritage. Discusses concepts of tradition, artistic heritage, and change over time. Outlines related ceramic and discussion activities for elementary and secondary students. (KM)

  20. Abegg, Lewis, Langmuir, and the Octet Rule.

    ERIC Educational Resources Information Center

    Jensen, William B.

    1984-01-01

    Discusses major events leading to the development of the octet rule. Three conclusions based on the work of Mendeleev, Abegg, Thompson, Kossel, Lewis, and Langmuir are considered as is the debate over the rule's validity. (JN)

  1. Adult Learners: New Norms on the Nelson-Denny Reading Test for Healthcare Professionals.

    ERIC Educational Resources Information Center

    Haught, Patricia A.; Walls, Richard T.

    2002-01-01

    Presents new norms on the Nelson-Denny Reading Test for healthcare-professional students. Notes that it is generally accepted that professional and graduate schools require students with good reading ability because of the quantity of material to be read. Presents standard scores, percentile ranks, and stanine scores as revised norms based on test…

  2. Assessment of General Education Competencies at Thomas Nelson Community College, 1994-1997.

    ERIC Educational Resources Information Center

    Quanty, Michael B.; And Others

    In 1997, Virginia's Thomas Nelson Community College (TNCC) undertook a study to determine how well the general education components of its associate degree programs were imparted to associate degree graduates. Four sources of data were used to determine outcomes: follow-up survey results for 1992-93 and 1993-94 graduates, outcomes for graduate…

  3. 78 FR 56224 - Hydro Nelson, Ltd.; Hydro-WM, LLC; Notice of Transfer of Exemption

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-12

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Hydro Nelson, Ltd.; Hydro-WM, LLC; Notice of Transfer of Exemption 1. By documentation filed July 8, 2013 and supplemented on September 4, 2013, Hydro-WM, LLC informed the...

  4. "Finding Useful Questions: On Bayesian Diagnosticity, Probability, Impact, and Information Gain": Correction to Nelson (2005)

    ERIC Educational Resources Information Center

    Nelson, Jonathan D.

    2007-01-01

    Reports an error in "Finding Useful Questions: On Bayesian Diagnosticity, Probability, Impact, and Information Gain" by Jonathan D. Nelson (Psychological Review, 2005[Oct], Vol 112[4], 979-999). In Table 13, the data should indicate that 7% of females had short hair and 93% of females had long hair. The calculations and discussion in the article…

  5. Celebrating the Hero in All of Us: An Interview with Kadir Nelson

    ERIC Educational Resources Information Center

    Sableski, Mary-Kate; Arnold, Jackie Marshall; Adomat, Donna Sayers

    2015-01-01

    Books provide an opportunity through which children can learn what it means to be in the world and to respond flexibly and creatively to a diverse range of situations. Author/illustrator Kadir Nelson creates books that provide these opportunities for readers of all ages. A dominant theme in current conversations surrounding children's literature…

  6. U.S. Rep. William Nelson drinking tea from shuttle beverage container

    NASA Technical Reports Server (NTRS)

    1985-01-01

    U.S. Rep. William Nelson of Florida tries drinking tea from a straw-equipped beverage dispenser in JSC's life sciences laboratory during a space food orientation session. The congressman is in early stages of training for a position on the STS 61-C mission.

  7. Radical Questioning on the Long Walk to Freedom: Nelson Mandela and the Practice of Critical Reflection

    ERIC Educational Resources Information Center

    Brookfield, Stephen

    2008-01-01

    Nelson Mandela's autobiography "The Long Walk to Freedom" describes how an iconic political activist and freedom fighter reflected on, and sometimes modified, four core assumptions at the heart of his struggle to overturn the White supremacist, minority hegemony and create a free South Africa. Critical reflection's focus is on understanding the…

  8. "Passageless" Administration of the Nelson-Denny Reading Comprehension Test: Associations with IQ and Reading Skills

    ERIC Educational Resources Information Center

    Ready, Rebecca E.; Chaudhry, Maheen F.; Schatz, Kelly C.; Strazzullo, Sarah

    2013-01-01

    There are few tests that assess reading comprehension in adults, but these tests are needed for a comprehensive assessment of reading disorders (RD). "The Nelson-Denny Reading Test" (NDRT) has a long-passage reading comprehension component that can be used with adolescents and adults. A problem with the NDRT is that reading comprehension test…

  9. Radical Questioning on the Long Walk to Freedom: Nelson Mandela and the Practice of Critical Reflection

    ERIC Educational Resources Information Center

    Brookfield, Stephen

    2008-01-01

    Nelson Mandela's autobiography "The Long Walk to Freedom" describes how an iconic political activist and freedom fighter reflected on, and sometimes modified, four core assumptions at the heart of his struggle to overturn the White supremacist, minority hegemony and create a free South Africa. Critical reflection's focus is on understanding the

  10. STS-26 MS Nelson adjusts ADSF power cable on Discovery's middeck

    NASA Technical Reports Server (NTRS)

    1988-01-01

    STS-26 Mission Specialist (MS) George D. Nelson adjusts power cable on automated directional solidification furnace (ADSF) support electronics package. ADSF is located in forward (starboard side) lockers on Discovery's, Orbiter Vehicle (OV) 103's, middeck. ADSF consists of the furnace container (left) and the control electronics container (right). An Air National Guard, Houston, Texas, decal appears on middeck locker above ADSF.

  11. Astronauts Crippen and Nelson board T-38 for trip to KSC

    NASA Technical Reports Server (NTRS)

    1984-01-01

    Astronauts Robert Crippen,left, STS 41-C crew commander, and Mission specialist George Nelson prepare to leave Ellington Air Base in a NASA T-38 for the Kennedy Space Center (KSC). They are already wearing their helmets and oxygen masks in preparation for take-off.

  12. Astronaut Nelson wipes off helmet visor in the middeck of Shuttle Challenger

    NASA Technical Reports Server (NTRS)

    1984-01-01

    Astronaut George D. Nelson, 41-C mission specialist, wipes off his helmet visor in the middeck of Shuttle Challenger. Astronaut James D. van. Hoften, is seen in the background. Both crew members are wearing the liquid cooled undergarments for the extravehicular mobility unit (EMU).

  13. STS-26 Mission Specialist Nelson in T-38 rear station at Ellington Field

    NASA Technical Reports Server (NTRS)

    1987-01-01

    STS-26 Discovery, Orbiter Vehicle (OV) 103, Mission Specialist (MS) George D. Nelson, wearing flight helmet, sits in T-38 jet aircraft rear station at Ellington Field. Hilmers awaits departure for Kennedy Space Center (KSC) where the crew will interface with flight hardware.

  14. Shaping Influences on the Leadership of Genghis Khan, George Washington, and Nelson Mandela: Applications for Educators

    ERIC Educational Resources Information Center

    Bongila, Jean-Pierre

    2011-01-01

    Using a prosopographical methodology this study examines common leadership influences that might have existed among Genghis Khan, George Washington, and Nelson Mandela. Shoup (2005) suggests that the following seven influences have contributed to nurturing the leadership of 12 renowned individuals: involved parents, happy childhood, formal,…

  15. Coherent Backscattering: Conceptions and Misconceptions (Reply to Comments by Bruce W. Hapke and Robert M. Nelson)

    NASA Technical Reports Server (NTRS)

    Tishkovets, Victor P.; Mishchenko, Michael

    2010-01-01

    Although the note by Hapke and Nelson has virtually no relevance to our original publication, it contains a number of statements that are misleading and/or wrong. We, therefore, use this opportunity to dispel several profound misconceptions that continue to hinder the progress in remote sensing of planetary surfaces.

  16. Adult Learners: New Norms on the Nelson-Denny Reading Test for Healthcare Professionals.

    ERIC Educational Resources Information Center

    Haught, Patricia A.; Walls, Richard T.

    2002-01-01

    Presents new norms on the Nelson-Denny Reading Test for healthcare-professional students. Notes that it is generally accepted that professional and graduate schools require students with good reading ability because of the quantity of material to be read. Presents standard scores, percentile ranks, and stanine scores as revised norms based on test

  17. Research and technology, Lewis Research Center

    NASA Technical Reports Server (NTRS)

    1985-01-01

    The NASA Lewis Research Center's research and technology accomplishments for fiscal year 1985 are summarized. The report is organized into five major sections covering aeronautics, aerospace technology, spaceflight systems, space station systems, and computational technology support. This organization of the report roughly parallels the organization of the Center into directorates. Where appropriate, subheadings are used to identify special topics under the major headings. Results of all research and technology work performed during the fiscal year are contained in Lewis-published technical reports and presentations prepared either by Lewis scientists and engineers or by contractor personnel. In addition, significant results are presented by university faculty or graduate students in technical sessions and in journals of the technical societies. For the reader who desires more information about a particular subject, the Lewis contact will provide that information or references. In 1985, five Lewis products were selected by Research and Development Magazine for IR-100 awards. All are described and identified. In addition, the Lewis Distinguished Paper for 1984 to 1985, which was selected by the Chief Scientist and a research advisory board, is included and so identified.

  18. The Professoriate in the Field of Educational Administration: Insights from an Analysis of Journal Authors' Curricula Vitae

    ERIC Educational Resources Information Center

    Oplatka, Izhar

    2010-01-01

    Purpose: Based on a qualitative content analysis of 57 curricula vitae of authors who published their work in the major journals of the educational administration (EA) field, this paper seeks to display the career of EA authors and to suggest some epistemological implications for the field. Design/methodology/approach: The analysis is based on…

  19. E-vita open plus for treating complex aneurysms and dissections of the thoracic aorta: a NICE medical technology guidance.

    PubMed

    Radhakrishnan, Muralikrishnan; Peacock, Janet; Rua, Tiago; Clough, Rachel E; Ofuya, Mercy; Wang, Yanzhong; Morris, Elizabeth; Lewis, Cornelius; Keevil, Stephen

    2014-10-01

    The E-vita open plus is a one-stage endoluminal stent graft system used for treating complex aneurysms and dissections of the thoracic aorta. The National Institute for Health and Care Excellence (NICE), as a part of its Medical Technologies Evaluation Programme (MTEP), selected this device for evaluation and invited the manufacturer, JOTEC GmbH, to submit clinical and economic evidence. King's Technology Evaluation Centre (KiTEC), an External Assessment Centre (EAC) commissioned by the NICE, independently critiqued the manufacturer's submissions. The EAC considered that the manufacturer had included most of the relevant evidence for the E-vita open plus, based on international E-vita open registry data for 274 patients, but had provided only limited evidence for the comparators. The EAC therefore conducted a systematic review and meta-analysis of all comparators to supplement the information, and found ten additional studies providing outcome data for the three two-stage comparators. The EAC noted that the cost model submitted by the manufacturer did not include key complications during the procedures. The EAC developed a new economic model incorporating data on complications along with their long-term costs. The revised model indicated that the E-vita open plus might not provide cost savings when compared with some of the comparators in the short-term (1 year), but would have high cost savings in the long-term, from the second year onwards. The NICE Medical Technologies Guidance MTG 16, issued in December 2013, recommended the adoption of the E-vita open plus in selected patients within the National Health Service in England. PMID:25056415

  20. Prospective Assessment of an innovative test for prostate cancer screening using the VITA process model framework.

    PubMed

    Gantner-Bär, Marion; Meier, Florian; Kolominsky-Rabas, Peter; Djanatliev, Anatoli; Metzger, Armin; Voigt, Wieland; Prokosch, Hans-Ulrich; Sedlmayr, Martin

    2014-01-01

    Healthcare innovations are crucial for enhancing patient treatment and a high-quality healthcare system. However, bringing new technologies, methods and procedures into the healthcare market is challenging. Enormous amounts of financial, personnel and organizational resources are required with no upfront certainty for the medical and economic benefit. A new and innovative approach uses interdisciplinary medical, technical and economic expertise to forecast effects of healthcare innovations already at the early research and concept phase of an idea and before major investments are made. A process model framework was developed to operationalize this structured assessment of healthcare innovations. The Visionary Iterative Tailored Approach (VITA) is based on conceptual modeling, simulation and health economics evaluation. Its application for the prospective assessment of an innovative prostate cancer screening is presented. PMID:25160181

  1. Donum Vitae on homologous interventions: is IVF-ET a less acceptable gift than "GIFT"?

    PubMed

    Carlson, J W

    1989-10-01

    Donum Vitae argues that, by failing to respect the connection between the conjugal act and procreation, in vitro fertilization-even in the homologous or "simple case", where both gametes come from a married couple and the resulting embryo is transferred to the wife-shows itself to be morally unacceptable. On the other hand, the document refers approvingly to other technological interventions which "facilitate" or "assist" the conjugal act in achieving its objective. Although none of the latter interventions are mentioned by name, the recently developed gamete intrafallopian transfer (GIFT) and certain associated techniques have found favor with many orthodox Roman Catholic thinkers, as well with some church authorities. The present article explores this situation in the Catholic moral tradition, and offers reasons for believing that, given relevantly similar conditions, if GIFT is morally acceptable so also is homologous IVF-ET. PMID:2607242

  2. Out of their comfort zone. Dialysis provider DaVita needs to integrate big physician practice to move toward integrated care.

    PubMed

    Kutscher, Beth

    2013-09-16

    DaVita's acquisition of multispecialty group HealthCare Partners hasn't come without growing pains. But the deal has put the dialysis provider in a position to go beyond kidneys to serving the whole patient. The goal of the merger, says DaVita Co-chairman and CEO Kent Thiry, left, is to prepare for a time when DaVita is expected not only to provide dialysis, but also help keep nephrology patients out of the hospital and manage their other chronic conditions. PMID:24199234

  3. Rocket Propulsion Research at Lewis Research Center

    NASA Technical Reports Server (NTRS)

    Dawson, Virginia P.

    1992-01-01

    A small contingent of engineers at NASA Lewis Research Center pioneered in basic research on liquid propellants for rockets shortly after World War II. Carried on through the 1950s, this work influenced the important early decisions made by Abe Silverstein when he took charge of the Office of Space Flight Programs for NASA. He strongly supported the development of liquid hydrogen as a propulsion fuel in the face of resistance from Wernher von Braun. Members of the Lewis staff played an important role in bringing liquid hydrogen technology to the point of reliability through their management of the Centaur Program. This paper demonstrates how the personality and engineering intuition of Abe Silverstein shaped the Centaur program and left a lasting imprint on the laboratory research tradition. Many of the current leaders of Lewis Research Center received their first hands-on engineering experience when they worked on the Centaur program in the 1960s.

  4. UPDATE ON DEMENTIA WITH LEWY BODIES

    PubMed Central

    Karantzoulis, Stella; Galvin, James E.

    2014-01-01

    Dementia with Lewy bodies (DLB) is the second most common form of dementia after Alzheimer disease (AD). DLB is characterized pathologically by Lewy body and Lewy neuritic pathology, often with variable levels of Alzheimer-type pathology. Core clinical features include fluctuating cognition, visual hallucinations, and parkinsonism resulting in greater impairments of quality of life, more caregiver burden, and higher health-related costs compared with AD. These issues, together with a high sensitivity to adverse events with treatment with antipsychotic agents, make the need for an early and accurate diagnosis of DLB essential. Unfortunately, current consensus criteria are highly specific but lack sufficient sensitivity. Use of composite risk scores may improve accuracy of clinical diagnosis. Imaging findings, particularly targeting dopaminergic systems have shown promise as potential markers to differentiate DLB from AD. A combination of non-pharmacologic treatments and pharmacotherapy interventions may maximize cognitive function and overall quality of life in DLB patients. PMID:25379359

  5. NASA Lewis Wind Tunnel Model Systems Criteria

    NASA Technical Reports Server (NTRS)

    Soeder, Ronald H.; Haller, Henry C.

    1994-01-01

    This report describes criteria for the design, analysis, quality assurance, and documentation of models or test articles that are to be tested in the aeropropulsion facilities at the NASA Lewis Research Center. The report presents three methods for computing model allowable stresses on the basis of the yield stress or ultimate stress, and it gives quality assurance criteria for models tested in Lewis' aeropropulsion facilities. Both customer-furnished model systems and in-house model systems are discussed. The functions of the facility manager, project engineer, operations engineer, research engineer, and facility electrical engineer are defined. The format for pretest meetings, prerun safety meetings, and the model criteria review are outlined Then, the format for the model systems report (a requirement for each model that is to be tested at NASA Lewis) is described, the engineers that are responsible for developing the model systems report are listed, and the time table for its delivery to the facility manager is given.

  6. The man who loved flies: a biographical profile of Nelson Papavero .

    PubMed

    Klassa, Bruna; Santos, Charles Morphy D

    2014-01-01

    Nelson Papavero is one of the major Brazilian zoologists. His contribution to the field began in the second half of the twentieth century, when he started publishing in the areas of entomology, systematics, biogeography, and history of science, while working at graduate courses and training teachers and students. Papavero was one of the earliest Brazilian advocates of Hennig's phylogenetic systematics. In his entomological work, his first widely recognised works were the Catalogue of South American Diptera and his essays on the history of Neotropical Dipterology. Papavero's greatest contribution however, is in his Special Courses on Zoological Systematics, as well as his numerous administrative positions during his academic career. All these were fundamental to the development of zoology and comparative biology in Brazil and other Latin American countries. Here we present a biography of Nelson Papavero, along with several personal anecdotes, and his role in the development of Brazilian biological systematics over the last 50 years.  PMID:24870161

  7. A Lewis acid-promoted Pinner reaction

    PubMed Central

    Pfaff, Dominik; Nemecek, Gregor

    2013-01-01

    Summary Carbonitriles and alcohols react in a Lewis acid-promoted Pinner reaction to carboxylic esters. Best results are obtained with two equivalents of trimethylsilyl triflate as Lewis acid. Good yields are achieved with primary alcohols and aliphatic or benzylic carbonitriles, but the straightforward synthesis of acrylates and benzoates starting with acrylonitrile and benzonitrile, respectively, is similarly possible. Phenols are not acylated under these reaction conditions. The method has been used for the first total synthesis of the natural product monaspilosin. In the reaction of benzyl alcohols variable amounts of amides are formed in a Ritter-type side reaction. PMID:23946857

  8. Lewis hybrid computing system, users manual

    NASA Technical Reports Server (NTRS)

    Bruton, W. M.; Cwynar, D. S.

    1979-01-01

    The Lewis Research Center's Hybrid Simulation Lab contains a collection of analog, digital, and hybrid (combined analog and digital) computing equipment suitable for the dynamic simulation and analysis of complex systems. This report is intended as a guide to users of these computing systems. The report describes the available equipment' and outlines procedures for its use. Particular is given to the operation of the PACER 100 digital processor. System software to accomplish the usual digital tasks such as compiling, editing, etc. and Lewis-developed special purpose software are described.

  9. Synthesis and Lewis acidity of fluorophosphonium cations.

    PubMed

    Caputo, Christopher B; Winkelhaus, Daniel; Dobrovetsky, Roman; Hounjet, Lindsay J; Stephan, Douglas W

    2015-07-21

    A series of fluorophosphonium salts, [R3PF][X] (R = alkyl or aryl; X = FB(C6F5)3, [B(C6F5)4]), have been prepared by reactions of phosphine/borane frustrated Lewis pairs (FLPs) with XeF2 or difluorophosphoranes with [Et3Si][B(C6F5)4]. As the substituents bound to phosphorus become increasingly electron withdrawing, the corresponding fluorophosphonium salts are shown to be increasingly Lewis acidic. Calculations were also performed to determine the relative fluoride ion affinities (FIA) of these fluorophosphonium cations. PMID:25785571

  10. Positron Emission Tomography-Computed Tomography Coregistration for Diagnosis and Intraoperative Localization in Recurrent Nelson Syndrome

    PubMed Central

    Hintz, Eric B.; Tomlin, Jeffery M.; Chengazi, Vaseem; Vates, G. Edward

    2013-01-01

    Recurrent pituitary disease presents unique challenges, including in some cases difficulty localizing a tumor radiographically. Here, we present the case of a patient with recurrent Nelson syndrome whose radiographic work-up was complicated by a significant parasellar metallic artifact. Positron emission tomography ultimately localized the lesion, and coregistration with computed tomography allowed for accurate intraoperative navigation. Additionally, we review a range of imaging techniques available in the evaluation of pituitary disease. PMID:23943718

  11. STS-26 MS Nelson during training exercise in JSC Mockup and Integration Lab

    NASA Technical Reports Server (NTRS)

    1988-01-01

    STS-26 Discovery, Orbiter Vehicle (OV) 103, Mission Specialist (MS) George D. Nelson, wearing navy blue launch and entry suit (LES) and launch and entry helmet (LEH), is seated in his launch and entry position on crew compartment trainer (CCT) middeck during a training exercise in JSC Mockup and Integration Laboratory Bldg 9A. Visible in the background are the airlock, stowed treadmill, and sleep restraints. NOTE: Photo was taken by William H. Bowers, crew photo instructor, with wide angle lens.

  12. In dementia with Lewy bodies, Braak stage determines phenotype, not Lewy body distribution.

    PubMed

    Weisman, D; Cho, M; Taylor, C; Adame, A; Thal, L J; Hansen, L A

    2007-07-24

    We used an autopsy series to determine whether the newest dementia with Lewy bodies (DLB) consensus pathologic classification correlates with premortem diagnosis of DLB. Neocortical sections from a total of 95 cases with Lewy bodies were stained with alpha-synuclein antibodies. We assigned cases according to the DLB consensus' categories and found a significant association with the premortem clinical diagnosis of DLB. Clinical diagnosis of DLB, however, depended on the presence of low Alzheimer disease pathology (by Braak staging) rather than on Lewy body distribution. PMID:17646627

  13. Lewy Body Dementia: Information for Patients, Families, and Professionals

    MedlinePlus

    ... About ADEAR Lewy Body Dementia: Information for Patients, Families, and Professionals Introduction Lewy body dementia mostly affects ... find a cure—people with LBD and their families struggle day to day to get an accurate ...

  14. Effects of the Oxygen-Carrying Solution OxyVita C on the Cerebral Microcirculation and Systemic Blood Pressures in Healthy Rats

    PubMed Central

    Abutarboush, Rania; Aligbe, Chioma; Pappas, Georgina; Saha, Biswajit; Arnaud, Francoise; Haque, Ashraful; Auker, Charles; McCarron, Richard; Scultetus, Anke; Moon-Massat, Paula

    2014-01-01

    The use of hemoglobin-based oxygen carriers (HBOC) as oxygen delivering therapies during hypoxic states has been hindered by vasoconstrictive side effects caused by depletion of nitric oxide (NO). OxyVita C is a promising oxygen-carrying solution that consists of a zero-linked hemoglobin polymer with a high molecular weight (~17 MDa). The large molecular weight is believed to prevent extravasation and limit NO scavenging and vasoconstriction. The aim of this study was to assess vasoactive effects of OxyVita C on systemic blood pressures and cerebral pial arteriole diameters. Anesthetized healthy rats received four intravenous (IV) infusions of an increasing dose of OxyVita C (2, 25, 50, 100 mg/kg) and hemodynamic parameters and pial arteriolar diameters were measured pre- and post-infusion. Normal saline was used as a volume-matched control. Systemic blood pressures increased (P ≤ 0.05) with increasing doses of OxyVita C, but not with saline. There was no vasoconstriction in small (<50 µm) and medium-sized (50–100 µm) pial arterioles in the OxyVita C group. In contrast, small and medium-sized pial arterioles vasoconstricted in the control group. Compared to saline, OxyVita C showed no cerebral vasoconstriction after any of the four doses evaluated in this rat model despite increases in blood pressure. PMID:25411852

  15. Lewis Carroll's Formula for Calendar Calculating.

    ERIC Educational Resources Information Center

    Spitz, Herman H.

    1993-01-01

    This paper presents Lewis Carroll's formula for mentally calculating the day of the week of a given date. The paper concludes that such formulas are too complex for individuals of low intelligence to learn by themselves, and thus "idiots savants" who perform such calendar calculations must be using other systems. (JDD)

  16. Celebrating the Bicentennial of Lewis and Clark

    ERIC Educational Resources Information Center

    Morris, Ronald V.; McNeely, Jean

    2005-01-01

    Lewis, Clark, and the Corps of Discovery traveled westward from 1803 to 1806; therefore, the bicentennial of the expedition is being celebrated from 2003 until 2006. Students and teachers celebrating the bicentennial and Jefferson's Louisiana Purchase in 1803 can use social studies classes to help them connect with their community and to reach a…

  17. Playing around in Lewis Carroll's "Alice" Books

    ERIC Educational Resources Information Center

    Susina, Jan

    2010-01-01

    Mathematician Charles Dodgson's love of play and his need for rules came together in his use of popular games as part of the structure of the two famous children's books, "Alice in Wonderland" and "Through the Looking-Glass," he wrote under the pseudonym Lewis Carroll. The author of this article looks at the interplay between…

  18. Lewis Thomas and droopy rabbit ears

    PubMed Central

    Bashyam, Hema

    2007-01-01

    In 1956, Lewis Thomas discovered that injecting rabbits with a plant protease called papain caused their ears to collapse. This experiment led to the identification of the endogenous proteases that cause the tissue destruction seen in diseases such as rheumatoid arthritis.

  19. Teaching a Model for Writing Lewis Structures.

    ERIC Educational Resources Information Center

    Pardo, Juan Quilez

    1989-01-01

    Presents a didactic model to improve the teaching/learning process in the representation of Lewis structures. Places special emphasis on the calculation and reduction of formal charges, and in the representation of molecules in which the central atom has expanded its valence shell. (MVL)

  20. Composites research at NASA Lewis Research Center

    NASA Technical Reports Server (NTRS)

    Levine, Stanley R.; Duffy, Stephen; Vary, Alex; Nathal, Michael V.; Miner, Robert V.; Arnold, Steven M.; Castelli, Michael G.; Hopkins, Dale A.; Meador, Michael A.

    1994-01-01

    Composites research at NASA Lewis is focused on their applications in aircraft propulsion, space propulsion, and space power, with the first being predominant. Research on polymer-, metal-, and ceramic-matrix composites is being carried out from an integrated materials and structures viewpoint. This paper outlines some of the topics being pursued from the standpoint of key technical issues, current status, and future directions.

  1. Learning To Reason from Lewis Carroll.

    ERIC Educational Resources Information Center

    Rothbart, Andrea

    1998-01-01

    Discusses the process and the usefulness of translating empirical logic puzzles into mathematical problems which may be more easily solved, then translating the answer back into the context of the original problem. Presents nine logic puzzles devised by Lewis Carroll, with answers. (AIM)

  2. Reply to Tone Kvernbekk and Ann Lewis

    ERIC Educational Resources Information Center

    Tangen, Reidun

    2008-01-01

    The purpose of this reply to Kvernbekk and Lewis's comments regarding the discussion on epistemological and ethical problems of listening to children's voices, is not to propose a coherent foundation free from any epistemological tensions. Rather, Tangen's intent is primarily to explore different perspectives in order to disclose some of their…

  3. Celebrating the Bicentennial of Lewis and Clark

    ERIC Educational Resources Information Center

    Morris, Ronald V.; McNeely, Jean

    2005-01-01

    Lewis, Clark, and the Corps of Discovery traveled westward from 1803 to 1806; therefore, the bicentennial of the expedition is being celebrated from 2003 until 2006. Students and teachers celebrating the bicentennial and Jefferson's Louisiana Purchase in 1803 can use social studies classes to help them connect with their community and to reach a

  4. Lewis and Clark--Indiana Connections.

    ERIC Educational Resources Information Center

    Bennett, Pamela J., Ed.

    2003-01-01

    The state of Indiana has an important, recognized connection to the Lewis and Clark Expedition. That connection is reinforced with a National Signature Event in Clarksville (Indiana) during October 2003. Until the expedition party left its winter camp in May 1804, it remained in Indiana Territory, governed from Vincennes (Indiana) by William Henry…

  5. An Overview of Lewis Basicity and Affinity Scales

    ERIC Educational Resources Information Center

    Laurence, Christian; Graton, Jerome; Gal, Jean-Francois

    2011-01-01

    The impossibility of establishing a universal scale of Lewis basicity does not prevent the determination of the quantitative behavior of Lewis bases, thanks to scales constructed against particular Lewis acids: BF[subscript 3], 4-FC[subscript 6]H[subscript 4]OH, I[subscript 2], Li[superscript +], Na[superscript +], K[superscript +], Al[superscript…

  6. An Overview of Lewis Basicity and Affinity Scales

    ERIC Educational Resources Information Center

    Laurence, Christian; Graton, Jerome; Gal, Jean-Francois

    2011-01-01

    The impossibility of establishing a universal scale of Lewis basicity does not prevent the determination of the quantitative behavior of Lewis bases, thanks to scales constructed against particular Lewis acids: BF[subscript 3], 4-FC[subscript 6]H[subscript 4]OH, I[subscript 2], Li[superscript +], Na[superscript +], K[superscript +], Al[superscript

  7. Teaching Beginning Chemistry Students Simple Lewis Dot Structures

    ERIC Educational Resources Information Center

    Nassiff, Peter; Czerwinski, Wendy A.

    2015-01-01

    Students beginning their initial study of chemistry often have a difficult time mastering simple Lewis dot structures. Textbooks show students how to manipulate Lewis structures by moving valence electron dots around the chemical structure so each atom has an octet or duet. However, an easier method of teaching Lewis structures for simple…

  8. Teaching Beginning Chemistry Students Simple Lewis Dot Structures

    ERIC Educational Resources Information Center

    Nassiff, Peter; Czerwinski, Wendy A.

    2015-01-01

    Students beginning their initial study of chemistry often have a difficult time mastering simple Lewis dot structures. Textbooks show students how to manipulate Lewis structures by moving valence electron dots around the chemical structure so each atom has an octet or duet. However, an easier method of teaching Lewis structures for simple

  9. Getting the Weights of Lewis Structures out of Huckel Theory: Huckel-Lewis Configuration Interaction (HL-CI)

    ERIC Educational Resources Information Center

    Humbel, Stephane

    2007-01-01

    A simple method is proposed based on energies obtained with the Huckel theory to compute the weights of the structures. The Huckel-Lewis CI technique extends to the Huckel theory the field of the resonance between Lewis structures.

  10. "Inverse" Frustrated Lewis Pairs - Activation of Dihydrogen with Organosuperbases and Moderate to Weak Lewis Acids.

    PubMed

    Mummadi, Suresh; Unruh, Daniel K; Zhao, Jiyang; Li, Shuhua; Krempner, Clemens

    2016-03-16

    A new approach to intermolecular frustrated Lewis pairs (FLPs) that combines readily available bulky organosuperbases with moderate to weak boron-containing Lewis acids is reported. These so-called "inverse" FLPs are demonstrated to heterolytically cleave dihydrogen, allowing for the isolation and structural characterization of various phosphonium borohydride salts; two FLPs proved to be efficient catalyst's in the metal-free hydrogenation of N-benzylidenaniline. PMID:26899711

  11. Thuja occidentalis (Arbor vitae): A Review of its Pharmaceutical, Pharmacological and Clinical Properties

    PubMed Central

    2005-01-01

    Arbor vitae (Thuja occidentalis L.) is a native European tree widely used in homeopathy and evidence-based phytotherapy. Many reviews and monographs have been published on the herbal substance's description, mode of action and clinical use. However, no comprehensive evidence-based review is available. Therefore, our aim was to search MEDLINE databases and survey manufacturers for further details or unpublished data. This review presents the botany, ethnobotany and phytochemistry, especially the different contents of essential oil (Thujone) in relation to different extraction procedures of this medicinal plant. Thuja's antiviral action and immunopharmacological potential, such as stimulatory and co-stimulatory effects on cytokine and antibody production and activation of macrophages and other immunocompetent cells, have been evaluated in numerous in vitro and in vivo investigations. Although no controlled trials have been conducted on Thuja occ alone, many clinical studies have been performed with a herbal medicinal product containing a special extract of Thuja occ and other immunostimulants, demonstrating its therapeutic efficacy and safety in respiratory tract infections. PMID:15841280

  12. Modern Exploration of the Lewis and Clark Expedition

    NASA Technical Reports Server (NTRS)

    2006-01-01

    The Lewis and Clark Geosystem is an online collection of private, state, local, and Federal data resources associated with the geography of the Lewis and Clark Expedition. Data were compiled from key partners including NASA s Stennis Space Center, the U.S. Army Corps of Engineers, the U.S. Fish and Wildlife Service, the U.S. Geological Survey (USGS), the University of Montana, the U.S. Department of Agriculture Forest Service, and from a collection of Lewis and Clark scholars. It combines modern views of the landscape with historical aerial photography, cartography, and other geographical data resources and historical sources, including: The Journals of the Lewis and Clark Expedition, the Academy of Natural Science's Lewis and Clark Herbarium, high-resolution copies of the American Philosophical Society s primary-source Lewis and Clark Journals, The Library of Congress Lewis and Clark cartography collection, as well as artifacts from the Smithsonian Institution and other sources.

  13. A Biography of Distinguished Scientist Gilbert Newton Lewis (by Edward S. Lewis)

    NASA Astrophysics Data System (ADS)

    Harris, Reviewed By Harold H.

    1999-11-01

    The Edward Mellen Press: Lewiston, NY, 1998. 114 pp + index. ISBN 0-7734-8284-9. $69.95. There may not be a surname better known to students of chemistry than Lewis, from the Lewis electron-dot diagrams and the Lewis theory of acids and bases. More advanced students may know of the groundbreaking textbook Thermodynamics, by Lewis and Randall. Yet few Americans know much about this remarkable U.S.-born scholar, whose contributions equal those of the greatest scientists. He is a chemist-educator of whom we should be as proud and as well informed as we are of Linus Pauling, who was part of the westward movement of science in this country that G. N. Lewis began, or of the recently deceased Glenn Seaborg, who was one of the many students of Lewis who achieved renown. Gilbert N. Lewis was born in Weymouth, Massachusetts, in 1875, but his family moved to near Lincoln, Nebraska, in 1884. He spent two years at the University of Nebraska, but then moved to Harvard when his father became an executive at Merchants Trust Company in Boston. Young Lewis (then only 17) was also said to have been disappointed with the quality of education in Nebraska, and this may have been part of the impetus for the family's move east. After earning his baccalaureate at Harvard, he taught for a year at Phillips Andover Academy before returning to Harvard to study for his doctorate, which he completed 100 years ago, in 1899, under T. W. Richards. Lewis's doctoral work was on the thermodynamics of zinc and cadmium amalgams. At that time, physical chemistry was only beginning to achieve recognition as a branch of science, and its boundaries were ill defined. Edward Lewis quotes his father as often saying, "Physical chemistry is anything interesting." Like many chemists of his time, Lewis went to Europe to complete his preparation for a career; he was in the laboratories of Ostwald in Leipzig and Nernst in Göttingen in 1900-1901. On his return to the United States, he was an instructor at Harvard until 1904, when he accepted a position that would not be considered a shrewd career move: Superintendent of Weights and Measures in Manila, Philippines! He was there only one year, but it was apparently a productive time, both in a minimally equipped laboratory and with the possible nascence of some of his ideas about bonding. In 1905, Lewis accepted a staff position at MIT, under A. A. Noyes, where he remained until 1912. At MIT, he continued his experimental work on thermodynamic systems and the development of modern thermodynamics, following the lead of J. W. Gibbs, whose work was being largely ignored by other chemists. As Noyes moved increasingly into administrative responsibilities, Lewis took over more and more of the supervision of scientific work in the laboratory. It was the capable job that he did for Noyes that led to his being offered a Professorship and Chair of the College of Chemistry at the University of California, Berkeley. The same spirit of adventure that took Lewis to Manila may be what led to his moving to scientifically backward California. In 1912, there was no serious science going on the Left Coast, and Berkeley was isolated from the nearest civilization (Chicago) by days of travel. Lewis initiated the expansion of great science westward, not only to Berkeley, but also to Caltech (in those days Throop Institute), UCLA, and Stanford. By dint of his contributions to thermodynamics and bonding theory (suggesting that electrons bond in pairs, long before there was quantum mechanical justification for such a strange idea), and his organizational and leadership talents, he turned the Berkeley Chemistry Department from a nonentity into one of the finest anywhere. Later in his career, he contributed to the understanding of the role of isotopes in chemistry and physics. This biography includes a useful listing of Lewis's 168 scientific publications. In an age when many renowned scientists have multiples of this number, it is perhaps good to be reminded that quality counts, too. His story deserves much greater recognition (he should have won a Nobel of his own) and I am happy to see the appearance of this biography. On the other hand, it is unfortunate that a better book did not result from the author's heartfelt best intentions. Edward Lewis covers his father's career in barely over 100 pages of uninspiring prose. Ten percent of that is wasted in printing letters from famous scientists, many of them Lewis's students and Nobel laureates, endorsing the greatness of their colleague. Even the title of the book is off-putting: if the subject of a biography is "distinguished", it should not be necessary to make the claim in the title. I also wonder at the price of this slim volume. In the more than fifty years since Lewis died in 1946, nearly all of his students have also died. Even his chemist son had difficulty in finding contemporaries of his father who could provide recollections and original material for the history. The best of his sources is this Journal, which published in January-March issues of 1984 the proceedings of a symposium on the life and work of G. N. Lewis that had been held March 30-31, 1982, in Las Vegas. I recommend those papers, by Derek Davenport, Richard Lewis (G. N.'s other chemist son), John Servos, Melvin Calvin, Glenn Seaborg, Gerald Branch, Leo Brewer, Kenneth Pitzer, Jacob Bigeleisen, Anthony Stranges, Linus Pauling, William Jensen, and Michael Kasha.

  14. Fuels research studies at NASA Lewis

    NASA Technical Reports Server (NTRS)

    Antoine, A. C.

    1982-01-01

    Fuels research studies carried out in a variety of areas related to aviation propulsion, ground transportation, and stationary power generation systems are discussed. The major efforts are directed to studies on fuels for jet aircraft. These studies involve fuels preparation, fuels analysis, and fuel quality evaluations. The scope and direction of research activities in these areas is discussed, descriptions of Lewis capabilities and facilities given, and results of recent research efforts reported.

  15. NASA Lewis' IITA K-12 Program

    NASA Technical Reports Server (NTRS)

    1996-01-01

    The NASA Lewis Research Center's Information Infrastructure Technology and Applications for Kindergarten to 12th Grade (IITA K-12) Program is designed to introduce into school systems computing and communications technology that benefits math and science studies. By incorporating this technology into K-12 curriculums, we hope to increase the proficiency and interest in math and science subjects by K-12 students so that they continue to study technical subjects after their high school careers are over.

  16. Patient advocacy by rural emergency physicians after major service cuts: the case of Nelson, BC.

    PubMed

    Fleet, Richard; Plant, Jeff; Ness, Rhonda; Moola, Shiraz

    2013-01-01

    Efforts at cost containment through regionalization have led to reduced services in several rural emergency departments (EDs) in Canada. As a result, questions have been raised about patient safety and equitable access to care, compelling physicians to advocate for their patients. Few published reports on physicians' advocacy experiences pertaining to rural EDs exist. We describe our experience of patient advocacy after major service cuts at Kootenay Lake Hospital in Nelson, BC. Despite mixed results, we suggest increased physician involvement in patient advocacy. PMID:23566863

  17. Scaling Limit for a Generalization of the Nelson Model and its Application to Nuclear Physics

    NASA Astrophysics Data System (ADS)

    Suzuki, Akito

    We study a mathematically rigorous derivation of a quantum mechanical Hamiltonian in a general framework. We derive such a Hamiltonian by taking a scaling limit for a generalization of the Nelson model, which is an abstract interaction model between particles and a Bose field with some internal degrees of freedom. Applying it to a model for the field of the nuclear force with isospins, we obtain a Schrödinger Hamiltonian with a matrix-valued potential, the one pion exchange potential, describing an effective interaction between nucleons.

  18. STS-26 MS Nelson operates controls for PVTOS-2 experiment on aft middeck

    NASA Technical Reports Server (NTRS)

    1988-01-01

    STS-26 Mission Specialist (MS) George D. Nelson operates generic electronics module for the Physical Vapor Transport of Organic Solids 2 (PVTOS-2) experiment on Discovery's, Orbiter Vehicle (OV) 103's, aft middeck. PVTOS-2 consists of nine independent experimental cells about 12 inches long and 3 inches in diameter. They are mounted in a circular base plate inside the drum-like experimental apparatus container (EAC). PVTOS-2 is sponsored by NASA's Office of Commercial Programs and is being conducted by 3M's Space Research and Applications Laboratory.

  19. Lewis Information Network (LINK): Background and overview

    NASA Technical Reports Server (NTRS)

    Schulte, Roger R.

    1987-01-01

    The NASA Lewis Research Center supports many research facilities with many isolated buildings, including wind tunnels, test cells, and research laboratories. These facilities are all located on a 350 acre campus adjacent to the Cleveland Hopkins Airport. The function of NASA-Lewis is to do basic and applied research in all areas of aeronautics, fluid mechanics, materials and structures, space propulsion, and energy systems. These functions require a great variety of remote high speed, high volume data communications for computing and interactive graphic capabilities. In addition, new requirements for local distribution of intercenter video teleconferencing and data communications via satellite have developed. To address these and future communications requirements for the next 15 yrs, a project team was organized to design and implement a new high speed communication system that would handle both data and video information in a common lab-wide Local Area Network. The project team selected cable television broadband coaxial cable technology as the communications medium and first installation of in-ground cable began in the summer of 1980. The Lewis Information Network (LINK) became operational in August 1982 and has become the backbone of all data communications and video.

  20. Lewis' Educational and Research Collaborative Internship Program

    NASA Technical Reports Server (NTRS)

    Heyward, Ann; Gott, Susan (Technical Monitor)

    2004-01-01

    The Lewis Educational and Research Collaborative Internship Program (LERCIP) is a collaborative undertaking by the Office of Educational Programs at NASA Glenn Research Center at Lewis Field (formerly NASA Lewis Research Center) and the Ohio Aerospace Institute. This program provides 10-week internships in addition to summer and winter extensions if funding is available and/or is requested by mentor (no less than 1 week no more than 4 weeks) for undergraduate/graduate students and secondary school teachers. Students who meet the travel reimbursement criteria receive up to $500 for travel expenses. Approximately 178 interns are selected to participate in this program each year and begin arriving the fourth week in May. The internships provide students with introductory professional experiences to complement their academic programs. The interns are given assignments on research and development projects under the personal guidance of NASA professional staff members. Each intern is assigned a NASA mentor who facilitates a research assignment. In addition to the research assignment, the summer program includes a strong educational component that enhances the professional stature of the participants. The educational activities include a research symposium and a variety of workshops, and lectures. An important aspect of the program is that it includes students with diverse social, cultural and economic backgrounds. The purpose of this report is to document the program accomplishments for 2004.

  1. Dual Lewis Acid/Lewis Base Catalyzed Acylcyanation of Aldehydes: A Mechanistic Study.

    PubMed

    Laurell Nash, Anna; Hertzberg, Robin; Wen, Ye-Qian; Dahlgren, Björn; Brinck, Tore; Moberg, Christina

    2016-03-01

    A mechanistic investigation, which included a Hammett correlation analysis, evaluation of the effect of variation of catalyst composition, and low-temperature NMR spectroscopy studies, of the Lewis acid-Lewis base catalyzed addition of acetyl cyanide to prochiral aldehydes provides support for a reaction route that involves Lewis base activation of the acyl cyanide with formation of a potent acylating agent and cyanide ion. The cyanide ion adds to the carbonyl group of the Lewis acid activated aldehyde. O-Acylation by the acylated Lewis base to form the final cyanohydrin ester occurs prior to decomplexation from titanium. For less reactive aldehydes, the addition of cyanide is the rate-determining step, whereas, for more reactive, electron-deficient aldehydes, cyanide addition is rapid and reversible and is followed by rate-limiting acylation. The resting state of the catalyst lies outside the catalytic cycle and is believed to be a monomeric titanium complex with two alcoholate ligands, which only slowly converts into the product. PMID:26592522

  2. Frustrated Lewis pairs: from concept to catalysis.

    PubMed

    Stephan, Douglas W

    2015-02-17

    CONSPECTUS: Frustrated Lewis pair (FLP) chemistry has emerged in the past decade as a strategy that enables main-group compounds to activate small molecules. This concept is based on the notion that combinations of Lewis acids and bases that are sterically prevented from forming classical Lewis acid-base adducts have Lewis acidity and basicity available for interaction with a third molecule. This concept has been applied to stoichiometric reactivity and then extended to catalysis. This Account describes three examples of such developments: hydrogenation, hydroamination, and CO2 reduction. The most dramatic finding from FLP chemistry was the discovery that FLPs can activate H2, thus countering the long-existing dogma that metals are required for such activation. This finding of stoichiometric reactivity was subsequently evolved to employ simple main-group species as catalysts in hydrogenations. While the initial studies focused on imines, subsequent studies uncovered FLP catalysts for a variety of organic substrates, including enamines, silyl enol ethers, olefins, and alkynes. Moreover, FLP reductions of aromatic anilines and N-heterocycles have been developed, while very recent extensions have uncovered the utility of FLP catalysts for ketone reductions. FLPs have also been shown to undergo stoichiometric reactivity with terminal alkynes. Typically, either deprotonation or FLP addition reaction products are observed, depending largely on the basicity of the Lewis base. While a variety of acid/base combinations have been exploited to afford a variety of zwitterionic products, this reactivity can also be extended to catalysis. When secondary aryl amines are employed, hydroamination of alkynes can be performed catalytically, providing a facile, metal-free route to enamines. In a similar fashion, initial studies of FLPs with CO2 demonstrated their ability to capture this greenhouse gas. Again, modification of the constituents of the FLP led to the discovery of reaction systems that demonstrated stoichiometric reduction of CO2 to either methanol or CO. Further modification led to the development of catalytic systems for the reduction of CO2 by hydrosilylation and hydroboration or deoxygenation. As each of these areas of FLP chemistry has advanced from the observation of unusual stoichiometric reactions to catalytic processes, it is clear that the concept of FLPs provides a new strategy for the design and application of main-group chemistry and the development of new metal-free catalytic processes. PMID:25535796

  3. Purification and characterization of Lewy bodies from the brains of patients with diffuse Lewy body disease.

    PubMed Central

    Iwatsubo, T.; Yamaguchi, H.; Fujimuro, M.; Yokosawa, H.; Ihara, Y.; Trojanowski, J. Q.; Lee, V. M.

    1996-01-01

    Lewy bodies (LBs) are the pathological hallmarks of degenerating neurons in the brains of patients with Parkinson's disease and diffuse Lewy body disease. We developed a novel purification procedure for LBs using sucrose density separation followed by fluorescence-activated particle sorting, and we raised > 15 monoclonal antibodies to LBs purified from diffuse Lewy body disease brains. The monoclonal antibody that stained the largest number of LBs most intensely did not recognize ubiquitin in free or monoubiquitinated forms nor the ubiquitin conjugating enzymes, but it did react with polyubiquitin chains as well as with high molecular weight polyubiquitinated LB-derived proteins. Thus, these results suggest that LBs contain polyubiquitin chains. Although polyubiquitination of LB proteins may trigger ubiquitin-proteasome proteolytic pathways, the incomplete activation of these pathways could play a mechanistic role in the formation of LBs in neurodegenerative diseases. Images Figure 3 Figure 2 Figure 4 Figure 5 Figure 6 PMID:8623921

  4. A "three-in-one" sample preparation method for simultaneous determination of B-group water-soluble vitamins in infant formula using VitaFast(®) kits.

    PubMed

    Zhang, Heng; Lan, Fang; Shi, Yupeng; Wan, Zhi-Gang; Yue, Zhen-Feng; Fan, Fang; Lin, Yan-Kui; Tang, Mu-Jin; Lv, Jing-Zhang; Xiao, Tan; Yi, Changqing

    2014-06-15

    VitaFast(®) test kits designed for the microbiological assay in microtiter plate format can be applied to quantitative determination of B-group water-soluble vitamins such as vitamin B12, folic acid and biotin, et al. Compared to traditional microbiological methods, VitaFast(®) kits significantly reduce sample processing time and provide greater reliability, higher productivity and better accuracy. Recently, simultaneous determination of vitamin B12, folic acid and biotin in one sample is urgently required when evaluating the quality of infant formulae in our practical work. However, the present sample preparation protocols which are developed for individual test systems, are incompatible with simultaneous determination of several analytes. To solve this problem, a novel "three-in-one" sample preparation method is herein developed for simultaneous determination of B-group water-soluble vitamins using VitaFast(®) kits. The performance of this novel "three-in-one" sample preparation method was systematically evaluated through comparing with individual sample preparation protocols. The experimental results of the assays which employed "three-in-one" sample preparation method were in good agreement with those obtained from conventional VitaFast(®) extraction methods, indicating that the proposed "three-in-one" sample preparation method is applicable to the present three VitaFast(®) vitamin test systems, thus offering a promising alternative for the three independent sample preparation methods. The proposed new sample preparation method will significantly improve the efficiency of infant formulae inspection. PMID:24491742

  5. Development and validation of detailed controls models of the Nelson River Bipole 1 HVDC system

    SciTech Connect

    Kuffel, P.; Kent, K.L.; Mazur, G.B.; Weekes, M.A. )

    1993-01-01

    With the Nelson River Bipole 1 mercury arc valve group replacement project and planning for the expansion of the Nelson River HVDC system with a third bipole underway, it was decided to pursue a program to develop and validate detailed models of the existing HVDC transmission facilities and their associated ac systems for use in system studies. The first phase of the program concentrated on the development of detailed controls models associated with the Bipole 1 transmission facility. Based on previous experience at Manitoba Hydro with the Electromagnetic Transient DC simulation program (EMTDC), it was decided that model development and validation would use this program. This paper presents the reasons behind the development of detailed models, the methods used in developing models related to Bipole 1, results of validation tests, difficulties encountered during the process, and the overall benefits resulting from the project. An example of applying the models to investigate a low frequency oscillation which has occurred on the dc system in the past is also presented.

  6. Identifying Hydrological Controls in the Lower Nelson River Basin utilizing Stable Water Isotopes

    NASA Astrophysics Data System (ADS)

    Delavau, C. J.; Smith, A. A.; Stadnyk, T.; Koenig, K.

    2012-12-01

    In 2010 a Stable Water Isotope (SWI) Monitoring Network was established within the lower Nelson River Basin (LNRB) (approximately 90,000 km2) in northern Manitoba, Canada, through a joint collaboration between the University of Manitoba and Manitoba Hydro (MH). The monitoring network encompasses over 60 sites where surface waters are regularly sampled, four sites sampling isotopes in precipitation, two sites utilizing drive point piezometers for the isotopic sampling of baseflow waters, and one site collecting evaporatively enriched water samples from an evaporation pan. In addition, two synoptic surveys have been completed in June 2011 and July 2012 to obtain annual snapshots of the monitoring network at a point in time. Currently, over 700 samples have been collected and analyzed. The LNRB contains approximately 9% of the total Nelson River Basin (NRB) drainage area, which encompasses an area of over 1 million km2. A diversion from the Churchill River through the Rat/Burntwood system routes an additional portion of flow into the northwest portion of the LNRB. The LNRB is significant to MH's network as it represents 75% of their power generation potential through six generating stations, thus resulting in a large portion of the basin being regulated. The watershed is topographically flat, therefore the movement and runoff of water, as well as isotopic composition of streamflow, is suspected to be highly impacted by changes in landscape and hydrography. The LNRB is a coniferous and wetland dominated basin, with almost 35% of the land cover composed of coniferous forest and 40% comprised of wetlands and lakes. Interpretation of the LNRB isotope framework shows that the major water sources (rainfall, snowfall, groundwater and surface waters) and rivers are isotopically distinct from one another. The main stem of the Nelson River shows little spatial or temporal variability, with an average δ18O of -10.6‰ and a standard deviation of 0.5‰ throughout the sampling period. Conversely, the main stem of the Burntwood River system shows increased variability relative to the Nelson River and overall is more depleted (average δ18O of -12.9‰ and a standard deviation of 0.75‰). Many of the headwater tributaries to the Nelson and Burntwood River systems such as Birchtree Brook, and the Minago, Gunisao, Grass, Odei, Footprint and Sapochi Rivers show large temporal and spatial variability due to relatively smaller drainage areas and differences in typology and connectivity. For this reason, further investigation into the correlation of land cover with isotopic composition is assessed for the aforementioned tributaries to better establish the hydrological controls (i.e., sources and sinks) for each sub-basin at the mesoscale. Results signify a strong relationship between percent wetland coverage and the slope of the Local Evaporation Line (SLEL) for headwater sub-basins (R2=0.99), indicating the likelihood of enhanced evaporative enrichment for sub-basins with increased wetland coverage. The collection of SWI's within the LNRB will help to develop a comprehensive understanding of water sources and cycling in this basin with the end goal of improving hydrological forecasting tools to predict, with improved certainty, future water availability for hydroelectric power production.

  7. Vita-Assay Method of Enrichment and Identification of Circulating Cancer Cells/Circulating Tumor Cells (CTCs).

    PubMed

    Tulley, Shaun; Zhao, Qiang; Dong, Huan; Pearl, Michael L; Chen, Wen-Tien

    2016-01-01

    The ability to capture, enrich, and propagate circulating cancer cells/circulating tumor cells (CTCs) for downstream analyses such as ex vivo drug-sensitivity testing of short-term cultures of CTCs, single cell sorting of CTCs by fluorescence activated cell sorting (FACS), animal injection tumor and/or metastasis formation studies, next generation sequencing (NGS), gene expression profiling, gene copy number determination, and epigenomic analyses is of high priority and of immense importance to both the basic research and translational/clinical research communities. Vitatex Inc.'s functional cell separation technology, constructed as Vita-Assay (AG6W, AN6W, AR6W) culture plates, is based on the preferential adhesion of invasive rare blood cells of tissue origin to a tissue or tumor microenvironment mimic-the so-called cell adhesion matrix (CAM), which has a demonstrated ability to enrich viable CTCs from blood up to one-million fold.The CAM-scaffold allows for the functional capture and identification of invasive CTCs (iCTCs) including invasive tumor progenitor (TP) cells from cancer-patients' blood. CAM-captured CTCs are capable of ingesting the CAM (CAM+) itself. Green and red fluorescent versions of Vita-Assay (AG6W and AR6W) allow for direct visualization of CAM-uptake by cancer cells. Vita-Assay CAM-enrichment has allowed for sensitive multiplex flow cytometric and microscopic detection of iCTCs from patients with cancers of the breast, ovary, prostate, pancreas, colorectum, and lung; it has also been successfully utilized for ex vivo drug-sensitivity testing of ovarian-cancer patient CTCs. The CAM enrichment method is equally suitable for the separation of iCTCs and TP cells in ascites and pleural fluid. PMID:26820949

  8. Delivering Better Quality of Care: Relentless Focus and Starting with the End in Mind at DaVita.

    PubMed

    Nissenson, Allen R

    2016-03-01

    The care of patients with end-stage renal disease has been evolving since the implementation of the Medicare entitlement for ESRD in 1973. Over the past 43 years, patients with ESRD have become increasingly complex with multiple comorbid conditions and the average age of new ESRD patients has continued to climb. Despite these challenges, progress has been made in improving mortality and morbidity, but the pace has generally been slow. The consolidation of the US dialysis industry has afforded large providers to achieve economies of scale and efficiencies. By reinvesting resources in innovative programs, the improvements in outcomes have accelerated. At DaVita, we have reimagined care for our ESRD patients by creating a Patient-Focused Quality Pyramid, an approach to holistic, patient-centered care that builds on the foundation of well-known dialysis metrics like adequacy and anemia management to drive more complex programs like fluid, medication, diabetes, and infection management. The ultimate goal is to improve survival, keep patients healthy and out of the hospital, enhance the patient experience of care, and thereby achieve optimal health-related quality of life. For two consecutive years, DaVita facilities, using this approach, have achieved superior performance in the CMS 5-Star rating program, most recently with 46% of facilities achieving 4 or 5 stars compared with only 23% of facilities outside of DaVita receiving 4 or 5 stars. This rating system has components of fundamentals, and more complex outcomes and our results are an external validation of the success of our approach in improving the lives of patients. PMID:26749498

  9. Who was the man who discovered the "Lewy bodies"?

    PubMed

    Rodrigues e Silva, Antonio M; Geldsetzer, Felix; Holdorff, Bernd; Kielhorn, Friedrich W; Balzer-Geldsetzer, Monika; Oertel, Wolfgang H; Hurtig, Howard; Dodel, Richard

    2010-09-15

    In 1912, Fritz Heinrich Lewy described neuronal inclusions in the brain of patients who had suffered from Paralysis agitans (i.e., Parkinson's disease). Later, these findings became the so-called "Lewy bodies." However, little is known about the man who made this discovery. Our aim was to investigate Lewy's private and professional life and to gather information for a detailed biography. We contacted over 100 archives, libraries, and museums in Germany, Poland, Switzerland, United Kingdom, and United States. Over 300 documents, publications, and photos were collected. Lewy was born in Berlin, Germany in 1885 and lived there until 1933. After his dismissal on racial grounds by the Nazis, Lewy emigrated to England in 1933 and to the United States of America in 1934, where he lived and worked until his death in 1950. This article gives a summary of Lewy's life and briefly presents his contribution to German and American neurology. PMID:20669275

  10. Phosphorus Lewis acids: emerging reactivity and applications in catalysis.

    PubMed

    Bayne, J M; Stephan, D W

    2016-02-21

    Part of the renaissance in main group chemistry has been a result of the focus on reactivity. This has led to the development of applications in stoichiometric reactivity and catalysis. In this tutorial review, we focus attention on the role of phosphorus-based Lewis acids in such advances. While early literature recognizes the role of P(iii) and P(v) electrophiles in coordination chemistry, it has generally been more recent studies that have focused on applications of this Lewis acidity. Applications of these novel P-based Lewis acids in stoichiometric reactivity, Lewis acid catalysis and frustrated Lewis pair (FLP) reactivity are reviewed. These advances demonstrate that P-based Lewis acids are a powerful tool for further developments in metal-free catalysis. PMID:26255595

  11. [Cognitive function and blood pressure regulation in Lewy body diseases].

    PubMed

    Asahina, Masato

    2013-01-01

    It is well known that autonomic failure is severer in patients with dementia with Lewy bodies (DLB) compared with patients with Parkinson's disease (PD). According to the Braak's hypothesis, Lewy bodies first appear in the olfactory bulb or peripheral autonomic nervous system. Lewy bodies in the peripheral autonomic nervous system ascend to dorsal motor nuclei of vagus nerve, while those in the olfactory bulb expand to the limbic system. Lewy bodies later attain the substantia nigra. However, it seems that Braak staging can not explain difference in severity of autonomic failure between DLB and PD. As a possibility, in DLB patients with significant autonomic failure, Lewy bodies may have been localized to the peripheral autonomic nervous system in a long time before onset of dementia or parkinsonism, and propagation of Lewy bodies into the central nervous system may be initiated by apparition of certain promotion factor, such as ageing and amyloid-β. PMID:24291999

  12. Clinicopathological Correlates of Lewy Body Disease: Fundamental Issues

    PubMed Central

    Ahn, Tae-Beom

    2010-01-01

    Lewy body pathology (LBP) is the pathological hallmark of Lewy body diseases, such as Parkinson’s disease and Lewy body dementia. Recent studies have shed new light on the role of LBP, the interactions of LBP with concomitant pathologies, and the propagation of LBP from the olfactory bulb and enteric nervous system to the central nervous system. The intrinsic difficulty with identifying clinicopathological correlates could be overcome by improving our understanding of the pathological evolution of LBP. PMID:24868372

  13. Lewis Acid Catalyzed Synthesis of Cyanidophosphates.

    PubMed

    Bläsing, Kevin; Ellinger, Stefan; Harloff, Jörg; Schulz, Axel; Sievert, Katharina; Täschler, Christoph; Villinger, Alexander; Zur Täschler, Cornelia

    2016-03-14

    Salts containing new cyanido(fluorido)phosphate anions of the general formula [PF6-n (CN)n ](-) (n=1-4) were synthesized by a very mild Lewis-acid-catalyzed synthetic protocol and fully characterized. All [PF6-n (CN)n ](-) (n=1-4) salts could be isolated on a preparative scale. It was also possible to detect the [PF(CN)5 ](-) but not the [P(CN)6 ](-) anion. The best results with respect to purity, yield, and low cost were obtained when the F(-) /CN(-) substitution reactions were carried out in ionic liquids. PMID:26849385

  14. Ablative Material Testing at Lewis Rocket Lab

    NASA Technical Reports Server (NTRS)

    1997-01-01

    The increasing demand for a low-cost, reliable way to launch commercial payloads to low- Earth orbit has led to the need for inexpensive, expendable propulsion systems for new launch vehicles. This, in turn, has renewed interest in less complex, uncooled rocket engines that have combustion chambers and exhaust nozzles fabricated from ablative materials. A number of aerospace propulsion system manufacturers have utilized NASA Lewis Research Center's test facilities with a high degree of success to evaluate candidate materials for application to new propulsion devices.

  15. NASA Lewis Research Center Futuring Workshop

    NASA Technical Reports Server (NTRS)

    Boroush, Mark; Stover, John; Thomas, Charles

    1987-01-01

    On October 21 and 22, 1986, the Futures Group ran a two-day Futuring Workshop on the premises of NASA Lewis Research Center. The workshop had four main goals: to acquaint participants with the general history of technology forecasting; to familiarize participants with the range of forecasting methodologies; to acquaint participants with the range of applicability, strengths, and limitations of each method; and to offer participants some hands-on experience by working through both judgmental and quantitative case studies. Among the topics addressed during this workshop were: information sources; judgmental techniques; quantitative techniques; merger of judgment with quantitative measurement; data collection methods; and dealing with uncertainty.

  16. Determination of critical habitat for the endangered Nelson's bighorn sheep in southern California

    USGS Publications Warehouse

    Turner, J.C.; Douglas, C.L.; Hallum, C.R.; Krausman, P.R.; Ramey, R.R.

    2004-01-01

    The United States Fish and Wildlife Service's (USFWS) designation of critical habitat for the endangered Nelson's bighorn sheep (Ovis canadensis nelsoni) in the Peninsular Ranges of southern California has been controversial because of an absence of a quantitative, repeatable scientific approach to the designation of critical habitat. We used 12,411 locations of Nelson's bighorn sheep collected from 1984-1998 to evaluate habitat use within 398 km2 of the USFWS-designated critical habitat in the northern Santa Rosa Mountains, Riverside County, California. We developed a multiple logistic regression model to evaluate and predict the probability of bighorn use versus non-use of native landscapes. Habitat predictor variables included elevation, slope, ruggedness, slope aspect, proximity to water, and distance from minimum expanses of escape habitat. We used Earth Resources Data Analysis System Geographic Information System (ERDAS-GIS) software to view, retrieve, and format predictor values for input to the Statistical Analysis Systems (SAS) software. To adequately account for habitat landscape diversity, we carried out an unsupervised classification at the outset of data inquiry using a maximum-likelihood clustering scheme implemented in ERDAS. We used the strata resulting from the unsupervised classification in a stratified random sampling scheme to minimize data loads required for model development. Based on 5 predictor variables, the habitat model correctly classified >96% of observed bighorn sheep locations. Proximity to perennial water was the best predictor variable. Ninety-seven percent of the observations were within 3 km of perennial water. Exercising the model over the northern Santa Rosa Mountain study area provided probabilities of bighorn use at a 30 x 30-m2 pixel level. Within the 398 km 2 of USFWS-designated critical habitat, only 34% had a graded probability of bighorn use to non-use ranging from ???1:1 to 6,044:1. The remaining 66% of the study area had odds of having bighorn use <1:1 or it was more likely not to be used by bighorn sheep. The USFWS designation of critical habitat included areas (45 km2) of importance (2.5 to ???40 observations per km2 per year) to Nelson's bighorn sheep and large landscapes (353 km2) that do not appear to be used (<1 observation per km2 per year).

  17. A zwitterionic carbanion frustrated by boranes--dihydrogen cleavage with weak Lewis acids via an "inverse" frustrated Lewis pair approach.

    PubMed

    Li, Hui; Aquino, Adelia J A; Cordes, David B; Hung-Low, Fernando; Hase, William L; Krempner, Clemens

    2013-10-30

    The synthesis, structural characterization, and acid-base chemistry of [C(SiMe2OCH2CH2OMe)3]Na (2), a sterically encumbered zwitterionic organosodium compound, is reported. 2 is a strong Brønsted base that forms frustrated Lewis pairs (FLPs) with a number of boron-containing Lewis acids ranging from weakly Lewis acidic aryl and alkyl boranes to various alkyl borates. These intermolecular FLPs readily cleave H2, which confirms that even poor Lewis acids can engage in FLP-mediated H2 cleavage provided that the present bulky base is of sufficiently high Brønsted basicity. PMID:24124979

  18. Lewy Body Pathology in Familial Alzheimer Disease

    PubMed Central

    Leverenz, James B.; Fishel, Mark A.; Peskind, Elaine R.; Montine, Thomas J.; Nochlin, David; Steinbart, Ellen; Raskind, Murray A.; Schellenberg, Gerard D.; Bird, Thomas D.; Tsuang, Debby

    2006-01-01

    Background The origin and significance of Lewy bodies and neurites (Lewy body pathology [LBP]) in Alzheimer disease (AD) are poorly understood. Objective To examine LBP in the brainstem, limbic cortex, and neocortex of a large number of familial AD cases with mutations in 2 presenilin (PSEN) genes. Methods Twenty-five familial AD cases with 9 known PSEN 1 mutations and 14 familial AD cases with a single PSEN 2 mutation (N141I) were examined for LBP using α-synuclein immunohistochemistry and sampling of multiple brainstem and cortical regions. Results The amygdala was the most vulnerable site for LBP. In fact, virtually all (24 [96%] of 25 cases) of the PSEN 1 mutation cases had LBP in the amygdala. The PSEN 1 mutation cases also had more frequent LBP in the amygdala and neocortex than those with the PSEN 2 mutation. However, within families with a single mutation of either PSEN 1 or PSEN 2, there was frequent variability of the LBP. Conclusion These findings suggest that there are genetic influences on the presence of LBP in familial AD as demonstrated by the differences between PSEN 1 and PSEN 2 mutation cases. PMID:16533963

  19. Neurophysiological biomarkers for Lewy body dementias

    PubMed Central

    Cromarty, Ruth A.; Elder, Greg J.; Graziadio, Sara; Baker, Mark; Bonanni, Laura; Onofrj, Marco; O’Brien, John T.; Taylor, John-Paul

    2016-01-01

    Objective Lewy body dementias (LBD) include both dementia with Lewy bodies (DLB) and Parkinson’s disease with dementia (PDD), and the differentiation of LBD from other neurodegenerative dementias can be difficult. Currently, there are few biomarkers which might assist early diagnosis, map onto LBD symptom severity, and provide metrics of treatment response. Traditionally, biomarkers in LBD have focussed on neuroimaging modalities; however, as biomarkers need to be simple, inexpensive and non-invasive, neurophysiological approaches might also be useful as LBD biomarkers. Methods In this review, we searched PubMED and PsycINFO databases in a semi-systematic manner in order to identify potential neurophysiological biomarkers in the LBDs. Results We identified 1491 studies; of these, 37 studies specifically examined neurophysiological biomarkers in LBD patients. We found that there was substantial heterogeneity with respect to methodologies and patient cohorts. Conclusion Generally, many of the findings have yet to be replicated, although preliminary findings reinforce the potential utility of approaches such as quantitative electroencephalography and motor cortical stimulation paradigms. Significance Various neurophysiological techniques have the potential to be useful biomarkers in the LBDs. We recommend that future studies focus on maximising the diagnostic specificity and sensitivity of the most promising neurophysiological biomarkers. PMID:26183755

  20. Commentary: The Development of Hippocampal-Dependent Memory Functions: Theoretical Comments on Jabs and Nelson Review (2015)

    ERIC Educational Resources Information Center

    Bachevalier, Jocelyne

    2015-01-01

    Studies investigating the development of memory processes and their neural substrates have flourished over the past two decades. The review by Jabs and Nelson (2015) adds an important piece to our understanding of the maturation of different elements and circuits within the hippocampal system and their association with the progressive development

  1. A Program Evaluation and Student Follow-Up of Developmental Studies Students at Thomas Nelson Community College, 1975-1977.

    ERIC Educational Resources Information Center

    Braxton, Pearl C.; And Others

    This evaluation of the Developmental Studies Program at Thomas Nelson Community College (TNCC) draws from five in-depth studies of the characteristics, academic achievement, and persistence of developmental students and from other TNCC reports. After introductory material on the history and purpose of the program evaluation, a four-part summary of…

  2. Commentary: The Development of Hippocampal-Dependent Memory Functions: Theoretical Comments on Jabès and Nelson Review (2015)

    ERIC Educational Resources Information Center

    Bachevalier, Jocelyne

    2015-01-01

    Studies investigating the development of memory processes and their neural substrates have flourished over the past two decades. The review by Jabès and Nelson (2015) adds an important piece to our understanding of the maturation of different elements and circuits within the hippocampal system and their association with the progressive development…

  3. 78 FR 66353 - EAM Nelson Holdings, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-05

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission EAM Nelson Holdings, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for Blanket Section 204 Authorization This is a supplemental notice in the above-referenced proceeding, of EAM...

  4. The Nelson-Denny Reading Test as a Predictor of Academic Success in Selected Classes in a Specific Community College.

    ERIC Educational Resources Information Center

    Gudan, Sirkka

    A review of the literature indicates that the Nelson-Denny Reading Test (NDRT) may be a viable instrument for screening students and predicting their academic success in particular circumstances. In 1981, a study was conducted at Schoolcraft College to determine the extent of the relationship between the reading abilities of entering students and…

  5. The "Naked Truth" Isn't Very Revealing: A Response to Wade Nelson on School Reform in Minnesota.

    ERIC Educational Resources Information Center

    Pitton, Debra Eckerman

    1999-01-01

    A participant in Minnesota's standards-based reform initiative claims Wade Nelson, in his May 1998 "Kappan" article, is misinformed about teachers' exclusion from this movement. The standards constitute a minimal competence level in reading, math, and writing, were developed cooperatively, and have raised teacher expectations of students.…

  6. Comments on Mika's Critique of Hartnett, Nelson, and Rinn's Article, "Gifted or ADHD? The Possibilities of Misdiagnosis"

    ERIC Educational Resources Information Center

    Goerss, Jean; Amend, Edward R.; Webb, James T.; Webb, Nadia; Beljan, Paul

    2006-01-01

    The Hartnett, Nelson, and Rinn 2004 study indicates that diagnostic confusion between ADD/ADHD and giftedness exists, and that research on medication practices is warranted. Mika disagrees, saying that there is no empirical evidence of misdiagnosis of gifted children as having ADD/ADHD. We disagree with Mika's logic, and describe evidence that…

  7. [A life among insects and books: an interview with Nelson Papavero].

    PubMed

    Klassa, Bruna; Santos, Charles Morphy D

    2012-12-01

    Nelson Papavero is one of the top representatives of Brazilian zoology. His decisive contributions to this science began in the second half of the twentieth century, when he started publishing in the areas of zoology, systematics, biogeography, and the history of science while also working at graduate courses and training teachers and students. He was key to the introduction of Hennig's phylogenetic systematics in Brazil and its chief advocate. His active participation in the creation of the Special Courses on Zoological Systematics within the National Council for Scientific and Technological Development and his work at numerous administrative posts which he held during his academic career were vital to the development of zoology and comparative biology in Brazil. His endeavors also reached into other Latin American countries, like Mexico and Argentina. PMID:23295660

  8. Revisiting the Nelson-Morfey scaling law for flow noise from duct constrictions

    NASA Astrophysics Data System (ADS)

    Kårekull, Oscar; Efraimsson, Gunilla; Åbom, Mats

    2015-11-01

    The semi-empirical scaling law by Nelson and Morfey [1] predicts the noise generation from constrictions in ducts with low Mach number flows. The results presented here demonstrate that the original model loses accuracy for constrictions of high pressure loss. A generalization based on a momentum flux assumption of the dipole forces is suggested and is evaluated against measurement results for orifice geometries of higher pressure loss than earlier evaluated. A prediction model including constrictions at flow duct terminations is also suggested. Improved accuracy for the predictions of the new model is found for orifice geometries of high pressure loss inside and at the end of ducts. The extended model is finally evaluated by measurements on a regular ventilation air terminal device.

  9. Application of an improved Nelson-Nguyen analysis to eccentric, arbitrary profile liquid annular seals

    NASA Technical Reports Server (NTRS)

    Padavala, Satyasrinivas; Palazzolo, Alan B.; Vallely, Pat; Ryan, Steve

    1994-01-01

    An improved dynamic analysis for liquid annular seals with arbitrary profile based on a method, first proposed by Nelson and Nguyen, is presented. An improved first order solution that incorporates a continuous interpolation of perturbed quantities in the circumferential direction, is presented. The original method uses an approximation scheme for circumferential gradients, based on Fast Fourier Transforms (FFT). A simpler scheme based on cubic splines is found to be computationally more efficient with better convergence at higher eccentricities. A new approach of computing dynamic coefficients based on external specified load is introduced. This improved analysis is extended to account for arbitrarily varying seal profile in both axial and circumferential directions. An example case of an elliptical seal with varying degrees of axial curvature is analyzed. A case study based on actual operating clearances of an interstage seal of the Space Shuttle Main Engine High Pressure Oxygen Turbopump is presented.

  10. Interview with Smithsonian NASM Spacesuit Curator Dr. Cathleen Lewis

    NASA Technical Reports Server (NTRS)

    Lewis, Cathleen; Wright, Rebecca

    2012-01-01

    Dr. Cathleen Lewis was interviewed by Rebecca Wright during the presentation of an "Interview with Smithsonian NASM Spacesuit Curator Dr. Cathleen Lewis" on May 14, 2012. Topics included the care, size, and history of the spacesuit collection at the Smithsonian and the recent move to the state-of-the-art permanent storage facility at the Udvar-Hazy facility in Virginia.

  11. Thoughts on Teaching: John L. Lewis, Jesus, and President Bush.

    ERIC Educational Resources Information Center

    Starnes, Bobby Ann

    2004-01-01

    Bobby Ann Starnes, the author of this article, grew up with portraits of two important people displayed prominently in her home, Jesus, and John L. Lewis. Lewis, a giant among American leaders in the first half of the twentieth century, sent hundreds of organizers to help create some of the nation's leading labor unions, including the United…

  12. 32 CFR 552.168 - Fort Lewis Area Access Office.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 32 National Defense 3 2012-07-01 2009-07-01 true Fort Lewis Area Access Office. 552.168 Section 552.168 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY MILITARY RESERVATIONS AND NATIONAL CEMETERIES REGULATIONS AFFECTING MILITARY RESERVATIONS Land Use Policy for Fort Lewis, Yakima Training Center, and Camp Bonneville...

  13. Impairments of Speech Fluency in Lewy Body Spectrum Disorder

    ERIC Educational Resources Information Center

    Ash, Sharon; McMillan, Corey; Gross, Rachel G.; Cook, Philip; Gunawardena, Delani; Morgan, Brianna; Boller, Ashley; Siderowf, Andrew; Grossman, Murray

    2012-01-01

    Few studies have examined connected speech in demented and non-demented patients with Parkinson's disease (PD). We assessed the speech production of 35 patients with Lewy body spectrum disorder (LBSD), including non-demented PD patients, patients with PD dementia (PDD), and patients with dementia with Lewy bodies (DLB), in a semi-structured

  14. Impairments of Speech Fluency in Lewy Body Spectrum Disorder

    ERIC Educational Resources Information Center

    Ash, Sharon; McMillan, Corey; Gross, Rachel G.; Cook, Philip; Gunawardena, Delani; Morgan, Brianna; Boller, Ashley; Siderowf, Andrew; Grossman, Murray

    2012-01-01

    Few studies have examined connected speech in demented and non-demented patients with Parkinson's disease (PD). We assessed the speech production of 35 patients with Lewy body spectrum disorder (LBSD), including non-demented PD patients, patients with PD dementia (PDD), and patients with dementia with Lewy bodies (DLB), in a semi-structured…

  15. Difficulty Processing Temporary Syntactic Ambiguities in Lewy Body Spectrum Disorder

    ERIC Educational Resources Information Center

    Grossman, Murray; Gross, Rachel G.; Moore, Peachie; Dreyfuss, Michael; McMillan, Corey T.; Cook, Philip A.; Ash, Sherry; Siderowf, Andrew

    2012-01-01

    While grammatical aspects of language are preserved, executive deficits are prominent in Lewy body spectrum disorder (LBSD), including Parkinson's disease (PD), Parkinson's dementia (PDD) and dementia with Lewy bodies (DLB). We examined executive control during sentence processing in LBSD by assessing temporary structural ambiguities. Using an…

  16. The Organization of Narrative Discourse in Lewy Body Spectrum Disorder

    ERIC Educational Resources Information Center

    Ash, Sharon; McMillan, Corey; Gross, Rachel G.; Cook, Philip; Morgan, Brianna; Boller, Ashley; Dreyfuss, Michael; Siderowf, Andrew; Grossman, Murray

    2011-01-01

    Narrative discourse is an essential component of day-to-day communication, but little is known about narrative in Lewy body spectrum disorder (LBSD), including Parkinson's disease (PD), Parkinson's disease with dementia (PDD), and dementia with Lewy bodies (DLB). We performed a detailed analysis of a semi-structured speech sample in 32 non-aphasic…

  17. Retinoid-related orphan receptor gamma t (RORγt) inhibitors from Vitae Pharmaceuticals (WO2015116904) and structure proposal for their Phase I candidate VTP-43742.

    PubMed

    Gege, Christian

    2016-06-01

    Retinoic acid receptor-related orphan nuclear receptor gamma t (RORγt or RORC2) is a key transcription factor for the differentiation of naïve proinflammatory CD4(+) T cells and the production of T helper-17 (TH17) cells. Inhibiting RORγt activity is thought to be beneficial in targeting a variety of inflammatory and autoimmune disorders, however current candidates remain to be validated in the clinic. Recently Vitae Pharmaceuticals successfully finished its Phase 1 single ascending dose clinical study with their proprietary RORγt inverse agonist VTP-43742. On the basis of the reported promising results, Vitae Pharmaceuticals could currently be considered as having the leading clinical candidate in the RORγt inverse agonist category. This prompts the interest on the exact chemical structure of their clinical candidate. The first relevant patent application (WO2014179564) from Vitae Pharmaceuticals describes RORγt inverse agonists with a 5,6-dihydro-4H-pyrrolo[3,4-d]thiazole core, while in the second and latest patent application (WO2015116904) this element has changed towards a 6,7-dihydro-5H-pyrrolo[3,4-b]pyridine core. By combining information from Vitae's patent applications and trustworthy online information, the potential elucidation of the chemical structure of clinical candidate VTP-43742 is described. PMID:26895086

  18. NASA Lewis Meshed VSAT Workshop meeting summary

    NASA Technical Reports Server (NTRS)

    Ivancic, William

    1993-01-01

    NASA Lewis Research Center's Space Electronics Division (SED) hosted a workshop to address specific topics related to future meshed very small-aperture terminal (VSAT) satellite communications networks. The ideas generated by this workshop will help to identify potential markets and focus technology development within the commercial satellite communications industry and NASA. The workshop resulted in recommendations concerning these principal points of interest: the window of opportunity for a meshed VSAT system; system availability; ground terminal antenna sizes; recommended multifrequency for time division multiple access (TDMA) uplink; a packet switch design concept for narrowband; and fault tolerance design concepts. This report presents a summary of group presentations and discussion associated with the technological, economic, and operational issues of meshed VSAT architectures that utilize processing satellites.

  19. [Clinical Neuropsychology of Dementia with Lewy Bodies].

    PubMed

    Nagahama, Yasuhiro

    2016-02-01

    Dementia with Lewy bodies (DLB) shows lesser memory impairment and more severe visuospatial disability than Alzheimer disease (AD). Although deficits in both consolidation and retrieval underlie the memory impairment, retrieval deficit is predominant in DLB. Visuospatial dysfunctions in DLB are related to the impairments in both ventral and dorsal streams of higher visual information processing, and lower visual processing in V1/V2 may also be impaired. Attention and executive functions are more widely disturbed in DLB than in AD. Imitation of finger gestures is impaired more frequently in DLB than in other mild dementia, and provides additional information for diagnosis of mild dementia, especially for DLB. Pareidolia, which lies between hallucination and visual misperception, is found frequently in DLB, but its mechanism is still under investigation. PMID:26873237

  20. Superconducting Microwave Electronics at Lewis Research Center

    NASA Technical Reports Server (NTRS)

    Warner, Joseph D.; Bhasin, Kul B.; Leonard, Regis F.

    1991-01-01

    Over the last three years, NASA Lewis Research Center has investigated the application of newly discovered high temperature superconductors to microwave electronics. Using thin films of YBa2Cu3O7-delta and Tl2Ca2Ba2Cu3Ox deposited on a variety of substrates, including strontium titanate, lanthanum gallate, lanthanum aluminate and magnesium oxide, a number of microwave circuits have been fabricated and evaluated. These include a cavity resonator at 60 GHz, microstrip resonators at 35 GHz, a superconducting antenna array at 35 GHz, a dielectric resonator at 9 GHz, and a microstrip filter at 5 GHz. Performance of some of these circuits as well as suggestions for other applications are reported.

  1. [Autonomic disorders in dementia with Lewy bodies].

    PubMed

    Preobrazhenskaia, I S; Strutsenko, A A

    2005-01-01

    Fifty patients diagnosed with dementia with Lewy bodies (DLB) according to criteria of I. MacKleith et al (2000), mean age 71.1 +/- 6.1 years, have been studied. Severity of dimentia was evaluated using a battery of neuropsychological scales and tests. A state of autonomic nervous system function was determined during clinical examination, the results of which were used as a basis for the Scale of autonomic disorders severity, and by instrumental methods. Most of patients with DLB had autonomic disorders, such as orthostatic hypotension, heat intolerability, dryness of cutaneous epithelium and mouth mucous membranes, urination disorders. The study of reactivity of autonomic nervous system revealed a predominance of parasympathetic reactions. The authors believe that autonomic disorders are typical for DLB and are the result of affection of the peripheral nerves, stem and spinal autonomic structures. PMID:15792138

  2. Reactivity of Lewis basic platinum complexes towards fluoroboranes.

    PubMed

    Bauer, Jürgen; Braunschweig, Holger; Dewhurst, Rian D; Radacki, Krzysztof

    2013-07-01

    We herein report detailed investigations into the interaction of Lewis acidic fluoroboranes, for example BF2Pf (Pf=perfluorophenyl) and BF2Ar(F) (Ar(F)=3,5-bis(trifluoromethyl)phenyl), with Lewis basic platinum complexes such as [Pt(PEt3)3] and [Pt(PCy3)2] (Cy=cyclohexyl). Two presumed Lewis adducts could be identified in solution and corresponding secondary products of these Lewis adducts were characterized in the solid state. Furthermore, the concept of frustrated Lewis pairs (FLP) was applied to the activation of ethene in the system [Pt(BPf3)(CH2CH2)(dcpp)] (dcpp=1,3-bis(dicyclohexylphosphino)propane; Pf=perfluorophenyl). Finally, DFT calculations were performed to determine the interaction between the platinum-centered Lewis bases and the boron-centered Lewis acids. Additionally, several possible mechanisms for the oxidative addition of the boranes BF3, BCl3, and BF2Ar(F) to the model complex [Pt(PMe3)2] are presented. PMID:23677702

  3. Tunable luminescence of bithiophene-based flexible Lewis pairs.

    PubMed

    Cao, Yang; Nagle, Jeffrey K; Wolf, Michael O; Patrick, Brian O

    2015-04-22

    Bithiophene-based flexible Lewis pairs with P(O)R2 (R = phenyl, isopropyl) and BMes2 (Mes = 2,4,6-trimethylphenyl) functionalities are able to toggle between closed, Lewis adduct and open, unbound Lewis pair structures. The open structure is favored in strong hydrogen bond donating solvents or at higher temperatures giving rise to an intense charge-transfer (CT) luminescence, while the closed structure without this emission dominates in non-hydrogen bond donating solvents or at lower temperatures. Intermediate solvents result in an equilibrium mixture of both structures, which shows unusual mixed emission that is dependent on excitation wavelength. PMID:25860619

  4. Do the length-based (Broselow) Tape, APLS, Argall and Nelson's formulae accurately estimate weight of Indian children?

    PubMed

    Varghese, A; Vasudevan, V K; Lewin, S; Indumathi, C K; Dinakar, C; Rao, S D Subha

    2006-10-01

    This study was aimed at validating the usefulness of a length based pediatric emergency tape (Broselow) in an Indian population. The secondary objective was to validate age based weight estimation formulae (Nelson, Argalls, APLS) for emergency needs (doses, sizes). This cross sectional study was done at a tertiary teaching hospital on a sample of 500 children attending outpatient clinic. Inclusion criteria was age between 1 month to 12 years. Children who were unstable, uncooperative or critically ill requiring emergency care and those measuring more than 145 cm in length or weighing more than 35 kg weight were excluded from the study. Measurement of actual weights, calculation of weight, adrenaline dose, fluid bolus and endotracheal tube size was done by all four methods. Results indicated good positive correlation between actual measured weights and weights estimated using Broselow Tape (r = 0.974), APLS (r = 0.902), Argalls modification (r = 0.902), and combined Nelson formulae (0.935). However, specific Nelson formulas for 7-12 yr and 3-12 mo were especially poor in correlation. Bland-Altman Plots comparing actual weight showed least mean bias for Broselow Tape estimations in < 15 kg group (0.080 +/- 0.96 kg) and maximum bias with Nelsons formula for 7 to12 yr (5.204 +/- 4.272 kg). For adrenaline doses and fluid bolus calculations, Broselow estimations were valid estimates. Broselow tape did underestimate endotracheal tube size (mean bias -0.53 +/- 0.18). To conclude, length based pediatric emergency tape (Broselow) correlates well with overall emergency decision making process in our setting. This is especially validated in the age group 0.1 to 6.7 yr weighing less than 15 kg. PMID:17079832

  5. 75 FR 11151 - Lewis County Development Corporation; Notice of Preliminary Permit Application Accepted for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-10

    ... Federal Energy Regulatory Commission Lewis County Development Corporation; Notice of Preliminary Permit... March 3, 2010. On November 16, 2009, Lewis County Development Corporation (Lewis County Corp) filed an... Croghan Dam, on the on the Beaver River, in Lewis County, New York. The proposed project would consist...

  6. Lewis Acid-Base, Molecular Modeling, and Isotopic Labeling in a Sophomore Inorganic Chemistry Laboratory

    ERIC Educational Resources Information Center

    Nataro, Chip; Ferguson, Michelle A.; Bocage, Katherine M.; Hess, Brian J.; Ross, Vincent J.; Swarr, Daniel T.

    2004-01-01

    An experiment to prepare a deuterium labeled adduct of a Lewis acid and Lewis base, to use computational methods allowing students to visualize the LUMO of Lewis acids, the HOMO of Lewis bases and the molecular orbitals of the adduct that is formed is developed. This allows students to see the interplay between calculated and experimental results.

  7. An observational study of ice effects on Nelson River estuarine variability, Hudson Bay, Canada

    NASA Astrophysics Data System (ADS)

    Wang, Ruixue; McCullough, Greg K.; Gunn, Geoffrey G.; Hochheim, Klaus P.; Dorostkar, Abbas; Sydor, Kevin; Barber, David G.

    2012-09-01

    Many estuaries in high latitude regions are subjected to seasonally ice-covered conditions. However, ice effects on estuarine variability have received limited scientific attention and remain poorly understood. In this paper, an 11-month mooring record is used to examine seasonal variation of estuarine hydrodynamics in the Nelson River estuary (NRE), Hudson Bay (HB), in northern Canada. We show that ice cover strongly affects tidal amplitudes, velocities and phases in the NRE. In the mid-winter, the M2 tidal amplitude and consequently the tidal range are significantly reduced due to under-ice friction in HB, while conversely the M2 tidal velocity is amplified due to reduction of cross-section of the channel by formation of fast ice. A stronger surface seaward residual flow observed in the winter indicates that the formation of fast ice could also enhance the residual circulation. Suspended sediment concentration in the river mouth is reduced, also possibly due to the formation of fast ice that protects shallow nearshore shoals from erosion. This study demonstrates the importance of ice effects on estuarine variability and the complexity of processes in a seasonally ice-covered estuary.

  8. Clinical Features of Alzheimer Disease With and Without Lewy Bodies

    PubMed Central

    Chung, Eun Joo; Babulal, Ganesh M.; Monsell, Sarah E.; Cairns, Nigel J.; Roe, Catherine M.; Morris, John C.

    2015-01-01

    IMPORTANCE Lewy bodies are a frequent coexisting pathology in late-onset Alzheimer disease (AD). Previous studies have examined the contribution of Lewy bodies to the clinical phenotype of late-onset AD with variable findings. OBJECTIVE To determine whether the presence of Lewy body pathology influences the clinical phenotype and progression of symptoms in longitudinally assessed participants with AD. DESIGN, SETTING, AND PARTICIPANTS Retrospective clinical and pathological cohort study of 531 deceased participants who met the neuropathologic criteria for intermediate or high likelihood of AD according to the National Institute on Aging–Ronald Reagan Institute guidelines for the neuropathologic diagnosis of AD. All participants had a clinical assessment within 2 years of death. The data were obtained from 34 AD centers maintained by the National Alzheimer Coordinating Center and spanned from September 12, 2005, to April 30, 2013. EXPOSURES Standardized neuropathologic assessment and then brain autopsy after death. MAIN OUTCOMES AND MEASURES Clinical and neuropsychiatric test scores. RESULTS The mean (SD) age at death was statistically significantly younger for participants who had AD with Lewy bodies (77.9 [9.5] years) than for participants who had AD without Lewy bodies (80.2 [11.1] years) (P = .01). The mean (SD) age at onset of dementia symptoms was also younger for participants who had AD with Lewy bodies (70.0 [9.9] years) than for participants who had AD without Lewy bodies (72.2 [12.3] years) (P = .03). More men than women had AD with Lewy bodies (P = .01). The frequency of having at least 1 APOE ε4 allele was higher for participants who had AD with Lewy bodies than for participants who had AD without Lewy bodies (P = .03). After adjusting for age, sex, education, frequency of plaques (neuritic and diffuse), and tangle stage, we found that participants who had AD with Lewy bodies had a statistically significantly higher mean (SD) Neuropsychiatric Inventory Questionnaire score (6.59 [1.44] [95% CI, 3.75–9.42] vs 5.49 [1.39] [95% CI, 2.76–8.23]; P = .04) and a statistically significantly higher mean (SD) Unified Parkinson Disease Rating Scale motor score (0.81 [0.18] [95% CI, 0.45–1.17] vs 0.54 [0.18] [95% CI, 0.19–0.88]; P < .001) than did participants who had AD without Lewy bodies. CONCLUSIONS AND RELEVANCE Participants with both AD and Lewy body pathology have a clinical phenotype that may be distinguished from AD alone. The frequency of Lewy bodies in AD and the association of Lewy bodies with the APOE ε4 allele suggest potential common mechanisms for AD and Lewy body pathologies. PMID:25985321

  9. Distance Learning With NASA Lewis Research Center's Learning Technologies Project

    NASA Technical Reports Server (NTRS)

    Petersen, Ruth

    1998-01-01

    The NASA Lewis Research Center's Learning Technologies Project (LTP) has responded to requests from local school district technology coordinators to provide content for videoconferencing workshops. Over the past year we have offered three teacher professional development workshops that showcase NASA Lewis-developed educational products and NASA educational Internet sites. In order to determine the direction of our involvement with distance learning, the LTP staff conducted a survey of 500 U.S. schools. We received responses from 72 schools that either currently use distance learning or will be using distance learning in 98-99 school year. The results of the survey are summarized in the article. In addition, the article provides information on distance learners, distance learning technologies, and the NASA Lewis LTP videoconferencing workshops. The LTP staff will continue to offer teacher development workshops through videoconferencing during the 98-99 school year. We hope to add workshops on new educational products as they are developed at NASA Lewis.

  10. FEATURE B. MACHINE GUN POSITION WITH LEWIS MOUNT, VIEW FACING ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    FEATURE B. MACHINE GUN POSITION WITH LEWIS MOUNT, VIEW FACING NORTHWEST. - Naval Air Station Barbers Point, Battery-Machine Gun Positions, South of Point Cruz Road & west of Coral Sea Road, Ewa, Honolulu County, HI

  11. FEATURE B. MACHINE GUN POSITION WITH LEWIS MOUNT, VIEW FACING ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    FEATURE B. MACHINE GUN POSITION WITH LEWIS MOUNT, VIEW FACING NORTHWEST (with scale stick). - Naval Air Station Barbers Point, Battery-Machine Gun Positions, South of Point Cruz Road & west of Coral Sea Road, Ewa, Honolulu County, HI

  12. 123I-Metaiodobenzylguanidine Myocardial Scintigraphy in Lewy Body-Related Disorders: A Literature Review

    PubMed Central

    Chung, Eun Joo; Kim, Sang Jin

    2015-01-01

    Lewy body-related disorders are characterized by the presence of Lewy bodies and Lewy neurites, which have abnormal aggregations of α-synuclein in the nigral and extranigral areas, including in the heart. 123I-metaiodobenzylguanidine (MIBG) scintigraphy is a well-known tool to evaluate cardiac sympathetic denervation in the Lewy body-related disorders. MIBG scintigraphy showed low uptake of MIBG in the Lewy body-related disorders, including Parkinson’s disease, dementia with Lewy bodies, pure autonomic failure and rapid eye movement sleep behavior disorder. This review summarizes previous results on the diagnostic applications of MIBG scintigraphy in Lewy body-related disorders. PMID:26090077

  13. NASA Lewis Stirling engine computer code evaluation

    SciTech Connect

    Sullivan, T.J.

    1989-01-01

    In support of the US Department of Energy's Stirling Engine Highway Vehicle Systems program, the NASA Lewis Stirling engine performance code was evaluated by comparing code predictions without engine-specific calibration factors to GPU-3, P-40, and RE-1000 Stirling engine test data. The error in predicting power output was /minus/11 percent for the P-40 and 12 percent for the RE-1000 at design conditions and 16 percent for the GPU-3 at near-design conditions (2000 rpm engine speed versus 3000 rpm at design). The efficiency and heat input predictions showed better agreement with engine test data than did the power predictions. Concerning all data points, the error in predicting the GPU-3 brake power was significantly larger than for the other engines and was mainly a result of inaccuracy in predicting the pressure phase angle. Analysis into this pressure phase angle prediction error suggested that improvement to the cylinder hysteresis loss model could have a significant effect on overall Stirling engine performance predictions. 13 refs., 26 figs., 3 tabs.

  14. False memories in Lewy-body disease.

    PubMed

    Algarabel, Salvador; Pitarque, Alfonso; Sales, Alicia; Meléndez, Juan Carlos; Escudero, Joaquín

    2015-12-01

    Recently, de Boysson, Belleville, Phillips et al. (2011) found that patients with Lewy-body disease (LBD) showed significantly lower rates of false memories than healthy controls, using the Deese-Roediger-McDermott (DRM) experimental procedure. Given that this result could be explained by the practically null rate of true recognition in the LBD group (0.09), we decided to replicate the study by de Boysson et al. (2011), but including a new condition that would maximize the true recognition rate (and analyze its effect on the rate of false memories). Specifically, in a DRM experiment, we manipulated (within subjects) two study and recognition conditions: in the "immediate" condition, both the LBD patients and the control group of healthy older people received a different recognition test after each study list (containing twelve words associated with a non-presented critical word), while in the "delayed" condition (similar to the one in de Boysson et al., 2011), the participants received the entire series of study lists and then took only one recognition test. The results showed that, in both samples, the "immediate" condition produced higher corrected rates of both true and false recognition than the "delayed" condition, although they were both lower in the LBD patients, which shows that these patients are capable of encoding and recognizing the general similitude underlying information (gist memory) in the right conditions. PMID:26355527

  15. Lewis Research Center R and D Facilities

    NASA Technical Reports Server (NTRS)

    1991-01-01

    The NASA Lewis Research Center (LeRC) defines and develops advanced technology for high priority national needs. The work of the Center is directed toward new propulsion, power, and communications technologies for application to aeronautics and space, so that U.S. leadership in these areas is ensured. The end product is knowledge, usually in a report, that is made fully available to potential users--the aircraft engine industry, the energy industry, the automotive industry, the space industry, and other NASA centers. In addition to offices and laboratories for almost every kind of physical research in such fields as fluid mechanics, physics, materials, fuels, combustion, thermodynamics, lubrication, heat transfer, and electronics, LeRC has a variety of engineering test cells for experiments with components such as compressors, pumps, conductors, turbines, nozzles, and controls. A number of large facilities can simulate the operating environment for a complete system: altitude chambers for aircraft engines; large supersonic wind tunnels for advanced airframes and propulsion systems; space simulation chambers for electric rockets or spacecraft; and a 420-foot-deep zero-gravity facility for microgravity experiments. Some problems are amenable to detection and solution only in the complete system and at essentially full scale. By combining basic research in pertinent disciplines and generic technologies with applied research on components and complete systems, LeRC has become one of the most productive centers in its field in the world. This brochure describes a number of the facilities that provide LeRC with its exceptional capabilities.

  16. Exome sequencing in dementia with Lewy bodies.

    PubMed

    Keogh, M J; Kurzawa-Akanbi, M; Griffin, H; Douroudis, K; Ayers, K L; Hussein, R I; Hudson, G; Pyle, A; Cordell, H J; Attems, J; McKeith, I G; O'Brien, J T; Burn, D J; Morris, C M; Thomas, A J; Chinnery, P F

    2016-01-01

    Dementia with Lewy bodies (DLB) is the second most common form of degenerative dementia. Siblings of affected individuals are at greater risk of developing DLB, but little is known about the underlying genetic basis of the disease. We set out to determine whether mutations in known highly penetrant neurodegenerative disease genes are found in patients with DLB. Whole-exome sequencing was performed on 91 neuropathologically confirmed cases of DLB, supplemented by independent APOE genotyping. Genetic variants were classified using established criteria, and additional neuropathological examination was performed for putative mutation carriers. Likely pathogenic variants previously described as causing monogenic forms of neurodegenerative disease were found in 4.4% of patients with DLB. The APOE ɛ4 allele increased the risk of disease (P=0.0001), conferred a shorter disease duration (P=0.043) and earlier age of death (P=0.0015). In conclusion, although known pathogenic mutations in neurodegenerative disease genes are uncommon in DLB, known genetic risk factors are present in >60% of cases. APOE ɛ4 not only modifies disease risk, but also modulates the rate of disease progression. The reduced penetrance of reported pathogenic alleles explains the lack of a family history in most patients, and the presence of variants previously described as causing frontotemporal dementia suggests a mechanistic overlap between DLB and other neurodegenerative diseases. PMID:26836416

  17. NASA Lewis Stirling engine computer code evaluation

    NASA Technical Reports Server (NTRS)

    Sullivan, Timothy J.

    1989-01-01

    In support of the U.S. Department of Energy's Stirling Engine Highway Vehicle Systems program, the NASA Lewis Stirling engine performance code was evaluated by comparing code predictions without engine-specific calibration factors to GPU-3, P-40, and RE-1000 Stirling engine test data. The error in predicting power output was -11 percent for the P-40 and 12 percent for the Re-1000 at design conditions and 16 percent for the GPU-3 at near-design conditions (2000 rpm engine speed versus 3000 rpm at design). The efficiency and heat input predictions showed better agreement with engine test data than did the power predictions. Concerning all data points, the error in predicting the GPU-3 brake power was significantly larger than for the other engines and was mainly a result of inaccuracy in predicting the pressure phase angle. Analysis into this pressure phase angle prediction error suggested that improvements to the cylinder hysteresis loss model could have a significant effect on overall Stirling engine performance predictions.

  18. ISDN at NASA Lewis Research Center

    NASA Technical Reports Server (NTRS)

    Bakes, Catherine Murphy; Goldberg, Fredric; Eubanks, Steven W.

    1992-01-01

    An expository investigation of the potential impact of the Integrated Services Digital Network (ISDN) at NASA Lewis Research Center is described. To properly frame the subject, the paper contains a detailed survey of the components of Narrowband ISDN. The principles and objectives are presented as decreed by the Consultative Committee for International Telephone and Telegraph (CCITT). The various channel types are delineated and their associated service combinations are described. The subscriber-access network functions are explained pictorially via the ISDN reference configuration. A section on switching techniques is presented to enable the reader to understand the emergence of the concept of fast packet switching. This new technology is designed to operate over the high bandwidth, low error rate transmission media that characterizes the LeRC environment. A brief introduction to the next generation of networks is covered with sections on Broadband ISDM (B-ISDN), Asynchronous Transfer Mode (ATM), and Synchronous Optical Networks (SONET). Applications at LeRC are presented, first in terms of targets of opportunity, then in light of compatibility constraints. In-place pilot projects and testing are described that demonstrate actual usage at LeRC.

  19. Lewy body pathology in fetal grafts.

    PubMed

    Chu, Yaping; Kordower, Jeffrey H

    2010-01-01

    Although fetal nigral transplants have been shown to survive grafting into the striatum, increased [(18)F]6-fluroro-L-3,4-dihydroxyphenylalanine ((18)F-DOPA) uptake and improved motor function in open-label assessments have failed to establish any clinical benefits in double-blind, sham-controlled studies. To understand morphological and neurochemical alterations of grafted neurons, we performed postmortem analyses on six Parkinson's disease (PD) patients who had received fetal tissue transplantation 18-19 months, 4 years, and 14 years previously. These studies revealed robust neuronal survival with normal dopaminergic phenotypes in 18-month-old grafts and decreased dopamine transporter and increased cytoplasmic alpha-synuclein in 4-year-old grafts. We also found a decline of both dopamine transporter and tyrosine hydroxylase and the formation of Lewy body-like inclusions in 14-year-old grafts, which stained positive for alpha-synuclein and ubiquitin proteins. These pathological changes suggest that PD is an ongoing process that affects grafted cells in the striatum in a manner similar to how resident dopamine neurons are affected in the substantia nigra. PMID:20146690

  20. C.I. Lewis and Deming's theory of knowledge.

    PubMed

    Strickland, R

    1995-01-01

    W. Edwards Deming's theory of management has had significant impact on the way managers have understood their role in recent times. An important influence on his philosophy was the work of C.I. Lewis in an area of philosophy known as epistemology, or theory of knowledge. This article examines Lewis's influence on Deming, connects it to a larger intellectual context, and draws out the implications for the work of management. PMID:10143555

  1. 1. 1943 Plan View of 'Fort Lewis Station Hospital, Section ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. 1943 Plan View of 'Fort Lewis Station Hospital, Section No. 5.' Drawn by V. Steinbrueck for J.C. Boespflug Construction Co. July 23, 1943. HABS 8x10' negative was made from an 8.5 x 11' copy on card stock in the collection of the Community Library, Madigan Army Medical Center, Fort Lewis, WA. - Madigan Hospital, Bounded by Wilson & McKinley Avenues & Garfield & Lincoln Streets, DuPont, Pierce County, WA

  2. Lewis Research Center space station electric power system test facilities

    NASA Technical Reports Server (NTRS)

    Birchenough, Arthur G.; Martin, Donald F.

    1988-01-01

    NASA Lewis Research Center facilities were developed to support testing of the Space Station Electric Power System. The capabilities and plans for these facilities are described. The three facilities which are required in the Phase C/D testing, the Power Systems Facility, the Space Power Facility, and the EPS Simulation Lab, are described in detail. The responsibilities of NASA Lewis and outside groups in conducting tests are also discussed.

  3. Lewis acid enhanced emission of secondary molecular ions

    SciTech Connect

    Todd, P.J.; Leibman, C.P.; Mamantov, G.

    1985-01-01

    In aromatic/Lewis acid mixtures many aromatic compounds are ionized via a reversible one-electron oxidation to radical cations. For example, radical cations of aromatics having gas phase ionization energy (IE) less than 8 eV have been detected in AlCl/sub 3/ solutions by using ESR. Such systems are analogous to the protonation of organic bases in glycerol solution. Lewis acids were thus investigated as matrices to enhance secondary emission of molecular ions. 2 refs., 2 tabs.

  4. Alpha-synuclein inclusions in Alzheimer and Lewy body diseases.

    PubMed

    Mukaetova-Ladinska, E B; Hurt, J; Jakes, R; Xuereb, J; Honer, W G; Wischik, C M

    2000-05-01

    Alpha-synuclein has assumed particular neuropathological interest in the light both of its identification as a non-beta-amyloid plaque constituent in Alzheimer disease (AD), and the recent association between dominant inheritance of Parkinson disease (PD) and 2 missense mutations at positions 30 and 53 of the synuclein protein. We report a systematic study of alpha-synuclein, tau, and ubiquitin immunoreactivity in representative neurodegenerative disorders of late life. The alpha-synuclein association with Lewy bodies is variable, peripheral, and is not stable with respect to proteases or acid treatment, whereas there is no association with Pick bodies. Stable patterns of immunoreactivity included neurites and a novel inclusion body. Although there is an overlap between the presence of Lewy bodies and stable alpha-synuclein immunoreactivity, this is seen only in the presence of concomitant neuropathological features of AD. The novel alpha-synuclein inclusion body identified in pyramidal cells of the medial temporal lobe in particular was found in AD and in the Lewy body variant of AD, and was associated neither with ubiquitin nor tau protein. The inclusion is therefore neither a Lewy body nor a PHF-core body, but may be confused with the Lewy body, particularly in the Lewy body variant of AD. Abnormal processing of alpha-synuclein leading to its deposition in the form of proteolytically stable deposits is a particular feature of the intermediate stages of AD. PMID:10888371

  5. Capgras syndrome in Dementia with Lewy Bodies

    PubMed Central

    Thaipisutikul, Papan; Lobach, Iryna; Zweig, Yael; Gurnani, Ashita; Galvin, James E.

    2014-01-01

    Background Capgras syndrome is characterized by the recurrent, transient belief that a person has been replaced by an identical imposter. We reviewed clinical characteristics of Dementia with Lewy Bodies (DLB) patients with Capgras syndrome compared to those without Capgras. Methods We identified 55 consecutive DLB patients (11 cases with Capgras syndrome (DLB-C) and 44 cases without evidence of Capgras (DLB). Semi-structured interviews with the patient and an informant, neurological exams, and neuropsychological testing were performed. Caregivers were assessed for caregiver burden and depression. Primary comparisons were made between DLB-C and DLB. Exploratory analyses using stepwise logistic regression and bootstrap analyses were performed to determine clinical features associated with Capgras. Results DLB-C patients experienced more visual hallucinations and self-reported anxiety, had higher scores on the Neuropsychiatric Inventory, and were less likely to be treated with cholinesterase inhibitors at time of initial evaluation. Extrapyramidal symptoms and depression were not associated with Capgras. Caregivers of DLB-C patients had higher caregiver burden. DLB-C was associated with self-reported anxiety (OR 10.9; 95% CI 2.6-47.6). In a bootstrap analysis, clinical findings that were predictors of Capgras included visual hallucinations (log(OR) 18.3; 95% CI 17.9-19.3) and anxiety (log(OR) 2.9; 95% CI (0.31-20.2). Conclusions Our study suggests that Capgras syndrome is common in DLB and usually occurs in the presence of anxiety and visual hallucinations, suggesting related etiopathogenesis. Early appreciation of Capgras syndrome may afford the opportunity to alleviate caregiver burden and improve patient and caregiver outcomes. PMID:23211760

  6. Neuroimaging characteristics of dementia with Lewy bodies

    PubMed Central

    2014-01-01

    This review summarises the findings and applications from neuroimaging studies in dementia with Lewy bodies (DLB), highlighting key differences between DLB and other subtypes of dementia. We also discuss the increasingly important role of imaging biomarkers in differential diagnosis and outline promising areas for future research in DLB. DLB shares common clinical, neuropsychological and pathological features with Parkinson’s disease dementia and other dementia subtypes, such as Alzheimer’s disease. Despite the development of consensus diagnostic criteria, the sensitivity for differential diagnosis of DLB in clinical practice remains low and many DLB patients will be misdiagnosed. The importance of developing accurate imaging markers in dementia is highlighted by the potential for treatments targeting specific molecular abnormalities as well as the responsiveness to cholinesterase inhibitors and marked neuroleptic sensitivity of DLB. We review various brain imaging techniques that have been applied to investigate DLB, including the characteristic nigrostriatal degeneration in DLB using positron emission tomography (PET) and single-photon emission computed tomography (SPECT) tracers. Dopamine transporter loss has proven to reliably differentiate DLB from other dementias and has been incorporated into the revised clinical diagnostic criteria for DLB. To date, this remains the 'gold standard' for diagnostic imaging of DLB. Regional cerebral blood flow, 18 F-fluorodeoxygluclose-PET and SPECT have also identified marked deficits in the occipital regions with relative sparing of the medial temporal lobe when compared to Alzheimer’s disease. In addition, structural, diffusion, and functional magnetic resonance imaging techniques have shown alterations in structure, white matter integrity, and functional activity in DLB. We argue that the multimodal identification of DLB-specific biomarkers has the potential to improve ante-mortem diagnosis and contribute to our understanding of the pathological background of DLB and its progression. PMID:25031634

  7. Lewis inverse design code (LINDES): Users manual

    NASA Technical Reports Server (NTRS)

    Sanz, Jose M.

    1987-01-01

    The method of complex characteristics and hodograph transformation for the design of shockless airfoils was introduced by Bauer, Garabedian, and Korn and has been extended by the author to design subcritical and supercritical cascades with high solidities and large inlet angles. This new capability was achieved by introducing a new conformal mapping of the hodograph domain onto an ellipse and expanding the solution in terms of Chebyshev polynomials. A new computer code, the NASA Lewis inverse design code, was developed based on this idea. This new design code is an efficient method for the design of airfoils in cascade. In particular, the design of subcritical cascades of airfoils is a very fast, robust, and versatile process. The inverse design code can be made to interact with a turbulent boundary layer calculation to obtain airfoils with no separated flows at the design condition. This report is intended to serve as a users manual for this design code. Material previously reported by the author is included here for completeness and quick access to the user. The manual contains a description of the method followed by a discussion of the design procedure and examples. The input parameters necessary to run the code are then described and their default values given. Output listings corresponding to six different blade shapes designed with the code are given, as well as the necessary input data to reproduce the computer runs. The examples have been chosen to show that a wide range of applications can be covered with the code, ranging from supercritical propeller sections to wind tunnel turning vanes that can operate with a large inlet flow angle range.

  8. Pareidolias: complex visual illusions in dementia with Lewy bodies.

    PubMed

    Uchiyama, Makoto; Nishio, Yoshiyuki; Yokoi, Kayoko; Hirayama, Kazumi; Imamura, Toru; Shimomura, Tatsuo; Mori, Etsuro

    2012-08-01

    Patients rarely experience visual hallucinations while being observed by clinicians. Therefore, instruments to detect visual hallucinations directly from patients are needed. Pareidolias, which are complex visual illusions involving ambiguous forms that are perceived as meaningful objects, are analogous to visual hallucinations and have the potential to be a surrogate indicator of visual hallucinations. In this study, we explored the clinical utility of a newly developed instrument for evoking pareidolic illusions, the Pareidolia test, in patients with dementia with Lewy bodies-one of the most common causes of visual hallucinations in the elderly. Thirty-four patients with dementia with Lewy bodies, 34 patients with Alzheimer's disease and 26 healthy controls were given the Pareidolia test. Patients with dementia with Lewy bodies produced a much greater number of pareidolic illusions compared with those with Alzheimer's disease or controls. A receiver operating characteristic analysis demonstrated that the number of pareidolias differentiated dementia with Lewy bodies from Alzheimer's disease with a sensitivity of 100% and a specificity of 88%. Full-length figures and faces of people and animals accounted for >80% of the contents of pareidolias. Pareidolias were observed in patients with dementia with Lewy bodies who had visual hallucinations as well as those who did not have visual hallucinations, suggesting that pareidolias do not reflect visual hallucinations themselves but may reflect susceptibility to visual hallucinations. A sub-analysis of patients with dementia with Lewy bodies who were or were not treated with donepzil demonstrated that the numbers of pareidolias were correlated with visuoperceptual abilities in the former and with indices of hallucinations and delusional misidentifications in the latter. Arousal and attentional deficits mediated by abnormal cholinergic mechanisms and visuoperceptual dysfunctions are likely to contribute to the development of visual hallucinations and pareidolias in dementia with Lewy bodies. PMID:22649179

  9. Comparative assessment of the organization of the colors of the Vita Classical color pallet by digital images and visual analysis for dental bleaching

    NASA Astrophysics Data System (ADS)

    Oliveira-Júnior, O. B.; Cioffi, Mariana S.; Cesnik, R. M.; Florez, Fernando L. E.; Bagnato, Vanderlei S.; Corrêa-dos-Santos, Diego R.; Fornazari, Fabio P.

    2009-02-01

    New formularizations, techniques and devices have become the dental whitening most safe and with better results. Although this, the verification of the levels whitening is being continued for visual comparison, that is an empirical, subjective method, subject to errors and dependent of the individual interpretation. Normally the result of the whitening is express for the amplitude of displacement between the initial and the final color, being take like reference the tonalities of a scale of color commanded of darkest for more clearly. Although to be the most used scale , the ordinance of the Vita Classical ® - Vita, according to recommendations of the manufacturer, reveals inadequate for the evaluation of the whitening. From digital images and of algorithm OER (ordinance of the reference scale), especially developed for the ScanWhite ©, the ordinance of the tonalities of the scale Vita Classical® was made. For such, the values of the canals of color R, G, and B of medium part average of the crowns was adopted as reference for evaluation. The images had been taken with the camera Sony Cybershoot DSC F828. The results of the computational ordinance had been compared with the sequence proposal for the manufacturer and with the earned one for the visual evaluation, carried through by 10 volunteers, under standardized conditions of illumination. It statistics analyzes demonstrated significant differences between the ordinances.

  10. The spectrum of cognitive impairment in Lewy body diseases

    PubMed Central

    Goldman, Jennifer G.; Williams-Gray, Caroline; Barker, Roger A.; Duda, John E.; Galvin, James E.

    2014-01-01

    Cognitive impairment represents an important and often defining component of the clinical syndromes of Lewy body disorders: Parkinson’s disease and dementia with Lewy bodies. The spectrum of cognitive deficits in these Lewy body diseases encompasses a broad range of clinical features, severity of impairment, and timing of presentation. Cognitive dysfunction is now recognized to occur not only in more advanced Parkinson’s disease, but also in early, untreated patients, and even in those patients with pre-motor syndromes such as REM behavior disorder and hyposmia. In recent years, the concept of “mild cognitive impairment” as a transitional or pre-dementia state in Parkinson’s disease has emerged. While this has led to much research regarding the diagnosis, prognosis, and underlying neurobiology of mild cognitive impairment in Parkinson’s disease, it has also raised questions regarding the usefulness of this concept and its application in clinical and research settings. In addition, the conundrum of whether Parkinson’s disease dementia and dementia with Lewy bodies represent the same or different entities remains unresolved. While these disorders overlap in many aspects of their presentations and pathophysiology, they differ in other aspects such as timing of cognitive, behavioral, and motor symptoms, medication responses, and neuropathological contributions. This article examines the spectrum and evolution of cognitive impairment in Lewy body disorders and debates these controversial issues in the field using point-counterpoint approaches. PMID:24757110

  11. The relative playfulness of juvenile Lewis and Fischer-344 rats.

    PubMed

    Siviy, Stephen M; Love, Nicole J; DeCicco, Brian M; Giordano, Sara B; Seifert, Tara L

    2003-11-01

    The relative playfulness of inbred Lewis and Fischer-344 rats was characterized. Fischer rats were consistently less playful than Lewis rats, with rats of this strain less likely to initiate playful interactions with either responsive or unresponsive partners and also less likely to respond playfully when playful solicitations were directed to them. While less playful, Fischer rats were more socially inquisitive than Lewis rats when tested with an unresponsive partner, suggesting that Fischer rats are less likely to escalate a social encounter into a playful one. Strain differences in playful responsiveness were present with or without prior social isolation, suggesting that this aspect of play represents a relatively stable trait difference. Unlike play responsiveness, strain differences in play solicitation were only apparent after a period of social isolation. Low levels of play were still present in Fischer rats that had been reared by Lewis dams, suggesting a genetic source for the altered play in rats of this strain. Further studies of play behavior in Lewis and Fischer rats could illuminate relevant neural involvement in rough-and-tumble play and also help understand the genetic bases for this complex social behavior. PMID:14637239

  12. Lewis rats have greater response impulsivity than Fischer rats

    PubMed Central

    Hamilton, Kristen R.; Potenza, Marc N.; Grunberg, Neil E.

    2014-01-01

    Impulsivity, a tendency toward immediate action without consideration of future consequences, is associated with a wide array of problematic behaviors. Response impulsivity, a type of behaviorally-assessed impulsivity characterized by behavioral disinhibition, is also associated with health risk behaviors. Response impulsivity is distinct from choice impulsivity, which is characterized by intolerance for delay. Lewis rats have higher levels of choice impulsivity than Fischer rats (Anderson & Woolverton, 2005; Madden et al., 2008; Stein et al., 2012). However, no studies have examined whether Lewis and Fischer rats have different levels of response impulsivity. The present research examined response impulsivity in the two rat strains. Subjects were 16 male Lewis and Fischer rats. Rats’ response impulsivity was measured using the Five Choice Serial Reaction Time Task (5-CSRTT). In addition, their locomotor activity was measured in locomotor activity chambers. Lewis rats had more premature responses than Fischer rats during the 5-CSRTT assessment [F(1, 14) = 5.34, p < 0.05], indicating higher levels of response impulsivity. Locomotor activity did not differ between rat strain groups [F(1, 14) = 3.05, p = .10], suggesting that overall movement did not account for group differences in response impulsivity on the 5-CSRTT. It can be concluded from this research that Lewis rats have higher levels of response impulsivity than Fischer rats, and therefore provide a valid rat model of individual differences in impulsivity. PMID:24613059

  13. Risk factors for dementia with Lewy bodies

    PubMed Central

    Boot, Brendon P.; Orr, Carolyn F.; Ahlskog, J. Eric; Ferman, Tanis J.; Roberts, Rosebud; Pankratz, Vernon S.; Dickson, Dennis W.; Parisi, Joseph; Aakre, Jeremiah A.; Geda, Yonas E.; Knopman, David S.; Petersen, Ronald C.

    2013-01-01

    Objective: To determine the risk factors associated with dementia with Lewy bodies (DLB). Methods: We identified 147 subjects with DLB and sampled 2 sex- and age-matched cognitively normal control subjects for each case. We also identified an unmatched comparison group of 236 subjects with Alzheimer disease (AD). We evaluated 19 candidate risk factors in the study cohort. Results: Compared with controls, subjects with DLB were more likely to have a history of anxiety (odds ratio; 95% confidence interval) (7.4; 3.5–16; p < 0.0001), depression (6.0; 3.7–9.5; p < 0.0001), stroke (2.8; 1.3–6.3; p = 0.01), a family history of Parkinson disease (PD) (4.6; 2.5–8.6; p < 0.0001), and carry APOE ε4 alleles (2.2; 1.5–3.3; p < 0.0001), but less likely to have had cancer (0.44; 0.27–0.70; p = 0.0006) or use caffeine (0.29; 0.14–0.57; p < 0.0001) with a similar trend for alcohol (0.65; 0.42–1.0; p = 0.0501). Compared with subjects with AD, subjects with DLB were younger (72.5 vs 74.9 years, p = 0.021) and more likely to be male (odds ratio; 95% confidence interval) (5.3; 3.3–8.5; p < 0.0001), have a history of depression (4.3; 2.4–7.5; p < 0.0001), be more educated (2.5; 1.1–5.6; p = 0.031), have a positive family history of PD (5.0; 2.4–10; p < 0.0001), have no APOE ε4 alleles (0.61; 0.40–0.93; p = 0.02), and to have had an oophorectomy before age 45 years (7.6; 1.5–39; p = 0.015). Conclusion: DLB risk factors are an amalgam of those for AD and PD. Smoking and education, which have opposing risk effects on AD and PD, are not risk factors for DLB; however, depression and low caffeine intake, both risk factors for AD and PD, increase risk of DLB more strongly than in either. PMID:23892702

  14. Lewy Bodies: A Spectator or Salient Killer?

    PubMed

    Sian-Hulsmann, Jeswinder; Monoranu, Camelia; Strobel, S; Riederer, Peter

    2015-01-01

    Lewy bodies (LBs) are characteristic hallmarks of Parkinson's disease (PD). However, their role in the pathology of PD is not established yet. Are they primary events in the neurodegenerative process or only secondary phenomena? Are they signs of protecting neurons from toxicity or are they toxic per se? How are they are formed? Are LBs targets for therapeutic strategies? Addressing these questions may be of pivotal importance to unravel the basic mechanisms of neurodegeneration in PD. On the basis of current evidence, we intend to elucidate the possible role of LBs as triggers and/or markers of disease progression in PD. We present evidence for the morphogenesis of brain stem and cortical LBs, the role in neuronal cell death mechanisms, which seem to be correlated with the adhesion of LBs to and finally disruption of their inner neuronal membrane. Taken as such, LBs would be salient killers of nerve cells. However, they may also play a neuroprotective role in the early phases of neuronal pathology (LBs as a spectator), yet harmful to neuronal stability in later stages of LB development. Generation of LB pathology in the periphery (early subclinical Braak stage) might be due to reactive oxygen species (ROS) due to (chronic) bacteria-induced and/or otherwise intestinal inflammation, both leading to alpha-synuclein structural changes, oligomerization, seeding and propagation in a prion-like mechanism. If so, LB generation is a secondary process following ROS/inflammation pathology. Therapeutic implication based on LB pathology include drug development to inhibit protein misfolding, templating and transmission or vaccination against LBs, neuron regeneration strategies, anti-inflammatory and anti-biotic drugs as well as nutritional specialities to prevent intestine intoxications. In conclusion, evidence suggests LBs to be secondary hallmarks of PD pathology, induced by ROS/inflammation or other pathological triggers able to modify protein (alpha-synuclein) steric/chemical properties. Therapeutic strategies based on LB pathologies are devoted to reduce neuron cell death mechanisms in their time course and severity. PMID:25801839

  15. For an indeterministic ethics. The emptiness of the rule in dubio pro vita and life cessation decisions

    PubMed Central

    Pavlovic, Dragan; Lehmann, Christian; Wendt, Michael

    2009-01-01

    It is generally claimed that there exist exceptional circumstances when taking human life may be approved and when such actions may be justified on moral grounds. Precise guidelines in the medical field for making such decisions concerning patients who are terminally ill or have irreparable injuries incompatible with a bearable life, are difficult to establish. Recommendations that take the particular logical form of a rule, such as "in dubio pro vita", "when in doubt favour life") have been suggested and in some countries incorporated into legal texts (Germany). We claim here that such a rule is of no value since it is open-ended and always allows for doubt, and a decision to employ measures that would support human life could always be argued to be a valid choice. Preservation of this rule could be encouraged, but giving it the force of law may put physicians at risk, as they may be challenged for choosing to terminate life in otherwise ethically and medically uncontroversial circumstances. PMID:19442284

  16. Theoretical model for VITA-educed coherent structures in the wall region of a turbulent boundary layer

    NASA Technical Reports Server (NTRS)

    Landahl, Marten T.

    1988-01-01

    Experiments on wall-bounded shear flows (channel flows and boundary layers) have indicated that the turbulence in the region close to the wall exhibits a characteristic intermittently formed pattern of coherent structures. For a quantitative study of coherent structures it is necessary to make use of conditional sampling. One particularly successful sampling technique is the Variable Integration Time Averaging technique (VITA) first explored by Blackwelder and Kaplan (1976). In this, an event is assumed to occur when the short time variance exceeds a certain threshold multiple of the mean square signal. The analysis presented removes some assumptions in the earlier models in that the effects of pressure and viscosity are taken into account in an approximation based on the assumption that the near-wall structures are highly elongated in the streamwise direction. The appropriateness of this is suggested by the observations but is also self consistent with the results of the model which show that the streamwise dimension of the structure grows with time, so that the approximation should improve with the age of the structure.

  17. Habitat Selection and Reproductive Success of Lewis's Woodpecker (Melanerpes lewis) at Its Northern Limit

    PubMed Central

    Zhu, Xiang; Srivastava, Diane S.; Martin, Kathy

    2012-01-01

    Lewis's Woodpecker (Melanerpes lewis) has experienced population declines in both Canada and the United States and in 2010 was assigned a national listing of threatened in Canada. We conducted a two-year study (2004–2005) of this species at its northern range limit, the South Okanagan Valley in British Columbia, Canada. Our main objective was to determine whether the habitat features that influenced nest-site selection also predicted nest success, or whether other factors (e.g. cavity dimensions, clutch initiation date or time of season) were more important. Nest tree decay class, density of suitable cavities and total basal area of large trees were the best predictors of nest-site selection, but these factors were unrelated to nesting success. Estimates of demographic parameters (mean ± SE) included daily nest survival rate (0.988±0.003, years combined), nest success (0.52±0.08), clutch size (5.00±0.14 eggs), female fledglings per successful nest (1.31±0.11), and annual productivity (0.68±0.12 female fledglings per nest per year). Although higher nest survival was associated with both early and late initiated clutches, early-initiated clutches allowed birds to gain the highest annual productivity as early clutches were larger. Nests in deep cavities with small entrances experienced lower predation risk especially during the peak period of nest predation. We concluded that nest-site selection can be predicted by a number of easily measured habitat variables, whereas nest success depended on complicated ecological interactions among nest predators, breeding behaviors, and cavity features. Thus, habitat-based conservation strategies should also consider ecological factors that may not be well predicted by habitat. PMID:23028525

  18. Sudden Death: An Uncommon Occurrence in Dementia with Lewy Bodies.

    PubMed

    Molenaar, Joery P; Wilbers, Joyce; Aerts, Marjolein B; Leijten, Quinten H; van Dijk, Jan G; Esselink, Rianne A; Bloem, Bastiaan R

    2016-01-01

    We present a 75-year-old woman with dementia and parkinsonism who developed severe orthostatic hypotension and eventually died. Autopsy revealed extensive Lewy body formation in the midbrain, limbic system, intermediate spinal cord, and medulla oblongata. Furthermore, a vast amount of Lewy bodies was seen in the paravertebral sympathetic ganglia which likely explained the severe autonomic failure. We speculate that this autonomic failure caused sudden death through dysregulation of respiration or heart rhythm, reminiscent of sudden death in multiple system atrophy (MSA). Clinicians should be aware of this complication in patients presenting with parkinsonism and autonomic dysfunction, and that sudden death may occur in dementia with Lewy bodies (DLB) as it does in MSA. PMID:26891177

  19. Effects of non-unity Lewis numbers in diffusion flames

    NASA Technical Reports Server (NTRS)

    Linan, A.; Orlandi, P.; Verzicco, R.; Higuera, F. J.

    1994-01-01

    The purpose of this work is to carry out direct numerical simulations of diffusion controlled combustion with non-unity Lewis numbers for the reactants and products, thus accounting for the differential diffusion effects of the temperature and concentration fields. We use a formulation based on combining the conservation equations in a way to eliminate the reaction terms similar to the method used by Burke and Schumann (1928) for unity Lewis numbers. We present calculations for an axisymmetric fuel jet and for a planar, time evolving mixing layer, leaving out the effects of thermal expansion and variations of the transport coefficients due to the heat release. Our results show that the front of the flame shifts toward the fuel or oxygen sides owing to the effect of the differential diffusion and that the location of maximum temperature may not coincide with the flame. The dependence of the distribution of the reaction products on their Lewis number has been investigated.

  20. Helicopter transmission testing at NASA Lewis Research Center

    NASA Technical Reports Server (NTRS)

    Lewicki, David G.; Coy, John J.

    1987-01-01

    The helicopter has evolved into a highly valuable air mobile vehicle for both military and civilian needs. The helicopter transmission requires advanced studies to develop a technology base for future rotorcraft advances. A joint helicopter transmission research program between the NASA Lewis Research Center and the U.S. Army Aviation Systems Command has existed since 1970. Program goals are to reduce weight and noise and to increase life and reliability. The current experimental activities at Lewis consist of full-scale helicopter transmission testing, a base effort in gearing technology, and a future effort in noise reduction technology. The experimental facilities at Lewis for helicopter transmission testing are described. A description of each of the rigs is presented along with some significant results and near-term plans.

  1. Global Climate Model Simulated Hydrologic Droughts and Floods in the Nelson-Churchill Watershed

    NASA Astrophysics Data System (ADS)

    Vieira, M. J. F.; Stadnyk, T. A.; Koenig, K. A.

    2014-12-01

    There is uncertainty surrounding the duration, magnitude and frequency of historical hydroclimatic extremes such as hydrologic droughts and floods prior to the observed record. In regions where paleoclimatic studies are less reliable, Global Climate Models (GCMs) can provide useful information about past hydroclimatic conditions. This study evaluates the use of Coupled Model Intercomparison Project 5 (CMIP5) GCMs to enhance the understanding of historical droughts and floods across the Canadian Prairie region in the Nelson-Churchill Watershed (NCW). The NCW is approximately 1.4 million km2 in size and drains into Hudson Bay in Northern Manitoba, Canada. One hundred years of observed hydrologic records show extended dry and wet periods in this region; however paleoclimatic studies suggest that longer, more severe droughts have occurred in the past. In Manitoba, where hydropower is the primary source of electricity, droughts are of particular interest as they are important for future resource planning. Twenty-three GCMs with daily runoff are evaluated using 16 metrics for skill in reproducing historic annual runoff patterns. A common 56-year historic period of 1950-2005 is used for this evaluation to capture wet and dry periods. GCM runoff is then routed at a grid resolution of 0.25° using the WATFLOOD hydrological model storage-routing algorithm to develop streamflow scenarios. Reservoir operation is naturalized and a consistent temperature scenario is used to determine ice-on and ice-off conditions. These streamflow simulations are compared with the historic record to remove bias using quantile mapping of empirical distribution functions. GCM runoff data from pre-industrial and future projection experiments are also bias corrected to obtain extended streamflow simulations. GCM streamflow simulations of more than 650 years include a stationary (pre-industrial) period and future periods forced by radiative forcing scenarios. Quantile mapping adjusts for magnitude only while maintaining the GCM's sequencing of events, allowing for the examination of differences in historic and future hydroclimatic extremes. These bias corrected streamflow scenarios provide an alternative to stochastic simulations for hydrologic data analysis and can aid future resource planning and environmental studies.

  2. Bibliography of Lewis Research Center technical contributions announced in 1976

    NASA Technical Reports Server (NTRS)

    1977-01-01

    Abstracts of Lewis authored publications and publications resulting from Lewis managed contracts which were announced in the 1976 issues of STAR (Scientific and Technical Aerospace Reports) and IAA (International Aerospace Abstracts) are presented. Research reports, journal articles, conference presentations, patents and patent applications, and these are included. The arrangement is by NASA subject category. Citations indicate report literature (identified by their N-numbers) and the journal and conference presentations (identified by their A-numbers). A grouping of indexes helps locate specific publications by author (including contractor authors), contractor organization, contract number, and report number.

  3. Space Chemical Propulsion Test Facilities at NASA Lewis Research Center

    NASA Technical Reports Server (NTRS)

    Urasek, Donald C.; Calfo, Frederick D.

    1993-01-01

    The NASA Lewis Research Center, located in Cleveland, Ohio, has a number of space chemical propulsion test facilities which constitute a significant national space testing resource. The purpose of this paper is to make more users aware of these test facilities and to encourage their use through cooperative agreements between the government, industry, and universities. Research which is of interest to the government is especially encouraged and often can be done in a cooperative manner that best uses the resources of all parties. An overview of the Lewis test facilities is presented.

  4. Summary of Research Report Lewis Incubator for Technology

    NASA Technical Reports Server (NTRS)

    Zeman, Wayne P.

    2000-01-01

    This report summarizes the work done to establish and operate the Lewis Incubator for Technology (LIFT) for the period July 1996 through September 2000. The Lewis Incubator helps the startup and growth of technology-based businesses with the potential to incorporate technology from the NASA Glenn Research Center. During the grant period, LIFT began operation, met or exceeded all key performance measures, and continues its operation through a new cooperative agreement with NASA Glenn and also through continued funding from the State of Ohio.

  5. Gear and Transmission Research at NASA Lewis Research Center

    NASA Technical Reports Server (NTRS)

    Townsend, Dennis P.

    1997-01-01

    This paper is a review of some of the research work of the NASA Lewis Research Center Mechanical Components Branch. It includes a brief review of the NASA Lewis Research Center and the Mechanical Components Branch. The research topics discussed are crack propagation of gear teeth, gear noise of spiral bevel and other gears, design optimization methods, methods we have investigated for transmission diagnostics, the analytical and experimental study of gear thermal conditions, the analytical and experimental study of split torque systems, the evaluation of several new advanced gear steels and transmission lubricants and the evaluation of various aircraft transmissions. The area of research needs for gearing and transmissions is also discussed.

  6. Utilization of NASA Lewis mobile terminals for the Hermes satellite

    NASA Technical Reports Server (NTRS)

    Edelman, E. A.; Fiala, J. L.; Rizzolla, L.

    1977-01-01

    The high power of the Hermes satellite enables two-way television and voice communication with small ground terminals. The Portable Earth Terminal (PET) and the Transportable Earth Terminal (TET) were developed and built by NASA-Lewis to provide communications capability to short-term users. The NASA-Lewis mobile terminals are described in terms of vehicles and onboard equipment, as well as operation aspects, including use in the field. The section on demonstrations divides the uses into categories of medicine, education, technology and government. Applications of special interest within each category are briefly described.

  7. A revision of Megalocraerus Lewis, 1902 (Coleoptera, Histeridae: Exosternini)

    PubMed Central

    Caterino, Michael S.; Tishechkin, Alexey K.

    2016-01-01

    Abstract The formely monotypic Neotropical genus Megalocraerus Lewis is revised to include five species, known from southeastern Brazil to Costa Rica: Megalocraerus rubricatus Lewis, Megalocraerus mandibularis sp. n., Megalocraerus chico sp. n., Megalocraerus madrededios sp. n., and Megalocraerus tiputini sp. n. We describe the species, map their distributions, and provide a key for their identification. Their subcylindrical body form and emarginate mesosternum have previously hindered placement to tribe, although their curent assignment to Exosternini now appears well supported by morphological evidence. Nothing is known of the natural history of the species. PMID:26877699

  8. Research and technology highlights of the Lewis Research Center

    NASA Technical Reports Server (NTRS)

    1984-01-01

    Highlights of research accomplishments of the Lewis Research Center for fiscal year 1984 are presented. The report is divided into four major sections covering aeronautics, space communications, space technology, and materials and structures. Six articles on energy are included in the space technology section.

  9. Neural correlates of psychotic symptoms in dementia with Lewy bodies.

    PubMed

    Nagahama, Yasuhiro; Okina, Tomoko; Suzuki, Norio; Matsuda, Minoru

    2010-02-01

    The aim of this study was to investigate the association between psychotic symptoms in dementia with Lewy bodies and brain perfusion on single photon emission tomography. Based on factor analysis in 145 patients, psychotic symptoms were classified into five symptom domains (factor 1 to 4-related symptoms and delusions). The relationship between each symptom domain and brain perfusion was assessed in 100 patients with dementia with Lewy bodies, while accounting for the effects of age, sex, dementia severity, parkinsonism and dysphoria. Factor 1 symptoms (Capgras syndrome, phantom boarder, reduplication of person and place and misidentification of person) represented misidentifications, and were significantly related to hypoperfusion in the left hippocampus, insula, ventral striatum and bilateral inferior frontal gyri. Factor 3 symptoms (visual hallucination of person and feeling of presence) represented hallucinations of person and were related to hypoperfusion in the left ventral occipital gyrus and bilateral parietal areas. Delusions of theft and persecution were associated with relative hyperperfusion in the right rostral medial frontal cortex, left medial superior frontal gyrus and bilateral dorsolateral frontal cortices. This study revealed that different psychotic symptoms in dementia with Lewy bodies were associated with distinguishable cerebral networks. Visual hallucinations were related to dysfunction of the parietal and occipital association cortices, misidentifications were related to dysfunction of the limbic-paralimbic structures and delusions were related to dysfunction of the frontal cortices. Our findings provide important insights into the pathophysiological mechanisms underlying psychotic symptoms in dementia with Lewy bodies. PMID:19920063

  10. Bibliography of Lewis Research Center technical publications announced in 1983

    NASA Technical Reports Server (NTRS)

    1984-01-01

    This compilation of abstracts describes and indexes over 800 technical publications that resulted from the scientific and engineering work performed and managed by the Lewis Research Center in 1983. Announced in the 1983 issues of STAR (Scientific and Technical Aerospace Reports) and/or IAA (International Aerospace Abstracts), the documents cited include research reports, journal articles, conference presentations, patents and patent applications, and theses.

  11. Cholinesterase Inhibitors for Lewy Body Disorders: A Meta-Analysis

    PubMed Central

    Yasue, Ichiro; Iwata, Nakao

    2016-01-01

    Background: We performed a meta-analysis of cholinesterase inhibitors for patients with Lewy body disorders, such as Parkinson’s disease, Parkinson’s disease dementia, and dementia with Lewy bodies. Methods: The meta-analysis included only randomized controlled trials of cholinesterase inhibitors for Lewy body disorders. Results: Seventeen studies (n = 1798) were assessed. Cholinesterase inhibitors significantly improved cognitive function (standardized mean difference [SMD] = −0.53], behavioral disturbances (SMD = −0.28), activities of daily living (SMD = −0.28), and global function (SMD = −0.52) compared with control treatments. Changes in motor function were not significantly different from control treatments. Furthermore, the cholinesterase inhibitor group had a higher all-cause discontinuation (risk ratio [RR] = 1.48, number needed to harm [NNH] = 14), discontinuation due to adverse events (RR = 1.59, NNH = 20), at least one adverse event (RR = 1.13, NNH = 11), nausea (RR = 2.50, NNH = 13), and tremor (RR = 2.30, NNH = 20). Conclusions: Cholinesterase inhibitors appear beneficial for the treatment of Lewy body disorders without detrimental effects on motor function. However, a careful monitoring of treatment compliance and side effects is required. PMID:26221005

  12. 168. Photocopy of Photograph (original in Roger Lewis' private collection). ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    168. Photocopy of Photograph (original in Roger Lewis' private collection). Photographer and date unknown. MILNER DAM TUNNEL CONSTRUCTION, TWIN FALLS COUNTY, MILNER, IDAHO; WORKERS STANDING IN TUNNEL (ONE CAN BE SEEN AT FAR END OF TUNNEL). - Milner Dam & Main Canal: Twin Falls Canal Company, On Snake River, 11 miles West of city of Burley, Idaho, Twin Falls, Twin Falls County, ID

  13. 175. Photocopy of Photograph (original in Roger Lewis' private collection). ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    175. Photocopy of Photograph (original in Roger Lewis' private collection). Photographer and date unknown. CENTER ISLAND, CRAWFORD WATER WHEEL, TWIN FALLS COUNTY, MILNER, IDAHO; LOOKING DOWNSTREAM FROM DAM SITE. - Milner Dam & Main Canal: Twin Falls Canal Company, On Snake River, 11 miles West of city of Burley, Idaho, Twin Falls, Twin Falls County, ID

  14. Effects of Lewis Number on Temperatures of Spherical Diffusion Flames

    NASA Technical Reports Server (NTRS)

    Santa, K. J.; Sun, Z.; Chao, B. H.; Sunderland, P. B.; Axelbaum, R. I.; Urban, D. L.; Stocker, D. P.

    2007-01-01

    Spherical diffusion flames supported on a porous sphere were studied numerically and experimentally. Experiments were performed in 2.2 s and 5.2 s microgravity facilities. Numerical results were obtained from a Chemkin-based program. The program simulates flow from a porous sphere into a quiescent environment, yields both steady-state and transient results, and accounts for optically thick gas-phase radiation. The low flow velocities and long residence times in these diffusion flames lead to enhanced radiative and diffusive effects. Despite similar adiabatic flame temperatures, the measured and predicted temperatures varied by as much as 700 K. The temperature reduction correlates with flame size but characteristic flow times and, importantly, Lewis number also influence temperature. The numerical results show that the ambient gas Lewis number would have a strong effect on flame temperature if the flames were steady and nonradiating. For example, a 10% decrease in Lewis number would increase the steady-state flame temperature by 200 K. However, for these transient, radiating flames the effect of Lewis number is small. Transient predictions of flame sizes are larger than those observed in microgravity experiments. Close agreement could not be obtained without either increasing the model s thermal and mass diffusion properties by 30% or reducing mass flow rate by 25%.

  15. Evaluation in Israel: A Conversation with Arieh Lewy.

    ERIC Educational Resources Information Center

    Bank, Adrianne

    1985-01-01

    Although evaluation practice in Israel is strongly influenced by American thinking, it is also a unique local response to societal, political, academic, cultural, and interpersonal pressures. In this interview Arieh Lewy discusses educational evaluation in Israel and the cultural context in which it operates. (Author/BS)

  16. 165. Photocopy of Photograph (original in Roger Lewis' private collection). ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    165. Photocopy of Photograph (original in Roger Lewis' private collection). Photographer and date unknown. MILNER DAM, TWIN FALLS COUNTY, MILNER IDAHO; CRANES USED TO PLACE ROCK ON DAM; NOTE ELECTRIC RAILROAD CAR AT LEFT. - Milner Dam & Main Canal: Twin Falls Canal Company, On Snake River, 11 miles West of city of Burley, Idaho, Twin Falls, Twin Falls County, ID

  17. 174. Photocopy of Photograph (original in Roger Lewis' private collection). ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    174. Photocopy of Photograph (original in Roger Lewis' private collection). Photographer and date unknown. SNAKE RIVER BELOW MILNER DAM SITE, TWIN FALLS COUNTY, MILNER, IDAHO; RAPIDS JUST BELOW MILNER TOWNSITE. - Milner Dam & Main Canal: Twin Falls Canal Company, On Snake River, 11 miles West of city of Burley, Idaho, Twin Falls, Twin Falls County, ID

  18. Bibliography of Lewis Research Center technical publications announced in 1980

    NASA Technical Reports Server (NTRS)

    1981-01-01

    This compilation of abstracts describes and indexes over 780 research reports, journal articles, conference presentations, patents and patent applications, and theses resulting from the scientific and engineering work performed and managed by the Lewis Research Center in 1980. All the publications were announced in Scientific and Technical Aerospace Reports and/or International Aerospace Abstracts.

  19. A Legacy of Dandelions: Carolyn Lewis Attneave (1990-1992).

    ERIC Educational Resources Information Center

    Heckman-Stone, Carolyn

    2000-01-01

    Discusses the legacy of Carolyn Lewis Attneave who was, according to T. D. LaFromboise and J. E. Trimble (1966), "undoubtedly the most well-known psychologist of American Indian background." Reviews Attneave's work in organizations across the United States promoting the causes of American Indian families and community mental health and her skill…

  20. Iron-catalyzed amination of alcohols assisted by Lewis acid.

    PubMed

    Pan, Hui-Jie; Ng, Teng Wei; Zhao, Yu

    2015-07-28

    An efficient Lewis acid-assisted, iron-catalyzed amination of alcohols using borrowing hydrogen methodology was developed. In particular, silver fluoride was identified to be a highly effective additive to overcome the low efficiency in the amination of secondary alcohols catalyzed by Knölker's complex. PMID:26111504

  1. A neurobiological nonalternative: rejoinder to Lewis, Baumeister, and Mailman.

    PubMed Central

    Newsom, C; Lovaas, O I

    1987-01-01

    Certain misrepresentations of our theory of self-stimulatory behavior by Lewis, Baumeister, and Mailman (1987) are corrected and several questions raised by the commentators are answered. Their proposed neurobiological alternative is considered briefly and judged to be insufficiently detailed, inadequate in scope, and therefore premature. PMID:3667476

  2. Alleged Mercury Discharge by the Lewis Research Center

    NASA Technical Reports Server (NTRS)

    Rosenbluum, L.

    1971-01-01

    Water sample analysis, site visits, and effluent reports are examined in an attempt to identify the sources contributing to mercury pollution of the Great Lakes. Two sources were identified, Lewis Research Center and Dow Chemical of Canada. Tests were made during a period from April to September 1970.

  3. Modified NASA-Lewis chemical equilibrium code for MHD applications

    NASA Technical Reports Server (NTRS)

    Sacks, R. A.; Geyer, H. K.; Grammel, S. J.; Doss, E. D.

    1979-01-01

    A substantially modified version of the NASA-Lewis Chemical Equilibrium Code was recently developed. The modifications were designed to extend the power and convenience of the Code as a tool for performing combustor analysis for MHD systems studies. The effect of the programming details is described from a user point of view.

  4. Impact of Predatory Threat on Fear Extinction in Lewis Rats

    ERIC Educational Resources Information Center

    Goswami, Sonal; Cascardi, Michele; Rodriguez-Sierra, Olga E.; Duvarci, Sevil; Pare, Denis

    2010-01-01

    Humans with post-traumatic stress disorder (PTSD) are deficient at extinguishing conditioned fear responses. A study of identical twins concluded that this extinction deficit does not predate trauma but develops as a result of trauma. The present study tested whether the Lewis rat model of PTSD reproduces these features of the human syndrome.…

  5. Q & A with Ed Tech Leaders: Interview with Brian Lewis

    ERIC Educational Resources Information Center

    Shaughnessy, Michael F.; Fulgham, Susan M.

    2013-01-01

    Brian Lewis, International Society for Technology in Education (ISTE) chief executive officer, is an education advocate and leader specializing in management and governance, policy, corporate communications, branding, and marketing. He provides leadership to ISTE's Washington, DC, and Eugene, Oregon, offices and directs organizational…

  6. 32 CFR 552.168 - Fort Lewis Area Access Office.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... RESERVATIONS AND NATIONAL CEMETERIES REGULATIONS AFFECTING MILITARY RESERVATIONS Land Use Policy for Fort Lewis... permits. The group leader permit is not transferable. (3) Events requiring commitment of land must be processed per § 552.166. (f) Aside from the land commitment coordination time requirement in §...

  7. 32 CFR 552.168 - Fort Lewis Area Access Office.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... RESERVATIONS AND NATIONAL CEMETERIES REGULATIONS AFFECTING MILITARY RESERVATIONS Land Use Policy for Fort Lewis... permits. The group leader permit is not transferable. (3) Events requiring commitment of land must be processed per § 552.166. (f) Aside from the land commitment coordination time requirement in §...

  8. 32 CFR 552.168 - Fort Lewis Area Access Office.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... RESERVATIONS AND NATIONAL CEMETERIES REGULATIONS AFFECTING MILITARY RESERVATIONS Land Use Policy for Fort Lewis... permits. The group leader permit is not transferable. (3) Events requiring commitment of land must be processed per § 552.166. (f) Aside from the land commitment coordination time requirement in §...

  9. 32 CFR 552.168 - Fort Lewis Area Access Office.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... RESERVATIONS AND NATIONAL CEMETERIES REGULATIONS AFFECTING MILITARY RESERVATIONS Land Use Policy for Fort Lewis... permits. The group leader permit is not transferable. (3) Events requiring commitment of land must be processed per § 552.166. (f) Aside from the land commitment coordination time requirement in §...

  10. Who Needs Lewis Structures to Get VSEPR Geometries?

    ERIC Educational Resources Information Center

    Lindmark, Alan F.

    2010-01-01

    Teaching the VSEPR (valence shell electron-pair repulsion) model can be a tedious process. Traditionally, Lewis structures are drawn and the number of "electron clouds" (groups) around the central atom are counted and related to the standard VSEPR table of possible geometries. A simpler method to deduce the VSEPR structure without first drawing

  11. 161. Photocopy of Photograph (original in Roger Lewis' private collection, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    161. Photocopy of Photograph (original in Roger Lewis' private collection, Twin Falls, Idaho). Photographer and date unknown. MILNER DAM, SOUTH SIDE CANAL, TWIN FALLS COUNTY, MILNER, IDAHO; WORKERS AT CAMP AT HEAD OF CANAL. - Milner Dam & Main Canal: Twin Falls Canal Company, On Snake River, 11 miles West of city of Burley, Idaho, Twin Falls, Twin Falls County, ID

  12. NASA. Lewis Research Center materials research and technology: An overview

    NASA Technical Reports Server (NTRS)

    Grisaffe, Salvatore J.

    1990-01-01

    The Materials Division at the Lewis Research Center has a long record of contributions to both materials and process technology as well as to the understanding of key high-temperature phenomena. This paper overviews the division staff, facilities, past history, recent progress, and future interests.

  13. Revisiting Lewis dot structure weightings: a pair density perspective.

    PubMed

    Ferro-Costas, David; Mosquera, Ricardo A

    2015-03-21

    A method based on a real space partitioning to measure the importance of Lewis structures is proposed in this work. A matrix containing diverse QTAIM atomic and diatomic properties endowed with significance within a Lewis structure framework is expanded in terms of what we call Lewis-structure matrices. Each of these matrices flawlessly describes an individual resonance structure and its associated linear expansion coefficient (Q-ALE coefficient) indicates the importance or convenience of the given Lewis structure. These coefficients were inspected looking at their evolution in a series of usual chemical issues. Among all the results, we find of interest that σ resonance structures in systems with π electrons are more important than normally expected, which justifies why the qualitative predictions arising from the application of the resonance model and the quantitative results based on QTAIM properties are sometimes discrepant. Likewise, we observe that the variation of the dielectric constant of the medium affects the π resonance to a greater extent than it does the σ one. Other interesting results in this manuscript are connected to homolytic dissociation of diatomic molecules, periodic trends in hydrogen compounds, and polarization of aromatic systems as a consequence of their interaction with electric fields and with diverse ions. PMID:25703955

  14. Impact of Predatory Threat on Fear Extinction in Lewis Rats

    ERIC Educational Resources Information Center

    Goswami, Sonal; Cascardi, Michele; Rodriguez-Sierra, Olga E.; Duvarci, Sevil; Pare, Denis

    2010-01-01

    Humans with post-traumatic stress disorder (PTSD) are deficient at extinguishing conditioned fear responses. A study of identical twins concluded that this extinction deficit does not predate trauma but develops as a result of trauma. The present study tested whether the Lewis rat model of PTSD reproduces these features of the human syndrome.

  15. Lewis Latimer: African American Inventor, Poet and Activist.

    ERIC Educational Resources Information Center

    Judd, Michael

    1998-01-01

    Details a lesson plan that examines the life and career of Lewis Latimer. Latimer, the self-taught son of fugitive slaves, rose to a prominent position in Thomas Edison's Electric Company and pioneered many innovations in the early electric industry. Includes a biographical sketch of Latimer, photographs, and illustrations. (MJP)

  16. Q & A with Ed Tech Leaders: Interview with Brian Lewis

    ERIC Educational Resources Information Center

    Shaughnessy, Michael F.; Fulgham, Susan M.

    2013-01-01

    Brian Lewis, International Society for Technology in Education (ISTE) chief executive officer, is an education advocate and leader specializing in management and governance, policy, corporate communications, branding, and marketing. He provides leadership to ISTE's Washington, DC, and Eugene, Oregon, offices and directs organizational

  17. Lewis Terman: Genetic Study of Genius--Elementary School Students

    ERIC Educational Resources Information Center

    Jolly, Jennifer L.

    2008-01-01

    Although the field of gifted education generally recognizes the foundational work of Lewis Terman, rarely does one stop to examine the details of his longitudinal study and their connection to present-day gifted education. This article reexamines the beginnings of Terman's longitudinal study with a focus on elementary-school-aged children.…

  18. Lewis M. Terman and the "World" of Test Publishing.

    ERIC Educational Resources Information Center

    Minton, Henry L.

    The association between Lewis M. Terman and the World Book Company is traced in order to gain insight about the role of test publishing in the testing movement. The test publisher assumes the position of an intermediary between the test developer and the educational administrator responsible for making decisions about test adoption. Terman began…

  19. "Termanal" Science? The Work of Lewis Terman Revisited.

    ERIC Educational Resources Information Center

    Vialle, Wilma

    1994-01-01

    This article place's Lewis Terman's work in the context of his time and space, in response to criticism of biases against women and certain ethnic groups in his work. The paper concludes that, notwithstanding the unacceptability of his ideas on women and race, Terman's work provides an important foundation for the field of gifted education.…

  20. Bibliography of Lewis Research Center technical publications announced in 1982

    NASA Technical Reports Server (NTRS)

    1983-01-01

    The technical reporting that resulted from the scientific and engineering work performed and managed by the Lewis Research Center in 1982 is described. All the publications were announced in the 1982 issues of STAR (Scientific and Technical Aerospace Reports) and/or IAA (International Aerospace Abstracts). Included are research reports, journal articles, conference presentations, patents and patent applications, and theses.

  1. Bibliography of Lewis Research Center Technical Publications announced in 1991

    NASA Technical Reports Server (NTRS)

    1992-01-01

    This compilation of abstracts describes and indexes the technical reporting that resulted from the scientific engineering work performed and managed by the Lewis Research Center in 1991. All the publications were announced in the 1991 issues of STAR (Scientific and Technical Aerospace Reports) and/or IAA (International Aerospace Abstracts). Included are research reports, journal articles, conference presentations, patents and patent applications, and theses.

  2. Liquid droplet radiator program at the NASA Lewis Research Center

    NASA Technical Reports Server (NTRS)

    Presler, A. F.; Coles, C. E.; Diem-Kirsop, P. S.; White, K. A., III

    1986-01-01

    The NASA Lewis Research Center and the Air Force Rocket Propulsion Laboratory (AFRPL) are jointly engaged in a program for technical assessment of the Liquid Droplet Radiator (LDR) concept as an advanced high performance heat ejection component for future space missions. NASA Lewis has responsibility for the technology needed for the droplet generator, for working fluid qualification, and for investigating the physics of droplets in space; NASA Lewis is also conducting systems/mission analyses for potential LDR applications with candidate space power systems. For the droplet generator technology task, both micro-orifice fabrication techniques and droplet stream formation processes have been experimentally investigated. High quality micro-orifices (to 50 micron diameter) are routinely fabricated with automated equipment. Droplet formation studies have established operating boundaries for the generation of controlled and uniform droplet streams. A test rig is currently being installed for the experimental verification, under simulated space conditions, of droplet radiation heat transfer performance analyses and the determination of the effect radiative emissivity of multiple droplet streams. Initial testing has begun in the NASA Lewis Zero-Gravity Facility for investigating droplet stream behavior in microgravity conditions. This includes the effect of orifice wetting on jet dynamics and droplet formation. Results for both Brayton and Stirling power cycles have identified favorable mass and size comparisons of the LDR with conventional radiator concepts.

  3. Who Needs Lewis Structures to Get VSEPR Geometries?

    ERIC Educational Resources Information Center

    Lindmark, Alan F.

    2010-01-01

    Teaching the VSEPR (valence shell electron-pair repulsion) model can be a tedious process. Traditionally, Lewis structures are drawn and the number of "electron clouds" (groups) around the central atom are counted and related to the standard VSEPR table of possible geometries. A simpler method to deduce the VSEPR structure without first drawing…

  4. False Recognition in Lewy-Body Disease and Frontotemporal Dementia

    ERIC Educational Resources Information Center

    de Boysson, C.; Belleville, S.; Phillips, N. A.; Johns, E. K.; Goupil, D.; Souchay, C.; Bouchard, R.; Chertkow, H.

    2011-01-01

    The primary goal of this study was to evaluate the false recognition phenomenon in persons with frontotemporal dementia (FTD) and those with Lewy-body disease (LBD). Patients with LBD (n=10) or FTD (n=15) and their corresponding controls (n=30) were subjected to the Deese-Roediger-McDermott (DRM) paradigm to induce false recognition. Patients were…

  5. Mach 6 Integrated Systems Tests of Lewis' Hypersonic Tunnel Facility

    NASA Technical Reports Server (NTRS)

    1996-01-01

    A series of 15 integrated systems tests were conducted at the NASA Lewis Research Center's Hypersonic Tunnel Facility (HTF) with test conditions simulating flight up to Mach 6. Facility stagnation conditions up to 3050 R and 1050 psia were obtained with typical test times of 20 to 45 sec.

  6. Beyond "Discovery": Lewis & Clark from an Indigenous Perspective.

    ERIC Educational Resources Information Center

    Littlebear, Richard

    2003-01-01

    Recontextualizes the history of the Lewis and Clark expedition from a Native American perspective. Argues that the success of the expedition hastened killing of American Indians and more firmly entrenched U.S. government policies toward indigenous peoples. Stresses that education, particularly at tribal colleges, is the key to success for…

  7. Statement of Facts for 1975 City-Wide Mock Trial Competitions. Georgia Floyd, Individually and as Parent and Next Friend of Minor, Nelson Floyd v. Fix-It Home Remodeling, Inc. and Sam Baldwin.

    ERIC Educational Resources Information Center

    National Inst. for Citizen Education in the Law, Washington, DC.

    Prepared by the District of Columbia Street Law Project for its annual city-wide mock trial competition, this instructional handout provides material for a civil trial over a claim for damages. During an argument, a friend pushed Nelson Floyd against the railing of a porch. Falling onto the concrete below, Nelson was injured with a broken shin

  8. Statement of Facts for 1975 City-Wide Mock Trial Competitions. Georgia Floyd, Individually and as Parent and Next Friend of Minor, Nelson Floyd v. Fix-It Home Remodeling, Inc. and Sam Baldwin.

    ERIC Educational Resources Information Center

    National Inst. for Citizen Education in the Law, Washington, DC.

    Prepared by the District of Columbia Street Law Project for its annual city-wide mock trial competition, this instructional handout provides material for a civil trial over a claim for damages. During an argument, a friend pushed Nelson Floyd against the railing of a porch. Falling onto the concrete below, Nelson was injured with a broken shin…

  9. Doug Nelson's Contributions to our Understanding of Young Continent-Continent Collisions

    NASA Astrophysics Data System (ADS)

    Klemperer, S. L.; Brown, L. D.; Jones, A. G.

    2002-12-01

    K. Douglas Nelson, Department Chair and Jessie Page Heroy Professor of Earth Sciences at Syracuse University, died suddenly of heart failure on August 17th, 2002, age 49. At the time of his death he was at the heights of an increasingly distinguished career, and had, just prior to his death, agreed to be an invited speaker in this session of the 2002 Fall AGU meeting. Doug began his professional career as a field structural geologist, writing his PhD on the Newfoundland Appalachians, and as a post-doc in South Island, New Zealand. From there he went to Cornell University to join COCORP; he learned to interpret deep seismic reflection data and became hooked on the value of geophysics to the study of large-scale processes in mountain belts. He became one of the proponents of taking the COCORP methodology overseas, to the world's type example of young, continent-continent collisions, the Himalaya. For 10 years from 1992, by now a faculty member at Syracuse, Doug provided operational and intellectual leadership to the INDEPTH program (International Deep Profiling of Tibet and the Himalaya). His talk in this session would undoubtedly have focused on our new understanding of Tibet that resulted in large part from the work that he led and supervised. From the initial conception of INDEPTH as a single reflection profile across Earth's highest mountain range and largest plateau, the program grew through three major stages to encompass a full range of geophysical and geological surveys in a transect that now reaches from the High Himalaya across Tibet. Doug more than anyone was the enthusiastic integrator in the large multi-national group of investigators (from the U.S., China, Canada and Germany), not bound by a single technique, and best able to synthesize the seemingly disparate observations from all the techniques. In recent years he was particularly interested in the combination of magneto-telluric with seismic results to better constrain interpretation of deep geology. Although Doug cannot now write the synthesis of the INDEPTH-3 results from central Tibet, nor lead the final INDEPTH-4 campaign across the northern margin of Tibet that he was already planning, our picture of Tibet, and hence of all continent-continent collisions, has changed and grown far richer as a result of his efforts. Among other things, INDEPTH has traced the top of the Indian plate descending beneath the Himalaya, located the likely limit of penetration of Indian mantle beneath central Tibet, and amassed considerable evidence for widespread melt within the Tibetan crust. The first observation, identification of the suture in an active collision, was a natural outgrowth of Doug's earlier contributions to the geometry of the Applachians and Ouachitas. The second observation directly relates to Doug's interest in the evolution of the deep crust/uppermost mantle in old orogens through delamination. The last observation, that melt is widespread in Tibet, was perhaps the most surprising result of the INDEPTH surveys, and the one that Doug used to greatest effect in his synthesis of deformation and crustal evolution around the Tertiary Indus-Tsangpo suture. Doug's articulate and enthusiastic arguments on the inferred role of low viscosity of the middle crust of the Tibetan plateau have been widely echoed in the latest generation of models by many authors that appeal to the flow of crustal material outwards from the central plateau to its southern and eastern margins. This emphasis on crustal mobility in young continent-continent collisions is already influencing our interpretations of ancient orogens.

  10. Lewis number effects on turbulent premixed flame structure

    SciTech Connect

    Goix, P.J. , 230 - Mont-Saint-Aignan . URA CORIA); Shepherd, I.G. )

    1992-09-01

    The influence of the Lewis number on turbulent flame front geometry is investigated in a premixed turbulent stagnation point flame. A laser tomography technique is used to obtain the flame shape, a fractal analysis of the multiscale flame edges is performed and the distribution of local flame front curvature is determined. Lean H[sub 2]/Air and C[sub 3]H[sub 8]/Air mixtures with similar burning rates were investigated with Lewis numbers of 0.33 and 1.85 respectively. At the conditions studied the laminar H[sub 2]/Air mixture is unstable and a cellular structure is observed. Turbulence in the reactant is generated by a perforated plate and the turbulent length scale (3mm) and intensity (7%) at the nozzle exit are fixed. The equivalence ratio is set so that the burning velocity is the same for all the cases. Results show clearly that the turbulent flame surface area is dependent on the Lewis number. For a Lewis number less than unity surface area production is observed. The shape of the flame front curvature distribution is not found to be very sensitive to the Lewis number. For the H[sub 2]/Air mixture the distribution is skewed toward the positive values indicating the presence of cusps while for the C[sub 3]H[sub 8]/Air mixture the distribution is more symmetrical. In both cases the average curvature is found to be zero, and if the local burning speed varies linearly with curvature, the local positive and negative burning velocity variations due to curvature will balance.

  11. Lewis number effects on turbulent premixed flame structure

    SciTech Connect

    Goix, P.J.; Shepherd, I.G.

    1992-09-01

    The influence of the Lewis number on turbulent flame front geometry is investigated in a premixed turbulent stagnation point flame. A laser tomography technique is used to obtain the flame shape, a fractal analysis of the multiscale flame edges is performed and the distribution of local flame front curvature is determined. Lean H{sub 2}/Air and C{sub 3}H{sub 8}/Air mixtures with similar burning rates were investigated with Lewis numbers of 0.33 and 1.85 respectively. At the conditions studied the laminar H{sub 2}/Air mixture is unstable and a cellular structure is observed. Turbulence in the reactant is generated by a perforated plate and the turbulent length scale (3mm) and intensity (7%) at the nozzle exit are fixed. The equivalence ratio is set so that the burning velocity is the same for all the cases. Results show clearly that the turbulent flame surface area is dependent on the Lewis number. For a Lewis number less than unity surface area production is observed. The shape of the flame front curvature distribution is not found to be very sensitive to the Lewis number. For the H{sub 2}/Air mixture the distribution is skewed toward the positive values indicating the presence of cusps while for the C{sub 3}H{sub 8}/Air mixture the distribution is more symmetrical. In both cases the average curvature is found to be zero, and if the local burning speed varies linearly with curvature, the local positive and negative burning velocity variations due to curvature will balance.

  12. Microgravity noncontact temperature requirements at NASA Lewis Research Center

    NASA Technical Reports Server (NTRS)

    Santoro, G.

    1989-01-01

    NASA Lewis Research Center is currently supporting 66 microgravity science and applications projects. The 66 projects are separated into 23 flight projects and 43 ground-based projects. The part of the NASA Lewis program dealing with flight experiments is divided into six areas: Combustion Science, Materials Science, Fluid Physics, Instrumentation/Equipment, Advanced Technology Development, and Space Station Multi-User Facility studies. The part of the NASA Lewis program dealing with ground-based experiments is coincidentally also divided into six areas: Electronic Materials, Combustion Science, Fluid Dynamics and Transport Phenomena, Metals and Alloys, Glasses and Ceramics, and Physics and Chemistry Experiments. Several purposes exist for ground-based experimenting. Preliminary information is necessary before a decision can be made for flight status, the short low gravity durations available in ground facilities are adequate for a particular study, or extensive ground-based research must be conducted to define and support the microgravity science endeavors contemplated for space. Not all of the 66 microgravity science and application projects at NASA Lewis have temperature requirements, but most do. Since space allocation does not permit a review of all the pertinent projects, a decision was made to restrict the coverage to the science flight projects, flight projects minus the advanced technology development, and multiuser facility efforts. Very little is lost by this decision as the types of temperature requirements for science flight projects can be considered representative of those for the ground-based projects. The noncontact temperature needs at NASA Lewis, as represented by the science flight projects are discussed by describing briefly the experiments themselves, by displaying an illustration of each experimental setup, and by specifying their temperature requisites.

  13. Alpha-synuclein biology in Lewy body diseases

    PubMed Central

    2014-01-01

    ?-Synuclein is an abundantly expressed neuronal protein that is at the center of focus in understanding a group of neurodegenerative disorders called ?-synucleinopathies, which are characterized by the presence of aggregated ?-synuclein intracellularly. Primary ?-synucleinopathies include Parkinsons disease (PD), dementia with Lewy bodies and multiple system atrophy, with ?-synuclein also found secondarily in a number of other diseases, including Alzheimers disease. Understanding how ?-synuclein aggregates form in these different disorders is important for the understanding of its pathogenesis in Lewy body diseases. PD is the most prevalent of the ?-synucleinopathies and much of the initial research on ?-synuclein Lewy body pathology was based on PD but is also relevant to Lewy bodies in other diseases (dementia with Lewy bodies and Alzheimers disease). Polymorphism and mutation studies of SNCA, the gene that encodes ?-synuclein, provide much evidence for a causal link between ?-synuclein and PD. Among the primary ?-synucleinopathies, multiple system atrophy is unique in that ?-synuclein deposition occurs in oligodendrocytes rather than neurons. It is unclear whether ?-synuclein originates from oligodendrocytes or whether it is transmitted somehow from neurons. ?-Synuclein exists as a natively unfolded monomer in the cytosol, but in the presence of lipid membranes it is thought to undergo a conformational change to a folded ?-helical secondary structure that is prone to forming dimers and oligomers. Posttranslational modification of ?-synuclein, such as phosphorylation, ubiquitination and nitration, has been widely implicated in ?-synuclein aggregation process and neurotoxicity. Recent studies using animal and cell models, as well as autopsy studies of patients with neuron transplants, provided compelling evidence for prion-like propagation of ?-synuclein. This observation has implications for therapeutic strategies, and much recent effort is focused on developing antibodies that target extracellular ?-synuclein. PMID:25580161

  14. Impairment of script comprehension in Lewy body spectrum disorders

    PubMed Central

    Gross, Rachel G.; Camp, Emily; McMillan, Corey T.; Dreyfuss, Michael; Gunawardena, Delani; Cook, Philip A.; Morgan, Brianna; Siderowf, Andrew; Hurtig, Howard I.; Stern, Matthew B.; Grossman, Murray

    2014-01-01

    A disabling impairment of higher-order language function can be seen in patients with Lewy body spectrum disorders such as Parkinson's disease (PD), Parkinson's disease dementia (PDD), and dementia with Lewy bodies (DLB). We focus on script comprehension in patients with Lewy body spectrum disorders. While scripts unfold sequentially, constituent events are thought to contain an internal organization. Executive dysfunction in patients with Lewy body spectrum disorders may interfere with comprehension of this internal structure. We examined 42 patients (30 non-demented PD and 12 mildly demented PDD/DLB patients) and 12 healthy seniors. We presented 22 scripts (e.g., “going fishing”), each consisting of six events. Pilot data from young controls provided the basis for organizing associated events into clusters and arranging them hierarchically into scripts. We measured accuracy and latency to judge the order of adjacent events in the same cluster versus adjacent events in different clusters. PDD/DLB patients were less accurate in their ordering judgments than PD patients and controls. Healthy seniors and PD patients were significantly faster to judge correctly the order of highly associated within-cluster event pairs relative to less closely associated different-cluster event pairs, while PDD/DLB patients did not consistently distinguish between these event-pair types. This relative insensitivity to the clustered-hierarchical organization of events was related to executive impairment and to frontal atrophy as measured by volumetric MRI. These findings extend prior work on script processing to patients with Lewy body spectrum disorders and highlight the potential impact of frontal/executive dysfunction on the daily lives of affected patients. PMID:23566691

  15. Alpha-synuclein biology in Lewy body diseases.

    PubMed

    Kim, Woojin Scott; Kågedal, Katarina; Halliday, Glenda M

    2014-01-01

    α-Synuclein is an abundantly expressed neuronal protein that is at the center of focus in understanding a group of neurodegenerative disorders called α-synucleinopathies, which are characterized by the presence of aggregated α-synuclein intracellularly. Primary α-synucleinopathies include Parkinson's disease (PD), dementia with Lewy bodies and multiple system atrophy, with α-synuclein also found secondarily in a number of other diseases, including Alzheimer's disease. Understanding how α-synuclein aggregates form in these different disorders is important for the understanding of its pathogenesis in Lewy body diseases. PD is the most prevalent of the α-synucleinopathies and much of the initial research on α-synuclein Lewy body pathology was based on PD but is also relevant to Lewy bodies in other diseases (dementia with Lewy bodies and Alzheimer's disease). Polymorphism and mutation studies of SNCA, the gene that encodes α-synuclein, provide much evidence for a causal link between α-synuclein and PD. Among the primary α-synucleinopathies, multiple system atrophy is unique in that α-synuclein deposition occurs in oligodendrocytes rather than neurons. It is unclear whether α-synuclein originates from oligodendrocytes or whether it is transmitted somehow from neurons. α-Synuclein exists as a natively unfolded monomer in the cytosol, but in the presence of lipid membranes it is thought to undergo a conformational change to a folded α-helical secondary structure that is prone to forming dimers and oligomers. Posttranslational modification of α-synuclein, such as phosphorylation, ubiquitination and nitration, has been widely implicated in α-synuclein aggregation process and neurotoxicity. Recent studies using animal and cell models, as well as autopsy studies of patients with neuron transplants, provided compelling evidence for prion-like propagation of α-synuclein. This observation has implications for therapeutic strategies, and much recent effort is focused on developing antibodies that target extracellular α-synuclein. PMID:25580161

  16. Diffuse Lewy body disease: correlative neuropathology using anti-ubiquitin immunocytochemistry.

    PubMed Central

    Lennox, G; Lowe, J; Landon, M; Byrne, E J; Mayer, R J; Godwin-Austen, R B

    1989-01-01

    Diffuse Lewy body disease is an important pathological substrate of the common syndrome of parkinsonian dementia. The new technique of anti-ubiquitin immunocytochemistry has been used in a correlative quantitative neuropathological study of fifteen cases of diffuse Lewy body disease, showing that the severity of dementia is related to cortical Lewy body density, whilst subcortical abnormalities make a much less significant contribution. Cortical senile plaques also appear to be part of the pathology of diffuse Lewy body disease and should not therefore be used as an isolated diagnostic criterion for Alzheimer's disease. Diagnostic criteria for diffuse Lewy body disease are discussed. Images PMID:2556498

  17. Imaging and acetylcholinesterase inhibitor response in dementia with Lewy bodies

    PubMed Central

    Graff-Radford, Jonathan; Boeve, Bradley F.; Pedraza, Otto; Ferman, Tanis J.; Przybelski, Scott; Lesnick, Timothy G.; Vemuri, Prashanthi; Senjem, Matthew L.; Smith, Glenn E.; Knopman, David S.; Lowe, Val; Jack, Clifford R.; Petersen, Ronald C.

    2012-01-01

    Acetylcholinesterase inhibitors are commonly used to treat patients with dementia with Lewy bodies. Hippocampal atrophy on magnetic resonance imaging and amyloid-β load on positron emission tomography are associated with the Alzheimer’s disease-related pathology in patients with dementia with Lewy bodies. To date, few studies have investigated imaging markers that predict treatment response in patients with dementia with Lewy bodies. Our objective was to determine whether imaging markers of Alzheimer’s disease-related pathology such as hippocampal volume, brain amyloid-β load on 11C Pittsburgh compound B positron emission tomography predict treatment response to acetylcholinesterase inhibitors in patients with dementia with Lewy bodies. We performed a retrospective analysis on consecutive treatment-naive patients with dementia with Lewy bodies (n = 54) from the Mayo Clinic Alzheimer’s Disease Research Centre who subsequently received acetylcholinesterase inhibitors and underwent magnetic resonance imaging with hippocampal volumetry. Baseline and follow-up assessments were obtained with the Mattis Dementia Rating Scale. Subjects were divided into three groups (reliable improvement, stable or reliable decline) using Dementia Rating Scale reliable change indices determined previously. Associations between hippocampal volumes and treatment response were tested with analysis of covariance adjusting for baseline Dementia Rating Scale, age, gender, magnetic resonance field strength and Dementia Rating Scale interval. Seven subjects underwent 11C Pittsburgh compound B imaging within 12 weeks of magnetic resonance imaging. Global cortical 11C Pittsburgh compound B retention (scaled to cerebellar retention) was calculated in these patients. Using a conservative psychometric method of assessing treatment response, there were 12 patients with reliable decline, 29 stable cases and 13 patients with reliable improvement. The improvers had significantly larger hippocampi than those that declined (P = 0.02) and the stable (P = 0.04) group. An exploratory analysis demonstrated larger grey matter volumes in the temporal and parietal lobes in improvers compared with those who declined (P < 0.05). The two patients who had a positive 11C Pittsburgh compound B positron emission tomography scan declined and those who had a negative 11C Pittsburgh compound B positron emission tomography scan improved or were stable after treatment. Patients with dementia with Lewy bodies who do not have the imaging features of coexistent Alzheimer’s disease-related pathology are more likely to cognitively improve with acetylcholinesterase inhibitor treatment. PMID:22810436

  18. 77 FR 1667 - Nelson S. Galgoul, Av. Edison Passess 909, Rio De Janeiro, R.J., Brazil 20531-070, Respondent...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-11

    ..., the most recent being that of August 12, 2011 (76 FR 50,661 (Aug. 16, 2011)), has continued the... Bureau of Industry and Security Nelson S. Galgoul, Av. Edison Passess 909, Rio De Janeiro, R.J., Brazil... program from the United States to Iran via Brazil, without the required U.S. Government...

  19. The Relationship between College Performance and Basic Skills Assessment Using SAT Scores, the Nelson Denny Reading Test, and Degrees of Reading Power.

    ERIC Educational Resources Information Center

    King, Bruce W.; And Others

    1994-01-01

    Describes a study of basic skills testing in mathematics and reading. Examines the relationships between mathematics course performance and class standing, gender, age, transfer status, and math Scholastic Assessment Tests (SAT) scores; and reading course performance and verbal SAT, Nelson Denny Reading Test, and Degrees of Reading Power Test…

  20. A Statistical Comparison of Selected Performances of Post-Developmental Students and Regular Students Enrolled in Credit Courses at Thomas Nelson Community College.

    ERIC Educational Resources Information Center

    Bragg, Charles D.; And Others

    The Developmental Studies Division of Thomas Nelson Community College provides developmental verbal and mathematics courses to enable inadequately prepared students to obtain the necessary knowledge and basic skills for entry into an associate degree program. A study was conducted to determine if those students who complete the objectives of the…

  1. Does Deafness Spell Disaster? An Analysis of the Written English Levels of Deaf Children in the Nelson Mandela Metropole, South Africa

    ERIC Educational Resources Information Center

    Weir, Carolyn; Aylif, Diana

    2014-01-01

    This article presents the findings of an empirical comparative study in the Nelson Mandela Metropole investigating the difference between the written English of deaf children and the written English of hearing children and makes recommendations on how to improve the writing of deaf children. The psycholinguistic approach was used for the…

  2. Does Deafness Spell Disaster? An Analysis of the Written English Levels of Deaf Children in the Nelson Mandela Metropole, South Africa

    ERIC Educational Resources Information Center

    Weir, Carolyn; Aylif, Diana

    2014-01-01

    This article presents the findings of an empirical comparative study in the Nelson Mandela Metropole investigating the difference between the written English of deaf children and the written English of hearing children and makes recommendations on how to improve the writing of deaf children. The psycholinguistic approach was used for the

  3. A comparative analysis of simulated and observed landslide locations triggered by Hurricane Camille in Nelson County, Virginia

    USGS Publications Warehouse

    Morrissey, M.M.; Wieczorek, G.F.; Morgan, B.A.

    2008-01-01

    In 1969, Nelson County, Virginia received up to 71 cm of rain within 12 h starting at 7 p.m. on August 19. The total rainfall from the storm exceeded the 1000-year return period in the region. Several thousands of landslides were induced by rainfall associated with Hurricane Camille causing fatalities and destroying infrastructure. We apply a distributed transient response model for regional slope stability analysis to shallow landslides. Initiation points of over 3000 debris flows and effects of flooding from this storm are applied to the model. Geotechnical data used in the calculations are published data from samples of colluvium. Results from these calculations are compared with field observations such as landslide trigger location and timing of debris flows to assess how well the model predicts the spatial and temporal distribution. of landslide initiation locations. The model predicts many of the initiation locations in areas where debris flows are observed. Copyright ?? 2007 John Wiley & Sons, Ltd.

  4. The Organization of Narrative Discourse in Lewy Body Spectrum Disorder

    PubMed Central

    Ash, Sharon; McMillan, Corey; Gross, Rachel G.; Cook, Philip; Morgan, Brianna; Boller, Ashley; Dreyfuss, Michael; Siderowf, Andrew; Grossman, Murray

    2011-01-01

    Narrative discourse is an essential component of day-to-day communication, but little is known about narrative in Lewy Body spectrum disorder (LBSD), including Parkinson's disease (PD), Parkinson's disease with dementia (PDD), and dementia with Lewy bodies (DLB). We performed a detailed analysis of a semi-structured speech sample in 32 non-aphasic patients with LBSD, and we related their narrative impairments to gray matter (GM) atrophy using voxel-based morphometry. We found that patients with PDD and DLB have significant difficulty organizing their narrative speech. This was correlated with deficits on measures of executive functioning and speech fluency. Regression analyses associated this deficit with reduced cortical volume in inferior frontal and anterior cingulate regions. These findings are consistent with a model of narrative discourse that includes executive as well as language components and with an impairment of the organizational component of narrative discourse in patients with PDD and DLB. PMID:21689852

  5. Review of Recent Thermophotovoltaic (TPV) Research at Lewis Research Center

    NASA Technical Reports Server (NTRS)

    Chubb, Donald L.; Good, Brian S.; Wilt, David M.; Lowe, Roland A.; Fatemi, Navid S.; Hoffman, Richard H.; Scheiman, David

    1995-01-01

    Thermophotovoltaic (TPV) research at NASA Lewis Research Center that began in the late 1980's is reviewed. This work has been concentrated on low bandgap indium gallium arsenide (InGaAs) PV calls and rare earth - yttrium aluminum garnet (YAG) thin film selective emitters, as well as, TPV system studies. An emittance theory has been developed for the thin film emitters. Experimental spectral emittance results for erbium Er-YAG and holmium Ho-YAG show excellent emittance (greater than or equal to 0.7) within the emission bands. The 0.75 eV InGaAs PV cells fabricated at Lewis have excellent quantum efficiency. An efficiency of 130% has been measured for this cell coupled to an Er-YAG selective emitter and a short pass IR filter.

  6. Review of recent thermophotovoltaic (TPV) research at Lewis Research Center

    NASA Technical Reports Server (NTRS)

    Chubb, Donald L.; Good, Brian S.; Wilt, David M.; Lowe, Roland A.; Fatemi, Navid S.; Hoffman, Richard H.; Scheiman, David

    1996-01-01

    Thermophotovoltaic (TPV) research at NASA Lewis Research Center that began in the late 1980's is reviewed. This work has been concentrated on low bandgap indium gallium arsenide (InGaAs) PV cells and rare earth yttrium aluminum garnet (YAG) thin film selective emitters, as well as, TPV system studies. An emittance theory has been developed for the thin film emitters. Experimental spectral emittance results for erbium Er-YAG and holmium Ho-YAG show excellent emittance (greater than or equal to .7) within the emission bands. The .75 eV InGaAs PV cells fabricated at Lewis have excellent quantum efficiency. An efficiency of 13% has been measured for this cell coupled to an Er-YAG selective emitter and a short pass IR filter.

  7. Engines and innovation: Lewis Laboratory and American propulsion technology

    NASA Technical Reports Server (NTRS)

    Dawson, Virginia Parker

    1991-01-01

    This book is an institutional history of the NASA Lewis Research Center, located in Cleveland, Ohio, from 1940, when Congress authorized funding for a third laboratory for the National Advisory Committee for Aeronautics, through the 1980s. The history of the laboratory is discussed in relation to the development of American propulsion technology, with particular focus on the transition in the 1940s from the use of piston engines in airplanes to jet propulsion and that from air-breathing engines to rocket technology when the National Aeronautics and Space Administration was established in 1958. The personalities and research philosophies of the people who shaped the history of the laboratory are discussed, as is the relationship of Lewis Research Center to the Case Institute of Technology.

  8. Familial Dementia With Lewy Bodies With an Atypical Clinical Presentation

    PubMed Central

    Bonner, Lauren T.; Tsuang, Debby W.; Cherrier, Monique M.; Eugenio, Charisma J.; Du, Jennifer Q.; Steinbart, Ellen J.; Limprasert, Pornprot; La Spada, Albert R.; Seltzer, Benjamin; Bird, Thomas D.; Leverenz, James B.

    2006-01-01

    The authors report a case of a 64-year-old male with Alzheimer’s disease (AD) and dementia with Lewy bodies (DLB) pathology at autopsy who did not manifest the core symptoms of DLB until very late in his clinical course. His initial presentation of early executive and language dysfunction suggested a cortical dementia similar to frontotemporal lobar degeneration (FTLD). Core symptoms of DLB including dementia, hallucination, and parkinsonian symptoms were not apparent until late in the course of his illness. Autopsy revealed both brainstem and cortical Lewy bodies and AD pathology. Family history revealed 7 relatives with a history of dementia including 4 with possible or probable DLB. This case is unique because of the FTLD-like presentation, positive family history of dementia, and autopsy confirmation of DLB. PMID:12641375

  9. Modeling Lewis acidity of transition aluminas by numerical simulations

    SciTech Connect

    Alvarez, L.J.; Blumenfeld, A.L.; Fripiat, J.J.

    1998-01-01

    The bulk and surface features of an alumina particle obtained by molecular-dynamics simulation are used to support the experimental distribution of aluminums with respect to their coordination number obtained by NMR (nuclear magnetic resonance). This information was obtained by using results of various editing procedures of the {sup 27}Al nuclear magnetic resonance, such as the classical one-pulse (1P) magic angle spinning, the cross polarization (CP) from the protons of chemisorbed ammonia and the 1P or CP rotational echo double resonance (REDOR). Because the REDOR technique revealed that the acid Lewis sites are constituted by pairs of four or fivefold coordinated aluminum atoms about 3 {Angstrom} apart, these pairs were counted in the simulated particle. The agreement with experimental surface density of Lewis sites is satisfactory. {copyright} {ital 1998 American Institute of Physics.}

  10. Diffuse Lewy body disease: clinical features in 15 cases.

    PubMed Central

    Byrne, E J; Lennox, G; Lowe, J; Godwin-Austen, R B

    1989-01-01

    Fifteen cases of diffuse Lewy body disease were diagnosed on pathological grounds during a single year in one health district. The range and frequency of clinical features contrast strikingly with previous reports. The majority of cases presented with classical levodopa-responsive Parkinson's disease either alone (6 cases) or with mild cognitive impairment (3 cases); the remaining 6 cases presented with cognitive impairment alone. In time almost all patients developed both dementia and Parkinsonism. The dementia was cortical in type, but unusual in that most (12 cases) showed day-to-day fluctuation in severity at some point in their illness. These findings suggest that diffuse Lewy body disease is not rare, and that it presents in a range of ways from dementia with subsequent Parkinsonism to Parkinson's disease with subsequent dementia. The latter mode of presentation suggests that it should be considered as a significant pathological substrate of dementia in Parkinson's disease. Images PMID:2545827

  11. Bibliography of Lewis Research Center Technical Publications announced in 1979

    NASA Technical Reports Server (NTRS)

    1980-01-01

    This compilation of over 1100 abstracts describes and indexes the technical reporting that resulted from the scientific and engineering work performed and managed by the Lewis Research Center in 1979. All the publications were announced in the 1979 issues of STAR (Scientific and Technical Aerospace Reports) and/or IAA (International Aerospace Abstracts). Research reports, journal articles, conference presentations, patents and patent applications, and theses are included. Subject, author, corporate source, contract number, and report number indexes are provided.

  12. Bibliography of Lewis Research Center technical publications announced in 1985

    NASA Technical Reports Server (NTRS)

    1986-01-01

    This compilation of abstracts describes and indexes the technical reporting that resulted from the scientific and engineering work performed and managed by the Lewis Research Center in 1985. All the publications were announced in the 1985 issues of STAR (Scientific and Technical Aerospace Reports) and/or IAA (International Aerospace Abstracts). Included are research reports, journal articles, conference presentations, patents and patent applications, and theses.

  13. Bibliography of Lewis Research Center technical publications announced in 1986

    NASA Technical Reports Server (NTRS)

    1987-01-01

    This compilation of abstracts describes and indexes the technical reporting that resulted from the scientific and engineering work performed and managed by the Lewis Research Center in 1986. All the publications were announced in the 1986 issues of Scientific and Technical Aerospace Reports (STAR) and/or International Aerospace Abstracts (IAA). Included are research reports, journal articles, conference presentations, patents and patent applications, and theses.

  14. Lewis Structures Technology, 1988. Volume 1: Structural Dynamics

    NASA Technical Reports Server (NTRS)

    1988-01-01

    The specific purpose of the symposium was to familiarize the engineering structures community with the depth and range of research performed by the Structures Division of the Lewis Research Center and its academic and industrial partners. Sessions covered vibration control, fracture mechanics, ceramic component reliability, parallel computing, nondestructive testing, dynamical systems, fatigue and damage, wind turbines, hot section technology, structural mechanics codes, computational methods for dynamics, structural optimization, and applications of structural dynamics.

  15. NASA Lewis' Telescience Support Center Supports Orbiting Microgravity Experiments

    NASA Technical Reports Server (NTRS)

    Hawersaat, Bob W.

    1998-01-01

    The Telescience Support Center (TSC) at the NASA Lewis Research Center was developed to enable Lewis-based science teams and principal investigators to monitor and control experimental and operational payloads onboard the International Space Station. The TSC is a remote operations hub that can interface with other remote facilities, such as universities and industrial laboratories. As a pathfinder for International Space Station telescience operations, the TSC has incrementally developed an operational capability by supporting space shuttle missions. The TSC has evolved into an environment where experimenters and scientists can control and monitor the health and status of their experiments in near real time. Remote operations (or telescience) allow local scientists and their experiment teams to minimize their travel and maintain a local complement of expertise for hardware and software troubleshooting and data analysis. The TSC was designed, developed, and is operated by Lewis' Engineering and Technical Services Directorate and its support contractors, Analex Corporation and White's Information System, Inc. It is managed by Lewis' Microgravity Science Division. The TSC provides operational support in conjunction with the NASA Marshall Space Flight Center and NASA Johnson Space Center. It enables its customers to command, receive, and view telemetry; monitor the science video from their on-orbit experiments; and communicate over mission-support voice loops. Data can be received and routed to experimenter-supplied ground support equipment and/or to the TSC data system for display. Video teleconferencing capability and other video sources, such as NASA TV, are also available. The TSC has a full complement of standard services to aid experimenters in telemetry operations.

  16. Bibliography of Lewis Research Center technical publications announced in 1984

    NASA Technical Reports Server (NTRS)

    1985-01-01

    This compilation of abstracts describes and indexes the technical reporting that resulted from the scientific and engineering work performed and managed by the Lewis Research Center in 1984. All the publications were announced in the 1984 issues of STAR (Scientific and Technical Aerospace Reports) and/or IAA (International Aerospace Abstracts). Included are research reports, journal articles, conference presentations, patents and patent applications, and theses.

  17. Bibliography of Lewis Research Center technical publications announced in 1992

    NASA Technical Reports Server (NTRS)

    1993-01-01

    This compilation of abstracts describes and indexes the technical reporting that resulted from the scientific and engineering work performed and managed by the Lewis Research Center in 1992. All the publications were announced in the 1992 issues of STAR (Scientific and Technical Aerospace Reports) and/or IAA (International Aerospace Abstracts). Included are research reports, journal articles, conference presentations, patents and patent applications, and theses.

  18. Bibliography of Lewis Research Center technical publications announced in 1987

    NASA Technical Reports Server (NTRS)

    1988-01-01

    This compilation of abstracts describes and indexes the technical reporting that resulted from the scientific and engineering work performed and managed by the Lewis Research Center in 1987. All the publications were announced in the 1987 issues of STAR (Scientific and Technical Aerospace Reports) and/or IAA (International Aerospace Abstracts). Included are research reports, journal articles, conference presentations, patents and patent applications, and theses.

  19. Ion Thruster Development at NASA Lewis Research Center

    NASA Technical Reports Server (NTRS)

    Sovey, James S.; Hamley, John A.; Patterson, Michael J.; Rawlin, Vincent K.; Sarver-Verhey, Timothy R.

    1992-01-01

    Recent ion propulsion technology efforts at NASA's Lewis Research Center including development of kW-class xenon ion thrusters, high power xenon and krypton ion thrusters, and power processors are reviewed. Thruster physical characteristics, performance data, life projections, and power processor component technology are summarized. The ion propulsion technology program is structured to address a broad set of mission applications from satellite stationkeeping and repositioning to primary propulsion using solar or nuclear power systems.

  20. Bibliography of Lewis Research Center technical publications announced in 1989

    NASA Technical Reports Server (NTRS)

    1990-01-01

    This compilation of abstracts describes and indexes the technical reporting that resulted from the scientific and engineering work performed and managed by the Lewis Research Center in 1989. All the publications were announced in the 1989 issues of STAR (Scientific and Technical Aerospace Reports) and/or IAA (International Aerospace Abstracts). Included are research reports, journal articles, conference presentations, patents and patent applications, and theses.

  1. Bibliography of Lewis Research Center technical publications announced in 1981

    NASA Technical Reports Server (NTRS)

    1982-01-01

    Technical reporting that resulted from the scientific and engineering work performed and managed by the Lewis Research Center in 1981 are indexed and abstracted. All the publications were announced in the 1981 issues of STAR (Scientific and Technical Aerospace Reports) and/or IAA (International Aerospace Abstracts). Included are research reports, journal articles, conference presentations, patent applications, and theses. A total of 384 technical publications is listed.

  2. Ion thruster development at NASA Lewis Research Center

    SciTech Connect

    Sovey, J.S.; Hamley, J.A.; Patterson, M.J.; Rawlin, V.K. ); Sarver-Verhey, T.R. )

    1993-01-20

    Recent ion propulsion technology efforts at NASA's Lewis Research Center including development of kW-class xenon ion thrusters, high power xenon and krypton ion thrusters, and power processors are reviewed. Thruster physical characteristics, performance data, life projections, and power processor component technology are summarized. The ion propulsion technology program is structured to address a broad set of mission applications from satellite stationkeeping and repositioning to primary propulsion using solar or nuclear power systems.

  3. Structure Of Flame Balls At Low Lewis-numbers (SOFBALL)

    NASA Technical Reports Server (NTRS)

    2004-01-01

    Structure Of Flame Balls At Low Lewis-numbers (SOFBALL) Experiment Mounting Structure (EMS) was used to conduct the SOFBALL experiment on Combustion Module-1. The EMS was inserted into the CM-1 combustion chamber. The chamber was filled with a lean fuel/oxidizer mixture and a spark igniter on the EMS ignited the gas. Very small, weak flames, in the shape of spheres, were formed and studied.

  4. Bibliography of Lewis Research Center technical publications announced in 1990

    NASA Technical Reports Server (NTRS)

    1991-01-01

    This compilation of abstracts describes and indexes the technical reporting that resulted from the scientific and engineering work performed and managed by the Lewis Research Center in 1990. All the publications were announced in the 1990 issues of STAR (Scientific and Technical Aerospace Reports) and/or IAA (International Aerospace Abstracts). Included are research reports, journal articles, conference presentations, patents and patent applications, and theses.

  5. Structure Of Flame Balls At Low Lewis-number (SOFBALL)

    NASA Technical Reports Server (NTRS)

    Ronney, Paul D.

    1995-01-01

    The work has encompassed several topics related to the experimental and theoretical study of combustion limits in premixed flames at microgravity. These topics include (1) flame structure and stability at low Lewis number (which is the basis for the SOFBALL space flight experiment), (2) flame propagation and extinction in cylindrical tubes, and (3) experimental simulation of combustion processes using autocatalytic chemical reactions. Progress on each of these topics is outlined.

  6. Bibliography of Lewis Research Center technical publications announced in 1988

    NASA Technical Reports Server (NTRS)

    1989-01-01

    This bibliography contains abstracts of the technical reports that resulted from the scientific and engineering work performed and managed by the Lewis Research Center in 1988. Subject, author, and corporate source indexes are also included. All the publications were announced in the 1988 issues of STAR (Scientific and Technical Aerospace Reports) and/or IAA (International Aerospace Abstracts). Included are research reports, journal articles, conference presentations, patents and patent applications, and theses.

  7. Update to the NASA Lewis Ice Accretion Code LEWICE

    NASA Technical Reports Server (NTRS)

    Wright, William B.

    1994-01-01

    This report is intended as an update to NASA CR-185129 'User's Manual for the NASA Lewis Ice Accretion Prediction Code (LEWICE).' It describes modifications and improvements made to this code as well as changes to the input and output files, interactive input, and graphics output. The comparison of this code to experimental data is shown to have improved as a result of these modifications.

  8. Bibliography of Lewis Research Center technical publications announced in 1993

    NASA Technical Reports Server (NTRS)

    1994-01-01

    This compilation of abstracts describes and indexes the technical reporting that resulted from the scientific and engineering work performed and managed by the Lewis Research Center in 1993. All the publications were announced in the 1993 issues of STAR (Scientific and Technical Aerospace Reports) and/or IAA (International Aerospace Abstracts). Included are research reports, journal articles, conference presentations, patents and patent applications, and theses.

  9. A Comparison of Lead Abatement Technologies at Lewis Research Center

    NASA Technical Reports Server (NTRS)

    Jeziorowski, Luz Y.; Calla, Joanne

    1997-01-01

    In 1995, Lewis participated in a pilot test of Lead Specifications. The Specifications were sponsored by the Center to Protect Worker's Rights (CPWR). Entitled "Model Specifications for the Protection of Worker's from Lead on Steel Structures", one aspect of this endeavor was to test and compare several lead abatement technologies. The project overview, objectives, team, and requirements as well as abatement methods and materials are outlined.

  10. Chemical Inventory Management at NASA Lewis Research Center

    NASA Technical Reports Server (NTRS)

    Kraft, Shirley S.; Homan, Joseph R.; Bajorek, Michael J.; Dominguez, Manuel B.; Smith, Vanessa L.

    1997-01-01

    The Chemical Management System (CMS) is a client/server application developed with Power Builder and Sybase for the Lewis Research Center (LeRC). Power Builder is a client-server application development tool, Sybase is a Relational Database Management System. The entire LeRC community can access the CMS from any desktop environment. The multiple functions and benefits of the CMS are addressed.

  11. Bibliography of Lewis Research Center technical publications announced in 1977

    NASA Technical Reports Server (NTRS)

    1978-01-01

    This compilation of abstracts describes and indexes over 780 technical reports resulting from the scientific and engineering work performed and managed by the Lewis Research Center in 1977. All the publications were announced in the 1977 issues of STAR (Scientific and Technical Aerospace Reports) and/or IAA (International Aerospace Abstracts). Documents cited include research reports, journal articles, conference presentations, patents and patent applications, and theses.

  12. Lewis' Educational and Research Collaborative Intership Program Grant Closeout Report

    NASA Technical Reports Server (NTRS)

    2003-01-01

    The Lewis' Educational and Research Collaborative Internship Program (LERCIP) is a collaborative undertaking by the Office of Educational Programs at NASA Glenn Research Center at Lewis Field (formerly NASA Lewis Research Center) and the Ohio Aerospace Institute. This program provides 10-week internships and 10 or 12-week fellowships for undergraduate/graduate students and secondary school teachers. Approximately 130 interns are selected to participate in this program each year and begin arriving the second week in May. The internships provide students with introductory professional experiences to complement their academic programs. The interns are given assignments on research and development projects under the personal guidance of NASA professional staff members. Each intern is assigned a NASA mentor who facilitates a research assignment. In addition to the research assignment, the summer program includes a strong educational component that enhances the professional stature of the participants. The educational activities include a research symposium and a variety of workshops, lectures and short courses. An important aspect of the program is that it includes students with diverse social, cultural and economic backgrounds.

  13. Lewis Wolpert discusses development and depression. Interview by Joanne Clough.

    PubMed

    Wolpert, Lewis

    2004-06-01

    Lewis Wolpert is Professor of Biology as Applied to Medicine in the Department of Anatomy and Developmental Biology at University College, London, UK. His research interests focus on the mechanisms that are involved in embryonic development. Lewis originally trained as a civil engineer in South Africa but in 1955 made the move to research in cellular biology at King's College, London. He was made a Fellow of the Royal Society in 1980 and awarded the CBE in 1990. Lewis was also made a Fellow of the Royal Society of Literature in 1999 and has presented science on both radio and TV for several years. He was awarded The Royal Society Michael Faraday Prize in 2000 for his contribution to the public understanding of science, most notably through his Chairmanship of the Committee for the Public Understanding of Science (COPUS; 1993-1998). He is the author of numerous books, including Malignant Sadness: The Anatomy of Depression, Principles of Development, The Unnatural Nature of Science and The Triumph of the Embryo. He also writes a regular column for The Independent. PMID:15149619

  14. Lewis and Clark: Pioneering Meteorological Observers in the American West.

    NASA Astrophysics Data System (ADS)

    Solomon, Susan; Daniel, John S.

    2004-09-01

    The technical achievements of Lewis and Clark have been celebrated in fields ranging from cartography to zoology. As America commemorates the bicentennial of their historic journey across the continent, this paper shows that their meteorological data and personal weather-related observations also are worthy of celebration. While the primary goal of the mission, as described by then-President Jefferson to the Congress, was economic and strategic, both Jefferson and cocaptains Lewis and Clark showed an interest in and capacity for scientific understanding of the meteorology of the then-unknown West. The seasonal evolution and variability of temperatures recorded for the first time by Lewis and Clark on the High Plains can now be shown to be quite close to average, thanks to many decades of collection of modern data by the U.S. Cooperative Observer Network stations along their route. While the diets, lives, and experiences of these early explorers and their men were profoundly different from those of modern Americans, the climate that they documented for the first time with care and accuracy remains familiar to us today.

  15. Beginning Your "Vita Contemplativa"

    ERIC Educational Resources Information Center

    Bartunek, Jean M.

    2007-01-01

    In this article, I describe some of the topics intellectual autobiographies might include, summarize some of what I and others have said in intellectual autobiographies published in "Organization Studies", and invite readers to begin the process of constructing their own. To this end, I suggest some questions and a process readers might use.…

  16. Gilbert Newton Lewis: his influence on physical-organic chemists at Berkeley

    SciTech Connect

    Calvin, M.

    1982-03-01

    A review is presented of the historical contributions of Gilbert N. Lewis to science and a discussion of the influence of Lewis on the research of the members of the physical-organic staff at Berkeley, including Melvin Calvin, during the twenties, thirties and forties. Some specific examples are discussed. Also, the effect of Lewis, his science and administrative concepts in the creation of excellence in a department of chemistry are reviewed.

  17. Cortical and brainstem-type Lewy bodies are immunoreactive for the cyclin-dependent kinase 5.

    PubMed Central

    Brion, J. P.; Couck, A. M.

    1995-01-01

    The immunoreactivity of cortical and brainstem-type Lewy bodies has been investigates with antibodies to the cyclin-dependent kinase 5 (cdk5), to the extracellular regulated kinase 1 (ERK-1), and to the cdc2p34 kinase and with antibodies specific for phosphorylation epitopes typical of paired helical filament-tau (PHF-tau). Both cortical and brainstem-type Lewy bodies in diffuse Lewy body disease and brainstem-type Lewy bodies in Parkinson's disease were found to be immunoreactive for cdk5 but not for cdc2p34 or ERK-1 or with the PHF-tau antibodies. Double immunolabeling showed that cdk5-positive Lewy bodies were also ubiquitin immunoreactive and that cdk5 antibodies labeled as many Lewy bodies as ubiquitin antibodies in adequately fixed tissue. The cdk5 immunoreactivity of Lewy bodies was abolished by preabsorption of the antibody with a cdk5 peptide. The antibodies to cdk5 labeled a single 33-kd species on Western blots of human brain homogenates, with a similar intensity in control, diffuse Lewy body disease, and Alzheimer's disease, and this cdk5 species was found mainly in the particulate fraction of brain homogenates. This observation suggests that cdk5 might be a protein kinase involved in the phosphorylation of a molecular component of Lewy bodies, for example, neurofilament proteins known to be present in these inclusions. Images Figure 1 Figure 2 Figure 3 Figure 4 Figure 5 PMID:7485409

  18. Reduced striatal tyrosine hydroxylase in incidental Lewy body disease

    PubMed Central

    Adler, Charles H.; Sue, Lucia I.; Peirce, Jeffrey B.; Bachalakuri, Jyothi; Dalsing-Hernandez, Jessica E.; Lue, Lih Fen; Caviness, John N.; Connor, Donald J.; Sabbagh, Marwan N.; Walker, Douglas G.

    2009-01-01

    Incidental Lewy body disease (ILBD) is the term used when Lewy bodies are found in the nervous system of subjects without clinically documented parkinsonism or dementia. The prevalence of ILBD in the elderly population has been estimated at between 3.8 and 30%, depending on subject age and anatomical site of sampling. It has been speculated that ILBD represents the preclinical stage of Parkinson’s disease (PD) and/or dementia with Lewy bodies (DLB). Studies of ILBD could potentially identify early diagnostic signs of these disorders. At present, however, it is impossible to know whether ILBD is a precursor to PD or DLB or is just a benign finding of normal aging. We hypothesized that, if ILBD represents an early stage of PD or DLB, it should be associated with depletion of striatal dopaminergic markers. Eleven subjects with ILBD and 27 control subjects were studied. The ILBD subjects ranged in age from 74 to 96 years (mean 86.5) while the control subjects’ age ranged from 75 to 102 years (mean 86.7). Controls and subjects did not differ in terms of age, postmortem interval, gender distribution, medical history conditions, brain weight, neuritic plaque density or Braak neurofibrillary stage. Quantitative ELISA measurement of striatal tyrosine hydroxylase (TH), the principal enzyme for dopamine synthesis, showed a 49.8% (P = 0.01) reduction in ILBD cases, as compared with control cases. The finding suggests that ILBD is not a benign condition but is likely a precursor to PD and/or DLB. PMID:17985144

  19. Additional Improvements to the NASA Lewis Ice Accretion Code LEWICE

    NASA Technical Reports Server (NTRS)

    Wright, William B.; Bidwell, Colin S.

    1995-01-01

    Due to the feedback of the user community, three major features have been added to the NASA Lewis ice accretion code LEWICE. These features include: first, further improvements to the numerics of the code so that more time steps can be run and so that the code is more stable; second, inclusion and refinement of the roughness prediction model described in an earlier paper; third, inclusion of multi-element trajectory and ice accretion capabilities to LEWICE. This paper will describe each of these advancements in full and make comparisons with the experimental data available. Further refinement of these features and inclusion of additional features will be performed as more feedback is received.

  20. Visual cortical excitability in dementia with Lewy bodies

    PubMed Central

    Taylor, John-Paul; Firbank, Michael; O'Brien, John T.

    2016-01-01

    Alterations in the visual system may underlie visual hallucinations in dementia with Lewy bodies (DLB). However, cortical excitability as measured by transcranial magnetic stimulation (TMS) and functional magnetic resonance imaging (fMRI) activation of lower visual areas (V1–3) to visual stimuli appear normal in DLB. We explored the relationship between TMS-determined phosphene threshold and fMRI-related visual activation and found a positive relationship between the two in controls but a negative one in DLB. This double dissociation suggests a loss of inhibition in the visual system in DLB, which may predispose individuals to visual dysfunction and visual hallucinations. PMID:26541688

  1. NASA Lewis advanced IPV nickel-hydrogen technology

    NASA Astrophysics Data System (ADS)

    Smithrick, John J.; Britton, Doris L.

    1993-11-01

    Individual pressure vessel (IPV) nickel-hydrogen technology was advanced at NASA Lewis and under Lewis contracts. Some of the advancements are as follows: to use 26 percent potassium hydroxide electrolyte to improve cycle life and performance, to modify the state of the art cell design to eliminate identified failure modes and further improve cycle life, and to develop a lightweight nickel electrode to reduce battery mass, hence reduce launch and/or increase satellite payload. A breakthrough in the LEO cycle life of individual pressure vessel nickel-hydrogen battery cells was reported. The cycle life of boiler plate cells containing 26 percent KOH electrolyte was about 40,000 accelerated LEO cycles at 80 percent DOD compared to 3,500 cycles for cells containing 31 percent KOH. Results of the boiler plate cell tests have been validated at NWSC, Crane, Indiana. Forty-eight ampere-hour flight cells containing 26 and 31 percent KOH have undergone real time LEO cycle life testing at an 80 percent DOD, 10 C. The three cells containing 26 percent KOH failed on the average at cycle 19,500. The three cells containing 31 percent KOH failed on the average at cycle 6,400. Validation testing of NASA Lewis 125 Ah advanced design IPV nickel-hydrogen flight cells is also being conducted at NWSC, Crane, Indiana under a NASA Lewis contract. This consists of characterization, storage, and cycle life testing. There was no capacity degradation after 52 days of storage with the cells in the discharged state, on open circuit, 0 C, and a hydrogen pressure of 14.5 psia. The catalyzed wall wick cells have been cycled for over 22,694 cycles with no cell failures in the continuing test. All three of the non-catalyzed wall wick cells failed (cycles 9,588; 13,900; and 20,575). Cycle life test results of the Fibrex nickel electrode has demonstrated the feasibility of an improved nickel electrode giving a higher specific energy nickel-hydrogen cell. A nickel-hydrogen boiler plate cell using an 80 mil thick, 90 percent porous Fibrex nickel electrode has been cycled for 10,000 cycles at 40 percent DOD.

  2. Structures Of Flameballs at Low-Lewis number

    NASA Technical Reports Server (NTRS)

    2001-01-01

    The potential for investigating combustion at the limits of flammability, and the implications for spacecraft fire safety, led to the Structures Of Flame Balls At Low Lewis-number (SOFBALL) experiment flown twice aboard the Space Shuttle in 1997. The success there led to reflight on STS-107 Research 1 mission plarned for 2002. This image is a video frame which shows MSL-1 flameballs which are intrinsically dim, thus requiring the use of image intensifiers on video cameras. The principal investigator is Dr. Paul Ronney of the University of Southern California, Los Angeles. Glenn Research in Cleveland, OH, manages the project.

  3. Structures Of Flameballs at Low-Lewis number

    NASA Technical Reports Server (NTRS)

    2001-01-01

    The potential for investigating combustion at the limits of flammability, and the implications for spacecraft fire safety, led to the Structures Of Flame Balls At Low Lewis-number (SOFBALL) experiment flown twice aboard the Space Shuttle in 1997. The success there led to on STS-107 Research 1 mission plarned for 2002. Shown here are video frames captured during the Microgravity Sciences Lab-1 mission in 1997. Flameballs are intrinsically dim, thus requiring the use of image intensifiers on video cameras. The principal investigator is Dr. Paul Ronney of the University of Southern California, Los Angeles. Glenn Research in Cleveland, OH, manages the project.

  4. Structure of Flame Balls at Low Lewis Number (SOFBALL) Video

    NASA Technical Reports Server (NTRS)

    2003-01-01

    The Structure of Flame Balls at Low Lewis (SOFBALL) experiment, was run on Space Shuttle Columbia in 2003 for STS-107. The experiment tested various fuel-oxygen-inert gas mixtures in microgravity to produce flame balls, which are spherical steady flames that reveal combustion processes hidden by the volatile effects of gravity on Earth. In this video, a hydrogen-oxygen-sulfur hexafluoride gas mixture produced nine flame balls, the most ever created at once, one of which lasted 81 minutes making it the longest lasting flame ball ever burned in space.

  5. Lewis Structures Technology, 1988. Volume 2: Structural Mechanics

    NASA Technical Reports Server (NTRS)

    1988-01-01

    Lewis Structures Div. performs and disseminates results of research conducted in support of aerospace engine structures. These results have a wide range of applicability to practitioners of structural engineering mechanics beyond the aerospace arena. The engineering community was familiarized with the depth and range of research performed by the division and its academic and industrial partners. Sessions covered vibration control, fracture mechanics, ceramic component reliability, parallel computing, nondestructive evaluation, constitutive models and experimental capabilities, dynamic systems, fatigue and damage, wind turbines, hot section technology (HOST), aeroelasticity, structural mechanics codes, computational methods for dynamics, structural optimization, and applications of structural dynamics, and structural mechanics computer codes.

  6. Hypersonic engine seal development at NASA Lewis Research Center

    NASA Astrophysics Data System (ADS)

    Steinetz, Bruce M.

    1994-07-01

    NASA Lewis Research Center is developing advanced seal concepts and sealing technology for advanced combined cycle ramjet/scramjet engines being designed for the National Aerospace Plane (NASP). Technologies are being developed for both the dynamic seals that seal the sliding interfaces between articulating engine panels and sidewalls, and for the static seals that seal the heat exchanger to back-up structure interfaces. This viewgraph presentation provides an overview of the candidate engine seal concepts, seal material assessments, and unique test facilities used to assess the leakage and thermal performance of the seal concepts.

  7. Visual cortical excitability in dementia with Lewy bodies.

    PubMed

    Taylor, John-Paul; Firbank, Michael; O'Brien, John T

    2016-05-01

    Alterations in the visual system may underlie visual hallucinations in dementia with Lewy bodies (DLB). However, cortical excitability as measured by transcranial magnetic stimulation (TMS) and functional magnetic resonance imaging (fMRI) activation of lower visual areas (V1-3) to visual stimuli appear normal in DLB. We explored the relationship between TMS-determined phosphene threshold and fMRI-related visual activation and found a positive relationship between the two in controls but a negative one in DLB. This double dissociation suggests a loss of inhibition in the visual system in DLB, which may predispose individuals to visual dysfunction and visual hallucinations. PMID:26541688

  8. Hypersonic engine seal development at NASA Lewis Research Center

    NASA Technical Reports Server (NTRS)

    Steinetz, Bruce M.

    1994-01-01

    NASA Lewis Research Center is developing advanced seal concepts and sealing technology for advanced combined cycle ramjet/scramjet engines being designed for the National Aerospace Plane (NASP). Technologies are being developed for both the dynamic seals that seal the sliding interfaces between articulating engine panels and sidewalls, and for the static seals that seal the heat exchanger to back-up structure interfaces. This viewgraph presentation provides an overview of the candidate engine seal concepts, seal material assessments, and unique test facilities used to assess the leakage and thermal performance of the seal concepts.

  9. Engine component instrumentation development facility at NASA Lewis Research Center

    NASA Technical Reports Server (NTRS)

    Bruckner, Robert J.; Buggele, Alvin E.; Lepicovsky, Jan

    1992-01-01

    The Engine Components Instrumentation Development Facility at NASA Lewis is a unique aeronautics facility dedicated to the development of innovative instrumentation for turbine engine component testing. Containing two separate wind tunnels, the facility is capable of simulating many flow conditions found in most turbine engine components. This facility's broad range of capabilities as well as its versatility provide an excellent location for the development of novel testing techniques. These capabilities thus allow a more efficient use of larger and more complex engine component test facilities.

  10. Hall current effects in the Lewis magnetohydrodynamic generator.

    NASA Technical Reports Server (NTRS)

    Nichols, L. D.; Sovie, R. J.

    1972-01-01

    Data obtained in the Lewis MHD generator are compared with theoretical values calculated using the Dzung (1966) theory. The generator is operated with cesium seeded argon as the working fluid. The gas temperature varies from 1800 to 2100 K, the gas pressure from 19 to 22 N/sq cm, the Mach number from .3 to .5, and the magnetic field strength from .2 to 1.6 tesla. The analysis indicates that there is incomplete seed vaporization and that Hall current shorting paths (through the working fluid to ground at both the entrance and exit of the channel) are limiting generator performance.

  11. Telecommuting (Work-At-Home) at NASA Lewis Research Center

    NASA Technical Reports Server (NTRS)

    Srinidhi, Saragur M.

    1994-01-01

    This report presents a study in evaluating the viability of providing a work-at-home (telecommuting) program for Lewis Research Center's corporate employees using Integrated Services Digital Network (ISDN). Case studies have been presented for a range of applications from casual data access to interactive access. The network performance of telemedia applications were studied against future requirements for such level of remote connectivity. Many of the popular ISDN devices were characterized for network and service functionality. A set of recommendations to develop a telecommuting policy have been proposed.

  12. NASA Lewis advanced IPV nickel-hydrogen technology

    NASA Technical Reports Server (NTRS)

    Smithrick, John J.; Britton, Doris L.

    1993-01-01

    Individual pressure vessel (IPV) nickel-hydrogen technology was advanced at NASA Lewis and under Lewis contracts. Some of the advancements are as follows: to use 26 percent potassium hydroxide electrolyte to improve cycle life and performance, to modify the state of the art cell design to eliminate identified failure modes and further improve cycle life, and to develop a lightweight nickel electrode to reduce battery mass, hence reduce launch and/or increase satellite payload. A breakthrough in the LEO cycle life of individual pressure vessel nickel-hydrogen battery cells was reported. The cycle life of boiler plate cells containing 26 percent KOH electrolyte was about 40,000 accelerated LEO cycles at 80 percent DOD compared to 3,500 cycles for cells containing 31 percent KOH. Results of the boiler plate cell tests have been validated at NWSC, Crane, Indiana. Forty-eight ampere-hour flight cells containing 26 and 31 percent KOH have undergone real time LEO cycle life testing at an 80 percent DOD, 10 C. The three cells containing 26 percent KOH failed on the average at cycle 19,500. The three cells containing 31 percent KOH failed on the average at cycle 6,400. Validation testing of NASA Lewis 125 Ah advanced design IPV nickel-hydrogen flight cells is also being conducted at NWSC, Crane, Indiana under a NASA Lewis contract. This consists of characterization, storage, and cycle life testing. There was no capacity degradation after 52 days of storage with the cells in the discharged state, on open circuit, 0 C, and a hydrogen pressure of 14.5 psia. The catalyzed wall wick cells have been cycled for over 22,694 cycles with no cell failures in the continuing test. All three of the non-catalyzed wall wick cells failed (cycles 9,588; 13,900; and 20,575). Cycle life test results of the Fibrex nickel electrode has demonstrated the feasibility of an improved nickel electrode giving a higher specific energy nickel-hydrogen cell. A nickel-hydrogen boiler plate cell using an 80 mil thick, 90 percent porous Fibrex nickel electrode has been cycled for 10,000 cycles at 40 percent DOD.

  13. Lewis structures technology, 1988. Volume 2: structural mechanics

    SciTech Connect

    Not Available

    1988-05-01

    Lewis Structures Div. performs and disseminates results of research conducted in support of aerospace engine structures. These results have a wide range of applicability to practitioners of structural engineering mechanics beyond the aerospace arena. The engineering community was familiarized with the depth and range of research performed by the division and its academic and industrial partners. Sessions covered vibration control, fracture mechanics, ceramic component reliability, parallel computing, nondestructive evaluation, constitutive models and experimental capabilities, dynamic systems, fatigue and damage, wind turbines, hot section technology (HOST), aeroelasticity, structural mechanics codes, computational methods for dynamics, structural optimization, and applications of structural dynamics, and structural mechanics computer codes.

  14. The NASA Lewis integrated propulsion and flight control simulator

    NASA Technical Reports Server (NTRS)

    Bright, Michelle M.; Simon, Donald L.

    1991-01-01

    A new flight simulation facility has been developed at NASA Lewis to allow integrated propulsion-control and flight-control algorithm development and evaluation in real time. As a preliminary check of the simulator facility and the correct integration of its components, the control design and physics models for an STOVL fighter aircraft model have been demonstrated, with their associated system integration and architecture, pilot vehicle interfaces, and display symbology. The results show that this fixed-based flight simulator can provide real-time feedback and display of both airframe and propulsion variables for validation of integrated systems and testing of control design methodologies and cockpit mechanizations.

  15. Fluctuation spectra in the NASA Lewis bumpy-torus plasma

    NASA Technical Reports Server (NTRS)

    Singh, C. M.; Krawczonek, W. M.; Roth, J. R.; Hong, J. Y.; Powers, E. J.

    1978-01-01

    The electrostatic potential fluctuation spectrum in the NASA Lewis bumpy-torus plasma was studied with capacitive probes in the low pressure (high impedance) mode and in the high pressure (low impedance) mode. Under different operating conditions, the plasma exhibited electrostatic potential fluctuations (1) at a set of discrete frequencies, (2) at a continuum of frequencies, and (3) as incoherent high-frequency turbulence. The frequencies and azimuthal wave numbers were determined from digitally implemented autopower and cross-power spectra. The azimuthal dispersion characteristics of the unstable waves were examined by varying the electrode voltage, the polarity of the voltage, and the neutral background density at a constant magnetic field strength.

  16. NASA Lewis H2-O2 MHD program

    NASA Technical Reports Server (NTRS)

    Smith, M.; Nichols, L. D.; Seikel, G. R.

    1974-01-01

    Performance and power costs of H2-O2 combustion powered steam-MHD central power systems are estimated. Hydrogen gas is assumed to be transmitted by pipe from a remote coal gasifier into the city and converted to electricity in a steam MHD plant having an integral gaseous oxygen plant. These steam MHD systems appear to offer an attractive alternative to both in-city clean fueled conventional steam power plants and to remote coal fired power plants with underground electric transmission into the city. Status and plans are outlined for an experimental evaluation of H2-O2 combustion-driven MHD power generators at NASA Lewis Research Center.

  17. An in vitro investigation to compare the surface roughness of auto glazed, reglazed and chair side polished surfaces of Ivoclar and Vita feldspathic porcelain.

    PubMed

    Sethi, Sumit; Kakade, Dilip; Jambhekar, Shantanu; Jain, Vinay

    2013-12-01

    The change in surface roughness after different surface finishing techniques has attracted the attention of several prosthodontists regarding wear of opposing teeth or restorative material and the strength; plaque retention and appearance of the restoration. However, there is considerable controversy concerning the best methods to achieve the smoothest and strongest porcelain restorations after chair side clinical adjustments. The purpose of this in vitro study was to compare the average surface roughness of a self-glazed surface, a chair side polished surface and a reglazed surface of ceramic. Two feldspathic porcelain, namely VITA VMK94 (Vita Zahnfabrik, Bad Sachingen, Germany) and IVOCLAR CLASSIC (Vivadent AG, FL-9494 Schaan, Liechtenstein) were selected to fabricate 20 specimens of each in the shape of shade guide tabs. A medium-grit diamond rotary cutting instrument was used to remove the glaze layer, and then the surface of half the specimens were re-glazed and the other half were polished using a well-defined sequence of polishing comprising of: Shofu porcelain polishing system, White gloss disc/polishing wheel, Silicone cone with diamond polishing paste and finally with small buff wheel with pumice slurry. The surface roughness (Ra) (μm) of the specimens was evaluated using a profilometer and scanning electron microscope. The data were statistically analyzed by using Student's t test. The results had shown that there is no statistically significant difference both quantitatively and qualitatively, between the surface roughness of reglazed and chair-side polished surface. In addition, both reglazed and chair-side polished surfaces are better than the autoglazed surface. Within all the groups, there is no significant difference between companies. Polishing an adjusted porcelain surface with the suggested sequence of polishing will lead to a finish similar to a re-glazed surface. Therefore chair-side polishing can be a good alternative to reglazing for finishing adjusted porcelain surface. PMID:24431779

  18. True Grit: In Tracking down the Real Story of a Legendary Hero of the Old West, Vaunda Micheaux Nelson also Nabbed the Coretta Scott King Award

    ERIC Educational Resources Information Center

    Fleishhacker, Joy

    2010-01-01

    When Vaunda Micheaux Nelson donned a black Stetson to become the biographer of Deputy U.S. Marshal Bass Reeves, she had no idea that her square-shooting book about an unsung African-American hero of the Old West would win over a posse of fans and earn her the prestigious 2010 Coretta Scott King (CSK) Author Award. "Bad News for Outlaws" (Lerner,…

  19. Geology, hydrology, and water quality of the glacial drift aquifer in the vicinity of the Nelson landfill near Yorkville, Illinois

    USGS Publications Warehouse

    Kay, Robert T.

    2006-01-01

    The geologic and hydrologic characteristics of the sand-and-gravel deposits that compose the glacial drift aquifer in the vicinity of the Nelson Landfill site in Yor-kville, Illinois indicate that the aquifer could be devel-oped as a source of public water supply. The geology of these deposits within the Newark Bedrock Valley is com-plex, however, and a detailed investigation of their water bearing and transmitting properties will be required to successfully locate high-capacity wells. Volatile organic compounds, pesticides, and cyanide were not detected in ground water during this investiga-tion. Metals and nitrogen compounds were not detected at concentrations above their Maximum Contaminant Level. Iron, manganese, and aluminum were detected at concentrations above their Secondary Maximum Con-taminant Level and various constituents were detected at concentrations above background levels downgradi-ent of the landfill. Nitrate and ammonia, presumably derived from agricultural practices, also were detected in samples from locations hydraulically upgradient of the landfill. Oxidation-reduction conditions in the aquifer become more reducing with depth. This change is reflected by a change in the type of nitrogen compound detected and the concentration of dissolved oxygen and iron in the glacial drift aquifer. Concentrations of some of the major ions and metals may be affected by disso-lution of carbonate minerals in the aquifer and perhaps road salts.

  20. Mouse fibroblast L929 cells are less permissive to infection by Nelson Bay orthoreovirus compared to other mammalian cell lines.

    PubMed

    Mok, Lawrence; Wynne, James W; Grimley, Samantha; Shiell, Brian; Green, Diane; Monaghan, Paul; Pallister, Jackie; Bacic, Antony; Michalski, Wojtek P

    2015-07-01

    In recent years, bats have been identified as a natural reservoir for a diverse range of viruses. Nelson Bay orthoreovirus (NBV) was first isolated from the heart blood of a fruit bat (Pteropus poliocephalus) in 1968. While the pathogenesis of NBV remains unknown, other related members of this group have caused acute respiratory disease in humans. Thus the potential for NBV to impact human health appears plausible. Here, to increase our knowledge of NBV, we examined the replication and infectivity of NBV using different mammalian cell lines derived from bat, human, mouse and monkey. All cell lines supported the replication of NBV; however, L929 cells showed a greater than 2 log reduction in virus titre compared with the other cell lines. Furthermore, NBV did not induce major cytopathic effects in the L929 cells, as was observed in other cell lines. Interestingly, the related Pteropine orthoreoviruses, Pulau virus (PulV) and Melaka virus (MelV) were able to replicate to high titres in L929 cells but infection resulted in reduced cytopathic effect. Our study demonstrates a unique virus-host interaction between NBV and L929 cells, where cells effectively control viral infection/replication and limit the formation of syncytia. By elucidating the molecular mechanisms that control this unique relationship, important insights will be made into the biology of this fusogenic virus. PMID:25748429

  1. Possible role of a radiation-induced p53 mutation in a Nelson's syndrome patient with a fatal outcome.

    PubMed

    Pinto, Emilia Modolo; Siqueira, Sheila A C; Cukier, Priscilla; Fragoso, Maria C B V; Lin, Chin Jia; de Mendonca, Berenice Bilharinho

    2011-12-01

    Nelson's syndrome (NS) is characterized by the appearance and/or progression of ACTH-secreting pituitary macroadenomas in patients who had previously undergone bilateral adrenalectomy for the treatment of Cushing's disease. Such corticotroph macroadenomas respond poorly to currently available therapeutic options which include surgery, radiotherapy and chemotherapy. P53 protein accumulation may be detected by immunohistochemistry in pituitary corticotroph adenomas and it has been suggested that it might be causally related to tumor development. Wild type P53 protein plays an important role in the cellular response to ionizing radiation and other DNA damaging agents and is mutated in many human tumors. In this study we report an adult male patient with NS who underwent both transsphenoidal and transcranial pituitary surgeries, conventional and stereotaxic radiotherapy and brachytherapy. Despite of the efforts to control tumor mass and growth, this macroadenoma displayed relentless growth and aggressive behavior. DNA extracted from the first two surgical samples, as well as DNA from peripheral blood leukocytes disclosed normal p53 sequence. DNA extracted from tumor samples obtained at surgeries performed after pituitary irradiation carried a somatic heterozygous mutation, consisting of a deletion of four cytosines between nucleotides 12,144-12,149 in exon 4 of the p53 gene. This frameshift mutation creates a stop codon in exon 4 excluding the expression of a functional protein from the defective allele. These data demonstrate a possible association between the P53 protein loss of function induced by radiotherapy and the aggressive course of the disease in this patient. PMID:19655257

  2. Health assessment for Fort Lewis Logistics Center, Fort Lewis, Washington, Region 10. CERCLIS No. WA7210090067. Final report

    SciTech Connect

    Not Available

    1993-08-06

    Fort Lewis is located in Pierce and Thurston Counties, Washington, on the eastern shore of the southern part of Puget Sound. Groundwater and soil sampling at the Logistics Center has shown volatile organic compounds (VOCs) and heavy metals contamination of the unconfined aquifer beneath and northwest (downgradient) of the Logistics Center. The presence of VOCs in soils at the Logistics Center overlying the unconfined aquifer presents the additional exposure potential if migration of these contaminants through the soil into the aquifer occurs. If the disconnected but functional private wells are used for drinking, bathing, and cooking water, potential exposure could occur through ingestion, dermal absorption, and inhalation.

  3. F119 Nozzle Flaps Tested at Lewis' CE-22 Facility

    NASA Technical Reports Server (NTRS)

    2005-01-01

    The next generation of aircraft fighters requires higher engine performance and enhanced stealth characteristics for air superiority. A Lockheed-Martin/Boeing aircraft with a Pratt & Whitney F119 engine was selected by the Air Force for the next advanced tactical fighter (ATF). As part of this program, the NASA Lewis Research Center entered into a cooperative test program with Pratt & Whitney along with the Air Force to study the performance for various advanced nozzle concepts for the F119 engine. The area of interest was to measure the internal performance (both thrust and flow coefficients) of nozzle flaps redesigned for low observability with minimal performance loss. The experimental program was successfully completed May 1995 in Lewis' CE-22 facility. The models were tested over a wide range of geometric variations and nozzle pressure ratios. Results confirmed that the redesigned nozzle flaps had an insignificant effect on the thrust performance and that the resulting flow patterns should not be a problem in the cooling flow design. The results also agreed well with Pratt & Whitney's computational fluid dynamics analysis. The data obtained from this test were added to the current data base to help validate other performance prediction methodology.

  4. Applied imaging at the NASA Lewis Research Center

    NASA Astrophysics Data System (ADS)

    Slater, Howard A.; Owens, Jay C.

    1993-01-01

    NASA Lewis Research Center in Cleveland, Ohio has just completed the celebration of its 50th anniversary. `During the past 50 years, Lewis helped win World War II, made jet aircraft safer and more efficient, helped Americans land on the Moon ... and engaged in the type of fundamental research that benefits all of us in our daily lives.' As part of the center's long history, the Photographic and Printing Branch has continued to develop and meet the center's research imaging requirements. As imaging systems continue to advance and researchers more clearly understand the power of imaging, investigators are relying more and more on imaging systems to meet program objectives. Today, the Photographic and Printing Branch supports a research community of over 5,000 including advocacy for NASA Headquarters and other government agencies. Complete classified and unclassified imaging services include high- speed image acquisition, technical film and video documentaries, still imaging, and conventional and unconventional photofinishing operations. These are the foundation of the branch's modern support function. This paper provides an overview of the varied applied imaging programs managed by the Photographic and Printing Branch. Emphasis is placed on recent imaging projects including icing research, space experiments, and an on-line image archive.

  5. Effect of Lewis number on wet surface heat exchangers

    NASA Astrophysics Data System (ADS)

    Zafar, Mubashar

    1987-10-01

    A linearized approximate modified analogy theory of wet surface heat exchangers, was developed which predicts the effect of Lewis number more accurately, by introducing modified transfer coefficients, wet bulb depression and wet bulb temperature. A linear approximate model of wet surface heat exchangers is adopted and the equations of the model are rearranged with approximations to two independent sets of equations for modified wet bulb depression and temperature. Each set has been solved previously in published solutions for dry bulb temperature in dry surface heat exchangers, giving modified wet bulb and humidifying efficiencies. The humidifying and wet bulb efficiencies are then calculated using equations derived from the modified wet bulb depression and temperature definitions. An exact finite difference solution, of the basic equations has been used here and compared with the current theory. The comparison showed that for a cross-flow cooling tower and a evaporative cooler, the modified analogy theory is in better agreement for effective Lewis numbers between 0.50 and 3.0.

  6. π-Hole Bonds: Boron and Aluminum Lewis Acid Centers.

    PubMed

    Grabowski, Sławomir J

    2015-05-18

    MP2/aug-cc-pVTZ calculations were performed on complexes of boron and aluminum trihydrides and trihalides with hydrogen cyanide (ZH3 -NCH and ZX3 -NCH; Z=B, Al; X=F, Cl). The complexes are linked through the B⋅⋅⋅N and Al⋅⋅⋅N interactions, which are named as triel bonds and which are classified as π-hole bonds. It was found that they possess numerous characteristics of typical covalent bonds, since they are ruled mainly by processes of the electron charge shift from the Lewis base to the Lewis acid unit. Other configurations of the ZH3 -NCH and ZX3 -NCH complexes linked by the dihydrogen, hydrogen, and halogen bonds were found. However, these interactions are much weaker than the corresponding π-hole bonds. The quantum theory of atoms in molecules and the natural bond orbital approaches were applied to characterize the complexes and interactions analyzed. The crystal structures of triel trihydrides and triel trihalides were also analyzed for comparison with the results of calculations. PMID:25711973

  7. Transmission diagnostic research at NASA Lewis Research Center

    NASA Technical Reports Server (NTRS)

    Zakrajsek, J. J.; Townsend, D. P.; Lewicki, D. G.; Decker, H. J.; Handschuh, R. F.

    1995-01-01

    The NASA Lewis Research Center and the U.S. Army Research Laboratory are involved in a joint research program to advance the technology of aerospace transmissions. Within the last six years, a transmission diagnostics research team was formed to address current and future technology barriers in transmission diagnostics. The diagnostics team conducted a survey to determine critical needs of the diagnostics community. Survey results indicated that experimental verification of gear and bearing fault detection methods and damage magnitude assessment were considered the two most critical research areas of a highly reliable health and usage monitoring system. A plan was implemented by the diagnostics team to address these key research areas, by in-house research and university grants. A variety of transmission fault detection methods were applied to experimentally obtained fatigue data. Failure modes of the fatigue tests include a variety of gear pitting failures, tooth wear, tooth fracture, and bearing spalling failures. Accomplishments to date include verification of several specific gear diagnostic methods, verification of a new pattern recognition method to determine failure, and development of a new method to model gear tooth damage. This paper presents the results of these accomplishments in transmission diagnostics research at NASA Lewis Research Center.

  8. 78 FR 48315 - Drawbridge Operation Regulation; Lewis and Clark River, Astoria, OR

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-08

    ...The Coast Guard has issued a temporary deviation from the operating schedule that governs the Lewis and Clark Bridge which crosses the Lewis and Clark River, mile 1.0, at Astoria, OR. The deviation is necessary to accommodate major roadway maintenance on the bridge. This deviation allows the bridge to remain in the closed position and need not open to maritime...

  9. The First Confirmed Case of Down Syndrome with Dementia with Lewy Bodies

    ERIC Educational Resources Information Center

    Prasher, V. P.; Airuehia, E.; Carey, M.

    2010-01-01

    Dementia with Lewy bodies (DLB) is the second commonest cause of dementia in the general population. Several researches have established an association between Down syndrome (DS) and Alzheimer's disease. Very few studies have however showed such an association between dementia with Lewy bodies and Down syndrome. The occurrence of DLB in persons…

  10. C.S. Lewis as a Forensic Figure in the Religious Agora.

    ERIC Educational Resources Information Center

    Keefe, Carolyn

    This paper considers the British thinker C.S. Lewis as a "forensic figure," defining "forensic" in the sense of public discussion and debate. The paper relates that, long before Lewis emerged as a public persuader, he learned to hold his own in private exchanges with William T. Kirkpatrick, his tutor from 1914-1917, and in letters with his Belfast…

  11. 33 CFR 117.899 - Youngs Bay and Lewis and Clark River.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Youngs Bay and Lewis and Clark River. 117.899 Section 117.899 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY BRIDGES DRAWBRIDGE OPERATION REGULATIONS Specific Requirements Oregon § 117.899 Youngs Bay and Lewis and Clark River. (a) The draw of the...

  12. An Integrated Perspective of Humanism and Supernaturalism for Education: C. S. Lewis's Version of Education

    ERIC Educational Resources Information Center

    Lee, Seung Chun

    2013-01-01

    This paper explores some theoretical reflections on the connection between C. S. Lewis's thoughts on the purpose and process of education and his understanding of supernatural human nature which has been relatively little explored. An introduction about Lewis's career as a college teacher blends into the background of this paper. It is followed by

  13. A Lewis acid-free and phenolate-based magnesium electrolyte for rechargeable magnesium batteries.

    PubMed

    Pan, Baofei; Zhang, Junjie; Huang, Jinhua; Vaughey, John T; Zhang, Lu; Han, Sang-Don; Burrell, Anthony K; Zhang, Zhengcheng; Liao, Chen

    2015-04-11

    A novel Lewis acid-free and phenolate-based magnesium electrolyte has been established. The excellent reversibility and stability of this electrolyte in battery cycling render this novel Lewis acid-free synthetic approach as a highly promising alternative for the development of highly anodically stable magnesium electrolytes for rechargeable magnesium batteries. PMID:25758092

  14. Sentence Processing in Lewy Body Spectrum Disorder: The Role of Working Memory

    ERIC Educational Resources Information Center

    Gross, Rachel G.; McMillan, Corey T.; Chandrasekaran, Keerthi; Dreyfuss, Michael; Ash, Sharon; Avants, Brian; Cook, Philip; Moore, Peachie; Libon, David J.; Siderowf, Andrew; Grossman, Murray

    2012-01-01

    Prior work has related sentence processing to executive deficits in non-demented patients with Parkinson's disease (PD). We extended this investigation to patients with dementia with Lewy bodies (DLB) and PD dementia (PDD) by examining grammatical and working memory components of sentence processing in the full range of patients with Lewy body…

  15. Brain Organochlorines and Lewy Pathology: The Honolulu-Asia Aging Study

    PubMed Central

    Ross, G. Webster; Duda, John E.; Abbott, Robert D.; Pellizzari, Edo; Petrovitch, Helen; Miller, Diane B.; O’Callaghan, James P.; Tanner, Caroline M.; Noorigian, Joseph V.; Masaki, Kamal; Launer, Lenore; White, Lon R.

    2012-01-01

    Background Although organochlorines have been reported more frequently in Parkinson’s disease (PD) brains than controls, the association with brain Lewy pathology is unknown. Honolulu-Asia Aging Study (HAAS) participants, exposed to organochlorines from a variety of sources during mid-life, represent a population well suited to determine the relationship of brain organochlorines with Lewy pathology in decedents from the longitudinal HAAS. Methods Study design included the measurement of 21 organochlorine levels in frozen occipital lobe samples from HAAS decedents. Alpha-synuclein immunostaining performed on 225 brains was used to identify Lewy bodies and Lewy neurites. Results With the potential for spurious associations to appear between Lewy pathology and 17 organochlorine compounds found to be present in at least one brain, initial assessments identified heptachlor epoxide isomer b, methoxychlor, and benzene hexachloride b as being most important. Prevalence of Lewy pathology was 75% (6/8) among brains with any 2 of the 3 compounds, 48.8% (79/162) among those with 1, and 32.7% (18/55) for those with neither (P=0.007 test for trend). While findings persisted after removing cases with PD and dementia with Lewy bodies, and when adjustments were made for age at death, body mass index, pack-years of cigarette smoking, and coffee intake (p=0.013), results were insignificant when correcting for multiple testing. Conclusions While consistent with earlier accounts of an association between organochlorines and clinical PD, associations with Lewy pathology warrant further study. PMID:22976848

  16. 32 CFR Appendix C to Part 552 - Authorized Activities for Fort Lewis Maneuver Area Access

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 3 2011-07-01 2009-07-01 true Authorized Activities for Fort Lewis Maneuver Area Access C Appendix C to Part 552 National Defense Department of Defense (Continued) DEPARTMENT OF.... 552, App. C Appendix C to Part 552—Authorized Activities for Fort Lewis Maneuver Area Access...

  17. 32 CFR Appendix C to Part 552 - Authorized Activities for Fort Lewis Maneuver Area Access

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 3 2010-07-01 2010-07-01 true Authorized Activities for Fort Lewis Maneuver Area Access C Appendix C to Part 552 National Defense Department of Defense (Continued) DEPARTMENT OF.... 552, App. C Appendix C to Part 552—Authorized Activities for Fort Lewis Maneuver Area Access...

  18. LewiSpace: An Exploratory Study with a Machine Learning Model in an Educational Game

    ERIC Educational Resources Information Center

    Ghali, Ramla; Ouellet, Sébastien; Frasson, Claude

    2016-01-01

    The use of educational games as a tool for providing learners with a playful and educational aspect is widespread. In this paper, we present an educational game that we developed to teach a chemistry lesson, namely drawing a Lewis diagram. Our game is a 3D environment known as LewiSpace and aims at balancing between playful and educational…

  19. 75 FR 42460 - Minor Boundary Revision at Lewis and Clark National Historical Park

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-21

    ... National Park Service Minor Boundary Revision at Lewis and Clark National Historical Park AGENCY: National Park Service, Interior. ACTION: Announcement of boundary revision. SUMMARY: Notice is hereby given that, pursuant to 16 U.S.C. 460l- (9)(c)(1), the boundary of Lewis and Clark National Historical Park is...

  20. The Lewis and Clark Expedition. The Constitution Community: Expansion and Reform (1801-1861).

    ERIC Educational Resources Information Center

    Perry, Douglas

    In 1803, President Thomas Jefferson guided a piece of foreign diplomacy through the U.S. Senate, the purchase of Louisiana territory from France. Jefferson chose Meriwether Lewis, his personal secretary, who possessed frontiersman skills to explore the territory. Lewis, in turn, solicited the help of William Clark, whose abilities as a draftsman…

  1. An Integrated Perspective of Humanism and Supernaturalism for Education: C. S. Lewis's Version of Education

    ERIC Educational Resources Information Center

    Lee, Seung Chun

    2013-01-01

    This paper explores some theoretical reflections on the connection between C. S. Lewis's thoughts on the purpose and process of education and his understanding of supernatural human nature which has been relatively little explored. An introduction about Lewis's career as a college teacher blends into the background of this paper. It is followed by…

  2. Adele Parot: Beacon of the Dioclesian Lewis School of Gymnastic Expression in the American West.

    ERIC Educational Resources Information Center

    Barney, Robert Knight

    In the late 1800's, Dioclesian Lewis developed and introduced into the schools his new concept of physical education. Dr. Lewis thought in terms of preventing illness and maintaining bodily strength and health through physical fitness. His "new gymnastics" were based on programs of exercise movements. Employing light equipment suitable for use by…

  3. Unprecedented synergistic effects between weak Lewis and Brønsted acids in Prins cyclization.

    PubMed

    Borkar, Prashant; van de Weghe, Pierre; Reddy, B V Subba; Yadav, J S; Grée, René

    2012-09-25

    Novel synergistic effects between Lewis and Brønsted acids in Prins cyclization are reported. Non-reactive Lewis acids and non-reactive Brønsted acids, which failed to perform Prins cyclization when used alone, have shown remarkable synergistic effects when used in combination to perform the reaction successfully. PMID:22885680

  4. Oral Interpretation of C.S. Lewis'"Narnia Tales": A Refracting of "Pictures."

    ERIC Educational Resources Information Center

    Keefe, Carolyn

    "The Chronicles of Narnia" are a series of seven fairy tales written by C.S. Lewis that have become popular with both children and adults. Lewis points to five aspects of the fairy tale form that made the form suitable for expressing the images he saw. The aspects are: (1) no love interest; (2) no close psychology; (3) severe restraints on

  5. Oral Interpretation of C.S. Lewis'"Narnia Tales": A Refracting of "Pictures."

    ERIC Educational Resources Information Center

    Keefe, Carolyn

    "The Chronicles of Narnia" are a series of seven fairy tales written by C.S. Lewis that have become popular with both children and adults. Lewis points to five aspects of the fairy tale form that made the form suitable for expressing the images he saw. The aspects are: (1) no love interest; (2) no close psychology; (3) severe restraints on…

  6. Enthalpy Costs of Making and Breaking Bonds: A Game of Generating Molecules with Proper Lewis Structures

    ERIC Educational Resources Information Center

    Bell, Peter T.; Adkins, Alyssa D.; Gamble, Rex J.; Schultz, Linda D.

    2009-01-01

    "Enthalpy Costs" is a simple card game created to assist students in developing proper Lewis structure drawing skills. Score keeping is accomplished by tracking the enthalpy changes associated with bond-making and bond-breaking processes during formation of molecules represented by proper Lewis structures. Playing the game requires the student to…

  7. On the Trail of Lewis and Clark: A Journey up the Missouri River.

    ERIC Educational Resources Information Center

    Lourie, Peter

    In 1804, Lewis and Clark and a band of adventurers called the Corps of Discovery embarked on one of the great expeditions in history, the exploration of the newly purchased Louisiana Territory. Much of their time was spent on the Missouri River. Two hundred years later, four friends follow Lewis and Clark's path up the Missouri. Their journey

  8. The First Confirmed Case of Down Syndrome with Dementia with Lewy Bodies

    ERIC Educational Resources Information Center

    Prasher, V. P.; Airuehia, E.; Carey, M.

    2010-01-01

    Dementia with Lewy bodies (DLB) is the second commonest cause of dementia in the general population. Several researches have established an association between Down syndrome (DS) and Alzheimer's disease. Very few studies have however showed such an association between dementia with Lewy bodies and Down syndrome. The occurrence of DLB in persons

  9. Ransom, Religion, and Red Giants: C.S. Lewis and Fred Hoyle

    NASA Astrophysics Data System (ADS)

    Larsen, Kristine

    2010-01-01

    Famed fantasy writer C.S. Lewis (1898-1963) was known to friends as a well-read astronomy aficionado. However, this medieval scholar and Christian apologist embraced a pre-Copernican universe (with its astrological overtones) in his Chronicles of Narnia series and defended the beauty and relevance of the geocentric model in his final academic work, "The Discarded Image". In the "Ransom Trilogy” ("Out of the Silent Planet", "Perelandra", and "That Hideous Strength") philologist Ransom (loosely based on Lewis's close friend J.R.R. Tolkien) travels to Lewis's visions of Mars and Venus, where he interacts with intelligent extraterrestrials, battles with evil scientists, and aids in the continuation of extraterrestrial Christian values. In the final book, Ransom is joined by a handful of colleagues in open warfare against the satanic N.I.C.E. (National Institute for Coordinated Experiments). Geneticist and evolutionary biologist J.B.S. Haldane criticized Lewis for his scientifically inaccurate descriptions of the planets, and his disdain for the scientific establishment. Lewis responded to the criticism in essays of his own. Another of Lewis's favorite scientific targets was atheist Fred Hoyle, whom he openly criticized for anti-Christian statements in Hoyle's BBC radio series. Writer and Lewis friend Dorothy L. Sayers voiced her own criticism of Hoyle. In a letter, Lewis dismissed Hoyle as "not a great philosopher (and none of my scientific colleagues think much of him as a scientist.” Given Lewis's lack of respect for Hoyle, and use of creative license in describing the planets, and the flat-earth, "geocentric” Narnia, it is surprising that Lewis very carefully includes an astronomically correct description of red giants in two novels in the Narnia series ("The Magician's Nephew" and "The Last Battle"). This inclusion is even more curious given that Fred Hoyle is well-known as one of the pioneers in the field of stellar death and the properties of red giants.

  10. Isotopic ages from the Nelson region of South Island New Zealand: crustal structure and definition of the Median Tectonic Zone

    NASA Astrophysics Data System (ADS)

    Kimbrough, D. L.; Tulloch, A. J.; Geary, E.; Coombs, D. S.; Landis, C. A.

    1993-10-01

    Plutonic rocks in the Rotoroa Complex and Drumduan Terrane of South Island, New Zealand yield zircon U/Pb dates of 156 and 142 Ma, respectively, that are interpreted as crystallization ages. Hornblende and biotite 40Ar/ 39Ar dates of 140-130 Ma from the Rotoroa represent either emplacement ages, cooling ages or a metamorphic resetting event. These two units crop out between the Brook Street Terrane and the Separation Point Batholith and lack any clear affinity with tectonostratigraphic terranes of the New Zealand Western or Eastern provinces. The Rotoroa Complex and Drumduan Terrane are interpreted as part of a series of dismembered Mesozoic volcanic-plutonic arc complexes that are sandwiched between terranes of the Western and Eastern provinces, occupying a structural position here referred to as the Median Tectonic Zone (MTZ). Correlative units in Fiordland on the opposite side of the Alpine Fault include the Mackay Intrusives, Darran Complex, Largs Terrane, Lochburn Formation and the Halfway Peak Gabbro. Farther south on Stewart Island the Anglern Complex and Paterson Group are part of the same structural belt. The MTZ is an extension of the original concept of the Median Tectonic Line put forth by Landis and Coombs (1967). Dismemberment and juxtaposition of arc magmatic assemblages in the MTZ with Western and Eastern Province terranes is related to large-scale transcurrent faulting in the Early Cretaceous. Its essential features as a regional tectonostratigraphic terrane were established by ~ 117 Ma as indicated by stitching of the Rotoroa Complex to the Takaka Terrane (Western Province) by the Separation Point Batholith (117-114 Ma). The Echinus Granite yields a 310 Ma U/Pb zircon crystallization age that suggests the granite and associated gneisses are part of the Western Province which may constrain the position of the western margin of the MTZ near Nelson City.

  11. NASA Lewis Propulsion Systems Laboratory Customer Guide Manual

    NASA Technical Reports Server (NTRS)

    Soeder, Ronald H.

    1994-01-01

    This manual describes the Propulsion Systems Laboratory (PSL) at NASA Lewis Research Center. The PSL complex supports two large engine test cells (PSL-3 and PSL-4) that are capable of providing flight simulation to altitudes of 70,000 ft. Facility variables at the engine or test-article inlet, such as pressure, temperature, and Mach number (up to 3.0 for PSL-3 and up to 6.0 planned for PSL-4), are discussed. Support systems such as the heated and cooled combustion air systems; the altitude exhaust system; the hydraulic system; the nitrogen, oxygen, and hydrogen systems; hydrogen burners; rotating screen assemblies; the engine exhaust gas-sampling system; the infrared imaging system; and single- and multiple-axis thrust stands are addressed. Facility safety procedures are also stated.

  12. Lewy body dementia: the impact on patients and caregivers

    PubMed Central

    2014-01-01

    Lewy body dementia (LBD) is the second most common neurodegenerative dementia in older adults, yet there remains a delay in diagnosis that limits healthcare providers’ ability to maximize therapeutic outcomes and enhance patient and caregiver quality of life. The impact of LBD on patients includes limiting the potential exposure to medications that may cause adverse outcomes, and addressing how the disease manifestations, such as autonomic features and behavior, affect quality of life. LBD impact on caregivers has been discussed to a greater degree in the literature, and there is clear evidence of caregiver burden and grief associated with disease manifestations. Other common caregiving concerns, such as access to care, prevention of hospitalization, managing behavior, and reviewing prognosis and nursing home placement, are important to comprehensively address the needs of patients with LBD and their caregivers. PMID:25031635

  13. NASA Lewis Research Center Workshop on Forced Response in Turbomachinery

    NASA Technical Reports Server (NTRS)

    Stefko, George L. (Compiler); Murthy, Durbha V. (Compiler); Morel, Michael (Compiler); Hoyniak, Dan (Compiler); Gauntner, Jim W. (Compiler)

    1994-01-01

    A summary of the NASA Lewis Research Center (LeRC) Workshop on Forced Response in Turbomachinery in August, 1993 is presented. It was sponsored by the following NASA organizations: Structures, Space Propulsion Technology, and Propulsion Systems Divisions of NASA LeRC and the Aeronautics and Advanced Concepts & Technology Offices of NASA Headquarters. In addition, the workshop was held in conjunction with the GUIde (Government/Industry/Universities) Consortium on Forced Response. The workshop was specifically designed to receive suggestions and comments from industry on current research at NASA LeRC in the area of forced vibratory response of turbomachinery blades which includes both computational and experimental approaches. There were eight presentations and a code demonstration. Major areas of research included aeroelastic response, steady and unsteady fluid dynamics, mistuning, and corresponding experimental work.

  14. Disease-modifying therapeutic directions for Lewy-Body dementias.

    PubMed

    Zhang, Qiang; Kim, Young-Cho; Narayanan, Nandakumar S

    2015-01-01

    Dementia with Lewy bodies (DLB) is the second leading cause of dementia following Alzheimer's disease (AD) and accounts for up to 25% of all dementia. DLB is distinct from AD in that it involves extensive neuropsychiatric symptoms as well as motor symptoms, leads to enormous societal costs in terms of direct medical care and is associated with high financial and caregiver costs. Although, there are no disease-modifying therapies for DLB, we review several new therapeutic directions in treating DLB. We discuss progress in strategies to decrease the level of alpha-synuclein, to prevent the cell to cell transmission of misfolded alpha-synuclein, and the potential of brain stimulation in DLB. PMID:26347604

  15. Magnetic-field measurements for the Lewis Research Center cyclotron

    NASA Technical Reports Server (NTRS)

    Fessler, T. E.

    1973-01-01

    The magnetic field of the Lewis Center cyclotron was mapped by using a Hall-effect magnetic-field transducer. Main-field Fourier coefficients were determined on a polar mesh of 40 radii for each of seven levels of main-field coil current. Incremental fields for eight sets of trim coils and two sets of harmonic coils were also determined at four of these main-field levels. A stored-program, digital computer was used to perform the measurements. The process was entirely automatic; all data-taking and data-reduction activities were specified by the computer programs. A new method for temperature compensation of a Hall element was used. This method required no temperature control of the element. Measurements of the Hall voltage and Hall-element resistance were sufficient to correct for temperature effects.

  16. Enhanced Attitude Control Experiment for SSTI Lewis Spacecraft

    NASA Technical Reports Server (NTRS)

    Maghami, Peoman G.

    1997-01-01

    The enhanced attitude control system experiment is a technology demonstration experiment on the NASA's small spacecraft technology initiative program's Lewis spacecraft to evaluate advanced attitude control strategies. The purpose of the enhanced attitude control system experiment is to evaluate the feasibility of designing and implementing robust multi-input/multi-output attitude control strategies for enhanced pointing performance of spacecraft to improve the quality of the measurements of the science instruments. Different control design strategies based on modern and robust control theories are being considered for the enhanced attitude control system experiment. This paper describes the experiment as well as the design and synthesis of a mixed H(sub 2)/H(sub infinity) controller for attitude control. The control synthesis uses a nonlinear programming technique to tune the controller parameters and impose robustness and performance constraints. Simulations are carried out to demonstrate the feasibility of the proposed attitude control design strategy. Introduction

  17. The NASA Lewis Strain Gauge Laboratory: An update

    NASA Technical Reports Server (NTRS)

    Hobart, H. F.

    1986-01-01

    Efforts continue in the development and evaluation of electrical resistance strain gauges of the thin film and small diameter wire type. Results obtained early in 1986 on some Chinese gauges and Kanthal A-1 gauges mounted on a Hastelloy-X substrate are presented. More recent efforts include: (1) the determination of the uncertainty in the ability to establish gauge factor, (2) the evaluation of sputtered gauges that were fabricated at Lewis, (3) an investigation of the efficacy of dual element temperature compensated gauges when using strain gauge alloys having large thermal coefficients of resistance, and (4) an evaluation of the practical methods of stabilizing gauges whose apparent strain is dependent on cooling rate (e.g., FeCrAl gauges).

  18. Structures Of Flameballs at Low-Lewis number

    NASA Technical Reports Server (NTRS)

    2001-01-01

    The potential for investigating combustion at the limits of flammability, and the implications for spacecraft fire safety, led to the Structures Of Flame Balls At Low Lewis-number (SOFBALL) experiment flown twice aboard the Space Shuttle in 1997. The success there led to reflight on STS-107 Research 1 mission plarned for 2002. Theory does not always predict behavior, thus the need for experiments. Three different published chemical reaction models (lines) for hydrogen-airflame balls proved to be quite different from what was observed (dots) during SOFBALL tests in space. The principal investigator is Dr. Paul Ronney of the University of Southern California, Los Angeles. Glenn Research in Cleveland, OH, manages the project.

  19. Materials research and applications at NASA Lewis Research Center

    NASA Technical Reports Server (NTRS)

    Probst, H. B.

    1987-01-01

    The facilities and instruments of the Lewis Research Center specialized for materials research are discussed. The main objectives of the Center are to provide R & D relevant to main propulsion plants and auxiliary power systems for aeronautics, space, and energy conversion applications. The Center is concerned with microstructure-property relations and their effect on processing; intermetallic compounds and high temperature metal matrix composites; ceramics with improved reliability for use in heat engines; polymer matrix composites for aerospace applcations; understanding the high temperature corrosive attack in the hostile environments of aircraft, rockets, and other heat engines; high temperature lubrication and wear; and microgravity materials research. The various types of schemes and techniques, provided by the Center, for analyzing data are described.

  20. The NASA Lewis Research Center SBIR program: An assessment

    NASA Technical Reports Server (NTRS)

    Grimes, Hubert H.; Metzger, Marie E.; Kim, Walter S.

    1993-01-01

    An assessment was made of the NASA Lewis Small Business Innovation Research (SBIR) Program for the years 1983 to 1989. The assessment was based on the study of 99 Phase 1 contracts and 39 Phase 2 contracts. The overall impact of SBIR was found to be very positive, contributing strongly to many NASA programs. In addition, many successful efforts were commercialized benefiting the small business, federal agencies, and the aerospace industry. The program was evaluated in terms of contract quality, innovativeness, comparison to the state-of-the-art, achievement of goals, difficulty, and impact. Program difficulties were also identified, which could suggest possible program improvements. Much of the information gained in this assessment provided a basis for a SBIR data base which will be updated every year. This data base is computerized and will provide an excellent source of information about past SBIR efforts and company capabilities.

  1. Multisystem Lewy body disease and the other parkinsonian disorders.

    PubMed

    Langston, J William; Schüle, Birgitt; Rees, Linda; Nichols, R Jeremy; Barlow, Carrolee

    2015-12-01

    Here we prioritize as multisystem Lewy body disease (MLBD) those genetic forms of Parkinson's disease that point the way toward a mechanistic understanding of the majority of sporadic disease. Pathological diagnosis of genetic subtypes offers the prospect of distinguishing different mechanistic trajectories with a common mutational etiology, differing outcomes from varying allelic bases, and those disease-associated variants that can be used in gene-environment analysis. Clearly delineating parkinsonian disorders into subclasses on the basis of molecular mechanisms with well-characterized outcome expectations is the basis for refining these forms of neurodegeneration as research substrate through the use of cell models derived from affected individuals while ensuring that clinically collected data can be used for therapeutic decisions and research without increasing the noise and confusion engendered by the collection of data against a range of historically defined criteria. PMID:26620112

  2. Lewis acid-assisted detection of nerve agents in water.

    PubMed

    Butala, Rahul R; Creasy, William R; Fry, Roderick A; McKee, Michael L; Atwood, David A

    2015-06-01

    The five-coordinate compound, Salen((t)Bu)Al(Ac), prepared in situ from Salen((t)Bu)AlBr and NH4Ac, forms Lewis acid-base adducts in aqueous solution with the G-type nerve agents, Sarin and Soman, and the VX hydrolysis product, ethylmethylphosphonate (EMPA). The resulting compounds, [Salen((t)Bu)Al(NA)](+)[Ac] (-) (with NA = Sarin, Soman, and EMPA) are sufficiently stable to be identified by ESI-MS. Molecular ion peaks were detected for every compound with little or no fragmentation. The distinctive MS signatures for the [Salen((t)Bu)Al(NA)](+) compounds provide a new technique for identifying nerve agents from aqueous solution. The energetics of the displacement of Ac(-) by the nerve agents to form [Salen((t)Bu)Al(NA)](+)[Ac](-) were determined computationally. PMID:25820753

  3. What are the relations between Lewy body disease and AD?

    PubMed

    McKeith, I G; Ince, P; Jaros, E B; Fairbairn, A; Ballard, C; Grace, J; Morris, C M; Perry, R H

    1998-01-01

    Several hospital based autopsy series indicate dementia with Lewy bodies (DLB) to be the second most common pathological subtype of degenerative dementia in elderly subjects. The majority of DLB cases have high densities of beta amyloid senile plaques, whereas neocortical neurofibrillary tangle density is only slightly increased above age-matched normal control values and over tenfold lower than the average in Alzheimer's disease. The interpretation of this Alzheimer type pathology is problematic, reflecting in part changing views about the neuropathological diagnosis of AD itself. AD is characterised by hyperphosphorylation of the microtubular associated protein tau, and DLB by neurofilament abnormalities including phosphorylation, ubiquitination, proteolysis, and cross-linking of constituent proteins. The two diseases appear therefore to be distinct at an ultrastructural and molecular level, a conclusion which is consistent with the fact that the clinical syndromes associated with DLB and AD are sufficiently differentiated to allow for accurate antemortem diagnosis. PMID:9850919

  4. Lower hybrid emission diagnostics on the NASA Lewis bumpy torus

    NASA Technical Reports Server (NTRS)

    Mallavarpu, R.

    1977-01-01

    The feasibility of using RF emission near the lower hybrid frequency of the NASA Lewis Bumpy Torus plasma for diagnostic purposes is examined. The emission is detected using a spectrum analyzer and a 50 omega miniature coaxial antenna that is sensitive to the polarization of the incoming signal. The frequency shift of the lower hybrid emission peak is monitored as a function of the background pressure, electrode voltage, electrode ring configuration and the strength of the toroidal dc magnetic field. Simultaneous measurements of the average plasma density are made with a polarization diplexing microwave interferometer. Data derived from the experiment are discussed with reference to the following: (1) the strength of the dc magnetic field in the emitting region; (2) comparison of the lower hybrid plasma density with the average plasma density; and (3) validity of the cold plasma lower hybrid resonance formula in the high density operating regime of the bumpy torus plasma.

  5. Transport coefficients for the NASA Lewis Chemical Equilibrium Program

    SciTech Connect

    Svehla, R.A.

    1995-04-01

    The new transport property data that will be used in the NASA Lewis Research Center`s Chemical Equilibrium and Applications Program (CEA) is presented. It complements a previous publication that documented the thermodynamic and transport property data then in use. Sources of the data and a brief description of the method by which the data were obtained are given. Coefficients to calculate the viscosity, thermal conductivity, and binary interactions are given for either one, or usually, two temperature intervals, typically 300 to 1000 K and 1000 to 5000 K. The form of the transport equation is the same as used previously. The number of species was reduced from the previous database. Many species for which the data were estimated were eliminated from the database. Some ionneutral interactions were added.

  6. A Neutral Silicon/Phosphorus Frustrated Lewis Pair.

    PubMed

    Waerder, Benedikt; Pieper, Martin; Körte, Leif A; Kinder, Timo A; Mix, Andreas; Neumann, Beate; Stammler, Hans-Georg; Mitzel, Norbert W

    2015-11-01

    Frustrated Lewis pairs (FLPs) have a great potential for activation of small molecules. Most known FLP systems are based on boron or aluminum atoms as acid functions, few on zinc, and only two on boron-isoelectronic silicenium cation systems. The first FLP system based on a neutral silane, (C2F5)3SiCH2P(tBu)2 (1), was prepared from (C2F5)3SiCl with C2F5 groups of very high electronegativity and LiCH2P(tBu)2. 1 is capable of cleaving hydrogen, and adds CO2 and SO2. Hydrogen splitting was confirmed by H/D scrambling reactions. The structures of 1, its CO2 and SO2 adducts, and a decomposition product with CO2 were elucidated by X-ray diffraction. PMID:26423202

  7. Design of the NASA Lewis 4-Port Wave Rotor Experiment

    NASA Technical Reports Server (NTRS)

    Wilson, Jack

    1997-01-01

    Pressure exchange wave rotors, used in a topping stage, are currently being considered as a possible means of increasing the specific power, and reducing the specific fuel consumption of gas turbine engines. Despite this interest, there is very little information on the performance of a wave rotor operating on the cycle (i.e., set of waves) appropriate for use in a topping stage. One such cycle, which has the advantage of being relatively easy to incorporate into an engine, is the four-port cycle. Consequently, an experiment to measure the performance of a four-port wave rotor for temperature ratios relevant to application as a topping cycle for a gas turbine engine has been designed and built at NASA Lewis. The design of the wave rotor is described, together with the constraints on the experiment.

  8. Disease-modifying therapeutic directions for Lewy-Body dementias

    PubMed Central

    Zhang, Qiang; Kim, Young-Cho; Narayanan, Nandakumar S.

    2015-01-01

    Dementia with Lewy bodies (DLB) is the second leading cause of dementia following Alzheimer's disease (AD) and accounts for up to 25% of all dementia. DLB is distinct from AD in that it involves extensive neuropsychiatric symptoms as well as motor symptoms, leads to enormous societal costs in terms of direct medical care and is associated with high financial and caregiver costs. Although, there are no disease-modifying therapies for DLB, we review several new therapeutic directions in treating DLB. We discuss progress in strategies to decrease the level of alpha-synuclein, to prevent the cell to cell transmission of misfolded alpha-synuclein, and the potential of brain stimulation in DLB. PMID:26347604

  9. Transport Coefficients for the NASA Lewis Chemical Equilibrium Program

    NASA Technical Reports Server (NTRS)

    Svehla, Roger A.

    1995-01-01

    The new transport property data that will be used in the NASA Lewis Research Center's Chemical Equilibrium and Applications Program (CEA) is presented. It complements a previous publication that documented the thermodynamic and transport property data then in use. Sources of the data and a brief description of the method by which the data were obtained are given. Coefficients to calculate the viscosity, thermal conductivity, and binary interactions are given for either one, or usually, two temperature intervals, typically 300 to 1000 K and 1000 to 5000 K. The form of the transport equation is the same as used previously. The number of species was reduced from the previous database. Many species for which the data were estimated were eliminated from the database. Some ionneutral interactions were added.

  10. The NASA Lewis integrated propulsion and flight control simulator

    NASA Technical Reports Server (NTRS)

    Bright, Michelle M.; Simon, Donald L.

    1991-01-01

    A new flight simulation facility was developed at NASA-Lewis. The purpose of this flight simulator is to allow integrated propulsion control and flight control algorithm development and evaluation in real time. As a preliminary check of the simulator facility capabilities and correct integration of its components, the control design and physics models for a short take-off and vertical landing fighter aircraft model were shown, with their associated system integration and architecture, pilot vehicle interfaces, and display symbology. The initial testing and evaluation results show that this fixed based flight simulator can provide real time feedback and display of both airframe and propulsion variables for validation of integrated flight and propulsion control systems. Additionally, through the use of this flight simulator, various control design methodologies and cockpit mechanizations can be tested and evaluated in a real time environment.

  11. Initial results from the NASA Lewis Bumpy Torus experiment

    NASA Technical Reports Server (NTRS)

    Roth, J. R.; Richardson, R. W.; Gerdin, G. A.

    1973-01-01

    Initial results are given for low power operation of the NASA Lewis Bumpy Torus experiment in which a steady-state ion heating method based on a modified Penning discharge is applied to a bumpy torus confinement geometry. The magnet facility consists of 12 superconducting coils capable of 3.0 T each and equally spaced in a toroidal array 1.52 m in major diameter. A 18 cm i.d. anode ring is located at each of the 12 midplanes and is maintained at high positive potentials by a dc power supply. Initial observations indicate electron temperatures from 10 to 150 eV, and ion kinetic temperatures from 200 eV to 1200 eV. Two modes of operation with different radial density profiles can be achieved, depending on the background pressure applied.

  12. Stable Borocyclic Radicals via Frustrated Lewis Pair Hydrogenations.

    PubMed

    Longobardi, Lauren E; Liu, Lei; Grimme, Stefan; Stephan, Douglas W

    2016-03-01

    The synthesis and isolation of stable main group radicals remains an ongoing challenge. Here we report the application of frustrated Lewis pair chemistry to the synthesis of boron-containing radicals. H2 activation with polyaromatic diones and B(C6F5)3 leads to radical formation in good yields. These radicals are robust; they do not decompose on silica gel or react with O2 and are stable at 35 °C under N2 indefinitely. The mechanism of formation is explored experimentally, with support from DFT calculations. EPR and UV/vis spectroscopy as well as cyclic voltammetry data are provided, and the radicals are shown to react with cobaltocenes in one-electron chemical reductions to their corresponding borate anions. PMID:26846796

  13. Rayleigh Scattering Measurements in NASA Lewis Wind Tunnels

    NASA Technical Reports Server (NTRS)

    Seasholtz, Richard

    1996-01-01

    Two applications of Rayleigh scattering for measuring flow parameters in wind tunnels are described. The first is the measurement of one velocity component and static temperature in the vicinity of a 12 % scale advanced short takeoff and vertical landing (ASTOVL) aircraft model in the Lewis 9 ft by 15 ft low speed wing tunnel. The model was equipped with high temperature and high pressure air supplies to simulate lift nozzles and suction systems to simulate engine inlets. The second application is a feasibility study to measure flow properties in a 4 inch by 10 inch supersonic wind tunnel This technique uses an injection seeded, frequency doubled Nd:YAG laser tuned to an absorption band of iodine.

  14. 76 FR 10889 - Record of Decision (ROD) for Grow the Army (GTA) Actions at Fort Lewis and the Yakima Training...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-28

    ... Department of the Army Record of Decision (ROD) for Grow the Army (GTA) Actions at Fort Lewis and the Yakima... Final Environmental Impact Statement (FEIS) for implementing Army GTA decisions at Fort Lewis and YTC... at Fort Lewis to implement GTA stationing decisions, the potential stationing of up to...

  15. Mars Pathfinder Rover-Lewis Research Center Technology Experiments Program

    NASA Technical Reports Server (NTRS)

    Stevenson, Steven M.

    1997-01-01

    An overview of NASA's Mars Pathfinder Program is given and the development and role of three technology experiments from NASA's Lewis Research Center and carried on the Mars Pathfinder rover is described. Two recent missions to Mars were developed and managed by the Jet Propulsion Laboratory, and launched late last year: Mars Global Surveyor in November 1996 and Mars Pathfinder in December 1996. Mars Global Surveyor is an orbiter which will survey the planet with a number of different instruments, and will arrive in September 1997, and Mars Pathfinder which consists of a lander and a small rover, landing on Mars July 4, 1997. These are the first two missions of the Mars Exploration Program consisting of a ten year series of small robotic martian probes to be launched every 26 months. The Pathfinder rover will perform a number of technology and operational experiments which will provide the engineering information necessary to design and operate more complex, scientifically oriented surface missions involving roving vehicles and other machinery operating in the martian environment. Because of its expertise in space power systems and technologies, space mechanisms and tribology, Lewis Research Center was asked by the Jet Propulsion Laboratory, which is heading the Mars Pathfinder Program, to contribute three experiments concerning the effects of the martian environment on surface solar power systems and the abrasive qualities of the Mars surface material. In addition, rover static charging was investigated and a static discharge system of several fine Tungsten points was developed and fixed to the rover. These experiments and current findings are described herein.

  16. Alcohol consumption, Lewis phenotypes, and risk of ischemic heart disease

    SciTech Connect

    Hein, H.O.; Suadicani, P.; Gyntelberg, F. . Epidemiological Research Unit); Sorenson, H. . Dept. of Chemical Immunology); Hein, H.O. . Dept. of Internal Medicine)

    1993-02-13

    The authors have previously found an increased risk of ischemic heart disease (IHD) in men with the Lewis phenotype Le(a[minus]b[minus]) and suggested that the Lewis blood group has a close genetic relation with insulin resistance. The authors have investigated whether any conventional risk factors explain the increased risk in Le(a[minus]b[minus]) men. 3,383 men aged 53-75 years were examined in 1985-86, and morbidity and mortality during the next 4 years were recorded. At baseline, the authors excluded 343 men with a history of myocardial infarction, angina pectoris, intermittent claudication, or stroke. The potential risk factors examined were alcohol consumption, physical activity, tobacco smoking, serum cotinine, serum lipids, body-mass index, blood pressure, prevalence of hypertension and non-insulin-dependent diabetes mellitus, and social class. In 280 (9.6%) men with Le(a[minus]b[minus]), alcohol was the only risk factor significantly associated with risk of IHD. There was a significant inverse dose-effect relation between alcohol consumption and risk; trend tests, with adjustment for age, were significant for fatal IHD (p=0.02), all IHD (p=0.03), and all causes of death (p=0.02). In 2649 (90.4%) men with other phenotypes, there was a limited negative association with alcohol consumption. In Le(a[minus]b[minus]) men, a group genetically at high risk of IHD, alcohol consumption seems to be especially protective. The authors suggest that alcohol consumption may modify insulin resistance in Le(a[minus]b[minus]) men.

  17. Columbia River Fishes of the Lewis and Clark Expedition

    SciTech Connect

    Dauble, Dennis D.

    2007-06-21

    The Lewis and Clark expedition crossed the Continental Divide in 1805 on the way west to the Pacific Ocean. Based on journal entries, members of the expedition probably encountered two species of resident salmonids and four of the six species of anadromous salmonids and steelhead (Family Salmonidae, genus Oncorhynchus). The salmonid species were called common salmon (now known as Chinook salmon O. tshawytscha), red char (sockeye salmon O.nerka) white salmon trout (coho salmon [also known as silver salmon] O. kisutch), salmon trout (steelhead O. mykiss), and spotted trout (cutthroat trout O. clarkii). There was no evidence of the expedition encountering pink salmon O. gorbuscha, chum salmon O. keta, or species of true char Salvelinus spp. Common fishes procured from Indian tribes living along the lower Columbia River included eulachon Thaleichthys pacificus and white sturgeon Acipenser transmontanus. The identity of three additional resident freshwater species is questionable. Available descriptions suggest that what they called mullet were largescale sucker Catastomus macrocheilus, and that chubb were peamouth Mylocheilus caurinus. The third questionable fish, which they called bottlenose, was probably mountain whitefish Prosopium williamsoni, although there is no evidence that the species was observed in the Columbia River drainage. Missing from the species list were more than 20 other fishes known to Sahaptin-speaking people from the mid-Columbia region. More complete documentation of the icthyofauna of the Pacific Northwest region did not occur until the latter half of the 19th century. However, journals from the Lewis and Clark expedition provide the first documentation of Columbia River fishes.

  18. Identification of biomarkers in Lewy-body disorders.

    PubMed

    Warr, L; Walker, Z

    2012-02-01

    Dementia with Lewy bodies (DLB) may account for up to 30% of all dementia cases. The symptoms of DLB can be difficult to disentangle from other dementia subtypes, particularly Alzheimer's disease (AD). AD and DLB pathologies often overlap within individuals. Like DLB, Parkinson's disease dementia (PDD) also shares common features with DLB. Currently, whether an individual is diagnosed with PDD or DLB depends solely on the timing of symptom onset. Early, accurate diagnosis is needed for optimal management and treatment. It is hoped that the development of existing and new Lewy body disorders biomarkers will facilitate more accurate diagnosis. Reduced dopamine transporter levels in DLB as shown with [123I]FP-CIT-SPECT currently appears to be the most reliable and valid biomarker, although other (predominantly imaging-based) methods also appear to have the high sensitivity and specificity required for a good biomarker. This includes (in DLB compared to AD) reduced cardiac 123I-MIBG uptake, occipital hypometabolism on FDG-PET and preservation of medial temporal lobe structures on CT/MRI. Perfusion SPECT, cerebrospinal fluid protein levels (amyloid, tau and α-synuclein), electroencephalography, saccadic eye movement tracking and 11C-PiB amyloid imaging also hold promise as biomarkers in terms of differentiating DLB, AD, PDD and other neurodegenerative disorders, although findings are less consistent. Studies utilising a combination approach in which two or more potential biomarkers are compared seem to provide very good sensitivity and specificity. In general, longitudinal studies, pathological confirmation of diagnosis and the combined approach may hold the most promise for the identification of biomarkers. PMID:22460159

  19. Juvenile cannabinoid treatment induces frontostriatal gliogenesis in Lewis rats.

    PubMed

    Bortolato, Marco; Bini, Valentina; Frau, Roberto; Devoto, Paola; Pardu, Alessandra; Fan, Yijun; Solbrig, Marylou V

    2014-06-01

    Cannabis abuse in adolescence is associated with a broad array of phenotypical consequences, including a higher risk for schizophrenia and other mental disturbances related to dopamine (DA) imbalances. The great variability of these sequelae likely depends on the key influence of diverse genetic vulnerability factors. Inbred rodent strains afford a highly informative tool to study the contribution of genetic determinants to the long-term effects of juvenile cannabinoid exposure. In this study, we analyzed the phenotypical impact of the synthetic cannabinoid agonist WIN 55,212-2 (WIN; 2mg/kg/day from postnatal day 35-48) in adolescent Lewis rats, an inbred strain exhibiting resistance to psychotomimetic effects of environmental manipulations. At the end of this treatment, WIN-injected animals displayed increased survival of new cells (mainly oligodendroglia precursors) in the striatum and prefrontal cortex (PFC), two key terminal fields of DAergic pathways. To test whether these changes may be associated with enduring behavioral alterations, we examined the consequences of adolescent WIN treatment in adulthood (postnatal days 60-70), with respect to DA levels and metabolism as well as multiple behavioral paradigms. Rats injected with WIN exhibited increased turnover, but not levels, of striatal DA. In addition, cannabinoid-treated animals displayed increases in acoustic startle latency and novel-object exploration; however, WIN treatment failed to induce overt deficits of sensorimotor gating and social interaction. These results indicate that, in Lewis rats, juvenile cannabinoid exposure leads to alterations in frontostriatal gliogenesis, as well as select behavioral alterations time-locked to high DAergic metabolism, but not overt schizophrenia-related deficits. PMID:24630433

  20. Lewis pair polymerization by classical and frustrated Lewis pairs: acid, base and monomer scope and polymerization mechanism.

    PubMed

    Zhang, Yuetao; Miyake, Garret M; John, Mallory G; Falivene, Laura; Caporaso, Lucia; Cavallo, Luigi; Chen, Eugene Y-X

    2012-08-14

    Classical and frustrated Lewis pairs (LPs) of the strong Lewis acid (LA) Al(C(6)F(5))(3) with several Lewis base (LB) classes have been found to exhibit exceptional activity in the Lewis pair polymerization (LPP) of conjugated polar alkenes such as methyl methacrylate (MMA) as well as renewable α-methylene-γ-butyrolactone (MBL) and γ-methyl-α-methylene-γ-butyrolactone (γ-MMBL), leading to high molecular weight polymers, often with narrow molecular weight distributions. This study has investigated a large number of LPs, consisting of 11 LAs as well as 10 achiral and 4 chiral LBs, for LPP of 12 monomers of several different types. Although some more common LAs can also be utilized for LPP, Al(C(6)F(5))(3)-based LPs are far more active and effective than other LA-based LPs. On the other hand, several classes of LBs, when paired with Al(C(6)F(5))(3), can render highly active and effective LPP of MMA and γ-MMBL; such LBs include phosphines (e.g., P(t)Bu(3)), chiral chelating diphosphines, N-heterocyclic carbenes (NHCs), and phosphazene superbases (e.g., P(4)-(t)Bu). The P(4)-(t)Bu/Al(C(6)F(5))(3) pair exhibits the highest activity of the LP series, with a remarkably high turn-over frequency of 9.6 × 10(4) h(-1) (0.125 mol% catalyst, 100% MMA conversion in 30 s, M(n) = 2.12 × 10(5) g mol(-1), PDI = 1.34). The polymers produced by LPs at RT are typically atactic (P(γ)MMBL with ∼47% mr) or syndio-rich (PMMA with ∼70-75% rr), but highly syndiotactic PMMA with rr ∼91% can be produced by chiral or achiral LPs at -78 °C. Mechanistic studies have identified and structurally characterized zwitterionic phosphonium and imidazolium enolaluminates as the active species of the current LPP system, which are formed by the reaction of the monomer·Al(C(6)F(5))(3) adduct with P(t)Bu(3) and NHC bases, respectively. Kinetic studies have revealed that the MMA polymerization by the (t)Bu(3)P/Al(C(6)F(5))(3) pair is zero-order in monomer concentration after an initial induction period, and the polymerization is significantly catalyzed by the LA, thus pointing to a bimetallic, activated monomer propagation mechanism. Computational study on the active species formation as well as the chain initiation and propagation events involved in the LPP of MMA with some of the most representative LPs has added our understanding of fundamental steps of LPP. The main difference between NHC and PR(3) bases is in the energetics of zwitterion formation, with the NHC-based zwitterions being remarkably more stable than the PR(3)-based zwitterions. Comparison of the monometallic and bimetallic mechanisms for MMA addition shows a clear preference for the bimetallic mechanism. PMID:22614678

  1. Dementia with Lewy bodies: Definition, diagnosis, and pathogenic relationship to Alzheimer’s disease

    PubMed Central

    Mrak, Robert E; Griffin, W Sue T

    2007-01-01

    Clinical dementia associated with the appearance of Lewy bodies in the cerebral cortex has been recognized for over 40 years. Until the 1990s, however, cortical Lewy body disease was thought to be a rare cause of dementia. At that time, the advent of sensitive and specific immunohistochemical techniques for highlighting these elusive structures led to the recognition of cortical Lewy body disease as a common substrate for clinical dementia. Current diagnostic criteria recognize dementia with Lewy bodies as a clinicopathological entity. Also recognized is the closely related (and perhaps biologically identical) entity of Parkinson’s disease dementia, which differs from dementia with Lewy bodies only in the temporal sequence of appearance of clinical symptoms. The generic term “Lewy body disease” encompasses both entities. There is frequent and extensive overlap, both clinically and pathologically, between dementia with Lewy bodies and Alzheimer’s disease. The two diseases share several genetic and environmental risk factors that have in common increased inflammatory states associated with increased disease risk. Moreover, pathological and experimental work has implicated the involvement of activated microglia and of microglia-derived interleukin-1 in the pathogenesis of the pathognomonic lesions of both diseases. Such neuroinflammatory processes may be the common link driving progression in both diseases and explaining the frequent overlap between the two diseases. PMID:19300591

  2. Highly Lewis Acidic Arylboronate Esters Capable of Colorimetric Turn-On Response.

    PubMed

    Oehlke, Alexander; Auer, Alexander A; Schreiter, Katja; Friebe, Nadine; Spange, Stefan

    2015-12-01

    A series of boronate-π-acceptor compounds containing different types of π bridges (1,4-phenylen or thien-2,5-diyl or furan-2,5-diyl) that link the switchable boronate ester group with the efficient TCF acceptor group (TCF=2-dicyanomethylen-3-cyano-4,5,5-trimethyl-2,5-dihydrofuran) has been synthesized. A TCF chromophore of this type undergoes transition to a donor-π-acceptor compound upon coordination of Lewis bases at the Lewis acidic boron center, which is accompanied by an enhanced intramolecular charge-transfer interaction. The Lewis acid character has been investigated by spectroscopic measurements (UV/Vis, NMR spectroscopies) as well as DFT and ab initio-based calculations. It is shown that the TCF acceptor group and thiophene or furan π-bridges directly bound to the boron atom cooperatively increase the Lewis acidity. UV/Vis titration experiments confirm fluoride binding constants in the range of up to 10(8)  M(-1) in CH2 Cl2 . In addition to the strong boron fluoride binding motif, Lewis interactions also occur with weaker Lewis bases, such as pyridine or aliphatic alcohols. The unique combination of chromophoric and Lewis acidic properties is responsible for the intense colorimetric turn-on response detectable after complex formation. PMID:26489784

  3. Deletion of antigens of the Lewis a/b blood group family in human prostatic carcinoma.

    PubMed Central

    Young, W. W.; Mills, S. E.; Lippert, M. C.; Ahmed, P.; Lau, S. K.

    1988-01-01

    The expression of antigens of the blood group Lewis a/b family were studied in a series of 42 prostatectomy specimens from patients with adenocarcinoma clinically confined to the prostate; 19 of these were later reclassified as pathologic Stage C. Staining of normal or hyperplastic versus neoplastic epithelium was assessed in routinely processed, paraffin-embedded tissue using murine monoclonal antibodies and an avidin-biotin immunoperoxidase technique. Antigens screened and the antibodies used to recognize them were Lewis a (CF4C4), Lewis b and Type 1 H (NS10), monosialosyl Lewis a I (19.9), and disialosyl Lewis a and monosialosyl Lewis a II (FH7). FH7 strongly stained the benign epithelium of all 39 Lewis positive cases, suggesting that the sialyltransferase responsible for synthesis of FH7-reactive determinants is highly active in benign prostatic tissue. When compared to the reactivity of benign epithelium in Lewis positive cases, the staining of the carcinomas was markedly reduced in 18 cases (46%) and absent in 16 cases (41%). This reduction or loss of staining of the malignant epithelium was observed for all antibodies that stained the corresponding benign epithelium of each case. In only five of the cases (13%) was the intensity of staining in the carcinoma equal to that of the surrounding benign epithelium. No cases in this latter group had recurrence of disease, whereas in the other staining groups 25-33% of the cases had recurrences; median follow-up for the entire group was 78 months. No correlation was apparent between Gleason score and the staining pattern with these antigens. In summary, antigens of the Lewis a/b family are deleted in a high percentage of cases of prostatic adenocarcinoma. Images Figure 2 Figure 3 Figure 4 Figure 5 Figure 6 PMID:2454582

  4. Survey on Cosmogenic 26Al in Lewis Cliff Meteorites

    NASA Astrophysics Data System (ADS)

    Welten, K. C.; Alderliesten, C.; Lindner, L.

    1992-07-01

    INTRODUCTION: We have embarked upon a ^26Al gamma-ray survey of meteorites selected from about 2000 samples recently recovered from the Lewis Cliff Ice Fields (84 degrees 18'S/161 degrees 20'E). Due to its 705-ka half-life ^26Al can be used for estimating terrestrial ages and thus contribute to further characterization of Antarctic meteorites in addition to their classification and thermoluminescence (TL) properties. The ^26Al survey is also useful for identifying meteorites with unusual exposure histories, which merit additional measurements of cosmogenic radionuclides (by AMS) and noble gases. In addition, it provides clues on possible pairings. METHOD: Low-level gamma-ray spectroscopy is well suited for ^26Al survey work, since bulk meteorite samples can be measured routinely and nondestructively without any previous sample preparation. The required size of the samples (30-500 g) makes the method relatively independent of depth effects and compositional inhomogeneities. The use of a high-resolution GeLi detector also allows the determination of the natural ^40K activity and thus the K content of the samples, which can be used as an additional pairing criterion for ordinary chondrites. Also ^137Cs, a fall-out surface contamination [1], is simultaneously measured; low values may be characteristic for meteorites recently fallen or released from the ablating ice. For the detector an efficiency calibration curve has been made that adequately accounts for differences in size and shape of the meteorite samples. RESULTS and DISCUSSION: TERRESTRIAL AGES: So far, we have measured over 30 Lewis Cliff equilibrated H and L chondrites, collected from widely differing locations. Normalized to L-chondrite composition, the ^26Al contents range from 27 to 110 dpm/kg with peaks around 43 and 53 dpm/kg. This bimodal ^26Al distribution is reminiscent of that observed for Allan Hills ordinary chondrites [2]. Tentative terrestrial ages, calculated on the basis of ^26Al saturation levels of 56 +- 7 and 60 +- 7 for H and L chondrites, respectively [3], range up to 800 ka with an average of about 290 ka. Altogether this may indicate that the Lewis Cliff blue-ice region is a relatively old meteorite stranding area. This is supported by preliminary conclusions based on ^36Cl, measured in 8 Lewis Cliff meteorites [4]. However, it is likely that some of our terrestrial ages have been overestimated due to (i) lower ^26Al saturation values for meteorites with preatmospheric radii less than 20 cm [3] and (ii) low exposure ages, resulting in initial ^26Al levels below 90-95% of the saturation level. These effects make individual terrestrial age determinations solely based on ^26Al content speculative as long as additional cosmogenic nuclide data are lacking. Dramatic changes in the overall picture are not expected, because (i) we have measured relatively large samples with an average recovered weight of about 500 g (one 11-kg sample excluded) and (ii) anomalously low exposure ages occur in about only 5% of the cases [5,6]. Possible correlations between terrestrial age and place of find will be discussed. UNUSUAL EXPOSURE HISTORIES: We excluded samples with extremely low NTL (<1 krad) from the above discussion, because these may have been exposed to high SCR-fluxes due to smallperihelia orbits (<0.7 A.U.) [7]. This hypothesis is supported by LEW 87169 and 87143, which have extremely low NTL-values in combination with high ^26Al contents. PAIRING CRITERIA: In order to impose additional constraints on pairing possibilities we critically used--besides classification, location of find and TL-properties--the cosmogenic ^26Al and also the natural ^40K content of ordinary chondrites. As an example we will show that the 15 measured Lewis Cliff L6 chondrites are representing at least 10 separate falls. Acknowledgements. This work was performed with financial support from the "Nederlandse Organisatie voor Wetenschappelijk Onderzoek" (NWO). References: 1. Komura K. et al. (1982) Mem. NIPR Spec. Issue 25, 178-187; 2. Evans J.C. and Reeves J.H. (1987) EPSL 82, 223-230; 3. Vogt S. (1990) LPI Tech. Rpt. 90-05, 112-118; 4. Nishizumi K. et al. (1991) Meteoritics 26 (abs.), 380; 5. Graf Th. and Marti K. (1990) Lunar Planet. Sci. XXI, 431-432; 6. Schultz L., Weber H.W. and Begemann F. (1991) GCA 55, 59-66; 7. Benoit P.H. et al. (1990) Ant. J. of the U.S. 25 (Rev.), 47-49.

  5. Plans and status of the NASA-Lewis Research Center wind energy project

    NASA Technical Reports Server (NTRS)

    Thomas, R.; Puthoff, R.; Savino, J.; Johnson, W.

    1975-01-01

    This report describes that portion of the national five-year wind energy program that is being managed by the NASA-Lewis Research Center for the ERDA. The Lewis Research Center's Wind Power Office, its organization and plans and status are briefly described. The three major elements of the wind energy project at Lewis are the experimental 100 kW wind-turbine generator; the first generation industry-built and user-operated wind turbine generators; and the supporting research and technology tasks which are each briefly described.

  6. Activation of Carbonyl-Containing Molecules with Solid Lewis Acids in Aqueous Media

    SciTech Connect

    Román-Leshkov, Yuriy; Davis, Mark E.

    2011-09-28

    Current interest in reacting carbonyl-containing molecules in aqueous media is primarily due to the growing emphasis on conversion of biomass to fuels and chemicals. Recently, solid Lewis acids have been shown to perform catalytic reactions with carbonyl-containing molecules such as sugars in aqueous media. Here, catalysis mediated by Lewis acids is briefly discussed, Lewis acid solids that perform catalysis in aqueous media are then described, and the review is concluded with a few comments on the outlook for the future.

  7. Synthesis and reactivity of electron poor allenes: formation of completely organic frustrated Lewis pairs.

    PubMed

    Palomas, David; Holle, Sigrid; Inés, Blanca; Bruns, Hans; Goddard, Richard; Alcarazo, Manuel

    2012-08-14

    The synthesis of several electron poor allenes bearing electron withdrawing substituents is described and their use as Lewis acids in the field of frustrated Lewis pair (FLP) chemistry reported. At room temperature the combination of N-heterocyclic carbenes (NHC) with the allenes under study invariably afforded the corresponding Lewis adducts; however, at -78 °C this reaction is in most of the cases inhibited and kinetically induced organic FLPs are formed. Under these conditions the activation of S-S bonds in disulfides has been achieved in excellent yields. PMID:22526755

  8. p-hacking by post hoc selection with multiple opportunities: Detectability by skewness test?: Comment on Simonsohn, Nelson, and Simmons (2014).

    PubMed

    Ulrich, Rolf; Miller, Jeff

    2015-12-01

    Simonsohn, Nelson, and Simmons (2014) have suggested a novel test to detect p-hacking in research, that is, when researchers report excessive rates of "significant effects" that are truly false positives. Although this test is very useful for identifying true effects in some cases, it fails to identify false positives in several situations when researchers conduct multiple statistical tests (e.g., reporting the most significant result). In these cases, p-curves are right-skewed, thereby mimicking the existence of real effects even if no effect is actually present. PMID:26595841

  9. Measuring Health: Related Quality of Life in Hemodialysis Patients. Psychometric Properties of the Missoula-VITAS Quality of Life Index (MVQOLI-15) in Greece

    PubMed Central

    Theofilou, Paraskevi; Aroni, Adamantia; Ralli, Maria; Gouzou, Maria; Zyga, Sophia

    2013-01-01

    Different measuring tools have been used to understand the outcomes of end-stage renal disease (ESRD) therapies. However, survival, cost-effectiveness and quality of life (QOL) are the main parameters to evaluate treatment of ESRD. The current study meant to assess the psychometric properties (reliability and validity) of the Missoula-VITAS Quality of Life Index (MVQOLI-15) translation to Greek in patients undergoing hemodialysis (HD). A total sample of 79 HD patients voluntarily participated in this pilot study. Domain analysis of MVQOLI-15-Greek was conducted based on the collected data at initial assessment. The reliability properties of the instrument were tested using the following measures; internal consistency, repeatability, test-retest reliability and convergent validity. Domain analysis demonstrated that all domains of the questionnaire had good variability. MVQOLI-15-Greek internal consistency was satisfactory with an overall Cronbach’s a at 0.74. Pearson’s r and intraclass correlation coefficient revealed strong correlations (ranging from 0.91 to 0.98) between initial assessment and re-assessment. MVQOLI-15-Greek convergent validity analysis indicated that the domains were strongly related to the same construct. The findings of the study indicate that the Greek version of MVQOLI-15 provided satisfactory psychometric properties supporting its use within pathological populations and in the context of national QOL measurement.

  10. Uptake and Effects of the e-Vita Personal Health Record with Self-Management Support and Coaching, for Type 2 Diabetes Patients Treated in Primary Care.

    PubMed

    van Vugt, M; de Wit, M; Sieverink, F; Roelofsen, Y; Hendriks, S H; Bilo, H J G; Snoek, F J

    2016-01-01

    We studied the use, uptake, and effects of e-Vita, a personal health record, with self-management support and personalized asynchronized coaching, for type 2 diabetes patients treated in primary care. Patients were invited by their practice nurse to join the study aimed at testing use and effects of a personal health record. Patients were followed up for 6 months. Uptake and usage were monitored using log data. Outcomes were self-reported diabetes self-care, diabetes-related distress, and emotional wellbeing. Patients' health status was collected from their medical chart. 132 patients agreed to participate in the study of which less than half (46.1%) did not return to the personal health record after 1st login. Only 5 patients used the self-management support program within the personal health record, 3 of whom asked a coach for feedback. Low use of the personal health record was registered. No statistical significant differences on any of the outcome measures were found between baseline and 6 month follow-up. This study showed minimal impact of implementing a personal health record including self-management support in primary diabetes care. Successful adoption of web-based platforms, as ongoing patient centered care, is hard to achieve without additional strategies aimed at enhancing patient motivation and engaging professionals. PMID:26955640

  11. Pathways of nitrogen assimilation in cowpea nodules studied using /sup 15/N/sub 2/ and allopurinol. [Vigna unguiculata L. Walp. cv Vita

    SciTech Connect

    Atkins, C.A.; Storer, P.J.; Pate, J.S.

    1988-01-01

    In the presence of 0.5 millimolar allopurinol (4-hydroxypyrazolo (3,4-d)pyrimidine), an inhibitor of NAD:xanthine oxidoreductase (EC 1.2.3.2), intact attached nodules of cowpea (vigna unguiculata L. Walp. cv Vita 3) formed (/sup 15/N)xanthine from /sup 15/N/sub 2/ at rates equivalent to those of ureide synthesis, confirming the direct assimilation of fixed nitrogen into purines. Xanthine accumulated in nodules and was exported in increasing amounts in xylem of allopurinol-treated plants. Other intermediates of purine oxidation, de novo purine synthesis, and ammonia assimilation did not increase and, over the time course of experiments (4 hours), allopurinol had no effect on nitrogenase (EC 1.87.99.2) activity. Negligible /sup 15/N -labeling of asparagine from /sup 15/N/sub 2/ was observed, suggesting that the significant pool (up to 14 micromoles per gram of nodule fresh weight) of this amide in cowpea nodules was not formed directly from fixation but may have accumulated as a consequence of phloem delivery.

  12. Uptake and Effects of the e-Vita Personal Health Record with Self-Management Support and Coaching, for Type 2 Diabetes Patients Treated in Primary Care

    PubMed Central

    van Vugt, M.; de Wit, M.; Sieverink, F.; Roelofsen, Y.; Hendriks, S. H.; Bilo, H. J. G.; Snoek, F. J.

    2016-01-01

    We studied the use, uptake, and effects of e-Vita, a personal health record, with self-management support and personalized asynchronized coaching, for type 2 diabetes patients treated in primary care. Patients were invited by their practice nurse to join the study aimed at testing use and effects of a personal health record. Patients were followed up for 6 months. Uptake and usage were monitored using log data. Outcomes were self-reported diabetes self-care, diabetes-related distress, and emotional wellbeing. Patients' health status was collected from their medical chart. 132 patients agreed to participate in the study of which less than half (46.1%) did not return to the personal health record after 1st login. Only 5 patients used the self-management support program within the personal health record, 3 of whom asked a coach for feedback. Low use of the personal health record was registered. No statistical significant differences on any of the outcome measures were found between baseline and 6 month follow-up. This study showed minimal impact of implementing a personal health record including self-management support in primary diabetes care. Successful adoption of web-based platforms, as ongoing patient centered care, is hard to achieve without additional strategies aimed at enhancing patient motivation and engaging professionals. PMID:26955640

  13. Menaquinone-7 Supplementation to Reduce Vascular Calcification in Patients with Coronary Artery Disease: Rationale and Study Protocol (VitaK-CAC Trial).

    PubMed

    Vossen, Liv M; Schurgers, Leon J; van Varik, Bernard J; Kietselaer, Bas L J H; Vermeer, Cees; Meeder, Johannes G; Rahel, Braim M; van Cauteren, Yvonne J M; Hoffland, Ge A; Rennenberg, Roger J M W; Reesink, Koen D; de Leeuw, Peter W; Kroon, Abraham A

    2015-11-01

    Coronary artery calcification (CAC) develops early in the pathogenesis of atherosclerosis and is a strong and independent predictor of cardiovascular disease (CVD). Arterial calcification is caused by an imbalance in calcification regulatory mechanisms. An important inhibitor of calcification is vitamin K-dependent matrix Gla protein (MGP). Both preclinical and clinical studies have shown that inhibition of the vitamin K-cycle by vitamin K antagonists (VKA) results in elevated uncarboxylated MGP (ucMGP) and subsequently in extensive arterial calcification. This led us to hypothesize that vitamin K supplementation may slow down the progression of calcification. To test this, we designed the VitaK-CAC trial which analyses effects of menaquinone-7 (MK-7) supplementation on progression of CAC. The trial is a double-blind, randomized, placebo-controlled trial including patients with coronary artery disease (CAD). Patients with a baseline Agatston CAC-score between 50 and 400 will be randomized to an intervention-group (360 microgram MK-7) or a placebo group. Treatment duration will be 24 months. The primary endpoint is the difference in CAC-score progression between both groups. Secondary endpoints include changes in arterial structure and function, and associations with biomarkers. We hypothesize that treatment with MK-7 will slow down or arrest the progression of CAC and that this trial may lead to a treatment option for vascular calcification and subsequent CVD. PMID:26516910

  14. Menaquinone-7 Supplementation to Reduce Vascular Calcification in Patients with Coronary Artery Disease: Rationale and Study Protocol (VitaK-CAC Trial)

    PubMed Central

    Vossen, Liv M.; Schurgers, Leon J.; van Varik, Bernard J.; Kietselaer, Bas L. J. H.; Vermeer, Cees; Meeder, Johannes G.; Rahel, Braim M.; van Cauteren, Yvonne J. M.; Hoffland, Ge A.; Rennenberg, Roger J. M. W.; Reesink, Koen D.; de Leeuw, Peter W.; Kroon, Abraham A.

    2015-01-01

    Coronary artery calcification (CAC) develops early in the pathogenesis of atherosclerosis and is a strong and independent predictor of cardiovascular disease (CVD). Arterial calcification is caused by an imbalance in calcification regulatory mechanisms. An important inhibitor of calcification is vitamin K-dependent matrix Gla protein (MGP). Both preclinical and clinical studies have shown that inhibition of the vitamin K-cycle by vitamin K antagonists (VKA) results in elevated uncarboxylated MGP (ucMGP) and subsequently in extensive arterial calcification. This led us to hypothesize that vitamin K supplementation may slow down the progression of calcification. To test this, we designed the VitaK-CAC trial which analyses effects of menaquinone-7 (MK-7) supplementation on progression of CAC. The trial is a double-blind, randomized, placebo-controlled trial including patients with coronary artery disease (CAD). Patients with a baseline Agatston CAC-score between 50 and 400 will be randomized to an intervention-group (360 microgram MK-7) or a placebo group. Treatment duration will be 24 months. The primary endpoint is the difference in CAC-score progression between both groups. Secondary endpoints include changes in arterial structure and function, and associations with biomarkers. We hypothesize that treatment with MK-7 will slow down or arrest the progression of CAC and that this trial may lead to a treatment option for vascular calcification and subsequent CVD. PMID:26516910

  15. Lewis Acid Binding and Transfer as a Versatile Experimental Gauge of the Lewis Basicity of Fe(0) , Ru(0) , and Pt(0) Complexes.

    PubMed

    Braunschweig, Holger; Brunecker, Carina; Dewhurst, Rian D; Schneider, Christoph; Wennemann, Benedikt

    2015-12-21

    A number of zerovalent ruthenium tri- and tetracarbonyl complexes of the form [Ru(CO)5-n Ln ] (n=1, 2) with neutral phosphine or N-heterocyclic carbene donor ligands have been treated with the Lewis acids GaCl3 and Ag(+) to form a range of metal-only Lewis pairs (MOLPs). The spectroscopic and structural parameters of the adducts are compared to each other and to related iron carbonyl based MOLPs. The Lewis basicity of the original Ru(0) complexes is gauged by transfer experiments, as well as through the degree of pyramidization of the bound GaCl3 units and the RuM bond lengths. The work shows the benefits of the MOLP concept as one of the few direct experimental gauges of metal basicity, and one that can allow comparisons between metal complexes with different metal centers and ligand sets. PMID:26555043

  16. ALUMNI FROM SOUTH DAKOTA SCHOOL OF MINES AND TECHNOLOGY WORKING AT LEWIS FLIGHT PROPULSION LABORATOR

    NASA Technical Reports Server (NTRS)

    1956-01-01

    ALUMNI FROM SOUTH DAKOTA SCHOOL OF MINES AND TECHNOLOGY WORKING AT LEWIS FLIGHT PROPULSION LABORATORY LFPL - LEFT TO RIGHT - CHARLES GRESSLIN - LESTER CORRINGTON - BERTRAM A MULCAHY - FRANZ L LAGERWELL

  17. Lewis Research Center studies of multiple large wind turbine generators on a utility network

    NASA Technical Reports Server (NTRS)

    Gilbert, L. J.; Triezenberg, D. M.

    1979-01-01

    A NASA-Lewis program to study the anticipated performance of a wind turbine generator farm on an electric utility network is surveyed. The paper describes the approach of the Lewis Wind Energy Project Office to developing analysis capabilities in the area of wind turbine generator-utility network computer simulations. Attention is given to areas such as, the Lewis Purdue hybrid simulation, an independent stability study, DOE multiunit plant study, and the WEST simulator. Also covered are the Lewis mod-2 simulation including analog simulation of a two wind turbine system and comparison with Boeing simulation results, and gust response of a two machine model. Finally future work to be done is noted and it is concluded that the study shows little interaction between the generators and between the generators and the bus.

  18. Organo-Lewis acid as cocatalyst for cationic homogenous metallocene Ziegler-Natta olefin polymerizations

    DOEpatents

    Marks, Tobin J.; Chen, You-Xian

    2000-01-01

    The synthesis of the organo-Lewis acid perfluorobiphenylborane (PBB) and the activation of metallocenes for the formation of a variety of highly active homogeneous Ziegler-Natta metallocene olefin polymerization, copolymerization and ring-opening polymerization catalysts is described.

  19. Synergistic effects between Lewis and Brønsted acids: application to the Prins cyclization.

    PubMed

    Breugst, Martin; Grée, René; Houk, K N

    2013-10-01

    Brønsted and Lewis acids can catalyze the Prins cyclization, an efficient method for the synthesis of tetrahydropyrans from homoallylic alcohols and carbonyl compounds. Synergistic effects between weak Brønsted and Lewis acids in these reactions have been analyzed by density functional theory [M06-L/def2-QZVP/IEFPCM(CH2Cl2)//M06-L/6-311+G(2df,2p)]. In order to characterize the reactivities of the employed Lewis acids, methyl anion and hydroxide affinities were determined. On the basis of our calculations, we found that the coordination of Lewis acids to carboxylic and sulfonic acids results in a significant increase in the Brønsted acidities of the latter. PMID:23984760

  20. How Lewis acidic is your cation? Putting phosphenium ions on the fluoride ion affinity scale.

    PubMed

    Slattery, John M; Hussein, Sharifa

    2012-02-14

    The fluoride ion affinities (FIAs) of 33 phosphenium ions with a range of substituents were calculated using ab inito and DFT methods. The use of these FIA data as a measure of the Lewis acidities of phosphenium ions is described and the FIAs of the species studied here are compared to FIA data for more commonly encountered Lewis acids. Phosphenium ions are often stronger Lewis acids than neutral species, but in many cases are less Lewis acidic than highly electrophilic cations such as [Me(3)C](+) or [Me(3)Si](+). The impact of mesomeric, inductive and steric substituent effects on FIAs are discussed and related to the underlying electronic structures of different cation types. A comparison between the FIAs of known "free" phosphenium ions with those that are currently unknown and other highly electrophilic cations suggests that some diaryl- and dialkylphosphenium ions may yet be accessible under the right conditions. PMID:22159000

  1. Advocacy, education, and the role of not-for-profit organizations in Lewy body dementias

    PubMed Central

    2014-01-01

    Lewy body dementias (LBDs) represent a spectrum of dementias that are associated with the presence of Lewy bodies in the brain and that dramatically impact both the person diagnosed and the family caregiver. LBD charities provide education of the public and health-care professionals, emotional support to families, and advocacy to policy-makers on the needs of LBD families and advance research. The US-based Lewy Body Dementia Association and the Lewy Body Society in the UK play an important role in reducing the burden that LBD places on families and society and provide leadership on issues affecting LBD families. Health-care providers are encouraged to refer families upon diagnosis to LBD charities as an additional resource to clinical care. PMID:26082807

  2. Highlighting High Performance: Adam Joseph Lewis Center for Environmental Studies, Oberlin College, Oberlin, Ohio

    SciTech Connect

    2002-11-01

    Oberlin College’s Adam Joseph Lewis Center for Environmental Studies is a high-performance building featuring an expansive photovoltaic system and a closed-loop groundwater heat pump system. Designers incorporated energy-efficient components and materials

  3. Summary of the NASA Lewis component technology program for Stirling power converters

    NASA Technical Reports Server (NTRS)

    Thieme, Lanny G.; Swec, Diane M.

    1992-01-01

    An update is presented on the NASA Lewis Stirling component technology program. The component technology program has been organized as part of the NASA Lewis effort to develop Stirling converter technology for space power applications. The Stirling space power project is part of the High Capacity Power element of the NASA Civil Space Technology Initiative (CSTI). Lewis is also providing technical management of a DOE funded project to develop Stirling converter systems for distributed dish solar terrestrial power applications. The primary contractors for the space power and solar terrestrial projects develop component technologies directly related to their project goals. This Lewis component technology program, while coordinated with these main projects, is aimed at longer term issues, advanced technologies, and independent assessments. Topics to be discussed include bearings, linear alternators, controls and load interaction, materials/life assessment, and heat exchangers.

  4. [Book review] The youngest science: notes of a medicine-watcher, by Lewis Thomas

    USGS Publications Warehouse

    Johnson, D.H.

    1984-01-01

    Review of: The youngest science: notes of a medicine-watcher. Alfred P. Sloan Foundation Series. Lewis Thomas. Penguin Books, 1995. Pennsylvania State University. 270 pp. ISBN: 0140243275, 9780140243277.

  5. Functional connectivity in cortical regions in dementia with Lewy bodies and Alzheimer's disease.

    PubMed

    Kenny, Eva R; Blamire, Andrew M; Firbank, Michael J; O'Brien, John T

    2012-02-01

    Using resting-state functional magnetic resonance imaging, spontaneous low-frequency fluctuations in the blood oxygenation level-dependent signal were measured to investigate connectivity between key brain regions hypothesized to be differentially affected in dementia with Lewy bodies compared with Alzheimer's disease and healthy controls. These included connections of the hippocampus, because of its role in learning, and parietal and occipital areas involved in memory, attention and visual processing. Connectivity was investigated in 47 subjects aged 60 years and over: 15 subjects with dementia with Lewy bodies, 16 subjects with Alzheimer's disease and 16 control subjects. Subjects were scanned using a 3 Tesla magnetic resonance imaging system. The mean blood oxygenation level-dependent signal time series was extracted from seed regions in the hippocampus, posterior cingulate cortex, precuneus and primary visual cortex and correlated with all other brain voxels to determine functional connectivity. Both subjects with dementia with Lewy bodies and Alzheimer's disease showed greater connectivity than control subjects. Compared with controls, the dementia with Lewy bodies group had greater connectivity between the right posterior cingulate cortex and other brain areas. In dementia with Lewy bodies, there were no significant differences in hippocampal connectivity compared with controls, but in Alzheimer's disease left hippocampal connectivity was greater compared with controls. There were no significant differences between groups for precuneus or primary visual cortex connectivity. No seed regions showed significantly less connectivity in subjects with dementia with Lewy bodies or Alzheimer's disease compared with controls. We found greater connectivity with the posterior cingulate in dementia with Lewy bodies and with the hippocampus in Alzheimer's disease. Consistent with the known relative preservation of memory in dementia with Lewy bodies compared with Alzheimer's disease, hippocampal connectivity was not found to be greater in dementia with Lewy bodies. Importantly, while metabolic imaging shows functional change in primary visual cortex in dementia with Lewy bodies, which is hypothesized to account for visual hallucinations, we found connectivity with this region to be unaffected. This implicates areas beyond visual sensory input level in the visual symptoms and visual-perceptual dysfunction seen in dementia with Lewy bodies. PMID:22189566

  6. Shell shock at Queen Square: Lewis Yealland 100 years on.

    PubMed

    Linden, Stefanie C; Jones, Edgar; Lees, Andrew J

    2013-06-01

    This article reviews the treatment of functional neurological symptoms during World War I by Lewis Yealland at the National Hospital for the Paralysed and Epileptic in London. Yealland was among the first doctors in Britain to incorporate electricity in the systematic treatment of shell shock. Our analysis is based on the original case records of his treatment of 196 soldiers with functional motor and sensory symptoms, functional seizures and somatoform disorders. Yealland's treatment approach integrated peripheral and central electrical stimulation with a variety of other--psychological and physical--interventions. A combination of electrical stimulation of affected muscles with suggestion of imminent improvement was the hallmark of his approach. Although his reported success rates were high, Yealland conducted no formal follow-up. Many of the principles of his treatment, including the emphasis on suggestion, demonstration of preserved function and the communication of a physiological illness model, are encountered in current therapeutic approaches to functional motor and sensory symptoms. Yealland has been attacked for his use of electrical stimulation and harsh disciplinary procedures in popular and scientific literature during and after World War I. This criticism reflects changing views on patient autonomy and the social role of doctors and directly impacts on current debates on ethical justification of suggestive therapies. We argue that knowledge of the historical approaches to diagnosis and management of functional neurological syndromes can inform both aetiological models and treatment concepts for these challenging conditions. PMID:23384604

  7. Olfactory dysfunction in incidental Lewy body disease and Parkinson's disease

    PubMed Central

    Driver-Dunckley, Erika; Adler, Charles H.; Hentz, Joseph G.; Dugger, Brittany N.; Shill, Holly A.; Caviness, John N.; Sabbagh, Marwan N.; Beach, Thomas G.

    2016-01-01

    Background Olfactory dysfunction in Parkinson's disease (PD) is well-established and may represent one of the earliest signs of the disease. Objective & methods The objective of this study was to evaluate the relationship of olfactory dysfunction, using the University of Pennsylvania Smell Identification Test (UPSIT), to clinical and pathological parameters of clinicopathologically diagnosed PD (n = 10), incidental Lewy body disease (ILBD) (n = 13), and identically assessed controls who lacked a neurodegenerative disease (n = 69). Results Mean UPSIT scores were significantly lower in PD (16.3, p < 0.001) and ILBD (22.2, p = 0.004) compared to controls (27.7). Using an UPSIT cutoff score of <22 (the 15th percentile) the sensitivity for detecting PD was 9/10 (90%) and ILBD 6/13 (46%), while the specificity was 86% (Controls with score of <22 = 10/69). Conclusions = These results add to the growing body of evidence suggesting that olfactory testing could be useful as a screening tool for identifying early, pre-motor PD. PMID:25172126

  8. False recognition in Lewy-body disease and frontotemporal dementia.

    PubMed

    de Boysson, C; Belleville, S; Phillips, N A; Johns, E K; Goupil, D; Souchay, C; Bouchard, R; Chertkow, H

    2011-03-01

    The primary goal of this study was to evaluate the false recognition phenomenon in persons with frontotemporal dementia (FTD) and those with Lewy-body disease (LBD). Patients with LBD (n=10) or FTD (n=15) and their corresponding controls (n=30) were subjected to the Deese-Roediger-McDermott (DRM) paradigm to induce false recognition. Patients were first presented with items semantically related to a nonpresented critical target. The critical target was later included in a word list shown to patients to assess level of recognition. Both groups of patients showed a reduced level of false recognition of the critical target when controlling for their overall level of false alarms. This reduction was greater in persons with LBD than in those with FTD. Correlational analyses of performance on neuropsychological tests and the DRM variables indicated that the reduced DRM effect was associated with inhibition deficits in patients with LBD and with inhibition deficits and verbal memory in those with FTD. Our results support current models suggesting that these cognitive components contribute to the false recognition effect. PMID:21094574

  9. Exploring the role of donepezil in dementia with Lewy bodies.

    PubMed

    Szigeti, K; Hafeez, M U

    2015-10-01

    Dementia with Lewy bodies (DLB) is considered the second most common form of dementia in the elderly. The cognitive fluctuations, hallucinations and extrapyramidal symptoms and signs suggest simultaneous neurodegeneration in multiple neuronal pathways including both dopaminergic and cholinergic transmission. In the past few years, several small studies have demonstrated the benefit of acetylcholinesterase inhibitors (AChEIs) on the cognitive and behavioral symptoms of DLB. These drugs, by reversibly blocking the hydrolytic activity of AChE, increase the availability of synaptic acetylcholine. Neuropathological and neuroimaging studies demonstrated that cholinergic neurotransmission is more defective in DLB than in Alzheimer's disease (AD). Despite the relevance of AChEIs to DLB, there are no FDA-approved drugs for its management. The aim of this review is to summarize the literature on the application of donepezil in DLB. Although the results are inconclusive, when one compares and contrasts them to the results of the AD-donepezil trials, the effect size appears larger. Placebo-controlled, randomized, well-powered studies of adequate length are needed to avoid underutilization of a potentially efficacious drug. PMID:26583300

  10. NASA Lewis Research Center's Preheated Combustor and Materials Test Facility

    NASA Technical Reports Server (NTRS)

    Nemets, Steve A.; Ehlers, Robert C.; Parrott, Edith

    1995-01-01

    The Preheated Combustor and Materials Test Facility (PCMTF) in the Engine Research Building (ERB) at the NASA Lewis Research Center is one of two unique combustor facilities that provide a nonvitiated air supply to two test stands, where the air can be used for research combustor testing and high-temperature materials testing. Stand A is used as a research combustor stand, whereas stand B is used for cyclic and survivability tests of aerospace materials at high temperatures. Both stands can accommodate in-house and private industry research programs. The PCMTF is capable of providing up to 30 lb/s (pps) of nonvitiated, 450 psig combustion air at temperatures ranging from 850 to 1150 g F. A 5000 gal tank located outdoors adjacent to the test facility can provide jet fuel at a pressure of 900 psig and a flow rate of 11 gal/min (gpm). Gaseous hydrogen from a 70,000 cu ft (CF) tuber is also available as a fuel. Approximately 500 gpm of cooling water cools the research hardware and exhaust gases. Such cooling is necessary because the air stream reaches temperatures as high as 3000 deg F. The PCMTF provides industry and Government with a facility for studying the combustion process and for obtaining valuable test information on advanced materials. This report describes the facility's support systems and unique capabilities.

  11. NASA Lewis steady-state heat pipe code users manual

    NASA Technical Reports Server (NTRS)

    Tower, Leonard K.; Baker, Karl W.; Marks, Timothy S.

    1992-01-01

    The NASA Lewis heat pipe code was developed to predict the performance of heat pipes in the steady state. The code can be used as a design tool on a personal computer or with a suitable calling routine, as a subroutine for a mainframe radiator code. A variety of wick structures, including a user input option, can be used. Heat pipes with multiple evaporators, condensers, and adiabatic sections in series and with wick structures that differ among sections can be modeled. Several working fluids can be chosen, including potassium, sodium, and lithium, for which monomer-dimer equilibrium is considered. The code incorporates a vapor flow algorithm that treats compressibility and axially varying heat input. This code facilitates the determination of heat pipe operating temperatures and heat pipe limits that may be encountered at the specified heat input and environment temperature. Data are input to the computer through a user-interactive input subroutine. Output, such as liquid and vapor pressures and temperatures, is printed at equally spaced axial positions along the pipe as determined by the user.

  12. Enamine/butadienylborane cycloaddition in the frustrated Lewis pair regime.

    PubMed

    Chen, Guo-Qiang; Türkyilmaz, Fatma; Daniliuc, Constantin G; Bannwarth, Christoph; Grimme, Stefan; Kehr, Gerald; Erker, Gerhard

    2015-11-14

    The dienylborane 2a was prepared by regioselective alkyne hydroboration of the conjugated enyne 1a with Piers' borane [HB(C6F5)2]. Its reaction with a series of acetophenone derived enamines 3 resulted in the formation of the strong enamine β-carbon adduct with the borane Lewis acid (4). In contrast B-C adduct formation between the dienylborane 2a and a series of much more bulky cyclohexanone derived enamines (6) is rapidly reversible above ca.-30 °C and then leads to the formation of the [4 + 2]cycloaddition products 8. A DFT study revealed that this reaction is probably taking a stepwise route, proceeding by means of enamine addition to the dienylborane terminus to generate a zwitterionic borata-alkene/iminium ion intermediate that undergoes rapid subsequent ring closure. Heating of the products 8 led to amidoborane elimination from the vicinal amino/borane pair at the product framework to give the respective hexahydronaphthalene product 10. Subsequent treatment with TEMPO (2 equiv.) resulted in selective oxidation of the unsaturated ring to give the respective tetrahydronaphthalene derivative 12. PMID:26330093

  13. NASA Lewis steady-state heat pipe code users manual

    SciTech Connect

    Tower, L.K.; Baker, K.W.; Marks, T.S.

    1992-06-01

    The NASA Lewis heat pipe code has been developed to predict the performance of heat pipes in the steady state. The code can be used as a design tool on a personal computer or, with a suitable calling routine, as a subroutine for a mainframe radiator code. A variety of wick structures, including a user input option, can be used. Heat pipes with multiple evaporators, condensers, and adiabatic sections in series and with wick structures that differ among sections can be modeled. Several working fluids can be chosen, including potassium, sodium, and lithium, for which the monomer-dimer equilibrium is considered. The code incorporates a vapor flow algorithm that treats compressibility and axially varying heat input. This code facilitates the determination of heat pipe operating temperatures and heat pipe limits that may be encountered at the specified heat input and environment temperature. Data are input to the computer through a user-interactive input subroutine. Output, such as liquid and vapor pressures and temperatures, is printed at equally spaced axial positions along the pipe as determined by the user.

  14. Fort Lewis electric energy baseline and efficiency resource assessment

    SciTech Connect

    Secrest, T.J.; Currie, J.W.; DeSteese, J.G.; Dirks, J.A.; Marseille, T.J.; Parker, G.B.; Richman, E.E.; Shankle, S.A.

    1991-10-01

    In support of the US DOE Federal Energy Management Program, the Pacific Northwest Laboratory is developing a fuel-neutral approach for identifying, evaluating, and acquiring all cost-effective energy projects at federal installations. Fort Lewis, a US Army installation near Tacoma, Washington, was selected as the pilot site for developing this approach. This site was chosen in conjunction with the interests of the Bonneville Power Administration to develop programs for its federal sector customers and the Army Forces Command to develop an in-house program to upgrade the energy efficiency of its installations. This report documents the electricity assessment portion of the approach, providing an estimate of the electricity use baseline and efficiency improvement potential for major sectors and end uses at the Fort. Although the assessment did not identify all possible efficiency improvement opportunities, it is estimated that electricity use can be reduced by at least 20% cost-effectively at the $0.045/kWh marginal cost of electricity in the Pacific Northwest. 12 refs., 3 figs., 7 tabs.

  15. Lewis-Riesenfeld invariants and transitionless quantum driving

    SciTech Connect

    Chen Xi; Torrontegui, E.; Muga, J. G.

    2011-06-15

    Different methods have been recently put forward and implemented experimentally to inverse engineer the time-dependent Hamiltonian of a quantum system and accelerate slow adiabatic processes via nonadiabatic shortcuts. In the ''transitionless quantum driving'' proposed by Berry, shortcut Hamiltonians are designed so that the system follows exactly, in an arbitrarily short time, the approximate adiabatic path defined by a reference Hamiltonian. A different approach is based on first designing a Lewis-Riesenfeld invariant to carry the eigenstates of a Hamiltonian from specified initial to final configurations, again in an arbitrary time, and then constructing from the invariant the transient Hamiltonian that connects these boundary configurations. We show that the two approaches, apparently quite different in form and so far in results, are, in fact, strongly related and potentially equivalent, so that the inverse-engineering operations in one of them can be reinterpreted and understood in terms of the concepts and operations of the other one. We study, as explicit examples, expansions of time-dependent harmonic traps and the state preparation of two-level systems.

  16. Shell shock at Queen Square: Lewis Yealland 100 years on

    PubMed Central

    Jones, Edgar; Lees, Andrew J.

    2013-01-01

    This article reviews the treatment of functional neurological symptoms during World War I by Lewis Yealland at the National Hospital for the Paralysed and Epileptic in London. Yealland was among the first doctors in Britain to incorporate electricity in the systematic treatment of shell shock. Our analysis is based on the original case records of his treatment of 196 soldiers with functional motor and sensory symptoms, functional seizures and somatoform disorders. Yealland’s treatment approach integrated peripheral and central electrical stimulation with a variety of other—psychological and physical—interventions. A combination of electrical stimulation of affected muscles with suggestion of imminent improvement was the hallmark of his approach. Although his reported success rates were high, Yealland conducted no formal follow-up. Many of the principles of his treatment, including the emphasis on suggestion, demonstration of preserved function and the communication of a physiological illness model, are encountered in current therapeutic approaches to functional motor and sensory symptoms. Yealland has been attacked for his use of electrical stimulation and harsh disciplinary procedures in popular and scientific literature during and after World War I. This criticism reflects changing views on patient autonomy and the social role of doctors and directly impacts on current debates on ethical justification of suggestive therapies. We argue that knowledge of the historical approaches to diagnosis and management of functional neurological syndromes can inform both aetiological models and treatment concepts for these challenging conditions. PMID:23384604

  17. Cyclic Oxidation Testing and Modelling: A NASA Lewis Perspective

    NASA Technical Reports Server (NTRS)

    Smialek, J. L.; Nesbitt, J. A.; Barrett, C. A.; Lowell, C. E.

    2000-01-01

    The Materials Division of the NASA Lewis Research Center has been heavily involved in the cyclic oxidation of high temperature materials for 30 years. Cyclic furnace and burner rig apparati have been developed, refined, and replicated to provide a large scale facility capable of evaluating many materials by a standard technique. Material behavior is characterized by weight change data obtained throughout the test, which has been modelled in a step-wise process of scale growth and spallation. This model and a coupled diffusion model have successfully described cyclic behavior for a number of systems and have provided insights regarding life prediction and variations in the spalling process. Performance ranking and mechanistic studies are discussed primarily for superalloys and coating alloys. Similar cyclic oxidation studies have been performed on steels, intermetallic compounds, thermal barrier coatings, ceramics, and ceramic composites. The most common oxidation test was performed in air at temperatures ranging from 800 deg. to 1600 C, for times up to 10000 h, and for cycle durations of 0.1 to 1000 h. Less controlled, but important, test parameters are the cooling temperature and humidity level. Heating and cooling rates are not likely to affect scale spallation. Broad experience has usually allowed for considerable focus and simplification of these test parameters, while still revealing the principal aspects of material behavior and performance. Extensive testing has been performed to statistically model the compositional effects of experimental alloys and to construct a comprehensive database of complex commercial alloys.

  18. LSENS, The NASA Lewis Kinetics and Sensitivity Analysis Code

    NASA Technical Reports Server (NTRS)

    Radhakrishnan, K.

    2000-01-01

    A general chemical kinetics and sensitivity analysis code for complex, homogeneous, gas-phase reactions is described. The main features of the code, LSENS (the NASA Lewis kinetics and sensitivity analysis code), are its flexibility, efficiency and convenience in treating many different chemical reaction models. The models include: static system; steady, one-dimensional, inviscid flow; incident-shock initiated reaction in a shock tube; and a perfectly stirred reactor. In addition, equilibrium computations can be performed for several assigned states. An implicit numerical integration method (LSODE, the Livermore Solver for Ordinary Differential Equations), which works efficiently for the extremes of very fast and very slow reactions, is used to solve the "stiff" ordinary differential equation systems that arise in chemical kinetics. For static reactions, the code uses the decoupled direct method to calculate sensitivity coefficients of the dependent variables and their temporal derivatives with respect to the initial values of dependent variables and/or the rate coefficient parameters. Solution methods for the equilibrium and post-shock conditions and for perfectly stirred reactor problems are either adapted from or based on the procedures built into the NASA code CEA (Chemical Equilibrium and Applications).

  19. Lower hybrid emission diagnostics on the NASA Lewis Bumpy Torus

    NASA Technical Reports Server (NTRS)

    Mallavarpu, R.

    1977-01-01

    The feasibility of using RF emission near the lower-hybrid frequency of the NASA Lewis Bumpy Torus plasma for diagnostic purposes is examined. The emission is detected using a spectrum analyzer and a 50-ohm miniature coaxial antenna that is sensitive to the polarization of the incoming signal. The frequency shift of the lower-hybrid emission peak is monitored as a function of the background pressure, electrode voltage, electrode ring configuration, and the strength of the toroidal dc magnetic field. Simultaneous measurements of the average plasma density are made with a polarization diplexing microwave interferometer. The experimental results extend previous work to include negative electrode voltages and plasma densities up to 1 trillion per cu cm. The information derived from the experiment is discussed with reference to: (1) the strength of the dc magnetic field in the emitting region, (2) a comparison of the lower-hybrid plasma density with the average plasma density, and (3) the validity of the cold-plasma lower-hybrid resonance formula in the high-density operating regime of the bumpy-torus plasma.

  20. Cognitive impairment in Parkinson's disease and dementia with Lewy bodies.

    PubMed

    Aarsland, Dag

    2016-01-01

    Parkinson's disease (PD) and dementia with Lewy bodies (DLB) share clinical and pathological similarities. The defining features are motor parkinsonism and cognitive impairment, often accompanied by visual hallucinations, fluctuating consciousness, autonomic and sleep disturbances, and a number of other non-motor symptoms. Mild cognitive impairment (MCI) can be identified in 15% of PD patients at time of diagnosis, and may even precede motor symptoms. MCI usually progresses further, and dementia is a common endpoint. Cognitive impairment is usually the initial symptom of DLB, and the disease course is severe. A variety of biomarkers can assist in the diagnosis and prognosis of PD and DLB, including structural and functional imaging, cerebrospinal fluid, and EEG. Compared to the many treatments available for motor symptoms, relatively few systematic studies exist to guide the treatment of cognitive impairment in PD, and even less in DLB. However, there is good evidence for cholinesterase inhibitors in both DLB and PD with dementia, and some indications that memantine is helpful. Emerging evidence suggest that physical exercise and cognitive training are also effective, as are some reports of various brain stimulation techniques. Disease-modifying agents that delay the rate of cognitive decline in PD and DLB are urgently needed. PMID:26411499

  1. Activities of the Structures Division, Lewis Research Center

    NASA Astrophysics Data System (ADS)

    The purpose of the NASA Lewis Research Center, Structures Division's 1990 Annual Report is to give a brief, but comprehensive, review of the technical accomplishments of the Division during the past calendar year. The report is organized topically to match the Center's Strategic Plan. Over the years, the Structures Division has developed the technology base necessary for improving the future of aeronautical and space propulsion systems. In the future, propulsion systems will need to be lighter, to operate at higher temperatures and to be more reliable in order to achieve higher performance. Achieving these goals is complex and challenging. Our approach has been to work cooperatively with both industry and universities to develop the technology necessary for state-of-the-art advancement in aeronautical and space propulsion systems. The Structures Division consists of four branches: Structural Mechanics, Fatigue and Fracture, Structural Dynamics, and Structural Integrity. This publication describes the work of the four branches by three topic areas of Research: (1) Basic Discipline; (2) Aeropropulsion; and (3) Space Propulsion. Each topic area is further divided into the following: (1) Materials; (2) Structural Mechanics; (3) Life Prediction; (4) Instruments, Controls, and Testing Techniques; and (5) Mechanisms. The publication covers 78 separate topics with a bibliography containing 159 citations. We hope you will find the publication interesting as well as useful.

  2. Thalidomide prolongs experimental autoimmune neuritis in Lewis rats.

    PubMed

    Zhu, J; Deng, G M; Diab, A; Zwingenberger, K; Bakhiet, M; Link, H

    1998-10-01

    Thalidomide is reported to have immunomodulatory and anti-inflammatory effects, which have led to its use in the treatment of a number of immune-mediated disorders, including leprosy, discoid lupus and Behcet's disease, and to prevent immunological rejection phenomena following skin and bone marrow grafts. Experimental autoimmune neuritis (EAN) is a CD4+ T-cell-mediated demyelinating autoimmune disease, which represents an animal model for the study of the immunopathogenesis and immunotherapy of Guillain-Barré syndrome (GBS) in humans. We examined the effect of thalidomide in Lewis rats with EAN, which was induced by immunization with bovine peripheral nerve myelin (BPM) and complete Freund's adjuvant (CFA). Thalidomide prolonged clinical EAN when given at a dose of 200 mg/kg/day by gavage. This clinical effect was associated with increased numbers of inflammatory cells in sciatic nerve sections and elevated numbers of interferon-gamma (IFN-gamma) mRNA-expressing cells among lymph node mononuclear cells from thalidomide-treated EAN rats on day 17 postimmunization, i.e. at the peak of clinical EAN. The finding that thalidomide prolongs clinical EAN is in agreement with the clinical polyneuropathy reported in patients receiving treatment with thalidomide and limits its clinical usefulness. PMID:9790310

  3. Lewis acid catalyzed trans-hydrostannation of acetylenes

    SciTech Connect

    Asao, Naoki; Liu, Jian-Xiu; Sudoh, Tomoko; Yamamoto, Yoshinori

    1995-12-31

    A Lewis acid such as ZrCl{sub 4} or HfCl{sub 4} catalyzed the hydrostannation of acetylenes 1 to produce the trans-hydrostannation products 2 regio- and stereoselectively. The use of non-polar solvents such as toluene or hexane was essential for obtaining high stereoselectivity and chemical yield. Since ZrCl{sub 4} or HfCl{sub 4} is not soluble in such solvents, this hydrostannation process was carried out in heterogeneous system. The reactions of internal acetylenes proceeded smoothly, although the use of stoichiometric amounts of ZrCl{sub 4} gave better results. The ZrCl{sub 4} catalyzed hydrostannation of 1-octyne with Bu{sub 3}SnH was monitored by {sup 1}H and {sup 119}Sn NMR spectroscopy, and it was found that an equilibrium process was involved in ZrCl{sub 4}-Bu{sub 3}SnH system and that a complex formed from Bu{sub 3}SnH and ZrCl{sub 4} would be a reactive species.

  4. NASA Lewis Research Center's combustor test facilities and capabilities

    NASA Technical Reports Server (NTRS)

    Bianco, Jean

    1995-01-01

    NASA Lewis Research Center (LeRC) presently accommodates a total of six combustor test facilities with unique capabilities. The facilities are used to evaluate combustor and afterburner concepts for future engine applications, and also to test the survivability and performance of innovative high temperature materials, new instrumentation, and engine components in a realistic jet engine environment. The facilities provide a variety of test section interfaces and lengths to allow for flametube, sector and component testing. The facilities can accommodate a wide range of operating conditions due to differing capabilities in the following areas: inlet air pressure, temperature, and flow; fuel flow rate, pressure, and fuel storage capacity; maximum combustion zone temperature; cooling water flow rate and pressure; types of exhaust - atmospheric or altitude; air heater supply pressure; and types of air heaters - vitiated or nonvitiated. All of the facilities have provisions for standard gas (emissions) analysis, and a few of the facilities are equipped with specialized gas analysis equipment, smoke and particle size measurement devices, and a variety of laser systems. This report will present some of the unique features of each of the high temperature/high pressure combustor test facilities at NASA LeRC.

  5. Prodromal clinical manifestations of neuropathologically confirmed Lewy body disease.

    PubMed

    Jicha, G A; Schmitt, F A; Abner, E; Nelson, P T; Cooper, G E; Smith, C D; Markesbery, W R

    2010-10-01

    The mild cognitive impairment (MCI) stage of dementia with Lewy bodies (MCI-DLB) has not yet been defined, but is likely to differ in the MCI stage of Alzheimer's disease (MCI-AD). To determine whether clinical features distinguish MCI-DLB and MCI-AD, 9 cases of neuropathologically confirmed MCI-DLB and 12 cases of MCI-AD were compared. No significant differences were found between MCI-DLB and MCI-AD cases in age at death, gender, ApoE status, education, time followed while clinically normal, or duration of MCI. MCI-DLB and MCI-AD cases differed clinically in the expression of Parkinsonism (P=0.012), provoked hallucinations or delirium (P=0.042), or the presence of any of these noncognitive symptoms of DLB (P<0.0001). Letter fluency (P=0.007) was significantly lower and Wechsler Logical Memory I (P=0.019) was significantly higher in MCI-DLB compared to MCI-AD cases. These data demonstrate the feasibility of differentiating underlying pathologic processes responsible for cognitive decline in the preclinical disease state and suggest that further refinement in diagnostic criteria may allow more accurate early detection of prodromal DLB and AD. PMID:19026468

  6. Cerebrospinal Fluid Biomarkers for Dementia with Lewy Bodies

    PubMed Central

    Mukaetova-Ladinska, Elizabeta B.; Monteith, Rachael; Perry, Elaine K.

    2010-01-01

    More than 750,000 of the UK population suffer from some form of cognitive impairment and dementia. Of these, 5–20% will have Dementia with Lewy Bodies (DLB). Clinico-pathological studies have shown that it is the low frequency of DLB clinical core features that makes the DLB diagnosis hardly recognisable during life, and easily misdiagnosed for other forms of dementia. This has an impact on the treatment and long-term care of the affected subjects. Having a biochemical test, based on quantification of a specific DLB biomarker within Cerebrospinal Fluid (CSF) could be an effective diagnostic method to improve the differential diagnosis. Although some of the investigated DLB CSF biomarkers are well within the clinical criteria for sensitivity and specificity (>90%), they all seem to be confounded by the contradictory data for each of the major groups of biomarkers (α-synuclein, tau and amyloid proteins). However, a combination of CSF measures appear to emerge, that may well be able to differentiate DLB from other dementias: α-synuclein reduction in early DLB, a correlation between CSF α-synuclein and Aβ42 measures (characteristic for DLB only), and t-tau and p-tau181 profile (differentiating AD from DLB). PMID:21048932

  7. Activities of the Structures Division, Lewis Research Center

    NASA Technical Reports Server (NTRS)

    1990-01-01

    The purpose of the NASA Lewis Research Center, Structures Division's 1990 Annual Report is to give a brief, but comprehensive, review of the technical accomplishments of the Division during the past calendar year. The report is organized topically to match the Center's Strategic Plan. Over the years, the Structures Division has developed the technology base necessary for improving the future of aeronautical and space propulsion systems. In the future, propulsion systems will need to be lighter, to operate at higher temperatures and to be more reliable in order to achieve higher performance. Achieving these goals is complex and challenging. Our approach has been to work cooperatively with both industry and universities to develop the technology necessary for state-of-the-art advancement in aeronautical and space propulsion systems. The Structures Division consists of four branches: Structural Mechanics, Fatigue and Fracture, Structural Dynamics, and Structural Integrity. This publication describes the work of the four branches by three topic areas of Research: (1) Basic Discipline; (2) Aeropropulsion; and (3) Space Propulsion. Each topic area is further divided into the following: (1) Materials; (2) Structural Mechanics; (3) Life Prediction; (4) Instruments, Controls, and Testing Techniques; and (5) Mechanisms. The publication covers 78 separate topics with a bibliography containing 159 citations. We hope you will find the publication interesting as well as useful.

  8. Pathologic correlates of dementia in individuals with Lewy body disease.

    PubMed

    Sonnen, Joshua A; Postupna, Nadia; Larson, Eric B; Crane, Paul K; Rose, Shannon E; Montine, Kathleen S; Leverenz, James B; Montine, Thomas J

    2010-05-01

    Cognitive impairment and dementia are more common in patients with Parkinson disease (PD) than age-matched controls and appear to become more frequent as PD progresses. However, estimates of dementia in patients with PD have varied widely, likely due in part to differences in case definition, case ascertainment and methodology. First, we review investigations of usual pathologic correlates of dementia in patients with brainstem (b) Lewy Body Disease (LBD) and report our findings from the initial 266 brain autopsies from a population-based study of brain aging and incident dementia. Our results showed that 2.6% of subjects were diagnosed with PD during life but that 20% had bLBD at autopsy. Seventy percent of individuals with bLBD had high level of one or more cerebral pathologic changes significantly associated with dementia: Alzheimer's disease (AD), cerebral (c) LBD or microvascular brain injury (microVBI); these were commonly co-morbid. Next we consider proposed contributors to cognitive impairment and dementia in the approximately 30% of patients with only bLBD, including regionally selective dendritic degeneration of neostriatal medium spiny neurons. Diseases contributing to cognitive impairment and dementia in patients with bLBD are heterogeneous, providing diagnostic challenges as well as multiple opportunities for successful intervention in patients with PD. PMID:20522091

  9. An Engineering Approach to Management of Occupational and Community Noise Exposure at NASA Lewis Research Center

    NASA Technical Reports Server (NTRS)

    Cooper, Beth A.

    1997-01-01

    Workplace and environmental noise issues at NASA Lewis Research Center are effectively managed via a three-part program that addresses hearing conservation, community noise control, and noise control engineering. The Lewis Research Center Noise Exposure Management Program seeks to limit employee noise exposure and maintain community acceptance for critical research while actively pursuing engineered controls for noise generated by more than 100 separate research facilities and the associated services required for their operation.

  10. Plans and status of the NASA-Lewis Research Center wind energy project

    NASA Technical Reports Server (NTRS)

    Thomas, R.; Puthoff, R.; Savino, J.; Johnson, W.

    1975-01-01

    Wind energy is investigated as a source of energy. The wind energy program that is managed by the NASA-Lewis Research Center is described. The Lewis Research Center's Wind Power Office, its organization, plans, and status are discussed. Major elements of the wind power project included are: an experimental 100 kW wind-turbine generator; first generation industry-built and user-operated wind turbine generators; and supporting research and technology tasks.

  11. New outcomes of Lewis base addition to diboranes(4): electronic effects override strong steric disincentives.

    PubMed

    Arnold, Nicole; Braunschweig, Holger; Damme, Alexander; Dewhurst, Rian D; Pentecost, Leanne; Radacki, Krzysztof; Stellwag-Konertz, Sascha; Thiess, Torsten; Trumpp, Alexandra; Vargas, Alfredo

    2016-04-01

    Two surprising new outcomes of the reaction of Lewis bases with dihalodiboranes(4) are presented, including sp(2)-sp(3) diboranes in which the Lewis base unit is bound to a highly sterically congested boron atom, and a rearranged double base adduct. The results provide a fuller understanding of the reactivity of diboranes, a poorly-understood class of molecule of critical importance to synthetic organic chemistry. PMID:26974684

  12. Thioarsenides: a case for long-range Lewis acid-base-directed van der Waals interactions

    NASA Astrophysics Data System (ADS)

    Gibbs, G. V.; Wallace, A. F.; Downs, R. T.; Ross, N. L.; Cox, D. F.; Rosso, K. M.

    2011-04-01

    Electron density distributions, bond paths, Laplacian and local-energy density properties have been calculated for a number of As4S n ( n = 3, 4 and 5) thioarsenide molecular crystals. On the basis of the distributions, the intramolecular As-S and As-As interactions classify as shared bonded interactions, and the intermolecular As-S, As-As and S-S interactions classify as closed-shell van der Waals (vdW) bonded interactions. The bulk of the intermolecular As-S bond paths link regions of locally concentrated electron density (Lewis-base regions) with aligned regions of locally depleted electron density (Lewis-acid regions) on adjacent molecules. The paths are comparable with intermolecular paths reported for several other molecular crystals that link aligned Lewis base and acid regions in a key-lock fashion, interactions that classified as long-range Lewis acid-base-directed vdW interactions. As the bulk of the intermolecular As-S bond paths (~70%) link Lewis acid-base regions on adjacent molecules, it appears that molecules adopt an arrangement that maximizes the number of As-S Lewis acid-base intermolecular bonded interactions. The maximization of the number of Lewis acid-base interactions appears to be connected with the close-packed array adopted by molecules: distorted cubic close-packed arrays are adopted for alacránite, pararealgar, uzonite, realgar and β-AsS and the distorted hexagonal close-packed arrays adopted by α- and β-dimorphite. A growth mechanism is proposed for thioarsenide molecular crystals from aqueous species that maximizes the number of long-range Lewis acid-base vdW As-S bonded interactions with the resulting directed bond paths structuralizing the molecules as a molecular crystal.

  13. The Lewis thrust fault and related structures in the Disturbed Belt, northwestern Montana

    USGS Publications Warehouse

    Mudge, Melville Rhodes; Earhart, Robert L.

    1980-01-01

    The classical Lewis thrust fault in Glacier National Park has now been mapped 125 km south of the park to Steamboat Mountain, where the trace dies out in folded middle Paleozoic rocks. The known length of the fault is 452 km, extending northward from Steamboat Mountain to a point 225 km into Canada, where the fault also dies out in Paleozoic rocks. At the south end, the surface expression of the Lewis thrust begins in a shear zone in folded Mississippian rocks. To the north, the thrust progressively cuts downsection into Proterozoic Y (Belt) rocks near Glacier National Park. Displacement on the Lewis plate increases northward from approximately 3 km on an easterly trending hinge line at the West Fork of the Sun River to a postulated 65 km at the southern edge of the park, where the stratigraphic throw is about 6,500 m. Present data indicate the thrust formed during very late Paleocene to very early Eocene time. The Lewis thrust and related structures, the Hoadley thrust and the Continental Divide syncline, probably formed concurrently under the same stress field. The northern limit of the trace of the Hoadley thrust is within the lower portion of the Lewis plate, about 28 km north of where the Lewis thrust develops, and the Hoadley extends for at least 125 km to the south. Displacement of the Hoadley increases southward from about 1 km at the hinge line to an inferred 70 km near its known southern extent. If our inference is correct, the Hoadley is nearly the southern mirror image of the Lewis to the north. The Continental Divide syncline, a doubly plunging, broad, northerly trending open fold that is about 120 km long, is a major fold within the Lewis plate.

  14. Thioarsenides: A case for long-range Lewis acid-base-directed van der Waals interactions

    SciTech Connect

    Gibbs, Gerald V.; Wallace, Adam F.; Downs, R. T.; Ross, Nancy L.; Cox, David F.; Rosso, Kevin M.

    2011-04-01

    Electron density distributions, bond paths, Laplacian and local energy density properties have been calculated for a number of As4Sn (n = 3,4,5) thioarsenide molecular crystals. On the basis of the distributions, the intramolecular As-S and As-As interactions classify as shared bonded interactions and the intermolecular As-S, As-As and S-S interactions classify as closed-shell van der Waals bonded interactions. The bulk of the intermolecular As-S bond paths link regions of locally concentrated electron density (Lewis base regions) with aligned regions of locally depleted electron density (Lewis acid regions) on adjacent molecules. The paths are comparable with intermolecular paths reported for several other molecular crystals that link aligned Lewis base and acid regions in a key-lock fashion, interactions that classified as long range Lewis acid-base directed van der Waals interactions. As the bulk of the intermolecular As-S bond paths (~70%) link Lewis acid-base regions on adjacent molecules, it appears that molecules adopt an arrangement that maximizes the number of As-S Lewis acid-base intermolecular bonded interactions. The maximization of the number of Lewis acid-base interactions appears to be connected with the close-packed array adopted by molecules: distorted cubic close-packed arrays are adopted for alacránite, pararealgar, uzonite, realgar and β-AsS and the distorted hexagonal close-packed arrays adopted by α- and β-dimorphite. A growth mechanism is proposed for thioarsenide molecular crystals from aqueous species that maximizes the number of long range Lewis acid-base vdW As-S bonded interactions with the resulting directed bond paths structuralizing the molecules as a molecular crystal.

  15. A Dual Lewis Base Activation Strategy for Enantioselective Carbene-Catalyzed Annulations

    PubMed Central

    Izquierdo, Javier; Orue, Ane; Scheidt, Karl A.

    2013-01-01

    A dual activation strategy integrating NHC catalysis and a second Lewis base has been developed. NHC-bound homoenolate equivalents derived from α,β-unsaturated aldehydes combine with transient reactive o-quinione methides in an enatioselective formal [4+3] fashion to access 2-benzoxopinones. The overall approach provides a general blueprint for the integration of carbene catalysis with additional Lewis base activations modes. PMID:23829462

  16. Small Molecule Activation by Intermolecular Zr(IV)-Phosphine Frustrated Lewis Pairs.

    PubMed

    Metters, Owen J; Forrest, Sebastian J K; Sparkes, Hazel A; Manners, Ian; Wass, Duncan F

    2016-02-17

    We report intermolecular transition metal frustrated Lewis pairs (FLPs) based on zirconocene aryloxide and phosphine moieties that exhibit a broad range of small molecule activation chemistry that has previously been the preserve of only intramolecular pairs. Reactions with D2, CO2, THF, and PhCCH are reported. By contrast with previous intramolecular examples, these systems allow facile access to a variety of steric and electronic characteristics at the Lewis acidic and Lewis basic components, with the three-step syntheses of 10 new intermolecular transition metal FLPs being reported. Systematic variation to the phosphine Lewis base is used to unravel steric considerations, with the surprising conclusion that phosphines with relatively small Tolman steric parameters not only give highly reactive FLPs but are often seen to have the highest selectivity for the desired product. DOSY NMR spectroscopic studies on these systems reveal for the first time the nature of the Lewis acid/Lewis base interactions in transition metal FLPs of this type. PMID:26788963

  17. Liquid-Phase Catalytic Transfer Hydrogenation of Furfural over Homogeneous Lewis Acid-Ru/C Catalysts.

    PubMed

    Panagiotopoulou, Paraskevi; Martin, Nickolas; Vlachos, Dionisios G

    2015-06-22

    The catalytic performance of homogeneous Lewis acid catalysts and their interaction with Ru/C catalyst are studied in the catalytic transfer hydrogenation of furfural by using 2-propanol as a solvent and hydrogen donor. We find that Lewis acid catalysts hydrogenate the furfural to furfuryl alcohol, which is then etherified with 2-propanol. The catalytic activity is correlated with an empirical scale of Lewis acid strength and exhibits a volcano behavior. Lanthanides are the most active, with DyCl3 giving complete furfural conversion and a 97 % yield of furfuryl alcohol at 180 °C after 3 h. The combination of Lewis acid and Ru/C catalysts results in synergy for the stronger Lewis acid catalysts, with a significant increase in the furfural conversion and methyl furan yield. Optimum results are obtained by using Ru/C combined with VCl3 , AlCl3 , SnCl4 , YbCl3 , and RuCl3 . Our results indicate that the combination of Lewis acid/metal catalysts is a general strategy for performing tandem reactions in the upgrade of furans. PMID:26013846

  18. Current wind tunnel capability and planned improvements at Lewis Research Center

    NASA Technical Reports Server (NTRS)

    Bowditch, D. N.

    1986-01-01

    As the propulsion and power generation center of NASA, Lewis has designed its wind tunnels for propulsion research. Therefore, the 8 by 6 Foot Supersonic Wind Tunnel and the 10 by 10 Foot Supersonic Wind Tunnel provide the capability to test operating propulsion systems from Mach 0.4 to 3.5. The 9 by 15 Foot Wind Tunnel can investigate propulsion installation problems at the lower takeoff and landing speeds and provides an excellent anechoic environment to measure propeller and fan noise. The Lewis Central Air System provides steady air supplies to 450 psi, and exhaust to 3 in. of mercury absolute, which are available to the wind tunnels for simulation of jets and engine induced flows. The Lewis Icing Research Tunnel is the largest in the free world that can produce icing conditions throughout the year. Rehabilitation of the Altitude Wind Tunnel at Lewis would allow testing of propulsion systems in the upper left hand corner which would be a unique capability. Also, in a mothballed state at Lewis, the Hypersonic Tunnel Facility could provide the best simulation of nonvitiated Mach 5-7 test conditions available. Studies are currently being made of the Lewis facilities to identify enhancements of their research potential for the 1990's and beyond.

  19. Thoracoscopic purse string technique for minimally invasive Ivor Lewis esophagectomy

    PubMed Central

    Kang, Ningning; Xia, Wanli; Che, Yun; Wan, Jun; Yu, Zaicheng

    2014-01-01

    Objective Thoracolaparoscopic esophagectomy with chest anastomosis (TLE-chest) is increasingly performed for middle and lower esophageal cancer; however, gastroesophageal anastomosis for this surgery remains both challenging and inefficient. To address this issue, we previously reported our MIE technique with Ivor-Lewis anastomosis. Here we present the video to introduce our TLE-chest operation procedures. Methods TLE-chest with a combined thoracoscopic and laparoscopic technique was performed by one group of surgeons. From October 2011 to September 2013, 80 esophageal cancer patients were treated with TLE-chest using this improved anastomotic technique. Results The surgery was successful for all patients, although the anastomosis in one patient required intraoperative manual repair. No patients required open conversion. In this video, dissociation of stomach, and dissection of lymph nodes, creation of gastric tube and staple line embedding, jejunostomy were carried out by laparoscopic surgery. Dissection of esophageal cancer and mediastinal lymph nodes were done through rib 3 or 4 by a 3-4 cm video-assisted right anterior minithoracotomy, then esophago-gastric anastomosis was performed in right thoracic cavity This video shows the R0 resection of T3N0M0 esophageal cancer. Totally, 36 lymph nodes were dissected, including 21 mediastinal lymph nodes and 15 abdominal lymph nodes. The patient recovered well and was discharged on day 8 after the surgery, with good short term outcomes. Conclusions A safe, cost effective purse string stapled anastomotic technique has been presented for TLE-chest in our video. It is consistent with the oncology principles. PMID:24605229

  20. Properties of Lewis Lung Carcinoma Cells Surviving Curcumin Toxicity

    PubMed Central

    Yan, Dejun; Geusz, Michael E.; Jamasbi, Roudabeh J.

    2012-01-01

    The anti-inflammatory agent curcumin can selectively eliminate malignant rather than normal cells. The present study examined the effects of curcumin on the Lewis lung carcinoma (LLC) cell line and characterized a subpopulation surviving curcumin treatments. Cell density was measured after curcumin was applied at concentrations between 10 and 60 μM for 30 hours. Because of the high cell loss at 60 μM, this dose was chosen to select for surviving cells that were then used to establish a new cell line. The resulting line had approximately 20% slower growth than the original LLC cell line and based on ELISA contained less of two markers, NF-κB and ALDH1A, used to identify more aggressive cancer cells. We also injected cells from the original and surviving lines subcutaneously into syngeneic C57BL/6 mice and monitored tumor development over three weeks and found that the curcumin surviving-line remained tumorigenic. Because curcumin has been reported to kill cancer cells more effectively when administered with light, we examined this as a possible way of enhancing the efficacy of curcumin against LLC cells. When LLC cells were exposed to curcumin and light from a fluorescent lamp source, cell loss caused by 20 μM curcumin was enhanced by about 50%, supporting a therapeutic use of curcumin in combination with white light. This study is the first to characterize a curcumin-surviving subpopulation among lung cancer cells. It shows that curcumin at a high concentration either selects for an intrinsically less aggressive cell subpopulation or generates these cells. The findings further support a role for curcumin as an adjunct to traditional chemical or radiation therapy of lung and other cancers. PMID:22232696