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1

A case report of testicular sparganosis misdiagnosed as testicular tumor.  

PubMed

Sparganosis is a parasitic infestation of human by plerocercoid larvae. Sparganum is usually reported to be found in the subcutaneous tissues as well as other organs, including scrotum. However, testicular sparganosis is extremely rare, because of strong capsule of tunica albuginea. An urban-living 54-yr-old Korean man presented with left scrotal pain for 6 yr. Both testes look normal physically. Ultrasonography revealed poorly defined, heterogeneous mass with increased echogenicity in the left testis. This case was misdiagnosed as testicular tumor and underwent orchiectomy, but was diagnosed as testicular sparganosis by histopathology. Sparganosis should be included for differential diagnosis of testis tumor in countries where sparganosis is prevalent. PMID:25045238

Park, Won Hee; Shin, Tae Young; Yoon, Sang Min; Park, Soo-Hwan; Kang, Yong Jin; Kim, Do Kyung; Han, Jee-Young; Seong, Do Hwan

2014-07-01

2

A Case Report of Testicular Sparganosis Misdiagnosed as Testicular Tumor  

PubMed Central

Sparganosis is a parasitic infestation of human by plerocercoid larvae. Sparganum is usually reported to be found in the subcutaneous tissues as well as other organs, including scrotum. However, testicular sparganosis is extremely rare, because of strong capsule of tunica albuginea. An urban-living 54-yr-old Korean man presented with left scrotal pain for 6 yr. Both testes look normal physically. Ultrasonography revealed poorly defined, heterogeneous mass with increased echogenicity in the left testis. This case was misdiagnosed as testicular tumor and underwent orchiectomy, but was diagnosed as testicular sparganosis by histopathology. Sparganosis should be included for differential diagnosis of testis tumor in countries where sparganosis is prevalent. Graphical Abstract PMID:25045238

2014-01-01

3

Ocular sparganosis from Assam.  

PubMed

Sparganosis is caused by plerocercoid larvae of the Pseudophyllidea tapeworms of the genus Spirometra. Though prevalent in East Asian and south east Asian countries like China, Japan, Korea, Taiwan, Vietnam, Thailand; yet very few cases are reported from India. We report a case of migrating sub-conjunctival ocular sparganosis mimicking scleritis which later on developed into orbital cellulitis from Dibrugarh, Assam, North-eastern part of India. This case is reported for its rarity. PMID:25709957

Nath, Reema; Gogoi, Rajendra Nath

2015-01-01

4

Ocular sparganosis from Assam  

PubMed Central

Sparganosis is caused by plerocercoid larvae of the Pseudophyllidea tapeworms of the genus Spirometra. Though prevalent in East Asian and south east Asian countries like China, Japan, Korea, Taiwan, Vietnam, Thailand; yet very few cases are reported from India. We report a case of migrating sub-conjunctival ocular sparganosis mimicking scleritis which later on developed into orbital cellulitis from Dibrugarh, Assam, North-eastern part of India. This case is reported for its rarity. PMID:25709957

Nath, Reema; Gogoi, Rajendra Nath

2015-01-01

5

Ocular sparganosis mimicking an orbital idiopathic inflammatory syndrome.  

PubMed

Sparganosis is an infection by the parasitic tapeworm larvae of Spirometra species. Ocular sparganosis is a rare disease that is easily misdiagnosed. We reported a rare case of ocular sparganosis mimicking orbital idiopathic inflammatory syndrome at initial presentation. A 34-year-old female presented with rapid progressive swelling of her left eyelid and mild proptosis for the duration of one month. The other ocular examinations were normal and the thyroid function was normal. Magnetic resonance imaging revealed a fusiform enlargement and mild heterogenous enhancement of the superior oblique muscle of the left orbit. First she received prednisolone therapy and the proptosis partially improved. Six months later, a white, flat and wrinkled string like worm wriggled out from the caruncular conjunctiva of the left eye. The pathology results confirmed that the worm was a Spirometra species larva. After removal of the larva and treatment with praziquantel, the proptosis was resolved without recurrence. Ocular sparganosis is a rare disease and only a few case reports have been reported. The drug therapy has not been effective and the surgical removal is the principal therapy. Despite its rarity, ocular sparganosis should be considered as a possible cause of orbital inflammation in patients. PMID:24215169

Ho, Tsai-Hsuan; Lin, Muh-Chiou; Yu, Wei-Wen; Lai, Ping-Hong; Sheu, Shwu-Jiuan; Bee, Youn-Shen

2013-12-01

6

Vulva Anatomy  

MedlinePLUS

... Pictures Browse Search Quick Search Image Details Vulva Anatomy View/Download: Small: 720x634 View Download Add to ... Search | Accessibility | Staff U.S. Department of Health and Human Services | National Institutes of Health | National Cancer Institute | ...

7

Cancer - vulva  

MedlinePLUS

... Jhingran A, Russell AH, Seiden MV, et al. Cancers of the cervix, vulva, and vagina. In: Niederhuber JE, Armitage JO, Doroshow JH, et al., eds. Abeloff's Clinical Oncology . 5th ed. ... Institute: PDQ Vulvar Cancer Treatment. Bethesda, Md: National ...

8

Sparganosis of the breast and lower extremities: sonographic appearance.  

PubMed

Sparganosis is a rare parasitic infection caused by larvae of the genus Spirometra. It can involve any part of the human body and usually manifests as a mass in various locations. We report a case of recurrent sparganosis in the breast and lower extremities. Our patient had recurrent subcutaneous masses in her breast and lower leg that showed characteristic ultrasonographic imaging findings of serpentine, tubular structures with surrounding increased echogenicity. These imaging findings are well correlated with pathologic findings. Worms were identified in resected specimens confirming sparganosis. PMID:24633936

Choi, Seung Joon; Park, Sung Hee; Kim, Min Jung; Jung, Minju; Ko, Byong Ho

2014-09-01

9

Breast sparganosis and incidentally detected subcutaneous and intramuscular sparganosis at several sites: case report and literature review.  

PubMed

Sparganosis is an infestation caused by a tapeworm belonging to the genus Spirometra. We describe a surgically confirmed case of sparganosis in several organs including the breast, both lower extremities, anterior chest wall, inguinal area, and the psoas and gluteus muscles. Mammography, ultrasonography, and MRI imaging findings for our patient were characteristic of sparganosis. Ultrasonography revealed multiple elongated tubular hypoechoic structures with surrounding increased echogenicity. Mammographic findings included tortuous, lobular, and tubular densities. Short tau inversion recovery (STIR) MR images contained several elongated tubular tracts of high signal intensity. These imaging features were highly consistent with pathology results. PMID:25725936

Song, Eun Jee; Sohn, Yu-Mee; Ryu, Kyung Nam; Min, Sun Young; Shin, Sung Hwan; Park, Yong Koo

2015-04-01

10

Angiomyofibroblastoma of the vulva.  

PubMed

Angiomyofibroblastoma (AMFB) is an uncommon benign mesenchymal tumor. AMFB occurs almost in the vulvo-vaginal area of women. The gross features of AMFB are well-circumscribed so it clinically is often thought as Bartholin gland cyst or aggressive angiomyxoma. Usually, most tumors grow slowly, and patients do not feel pain. It also has low tendency for local recurrence. The histologic findings of the tumors are abundant thin-walled blood vessels with hypocellular and hypercellular areas. Almost all tumor cells have immunoreactivity for both desmin and vimentin. It also has estrogen and/or progesterone receptors, but staining for cytokeratin is negative. Here is a case of AMFB of the vulva occurring in a 40-year-old woman, involving the right labia majora. The patient described that her vulva mass grew in about few months. The maximum dimension of the tumor was measured as 2 cm, and we resected the tumor one month after as her second visit. PMID:24328028

Seo, Jung-Won; Lee, Kyoung-A; Yoon, Na-Ra; Lee, Jeong-Won; Kim, Byoung-Gie; Bae, Duk-Soo

2013-09-01

11

Vulva1developmentin Caenorbabditiselegans  

E-print Network

.p P7.p P8.p Wildtype - l-/i?'1%" ,"/a" 1-/L- 1"/2Q,",.a" Multivulva w FicuaE 1. The vulva1 detachfrom ventralcuticle.N, no division.Dotted linesindicateP3p often doesnot diode. (Adaptedfrom Ref. 1.1W by the observations thatvertebratehomologs of sem-5 and mphIcan functionally substitute For the C. e&arts genes

Kornfeld, S. Kerry

12

Aggressive angiomyxoma of the vulva: a précis for primary care providers.  

PubMed

Vulvar aggressive angiomyxoma (AA) is a rare mesenchymal tumor of the vulva. Due to its slow-growing nature, it is often overlooked and misdiagnosed by primary care providers (PCPs). We describe a case report of vulvar AA in a 38-year-old woman who underwent complete surgical excision of the neoplasm with no evidence of recurrence on a 5-year followup. A literature review follows to provide PCPs with the clinical, radiologic, and pathologic features that this tumor displays. PMID:24073346

Elkattah, R; Sarkodie, O; Otteno, H; Fletcher, A

2013-01-01

13

Large Fibroepithelial Polyp of Vulva  

PubMed Central

A rare case of a large fibroepithelial polyp (FEP) of the vulva is described. The polypoidal growth was 10?cm in its largest diameter, having a long pedicle with features of inflammation secondary to infection, and was found arising from the left labia majora. The patient did not manifest any signs of recurrence following excision. A large and infected FEP of the vulva is a rare occurrence and hence reported. PMID:23213577

Navada, Mahesha H.; Bhat, Poornima Ramachandra B.; Rao, Sujaya V.; G., Nagarathna

2011-01-01

14

Axillary sparganosis which was misunderstood lymph node metastasis during neoadjuvant chemotheraphy in a breast cancer patient  

PubMed Central

Sparganosis of the breast is an uncommon disease, but should be considered in the differential diagnosis of unusual and suspicious breast masses. A history of ingesting contaminated water and direct ingestion of snakes and frogs may help in differential diagnosis of the mass. Complete surgical removal is the treatment of choice and provides a definite diagnosis. We report a case of multiple axillary lymph node sparganosis. It was first considered as an axillary metastasis of breast cancer because a newly axillary mass appeared in follow-up radiologic study after neoadjuvant chemotherapy. We performed curative breast cancer surgery and sparganosis was confirmed by extracting the worm during axillary dissection. PMID:25485243

Lee, Eun Kyoung

2014-01-01

15

Misdiagnosed gastrinoma: A case report  

PubMed Central

Gastrinoma is most commonly located in the gastrinoma triangle (comprising of the duodenum, pancreas and bile ducts) or in the adjacent lymph nodes. Due to the low mortality rate, it is often misdiagnosed as other diseases with similar clinical characteristics, such as a solid pseudopapillary tumor of the pancreas (SPTP). Therefore, the current study reports a rare case of gastrinoma located in the tail of the pancreas of a female patient under medical examination, who exhibited no clinical symptoms. The tumor, which was located in the body and tail of the pancreas, was successfully resected and the spleen was preserved. The outcome of surgery combined with the postoperative pathological examination resulted in the patient being misdiagnosed with a SPTP. During the consequent six-year follow-up period, low-density liver lesions and an intractable peptic ulcer gradually appeared. Finally, the patient diagnosis was confirmed as a malignant pancreatic neuroendocrine carcinoma with liver metastases. On June 1, 2011, a liver transplant was successfully performed and the patient has maintained a good overall condition. The underlying clinical and pathological factors that may have resulted in misdiagnosis are investigated in the present study. Through providing our preliminary clinical experiences and lessons, the aim of the present study was to focus the attention of clinicians on this type of cancer in order to improve its diagnosis and treatment. PMID:24932294

SUN, QI-KAI; WANG, WEI; ZHOU, HANG-CHENG; LV, YANG; YU, JI-HAI; MA, JIN-LIANG; JIA, WEI-DONG; XU, GE-LIANG

2014-01-01

16

Primary extraskeletal mesenchymal chondrosarcoma of the vulva  

PubMed Central

Extraskeletal chondrosarcoma is rare, making up only 1% of reported chondrosarcoma. We experienced 3 cases of extraskeletal chondrosarcoma, especially in vulva. They were suspected as lipoma of the vulva. The patients had noticed a small but growing mass on their vulva which had been palpated earlier. The masses were excised with a 2 cm resection margin. The final pathological reports confirmed extraskeletal mesenchymal chondrosarcoma (EMC) of the vulva revealing no microscopic lesions on the resection margins. After 24 months of following from the initial diagnosis, the patients remain without evidence of any recurrent. Management of EMC is not well studied due to the rare and variable nature of the disease. However, the surgery, such as we had, is the mainstay of local treatment with studies showing better survival in patients who undergo wide surgical resection. The establishment of adjuvant systemic pharmacotherapy could be expected in the future. PMID:24328027

Jeh, Eun Ae; Lee, Young Jin; Kim, Ari

2013-01-01

17

Development of a Rapid Diagnostic Kit That Uses an Immunochromatographic Device To Detect Antibodies in Human Sparganosis  

PubMed Central

A diagnostic kit using an immunochromatographic device was developed to replace the time-consuming immunodiagnostic methods for human sparganosis. The kit was found to be faster and easier to use than an enzyme-linked immunosorbent assay (ELISA) and showed higher sensitivity and specificity. It will be useful for the laboratory diagnosis of hospitalized cases of sparganosis. PMID:24990912

Nakamura, Takeshi; Intapan, Pewpan M.; Maleewong, Wanchai; Morishima, Yasuyuki; Sugiyama, Hiromu; Matsuoka, Hiroyuki; Kobayashi, Kaoru; Takayama, Katsuyoshi; Kobayashi, Yukuharu

2014-01-01

18

Primary Langerhans cell histiocytosis of the vulva.  

PubMed

Primary Langerhans cell histiocytosis (LCH) of the female genital tract is very uncommon. Since the natural history of this tumor is unpredictable, with spontaneous remissions and exacerbations, establishment of the diagnosis is often difficult. In the few reported cases of LCH involving the vulva there were systemic manifestations of the disease. We report the clinical and histopathological findings in the case of a 36-year-old woman who presented with a 9-year history of vulvar lesions. The diagnosis of LCH was established by immunohistochemical techniques, which demonstrated sheets of S-100 protein-positive histiocytes in the dermal tumor. The patient received radiotherapy to the vulva and responded with complete remission. PMID:8244196

Voelklein, K; Horny, H P; Marzusch, K; Dietl, J

1993-01-01

19

Nine human sparganosis cases in Thailand with molecular identification of causative parasite species.  

PubMed

Human sparganosis is one of the neglected diseases but important food-borne parasitic zoonoses. The disease is caused by larvae (spargana) of diphyllobothriidean tapeworm. Here, we describe nine cases of human sparganosis, caused by Spirometra erinaceieuropaei in a hospital in Thailand during 2001-2012. Clinical characteristics, treatment, and outcome of cases were revealed. Diagnosis and identification of causative parasite species was made by histopathological investigations followed by a polymerase chain reaction-based molecular method using formalin-fixed paraffin embedded tissues. The DNA samples were extracted from tissues and a partial fragment of cytochrome c oxidase subunit 1 (cox1) gene was amplified for the detection of parasitic DNA. Infection could be prevented by increasing activities on health communication by responsible public health agencies. PMID:24842879

Boonyasiri, Adhiratha; Cheunsuchon, Pornsuk; Suputtamongkol, Yupin; Yamasaki, Hiroshi; Sanpool, Oranuch; Maleewong, Wanchai; Intapan, Pewpan M

2014-08-01

20

Diagnostic efficacy of a recombinant cysteine protease of Spirometra erinacei larvae for serodiagnosis of sparganosis.  

PubMed

The mature domain of a cysteine protease of Spirometra erinacei plerocercoid larva (i.e., sparganum) was expressed in Escherichia coli, and its value as an antigen for the serodiagnosis of sparganosis was investigated. The recombinant protein (rSepCp-1) has the molecular weight of 23.4 kDa, and strongly reacted with the sparganum positive human or mice sera but not with negative sera by immunoblotting. ELISA with rSepCp-1 protein or sparganum crude antigen (SeC) was evaluated for the serodiagnosis of sparganosis using patient's sera. The sensitivity and specificity of ELISA using rSepCp-1 protein were 95.0% (19/20) and 99.1% (111/112), respectively. In contrast, the sensitivity and specificity of ELISA with SeC were 100% (20/20) and 96.4% (108/112), respectively. Moreover, in experimentally infected mice, the sensitivity and specificity of both ELISA assays were 100% for the detection of anti-sparganum IgG. It is suggested that the rSepCp-1 protein-based ELISA could provide a highly sensitive and specific assay for the diagnosis of sparganosis. PMID:24623880

Rahman, S M Mazidur; Kim, Jae-Hwan; Hong, Sung-Tae; Choi, Min-Ho

2014-02-01

21

[Small-cell carcinoma of the vulva].  

PubMed

Small-cell carcinoma is a rare and aggressive malignancy; this tumor is lethal due to the propensity to metastasize early in the course of the disease. It occurs most frequently in the lung. Small-cell cancer also rarely may occur in the female genital tract, usually in the cervix. This article concerns the fifth reported case of small-cell carcinoma of the vulva in a 34-year-old women who had developed a vulvar mass3 months earlier. The physical examination revealed bilateral inguinal lymph nodes. The mass was excised and the histological finding was a small-cell carcinoma. Postoperative search for metastasis included computed tomography scan of the abdomen, pelvis, chest and brain that showed right iliac lymph nodes. The osteo medullar biopsy was positive. The patient was treated with 6 cycles of chemotherapy including cisplatinum (80mg/m2 d1) and etoposide (100mg/m2 d1 d2 d3). Adjuvant radiotherapy (50Gy) was administered but the disease progressed and the patient died after 7 months. Small-cell carcinoma of the vulva is a very rare tumor. Similarly to small-cell cancers arising in other sites, it appears that regional therapy is not a sufficient treatment for this tumor. Chemotherapy should be used to improve outcome. PMID:17151543

Mharrech, A; Benchakroun, N; Tawfiq, N; Jouhadi, H; Acharki, A; Sahraoui, S; Benider, A

2006-12-01

22

Acute vulvar pain in a lady with post circumcision inclusion cyst of the vulva containing stones: a case report  

PubMed Central

Background Despite global eradication efforts, female genital cutting is still deep routed practice in some parts of Asia and East Africa. The crude and unscientific natures of the practice lead to many complications. Epidermoid inclusion cysts of the vulva are one of the late complications of female genital cutting and typically present as painless cystic swellings. But clinical presentation as ‘stone’ containing, hard vulvar mass is reported only once in the literature and presentation with acute vulvar pain has never been documented. Case presentation A 21 yrs old, Ethiopian, unmarried, lady presented with sever acute vulvar pain, discharge, and a stony hard vulvar swelling 13 years after type-III female genital cutting (infibulation). Surgical excision of the cyst, which contained two ‘stones’ inside it, and defibulation were done. Histopathology confirmed calcified, keratinizing epidermoid inclusion cyst of the vulva. Conclusions Clinicians, in areas where female genital cutting is prevalent, should be aware of such unusual late vulvar complication of the practice which might be misdiagnosed for other solid vulvar swellings and be familiar with the appropriate management. PMID:24387298

2014-01-01

23

Evolution of Vulva Development in the Cephalobina (Nematoda)  

Microsoft Academic Search

Ventral cord and vulva development are analyzed in a large sample of nematode species of the suborder Cephalobina. We find a specific range of evolutionary variations at distinct developmental steps. (1) Unlike Caenorhabditis elegans and relatives, the vulva is formed from the four precursor cells P(5–8).p or, exceptionally, from P(6,7).p only. (2) The vulval competence group is restricted to these

Marie-Anne Félix; Paul De Ley; Ralf J. Sommer; Linda Frisse; Steven A. Nadler; W. Kelley Thomas; Jacques Vanfleteren; Paul W. Sternberg

2000-01-01

24

[Histiocytosis X (Langerhans cell granulomatosis) of the vulva].  

PubMed

Isolated histiocytosis X (Langerhans cell granulomatosis) of the vulva is extremely rare. In most reported cases, vulval disease is associated with multitopic organ involvement. We report here on the second case in the world of isolated histiocytosis X of the vulva. The diagnosis could be established by immunohistochemical demonstration of anti-S 100 protein + Langerhans cells. The patient received a local radiation therapy of 10 gy and responded excellently. PMID:8467989

Völklein, K; Horny, H P; Marzusch, K; Dietl, J

1993-03-01

25

Cases of pediatric narcolepsy after misdiagnoses.  

PubMed

Narcolepsy is characterized by recurrent brief attacks of irresistible sleepiness. Signs can begin during childhood. However, diagnoses are frequently delayed by 10-15 years because of unfamiliarity with pediatric narcolepsy and variable presentations of its associated features (cataplexy, hypnagogic/hypnopompic hallucinations, and sleep paralysis). Therefore, patients may remain untreated during their formative years. Three children with narcolepsy who were initially misdiagnosed are described. Each child's signs were initially related to depression, hypothyroidism, jaw dysfunction, or conversion disorder. However, after a multiple sleep latency test, the diagnosis of narcolepsy was established. All three patients were treated appropriately with stimulant medications, selective serotonin reuptake inhibitors, or sodium oxybate, and demonstrated positive responses. Although no definitive cure exists for narcolepsy, early recognition and appropriate symptomatic treatment with medications can allow affected children to improve quality of life and achieve normality, both academically and socially. PMID:23044019

Kauta, Shilpa R; Marcus, Carole L

2012-11-01

26

Autoimmune Lymphoproliferative Syndrome Misdiagnosed as Hemophagocytic Lymphohistiocytosis  

PubMed Central

Autoimmune lymphoproliferative syndrome (ALPS) is a rare inherited disorder of apoptosis, most commonly due to mutations in the FAS (TNFRSF6) gene. It presents with chronic lymphadenopathy, splenomegaly, and symptomatic multilineage cytopenias in an otherwise healthy child. Unfortunately, these clinical findings are also noted in other childhood lymphoproliferative conditions, such as leukemia, lymphoma, and hemophagocytic lymphohistiocytosis, which can confound the diagnosis. This report describes a 6-year-old girl with symptoms misdiagnosed as hemophagocytic lymphohistiocytosis and treated with chemotherapy before the recognition that her symptoms and laboratory values were consistent with a somatic FAS mutation leading to ALPS. This case should alert pediatricians to include ALPS in the differential diagnosis of a child with lymphadenopathy, splenomegaly, and cytopenias; obtain discriminating screening laboratory biomarkers, such as serum vitamin B-12 and ferritin levels; and, in the setting of a highly suspicious clinical scenario for ALPS, pursue testing for somatic FAS mutations when germ-line mutation testing is negative. PMID:24101757

Rudman Spergel, Amanda; Walkovich, Kelly; Price, Susan; Niemela, Julie E.; Wright, Dowain; Fleisher, Thomas A.

2013-01-01

27

Phyllodes tumor of vulva: a brief diagnostic review.  

PubMed

Phyllodes tumors of the vulva are rare proliferations that share morphologic similarities with breast neoplasms. Their histogenetic origin is elusive and may be associated with specialized mammary-like glands of the vulva. Because of their rarity, the clinical and pathologic features, classification, and therapy are not well defined, and their biologic behavior is difficult to predict by histology alone. Immunohistochemical expression of estrogen and progesterone receptors and breast markers provide further support for a common origin. Surgical resection is the current mainstay of therapy and is definitive in most cases. PMID:25357118

Lee, Solomon; Nodit, Laurentia

2014-11-01

28

Comparative study on low back pain misdiagnosed as spondyloarthropathy  

Microsoft Academic Search

This study aims to investigate features of different diseases with low back pain misdiagnosed as spondyloarthropathy so as\\u000a to improve the accuracy of diagnosis for spondyloarthropathy. The clinical and laboratory data of 24 cases misdiagnosed as\\u000a spondyloarthropathy in recent 3 years were comparatively and retrospectively analyzed. The diagnostic accuracy of the European\\u000a Spondyloarthropathy Study Group (ESSG) criteria, Amor criteria, and the

Xiao Li Deng; Xiang Yuan Liu; Ning Xu

2009-01-01

29

Torsion of a Large Appendix Testis Misdiagnosed as Pyocele  

PubMed Central

Torsion of the appendix testis is not an uncommon cause of acute hemiscrotum. It is frequently misdiagnosed as acute epididymitis, orchitis, or torsion of testis. Though conservative management is the treatment of choice for this condition, prompt surgical intervention is warranted when testicular torsion is suspected. We report a case of torsion of a large appendix testis misdiagnosed as pyocele. Emergency exploration of it revealed a large appendix testis with torsion and early features of gangrene. After excision of the appendix testis, the wound was closed with an open drain. The patient had an uneventful and smooth postoperative recovery.

Meher, Susanta; Rath, Satyajit; Sharma, Rakesh; Sasmal, Prakash Kumar; Mishra, Tushar Subhadarshan

2015-01-01

30

Management of radionecrosis of the vulva and distal vagina  

SciTech Connect

Twelve patients were seen between January 1983 and June 1989 with the clinical diagnosis of radionecrosis of the vulva or distal vagina. Seven patients received radiation for vulvar cancer, three for distal vaginal cancer, and two for recurrent endometrial cancer. No patient healed spontaneously and the mean delay in surgical therapy was 8.5 months. The radionecrotic site was treated with local therapy, radical local excision (with or without colostomy), or exenteration. The operative defect was closed primarily in three patients and covered with local flaps or myocutaneous flaps in seven patients. The two patients with local care still have radionecrotic ulcers. One of three patients who were closed primarily continues to have an ulcer. All other patients have healed satisfactorily except one who died after two attempts to correct the problem. Radionecrosis of the vulva and distal vagina should generally be treated surgically.

Roberts, W.S.; Hoffman, M.S.; LaPolla, J.P.; Ruas, E.; Fiorica, J.V.; Cavanagh, D. (Univ. of South Florida, Tampa (USA))

1991-05-01

31

Primitive neuroectodermal tumor originating in the vulva: A case report  

PubMed Central

Primitive neuroectodermal tumors (PNETs) exhibit chromosomal translocations in common with those of Ewing’s sarcoma. They usually originate in bone or soft tissue but rarely arise in the vulva. The current case report presents a case of PNET originating in the vulva in a 60-year-old female, who previously underwent enucleation of a vulvar tumor in another hospital. The pathologist suspected a histopathological diagnosis of PNET, and simple vulvectomy and resection of the inguinal lymph nodes were performed. An ~3 cm mass recurred in the right side of the vulva four years following the initial surgery and the tumor was excised. The tumor comprised small, round-to-oval nuclei and stained positively for MIC-2, synaptophysin, neuron-specific enolase and neurofilament antibodies. To date, the patient remains alive and with no evidence of disease four years following multidisciplinary treatment, despite PNETs usually exhibiting a poor prognosis. This is due to the small tumor size and the absence of distant metastasis. PMID:24959242

MATSUDA, MAKIKO; ICHIMURA, TOMOYUKI; KASAI, MARI; MURAKAMI, MAKOTO; HOSHI, MANABU; KAWAMURA, NAOKI; SUMI, TOSHIYUKI

2014-01-01

32

Primitive neuroectodermal tumor originating in the vulva: A case report.  

PubMed

Primitive neuroectodermal tumors (PNETs) exhibit chromosomal translocations in common with those of Ewing's sarcoma. They usually originate in bone or soft tissue but rarely arise in the vulva. The current case report presents a case of PNET originating in the vulva in a 60-year-old female, who previously underwent enucleation of a vulvar tumor in another hospital. The pathologist suspected a histopathological diagnosis of PNET, and simple vulvectomy and resection of the inguinal lymph nodes were performed. An ~3 cm mass recurred in the right side of the vulva four years following the initial surgery and the tumor was excised. The tumor comprised small, round-to-oval nuclei and stained positively for MIC-2, synaptophysin, neuron-specific enolase and neurofilament antibodies. To date, the patient remains alive and with no evidence of disease four years following multidisciplinary treatment, despite PNETs usually exhibiting a poor prognosis. This is due to the small tumor size and the absence of distant metastasis. PMID:24959242

Matsuda, Makiko; Ichimura, Tomoyuki; Kasai, Mari; Murakami, Makoto; Hoshi, Manabu; Kawamura, Naoki; Sumi, Toshiyuki

2014-07-01

33

Pigmented Mammary Paget Disease Misdiagnosed as Malignant Melanoma  

PubMed Central

Pigmented mammary Paget disease is a very rare clinicopathologic variant of mammary Paget disease. Diagnosis is often difficult because its clinical and histological features are very similar to those of malignant melanoma. Herein, we report a case of pigmented mammary Paget disease misdiagnosed as malignant melanoma. PMID:25473229

Lee, Ji Hye; Kim, Tae Hyung; Kim, Soo-Chan; Kim, You Chan

2014-01-01

34

Photodynamic Therapy for Bowen's Disease of the Vulva Area  

PubMed Central

Bowen's disease is a squamous cell carcinoma in situ and has the potential to progress to a squamous cell carcinoma. The authors treated two female patients (a 39-year-old and a 41-year-old) with Bowen's disease in the vulva area using topical photodynamic therapy (PDT), involving the use of 5-aminolaevulinic acid and a light-emitting diode device. The light was administered at an intensity of 80 mW/cm2 for a dose of 120 J/cm2 biweekly for 6 cycles. The 39-year-old patient showed excellent clinical improvement, but the other patient achieved only a partial response. Even though one patient underwent a total excision 1 year later due to recurrence, both patients were satisfied with the cosmetic outcomes of this therapy and the partial improvement over time. The common side effect of PDT was a stinging sensation. PDT provides a relatively effective and useful alternative treatment for Bowen's disease in the vulva area. PMID:24882981

Kang, Hong-Kyu; Yun, Jeong-Hwan; Son, Young-Min; Roh, Joo-Young

2014-01-01

35

Ulcus vulvae acutum Lipschütz in two young female patients.  

PubMed

Ulcus vulvae acutum Lipschütz or acute genital ulcer is a distinct clinical entity characterized by sudden painful genital ulceration occurring mostly in young and virgin girls with malaise, fever and other systemic symptoms. This distressing syndrome is rare and may be presented to dermatologists, gynecologists or pediatricians. Its diagnosis and therapy can be challenging. We present two young female patients with ulcus vulvae acutum. The cause of the disease could not be confirmed in our patients, but, interestingly, both patients had partial IgA deficiency. In the last 100 years, after its first description by Lipschütz, many case reports and series have aimed to identify a specific cause of the disease, without success. These studies mainly focused on infectious agents as causative factors, however, in most cases connection with infection could not be confirmed. Our opinion is that the decreased level of IgA could be a possible explanation for the cause of this syndrome. With our cases we would like to emphasize the possible role of local immunological mechanisms rather than several infectious agents in the development of this little-known disease. PMID:24721611

Kinyó, Ágnes; Nagy, Nikoletta; Oláh, Judit; Kemény, Lajos; Bata-Csörg?, Zsuzsanna

2014-01-01

36

Sentinel lymph node mapping of a breast cancer of the vulva: Case report and literature review  

PubMed Central

Ectopic breast tissue is rare and typically presents as an axillary mass. Previous reports have identified ectopic breast tissue in the vulva, but malignancy is exceedingly uncommon. We present a 62 years old with locally advanced breast carcinoma arising in the vulva demonstrates the utilization of sentinel lymph node mapping to identify metastatic lymph nodes previously unable to be identified via traditional surgical exploration. Our case supports the principles of adjuvant therapy for breast cancer to be applied to ectopic breast cancer arising in the vulva. A literature review highlights common key points in similar cases to guide management. PMID:25866706

Cripe, James; Eskander, Ramez; Tewari, Krishnansu

2015-01-01

37

Angiomyofibroblastoma of the vulva: a clinicopathological and immunohistochemical analysis of a rare benign mesenchymal tumor.  

PubMed

Angiomyofibroblastoma is a rare benign distinctive mesenchymal tumor that occurs in the genital pelviperineal region, commonly the vulva and vagina. We report a case of angiomyofibroblastoma in a 42-year-old woman, presenting as a "cystic mass" located subcutaneously in the right labial area of the vulva. Recognition of this entity is based on specific histological and immunopathological features, and the correct treatment is important because of the aggressive behavior of other related mesenchymal tumors of the vulva and vagina, such as angiomyxoma and cellular angiofibroma. PMID:21797135

Kairi-Vassilatou, E; Dastamani, C; Vouza, E; Mavrigiannaki, P; Hasiakos, D; Kondi-Pafiti, A

2011-01-01

38

The Endemic Mimic: Blastomycosis An Illness Often Misdiagnosed  

PubMed Central

One of the endemic fungi, Blastomyces dermatitidis, can cause epidemics of infection with multiple persons involved in a point source outbreak but more commonly causes sporadic cases of infection within the areas of endemicity. Blastomycosis can present as an acute pneumonia which is often misdiagnosed as acute pneumococcal pneumonia or the infection may present as a chronic pneumonia along with weight loss, night sweats, hemoptysis, and a lung mass suggesting tuberculosis or carcinoma of the lung. Extrapulmonary infection with B. dermatitidis is protean with many different manifestations. Most commonly, skin or subcutaneous lesions are found with either a verrucous or warty appearance or in an ulcerative form. Cases have been misidentified as keratoacanthoma, pyoderma gangrenosum, carcinoma, or as Weber-Christian panniculitis if there are nodular subcutaneous lesions. Essentially any site or organ can have lesions of disseminated blastomycosis. In our series, cases of laryngeal carcinoma, adrenal insufficiency, thyroid nodules, granulomatous hypercalcemia, abnormal mammograms thought to represent breast carcinoma, otitis media with cranial extension, immune thrombocytopenic purpura, and hemolytic anemia of unknown cause have been misdiagnosed and blastomycosis subsequently identified as the cause. This infection causes manifestations which mimic many other more commonly diagnosed conditions and must always be considered by clinicians practicing in the endemic region. PMID:25125734

Bradsher, Robert W.

2014-01-01

39

Keratocystic odontogenic tumour (KCOT) misdiagnosed as a dentigerous cyst  

PubMed Central

Keratocystic odontogenic tumours are known for their peculiar behaviour, varied origin, debated development, unique tendency to recur and disputed treatment modalities. Thus, it has been the subject of much research over the last 40?years. It was formerly known as odontogenic keratocyst (OKC). OKC received its new title as keratocystic odontogenic tumour (KCOT) by the WHO (2005) in order to suggest its aggressive and recurrent nature. KCOT is a benign intraosseous neoplasm of the jaw. Involvement of the maxillary sinus is an unusual presentation. We present the case of an 11-year-old child with extensive KCOT and an impacted canine in the right maxillary sinus. The cyst was initially misdiagnosed to be a dentigerous cyst based on the clinical and radiographic features though a differential diagnosis of KCOT and adenomatoid odontogenic tumour was made. The histological examination of the specimen finally confirmed it to be a KCOT. The clinical, radiological and histological features of this tumour along with its surgical management have been discussed. PMID:23429028

Chaudhary, Seema; Sinha, Ashish; Barua, Pranamee; Mallikarjuna, Rachappa

2013-01-01

40

Aggressive angiomyxoma of vulva and vagina: a series of three cases and review of literature  

Microsoft Academic Search

Background  Aggressive angiomyxoma is a rare locally aggressive mesenchymal tumor of unknown etiology usually affecting the vulva, perianal\\u000a region, buttocks or pelvis of reproductive age women.\\u000a \\u000a \\u000a \\u000a \\u000a Material  A series of three cases, one each of vaginal, vulval and labial angiomyxoma is being presented. The etiology, presentation,\\u000a diagnosis and management of this rare genital tumor are outlined.\\u000a \\u000a \\u000a \\u000a \\u000a Conclusion  Angiomyxoma of vulva and vagina refers

Krishna Dahiya; Shaveta Jain; Nirmala Duhan; Smiti Nanda; Parveen Kundu

2011-01-01

41

Mammary-like adenocarcinoma of the vulva associated to Paget's disease: a case report  

PubMed Central

Mammary-like adenocarcinoma of the vulva associated to Paget's disease is exceedingly rare. So, it is very important to perform all the pathological and immunohistochemical investigations to achieve differential diagnosis from both a metastatic lesion from an orthotopic breast cancer and a vulvar adnexal tumor. This report describes a case of vulvar Paget's disease associated with underlying mammary-like adenocarcinoma diagnosed in the Department of Obstetrics and Gynecology of Farhat Hached university hospital of Sousse in Tunisia. We also review previously reported cases of primary breast-like carcinoma of the vulva with or without Paget's disease.

Meddeb, Sawsen; Rhim, Mohamed Salah; Mestiri, Sarra; Kouira, Mouna; Bibi, Mohamed; Khairi, Hedi; Yacoubi, Mohamed Tahar

2014-01-01

42

Embryology and anatomy of the vulva: the female orgasm and women's sexual health  

Microsoft Academic Search

Sexual health is vital to overall well-being. Orgasm is a normal psycho-physiological function of human beings and every woman has the right to feel sexual pleasure. The anatomy of the vulva and of the female erectile organs (trigger of orgasm) is described in human anatomy textbooks. Female sexual physiology was first described in Dickinson's textbook in 1949 and subsequently by

Vincenzo Puppo

2011-01-01

43

Severe infection of wild-caught snakes with Spirometra erinaceieuropaei from food markets in Guangzhou, China involves a risk for zoonotic sparganosis.  

PubMed

Wild-caught snakes are a popular and traditional food in China. However, little known to the public, snakes are also intermediate hosts of Spirometra erinaceieuropaei, a food- and water-borne pathogen of sparganosis. Therefore, we investigated the prevalence of S. erinaceieuropaei in 10 popular species of wild-caught snakes in Guangzhou City (Guangdong Province) between July 2009 and July 2010. One hundred and twenty-four specimens of 10 species (including Enhydris plumbea, Zoacys dhumnades, Elaphe radiate, Elaphe taeniura, Elaphe carinata, Ptyas mucosus, Ptyas korros, Naja naja atra, Bungarus fasciatus, and Bungarus multicinctus) were randomly selected from a total of 1,160 wild-caught snakes. They were obtained from food markets in 5 representative districts (Huadou, Panyu, Tianhe, Haizhu, and Conghua). The specimens were killed, necropsied, and examined for parasitic helminths. Of the snakes examined, 29.8% were infected by spargana and the worm burden per infected snake ranged from 1 to 221. Most species were infected except for En. plumbea, B. fasciatus, and B. multicinctus. Prevalence even reached 100% in Zoacys dhumnades. More than half (53.5%) of the spargana were located in muscular tissue, 36.4% in subcutaneous tissue, and 10.1% in the coelomic cavity. The study revealed the potential risk for the zoonotic sparganosis by eating wild-caught snakes and will be helpful in arousing public health concern about the consumption of snake meat. PMID:21348631

Wang, Fumin; Zhou, Lihua; Gong, Shiping; Deng, Yanzhong; Zou, Jiejian; Wu, Jun; Liu, Wenhua; Hou, Fanghui

2011-02-01

44

Magnetic resonance imaging findings of fibroepithelial polyp of the vulva: radiological-pathological correlation.  

PubMed

We describe the magnetic resonance (MR) imaging findings in a 20-year-old woman with a fibroepithelial polyp of the vulva. Within the lesion, abundant fibrous tissue was visualized as stratiform hypointense areas on T2-weighted magnetic resonance imaging (MRI) scans. At the center of the attachment site, clustered fatty tissue was revealed as linear hyperintense areas on T1-weighted MRI. A mild degree of edematous stroma including less fibrosis and cellularity was demonstrated as hyperintense areas on T2-weighted MRI and hypointense areas on T1-weighted MRI. Although the MRI findings of fibroepithelial polyps of the vulva are often similar to those of aggressive angiomyxoma, angiomyofibroblastoma, and cellular angiofibroma, a fibroepithelial polyp should be considered when radiological images demonstrate the following features: stratiform hypointense areas surrounded by patchy hyperintense areas on T2-weighted MRI and hyperintense areas on T1-weighted MRI. PMID:20972861

Kato, Hiroki; Kanematsu, Masayuki; Sato, Eriko; Ito, Naoki; Furui, Tatsuro; Hirose, Yoshinobu

2010-10-01

45

Metachronous metastasis from the right colon adenocarcinoma to the vulva: an unusual report and literature review  

PubMed Central

A 67-year-old woman who was presented to the gynecologist with a two-month history of heavy vaginal bleeding, after an excisional biopsy of vulvar mass, was diagnosed with the right colon adenocarcinoma metachronous metastasis to the vulva. Pathological examination preliminarily revealed by primary adenosquamous carcinoma of vulva. The original submitting pathologist and gynecologist were contacted to obtain the pathological and clinical information whenever possible, combining with a history of the right colon cancer, subsequently, which confirmed the diagnosis of vulvar metastatic adenocarcinoma. Distinguishing metastatic carcinoma from primary vulvar adenocarcinoma is crucial, since these carcinomas are different. Herein reports the second case of the right colon carcinoma presenting as a vulvar metastasis. This report also shows the differentiation, diagnosis and treatment of metastatic colon carcinoma and its metastatic route. PMID:25755809

Ren, Kexing; Ma, Xuelei; Wang, Feng; Guo, Fuchun; Jiang, Yu; Liu, Lei

2015-01-01

46

Two cases of tracheal disease misdiagnosed as difficult-to-treat asthma.  

PubMed

Initial management of patients with difficult-to-treat asthma must begin with confirmation of the diagnosis. We present 2 cases of tracheal disease misdiagnosed as difficult-to-treat asthma. After systemic evaluation, tracheomalacia and tracheobronchial narrowing due to diffuse calcification of the cartilaginous rings were found as mimicking asthma. PMID:23431310

Alici, Ibrahim Onur; Kar Kurt, Ozlem; Dursun, Adile Berna; Yilmaz, Aydin; Erkekol, Ferda Oner

2013-11-01

47

Intraosseous Hemangioma of the Middle Turbinate Misdiagnosed As a Nasal Polyp  

PubMed Central

Intraosseous hemangiomas account for 1% of all bone tumors and primarily originate from the vertebral column and skull bones. However, intraosseous hemangiomas of the nasal cavity are extremely rare. Here, we report a case of intraosseous hemangioma with a cavernous pattern arising from the middle turbinate that was preoperatively misdiagnosed as chronic rhinosinusitis with polyps. Except for nasal obstruction, there were no specific rhinologic symptoms. The tumor was excised en bloc by the endoscopic endonasal approach without preoperative embolization. PMID:25165592

Lim, Eun Jung; Lee, Jin Gul; Han, Man-Hoon

2014-01-01

48

An exceptional combined malformation: duplication of the urinary and intestinal tracts and the vulva (04-80CR)  

Microsoft Academic Search

The authors reported the surgical treatment of a 2-year-old girl with complete duplication of the kidney, ureter, bladder, urethra, and the vulva, associated with intestinal duplication and complete duplication of the appendix and colon. Congenital intestinal malrotation also concurred. After a series of preoperative examinations, exploratory operation including reduction of intestinal malrotation, fusion of bladder and colon, obliteration of the

Li Jianhong; Jiang Xuewu; Hu Xianliang

2005-01-01

49

Safety and efficacy of locally applied imiquimod cream 5% for the treatment of condylomata acuminata of the vulva  

Microsoft Academic Search

Aim The aim of the present study was to assess the efficacy and safety of local application of imiquimod cream 5% for managing condylomata acuminata of the vulva in women referred to a tertiary University Hospital centre. Method From a total of 283 patients referred over a 3-year period, 73(26%) were treated with imiquimod. Results Approximately 6% failed to continue

Dimitrios Haidopoulos; Emmanuel Diakomanolis; Alexandros Rodolakis; George Vlachos; Alexandros Elsheikh; Stylianos Michalas

2004-01-01

50

Sentinel Lymph Node Identification with Technetium99m-Labeled Nanocolloid in Squamous Cell Cancer of the Vulva  

Microsoft Academic Search

In patients with early-stage squamous cell cancer of the vulva, inguinofemoral lymphadenectomy is performed primarily as a diag nostic procedure. The morbidity of this procedure, however, is not negligible. The aim of this study was to evaluate the feasibility of minimally invasive detection of the sentinel inguinofemoral lymph node (SILN) and to investigate whether the histopathology of the SILNs is

Joanne A. de Hullu; Edwina Doting; Do A. Piers; Harrie Hollema; Jan G. Aalders; Schraffordt Koops; Henk Boonstra

51

Cholecystocolic fistula caused by gallbladder carcinoma: Preoperatively misdiagnosed as hepatic colon carcinoma  

PubMed Central

Cholecystocolic fistula secondary to gallbladder carcinoma is extremely rare and has been reported in very few studies. Most cholecystocolic fistulae are late complications of gallstone disease, but can also develop following carcinoma of the gallbladder when the necrotic tumor penetrates into the adjacent colon. Although no currently available imaging technique has shown great accuracy in recognizing cholecystocolic fistula, abdominopelvic computed tomography may show fistulous communication and anatomical details. Herein we report an unusual case of cholecystocolic fistula caused by gallbladder carcinoma, which was preoperatively misdiagnosed as hepatic flexure colon carcinoma.

Ha, Gi Won; Lee, Min Ro; Kim, Jong Hun

2015-01-01

52

Mucocele of the vermiform appendix misdiagnosed as an adnexal mass on transvaginal sonography.  

PubMed

Mucocele of the vermiform appendix is a rare entity that may mimic a right-sided adnexal mass. We describe a case of appendiceal mucocele in a 78-year-old woman that was initially misdiagnosed as a potentially malignant right ovarian tumor and briefly review the literature on sonographic features of this entity. It is important to improve preoperative diagnosis so as to prevent rupture of mucocele at surgery, which may lead to pseudomyxoma peritonei, and also to seek intraoperatively for the presence of synchronous colorectal neoplasms. PMID:21739436

Papoutsis, Dimitrios; Protopappas, Athanasios; Belitsos, Panagiotis; Sotiropoulou, Maria; Antonakou, Angeliki; Loutradis, Dimitrios; Antsaklis, Aris

2012-10-01

53

Arteriovenous fistula of the filum terminale misdiagnosed and previously operated as lower lumbar degenerative disease.  

PubMed

Filum terminale arteriovenous fistula (FTAVF) presenting as a cause of failed back surgery syndrome is a rare entity. We report a 48-year-old male patient who presented with clinical features of a conus medullaris/cauda equina lesion. He had upper and lower motor neuron signs in both the lower limbs with autonomic dysfunction. The patient was misdiagnosed and was operated twice earlier for lumbar canal stenosis and disc prolapse. After reviewing his clinical and radiological findings a diagnosis of FTAVF was made. He underwent surgery and there was a significant improvement in his neurological functions. We discuss the case and review the literature on FTAVF's. PMID:24967053

Sharma, Pankaj; Ranjan, Alok; Lath, Rahul

2014-06-01

54

Aggressive angiomyxoma of the vulva in a patient with systemic lupus erythematosus.  

PubMed

Aggressive angiomyxoma is a rare, slow-growing mesenchymal neoplasm with a tendency to recur. It mainly involves the pelvis, vulva, perineum, vagina, and urinary bladder in adult women of reproductive age group. We describe a 26-year-old female with large swellings of both labia majora which was histologically diagnosed as aggressive angiomyxoma. She also had systemic lupus erythematosus. The swelling was surgically removed and she had no recurrence at 1-year follow-up. Although it is a rare tumor, it must be considered as a differential diagnosis for any mass in the perineum or soft tissue of the pelvis. Long-term follow-up is necessary for early diagnosis of local recurrence. PMID:22565439

Pahwa, P; Khaitan, B K; Rao, A; Kriplani, A; Mahey, R; Subbarao, K C

2012-01-01

55

Dopa-responsive dystonia with a novel initiation codon mutation in the GCH1 gene misdiagnosed as cerebral palsy.  

PubMed

Dopa-responsive dystonia (DRD) is a clinical syndrome characterized by childhood-onset dystonia and a dramatic response to relatively low doses of levodopa. However, patients with DRD can be misdiagnosed as cerebral palsy or spastic diplegia due to phenotypic variation. Here we report a young woman with DRD who were severely disabled and misdiagnosed as cerebral palsy for over 10 yr. A small dose of levodopa restored wheelchair-bound state to normality. However, thoracolumbar scoliosis has remained as a sequel due to late detection of DRD. Genetic analysis by using PCR-direct sequencing revealed a novel initiation codon mutation (c.1A>T; p.Met1Leu) in GTP cyclohydrolase 1 (GCH1) gene. Although it is known that DRD can be misdiagnosed as cerebral palsy, this case reinforces the importance of differential diagnosis of DRD from cerebral palsy. PMID:21935284

Lee, Jae-Hyeok; Ki, Chang-Seok; Kim, Dae-Seong; Cho, Jae-Wook; Park, Kyung-Phil; Kim, Seonhye

2011-09-01

56

Pseudodyssynergia (Contraction of the External Sphincter During Voiding) Misdiagnosed as Chronic Nonbacterial Prostatitis and the Role of Biofeedback as a Therapeutic Option  

Microsoft Academic Search

PurposeChronic lower urinary tract symptoms in young men are often attributed to misdiagnosed chronic nonbacterial prostatitis. We analyzed contraction of the external urinary sphincter during voiding (pseudodyssynergia) as an etiology of voiding dysfunction in men with misdiagnosed chronic prostatitis.

Steven A. Kaplan; Richard P. Santarosa; Patricia Meade D'Alisera; Brenda J. Fay; Edward F. Ikeguchi; James Hendricks; Lonnie Klein; Alexis E. Te

1997-01-01

57

Swyer-James-MacLeod syndrome; repeated chest drainages in a patient misdiagnosed with pneumothorax.  

PubMed

Swyer-James-MacLeod Syndrome (SJMS) occurs as a result of childhood bronchiolitis obliterans. Typically, this disorder is diagnosed in childhood after evaluations for recurrent respiratory infections. One of the reasons to explain the difficulty in diagnosis is that when patients develop little bronchiectasis, and therefore, few symptoms, then this syndrome may not be recognized until adulthood. Here, we are presenting a 22-year-old female patient who was diagnosed with SJMS who was initially misdiagnosed with a pneumothorax and treated by multiple chest tube drainages. This case highlights the significance of taking a careful history, the application of computed tomography and scintigraphy in confirming the diagnosis of SJMS and in eliminating other diseases. PMID:19164309

Sulaiman, Abdulrazzaq; Cavaille, Alaric; Vaunois, Brigitte; Tiffet, Olivier

2009-04-01

58

[A case of iatrogenic ilio-iliac arteriovenous fistula initially misdiagnosed as deep venous thrombosis].  

PubMed

Iliac arteriovenous fistula (AVF) usually manifests in a wide range of symptoms similar to typical deep venous thrombosis (DVT), which often lead to delayed diagnosis or misdiagnosis. We reported a 51-year old woman who was performed lumbar discectomy and showed a progressive abdominal distention, dyspnea, and swollen left leg. She was initially diagnosed as deep vein thrombosis and the fi nal diagnosis was arteriovenous fistula. Th e fistula was successfully sealed by an endovascular covered stent. No further recurrence was found aft er a half year's follow-up. Th is article summarized the experience regarding iliac arteriovenous fistula misdiagnosed, and discussed the differential diagnosis between arteriovenous fistula and pulmonary thromboembolism caused by deep vein thrombosis. PMID:25432380

Li, Yan; Fu, Qiang; Liu, Aizhong; Zheng, Zhaofen; Fan, Wenjuan; Zhu, Zhenhua; Chen, Long; Dai, Wenjie

2014-11-01

59

Robotic-Assisted Surgery Approach in a Biliary Rhabdomyosarcoma Misdiagnosed as Choledochal Cyst  

PubMed Central

Rhabdomyosarcoma is a soft tissue malignant tumor affecting 1% of children from 0 to 14 years. Preoperative imaging may not always be diagnostic for hepatobiliary rhabdomyosarcoma and differential diagnosis with choledochal cyst (CC) could be difficult. We report a case of 2-years-old girl with a strange CC pattern of presentation. A grapelike lesion involving the choledochal and biliary ducts was easily and completely resected by robotic assisted surgery. Since no previous reports were available about oncologic safety of robotic approach, the porto-enterostomy was performed in open surgery. On histologic examination, the specimen revealed a botryoidembryonal rhabdomyosarcoma affecting both the common bile duct and the common hepatic duct. One year postoperatively the child is safe of tumor relapse. Robotic approach seems to be safe and advantageous to obtain a radical excision of the tumor at the porta hepatis, even in case of misdiagnosed malignant lesion mimicking a CC. PMID:24711907

Nakib, Ghassan; Calcaterra, Valeria; Goruppi, Ilaria; Romano, Piero; Raffaele, Alessandro; Schleef, Jurgen; Pelizzo, Gloria

2014-01-01

60

Staphylococcus pseudintermedius can be misdiagnosed as Staphylococcus aureus in humans with dog bite wounds.  

PubMed

The purpose of this study was to investigate whether S. pseudintermedius is misdiagnosed as S. aureus by clinical laboratories when isolated from humans with dog bite wounds. In addition, we attempted to determine whether S. pseudintermedius isolates related to dog bite wounds share phenotypic and genotypic traits. S. pseudintermedius was identified by PCR targeting the nuc gene. Isolates were tested for antibiotic susceptibility using VetMIC GP-mo microdilution panels. The occurrence of genes encoding leukocidins, exfoliatins, pyrogenic toxin superantigens and enterotoxins was determined by PCR. The relatedness of S. pseudintermedius isolates was investigated using Multi Locus Sequence Typing (MLST). Out of 101 isolates defined as S. aureus by human clinical microbiology laboratories, 13 isolates were re-identified as S. pseudintermedius and one isolate was confirmed to carry the mecA gene, i.e. methicillin-resistant (MRSP). The MRSP isolate was also defined as multi-resistant. Two methicillin-susceptible S. pseudintermedius isolates were also multi-resistant and five were susceptible to all antibiotics tested. With the exception of three S. pseudintermedius isolates belonging to multi locus sequence type (MLST) 158, all the isolates belonged to unique STs. All isolates contained lukS/F-I, siet and se-int, and expA were identified in two isolates and expB and sec canine-sel in one isolate respectively. S. pseudintermedius is frequently misdiagnosed as S. aureus from humans with dog bite wounds showing that it can act as an opportunistic pathogen in humans. No common phenotypic and genotypic traits shared by the S. pseudintermedius isolates could be identified. PMID:25532507

Börjesson, S; Gómez-Sanz, E; Ekström, K; Torres, C; Grönlund, U

2015-04-01

61

Metastatic vertebral tumor misdiagnosed in magnetic resonance imaging as benign degenerative bone marrow changes: a case report  

Microsoft Academic Search

Many disorders including congenital, degenerative, inflammatory, and neoplastic lesions are associated with low back pain. It is essential to differentiate between malignant disease and the more common causes of back pain. We report a man with low back and right groin pain as a result of metastatic breast carcinoma which was misdiagnosed in magnetic resonance imaging as benign degenerative changes.

Burcu Yan?k; Birkan Sonel Tur; ?ehim Kutlay

2005-01-01

62

Psychosexual functioning after the treatment of cancer of the vulva. A longitudinal study.  

PubMed

Ten couples, the women beginning treatment for carcinoma of the vulva, participated in a 2-year longitudinal study on sexual functioning before and after treatment. Sexual functioning was measured on admission and at 6, 12, and 24 months posttreatment. Sexual functioning was made operational in terms of current sexual behavior, sexual motivation, sexual (dis)satisfaction, and the perception of genital sensations of sexual arousal. An age-matched nonpatient control group was added to the study and the impact of physical variables was also evaluated. Within 1 year, all women who were sexually active before the treatment had resumed their sexual activities. At the 6-month assessment an increase in relational sexual dissatisfaction could be detected. Over the remaining observation period the women's satisfaction with sexual interaction with the partner was not found to be different from their pretreatment satisfaction and not different from the satisfaction in the control group, in spite of the physical damage and persisting poor perception of genital symptoms of sexual arousal during lovemaking. Satisfaction with sexual interaction with the partner under these circumstances appears to be more an expression of satisfaction with the intimate aspects of the sexual relationship than of satisfaction with the physiologic arousal aspects of the sexual relationship. It is argued that psychological and social variables are more crucial for sexual rehabilitation than physical variables. Therefore, psychosocial issues constitute the most promising focus for intervention. PMID:2369721

Weijmar Schultz, W C; van de Wiel, H B; Bouma, J; Janssens, J; Littlewood, J

1990-07-15

63

Oncogenic viruses associated with vulva cancer in HIV-1 patients in Botswana  

PubMed Central

Background Oncoviruses such as HPV, KSHV, and EBV have been reported in patients with HIV infection and AIDS. How oncovirus-associated cancers rise in AIDS patients has not been fully established. The purpose of our study was to identify the viral agents in vulvar cancer and to assess their contribution to pathogenesis. Method We retrospectively identified a total of 13 vulva tissue samples from HIV-1 positive and 9 vulvar samples from HIV-1 negative patients from the Botswana National Health Laboratory in Gaborone, Botswana, a Southern African country with a high incidence of HIV. We utilized PCR and IHC to identify HPV, EBV, KSHV, and JC virus in FFPE preserved tissue samples. Results Using the GP5+/GP6+ primer set we detected several HPV types in tissue samples. EBV was detected in all of the positive cases (100%) and in most of the negative cases (89%). KSHV was detected in 39% of the HIV-1 positive samples and in 11% of the negative samples, and no JC virus was detected in any of the samples. Using IHC we demonstrated that LANA was expressed in 61% of the positive samples and in 44% of the negative samples. The ubiquitous EBV was more consistently expressed in negative cases (100%) than in positive cases (69%). Interestingly, the HPV-16 E6 transcript was detected in 56% of the negative samples compared to 31% of the positive samples. However, the cell cycle protein P21 used as a surrogate marker for HPV was detected in 77% of the positive samples and in 44% of the negative samples, while VEGF signals were similar in both positive (92%) and negative samples (89%). Conclusion Our study, suggests that in Botswana, vulvar squamous cell carcinoma (VSCC) is associated with oncogenic viruses present in the niche but the contribution and progression may be regulated by HPV and other immunosuppressive infections that include HIV-1. PMID:25225572

2014-01-01

64

Localized amyloidosis of the vulva with and without vulvar intraepithelial neoplasia: report of a series.  

PubMed

Localized primary cutaneous amyloidosis is uncommon in Europe and North America and is infrequently reported in the English literature. The constituents of such deposits have not been previously examined; this series characterizes amyloid deposits in localized vulvar amyloidosis and their association with vulvar intraepithelial neoplasia. All biopsies and excisions of vulva over 18 months were reviewed. Cases with suspected amyloidosis were retrieved after institutional review board approval. Twenty cases mimicking amyloidosis were selected as controls. All study and control cases were stained with Congo red. Four Congo red-positive study cases were studied by liquid chromatography-tandem mass spectrometry. Of 27 Congo red-positive study cases, 25 were then examined by immunohistochemical stains with antibodies to cytokeratin 5 (CK5) and cytokeratin 14 (CK14). Of 149 cases reviewed, 26 localized and 1 systemic vulvar amyloidosis were identified. Liquid chromatography-tandem mass spectrometry analysis of the deposits revealed unique peptide profile consistent with CK5 and CK14. Immunohistochemical staining with antibodies to CK5 and CK14 also detected these components in the deposits. The vulvar deposit of systemic amyloidosis consisted of amyloid light chain (?)-type amyloid deposit. All control cases were negative for Congo red. Keratin-associated amyloid materials (CK5 and CK14) were found to be unique in localized vulvar amyloidosis. Leakage of keratins from the basal layer of the epithelium into the superficial dermis may have been the possible source of the deposits. It appears to be associated with both high-grade and low-grade vulvar intraepithelial neoplasias and, rarely, lichen sclerosus, seborrheic keratosis, and benign vulvar skin. PMID:25149547

Quddus, M Ruhul; Sung, C James; Simon, Rochelle A; Lawrence, W Dwayne

2014-10-01

65

"Light cupula" involving all three semicircular canals: A frequently misdiagnosed disorder.  

PubMed

Though benign paroxysmal positional vertigo (BPPV) is the most common vestibular disorder causing positional vertigo, patients with typical positional vertigo in which the findings of positional nystagmus do not meet the diagnostic criteria for BPPV are often encountered in the clinic. Recently a concept of the light cupula was introduced, which accounts for some of positional vertigo. Under a normal condition in which the specific gravity of the cupula is same as that of the surrounding endolymph, semicircular canals (SCCs) are not influenced by the gravity. The light cupula, which indicates cupula with lower specific gravity than the surrounding endolymph, is characterized by persistent geotropic direction-changing positional nystagmus (DCPN) without latency on the supine head-roll test and the presence of a null plane. Unless the duration and pattern of positional nystagmus are carefully examined, the light cupula can be misdiagnosed as other types of BPPV. We present a patient with light cupula on the right side who reported recurrent episodes of positional vertigo and had been diagnosed as BPPV with multiple canal involvement (posterior and lateral SCCs) on the opposite side. In this study, we present the mechanism of typical positional nystagmus patterns in patients with light cupula involving all of the unilateral SCCs, and discuss the possible causes of misdiagnosis of the light cupula. PMID:25249441

Kim, Chang-Hee; Shin, Jung Eun; Shin, Dong Hyuk; Kim, Yong Won; Ban, Jae Ho

2014-11-01

66

Lymphomatoid papulosis misdiagnosed as pityriasis lichenoides et varioliformis acuta: Two case reports and a literature review  

PubMed Central

The aim of this study was to improve the level of diagnosis and differential diagnosis of lymphomatoid papulosis (LyP). Two cases of type B LyP were identified and the literature was reviewed to summarize the clinical outcomes and pathology of LyP and its treatment. The two patients exhibited symptoms with papulonodular lesions, the centers of which gradually underwent ulceration and necrosis. CD30, a helper T-cell marker specifically expressed in tumor cells was analyzed by immunohistochemical staining and the result showed that CD30-negative or only scattered CD30-positive cells were present. Therefore, a diagnosis of type B LyP was made. A fairly good curative effect was achieved following treatment with retinoic acid, glucocorticoids and immunomodulatory drugs. LyP is a type of low-level malignant lymphoma and is easily misdiagnosed as pityriasis lichenoides et varioliformis acuta and other diseases. In order to avoid under diagnosis and misdiagnosis, doctors should evaluate suspected patients by histopathological and immunohistochemical examination. PMID:25371758

ZHENG, YAN; JIA, JINJING; TIAN, QIONG; DONG, XINYU; WANG, XIN; YING, ZHAOXIA; XIAO, SHENGXIANG; LI, WENSHENG

2014-01-01

67

Fetal t(5p;21q) misdiagnosed as monosomy 21: A plea for in situ hybridization studies  

SciTech Connect

We report a case of 45,XY,-5,-21,+der (5)t(5;21) (p13 or p14;q11.2 or q21) that was prenatally misdiagnosed as complete monosomy 21 and terminated at 24 weeks of gestation. Subsequent fluorescence in situ hybridization studies with a chromosome 21 painting probe documented the cryptic unbalanced translocation. 17 refs., 2 figs., 1 tab.

Gill, P.; Uhrich, S.; Cheng, E.; Disteche, C. [Univ. of Washington Medical Center, Seattle, WA (United States)

1994-10-01

68

Immediate reconstruction of the maxillary sinus after resection of preoperatively misdiagnosed unicystic ameloblastoma with an ectopic third molar.  

PubMed

We report a case of unicystic ameloblastoma associated with an ectopic third molar in the right maxillary sinus, which was misdiagnosed as a dentigerous cyst on preoperative small incisional biopsy. Surgical enucleation of the cystic lesion was performed under general anesthesia with immediate reconstruction of the maxillary sinus using titanium mesh plate. The patient's postoperative recovery was uneventful, and there was no evidence of tumor recurrence during the 7-month follow-up period. PMID:25569416

Kang, Shin Hyuk; Bae, Tae Hui; Kim, Han Koo; Kim, Woo Seob; Kim, Mi Kyung

2015-01-01

69

Family history unawareness of blood clot risk: links to misdiagnoses and illness uncertainties in personal and expert realms.  

PubMed

The difficulty of diagnosing blood clots makes salient the question, "What role does family history awareness have for guiding lay and expert actions?" The authors examine the in-depth life reflection interviews of 20 women who experienced a first venous blood clot between the ages of 18 and 50 years, identifying causal attributions the women made for thrombosis after the event. Twelve participants described an understanding of the cascade of events linked to thrombosis, revealing that there is seldom a single cause. The other eight identified belief in a single determining cause for their thrombosis. The authors reflect on the symptoms the women experienced during the course of the clotting event, patterns of care that they executed to self-manage their blood clot, and their misdiagnoses associated with symptoms and care. The women recalled the patterns of care received through formal health care systems and the reported misdiagnoses linked to these interactions. The recollections reveal that the subtle nature of venous blood clot symptoms contributes to lay and expert misdiagnoses. Use of antibiotics and pain killers in the wake of misdiagnosis masks symptoms, contributing to costly delays in accurate diagnoses. Four women were aware of a family history of clotting when the event occurred, 13 had such a history but lacked awareness until the clotting event, and three had no known history. Among women with awareness of their family history, blood clot diagnosis occurred sooner, promoting survival and efficiencies in health care. Implications for communicating about family history of thrombosis are considered. PMID:24794077

Parrott, Roxanne; Hong, Soo Jung; Greenberg, Marisa

2015-01-01

70

Characteristics of patients misdiagnosed with Alzheimer’s disease and their medication use: an analysis of the NACC-UDS database  

PubMed Central

Background This study compared individuals whose clinical diagnosis of Alzheimer’s disease (AD) matched or did not match neuropathologic results at autopsy on clinical and functional outcomes (cognitive impairment, functional status and neuropsychiatric symptoms). The study also assessed the extent of potentially inappropriate medication use (using potentially unnecessary medications or potentially inappropriate prescribing) among misdiagnosed patients. Methods Longitudinal data from the National Alzheimer’s Coordinating Center Uniform Data Set (NACC-UDS, 2005–2010) and corresponding NACC neuropathological data were utilized to compare 88 misdiagnosed and 438 accurately diagnosed patients. Results Following adjustment of sociodemographic characteristics, the misdiagnosed were found to have less severe cognitive and functional impairment. However, after statistical adjustment for sociodemographics, dementia severity level, time since onset of cognitive decline and probable AD diagnosis at baseline, the groups significantly differed on only one outcome: the misdiagnosed were less likely to be depressed/dysphoric. Among the misdiagnosed, 18.18% were treated with potentially inappropriate medication. An additional analysis noted this rate could be as high as 67.10%. Conclusions Findings highlight the importance of making an accurate AD diagnosis to help reduce unnecessary treatment and increase appropriate therapy. Additional research is needed to demonstrate the link between potentially inappropriate treatment and adverse health outcomes in misdiagnosed AD patients. PMID:24354549

2013-01-01

71

Efficacy of inosine pranobex oral therapy in subclinical human papillomavirus infection of the vulva: a randomized double-blinded placebo controlled study.  

PubMed

A randomized double-blind placebo controlled study was carried out to assess the efficacy of inosine pranobex (1 g orally 3 times a day for 6 weeks) in the treatment of symptomatic subclinical human papillomavirus infection of the vulva. In a series of 55 women, 22 patients in the inosine pranobex group and 24 patients in the placebo group were suitable for analysis. A total of 14 (63.5%) of the inosine pranobex treated patients and 4 (16.7%) of the placebo treated patients showed significant vulval epithelial morphological improvement (P = 0.005) at 2 months after initiation of treatment. Whereas 13 (59.1%) and 9 (37.5%) patients in the respective groups showed significant improvement in the severity of pruritus vulvae (P = 0.435). Twelve (66.7%) of 18 patients with morphological improvement compared to 10 (35.7%) of 28 patients with no morphological improvement experienced significant symptomatic alleviation of pruritus vulvae (P = 0.041). Similar results were seen at the second assessment 4 months after the initiation of treatment. Adverse drug reactions were reported by 2 patients in the treatment group and by 2 patients (skin rash) in the placebo group. These adverse reactions were mild and self limiting. It is concluded that inosine pranobex demonstrated a significant pharmacological activity in subclinical HPV infection of the vulva and should be considered an alternative treatment for the condition. PMID:8876359

Tay, S K

1996-07-01

72

Nonlesions, misdiagnoses, missed diagnoses, and other interpretive challenges in fish histopathology studies: a guide for investigators, authors, reviewers, and readers  

USGS Publications Warehouse

Differentiating salient histopathologic changes from normal anatomic features or tissue artifacts can be decidedly challenging, especially for the novice fish pathologist. As a consequence, findings of questionable accuracy may be reported inadvertently, and the potential negative impacts of publishing inaccurate histopathologic interpretations are not always fully appreciated. The objectives of this article are to illustrate a number of specific morphologic findings in commonly examined fish tissues (e.g., gills, liver, kidney, and gonads) that are frequently either misdiagnosed or underdiagnosed, and to address related issues involving the interpretation of histopathologic data. To enhance the utility of this article as a guide, photomicrographs of normal and abnormal specimens are presented. General recommendations for generating and publishing results from histopathology studies are additionally provided. It is hoped that the furnished information will be a useful resource for manuscript generation, by helping authors, reviewers, and readers to critically assess fish histopathologic data.

Wolf, Jeffrey C.; Baumgartner, Wes A.; Blazer, Vicki S.; Camus, Alvin C.; Engelhardt, Jeffrey A.; Fournie, John W.; Frasca, Salvatore, Jr.; Groman, David B.; Kent, Michael L.; Khoo, Lester H.; Law, Jerry M.; Lombardini, Eric D.; Ruehl-Fehlert, Christine; Segner, Helmut E.; Smith, Stephen A.; Spitsbergen, Jan M.; Weber, Klaus; Wolfe, Marilyn J.

2015-01-01

73

Nonlesions, misdiagnoses, missed diagnoses, and other interpretive challenges in fish histopathology studies: a guide for investigators, authors, reviewers, and readers.  

PubMed

Differentiating salient histopathologic changes from normal anatomic features or tissue artifacts can be decidedly challenging, especially for the novice fish pathologist. As a consequence, findings of questionable accuracy may be reported inadvertently, and the potential negative impacts of publishing inaccurate histopathologic interpretations are not always fully appreciated. The objectives of this article are to illustrate a number of specific morphologic findings in commonly examined fish tissues (e.g., gills, liver, kidney, and gonads) that are frequently either misdiagnosed or underdiagnosed, and to address related issues involving the interpretation of histopathologic data. To enhance the utility of this article as a guide, photomicrographs of normal and abnormal specimens are presented. General recommendations for generating and publishing results from histopathology studies are additionally provided. It is hoped that the furnished information will be a useful resource for manuscript generation, by helping authors, reviewers, and readers to critically assess fish histopathologic data. PMID:25112278

Wolf, Jeffrey C; Baumgartner, Wes A; Blazer, Vicki S; Camus, Alvin C; Engelhardt, Jeffery A; Fournie, John W; Frasca, Salvatore; Groman, David B; Kent, Michael L; Khoo, Lester H; Law, Jerry M; Lombardini, Eric D; Ruehl-Fehlert, Christine; Segner, Helmut E; Smith, Stephen A; Spitsbergen, Jan M; Weber, Klaus; Wolfe, Marilyn J

2015-04-01

74

Defining the concept of locally advanced squamous cell carcinoma of the vulva: a new perspective based on standardization of criteria and current evidence  

PubMed Central

The phrase "locally advanced carcinoma of the vulva" has often been mentioned in the literature, though not accurately defined, or even leading to the interpretation overlapping. Grounded on cervical cancer experience, we are able to state that designing a tailored primary strategy based on clinically measurable adverse prognostic factors represents the cornerstone of therapy. This fact urged us to rethink about the real usefulness of the concept of locally advanced squamous cell carcinoma of the vulva. We will refer to this concept as a clinical entity emerging from a rigorous workup which is a valuable guiding tool in the context of a thorough debate about the best primary treatment approach to be used. Furthermore, bulky tumors of the vulva have been associated with a worse prognosis on several occasions. Some authors have questioned the fact that tumor size has not been considered in the staging system. Finally, a standardized definition will help us compare the results obtained, which is extremely necessary given the worldwide low prevalence of this disease. PMID:25142626

Soderini, Alejandro H.; Cuneo, Nicasio A.

2014-01-01

75

Posterior microphthalmos and papillomacular fold-associated cystic changes misdiagnosed as cystoid macular edema following cataract extraction  

PubMed Central

Purpose Novel spectral-domain optical coherence tomography (SD-OCT) findings in posterior microphthalmos (PM) include cystoid changes in the papillomacular fold (PMF). These changes may be misdiagnosed as cystoid macular edema (CME) and may trigger unnecessary treatment including intravitreal injections. We report a case that underscores this scenario aiming to increase awareness of this entity among ophthalmologists. Method A case report. Results A 25-year-old male presented with a history of clear lens extraction in both eyes as a refractive procedure. Postoperatively, he was diagnosed with CME and received five intravitreal bevacizumab injections in each eye as well as oral diamox for persistent cystic spaces noted on OCT. He was referred to our institution with the diagnosis of non-responding CME. A complete ophthalmic evaluation, including ultrasonography and SD-OCT, confirmed the diagnosis of PM and PMF with cystic cavities in the PMF. A fluorescein angiogram disclosed absence of macular leakage or optic nerve head staining indicating that the cystic cavities seen on SD-OCT are not due to postoperative CME but are rather the intrinsic cystic changes commonly seen in eyes with PM and a PMF. These cystic cavities were incorrectly thought to represent postoperative CME, which triggered the unnecessary treatment and lack of response. Conclusion Cystic-like cavities are a component of the PMF in PM eyes and may be misdiagnosed as CME, especially in a postoperative setting. This case underscores the importance of understanding the intrinsic features of the PMF in eyes with PM and may help increase awareness among ophthalmologists of such a potentially confusing scenario. PMID:25609908

Albar, Ahmad A; Nowilaty, Sawsan R; Ghazi, Nicola G

2015-01-01

76

A Rare Case of Extrafollicular Adenomatoid Odontogenic Tumour in the Posterior Region of the Mandible: Misdiagnosed as Residual Cyst  

PubMed Central

Adenomatoid odontogenic tumor is a relatively uncommon distinct odontogenic neoplasm. It is an uncommon tumor of odontogenic origin with varying number of ductlike structures and inductive changes in the stroma. It is a benign and slow growing epithelial tumor and represents 3% of all odontogenic tumors. Its occurrence is more common in anterior region of the maxilla than mandible. Most of the adenomatoid odontogenic tumors occur intra-osseously but few peripheral variant have been reported which are attached to the gingival structures. The intra-osseous Adenomatoid odontogenic tumor may be related to unerrupted tooth (follicular varient) or may not (extrafollicular varient) be related to unerrupted tooth. This paper is to present a rare case of an extrafollicular Adenomatoid odontogenic tumor occurring in the body of the mandible in a male patient which is distinct and secondly it was clinically and radiographically diagnosed as residual cyst. The diagnosis of Adenomatoid odontogenic tumor was confirmed by Histopathological investigation. How to cite this article: Shivali V, Khanna VD, Khanna P, Singh A, Pandey A, Ahuja T. A Rare Case of Extrafollicular Adenomatoid Odontogenic Tumour in the Posterior Region of the Mandible: Misdiagnosed as Residual Cyst. J Int Oral Health 2013; 5(5):124-8. PMID:24324316

Shivali, Vaid; Pandey, Anil; Khanna, Vidhi D; Khanna, Prateek; Singh, Ashish; Ahuja, Tarun

2013-01-01

77

Aggressive angiomyxoma of the vulva: intra-operative pathological diagnosis is useful in deciding the scope of surgery and reducing recurrence.  

PubMed

Aggressive angiomyxoma (AA) is a rare, slow-growing myxoid neoplasm of the pelvi-perineum. Because of its rarity, it is often initially misdiagnosed, frequently as a gynaecological malignancy. Surgical resection is the main treatment modality of AA, but, local recurrence rates are high. In order to reduce recurrence, the scope of surgical resection should be as broad as possible. Intra-operative pathological diagnosis is useful in deciding the scope of surgery, and wide excision may reduce recurrence. PMID:22442917

Wang, Q; Zhao, M; Lin, X; Zhong, W; Gao, Y

2012-01-01

78

Misdiagnosed Hypomanic Symptoms in Patients with Treatment-Resistant Major Depressive Disorder in Italy: Results from the Improve Study  

PubMed Central

Background:Undiagnosed and therefore inadequately treated hypomanic symptoms may be a leading cause of drug resistance in depression diagnosed as unipolar (major depressive disorder, MDD). The purpose of the IMPROVE study was to identify the rate of misdiagnoses in patients with treatment-resistant MDD by screening for the presence of previous hypomanic episodes, and to study the characteristics of those patients with a positive history of hypomania. Methods:Patients attending 29 psychiatric units throughout Italy with a diagnosis of MDD who were resistant to anti-depressant treatment were included in this multicentre, observational single visit study. The Hypomania Checklist 32 (HCL-32) was administered to detect underlying bipolarity. Results: Among the 466 enrolled patients, 256 (57.40%) were positive at screening for a previous hypomanic episode (HCL-32 ?12), therefore suggesting a misdiagnosis. These patients scored higher than those with a negative history in both the “active/elated hypomania” (11.27±3.11 vs 3.57±3.05; P<0.0001) and “irritable/risk-taking hypomania” (2.87±2.03 vs 2.06±1.73; P<0.001) HCL-32 sub-scales. Patients with a positive history of hypomania were younger, had a higher number of previous depressive episodes and a higher frequency of comorbid conditions compared to those with a negative history. Conclusions:This study suggests that screening for hypomania in MDD-resistant patients facilitates identification of a notable proportion of undiagnosed cases of bipolar spectrum disorder. Patients with a positive history of hypomania at screening had a demographic/clinical bipolar-like profile that included young age, higher number of previous depressive episodes and higher frequency of comorbid conditions. They also had both higher active and irritable hypomania symptom scores. PMID:24761153

Francesca, Moro Maria; Efisia, Lecca Maria; Alessandra, Ghillani M.; Marianna, Alacqua; Giovanni, Carta Mauro

2014-01-01

79

Aggressive angiomyxoma of vulva.  

PubMed

A lady of 44 years presented with progressively growing non-tender mass in the right labia majora over a period of one year. Ultrasound showed large perineal mass with predominantly echogenic low resistance type of arterial blood flow at different places on ultrasound. CT scan showed well-defined margins with attenuation less than that of muscle. MRI showed high signal intensity related to loose myxoid matrix and high water content of angiomyxoma. PMID:23823959

Bakhtiar, Umber Jalil; Awan, Azra Saeed

2013-07-01

80

Angiomyofibroblastoma of the vulva.  

PubMed

Angiomyofibroblastoma is a benign well-circumscribed tumor characterized by alternating hypocellular and hypercellular areas with abundant thin-walled blood vessels. The tumor cells are bland and spindle-shaped or epitheloid and tend to concentrate around the vessels or cluster in small nests. Herein, we report a case of angiomyofibroblastoma of the left labia major in a 50-year-old female. The tumor measured 18 x 16 x 11 cm and appeared as an ulcerated rubbery vulvar mass with rapid enlargement during one month. Ultrasonography demonstrated a soft tissue tumor with homogeneous echo and normal vascularity. Histologically, cells were positive for vimentine, desmin, and estrogen and progesterone receptors but negative for cytokeratin; all in favor of the diagnosis of angiomyofibroblastoma. PMID:18298306

Barat, Shahnaz; Tirgar-Tabari, Soudabeh; Shafaee, Shahryar

2008-03-01

81

Angiomyofibroblastoma of the vulva.  

PubMed

A 30-year-old female presented with unilateral labial enlargement. The clinical impression was that of a benign cyst. The microscopic features were that of angiomyofibroblastoma showing hyper and hypocellular areas containing spindle and plump stromal cells admixed with blood vessels. This tumour is benign with extremely low rate of recurrence. Surgery is the only treatment as in this case. PMID:22313649

Ibnerasa, Shazia N; Yasmeen, Fauzia; Shami, Nabila

2012-02-01

82

Lymphoepithelioma-like carcinoma of the vulva, an underrecognized entity? Case report with a single inguinal micrometastasis detected by sentinel node technique  

PubMed Central

This report describes an unusual EBV-negative lymphoepithelioma-like carcinoma of the vulva in a 73-year-old patient. The lesion was localised at the right minor labium and was resected by partial vulvectomy. A synchronous sentinel lymph node biopsy revealed a single micrometastasis in the right inguinal region, which prompted local radiotherapy. Follow-up nine months later showed only slight vulvar atrophy, without signs of local recurrence or distant metastases. Although lymphoepithelioma-like carcinomas of the skin and the female genital tract are presumed to have a better prognosis than their counterparts in the upper aerodigestive tract, possibly due to earlier detection and therapy, this case documents their potential for early metastasis. PMID:21219641

2011-01-01

83

CO2 laser ablation of external genital lesions with a SwiftLase flashscanner: treatment of extramammary Paget's disease of the vulva, penile condylomata, and other lesions  

NASA Astrophysics Data System (ADS)

The ability to vaporize extremely thin layers of epithelial tissue without any char and with minimal thermal necrosis is extremely advantageous in the treatment of superficial lesions of the external genitalia. We present a novel CO2 laser `SwiftLase' flashscan technology capable of providing char free ablation of 3 mm diameter lesions with only 150 micron residual thermal necrosis depth at power level as low as 10 watts. These power levels are achievable with a small transportable CO2 laser. The SwiftLaser is a miniature opto- mechanical scanner which homogeneously covers a 3 mm diameter surface with a 0.1 mm spot size focused beam within 0.1 seconds. The instantaneous beam's dwelling time is 1 millisecond. The instantaneous power density level at the focal point is higher than the threshold for char free ablation, thus providing a large char free ablation crater. Since depth of each ablated layer is 0.1 mm, the depth of treatment can be precisely controlled. The SwiftLaser technology has extensively and successfully been used in the last two years for the treatment of HPV in female lower tracts (Vulvectomy). The same technique may be performed with extramammary Paget's disease of the vulva, penile condylomata, and other epithelial disorders of the external genitalia without damage to surrounding healthy tissue. Technique and clinical results will be discussed.

Sacknoff, Eric J.; Schweitzer, Jay; Slatkine, Michael; Mead, Douglass S.

1995-05-01

84

Primary undifferentiated embryonal sarcoma of the liver misdiagnosed as hydatid cyst in a child: a case report and review of the literature.  

PubMed

Primary undifferentiated embryonal sarcoma (UES) of the liver is a highly malignant mesenchymal origin tumor and has a peak incidence between the ages of 6 and 10 years. We hereby report a case of primary UES of the liver in a 7-year-old male patient who initially was misdiagnosed and treated as hydatid cyst of the liver. The tumor was occupying almost the entire right lobe of the liver and had a mostly cystic appearance with some solid components in it. Because hydatid disease is endemic in this region, it can often lead to misdiagnosis. The correct diagnosis was established after a biopsy and following neo-adjuvant chemotherapy the patient underwent a successful right hepatic lobectomy with complete resection of the tumor. The patient also received adjuvant chemotherapy and is currently disease-free in the present six month period. Primary UES of the liver has a predominantly solid appearance on US in contrast to its mostly cystic appearance on CT and MRI. These paradoxical imaging findings should be kept in mind in order to be able to distinguish this rare tumor from other entities, especially hydatid cyst. Thus, early diagnosis and prompt surgical resection of these tumors together with adjuvant and/or neo-adjuvant chemotherapy can provide complete remission. PMID:25603636

Halefoglu, A M; Oz, A

2014-01-01

85

Giant cell angiofibroma misdiagnosed as a vascular malformation and treated with absolute alcohol for one year: a case report and review of the literature  

PubMed Central

Purpose To present the clinical, imaging, pathological and immunohistochemical features of giant cell angiofibroma (GCA). Case presentation In this paper we report an atypical case of a GCA extending from the parotid to the parapharyngeal space. The lesion was being treated as a vascular malformation for one year prior to surgical removal. We summarize the clinical manifestations, imaging, pathological and molecular features of this rare disease. After complete surgical removal of the tumor, immunohistochemical analysis revealed strong positivity for the mesenchymal markers vimentin, CD34, CD31 and CD99 in neoplastic cells. Tumor proliferation antigen marker Ki67 was partly positive (<5% of cells). Tumor cells were negative for muscle-specific actin, epithelial membrane antigen, smooth muscle actin, cytokeratin pan, S100, desmin, glial fibrillary acidic protein, myogenin, MyoD1 and F8. The morphological and immunohistochemical profile was consistent with the diagnosis of GCA. Conclusion GCA is a rare soft tissue tumor that can easily be misdiagnosed in the clinical preoperative setting. In view of the clinical, pathological and molecular features of the tumor, complete surgical removal is the current optimal treatment option, providing accurate diagnosis and low to minimal recurrence rate. PMID:24758544

2014-01-01

86

An AGEF-1/Arf GTPase/AP-1 Ensemble Antagonizes LET-23 EGFR Basolateral Localization and Signaling during C. elegans Vulva Induction  

PubMed Central

LET-23 Epidermal Growth Factor Receptor (EGFR) signaling specifies the vulval cell fates during C. elegans larval development. LET-23 EGFR localization on the basolateral membrane of the vulval precursor cells (VPCs) is required to engage the LIN-3 EGF-like inductive signal. The LIN-2 Cask/LIN-7 Veli/LIN-10 Mint (LIN-2/7/10) complex binds LET-23 EGFR, is required for its basolateral membrane localization, and therefore, vulva induction. Besides the LIN-2/7/10 complex, the trafficking pathways that regulate LET-23 EGFR localization have not been defined. Here we identify vh4, a hypomorphic allele of agef-1, as a strong suppressor of the lin-2 mutant Vulvaless (Vul) phenotype. AGEF-1 is homologous to the mammalian BIG1 and BIG2 Arf GTPase guanine nucleotide exchange factors (GEFs), which regulate secretory traffic between the Trans-Golgi network, endosomes and the plasma membrane via activation of Arf GTPases and recruitment of the AP-1 clathrin adaptor complex. Consistent with a role in trafficking we show that AGEF-1 is required for protein secretion and that AGEF-1 and the AP-1 complex regulate endosome size in coelomocytes. The AP-1 complex has previously been implicated in negative regulation of LET-23 EGFR, however the mechanism was not known. Our genetic data indicate that AGEF-1 is a strong negative regulator of LET-23 EGFR signaling that functions in the VPCs at the level of the receptor. In line with AGEF-1 being an Arf GEF, we identify the ARF-1.2 and ARF-3 GTPases as also negatively regulating signaling. We find that the agef-1(vh4) mutation results in increased LET-23 EGFR on the basolateral membrane in both wild-type and lin-2 mutant animals. Furthermore, unc-101(RNAi), a component of the AP-1 complex, increased LET-23 EGFR on the basolateral membrane in lin-2 and agef-1(vh4); lin-2 mutant animals. Thus, an AGEF-1/Arf GTPase/AP-1 ensemble functions opposite the LIN-2/7/10 complex to antagonize LET-23 EGFR basolateral membrane localization and signaling. PMID:25329472

Skorobogata, Olga; Escobar-Restrepo, Juan M.; Rocheleau, Christian E.

2014-01-01

87

Aggressive angiomyxoma of the vulva.  

PubMed

Aggressive angiomyxoma is a rare, benign neoplasm occurring in 3(rd) to 5(th) decade of life that can be mistaken both clinically and on microscopy for several other conditions, it should be included as a differential diagnosis for any vaginal mass. These lesions have a predilection for female pelvic soft tissues, slow in growth, and are characterized histologically by a predominantly myxoid stroma and an abundance of thin and thick walled vascular channels. This is a deep soft tissue tumor, which as the name suggests, may have a locally aggressive course. Most tumors occur in women and are large, usually greater than 10 cm, slowly growing, and painless. Standard of care treatment for angiomyxoma has been surgery. Some authors believe that it is the only possible treatment, but surgery is often radical and can be mutilating, with massive blood loss. PMID:22923982

Barmon, Debabrata; Kataki, Amal Chandra; Sharma, J D; Bordoloi, Judy

2012-01-01

88

Sparganosis in Russell's viper snake: a case report.  

PubMed

The occurrence of the plerocercoid larva, Sparganum of Sparganum spp. in two Russell's viper snakes maintained in Chennai snake park trust, Chennai is reported for the first time from Southern India. The cestode larvae were found in the sub cutis and were flat, solid, wrinkled, ribbon like creamy white in colour with peudosegmentation with anterior end possessing bothria. The cuticles, subcuticular cells and parenchymatous tissue stained by acetic alum carmine further confirmed the cestode larvae. PMID:25320490

Kavitha, K T; Latha, B R; Bino Sundar, S T; Sridhar, R; Abdul Basith, S

2014-12-01

89

[Ocular sparganosis in the Czech Republic--a case report].  

PubMed

The authors report a case of 14-year-old boy presented to the Ophthalmologic Department of University Hospital in Olomouc with the diagnosis af acute anterior uveitis. A living parasite has been detected in the anterior chamber in a slit lamp examination. The vitreous and retina remained uninvolved. The acute iridocyclitis associated with parasitic infection is a very rare cause of anterior uveitis in Central Europe. The patient underwent surgical removal of the parasite via paracentesis. The inflammation resolved under the treatment with atropine and dexamethasone drops within a few days. Histopathological examination revealed the parasite as a young larval stage of tapeworm from family Pseudophyllidea (sparganum). Based on the analysis of development cycles of different types of tapeworms and according the literature data on tapeworms found in the Czech Republic genus Spirometra seemed to be the most plausible cause of the patient's disease. As the most probable source of viable parasites authors suspect swallowed water containing tiny infected crustaceans in the dam near the town Olomouc in Moravia. PMID:16958022

Rehák, M; Kolárová, L; Kohnová, I; Rehák, J; Mohlerová, S; Fric, E; Chrapek, O

2006-08-01

90

Methamphetamine Ingestion Misdiagnosed as Centruroides sculpturatus Envenomation  

PubMed Central

The authors present a case report of a 17-month-old female child who ingested a large amount of methamphetamine that looked very similar clinically to a scorpion envenomation specific to the southwestern United States by the species Centruroides sculpturatus. The child was initially treated with 3 vials of antivenom specific for that scorpion species and showed a transient, though clinically relevant neurologic improvement. Her clinical course of sympathomimetic toxicity resumed and she was treated with intravenous fluids and benzodiazepines after blood analysis showed significant levels of d-methamphetamine. This case report is to specifically underline the clinical confusion in discerning between these two conditions and the realization of limited and/or expensive resources that may be used in the process. PMID:25649670

Strommen, Joshua; Shirazi, Farshad

2015-01-01

91

Vascular Anomalies in Children Misdiagnosed with Asthma  

PubMed Central

In most asthmatic children, inhaled steroids can relieve and control the symptoms of asthma. Persistent wheezing and respiratory symptoms in young children despite appropriate treatment may indicate other diagnostic considerations. Delays in this diagnosis can result in unnecessary investigations, inappropriate treatment and further complications. We report three patients who presented to Sultan Qaboos University Hospital, Muscat, Oman, in the period between September 2010 and May 2012 with persistent wheezing due to compression of the trachea caused by vascular anomalies. All patients had double aortic arches putting pressure on the trachea, leading to respiratory manifestations and feeding problems. Following surgery, all cases showed improvement and no longer required medication. Without clinical suspicion and appropriate imaging, congenital vascular anomalies may remain undetected for years. Infants and children with chronic wheezing should be evaluated for vascular anomalies as soon as possible. General practitioners should refer all such patients to a tertiary-level hospital for further investigations and management. PMID:25685375

Javad, Hashim; Al-Sineidi, Khalfan; Abdelmogheth, Anas A.; Sankhla, Dilip; Al-Dhuhli, Humoud; Azzawi, Sinan I.; El-Naggari, Mohamed A.

2015-01-01

92

Psychiatric misdiagnoses in Dandy-Walker variant.  

PubMed

Cases of intellectual impairment and aberrant behavior in patients with cerebellar diseases have been described since the early nineteenth century. Here, we report on a patient suffering from Dandy-Walker variant who presented with symptoms of obsessive compulsive disorder and delusional disorder. The current findings emphasize the potential relevance of focal cerebellar lesions as organic correlates of these disorders. PMID:25058305

Blaettner, C; Pfaffenberger, N M; Cartes-Zumelzu, F; Hofer, A

2015-08-01

93

Cerebral Vein Thrombosis Misdiagnosed and Mismanaged  

PubMed Central

Cerebral venous thrombosis (CVT) should be considered in the differential diagnosis of all unexplained CNS disorders of sudden onset. Etiological factors are often subclinical forms of several common thrombophilic states occurring together, rather than the typical inherited and rare causes. Diagnosis is missed because of the heterogeneity in clinical presentation and etiological factors. In several patients with the so called idiopathic CVT nutritional deficiencies and lifestyle issues are more important factors in pathogenesis, rather than single rarer causes. High index of suspicion is the key to diagnosis. Clinical skill has to be fine tuned to diagnose the problem and to identify all the etiological factors. Radiology is essential for diagnosis but relying on radiology alone will lead to missing several cases and even erroneous diagnosis. It is inappropriate to proceed prematurely to laboratory investigations, forgetting proper clinical evaluation by studying diet, lifestyle, and environment of the patients. Success in managing lies in identifying all the contributory causes and correcting all of them giving excellent outcome almost always. Clinical observations based on case series and sharing of such information alone are the means to arrive at a consensus in diagnosis and management. PMID:22567255

Sasidharan, P. K.

2012-01-01

94

Aggressive angiomyxoma of the vulva and vagina  

Microsoft Academic Search

Aggressive angiomyxoma (AA) is a rare myofibroblastic tumor, usually affecting young women. Two patients, one with a vaginal and the other with a vulvar mass underwent surgical intervention with different preoperative diagnoses; the former as vaginal cyst and the latter as vulvar hernia. Unfortunately, the pathological evaluation of the specimens revealed aggressive angiomyxoma. Misdiagnosis of this tumor is a common

Tayfun Güngör; Sema Zengero?lu; Asl? Kaleli; Gamze Mocan Kuzey

2004-01-01

95

[Angiomiofibroblastoma of the vulva. Report of case].  

PubMed

Angiomyofibroblastoma is a benign mesenchymal tumor of the lower genital tract described in 1992 by Fletcher and his group. Must be differentiated mainly from aggressive angiomyxoma, which has a high local recurrence rate. We report the case of a 21 year old patient who attended the General Hospital Dr. Miguel Silva, in Morelia, Michoacan, because post-term pregnancy of 41.1 weeks gestation, with a bulky vulvar tumor, asymptomatic with four years of evolution. Cesarean section and vulvar tumor resection were performed. The surgical specimen measured 14 x 10 x 5 cm, had a polypoid aspect, multilobulated, with nodules of varying size. From a microscopic point of view the tumor was well defined, formed by loose connective tissue septa, with stromal fusiform cells and benign characteristics, between collagen fibers, with abundant vessels. The histochemical studies were positive for desmin and vimentin. These anatomopathological findings are diagnostic of vulvar angiomyofibroblastoma, benign course tumor, does not resort nor does it generate metastases after simple surgical resection; however, recurrence in the vagina is reported. Must be differentiated from other mesenchymal neoplasms of the genital tract. PMID:23837300

Pérez-Martínez, Andrés; Chávez-Martínez, Sareni; Sereno-Coló, José Antonio; Arias-González, María Leilanie

2013-06-01

96

Angiomyofibroblastoma of the vulva during pregnancy.  

PubMed

Angiomyofibroblastoma is a rare, benign and recently defined soft tissue tumor. It generally arises from superficial soft tissues, especially from mesenchymal cells in the subepithelial myxoid stromal zone of the vulvovaginal region. The tumor is usually positive for estrogen and progesterone receptor. We report a pregnant woman who developed vulvar angiomyofibroblastoma within 2 months. The tumor was negative for estrogen and progesterone receptor. PMID:21501329

Cetinkaya, Kadir; Al, Rag?p Atakan; Gursan, Nesrin

2011-08-01

97

Huge pedunculated angiomyofibroblastoma of the vulva.  

PubMed

We present the case of a huge pedunculated benign mesenchymal myxoid tumor that developed on the right labia majora of a 48-year-old-woman. The excised mass weighed 4534 g and was 23 cm in diameter; the cut surface was yellowish and elastic. Microscopic examination revealed spindle and plump oval tumor cells arranged with abundant capillary vessels in an edematous stroma. Immunohistochemical staining showed that the tumor cells were positive for vimentin, desmin, estrogen receptor, and progesterone receptor, but negative for alpha-smooth muscle actin, CD34, CD45, CD68, and S-100. Based on these features, the pathological diagnosis was angiomyofibroblastoma. A pedunculated angiomyofibroblastoma is extremely rare and, to the best of our knowledge, this is the biggest such tumor in terms of size and weight reported to date. It is especially important in such a huge mass greater than 10 cm that angiomyofibroblastoma is differentiated from aggressive angiomyxoma, which is a deeply invasive and recurrent neoplasm. PMID:20177728

Nagai, Kimihiro; Aadachi, Koji; Saito, Hitoaki

2010-04-01

98

Superior localisation and imaging of radiolabelled monoclonal antibody E48 F(ab')2 fragment in xenografts of human squamous cell carcinoma of the head and neck and of the vulva as compared to monoclonal antibody E48 IgG.  

PubMed Central

Monoclonal antibody (MAb) E48 and its F(ab')2 fragment, radiolabelled with 131I, were tested for tumour localisation and imaging in nude mice bearing a squamous cell carcinoma xenograft line derived from a head and neck carcinoma (HNX-HN) or from a vulva carcinoma (VX-A431). MAb IgG or F(ab')2 fragments were injected in parallel and at day 1, 2, 3 and 6 or 7, mice were either scanned with a gamma camera or dissected for determination of isotope biodistribution. In HNX-HN bearing mice, E48 IgG as well as F(ab')2 showed highly specific localisation in tumour tissue. The mean tumour uptake (n = 4) expressed as the percentage of the injected dose per gram of tumour tissue (percentage ID/g) of IgG was 11.9% at day 1 and increased to 14.6% at day 6 whereas percentage ID/g of F(ab')2 was 7.2% at day 1 and decreased during subsequent days. Tumour to blood ratios (T/B) at day 1 were 1.2 for IgG and 13.6 for F(ab')2 and reached a maximum at day 6 with values of 6.4 and 54.2 respectively. In VX-A431 bearing mice, only E48 F(ab')2 showed preferential localisation in tumour tissue. At day 1, Percentage ID/g of IgG was 3.7 and T/B was 0.3, while percentage ID/g of F(ab')2 was 2.4 and T/B was 3.2. Percentage ID/g decreased after day 1 while T/B increased. In these experiments no preferential localisation of either isotype matched 125I-labelled control IgG or F(ab')2 was observed. In F(ab')2 injected HNX-HN bearing mice as well as VX-A431 bearing mice, tumours could be visualised at day 1 and 2 without any appreciable background activity. With MAb IgG this was also possible in HNX-HN bearing mice (but not in VX-A431 bearing mice) but only at day 3 and 6. These findings suggest that the superior tumour to non-tumour ratios render the E48 F(ab')2 fragment more qualified for specific targeting of radioisotopes to tumour xenografts in this experimental setting. Images Figure 1 Figure 2 Figure 6 Figure 7 Figure 8 PMID:1989663

Gerretsen, M.; Quak, J. J.; Suh, J. S.; van Walsum, M.; Meijer, C. J.; Snow, G. B.; van Dongen, G. A.

1991-01-01

99

Pulmonary epithelioid hemangioendothelioma misdiagnosed as a benign nodule.  

PubMed

Pulmonary epithelioid hemangioendothelioma (PEH) is a rare vascular tumor of borderline malignancy that originates from endothelial cells. Chest computed tomography (CT) performed during a routine cancer screening revealed multiple small pulmonary nodules in a 50-year-old man who had previously undergone endoscopic submucosal dissection of early gastric cancer. To rule out metastatic nodules, a wedge resection of the left upper lobe was performed and the frozen biopsy reported a benign fibrotic nodule. Using immunohistochemistry, the final pathology was indicated to be PEH, and consecutive surgery for the right-side nodules was planned and performed. PMID:25778086

Kim, Minah; Chang, Jinsun; Choi, Hayoung; Oh, In-Jae; Park, Chul-Kyu; Kim, Young-Chul; Choi, Yoo-Duk; Yun, Ju-Sik; Song, Sang-Yun; Na, Kook-Joo

2015-12-01

100

Congenital chloride diarrhea misdiagnosed as pseudo-Bartter syndrome.  

PubMed

Congenital chloride diarrhea (CCD) is a rare autosomal recessive disease which is characterized by intractable diarrhea of infancy, failure to thrive, high fecal chloride, hypochloremia, hypokalemia, hyponatremia and metabolic alkalosis. In this case report, we present the first female and the second official case of CCD in Iran. A 15-month-old girl referred to our hospital due to failure to thrive and poor feeding. She had normal kidneys, liver and spleen. Treating her with Shohl's solution, thiazide and zinc sulfate did not result in weight gain. Consequently, pseudo-Bartter syndrome was suspected, she was treated with intravenous (IV) therapy to which she responded dramatically. In addition, hypokalemia resolved quickly. Since this does not usually happen in patients with the pseudo-Bartter syndrome, stool tests were performed. Abnormal level of chloride in stool suggested CCD and she was thus treated with IV fluid replacement, Total parentral nutrition and high dose of oral omeprazole (3 mg/kg/day). She gained 1 kg of weight and is doing fine until present. CCD is a rare hereditary cause of intractable diarrhea of infancy. It should be considered in infants with unknown severe electrolyte disturbances. PMID:24381629

Saneian, Hossein; Bahraminia, Emad

2013-09-01

101

Synovial haemangioma of the knee: a frequently misdiagnosed lesion  

Microsoft Academic Search

Objective. The objective of this study was to assess the contribution of magnetic resonance (MR) im- aging in the diagnosis and surgical planning of five cases of synovial haemangioma of the knee. Patients and methods. The clinical, radiological and ar- throscopic features of five pathologically proven syno- vial haemangiomas of the knee were retrospectively re- viewed. Results. A diagnostic delay,

A. Cotten; R.-M. Flipo; B. Herbaux; F. Gougeon; M. Lecomte-Houcke; P. Chastanet

1995-01-01

102

Intestinal angioedema misdiagnosed as recurrent episodes of gastroenteritis.  

PubMed

Emergency physicians (EP) frequently encounter angioedema involving the lips and tongue. However, angioedema from Angiotensin Converting Enzyme inhibitors or hereditary angioedema (HAE) can present with gastrointestinal symptoms due to bowel wall involvement. EPs should begin to consider this clinical entity as a potential cause for abdominal pain and associated gastrointestinal symptoms given the common use of medications that can precipitate angioedema. We report a case of a 34-year-old woman who presented with abdominal cramping, vomiting and diarrhea due to an acute exacerbation of HAE. PMID:21079716

Locascio, Edward J; Mahler, Simon A; Arnold, Thomas C

2010-09-01

103

Anti-NMDAR encephalitis misdiagnosed as Hashimoto's encephalopathy.  

PubMed

Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is a well-defined autoimmune disorder. Hashimoto's encephalopathy (HE) is a still controversial entity, lacking definite diagnostic criteria. We described a 14-year-old-girl presenting with a clinical picture consistent with the diagnosis of anti-NMDAR encephalitis, confirmed by NMDAR antibody testing. Four years earlier, she had presented a similar episode of acute encephalopathy diagnosed as HE. Anti-NMDAR encephalitis and HE share similar clinical features so that the differential diagnosis can be difficult if specific antibodies are not tested. The correct diagnosis of anti-NMDAR encephalitis is crucial to plan the appropriate management and follow-up, namely in term of oncological screening, since it can be paraneoplastic in origin. We suggest to re-evaluate the clinical history of all subjects with previous HE diagnosis in order to evaluate the possible diagnosis of anti-NMDAR encephalitis and plan the appropriate management of these patients. PMID:23953644

Mirabelli-Badenier, M; Biancheri, R; Morana, G; Fornarino, S; Siri, L; Celle, M E; Veneselli, E; Vincent, A; Gaggero, R; Mancardi, M M

2014-01-01

104

Nocturnal choking episodes: under-recognized and misdiagnosed.  

PubMed

Causes of nocturnal paroxysmal events include a variety of disorders such as epileptic seizures, parasomnias, sleep-related movement disorders, and psychiatric disturbances. Timing and semiology of the events, simultaneous video-electroencephalographic observation, presence of any daytime events, and relevant psychiatric and medical history may help in sorting out various possibilities considered in the differential diagnosis of such events. Timely diagnosis of these events is crucial for appropriate management; under-recognition and misdiagnosis of nonepileptic events is not uncommon. Described here are two cases within the spectrum of nocturnal paroxysmal events, one with nocturnal panic attacks and the other with frontal lobe epilepsy, each presenting with choking episodes. PMID:20933181

Elkay, Muruvet; Poduri, Annapurna; Prabhu, Sanjay P; Bergin, Ann M; Kothare, Sanjeev V

2010-11-01

105

Congenital chloride diarrhea misdiagnosed as pseudo-Bartter syndrome  

PubMed Central

Congenital chloride diarrhea (CCD) is a rare autosomal recessive disease which is characterized by intractable diarrhea of infancy, failure to thrive, high fecal chloride, hypochloremia, hypokalemia, hyponatremia and metabolic alkalosis. In this case report, we present the first female and the second official case of CCD in Iran. A 15-month-old girl referred to our hospital due to failure to thrive and poor feeding. She had normal kidneys, liver and spleen. Treating her with Shohl's solution, thiazide and zinc sulfate did not result in weight gain. Consequently, pseudo-Bartter syndrome was suspected, she was treated with intravenous (IV) therapy to which she responded dramatically. In addition, hypokalemia resolved quickly. Since this does not usually happen in patients with the pseudo-Bartter syndrome, stool tests were performed. Abnormal level of chloride in stool suggested CCD and she was thus treated with IV fluid replacement, Total parentral nutrition and high dose of oral omeprazole (3 mg/kg/day). She gained 1 kg of weight and is doing fine until present. CCD is a rare hereditary cause of intractable diarrhea of infancy. It should be considered in infants with unknown severe electrolyte disturbances. PMID:24381629

Saneian, Hossein; Bahraminia, Emad

2013-01-01

106

Chronic ulcerative herpes simplex virus infection of the vulva.  

PubMed

Herpes simplex virus infections in HIV-infected individuals can be clinically unusual and difficult to treat due to underlying problems with cell-mediated immunity and the occurrence of antiviral resistance. Additionally, partial or incomplete restoration of immune function may result in chronic ulcerations that require rotational treatments. In this report, we describe the case of a 38-year-old HIV-positive woman who developed the ulcerative form of chronic herpes simplex infection despite highly active antiretroviral therapy and valacyclovir prophylaxis. Repeated intravenous courses of foscarnet and topical cidofovir finally controlled her erosions as her cell-mediated immunity was slowly restored. This case highlights the challenges that still exist in diagnosing and managing this rare presentation of herpes simplex virus. PMID:23271993

Griffith-Bauer, Kelly; O'Hearn, Mary; Ehst, Benjamin D

2012-09-01

107

Aggressive angiomyxoma of the vulva: A case report.  

PubMed

Aggressive angiomyxoma (AA) is an unusual mesenchymal tumor. AA occurs most commonly in women of reproductive age and is located in the perineal or pelvic region. This is a distinct soft tissue tumor that has a prominent myxoid matrix and numerous thin-walled blood vessels and may have an aggressive local recurrence. The tumors have the characteristics of large size (usually greater than 10 cm) and slow growth, and are not painful. The standard treatment for AA is total excision and close follow-up. We announce a case of a 35 year-old female presenting with a pedunculated AA on the right labium majora that has not relapsed for seven years. PMID:24678492

Lee, Kyoung-A; Seo, Jung-Won; Yoon, Na-Ra; Lee, Jeong-Won; Kim, Byoung-Gie; Bae, Duk-Soo

2014-03-01

108

Aggressive angiomyxoma of the vulva: An uncommon entity.  

PubMed

Aggressive angiomyxoma is a rare, locally invasive mesenchymal tumor occurring usually in women of reproductive age, which carries a high risk for local relapse; hence the need to differentiate it from the other mesenchymal tumors occurring in this region. We describe a case of a 44-year-old female presenting with a large pedunculated swelling on the right labia majora. PMID:23130288

Kura, Mahendra M; Jindal, Saurabh R; Khemani, Usha N

2012-05-01

109

Aggressive angiomyxoma of the vulva: A case report  

PubMed Central

Aggressive angiomyxoma (AA) is an unusual mesenchymal tumor. AA occurs most commonly in women of reproductive age and is located in the perineal or pelvic region. This is a distinct soft tissue tumor that has a prominent myxoid matrix and numerous thin-walled blood vessels and may have an aggressive local recurrence. The tumors have the characteristics of large size (usually greater than 10 cm) and slow growth, and are not painful. The standard treatment for AA is total excision and close follow-up. We announce a case of a 35 year-old female presenting with a pedunculated AA on the right labium majora that has not relapsed for seven years. PMID:24678492

Lee, Kyoung-A; Seo, Jung-Won; Yoon, Na-Ra; Kim, Byoung-Gie; Bae, Duk-Soo

2014-01-01

110

Aggressive angiomyxoma of vulva recurring 8 years after initial diagnosis  

Microsoft Academic Search

Background  Aggressive angiomyxoma is an uncommon soft tissue tumor which preferentially involves pelvic and vulvoperineal regions of\\u000a young adult females. The typical characteristics include gelatinous appearance and locally infiltrative nature without evidence\\u000a of nuclear atypia or mitosis. Treatment involves surgery, but local recurrence is high in spite of apparently complete surgical\\u000a resection.\\u000a \\u000a \\u000a \\u000a Case  A 28-year-old woman who had had a history of

Mehmet Coskun Salman; Gamze Mocan Kuzey; Nasuh Utku Dogan; Kunter Yuce

2009-01-01

111

Recurrent aggressive angiomyxoma of the vulva - a rare presentation.  

PubMed

We describe here a case of a 38-year-old lady presenting with a about 5x4cm in size swelling on the left labia majora. She had similar type of swelling 2 years back which was treated surgically. FNAC report of the present mass revealed angiomyxoma. In view of its' recurrent nature wide local surgical excision of the mass was done. Histopathology report confirmed the diagnosis of angiomyxoma. The lady is under follow up and there is no further recurrence till date. PMID:24995218

Sengupta, Sandip Kumar; Bhattacharyya, Sanjay Kumar; Saha, Shyama Prasad; Roy, Hironmoy; Sarkar, Amarendra Nath

2014-05-01

112

Recurrent Aggressive Angiomyxoma of The Vulva – A Rare Presentation  

PubMed Central

We describe here a case of a 38-year-old lady presenting with a about 5x4cm in size swelling on the left labia majora. She had similar type of swelling 2 years back which was treated surgically. FNAC report of the present mass revealed angiomyxoma. In view of its’ recurrent nature wide local surgical excision of the mass was done. Histopathology report confirmed the diagnosis of angiomyxoma. The lady is under follow up and there is no further recurrence till date. PMID:24995218

Sengupta, Sandip Kumar; Bhattacharyya, Sanjay Kumar; Saha, Shyama Prasad; Sarkar, Amarendra Nath

2014-01-01

113

Cancer of the Vulva - SEER Stat Fact Sheets  

Cancer.gov

SEER is an authoritative source of information on cancer incidence and survival in the United States. SEER currently collects and publishes cancer incidence and survival data from population-based cancer registries covering approximately 28 percent of the U.S. population.

114

"Why do I always see double?" A misdiagnosed case of ocular myasthenia gravis for 10 years.  

PubMed

A 58-year-old man presented with diplopia and partial ptosis for 10 years. It was non-progressive in nature, despite inadequate medical attention the patient received from non-specialists/general practitioners. He did not have fatigability or diurnal variation in weakness and was clinically stable without exacerbations of disease for a decade. He did not have features of Graves's disease, oculopharyngeal dystrophy, cranial nerve paralysis, polymyositis and stroke. The possibility of an atypical presentation of myasthenia gravis (MG) was considered and the patient was evaluated. Ice pack test was negative, Cogan's lid twitch (CLT) test was positive and high titres of acetylcholine receptor antibodies (AChR Ab) suggestive of MG were found. He was treated accordingly with a very good response. PMID:24792021

Yousuf, Uduman Ali Mohamed; Yashodhara, B M; Thanigasalam, Thevi; Ting, Heng Siang

2014-01-01

115

Congenital bipartite lunate presenting as a misdiagnosed lunate fracture: a case report  

PubMed Central

Introduction A rare case of congenital bipartite lunate in a child is reported. Carpal variants are very uncommon as independent entities, with only three previous reports of this condition in the English literature. Case presentation An 11-year-old Caucasian boy presented with pain in the left wrist after a fall. Radiographs in the emergency department demonstrated a lunate that was divided into palmar and dorsal parts, causing a misdiagnosis of fractured lunate. Magnetic resonance imaging was then used to differentiate between the two diagnoses. Conclusion Very few cases of bipartite lunate have been reported in the literature, and unless awareness is raised about congenital anomalies such as this variant, confusion may arise. PMID:21401931

2011-01-01

116

Mucinous cystadenoma of the appendix misdiagnosed as cystic hydatid disease of the liver: a case report  

Microsoft Academic Search

INTRODUCTION: Primary neoplastic lesions presenting with a mucocele of the appendix are very rare and can be divided into benign variants of mucinous adenomas or cystadenomas, mucinous tumours of uncertain malignant potential or mucinous cystadenocarcinomas. Most of these tumourous mucoceles are asymptomatic and are found incidentally. The major complication of neoplastic mucinous appendiceal tumours is the development of a pseudomyxoma

Andreas Krieg; Jan Schulte am Esch; Ludger W Poll; Stefan Braunstein; Wolfram T Knoefel

2008-01-01

117

Longstanding Hypoparathyroidism in a Fifty-Two-Year-Old Woman Misdiagnosed as Spondyloarthropathy  

PubMed Central

Introduction: Hypoparathyroidism might cause various musculoskeletal findings, resembling Spondyloarthropathies. Case Presentation: We described a 52-year-old woman, diagnosed as a case of undifferentiated spondyloarthropathy for ten years, who was unresponsive to classic anti-inflammatory therapies. She developed anterior ischemic optic neuropathy and had elevated muscle enzymes during the course of disease. On a routine checkup, marked hypocalcemia and suppressed parathyroid hormone levels were found. Calcium and calcitriol therapy led to clinical and laboratory improvement. Conclusions: This case emphasizes the importance of recognizing rheumatic manifestations of hypoparathyroidism to preclude unnecessary treatments. Serum calcium should be included in the diagnostic workup of these patients.

Zabihiyeganeh, Mozhdeh; Jahed, Seyed Adel; Akbari, Hounaz

2014-01-01

118

Pharmacoresistant partial-onset epilepsy misdiagnosed as panic disorder: a case report.  

PubMed

The clinical differentiation between simple partial epileptic seizures of temporal lobe origin and panic attacks is often difficult on clinical grounds alone, because both conditions are characterized by common symptomatology which includes the feeling of fear, autonomic system dysfunction, disorientation and alternation of the level of consciousness when these conditions evolve clinically. The symptoms stem from common pathophysiologic and anatomic substrates of these two conditions, localized in the limbic system, especially the amygdala. We present the case of a young woman who had a febrile seizure in childhood and subsequent episodes of fear accompanied by tremor and possible alteration of consciousness followed by headache. These spells were diagnosed as panic attacks during her teenage years and she was given Clobazam in order to suppress them. The patient responded well for several years without attacks but her symptoms reappeared following discontinuation of her medication in order to conceive. At that time a detailed history was taken from her spouse and further clinical evaluation raised the suspicion of seizures especially due to the fact that her spells were characterized by alteration of consciousness; she was therefore referred for additional investigations which included admission to a monitoring unit for epilepsy. Long-term video-EEG recording revealed the presence of simple partial seizures with secondary generalization confirming the clinical impression. She was subsequently treated with antiepileptic medications; however the patient's condition worsened to the point where she became pharmacoresistant having failed several antiepileptic drug trials in monotherapy or combination. An MRI scan of the brain revealed the presence of right-sided mesial temporal sclerosis, a known consequence of febrile seizures. Her seizures were nocturnal tonic-clonic and gradually worsened to the point of occurring during most nights. She was therefore referred for a presurgical evaluation which confirmed that the epileptic focus was associated with the area of mesial temporal sclerosis. The epileptic focus was successfully removed from the right anterior temporal lobe and since then she remained free of seizures whereas, in addition, the presumed symptoms of panic attacks also resolved. This case indicates the occasional difficulty in diagnosing simple partial seizures and how it may be confused with psychiatric conditions. Therefore, the treating physician, especially the psychiatrist, should remain vigilant when treating cases of panic attacks, especially when they present with either atypical symptomatology, such as the case described, or when they do not respond to appropriately chosen treatment; such cases may warrant referral for further investigation. PMID:25367666

Papacostas, S S; Myrianthopoulou, P; Georgiades, S; Papathanasiou, E S

2014-01-01

119

A case of intradural-extramedullary form of primary spinal cysticercosis misdiagnosed as an arachnoid cyst.  

PubMed

We describe a rare case of intradural-extramedullary primary spinal cysticercosis. A 42-year-old man visited our institute for lower back pain. He denied having consumed raw meet. Magnetic resonance (MR) images revealed an intradural pure cystic mass at the L3-L4 level. A radiologic diagnosis of spinal arachnoid cyst was established. Three years later, he complained of aggravated back pain, and follow-up MR examination showed a markedly expanded cyst, occupying the subarachnoid space from the T11 to the S1 level. L2 hemilaminectomy was performed, and a yellowish infected cyst bulged out through the dural opening. The cyst was removed en bloc. The histopathological findings of the cyst were consistent with parasitic infection. Serum enzyme-linked immunosorbent assay (ELISA) confirmed the presence of spinal cysticercosis. As there was no intracranial lesion, the final diagnosis was primary spinal cysticercosis, which is very rare. MR imaging is a sensitive diagnostic tool for detecting cystic lesions in the spine; however, it is difficult to distinguish cysticercosis from non-infectious cysts such as an arachnoid cyst without using gadolinium enhancement. Clinicians treating spinal cysts with an unusual clinical course should include cysticercosis as a differential diagnosis. We recommend contrast-enhanced MR imaging and serum ELISA in the diagnostic work-up of such cases. PMID:25024830

Yoo, Minwook; Lee, Chang-Hyun; Kim, Ki-Jeong; Kim, Hyun-Jib

2014-04-01

120

Hereditary diffuse leukoencephalopathy with axonal spheroids (HDLS): a misdiagnosed disease entity  

PubMed Central

Hereditary diffuse leukoencephalopathy with spheroids (HDLS) was originally described in a large Swedish pedigree. Since then, 22 reports describing a total of 13 kindred's and 11 sporadic cases have been published. Inheritance is autosomal dominant, albeit the gene is unknown. Here we report on the clinical findings, genealogical data, brain MRI data, and autopsy/biopsy findings of four probands from three independently ascertained novel families from Norway, Germany and US. We identified a 39-year-old female and her twin sister, a 52-year-old male and a 47-year-old male with progressive neurological illness characterized by personality changes, cognitive decline and motor impairments, such as gait problems, bradykinesia, tremor and rigidity. Brain MRI showed white matter abnormalities with frontal prominence. Brain biopsy/autopsies were consistent with HDLS. HDLS is an under-recognized disease and in reporting these cases, we aim to increase the awareness of the disorder. Due to varied and wide phenotypic presentations, which may imitate several neurodegenerative diseases, HDLS can be difficult to diagnose. Definitive diagnosis can be established only by direct brain tissue examination. Familiarity with the clinical presentation and typical neuroimaging findings may be helpful in narrowing the diagnosis. PMID:22050953

Sundal, Christina; Lash, Jennifer; Aasly, Jan; ygarden, Sarka Ř; Roeber, Sigrun; Kretzschman, Hans; Garbern, James Y.; Tselis, Alex; Rademakers, Rosa; Dickson, Dennis W.; Broderick, Daniel; Wszolek, Zbigniew K.

2011-01-01

121

Group A Streptococci: A rare and often misdiagnosed cause of spontaneous bacterial peritonitis in adults  

PubMed Central

Introduction Acute primary peritonitis due to group A Streptococci (GAS) is a rare but life-threatening infection. Unlike other forms of primary peritonitis it affects predominantly young previously healthy individuals and thus is often confused with the more frequent secondary peritonitis. A case series of three patients is presented as well as a review of the literature focusing on pitfalls in the diagnose and therapy of GAS peritonitis. Methods A retrospective analysis of three patients with primary GAS peritonitis was performed. Furthermore a systematic review of all cases of primary GAS peritonitis published from 1990 to 2013 was performed comparing demographics and clinical presentation, as well as radiological imaging, treatment and outcome. Results All three female patients presented initially with high fever, nausea and severe abdominal pain. Radiological imaging revealed intraperitoneal fluid collections of various degrees, but no underlying cause of peritonitis. Broad antibiotic treatment was started and surgical exploration was performed for acute abdomen in all three cases. Intraoperatively fibrinous peritonitis was observed, but the correct diagnosis was not made until microbiological analysis confirmed GAS peritonitis. One patient died within 24 h after admission. The other two patients recovered after multiple surgeries and several weeks on the intensive care unit due to multiple organ dysfunction syndrome. The fulminant clinical course of the three patients resembled those of many of the published cases: flu-like symptoms, high fever, severe acute abdominal pain and fibrinous peritonitis without obvious infectious focus were the most common symptoms reported in the literature. Conclusion GAS primary peritonitis should be considered in particular in young, previously healthy women who present with peritonitis but lack radiological findings of an infectious focus. The treatment of choice is immediate antibiotic therapy. Surgical intervention is difficult to avoid, since the diagnosis of GAS peritonitis is usually not confirmed until other causes of secondary peritonitis have been excluded. PMID:25555146

Malota, Mark; Felbinger, Thomas W.; Ruppert, Reinhard; Nüssler, Natascha C.

2014-01-01

122

To avoid misdiagnoses and unnecessary care, take the time to engage patients, listen to their concerns.  

PubMed

Despite time constraints and other pressures, emergency personnel can improve both outcomes and patient satisfaction by taking the time to engage patients in decisions about their care, according to Leana Wen, MD, MSc, an emergency medicine physician and the director of Patient-Centered Care Research at George Washington University in Washington, DC. Wen has written a book aimed at helping patients advocate for themselves, but she also notes that many emergency providers could be doing a better job of asking patients about their concerns. Wen advises nurses and other emergency staff to prompt patients to organize their thoughts and preparequestions while they are waiting to see the provider. She also urges providers to explain to patients why they are doing certain tests or procedures. This can help providers avoid unnecessary steps, and to formulate a better plan of care. With respect to patient satisfaction, Wen acknowledges that some patients maynot be happy when they are denied antibiotics or other care thatthey are requesting, but she notes that such concerns are usually assuaged when providers take the time to explain why the requested test or prescription is not advisable. PMID:25793252

2015-03-01

123

A Case of Misdiagnosed Cesarean Scar Pregnancy with a Viable Birth at 28 Weeks  

PubMed Central

We report our experience with a case of presumptive cesarean scar pregnancy, based on detection of a gestational sac (GS) in early pregnancy at the site of a previous cesarean scar. The GS grew into the uterine cavity as the pregnancy progressed, showing an ultrasound image similar to that of a normal pregnancy. Thus, the pregnancy continued, resulting in a viable birth at 28 weeks of gestation. Cesarean scar pregnancy is classified as myometrial implantation or implantation growth into the uterine cavity. In the latter type, the gestational sac moves upward with increasing gestational weeks and it shows the same ultrasound image as a normal pregnancy. Therefore, the diagnosis must be made in the early pregnancy. PMID:25371837

Nukaga, Sakiko; Aoki, Shigeru; Kurasawa, Kentaro; Takahashi, Tsuneo; Hirahara, Fumiki

2014-01-01

124

Insufficiency fractures of the distal tibia misdiagnosed as cellulitis in three patients with rheumatoid arthritis  

SciTech Connect

We describe 3 patients with rheumatoid arthritis who presented with diffuse pain, swelling, and erythema of the distal aspect of the lower extremity, suggestive of either cellulitis or thrombophlebitis, but were found to have insufficiency fractures of the distal tibia. The value of technetium-99m diphosphonate bone scintigraphy in the early recognition of these fractures and a possible explanation for the associated inflammatory symptoms are discussed.

Straaton, K.V.; Lopez-Mendez, A.; Alarcon, G.S. (Univ. of Alabama, Birmingham (USA))

1991-07-01

125

Acute intermittent porphyria caused by novel mutation in HMBS gene, misdiagnosed as cholecystitis  

PubMed Central

Background Acute intermittent porphyria (AIP) is an autosomal dominant neurovisceral inherited disorder due to a defect in the heme biosynthesis pathway. Misdiagnosis of the porphyrias is not uncommon. Case report We present a case of a 26-year-old female with suspected acute cholecystitis, mental status changes, and seizures. Biochemical and molecular investigations confirmed the diagnosis of AIP by findings of elevated urinary porphobilinogen, 5-aminolevulinic acid, and total porphyrins. DNA molecular testing showed a novel heterozygous mutation (c. 760delC p.L254X) in the exon11 of the HMBS gene. To the best of our knowledge, this is the first report of a misdiagnosis of AIP presenting with acute cholecystitis. Conclusion Clinicians are alerted to consider the possibility of AIP in an adult presenting with an acute abdomen, features of cholecystitis, and neuropsychiatric manifestations. PMID:25419136

Alfadhel, Majid; Saleh, Neam; Alenazi, Helal; Baffoe-Bonnie, Henry

2014-01-01

126

Delayed Surgery for Parathyroid Adenoma Misdiagnosed as a Thyroid Nodule and Treated with Radiofrequency Ablation  

PubMed Central

Primary hyperparathyroidism occurs as a result of isolated parathyroid adenoma in 80% to 85% of all cases. A 99mtechnetium (99mTc) sestamibi scan or neck ultrasonography is used to localize the neoplasm prior to surgical intervention. A 53-year-old female was referred for the exclusion of metabolic bone disease. She presented with low back pain that had persisted for the past 6 months and elevated serum alkaline phosphatase (1,253 IU/L). Four years previously, she had been diagnosed at a local hospital with a 2.3-cm thyroid nodule, which was determined to be pathologically benign. Radiofrequency ablation was performed at the same hospital because the nodule was still growing during the follow-up period 2 years before the visit to our hospital, and the procedure was unsuccessful in reducing the size of the nodule. The results of the laboratory tests in our hospital were as follows: serum calcium, 14.6 mg/dL; phosphorus, 3.5 mg/dL; and intact parathyroid hormone (iPTH), 1,911 pg/mL. Neck ultrasonography and 99mTc sestamibi scan detected a 5-cm parathyroid neoplasm in the left lower lobe of the patient's thyroid; left parathyroidectomy was performed. This case indicated that thyroid ultrasonographers and pathologists need to be experienced enough to differentiate a parathyroid neoplasm from a thyroid nodule; 99mTc sestamibi scan, serum calcium, and iPTH levels can help to establish the diagnosis of parathyroid neoplasm. PMID:24396684

Kim, Ho-Su; Choi, Bong Hoi; Park, Jung Rang; Hahm, Jong Ryeal; Jung, Jung Hwa; Kim, Soo Kyoung; Kim, Sungsu; Kim, Kyong-Young; Chung, Soon Il

2013-01-01

127

[Misdiagnosed PTSD and zeldox pharmacotherapy in case of a political prisoner].  

PubMed

Treatment of survivors of political terror is an emerging and difficult field. Reports on posttraumatic stress disorder (PTSD) in political prisoners within the former Eastern Block countries is low and mostly restricted to German sources. During the totalitarian period administrative and clinical decisions often had to take into account political realities not found in other treatment environments. That practice might have lead to biased professional training, lack of experience extending into the post-communist era and leading to current underpresentation of PTSD. The authors present a case report of a Hungarian political prisoner with long history of PTSD who had a "carry over" diagnosis of paranoid schizophrenia even 15 years after the collapse of the communist regime. After decades of continuous administration of antipsychotic and antidepressive medications, either alone or in combination, Zeldox monotherapy has proven to be the most effective treatment for this patient. PMID:15825678

Frecska, Ede; Keresztes, Mária; Gaszner, Gábor

2004-12-01

128

A girl with steroid cell ovarian tumor misdiagnosed as non-classical congenital adrenal hyperplasia.  

PubMed

Ovarian steroid cell tumors are rarely encountered in prepubertal girls. The majority of these tumors produce hormones, testosterone being the leading one. These tumors may either coexist with or imitate congenital adrenal hyperplasia (CAH). We present a 13-year-old female patient who was diagnosed with non-classical CAH at six years of age while being investigated for premature pubarche. She was diagnosed with steroid cell ovarian tumor after a delay of six years. The diagnosis was based on radiologic imaging, which was performed to investigate causes of unsuccessful metabolic control while under high-dose steroid therapy. The right ovarian hypoechoic mass of 23x22 mm was excised laparoscopically, preserving the ovary. Immunohistochemical staining showed that tumor cells were strongly positive with inhibin and focally positive with vimentin. Based on these findings, the patient was diagnosed with ovarian steroid cell tumor not otherwise specified. In the postoperative second week, total testosterone level was <10 ng/ml, and 17 hydroxyprogesterone (17-OHP) level was 1.1 ng/ml. Peak 17-OHP level was 4.2 ng/ml on repeated ACTH stimulations, and the diagnosis of CAH was excluded. Steroid therapy was tapered down and then discontinued. It should be kept in mind that there may be a misdiagnosis in cases of CAH, which may present itself with unsuccessful metabolic control even while under the appropriate treatment dose. Early diagnosis and treatment would prevent the development of irreversible signs. PMID:24292042

Y?lmaz-A?lad?o?lu, Sebahat; Sava?-Erdeve, ?enay; Boduro?lu, Esin; Önder, A?an; Karaman, ?brahim; Çetinkaya, Semra; Aycan, Zehra

2013-01-01

129

Congenital mitral valve regurgitation in adult patients. A rare, often misdiagnosed but repairable, valve disease  

Microsoft Academic Search

Objective: Congenital mitral valve regurgitation (MVR) is a rare disease occurring in infancy or childhood. Although congenital MVR has been described in adults, no surgical series has been reported so far. We describe here a 6-year surgical experience of congenital MVR in adults at a single institution. Methods: We reviewed the data of 15 consecutive patients (8 men), aged more

Rachid Zegdi; Brahim Amahzoune; Mustapha Ladjali; Ghassan Sleilaty; Jérome Jouan; Christian Latrémouille; Alain Deloche; Jean-Noël Fabiani

2008-01-01

130

Condyloma-like squamous cell carcinoma of the vulva: report of two midline cases.  

PubMed

Vulvar cancer is uncommon and may be confused with genital condylomata. We report two cases of middle-aged women presenting with exophytic vulvar tumors of the midline for which diagnosis of a vulvar squamous cell carcinoma was confirmed by histopathology. Risk factors, staging, and treatment options are discussed. PMID:23055761

Verma, Shyam B; Wollina, Uwe

2012-01-01

131

Condyloma-like squamous cell carcinoma of the vulva: report of two midline cases  

PubMed Central

Vulvar cancer is uncommon and may be confused with genital condylomata. We report two cases of middle-aged women presenting with exophytic vulvar tumors of the midline for which diagnosis of a vulvar squamous cell carcinoma was confirmed by histopathology. Risk factors, staging, and treatment options are discussed. PMID:23055761

Verma, Shyam B; Wollina, Uwe

2012-01-01

132

Aggressive angiomyxoma of the vulva: a case report and review of literature  

Microsoft Academic Search

Background  Aggressive angiomyxoma (AA) is a rare vulvovaginal mesenchymal neoplasm with a marked tendency to local recurrence but which\\u000a usually does not metastasize.\\u000a \\u000a \\u000a \\u000a Case report  We describe a case of AA in the left labium majus pudendi in a 47-year-old woman who underwent incomplete surgical excision.\\u000a Follow-up 2 years later revealed no recurrence.\\u000a \\u000a \\u000a \\u000a Conclusion  In the past, most authors advocated wide excision even if

Inge Dierickx; Karen Deraedt; Willy Poppe; Jasper Verguts

2008-01-01

133

Aggressive angiomyxoma of the vulva: Dramatic response to gonadotropin-releasing hormone agonist therapy  

Microsoft Academic Search

Background.Aggressive angiomyxoma (AA) is a vulvovaginal mesenchymal neoplasm with a marked tendency to local recurrence but which usually does not metastasise. Most cases exhibit positive immunohistochemical staining with oestrogen receptor (ER) and, or, progesterone receptor (PR).

W. G. McCluggage; T. Jamieson; S. P. Dobbs; A. Grey

2006-01-01

134

Primary human herpesvirus-6 and -7 infections, often coinciding, misdiagnosed as measles in children from a tropical region of Brazil.  

PubMed Central

We investigated primary human herpesvirus-6 and -7 (HHV-6, HHV-7) infections as a cause of rashes incorrectly diagnosed as measles in Brazilian children. Sera from 124 patients, aged 4 months to 17 years, from the states of Rio de Janeiro and Espirito Santo, in whom measles, rubella and parvovirus B19 infections had been excluded, were studied using indirect immunofluorescence antibody avidity tests; 38 (31%) had evidence of primary HHV-6 and/or HHV-7 infections. Twenty four children had primary HHV-6 infection, either recent or coincident with the rash, and similarly 31 had primary HHV-7 infection. Remarkably, almost half (17) of primary infections were dual HHV-6 and HHV-7 infections with the majority, 12 (71%), in children less than 1 year old. HHV-7 infection occurred earlier than previously reported, perhaps due to socioeconomic and tropical conditions in this region of Brazil, and thus coincided with the HHV-6 infections. This study also highlights the difficulties of diagnosing a rash illness on clinical grounds alone. PMID:14596528

Oliveira, S. A.; Turner, D. J.; Knowles, W.; Nascimento, J. P.; Brown, D. W. G.; Ward, K. N.

2003-01-01

135

Misdiagnosed pneumothorax interpreted as necrotizing fasciitis of the chest wall: case report of a potentially preventable death  

PubMed Central

Background Subcutaneous emphysema is an uncommon clinical finding associated both with benign sources and potentially deadly necrotizing infections. Wide ranges of causes exist including trauma, iatrogenic injuries, factitious disorders and necrotizing infections. Case presentation A 49-year old male presented to the emergency room with extensive subcutaneous emphysema following blunt trauma. The orthopaedic surgery service was consulted for treatment of suspected necrotizing fasciitis due to his subcutaneous emphysema. A careful patient history and physical examination correlated with laboratory and radiographic findings revealed rib fractures and a long-standing, undiagnosed pneumothorax as the cause for emphysema. Treatment of the underlying condition with chest tubes led to eventual resolution of the emphysema, though multisystem organ failure ultimately resulted in patient death. Conclusion This case illustrates the importance of rapidly and appropriately evaluating trauma patients, and in this case specifically diagnosing and treating the underlying cause of subcutaneous emphysema. The late diagnosis of pneumothorax resulted in delayed definitive treatment, which may have contributed to the patient’s ultimate demise. In acute and sub-acute trauma situations a high level of suspicion for life threatening injuries must be maintained. Decision making for initial treatment should be based on the basic tenants of Advanced Trauma Life Support to primarily address these injuries and help prevent further disability or death. PMID:24834125

2014-01-01

136

Unbalanced interchromosomal insertion diagnosed prenatally by FISH, with carrier mother, previously misdiagnosed as having a balanced reciprocal translocation  

SciTech Connect

Insertion translocations are rare. A carrier with a balanced insertion translocation is most likely to be detected through offspring with an unbalanced translocation. We with to report a case where a correct diagnosis, made prenatally with FISH, corrected the initial misdiagnosis of the mother in another institute. PDL received an amniotic fluid sample from a 28 y.o. woman (G5P2Sab1TOP1) at 19 wks gestation. The indications were a reported balanced translocation, t(6;13), in the mother and a previous daughter with an unbalanced translocation. Chromosome analysis of the amniocytes showed a female karyotype with an abnormal chr. 13. Since the mother was diagnosed as having t(6;13)(q21;q34), the der(13) in the amniocytes was initially assumed to result from an adjacent segregation of the t(6;13). However, the banding patterns of this abnormal chr. 13 did not fit into the above defined translocation. With FISH and a chr. 13 painting probe, this der(13) was painted in the proximal and the distal thirds, but NOT in the middle region. This indicates that the middle section of the der(13) must have originated from 6q. The banding pattern is compatible with a direct insertion of 6q15 to 6q23.3 into 13q21.2. Thus, the fetus has partial trisomy 6q. After counseling, the mother elected to terminate the pregnancy but later changed her mind. An 8 lb 12 oz baby girl was born at 36 wks. (mother diabetic). Chromosome analysis of the newborn blood confirmed the dx. The mother was studied, using multicolor painting probes for chromosomes 13 and 6, a balanced direct insertion of 6q15 to 6q23.3 into chr. 13q21.2 was clearly shown. The previous affected daughter with a 13q+ is now 4 y.o. (a restudy is planned). She has microcephaly, severe developmental delay and other dysmorphic features. This case illustrates the advantage of using FISH to arrive at a definitive diagnosis of an insertion translocation.

Yu, M.T.; Leiber, E.; Qazi, Q. [and others

1994-09-01

137

Trisomy 7 mosaicism prenatally misdiagnosed and maternal uniparental disomy in a child with pigmentary mosaicism and Russell- Silver syndrome.  

PubMed

Prenatal diagnosis of true mosaic trisomy 7 is rare in amniotic fluid and can be misinterpreted as pseudomosaic. The phenotype is highly variable and may be modified by a maternal uniparental disomy of chromosome 7 leading to mild Russell-Silver syndrome (RSS). We report here the third postnatal case of mosaic trisomy 7 with maternal uniparental disomy of chromosome 7 in a boy presenting a mild RSS. Fetal karyotype performed in amniocentesis for intrauterine growth retardation was considered normal. Mosaic trisomy 7 was diagnosed after birth, on fibroblasts karyotype performed for blaschkolinear pigmentary skin anomalies and failure to thrive. Maternal uniparental disomy of chromosome 7 was observed in blood sample. Retrospectively, trisomic 7 cells were identified in one prenatal long-term flask culture revealing a prenatal diagnosis failure. This report emphasizes the difficulty of assessing fetal mosaicism and distinguishing it from pseudomosaicism in cultured amniocytes. It is important to search for uniparental disomy as an indirect clue of trisomy 7 mosaicism and a major prognosis element. Although there are only few prenatal informative cases, detection of trisomy 7 in amniocentesis appears to be associated with a relatively good outcome when maternal uniparental disomy has been ruled out. PMID:21204802

Petit, F; Holder-Espinasse, M; Duban-Bedu, B; Bouquillon, S; Boute-Benejean, O; Bazin, A; Rouland, V; Manouvrier-Hanu, S; Delobel, B

2012-03-01

138

Aggressive angiomyxoma of the vagina: a case report.  

PubMed

Aggressive angiomyxoma is a rare, slow-growing soft tissue tumor that usually arises in the pelvis and perineal regions of women in reproductive age, with a marked tendency to local recurrence. Because of its rarity, it is often initially misdiagnosed. Surgical resection is the main treatment modality of aggressive angiomyxoma. We describe a case of a vaginal aggressive angiomyxoma in a 47-year-old woman in which the diagnosis was only made after histological examination. The etiology, presentation, diagnosis and management of this rare tumor are outlined. Angiomyxoma of vulva and vagina refers to a rare disease. Pre-operative diagnosis is difficult due to rarity and absence of diagnostic features, but it should be considered in every mass in genital, perianal and pelvic region in a woman in the reproductive age. Thus, these cases should have complete radiological workup before excision, as pre-diagnosis can change the treatment modality and patient prognosis'. PMID:24500513

Lourenço, Cátia; Oliveira, Nuno; Ramos, Filomena; Ferreira, Isabel; Oliveira, Mário

2013-12-01

139

Aggressive angiomyxoma: swirled configuration on ultrasound and MR imaging.  

PubMed

Aggressive angiomyxoma is a rare, myofibroblastic tumour, of pelvi-perineum of young women. It is a slow growing, low grade neoplasm with a high risk of recurrence following initial resection. Aggressive angiomyxoma is often clinically misdiagnosed because of its variable presentation as a soft tissue mass of the vulva, perianal region, buttock or pelvis. It displays translevator extension with growth around the perineal structures. Fewer than 150 cases have been reported in the literature since 1983. Imaging is important to determine the extent of the lesion. We present layered configuration of the mass on ultrasound and Magnetic Resonance Imaging in a 40 years old woman with a left pelvi- perineal mass since 5 years. Histapathology after excision gave a diagnosis of Aggressive Angiomyxoma. PMID:24864615

Tariq, Rukhsana; Hasnain, Shehla; Siddiqui, Maria Tariq; Ahmed, Rashid

2014-03-01

140

Primary Medical Management of Recurrent Aggressive Angiomyxoma of the Vulva with a Gonadotropin-Releasing Hormone Agonist  

Microsoft Academic Search

Background. An aggressive angiomyxoma of the pelvis is a locally infiltrative lesion treated with wide local excision. Recurrence is common. A potential medical treatment alternative is reported.Case. A 34-year-old woman presented with her second recurrence of a vulvar angiomyxoma following two prior surgical excisions. Analysis of the recurrent tumor for estrogen and progesterone receptors was strongly positive. The patient was

Bruce A. Fine; Alan K. Munoz; Craig E. Litz; David M. Gershenson

2001-01-01

141

Is Bilateral Lymphadenectomy For Midline Squamous Carcinoma Of The Vulva Always Necessary? An Analysis From Gynecologic Oncology Group (GOG) 173  

PubMed Central

Objective To determine which patients with near midline lesions may safely undergo unilateral groin dissection based on clinical exam and lymphoscintigraphy (LSG) results. Methods Patients participating in GOG-173 underwent sentinel lymph node (SLN) localization with blue dye, and radiocolloid with optional LSG before definitive inguinal-femoral lymphadenectomy (LND). This analysis interrogates the reliability of LSG alone relative to primary tumor location in those patients who had an interpretable LSG and at least one SLN identified. Primary tumor location was categorized as lateral (>2 cm from midline), midline, or lateral ambiguous (LA) if located within 2 cm., but not involving the midline. Results Two-hundred-thirty-four patients met eligibility criteria. Sixty-four had lateral lesions, and underwent unilateral LND. All patients with LA (N=65) and midline (N=105) tumors underwent bilateral LND. Bilateral drainage by LSG was identified in 14/64 (22%) patients with lateral tumors, 38/65 (58%) with LA tumors and in 73/105 (70%) with midline tumors. At mapping, no SLNs were found in contralateral groins among those patients with LA and midline tumors who had unilateral-only LSGs. However, in these patients groin metastases were found in 4/32 patients with midline tumors undergoing contralateral dissection; none were found in 27 patients with LA tumors. Conclusion The likelihood of detectable bilateral drainage using preoperative LSG decreases as a function of distance from midline. Patients with LA primaries and unilateral drainage on LSG may safely undergo unilateral SLN. PMID:23201592

Coleman, Robert L.; Ali, Shamshad; Levenback, Charles F.; Gold, Michael A.; Fowler, Jeffrey M.; Judson, Patricia L.; Bell, Maria C.; De Geest, Koen; Spirtos, Nick M.; Potkul, Ronald K.; Leitao, Mario M.; Bakkum-Gamez, Jamie N.; Rossi, Emma C.; Lentz, Samuel S.; Burke, James J.; Van Le, Linda; Trimble, Cornelia L.

2013-01-01

142

Sodium Tetradecyl Sulphate Direct Intralesional Sclerotherapy of Venous Malformations of the Vulva and Vagina: Report of Five Cases  

SciTech Connect

We report five cases of female patients affected by symptomatic focal external genital venous malformations treated with percutaneous direct intralesional injection of sodium tetradecyl sulphate (STS). All patients were referred because of discomfort and pain when sexual intercourse was attempted. Direct sclerotherapy with 3% STS was performed on a day-hospital basis with the patient under local anesthesia. Complete resolution of the symptoms was achieved in all cases. No major adverse effects were reported. Direct intralesional sclerotherapy with STS may be considered a safe and effective method for the treatment of female external genital malformation without the necessity of general anesthesia for pain control.

Krokidis, Miltiadis, E-mail: mkrokidis@hotmail.com [Guy's and St. Thomas' NHS Trust, Department of Radiology (United Kingdom); Venetucci, Pietro [University Hospital 'Federico II', Department of Cardiovascular and Interventional Radiology (Italy); Hatzidakis, Adam [Medical School of Crete (Greece); Iaccarino, Vittorio [University Hospital 'Federico II', Department of Cardiovascular and Interventional Radiology (Italy)

2011-02-15

143

Children with Disabilities Are Often Misdiagnosed Initially and Children with Neuropsychiatric Disorders Are Referred to Adequate Resources 30 Months Later than Children with Other Disabilities  

ERIC Educational Resources Information Center

Disabilities in a child may lead to low self-esteem and social problems. The lives of parents and siblings are also affected. Early intervention may decrease these consequences. To promote early intervention early referral to adequate resources is essential. In a longitudinal retrospective observational study it was found that children with…

Tuominen-Eriksson, Alli-Marie; Svensson, Yvonne; Gunnarsson, Ronny K.

2013-01-01

144

Femur chondrosarcoma misdiagnosed as acute knee arthritis and osteomyelitis--further developing a hitherto unreported complication of tumor embolic ischemic ileal perforation after arthroscopic lavage.  

PubMed

The differentiation between osteomyelitis and bone tumor may be difficult due to their overlapping clinical and radiological features. A 25-year-old lady presented with left knee pain and joint effusion associated with redness and hotness. A sub-optimally taken plain radiograph showed mixed osteolytic and osteoblastic lesion in the left lower femur with surrounding soft tissue swelling. Since the clinical diagnosis was acute osteomyelitis and arthritis, arthroscopic lavage was performed as a diagnostic and therapeutic procedure. The removed loose bodies and fibrinous tissue showed pathological features suspicious of chondrosarcoma. Subsequent MRI revealed an infiltrative tumor eroding through the cortex and joint cartilage. En bloc excision of the left lower femur, upper tibia including the knee joint and patella was performed, and the final diagnosis was grade 2 chondrosarcoma. The patient developed bilateral pulmonary metastasis 33 months after operation. Five months later, she suffered from a hitherto undescribed complication of ischemic perforation of the terminal ileum secondary to tumor embolic arterial obstruction with no macroscopic intestinal or peritoneal tumor deposit. The patient developed multiple brain metastases and died 43 months after initial presentation. Our case illustrates that malignant bone tumor as a differential diagnosis of acute osteomyelitis and arthritis merits recognition and exclusion before arthroscopic lavage, which may enhance tumor dissemination and in our patient results in embolic ischemic ileal perforation. PMID:25242025

Chow, Louis Tsun Cheung

2014-12-01

145

Primary pulmonary amyloidosis misdiagnosed as malignancy on dual-time-point fluoro-deoxyglucose positron emission tomography/computed tomography: A case report and review of the literature  

PubMed Central

Primary pulmonary amyloidosis is an uncommon manifestation, characterized by amyloid deposition in the lungs and other associated tissue. The clinical presentation of amyloidosis is variable, with non-specific symptoms. The current study reports the case of a 59-year-old female presenting with primary pulmonary amyloidosis, indistinguishable from lung malignancy based on 18F-fluoro-deoxyglucose (18F-FDG) accumulation on dual-time-point (DTP) FDG-positron emission tomography/computed tomography (PET/CT) imaging and the similarities in morphological changes. A percutaneous CT-guided thoracoscopic biopsy was subsequently performed. Histological examination revealed that the specimens contained amorphous, homogeneous material with a number of polyclonal plasma cells, lymphocytes and giant cells. A diagnosis of primary nodular parenchymal pulmonary amyloidosis was determined, and the patient was discharged without chemotherapy. The patient remained in good clinical condition during follow-up. The present case indicated that localized nodular amyloidosis with increased FDG uptake on DTP FDG PET must be considered in the differential diagnosis of growing lung nodules, and that a histological examination must be conducted to distinguish this condition from malignancies of the lung. PMID:25624887

DONG, MENG-JIE; ZHAO, KUI; LIU, ZHEN-FENG; WANG, GUO-LIN; YANG, JUN

2015-01-01

146

Phosphatidylglycerol determination in the amniotic fluid from a PAD placed over the vulva: a method for diagnosis of fetal lung maturity in cases of premature ruptured membranes.  

PubMed

Four hundred and forty seven pregnant women with ruptured membranes, were prospectively studied in order to assess the diagnostic capacity of Phosphatidylglycerol (PhG) determination in amniotic fluid recovered from vulval pads in the diagnosis of Hyaline Membrane Disease (HMD). The identification of PhG was performed using one dimensional silica gel thin layer chromatography. The sensitivity of PhG determination in the diagnosis of HMD in newborns of the total population was found to be 88.2%, with a specificity of 76.9%. In the study population, the incidence of HMD was 7.6%, the negative predictive value was 98.8% and, the positive predictive value was 24.0%. When the 265 newborns of the gestational age group of less than or equal to 34 weeks is considered, we observed an incidence of HMD of 12.1%. The diagnostic capacity of PhG in this group was shown by a sensitivity of 87.5%, a specificity of 76.4%, a positive predictive value of 33.7% and a negative predictive value of 97.8%. This method of assessment of fetal lung maturity has a diagnostic capability similar to that described by other authors, who used amniotic fluid obtained vaginally or transabdominally. The procedure described here of amniotic fluid collection is non-invasive, harmless to the mother and fetus and simple to perform. The characteristics of this method, allow serial studies of the amniotic fluid to be carried out. PMID:1608026

Estol, P C; Poseiro, J J; Schwarcz, R

1992-01-01

147

Does long-term follow-up have a role for node negative squamous carcinoma of the vulva? The Gateshead experience.  

PubMed

A retrospective review was performed of 138 cases of squamous vulval cancer referred to Gateshead between 1986 and 1997, with a median follow-up of 48 months. Eighteen recurrences were detected, 11 within one year of surgery. All nine patients with groin/distant recurrence (including 4 presenting initially with local recurrence only) died of vulval cancer. Vulval pain, bleeding or other symptoms heralded all recurrences. Routine review was ineffective in detecting recurrence. Eight cases were detected by general practitioners, three by specialists, and one was self-diagnosed. Six of these had had clinical review less than two months previously. Follow-up does not appear to offer early detection or survival advantages. Patient education, with symptom-triggered rapid clinic access, may be more effective. Prospective research is indicated to assess both the effectiveness and psychological implications of routine follow-up and alternative strategies. PMID:11321491

Nordin, A; Mohammed, K A; Naik, R; de Barros Lopes, A; Monaghan, J

2001-01-01

148

Wnt and EGF pathways act together to induce C. elegans male hook development  

E-print Network

Comparative studies of vulva development between Caenorhabditis elegans and other nematode species have provided some insight into the evolution of patterning networks. However, molecular genetic details are available ...

Sternberg, Paul W.

149

Oviposition Process of Solenopsis invicta (Hymenoptera: Formicidae) Queens  

Technology Transfer Automated Retrieval System (TEKTRAN)

The oviposition process of Solenopsis invicta is described as a succession of four events forming one egg-laying cycle. Each time an egg is laid, the vulva opens and the sting is fully extended. When the vulva closes, the egg is forced to the base of the sting, whereupon the sting is usually retract...

150

Molecular characterization of a Spirometra mansoni antigenic polypeptide gene encoding a 28.7 kDa protein.  

PubMed

The Spirometra mansoni antigenic polypeptide (SmAP) gene was expressed in Escherichia coli, and its characteristics and value as an antigen for the serodiagnosis of sparganosis were investigated. The recombinant SmAP protein (rSmAP) has the molecular weight of 28.7 kDa. On Western blotting analysis, the rSmAP strongly reacted with the sera of mice infected with spargana, but not with normal sera; the anti-rSmAP serum obviously recognized the 28.7-kDa band in the crude antigens and excretory-secretory (ES) antigens of spargana. The immunofluorescence test (IFT) results showed that the positive staining was observed at different stages of spargana from the infected frogs and mice, but not adult worm of S. mansoni. An immunolocalization analysis identified SmAP in the teguments and parenchymal tissues of spargana. ELISA with rSmAP antigen or sparganum ES antigens were evaluated for the serodiagnosis of sparganosis. The results showed that the sensitivity of rSmAP-ELISA and ES-ELISA was 83.3% (25/30) and 100% (30/30), respectively, for the detection of anti-sparganum IgG antibodies in sera of the experimentally infected mice (P?>?0.05), the specificities of both ELISA were 100% (67/67). It is suggested that the rSmAP might be a potential candidate antigen for serodiagnosis of sparganosis. PMID:25096536

Cui, Jing; Wei, Tong; Liu, Li Na; Zhang, Xi; Qi, Xin; Zhang, Zi Fang; Wang, Zhong Quan

2014-09-01

151

An Unusual Gross Appearance of Vulval Tuberculosis Masquerading as Tumor  

PubMed Central

Tuberculosis of the vulva is very rare. It is found in about 0.2% of the cases of genital tract tuberculosis. It usually presents as small shallow ulcers and multiple sinus tracts or rarely as elephantiasis of vulva. Except for very rare cases of primary tuberculosis in the vulva, it is usually associated with tuberculosis elsewhere in the body leading to secondary tuberculosis. Here, we report a case of secondary vulval tuberculosis which presented as a vulval mass in a 40-year-old female patient. The rarity of this presentation in the female genital tract is emphasized. PMID:25298898

Arakeri, Surekha U.

2014-01-01

152

Morphology and physiological changes of genital skin and mucosa.  

PubMed

The morphology and physiology of both the vulva and vagina undergo characteristic age-related changes over a lifetime. At birth, these tissues exhibit the effects of residual maternal estrogens. During puberty, the vulva and vagina mature under the influence of adrenal and gonadal steroid hormones. During the reproductive years, the vagina responds to ovarian steroid hormone cycling, and both tissues adapt to the needs of pregnancy and delivery. Following menopause, the vulva and vagina atrophy. A rise in the prevalence of incontinence among older women increases the risk of vulvar and perineal dermatitis. This chapter covers the morphology and physiology of the genital area from infancy to old age. PMID:21325836

Farage, Miranda A; Maibach, Howard I

2011-01-01

153

An unusual gross appearance of vulval tuberculosis masquerading as tumor.  

PubMed

Tuberculosis of the vulva is very rare. It is found in about 0.2% of the cases of genital tract tuberculosis. It usually presents as small shallow ulcers and multiple sinus tracts or rarely as elephantiasis of vulva. Except for very rare cases of primary tuberculosis in the vulva, it is usually associated with tuberculosis elsewhere in the body leading to secondary tuberculosis. Here, we report a case of secondary vulval tuberculosis which presented as a vulval mass in a 40-year-old female patient. The rarity of this presentation in the female genital tract is emphasized. PMID:25298898

Arakeri, Surekha U; Sinkar, Prachi

2014-01-01

154

The Caenorhabditis elegans AMP-activated Protein Kinase AAK-2 Is Phosphorylated by LKB1 and Is Required for  

E-print Network

prolif- eration is reminiscent of the observation that AMPK induces G1 arrest by phosphorylating p53 protein fusion protein was observed in the ventral cord, some neurons, body wall muscle, pharynx, vulva

Gartner, Anton

155

Vulvodynia  

MedlinePLUS

... vulvodynia diagnosed? • What is involved in the physical exam? • What is the first step I can take ... skin problems. What is involved in the physical exam? Your health care provider will examine the vulva ...

156

What's New in Vulvar Cancer Research and Treatment?  

MedlinePLUS

... the vulva. There are some promising new developments. Oncogenes and tumor suppressor genes Scientists are learning more about how certain genes called oncogenes and tumor suppressor genes control cell growth and ...

157

Gonorrhea, Chlamydia, and Syphilis  

MedlinePLUS

... of the feet and palms of the hands. Flat warts may be seen on the vulva. During ... of the uterus, fallopian tubes, and nearby pelvic structures. Sexually Transmitted Diseases (STDs): Diseases that are spread ...

158

20 CFR 10.404 - When and how is compensation for a schedule impairment paid?  

Code of Federal Regulations, 2011 CFR

...one) 156 Larynx 160 Lung (one) 156 Penis 205 Testicle (one) 52 Tongue 160 Ovary (one) 52 Uterus/cervix and vulva/vagina 205 (b) Compensation for schedule awards is payable at 662/3 percent of the...

2011-04-01

159

20 CFR 10.404 - When and how is compensation for a schedule impairment paid?  

Code of Federal Regulations, 2014 CFR

...one) 156 Larynx 160 Lung (one) 156 Penis 205 Testicle (one) 52 Tongue 160 Ovary (one) 52 Uterus/cervix and vulva/vagina 205 Skin 205 (c) Compensation for schedule awards is payable at 662/3 percent...

2014-04-01

160

20 CFR 10.404 - When and how is compensation for a schedule impairment paid?  

Code of Federal Regulations, 2012 CFR

...one) 156 Larynx 160 Lung (one) 156 Penis 205 Testicle (one) 52 Tongue 160 Ovary (one) 52 Uterus/cervix and vulva/vagina 205 Skin 205 (c) Compensation for schedule awards is payable at 662/3 percent...

2012-04-01

161

20 CFR 10.404 - When and how is compensation for a schedule impairment paid?  

Code of Federal Regulations, 2013 CFR

...one) 156 Larynx 160 Lung (one) 156 Penis 205 Testicle (one) 52 Tongue 160 Ovary (one) 52 Uterus/cervix and vulva/vagina 205 Skin 205 (c) Compensation for schedule awards is payable at 662/3 percent...

2013-04-01

162

Bilateral, perivulval cuticular pores in trichostrongylid nematodes.  

PubMed

A new hypodermal gland was discovered in female nematodes of the family Trichostrongylidae. Because the new structure appears to be associated with the vulva, it was named the perivulval pore. It is similar, based on light and scanning electron microscopy, to phasmids that are located laterally on the tails of nematodes of the class Secernentea. Like phasmids, perivulval pores are paired and bilateral, with cuticular ducts to the surface in the areas of the lateral chords. They are located slightly posterior to the vulva in Haemonchus contortus, Haemonchus placei, Haemonchus similis, Mecistocirrus digitatus, Mazamastrongylus pursglovei, Ostertagia ostertagi, and Cooperia oncophora, but in Trichostrongylus colubriformis they are slightly anterior to the vulva. Because of the location near the vulva and the similarity in structure to phasmids, which are, at least in part, secretory, the perivulval pores should be considered as a possible source of a female attractant for males. PMID:7623208

Lichtenfels, J R; Wergin, W P; Murphy, C; Pilitt, P A

1995-08-01

163

28 CFR 115.6 - Definitions related to sexual abuse.  

Code of Federal Regulations, 2014 CFR

...and the penis, vulva, or anus; (3) Penetration of the anal or genital opening of another person, however slight, by a...arouse, or gratify sexual desire; (4) Penetration of the anal or genital opening, however slight, by a hand,...

2014-07-01

164

28 CFR 115.6 - Definitions related to sexual abuse.  

Code of Federal Regulations, 2012 CFR

...and the penis, vulva, or anus; (3) Penetration of the anal or genital opening of another person, however slight, by a...arouse, or gratify sexual desire; (4) Penetration of the anal or genital opening, however slight, by a hand,...

2012-07-01

165

28 CFR 115.6 - Definitions related to sexual abuse.  

Code of Federal Regulations, 2013 CFR

...and the penis, vulva, or anus; (3) Penetration of the anal or genital opening of another person, however slight, by a...arouse, or gratify sexual desire; (4) Penetration of the anal or genital opening, however slight, by a hand,...

2013-07-01

166

What Is Vulvar Cancer?  

MedlinePLUS

... Bartholin glands less often. Types of vulvar cancer Squamous cell carcinomas Most cancers of the vulva are squamous cell ... of skin cells. There are several subtypes of squamous cell carcinoma: The keratinizing type is most common, and usually ...

167

Vaginal Discharge  

MedlinePLUS

... on the lookout for symptoms of yeast infections, bacterial vaginosis and trichomoniasis, 3 infections that can cause changes ... vulva Intense itching Painful sexual intercourse Signs of bacterial vaginosis A white, gray or yellowish vaginal discharge A ...

168

Vaginitis  

MedlinePLUS

... itching, burning, and pain on the vulva. What causes it? » Last Updated Date: 11/15/2013 Last Reviewed Date: 05/21/2013 Related A-Z Topics Bacterial Vaginosis Contraception and Birth Control Sexually Transmitted Diseases (STDs) ...

169

Clinical, genetic, and pathological features of male pseudohermaphroditism in dog  

PubMed Central

Male pseudohermaphroditism is a sex differentiation disorder in which the gonads are testes and the genital ducts are incompletely masculinized. An 8 years old dog with normal male karyotype was referred for examination of external genitalia abnormalities. Adjacent to the vulva subcutaneous undescended testes were observed. The histology of the gonads revealed a Leydig and Sertoli cell neoplasia. The contemporaneous presence of testicular tissue, vulva, male karyotype were compatible with a male pseudohermaphrodite (MPH) condition. PMID:21255434

2011-01-01

170

Neuroparasitic Infections: Cestodes, Trematodes, and Protozoans  

PubMed Central

Parasitic infection of the nervous system can produce a variety of symptoms and signs. Because symptoms of infection are often mild or nonspecific, diagnosis can be difficult. Familiarity with basic epidemiological characteristics and distinguishing radiographic findings can increase the likelihood of detection and proper treatment of parasitic infection of the nervous system. This article discusses the clinical presentation, diagnosis, and treatment for some of the more common infections of the nervous system caused by cestodes, trematodes and protozoans: Echinococcus spp., Spirometra spp. (sparganosis), Paragonimus spp., Schistosoma spp., Trypanosoma spp., Naegleria fowlerii, Acanthamoeba histolytica, and Balamuthia mandrillaris. PMID:16170739

Walker, M.D.; Zunt, J.R.

2009-01-01

171

Pentastomiasis and other parasitic zoonoses from reptiles and amphibians.  

PubMed

Reptiles are growing in popularity as pets.The colonization of reptiles and amphibians by parasites and the resulting disease conditions are the most common problems seen in captive animals.This review focuses on pentastomiasis and sparganosis, important parasitic zoonoses of reptiles and amphibians, respectively, and free living-amoebae. Humans are suitable accidental hosts for some pentastomid species (particularly Armillifer and Porocephalus). In geographical areas with special ethnics, such as in West and Central Africa, and East Asia, 8-45% of the human population can be affected. Usually the larvae are coincidentally found during abdominal surgeries. However, fatalities have been described. Extreme caution is necessary when handling infected reptiles. Ocular or cerebral sparganosis is not uncommonly found in humans in East Asia. This disease is caused by spargana, tapeworm larvae (plerocercoids) of Spirometra sp. The infection occurs when uncooked meat from reptiles or amphibians is applied to wounds or eyes and the parasites migrate directly to human tissue, or by consumption of contaminated food or water. As a consequence of the reptile's predatory behaviour, the full spectrum of endo- and ectoparasites from potential prey animals can be found as transiting parasites in the intestinal tract, e. g. Hymenolepis nana, Cryptosporidium (C.) muris, C parvum or Capillaria hepatica. Occasionally, free-living amoebae are also found in reptile faeces (Acanthamoeba, Naegleria, Hartmanella, Vahlkampfia or Echinamoeba sp.). PMID:22191176

Pantchev, Nikola; Tappe, Dennis

2011-01-01

172

Spirometra (Pseudophyllidea, Diphyllobothriidae) severely infecting wild-caught snakes from food markets in Guangzhou and Shenzhen, Guangdong, China: implications for public health.  

PubMed

Sparganosis is a zoonotic disease caused by the spargana of Spirometra, and snake is one of the important intermediate hosts of spargana. In some areas of China, snake is regarded as popular delicious food, and such a food habit potentially increases the prevalence of human sparganosis. To understand the prevalence of Spirometra in snakes in food markets, we conducted a study in two representative cities (Guangzhou and Shenzhen), during January-August 2013. A total of 456 snakes of 13 species were examined and 251 individuals of 10 species were infected by Spirometra, accounting for 55.0% of the total samples. The worm burden per infected snake ranged from 1 to 213, and the prevalence in the 13 species was 0?96.2%. More than half (58.1%) of the spargana were located in muscular tissue, 25.6% in subcutaneous tissue, and 16.3% in coelomic cavity. The results indicated that Spirometra severely infected snakes in food markets in Guangzhou and Shenzhen, implying that eating snakes has great health risk and improper cooking methods may increase the risk of Spirometra infection in humans in China. Additional steps should be considered by the governments and public health agencies to prevent the risk of snake-associated Spirometra infections in humans. PMID:24558340

Wang, Fumin; Li, Weiye; Hua, Liushuai; Gong, Shiping; Xiao, Jiajie; Hou, Fanghui; Ge, Yan; Yang, Guangda

2014-01-01

173

Spirometra (Pseudophyllidea, Diphyllobothriidae) Severely Infecting Wild-Caught Snakes from Food Markets in Guangzhou and Shenzhen, Guangdong, China: Implications for Public Health  

PubMed Central

Sparganosis is a zoonotic disease caused by the spargana of Spirometra, and snake is one of the important intermediate hosts of spargana. In some areas of China, snake is regarded as popular delicious food, and such a food habit potentially increases the prevalence of human sparganosis. To understand the prevalence of Spirometra in snakes in food markets, we conducted a study in two representative cities (Guangzhou and Shenzhen), during January–August 2013. A total of 456 snakes of 13 species were examined and 251 individuals of 10 species were infected by Spirometra, accounting for 55.0% of the total samples. The worm burden per infected snake ranged from 1 to 213, and the prevalence in the 13 species was 0?96.2%. More than half (58.1%) of the spargana were located in muscular tissue, 25.6% in subcutaneous tissue, and 16.3% in coelomic cavity. The results indicated that Spirometra severely infected snakes in food markets in Guangzhou and Shenzhen, implying that eating snakes has great health risk and improper cooking methods may increase the risk of Spirometra infection in humans in China. Additional steps should be considered by the governments and public health agencies to prevent the risk of snake-associated Spirometra infections in humans. PMID:24558340

Gong, Shiping

2014-01-01

174

Infectious Anaemia of the Horse: A Preliminary Report.  

E-print Network

-coated bowel discharges from the anus, (3) coffee-colored urine dribbling from the vulva. The mucous membranes of the mouth, anus and vulva are very pale or yellowish. Those of the eye and nose show petechiae. The pleurae, peritoneum and pericardium show... petechiae and fibrin- ous exudates. The heart muscle on the left side is hemorrhagic. The liver is enlarged, weighing 20 pounds, and very dark in color. Kidneys contain a greyish, pus-like substance, the right one weighs 1270 grams, the left 1130 grams...

Francis, M. (Mark); Marsteller, R. P. (Ross Perry)

1908-01-01

175

Quit Obsessing!  

ERIC Educational Resources Information Center

Asserts the obsessive-compulsive disorder is often misdiagnosed in children and adolescents; describes characteristics of obsessive-compulsive disorder; differentiates between normal and abnormal obsessions; suggests ways teachers can help students diagnosed with the disorder. (PKP)

Schlozman, Steven C.

2002-01-01

176

75 FR 69086 - Agency Forms Undergoing Paperwork Reduction Act Review  

Federal Register 2010, 2011, 2012, 2013, 2014

...history of individuals diagnosed with the disease); and (4) better examine the connection between ALS and other motor neuron disorders that can be confused with ALS, misdiagnosed as ALS, and in some cases progress to ALS. The registry...

2010-11-10

177

75 FR 28621 - Proposed Data Collections Submitted for Public Comment and Recommendations  

Federal Register 2010, 2011, 2012, 2013, 2014

...gender, and family history) associated with the disease; and (4) better examine the connection between ALS and other motor neuron disorders that can be confused with ALS, misdiagnosed as ALS, and in some cases progress to ALS. The registry...

2010-05-21

178

Sinus Headache or Migraine  

MedlinePLUS

... Points: Migraine is commonly misdiagnosed as sinus headache. Self-diagnosed sinus headache is nearly always migraine (~90% of ... symptoms. A very large study involving almost 3000 patients was very important in evaluating the frequent complaint ...

179

Noname manuscript No. (will be inserted by the editor)  

E-print Network

to a taxonomic problem involving species of suckers in the genus Carpiodes. The results confirm the necessity have traditionally been misdiagnosed as C. carpio but are in fact more close to C. cyprinus. We also

Chen, Yixin

180

CADASIL  

MedlinePLUS

... arteries. CADASIL is characterized by migraine headaches and multiple strokes progressing to dementia. Other symptoms include cognitive ... available before 2000, many cases were misdiagnosed as multiple sclerosis, Alzheimer's disease, or other neurodegenerative diseases. Is ...

181

Monogenic Diabetes  

MedlinePLUS

... gene. In contrast, the most common types of diabetes—type 1 and type 2—are caused by multiple genes ( ... some children with monogenic diabetes are misdiagnosed with type 1 diabetes and are given insulin. When correctly diagnosed, some ...

182

The emergence of mecC methicillin-resistant Staphylococcus aureus  

E-print Network

The report of methicillin-resistant Staphylococcus aureus (MRSA) encoding a divergent mecA gene in 2011 was highly significant. This homologue, designated mecC, poses diagnostic problems with the potential to be misdiagnosed as methicillin...

Paterson, Gavin K.; Harrison, Ewan M.; Holmes, Mark A.

2013-11-12

183

Prospective Study of Antibody to Human Papilloma Virus type 16 and Risk of Cervical, Endometrial, and Ovarian Cancers (United States)  

Microsoft Academic Search

Objective: Human papilloma virus (HPV) is frequently detectable in cancers of the cervix, vagina, and vulva, but its role in endometrial and ovarian cancers is less certain. This analysis aimed to examine the association of presence of HPV type 16 (HPV-16) antibodies with subsequent risk of cervical, endometrial, and ovarian cancers. Methods: In a prospective study enrolling over 15,000 pregnant

Michie Hisada; Beavanden J. Berg; Howard D. Strickler; Roberta E. Christianson; William E. Wright; David J. Waters; Charles S. Rabkin

2001-01-01

184

The Nematode Pristionchus pacificus (Nematoda: Diplogastridae) Is Associated with the Oriental Beetle Exomala orientalis (Coleoptera: Scarabaeidae) in Japan  

Microsoft Academic Search

Pristionchus pacificus has been developed as a nematode satellite organism in evolutionary devel- opmental biology. Detailed studies of vulva development revealed multiple differences in genetic and molecular control in P. pacificus compared to the model organism Caenorhabditis elegans. To place evolutionary developmental biology in a comprehensive evolutionary context, such studies have to be complemented with ecology. In recent field studies

Matthias Herrmann; Werner E. Mayer; Ray L. Hong; Simone Kienle; Ryuji Minasaki; Ralf J. Sommer

2007-01-01

185

Chapter 1: HPV in the etiology of human cancer  

Microsoft Academic Search

The causal role of human papillomavirus (HPV) in all cancers of the uterine cervix has been firmly established biologically and epidemiologically. Most cancers of the vagina and anus are likewise caused by HPV, as are a fraction of cancers of the vulva, penis, and oropharynx. HPV-16 and -18 account for about 70% of cancers of the cervix, vagina, and anus

Nubia Muńoz; Xavier Castellsagué; Amy Berrington de González; Lutz Gissmann

2006-01-01

186

Expression of the CDK inhibitor p27kip1 and oxidative DNA damage in non-neoplastic and neoplastic vulvar epithelial lesions  

Microsoft Academic Search

Vulvar cancer represents an important medical problem worldwide whose incidence is increasing at an alarming rate in young females. Several factors have been linked to vulvar cancer development, but its exact pathogenesis remains to be determined. Vulvar tumorigenesis proceeds through intermediate dysplastic lesions, known as vulvar intraepithelial neoplasias, frequently associated with non-neoplastic epithelial disorders of the vulva, such as lichen

Gian F Zannoni; Beatrice Faraglia; Elisabetta Tarquini; Andrea Camerini; Karen Vrijens; Mario Migaldi; Achille Cittadini; Alessandro Sgambato

2006-01-01

187

Aggressive Angiomyxoma of the Pelviperineum: Surgical Treatment through a Perineal Incision  

Microsoft Academic Search

Aggressive angiomyxoma is a rare benign tumor of the pelvic soft tissue in women of reproductive age. The tumor is locally infiltrative and tends to recur. Herein is presented a case report of aggressive angiomyxoma that was totally excised using a transperineal approach. A 35-year-old woman had an aggressive angiomyxoma of the vulva and pelvis, with swelling of the right

Ahmet Cem Iyibozkurt; Cenk Yasa; Doerte Elisabeth Schmieta; Funda Gungor-Ugurlucan; Samet Topuz; Sinan Berkman

2011-01-01

188

Morphological and molecular characterization of Pratylenchus lentis n. sp. (Nematoda: Pratylenchidae) from Sicily  

Technology Transfer Automated Retrieval System (TEKTRAN)

Pratylenchus lentis n. sp. parasitizing roots of lentil in Sicily, Italy, is described and illustrated. The new species is characterized by a high lip region with three annuli, stylet mean length of 16 micrometers with anteriorly flattened knobs, cylindrical body with a relatively anterior vulva, l...

189

INTRODUCTION A central issue in developmental biology is how discrete cells  

E-print Network

; discussed in Li and Chalfie, 1990; Thomas et al., 1990). Eggs are stored in the mesodermal uterus, once formed, the vulva connects properly to the uterus. A signal from the uterine anchor cell (AC that attach the uterus to the lateral epidermis (seam) on each side of the animal, connected by a thin planar

Horvitz, H. Robert

190

Purdue extensionPurdue extension AS-561-WAS-561-W  

E-print Network

is the cervix. The cervix is the barrier between the vagina and the uterus. It serves to protect the more delicate and highly vascularized uterus from invasion by foreign uterine horns uterus cervix vagina vulva · Knowledge to Go objects, and is also a tight seal that keeps the uterus closed during pregnancy. The uterus

191

Herpes Simplex and Herpes Genitalis Viruses in Etiology of Some Human Cancers  

Microsoft Academic Search

The results of complement fixation tests on 202 sera from people without cancer and from patients with cancer in 29 different areas of the body indicated that only those with nine varieties of advanced cancer (lip, mouth, oropharynx, nasopharynx, kidney, urinary bladder, prostate, cervix uteri, and vulva-all of 56 tested) gave positive specific reactions with nonvirion antigens induced by the

Albert B. Sabin; Giulio Tarro

1973-01-01

192

Familial partial lipodystrophy: two types of an X linked dominant syndrome, lethal in the hemizygous state  

Microsoft Academic Search

Familial lipodystrophy (referred to in publications as the Köbberling-Dunnigan syndrome) comprises at least two clinical phenotypes which are consistent within each pedigree. In type 1 familial lipodystrophy, loss of subcutaneous fat is confined to the limbs, sparing the face and trunk. In type 2 familial lipodystrophy, the trunk is also affected with the exception of the vulva, giving an appearance

J Köbberling; M G Dunnigan

1986-01-01

193

Morphogenesis, the development of shape and form, has been described as the `next frontier' of develop-  

E-print Network

Morphogenesis, the development of shape and form, has been described as the `next frontier progress in understanding one aspect of C. elegans epithelial morphogenesis: the embryonic development. The morphogenesis of other epithelial organs, such as the gut2 , gonads3 , hermaphrodite vulva4 , and male tail5

Chisholm, Andrew

194

Preliminary experiences with sentinel lymph node detection in cases of vulvar malignancy  

Microsoft Academic Search

Lymph node status is the most important prognostic factor in vulvar malignancy. The aim of this pilot study was to explore the clinical significance of radionuclide lymphoscintigraphy in the management of vulvar neoplasms. Eight patients with squamous cell carcinoma and two patients with malignant melanoma of the vulva were studied with 100 MBq technetium-99m nanocolloid (Sentiscint, OSSKI, Budapest) 1 day

Katalin Zámbó; Erzsébet Schmidt; Tamás Hartmann; László Kornya; Babak Dehghani; Hans Rudolf Tinneberg; József Bódis

2002-01-01

195

Lichen sclerosus  

Microsoft Academic Search

Lichen sclerosus, usually appearing in the dermatologic literature under the names of lichen sclerosus et atrophicus, balanitis xerotica obliterans, and kraurosis vulvae, is an inflammatory disease with a multifactorial origin. A past association of lichen sclerosus and genital squamous cell carcinoma is not as close as once thought. Once considered primarily a surgical problem, especially when the genitals were involved,

Jeffrey J Meffert; Brian M Davis; Ronald E Grimwood

1995-01-01

196

Vaginal itching and discharge - Adult and adolescent  

MedlinePLUS

... or thin Clear, cloudy, bloody, white, yellow, or green Odorless or have a bad odor Itching of the skin of the vagina and the surrounding area (vulva) may be present along with vaginal discharge. It can also occur on its own.

197

Assessment of calving progress and reference times for obstetric intervention during dystocia in Holstein dairy cows  

Microsoft Academic Search

The objectives of this observational study were (1) to assess the time from the appearance of the amniotic sac (AS) or feet outside the vulva to birth in Holstein cows (primiparous and multiparous) with (dystocia) or without assistance (eutocia) at calving, and (2) to estimate reference times to be used as guidelines for obstetric intervention in Holstein cows that need

G. M. Schuenemann; I. Nieto; S. Bas; K. N. Galvăo; J. Workman

2011-01-01

198

HUMAN GENE THERAPY 17:147157 (February 2006) Mary Ann Liebert, Inc.  

E-print Network

of malignant disease including cancer of the vulva, oral cancer, and skin cancer. In HPV-transformed cells Kills Bystander Cells and Offers a Route for Cervical Cancer Gene Therapy KATIE L. GREEN,1 TOM D papillomaviruses (HPVs) are a causative agent of cervical cancer and are implicated in several other types

Gaston, Kevin

199

HUMAN GENE THERAPY 18:547561 (June 2007) Mary Ann Liebert, Inc.  

E-print Network

. #12;diseases including cancer of the vulva, oral cancer, and skin cancer (Beckmann et al., 1988.042 A Cancer Cell-Specific Inducer of Apoptosis KATIE L. GREEN,1 CRAIG BROWN,1 GERALDINE E. ROEDER,1 THOMAS D cancers, strongly suggesting that these viruses are necessary to initiate this disease. The HPV E2 protein

Gaston, Kevin

200

GENITAL HUMAN PAPILLOMA VIRUS (HPV) Dartmouth COOP  

E-print Network

identified; 30 of them affect the genital tract. 3. All types of HPV are spread by SKIN TO SKIN contact. Risk factors for HPV including previous treatment for cancer or precancer, HIV infection, weakened. HPV is the only cause of cervical cancer. HPV may also be linked to cancer of the anus, vulva, vagina

201

Evaluation of the Role of Vibrational Spectroscopy in the Assessment of Vulval Disease  

ClinicalTrials.gov

Normal Vulval Skin; Lichen Sclerosus; High Grade Dysplasia - Usual Type ('VIN 2-3'); High Grade Dysplasia - Differentiated Type ('VIN 2-3'); Squamous Cell Carcinoma; Epithelial Hyperplasia Without Atypia; Atypia Not Otherwise Specified/ Low Grade Dysplasia ('VIN 1'); Pagets Disease of the Vulva

2014-08-21

202

Urogenital tumors  

SciTech Connect

An overview is provided for veterinary care of urogenital tumors in companion animals, especially the dog. Neoplasms discussed include tumors of the kidney, urinary bladder, prostate, testis, ovary, vagina, vulva and the canine transmissible venereal tumor. Topics addressed include description, diagnosis and treatment.

Weller, R.E.

1994-03-01

203

Genetic Control of Vulval Development in Caenorhabditis briggsae  

PubMed Central

The nematode Caenorhabditis briggsae is an excellent model organism for the comparative analysis of gene function and developmental mechanisms. To study the evolutionary conservation and divergence of genetic pathways mediating vulva formation, we screened for mutations in C. briggsae that cause the egg-laying defective (Egl) phenotype. Here, we report the characterization of 13 genes, including three that are orthologs of Caenorhabditis elegans unc-84 (SUN domain), lin-39 (Dfd/Scr-related homeobox), and lin-11 (LIM homeobox). Based on the morphology and cell fate changes, the mutants were placed into four different categories. Class 1 animals have normal-looking vulva and vulva-uterine connections, indicating defects in other components of the egg-laying system. Class 2 animals frequently lack some or all of the vulval precursor cells (VPCs) due to defects in the migration of P-cell nuclei into the ventral hypodermal region. Class 3 animals show inappropriate fusion of VPCs to the hypodermal syncytium, leading to a reduced number of vulval progeny. Finally, class 4 animals exhibit abnormal vulval invagination and morphology. Interestingly, we did not find mutations that affect VPC induction and fates. Our work is the first study involving the characterization of genes in C. briggsae vulva formation, and it offers a basis for future investigations of these genes in C. elegans. PMID:23275885

Sharanya, Devika; Thillainathan, Bavithra; Marri, Sujatha; Bojanala, Nagagireesh; Taylor, Jon; Flibotte, Stephane; Moerman, Donald G.; Waterston, Robert H.; Gupta, Bhagwati P.

2012-01-01

204

On the description of two new species of Paurodontella (Nematoda: Paurodontinae) with a key and diagnostic compendium to the species of the genus  

Technology Transfer Automated Retrieval System (TEKTRAN)

Two new species of Paurodontella collected around the roots of wheat (Triticum aestivum L.) are described and illustrated. One new species is characterized by having a short cylindrical, robust body markedly tapering at both ends with an anteriorly located vulva, short post-uterine sac, lateral fiel...

205

Characterization of a New Species of Cyst Nematode Parasitizing Corn  

Technology Transfer Automated Retrieval System (TEKTRAN)

Examination of soil around unthrifty corn roots in northwestern Tennessee (Obion County) in 2006 revealed high population densities of juvenile nematodes and lemon-shaped cysts. This nematode resembles Cactodera spp. in possessing a circumfenestrate vulva but lacking bullae and an underbridge. These...

206

RESMDD'02 Radiation in Life Sciences: Hartmut F.-W. Sadrozinski , SCIPP Radiation Effects in  

E-print Network

RESMDD'02 Radiation in Life Sciences: Hartmut F.-W. Sadrozinski , SCIPP SCIPPSCIPP Radiation Effects in Life Sciences oocyte eggs in uterus spermatheca gonad vulva Quality of Radiation Biological Radiation in Life Sciences: Hartmut F.-W. Sadrozinski , SCIPP SCIPPSCIPP Radiation in Life Sciences Why

California at Santa Cruz, University of

207

Laser versus Loop Electrosurgical Excision in Vulvar Condyloma for Eradication of Subclinical Reservoir Demonstrated by Assay for 2’-5’Oligosynthetase Human Papillomavirus  

Microsoft Academic Search

We studied, in an open clinical trial, 28 women with giant solitary human papillomavirus (HPV) lesions of the vulva that were treated by both laser and the loop electrosurgical excision procedure (LEEP), and analyzed the biopsy specimens of normal skin adjacent to the lesions for papillomavirus sequencs by Southern blot hybridization and 2’-5’ oligo-A synthetase (interferon) activity. The patients were

A. Schoenfeld; E. Ziv; H. Levavi; Z. Samra; J. Ovadia

1995-01-01

208

Eosinophilic Pleuritis due to Sparganum: A Case Report  

PubMed Central

Sparganosis is a rare parasitic disease caused by migrating plerocercoid tapeworm larva of the genus Spirometra. Infection in humans is mainly caused by the ingestion of raw or inadequately cooked flesh of infected frogs, snakes, and chickens. Here, we report a rare case of a 45-year-old man who was admitted to our hospital with left lower chest pain. The chest radiograph and computed tomography (CT) scan revealed localized pleural effusion in the left lower lobe; further, peripheral blood eosinophilia and eosinophilic pleural effusion were present. Percutaneous catheter drainage was performed, which revealed long worm-shaped material that was identified as a sparganum by DNA sequencing. The patient showed clinical improvement after drainage of the sparganum. This study demonstrates the importance of considering parasitic diseases in the differential diagnosis of eosinophilic pleural effusion. PMID:25352705

Oh, Youngmin; Kim, Jeong-Tae; Kim, Mi-Kyeong; Chang, You-Jin; Eom, Keeseon; Park, Jung-Gi; Lee, Ki-Man; Choe, Kang-Hyeon

2014-01-01

209

An Imported Case of Echinococcosis of the Liver in a Korean Who Traveled to Western and Central Europe  

PubMed Central

Echinococcus granulosus, an intestinal tapeworm of dogs and other canids, infects humans in its larval stage and causes human echinococcosis or hydatid disease. In the Republic of Korea, 31 parasite-proven human echinococcosis cases have been reported, most of which were imported from the Middle East. We recently examined a 61-year-old Korean man who had a large cystic mass in his liver. ELISA was negative for tissue parasitic infections, including echinococcosis, cysticercosis, paragonimiasis, and sparganosis. The patient underwent surgery to remove the cyst, and the resected cyst was processed histopathologically for microscopic examinations. In sectioned cyst tissue, necrotizing protoscolices with disintegrated hooklets of E. granulosus were found. In some areas, only freed, fragmented hooklets were detected. The patient had traveled to western and central Europe in 1996, and had no other history of overseas travel. We report our patient as a hepatic echinococcosis case which was probably imported from Europe. PMID:20585534

Byun, Sun-Ju; Moon, Kyung Chul; Suh, Kyung-Suk; Han, Joon Koo

2010-01-01

210

Long term diarrhoea caused by simultaneous Crohn’s disease and coeliac disease in the same patient  

PubMed Central

Coeliac disease and Crohn’s disease are among the most well known gastrointestinal disorders, with distinct pathogenic mechanisms. However, because of some overlapping features between these two conditions, there may be some inevitable misdiagnoses. In addition, diarrhoea and changes in bowel habit may lead the physician to misdiagnose more common disorders such as irritable bowel syndrome. There are a few cases reporting both coeliac and Crohn’s disease in the same patient. Here we report a case of a 32-year-old woman suffering from long term diarrhoea who was eventually discovered to have coeliac disease and Crohn’s disease simultaneously. PMID:22427783

Asadi, Mehrnaz; Malekzadeh, Fateme; Roshan, Nader

2010-01-01

211

Perioral dermatitis -- the role of nasal steroids.  

PubMed

We present two patients with allergic rhinitis who developed perioral dermatitis (PD) after initiating intranasal steroid spray. Both patients had been previously misdiagnosed as having contact or seborrheic dermatitis, and therefore inappropriately and unsuccessfully treated with topical steroids. Physicians should be aware of this potential side effect of intranasal steroids to avoid incorrect therapeutic measures. In the setting of nasal steroids use, PD probably is an under-reported and commonly misdiagnosed condition that should be thought when a patient treated with nasal steroids present with small erythematous papules, papulovesicles, and papulopustules occurring against a background of redness, beginning in the nasolabial areas and spreading rapidly to the perioral zone. PMID:21995785

Peralta, Lígia; Morais, Paulo

2012-06-01

212

Chondroid melanoma metastatic to lung and skin showing SOX-9 expression: a potential diagnostic pitfall.  

PubMed

Melanoma is a malignant neoplasm that shows multiple morphological appearances resembling other tumors and therefore may generate diagnostic pitfalls. In cases of metastatic melanoma, when the primary skin lesion has gone undiscovered or has not been brought to the attention of the clinician or pathologist, the metastatic lesion can be misdiagnosed as sarcoma, carcinoma, or lymphoma. Melanomas with differentiation toward mesenchymal elements are particularly perilous in this regard. Here, the authors report a case of metastatic melanoma that was misdiagnosed as extraskeletal myxoid chondrosarcoma. This case highlights the potential diagnostic pitfall posed by metastatic melanoma with chondroid matrix and SOX-9 expression. PMID:22334614

McKay, Kristopher M; Deavers, Michael T; Prieto, Victor G

2012-04-01

213

Morphological Variation in Xiphinema spp. from New York Orchards  

PubMed Central

Xiphinema specimens were collected from orchards in southeastern, northeastern, and western New York. Total length, distance of vulva from anterior end, spear length (odontostyle plus odontophore), body diameter at vulva, tail length, anal body diameter, and length and diameter of hyaline tail tip were measured on fixed, glycerol-infiltrated adult females. Most specimens were identified as X. americanum or X. rivesi, but one western New York population was identified as X. californicum (a new record for New York). Multivariate analyses indicated that, with one exception, western New York populations of both X. americanum and X. rivesi were smaller and slimmer than their eastern counterparts. Regional differences were generally larger than differences attributed to host species. PMID:19290184

Georgi, Laura L.

1988-01-01

214

Magnetic resonance imaging of vulvar dermatofibrosarcoma protuberans – report of a case  

PubMed Central

Background Dermatofibrosarcoma protuberans (DFSP) of the vulva is a rare low-grade soft tissue sarcoma. Magnetic resonance imaging (MRI) findings of vulvar DFSP were essentially unreported in the literature. Case report We report a DFSP of vulva with its clinical, histological and MRI features. As far we know this is the first case of histologically confirmed vulvar DFSP presenting with MR images. The diagnosis of DFSP is usually made by histopathologic and clinical findings. Conclusions MRI is useful both for the diagnosis of DFSP and following up the patients since it has high soft tissue resolution and no risk of radiation exposure. With MRI the relation to the adjacent anatomical structures, extension and depth of the tumour and possible lymph node involvement can also be demonstrated. PMID:24133389

Ozmen, Evrim; Güney, Güven; Algin, Oktay

2013-01-01

215

Urogenital atrophy.  

PubMed

The major cause of urogenital atrophy in menopausal women is estrogen loss. The symptoms are usually progressive in nature and deteriorate with time from the menopausal transition. The most prevalent urogenital symptoms are vaginal dryness, vaginal irritation and itching. The classical changes in an atrophic vulva include loss of labial and vulvar fullness, with narrowing of the introitus and inflamed mucosal surfaces. Dyspareunia and vaginal bleeding from fragile atrophic skin are common problems. Other urogenital complaints include frequency, nocturia, urgency, incontinence and urinary tract infections. Atrophic changes of the vulva, vagina and lower urinary tract can have a large impact on the quality of life of the menopausal woman. However, hormonal and non-hormonal treatments can provide patients with the solution to regain previous level of function. Therefore, clinicians should sensitively question and examine menopausal women, in order to correctly identify the pattern of changes in urogenital atrophy and manage them appropriately. PMID:19387880

Calleja-Agius, J; Brincat, M P

2009-08-01

216

[Vulvar pathology].  

PubMed

We evaluated the main causes of vulvar dermatoses; in 785 patients with a vulvar diseases who visited Ibn Rochd Hospital Centre, Casablanca between January 1991 and December 2002. The average age was 31 years (range 2 months to 81 years); 362 patients (41.52%) had vulvar pruritus, 273 patients (34.77%) had warts and 157 (20%) had one or more vulva ulcers. The most common infectious pathology was papillomavirus infection, found in 273 cases (34.77%), followed by vulvovaginal candidiases in 102 cases (12.99 %), syphilitic chancre in 18 cases (2.29%) and herpes genitalis in 17 cases (2.16%). The most common non-infectious pathology was vulvar dermatosis: 259 cases (32.99%); idiopathic pruritus vulvae: 61 cases (7.7%); and tumour-related conditions: 45 cases (5.6%). The frequency of infectious conditions was over 50% and these were generally sexually transmitted infections. PMID:15568459

Zouhair, K; El Ouazzani, T; El Omari, K; El Fajri, S; Lakhdar, H

2002-11-01

217

Langerhans' cell histiocytosis with multisystem involvement in an adult.  

PubMed

A 32-year-old Chinese woman presented for further investigation with a 6-year history of polyuria and polydipsia, a 4-year history of vulva ulceration and a 2-year history of gingival swelling. A biopsy of the vulva lesion showed diffuse infiltration of medium-sized cells with lobulated, grooved, vesicular nuclei. Occasional mitoses were present. The infiltrate of the cells showed reactivity with antibody to S-100 protein and CD1a, confirming the diagnosis of Langerhans' cell histiocytosis (LCH). Cephalic magnetic resonance imaging scanning revealed that an 8 x 7 x 8 mm3 large mass was located at the pituitary stalk. An X-ray film of the jaw showed sharply demarcated rarefaction of the right posterior portion of the mandible. In women with diabetes insipidus and genital ulcer, LCH should be considered in the differential diagnosis. PMID:17953644

Liu, Y H; Fan, X H; Fang, K

2007-11-01

218

Caenorhabditis elegans cog-1 Locus Encodes GTX\\/Nkx6.1 Homeodomain Proteins and Regulates Multiple Aspects of Reproductive System Development  

Microsoft Academic Search

The development of the reproductive system in Caenorhabditis elegans is a well-established model system for patterning and organogenesis. We report the characterization of the cog-1 gene, mutations in which cause novel phenotypes in late patterning in vulval lineages, establishment of the vulva–uterine connection, development and function of the spermathecal–uterine junction, and the development of vas deferens–proctodeal connection in the male.

Robert E. Palmer; Takao Inoue; David R. Sherwood; Lily I. Jiang; Paul W. Sternberg

2002-01-01

219

A v-erbB-Related Protooncogene, c-erbB-2, is Distinct from the c-erbB-1\\/Epidermal Growth Factor-Receptor Gene and is Amplified in a Human Salivary Gland Adenocarcinoma  

Microsoft Academic Search

From a human genomic library, we obtained six v-erbB-related DNA clones. A DNA probe prepared from one of the clones, lambda 107, hybridized to EcoRI fragments of 6.4 and 13 kilobase pairs of human DNA. Neither of these fragments was amplified in A431 vulva carcinoma cells, in which the gene encoding the epidermal growth factor receptor is amplified. In addition,

Kentaro Semba; Nobuyuki Kamata; Kumao Toyoshima; Tadashi Yamamoto

1985-01-01

220

Vulvar inflammation as the only clinical manifestation of Crohn disease in an 8-year-old girl.  

PubMed

Recognition of Crohn disease in children who present with cutaneous vulvar lesions as their initial clinical manifestation is often difficult. We report here the case of an 8-year-old girl with chronic vulvar edema, which on biopsy revealed granulomatous inflammation of the vulva. Further investigation and biopsy of the terminal ileum demonstrated similar findings and was consistent with a diagnosis of Crohn disease. PMID:20457677

Corbett, Shannon L; Walsh, Catharine M; Spitzer, Rachel F; Ngan, Bo-Yee; Kives, Sari; Zachos, Mary

2010-06-01

221

Physical Activity and Gynecologic Cancer Survivorship  

Microsoft Academic Search

\\u000a Gynecologic oncology involves the study of preinvasive disease and cancers of the vulva, vagina, cervix, uterus, ovaries,\\u000a and gestational trophoblastic disease. Endometrial cancer is the most common of the pelvic malignancies however, ovarian cancer\\u000a is the most lethal. The other gynecologic cancers have not been studied in relation to physical activity (PA) and prognosis,\\u000a and therefore are not included. Research

Karen M. Gil; Vivian E. von Gruenigen

222

Management of Extramammary Paget's Disease: A Case Report and Review of the Literature  

PubMed Central

Extramammary Paget's Disease (EMPD) is a rare condition of the skin that often involves the vulva, perianal region, scrotum, penis, and axilla. Although prognosis is generally favorable, it can be associated with neoplasms of the bladder, urethra, prostate, and rectum. This report presents a case of scrotal EMPD that failed treatment with imiquimod 5% cream and discusses benefits and complications of available treatment options. The variation of treatment success emphasizes the importance of further research. PMID:24349803

2013-01-01

223

A comparison of conception rates between artificial insemination and natural breeding of mares  

E-print Network

and their vulvas were washed with soap and water and then rinsed and dried. Semen was collected from each stallion before the season to determine total volume and sperm concentra- tion and motility. Since breedings were natural, the semen used for each breeding.... ) gives better conception rates than natural breeding is still questioned by some people. With today's expensive mares and prices of breedings, higher pregnancy rates improve the profitability of horse breeding farms. The farm's management practices...

Miller, John Arthur

1988-01-01

224

Comparative vaginal cytology of the estrous cycle of black-footed ferrets (Mustela nigripes), Siberian polecats (M. eversmanni), and domestic ferrets (M. putorius furo).  

PubMed

Vaginal cytology and vulva size were used to characterize the reproductive cycle of female black-footed ferrets (Mustela nigripes), Siberian polecats (M. eversmanni), and domestic ferrets (M. putorius furo). Emphasis was on black-footed ferrets because of the need to breed these critically endangered animals and on Siberian polecats because of the close taxonomic relationship to black-footed ferrets. Vaginal cytology of the 3 species of ferret is similar. Proestrus was characterized by an increasing percentage of superficial epithelial cells and enlargement of the vulva. During estrus, superficial cells were usually greater than or equal to 90% of epithelial cells in the vaginal lavage and after several days were fully keratinized. Neutrophils were more common during all stages of the estrous cycle in domestic ferrets than they were in the other species. Following copulation, percentage of superficial calls in the vagina declined and vulva swelling subsided. Large cells, probably of uterine symplasma origin, were observed in vaginal lavages following whelping or pseudopregnancy. Vaginal cytology is extremely useful in the reproductive management of black-footed ferrets and Siberian polecats. Knowledge of normal vaginal cytology could be applied to the diagnosis of female reproductive abnormalities in all 3 species. PMID:1554767

Williams, E S; Thorne, E T; Kwiatkowski, D R; Lutz, K; Anderson, S L

1992-01-01

225

Anisakiasis and Gastroallergic Reactions Associated with Anisakis pegreffii Infection, Italy  

PubMed Central

Human cases of gastric anisakiasis caused by the zoonotic parasite Anisakis pegreffii are increasing in Italy. The disease is caused by ingestion of larval nematodes in lightly cooked or raw seafood. Because symptoms are vague and serodiagnosis is difficult, the disease is often misdiagnosed and cases are understimated. PMID:23621984

Fazii, Paolo; De Rosa, Alba; Paoletti, Michela; Megna, Angelo Salomone; Glielmo, Antonio; De Angelis, Maurizio; Costa, Antonella; Meucci, Costantino; Calvaruso, Vito; Sorrentini, Italo; Palma, Giuseppe; Bruschi, Fabrizio; Nascetti, Giuseppe

2013-01-01

226

Orbital Rosai–Dorfman Disease in a Five-Year-Old Boy  

PubMed Central

Rosai–Dorfman disease (RDD) is characterized by histiocytic proliferation and massive cervical lymphadenopathy, although some patients have extra-nodal involvement. We report a case of extranodal RDD in a five-year-old child, initially misdiagnosed as orbital inflammatory disease and treated with oral steroids. A subsequent orbital biopsy three years later confirmed the diagnosis of Rosai Dorfman disease. PMID:22224025

Al-Moosa, Ashref J.; Behbehani, Raed S.; Hussain, Abdulmohsen E.; Ali, Abdullah E.

2011-01-01

227

Definitive Diagnosis of Mitochondrial Neurogastrointestinal Encephalomyopathy by Biochemical Assays  

Microsoft Academic Search

Background: Mitochondrial neurogastrointestinal en- cephalomyopathy (MNGIE) is caused by mutations in the gene encoding thymidine phosphorylase (TP). The clinical manifestations of MNGIE are recognizable and homogeneous, but in the early stages, the disease is often misdiagnosed. This study assesses the reliability of biochemical assays to diagnose MNGIE. Methods: We studied 180 patients with clinical features suggestive of MNGIE, 14 asymptomatic

Ramon Marti; Antonella Spinazzola; Saba Tadesse; Ichizo Nishino; Yutaka Nishigaki; Michio Hirano

228

Rapid diagnosis of varicella zoster virus infection in acute facial palsy.  

PubMed

Patients with zoster sine herpete and Ramsay Hunt syndrome without pathognomonic vesicles at the initial visit are often misdiagnosed with Bell's palsy and treated without antiviral agents. With PCR, we found that varicella zoster virus genomes were frequently detectable in auricular skin exudate from patients with zoster sine herpete or Ramsay Hunt syndrome before the appearance of vesicles. PMID:9781562

Murakami, S; Honda, N; Mizobuchi, M; Nakashiro, Y; Hato, N; Gyo, K

1998-10-01

229

Optimal Outcome in Individuals with a History of Autism  

ERIC Educational Resources Information Center

Background: Although autism spectrum disorders (ASDs) are generally considered lifelong disabilities, literature suggests that a minority of individuals with an ASD will lose the diagnosis. However, the existence of this phenomenon, as well as its frequency and interpretation, is still controversial: were they misdiagnosed initially, is this a…

Fein, Deborah; Barton, Marianne; Eigsti, Inge-Marie; Kelley, Elizabeth; Naigles, Letitia; Schultz, Robert T.; Stevens, Michael; Helt, Molly; Orinstein, Alyssa; Rosenthal, Michael; Troyb, Eva; Tyson, Katherine

2013-01-01

230

First Detection of Human Dirofilariasis in South Africa  

PubMed Central

Humans are occasionally inadvertently infected with dirofilariae, the zoonotic nematodes. We report two cases of human dirofilariasis in South Africa, an area apparently non-endemic for this infection. Dirofilariasis is frequently misdiagnosed, so increased awareness of this entity in areas that are non-endemic is essential for prevention of inappropriate investigations and invasive therapy.

Moodley, Krishnee; Govind, Chetna N.; Peer, Abdool K.C.; van der Westhuizen, Marissa; Parbhoo, Dharmesh; Sun, Lisa Ming; du Plessis, Desiree C.; Frean, John A.

2015-01-01

231

Dissociative Disorders in Children: Behavioral Profiles and Problems.  

ERIC Educational Resources Information Center

Clinical research has established a connection between childhood trauma and the development of dissociative disorders in adults. Pathological dissociation produces a range of symptoms and behaviors such as amnesias, rapid shifts in mood and behavior, and auditory and visual hallucinations. Many of these symptoms are misdiagnosed as attention,…

Putnam, Frank W.

1993-01-01

232

Anterior sacral meningocele mimicking ovarian cyst: a case report.  

PubMed

Anterior sacral meningocele (ASM) is a rare congenital anomaly, characterized by herniation through a defect in the anterior aspect of the sacrum. We reported a case of ASM associated with neurofibromatosis, which was mimicking a complex ovarian cyst in ultrasonography. ASM can easily be misdiagnosed as an ovarian cyst and needle aspiration can cause intracranial hypotension syndrome or even death. PMID:23486628

Polat, Ahmet Veysel; Belet, Umit; Aydin, Ramazan; Katranci, Seckin

2013-03-01

233

Depression on Dialysis  

Microsoft Academic Search

Depression is the most common psychopathological condition among patients with end-stage renal disease (ESRD), yet it is still under-recognized and misdiagnosed. Depression reduces quality of life and has a negative clinical impact upon sufferers with chronic illness, including ESRD. This article discusses the negative effects of depression among the ESRD population treated with dialysis, the prevalence of the condition, the

Joseph Chilcot; David Wellsted; Maria Da Silva-Gane; Ken Farrington

2008-01-01

234

Angiolymphoid hyperplasia with eosbvophilia-case report.  

PubMed

Angiolymphoid hyperplasia with eosinophilia (ALHE) is a benign condition characterized by subcutaneous lesions in the head-neck region. It is frequently misdiagnosed as a malignant lesion. Knowledge of the existence of the disease and pathological interpretation are requisites for early diagnosis. We present a case report and review of the literature. PMID:23119661

Mankekar, G; Chainani, G N; Bhatt, C; Sha, T M

2000-04-01

235

Segmental ulcerated perineal hemangioma of infancy: a complex case of PELVIS syndrome successfully treated using a multidisciplinary approach.  

PubMed

We report a case of PELVIS (perineal hemangioma, external genital malformations, lipomyelomeningocele, vesicorenal abnormalities, imperforate anus and skin tag) syndrome in which hemangioma in the perineal area was misdiagnosed at birth as diaper rash. Investigations revealed associated vesicorenal and spinal abnormalities. We emphasize careful diagnosis of suspicious lesions at birth and confirm the successful use of propranolol in treating ulcerated segmental hemangiomas. PMID:23278237

Kaushik, Shivani B; Kwatra, Shawn G; McLean, Thomas W; Powers, Alexander; Atala, Anthony J; Yosipovitch, Gil

2013-01-01

236

Amatoxin-Containing Mushroom (Lepiota brunneoincarnata) Familial Poisoning.  

PubMed

Serious to fatal toxicity may occur with amanitin-containing mushrooms ingestions. A Lepiota brunneoincarnata familial poisoning with hepatic toxicity is reported. In such poisonings, acute gastroenteritis may be firstly misdiagnosed leading to delay in preventing liver dysfunction by silibinin or penicillin G. Mushroom picking finally requires experience and caution. PMID:25831030

Varvenne, David; Retornaz, Karine; Metge, Prune; De Haro, Luc; Minodier, Philippe

2015-04-01

237

Differentiating Conduct Disorder from Depressive Disorders in School Age Children.  

ERIC Educational Resources Information Center

Due to similarities in symptomatology, childhood depression has often been misdiagnosed as conduct disorder. Differentiating between the two disorders would help to direct the appropriate interventions for each disorder. Children (N=48) between the ages of 6 and 13 years and their parents participated in a study designed to analyze variables which…

King, Richard B.; And Others

238

Identifying Hearing Loss in Young Children: Technology Replaces the Bell  

ERIC Educational Resources Information Center

Hearing loss can too easily be misdiagnosed or overlooked by providers serving young children. Parents and professionals may observe a language delay--an "invisible" condition--while failing to identify the underlying cause. Otoacoustic emissions (OAE) hearing screening technology, used extensively with newborns, is becoming an essential tool,…

Eiserman, William; Shisler, Lenore

2010-01-01

239

Cystic extra-axial cavernoma of the cerebellopontine angle  

Microsoft Academic Search

Besides acoustic neuromas, the cerebellopontine angle harbors a wide variety of masses, named “nonacoustic neuroma tumors,” as a whole. Although magnetic resonance imaging has much improved our ability to differentiate among posterior fossa lesions, misdiagnoses may still occur when facing rare, controversial cases.

Andrea Brunori; Francesco Chiappetta

1996-01-01

240

Endometrial metaplasias and reactive changes: a spectrum of altered differentiation  

Microsoft Academic Search

Endometrial metaplasias and changes (EMCs) are conditions frequently overlooked and misdiagnosed. The aim of this review is to update current issues and provide a classification with a practical clinicopathological approach. Hormonal or irritative stimuli are the main inducing factors of EMCs, although some metaplasias have a mutational origin. EMCs vary from reactive, degenerative lesions to those able to associate with

Alina Nicolae; Ovidiu Preda; Francisco F Nogales

2010-01-01

241

Metastatic breast neuroendocrine tumor from the rectum.  

PubMed

Metastatic breast neuroendocrine tumor is an exceedingly rare entity. They are commonly initially misdiagnosed as primary breast carcinoma. Correct diagnosis of this tumor is crucial owing to the different clinical management from primary breast tumor. We report an additional case of metastatic breast neuroendocrine tumor from the rectum that behaved in an aggressive fashion and failed to respond to chemotherapy treatment. PMID:22729125

Al-Maghrabi, Jaudah A; Zekri, Jamal

2012-06-01

242

Sentence Repetition as a Measure of Morphosyntax in Monolingual and Bilingual Children  

ERIC Educational Resources Information Center

Bilingual children are frequently misdiagnosed as having Specific Language Impairment (SLI). Misdiagnosis may be minimized by tests with high degrees of sensitivity and specificity. The current study used a new test, the School-Age Sentence Imitation Test-English 32 (SASIT-E32), to investigate sentence repetition in monolingual and bilingual…

Komeili, Mariam; Marshall, Chloe R.

2013-01-01

243

High-Performing Families: Causes, Consequences, and Clinical Solutions. The Family Psychology and Counseling Series.  

ERIC Educational Resources Information Center

This book explores the dilemma of the increasing obsession with work and the resulting imbalances between career and family life. Through theoretical frameworks and case examples it discusses the negative consequences of the societal phenomena of over-work and over-dedication to careers, which have been misdiagnosed or ignored by mental health…

Robinson, Bryan E., Ed.; Chase, Nancy D., Ed.

244

A serum autoantibody marker of neuromyelitis optica: distinction from multiple sclerosis  

Microsoft Academic Search

BACKGROUND: Neuromyelitis optica is an inflammatory demyelinating disease with generally poor prognosis that selectively targets optic nerves and spinal cord. It is commonly misdiagnosed as multiple sclerosis. Neither disease has a distinguishing biomarker, but optimum treatments differ. The relation of neuromyelitis optica to optic-spinal multiple sclerosis in Asia is uncertain. We assessed the capacity of a putative marker for neuromyelitis

V. A. Lennon; D. M. Wingerchuk; T. J. Kryzer; S. J. Pittock; C. F. Lucchinetti; K. Fujihara; I. Nakashima; B. G. Weinshenker

2004-01-01

245

Neosporosis in animals-the last five years  

Technology Transfer Automated Retrieval System (TEKTRAN)

Neospora caninum is a protozoan parasite of animals. Until 1988, it was misdiagnosed as Toxoplasma gondii. Since its first recognition in 1984 in dogs and the description of a new genus and species Neospora caninum in 1988, neosporosis has emerged as a serious disease of cattle and dogs worldwide. ...

246

Solitary fibrous tumor (SFT) of the pelvis  

Microsoft Academic Search

Solitary fibrous tumors (SFTs) are well recognized in the pleura, but their occurrence at other sites has only become appreciated in recent years, as a consequence of which extrapleural examples often go unrecognized and misdiagnosed. Because of their rarity, overall experience concerning this tumor has not been significant and reports detailing radiological findings are few. We herein report an unusual

Shiu Yan J. Wat; Monalisa Sur; Kavita Dhamanaskar

2008-01-01

247

Male Anorexia Nervosa: A New Focus.  

ERIC Educational Resources Information Center

Although anorexia nervosa affects over one million males yearly, it is often misdiagnosed or overlooked by mental health and medical practitioners. This article brings the problem to the forefront and outlines features that are unique to these males. Greater recognition of the disorder can lead to more accurate diagnoses and, subsequently, better…

Crosscope-Happel, Cindy; Hutchins, David E.; Getz, Hildy G.; Hayes, Gerald L.

2000-01-01

248

North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition Consensus Statement on the Diagnosis and Management of Cyclic Vomiting Syndrome  

Microsoft Academic Search

Cyclic vomiting syndrome (CVS) is a disorder noted for its unique intensity of vomiting, repeated emergency department visits and hospitalizations, and reduced quality of life. It is often misdiagnosed due to the unappreciated pattern of recurrence and lack of confirmatory testing. Because no accepted approach to management has been established, the task force was charged to develop a report on

B UK Li; Frank Lefevre; Gisela G Chelimsky; Richard G Boles; Susanne P Nelson; Donald W Lewis; Steven L Linder; Robert M Issenman; Colin D Rudolph

2008-01-01

249

Transient synovitis of the hip as a complication of chickenpox in infant: Case study  

PubMed Central

Chickenpox has many rare complications; transient synovitis is one of the very painful and self-limiting rare complications. This patient suffered from transient synovitis associated with chickenpox. After being diagnosed, it was managed by diclofenac sodium suppositories. Physicians must be able to correlate all of the possible complications of chickenpox in order to avoid misdiagnoses. PMID:23960801

Alomar, Muaed Jamal

2012-01-01

250

Full Body Gait Analysis May Improve Diagnostic Discrimination Between Hereditary Spastic Paraplegia and Spastic Diplegia: A Preliminary Study  

ERIC Educational Resources Information Center

Hereditary spastic paraplegia (HSP) and spastic diplegia (SD) patients share a strong clinical resemblance. Thus, HSP patients are frequently misdiagnosed with a mild form of SD. Clinical gait analysis (CGA) has been highlighted as a possible tool to support the differential diagnosis of HSP and SD. Previous analysis has focused on the lower-body…

Bonnefoy-Mazure, A.; Turcot, K.; Kaelin, A.; De Coulon, G.; Armand, S.

2013-01-01

251

Risk Factors and Laboratory Diagnostics for Post Renal Transplant Tuberculosis: A Case-Controlled, CountryWide Study on Definitive Cases  

Microsoft Academic Search

Background: Tuberculosis (TB) is a common cause of morbidity and mortality in renal transplant recipients. It is usually misdiagnosed because of lack of medical awareness and its infrequency in renal transplant recipients. Materials and Methods: 44 cases (0.3%) with post-transplant TB out of 12820 patients who had renal transplants performed between 1984 to 2003 were found from the hospital records

A Basiri; SM Hosseini Moghaddam; N Simforoosh; B Einollahi; M Hosseini; A Firouzan; F Pourrezagholi; M Nafar; G Pourmand; A Taghizadeh; E Ahmad; M Yazdani; A Nasrollahi; A Shamsa; R Mahdavi; R Esmaeili; Z Mohammadi

252

CARBON MONOXIDE POISONING--A PUBLIC HEALTH PERSPECTIVE.  

EPA Science Inventory

Carbon monoxide (CO) may be the cause of more than one-half of the fatal poisonings reported in many countries: fatal cases also are grossly under-reported or mis-diagnosed by medical professionals. Therefore, the precise number of individuals who have suffered from CO intoxicat...

253

Acute traumatic L5–S1 spondylolisthesis: a case report  

Microsoft Academic Search

Study Design: Case report of a patient treated surgically 2 months after sustaining a misdiagnosed acute traumatic lumbosacral dislocation is presented. Objectives: The aims is to report in full about an uncommon case of anterior traumatic L5–S1 spondylolisthesis treated successfully with combined posterior stabilization and anterior fusion. Summary of background data: Review of literature shows that traumatic lumbosacral dislocations and its

M. Reinhold; C. Knop; M. Blauth

2006-01-01

254

Acquired digital fibrokeratoma: a case report.  

PubMed

Acquired digital fibrokeratomas are benign, rare tumors that develop most commonly on the fingers. They can have an appearance of a rudimentary supernumerary digit or be misdiagnosed as a more common condition, such as verruca vulgaris. There are no case reports described in the plastic surgery literature. We are reporting a case that presented to our institution recently. PMID:24051460

Yu, Deborah; Morgan, Raymond F

2015-03-01

255

Advanced Clinical Interpretation of the WAIS-IV and WMS-IV: Prevalence of Low Scores Varies by Level of Intelligence and Years of Education  

ERIC Educational Resources Information Center

Clinicians can use the base rates of low scores in healthy people to reduce the likelihood of misdiagnosing cognitive impairment. In the present study, base rates were developed for the Wechsler Adult Intelligence Scale-Fourth Edition (WAIS-IV) and Wechsler Memory Scale-Fourth Edition (WMS-IV) using 900 healthy adults and validated on 28 patients…

Brooks, Brian L.; Holdnack, James A.; Iverson, Grant L.

2011-01-01

256

Diagnosis, Dogmatism, and Rationality.  

ERIC Educational Resources Information Center

Presents findings suggesting that misdiagnoses frequently stem from flaws in human information processing, particularly in collecting and using information. Claims that improved diagnostic tools will not remedy the problem. Drawing on the work of Karl Popper and Robin Collingwood, proposes operational principles to ensure a rational diagnostic…

Rabinowitz, Jonathan; Efron, Noah J.

1997-01-01

257

Neosporosis in dogs  

Technology Transfer Automated Retrieval System (TEKTRAN)

Neospora caninum is a protozoan parasite of animals. Until 1988, it was misdiagnosed as Toxoplasma gondii. Since its first recognition in 1984 and the description of a new genus and species Neospora caninum in 1988, neosporosis has emerged as a serious disease of dogs and cattle worldwide. Additiona...

258

The Effectiveness of Mindfulness Training on the Grieving Process and Emotional Well-Being of Chronic Pain Patients  

Microsoft Academic Search

Losses in relationships, work, and other areas of life often accompany the physical discomfort of chronic pain. Often the depth and intensity of the grief associated with chronic pain are overlooked or possibly misdiagnosed and treated as depression. We used an 8-week mindfulness meditation program to determine its effectiveness in addressing the grieving process among 39 patients diagnosed with chronic

David Sagula; Kenneth G. Rice

2004-01-01

259

Living with the Active Alert Child: Groundbreaking Strategies for Parents. Third Edition.  

ERIC Educational Resources Information Center

Bright, controlling, fearful, and highly energetic, active alert children are frequently misdiagnosed as hyperactive or learning disabled. This book offers guidance for the special challenge of parenting the active alert infant, child, and adolescent. Part 1 of the book profiles the active alert child and examines 11 traits that characterize…

Budd, Linda S.

260

Tracking a Medically Important Spider: Climate Change, Ecological Niche Modeling, and the Brown Recluse (Loxosceles reclusa)  

Microsoft Academic Search

Most spiders use venom to paralyze their prey and are commonly feared for their potential to cause injury to humans. In North America, one species in particular, Loxosceles reclusa (brown recluse spider, Sicariidae), causes the majority of necrotic wounds induced by the Araneae. However, its distributional limitations are poorly understood and, as a result, medical professionals routinely misdiagnose brown recluse

Erin E. Saupe; Monica Papes; Paul A. Selden; Richard S. Vetter; Corrie Moreau

2011-01-01

261

THEORETICAL ADVANCES Joint feature selection and classification for taxonomic problems  

E-print Network

to a taxonomic problem involving species of suckers in the genus Carpiodes. The results confirm the necessity have traditionally been misdiagnosed as C. carpio but are in fact more close to C. cyprinus. We also Carpiodes. The results look promising: the proposed method not only learned the classifier that well

Bart Jr., Henry L. "Hank"

262

Multilocular peritoneal inclusion cyst mimicking an ovarian tumor: A case report  

PubMed Central

Peritoneal inclusion cysts are uncommon abdominopelvic cysts seen in perimenopausal women. It is often misdiagnosed clinically as an ovarian tumor due to similar presentation and mimicking findings on radiology. We describe a perimenopausal woman presenting with pelvic mass. Her clinical finding on radiology suggested an ovarian tumor; however, biopsy revealed it as peritoneal inclusion cysts. We discuss the possible ways to avoid such mistakes.

Singh, Anju; Sehgal, Alka; Mohan, Harsh

2015-01-01

263

A Preliminary Report on the English Phonology of Typically Developing English-Mandarin Bilingual Preschool Singaporean Children  

ERIC Educational Resources Information Center

Background: There are no published data on typical phonological development for Singaporean children. There is therefore the risk that children's speech in Singapore may be misdiagnosed or that clinicians may set goals erroneously. Aims: This paper reports a preliminary study on the English phonology of typically developing 4;0-4;5-year-old…

En, Lydea Gn Wei; Brebner, Chris; McCormack, Paul

2014-01-01

264

Zika Virus Infection Acquired During Brief Travel to Indonesia  

PubMed Central

Zika virus infection closely resembles dengue fever. It is possible that many cases are misdiagnosed or missed. We report a case of Zika virus infection in an Australian traveler who returned from Indonesia with fever and rash. Further case identification is required to determine the evolving epidemiology of this disease. PMID:23878182

Kwong, Jason C.; Druce, Julian D.; Leder, Karin

2013-01-01

265

Primary Cardiac Lymphoma: Helical CT Findings and Radiopathologic Correlation  

SciTech Connect

Primary tumors of the heart are extremely rare.Clinical manifestations are nondiagnostic and the patients are often misdiagnosed. Magnetic resonance imaging and echocardiography are standard in this diagnostic workup. We report a case of a man with acromegaly, dysphagia, chest pain and weight loss. An invasive cardiac mass was diagnosed by helical-CT. Autopsy demonstrated a B-cell aggressive lymphoma.

Marco de Lucas, Enrique, E-mail: radmle@humv.es; Pagola, Miguel Angel [HospitalUniversitario Marques de Valdecilla, Santander, Department of Radiology (Spain); Fernandez, Fidel [Hospital Universitario Marques de Valdecilla, Santander, Department ofPathology (Spain); Lastra, Pedro; Delgado, M. Luisa Ruiz; Sadaba, Pablo [HospitalUniversitario Marques de Valdecilla, Santander, Department of Radiology (Spain); Pinto, Jesus [Hospital Universitario Marques de Valdecilla, Santander, Department ofPathology (Spain); Ballesteros, Ma Angeles [Hospital Universitario Marques de Valdecilla, Santander, Department of Intensive Care Medicine (Spain); Ortiz, Antonio [HospitalUniversitario Marques de Valdecilla, Santander, Department of Radiology (Spain)

2004-03-15

266

Childhood Vestibular Disorders: A Tutorial  

ERIC Educational Resources Information Center

There is a growing body of evidence that childhood disorders affecting the vestibular system, although rare, do exist. Describing symptoms associated with the vestibular mechanism for children may be difficult, resulting in misdiagnosing or under-diagnosing these conditions. The pathophysiology, symptoms, and management options of the more common…

Mehta, Zarin; Stakiw, Daria B.

2004-01-01

267

Disc excavation in dominant optic atrophy  

Microsoft Academic Search

ObjectiveIn patients with dominant optic atrophy (DOA, Kjer type), excavation of the optic nerve develops, and these patients may be misdiagnosed as having normal tension glaucoma (NTG). This study examined disc morphologic features in patients with DOA and explored features that help distinguish this condition from NTG.

Annick V Fournier; Karim F Damji; David L Epstein; Stephen C Pollock

2001-01-01

268

Detached ciliary tufts in the epididymis: A lesson in applied anatomy  

Microsoft Academic Search

We report a case of detached ciliary tufts (DCTs) discovered in the aspirate from an epididymal cyst in a 30-year-old man undergoing epididymal exploration for obstructive azoospermia. The specimen was initially misdiagnosed as a parasite due to its appearance and spontaneous motion on fresh smear. Since standard urology and histology texts identify ciliated cells only in the efferent duct of

Craig V. Comiter; Carl O. Bruning; Abraham Morgentaler

1995-01-01

269

At-Risk Youngsters: Methods That Work.  

ERIC Educational Resources Information Center

This paper examines problems faced by youngsters at risk of failure in school, and discusses methods for helping them succeed in educational programs. At-risk youngsters confront many problems in school and in mainstream society, and are frequently misidentified, misdiagnosed, and improperly instructed. Problems faced by at-risk youngsters…

Obiakor, Festus E.

270

Dehydration, Heat Stroke, or Hyponatremia? The Recognition, Treatment, and Prevention of Hyponatremia Caused by High Exercise Outdoor Activities.  

ERIC Educational Resources Information Center

Hyponatremia (severe sodium depletion) has symptoms similar to heat exhaustion and heat stroke and can easily be misdiagnosed. The number of wilderness users and extreme adventure activities has increased in recent years, and more cases are being diagnosed. Given that a 1993 study found that 1 in 10 cases of heat-related illnesses were…

Cochran, Brent

271

Lyme Disease: Implications for Health Educators.  

ERIC Educational Resources Information Center

Lyme disease may be one of the most commonly misdiagnosed diseases of this decade. Health educators should be knowledgeable about this new disease and be able to share with the public information about prevention, early signs and symptoms, and treatment of the disease (Author/IAH)

Harbit, Maryanne Drake; Willis, Dawn

1990-01-01

272

A plastic whistle incarcerated in bronchus diagnosed fourteen years after ‘swallowed’: a case report  

PubMed Central

Tracheobronchial foreign body aspiration (FBA) is a common disease in pre-school children but easily overlooked by physicians. In this article, we report a case with bronchial stenosis that is not typical and misdiagnosed for 14 years, in the end bronchoscopy retrieval was successfully performed after adequate preparation. Pitfalls and recommendations in diagnosis and management of FBA are briefly included. PMID:24977017

Wang, Xin

2014-01-01

273

Abdominal emergencies in the geriatric patient  

PubMed Central

Abdominal pain is one of the most frequent reasons that elderly people visit the emergency department (ED). In this article, we review the deadliest causes of abdominal pain in this population, including mesenteric ischemia, abdominal aortic aneurysm, and appendicitis and potentially lethal non-abdominal causes. We also highlight the pitfalls in diagnosing, or rather misdiagnosing, these clinical entities. PMID:25635203

2014-01-01

274

Geometry of magnetosonic shocks and plane-polarized waves: Coplanarity Variance Analysis (CVA)  

E-print Network

degeneracy of the covariance matrix present at planar structures to find a consistent normal of relatively abrupt reorientations of the magnetic field and other fluid variables. For historical reasons, the eigenvalues of their covariance matrix are usually not degenerate; accordingly, CVA does not misdiagnose TDs

Scudder, Jack

275

Metoclopramide-induced oculogyric crisis presenting as encephalitis in a young girl  

PubMed Central

Drug-related dystonic reactions are not uncommon and often misdiagnosed as encephalitis, seizures, tetanus, tetany, etc. Eliciting thorough history is important to avoid unnecessary investigations and treatments as these are potentially reversible reactions. Metoclopramide-induced oculogyric crisis is described in this case report. PMID:22529490

Arumugam, Jayavardhana; Vijayalakshmi, A.M.

2012-01-01

276

Assessment of obsessive–compulsive disorder: A review  

Microsoft Academic Search

Obsessive–compulsive disorder (OCD) affects approximately 2–3% of the adult population and is considered a debilitating and costly disorder, with associated impairments spanning the social, occupational, and familial domains. Although effective treatments of OCD exist, many individuals who suffer from OCD go undiagnosed or misdiagnosed, preventing them from obtaining appropriate treatment. As a result, making improvements to the assessment and diagnosis

Kristen Grabill; Lisa Merlo; Danny Duke; Kelli-Lee Harford; Mary L. Keeley; Gary R. Geffken; Eric A. Storch

2008-01-01

277

Submission of Fish for Diagnostic Evaluation1 RuthEllen Klinger and Ruth Francis-Floyd2  

E-print Network

FA55 Submission of Fish for Diagnostic Evaluation1 RuthEllen Klinger and Ruth Francis-Floyd2 1 Determining the cause of a fish's illness and death can be difficult and frustrating for anyone who works with fish. Disease problems are commonly misdiagnosed and fish are often incorrectly treated with over

Watson, Craig A.

278

A Patient Presenting with Concurrent Testis Torsion and Epididymal Leiomyoma  

PubMed Central

Leiomyomas are the second most common tumors of epididymis. Patients with leiomyomas are sometimes misdiagnosed with testicular tumors. A Case of a patient with a scrotal mass presenting with testicular torsion is reported. Concurrent occurrence of testicular torsion and epididymal leiomyoma is an extremely rare condition. PMID:23781386

Arpali, E.; Tok, A.

2013-01-01

279

Development of an engineered ‘bioluminescent’ reporter phage for the detection of bacterial blight of crucifers  

Technology Transfer Automated Retrieval System (TEKTRAN)

Bacterial blight, caused by the phytopathogen Pseudomonas cannabina pv. alisalensis, is an emerging disease afflicting important members of the Brassica family. The disease is often misdiagnosed as peppery leaf spot, a much less severe disease caused by the closely related pathogen Pseudomonas syrin...

280

Pseudoasthma: When Cough, Wheezing, and Dyspnea Are Not Asthma  

Microsoft Academic Search

Although asthma is the most common cause of cough, wheeze, and dyspnea in children and adults, asthma is often attributed inappropriately to symptoms from other causes. Cough that is misdiagnosed as asthma can occur with pertussis, cystic fibrosis, primary ciliary dyskinesia, airway abnormalities such as tracheomalacia and bronchomalacia, chronic purulent or suppurative bronchitis in young chil- dren, and habit-cough syndrome.

Miles Weinberger; Mutasim Abu-Hasan

2010-01-01

281

Control of vulval competence and centering in the nematode Oscheius sp. 1 CEW1.  

PubMed Central

To compare vulva development mechanisms in the nematode Oscheius sp. 1 to those known in Caenorhabditis elegans, we performed a genetic screen for vulva mutants in Oscheius sp. 1 CEW1. Here we present one large category of mutations that we call cov, which affect the specification of the Pn.p ventral epidermal cells along the antero-posterior axis. The Pn.p cells are numbered from 1 to 12 from anterior to posterior. In wild-type Oscheius sp. 1 CEW1, the P(4-8).p cells are competent to form the vulva and the progeny of P(5-7).p actually form the vulva, with the descendants of P6.p adopting a central vulval fate. Among the 17 mutations (defining 13 genes) that we characterize here, group 1 mutations completely or partially abolish P(4-8).p competence, and this correlates with early fusion of the Pn.p cells to the epidermal syncytium. In this group, we found a putative null mutation in the lin-39 HOM-C homolog, the associated phenotype of which could be weakly mimicked by injection of a morpholino against Osp1-lin-39 in the mother's germ line. Using cell ablation in a partially penetrant competence mutant, we show that vulval competence is partially controlled by a gonadal signal. Most other mutants found in the screen display phenotypes unknown in C. elegans. Group 2 mutants show a partial penetrance of Pn.p competence loss and an abnormal centering of the vulva on P5.p, suggesting that these two processes are coregulated by the same pathway in Oscheius sp. 1. Group 3 mutants display an enlarged competence group that includes P3.p, thus demonstrating the existence of a specific mechanism inhibiting P3.p competence. Group 4 mutants display an abnormal centering of the vulval pattern on P7.p and suggest that a specific mechanism centers the vulval pattern on a single Pn.p cell. PMID:12586702

Louvet-Vallée, Sophie; Kolotuev, Irina; Podbilewicz, Benjamin; Félix, Marie-Anne

2003-01-01

282

Cutaneous Gnathostomiasis with Recurrent Migratory Nodule and Persistent Eosinophilia: a Case Report from China  

PubMed Central

The present study reports a human case of cutaneous gnathostomiasis with recurrent migratory nodule and persistent eosinophilia in China. A 52-year-old woman from Henan Province, central China, presented with recurrent migratory reddish swelling and subcutaneous nodule in the left upper arm and on the back for 3 months. Blood examination showed eosinophila (21.2%), and anti-sparganum antibodies were positive. Skin biopsy of the lesion and histopathological examinations revealed dermal infiltrates of eosinophils but did not show any parasites. Thus, the patient was first diagnosed as sparganosis; however, new migratory swellings occurred after treatment with praziquantel for 3 days. On further inquiring, she recalled having eaten undercooked eels and specific antibodies to the larvae of Gnathostoma spinigerum were detected. The patient was definitely diagnosed as cutaneous gnathostomiasis caused by Gnathostoma sp. and treated with albendazole (1,000 mg/day) for 15 days, and the subsequent papule and blister developed after the treatment. After 1 month, laboratory findings indicated a reduced eosinophil count (3.3%). At her final follow-up 18 months later, the patient had no further symptoms and anti-Gnathostoma antibodies became negative. Conclusively, the present study is the first report on a human case of cutaneous gnathostomiasis in Henan Province, China, based on the past history (eating undercooked eels), clinical manifestations (migratory subcutaneous nodule and persistent eosinophilia), and a serological finding (positive for specific anti-Gnathostoma antibodies). PMID:24039291

Cui, Jing; Wang, Ye

2013-01-01

283

Zoonotic helminths affecting the human eye  

PubMed Central

Nowaday, zoonoses are an important cause of human parasitic diseases worldwide and a major threat to the socio-economic development, mainly in developing countries. Importantly, zoonotic helminths that affect human eyes (HIE) may cause blindness with severe socio-economic consequences to human communities. These infections include nematodes, cestodes and trematodes, which may be transmitted by vectors (dirofilariasis, onchocerciasis, thelaziasis), food consumption (sparganosis, trichinellosis) and those acquired indirectly from the environment (ascariasis, echinococcosis, fascioliasis). Adult and/or larval stages of HIE may localize into human ocular tissues externally (i.e., lachrymal glands, eyelids, conjunctival sacs) or into the ocular globe (i.e., intravitreous retina, anterior and or posterior chamber) causing symptoms due to the parasitic localization in the eyes or to the immune reaction they elicit in the host. Unfortunately, data on HIE are scant and mostly limited to case reports from different countries. The biology and epidemiology of the most frequently reported HIE are discussed as well as clinical description of the diseases, diagnostic considerations and video clips on their presentation and surgical treatment. Homines amplius oculis, quam auribus credunt Seneca Ep 6,5 Men believe their eyes more than their ears PMID:21429191

2011-01-01

284

Functional expression and characterization of a cytosolic copper/zinc-superoxide dismutase of Spirometra erinacei.  

PubMed

Spirometra erinacei is a pseudophyllidean tapeworm which inhabits the intestines of cats and dogs. The infections are usually asymptomatic in these animals, but the infection of the plerocercoid larvae of the parasite, spargana, cause sparganosis in other vertebrates, including human. In this study, we identified a gene encoding the copper/zinc-superoxide dismutase of S. erinacei (SeCuZn-SOD) and partially characterized the biochemical and functional properties of the enzyme. The open reading frame of SeCuZnSOD was 465 bp that encodes 154 amino acids. The characteristic amino acid residues and motifs required for coordinating copper and zinc enzymatic function were well conserved. The genomic length of the SeCuZnSOD was 1,985 bp consisting of three exons that are separated by two introns. SeCuZnSOD is a typical cytosolic form which shares similar biochemical properties, including broad pH optima and inhibition profile by KCN and H(2)O(2), with cytosolic Cu/Zn-SODs of other organisms. SeCuZnSOD was functionally expressed in both S. erinacei plerocercoid larvae and adult worms, and its expression level was significantly increased when the plerocercoid larvae were treated with paraquat. The enzyme may play essential roles for survival of the parasite not only by protecting itself from endogenous oxidative stress, but also by detoxifying oxidative killing of the parasite by host immune effector cells. PMID:20076970

Li, Ai-Hua; Na, Byoung-Kuk; Ahn, Sung-Kyu; Cho, Shin-Hyeong; Pak, Jhang-Ho; Park, Yun-Kyu; Kim, Tong-Soo

2010-02-01

285

Description of Hemicaloosia graminis n. sp. (Nematoda: Caloosiidae) Associated with Turfgrasses in North and South Carolina, USA  

PubMed Central

A new nematode species was discovered during a diversity survey of plant-parasitic nematodes on turfgrass conducted in North and South Carolina in 2010 and 2011. It is described herein as Hemicaloosia graminis n. sp. and is characterized by two annuli in the lip region, one lateral line, body 610.0–805.0 ?m long, stylet 65.0–74.6 ?m long, vulva at 84.1% –85.8% of the body , 254–283 annuli, vulva at the 38–53rd annulus from tail terminus, 12–14 annuli between vulva and anus, tail elongate-pointed, 67.5–84.8 ?m long in females and spicule straight, 31.0 ?m long, caudal alae well developed, two lateral lines in males. The newly described species is morphologically closest to H. paradoxa, but has a longer stylet (65.0–74.6 vs 61.0–65.0 ?m) and a higher V-value (84.1–85.8 vs 78.1–84.0%), less RV (38–53 vs 50–56), higher RVan (12–14 vs 10) in females, and a shorter tail (30.1 vs 36.7 ?m) and more anteriorly located excretory pore (105.9 vs 140.0 ?m) in the male. It was easily differentiated from other species based on near-full-length small subunit rRNA gene (SSU) and ITS1 sequences. Phylogenetic analysis from SSU supports placement in a monophyletic clade with the genus Caloosia. An identification key and a table of distinguishing characteristics are presented for all seven species of Hemicaloosia. PMID:23482701

Zeng, Yongsan; Ye, Weimin; Tredway, Lane; Martin, Samuel; Martin, Matt

2012-01-01

286

Receptivity of female Neohelice granulata (Brachyura, Varunidae): different strategies to maximize their reproductive success in contrasting habitats  

NASA Astrophysics Data System (ADS)

The extent of the receptive period may determine the mating strategies employed by female crabs to obtain mates. Here, we studied the receptivity of female Neohelice granulata (Dana, 1851) in the laboratory, including the form of the vulvae and the anatomy of the seminal receptacle (SR). We examined the factors that influence the duration of receptivity by comparing two populations inhabiting contrasting habitats: Mar Chiquita Coastal lagoon (MCL), which is an oligo-polyhaline estuary, and San Antonio Oeste (SAO), which is an eu-hyperhaline marine bay. Non-receptive females have immobile vulva opercula, while receptive females have mobile opercula. Histological sections of the SR showed that the degree of epithelium secretions was associated with the receptive stage of females, and they may be involved in the maintenance of viable sperm and in the dehiscence of spermatophores. The existence of a special tissue at the junction of the oviduct and the SR was described and proposed as an internal mechanism influencing the timing of ovulation. The duration of receptivity was dependent on the SR load and the capacity to lay eggs. Thus, females with empty SR exhibited longer receptivity and did not lay eggs, while those with full SR exhibited shorter receptivity and always laid eggs. Interpopulation differences showed that females from SAO had shorter receptivity and heavier SR and laid eggs more frequently than females from MCL. Based on our results, we suggest that N. granulata females can adjust the duration of their receptivity and control the moment of fertilization according to different internal mechanisms related to the morphology of the vulvae, the fullness of the SR and anatomical attributes of the SR. An important consequence of this control is greater sperm competition. The extent of the receptive period and the number of times that a female could become receptive in a single reproductive season may also depend on the habitat characteristics.

Sal Moyano, María Paz; Luppi, Tomás; Gavio, María Andrea; Vallina, Micaela; McLay, Colin

2012-12-01

287

Primary Localization and Tumor Thickness as Prognostic Factors of Survival in Patients with Mucosal Melanoma  

PubMed Central

Background Data on survival with mucosal melanoma and on prognostic factors of are scarce. It is still unclear if the disease course allows for mucosal melanoma to be treated as primary cutaneous melanoma or if differences in overall survival patterns require adapted therapeutic approaches. Furthermore, this investigation is the first to present 10-year survival rates for mucosal melanomas of different anatomical localizations. Methodology 116 cases from Sep 10 1984 until Feb 15 2011 retrieved from the Comprehensive Cancer Center and of the Central Register of the German Dermatologic Society databases in Tübingen were included in our analysis. We recorded anatomical location and tumor thickness, and estimated overall survival at 2, 5 and 10 years and the mean overall survival time. Survival times were analyzed with the Kaplan-Meier method. The log-rank test was used to compare survival times by localizations and by T-stages. Principal Findings We found a median overall survival time of 80.9 months, with an overall 2-year survival of 71.7%, 5-year survival of 55.8% and 10-year survival of 38.3%. The 10-year survival rates for patients with T1, T2, T3 or T4 stage tumors were 100.0%, 77.9%, 66.3% and 10.6% respectively. 10-year survival of patients with melanomas of the vulva was 64.5% in comparison to 22.3% of patients with non-vulva mucosal melanomas. Conclusion Survival times differed significantly between patients with melanomas of the vulva compared to the rest (p?=?0.0006). It also depends on T-stage at the time of diagnosis (p<0.0001). PMID:25383553

Mehra, Tarun; Grözinger, Gerd; Mann, Steven; Guenova, Emmanuella; Moos, Rudolf; Röcken, Martin; Claussen, Claus Detlef; Dummer, Reinhard; Clasen, Stephan

2014-01-01

288

Cryotherapy for massive vulvar lymphatic leakage complicated with lymphangiomas following gynecological cancer treatment.  

PubMed

Vulvar lymphatic leakage is a severe complication associated with gynecological cancer treatments. However, standard treatment strategies have not yet been determined. We encountered a rare case of a 76-year-old multiparous woman suffering from massive lymphatic fluid leakage from the entire vulva, and papules developed and were identified as lymphangiomas. A large amount of straw-colored discharge continued from all vulvar papules, which extended over the mons pubis. Nine years ago, the patient had undergone a radical hysterectomy with concurrent chemoradiation for uterine cervical cancer treatment. Her serum albumin level was 1.9 mg/dl, which was attributed to the loss of a large amount of lymph fluid due to leakage from the vulva. Her quality of life gradually decreased because of general fatigue and the need for frequent diaper exchanges every 2 h. The patient received a less-invasive treatment with cryotherapy using liquid nitrogen. She also received a multimodality treatment consisting of the intravenous administration of albumin, massage of the lower limbs and intensive rehabilitation. Cryotherapy was administered once a week for 3 months. Her discharge almost stopped and vulvar lymphangiomas decreased without any major complications. To the best of our knowledge, this is the first case report of massive lymphatic leakage complicated with vulvar lymphangiomas. Additionally, this case may represent the first successful treatment of vulva lymph leakage by cryotherapy without recurrence. Cryotherapy may have the potential to improve the quality of life as a less-invasive treatment for gynecological cancer survivors without serious complications. PMID:25190008

Yanazume, Shintaro; Douzono, Haruhiko; Kubo, Hidemichi; Nagata, Tomomi; Douchi, Tsutomu; Kobayashi, Hiroaki

2014-11-01

289

Plasma estrogens and their relationship to uterine infection in the mare  

E-print Network

the palpated follicle was esti- mated to be 3 cm. or greater in diameter or was becomd. ng soft. The mares were then examined at 48 hour intervals snd rebred if ovulation had not occurred. a Deep cervical or intra-uterine cultures were obtained from non... was demonstrated on 2 or more cultures. Each mare considered to be infected was treated with appropriate intra-uterine infusions and the vulva sutured in an effort to prevent continuing infection of the uterus. Treated mares were recultured on the following...

Burns, Stuart James

1974-01-01

290

[Sugar tumor. Rare differential diagnosis of pulmonary clear cell tumor after renal carcinoma].  

PubMed

Pulmonary clear cell or sugar tumor is a rare entity of unknown etiology and histogenesis. As primary extrapulmonal sugar tumor (PEST) this neoplasia can also be found in the trachea, vulva, rectum, pancreas or atrial-septal region. So far about 40 case reports have been published in english literatur. We present the case report of a patient with a pulmonal sugar tumor, who previously underwent nephrectomy because of clear cell renal carcinoma. Clinical aspects, differential diagnosis, therapy and histogenetic aspects are discussed. PMID:14504759

Masur, Y; Becker, H P; Fackeldey, V

2003-09-01

291

Proximal-type epithelioid sarcoma-unusual presentation: unilateral vulvar mass.  

PubMed

Epithelioid sarcoma of the vulva is a very rare malignant soft tissue tumour, usually initially asymptomatic, which simulates a variety of benign lesions, leading to diagnosis only at later stages. Prognosis is generally poor. We report a case of a 55-year-old postmenopausal woman, who presented with rapid growth of an asymptomatic mass located in the left labia majora. Biopsy of the lesion revealed features characteristic of proximal-type epithelioid sarcoma. Ganglionar, adrenal, pulmonary and hepatic metastases were found at thoracoabdominopelvic CT scan. During hospitalisation, the patient's clinical condition suffered rapid deterioration and she died on the 16th day of admission. PMID:25858929

Rodrigues, Ana Isabel; Lopes, Helena Isabel; Lima, Olinda; Marta, Susana

2015-01-01

292

Clinical effect of Kukkutanda Twak Bhasma in the management of Swetapradara  

PubMed Central

Swetapradara is an important gynecological disorder nowadays. Most women in the reproductive age group complain about white discharge. Due to white discharge, they are prone to so many other symptoms, such as backache, itching in vulva, and burning micturition. According to Ayurveda, swetapradara is caused by the vitiation of Kapha and Vata dosha. Kukkutanda twak is also said to be Kapha Vata shamaka and swetapradara shamaka. In Ayurveda so many drugs are mentioned in the treatment of swetapradara. Among them Kukkutanda twak bhasma is a good medicine. In this clinical study Kukkutanda twak bhasma has shown statistically significant improvement in white discharge, backache, itching, anemia, weakness, and urinary tract infection. PMID:22529653

Panda, Gatikrushna; Mohapatra, K. B.

2011-01-01

293

Disseminated transmissible venereal tumour associated with Leishmaniasis in a dog.  

PubMed

This report addresses an atypical transmissible venereal tumour in an 8-year-old bitch that was pluriparous and seropositive for leishmaniasis. There were ascites and a serosanguineous discharge from the vulva, but no lesions on the external genital mucosa. An aspirate of the peritoneal fluid showed mononuclear round cells characteristic of transmissible venereal tumour (TVT). Exploratory laparotomy revealed light red, granulomatous structures in the peritoneum, omentum, spleen, liver and uterine horns. Cytological and histopathological tests confirmed the diagnosis of intra-abdominal TVT. Dissemination of the TVT to several organs inside the abdominal cavity probably resulted from immunosuppression caused by leishmaniasis, which favoured the presence and aggressiveness of TVT. PMID:23279537

Trevizan, J T; Carreira, J T; Souza, N C; Carvalho, I R; Gomes, P B C; Lima, V M F; Orlandi, C M B; Rozza, D B; Koivisto, M B

2012-12-01

294

Description of a new Pratylenchus species from China (Tylenchida, Pratylenchidae).  

PubMed

Pratylenchus ekrami from maize (Zea mays) roots in Shenyang and luffa (Luffa cylindrica) roots in Dalian, China, are described in this paper. Nematodes from the two areas were identified consistently, and were characterized by a heavy cephalic sclerotization, extending posteriorly up to two body annuli, stylet 11-13 ?m long, elongating conoid tail, and becoming thinner from vulva. Males were not found. Pratylenchus ekrami is close to Pratylenchus vulnus, but the most critical characteristics between the two species were the number of lip annuli, stylet size, and shape of stylet knobs. This species is the first reported in China. PMID:24115672

Liu, Ning; Zhou, Xiao-Song; Chen, Li-Jie; Duan, Yu-Xi

2013-10-01

295

Hysteroscopy and episiotomy in a rescued, cold-stressed Florida manatee (Trichechus manatus latirostris) for diagnosis and treatment of a retained fetal skeleton.  

PubMed

A rescued female manatee was observed expelling a fetal bone from the vulva. The manatee was anesthetized and diagnosed with uterine retention of a fetal skeleton by ultrasound and hysteroscopy. Episiotomy was performed to gain manual access to the vagina and uterus for removal of the skeleton. Second intention healing of the episiotomy site produced excellent results. Rescued female manatees should receive a thorough reproductive tract evaluation since presence of retained fetal tissues might not be evident in blood or hormone analyses. Retention of a whole or partial dead fetus can be life-threatening to manatees, and retained tissues should be removed as early as possible. PMID:23082540

Hall, Natalie H; Walsh, Mike; DeLuca, Catherine; Bukoski, Alex

2012-09-01

296

Aggressive angiomyxoma with perineal herniation.  

PubMed

Aggressive angiomyxoma is a rare mesenchymal tumor involving the pelvic-perineal region. It occurs during the third and fourth decade of life and is predominantly seen in females. It presents clinically as a soft tissue mass in variable locations such as vulva, perianal region, buttock, or pelvis. Assessment of extent of the tumor by radiological evaluation is crucial for surgical planning; however, biopsy is essential to establish diagnosis. We present the radiological and pathological features seen in a 43-year-old female diagnosed with abdominal angiomyxoma with an unusual extension to the perineum. PMID:24987570

Narang, Seema; Kohli, Supreethi; Kumar, Vinod; Chandoke, Raj

2014-01-01

297

Aggressive Angiomyxoma with Perineal Herniation  

PubMed Central

Aggressive angiomyxoma is a rare mesenchymal tumor involving the pelvic-perineal region. It occurs during the third and fourth decade of life and is predominantly seen in females. It presents clinically as a soft tissue mass in variable locations such as vulva, perianal region, buttock, or pelvis. Assessment of extent of the tumor by radiological evaluation is crucial for surgical planning; however, biopsy is essential to establish diagnosis. We present the radiological and pathological features seen in a 43-year-old female diagnosed with abdominal angiomyxoma with an unusual extension to the perineum. PMID:24987570

Narang, Seema; Kohli, Supreethi; Kumar, Vinod; Chandoke, Raj

2014-01-01

298

Cellular angiofibroma of oral mucosa: report of two cases.  

PubMed

Cellular angiofibroma is a benign vascular neoplasm that typically arises in the vulva, perineal, and paratesticular region. Microscopically the lesions exhibit multiple small, non-dilated capillary channels, many of which contain erythrocytes. The endothelial lining cells are prominent, with monomorphic oval nuclei. Interposed among the vessels are both delicate and mature collagen fibers with fibroblastic hypercellularity that is variable in older lesions where sclerosis is prominent. The lesions usually do not recur following simple excision. Recent evidence indicates that cellular angiofibromas may be cytogenetically related to spindle cell lipoma. This represents the first reported instances of cellular angiofibroma in the oral cavity. PMID:19644547

Eversole, Lewis R

2009-06-01

299

Extra Mammary Paget's Disease: A Rare Case Report  

PubMed Central

Extramammary Paget's disease is a marginated plaque resembling Paget's disease but occurring in anogenital area, axilla or most commonly on the vulva. A 62-year-old postmenopausal woman presented with extremely pruritic plaque on the perineal skin which progressed gradually over 3 years and did not respond to any topical/systemic steroids, antibiotics, and antifungals. Examination revealed 7 × 8 cm. hypertrophic, verrucous plaque with erosions, and crusts at places. There was no evidence of visceral malignancy. Biopsy showed Paget's cells which were positive for Periodic Acid Schiff and alcian blue stain. Surgical excision was done considering the premalignant potential. PMID:25657432

Sardesai, Vidyadhar R; Agarwal, Trupti D; Sakhalkar, Sarita P

2015-01-01

300

Vulvar Langerhans cell histiocytosis: a case report  

PubMed Central

Langerhans cell histiocytoses (LCH) are a rare group of disorders that comprise a large spectrum of diseases initially known as histiocytosis X. In this case report, we relate a case of LCH affecting the vulva of a 47-year-old female. The patient presented since 3 years with a vulvar lesion characterized by non-healing ulcers and a perineal granuloma on which she underwent surgery. Professionals should keep in mind not to treat straightforwardly lesions of the genital tract as simple sexually transmitted diseases. Chronic, atypical genital lesions seen in women need to be worked up and dealt with accordingly. PMID:25404979

Khoummane, Nadia; Guimeya, Cyriane; Lipombi, Dominique; Gielen, François

2014-01-01

301

Association of several small heat-shock proteins with reproductive tissues in the nematode Caenorhabditis elegans.  

PubMed Central

Immunohistochemical data on 10 of the 14 small heat-shock (smHSPs) proteins in fourth larval stage and adult Caenorhabditis elegans show that the tissues expressing the greatest number of smHSPs are vulva (HSP12s, HSP43 and, under stress, HSP16s) and spermatheca (HSP12s, HSP25, HSP43 and, under stress, HSP16s). HSP43 is also expressed in male tail structures, and following heat-shock HSP16s are expressed in spermatids and spermatozoa. PMID:11001875

Ding, L; Candido , E P

2000-01-01

302

Ultrastructural observations on the surface of Thelazia lacrymalis (Nematoda: Spirurida, Thelaziidae).  

PubMed

Scanning electron microscopy (SEM) was used to study the surface ultrastructure of female Thelazia lacrymalis obtained from naturally infected cattle. At the anterior end, the buccal capsule was cup shaped. The mouth was without lips and was surrounded by four cephalic papillae and two amphids. There were two lateral cervical papillae. Also, a single small papilla was seen on the ventral side, close to the vulvar opening. The vulva was located posterior to the end of the oesophagus and the tail carried an anal pore and a pair of phasmids near the tip. The cuticle was transversally annulated with fine striations. PMID:15959978

Naem, Soraya

2005-01-01

303

Further description of Cruzia tentaculata (Rudolphi, 1819) Travassos, 1917 (Nematoda: Cruzidae) by light and scanning electron microscopy.  

PubMed

Species of Cruzia are parasites of the large intestine of marsupials, reptiles, amphibians, and mammalians. Cruzia tentaculata specimens were collected from the large intestine of Didelphis marsupialis (Mammalia: Didelphidae) from Colombia (new geographical record) and from Brazil and analyzed by light and scanning electron microscopy. The morphology of males and females by light microscopy corroborated most of the previous description and the ultrastructure by scanning electron microscopy evidence: the topography of the cuticle, deirids, amphids, phasmids in both sexes, a pair of papillae near the vulva opening, and the number and location of male caudal papillae, adding new features for species identification only observed by this technique. PMID:19130086

Adnet, F A O; Anjos, D H S; Menezes-Oliveira, A; Lanfredi, R M

2009-04-01

304

Extra Mammary Paget's Disease: A Rare Case Report.  

PubMed

Extramammary Paget's disease is a marginated plaque resembling Paget's disease but occurring in anogenital area, axilla or most commonly on the vulva. A 62-year-old postmenopausal woman presented with extremely pruritic plaque on the perineal skin which progressed gradually over 3 years and did not respond to any topical/systemic steroids, antibiotics, and antifungals. Examination revealed 7 × 8 cm. hypertrophic, verrucous plaque with erosions, and crusts at places. There was no evidence of visceral malignancy. Biopsy showed Paget's cells which were positive for Periodic Acid Schiff and alcian blue stain. Surgical excision was done considering the premalignant potential. PMID:25657432

Sardesai, Vidyadhar R; Agarwal, Trupti D; Sakhalkar, Sarita P

2015-01-01

305

Acute Spontaneous Spinal Subdural Hematoma with Vague Symptoms  

PubMed Central

Spinal subdural hematoma is a rarely reported disease and spontaneous spinal subdural hematomas (SSDH) without underlying pathological changes are even rarer. The patients usually show typical symtoms such as back pain, quadriplegia, paraplegia or sensory change. But rarely, patients may show atypical symptoms such as hemiparesis and misdiagnosed to cerebrovascular accident. We recently experienced a case of SSDH, where the patient initially showed vague symptoms, such as the sudden onset of headache which we initially misdiagnosed as subarachnoid hemorrhage. In this case, the headache of patient improved but the neck pain persisted until hospital day 5. Therefre, we conducted the MRI of cervical spine and finally confirmed SSDH. The patient was managed conservatively and improved without recurrence. In this case report, we discuss the clinical features of SSDH with emphasis on the importance of an early diagnosis. PMID:25368774

Chung, Jaehwan; Hwang, Soo-Hyun; Han, Jong-Woo

2014-01-01

306

Symphysis Pubis Osteomyelitis with Bilateral Adductor Muscles Abscess  

PubMed Central

Osteomyelitis of the pubis symphysis is a rare condition. There have been various reports in the literature of inflammation and osteomyelitis as well as septic arthritis of pubic symphysis. However, due to the fact that these conditions are rare and that the usual presenting symptoms are very nonspecific, osteomyelitis of the pubic symphysis is often misdiagnosed, thus delaying definitive treatment. We present a case that to our knowledge is the first case in literature of osteomyelitis of the pubic symphysis in a 17-year-old boy with juvenile idiopathic arthritis (JIA), which was initially misdiagnosed and progressed to bilateral adductor abscesses. A high suspicion of such condition should be considered in a JIA patient who presents with symphysis or thigh pain. PMID:25580335

Alqahtani, Saad M.; Gdalevitch, Marie

2014-01-01

307

Isolated tubal torsion in the third trimester of pregnancy: A case report and review of the literature  

PubMed Central

Isolated torsion of a fallopian tube in the third trimester of pregnancy is an uncommon event. Its common symptoms are lower abdominal pain, vomiting, and nausea. Because these symptoms are nonspecific, isolated torsion of a fallopian tube may be misdiagnosed, delaying treatment and the opportunity to preserve the tube. This is a case report of a primipara in her third trimester, whowas misdiagnosed as having acute appendicitis and ovarian cyst torsion. The ultrasound-assisted examination was useful, but the specific diagnosis was made after laparotomy and histopathology. The patient was managed by simultaneous salpingectomy and cesarean section. This surgical intervention prevented adverse obstetric sequelae. We summarize our experience, provide our conclusions, and review 17 relevant studies from the literature to aid clinicians in understanding, diagnosing, and managing this condition in a timely fashion. PMID:25657760

Sun, Yan; Liu, Ling-ling; Di, Jian-min

2014-01-01

308

New thoughts on sinus headache.  

PubMed

Sinus headache is not a recognized entity by allergy, otolaryngology, or neurological organizations. Headache is a minor feature in the diagnosis of acute rhinosinusitis and is not validated as a symptom in chronic sinusitis. Sinus headaches are self-diagnosed due to weather triggers, bilateral and frontomaxillary location, and the presence of vasomotor signs and symptoms, all of which can accompany the migraine. Over 90% of self-diagnosed and doctor-diagnosed sinus headaches meet the International Headache Society criteria for migraines, and those migraines misdiagnosed as sinus headaches respond to sumatriptan better than placebo because migraines respond to triptans. Sinus headaches are usually severely disabling migraines, misdiagnosed and mistreated, with 61% of patients receiving antibiotic prescriptions for noninfectious causes, thus failing the patients and, in addition, contributing to a serious public health problem. PMID:15176492

Tepper, Stewart J

2004-01-01

309

Diagnosing the bladder as the source of pelvic pain: successful treatment for adults and children.  

PubMed

The key to successful therapy of interstitial cystitis (IC) is to correctly diagnose it. The significant majority of patients with IC have a dysfunctional bladder epithelium that allows urinary solutes (primarily potassium) to leak into the bladder wall, causing symptoms and tissue damage. Drugs that correct this dysfunction and suppress symptoms are important to achieve successful outcomes in patients. Today over 95% of females with IC are misdiagnosed as having gynecologic chronic pelvic pain, vulvodynia, vaginitis, endometriosis, overactive bladder or urinary tract infection. Men are misdiagnosed as having prostatitis. Often children are not diagnosed at all. Multimodal drug therapy may be required and can achieve successful resolution of IC in over 90% of patients. IC in children can be treated successfully with pentosan polysulfate. PMID:25300387

Parsons, C Lowell

2014-07-01

310

Diagnosis and Conservative Treatment of Extraoral Submental Sinus Tract of Endodontic Origin: A Case Report  

PubMed Central

Sinus tracts (or fistulas) are a common manifestation of pulpal necrosis that requires conventional -or rarely surgical- endodontic treatment in order to heal. They are mainly identified intraorally and in rare cases they manifestate extraorally, depending on the causative tooth, root location, bone thickness and muscle inserts. Such conditions may be misdiagnosed and confused with other non-pulpal pathologies. A case of extra-oral submental sinus tract that was initially misdiagnosed by a physician as a non-odontogenic lesion is presented. Facial fistulas of endodontic origin, despite sparse, should be considered as an option in the differential diagnosis procedure. It is important that interaction occurs between physicians and dentists to avoid exposing patients to insufficient treatment schemes. PMID:25478461

Farmakis, Eleftherios-Terry R

2014-01-01

311

Dental infection simulating skin lesion.  

PubMed

Orocutaneous fistulas or cutaneous sinus, a tract of dental origin, is an uncommon but well-documented condition that usually requires emergency treatment. Such condition may be misdiagnosed by physicians and dentists and may sometimes be confused with bone and skin tumor, osteomyelitis, congenital fistula, salivary gland fistula, pyogenic granuloma, infected cyst, deep mycotic infection, and other pathologies. A case of facial sinus tract that was initially misdiagnosed by a physician as a nonodontogenic lesion is presented. Nonsurgical endodontic therapy was the treatment of choice for this case. Facial cutaneous sinus tracts must be considered of dental origin. Early diagnosis and prompt treatment minimize patient discomfort and esthetic problems, reducing the possibility of further complications such as sepsis and osteomyelitis. PMID:22892779

Abuabara, Allan; Schramm, Celso Alfredo; Zielak, Joăo César; Baratto-Filho, Flares

2012-01-01

312

Acute spontaneous spinal subdural hematoma with vague symptoms.  

PubMed

Spinal subdural hematoma is a rarely reported disease and spontaneous spinal subdural hematomas (SSDH) without underlying pathological changes are even rarer. The patients usually show typical symtoms such as back pain, quadriplegia, paraplegia or sensory change. But rarely, patients may show atypical symptoms such as hemiparesis and misdiagnosed to cerebrovascular accident. We recently experienced a case of SSDH, where the patient initially showed vague symptoms, such as the sudden onset of headache which we initially misdiagnosed as subarachnoid hemorrhage. In this case, the headache of patient improved but the neck pain persisted until hospital day 5. Therefre, we conducted the MRI of cervical spine and finally confirmed SSDH. The patient was managed conservatively and improved without recurrence. In this case report, we discuss the clinical features of SSDH with emphasis on the importance of an early diagnosis. PMID:25368774

Chung, Jaehwan; Park, In Sung; Hwang, Soo-Hyun; Han, Jong-Woo

2014-09-01

313

Delivery Induced Intraperitoneal Rupture of a Cystic Ovarian Teratoma and Associated Chronic Chemical Peritonitis  

PubMed Central

Intraperitoneal rupture of cystic ovarian teratoma is a rare complication. We report a case in a 29-year-old female, with increased abdominal circumference 2 months after vaginal delivery. MRI/CT raised this diagnosis associated to chemical peritonitis. A malignant ovarian mass with peritoneal carcinomatosis was excluded. Laparoscopic oophorectomy was performed and histologic analysis confirmed imaging findings. This case demonstrates the interest of imaging before surgery in pelvic masses to avoid misdiagnosing and to provide adequate treatment. PMID:24744942

Nader, Reine; Thubert, Thibault; Deffieux, Xavier; de Laveaucoupet, Jocelyne; Ssi-Yan-Kai, Guillaume

2014-01-01

314

Surgical treatment of thoracic outlet syndrome in young adults: single centre experience with minimum three-year follow-up  

Microsoft Academic Search

Thoracic outlet syndrome is an often misdiagnosed syndrome which consists of a neurovascular compression at the upper thoracic\\u000a outlet. The clinical presentation can be variable, ranging from mild symptoms to venous thrombosis and muscle atrophy. Many\\u000a aetiologies, both congenital and acquired, related either to bony or soft tissue anomalies, have been associated with this\\u000a syndrome. As a consequence, the diagnosis

Pietro Ciampi; Celeste Scotti; Simonetta Gerevini; Francesco De Cobelli; Roberto Chiesa; Gianfranco Fraschini; Giuseppe M. Peretti

315

Depression, quality of life and breast cancer: a review of the literature  

Microsoft Academic Search

Depression is misdiagnosed and undertreated among breast cancer population. Risk factors for depression in the 5 years after\\u000a diagnosis are related more to the patient rather than to the disease or its treatment. The breast cancer stage (early and\\u000a advanced) is not statistically significant in terms of rates of psychosocial distress except for recurrence. Risk factors\\u000a of depression might impair quality

M. Reich; A. Lesur; C. Perdrizet-Chevallier

2008-01-01

316

Asymptomatic enlargement of the clavicle: a review of underlying aetiologies.  

PubMed

An asymptomatic enlargement of the medial clavicle is a condition that is often both missed and misdiagnosed. We review the most common causes of an isolated and asymptomatic enlargement of the medial clavicle. Underlying aetiologies include osteoarthritis of the sternoclavicular joint, condensing osteitis, spontaneous dislocation of the sternoclavicular joint, and sternocostoclavicular hyperostosis. Key points in the history and physical examination as well as characteristic radiographic findings are sufficient for correct diagnoses. Treatment is conservative. PMID:21302566

Petrov, Dmitriy; Marchalik, Daniel; Lipsky, Andrew; Milgraum, Sandy

2010-12-01

317

KU Today, January 28, 2013  

E-print Network

KU Today Campus Newsletter | Problems viewing this e-mail? View online. Monday, January 28, 2013 A case for milk and cookie disease Dr. Julie Wei with KU Medical Center has spent years treating children with ear, nose and throat... complaints. After developing a theory that her patients' diets, particularly dairy and sugar, might be a major factor in their symptoms, she published her findings in a new book, "A Healthier Wei: Reclaiming Health for Misdiagnosed and Overmedicated...

318

Persistent ankle pain following a sprain: a review of imaging  

Microsoft Academic Search

The initial diagnosis of an “ankle sprain” is not always correct. Prolonged pain, swelling and disability sufficient to limit\\u000a the activity and refractory to treatment following an ankle injury are not typical of an ankle sprain and should alert the\\u000a clinician of the possibility of an alternative or an associated diagnosis. There are several conditions that can be misdiagnosed\\u000a as

Ramy Mansour; Zaid Jibri; Sridhar Kamath; Kausik Mukherjee; Simon Ostlere

2011-01-01

319

Lime-induced phytophotodermatitis.  

PubMed

This case describes a scenario of lime-induced phytophotodermatitis. Phytophotodermatitis is a dermatitis caused after the skin is exposed to photosensitizing compounds in plants and then exposed to sunlight. Many common plants including citrus fruits, celery, and wild parsnip contain these photosensitizing compounds which cause phytophotodermatitis. It is important for a physician to be aware of phytophotodermatitis because it may often be misdiagnosed as other skin conditions including fungal infection, cellulitis, allergic contact dermatitis, and even child abuse. PMID:25317269

Hankinson, Andrew; Lloyd, Benjamin; Alweis, Richard

2014-01-01

320

Three Different Dermoscopic View of Three New Cases with Pilomatrixoma  

PubMed Central

Pilomatrixoma is a benign soft tissue neoplasm originated from follicular matrix of hair and is also known as Malherbe's calcified epithelioma. Some lesions are located on the skin and are usually misdiagnosed. A small number of patients had been dermoscopically examined. In this article, three patients of pilomatrixoma who had three different dermoscopic views were evaluated and discussed in concordance with the literature. PMID:25114449

Ayhan, Erhan; Ertugay, OC; Gundogdu, R

2014-01-01

321

Reversible metastatic pulmonary calcification in a patient with multiple myeloma  

Microsoft Academic Search

A-52-year-old patient presented with a 2-year history of multiple myeloma, recurrent episodes of hypercalcemia, and extensive\\u000a bone involvement. She developed pulmonary infiltrates, initially misdiagnosed as interstitial pneumonia. High-resolution computed\\u000a tomography and bone scintiscanning indicated pulmonary calcification, which was confirmed by a transbronchial biopsy. Cytostatic\\u000a treatment of multiple myeloma in combination with repetitive i.v. administration of bis-phosphonates over a period of

C. K. Weber; J. M. Friedrich; E. Merkle; O. Prümmer; A. Hoffmeister; T. Mattfeldt; N. Frickhofen

1996-01-01

322

Management of a parturient with an anterior sacral meningocele.  

PubMed

Anterior sacral meningoceles are rare disorders featuring anterior herniation of the meninges through a sacral defect or foramen. They are frequently misdiagnosed as ovarian or abdominal cysts and surgical exploration has resulted in meningitis. In pregnancy it represents an obstacle to delivery of the fetus and rupture of the meningocele during vaginal delivery is a significant risk. The successful multidisciplinary management of a primiparous patient with an anterior sacral meningocele and previous abdominal surgery is presented. PMID:23122279

McGregor, C; Katz, S; Harpham, M

2013-01-01

323

Lime-induced phytophotodermatitis  

PubMed Central

This case describes a scenario of lime-induced phytophotodermatitis. Phytophotodermatitis is a dermatitis caused after the skin is exposed to photosensitizing compounds in plants and then exposed to sunlight. Many common plants including citrus fruits, celery, and wild parsnip contain these photosensitizing compounds which cause phytophotodermatitis. It is important for a physician to be aware of phytophotodermatitis because it may often be misdiagnosed as other skin conditions including fungal infection, cellulitis, allergic contact dermatitis, and even child abuse. PMID:25317269

Hankinson, Andrew; Lloyd, Benjamin; Alweis, Richard

2014-01-01

324

Mucopolysaccharidosis type III (Sanfilippo syndrome) and misdiagnosis of idiopathic developmental delay, attention deficit/hyperactivity disorder or autism spectrum disorder  

PubMed Central

Mucopolysaccharidosis III is a rare genetic disease characterized by progressive cognitive decline and severe hyperactivity that does not respond to stimulants. Somatic features are relatively mild. Patients are often initially misdiagnosed as having idiopathic developmental delay, attention deficit/hyperactivity disorder and/or autism spectrum disorders, putting them at risk for unnecessary testing and treatments. Conclusion: Children with developmental or speech delay, especially those with a characteristic somatic feature or behavioural abnormalities, should be screened for MPS III. PMID:23336697

Wijburg, Frits A; W?grzyn, Grzegorz; Burton, Barbara K; Tylki-Szyma?ska, Anna

2013-01-01

325

Psoriasis first presenting around an enteral feeding tube in three pediatric patients: an important consideration for timely diagnosis and management.  

PubMed

Pediatric dermatologists may care for patients with percutaneous enteral feeding tubes. Although ostomy complications such as allergic contact and irritant dermatitis are common, psoriasis may be misdiagnosed. We report three novel cases of childhood psoriasis first presenting around an enteral feeding tube site. Localized psoriasis is an important clinical consideration in children with ostomy site eruptions to ensure timely diagnosis and effective management. PMID:23937450

Zitelli, Kristine B; Lucky, Anne W

2014-01-01

326

Pinning Down Coronal Heating Properties in the Presence of Non-Equilibrium Ionization  

NASA Astrophysics Data System (ADS)

We examine the effects that non-equilibrium ionization can have on the evolution of light curves emitted by transition region and coronal ions during impulsive heating, and how this can lead to the plasma and heating properties being misdiagnosed. Furthermore, through detailed numerical and forward modeling we demonstrate how the effects of non-equilibrium ionization can be mitigated and accounted for so that robust diagnostics can be developed.

Bradshaw, Stephen; Testa, Paola

2015-04-01

327

Experimental induction of panic-like symptoms in patients with postural tachycardia syndrome  

Microsoft Academic Search

Patients with postural tachycardia syndrome (POTS) might be misdiagnosed with panic disorder due to shared clinical features.\\u000a The first aim of our study was to investigate the relationship between symptoms of POTS and panic disorder. The second aim\\u000a was to delineate clinical features distinguishing symptoms of POTS from panic disorder. A total of 11 patients with POTS and\\u000a 11 control

Ramesh K. Khurana

2006-01-01

328

Varicella outbreak in a daycare: challenges and opportunities for preventing varicella outbreaks in this setting.  

PubMed

As a result of single-dose varicella vaccination, daycare outbreaks have become rare. We investigated a daycare outbreak resulting from a misdiagnosed varicella case in an unvaccinated attendee. Of 25 attendees aged 12-32 months without evidence of immunity, 7 (28%) were unvaccinated due to religious/philosophical opposition or recent 1st birthday. Single-dose vaccination reduced disease by 92% compared with no vaccination. PMID:24136372

Daskalaki, Irini; Thermitus, Rodrerica; Perella, Dana; Viner, Kendra; Spells, Niya; Mohanty, Salini; Lopez, Adriana; Johnson, Caroline

2014-04-01

329

Ejaculatory disorders: pathophysiology and management  

Microsoft Academic Search

Ejaculatory dysfunction (EjD) is one of the most common male sexual disorders, yet EjD is still frequently misdiagnosed or overlooked as a result of numerous patient and physician barriers. The wide spectrum of EjD ranges from premature or rapid ejaculation, through delayed ejaculation, to a complete inability to ejaculate—otherwise known as anejaculation—and includes retrograde ejaculation and painful ejaculation. Conventional algorithms

Carlo Bettocchi; Paolo Verze; Fabrizio Palumbo; Davide Arcaniolo; Vincenzo Mirone

2008-01-01

330

Photodynamic therapy as an adjunct to systemic treatment in a case with unilateral presumed vascularized choroidal tuberculous granuloma  

Microsoft Academic Search

Intraocular tuberculosis cannot be diagnosed easily in some clinical circumstances. A 29-year-old otherwise healthy woman\\u000a who was initially misdiagnosed and treated empirically with systemic steroids and sulfamethoxazole–trimethoprim for toxoplasmosis\\u000a was referred to us for severe visual loss. We instituted quadruple antituberculosis treatment upon chest medicine consultation\\u000a as all attempts, including consecutive intravitreal antibiotic injections, could not prevent the enlargement of

Ali Osman Saatci; Ozlem Barut Selver; Aylin Yaman; Gul Arikan; Arzu Sayiner; Atilla Akkoclu

2009-01-01

331

The natural history of primary temporal bone myxoma.  

PubMed

Primary myxomas of the temporal bone are rare tumors. If misdiagnosed, they can grow into locally aggressive expansile masses resulting in hearing loss, facial paralysis, dural invasion, and mass effect on the adjacent brain parenchyma. This case demonstrates the natural history of an extraordinarily rare tumor over a longer period not previously described. The importance of correlating histopathologic findings with diagnostic imaging features to enable an accurate diagnosis is also emphasized. PMID:22483549

Guha-Thakurta, Nandita; Deavers, Michael; DeMonte, Franco; Gidley, Paul W

2012-08-01

332

Cutaneous Lymphadenoma: A Rare Case and Brief Review of a Diagnostic Pitfall  

PubMed Central

We report a case of cutaneous lymphadenoma on the posterior left ear of a 67-year-old woman. Although it is benign, recognition of cutaneous lymphadenoma is important as it presents a diagnostic pitfall to the unsuspecting dermatologist and general surgical pathologist, who may readily misdiagnose the lesion because it is not only very rare, but also clinically and histologically resembles the far more common and locally destructive basal cell carcinoma. PMID:25002949

Yu, Ryan; Salama, Samih; Alowami, Salem

2014-01-01

333

Comparison of host-, herd-, and environmental-factors associated with serpositivity to neospora caninum among adult beef and dairy cattle in alberta  

E-print Network

factors (Haddad et al., 2005). In previous studies, conclusions concerning risk factors for NC among beef and dairy cattle were drawn from vastly different study designs, making comparisons between studies, and particularly the two herd types..., neosporosis, which may affect a variety of species including canine, bovine, and a wide variety of wildlife. Prior to 1988, infections with NC were often misdiagnosed as toxoplasmosis in dogs, which is caused by Toxoplasma gondii (Dubey et al., 1988...

Dietz, Mark Colton

2009-05-15

334

Managing the Unexpected: Complexity as Distributed Sensemaking  

NASA Astrophysics Data System (ADS)

In 1998 the Centers for Disease Control (CDC) published a statement of their strategy entitled "Preventing Emerging Infectious Diseases: A Strategy for the 21st Century." They described their central challenge this way: "because we do not know what new diseases will arise, we must always be prepared for the unexpected" (p. vii). Soon after they published that statement CDC was confronted with an unexpected emerging disease, the West Nile Virus, which they misdiagnosed initially.

Weick, Karl E.

335

Unicystic Ameloblastoma Masquerading as Huge Periapical Lesion, both Clinically and Histopathologically: Two Case Reports with Review of Literature  

PubMed Central

Unicystic ameloblastoma (UA) is one of the variants of ameloblastoma. It manifests as unilocular radiolucency in the mandible or maxilla on X-ray scans. In very rare cases, it can appear as a localized periradicular radiolucent area, imitating a periapical lesion. In this article, we present two cases of UA that were initially misdiagnosed as periapical lesions. Subsequently, surgical enucleation was performed and the diagnosis of UA was confirmed histopathologically. PMID:24516772

Satyabhusan, N. V. V.; Routray, Samapika; Bendi, Lavanya; Suresh, B Venkat; Majumdar, Sumit; Mohanty, Neeta

2013-01-01

336

IgG marker of optic-spinal multiple sclerosis binds to the aquaporin-4 water channel  

Microsoft Academic Search

Neuromyelitis optica (NMO) is an inflammatory demyelinating disease that selectively affects optic nerves and spinal cord. It is considered a severe variant of multiple sclerosis (MS), and frequently is misdiagnosed as MS, but prognosis and optimal treatments differ. A serum immunoglobulin G autoantibody (NMO-IgG) serves as a specific marker for NMO. Here we show that NMO-IgG binds selectively to the

Vanda A. Lennon; Thomas J. Kryzer; Sean J. Pittock; A. S. Verkman; Shannon R. Hinson

2005-01-01

337

Osteosarcoma of the talus: a case report.  

PubMed

The reported incidence of osteosarcoma of the foot is very low. Osteosarcoma of the talus is extremely rare and few cases have been reported in the literature. The clinical findings are not typical, and osteosarcoma of the talus can be easily misdiagnosed, resulting in a delay in proper treatment. We report the case of a patient with osteosarcoma of the talus, from a series of 120 osteosarcomas treated at our hospital between 1966 and 2002. PMID:16570907

Seijas, Roberto; Minguell, Joan; Pérez, Manuel

2006-01-01

338

Acute focal bacterial nephritis in 25 children  

Microsoft Academic Search

Acute focal bacterial nephritis (AFBN), formerly known as lobar nephronia, is a rare form of interstitial bacterial nephritis.\\u000a Most often described in adults with diabetes, there is only limited knowledge of AFBN in children. Ultrasound shows circular\\u000a hypoechogenic, hypoperfused parenchyma lesions, which may be misdiagnosed as a renal abscess or tumor. From 1984 to 2005,\\u000a AFBN was diagnosed in 30

Tanja Seidel; Eberhard Kuwertz-Bröking; Sigrid Kaczmarek; Martin Kirschstein; Michael Frosch; Monika Bulla; Erik Harms

2007-01-01

339

Congenital midureteral obstruction  

Microsoft Academic Search

Congenital midureteral obstruction, caused either by a ureteral valve or stricture, is an exceedingly rare entity. When encountered,\\u000a it is generally misdiagnosed as either primary megaureter or ureteropelvic junction obstruction, leading to a less than optimal\\u000a surgical approach. Seven children with midureteral obstruction were seen over the past 17 years. Two of the patients presented\\u000a with hydronephrosis on prenatal ultrasonography,

Steven G. Docimo; Robert L. Lebowitz; Alan B. Retik; Arnold H. Colodny; Stuart B. Bauer; James Mandell

1989-01-01

340

Congenital ureteric strictures: an uncommon cause of antenatally detected hydronephrosis  

Microsoft Academic Search

Often misdiagnosed as primary megaureter or pelviureteric junction obstruction, congenital ureteral stenosis and valves are\\u000a the main causes of congenital ureteric obstruction. We report three consecutive cases of congenital ureteric strictures presenting\\u000a with antenatally diagnosed hydronephrosis. Two of our cases had a contralateral multicystic dysplastic kidney. We discuss\\u000a the aetiology, clinical presentation, diagnostic evaluation, surgical management, and operative results as

John A. Cauchi; Harish Chandran

2005-01-01

341

Enduring Fluoride Health Hazard for the Vesuvius Area Population: The Case of AD 79 Herculaneum  

Microsoft Academic Search

BackgroundThe study of ancient skeletal pathologies can be adopted as a key tool in assessing and tracing several diseases from past to present times. Skeletal fluorosis, a chronic metabolic bone and joint disease causing excessive ossification and joint ankylosis, has been only rarely considered in differential diagnoses of palaeopathological lesions. Even today its early stages are misdiagnosed in endemic areas.Methodology\\/Principal

Pierpaolo Petrone; Michele Giordano; Stefano Giustino; Fabio M. Guarino

2011-01-01

342

Cervical external root resorption in vital teeth.  

PubMed

External resorptions associated with inflammation in marginal tissues present a difficult clinical situation. Many times, lesions are misdiagnosed and confused with caries and internal resorptions. As a result inappropriate treatment is often initiated. This paper provides three-dimensional representations of cervical external resorption, based on X-ray microfocus-tomographical scanning of a case, which will aid the dental practitioner in recognizing characteristic features during clinical inspection. In addition, histopathological examination reveals the cellular morphology of the adjacent tissues. PMID:12296786

Bergmans, L; Van Cleynenbreugel, J; Verbeken, E; Wevers, M; Van Meerbeek, B; Lambrechts, P

2002-06-01

343

[Pyomyositis: an infectious complication in systemic lupus erythematous].  

PubMed

Pyomyositis is a primary pyogenic muscular infection. It has been originally described in the tropics. Presenting signs and symptoms are not specific. It is frequently misdiagnosed in the early stages. We report the case of a 47-year-old woman with systemic lupus erythematosus treated with corticosteroids who presented a thigh pyomyositis evidenced by echography and MRI. Outcome was uneventful after antibiotics and surgical drainage. Pyomyositis is increasingly described among immunocompromised people, including lupus patients treated with corticosteroids. PMID:19362395

El Baaj, M; Tabache, F; Modden, K; Hassikou, H; Safi, S; Khalid, R; Hadri, L

2010-03-01

344

Unilocular macrocystic serous cystadenoma of the pancreas--atypical features: a case report.  

PubMed

The authors report and discuss an exceedingly rare case of a unilocular macrocystic serous cystadenomas diagnosed in a 63-year-old female patient, which was preoperatively misdiagnosed as a mucinous cystic neoplasm, due to the atypical magnetic resonance (MR) imaging features shown at presentation and the misleading results obtained through cystic fluid analysis. This manuscript overviews the typical and atypical manifestations of this entity and highlights the advantages, potential limitations and pitfalls of both MR imaging and cystic fluid analysis. PMID:24461471

Leite, Inęs; Palmeiro, Marta; Farchione, Alessandra; Matos, Celso; Bali, Maria Antonieta; Demetter, Pieter; Delhaye, Myriam

2014-01-01

345

Schizoaffective Disorder With Missed Diagnosis of Acute Porphyria: A Case Report and Overview  

PubMed Central

Acute porphyrias are often misdiagnosed and most commonly present as atypical neuropsychiatric symptoms or acute abdominal pain. Clinicians should suspect acute porphyrias in patients presenting with variable neuropsychiatric symptoms and unexplained pain. Proper identification can lead to less iatrogenicity associated with porphyrinogenic agents, appropriate management, and a better patient outcome. The case of a patient with hereditary coproporphyria, one of the acute porphyrias, is presented to illustrate the broad manifestations, unsuspected diagnosis, and difficulties in management. PMID:22454794

Bennett, Jeffrey I.; Resch, David S.; Godwin, John E.

2011-01-01

346

Imaging of the Wrist  

Microsoft Academic Search

\\u000a Imaging of the wrist and hand is a challenging task in the field of musculoskeletal imaging. The anatomy is complex. Knowledge\\u000a of normal anatomic variants, asymptomatic findings, and other diagnostic pitfalls is crucial for accurate analysis. Variants\\u000a and pitfalls are commonly found as coincidental findings and may easily be misdiagnosed as relevant abnormalities. The consequences\\u000a may be over-treatment. Familiarity with

Christian W. A. Pfirrmann

347

A clockwork ear.  

PubMed

Objective tinnitus refers to a tinnitus that can also be heard by the examiner. It is a relatively rare condition, and can be misdiagnosed or neglected. Some causes of objective tinnitus are head and neck vascular malformations, or muscular myoclonus of the tensor tympani, stapedial, or palatal muscles. The case of an 11-year-old girl with an objective tinnitus lasting from 1 year is herein presented, and the diagnostic workup performed in this unusual case is described. PMID:22711231

Alicandri-Ciufelli, M; Soloperto, Davide; Palma, Silvia; Marrara, Antonino; Genovese, Elisabetta

2012-06-01

348

Classic biphasic pulmonary blastoma with brain and axillary metastases: a case report with molecular analysis and review of literature  

PubMed Central

Pulmonary blastoma is a rare series of malignant lung tumor, which contains three categories: classic biphasic pulmonary blastoma, pluropulmonary blastoma, and well-differentiated fetal adenocarcinoma. In this study, a 19-year old female suffering with classic biphasic pulmonary blastoma and metastases in brain and axilla was presented with special interest in clinicopathological presentations, immunohistochemical features, and molecular characterizations. However, this case was misdiagnosed initially with small biopsy specimen. Comprehensive management should be used for the treatment of this malignancy. PMID:25755806

Xiu, Yingjie; Jiang, Lili; Liu, Weiping

2015-01-01

349

An unusual presentation of a dural arteriovenous fistula of the sphenoparietal sinus.  

PubMed

Dural arteriovenous fistulae (DAVFs) are a rare form of intracranial arteriovenous malformation. We present the case of a patient who presented in a previously undescribed manner with facial swelling and bruising initially misdiagnosed as cellulitis. He was found subsequently to have DAVFs of the sphenoparietal sinus that had hemorrhaged. The rarity of DAVFs at this location may account for this unique presentation. Successful treatment was achieved by transarterial embolization. PMID:24646692

Macdonald, Andrew; Plaha, Puneet; Byrne, James

2015-03-01

350

Endovascular treatment of vein of Galen dural arteriovenous fistula presenting as dementia  

PubMed Central

Dural arteriovenous fistula (DAVF) is an important cause of neurological dysfunction that is often misdiagnosed, especially in elderly population. Galenic DAVFs are a subtype of the rare falcotentorial DAVFs with a high risk of hemorrhage and aggressive clinical course. In most cases, DAVFs present with pulsatile tinnitus, headache, or orbital symptoms such as chemosis and proptosis. We report a patient with DAVF of Vein of Galen presented with progressive dementia, treated by Onyx embolisation and had good clinical outcome. PMID:25506172

Huded, Vikram; Moeed, Syed Zafer; Desouza, Romnesh; Tripathi, Ravikesh; Nair, Rithesh

2014-01-01

351

Multiple Aortic Operations in Loeys-Dietz Syndrome: Report of 2 Cases  

PubMed Central

Due to its low prevalence and because there is lack of awareness about it, Loeys-Dietz syndrome is often mis-diagnosed as Marfan syndrome, which has similar skeletal abnormalities and aortic pathology. However, the differential diagnosis between these two connective tissue diseases is critical because they correspond to different surgical indications and surgical decision-making. We report two cases of successful thoracoabdominal aortic replacement in patients with previously undiagnosed Loeys-Dietz syndrome. PMID:25551076

Na, Kwon Joong; Park, Kay-Hyun

2014-01-01

352

A case of calcified ureteritis cystica: an indiscernible condition from ureterolithiasis.  

PubMed

Ureteritis cystica is characterized by formation of multiple cysts in the wall of the renal pelvis or ureter. The clinical course is usually slow, but manifests if the cysts cause infection or obstruction. Stones are further complication to the disease. In this case study, we present a 39-year-old male originally referred with renal colic and misdiagnosed as ureterolithiasis due to the calcifiying cysts. PMID:19655701

Alicioglu, B; Kaplan, M; Aktoz, T; Atakan, I H

2009-01-01

353

Surgical management of peripheral variant of adenomatoid odontogenic tumor: A rare case report with review  

PubMed Central

The adenomatoid odontogenic tumour (AOT) is a relatively uncommon lesion constituting around 3% of all odontogenic tumours and often misdiagnosed as an odontogenic cyst. It manifests as a beningn growth which affects young individuals, with a female predeliction usually in the second decade of life, exhibiting more often in the anterior region of maxilla. The current article enumerates the clinical, radiographic and histopathological features of a rare case of extraosseous AOT with its therapeutic consideration PMID:25684929

Jindwani, Karuna; Paharia, Y. K.; Kushwah, Atul Pratap Singh

2015-01-01

354

Anterior cruciate ligament mucoid degeneration: a review of the literature and management guidelines  

Microsoft Academic Search

Purpose  Anterior cruciate ligament (ACL) mucoid degeneration is a rare encounter in clinical practice, different, but often confused\\u000a with ACL mucoid cysts. Its pathophysiology remains unclear. However, recent publications have suggested that it might be underdiagnosed\\u000a or misdiagnosed, and that the adverse effects of treatment by ACL resection might be underestimated. The object of this work\\u000a was to summarize this scattered

Francois Lintz; Nicolas Pujol; Philippe Boisrenoult; Kevin Bargoin; Philippe Beaufils; David Dejour

2011-01-01

355

Inversion lateral ankle trauma: differential diagnosis, review of the literature, and prospective study.  

PubMed

This study is comprised of 71 patients with inversion injuries. The purpose of this article is to present a logical and orderly approach in evaluating these injuries. A comprehensive review of the literature concerning diagnostic techniques and mechanisms of injury related to inversion ankle trauma is presented. Inversion ankle injuries are frequently misdiagnosed as simple sprains when frequently there are other pathologies present. The standard approach of evaluating inversion ankle injuries is often inadequate. PMID:3584848

Perlman, M; Leveille, D; DeLeonibus, J; Hartman, R; Klein, J; Handelman, R; Schulz, E; Wertheimer, S

1987-01-01

356

Primary autoimmune myelofibrosis in a 36-year old patient presenting with isolated extreme anemia  

PubMed Central

Primary autoimmune myelofibrosis is a very rare condition characterized by peripheral blood cytopenias, bone marrow fibrosis with lymphoid aggregates, and by the finding of autoantibodies in peripheral blood, suggesting a systemic autoimmune process. Patients can be frequently misdiagnosed as having the more common disorder primary myelofibrosis, a myeloproliferative neoplasm. We report the case of a patient with primary autoimmune myelofibrosis with emphasis on the clinical and pathological features that lead to the diagnosis. PMID:19748119

Santos, Fabio P S; Konoplev, Sergej N; Lu, Huifang; Verstovsek, Srdan

2015-01-01

357

Secondary disorders of glycosylation in inborn errors of fructose metabolism  

Microsoft Academic Search

Summary  Adamowicz and colleagues raised the alert in 2007 about patients with atypical hereditary fructose intolerance (HFI) primarily\\u000a misdiagnosed as CDG Ix. We describe a girl with neonatal hypertonia, facial trismus, absent swallowing and coughing reflexes,\\u000a gastro-oesophageal reflux and sporadically elevated Krebs cycle metabolites and lactate. At 14 months microcephaly and hepatomegaly\\u000a were noted, with hypertransaminasaemia but normal blood coagulation, glucose, phosphate,

E. Quintana; L. Sturiale; R. Montero; F. Andrade; C. Fernandez; M. L. Couce; R. Barone; L. Aldamiz-Echevarria; A. Ribes; R. Artuch; P. Briones

358

Solitary Pilar Leiomyoma of the Nasal Dorsum: Case Report and Literature Review  

PubMed Central

Cutaneous leiomyoma is an infrequently occurring benign tumor that arises from smooth muscle in the skin. Pilar leiomyoma, a subtype of cutaneous leiomyoma, arises from the arrector pili muscle associated with hair follicles. Pilar leiomyoma, particularly in the head and neck region, is rare and frequently misdiagnosed. We report one patient who developed pilar leiomyoma of the nasal dorsum, explore the differential diagnosis and review the characteristics of previously reported individuals with pilar leiomyoma of the nasal dorsum. PMID:25657404

Hoyt, Brian S; Tschen, Jaime A; Cohen, Philip R

2015-01-01

359

A Case of Reed's Syndrome: An Underdiagnosed Tumor Disorder  

PubMed Central

Cutaneous leiomyomas are uncommon, benign smooth muscle tumors originating from the arrector pili muscle of the hair follicle that are frequently unrecognized and underdiagnosed by clinicians. They sometimes coexist with common uterine fibroids in an inherited disorder named multiple cutaneous and uterine leiomyomatosis, also referred to as Reed's syndrome. We report a case of Reed's syndrome in a young woman who had been misdiagnosed for many years. PMID:25232316

Kontochristopoulos, Georgios; Kouris, Anargyros; Balamoti, Evgenia; Vavouli, Charitomeni; Markantoni, Vasiliki; Christofidou, Elefteria; Antoniou, Christina

2014-01-01

360

Bilateral vestibular loss.  

PubMed

Bilateral vestibular loss is a rare cause of visual disturbance (oscillopsia) and imbalance. When severe, the most common cause is iatrogenic-gentamicin ototoxicity. Bilateral loss is easily diagnosed at the bedside with the dynamic illegible E test. If this test is omitted, it can easily be misdiagnosed as a cerebellar syndrome. Treatment is largely supportive. Care should be taken to avoid medications that suppress vestibular function, and to encourage activity. PMID:24057822

Hain, Timothy C; Cherchi, Marcello; Yacovino, Dario A

2013-07-01

361

Inborn errors of purine and pyrimidine metabolism  

Microsoft Academic Search

Summary  Genetic disorders of purine and pyrimidine (PP) metabolism are under-reported and infrequently mentioned in the general literature,\\u000a as well as in reviews dedicated to other inborn errors of metabolism. Owing to limited awareness, relatively recent recognition,\\u000a as well as considerable phenotypic variation, these disorders may often be misdiagnosed or remain undiagnosed. Disorders that\\u000a arise as a result of dysfunction in

A. Jurecka

2009-01-01

362

[Malignant priapism as a sign of a recurrent prostate cancer. Differential diagnosis of induratio penis plastica].  

PubMed

A 62-year-old patient was referred with the suspected diagnosis of Peyronie disease. The patient showed the clinical picture of a beginning malignant priapism with hematogenous metastases from an recurrent prostatic carcinoma. The penile metastases were misdiagnosed as Peyronie disease. Although both clinical pictures show some superficial similarity, Peyronie disease usually fulfills classical criteria which help to clearly distinguish it from neoplastic diseases. PMID:12759740

Meineke, V; Köhn, F-M; Pickl, U; Ring, J; Vogt, H-J

2003-06-01

363

Atypical odontalgia--an update.  

PubMed

Atypical odontalgia is a commonly misdiagnosed condition that frequently leads to unnecessary dental treatments such as extraction and endodontic therapy. These treatments often worsen the pain. Despite greater recognition and understanding of this condition, proper diagnosis and treatment remains a challenge. It is believed that atypical odontalgia is a neuropathic condition. This article updates the current understanding of the etiology and pathophysiology of atypical odontalgia, and provides appropriate diagnostic and management approaches for this condition. PMID:23097829

Patel, Seena B; Boros, Audrey L; Kumar, Satish K S

2012-09-01

364

Wrist Tenosynovitis due to Mycobacterium bovis Infection: Case Series and Review of the Literature  

PubMed Central

Summary: Tuberculosis infections are still one of the most important public health problems among developing countries. Musculoskeletal involvement represents 10–15% of all extrapulmonary cases. Tuberculosis tenosynovitis is usually misdiagnosed as nonspecific tenosynovitis. To avoid misdiagnosis and mistreatment, it is important to be alert for mycobacterial infections. This article presents 3 patients with wrist tenosynovitis, which was caused by Mycobacterium bovis infection. The article also includes review of the literature. PMID:25587496

Güner, Mehmet Dervi?; Bekta?, Umut; Akme?e, Ramazan; Armangil, Mehmet; Ay, ?adan

2014-01-01

365

Petrous Apex Cholesterol Granuloma Presenting as Endolymphatic Hydrops: A Case Report  

Microsoft Academic Search

A petrous apex cholesterol granuloma (PACG) is the most common lesion of the petrous apex mass. Affected patients present with various symptoms such as hearing loss, vertigo, headache, tinnitus, facial spasms, and diplopia. We report the case of a 32-yr-old man with a PACG, who was first misdiagnosed with Me@nie$re's disease. He was placed on a low- salt diet, and

Ho Chan Kim; Yun Suk An; Joong Ho Ahn

2009-01-01

366

Caution for diagnosis and surgical treatment of recurrent cholangitis: lessons from 5 cases of bile duct tumor thrombus without a detectable intrahepatic tumor.  

PubMed

The hepatocellular carcinoma (HCC) patients with bile duct tumor thrombus (BDTT) usually have no specific clinical symptoms at early stages. HCC with BDTT was usually misdiagnosed when the intrahepatic tumor was small, even undetectable. In this study, 5 cases of HCC with BDTT misdiagnosed as choledocholithiasis and cholangitis in the local hospital are described. We analyzed retrospectively and summarized our experiences of these 5 HCC patients with BDTT misdiagnosed in the local hospital during the past 5 years. The diagnosis, treatment, and outcome of the patients are discussed. Three patients underwent hepatectomy with thrombectomy and T-tube drainage. One patient underwent hepatectomy with the resection of the common bile duct and hepatojejunostomy, and palliative surgery was performed in 1 patient with portal vein tumor thrombus and intrahepatic metastasis. The patients were followed for 6-22 months; 4 patients died of tumor recurrence and metastasis or hepatic failure, despite 3 of these patients having received transhepatic arterial chemotherapy and embolization or radiofrequency ablation therapy. Early and accurate diagnosis of HCC with BDTT is very important. When patients have a history of abnormal recurrent cholangitis, HCC with BDTT should be highly suspected. Intraductal ultrasonography (US), intraoperative US, and histopathological examination are very valuable for the diagnosis. The prognosis of HCC patients with BDTT is dismal. Identification of this type of patient is clinically important, because surgical treatment may be beneficial. PMID:25192487

Wu, Zheng; Guo, Kun; Sun, Hao; Yu, Liang; Lv, Yi; Wang, Bo

2014-09-01

367

Vulvar cancer: epidemiology, clinical presentation, and management options  

PubMed Central

Epidemiology Vulvar cancer can be classified into two groups according to predisposing factors: the first type correlates with a HPV infection and occurs mostly in younger patients. The second group is not HPV associated and occurs often in elderly women without neoplastic epithelial disorders. Histology Squamous cell carcinoma (SCC) is the most common malignant tumor of the vulva (95%). Clinical features Pruritus is the most common and long-lasting reported symptom of vulvar cancer, followed by vulvar bleeding, discharge, dysuria, and pain. Therapy The gold standard for even a small invasive carcinoma of the vulva was historically radical vulvectomy with removal of the tumor with a wide margin followed by an en bloc resection of the inguinal and often the pelvic lymph nodes. Currently, a more individualized and less radical treatment is suggested: a radical wide local excision is possible in the case of localized lesions (T1). A sentinel lymph node (SLN) biopsy may be performed to reduce wound complications and lymphedema. Prognosis The survival of patients with vulvar cancer is good when convenient therapy is arranged quickly after initial diagnosis. Inguinal and/or femoral node involvement is the most significant prognostic factor for survival. PMID:25848321

Alkatout, Ibrahim; Schubert, Melanie; Garbrecht, Nele; Weigel, Marion Tina; Jonat, Walter; Mundhenke, Christoph; Günther, Veronika

2015-01-01

368

C. elegans Dopaminergic D2-Like Receptors Delimit Recurrent Cholinergic-Mediated Motor Programs during a Goal-Oriented Behavior  

PubMed Central

Caenorhabditis elegans male copulation requires coordinated temporal-spatial execution of different motor outputs. During mating, a cloacal circuit consisting of cholinergic sensory-motor neurons and sex muscles maintains the male's position and executes copulatory spicule thrusts at his mate's vulva. However, distinct signaling mechanisms that delimit these behaviors to their proper context are unclear. We found that dopamine (DA) signaling directs copulatory spicule insertion attempts to the hermaphrodite vulva by dampening spurious stimulus-independent sex muscle contractions. From pharmacology and genetic analyses, DA antagonizes stimulatory ACh signaling via the D2-like receptors, DOP-2 and DOP-3, and G?o/i proteins, GOA-1 and GPA-7. Calcium imaging and optogenetics suggest that heightened DA-expressing ray neuron activities coincide with the cholinergic cloacal ganglia function during spicule insertion attempts. D2-like receptor signaling also attenuates the excitability of additional mating circuits to reduce the duration of mating attempts with unproductive and/or inappropriate partners. This suggests that, during wild-type mating, simultaneous DA-ACh signaling modulates the activity threshold of repetitive motor programs, thus confining the behavior to the proper situational context. PMID:23166505

Correa, Paola; LeBoeuf, Brigitte; García, L. René

2012-01-01

369

Changes in Men’s Salivary Testosterone and Cortisol Levels, and in Sexual Desire after Smelling Female Axillary and Vulvar Scents  

PubMed Central

Several studies have shown that a woman’s vaginal or axillary odors convey information on her attractivity. Yet, whether such scents induce psychoneuroendocrinological changes in perceivers is still controversial. We studied if smelling axillary and vulvar odors collected in the periovulatory and late luteal phases of young women modify salivary testosterone and cortisol levels, as well as sexual desire in men. Forty-five women and 115 men, all of them college students and unacquainted with each other, participated in the study. Female odors were collected on pads affixed to the axilla and on panty protectors both worn the entire night before experiments. Men provided five saliva samples, a basal one before the smelling procedure, and four more 15, 30, 60, and 75?min after exposure to odors. Immediately after smelling the odor source, men answered a questionnaire rating hedonic qualities of scents, and after providing the last saliva sample they answered questionnaire on sexual desire. We found that periovulatory axillary and vulvar odors increased testosterone and cortisol levels, with vulvar scents producing a more prolonged effect. Luteal axilla odors decreased testosterone and cortisol levels, while luteal vulva odors increased cortisol. Periovulatory axilla and vulva scents accounted for a general increase of interest in sex. These odors were also rated as more pleasant and familiar, while luteal vulvar odors were perceived as intense and unpleasant. PMID:24194730

Cerda-Molina, Ana Lilia; Hernández-López, Leonor; de la O, Claudio E.; Chavira-Ramírez, Roberto; Mondragón-Ceballos, Ricardo

2013-01-01

370

Calcaridorylaimus castaneae sp. n. (Nematoda, Dorylaimidae) from Bulgaria with an identification key to the species of the genus  

PubMed Central

Abstract An unknown species belonging to the genusCalcaridorylaimus Andrássy, 1986 was collected from the litter of broadleaf forests dominated by Castanea sativa Mill. and mixed with Quercus daleshampii Ten. and Fagus sylvatica L. on Belasitsa Mountain, south-western Bulgaria. Calcaridorylaimus castaneae sp. n. is characterised by its long body (1.4–2.1 mm), lip region practically not offset, vulva transverse, short odontostyle (14.5–16 ?m) and tail (75.5–110.5 ?m, c=14.7–23.6; c’=2.9–4.4) in females and 38–46 ?m long spicules with small spur before their distant end in males. It is most similar to C. andrassyi Ahmad & Shaheen, 2004, but differs in having transverse vs pore-like vulva and shorter spicules (38–46 ?m vs 52–57 ?m). An identification key to the species of the genus Calcaridorylaimus is proposed. Phylogenetic analyses were performed on 18S and D2-D3 expansion domains of 28S rRNA genes by Neighbor-Joining, Maximum Likelihood and Bayesian Inference methods. The phylograms inferred from 18S sequences showed closest relationships of the new species with some species belonging to the genus Mesodorylaimus. However, insufficient molecular data for members of both genera do not allow the phylogenetic relationships of Calcaridorylaimus and the new species described herein to be elucidated. PMID:24899849

Nedelchev, Sevdan; Elshishka, Milka; Lazarova, Stela; Radoslavov, Georgi; Hristov, Peter; Peneva, Vlada

2014-01-01

371

Cryphodera sinensis n. sp. (Nematoda: Heteroderidae), a non-cyst-forming parasitic nematode from the root of ramie Boehmeria nivea in China.  

PubMed

Cryphodera sinensis n. sp. is described from ramie (Boehmeria nivea) based on the morphology and molecular analyses of rRNA small subunit (SSU), D2D3 expansion domains of large subunit (LSU D2D3) and internal transcribed spacer (ITS). This new species is characterized by oval females with a distinct subcrystalline layer and pronounced and protruding vulval lip, distinctly concave vulva-anus profile and a vulva-anus distance of 29.5-35.8 ?m. Males possess two annuli in the lip region, a stylet 27-32.5 ?m in length with round knobs sloping slightly posteriorly, lateral fields with three lines, spicules 20-28 ?m long and the presence of a short cloacal tube. Second-stage juveniles possess three lip annuli, a stylet 28-31 ?m in length with well-developed knobs projected anteriorly and three lines along the lateral field. The pointed tail, 52-65 ?m long, possesses a mucro-like tip and a hyaline region, 24.5-35 ?m long. Large phasmids with a lens-like structure are located 2-6 annuli posterior to the anus. Phylogenetic analysis shows that the species has unique SSU, LSU D2D3 and ITS rRNA sequences. Phylogenetic relationships of the three rDNA sequences of C. sinensis n. sp. and other cystoid/cyst nematodes are analysed together with a comparison of other species within the genus Cryphodera. PMID:23782683

Zhuo, K; Wang, H H; Ye, W; Peng, D L; Liao, J L

2014-12-01

372

New insights into morphological features of Hadjelia truncata (Spirurida: Habronematidae), as revealed by SEM.  

PubMed

Hadjelia truncata (Spirurida: Habronematidae) is a nematode found in the gizzard of several avian species. However, it has been reported pathogenic only in pigeons (Columba livia), in which it causes severe ventriculitis. Scanning electron microscopy (SEM) was used to study the morphological aspects of adult worms of this nematode in detail. Males and females measured 6.5-9 and 12-16.5 mm, respectively. The bodies were straight with moderate uniform thickness in both males and females, narrowing at the anterior end. The cuticle was striated transversely. The mouth was surrounded by two lateral trilobed lips, and the dorsal and ventral interlabia were present. The two cephalic papillae were present on each side lodged just behind the upper and lower bases of each lip. Around the mouth, a large amphid was seen on each lip. At the anterior end of both male and female worms, an excretory pore on the ventral side and a pair of lateral cervical papillae were observed. In the female, the vulva was located at the anterior end of the body. The lips of the vulva protruded above the body surface, and the bluntly rounded posterior end showed an anal pore and two subterminal phasmids. The posterior end of the males curved ventrally, with large caudal alae supported by four pairs of stalked precloacal papillae, a single medial precloacal papilla, two pairs of postcloacal papillae, and a cluster of small papillae on the caudal extremity. Spicules were unequal and dissimilar. PMID:23064811

Naem, Soraya; Houston, Robin S; Sentíes-Cué, Gabriel

2013-01-01

373

Subunit Principle of Vulvar Reconstruction: Algorithm and Outcomes  

PubMed Central

Background Vulvar defects result chiefly from oncologic resection of vulvar tumors. Reconstruction of vulvar defects restores form and function for the purpose of coitus, micturition, and defecation. Many surgical options exist for vulvar reconstruction. The purpose of this article is to present our experience with vulvar reconstruction. Methods From 2007 to 2013, 43 women presented to us with vulvar defects for reconstruction. Their mean age at the time of reconstruction was 61.1 years. The most common cause of vulvar defect was from resection of vulvar carcinoma and extramammary Paget's disease of the vulva. Method s of reconstruction ranged from primary closure to skin grafting to the use of pedicled flaps. Results The main complications were that of long term hypertrophic and/or unaesthetic scarring of the donor site in 4 patients. Twenty-two patients (51%) were able to resume sexual intercourse. There were no complications of flap loss, wound dehiscence, and urethral stenosis. Conclusions We present a subunit algorithmic approach to vulvar reconstruction based on defect location within the vulva, dimension of the defect, and patient age and comorbidity. The gracilis and gluteal fold flaps are particularly versatile and aesthetically suited for reconstruction of a variety of vulvar defects. From an aesthetic viewpoint the gluteal fold flap was superior because of the well-concealed donor scar. We advocate the routine use of these 2 flaps for vulvar reconstruction. PMID:25075361

Kang, Gavin Chun-Wui; Tay, Eng Hseon; Por, Yong Chen

2014-01-01

374

Chromatin regulation and sumoylation in the inhibition of Ras-induced vulval development in Caenorhabditis elegans  

PubMed Central

In Caenorhabditis elegans, numerous ‘synMuv' (synthetic multivulval) genes encode for chromatin-associated proteins involved in transcriptional repression, including an orthologue of Rb and components of the NuRD histone deacetylase complex. These genes antagonize Ras signalling to prevent erroneous adoption of vulval fate. To identify new components of this mechanism, we performed a genome-wide RNA interference (RNAi) screen. After RNAi of 16 757 genes, we found nine new synMuv genes. Based on predicted functions and genetic epistasis experiments, we propose that at least four post-translational modifications converge to inhibit Ras-stimulated vulval development: sumoylation, histone tail deacetylation, methylation, and acetylation. In addition, we demonstrate a novel role for sumoylation in inhibiting LIN-12/Notch signalling in the vulva. We further show that many of the synMuv genes are involved in gene regulation outside the vulva, negatively regulating the expression of the Delta homologue lag-2. As most of the genes identified in this screen are conserved in humans, we suggest that similar interactions may be relevant in mammals for control of Ras and Notch signalling, crosstalk between these pathways, and cell proliferation. PMID:15990876

Poulin, Gino; Dong, Yan; Fraser, Andrew G; Hopper, Neil A; Ahringer, Julie

2005-01-01

375

A Cholinergic-Regulated Circuit Coordinates the Maintenance and Bi-Stable States of a Sensory-Motor Behavior during Caenorhabditis elegans Male Copulation  

PubMed Central

Penetration of a male copulatory organ into a suitable mate is a conserved and necessary behavioral step for most terrestrial matings; however, the detailed molecular and cellular mechanisms for this distinct social interaction have not been elucidated in any animal. During mating, the Caenorhabditis elegans male cloaca is maintained over the hermaphrodite's vulva as he attempts to insert his copulatory spicules. Rhythmic spicule thrusts cease when insertion is sensed. Circuit components consisting of sensory/motor neurons and sex muscles for these steps have been previously identified, but it was unclear how their outputs are integrated to generate a coordinated behavior pattern. Here, we show that cholinergic signaling between the cloacal sensory/motor neurons and the posterior sex muscles sustains genital contact between the sexes. Simultaneously, via gap junctions, signaling from these muscles is transmitted to the spicule muscles, thus coupling repeated spicule thrusts with vulval contact. To transit from rhythmic to sustained muscle contraction during penetration, the SPC sensory-motor neurons integrate the signal of spicule's position in the vulva with inputs from the hook and cloacal sensilla. The UNC-103 K+ channel maintains a high excitability threshold in the circuit, so that sustained spicule muscle contraction is not stimulated by fewer inputs. We demonstrate that coordination of sensory inputs and motor outputs used to initiate, maintain, self-monitor, and complete an innate behavior is accomplished via the coupling of a few circuit components. PMID:21423722

Liu, Yishi; LeBeouf, Brigitte; Guo, Xiaoyan; Correa, Paola A.; Gualberto, Daisy G.; Lints, Robyn; Garcia, L. Rene

2011-01-01

376

Genetic Structure Analysis of Spirometra erinaceieuropaei Isolates from Central and Southern China  

PubMed Central

Background Sparganosis caused by invasion of the plerocercoid larvae (spargana) of Spirometra erinaceieuropaei have increased in recent years in China. However, the population genetic structure regarding this parasite is still unclear. In this study, we used the sequences of two mitochondrial genes cytochrome b (cytb) and cytochrome c oxidase subunit I (cox1) to analyze genetic variation and phylogeographic structure of the S. erinaceieuropaei populations. Methodology/Principal Findings A total of 88 S. erinaceieuropaei isolates were collected from naturally infected frogs in 14 geographical locations of China. The complete cytb and cox1 genes of each sample was amplified and sequenced. Total 61 haplotypes were found in these 88 concatenated sequences. Each sampled population and the total population have high haplotype diversity (Hd), accompanied by very low nucleotide diversity (Pi). Phylogenetic analyses of haplotypes revealed two distinct clades (HeN+HuN+GZ-AS clade and GX+HN+GZ-GY clade) corresponding two sub-networks yielded by the median-joining network. Pairwise FST values supported great genetic differentiation between S. erinaceieuropaei populations. Both negative Fu’s FS value of neutrality tests and unimodal curve of mismatch distribution analyses supported demographic population expansion in the HeN+HuN+GZ-AS clade. The BEAST analysis showed that the divergence time between the two clades took place in the early Pleistocene (1.16 Myr), and by Bayesian skyline plot (BSP) an expansion occurred after about 0.3 Myr ago. Conclusions S. erinaceieuropaei from central and southern China has significant phylogeographic structure, and climatic oscillations during glacial periods in the Quaternary may affect the demography and diversification of this species. PMID:25793277

Zhang, Xi; Cui, Jing; Liu, Li Na; Jiang, Peng; Wang, Han; Qi, Xin; Wu, Xing Qi; Wang, Zhong Quan

2015-01-01

377

The Burden of Parasitic Zoonoses in Nepal: A Systematic Review  

PubMed Central

Background Parasitic zoonoses (PZs) pose a significant but often neglected threat to public health, especially in developing countries. In order to obtain a better understanding of their health impact, summary measures of population health may be calculated, such as the Disability-Adjusted Life Year (DALY). However, the data required to calculate such measures are often not readily available for these diseases, which may lead to a vicious circle of under-recognition and under-funding. Methodology We examined the burden of PZs in Nepal through a systematic review of online and offline data sources. PZs were classified qualitatively according to endemicity, and where possible a quantitative burden assessment was conducted in terms of the annual number of incident cases, deaths and DALYs. Principal Findings Between 2000 and 2012, the highest annual burden was imposed by neurocysticercosis and congenital toxoplasmosis (14,268 DALYs [95% Credibility Interval (CrI): 5450–27,694] and 9255 DALYs [95% CrI: 6135–13,292], respectively), followed by cystic echinococcosis (251 DALYs [95% CrI: 105–458]). Nepal is probably endemic for trichinellosis, toxocarosis, diphyllobothriosis, foodborne trematodosis, taeniosis, and zoonotic intestinal helminthic and protozoal infections, but insufficient data were available to quantify their health impact. Sporadic cases of alveolar echinococcosis, angiostrongylosis, capillariosis, dirofilariosis, gnathostomosis, sparganosis and cutaneous leishmaniosis may occur. Conclusions/Significance In settings with limited surveillance capacity, it is possible to quantify the health impact of PZs and other neglected diseases, thereby interrupting the vicious circle of neglect. In Nepal, we found that several PZs are endemic and are imposing a significant burden to public health, higher than that of malaria, and comparable to that of HIV/AIDS. However, several critical data gaps remain. Enhanced surveillance for the endemic PZs identified in this study would enable additional burden estimates, and a more complete picture of the impact of these diseases. PMID:24392178

Devleesschauwer, Brecht; Ale, Anita; Torgerson, Paul; Praet, Nicolas; Maertens de Noordhout, Charline; Pandey, Basu Dev; Pun, Sher Bahadur; Lake, Rob; Vercruysse, Jozef; Joshi, Durga Datt; Havelaar, Arie H.; Duchateau, Luc; Dorny, Pierre; Speybroeck, Niko

2014-01-01

378

Solar ultraviolet-B exposure and cancer incidence and mortality in the United States, 1993–2002  

PubMed Central

Background An inverse relationship between solar ultraviolet-B (UV-B) exposure and non-skin cancer mortality has long been reported. Vitamin D, acquired primarily through exposure to the sun via the skin, is believed to inhibit tumor development and growth and reduce mortality for certain cancers. Methods We extend the analysis of this relationship to include cancer incidence as well as mortality, using higher quality and higher resolution data sets than have typically been available. Over three million incident cancer cases between 1998 and 2002 and three million cancer deaths between 1993 and 2002 in the continental United States were regressed against daily satellite-measured solar UV-B levels, adjusting for numerous confounders. Relative risks of reduced solar UV-B exposure were calculated for thirty-two different cancer sites. Results For non-Hispanic whites, an inverse relationship between solar UV-B exposure and cancer incidence and mortality was observed for ten sites: bladder, colon, Hodgkin lymphoma, myeloma, other biliary, prostate, rectum, stomach, uterus, and vulva. Weaker evidence of an inverse relationship was observed for six sites: breast, kidney, leukemia, non-Hodgkin lymphoma, pancreas, and small intestine. For three sites, inverse relationships were seen that varied markedly by sex: esophagus (stronger in males than females), gallbladder (stronger in females than males), and thyroid (only seen in females). No association was found for bone and joint, brain, larynx, liver, nasal cavity, ovary, soft tissue, male thyroid, and miscellaneous cancers. A positive association between solar UV-B exposure and cancer mortality and incidence was found for anus, cervix, oral cavity, melanoma, and other non-epithelial skin cancer. Conclusion This paper adds to the mounting evidence for the influential role of solar UV-B exposure on cancer, particularly for some of the less-well studied digestive cancers. The relative risks for cancer incidence are similar to those for cancer mortality for most sites. For several sites (breast, colon, rectum, esophagus, other biliary, vulva), the relative risks of mortality are higher, possibly suggesting that the maintenance of adequate vitamin D levels is more critical for limiting tumor progression than for preventing tumor onset. Our findings are generally consistent with the published literature, and include three cancer sites not previously linked with solar UV-B exposure, to our knowledge: leukemia, small intestine, and vulva. PMID:17096841

Boscoe, Francis P; Schymura, Maria J

2006-01-01

379

Cutaneous furuncular myiasis: Human infestation by the botfly.  

PubMed

Dermatobia hominis, the botfly, is indigenous to Central and South America. Its usual host is a mammal, often a horse or cow. Cutaneous furuncular myiasis, human infestation by the botfly, has rarely been reported. Symptoms of infestation include a locally painful, firm furuncular lesion, often with a centrally located pore. Due to their infrequent occurrence, these lesions are often misdiagnosed as cellulitis, leishmaniasis, furunculosis, staphylococcal boil, insect bite or sebaceous cyst - conditions with similar presentations. The present case reiterates the need to think of 'zebras' when hearing 'hoof beats' that may have originated in a different land. PMID:19554228

Jacobs, Bryan; Brown, David L

2006-01-01

380

Cutaneous furuncular myiasis: Human infestation by the botfly  

PubMed Central

Dermatobia hominis, the botfly, is indigenous to Central and South America. Its usual host is a mammal, often a horse or cow. Cutaneous furuncular myiasis, human infestation by the botfly, has rarely been reported. Symptoms of infestation include a locally painful, firm furuncular lesion, often with a centrally located pore. Due to their infrequent occurrence, these lesions are often misdiagnosed as cellulitis, leishmaniasis, furunculosis, staphylococcal boil, insect bite or sebaceous cyst – conditions with similar presentations. The present case reiterates the need to think of ‘zebras’ when hearing ‘hoof beats’ that may have originated in a different land. PMID:19554228

Jacobs, Bryan; Brown, David L

2006-01-01

381

A minimal form of Proteus syndrome presenting with macrodactyly and hand hyperplasia.  

PubMed

Proteus syndrome is a rare congenital disorder characterized by progressive course and great variability of clinical presentation with partial gigantism of extremities, hemihyperplasia with macrocephaly, epidermal nevus, mesodermal hamartomas and the presence of peculiar cerebriform masses on the palms/soles. Many atypical cases have been reported and this is probably due to the mosaicism of the genetic disorder displaying different clinical features. We describe a patient with an extremely mild form of Proteus syndrome presenting macrodactyly and hyperplasia of one hand which was misdiagnosed until the age of 33 years. PMID:12695139

Morelli, Federica; Feliciani, Claudio; Toto, Paola; De Benedetto, Anna; Tulli, Antonello

2003-01-01

382

Treatment of extensor digitorum brevis manus myalgia with botulinum toxin.  

PubMed

Extensor digitorum brevis manus (EDBM) muscles are accessory dorsal hand muscles that are present in 1%-3% of the population. These muscles are not commonly symptomatic, but they can occasionally cause pain and discomfort and may be misdiagnosed as tenosynovitis or a ganglion cyst. In this case, we describe an appropriate workup of dorsal hand masses and myalgia that are suspected to be related to EDBM muscles. The patient's symptoms were controlled with injections of botulinum toxin into the EDMB muscle belly, which allowed the patient to be relatively pain free for a considerable amount of time and avoid surgery. PMID:24368092

Wendel, Ian; Cole, Jeffrey

2014-03-01

383

Misdiagnosis of Abdominal Pain in Pregnancy: Acute Pancreatitis  

PubMed Central

We report a case of acute pancreatitis in a pregnant woman who presented to our emergency department with complaints of severe abdominal pain, was misdiagnosed as scar dehiscence and underwent emergency repeat caesarean section at 33 wks for fetal distress. The preterm baby developed severe respiratory distress and succumbed on the second postnatal day. Persistent severe pain in the postoperative period in the mother prompted further evaluation which led to a diagnosis of acute pancreatitis. Conservative and supportive management was instituted leading to an eventual favourable maternal outcome. PMID:25738042

Samal, Sunita; Gupta, Shweta; Begum, Jasmina; Ghose, Seetesh

2015-01-01

384

Orbital Rosai–Dorfman Disease in a fifty-eight years old woman  

PubMed Central

Rosai–Dorfman disease (RDD) is rare and characterized by histiocytic proliferation and massive cervical lymphadenopathy. About 40% of patients have extra-nodal involvement. Opthalmic involvement is seen in 10% of cases. A case of orbital Rosai Dorfman disease in a 58 years old woman is presented here, who was misdiagnosed as orbital inflammatory disease initially. The patient did not respond to a course of oral prednisolone. Then complete surgical excision of the mass was performed and the histopathological examination was consistent with a diagnosis of RDD. PMID:24353690

Li, Hui-Yan; Cui, Hong-Guang; Zheng, Xue-Yong; Ren, Guo-Ping; Gu, Yang-Shun

2013-01-01

385

Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE): case report with a new mutation  

Microsoft Academic Search

Introduction  Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) is a rare autosomal recessive multisystem disorder characterized\\u000a by severe gastrointestinal dysmotility and leads to cachexia, ptosis, external ophthalmoplegia, peripheral neuropathy, and\\u000a leukoencephalopathy.\\u000a \\u000a \\u000a \\u000a \\u000a Results and discussion  It is often misdiagnosed as anorexia nervosa or intestinal pseudoobstuctions and are unnecessarily treated with surgery. It\\u000a has been established that MNGIE is caused by mutations in the gene encoding thymidine

Zeren Bar??; Tuba Emino?lu; Buket Dalg?ç; Leyla Tümer; Alev Hasano?lu

2010-01-01

386

Preeclampsia as the great impostor.  

PubMed

In contrast with a generation ago when preeclampsia was misdiagnosed as medical or surgical disease unrelated to pregnancy, today's diagnostic errors are those that consider surgical and medical problems as either pregnancy-induced hypertension or as the hemolysis, elevated liver enzymes, and low platelet count syndrome. Eleven case histories are presented of significant medical or surgical problems that were initially diagnosed as hemolysis, elevated liver enzymes, and low platelet count syndrome or pregnancy-induced hypertension. The incorrect diagnosis of medical-surgical cases during pregnancy often meant that appropriate therapy was delayed and that the rate of iatrogenic prematurity was increased. PMID:2048605

Goodlin, R C

1991-06-01

387

Plexiform Unicystic Ameloblastoma: A Rare Variant of Ameloblastoma  

PubMed Central

The term plexiform unicystic ameloblastoma refers to a pattern of epithelial proliferation that has been described in cystic cavity. Because of unilocular presentation, it is commonly misdiagnosed as an odontogenic cyst. However, they may often behave clinically as biologically aggressive tumors. These tumors show high incidence of cortical perforation, tooth resorption and a high rate of recurrence after simple enucleation. This paper aims to provide an insight into this biologically distinct entity. A literature review on the topic has been added along with a case report highlighting the approach of diagnosis and management of such ameloblastomas. PMID:25202458

Deore, Swapnil S.; Dandekar, Rishikesh C.; Mahajan, Aarti M.; Patil, Rahul; Prakash, Nilima

2014-01-01

388

A case of negative pressure pulmonary edema in an asthmatic patient after laparoscopic cholecystectomy  

PubMed Central

Negative pressure pulmonary edema is often misdiagnosed or can go clinically unrecognized by anesthesiologists. It is characterized by a markedly low intrapleural pressure which leads to exudation of fluid and red blood cells in the interstitium. Recognition of patients with predisposing factors for upper airway obstruction is important in the diagnosis which is often confused with pulmonary aspiration of gastric contents. Signs and symptoms are subtle and edema is usually self-limited. Our patient was management conservatively with maintenance of a patent airway and administration of supplemental oxygen and had a successful outcome.

Rasheed, Asim; Palaria, Urmila; Rani, Dolly; Sharma, Shatrunjay

2014-01-01

389

Neurosyphilis with psychotic symptoms and Parkinsonism in a young girl.  

PubMed

A 15-year-old girl with neurosyphilis was misdiagnosed as having viral encephalitis with psychotic symptoms and Parkinsonism. We found that she was experiencing visual hallucinations, persecutory delusions, flattening of affect, poorness of thought, tremors, four-limb rigidity, and restlessness, and she was unable to communicate with others. The Venereal Disease Research Laboratory serum test and further lumbar puncture enabled us to diagnose her with neurosyphilis. After antibiotic treatment, her psychotic symptoms and Parkinsonism were relieved. From this case, we believe that it is important to keep organic psychosis in mind during the diagnostic workup, and we argue that routine syphilis screening is necessary in psychiatry clinical practice. PMID:25733837

Yin, Li; Zou, Shoukang; Huang, Yi

2015-01-01

390

Damaged ligaments at the craniocervical junction presenting as an extradural tumour: a differential diagnosis in the elderly.  

PubMed Central

An extradural mass at the craniocervical junction causing progressive neurological disability in five elderly patients is described. The lesion, which might be confused with a meningioma or other tumour, is composed of amorphous degenerate fibrocartilaginous material and could be due to degeneration of the ligaments responsible for atlanto-axial stability. Recognition of the condition early is important as the patient's clinical condition will deteriorate without decompression. Anterior transoral removal is relatively simple, unlike surgery for tumours in the area, and will not destabilise the craniovertebral junction. It is likely that a proportion of these lesions are undetected, misdiagnosed or untreated to the detriment of the patient. Images PMID:1955901

Crockard, H A; Sett, P; Geddes, J F; Stevens, J M; Kendall, B E; Pringle, J A

1991-01-01

391

A clinical chameleon: postoperative hypoparathyroidism  

Microsoft Academic Search

Background  About 1,200 patients per year develop postoperative hypoparathyroidism alone in Germany. Many of those patients may be misdiagnosed\\u000a as the symptoms of this disease may vary and can be atypical.\\u000a \\u000a \\u000a \\u000a Patient\\/results  As an example, we describe the first known case of an elderly patient with a long history of seizures as a complication of\\u000a an undiagnosed chronic hypoparathyroidism after surgery of

Thomas Bohrer; Mark Hagemeister; Olaf Elert

2007-01-01

392

Spiders and Other Arachnids at UC Riverside  

NSDL National Science Digital Library

This page provides information on venomous spiders and other stinging or biting arthropods, especially the brown recluse spider. Topics include the distribution and misidentification of the brown recluse, misdiagnoses of brown recluse bites, how to identify this species, and popular myths surrounding it. There is also information on daddy-longlegs (Opiliones)and daddy-longlegs spiders (Pholcidae), hobo spiders (Tegenaria agrestis), internet hoaxes involving spiders, and an article on bites and stings of medically important venomous arthropods (bees, wasps, ants, spiders, and scorpions).

Rick Vetter

393

Follicular dendritic cell sarcoma of parapharyngeal space: a case report and review of the literature.  

PubMed

Follicular dendritic cell sarcoma (FDCS) of the parapharyngeal space is a rare malignant tumor. Only eleven cases of FDCS of the parapharyngeal space have been reported in English literature. Most of the reported cases developed tumor recurrence within 1 year or had metastasis. Because of the rarity of FDCS in the parapharyngeal space and peculiar histology, it can be misdiagnosed as undifferentiated carcinoma or meningioma. Therefore, pathologists should be aware of the existence of FDCS in this location. This paper aims to report a unique case of FDCS of the parapharyngeal space without recurrence in 26 months follow up with a review of the literature. PMID:24668593

Al-Hussain, Turki; Saleem, Muhammad; Velagapudi, Suresh Babu; Dababo, Mohammad Anas

2015-03-01

394

Pitfalls in colour photography of choroidal tumours  

PubMed Central

Colour imaging of fundus tumours has been transformed by the development of digital and confocal scanning laser photography. These advances provide numerous benefits, such as panoramic images, increased contrast, non-contact wide-angle imaging, non-mydriatic photography, and simultaneous angiography. False tumour colour representation can, however, cause serious diagnostic errors. Large choroidal tumours can be totally invisible on angiography. Pseudogrowth can occur because of artefacts caused by different methods of fundus illumination, movement of reference blood vessels, and flattening of Bruch's membrane and sclera when tumour regression occurs. Awareness of these pitfalls should prevent the clinician from misdiagnosing tumours and wrongfully concluding that a tumour has grown. PMID:23238442

Schalenbourg, A; Zografos, L

2013-01-01

395

Pilomatrixoma of the breast, a rare lesion simulating breast cancer: a case report  

PubMed Central

Pilomatrixoma or calcifying epithelioma of Malherbe is a rare, benign, skin tumour originating from piliferous follicles; breast localization is considered to be very rare. These lesions can origin from the peri-areolar piliferous bulbs and, due to the clinical and imaging features, be easily misdiagnosed as a breast neoplasm. We present a case of pilomatrixoma of the left breast in a woman of 43 years appearing as a firm, deep nodule in the external quadrants. The lesion had mammographic and sonographic malignant features, but histological analysis on core-needle biopsy and surgical specimens revealed this unusual benign lesion. PMID:24421922

Nori, Jacopo; Abdulcadir, Dalmar; Giannotti, Elisabetta; Calabrese, Massimo

2013-01-01

396

An analysis of the diagnostic methods for acute pulmonary embolism.  

PubMed

In spite of numerous sophisticated investigative procedures, acute pulmonary embolism (PE) is very frequently misdiagnosed. In order to improve the diagnostic approach to PE, the sensitivity and specificity of the commonly used methods were reviewed in a group of 421 patients with angiographically proved PE without associated cardio-pulmonary disease. The specificity of diagnostic procedures was, by decreasing order: positive pulmonary angiography (to affirm) = negative perfusion lung scan (to eliminate) greater than chest X-ray much greater than clinical symptoms, positive perfusion lung scan, ECG, blood gas, serum enzymes. PMID:6425382

Sors, H; Safran, D; Stern, M; Reynaud, P; Bons, J; Even, P

1984-01-01

397

Aneurysmal Bone Cysts of the Spine: Two Case Reports  

PubMed Central

Aneurysmal bone cysts are rare entities which causes expansile and destructive bone lesions characterized by reactive proliferation of connective tissue. They usually grow rapidly with hypervascularity. In clinical practice they can be easily misdiagnosed due to the rare occurance and having no such typical findings as radiologically. Most cases have uncommon pain symptoms, but rarely, if fractures occur, neurological findings can be seen and the surgical treatment, if needed, could be difficult. We will discuss our evaluations to two cases that we experienced in our clinic in this report. PMID:25620988

Ozdemir, Seymen; Ozden, Ferhat; Kacira, Ozlem Kitiki; Kacira, Tibet

2014-01-01

398

Aneurysmal bone cysts of the spine: two case reports.  

PubMed

Aneurysmal bone cysts are rare entities which causes expansile and destructive bone lesions characterized by reactive proliferation of connective tissue. They usually grow rapidly with hypervascularity. In clinical practice they can be easily misdiagnosed due to the rare occurance and having no such typical findings as radiologically. Most cases have uncommon pain symptoms, but rarely, if fractures occur, neurological findings can be seen and the surgical treatment, if needed, could be difficult. We will discuss our evaluations to two cases that we experienced in our clinic in this report. PMID:25620988

Ozdemir, Seymen; Yaldiz, Can; Ozden, Ferhat; Kacira, Ozlem Kitiki; Kacira, Tibet

2014-12-01

399

Scoliosis secondary to ganglioneuroma: a case report and up to date literature review.  

PubMed

Idiopathic scoliosis is the most common form of spinal deformity in children. However, secondary causes of scoliosis, such as ganglioneuroma, should be always considered to avoid wrong diagnosis, and further investigations are required when there are atypical signs. We report a case of ganglioneuroma misdiagnosed as idiopathic scoliosis and review the literature to identify the red flags useful for physicians during the evaluation of a child with scoliosis. On the basis of both clinical and radiographic criteria that emerged from this study, we propose an algorithm that could help in the differential diagnosis, suggesting when to perform an MRI. PMID:24681491

D'Eufemia, Patrizia; Properzi, Enrico; Palombaro, Marta; Lodato, Valentina; Mellino, Loretta; Tetti, Martina; Martini, Lorena; Persiani, Pietro

2014-07-01

400

Distal renal tubular acidosis associated with Sjogren syndrome.  

PubMed

Renal tubular acidosis is a common cause of normal anion gap metabolic acidosis but these disorders can be easily missed or misdiagnosed. We highlight the approach to assessing renal tubular acidosis by discussing a case study with a temporal data set collected over more than 5 weeks. We highlight the principles and the necessary information required for a diagnosis of classic distal renal tubular acidosis. We also briefly review several aspects of type 1 renal tubular acidosis related to autoimmune disease, drugs and thyroid disorders. PMID:24330363

Lim, A K H; Choi, M J

2013-12-01

401

Candida albicans keratitis in an immunocompromised patient  

PubMed Central

Purpose When investigating a case of unexplained corneal ulceration, we need to think of fungal infection and any predisposing factors. Methods A case study of a corneal ulceration in a patient who was HIV positive with a devastating visual outcome. Results Therapeutic corneal graft was necessary due to corneal perforation. Immunocompromised state of patient was retrospectively diagnosed. Conclusions Candida albicans keratitis is an opportunistic infection of a compromised cornea, and sometimes unknowingly compromised host, which can be initially misdiagnosed. Despite intensive antifungal therapy, occasionally patients require corneal grafting to improve vision, and before it is possible to establish an accurate diagnosis. PMID:21060674

Hassan, H Mohammed J; Papanikolaou, Theocharis; Mariatos, Georgios; Hammad, Amany; Hassan, Hala

2010-01-01

402

Childhood ADHD: a stepped diagnosis approach.  

PubMed

Since publication of DSM-IV in 1994, the prevalence of parent-reported diagnosed attentiondeficit/hyperactivity disorder (ADHD) has tripled to more than 10% of children. Although it is hard to know for sure whether ADHD is overdiagnosed, underdiagnosed, or misdiagnosed, it is argued that ADHD is especially prone to diagnostic inflation and overdiagnosis. Therefore, we propose a model of stepped diagnosis for childhood ADHD, which may reduce overdiagnosis without risking undertreatment. Calling attention to stepped diagnosis and formalizing the steps may improve its application in clinical practice. PMID:24847990

Batstra, Laura; Nieweg, Edo H; Pijl, Sipjan; Van Tol, Donald G; Hadders-Algra, Mijna

2014-05-01

403

Intestinal anisakiasis treated successfully with conservative therapy: importance of clinical diagnosis.  

PubMed

Intestinal anisakiasis is not only a rare parasitic disease, but is also difficult to diagnose. The symptoms are not specific and are often very severe and abrupt, and the findings of clinical imaging are very remarkable. Therefore, intestinal anisakiasis is often misdiagnosed as acute abdomen or intestinal obstruction and is treated surgically. However, if intestinal anisakiasis could be diagnosed correctly, it is well treated conservatively. We experienced three cases of intestinal anisakiasis, which were diagnosed correctly and treated successfully with conservative therapy. A correct clinical history and imaging interpretation helped us diagnose intestinal anisakiasis correctly and thus treat the patients successfully with conservative therapy. PMID:24574731

Shrestha, Santosh; Kisino, Akiko; Watanabe, Makoto; Itsukaichi, Hiroshi; Hamasuna, Kazumitsu; Ohno, Giichiro; Tsugu, Atsushi

2014-01-14

404

'Designer drugs': update on the management of novel psychoactive substance misuse in the acute care setting.  

PubMed

The use of novel psychoactive substances ('legal highs' or 'designer drugs') is increasing worldwide. Patients misusing such substances have been reported to experience severe or prolonged side effects requiring admission to acute or critical care wards. These complications can be life threatening if misdiagnosed or mismanaged. As physicians have traditionally had less involvement with the management of such patients compared with their colleagues in emergency departments an update in the management of such patients is indicated. Here we present a summary of the management of those novel substances with the potential for serious complications based on a review of current literature. PMID:25099844

Smith, Christopher D; Robert, Stefanie

2014-08-01

405

Autoimmune Pancreatitis - A Case Report  

PubMed Central

Autoiommune pancreatitis (AIP) is a rare disease that has distinct histological, immunological, serological and radiological findings. It is characterised histologically by lymphoplasmacytic infiltrate, storiform fibrosis, obliterative phelibitis and presence of IgG4 positive plasma cells and lymphocytes. Elevated serum levels of IgG4 are also noted. It is usually misdiagnosed preoperatively as pancreatic cancer. It may involve extrapancreatic sites also and responds well to steroid therapy. Here, we share our experience of AIP in a 52-year-old male.

Rathi, KR; Sahai, Kavita; Jakhmola, CK

2015-01-01

406

Severe hypermagnesemia presenting with abnormal electrocardiographic findings similar to those of hyperkalemia in a child undergoing peritoneal dialysis  

PubMed Central

In this report, we present a pediatric case of severe symptomatic hypermagnesemia resulting from the use of magnesium oxide as a laxative in a child undergoing continuous cyclic peritoneal dialysis for end-stage renal disease. The patient showed abnormal electrocardiography (ECG) findings, such as tall T waves, a widened QRS complex, and irregular conduction, which were initially misdiagnosed as hyperkalemia; later, the correct diagnosis of hypermagnesemia was obtained. Emergent hemodialysis successfully returned the serum magnesium concentration to normal without complications. When abnormal ECG changes are detected in patients with renal failure, hypermagnesemia should be considered. PMID:23908672

Jhang, Won Kyoung; Lee, Yoon Jung; Kim, Young A; Park, Seong Jong

2013-01-01

407

Activists decry physician disinterest in Lyme disease during Vancouver conference.  

PubMed Central

Although it was well advertised, few Canadian physicians attended a recent conference on Lyme disease in Vancouver. The apparent lack of interest upsets the president of the Lyme Borreliosis Society, who says many patients have been misdiagnosed, mistreated or untreated and "are now chronically disabled." Interestingly, the disease seems to be much more common in the US than Canada. In New York State, for instance, more than 26,000 cases have been diagnosed, but in nearby Ontario the total is only 200. PMID:7664235

LeBourdais, E

1995-01-01

408

Cone beam CT assisted re-treatment of class 3 invasive cervical resorption.  

PubMed

Invasive cervical root resorption is an uncommon external root resorption which initiates at the cervical aspect of the tooth. This case report involves a case of cervical root resorption which was initially misdiagnosed and managed as cervical root caries. It was later diagnosed with cone beam CT and the lesion microsurgically removed and restored with resin modified glass ionomer cement. The importance of increasing awareness of this uncommon pathology and the role of cone beam CT in mapping the extent of the lesion is emphasised. PMID:25795743

Krishnan, Unni; Moule, Alex J; Alawadhi, Abdulwahab

2015-01-01

409

Frontotemporal dementia mimicking bipolar disorder.  

PubMed

Frontotemporal dementia is a cause of behavioral disturbance that usually appears in individuals between 45 and 65 years of age. The authors present the case of a 65-year-old patient that illustrates how frontotemporal dementia can be misdiagnosed based on a behavioral pattern that suggests the presence of a primary mood disorder. Early accurate diagnosis of frontotemporal dementia and subsequent supportive measures can allow patients and families to make important decisions about business and legal affairs and how to spend remaining leisure time in the most meaningful and enjoyable way possible. PMID:24241504

Kerstein, Andrew H; Schroeder, Ryan W; Baade, Lyle E; Lincoln, Janka; Khan, Ahsan Y

2013-11-01

410

Aggressive angiomyxoma: a small palpable vulvar lesion with a huge mass in the pelvis.  

PubMed

Aggressive angiomyxoma (AAM) is a rare soft tissue tumor typically in the pelvis and perineum in women of reproductive age, which is easily misdiagnosed. We describe a woman with vulvar AAM, initially mismanaged as a Bartholin cyst. However, a huge pelvic mass is noted on the following imaging studies. The characteristics of AAM on computed tomography and magnetic resonance imaging have been specified in the literature, but we further point out the potential value of sonography in diagnosing AAM. Besides, excisional biopsy may cause tumor bleeding in a case of AAM. PMID:23222052

Huang, Chun-Chao; Sheu, Chin-Yin; Chen, Tung-Ying; Yang, Yuh-Cheng

2013-01-01

411

Importance of accurate preoperative diagnosis in the management of aggressive angiomyxoma: report of three cases and review of the literature  

Microsoft Academic Search

Background:  Aggressive angiomyxoma is a benign but locally aggressive tumor that occurs mostly in young women. Because excision is often\\u000a incomplete, the risk of local recurrence is high. This report describes differences in presentation and the importance of\\u000a accurate preoperative diagnosis of this rare neoplasm.\\u000a \\u000a \\u000a \\u000a Methods and results:  We describe three cases with different presentations. Two were initially misdiagnosed, and local recurrence

A. Wiser; J. Korach; W. H. Gotlieb; E. Fridman; S. Apter; G. Ben-Baruch

2006-01-01

412

Large perineal and gluteal angiomyxoma: the role of diagnostic imaging and literature review.  

PubMed

Aggressive angiomyxoma is a benign soft tissue tumour usually affecting the pelvis and perineum predominantly in women. Because of its variable presentation, this tumour is often clinically misdiagnosed as liposarcoma. We describe a case of a 38-year-old woman who presented with a large perineal and gluteal mass which increased in size in one year. Ultrasound showed hypoechoic mixed solid and cystic mass. Contrasted CT and MRI examinations showed typical appearance of swirling and layering pattern. She had undergone TAHBSO as the mass was difficult to dissect intra-operatively. The post-operative specimen confirmed to be an aggressive angiomyxoma. PMID:23429032

Alhabshi, Sharifah Majedah Idrus; Abd Rashid, M

2013-01-01

413

Small intestine metastasis from cervical cancer with acute abdomen: A case report  

PubMed Central

Cervical cancer metastasis to the small intestine is a rare occurrence that is easily misdiagnosed as a small bowel obstruction. The present study reports the case of a 46-year-old cervical cancer patient with metastasis to the small intestine, which presented as an acute abdomen due to intestinal obstruction. Enteroscopy revealed no primary intestinal tumors. The patient underwent exploratory laparotomy and resection of the tumor of the small intestine. Pathology revealed the mass to be squamous cell carcinoma, limited to the outer muscular layer and serosa. This case demonstrates that small intestine seeding must be considered in the differential diagnosis of acute abdomen in patients with cervical cancer. PMID:25435956

QIU, HUI; YUAN, LIMEI; OU, YANGWEN; ZHU, YAN; XIE, CONGHUA; ZHANG, GONG

2015-01-01

414

Aneurysmal dilatation of persistent vitelline vein with thrombus in a neonate.  

PubMed

The paired vitelline veins selectively involute and form a part of the portal vein during embryonic development. The presence of a persistent vitelline vein segment after birth is very rare and can be confused with anomalies of the portal and umbilical veins. We present sonographic, CT and MRI findings of aneurysmal dilatation of a persistent vitelline vein with thrombus in a neonate; this case was first misdiagnosed as an umbilical vein varix by prenatal US. MRI was used to identify the persistent vitelline vein segment and the remnant umbilical vein segment. PMID:24306734

Kang, Kun Woo; Sung, Deuk Jae; Park, Beom Jin; Kim, Min Ju; Cho, Sung Bum

2014-07-01

415

Angiosarcoma of the penis: a case report and literature review.  

PubMed

We reported one case of penile angiosarcoma in a 49-year-old patient who had been misdiagnosed as syphilis. Based on our experience, we suggest that if sexually transmitted diseases and Peyronie's disease can be ruled out, diagnosis of the penile angiosarcoma be warranted if unexplained rash, ulceration on the penis, and induration in corpus cavernosum are observed. It should be noted that if the anti-inflammatory or anti-viral treatment is prescribed for some time but the lesion does not disappear or even gets worse, the penile angiosarcoma should be suspected and penile biopsy is necessary. PMID:22767178

Wu, Xiaojun; Chen, Zhiwen; Ji, Huixiang; Duan, Guangjie; Zhou, Zhansong

2012-10-01

416

Acroangiodermatitis (pseudo-Kaposi sarcoma): a rarely-recognized condition. A case on the plantar aspect of the foot associated with chronic venous insufficiency.  

PubMed

Acroangiodermatitis, often known as pseudo-Kaposi sarcoma, is an uncommon angioproliferative entity related to chronic venous insufficiency, arteriovenous fistulae, paralysed limbs, amputation stumps, vascular syndromes and conditions associated with thrombosis. It presents most frequently as purple macules, papules or plaques in the dorsal aspects of the feet, especially the toes, and the malleoli. We report a case of acroangiodermatitis in the plantar aspect of the foot, misdiagnosed for two years, in which haematoxylin-eosin hystopathological stain and immunolabeling with CD34 histochemistry examination were decisive for diagnosis. Patient had chronic venous insufficiency. The lesion responded well to the treatment with a combination of leg elevation and compression. PMID:22068760

Pimentel, Maria Inęs Fernandes; Cuzzi, Tullia; Azeredo-Coutinho, Rilza Beatriz Gayoso de; Vasconcellos, Érica de Camargo Ferreira E; Benzi, Tatiana Silva Costa Gregory; Carvalho, Lívia Martins Veloso de

2011-01-01

417

Intramural Hematoma of the Esophagus  

PubMed Central

We report the case of a patient with an intramural hematoma of the esophagus. This rare condition is more common in elderly women and can be misdiagnosed as cardiovascular or other digestive emergent disease. The classical clinical triad includes chest pain, sudden dysphagia or odynophagia and minor hematemesis. Known precipitating factors are Valsalva maneuver, blunt, direct or iatrogenic injuries, but spontaneous cases have also been described. Chest imaging including computed tomography or magnetic resonance imaging as well as upper gastrointestinal endoscopy are useful tools for diagnosis. The treatment is conservative and the prognosis usually excellent with complete resolution within a few weeks. PMID:23730267

Cao, Dahlia Thao; Reny, Jean-Luc; Lanthier, Nicolas; Frossard, Jean-Louis

2012-01-01

418

All that is swollen and red is not infection!  

PubMed Central

Unilateral upper limb extremity swelling and pain are common presentations in clinical practice whose differential diagnoses include cellulitis, abscess, lymphoedema, and venous thrombosis. We report here the case of a renal transplant recipient with an unusual cause of upper extremity swelling and pain. His condition of native radiocephalic, arteriovenous (AV), fistula-related, venous hypertension was misdiagnosed and managed as cellulitis. This case illustrates the importance of an index of suspicion and careful clinical examination for diagnosis and thus, avoid potentially dangerous and distressing symptoms. The patient improved with a surgical AV fistula ligation. PMID:20142929

George, P.; Jhawar, M. S.; Pawar, B.; Joseph, A.; George, U.

2008-01-01

419

Intestinal anisakiasis treated successfully with conservative therapy: Importance of clinical diagnosis  

PubMed Central

Intestinal anisakiasis is not only a rare parasitic disease, but is also difficult to diagnose. The symptoms are not specific and are often very severe and abrupt, and the findings of clinical imaging are very remarkable. Therefore, intestinal anisakiasis is often misdiagnosed as acute abdomen or intestinal obstruction and is treated surgically. However, if intestinal anisakiasis could be diagnosed correctly, it is well treated conservatively. We experienced three cases of intestinal anisakiasis, which were diagnosed correctly and treated successfully with conservative therapy. A correct clinical history and imaging interpretation helped us diagnose intestinal anisakiasis correctly and thus treat the patients successfully with conservative therapy. PMID:24574731

Shrestha, Santosh; Kisino, Akiko; Watanabe, Makoto; Itsukaichi, Hiroshi; Hamasuna, Kazumitsu; Ohno, Giichiro; Tsugu, Atsushi

2014-01-01

420

Neurosyphilis with psychotic symptoms and Parkinsonism in a young girl  

PubMed Central

A 15-year-old girl with neurosyphilis was misdiagnosed as having viral encephalitis with psychotic symptoms and Parkinsonism. We found that she was experiencing visual hallucinations, persecutory delusions, flattening of affect, poorness of thought, tremors, four-limb rigidity, and restlessness, and she was unable to communicate with others. The Venereal Disease Research Laboratory serum test and further lumbar puncture enabled us to diagnose her with neurosyphilis. After antibiotic treatment, her psychotic symptoms and Parkinsonism were relieved. From this case, we believe that it is important to keep organic psychosis in mind during the diagnostic workup, and we argue that routine syphilis screening is necessary in psychiatry clinical practice. PMID:25733837

Yin, Li; Zou, Shoukang; Huang, Yi

2015-01-01

421

Tinnitus 3 years after strangulation.  

PubMed

Because psychogenic tinnitus can be a presentation of a wide range of psychiatric diseases such as anxiety disorders, somatoform and mood disorders, and personality disorders, the presence of tinnitus in the patient in this case can be easily misdiagnosed as her coexisting major depressive disorder. If brain imaging had been the only modality used, this case patient's cervical dissecting pseudoaneurysm would have been overlooked. Examination of carotid pulses and detection of carotid bruits were crucial parts in the diagnosis of the current patient's pseudoaneurysm. PMID:25629667

YadollahiKhales, Golnaz; Ghorbani, Askar; Borhani-Haghighi, Afshin

2015-02-01

422

Paralysis Episodes in Carbonic Anhydrase II Deficiency.  

PubMed

Carbonic anhydrase II (CAII) deficiency is an autosomal recessive disorder manifest by osteopetrosis, renal tubular acidosis, and cerebral calcification. Other features include growth failure and mental retardation. Complications of the osteopetrosis include frequent bone fractures, cranial nerve compression, and dental mal-occlusion. A hyper-chloremic metabolic acidosis, sometimes with hypokalemia, occurs due to renal tubular acidosis that may be proximal, distal, or more commonly, the combined type. Such patients may present with global hypotonia, muscle weakness or paralysis. We report a case of CA II deficiency with recurrent attacks of acute paralysis which was misdiagnosed initially as Guillian-Barre syndrome. PMID:17657093

Al-Ibrahim, Alia; Al-Harbi, Mosa; Al-Musallam, Sulaiman

2003-01-01

423

Recurrent cutaneous abscesses in two Italian family members  

PubMed Central

Environmental mycobacteria are the causative factors of an increasing number of infections worldwide. Cutaneous infections as a result of such mycobacteria are often misdiagnosed, and their treatment is difficult since they can show in vivo and in vitro multidrug resistance. Absence of pathognomonic clinical signs and variable histological findings often delay diagnosis. We report a case of localized recurrent soft tissue swelling by Mycobacterium marinum in 2 members of the same family. The cases are being reported for their uncommon clinical presentation and the associated etiological agent. Patients recovered completely following therapy with rifampicin 600 mg plus isoniazide 300 mg daily for 45 days. PMID:24470891

Cantisani, Carmen; Richetta, Antonio G.; Bitonti, Andrea; Curatolo, Pietro; Ferretti, Gianfranco; Mattozzi, Carlo; Luca, Melis; Silvestri, Emidio; Calvieri, Stefano

2010-01-01

424

The flexible adult flatfoot: anatomy and pathomechanics.  

PubMed

Adult acquired flatfoot deformity is generally associated with a collapsing medial longitudinal arch and progressive loss of strength of the tibialis posterior tendon. It is most commonly associated with posterior tibial tendon dysfunction that can have an arthritic or traumatic cause. With an increasing population of obese patients, the often misdiagnosed and overlooked posterior tibial tendon dysfunction will only continue to present more often in the foot and ankle specialist's office. This article focuses on the anatomy, classification, and pathomechanics of the flexible adult flatfoot. PMID:24980923

Walters, Jeremy L; Mendicino, Samuel S

2014-07-01

425

Location of recurrent asymptomatic ovarian cancer through endoscopic ultrasound  

PubMed Central

Ovarian cancer is frequent and recurrence happens in about 75% of patients. As it presents high rates of relapse, the exams for this diagnosis are widely discussed. Beside this, there have been discussions about benefits for early anatomic diagnosis and whether endoscopic ultrasound (EUS) can be used to track the relapse of the disease. We present a case, in which anatomic location and histological definition of an asymptomatic recurrence of the ovarian cancer was misdiagnosed with conventional methods, but was possible through EUS. PMID:25789287

Carvalho, Joaquim; Formighieri, Beatriz; Filippi, Sheila; Rossini, Lucio

2015-01-01

426

Disseminated alveolar hydatid disease resembling a metastatic malignancy: a diagnostic challenge-a report of two cases.  

PubMed

Alveolar hydatid disease or alveolar echinococcosis is a disease of the parasite Echinococcus multilocularis that is potentially fatal if left untreated. It primarily involves the liver but can be disseminated to other organs like the lungs and the brain by hematogenous route. Multiorgan involvement and the aggressive appearance of lesions make alveolar hydatid disease easy to confuse with a metastatic malignancy. For this reason, histopathological confirmation is essential for definite diagnosis. We present the imaging features of this disease in two patients in order to emphasize that these lesions can be easily misdiagnosed as malignancies. PMID:25374743

Bulakci, Mesut; Yilmaz, Erdem; Cengel, Ferhat; Gocmez, Ahmet; Kartal, Merve Gulbiz; Isik, Emine Goknur; Celenk, Erhan; Yegen, Gulcin; Salmaslioglu, Artur

2014-01-01

427

Diagnosis and treatment of extra-adrenal pheochromocytoma of urinary bladder: case report and literature review  

PubMed Central

Pheochromocytoma of the urinary bladder is often misdiagnosed as it is a rare tumor. In this report, we described a case with primary pheochromocytoma of the urinary bladder. We specifically conversed the diagnostic role of X-ray computed tomography and sonography to identify the location of tumor within urinary bladder compared to other malignant or benign tumors in the bladder, and exclude other ectopic pheochromocytoma. Histopathological report from bladder tissue biopsy was confirmative of extra adrenal pheochromocytoma of the urinary bladder finally. Importance in careful management of hypertensive crisis during cystoscope and partial cystectomy was addressed. PMID:24179580

Li, Wei; Yang, Bin; Che, Jian-Ping; Yan, Yang; Liu, Min; Li, Qian-Yu; Zhang, Yuan-Yuan; Zheng, Jun-Hua

2013-01-01

428

Isoniazid induced childhood diabetes: A rare phenomenon  

PubMed Central

Drugs raise blood glucose concentrations via two broad mechanisms: By reducing insulin biosynthesis or secretion, or by reducing tissue sensitivity to insulin. Until date, there have been very few reported cases of isoniazid induced diabetes. We are presenting a case report of 6-year-old child with isoniazid induced diabetes who was misdiagnosed initially as a case of type 1 diabetes mellitus. We hereby stress that before diagnosing a patient with diabetes-type 1 or 2, a detailed history of drug intake for any such drugs, which can cause hyperglycemia has to be taken. Clear cut knowledge/cognizance of all such culprit drugs is therefore required.

Manish, Gutch; Keshav, Gupta Kumar; Syed, Razi Mohd; Sukriti, Kumar; Abhinav, Gupta

2015-01-01

429

Congenital ureteric strictures: an uncommon cause of antenatally detected hydronephrosis.  

PubMed

Often misdiagnosed as primary megaureter or pelviureteric junction obstruction, congenital ureteral stenosis and valves are the main causes of congenital ureteric obstruction. We report three consecutive cases of congenital ureteric strictures presenting with antenatally diagnosed hydronephrosis. Two of our cases had a contralateral multicystic dysplastic kidney. We discuss the aetiology, clinical presentation, diagnostic evaluation, surgical management, and operative results as well as present an overview of the international literature, highlighting the importance of early referral in cases of contralateral abnormality as well as the importance of performing a retrograde study to facilitate the diagnosis and choice of incision. PMID:15965693

Cauchi, John A; Chandran, Harish

2005-07-01

430

Retained Intra- Thoracic Surgical Pack Mimicking as Recurrent Aspergilloma  

PubMed Central

An intrathoracic gossypiboma is a rare condition. We are reporting a case of intrathoracicgossypiboma which was misdiagnosed as a recurrent aspergilloma. In our patient, the gossypiboma manifested as a pleural- based extra pulmonary mass which had a large contact area with the pleura and it displayed an extra pulmonary location. A retained surgical swab (gossypiboma) is a rare but an important complication of an intra- thoracic surgery. The diagnosis is usually overlooked, as in our case, resulting in delay of treatment, complications and a prolonged hospitalization. PMID:23373051

Mir, Ruquaya; Singh, Vikram P.

2012-01-01

431

Post-aural Nodular Fasciitis  

PubMed Central

Nodular fasciitis is a rare benign lesion. Here we report a case of post-auricular nodular fasciitis, which was misdiagnosed by fine-needle aspiration cytology (FNAC) as pleomorphic adenoma. An 18-year-old male presented at Al-Nahdha Hospital, physical examination revealed a right post aural firm immobile mass. Radiology suggested the presence of a hypo-dense to iso-dense subcutaneous mass. The swelling was excised and sent for histopathological examination which suggested the diagnosis of nodular fasciitis. FNAC reported pleomorphic adenoma of unusual location should raise the suspicion of nodular fasciitis.

Al Rahbi, Mohammed; Al-Kindi, Hunaina; Al-Sheibani, Salma

2015-01-01

432

Ofloxacin-induced hallucinations  

PubMed Central

Drug-induced hallucinations are not uncommon, and may be misdiagnosed as psychiatric illness leading to unnecessary treatment with antipsychotics. If a temporal association of use of a drug having the potential to cause hallucinations is present, mere withdrawal of the drug causes complete improvement in the symptoms. There are reports of various untoward central nervous system adverse events following administration of fluoroquinolones, including delirium, hallucinations and psychosis, even after a single dose. We describe a 5-year-old girl who suffered visual hallucinations following ofloxacin use. PMID:23716899

Chauhan, Urmila; Shanbag, Preeti; Kashid, Prafull

2013-01-01

433

Cutaneous Adverse Reactions of Amiodarone  

PubMed Central

Dermatological complications of amiodarone are commonly encountered problems in therapy. The incidence in the population of patients with prolonged use of amiodarone reaches nearly 75% according to various sources. Nevertheless, they are often misdiagnosed or overlooked. The aim of this review is to present the current state of knowledge about skin changes induced by amiodarone, including phototoxic and photoallergic reactions, as well as hyperpigmentation. In most cases, the adverse effects are reversible and disappear after discontinuation of the drug. Although the dermatological complications usually do not influence the outcome of the therapy and rarely cause discontinuation of treatment, they have a great impact on patient quality of life. PMID:25413691

Jaworski, Krzysztof; Walecka, Irena; Rudnicka, Lidia; Gnatowski, Maciej; Kosior, Dariusz A.

2014-01-01

434

Delayed traumatic diaphragmatic hernia mimicking hydropneumothorax  

PubMed Central

Traumatic diaphragmatic hernia (TDH) is generally a consequence of thoraco-abdominal trauma. Anaesthetic problems arise due to herniation of abdominal contents into the thoracic cavity causing diaphragmatic dysfunction, lung collapse, mediastinal shift and haemodynamic instability. Diagnosis depends on history, clinical signs and radiological investigations. Sometimes, it may be misdiagnosed as hydropneumothorax due to the presence of air and fluid in the viscera lying in the pleural cavity. We report a case of TDH mimicking hydropneumothorax on radiological investigations and subsequent surgical management, which led to serious complications. PMID:24963185

Wadhwa, Rachna; Ahmad, Zainab; Kumar, Mahendra

2014-01-01

435

Hypertrophic Nonunion Humerus Mimicking an Enchondroma  

PubMed Central

Introduction. Although fractures of humeral shaft show excellent results with conservative management, nonunion does occur. Case Report. We bring forth the case of a young male with a 1.5-year-old hypertrophic nonunion of the humerus mimicking an enchondroma. The initial X-ray images of the patient appeared to be an enchondroma, which only on further evaluation and histopathological analysis was diagnosed conclusively to be a hypertrophic nonunion. Discussion. Enchondromas are often incidentally diagnosed benign tumours. It is however not common to misdiagnose a hypertrophic nonunion to be an enchondroma. We present this case to highlight the unique diagnostic dilemma the treating team had to face. PMID:25525539

Magu, N. K.; Singh, Amanpreet; Wadhwani, Jitendra; Arora, Sahil; Mukhopadhyay Chatterjee, Pragnashree

2014-01-01

436

Diagnosis and classification of Addison's disease (autoimmune adrenalitis).  

PubMed

Autoimmune adrenalitis, or autoimmune Addison disease (AAD), is the most prevalent cause of primary adrenal insufficiency in the developed world. AAD is rare and can easily be misdiagnosed as other conditions. The diagnosis depends on demonstrating inappropriately low cortisol production and the presence of high titers of adrenal cortex autoantibodies (ACAs), along with excluding other causes of adrenal failure using other tests as necessary. The treatment corticosteroid replacement, and the prognosis following the treatment is the same as the normal population. Spontaneous recovery of adrenal function has been described but is rare. PMID:24424183

Brandăo Neto, Rodrigo Antonio; de Carvalho, Jozélio Freire

2014-01-01

437

Malaria or flu? A case report of misdiagnosis  

PubMed Central

We present and discuss elaborately a case of malaria misdiagnosis in a 27-year-old woman in Chalus, Mazandaran Province, North Iran in 2013. The patient has been complaining of fever, shivering and myalgia for three months. Although she visited two physicians during this time, the problem still remained owing to misdiagnose. Eventually in hospital after a precise examination on her thick and thin blood film, the causative agent of disease was diagnosed as plasmodium vivax. The patient received treatment accordingly and all clinical manifestations were vanished. PMID:25183146

Mahdavi, Seif Ali; Raeesi, Ahmad; Faraji, Leyla; Youssefi, Mohammad Reza; Rahimi, Mohammad Taghi

2014-01-01

438

Systemic loxoscelism in the age of community-acquired methicillin-resistant Staphylococcus aureus.  

PubMed

The increase in cases of community-acquired methicillin-resistant Staphylococcus aureus (MRSA), as well as its isolation from the majority of skin and soft tissue abscesses in the emergency department, requires the emergency physician to consider this diagnosis in all skin or soft tissue infections. However, making the diagnosis of MRSA when the wound is actually a cutaneous lesion of a brown recluse spider bite may have untoward consequences. Furthermore, the clinical manifestations of systemic loxoscelism may be misdiagnosed as a systemic staphylococcal infection. We present a patient with systemic loxoscelism who was diagnosed with a systemic infection and received an unnecessary surgical procedure. PMID:20817348

Rogers, Karen M; Klotz, Carrie R; Jack, Meg; Seger, Donna

2011-02-01

439

Unveiling the mystery about adult ADHD: one woman's journey.  

PubMed

Attention deficit hyperactivity disorder (ADHD), a neurobiological disorder, affects millions of individuals and can significantly impact an individual's life course. Research guidelines used in assessment, diagnosis, and treatment have focused primarily on Caucasian males generating, in part, the need to redress how gender and other contextual factors are considered. Consequently many women and persons from diverse cultural groups can be ignored or misdiagnosed. Undiagnosed and untreated women with ADHD are therefore limited in their potential to flourish socially, academically, interpersonally, and in their family roles. This case example of a 38-year-old African American woman illustrates how her life journey was affected by undiagnosed ADHD. PMID:19657868

Waite, Roberta; Ivey, Nicole

2009-09-01

440

A rare case of an aggressive osteoblastoma of the squamous temporal bone: a unique presentation with literature review.  

PubMed

Aggressive osteoblastoma is a rare osteoid tissue forming tumour commonly affecting the spine with predilection for the posterior elements. Calvarial involvement is extremely rare with only two reported cases in the literature. Due to its overlapping clinical, radiographic and histological features with ossifying fibroma, benign osteoblastoma and osteosarcoma, it is very difficult accurately to diagnose this lesion at an early stage. A rare case of an aggressive osteoblastoma of the squamous temporal bone in a young male is presented here which was misdiagnosed twice before reaching the final diagnosis by correlating clinical, radiographic and histopathological features. PMID:24746161

Mohanty, Sujata; Rani, Amita; Urs, A B; Dabas, Jitender

2014-10-01

441

Paradoxical vocal cord motion disorder: past, present and future  

PubMed Central

Paradoxical vocal cord motion disorder (PVCM), also called vocal cord dysfunction, is an important differential diagnosis for asthma. The disorder is often misdiagnosed as asthma leading to unnecessary drug use, very high medical utilisation and occasionally tracheal intubation or tracheostomy. Laryngoscopy is the gold standard for diagnosis of PVCM. Speech therapy and psychotherapy are considered the cornerstone of management of this disorder. The aim of this article is to increase the awareness of PVCM among doctors, highlighting the main characteristics that distinguish it from asthma and discuss the recent medical achievements and the possible future perspectives related to this disorder. PMID:17344570

Ibrahim, Wanis H; Gheriani, Heitham A; Almohamed, Ahmed A; Raza, Tasleem

2007-01-01

442

Diabetic Ankle Fractures: A Review of the Literature and an Introduction to the Adelaide Fracture in the Diabetic Ankle Algorithm and Score  

PubMed Central

Diabetics who have acquired an ankle fracture may be easily missed given their atypical presentation. As such, it is not infrequently seen that these patients are either initially misdiagnosed or ineffectively managed resulting in unnecessary hospital length of stay and procedures. Multiple review articles and retrospective studies have been previously published in the literature, but complete guidelines to assist in accurate diagnosis and cost-effective management for this complex problem do not currently exist. Through a critical analysis of the current literature, a proposed diagnostic and management algorithm and scoring system that can be used to quantify risks in the surgical management are presented for consideration. PMID:24719845

Yee, Joshua; Pillai, Anand; Ferris, Linda

2014-01-01

443

Two rare cases of rhinosporidiosis of parotid duct: Case reports and review of literature  

PubMed Central

Rhinosporidiosis is a chronic granulomatous infective disease caused by fungi, Rhinosporidium seeberi. It can occur universally, is endemic in India, Sri Lanka and in South Asia, mainly reported from Southern India and Sri Lanka. Rhinosporidiosis is a chronic disease classically involving nose and nasopharynx and presents as a localized polypoid mass. Rhinosporidiosis involving parotid duct is rare. We encountered two cases of rhinosporidiosis at extremely unusual extranasal site-parotid duct, presenting as a cyst without nasal manifestations, which was misdiagnosed clinically and on cytological examination. PMID:25593884

Mohapatra, Mounabati; Banushree, C. S.

2014-01-01

444

Intraperitoneal Follicular Dendritic Cell Sarcoma: Role of Chemotherapy and Bone Marrow Allotransplantation in Locally Advanced Disease?  

PubMed Central

We describe a case of a 44 year-old woman diagnosed with follicular dendritic cell sarcoma (FDCS). FDCS is a very rare disease affecting the dendritic antigen presenting cells and is often misdiagnosed. Surgery is considered the best treatment modality, followed by chemotherapy. In our case, surgical excision was not possible, therefore the patient received two lines of chemotherapy followed by bone marrow allotransplantation, then a third line of chemotherapy with a complete metabolic response seen on PET/computed tomography (CT) follow-up 29 months later. A review of the literature has been performed. PMID:25698886

Liberale, G; Keriakos, K; Azerad, MA; De Saint Aubain, N; El Nakadi, I

2015-01-01

445

Catastrophic Intramedullary Abscess Caused by a Missed Congenital Dermal Sinus  

PubMed Central

Congenital dermal sinus (CDS) is a type of occult spinal dysraphism characterized by a midline skin dimple. A 12-month-old girl presented with fever and ascending quadriparesis. She had a midline skin dimple in the upper sacral area that had been discovered in her neonatal period. Imaging studies revealed a holocord intramedullary abscess and CDS. Overlooking CDS or misdiagnosing it as benign sacrococcygeal dimple may lead to catastrophic infection and cause serious neurological deficits. Therefore, further imaging work-up or consultation with a pediatric neurosurgeon is recommended following discovery of any atypical-looking dimples in the midline.

Dho, Yun-Sik; Kim, Seung-Ki; Wang, Kyu-Chang

2015-01-01

446

Clinico-radiologic findings in primary cutaneous extranodal natural killer/t-cell lymphoma, nasal type mimicking cellulitis of the left arm.  

PubMed

Extranodal natural killer (NK)/T-cell lymphoma is a very rare and aggressive disease characterized histopathologically by an Epstein-Barr virus (EBV)-positive atypical lymphoid cytotoxic infiltrate, extensive vascular destruction, and prominent tissue necrosis. It commonly shows cutaneous lesions that primarily or secondarily mimic cellulitis at the primary site. We report on a very rare case of extranodal NK/T-cell lymphoma, nasal type of skin/soft tissue, in a 64-year-old man, and describe the radiological findings. The condition was misdiagnosed as cellulitis of the left arm based on initial noninvasive clinical and radiologic work-up. PMID:25793085

Kim, Soo Hyun; Seon, Hyun Ju; Choi, Yoo Duk; Yun, Sook Jung

2015-01-01

447

Clinico-Radiologic Findings in Primary Cutaneous Extranodal Natural Killer/T-Cell Lymphoma, Nasal Type Mimicking Cellulitis of the Left Arm  

PubMed Central

Extranodal natural killer (NK)/T-cell lymphoma is a very rare and aggressive disease characterized histopathologically by an Epstein-Barr virus (EBV)-positive atypical lymphoid cytotoxic infiltrate, extensive vascular destruction, and prominent tissue necrosis. It commonly shows cutaneous lesions that primarily or secondarily mimic cellulitis at the primary site. We report on a very rare case of extranodal NK/T-cell lymphoma, nasal type of skin/soft tissue, in a 64-year-old man, and describe the radiological findings. The condition was misdiagnosed as cellulitis of the left arm based on initial noninvasive clinical and radiologic work-up. PMID:25793085

Kim, Soo Hyun; Seon, Hyun Ju; Choi, Yoo Duk; Yun, Sook Jung

2015-01-01

448

Small intestine metastasis from cervical cancer with acute abdomen: A case report.  

PubMed

Cervical cancer metastasis to the small intestine is a rare occurrence that is easily misdiagnosed as a small bowel obstruction. The present study reports the case of a 46-year-old cervical cancer patient with metastasis to the small intestine, which presented as an acute abdomen due to intestinal obstruction. Enteroscopy revealed no primary intestinal tumors. The patient underwent exploratory laparotomy and resection of the tumor of the small intestine. Pathology revealed the mass to be squamous cell carcinoma, limited to the outer muscular layer and serosa. This case demonstrates that small intestine seeding must be considered in the differential diagnosis of acute abdomen in patients with cervical cancer. PMID:25435956

Qiu, Hui; Yuan, Limei; Ou, Yangwen; Zhu, Yan; Xie, Conghua; Zhang, Gong

2015-01-01

449

Benign paroxysmal vertigo of childhood: A review of the literature  

PubMed Central

Childrens’ complaints of headache and dizziness merit careful evaluation to differentially diagnose a vestibular disorder. Children can manifest with a syndrome mimicking certain classic signs and symptoms of adult vestibular disorders, such as benign paroxysmal positional vertigo, usually associated with aging. Benign paroxysmal vertigo of childhood in which migraine is a key manifestation along with sudden onset of dizziness, is a rare peripheral vestibular disorder in children that is commonly overlooked or misdiagnosed. This review covers the historical development of the diagnosis, evaluation and treatment approaches of benign paroxysmal vertigo of childhood. PMID:19654978

Batson, Glenna

2004-01-01

450

Langerhans cell histiocytosis presenting as hypothyroid goitre: a unique presentation.  

PubMed

Langerhans cell histiocytosis (LCH) is a disease involving the antigen presenting cells, which can range from a single system involvement with an indolent course to a multisystem disease with increased morbidity. We present a rare case of LCH presenting as hypothyroid goitre that was successfully treated as per the LCH III trial protocol with a combination of vinblastine and oral prednisolone. We highlight the need for awareness of this rare presentation of LCH as a painless goitre which is often misdiagnosed as poorly differentiated thyroid carcinoma or overlooked as a benign disease. PMID:25465459

Marupudi, Krishna Chaitanya; Karanth, Suman S; Thomas, Joseph

2014-01-01

451

Misdiagnosis of abdominal pain in pregnancy: acute pancreatitis.  

PubMed

We report a case of acute pancreatitis in a pregnant woman who presented to our emergency department with complaints of severe abdominal pain, was misdiagnosed as scar dehiscence and underwent emergency repeat caesarean section at 33 wks for fetal distress. The preterm baby developed severe respiratory distress and succumbed on the second postnatal day. Persistent severe pain in the postoperative period in the mother prompted further evaluation which led to a diagnosis of acute pancreatitis. Conservative and supportive management was instituted leading to an eventual favourable maternal outcome. PMID:25738042

Pallavee, P; Samal, Sunita; Gupta, Shweta; Begum, Jasmina; Ghose, Seetesh

2015-01-01

452

Rosette forming glioneuronal tumor of the fourth ventricle in squash cytology smear.  

PubMed

Rosette forming glioneuronal tumor (RGNT) is a recently recognized and extremely rare glioneuronal tumor occurring in the fourth ventricle. It is crucial for the cytopathologist to be aware of this entity as it can be easily mistaken for more common neoplasms occurring at this site. We present here the cytology of such a rare case of RGNT that was misdiagnosed as ependymoma. The varying cytological features of this entity, as well as the common diagnostic difficulties encountered in cytology, are highlighted in this report. PMID:25745291

Nair, Amita Radhakrishnan; Gopalakrishnan, Chittoor Viswanathan; Kapilamoorthy, Tirur Raman; Radhakrishnan, Neelima

2014-01-01

453

Inspiratory stridor and dysphagia in two newborn infants caused by ectopic thymus tissue.  

PubMed

We report two cases of ectopic cervical thymus, a solid thymic lesion, and a thymus cyst causing inspiratory stridor and mild dysphagia in the neonatal period. Because of the rarity of thymic dystopia, the two masses were initially misdiagnosed as more common entities, namely, lymph node enlargement and lymphangioma, respectively. The correct diagnosis was made only after surgical excision and histopathological examination. This case report is completed by a short review of embryogenic development, diagnostic procedures with differential diagnoses, and therapeutic outcome of ectopic thymus. PMID:19104836

Felgentreff, K; Schupp, W; Otten, J E; Rückauer, K D; Uhl, M; Jüttner, E; Superti-Furga, A; Pohl, M

2009-09-01

454

Amyand's hernia.  

PubMed

Acute appendicitis in an incarcerated inguinal hernia is termed an Amyand's hernia. This is an extremely rare condition. It is often misdiagnosed as a strangulated inguinal hernia. The clinical presentation varies, depending on the extent of inflammation in the hernia sac and the presence or absence of peritoneal contamination. We report a case of Amyand's hernia in a 2 year old boy who presented with shock. The basic principle in our management was to stick to the principles of resuscitation and stabilisation of the patient completely before surgery, which lead to a very successful outcome. Emphasis is given to the rarity of the disease and to the review of the literature. PMID:19802555

Bhide, Sunil S

2009-08-01

455

Abdominal scar endometriosis after caesarean section: report of five cases.  

PubMed

Scar endometriosis is an under-appreciated or misdiagnosed phenomenon in general surgery and may eventually be more common than reflected in the literature. We herein report five cases of scar endometriosis that were treated in our surgical department one to five years after Caesarean section. Scar endometriosis should be considered when the symptoms are present in a cyclic manner mostly after gynaecological operations and worsening during menstruation. Diagnosis is mainly based upon a high index ofsuspicion. The treatment of choice is surgical resection. PMID:22224353

Pikoulis, E; Karavokiros, J; Veltsista, K; Diamantis, T; Griniatsos, J; Basios, N; Avgerinos, E; Marinos, G; Kaliakmanis, V

2011-06-01

456

Idiopathic chondrolysis of the hip: case report with a review of the literature.  

PubMed

The first case of idiopathic chondrolysis of the hip from South-East Asia is reported, with a review of the literature. The problems of differential diagnosis are discussed. As the condition is rare, it is likely to be misdiagnosed and may well be over-treated. The rarity of the condition and its natural history terminating in spontaneous fusion make it mandatory that a correct preoperative diagnosis be established in order to avoid needless radical surgery. Some of the significant clinicopathological findings are highlighted. PMID:267469

Sivanantham, M; Kutty, M K

1977-04-01

457

Periorbital necrotising fasciitis: delay in diagnosis results in loss of lower eyelid.  

PubMed

Necrotising fasciitis (NF) is an extremely rare skin and soft tissue infection with extensive necrosis of the subcutaneous tissue and underlying fascia, which usually affects the limbs and trunk. It rarely affects the head and neck region because of the excellent blood supply in this region. We report a case of NF initially misdiagnosed as a traumatic pre-septal cellulitis following self-puncture of a hordeolum externum (stye) and its resistance to aggressive antibiotic therapy resulting in the loss of the lower eyelid. PMID:17593324

Raja, Vignesh; Job, Raly; Hubbard, Alan; Moriarty, Brendan

2008-02-01

458

True vertical tooth root fracture: Case report and review  

PubMed Central

It is important for the clinician not only to gather as much information about a case as possible, but also to be able to correctly interpret the data to arrive at an accurate diagnosis. Occasionally, a case presents with symptoms that might be suggestive of a condition; however, the final diagnosis may be totally different. This paper reports on an interesting case of a true vertical root fracture, in an intact maxillary molar in a 55-year-old man. The case was misdiagnosed and treated as a periodontal defect for over two months. The paper discusses the various causes and diagnostic dilemmas of root fractures. PMID:22090779

Bhaskar, U.; Logani, A.; Shah, Naseem

2011-01-01

459

Stiff Man Syndrome: A Diagnostic Dilemma in a Young Female with Diabetes Mellitus and Thyroiditis  

PubMed Central

Stiff Person Syndrome (SPS), is a very rare neuroimmunologic disorder characterized by progressive muscle pain, rigidity, stiffness, and spasms. It can be very debilitating if misdiagnosed or not recognized in time. Herein we discuss a case of a female in her 20s who presented with an unsteady gait, lower extremity weakness, persistent leg pain, and stiffness few weeks after uncomplicated childbirth. She has type 1 diabetes mellitus (DM) and was diagnosed with thyroiditis in the course of her illness. The triad of thyroiditis, DM, and stiffness with normal neuroimaging in a young female patient is an unusual occurrence. PMID:25525403

Enuh, Hilary; Park, Michael; Ghodasara, Arjun; Arsura, Edward; Nfonoyim, Jay

2014-01-01

460

What is Susac syndrome? - A brief review of articles  

PubMed Central

Susac’s syndrome (SS) is a clinical triad of encephalopathy, branch retinal artery occlusion and sensorineural hearing loss and maybe due to an immune-mediated endotheliopathy. Because of its rarity and some similarities to other common neurological conditions such as multiple sclerosis and acute disseminated encephalomyelitis, it is often misdiagnosed and therefore mistreated. To the best of our knowledge, there is only one case report from our country with this diagnosis. Here, we have a short discussion on this issue to introduce it to our colleagues and remind it as a differential diagnosis in patients with unexplained encephalopathy. PMID:25632332

Nazari, Ferdos; Azimi, Amirreza; Abdi, Siamak

2014-01-01

461

Clinical and Radiologic Review of Uncommon Cause of Profound Iron Deficiency Anemia: Median Arcuate Ligament Syndrome  

PubMed Central

Median arcuate ligament syndrome is an anatomic and clinical entity characterized by dynamic compression of the proximal celiac artery by the median arcuate ligament, which leads to postprandial epigastric pain, vomiting, and weight loss. These symptoms are usually nonspecific and are easily misdiagnosed as functional dyspepsia, peptic ulcer disease, or gastropathy. In this report, we presented a 72-year-old male patient with celiac artery compression syndrome causing recurrent abdominal pain associated with gastric ulcer and iron deficiency anemia. This association is relatively uncommon and therefore not well determined. In addition, we reported the CT angiography findings and three-dimensional reconstructions of this rare case. PMID:25053902

Asil, K?yasettin; Aksoy, Yakup Ersel; Tatl? Ayhan, Laçin

2014-01-01

462

Imitators of exercise-induced bronchoconstriction  

PubMed Central

Exercise-induced bronchoconstriction (EIB) is described by transient narrowing of the airways after exercise. It occurs in approximately 10% of the general population, while athletes may show a higher prevalence, especially in cold weather and ice rink athletes. Diagnosis of EIB is often made on the basis of self-reported symptoms without objective lung function tests, however, the presence of EIB can not be accurately determined on the basis of symptoms and may be under-, over-, or misdiagnosed. The goal of this review is to describe other clinical entities that mimic asthma or EIB symptoms and can be confused with EIB. PMID:20016690

2009-01-01

463

Cutaneous adverse reactions of amiodarone.  

PubMed

Dermatological complications of amiodarone are commonly encountered problems in therapy. The incidence in the population of patients with prolonged use of amiodarone reaches nearly 75% according to various sources. Nevertheless, they are often misdiagnosed or overlooked. The aim of this review is to present the current state of knowledge about skin changes induced by amiodarone, including phototoxic and photoallergic reactions, as well as hyperpigmentation. In most cases, the adverse effects are reversible and disappear after discontinuation of the drug. Although the dermatological complications usually do not influence the outcome of the therapy and rarely cause discontinuation of treatment, they have a great impact on patient quality of life. PMID:25413691

Jaworski, Krzysztof; Walecka, Irena; Rudnicka, Lidia; Gnatowski, Maciej; Kosior, Dariusz A

2014-01-01

464

Amyand’s Hernia: Case Report -Current Dilemma in Diagnosis and Management  

PubMed Central

Amyand’s hernia is an extremely rare condition, often misdiagnosed as a strangulated inguinal hernia, in which the inguinal hernial sac contains the vermiform appendix. It is often a surgical surprise. The reported incidence is approximately 1% of all adult inguinal hernia cases. Acute appendicitis in the Amyand’s hernia is even less common. We report a rare presentation of acute appendicitis associated with Amyand’s hernia managed by en masse reduction of the hernia followed by laparoscopic appendicectomy and open Lichtenstein’s tension free inguinal hernioplasty.

Samuel, Vasanth Mark; Kodiatte, Thomas; Gaikwad, Pranay

2015-01-01

465

Development of the cubic least squares mapping linear-kernel support vector machine classifier for improving the characterization of breast lesions on ultrasound.  

PubMed

An efficient classification algorithm is proposed for characterizing breast lesions. The algorithm is based on the cubic least squares mapping and the linear-kernel support vector machine (SVM(LSM)) classifier. Ultrasound images of 154 confirmed lesions (59 benign and 52 malignant solid masses, 7 simple cysts, and 32 complicated cysts) were manually segmented by a physician using a custom developed software. Texture and outline features and the SVM(LSM) algorithm were used to design a hierarchical tree classification system. Classification accuracy was 98.7%, misdiagnosing 1 malignant an 1 benign solid lesions only. This system may be used as a second opinion tool to the radiologists. PMID:15249070

Piliouras, N; Kalatzis, I; Dimitropoulos, N; Cavouras, D

2004-07-01

466

Disseminated Alveolar Hydatid Disease Resembling a Metastatic Malignancy: A Diagnostic Challenge—A Report of Two Cases  

PubMed Central

Alveolar hydatid disease or alveolar echinococcosis is a disease of the parasite Echinococcus multilocularis that is potentially fatal if left untreated. It primarily involves the liver but can be disseminated to other organs like the lungs and the brain by hematogenous route. Multiorgan involvement and the aggressive appearance of lesions make alveolar hydatid disease easy to confuse with a metastatic malignancy. For this reason, histopathological confirmation is essential for definite diagnosis. We present the imaging features of this disease in two patients in order to emphasize that these lesions can be easily misdiagnosed as malignancies. PMID:25374743

Bulakci, Mesut; Cengel, Ferhat; Gocmez, Ahmet; Kartal, Merve Gulbiz; Isik, Emine Goknur; Celenk, Erhan

2014-01-01

467

Maslow's Hierarchy of Needs and the individual with chronic vestibular dysfunction.  

PubMed

Individuals with chronic vestibular dysfunction may have unmet physiological or safety needs on a chronic basis. Their inability to fulfill the basic needs and progress to higher needs can lead to a patient population with many psychosocial problems. Very often such problems are ignored or unrecognized or are misdiagnosed, and treated inappropriately. This disruption in the individual's life can lead to an inability to progress as a human being. Nursing assessment and appropriate interventions should be developed to treat psychosocial problems in this patient population. The nursing profession should serve patients with vestibular dysfunction through direct care, teaching, counseling, support group facilitation, and research into appropriate interventions. PMID:8564758

Haybach, P J

1994-01-01

468

Cutaneous metastasis of micropapillary urothelial carcinoma.  

PubMed

A 59-year-old man presented with persistent skin rash found to be cutaneous metastasis from micropapillary urothelial carcinoma status post right radical nephroureterectomy and adjuvant chemotherapy. The skin metastasis appeared 2 months after postchemotherapy imaging demonstrated complete radiographic response. Cutaneous metastases from primary genitourinary malignancies are very rare clinical entities associated with poor prognosis. Cutaneous metastases do not have distinctive gross appearance and are often misdiagnosed as common dermatologic disorders. It is imperative that urologists have high index of suspicion for metastasis in patients with persistent skin rash in the setting of advanced genitourinary malignancies. PMID:25559725

Truong, Hong; Parsons, Theodore M; Trabulsi, Edouard J

2015-02-01

469

Palinacousis leading to the diagnosis of temporal lobe seizures in a patient with schizophrenia.  

PubMed

Palinacousis is a rarely reported symptom of temporal lobe dysfunction. Especially in psychiatric patients it may be misdiagnosed if it is not differentiated from the auditory hallucinations of psychotic illness. We report the case of a 20-year-old patient with the previously established diagnosis of paranoid schizophrenia who presented with the symptom of palinacousis. She was not psychotic at that time, her only complaints being recurrent auditory sensations. Repeated EEG recordings showed a left temporal theta focus with spikes. The diagnosis of temporal lobe seizures was made. Treatment with carbamazepine led to complete recovery. PMID:12018964

Prueter, Christian; Waberski, Till D; Norra, Christine; Podoll, Klaus

2002-04-01

470

Pulmonary Artery Angiosarcoma Confused with Acute Pulmonary Thromboembolism: Focusing on Clinical and Echocardiographic Features in the Differentiation of Two Categories  

PubMed Central

Although pulmonary artery angiosarcoma is rare, it can be misdiagnosed as pulmonary embolism because of its similar clinical and diagnostic features. The diagnosis is often delayed and the misdiagnosis brings unnecessary treatment. Because we made a wrong diagnosis of pulmonary artery angiosarcoma as an acute pulmonary embolism, we did thrombolytic therapy which could be dangerous to the patient. In this case report, we focused on the clinical and echocardiographic features of pulmonary artery angiosarcoma which can be used in differentiating the diagnosis from pulmonary embolism.

Kim, Mi Joo; Kim, Min Su; Park, Kwang-In; Lee, Choong-Sik; Na, Myung Hoon; Lee, Jae-Hwan; Choi, Si Wan; Jeong, Jin-Ok; Seong, In-Whan

2015-01-01

471

Typical MDCT Angiography Findings of an Unusual Cutaneous Neoplasia; Masson Tumor  

PubMed Central

Summary Background Intravascular papillary endothelial hyperplasia (IPEH), also known as masson tumour, is a lesion composed of proliferating endothelial cells. Case Report In this article we explained clinical, histological and radiological features of IPEH involving the scalp, localized on the left side of the skull and in the periauricular region. Conclusions Radiologically, intravascular papillary endothelial hyperplasia could be misdiagnosed as malignant or benign vascular tumour. On cross-sectional imaging it is useful demonstrating the extremely vascular component of IPEH. But IPEH has no specific radiologic features that we can use to differentiate from the aforementioned lesions. Due to that, histopathological examinations are needed to diagnose IPEH. PMID:25624958

Tutar, Onur; Samanci, Cesur; Bakan, Selim; Alis, Denizcan; Kaur, Ahmet; ?anl?, Deniz Tekcan; Yildirim, Duzgun

2015-01-01

472

Crowned dens syndrome diagnosed on ą?F-FDG PET/CT.  

PubMed

An 87-year-old woman with corticosteroid-resistant polymyalgia rheumatica underwent ą?F-FDG PET/CT for suspected giant cell arteritis or neoplastic disease. FDG uptake in the immediate vicinity of the odontoid process, with a crownlike calcification, was identified on the CT scan on the posterior side of the dens, thus confirming the diagnosis of crowned dens syndrome. Because this rare syndrome is frequently misdiagnosed, nuclear physicians should be aware of the signs and symptoms of this condition, which may call for the use of PET/CT imagery. PMID:25243939

Monet, Antoine; Massonnat, Richard; Merino, Bertrand; Riviere, Annalisa; Richez, Christophe

2014-12-01

473

[Stiff baby syndrome is a rare cause of neonatal hypertonicity.  

PubMed

Stiff baby syndrome (hyperekplexia) is a rare genetic disorder. The condition can easily be misdiagnosed as epilepsy or severe sepsis because of hypertonicity and seizure-like episodes and has an increased risk of severe apnoea and sudden infant death. Tapping of the nasal bridge inducing a startle response is the clinical hallmark. We report cases of two sisters born with stiff baby syndrome with hypertonicity, exaggerated startle reaction and cyanosis. The syndrome has a good prognosis if treated with clonazepam and both cases were developmental normal after one year. PMID:25350416

Rřnne, Maria Sode; Nielsen, Preben Berg; Mogensen, Christian Backer

2014-02-24

474

Acute cervicitis and vulvovaginitis may be associated with Cytomegalovirus  

PubMed Central

Cytomegalovirus (CMV) infection in immunocompetent hosts is generally asymptomatic or may present as a mononucleosic syndrome. Its association with acute cervicitis and vulvovaginitis has rarely been reported. A 24-year-old woman presented with pelvic pain, vulvodynia, abnormal vaginal discharge, burning with urination, fatigue, fever, vomiting and diarrhoea. The vulva and cervix were red with vesicular lesions on the cervix. Genital herpes simplex infection (HSV) was suspected and valacyclovir was given orally. However, serial viral cultures performed 7?weeks apart did not isolate HSV as suspected, but CMV was confirmed by immunofluorescence and early antigen research. Blood tests confirmed an acute CMV infection. Typical inclusions were found at histology. Symptoms resolved slowly with persistence of cervical lesions at 7?weeks from diagnosis. The frequency of CMV genital infection is probably underestimated. The infection is not always asymptomatic and might be confused with genital HSV infection. The clinical course is longer. PMID:23606387

Abou, Magali; Dällenbach, Patrick

2013-01-01

475

Round ligament of uterus leiomyoma: an unusual cause of dyspareunia.  

PubMed

Round ligament of uterus leiomyoma is a rare, benign tumor of the vulva. Its incidence is not known exactly, and the mean age ranges from 13 to 70. Although clinical properties of benign and malignant diseases in the vulvar area are frequently similar, early diagnosis and treatment are essential. Local excision is recommended as definitive therapy. We present an 28-year-old female without any birth with a mass in anterior vaginal wall diagnosed as vulvar leiomyoma. In conclusion, a brief review of relevant literature emphasizes that leiomyomas are quite rare outside of the uterus but they might occur in any tissue or organ containing smooth muscle, spontaneously or parasitically after the spreading effect of an accident or surgical trauma. Clinicians should be alert especially for the diagnosis in a tissue with smooth muscle content. PMID:25834749

Birge, Ozer; Arslan, Deniz; Kinali, Erdinc; Bulut, Berk

2015-01-01

476

A quantitative morphological examination of bovine vulval skin glands.  

PubMed Central

In adult cows the volumes of sweat and sebaceous glands per unit skin surface area (ssa) in the vulva were greater (P less than 0.01) than in the neck, lip or eyelids. Within this perineal region skin gland volumes were greater dorsally than ventrally (P less than 0.01). Adult cows had much greater (P less than 0.01) volumes of perineal skin glands per unit ssa than 8 weeks or 6 weeks old heifer calves or steers. There was little or no difference between animal categories in neck skin gland dimensions. Adult morphology of perineal sebaceous glands was present in 15 and 18 months but not 6 and 9 months old heifer calves. The skin glands of the perineal region in cows should be considered as specialised skin glands. Images Fig. 1 Fig. 2 Fig. 3 PMID:3503046

Blazquez, N B; Batten, E H; Long, S E; Perry, G C

1987-01-01

477

A case of vulvar hematoma with rupture of pseudoaneurysm of pudendal artery.  

PubMed

Vulvar hematomas are uncommon outside of the obstetric population and may be the result of trauma to the perineum. Vulvar hematomas most often present with low abdominal pain and urologic and neurologic symptoms. The vulva has rich vascularization that is supplied by the pudendal artery, a branch of the anterior division of the internal iliac artery. We describe a rare case of a 15-cm-sized vulvar hematoma with the suggested rupture of a pseudoaneurysm of the left pudendal artery without trauma injury. A 14-year-old girl presented with sudden pain and swelling in her left labium and was successfully treated with selective arterial embolization and surgical evacuation. We provide a literature review and discuss patient treatment and management strategies. PMID:24678493

Hong, Hye Ri; Hwang, Kyu Ri; Kim, Sung Ae; Kwon, Jeong Eun; Jeon, Hye Won; Choi, Ji Eun; So, Young Ho

2014-03-01

478

Role of the extracellular matrix in epithelial morphogenesis  

PubMed Central

The extracellular matrix (ECM) plays an essential role in organizing tissues, defining their shapes or in presenting growth factors. Their components have been well described in most species, but our understanding of the mechanisms that control ECM remodeling remains limited. Likewise, how the ECM contributes to cellular mechanical responses has been examined in few cases. Here, I review how studies performed in C. elegans have brought several significant advances on those topics. Focusing only on epithelial cells, I discuss basement membrane invasion by the anchor cell during vulva morphogenesis, a process that has greatly expanded our knowledge of ECM remodeling in vivo. I then discuss the ECM role in a novel mechanotransduction process, whereby muscle contractions stimulate the remodeling of hemidesmosome-like junctions in the epidermis, which highlights that these junctions are mechanosensitive. Finally, I discuss progress in defining the composition and potential roles of the apical ECM covering epidermal cells in embryos. PMID:22692230

Labouesse, Michel

2012-01-01

479

Litomosoides (Nemata: Filarioidea) of bats from Bolivia with records for three known species and the description of a new species.  

PubMed

Herein, we describe Litomosoides salazari n. sp. collected from the body cavity of the yellow bat, Lasiurus ega , from Bolivia. This new species of filarioid nematode is most closely related to the carinii group and is characterized by its relatively small size with the vulva located slightly posterior to the esophago-intestinal junction; an arrow-shaped buccal capsule; and a short, rounded tail. New host and locality records for both Litomosoides hamletti and L. chandleri in phyllostomid bats, and L. brasiliensis occurring in both phyllostomid and vespertilionid bats, are provided. The morphological variability of the specimens is documented by providing comparative measurements of 3 known species. Litomosoides brasiliensis occurs in 6 species of bats from Bolivia and was the most common species of filarioid nematode encountered. All 4 species of nematodes, including the new species, were found in sympatry at Chijchijpa, a locality in the Yungas of Bolivia. PMID:20738202

Notarnicola, Juliana; Ruíz, F Agustín Jiménez; Gardner, Scott L

2010-08-01

480

Two new species and a new record of Comesomatidae (Nematoda, Araeolaimida) from Southern Hikurangi Margin, New Zealand.  

PubMed

We describe two new species and provide one new species record of the family Comesomatidae from a submarine canyon habitat on the Southern Hikurangi margin, New Zealand. Vasostoma hexodontium n. sp. is characterized by having an amphideal fovea with three turns, buccal cavity with six teeth and gubernaculum with long and straight caudal apophyses. Sabatieria dispunctata n. sp. is characterized by the absence of cuticle punctations, large amphideal fovea with 4.5 turns, pharynx with posterior bulb, absence of pre-cloacal supplements, strongly arcuate and cuticularized spicules, simple gubernaculum with short caudal apophyses, and vulva opening directed posteriorly. Laimella subterminata Chen & Vincx, 2000, which was originally described from the Beagle Channel and the Magellan Strait (Chile), is recorded from the Southwest Pacific for the first time.  PMID:25543753

Rosli, Norliana; Leduc, Daniel; Probert, P Keith

2014-01-01

481

A new species of Syphacia (Seuratoxyuris) (Nematoda: Oxyuridae) from Sooretamys angouya Fischer, 1814 (Rodentia: Cricetidae) in Argentina.  

PubMed

Syphacia (Seuratoxyuris) hugoti n. sp. (Nematoda: Oxyuridae) is described from the cecum of Sooretamys angouya (Cricetidae: Sigmodontinae: Oryzomyini) captured in Formosa Province, Argentina. The diagnosis of the subgenus is emended, and the new species is separated from eight congeners by the distribution of submedian papillae and amphids, shape of the cephalic plate, presence of deirids, absence of cervical and lateral alae, length of the spicule, structure of the accessory hook of the gubernaculum and distance of excretory pore and vulva from the anterior extremity. The analysis suggests that S. (Se.) oryzomyos should be removed from Seuratoxyuris and redesignated as S. (Syphacia) oryzomyos n. comb. To date, of the species of Syphacia found in South and North American, 7 parasitize Oryzomyini rodents, of which two are distributed in Argentina. The present study constitutes the first record of the subgenus Seuratoxyuris from Argentina and the third record of a Syphacia species from rodents of the tribe Oryzomyini. PMID:24995650

Robles, María del Rosario; Panisse, Guillermo; Navone, Graciela Teresa

2014-11-01

482

Two new species of Syphacia (Nematoda: Oxyuridae) in endemic murid rodents from Sulawesi, Indonesia.  

PubMed

Two new species of Syphacia (Nematoda: Oxyuridae) are described from endemic murids of Sulawesi, Indonesia: Syphacia (Syphacia) taeromyos sp. n. and S. (S.) paruromyos sp. n. parasitic in the caecum of Taeromys celebensis and Paruromys dominator, respectively. They are readily distinguished from all of the congeners recorded from Indonesia-Australian regions by having a round cephalic plate, vesicular lateral alae in the male, posteriorly positioned excretory pore in the male, and/or lacking cervical alae. Syphacia (S.) paruromyos differs from S. (S.) taeromyos by having a whip-like tail appendage in the male, longer relative distance between excretory pore and vulva, and larger eggs. The round cephalic plate in both sexes and developed vesicular lateral alae in the male are morphological traits common in endemic Syphacia species hitherto known from Sulawesi murids, suggesting that they have derived from a common ancestor and evolved with their hosts in the isolated insular environment. PMID:23110941

Dewi, K; Hasegawa, H

2014-03-01

483

Perianal Paget disease treated definitively with radiotherapy  

PubMed Central

Extramammary Paget disease (empd) is a relatively rare cutaneous disorder described as an apocrine gland tumour occurring in both a benign and a malignant form with metastatic potential. The areas of the body affected are the vulva, perianal region, penis, scrotum, perineum, and axilla, all of which contain apocrine glands. When empd affects the perianal region, it is called perianal Paget disease (ppd). All forms of empd, including ppd, are typically treated by wide surgical excision. Perianal Paget disease usually occurs later in life in patients who are often poor surgical candidates, but the available literature is scarce regarding other treatment modalities, including definitive radiotherapy. We contend that ppd can be safely and effectively treated with radiotherapy, and here, we present the case of a 75-year-old woman with ppd who was successfully so treated. A brief review of the literature concerning the diagnosis, natural history, and treatment of ppd is also included. PMID:23300373

Mann, J.; Lavaf, A.; Tejwani, A.; Ross, P.; Ashamalla, H.

2012-01-01

484

Late injury of cancer therapy on the female reproductive tract  

SciTech Connect

The purpose of this article is to review the late effects of cancer therapy on the female reproductive tract. The anatomic sites detailed are the vulva, vagina, cervix, uterus, fallopian tubes, and ovaries. The available pathophysiology is discussed. Clinical syndromes are presented. Tolerance doses of irradiation for late effects are rarely presented in the literature and are reviewed where available. Management strategies for surgical, radiotherapeutic, and chemotherapeutic late effects are discussed. Endpoints for evaluation of therapeutic late effects have been formulated utilizing the symptons, objective, management, and analytic (SOMA) format. Late effects on the female reproductive tract from cancer therapy should be recognized and managed appropriately. A grading system for these effects is presented. Endpoints for late effects and tolls for the evaluation need to be further developed. 61 refs., 9 figs., 13 tabs.

Grigsby, P.W. [Washington Univ. School of Medicine, St. FLouis, MO (United States)] [Washington Univ. School of Medicine, St. FLouis, MO (United States); Russell, A. [Radiological Associates, Sacramento, CA (United States)] [Radiological Associates, Sacramento, CA (United States); Bruner, D. [Fox Chase Cancer Center, Philadelphia, PA (United States)] [and others] [Fox Chase Cancer Center, Philadelphia, PA (United States); and others

1995-03-30

485

The anesthetic action of ethanol analyzed by genetics in Caenorhabditis elegans  

SciTech Connect

Acute exposure to ethanol causes paralysis at high concentrations in the nematode Caenorhabditis elegans. We set out to elucidate the mechanism of the anesthetic action of ethanol by genetic approaches. We identified nine mutations that conferred reduced sensitivity to ethanol after chemical, irradiation, or transposon insertion mutagenesis. Of these nine, we further characterized five mutations that defined four genes, jud-1-jud-4. Analysis of the phenotypes of the animals heterozygous for two unlinked genes revealed that jud-1 and jud-3 act synergistically in a gene dose-dependent manner. We cloned jud-4 and found that it encodes a protein with limited homology to human Homer proteins. jud-4 was expressed in the hypodermis and vulva muscles, suggesting that this gene acts in tissues directly exposed to the external environment. Characterization of the other mutations identified in this study will facilitate the elucidation of the molecular mechanism for the anesthetic action of ethanol.

Hong, Mingi; Choi, Myung Kyu [Research Center for Functional Cellulomics, Institute of Molecular Biology and Genetics, School of Biological Sciences, Seoul National University, 56-1 Gwanak-gu, Shillim-dong, Seoul 151-742 (Korea, Republic of); Lee, Junho [Research Center for Functional Cellulomics, Institute of Molecular Biology and Genetics, School of Biological Sciences, Seoul National University, 56-1 Gwanak-gu, Shillim-dong, Seoul 151-742 (Korea, Republic of)], E-mail: elegans@snu.ac.kr

2008-02-29

486

The uterine cervix--a new member of the family of immunologically exceptional sites?  

PubMed

As a bystander effect, immune responses against infectious organisms can damage normal cells. Immune privilege can protect such endangered tissues from immune destruction. One example is the eye where potentially devastating inflammatory reactions are prevented by active, counter-regulating processes that prevent lymphocyte activation. Recent epidemiological data from transplant patients in Sweden showed, surprisingly, that the frequency of cervical cancers did not increase in organ transplant recipients, in contrast to cancers of the vagina, vulva and anus. The same subtypes of HPV are known to be involved in the genesis of all these tumors. The immune surveillance mechanisms known to antagonize the outgrowth of virally-associated neoplasms would have been expected to affect them all. The special case of cervical carcinomas may reflect a site-specific immune privilege that could have evolved to protect the integrity of the reproductive function. PMID:12844288

Höglund, Petter; Kärre, Klas; Klein, Georg

2003-07-01

487

[The study on the epidemiological features and risk factor of Chlamydia trachomatis reproductive tract infection (CTRTI) among 664 married women at reproductive age in rural areas].  

PubMed

The infection rate and risk factors of CTRTI among 664 married women at reporductive age in rural areas in Chengjiang county, Yunnan province were investigated. Specimens of cervical swab were detected for CT antigen using Chlamydia EIA(Syva co., USA). The selection of major risk factors was through Logistic regression and chi 2-test. The results showed that the overall infection rate of CTRTI was 5.0%, with 60.6% of these cases asymptomatic. The major risk factors include: spouse who has symptoms of RTIs; history of others vaginitis; divorce; habit of washing face, feet and vulva with the same wash basin; age of menarche; amenorrhoea during lactation; low education and living in poverty. PMID:9812502

Li, W; Huang, X H; Wang, T Y

1997-04-01

488

Acute cervicitis and vulvovaginitis may be associated with Cytomegalovirus.  

PubMed

Cytomegalovirus (CMV) infection in immunocompetent hosts is generally asymptomatic or may present as a mononucleosic syndrome. Its association with acute cervicitis and vulvovaginitis has rarely been reported. A 24-year-old woman presented with pelvic pain, vulvodynia, abnormal vaginal discharge, burning with urination, fatigue, fever, vomiting and diarrhoea. The vulva and cervix were red with vesicular lesions on the cervix. Genital herpes simplex infection (HSV) was suspected and valacyclovir was given orally. However, serial viral cultures performed 7 weeks apart did not isolate HSV as suspected, but CMV was confirmed by immunofluorescence and early antigen research. Blood tests confirmed an acute CMV infection. Typical inclusions were found at histology. Symptoms resolved slowly with persistence of cervical lesions at 7 weeks from diagnosis. The frequency of CMV genital infection is probably underestimated. The infection is not always asymptomatic and might be confused with genital HSV infection. The clinical course is longer. PMID:23606387

Abou, Magali; Dällenbach, Patrick

2013-01-01

489

Round Ligament of Uterus Leiomyoma: An Unusual Cause of Dyspareunia  

PubMed Central

Round ligament of uterus leiomyoma is a rare, benign tumor of the vulva. Its incidence is not known exactly, and the mean age ranges from 13 to 70. Although clinical properties of benign and malignant diseases in the vulvar area are frequently similar, early diagnosis and treatment are essential. Local excision is recommended as definitive therapy. We present an 28-year-old female without any birth with a mass in anterior vaginal wall diagnosed as vulvar leiomyoma. In conclusion, a brief review of relevant literature emphasizes that leiomyomas are quite rare outside of the uterus but they might occur in any tissue or organ containing smooth muscle, spontaneously or parasitically after the spreading effect of an accident or surgical trauma. Clinicians should be alert especially for the diagnosis in a tissue with smooth muscle content. PMID:25834749

Birge, Ozer; Arslan, Deniz; Kinali, Erdinc; Bulut, Berk

2015-01-01

490

Multiple giant vulvar syringoma: an extraordinary report.  

PubMed

A 26 year-old woman presented with asymptomatic multiple skin-colored eruptions affecting the vulva. She claimed that the lesions had started at the age of 15. The eruptions have been increasing in size and extent since her presentation. There was a family history of similar eruptions around the eyes of one of her sisters. Examination of the skin surface was marked by the presence of multiple, 2- to 3-cm firm, skin-colored, nodules on the labia majora (Figure 1). They were bilateral and symmetrical. One of the lesions was excised, and histopathologic serial sections were prepared and stained with hematoxylin and eosin. Sections showed clusters of small comma-shaped ducts lined by 2 cell-thick epithelium surrounded by a fibrotic stroma. Solid strands of basophilic epithelial cells independent of ducts were documented in the dermis (Figure 2). Accordingly, a diagnosis of syrangoma was made. PMID:24340473

Sadeghian, Giti; Ziaei, Hengameh

2013-01-01

491

[Malignant melanoma among the ethnic Melanesian population of New Caledonia].  

PubMed

Melanesian population amounts to 61,270 out of 145,368 inhabitants in New Caledonia according to the last census. Melanesians of phototype VI have no predisposition in regard to malignant melanoma. From 1977 to 1987, 7 cases have been reported. Localisations are always in some zones not exposed to sunlight: 3 acral-lentiginous melanoma of the sole, 2 tumorous nodules of the anus margin and the vulva, 2 choroidal localisations. So, incidence of cutaneous malignant melanoma is very low (0.7/100,000 per annum) and in accordance with classical data regarding black people. But one has to keep in mind its being in some characteristic localisations. All the above referred cases have been detected at an advanced local extension. PMID:2677591

Di Schino, M; Huerre, M; Bobin, P; Chanut, G; Maire, M J; Clerget-Gurnaud, J M; Weiman, D

1989-01-01

492

Description of Thecavermiculatus andinus n.sp. (Meloidoderidae), a Round Cystoid Nematode from the Andes Mountains of Peru  

PubMed Central

Thecavermiculatus andinus n.sp. is described and illustrated from Oxalis tuberosa originally collected in the vicinity of Lake Titicaca high in the Andes mountains of southern Peru. This new species differs markedly front the other two species in the genus, especially in having a much greater female vulval-anal distance and annules with lined punctation on most of the female body with a lacelike pattern restricted to the posterior portion, particularly at the vulva and anus which do not protrude. Females are essentially spherical with protruding neck, white to yellowish in color, and can easily be mistaken for potato cyst nematodes. Among the dozen or more known weed and crop host plants are potato and eggplant. In order to accommodate this new species, the genus Thecavermieulatus is emended. A key to the species of this genus is presented. PMID:19295818

Golden, A. M.; Franco, J.; Jatala, P.; Astogaza, E.

1983-01-01

493

Description of Thecavermiculatus andinus n.sp. (Meloidoderidae), a Round Cystoid Nematode from the Andes Mountains of Peru.  

PubMed

Thecavermiculatus andinus n.sp. is described and illustrated from Oxalis tuberosa originally collected in the vicinity of Lake Titicaca high in the Andes mountains of southern Peru. This new species differs markedly front the other two species in the genus, especially in having a much greater female vulval-anal distance and annules with lined punctation on most of the female body with a lacelike pattern restricted to the posterior portion, particularly at the vulva and anus which do not protrude. Females are essentially spherical with protruding neck, white to yellowish in color, and can easily be mistaken for potato cyst nematodes. Among the dozen or more known weed and crop host plants are potato and eggplant. In order to accommodate this new species, the genus Thecavermieulatus is emended. A key to the species of this genus is presented. PMID:19295818

Golden, A M; Franco, J; Jatala, P; Astogaza, E

1983-07-01

494

Planar polarity genes and inhibition of supernumerary neurites.  

PubMed

Planar cell polarity (PCP) genes have recently emerged as important players in sculpting neuronal connections. The bipolar VC neurons display stereotypical differences in axon extension along the anterior-posterior (AP) body axis: VC1-3 and VC6 polarize along the AP axis while VC4 and VC5 polarize along the orthogonal left-right (LR) axis generated by the developing vulva. vang-1 and prkl-1, the worm orthologs of Van Gogh and Prickle, are required to restrict the polarity of neurite emergence to a specific tissue axis. vang-1 and prkl-1 loss results in ectopic VC4 and VC5 neurites extending inappropriately along the AP axis. Conversely, prkl-1 overexpression in VC neurons suppresses neurite formation. These findings suggest that a PCP-like pathway acts to silence or antagonize neuronal responses to polarity cues that would otherwise be permissive for neurite growth. PMID:24058835

Colavita, Antonio

2012-04-01

495

Myctolaimellus robiniae n. sp. (Diplogasterida: Cylindrocorporidae) from Larval Cavities of the Locust Borer, Megacyllene robiniae Forster  

PubMed Central

A new nematode species of the family Cylindrocorporidae and the genus Myctolaimellus from subcortical cavities made by the locust borer (Megacyllene robiniae Forster) in black locust (Robinia pseudoacacia L.) is described. Males of the new species have a length of 700 to 1,050 µm; a bursate tail, peloderan with nine pairs of rays; and knobbed, curved spicules with tips bending gently into a hook. The distinctive gubernaculum is half the length of the spicules, deeply grooved longitudinally along both its dorsal and ventral surfaces, and has a spoon-shaped end. Females have a length of 830 to 1,340 µm, an amphidelphic reproductive tract with long ovaries crossing each other to extend beyond the equatorial vulva, and a gradually tapering tail. PMID:19270993

Harman, A.; Winter, J.; Harman, D.

2000-01-01

496

A new ladybird spider from Hungary (Araneae, Eresidae)  

PubMed Central

Abstract According to the most recent taxonomic literature, three species of the genus Eresus are known in Central Europe, Eresus kollari, Eresus sandaliatus and Eresus moravicus. We recognized a fourth distinctive species from Hungary, which is described as Eresus hermani sp. n. Eresus hermani has an early spring copulation period, females have a light grey (grizzled) cephalothorax due to a heavy cover of lightly colored setae, and an epigyne with large flat areas posterior to the epigynal pit, while males are distinguished by a broad and blunt terminal tooth of the conductor. An updated and modified comparative table of ?ezá? et al. (2008) to include all four Central European Eresus species, and a simple key to the species group’s species are given. Habitus, epigyne, vulva and conductor of Eresus kollari, Eresus moravicus and Eresus sandaliatus are also illustrated. An annotated list of papers illustrating Eresus hermani due to misidentifications is presented. PMID:25901112

Kovács, Gábor; Prazsák, István; Eichardt, János; Vári, Gábor; Gyurkovics, Henrik

2015-01-01

497

Vaginal Cancer  

Microsoft Academic Search

\\u000a \\u000a \\u000a \\u000a \\u000a • \\u000a \\u000a \\u000a The vagina can be a common site of secondary involvement, either through direct extension from the cervix and vulva or by\\u000a lymphatic and vascular spread.\\u000a \\u000a \\u000a \\u000a \\u000a • \\u000a \\u000a \\u000a Invasive cancers most commonly present with irregular vaginal bleeding or discharge (often postcoital), followed by vaginal\\u000a discharge or dysuria. Vaginal intraepithelial neoplasia (VaIN) is diagnosed on routine screening.\\u000a \\u000a \\u000a \\u000a \\u000a • \\u000a \\u000a \\u000a Diagnostic workup should include

Nitika Thawani; Subhakar Mutyala; Aaron H. Wolfson

498

Swedish Plectida (Nematoda). Part 5. Rhadinema timmi (Vitiello, 1971) comb. n.  

PubMed

Leptolaimus timmi Vitiello, 1971 is redescribed from bottom sediments collected in the Skagerrak off the west coast of Sweden. New morphological data necessitate the transfer of this species to the genus Rhadinema Cobb, 1920. The main diagnostic characters of Rhadinema timmi (Vitiello, 1971) comb. n. include: 1.3-1.8 mm long body; rounded labial region weakly offset from body contour; cephalic setae 2-4 µm long; amphid located 12-19 µm from anterior end; first body pore located 22-30 µm from anterior end; lateral field absent; stoma tubular: cheilostom with six weakly cuticularised longitudinal rugae, gymnostom with sclerotized bar-shaped rhabdia, stegostom long, tubular; female without supplements, vagina without pars refringens, vulva midventral; male with 10-11 tubular and without alveolar supplements; spicules arcuate and 21-30 µm long. PMID:24871742

Holovachov, Oleksandr; Boström, Sven

2014-01-01

499

Three New Species of the Super Family Neotylenchoidea (Nematoda: Tylenchida) from Pakistan  

PubMed Central

Three new species in the super family Neotylenchoidea collected in Pakistan during 1979-80 are described. New species Nothotylenchus gohleni is related to N. affinis Thorne, 1941 but is differentiated by its longer, more robust body with tine cuticular annules, a more posterior vulva, inconspicuous basal knobs of the stylet, and poorly developed metacorpal area. N. geraerti and N. tuberosus are also close to this undescribed species, hut they have a more developed metacorpal area and a larger post uterine sac. Boleodorus zaini n.sp. is distinguished by its excretory pore open at a level with the base of the posterior esophageal bulb and by six distinct lines in the lateral field. Paurodontella sohailai n.sp. is closely related to P. densa (Thorne, 1941) Hussain &Khan, 1967 and P. minuta Hussain &Khan, 1967 but differs from them by its larger body, shape of tail, and seven incisures in the lateral field. PMID:19295714

Maqbool, M. A.

1982-01-01

500

MRI features of cellular angiomyofibroma with pathologic correlation.  

PubMed

Within the spectrum of extratesticular mesenchymal tumors in the scrotum and perineum lies cellular angiofibroma, also known as angiomyofibroblastoma-like tumor, a rare lesion originally described to almost exclusively occur in the vulva, perineum, and pelvis of women. We report a case of this tumor, with an adjacent scrotal lipoma, occurring in a 60-year-old male who presented to our department with a firm palpable scrotal mass. To our knowledge, the MRI findings of this entity have yet to be described in the radiological literature. We present the MRI features of cellular angiofibroma that are consistent with the pathological characteristics of this entity-a benign cellular and fibrous tumor with prominent vascularity. PMID:19388110

Koo, Phillip J; Goykhman, Igor; Lembert, Larissa; Nunes, Linda W

2009-05-01