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1

Sparganosis in mainland China.  

PubMed

Sparganosis is an infection of humans and animals caused by the plerocercoid larvae (spargana) of various diphyllobothroid tapeworms belonging to the genus Spirometra. Sparganosis has been reported sporadically around the world, and a higher prevalence of the disease occurs in several Asian countries, including South Korea, Japan, Thailand, and China. To date, a total of more than 1000 cases of human sparganosis have been reported in 25 provinces in mainland China. Sparganosis is emerging in mainland China because of food consumption habits and the unusual practice of treating wounds or other lesions with poultices of frog or snake flesh. This article reviews the current status of sparganosis in mainland China. Increased public awareness about the risks associated with eating raw food and strengthened food safety measures are needed. PMID:21126898

Li, Ming-Wei; Song, Hui-Qun; Li, Chun; Lin, Hong-Ying; Xie, Wei-Tian; Lin, Rui-Qin; Zhu, Xing-Quan

2010-12-03

2

Pruritus Vulvae  

Microsoft Academic Search

\\u000a Margaret is a 25-year-old solicitor who has been married for 5 years, her husband having been her first and only sexual partner.\\u000a She presents to you as her General Practitioner with a 4-day history of itch in the vulva and a little vaginal discharge.\\u000a Her general health is good and she has not had similar symptoms before. Her last menstrual

Alexander McMillan

3

Disorders of the Vulva  

MedlinePLUS

... disorders can affect the vulva? • What self-care measures can help prevent or clear up vulvar problems? • ... or bumps on the vulva. What self-care measures can help prevent or clear up vulvar problems? ...

4

Vulva Fibroadenoma Associated with Lactating Adenoma in a 26-Year-Old Nigerian Female  

PubMed Central

Background. Vulva lactating adenoma is rare and may be misdiagnosed as adenocarcinoma in frozen section and aspiration cytology if breast tissue is not anticipated. Objective. To raise the awareness of lactating vulva ectopic breast lesion among clinicians and pathologists. Case Report. We present a case of vulva fibroadenoma associated with lactating adenoma in a 26-year-old Nigerian female. Conclusion. The rarity of vulva ectopic breast tissue can present a diagnostic challenge for both the clinician and the anatomical pathologist. Once excisional biopsy is done and the lesion confirmed histologically, the anxious patient can be reassured.

Anunobi, C. C.; Obiajulu, F. J. N.; Banjo, A. A. F.; Okonkwo, A. O. E.

2013-01-01

5

Angiokeratoma of the vulva.  

PubMed

Angiokeratoma of the vulva is relatively uncommon in the general population. We present two cases of angiokeratoma of the vulva and review the literature. The two patients presented with the complaint of vulvar pruritus. They underwent wide local excision of the lesions. Histopathology revealed angiokeratoma of the vulva. The women remain well with no evidence of recurrence 48 and 32 months after initial surgery. Although it is a rare disease, angiokeratoma of the vulva should be included in the differential diagnosis of a vulvar tumor. PMID:22053688

Terzakis, E; Androutsopoulos, G; Zygouris, D; Grigoriadis, C; Derdelis, G; Arnogiannaki, N

2011-01-01

6

Human ocular sparganosis in southern Brazil.  

PubMed

We report the first case of human ocular sparganosis in the state of Santa Catarina, southern Brazil. A young female patient presented with three periocular moveable inflammatory masses in her right eye, during two years. By surgical excisional biopsy, a helminth larval stage was removed and identified as sparganum. Clinical, laboratory and epidemiological data on this parasite are presented. PMID:21412620

Mentz, Márcia Bohrer; Procianoy, Fernando; Maestri, Marcelo Krieger; Rott, Marilise Brittes

7

Human sparganosis in Thailand: an overview.  

PubMed

Human sparganosis is caused by cestode larvae (spargana) of the genus Spirometra, which exploit copepods as the first intermediate host. A wide range of amphibians, reptiles, birds, and mammals serve as second intermediate/paratenic hosts. Human infections occur mainly by ingesting raw intermediate/paratenic hosts. Cases are found mainly in China, Japan and Korea, and sporadically also in Thailand and other Asian countries. In the period 1943-2010, there were 52 reported cases of sparganosis in Thailand. The average patient age was 32 years (range 11-82 years). From the available patient information, the prevalence of sparganosis infection was higher among females than males, at a ratio of F:M=2:1 (27:15). Patients have mainly been found in the northeast, north, and central regions of Thailand, with only a few in the south. Although a single subcutaneous nodular lesion was the most common feature, about one third of patients had ocular lesions. In particular, patients having ocular lesions were about half of total cases reported pre-1990, with several confirmed cases' applying fresh frog muscle as a poultice to relieve sore eyes, according to traditional medicine. In Thailand, sparganosis is not merely a food-borne disease but is also caused by the traditional belief of applying frog muscles (contaminated with sparganum) to sore eyes. PMID:21459073

Anantaphruti, Malinee T; Nawa, Yukifumi; Vanvanitchai, Yuvadee

2011-04-01

8

Cerebral sparganosis in mainland Chinese patients.  

PubMed

Cerebral sparganosis is a severe parasitic infection caused by the larvae of Spirometra mansoni. We retrospectively reviewed the clinical data of 26 patients with cerebral sparganosis diagnosed in our center and reviewed the literature on cerebral sparganosis in mainland China. Among our 26 patients, 20 suffered from seizures, 11 had limb weakness and 11 experienced headaches. The characteristic MRI features included ring-like enhancement in 24 patients, tunnel lesions in 14 patients and lesion migration in seven patients. Twenty-three patients underwent surgery, with the brain tissues of all patients revealling many inflammatory tunnels. Inside these tunnels, live or degenerate larvae were identified in 20 patients, but only eosinophilic tunnels were identified in the three remaining patients. All patients in this series received praziquantel, with three patients receiving praziquantel alone, with no surgical intervention, and all had a favorable outcome on long term follow-up. At least 82 patients with cerebral sparganosis with histo pathological confirmation have been reported in mainland China. The clinical course, radiological features, and pathological features of mainland Chinese patients were mostly similar to those reported in other regions. There exists an inherent correlation between radiological features and pathological changes, with worm migration causing multiple inflammatory tunnels, especially eosinophilic tunnels, which thus form the basis of tunnel-like or ring-like enhancement on multi-planar MRI, and might be predictors for a poor prognosis. Surgical therapy is optimal in the treatment for cerebral sparganosis, but medication (praziquantel and dexamethasone) has achieved favorable outcomes in some patients. PMID:23911107

Hong, Daojun; Xie, Huiqun; Zhu, Min; Wan, Hui; Xu, Renshi; Wu, Yuchen

2013-07-30

9

Verrucous carcinoma of vulva.  

PubMed

Vulval carcinoma is an uncommon disease of old women and may manifest as verrucous carcinoma. Intraepithelial cancer of the vulna of women in their twenties and thirties is increasing. Invasive carcinoma of vulva usually appears long time after intraepithelial neoplasia or chronic irritation. We are presenting one young lady of 21 years who noticed whitening of vulva since her childhood and irregular vulval itching in that area. After nine to ten years she further noticed swelling in that area which used to discharge off an on along with itching. As she got married and had disturbed sexual life, on consulting with a specialist doctor, the lesion was diagnosed as an ulcerated malignant growth. Further investigation revealed the lesion to be as verrucous carcinoma of vulva. This is the first report of such case in our country. Any persistent complaints of vulva like itching, discharge, even ulcer should be taken care of for detection of intraepithelial vulvar cancer. PMID:17917632

Kabir, N; Ara, I; Ahmed, A; Muhsin, A U

2007-07-01

10

Epithelioid sarcoma of vulva  

Microsoft Academic Search

Epithelioid sarcoma of vulva is an extremely rare and aggressive tumor. In most patients it is asymptomatic, and the lesions\\u000a are usually mistaken for benign processes, leading to diagnosis at later stages. We report a case of vulvar epithelioid sarcoma\\u000a in a 51-yr-old woman presenting with a nodularity of vulva. Left hemivulvectomy with bilateral inguinal lymph node dissection\\u000a was performed.

Kadri Altundag; Oguz Dikbas; Basak Oyan; Alp Usubutun; Alev Turker

2004-01-01

11

Leiomyosarcoma of the vulva.  

PubMed

Malignant tumors of the vulva soft tissue are uncommon. About 1-3% are sarcomas. They can be mistaken as benign lesions, leading to misdiagnosis and mistreatment. A case of a 71-year-old woman with a leiomyosarcoma of the vulva is presented. The surgical excision of the lesion is described and there were no additional malignancies or lesions found. There was no need for adjuvant therapy. PMID:22873106

Salehin, D; Haugk, C; William, M; Hemmerlein, B; Thill, M; Diedrich, K; Friedrich, M

2012-01-01

12

A Case of Inguinal Sparganosis Mimicking Myeloid Sarcoma  

PubMed Central

We report here a case of inguinal sparganosis, initially regarded as myeloid sarcoma, diagnosed in a patient undergone allogeneic hematopoietic transplantation (HSCT). A 56-year-old male patient having myelodysplastic syndrome was treated with allogeneic HSCT after myeloablative conditioning regimen. At day 5 post-HSCT, the patient complained of a painless palpable mass on the left scrotum and inguinal area. Pelvic magnetic resonance imaging and computed tomography revealed suspected myeloid sarcoma. Gun-biopsy was performed, and the result revealed eosinophilic infiltrations without malignancy. Subsequent serologic IgG antibody test was positive for sparganum. Excisional biopsy as a therapeutic diagnosis was done, and the diagnosis of sparganosis was confirmed eventually. This is the first report of sparganosis after allogeneic HSCT mimicking myeloid sarcoma, giving a lesson that the physicians have to consider the possibility of sparganosis in this clinical situation and perform adequate diagnostic and therapeutic approaches.

Yeo, Jin Yeob; Han, Jee Young; Lee, Jung Hwan; Park, Young Hoon; Lim, Joo Han; Lee, Moon Hee; Kim, Chul Soo

2012-01-01

13

Severe sparganosis in Australian tree frogs.  

PubMed

Spargana of Spirometra erinacei infect many vertebrate species, but severe disease from sparganosis has been reported from few host species. Information on the effects of this common, introduced tapeworm of cats on Australian frogs is lacking. Our survey to detect significant diseases in free-ranging amphibians in eastern Australia between 1993 and 2000 revealed that infection with spargana (plerocercoids) of S. erinacei occurred in 12/243 (4.9%) sick frogs. Infections occurred in skeletal muscle and subcutis, especially the thighs, of large adults of Litoria caerulea, Litoria aurea, Litoria gracilenta, and Litoria peronii. Three frogs were also infected in the coelomic cavity. Heavy burdens in seven frogs were associated with poor body condition and debilitating lesions, whereas lighter infections in five sick frogs were considered likely to be incidental to other diseases. In severe infections, a large proportion of thigh muscle was replaced with spargana and various amounts of fibrosis, and some frogs also had myonecrosis, granulomatous inflammation, hemorrhage, and skin ulceration. Concurrent infections were common. Our findings suggest sparganosis is one of a few currently recognized serious diseases affecting free-ranging frogs in Australia. PMID:19901368

Berger, Lee; Skerratt, Lee F; Zhu, Xing-Quan; Young, Sam; Speare, Rick

2009-10-01

14

Sparganosis of liver: a rare entity and review of literature.  

PubMed

Humans are known to serve as the secondary intermediate host for some larval forms of canine or feline tapeworms. Sparganosis is caused by plerocercoid larva of Spirometra of which there are three main species; Spirometra mansoni (or Spirometra erinaceieuropaei), Spirometra mansonoides and Spirometra proliferum. A one-and-half-year-old patient presenting with febrile illness was diagnosed radiologically as a case of liver abscess. The aspirate from the abscess cavity had a thin thread-like worm which was identified as a larval stage of Pseudophyllidea that was further confirmed as belonging to genus Spirometra. Aspiration of the worm and antiparasitic therapy with metronidazole led to complete recovery. Reports of sparganosis from Indian subcontinent are scanty and these cases had involvement of brain, kidney and eye. To the best of our knowledge this is the first case of hepatic sparganosis from India. PMID:23220827

Khurana, Sumeeta; Appannanavar, Suma; Bhatti, Harinder Singh; Verma, Sanjay

2012-12-06

15

Aggressive Angiomyxoma of the Vulva: A Pr?cis for Primary Care Providers  

PubMed Central

Vulvar aggressive angiomyxoma (AA) is a rare mesenchymal tumor of the vulva. Due to its slow-growing nature, it is often overlooked and misdiagnosed by primary care providers (PCPs). We describe a case report of vulvar AA in a 38-year-old woman who underwent complete surgical excision of the neoplasm with no evidence of recurrence on a 5-year followup. A literature review follows to provide PCPs with the clinical, radiologic, and pathologic features that this tumor displays.

Elkattah, R.; Sarkodie, O.; Otteno, H.; Fletcher, A.

2013-01-01

16

Dermatofibrosarcoma protuberans of the vulva.  

PubMed

Dermatofibrosarcoma protuberans of the vulva is an uncommon low-grade sarcoma of dermal origin. Although wide local excision is the treatment of choice, microscopic tumor projections beyond the central tumor nodule explain the tumors' propensity for local recurrence. Frozen sections of margins may be useful to ensure complete resection. The following report contributes two additional patients with this uncommon neoplasm. Notably, one of these two had a fibrosarcomatous area within the dermatofibrosarcoma protuberans. This is the second reported case of a fibrosarcoma arising in a dermatofibrosarcoma protuberans of the vulva. PMID:1869103

Leake, J F; Buscema, J; Cho, K R; Currie, J L

1991-06-01

17

Cerebral sparganosis in children: epidemiological, clinical and MR imaging characteristics  

PubMed Central

Background Cerebral sparganosis in children is an extremely rare disease of central nervous system, and caused by a tapeworm larva from the genus of Spirometra. In this study, we discussed and summarized epidemiological, clinical and MR imaging characteristics of eighteen children with cerebral sparganosis for a better diagnosis and treatment of the disease. Methods Eighteen children with cerebral sparganosis verified by pathology, serological tests and MR presentations were retrospectively investigated, and the epidemiologic and clinical characteristics of the disease were studied. Results Twenty-seven lesions were found in the eighteen children. Twelve lesions in twelve patients were solitary while the lesions in the rest six patients were multiple and asymmetrical. The positions of the lesions were: seven in frontal, eleven in parietal, four in temporal and two in occipital lobes, one in basal ganglia, one in cerebella hemisphere and one in pons. The lesions were presented as slight hypointensity on T1-weighted images but moderate hyperintensity on T2-weighted images with perilesional brain parenchyma edema. Enhanced MR scans by using Gadopentetic Acid Dimeglumine Salt were performed in the patients, and the images demonstrated abnormal enhancements with the patterns of a peripheral ring, or a tortuous beaded, or a serpiginous tubular shape. Follow-up MR scans were preformed for eight patients, and three out of the eight cases exposed migrations and changes in shapes of the lesion areas. Conclusions The MR presentations in our study in general were similar to those in previous studies. However serpiginous tubular and comma-shaped enhancements of lesions have not been previously reported. The enhanced MR imaging and follow-up MR scans with the positive results from serological tests are the most important methods for the clinical diagnosis of cerebral sparganosis in children.

2012-01-01

18

A Case of Sparganosis That Presented as a Recurrent Pericardial Effusion  

PubMed Central

Sparganosis is caused by a larval tapeworm of the genus Spirometra, which commonly invades subcutaneous tissue, but less frequently invades muscle, intestines, spinal cord, and the peritoneopleural cavity. The authors managed a female patient who presented with a recurrent pericardiopleural effusion and peripheral eosinophilia. The anti-sparganum-specific IgG serum level was significantly higher than normal control levels. In this patient, sparganosis was caused by the ingestion of raw frogs in an effort to control her thyroid disease. The recurrent pericardiopleural effusion and peripheral eosinophilia were controlled by 3 consecutive doses of praziquantel (75 mg/kg/day). The patient is doing well 4 years after presentation. Sparganosis should be considered a rare, but possible cause of recurrent pericardial effusion and peripheral eosinophilia. Immunoserologic testing using enzyme linked immunosorbent assays can be helpful in diagnosing human sparganosis, especially in cases without a subcutaneous lump or mass. Praziquantel is an alternative treatment for sparganosis in surgically-unresectable cases.

Lee, Ju-Hee; Kim, Gi-Hyun; Kim, Sang Min; Lee, Sang Yeub; Lee, Won-Yik; Shin, Kyung-Sub; Hwang, Kyung-Kuk; Kim, Dong-Won; Cho, Myeong-Chan

2011-01-01

19

A case of cerebral sparganosis in South America.  

PubMed

Cerebral sparganosis (CS) is a parasitic infection caused by the larva of Spirometra mansonoides. Rarely it can affect the human brain. We report the case of a 24-year old man from Paraguay who suffered from seizures and headache for one year. A frontal tumor was diagnosed by CT-scan and was subsequently resected. The pathological examination revealed a larva with Sparganum characteristics. The evolution of the patient was satisfactory. As far as we know, this is the first case of CS reported in South-America. PMID:1863236

Boero, A M; Garaguso, P; Navarré, J

1991-03-01

20

Other cestodes: sparganosis, coenurosis and Taenia crassiceps cysticercosis.  

PubMed

Many cestodes are capable of invading the central nervous system (CNS), and several are highly prevalent in the developing world. Neurocysticercosis due to Taenia solium and echinococcosis due to Echinoccocus granulosus are two of the most common parasitic infections affecting humans, but other less well-known parasites can also infect the nervous system. Coenurosis, caused by Taenia spp. such as T. multiceps, T. serialis, or T. brauni; sparganosis, caused by Spirometra spp., and neurocysticercosis caused by T. crassiceps are three less frequent zoonotic conditions that should be considered in the differential diagnosis of patients presenting with CNS infection - especially if they have lived in or traveled through areas where these infections are endemic. Diagnosis of these infections is typically made through a combination of serological testing, histopathology, and neuroimaging. PMID:23829923

Lescano, Andres G; Zunt, Joseph

2013-01-01

21

Unilateral ectopic breast tissue on vulva in an adult female.  

PubMed

Among the ectopic breasts, an ectopic breast tissue on vulva is an extremely rare case, especially in adult period. To our knowledge only 38 cases of ectopic breast tissue on vulva are documented in the world literature, out of which only 10 cases of unilateral ectopic breast tissue on vulva has been reported. Because of its rarity here we report a case of unilateral ectopic breast tissue on vulva in an adult female. PMID:23904730

Deshmukh, Santoshkumar Nagnath; Maske, Audumbar N; Deshpande, Akshay P; Shende, Shweta P

2012-02-24

22

Die beginnende Stromainvasion an der Vulva  

Microsoft Academic Search

Fourty one vulvectomy operation specimens and seventeen biopsies from the vulva were examined. They represented either dysplasias, carcinomata in situ or invasive squamous cell carcinomas. Slightly more than a third of the cases showed early stromal invasion as well in dysplasias and carcinomata in situ as in the margins of the invasive carcinomas. On the other hand the early stromal

H. Pickel; E. Burghardt

1976-01-01

23

Sparganosis (Spirometra) in Vertebrates of Taiwan (Republic of China), North Borneo (Malaysia) and Palawan (Republic of the Phillippines).  

National Technical Information Service (NTIS)

Sparganosis has been demonstrated in a long list of vertebrates examined in the course of survey type studies in North Borneo, Palawan, and Taiwan. Spargana were more common in snakes than in other vertebrates examined. Although the occurrence of plerocer...

R. E. Kuntz

1970-01-01

24

Murder misdiagnosed as SIDS: a perpetrator's perspective  

Microsoft Academic Search

AIMSChild murder misdiagnosed as sudden infant death syndrome (SIDS) is a difficult area to study. We present a perpetrator's descriptions to enrich clinicians' knowledge of possible presenting features of this phenomenon.METHODSInterview material was collected as part of a qualitative study of maternal filicide performed from a naturalistic paradigm in order to access the perpetrators' view of events. The woman participant

J Stanton; A Simpson

2001-01-01

25

Robustness and flexibility in nematode vulva development.  

PubMed

The Caenorhabditis elegans vulva has served as a paradigm for how conserved developmental pathways, such as EGF-Ras-MAPK, Notch and Wnt signaling, participate in networks driving animal organogenesis. Here, we discuss an emerging direction in the field, which places vulva research in a quantitative and microevolutionary framework. The final vulval cell fate pattern is known to be robust to change, but only recently has the variation of vulval traits been measured under stochastic, environmental or genetic variation. Whereas the resulting cell fate pattern is invariant among rhabditid nematodes, recent studies indicate that the developmental system has accumulated cryptic variation, even among wild C. elegans isolates. Quantitative differences in the signaling network have emerged through experiments and modeling as the driving force behind cryptic variation in Caenorhabditis species. On a wider evolutionary scale, the establishment of new model species has informed about the presence of qualitative variation in vulval signaling pathways. PMID:22325232

Félix, Marie-Anne; Barkoulas, Michalis

2012-02-09

26

Morphogenesis of the caenorhabditis elegans vulva.  

PubMed

Understanding how cells move, change shape, and alter cellular behaviors to form organs, a process termed morphogenesis, is one of the great challenges of developmental biology. Formation of the Caenorhabditis elegans vulva is a powerful, simple, and experimentally accessible model for elucidating how morphogenetic processes produce an organ. In the first step of vulval development, three epithelial precursor cells divide and differentiate to generate 22 cells of 7 different vulval subtypes. The 22 vulval cells then rearrange from a linear array into a tube, with each of the seven cell types undergoing characteristic morphogenetic behaviors that construct the vulva. Vulval morphogenesis entails many of the same cellular activities that underlie organogenesis and tissue formation across species, including invagination, lumen formation, oriented cell divisions, cell–cell adhesion, cell migration, cell fusion, extracellular matrix remodeling, and cell invasion. Studies of vulval development have led to pioneering discoveries in a number of these processes and are beginning to bridge the gap between the pathways that specify cells and their connections to morphogenetic behaviors. The simplicity of the vulva and the experimental tools available in C. elegans will continue to make vulval morphogenesis a powerful paradigm to further our understanding of the largely mysterious mechanisms that build tissues and organs. PMID:23418408

Schindler, Adam J; Sherwood, David R

27

Severe haematoma of the vulva and defloration caused by goring.  

PubMed

Haematoma of the vulva may occur following a trauma due to its highly vascular structure. We present a case of haematoma of the vulva caused by goring by a cow. The hymen and vaginal wall were also lacerated. Evacuation of the haematoma and repair of lacerated tissues were successfully performed. PMID:15808390

Okur, M Ihsan; Yildirim, Alpagan M; Köse, Rüstü

2005-04-01

28

Severe haematoma of the vulva and defloration caused by goring  

Microsoft Academic Search

Haematoma of the vulva may occur following a trauma due to its highly vascular structure. We present a case of haematoma of the vulva caused by goring by a cow. The hymen and vaginal wall were also lacerated. Evacuation of the haematoma and repair of lacerated tissues were successfully performed.

M. Ihsan Okur; Alpagan M. Yildirim; Rüstü Köse

2005-01-01

29

Extra mammary Paget's disease of the vulva  

PubMed Central

Extra mammary Paget's disease (EMPD) is a rare condition, which affects postmenopausal women. Wide local excision may not be appropriate in elderly patients with extensive disease. It is an uncommon malignant neoplasia with a high local recurrence rate. The standard treatment is local excision of the affected area with adequate margins; however, 40~45% of cases recur after surgery within 4 years. Although surgery is currently considered the preferred primary treatment for EMPD, it has a high relapse rate due to the multifocal nature of the disease. Hence, RT in selected cases of EMPD of vulva may be beneficial.

Barmon, Debabrata; Kataki, Amal Chandra; Imchen, Lima; Sharma, Jagannath Dev

2012-01-01

30

Recurrent vulvovaginal candidosis: focus on the vulva.  

PubMed

Recurrent vulvovaginal candidosis is a frequent disease with a serious impact on women's quality of life. Mostly, recurrences are caused by identical Candida strains suggesting C. albicans persistence in the female anogenital area. Objectives of the presented work were to identify the site of C. albicans persistence, to determine clinical symptoms and signs related to C. albicans positive vulvar cultures and to introduce a new therapeutic approach in women with RVVC. Women with an acute, culture-confirmed episode of RVVC at time of visit were included in this prospective case series. Swabs were obtained from both vagina and inter-labial sulcus. Women received a combined 20-day regimen of 100 mg oral fluconazole and ciclopiroxolamin cream topically. Follow-up visits were at 3, 6, 9 and 12 months. Of 139 women, 105 (76%) had at least one C. albicans positive culture from the external vulva. Vulvar positive cultures correlated with pruritus (OR 5.4; P < 0.001), vulvar edema (OR 3.8; P = 0.03) and fissures (OR 2.4; P = 0.03). Recurrence rates were 27%, 33% and 34% (at 6, 9, 12 months, respectively). The external vulva appears to represent a site of C. albicans persistence and source of endogenous re-infection in patients with RVVC. The combined treatment compared favorably with published fluconazole maintenance regimens. PMID:21615545

Beikert, Florian C; Le, Minh T; Koeninger, Angela; Technau, Kristin; Clad, Andreas

2011-05-25

31

Murder misdiagnosed as SIDS: a perpetrator's perspective  

PubMed Central

AIMS—Child murder misdiagnosed as sudden infant death syndrome (SIDS) is a difficult area to study. We present a perpetrator's descriptions to enrich clinicians' knowledge of possible presenting features of this phenomenon.?METHODS—Interview material was collected as part of a qualitative study of maternal filicide performed from a naturalistic paradigm in order to access the perpetrators' view of events. The woman participant has been convicted for three child murders and two attempted murders which were initially misdiagnosed as SIDS. Interviews were done in the participant's home with her partner present, while she was on leave from prison. Semi-structured interviews were conducted, recorded, transcribed, and analysed for themes. Specific ethical permission was gained to present this case in isolation and the paper was written in consultation with the woman described.?RESULTS—She described initial intense attachment to her first victim and described killing her because she was unable to bear her apnoea attacks and her fear of losing her. She described difficulty grieving for this child and subsequent failure to attach to her next child or feel for the other victims.?CONCLUSIONS—Expressions of intense attachment to an infant and description of intense grief over a death in a way which engages compassion should not deter a paediatrician from considering the possibility of the parent having killed the child.??

Stanton, J; Simpson, A

2001-01-01

32

Autoimmune lymphoproliferative syndrome misdiagnosed as hemophagocytic lymphohistiocytosis.  

PubMed

Autoimmune lymphoproliferative syndrome (ALPS) is a rare inherited disorder of apoptosis, most commonly due to mutations in the FAS (TNFRSF6) gene. It presents with chronic lymphadenopathy, splenomegaly, and symptomatic multilineage cytopenias in an otherwise healthy child. Unfortunately, these clinical findings are also noted in other childhood lymphoproliferative conditions, such as leukemia, lymphoma, and hemophagocytic lymphohistiocytosis, which can confound the diagnosis. This report describes a 6-year-old girl with symptoms misdiagnosed as hemophagocytic lymphohistiocytosis and treated with chemotherapy before the recognition that her symptoms and laboratory values were consistent with a somatic FAS mutation leading to ALPS. This case should alert pediatricians to include ALPS in the differential diagnosis of a child with lymphadenopathy, splenomegaly, and cytopenias; obtain discriminating screening laboratory biomarkers, such as serum vitamin B-12 and ferritin levels; and, in the setting of a highly suspicious clinical scenario for ALPS, pursue testing for somatic FAS mutations when germ-line mutation testing is negative. PMID:24101757

Rudman Spergel, Amanda; Walkovich, Kelly; Price, Susan; Niemela, Julie E; Wright, Dowain; Fleisher, Thomas A; Rao, V Koneti

2013-10-07

33

Cytolytic vaginosis: misdiagnosed as candidal vaginitis.  

PubMed Central

OBJECTIVES: In this study, 210 women with vaginal discharge and other symptoms/signs of genital pathology suggestive of vulvovaginal candidiasis (VVC) were involved in order to distinguish true WC and cytolytic vaginosis (CV) cases. METHODS: Fungal cultures, 10% potassium hydroxide (KOH) and Gram stained preparations and pH measurements were performed on the vaginal discharge material of each patient. RESULTS: Fifteen patients (7.1%) were diagnosed with cytolytic vaginosis according to their clinical and microbiological findings, including abundant lactobacilli, fragmented epithelial cells and/or free nuclei due to cytolysis, seen in their discharge materials on microscopic examination, but no fungal growth. CONCLUSIONS: The results of this study may contribute to the reports in the literature indicating the importance of such disorders, which are generally misdiagnosed as candidiasis.

Cerikcioglu, Nilgun; Beksac, M Sinan

2004-01-01

34

Gelastic seizures misdiagnosed as gastroesophageal reflux disease.  

PubMed

Gastroesophageal reflux disease can have variable manifestations including regurgitation, irritability, arching, choking, and apnea. The disorder is also frequently mistaken for seizures (Sandifer syndrome). We report 6 patients in whom the opposite phenomenon occurred: their seizures were mistaken for gastroesophageal reflux disease. Six of 77 patients (6.8%) with gelastic seizures and epilepsy symptomatic of hypothalamic hamartomas were noted to be misdiagnosed with gastroesophageal reflux disease in infancy. As is typical in these patients, gelastic seizures were not diagnosed until months, or often years, later. Delayed diagnosis of hypothalamic hamartomas can lead to a potentially deleterious syndrome involving refractory epilepsy, developmental problems, and precocious puberty. Gelastic seizures should be considered among the conditions that can mimic reflux symptoms. PMID:17475990

Sweetman, Laura L; Ng, Yu-Tze; Kerrigan, John F

2007-05-01

35

Darier's disease misdiagnosed as severe seborrheic dermatitis.  

PubMed

Darier's disease is a rare autosomal disorder resulting in characteristic findings of the skin, nails, and mucous membranes. Darier's disease is commonly misdiagnosed as seborrheic dermatitis or eczema. We present the case of a young adult active duty Air Force member with 5 years of skin complaints. The 23-year-old patient had been treated for seborrheic dermatitis and eczema with a variety of oral and topical treatments, which did not result in improvement of his symptoms. Upon referral to dermatology, the dermatologist noted skin, nail, and mucous membrane findings consistent with Darier's disease. A skin biopsy histologically confirmed the presence of Darier's disease and treatment was started. Although the course of the disease cannot be stopped, the patient's symptoms did reduce with the appropriate treatment. This case highlights the importance of revisiting the original diagnosis when conventional treatment fails to improve the disease course. PMID:22338367

Schwartz, Jessica L; Clinton, Tony S

2011-12-01

36

Rare sweat gland tumors of vulva: Report of two cases  

PubMed Central

Syringomas and Fox–Fordyce disease are appendageal skin disorders. While syringomas represent an adenoma of the intraepidermal eccrine duct, Fox Fordyce disease occurs due to blockage of the apocrine sweat duct. In both conditions, extragenital sites are more frequently involved than the genitalia. We herein report two young females, one with syringomas on the face and vulva and the other with Fox Fordyce disease involving axilla, areola and vulva, thereby citing the importance of examination of genitalia in these disorders.

Mahajan, Rashmi; Bang, Damodar; Nagar, Amit; Bilimoria, Freny

2012-01-01

37

Malignant fibrous histiocytoma of the vulva: a case report  

Microsoft Academic Search

Background: Primary sarcomas of the vulva are rare tumors that account for 1.8–3% of all vulvar malignancies. Malignant fibrous histiocytoma occurs infrequently on the vulva but nonetheless is the second most frequent sarcoma of this region. The purpose of this report is to review the diagnosis and therapy of this exceedingly rare tumor. Case: A 72-year-old woman was presented with

Birol Vural; Sebiha Özkan; Kür?at Y?ld?z; Ayd?n Çorakç?; Ye?im Gürbüz

2005-01-01

38

Extragastrointestinal stromal tumor originating from the vulva  

PubMed Central

Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract. They have gain-of-function mutations of the c-kit receptor tyrosine kinase gene and have been suggested to originate from the interstitial cells of Cajal. A small percentage of GISTs form extragastrointestinal masses. We report a rare case of a GIST originating from the vulva. A 55-year-old woman presented with a vulvar tumor. The tumor was initially diagnosed as a leiomyosarcoma following the first resection. Following a second recurrence the patient was administered chemotherapy. A third recurrence occurred and the patient underwent a third resection. Histology revealed that a bundle of fibrous tumor cells had invaded the connected tissue and muscular coat, and some spindle-shaped and blunt-ended nuclei were detected. Furthermore, immunohistochemical evaluation revealed that the tumor cells exhibited strong and diffuse staining for c-kit and CD34. The recurrent tumor was diagnosed as a GIST and a reevaluation of the original specimens also revealed a GIST. The patient was treated with imatinib, and is currently healthy with no evidence of recurrence at 20 months after the last surgery.

Fukuda, Takeshi; Sumi, Toshiyuki; Nakano, Yusuke; Morishita, Masanari; Nobeyama, Hiroyuki; Yoshida, Hiroyuki; Matsumoto, Yoshinari; Yasui, Tomoyo; Honda, Ken-ichi; Ishiko, Osamu

2011-01-01

39

Arteriovenous Malformation of the Vulva: A Case Report.  

PubMed

OBJECTIVE: To report the case of a patient with a large and symptomatic vulvar lesion, necessitating surgical excision. CASE: We report the case of a 57-year-old postmenopausal woman with a 6-month history of an enlarging vulvar lesion associated with vulvar pruritus. On examination, a pedunculated 7 × 5 × 4-cm soft tissue mass attached to the left labium majus was noted. Surgical excision was performed and histopathologic evaluation revealed variably dilated, submucosal vessels with thick muscular walls and intimal thickening, but without endothelial atypia or multilayering. These findings were consistent with a final diagnosis of arteriovenous malformation of the vulva. CONCLUSIONS: Given the complex anatomy of the vulva, the differential diagnosis for vulvar vascular lesions can be challenging. Hence, surgical excision and histopathologic evaluation become imperative to distinguish them from other dermatologic and neoplastic conditions of the vulva. PMID:23645069

Pereira, Nigel; Dormosh, Mayes; Mirmanesh, Michael; Guilfoil, Daniel S

2013-05-01

40

Verrucous carcinoma of the vulva: a case report.  

PubMed

Verrucous carcinoma of the female genital tract is a rare lesion, primarily affecting postmenopausal women. We present a 78-year-old patient with verrucous carcinoma of the vulva, who was admitted to the "Aretaieion" Athens University Hospital. She had complained of vulvar itching during the last two years without visiting a specialist doctor. PMID:23401817

Boutas, Ioannis; Sofoudis, Chrisostomos; Kalampokas, Emmanouil; Anastasopoulos, Christos; Kalampokas, Theodoros; Salakos, Nikolaos

2013-01-16

41

Verrucous Carcinoma of the Vulva: A Case Report  

PubMed Central

Verrucous carcinoma of the female genital tract is a rare lesion, primarily affecting postmenopausal women. We present a 78-year-old patient with verrucous carcinoma of the vulva, who was admitted to the “Aretaieion” Athens University Hospital. She had complained of vulvar itching during the last two years without visiting a specialist doctor.

Boutas, Ioannis; Sofoudis, Chrisostomos; Kalampokas, Emmanouil; Anastasopoulos, Christos; Kalampokas, Theodoros; Salakos, Nikolaos

2013-01-01

42

Sandifer syndrome misdiagnosed as refractory partial seizures in an adult.  

PubMed

We report a 27 year-old man with intellectual disability and no prior history of seizures who presented with episodes of abdominal pain, head/eye version and unresponsiveness that were misdiagnosed and treated as partial seizures. Associated vomiting and haematemesis led to the correct diagnosis and treatment of reflux oesophagitis. The episodes immediately resolved and a diagnosis of Sandifer syndrome was made. This is only the second report of Sandifer syndrome in adult, a movement disorder of unknown mechanism that occurs almost exclusively in young children, often misdiagnosed as epilepsy or episodic dystonia. (Published with videosequences). PMID:15075069

Somjit, Sriudomkajorn; Lee, Yong; Berkovic, Samuel F; Harvey, A Simon

2004-03-01

43

A case of streptococcal myositis (misdiagnosed as hamstring injury)  

Microsoft Academic Search

Streptococcal myositis is a very rare bacterial infection of muscle with a high mortality. Diagnosis is difficult because of the paucity of clinical signs and symptoms at the onset. However, presentation of the disease appears to have changed over the last 50 years. A case of streptococcal myositis is presented (misdiagnosed as hamstring injury), which more closely reflects the current

N Kang; D Antonopoulos; A Khanna

1998-01-01

44

Giant fibroepithelial stromal polyp of the vulva: largest case reported  

PubMed Central

Background Fibroepithelial stromal polyps are site-specific mesenchymal lesions that are commonly found in the vulvovaginal region in premenopausal females. These polyps usually are less than 5 cm in diameter and are most commonly identified during routine gynecological examination. Although the stromal polyp is benign, its differential diagnosis includes some malignant vulva lesions making it critical to ensure that an accurate pathologic diagnosis is made. Case We present a case of a 21 year old female with a giant fibroepithelial stromal polyp of the vulva. Upon review of the literature this is the largest reported fibroepithelial stromal polyp to date. Conclusion Fibroepithelial stromal polyps can grow as large as 390 grams and can be 18.5-cm in diameter. Microscopic evaluation of the polyp is critical in the exclusion of malignancy with this diagnosis.

2013-01-01

45

Lateral Microscopic Extension of Squamous Cell Carcinoma of the Vulva  

Microsoft Academic Search

Purpose.The aim of this study was to measure the radial occult microscopic spread of tumor in patients with invasive squamous cell carcinoma of the vulva.Materials and Methods.In the operating room the gross tumor border was marked. The pathologist took a radial section in each quadrant and measured the distance of occult lateral spread of the tumor.Results.From 7\\/01\\/93 to 6\\/30\\/96, 24

Mitchel S. Hoffman; Sivaselvi Gunesakaran; Hector Arango; Steven DeCesare; James V. Fiorica; Michael Parsons; Denis Cavanagh

1999-01-01

46

Vulvar intraepithelial neoplasia and microinvasive carcinoma of the vulva.  

PubMed Central

The pathological, cytological, and clinical features of vulvar intraepithelial neoplasia (VIN) are described. The rate of progression of VIN III to an invasive carcinoma is very low and spontaneous regression can occur. These features prevent the drawing of a direct analogy between vulvar and cervical intraepithelial neoplasia. The concept of microinvasive carcinoma of the vulva is discussed, and it is concluded that no satisfactory definition of this entity has been achieved. Images

Buckley, C H; Butler, E B; Fox, H

1984-01-01

47

Non-neoplastic epithelial disorders of the vulva.  

PubMed

Lichen sclerosus, lichen planus, and lichen simplex chronicus are three of the most common non-neoplastic epithelial disorders of the vulva. Lichen sclerosus is characterized by intense vulvar itching and can affect men and women of all ages, but it manifests most commonly in postmenopausal women. Patients with lichen sclerosus have an increased risk of developing squamous cell carcinoma, and they should be monitored for malignancy. Lichen planus is an inflammatory autoimmune disorder that can affect the vulva and the vagina; it peaks in incidence between ages 30 and 60. There are three clinical variants of lichen planus affecting the vulva: erosive, papulosquamous, and hypertrophic. Lichen simplex chronicus is caused by persistent itching and scratching of the vulvar skin, which results in a thickened, leathery appearance. It is thought to be an atopic disorder in many cases and may arise in normal skin as a result of psychological stress or environmental factors. Definitive diagnosis of non-neoplastic disorders depends on the histology of biopsied tissue. All three disorders are treated with topical corticosteroid ointments of varying potency. Lichen sclerosus and lichen planus are not routinely treated with surgery, which is necessary only in patients who have a malignancy or advanced scarring that causes dyspareunia or clitoral phimosis. Educational counseling teaches patients that even though these chronic disorders cannot be cured, they can be effectively managed. PMID:18297956

O'Connell, Theodore Xavier; Nathan, Leena Shankar; Satmary, Wendy Ann; Goldstein, Andrew T

2008-02-01

48

Primary Breast Adenocarcinoma in Ectopic Breast Tissue in the Vulva  

PubMed Central

Introduction. Accessory breast tissue is a rare finding in the general population with an incidence of 1-2%. An even rarer occurrence is accessory breast tissue afflicted with breast carcinoma. We present a brief report discussing diagnosis and management of a patient who presented with primary breast adenocarcinoma in vulval supranumerary tissue. Brief Report. A 60-year-old Caucasian female presented with a lesion in her left vulva that she first identified during adolescence. The lesion began to grow and ulcerate prompting her to receive treatment. Biopsy was inconclusive, and metastatic workup was negative, so her lesion was treated as an isolated breast lump and removed via wide local excision. Conclusion. Primary breast adenocarcinoma of the vulva is exceedingly rare. A paucity of the literature on this topic unfortunately means that strong evidence does not exist detailing the best management of this patient cohort. However, given that histological data confirms these cancers are virtually the same as breast cancers, it logically follows that the best treatment practices for breast cancer may be applied to treat these patients presenting with primary vulva cancers of ectopic breast tissue.

McMaster, Jason; Dua, Anahita; Dowdy, Sean C.

2013-01-01

49

Quality of Life Among Bipolar Disorder Patients Misdiagnosed With Major Depressive Disorder  

Microsoft Academic Search

Objective: Bipolar disorder is frequently misdiagnosed as major depressive disorder (MDD). We aim to quantify the prevalence of misdiagnosed bipolar disorder among the depres- sion population and evaluate the quality-of-life (QOL) impact of misdiagnoses. Method: Data were collected from 2 self- administered, cross-sectional studies in 2003. Patients participating in The Bipolar Disorder Misdiagnosis Study (N = 1156) were previously diagnosed

A. George Awad; Krithika Rajagopalan; Susan C. Bolge; Diana D. McDonnell

2007-01-01

50

External ophthalmomyiasis caused by Oestrus ovis misdiagnosed as bacterial conjunctivitis.  

PubMed

Ophthalmomyiasis is the infestation of the eye by maggots or bots of certain flies which is mostly caused by Oestrus ovis. The most common form of ophthalmomyiasis is external that only the external surface of the eye is involved. Symptoms of external myiasis are nonspecific so it can be misdiagnosed as any other conjunctivitis if the doctors do not take myiasis into consideration. We report a case series of external ophthalmomyiasis. All the patients complained of mild foreign body sensation, redness, watery eyes and some of them had lid swelling. Larvae on the external surface of the patients must be removed under dim light. Larvae can hide in the fornices of the patients as happened in our two cases. Because of our lack of experience about ophthalmomyiasis, we misdiagnosed the first patient as bacterial conjunctivitis. Ophthalmomyiasis may be difficult to detect so ophthalmologists must keep in mind the possibility of ophthalmic myiasis especially in rural regions. PMID:23780871

Akdemir, Mehmet O; Ozen, Serkan

2013-06-18

51

Emergency laparotomy for misdiagnosed biliary cystadenoma originating from caudate lobe  

PubMed Central

Background Biliary cystadenoma is a rare benign neoplasm, which is often misdiagnosed for a hepatic abscess or a hydatid cyst that tends to recur and is at risk for progression to malignant neoplasm. Case presentation This case describes a 30-year-old woman admitted to our institution in an emergency setting. The patient was originally misdiagnosed as affected by a hepatic hydatid cyst at another hospital, and then emergently treated at our Institution for severe abdominal pain. Histologic evaluation of the cyst showed that it was a biliary cystadenoma and, therefore, the patient underwent a hepatic resection in order to completely remove the lesion. Conclusion Complete excision of any suspicious hepatic cystic lesion remains the best method for diagnosis and treatment of cystadenoma. Incomplete excision of most biliary cystadenoma results in a higher rate of recurrence and the risk of malignant transformation. We report this case to elucidate the clinical presentation, preoperative evaluation, and surgical treatment of these rare lesions.

Ramacciato, Giovanni; Nigri, Giuseppe R; D'Angelo, Francesco; Aurello, Paolo; Bellagamba, Riccardo; Colarossi, Cristina; Pilozzi, Emanuela; Del Gaudio, Massimo

2006-01-01

52

Sparganosis in the lumbar spine : report of two cases and review of the literature.  

PubMed

Sparganosis is a rare parasitic infection affecting various organs, including the central nervous system, especially the lumbar epidural space. This report describes the identification of disease and different strategies of treatments with preoperative information. A 42-year-old man presented with a 2-year history of urinary incontinence and impotence. He had a history of ingesting raw frogs 40 years ago. Magnetic resonance (MR) imaging showed an intramedullary nodular mass at conus medullaris and severe inflammation in the cauda equina. A 51-year-old woman was admitted with acute pain in the left inguinal area. We observed a lesion which seemed to be a tumor of the lumbar epidural space on MR imaging. She also had a history of ingesting inadequately cooked snakes 10 years ago. In the first patient, mass removal was attempted through laminectomy and parasite infection was identified during intra-operative frozen biopsy. Total removal could not be performed because of severe arachnoiditis and adhesion. We therefore decided to terminate the operation and final histology confirmed dead sparganum infection. We also concluded further surgical trial for total removal of the dead worm and inflammatory grannulation totally. However, after seeing another physician at different hospital, he was operated again which resulted in worsening of pain and neurological deficit. In the second patient, we totally removed dorsal epidural mass. Final histology and enzyme-linked immunosorbent assay (ELISA) confirmed living sparganum infection and her pain disappeared. Although the treatment of choice is surgical resection of living sparganum with inflammation, the attempt to remove dead worm and adhesive granulation tissue may cause unwanted complications to the patients. Therefore, the result of preoperative ELISA, as well as the information from image and history, must be considered as important factors to decide whether a surgery is necessary or not. PMID:21607186

Park, Jin Hoon; Park, Young Soo; Kim, Jong Sung; Roh, Sung Woo

2011-04-30

53

Misdiagnosed Uterine Rupture of an Advanced Cornual Pregnancy  

PubMed Central

Cornual pregnancy is a diagnostic and therapeutic challenge with potential severe consequences if uterine rupture occurs with following massive intraabdominal bleeding. We report a case of a misdiagnosed ruptured cornual pregnancy occurring at 21 weeks of gestation. Ultrasound examination and computer tomography revealed no sign of abnormal pregnancy. The correct diagnosis was first made at emergency laparotomy. Uterine rupture should be considered in pregnant women presenting with abdominal pain and haemodynamic instability.

Sant, Christian Linus Hastrup; Andersen, Poul Erik

2012-01-01

54

Invasive Squamous Cell Carcinoma of Vulva: Prognostic Significance of Clinicopathologic Parameters  

Microsoft Academic Search

To investigate the prognostic significance of several clinicopathologic parameters in patients with inva- sive squamous cell carcinoma of the vulva. Methods We retrospectively studied 43 patients with invasive squamous cell carcinoma of the vulva treated with radical vulvectomy at the Department of Gynecology and Obstetrics at Zagreb University School of Medicine, Croatia, in the period from 1978-1996. At the time

Marin Nola; Anto Blaanoviæ

55

Effectiveness of treating non-specific pruritus vulvae with topical steroids: a randomized controlled trial  

Microsoft Academic Search

OBJECTIVE: To determine the effectiveness of triamcinolone cream in the treatment of non-specific pruritus vulvae. METHODS: A total of 50 patients, aged between 8 and 55 years, with non-specific pruritus vulvae were consecutively included in a double-blind randomized controlled trial by their general practitioner in 25 general practices in the Netherlands. Analysis was by \\

Antoine L. M. Lagro-Janssen; Sylvia Sluis

2009-01-01

56

Update in Cancer Chemotherapy: Genitourinary Tract Cancer, Part 6: Cancer of the Uterus and Vulva  

PubMed Central

An update of the state of the art of cancer chemotherapeutic treatment of genitourinary tract cancer is described in this multi-part series: included are cancers of the kidney, bladder, prostate, testicle, ovary, uterus, vulva, and gestational trophoblastic neoplasms. Part 6 is a review of treatment for cancers of the uterus and vulva.

Wright, Jane C.

1988-01-01

57

Relation of Lichen Sclerosus et Atrophicus of the Vulva to Development of Carcinoma.  

National Technical Information Service (NTIS)

One hundred and seven patients with lichen sclerosus et atrophicus (LS/A) of the vulva were studied to determine the malignant potential of the LS/A. Five patients had coexisting invasive carcinoma of the vulva or perineum with the LS/A, and 1 patient had...

W. R. Hart H. J. Norris E. B. Helwig

1974-01-01

58

Pleomorphic type of malignant fibrous histiocytoma with myxoid stroma of the vulva in a young woman.  

PubMed

Malignant fibrous histiocytoma (MFH) of the vulva is extremely rare; to date, there have been nine case reports. Almost all of these cases involved middle-aged women. We encountered a 21-year-old woman with a 4.5 × 2.6 cm superficial, localized, exophytic tumor of the right vulva. Microscopic findings on punch biopsy of the tumor initially suggested a vulvar sarcoma. The patient underwent wide local excision of the vulva. The extirpated specimen demonstrated the pleomorphic type of MFH with myxoid stroma of the vulva. The clinical stage was found to be IIB, based on the American Joint Committee on Cancer staging system. Chromosomal analysis of the tumor using the conventional G-band method was normal (46XX). This seems to be a very rare case of MFH of the vulva in a young woman. Physicians should therefore include MFH in the differential diagnosis of vulvar tumors, even though it is a rare disease. PMID:21564409

Iwakawa, Tokiko; Tsuji, Takahiro; Hamada, Tomonori; Kamio, Masaki; Matsuo, Takashi; Yoshinaga, Mitsuhiro; Kitajima, Shinichi; Douchi, Tsutomu

2011-05-12

59

Multiple angiokeratomas of the vulva: case report and literature review.  

PubMed

Angiokeratomas of the vulva are relatively rare finding and a limited number of cases have been reported in the literature. Clinically, angiokeratomas of the vulva are benign vascular lesions usually occurring in middle-aged or older women. Microscopically these lesions are characterized by epidermal hyperkeratosis, papillomatosis, acanthosis, and marked dilatation of the papillary dermal vessels. In most patients, genital lesions are asymptomatic; however, bleeding, dyspareunia and other symptoms have been described. We report a case of a 45-year-old woman with numerous blue-to-red, scaly papules that spread over the entire area of both labia majora. The patient reported occasional pruritus and burning sensations, discomfort during the intercourse, and significant psychological burden. Histopathologic analysis of the lesion confirmed the diagnosis of angiokeratoma, and all lesions were electrocauterized under local anesthesia. The results of the treatment were very satisfactory, with no side effects or complications. During one-year follow-up, no relapses were noted and the patient remained asymptomatic. Therefore, dermatovenereologists should be aware of angiokeratomas and respective therapeutic options when examining a patient with pruritic, painful, or bleeding lesions in the genital region. PMID:21251446

Buljan, Marija; Poduje, Sanja; Situm, Mirna; Bulat, Vedrana; Bolan?a, Zeljana; Tomas, Davor

2010-01-01

60

Subarachnoid Hemorrhage Misdiagnosed as an Acute ST Elevation Myocardial Infarction  

PubMed Central

Without significant coronary artery stenosis, ischemic electrocardiographic change including ST segment elevation, segmental wall motion abnormality and elevated serum cardiac-specific markers (creatine kinase-MB, Troponin-T) may develop after central nervous system injuries such as subarachnoid, intracranial or subdural hemorrhage. Misdiagnosing these patients as acute myocardial infarction may result in catastrophic outcomes. By reporting a case of a 55-year old female with subarachnoid hemorrhage mimicking acute ST elevation myocardial infarction, we hope to underline that careful attention of neurologic abnormality is critical in making better prognosis.

Heo, Woon Je; Jeong, Woo Shin; Jeong, Mi Yeon; Lee, Sang Hyuk; Seo, Jeong Yeun; Jo, Sang Won

2012-01-01

61

Extrahepatic Textiloma Long Misdiagnosed as Calcified Echinococcal Cyst  

PubMed Central

Textiloma or gossypiboma is a retained surgical swab in the body after an operation and is a complication that can remain undetected for many years and may represent a diagnostic dilemma depending on its location. It may be confused with several focal lesions and an accurate history taking, combined with clinical and instrumental data, is key to suspecting the diagnosis. We report a case of abdominal textiloma that was initially misdiagnosed as echinococcal cyst and discuss the differential diagnosis based on sonographic features and the WHO-IWGE classification.

Cattaneo, Federico; Graffeo, Massimo; Brunetti, Enrico

2013-01-01

62

Extrahepatic textiloma long misdiagnosed as calcified echinococcal cyst.  

PubMed

Textiloma or gossypiboma is a retained surgical swab in the body after an operation and is a complication that can remain undetected for many years and may represent a diagnostic dilemma depending on its location. It may be confused with several focal lesions and an accurate history taking, combined with clinical and instrumental data, is key to suspecting the diagnosis. We report a case of abdominal textiloma that was initially misdiagnosed as echinococcal cyst and discuss the differential diagnosis based on sonographic features and the WHO-IWGE classification. PMID:23533840

Cattaneo, Federico; Graffeo, Massimo; Brunetti, Enrico

2013-02-26

63

Basal cell carcinoma of the vulva presenting as unilateral pruritus.  

PubMed

Basal cell carcinoma (BCC) is the most common human malignancy, which often occurs as a result of ultraviolet light on sun-exposed areas. A more rare location for the presentation of BCC is the non-sun-exposed genital area, where squamous cell cancer occurs frequently in the setting of human papilloma virus and chronic inflammatory lesions (i.e., lichen sclerosus et atrophicus). Consequently, such tumors may escape detection by the dermatologist and be mistaken by the gynecologist for an inflammatory condition. A delay in diagnosis can result in wider surgical margins and potential recurrences. We present a case of BCC of the vulva with involvement of the clitoris presenting with unilateral pruritus and treated as an allergic contact dermatitis with topical corticosteroids. The patient was treated with Mohs micrographic surgery in conjunction with topical imiquimod to spare surrounding tissue. PMID:18380212

Saini, Ritu; Sarnoff, Deborah S

2008-03-01

64

[Elephantiasis of the vulva of an unclear etiology: case report].  

PubMed

A patient with vulvar elephantiasis, which had been developing since 1985 when biopsy was first performed showing only signs of chronic inflammation, is described. From 1985-1987 (when she was first admitted to the hospital) microbiological analyses were negative and antibiotic therapy was administered without success. At the first admittance abscess of the left Bartholin's gland and furunculosis of vulva were diagnosed. Serological tests to agents that usually cause vulval infections with elephantiasis were negative, and microbiological analyses revealed mixed bacterial flora. Biopsy showed again only nonspecific chronic inflammation. The patient received ampicyllin, oxytetracyclin and doxycillin. She did not return for the control until 1993. At that time the vulvar mass reached 16:13:10 cm and was surgically removed. The histological picture showed chronic granulomatous inflammation. The results of microbiological and serological tests were again the same as before. PMID:8965631

Kos, M; Ljubojevi?, N; Ili?-Forko, J; Babi?, D; Juki?, S

65

Squamous Cell Carcinoma of the Vulva Stage IA: Long-Term Results  

Microsoft Academic Search

Objective. The aim of this study was to evaluate the risk of metastases to lymph nodes and long-term results of radical and modified radical surgery in patients with a T1 squamous cell carcinoma of the vulva and ?1 mm of invasion.Methods. A retrospective review of 40 patients with T1 squamous cell carcinoma of the vulva and ?1 mm of invasion

Javier F. Magrina; Jesus Gonzalez-Bosquet; Amy L. Weaver; Thomas A. Gaffey; Kevin O. Leslie; Maurice J. Webb; Karl C. Podratz

2000-01-01

66

Paget's Disease of the Vulva in Premenopausal Woman Treated with Only Surgery: A Case Report  

PubMed Central

Paget's disease of the vulva remains a rare condition with only a limited number of cases reported in the literature. It is an uncommon neoplasm usually of postmenopausal white women characterized by controversies in its prevalence, clinical features, treatment strategies, and prognostic. We here report a case of a primary Paget's disease of the vulva in premenopausal woman treated by only surgery with a favorable issue.

Asmouki, Hamid; Oumouloud, Rachid; Aboulfalah, Abderrahim; Soummani, Abderraouf; Marrat, Abdelouahed

2012-01-01

67

Nodular Fasciitis of the Breast Previously Misdiagnosed as Breast Carcinoma.  

PubMed

BACKGROUND: Nodular fasciitis of the breast is a rare benign pathology that can mimic breast cancer clinically, radiologically, and histopathologically. CASE REPORT: An 18-year-old female patient had first visited a physician in a different center with the complaint of a lump in her left breast. Breast examination had revealed a palpable mass located in the left upper outer quadrant. Ultrasonography had demonstrated a hypoechoic lesion. Excisional biopsy of the lump had been performed and histopathologic examination misdiagnosed this lump as a mesenchymal tumor. The patient was then referred to our clinic for further investigations. Pathologic revision was performed and the diagnosis of nodular fasciitis of the breast was established. CONCLUSION: Awareness of this rare clinical entity, nodular fasciitis, in the breast eliminates the misdiagnosis of breast cancer. PMID:20877676

Ozben, Volkan; Aydogan, Fatih; Karaca, Fatih Can; Ilvan, Sennur; Uras, Cihan

2009-12-16

68

Nodular Fasciitis of the Breast Previously Misdiagnosed as Breast Carcinoma  

PubMed Central

Summary Background Nodular fasciitis of the breast is a rare benign pathology that can mimic breast cancer clinically, radiologically, and histopathologically. Case Report An 18-year-old female patient had first visited a physician in a different center with the complaint of a lump in her left breast. Breast examination had revealed a palpable mass located in the left upper outer quadrant. Ultrasonography had demonstrated a hypoechoic lesion. Excisional biopsy of the lump had been performed and histopathologic examination misdiagnosed this lump as a mesenchymal tumor. The patient was then referred to our clinic for further investigations. Pathologic revision was performed and the diagnosis of nodular fasciitis of the breast was established. Conclusion Awareness of this rare clinical entity, nodular fasciitis, in the breast eliminates the misdiagnosis of breast cancer.

Ozben, Volkan; Aydogan, Fatih; Karaca, Fatih Can; Ilvan, Sennur; Uras, Cihan

2009-01-01

69

Unilateral presentation of postpartum cardiomyopathy misdiagnosed as pneumonia  

PubMed Central

A 34-year-old woman presented to the emergency department with severe dyspnoea 10 days following a normal-course caesarean delivery. She had been experiencing shortness of breath throughout the third trimester of pregnancy accompanied by tachycardia (110 bpm); however, her evaluation did not include ECG or chest radiography to elucidate the cause. Following delivery, chest radiography was performed demonstrating predominantly unilateral findings interpreted as pneumonia. ECG revealed T-wave inversion in leads V4–V6, which was unaddressed. Overnight she deteriorated and a chest CT angiography was performed demonstrating heart enlargement and pulmonary oedema. An echocardiogram established a diminished ejection fraction (EF) of 15–20%, suggesting the diagnosis of peripartum cardiomyopathy. She was treated with angiotensin-converting enzyme inhibitors, spirinolactone and furosemide, and was free of symptoms the following month with an EF of 40–45%. Though uncommon, heart failure is a potentially fatal cause of peripartum dyspnoea, often misdiagnosed, meriting further attention.

Amit, Ben Hayman; Marmor, Alon; Hussein, Amer

2010-01-01

70

A Case of Dowling-Degos Disease on the Vulva  

PubMed Central

Dowling-Degos disease (DDD) is an autosomal dominant genodermatosis and this disease is a genetically determined disturbance of epidermal proliferation. It is characterized by acquired, slowly progressive pigmented lesions that primarily involve the great skin folds and flexural areas such as the axilla, neck, limb flexures, the inframammary area and the inguinal folds. The vulva is an unusual location for DDD. A 41-year-old woman presented with a 10-year history of multiple, small, reticulated and brownish macules distributed symmetrically on the bilateral external genital regions. We found no other similarly pigmented skin lesions on her body, including the flexural areas. There was no known family history of similar eruptions or pigmentary changes. The histologic examination showed irregular rete ridge elongation with a filiform or antler-like pattern and basilar hyperpigmentation on the tips. Fontana-Masson staining showed increased pigmentation of the rete ridges and the S100 protein staining did not reveal an increased number of melanocytes in the epidermis. From these findings, we diagnosed this lesion as DDD.

Kang, Ho Song; Hur, Jae; Lee, Jung Woo; Oh, Dae Heon; Yeo, Kwang Yeoll; Kim, Joung Soo

2011-01-01

71

Treatable Neurological Disorders Misdiagnosed as Creutzfeldt - Jakob disease  

PubMed Central

Objective Heightened awareness of Creutzfeldt-Jakob disease (CJD) among physicians and the lay public has led to its frequent consideration in the differential diagnosis of patients with rapidly progressive dementia (RPD). Our goal was to determine which treatable disorders are most commonly mistaken for CJD. Methods We performed a retrospective clinical and neuropathological review of prion-negative brain autopsy cases referred to the US National Prion Disease Pathology Surveillance Center (NPDPSC) at Case Western Reserve University from January 2006 through December 2009. Results Of 1,106 brain autopsies, 352 (32%) were negative for prion disease, 304 of which had adequate tissue for histopathological analysis. Alzheimer disease (154) and vascular dementia (36) were the two most frequent diagnoses. Seventy one patients had potentially treatable diseases. Clinical findings included dementia (42 cases), pyramidal (20), cerebellar (14), or extrapyramidal (12) signs, myoclonus (12), visual disturbance (9) and akinetic mutism (5); a typical electroencephalogram occurred only once. Neuropathological diagnoses included immune-mediated disorders (26), neoplasia (25, most often lymphoma), infections (14), and metabolic disorders (6). Interpretation In patients with RPD, treatable disorders should be considered and excluded before diagnosing CJD. Misdiagnosed patients often did not fulfill WHO criteria. RPD with positive 14-3-3 CSF protein should not be regarded as sufficient for the diagnosis of CJD. Adherence to revised criteria for CJD, which include distinctive MRI features of prion disease, is likely to improve diagnostic accuracy.

Chitravas, Numthip; Jung, Richard S.; Kofskey, Diane M.; Blevins, Janis E.; Gambetti, Pierluigi; Leigh, R. John; Cohen, Mark L.

2011-01-01

72

Keratocystic odontogenic tumour (KCOT) misdiagnosed as a dentigerous cyst.  

PubMed

Keratocystic odontogenic tumours are known for their peculiar behaviour, varied origin, debated development, unique tendency to recur and disputed treatment modalities. Thus, it has been the subject of much research over the last 40 years. It was formerly known as odontogenic keratocyst (OKC). OKC received its new title as keratocystic odontogenic tumour (KCOT) by the WHO (2005) in order to suggest its aggressive and recurrent nature. KCOT is a benign intraosseous neoplasm of the jaw. Involvement of the maxillary sinus is an unusual presentation. We present the case of an 11-year-old child with extensive KCOT and an impacted canine in the right maxillary sinus. The cyst was initially misdiagnosed to be a dentigerous cyst based on the clinical and radiographic features though a differential diagnosis of KCOT and adenomatoid odontogenic tumour was made. The histological examination of the specimen finally confirmed it to be a KCOT. The clinical, radiological and histological features of this tumour along with its surgical management have been discussed. PMID:23429028

Chaudhary, Seema; Sinha, Ashish; Barua, Pranamee; Mallikarjuna, Rachappa

2013-02-20

73

Angiogenesis in Paget's Disease of the Vulva and the Breast: Correlation with Microvessel Density  

PubMed Central

Our understanding of the pathogenesis of Paget's disease of the vulva and the breast remains limited. Current evidence supports the fact that angiogenesis plays an important role in the pathogenesis of several diseases. Therefore, we sought to define its role, as correlated with microvessel density, in Paget's disease of the vulva and the breast. Microvessels were analysed using anti-von Willebrand factor antibody in 105 cases of Paget's disease of the vulva and the breast comprising 71 cases of Paget's disease of the vulva, including 8 cases with invasive disease, and 34 cases of Paget's disease of the breast. The latter included 12 cases with DCIS, 5 cases with both DCIS and invasive carcinoma, and 6 with carcinoma alone. Eleven cases had no underlying tumour identified. Increased microvessel density was demonstrated in Paget's disease of the breast with DCIS and with carcinoma alone compared to Paget's disease of the breast alone, P < 0.08 and P < 0.013, respectively. There were no significant differences in microvessel density in the vulval cases. Neovascularisation is an important process in the development of Paget's disease of the breast. Other biological and molecular processes are more involved in the pathogenesis of Paget's disease of the vulva.

Ellis, Patricia E.; MacLean, Allan B.; Wong Te Fong, L. F.; Crow, Julie C.; Perrett, Christopher W.

2012-01-01

74

The Definition of Optimal Inguinal Femoral Nodal Dissection in the Management of Vulva Squamous Cell Carcinoma  

Microsoft Academic Search

Objectives  To reject the hypothesis that the number of nodes removed at time of surgical staging for vulva cancer is not an important\\u000a prognostic factor.\\u000a \\u000a \\u000a \\u000a Methods  Retrospective chart reviews were carried out from 1980-2004 to identify patients with squamous cell vulva carcinoma treated\\u000a with radical vulvectomy and bilateral inguinal femoral lymph node dissection. Patients’ demographics, disease characteristics,\\u000a the number of lymph nodes

Tien Le; Ramadan Elsugi; Laura Hopkins; Wylam Faught; Michael Fung-Kee-Fung

2007-01-01

75

Intraepithelial and invasive neoplasia of the vulva in association with human papillomavirus infection.  

PubMed

Colposcopic examination of 335 women with cytologically detected human papillomavirus (HPV) revealed involvement of the cervix in 316 patients (94%), vagina in 276 (82%) and vulva in 148 (44%). A symptom complex of pruritus and superficial dyspareunia was found in 98 of the 148 patients with vulvar infection (66%). Histologic examination revealed HPV-associated vulvar intraepithelial neoplasia (VIN) in 11 of 148 biopsies (7.4%). Follow-up of the patients with HPV infection with or without VIN showed a spontaneous regression rate of 56% but also demonstrated progression to VIN 3 in two patients and to invasive carcinoma of the vulva in one. PMID:2841459

Planner, R S; Hobbs, J B

1988-06-01

76

A tumoriform lesion of the vulva with features of mammary-type fibrocystic disease.  

PubMed

: Fibrocystic disease is a common benign lesion of the breast. Variably sized cysts, apocrine metaplasia, fibrosis, calcification, chronic inflammation, and epithelial hyperplasia are the basic morphological changes seen in mammary fibrocystic disease. We report a rare tumoriform lesion of the vulva with features of fibrocystic disease, which seems to be the first description of this condition in the vulva. The pertinent literature is discussed. The reported lesion further demonstrates the analogy between tumors of anogenital mammary-like glands and mammary neoplasms. PMID:23435363

Konstantinova, Anastasia M; Kacerovska, Denisa; Michal, Michal; Kazakov, Dmitry V

2013-10-01

77

Severe infection of wild-caught snakes with Spirometra erinaceieuropaei from food markets in Guangzhou, China involves a risk for zoonotic sparganosis.  

PubMed

Wild-caught snakes are a popular and traditional food in China. However, little known to the public, snakes are also intermediate hosts of Spirometra erinaceieuropaei, a food- and water-borne pathogen of sparganosis. Therefore, we investigated the prevalence of S. erinaceieuropaei in 10 popular species of wild-caught snakes in Guangzhou City (Guangdong Province) between July 2009 and July 2010. One hundred and twenty-four specimens of 10 species (including Enhydris plumbea, Zoacys dhumnades, Elaphe radiate, Elaphe taeniura, Elaphe carinata, Ptyas mucosus, Ptyas korros, Naja naja atra, Bungarus fasciatus, and Bungarus multicinctus) were randomly selected from a total of 1,160 wild-caught snakes. They were obtained from food markets in 5 representative districts (Huadou, Panyu, Tianhe, Haizhu, and Conghua). The specimens were killed, necropsied, and examined for parasitic helminths. Of the snakes examined, 29.8% were infected by spargana and the worm burden per infected snake ranged from 1 to 221. Most species were infected except for En. plumbea, B. fasciatus, and B. multicinctus. Prevalence even reached 100% in Zoacys dhumnades. More than half (53.5%) of the spargana were located in muscular tissue, 36.4% in subcutaneous tissue, and 10.1% in the coelomic cavity. The study revealed the potential risk for the zoonotic sparganosis by eating wild-caught snakes and will be helpful in arousing public health concern about the consumption of snake meat. PMID:21348631

Wang, Fumin; Zhou, Lihua; Gong, Shiping; Deng, Yanzhong; Zou, Jiejian; Wu, Jun; Liu, Wenhua; Hou, Fanghui

2010-09-01

78

A Multivariate Analysis of Clinical and Morphological Prognostic Factors in Squamous Cell Carcinoma of the Vulva  

Microsoft Academic Search

Clinical and histological data of 168 patients with squamous cell carcinoma of the vulva were analyzed with respect to survival. 151 patients underwent surgery, 12 patients were treated with primary radiation and in 5 patients no treatment was performed. Follow-up lasted from at least 2 up to 22 years’ posttreatment. In univariate analysis, the following factors were highly significant: presurgery

B. Smyczek-Gargya; B. Volz; M. Geppert; J. Dietl

1997-01-01

79

[Surgical treatment of early-stage vulva carcinoma and the complications of the operation  

Microsoft Academic Search

The treatment of patients with early-stage squamous-cell carcinoma of the vulva (with a depth of invasion > 1 mm), i.e. stage T1 with a tumour diameter < or = 2 cm or T2 with a diameter > 2 cm without suspect groin nodes on palpation, has become less radical; in this way, the complications can be reduced without compromising the

J. A. de Hullu; A. van der Zee

2005-01-01

80

Preliminary characterization of the normal microbiota of the human vulva using cultivation-independent methods  

Microsoft Academic Search

Theobjectiveofthis studywastoperform apreliminary characterization ofthe microbialpopulations of the normal human vulva. Genomic DNA was isolated from samples of the labia majora and labia minora from four healthy women, and sequences of bacterial 16S rRNA genes in each were determined. The sequences were compared with those of known bacterial species to classify the numerically abundant populations in these communities. Even among

Celeste J. Brown; Mayee Wong; Catherine C. Davis; Amita Kanti; Xia Zhou; Larry J. Forney

2007-01-01

81

Embryology and anatomy of the vulva: the female orgasm and women's sexual health  

Microsoft Academic Search

Sexual health is vital to overall well-being. Orgasm is a normal psycho-physiological function of human beings and every woman has the right to feel sexual pleasure. The anatomy of the vulva and of the female erectile organs (trigger of orgasm) is described in human anatomy textbooks. Female sexual physiology was first described in Dickinson's textbook in 1949 and subsequently by

Vincenzo Puppo

2011-01-01

82

Diagnosis of Primary Langerhans Cell Histiocytosis of the Vulva in a Postmenopausal Woman  

PubMed Central

Langerhans cell histiocytosis (LCH) is a very rare disease of female genital tract, most commonly seen in vulva and unusual in postmenopausal period. Herein, we report the 8th case of pure vulvar LCH in a postmenopausal woman. We pay attention to the differential diagnosis in postmenopausal state, features of pathologic diagnosis, and treatment options.

Kurt, Sefa; Kopuz, Aycan; Solakoglu Kahraman, Dudu; Tasyurt, Abdullah

2013-01-01

83

Pristionchus pacificus vulva formation: polarized division, cell migration, cell fusion, and evolution of invagination  

Microsoft Academic Search

Tube formation is a widespread process during organogenesis. Specific cellular behaviors participate in the invagination of epithelial monolayers that form tubes. However, little is known about the evolutionary mechanisms of cell assembly into tubes during development. In Caenorhabditis elegans, the detailed step-to-step process of vulva formation has been studied in wild type and in several mutants. Here we show that

Irina Kolotuev; Benjamin Podbilewicz

2004-01-01

84

A female adult with Sandifer's syndrome and hiatal hernia misdiagnosed as epilepsy with focal seizures.  

PubMed

Sandifer's syndrome is a rare, probably underdiagnosed, and usually pediatric movement disorder associated with gastroesophageal reflux disease. Often, it is misdiagnosed as epilepsy or paroxysmal dyskinesia. We report the case of an adult female with Sandifer's syndrome initially diagnosed as focal epilepsy and treated inefficiently with anticonvulsants for two years. PMID:22483645

Nowak, Mareike; Strzelczyk, Adam; Oertel, Wolfgang H; Hamer, Hajo M; Rosenow, Felix

2012-04-05

85

Disseminated Mucormycosis in a Patient with Acute Myeloblastic Leukemia Misdiagnosed as Infection by Enterococcus faecium  

PubMed Central

Mucormycosis is a rare complication in cancer patients. This report presents the case of a acute myeloblastic leukemia patient who developed an ascending paralysis due to disseminated mucormycosis. The presentation was unusual because the early symptoms were fever and pain, and the disease was misdiagnosed because of a concomitant infection by Enterococcus faecium.

Sammassimo, S.; Mazzotta, S.; Tozzi, M.; Gentili, S.; Lenoci, M.; Santopietro, R.; Bucalossi, A.; Bocchia, M.; Lauria, F.

2004-01-01

86

Bowenoid Papulosis of the Vulva and Subsequent Periungual Bowen's Disease Induced by the Same Mucosal HPVs  

PubMed Central

We report the case of a 23-year-old woman who developed bowenoid papulosis of the vulva and subsequent periungual Bowen's disease. She had a history of a long standing periungual wart on her right thumb before the outbreak of periungual Bowen's disease. By HPV DNA chip, human papillomavirus (HPV) 11, 18 and 31 were identified from the periungual lesions, and HPV 11, 18 and 33 from the vulvar lesion. This case supports the theory of anogenital-digital spread of HPV, and proposes that the periungual wart may change into Bowen's disease by mucosal HPVs. To the best of our knowledge, this case is important as the first Korean case of periungual Bowen's disease concurrent with bowenoid papulosis of the vulva.

Shim, Woo-Haing; Park, Hyun-Je; Kim, Hoon-Soo; Kim, Su-Han; Jung, Do-Sang; Ko, Hyun-Chang; Kim, Byung-Soo; Kwon, Kyung-Sool

2011-01-01

87

Bowenoid Papulosis of the Vulva and Subsequent Periungual Bowen's Disease Induced by the Same Mucosal HPVs.  

PubMed

We report the case of a 23-year-old woman who developed bowenoid papulosis of the vulva and subsequent periungual Bowen's disease. She had a history of a long standing periungual wart on her right thumb before the outbreak of periungual Bowen's disease. By HPV DNA chip, human papillomavirus (HPV) 11, 18 and 31 were identified from the periungual lesions, and HPV 11, 18 and 33 from the vulvar lesion. This case supports the theory of anogenital-digital spread of HPV, and proposes that the periungual wart may change into Bowen's disease by mucosal HPVs. To the best of our knowledge, this case is important as the first Korean case of periungual Bowen's disease concurrent with bowenoid papulosis of the vulva. PMID:22148018

Shim, Woo-Haing; Park, Hyun-Je; Kim, Hoon-Soo; Kim, Su-Han; Jung, Do-Sang; Ko, Hyun-Chang; Kim, Byung-Soo; Kim, Moon-Bum; Kwon, Kyung-Sool

2011-11-03

88

F-actin accumulates in the vulva of female Strongyloides venezuelensis.  

PubMed

Little is known about the actin cytoskeleton architecture in female Strongyloides venezuelensis and thus to investigate the distribution and concentration of actin, female worms were labelled with phalloidin-rhodamine and visualized under confocal microscopy. Our results demonstrate that filamentous actin accumulates in the vulva and the concentration of F-actin at this site suggests its important role, especially during oviposition, in the life cycle of S. venezuelensis. PMID:22776357

Silva, C V; Gonçalves, A L R; Cruz, L; Cruz, M C; Ueta, M T; Costa-Cruz, J M

2012-07-10

89

Primary Breast Carcinoma of the Vulva: A Case Report and Literature Review  

Microsoft Academic Search

Background.In 1872, Hartung was the first to describe the case of a fully formed mammary gland arising in the left labium majora of a 30-year-old woman. Since Hartung's initial report, 38 additional cases of ectopic vulvar breast tissue have been described. This case report describes the rare occurrence of primary mammary adenocarcinoma arising within the vulva.Case.A 64-year-old G4P4 white female

William P. Irvin; Helen P. Cathro; William W. Grosh; Laurel W. Rice; Willie A. Andersen

1999-01-01

90

Squamous cell carcinoma of the vulva in a virgin patient with Turner syndrome.  

PubMed

Two types of gynecologic tumors are commonly described in the Turner syndrome, the first one is gonadoblastoma, which occurs in patients with Y chromosome abnormalities, and the second one is endometrial carcinoma which is mostly related with exogenous estrogen usage. Here, we describe an extremely rare case of squamous cell carcinoma of the vulva in a virgin woman with Turner syndrome. A 35-years old single, virgin woman referred to our Oncology Department with warty, necrotized, exophytic 6-7 cm vulvar mass. She had a history of primary amenorrhea and mosaic Turner syndrome was determined in her karyotype analysis. Biopsy specimen of the vulvar mass revealed squamous cell carcinoma of the vulva, and total vulvectomy with inguinal femoral lymphadenectomy was performed. The postoperative course was uneventful and there has been no recurrence of the disease up to date. Women with Turner syndrome have streak ovaries that produce very low estrogen and the squamous cell carcinoma of the vulva may have developed at an early age with Turner syndrome because of this low estrogen value similar to postmenopausal women. The current case is a special case due to its age of occurrence, virgin and Turner syndrome status. PMID:21998766

Tapisiz, Omer Lutfi; Topcu, Onur; Gungor, Tayfun; Ozdal, Bulent; Sirvan, Levent; Yesilyurt, Ahmet

2011-09-28

91

Determination of iron status in women attending genitourinary clinics with pruritus vulvae  

PubMed Central

Objective To compare iron status in women with pruritus vulvae and in asymptomatic controls. Methods 42 women with pruritus vulvae and 42 asymptomatic broadly age?matched controls were enrolled in this prospective study. The outcome measures assessed were serum iron, serum ferritin, total iron?binding capacity, haemoglobin and transferrin saturation. Results 12 (29%) participants and 10 (24%) controls were iron deficient; 1 (2%) participant and 1 (2%) control had laboratory?defined iron deficiency anaemia. Participants generally had lower levels of iron markers than controls, with differences (95% confidence interval (CI)) of ?3.5??g/l (?9.89 to 6.99) for serum ferritin (p?=?0.73), ?4.9?mmol/l (?8.12 to 0.12) for serum iron (p?=?0.06) and ?5.5?mmol/l (?5.75 to 1.46) for total iron?binding capacity (p?=?0.24). No significant difference in haemoglobin or mean cell volume was shown between the two groups (haemoglobin: p?=?0.17, 95% CI ?0.83 to 0.15; mean cell volume: p?=?0.15, 95% CI ?4.59 to 0.73). Conclusion This study does not provide evidence to support the routine determination of iron status in patients presenting to genitourinary medicine clinics with pruritus vulvae from all causes.

Bates, S M; Dilke-Wing, G

2006-01-01

92

Squamous cell carcinoma of the vulva in a virgin patient with Turner syndrome  

PubMed Central

Two types of gynecologic tumors are commonly described in the Turner syndrome, the first one is gonadoblastoma, which occurs in patients with Y chromosome abnormalities, and the second one is endometrial carcinoma which is mostly related with exogenous estrogen usage. Here, we describe an extremely rare case of squamous cell carcinoma of the vulva in a virgin woman with Turner syndrome. A 35-years old single, virgin woman referred to our Oncology Department with warty, necrotized, exophytic 6-7 cm vulvar mass. She had a history of primary amenorrhea and mosaic Turner syndrome was determined in her karyotype analysis. Biopsy specimen of the vulvar mass revealed squamous cell carcinoma of the vulva, and total vulvectomy with inguinal femoral lymphadenectomy was performed. The postoperative course was uneventful and there has been no recurrence of the disease up to date. Women with Turner syndrome have streak ovaries that produce very low estrogen and the squamous cell carcinoma of the vulva may have developed at an early age with Turner syndrome because of this low estrogen value similar to postmenopausal women. The current case is a special case due to its age of occurrence, virgin and Turner syndrome status.

Topcu, Onur; Gungor, Tayfun; Ozdal, Bulent; Sirvan, Levent; Yesilyurt, Ahmet

2011-01-01

93

Primary Ewing's sarcoma of vulva: a case report and a review of the literature.  

PubMed

Ewing sarcomas/peripheral primitive neuroectodermal tumors (ES/pPNET) are extremely rare in the vulva. A review of the literature reveals only 14 previously reported possible cases. Here we reported a case of primary extraskeletal Ewing's sarcoma (EES) of the vulva in a 37-year-old woman. Characteristic histologic features of ES/pPNET were present in this case, including a monomorphic population of small round blue cells with cytoplasmic glycogen confirmed by periodic acid-Schiff, membrane staining with CD99 and nuclear staining with FLI-1. After surgery, the patient was found to have pulmonary metastasis and then received six cycles of polychemotherapy. She is still alive with stable disease after 1 year of follow up. Our findings underline the crucial role of immunohistochemical techniques in the differential diagnosis of small round cell tumors in these unusual locations. We also give a summary about the clinical and pathological features of the primary ES/pPNET in the vulva reported previously in the literature. PMID:23106919

Che, Shao-Min; Cao, Pei-Long; Chen, Hong-Wei; Liu, Zi; Meng, Du

2012-10-29

94

Metastatic Crohn's disease accompanying granulomatous vasculitis and lymphangitis in the vulva  

PubMed Central

Metastatic Crohn’s disease (CD) is an extremely rare extragastrointestinal manifestation of CD, and is characterized histopathologically by the presence of non-caseating granulomatous inflammation. Granulomatous vasculitis and lymphangitis have rarely been documented in metastatic CD. Herein, we report the first documented case of metastatic CD accompanied by both granulomatous vasculitis and lymphangitis in the vulva. A 35-year-old Japanese female with CD presented with multiple small nodules in her vulva. Biopsy was performed under a clinical diagnosis of genital warts. A histopathological study revealed marked lymphangiectasia in the papillary dermis. Within the dilated lymphatics, lymphocytes and aggregates of macrophages were present, which are typical features of granulomatous lymphangitis. Tiny non-caseating granulomas and granulomatous vasculitis were also observed. Accordingly, a diagnosis of metastatic CD accompanied by both granulomatous vasculitis and lymphangitis was made. The occurrence of cutaneous lesions in patients with CD is well known. Albeit extremely rare, lymphangiectasia has been reported in the vulva of CD patients that clinically mimicked viral warts, as in the present case. The diagnosis of metastatic CD in the present case was not difficult because characteristic histopathological features were present, and a clinical history of CD was available. However, a few cases of genital swelling associated with granulomatous inflammation prior to a diagnosis of gastrointestinal CD have been documented. Therefore, granulomatous vasculitis and lymphangitis in the external genitals should be considered as potential indication of metastatic CD even in cases without a history of gastrointestinal CD.

Ishida, Mitsuaki; Iwai, Muneo; Yoshida, Keiko; Kagotani, Akiko; Okabe, Hidetoshi

2013-01-01

95

Paraganglioma of the vulva: a case report and review of the literature  

PubMed Central

Paraganglioma is a neuroendocrine neoplasm, which is extremely rare in the vulva and only one case has been reported. Here we present a case of vulvar paraganglioma in a 48-year-old woman and a literature review. The patient found a lump located in the genitals below the symphysis pubis 3 months before presentation when she complained that the lump was increasing in size. A 3.2 cm x 2.3 cm x 1.5 cm nodule was excised from subcutaneous soft tissue in the vulva. Microscopy showed a diversity of cell morphologies and structures in the rich vascular network of the tumor separated the chief cells into round cell nests (Zellballen pattern). Some areas of the tumor presented epithelioid and spindle-shaped cells with increased cell density and indistinct structural characteristics. Hyaline degeneration of collagen fibers or mucoid degeneration was found in tumor interstitium. Immunohistochemical staining showed diffused expression of synaptophysin in the chief cells, focal expression of S-100 protein in the sustentacular cells and high expression of CD34 in the vascular components. Based on morphological and immunohistochemical results, a rare paraganglioma of the vulva was diagnosed.

Liu, Yong-Qiao; Yue, Jun-Qiu

2013-01-01

96

Paraganglioma of the vulva: a case report and review of the literature.  

PubMed

Paraganglioma is a neuroendocrine neoplasm, which is extremely rare in the vulva and only one case has been reported. Here we present a case of vulvar paraganglioma in a 48-year-old woman and a literature review. The patient found a lump located in the genitals below the symphysis pubis 3 months before presentation when she complained that the lump was increasing in size. A 3.2 cm x 2.3 cm x 1.5 cm nodule was excised from subcutaneous soft tissue in the vulva. Microscopy showed a diversity of cell morphologies and structures in the rich vascular network of the tumor separated the chief cells into round cell nests (Zellballen pattern). Some areas of the tumor presented epithelioid and spindle-shaped cells with increased cell density and indistinct structural characteristics. Hyaline degeneration of collagen fibers or mucoid degeneration was found in tumor interstitium. Immunohistochemical staining showed diffused expression of synaptophysin in the chief cells, focal expression of S-100 protein in the sustentacular cells and high expression of CD34 in the vascular components. Based on morphological and immunohistochemical results, a rare paraganglioma of the vulva was diagnosed. PMID:24133606

Liu, Yong-Qiao; Yue, Jun-Qiu

2013-09-15

97

Loss in 3p and 4p and Gain of 3q Are Concomitant Aberrations in Squamous Cell Carcinoma of the Vulva  

Microsoft Academic Search

Neoplasm of the vulva is a rare malignancy accounting for <5% of all female genital-tract cancer. However, in recent years the incidence of vulva intraepithelial neoplasia, known to serve as a precursor to carcinoma, has increased in young women generating considerable interest in its pathogenesis. Genetic changes at the molecular level in precursor or invasive vulvar tumors are not well

Kowan J. Jee; Young Tak Kim; Kyu Rae Kim; Hy Sook Kim; Aalto Yan; Sakari Knuutila

2001-01-01

98

Sarcomatoid squamous cell carcinoma of the vulva expressing smooth muscle actin and S100 protein  

Microsoft Academic Search

Introduction  Vulvar sarcomatoid squamous cell carcinoma has been rarely reported.\\u000a \\u000a \\u000a \\u000a Methods  Case report and immunohistochemistry.\\u000a \\u000a \\u000a \\u000a Results  The author herein reports a peculiar vulvar tumor. An 87-year-old woman with hypertension presented with a vulvar tumor, and\\u000a admitted to our hospital. Gross examination showed an elevated tumor measuring 3 × 4 × 5 cm in the vulva near the urethra.\\u000a An excisional biopsy was taken, and it showed proliferation and

Tadashi Terada

2011-01-01

99

Treatment of angiokeratoma of the vulva with pulsed dye laser therapy.  

PubMed

Angiokeratoma of the vulva is relatively rare with few cases reported in the literature. The lesions are usually asymptomatic, but clinical presentations can include bleeding and vulval pruritus. Treatments for symptomatic cases include surgical excision, cryotherapy and argon or carbon dioxide laser therapy. We present a case series of patients who have been successfully treated with pulsed dye laser therapy. This was performed in the outpatient setting without the need for local anaesthesia. All patients had resolution of their symptoms. This treatment modality to our knowledge has not been reported in the literature. PMID:19929291

Oni, Georgette; Mahaffey, Peter

2010-02-01

100

Two distinct pathways to development of squamous cell carcinoma of the vulva.  

PubMed

Squamous cell carcinoma (SCC) accounts for approximately 95% of the malignant tumors of the vaginal vulva and is mostly found in elderly women. The future numbers of patients with vulvar SCC is expected to rise, mainly because of the proportional increase in the average age of the general population. Two different pathways for vulvar SCC have been put forth. The first pathway is triggered by infection with a high-risk-type Human Papillomavirus (HPV). Integration of the HPV DNA into the host genome leads to the development of a typical vulvar intraepithelial neoplasia (VIN), accompanied with overexpression of p14(ARF) and p16(INK4A). This lesion subsequently forms a warty- or basaloid-type SCC. The HPV vaccine is a promising new tool for prevention of this HPV related SCC of the vulva. The second pathway is HPV-independent. Keratinizing SCC develops within a background of lichen sclerosus (LS) through a differentiated VIN. It has a different set of genetic alterations than those in the first pathway, including p53 mutations, allelic imbalances (AI), and microsatellite instability (MSI). Further clinical and basic research is still required to understand and prevent vulvar SCC. Capsule. Two pathway for pathogenesis of squamous cell carcinoma of the value are reviewed. PMID:21188235

Ueda, Yutaka; Enomoto, Takayuki; Kimura, Toshihiro; Yoshino, Kiyoshi; Fujita, Masami; Kimura, Tadashi

2010-09-28

101

Radical Surgery for T1 and T2 Squamous Cell Carcinoma of the Vulva Through Separate Incisions  

Microsoft Academic Search

Objectives: The aim of the study was to retrospectively evaluate treatment results in patients with T1 and T2 vulvar carcinoma. Material and Method: The medical records of 46 patients with T1 and T2 SCC of the vulva undergoing radical excision of the tumor and groin node dissection at Chiang Mai University Hospital between January 1998 and December 2004 were reviewed.

Apichart Khobjai; Jatupol Srisomboon; Kittipat Charoenkwan; Chailert Phongnarisorn; Prapaporn Suprasert; Sitthicha Siriaree; Chalong Cheewakriangkrai; Charuwan Tantipalakorn; Chumnan Kietpeerakool

102

Giant Angiokeratoma of Fordyce over the Vulva in a Middle-Aged Woman: Case Report and Review of Literature  

PubMed Central

Angiokeratoma of Fordyce occurring over vulva is rare. Angiokeratoma of Fordyce commonly occurs in males over scrotum or penile shaft and presents as multiple verrucous reddish papules. They are usually asymptomatic and noticed accidentally. In the present article, we present and review the literature of giant angiokeratoma of Fordyce in middle-aged women due to its rarity.

Kudur, Mohan H; Hulmani, Manjunath

2013-01-01

103

Benign ulcer of the right colon clinically misdiagnosed as carcinoma: an additional case.  

PubMed

Benign solitary ulcer of the colon is an uncommon lesion that was originally described by Cruveilhier in 1832. Its aetiology remains unknown, and there are no pathognomonic lesions or symptoms. Diagnosis is made by exclusion; in fact, diseases such as specific infections (cytomegalovirus, campylobacter jejuni, entamoeba histolytica), common clinical conditions (acute appendicitis, diverticulitis, intestinal obstruction, inflammatory bowel disease), pharmacotherapy (non-steroidal anti-inflammatory medications, oral contraceptives, dicumarolic agents) and malignancies should be excluded. We describe the case of a 72-year-old patient admitted for acute bloody diarrhoea, originally misdiagnosed as carcinoma by colonscopy. The histological evaluation demonstrated a benign ulcerative lesion. PMID:22799054

Ambrosio, M R; Ginori, A; Mourmouras, V; Mastrogiulio, M G; Barone, A; Rocca, B J

2012-02-01

104

Misdiagnosing ventricular tachycardia in patients with underlying conduction disease and similar sinus and tachycardia morphologies.  

PubMed Central

Six patients presented with wide-complex tachycardias with QRS morphologies similar to those seen on their electrocardiograms that showed normal sinus rhythms. During normal sinus rhythm, each patient had an underlying intraventricular conduction abnormality or bundle branch block. Despite the similarity of the QRS complexes to those seen during sinus rhythm, the tachycardias subsequently proved to be ventricular in origin in each patient. It is important not to misdiagnose these disorders as supraventricular tachycardia as an erroneous diagnosis may result in inappropriate management. Images

Halperin, B. D.; Kron, J.; Cutler, J. E.; Kudenchuk, P. J.; McAnulty, J. H.

1990-01-01

105

Multifocal atrial tachycardia (MAT). The misdiagnosed atrial arrhythmia of old age.  

PubMed

The clinical and electrocardiographic features of multifocal atrial tachycardia are described and illustrated by nine examples. It is almost entirely seen in later life and is often misdiagnosed as atrial fibrillation. It is associated with a high mortality and the majority of the cases described here reverted to sinus rhythm. Little attention has been so far paid to this important arrhythmia in the elderly in standard textbooks of cardiology. The literature is reviewed and management discussed. It is not a rare supreventricular tachycardia in the aged and many examples may be not diagnosed. It merits further study in relation to unanswered questions. PMID:892451

Clark, A N

1977-01-01

106

Extended hemangioma from pharynx to esophagus that could be misdiagnosed as an esophageal varix on endoscopy.  

PubMed

Giant hemangioma in the neck and head is an uncommon vascular neoplasm and has an unpredictable clinical behavior. We report a hemangioma that extended from the pharynx to the esophagus that could have been misdiagnosed as an esophageal varix. A 42-year-old man with dilated varices-like vessels on his esophagus that were incidentally detected by endoscopy was referred to our hospital for further evaluation. On re-examined endoscopy, multiple vascular dilatations were noted in the pharynx, expanding into the esophagogastric junction. These dilatations looked like esophageal varices that are found in patients with liver cirrhosis. There was no significant abnormality, including liver cirrhosis, on the abdomino-pelvic computed tomography scan. On the endoscopic esophageal biopsy, dilatedsubmucosal blood vessels were diagnosed as hemangioma. In consultation with an otorhinolaryngologist for evaluation of the risk of hemangioma, it was determined that the hemangioma was not dangerous to the patient as long as it did not cause hoarseness, dyspnea or dysphagia. We planned regular 6-month follow ups. We report a case of extended hemangioma that could possibly have been misdiagnosed as an esophageal varix on endoscopy. Even if head and neck hemangioma is uncommon, careful consideration during endoscopy is required to avoid the misdiagnosis of varices or hemangioma. PMID:24164602

Won, Jong Won; Lee, Hyun Woong; Yoon, Kyu Hyun; Yang, Suh Yoon; Moon, In Seok; Lee, Tae Jin

2012-12-06

107

Pedunculated Angiomyofibroblastoma of the Vulva: Case Report and Review of the Literature  

PubMed Central

Angiomyofibroblastoma (AMFB) is a rare benign mesenchymal tumour that occurs almost exclusively in the vulvovaginal region of women but can also occur occasionally in the inguinoscrotal region of men. It is a well-circumscribed lesion that clinically is often thought to represent a Bartholin's gland cyst and usually does not form a pedunculated mass. To our knowledge, only five cases of vulvar AMFB with pedunculated mass have been reported in the English literature and all cases involving the labia majora and middle-aged women. We report the first case of pedunculated AMFB of the vulva occurring in a young woman of 21 years old and involving the left labia minora. After excluding the most common diseases, pedunculated AMFB should be part of differential diagnosis in the workup of any pedunculated vulvar mass even in young women with a lesion involving the labia minora. We reviewed the literature and summarized all reported cases.

Giannella, Luca; Costantini, Matteo; Mfuta, Kabala; Cavazza, Alberto; Cerami, Lillo Bruno; Gardini, Giorgio; Boselli, Fausto

2011-01-01

108

Proximal-type epithelioid sarcoma of the vulva with INI1 diagnostic utility.  

PubMed

Proximal epithelioid sarcoma (PES) is an extremely uncommon neoplasm of the vulva with an aggressive behavior. Recently, these authors experienced a case of proximal-type ES in a 41-year-old woman who was admitted for a rapidly growing mass in the right mons pubis. An about-1-cm-sized mass was initially noticed one and a half years earlier. The excised mass, however, was 8 cm in greatest dimension and was relatively well circumscribed. The cut surface was trabeculated, with multifocal hemorrhages and necroses. Microscopically, the tumor consisted of epithelioid rhabdoid cells with vesicular nuclei, large prominent nucleoli, and cytoplasmic eosinophilic globules comparted by thin, fibrous septae. The main differential diagnoses included PES, other sarcomas with epithelioid cells, malignant melanoma, and sarcomatoid carcinoma. The tumor cells were diffusely positive for vimentin and EMA; focally positive for cytokeratin; and negative for CK5/6, CD34, S-100 protein, desmin, and myogenin. INI1 (hSNF5/SMARCB1, a member of the SW1/SNF chromatin remodeling complex located on chromosome 22q11.2) staining clearly showed loss of expression in the tumor cells. Recent studies reported that some ESs also showed INI1 inactivation, as characteristically seen in malignant rhabdoid tumors of infancy. Reported herein is the diagnostic utility of INI-1 on PES and the possible relationship between PES and malignant rhabdoid tumor of the soft tissue, besides a collective review of the reported cases of PES of the vulva and of the current case. PMID:21724432

Kim, Hyun-Jung; Kim, Myoung-Hwan; Kwon, Jieun; Kim, Jung Yeon; Park, Kyeongmee; Ro, Jae Y

2011-07-02

109

Misdiagnosing cystic fibrosis in the era of gene analysis: case reports.  

PubMed

We present a scenario of how gene analysis plays a confusing role in the diagnosis of cystic fibrosis (CF). One of the two siblings we are presenting here was initially misdiagnosed as having CF, based on the two CF gene mutations identified by gene analysis. A CF gene study on the other sibling years later, however, led to further investigation and eventually to a change of diagnosis. As interesting and important as gene analysis is in CF, one must always look at each patient in the big picture. Included in the picture, in addition to the state-of-the-art genotype, is the phenotype, or (to simplify) the back-to-basic clinical manifestations. PMID:15678508

Moser, Chuanpit; Nussbaum, Eliezer; Thompson, Rohan

2005-04-01

110

Preoperative chemo-radiation for carcinoma of the vulva with N2\\/N3 nodes: a gynecologic oncology group study  

Microsoft Academic Search

Purpose: To determine if patients with carcinoma of the vulva, with N2\\/N3 lymph nodes, could undergo resection of the lymph nodes and primary tumor following preoperative chemo-radiation.Methods and Materials: Fifty-two patients were entered in the study, but six patients did not meet the criteria of the protocol and were excluded. The remaining 46 patients are the subject of this report.

Gustavo S Montana; Gillian M Thomas; David H Moore; Angelika Saxer; Charles E Mangan; Samuel S Lentz; Hervy E Averette

2000-01-01

111

Atypical vitelliform macular dystrophy misdiagnosed as chronic central serous chorioretinopathy: case reports  

PubMed Central

Background To report two cases of atypical vitelliform macular dystrophy misdiagnosed as chronic central serous chorioretinopathy. Case presentation Two patients with incidentally discovered abnormalities of the retina without specific symptoms were referred to our hospital for consultation. Bilateral macula atrophic lesions were observed and optical coherence tomography revealed serous retinal detachment in the macula. Fluorescein angiography showed multiple leakages around the central hypofluorescent area and indocyanine green angiography showed partially dilated choroidal vessels. Fundus autofluorescence (FAF) showed a decreasing pattern of autofluorescence in the subretinal fluid area, and increasing autofluorescence at the border of the serous retinal detachment. Both patients were diagnosed with chronic central serous chorioretinopathy. Photodynamic therapy and intravitreal bevacizumab injection were administered for engorged choroidal vessels during follow-up, but neither patient showed improvement in symptoms or ophthalmologic findings. Based on re-evaluation by fundus photography, optical coherence tomography, fluorescein angiography, and comparison of the results of FAF with the first visit, vitelliform macular dystrophy was suspected and a definite diagnosis was made by electrooculography and genetic testing. Conclusion In patients with continuous serous retinal detachment without response to photodynamic therapy or intravitreal bevacizumab injection, careful fundus exam and FAF can be used to diagnose atypical vitelliform macular dystrophy.

2012-01-01

112

Chemotherapy-induced peripheral neurotoxicity can be misdiagnosed by the National Cancer Institute Common Toxicity scale.  

PubMed

The assessment of chemotherapy-induced peripheral neurotoxicity (CIPN) is still uncertain as several of the most frequently used scales do not rely on a formal neurological evaluation and depend on patients' reports and examiners' interpretations. The aim of this study was to compare the assessment of CIPN using the National Cancer Institute Common Toxicity Criteria (NCI-CTC) scale and a formal neurological assessment scored with the Total Neuropathy Score (TNS, i.e., a composite scale designed to grade the impairment in neuropathy patients) to identify possible discrepancies in the diagnosis. In this prospective study, 155 patients treated with cisplatin/carboplatin or with paclitaxel/docetaxel and CIPN were examined in a collaborative oncological/neurological multi-center trial using the NCI-CTC scale and the TNS; the results were then extensively compared. We evidenced that the TNS allows possible misdiagnosed neuropathies to be revealed. In fact, the NCI-CTC evaluation performed by experienced examiners overestimated the occurrence of motor neuropathy, possibly because of the presence of confounding factors (e.g., fatigue, depression, cachexia), which might be difficult to be ruled out without a formal neurological examination. This study strongly indicates that a more formal neurological assessment of patients with CIPN than that achievable with the common toxicity scales (e.g., NCI-CTC) is advisable. PMID:22003937

Frigeni, Barbara; Piatti, Marialuisa; Lanzani, Francesca; Alberti, Paola; Villa, Patrizia; Zanna, Claudio; Ceracchi, Maurizio; Ildebrando, Massimo; Cavaletti, Guido

2011-09-01

113

Fetal t(5p;21q) misdiagnosed as monosomy 21: A plea for in situ hybridization studies  

SciTech Connect

We report a case of 45,XY,-5,-21,+der (5)t(5;21) (p13 or p14;q11.2 or q21) that was prenatally misdiagnosed as complete monosomy 21 and terminated at 24 weeks of gestation. Subsequent fluorescence in situ hybridization studies with a chromosome 21 painting probe documented the cryptic unbalanced translocation. 17 refs., 2 figs., 1 tab.

Gill, P.; Uhrich, S.; Cheng, E.; Disteche, C. [Univ. of Washington Medical Center, Seattle, WA (United States)

1994-10-01

114

A 60Year Meta-Analysis of Tick Paralysis in the United States: A Predictable, Preventable, and Often Misdiagnosed Poisoning  

Microsoft Academic Search

Tick paralysis (TP) is a neurotoxic poisoning primarily afflicting young girls in endemic regions. Recent case series of TP\\u000a have described increasing misdiagnoses of TP as the Guillain–Barré syndrome (GBS). A meta-analysis of the scientific literature\\u000a was conducted using Internet search engines to assess the evolving epidemiology of TP. Fifty well-documented cases of TP were\\u000a analyzed over the period 1946–2006.

James Henry Diaz

2010-01-01

115

Fetal t(5p;21q) misdiagnosed as monosomy 21: A plea for in situ hybridization studies  

Microsoft Academic Search

We report a case of 45,XY,-5,-21,+der (5)t(5;21) (p13 or p14;q11.2 or q21) that was prenatally misdiagnosed as complete monosomy 21 and terminated at 24 weeks of gestation. Subsequent fluorescence in situ hybridization studies with a chromosome 21 painting probe documented the cryptic unbalanced translocation. 17 refs., 2 figs., 1 tab.

Prabhcharan Gill; Stefanie Uhrich; E. Cheng; C. Disteche

1994-01-01

116

An inversion in the wiring of an intercellular signal: evolution of Wnt signaling in the nematode vulva.  

PubMed

Signal transduction pathways are largely conserved throughout the animal kingdom. The repertoire of pathways is limited and each pathway is used in different intercellular signaling events during the development of a given animal. For example, Wnt signaling is recruited, sometimes redundantly with other molecular pathways, in four cell specification events during Caenorhabditis elegans vulva development, including the activation of vulval differentiation. Strikingly,a recent study finds that Wnts act to repress vulval differentiation in the nematode Pristionchus pacificus,1 demonstrating evolutionary flexibility in the use of intercellular signaling pathways. PMID:16015606

Félix, Marie-Anne

2005-08-01

117

Risk factors for invasive squamous cell carcinoma of the vulva and vagina--population-based case-control study in Denmark.  

PubMed

The etiology of vulvar and vaginal squamous cell carcinoma (VV-SCC) has received little attention. A total of 182 women with invasive VV-SCC (116 with VV-SCC(vulva), 66 with VV-SCC(vagina)), 164 uterine corpus cancer controls and 518 population controls were interviewed in a population-based case-control study in Denmark, and 87 (48%) of the VV-SCC cases had tissue samples examined for human papillomavirus (HPV) DNA using the GP5+/6+ PCR-EIA assay and subsequent reverse line blotting for HPV typing. Logistic regression-derived odds ratios with 95% confidence intervals served as relative risks. Cervical cancer-associated high-risk HPVs (hrHPVs) were detectable in most (89%) examined cases of VV-SCC(vagina) and in half (50%) of cases of VV-SCC(vulva) (p < 0.001). In site-specific multivariate logistic regression analyses, statistically significant risk factors for both VV-SCC(vulva) and VV-SCC(vagina) included measures of hrHPV exposure (anogenital warts for VV-SCC(vulva); cervical neoplasia and poor genital hygiene for VV-SCC(vagina)), tobacco smoking and alcohol consumption. Furthermore, socioeconomic variables (marital status and years at school) were associated with risk of VV-SCC(vulva). Comparing hrHPV-positive and hrHPV-negative VV-SCCs in polytomous logistic regression analysis revealed that tobacco smoking and cervical neoplasia were significant risk factors only for hrHPV-positive VV-SCCs. Our study shows that VV-SCC(vulva) and VV-SCC(vagina) share measures of prior hrHPV exposure, tobacco smoking and alcohol consumption as statistically significant risk factors. HPV vaccination programs aimed at reducing the burden of cervical cancers are likely to also provide considerable protection against VV-SCCs. PMID:18348142

Madsen, Birgitte S; Jensen, Helle L; van den Brule, Adriaan J C; Wohlfahrt, Jan; Frisch, Morten

2008-06-15

118

Platelet-type von Willebrand disease: a rare, often misdiagnosed and underdiagnosed bleeding disorder.  

PubMed

Platelet-type von Willebrand disease (PT-VWD) is an autosomal dominant rare bleeding disorder characterized by hyperresponsive platelets. This inherent platelet function defect is due to a gain-of-function mutation within the GP1BA gene coding for the platelet surface glycoprotein Ib alpha protein, the receptor for the adhesive protein von Willebrand factor (VWF). The defect results in excessive and unnecessary platelet-VWF interaction with subsequent removal of the hemostatically efficient high molecular weight VWF as well as platelets from the circulation, leading to thrombocytopenia and bleeding diathesis. Patients with PT-VWD present with mild to moderate mucocutaneous bleeding, which becomes more pronounced during pregnancy and following aspirin ingestion or drugs that have antiplatelet activity. Laboratory testing shows low VWF:ristocetin cofactor and low or normal VWF:antigen and characteristically an enhanced ristocetin-induced platelet agglutination (RIPA). These laboratory features are also indicators of the closely similar and more common bleeding disorder type 2B VWD. Simplified RIPA mixing assays, cryoprecipitate challenge, and flow cytometry can differentiate between the two disorders. However, the gold standard is to identify mutations within the VWF gene (indicating type 2B VWD) or the platelet GP1BA gene (confirming PT-VWD). Treatment is based on making a correct diagnosis of PT-VWD where platelet concentrates instead of VWF/factor VIII preparations should be administered. A recent fairly large retrospective/prospective registry-based international study showed that PT-VWD is very rare, likely to be misdiagnosed as type 2B VWD or idiopathic thrombocytopenic purpura, and represents 15% of type 2B VWD diagnoses. PMID:22102188

Othman, Maha

2011-11-18

119

[Nocturnal frontal lobe epilepsy is often misdiagnosed as sleep disorders in children: a case series].  

PubMed

INTRODUCTION. We present a series of children who underwent a video-polysomnographic recording at our Sleep and Epilepsy Unit, who received a diagnosis of nocturnal frontal lobe epilepsy (NFLE). AIMS. To describe electroclinical and video polygraphic features of paediatric NFLE that differentiate this condition from other sleep disorders that overlap and mimic the sleep motor and autonomic events of NFLE. PATIENTS AND METHODS. The inclusion criterion was that the patients have their first video-EEG-PSG recording in our laboratory. RESULTS. Twenty-four out of 190 children were diagnosed with NFLE (group 1); while 166 had other sleep disorders (group 2). Among children diagnosed with NFLE, seven were referred for sleep-disordered breathing, seven for parasomnias, two for insomnia, two for hypersomnia, and one for periodic limb movements, while five were referred for epilepsy. In group 1, perinatal history was normal in most cases (21 out of 24) and a familiar history of epilepsy was found in four cases. Sleep-disordered breathing was diagnosed as a comorbid condition in four children. Standard EEG was normal in 21 cases. Interictal EEG showed epileptic discharges in four cases, while ictal EEG was expressed by a rhythmic theta activity preceded by an arousal and/or a short background desynchronization, movement artifacts, and autonomic changes. All seizures, repeated highly stereotyped motor events, were followed by stage shifts and/or a postural change and, by short awakenings. CONCLUSIONS. We found a high percentage of children with NFLE, often misdiagnose or associated with other sleep disorders, which may be a trigger for nocturnal seizures. PMID:23440753

Miano, Silvia; Peraita-Adrados, Rosa

2013-03-01

120

Reduced E-cadherin expression correlates with disease progression in Paget's disease of the vulva but not Paget's disease of the breast  

Microsoft Academic Search

The growth and metastasis of many cancers is due in part to loss of cell–cell adhesion. E-cadherin, plakoglobin and ?-catenin are important in cell adhesion. Our aim was to examine the presence of these molecules in Paget's disease of the vulva and Paget's disease of the breast, and to correlate any differences in their expression with the presence of invasive

Patricia E Ellis; Salvador Diaz Cano; Mark Fear; David P Kelsell; Lucy Ghali; Julie C Crow; Christopher W Perrett; Allan B MacLean

2008-01-01

121

Validity of the zygosity questionnaire and characteristics of zygosity-misdiagnosed twin pairs in the Healthy Twin Study of Korea.  

PubMed

Determining valid zygosity is a basic and important requirement in a twin study, because misdiagnosing zygosity leads to biased results. The Healthy Twin Study has collected data from adult like-sex twins and their families since 2005. In the study, a questionnaire to determine zygosity was developed comprising four questions; one concerning the degree of resemblance, and three concerning the degree of confusion by the resemblance. Among 2,761 individuals (624 twin pairs) of twin and their families, 406 pairs of twins (mean age 38.3, 63.5% women) with both questionnaire and genotype information were selected to examine the validity of the zygosity questionnaire using 16 short tandem repeat markers. We first determined individual zygosity including undetermined category, and then decided the zygosity of a twin pair using a decision tree. Sensitivity of questionnaire diagnosis was 98.8% for monozygotic (MZ) and 88.9% for dizygotic (DZ) twins, and positive predictive value was 97.2% for MZ and 95.0% for DZ. When we compared correctly and wrongly diagnosed twin pairs, misdiagnosed DZ twins (nine pairs) showed striking similarity in stature or obesity even exceeding that of true MZ twins. Our finding suggests that a parsimonious questionnaire method of diagnosing the zygosity will be useful, and adding physical or physiological measurements to a questionnaire of zygosity diagnosis will either confound the correct diagnosis or reduce the efficiency of the study compared with using questionnaire alone or with introducing genotyping. PMID:20477720

Song, Yun-Mi; Lee, Donghun; Lee, Mi Kyoung; Lee, Kayoung; Lee, Hee Jung; Hong, Eun Jung; Han, Bokghee; Sung, Joohon

2010-06-01

122

Thyroid-stimulating hormone elevation misdiagnosed as subclinical hypothyroidism following non-convulsive status epilepticus: a case report  

PubMed Central

Introduction Non-convulsive status epilepticus is a form of epileptic seizure that occurs without convulsions. Recent reviews suggest that the diagnosis of non-convulsive status epilepticus remains difficult. Here, we report the case of a patient with thyroid-stimulating hormone elevation misdiagnosed as subclinical hypothyroidism following non-convulsive status epilepticus. Case presentation Our patient was a 68-year-old Japanese woman. The results of endocrine testing after her first episode of non-convulsive status epilepticus suggested latent subclinical hypothyroidism: she had elevated thyroid-stimulating hormone with normal levels of free tri-iodothyronine and free thyroxine. On examination, a diagnosis of thyroid disorder was not supported by other test results and our patient remained untreated. A follow-up examination revealed that her thyroid-stimulating hormone levels had spontaneously normalized. When she consulted another doctor for confusion, the transient increase in thyroid-stimulating hormone levels following non-convulsive status epilepticus was mistaken for subclinical hypothyroidism, and unfortunately treated with levothyroxine. Our patient then experienced levothyroxine-induced non-convulsive status epilepticus. Conclusions In this report, we suggested possible mechanisms for latent hypothyroid-like hormone abnormality following epileptic seizures and the possibility of provoking epileptic seizures by administering levothyroxine for misdiagnosed subclinical hypothyroidism.

2011-01-01

123

Ulcus vulvae acutum in a 13-year-old girl after influenza A infection.  

PubMed

A 13-year-old otherwise healthy premenarchal girl presented with acute onset of painful vulvar ulcerations. One day before developing vulvar ulcerations, she experienced flu-like symptoms, including a low-grade fever, cough, sore throat, and myalgia. Results of a throat swab were positive for influenza A infection (polymerase chain reaction [PCR] assay), and the patient was treated with oseltamivir. The patient's constitutional symptoms improved slightly, but within 2 days after her initial presentation, she returned to her primary care provider and described 24 hours of dysuria and vulvar swelling. She had a history of herpes labialis (cold sores) and rare episodes of minor oral aphthae (canker sores) that occurred less than twice a year. The patient denied a history of sexual activity, sexual abuse, or physical trauma. Physical examination showed ulceration and swelling of the labia minora, and the patient received an empiric dose of acyclovir (200 mg 4 times daily) for presumed autoinoculated herpes simplex virus (HSV) infection. An ulcer swab was performed, and urinalysis revealed no evidence of infection. Two days later, the patient presented to the emergency department with increasing vulvar pain and vaginal discharge. The previous ulcer swab findings were negative for HSV (PCR assay), and consequently, acyclovir was discontinued after 1 day of therapy. She received topical viscous lidocaine and an empiric dose of oral fluconazole. The lidocaine provided temporary symptomatic relief. Results of DNA amplification studies were negative for Chlamydia trachomatis and Neisseria gonorrhoeae. A potassium hydroxide preparation was negative for fungi, and an ulcer swab for bacterial culture revealed usual flora. Of note, the PCR assay for Epstein-Barr virus was not performed on ulcer cells. The patient was referred to the department of dermatology, and results of a physical examination showed copious white mucoid discharge and a 2-cm ulceration of the left labia minora (Figure, panel A). Two smaller pinpoint ulcerations and swelling of the left labia minora were also noted. The lesions were clinically indistinguishable from the genital aphthous ulcers of patients with complex aphthosis (recurrent, severe aphthous ulcers on oral or genital mucosa). A diagnosis of ulcus vulvae acutum was made, and treatment was started with clobetasol 0.05% ointment (4 times daily) and lidocaine gel as needed. Four days later, the patient reported marked symptomatic improvement. Physical examination showed near resolution of the large vulvar ulceration (Figure, panel B). The patient tapered use of clobetasol ointment over the next several days until the ulcerations healed completely. Two months after her initial episode, the patient again had 3 small vulvar erosions after symptoms that included low-grade fever, malaise, and vomiting. She did not receive oseltamivir for this illness; clobetasol ointment was applied 4 times daily, and the vulvar erosions ameliorated within a few days. Her constitutional symptoms resolved without treatment. The patient has not experienced any further episodes of vulvar ulcerations in the 18 months after the most recent treatment. PMID:18327008

Wetter, David A; Bruce, Alison J; MacLaughlin, Kathy L; Rogers, Roy S

124

Fatal Case of Brucellosis Misdiagnosed in Early Stages of Brucella suis Infection in a 46-Year-Old Patient with Marfan Syndrome  

PubMed Central

We report a fatal case of Brucella suis endocarditis initially misdiagnosed by automated identification systems as Ochrobactrum anthropi infection in a patient with a history of Marfan syndrome and recreational feral swine hunting. This report emphasizes the need to consider brucellosis as a part of the differential diagnosis of acute febrile illness, particularly in patients with known risk of exposure.

Carrington, M.; Choe, U.; Ubillos, S.; Stanek, D.; Campbell, M.; Wansbrough, L.; Lee, P.; Churchwell, G.; Rosas, K.; Zaki, S. R.; Drew, C.; Paddock, C. D.; DeLeon-Carnes, M.; Guerra, M.; Hoffmaster, A. R.; Tiller, R. V.

2012-01-01

125

DNA ploidy and expression of p53 and C-erbB-2 in extramammary Paget's disease of the vulva.  

PubMed

Clinical data were retrieved from the hospital records of 34 patients with Paget's disease of the vulva treated from 1972 to 1990. Flow-cytometric (FCM) DNA measurements and p53 and c-erbB-2 immunostaining were performed on paraffin-embedded samples. Five patients had an underlying adenocarcinoma and 29 intraepithelial disease (IEP). Twenty-seven patients with IEP underwent surgery. The surgical margins were positive in 15 patients, negative in 10, and not evaluable in 2. The tumor was diploid in 15 patients, nondiploid in 11, and not evaluable in 1. Eight patients recurred, 6/15 (40%) with positive and 2/10 (20%) with negative margins. One patient with positive margins was never disease-free. Recurrence was seen in 6/11 (55%) patients with nondiploid tumors, 4 with positive and 2 with negative margins. Two of 15 (13%) patients with diploid tumors recurred/persisted, both with positive margins. None of the 6 patients with diploid tumors and negative margins recurred. p53 and c-erbB-2 were found negative in all but 4 patients. Tumor nondiploidy was associated with an increased risk of recurrence irrespective of surgical radicality. p53 and c-erbB-2 seemed to play no role in the pathogenesis or prognosis. PMID:8995553

Scheistrøen, M; Tropé, C; Kaern, J; Pettersen, E O; Alfsen, G C; Nesland, J M

1997-01-01

126

Easily misdiagnosed delayed metastatic intraspinal extradural melanoma of the lumbar spine: A case report and review of the literature  

PubMed Central

Metastatic melanoma of the spine usually occurs as vertebral metastatic melanoma or intramedullary spinal cord metastatic melanoma. The present study reports a case of easily misdiagnosed delayed metastatic intraspinal extradural melanoma of the lumbar spine. A 67-year-old female patient presented with lower back pain accompanied by progressive intermittent claudication. Magnetic resonance imaging (MRI) suggested compression of the lumbar spinal cord caused by an extradural mass. The mass showed T2-hypointensity, T1-hypointensity and slight enhancement following a gadolinium-contrast injection. The patient had been diagnosed with a vulvar melanoma 13 years previously and had also undergone a resection of this tumor. A current diagnosis of a lumbar stenosis resulting from hypertrophy of the ligamentum flavum was suspected. However during corrective surgery, a dark gray solid mass was observed. An L3 laminectomy and removal of the tumor was performed. The tumor was confirmed to be a malignant melanoma by histopathological investigation. The patient was treated with radiotherapy and immunotherapy. At the final 13-month follow-up, the patient showed no signs of recurrence. It may be concluded that an early diagnosis of metastatic melanoma was prevented by delayed metastasis, the location of the mass and its unusual appearance in MRI scans. In such cases, early surgical removal and an appropriate comprehensive treatment are critical for patient survival. These observations suggest that caution should be used in the diagnosis of similar cases.

SUN, LIN; SONG, YUEMING; GONG, QUAN

2013-01-01

127

Different DNA damage and cell cycle checkpoint control in low- and high-risk human papillomavirus infections of the vulva.  

PubMed

Human papillomavirus (HPV) infections may result in benign hyperplasia, caused by low-risk HPV types, or (pre)malignant lesions caused by high-risk HPV types. The molecular basis of this difference in malignant potential is not completely understood. Here, we performed gene profiling of different HPV infected vulvar tissues (condylomata acuminata (n = 5), usual type vulvar intraepithelial neoplasia (uVIN) (n = 9)) and control samples (n = 14) using Affymetrix Human U133A plus 2 GeneChips. Data were analyzed using OmniViz®, Partek® and Ingenuity® Software. Results were validated by real-time RT-PCR and immunostaining. Although similarities were observed between gene expression profiles of low- and high-risk HPV infected tissues (e.g., absence of estrogen receptor in condylomata and uVIN), high-risk HPV infected tissues showed more proliferation and displayed more DNA damage than tissues infected with low-risk HPV. These observations were confirmed by differential regulation of cell cycle checkpoints and by increased expression of DNA damage-biomarkers p53 and ?H2AX. Furthermore, FANCA, FANCD2, BRCA1 and RAD51, key players in the DNA damage response, were significantly upregulated (p < 0.05). In addition, we compared our results with publicly available gene expression profiles of various other HPV-induced cancers (vulva, cervix and head-and-neck). This showed p16(INK4a) was the most significant marker to detect a high-risk HPV infection, but no other markers could be found. In conclusion, this study provides insight into the molecular basis of low- and high-risk HPV infections and indicates two main pathways (cell cycle and DNA damage response) that are much stronger affected by high-risk HPV as compared to low-risk HPV. PMID:21815142

Santegoets, Lindy A M; van Baars, Romy; Terlou, Annelinde; Heijmans-Antonissen, Claudia; Swagemakers, Sigrid M A; van der Spek, Peter J; Ewing, Patricia C; van Beurden, Marc; van der Meijden, Willem I; Helmerhorst, Theo J M; Blok, Leen J

2011-08-30

128

Lymphatic Mapping and Sentinel Lymph Node Biopsy in Women With Squamous Cell Carcinoma of the Vulva: A Gynecologic Oncology Group Study  

PubMed Central

Purpose To determine the safety of sentinel lymph node biopsy as a replacement for inguinal femoral lymphadenectomy in selected women with vulvar cancer. Patients and Methods Eligible women had squamous cell carcinoma, at least 1-mm invasion, and tumor size ? 2 cm and ? 6 cm. The primary tumor was limited to the vulva, and there were no groin lymph nodes that were clinically suggestive of cancer. All women underwent intraoperative lymphatic mapping, sentinel lymph node biopsy, and inguinal femoral lymphadenectomy. Histologic ultra staging of the sentinel lymph node was prescribed. Results In all, 452 women underwent the planned procedures, and 418 had at least one sentinel lymph node identified. There were 132 node-positive women, including 11 (8.3%) with false-negative nodes. Twenty-three percent of the true-positive patients were detected by immunohistochemical analysis of the sentinel lymph node. The sensitivity was 91.7% (90% lower confidence bound, 86.7%) and the false-negative predictive value (1-negative predictive value) was 3.7% (90% upper confidence bound, 6.1%). In women with tumor less than 4 cm, the false-negative predictive value was 2.0% (90% upper confidence bound, 4.5%). Conclusion Sentinel lymph node biopsy is a reasonable alternative to inguinal femoral lymphadenectomy in selected women with squamous cell carcinoma of the vulva.

Levenback, Charles F.; Ali, Shamshad; Coleman, Robert L.; Gold, Michael A.; Fowler, Jeffrey M.; Judson, Patricia L.; Bell, Maria C.; De Geest, Koen; Spirtos, Nick M.; Potkul, Ronald K.; Leitao, Mario M.; Bakkum-Gamez, Jamie N.; Rossi, Emma C.; Lentz, Samuel S.; Burke, James J.; Van Le, Linda; Trimble, Cornelia L.

2012-01-01

129

Cancer of the Vulva  

MedlinePLUS

... showing cancer trends over time. Geographic Information Systems (GIS) Portal Interactive mapping and visualization of cancer related ... Histology Rules Software & Services SEER*RX - Interactive Drug Database SEER Abstracting Tool (SEER*Abs) Data Documentation & Variable ...

130

Challenging the concept of microinvasive carcinoma of the vulva: report of a case with regional lymph node recurrence and review of the literature  

PubMed Central

Background It is widely accepted that vulvar carcinoma with a depth of invasion of less than one millimeter is sufficiently treated by vulvectomy or wide local excision without inguinal lymphadenectomy. Case presentation However, a patient with inguinal lymph node recurrence 21 months after radical vulvectomy for stage IA squamous cell carcinoma was observed. Conclusion According to a review of the literature, there are five additional cases of metastasizing vulvar cancer with a depth of invasion of less than one millimeter. Therefore, the definition of microinvasive carcinoma of the vulva based on depth of invasion alone may not be as reliable as previously thought and does not rule out inguinal lymph node involvement or recurrence. Consequently, the necessity of inguinal node dissection for microinvasive carcinoma needs to be discussed on an individual basis taking into account the age of the patient as well as the potential morbidity of extended surgery.

Sidor, Jutta; Diallo-Danebrock, Raihana; Eltze, Elke; Lelle, Ralph J

2006-01-01

131

[Paget disease of the vulva: resolution after local treatment with imiquimod--report of a case and review of the literature].  

PubMed

Paget disease is a rare disorder of the skin of the vulva, comprising less than 1% of vulvar neoplasms. Surgical excision is considered the standard of care. While the invasive variant of Paget disease is rare, frequent local recurrences from non-invasive disease, which are inoperable, constitute a major clinical problem. In this article we report on a 71-year-old patient with recurrent disease treated successfully with imiquimod cream. Symptoms such as local itching subsided shortly after initiation of treatment. Four weeks later, first signs of resolution could be demonstrated colposcopically. Within 8 weeks, complete clinical remission was achieved. Thus, topical imiquimod is not only effective as treatment of vulvar intraepithelial neoplasia, but may also be used for selected patients with recurrent Paget disease as an alternative to repeat surgical interventions. PMID:20530949

Bertozzi, Serena; Londero, Ambrogio P; Fruscalzo, Arrigo; Marchesoni, Diego; Lellé, R J

2010-05-19

132

Human Papillomavirus Genotyping and E6/E7 mRNA Expression in Greek Women with Intraepithelial Neoplasia and Squamous Cell Carcinoma of the Vagina and Vulva  

PubMed Central

A large proportion of vaginal and vulvar squamous cell carcinomas (SCCs) and intraepithelial neoplasias (VAIN and VIN) are associated with HPV infection, mainly type 16. The purpose of this study was to identify HPV genotypes, as well as E6/E7 mRNA expression of high-risk HPVs (16, 18, 31, 33, and 45) in 56 histology samples of VAIN, VIN, vaginal, and vulvar SCCs. HPV was identified in 56% of VAIN and 50% of vaginal SCCs, 71.4% of VIN and 50% of vulvar SCCs. E6/E7 mRNA expression was found in one-third of VAIN and in all vaginal SCCs, 42.9% of VIN and 83.3% of vulvar SCCs. Our data indicated that HPV 16 was the commonest genotype identified in VAIN and VIN and the only genotype found in SCCs of the vagina and vulva. These findings may suggest, in accordance with other studies, that mRNA assay might be useful in triaging lesions with increased risk of progression to cancer.

Tsimplaki, Elpida; Argyri, Elena; Michala, Lina; Kouvousi, Maria; Apostolaki, Aikaterini; Magiakos, George; Papassideri, Issidora; Panotopoulou, Efstathia

2012-01-01

133

Ectopic Cervical Thymoma: A Report of Two Cases of a Rare Entity Frequently Misdiagnosed on Fine Needle Aspiration Cytology and Frozen Section  

PubMed Central

Ectopic cervical thymoma (ECT) is a rare tumor that is frequently misdiagnosed on fine needle aspiration cytology and frozen section. Using conventional light microscopy and immunohistochemistry, we characterized the only two cases of ECT found in our institutional files over a period of 20 years. Both tumors were classified as type AB-thymoma. Neoplastic cells expressed cytokeratins but not CD5. Non-neoplastic T-lymphocytes were positive for CD3 and CD5. Lymphocytes expressed CD1a in only one case. One tumor breached the capsule and had positive surgical margins. For this patient, adjuvant radiotherapy was given. The other patient has had an uneventful follow-up for 20 years with no other therapy than surgery. Both cases of ECT showed identical histomorphological and immunohistochemical features of type AB-thymomas originating in the thymus. Short follow-up precludes conclusion on the implication of positive margins in conjunction with adjuvant radiotherapy for one of the patients presented herein.

Yan, Benedict; Lim, Diana

2010-01-01

134

Pigmented lesions of the vulva.  

PubMed

Approximately one of every 10 women has a pigmented vulvar lesion. Given the risk of melanomas and pigmented vulvar intraepithelial neoplasia (squamous cell carcinoma in situ), proper evaluation of vulvar pigmented lesions is critical. Most vulvar lesions are benign; however, vulvar lesions grossly, dermoscopically, and histologically can appear atypical compared with pigmented lesions on the rest of the body. Thus, it is imperative to use not only a keen eye but also a low threshold for biopsy. PMID:20883921

Venkatesan, Aruna

2010-10-01

135

In squamous cell carcinoma of the vulva, overexpression of p53 is a late event and neither p53 nor mdm2 expression is a useful marker to predict lymph node metastases  

PubMed Central

To offer more tailored treatment to individual patients with squamous cell carcinoma of the vulva, more accurate prediction of lymph node metastases is required. As p53 and mdm2 are genes known to be involved in the development of other tumours, we studied expression of p53 and mdm2 in carcinogenesis of squamous cell carcinoma of the vulva and their clinical relevance. Archival material of 141 T1 and T2 vulvar tumours were used. Of the 141 primary tumours, the corresponding 39 lymph node metastases (LNM) were studied, and in 90 cases the pre-existent epithelia adjacent to the tumour (EAT) and in 14 cases vulvar intraepithelial neoplasia adjacent to the tumour (VIN) was also investigated. Detection of p53 and mdm2 protein was immunohistochemically performed. Scoring categories were: negative (1); weakly positive (2); moderately to markedly positive (3); and markedly positive (4). Overexpression of p53 was seen in 56% of the LNM, 39% of the primary tumours, 21% of the VIN lesions and 0% in the group of EAT. No relation was found between overexpression of p53 in the primary tumour and LNM. Expression of mdm2 was seen in 14% of the primary tumours, of which four cases were marked positive. In the group of LNM no mdm2-positive staining was observed. In the group of EAT, 25% was mdm2-positive, of which six cases were marked positive. In the group of VIN, 36% showed moderate (score 3) mdm2 expression. No relation was found between expression of mdm2 and LNM. In squamous cell carcinoma, overexpression of p53 is a late event in carcinogenesis. Marked expression of mdm2 is rarely seen in vulvar carcinomas, indicating that aberrant p53 cannot induce mdm2 expression. LNM cannot be predicted by detection of these proteins. © 1999 Cancer Research Campaign

Emanuels, A G; Koudstaal, J; Burger, M P M; Hollema, H

1999-01-01

136

[Ocular sparganosis in the Czech Republic--a case report].  

PubMed

The authors report a case of 14-year-old boy presented to the Ophthalmologic Department of University Hospital in Olomouc with the diagnosis af acute anterior uveitis. A living parasite has been detected in the anterior chamber in a slit lamp examination. The vitreous and retina remained uninvolved. The acute iridocyclitis associated with parasitic infection is a very rare cause of anterior uveitis in Central Europe. The patient underwent surgical removal of the parasite via paracentesis. The inflammation resolved under the treatment with atropine and dexamethasone drops within a few days. Histopathological examination revealed the parasite as a young larval stage of tapeworm from family Pseudophyllidea (sparganum). Based on the analysis of development cycles of different types of tapeworms and according the literature data on tapeworms found in the Czech Republic genus Spirometra seemed to be the most plausible cause of the patient's disease. As the most probable source of viable parasites authors suspect swallowed water containing tiny infected crustaceans in the dam near the town Olomouc in Moravia. PMID:16958022

Rehák, M; Kolárová, L; Kohnová, I; Rehák, J; Mohlerová, S; Fric, E; Chrapek, O

2006-08-01

137

Symptomatic Morgagni Hernia Misdiagnosed As Chilaiditi Syndrome  

PubMed Central

Chilaiditi syndrome, symptomatic interposition of bowel beneath the right hemidiaphragm, is uncommon and usually managed without surgery. Morgagni hernia is an uncommon diaphragmatic hernia that generally requires surgery. In this case a patient with a longstanding diagnosis of bowel interposition (Chilaiditi sign) presented with presumed Chilaiditi syndrome. Abdominal computed tomography was performed and revealed no bowel interposition; instead, a Morgagni hernia was found and surgically repaired. Review of the literature did not reveal similar misdiagnosis or recommendations for advanced imaging in patients with Chilaiditi sign or syndrome to confirm the diagnosis or rule out other potential diagnoses.

Vallee, Phyllis A.

2011-01-01

138

Cerebral Vein Thrombosis Misdiagnosed and Mismanaged  

PubMed Central

Cerebral venous thrombosis (CVT) should be considered in the differential diagnosis of all unexplained CNS disorders of sudden onset. Etiological factors are often subclinical forms of several common thrombophilic states occurring together, rather than the typical inherited and rare causes. Diagnosis is missed because of the heterogeneity in clinical presentation and etiological factors. In several patients with the so called idiopathic CVT nutritional deficiencies and lifestyle issues are more important factors in pathogenesis, rather than single rarer causes. High index of suspicion is the key to diagnosis. Clinical skill has to be fine tuned to diagnose the problem and to identify all the etiological factors. Radiology is essential for diagnosis but relying on radiology alone will lead to missing several cases and even erroneous diagnosis. It is inappropriate to proceed prematurely to laboratory investigations, forgetting proper clinical evaluation by studying diet, lifestyle, and environment of the patients. Success in managing lies in identifying all the contributory causes and correcting all of them giving excellent outcome almost always. Clinical observations based on case series and sharing of such information alone are the means to arrive at a consensus in diagnosis and management.

Sasidharan, P. K.

2012-01-01

139

Childhood femoral hernia: a commonly misdiagnosed condition  

Microsoft Academic Search

Femoral hernia is a rare surgical entity in the paediatric age group. The diagnosis is still a challenging issue. The aim of our study was to review our experience with femoral hernias in children during the past 21 years. We reviewed retrospectively the medical records of all patients who underwent femoral hernia repair in our institution between 1980 and 2000. Thirty-eight

D. De Caluwé; B. Chertin; P. Puri

2003-01-01

140

Methemoglobinemia misdiagnosed as ruptured ectopic pregnancy.  

PubMed

A 22-year-old woman with an initial diagnosis of 'ruptured ectopic pregnancy' and 'hemorrhagic shock' was sent to the operation room for surgical treatment. The mucocutaneous color was deeply cyanosed and the pulse oximeter oxygen saturation (SpO2) was only 86% after tracheal intubation (100% O2). 'Chocolate-brown' blood was observed and methemoglobinemia was considered. Then the arterial blood gas (ABG) sample was obtained, an intravenous infusion of methylene blue and vitamin C followed. The patient recovered quickly, and later two other patients with similar symptoms were treated in the same way. The success was due to a correct diagnosis accompanied with prompt treatment and quick recognition of the etiology. PMID:15777313

Yang, J J; Lin, N; Lv, R; Sun, J; Zhao, F; Zhang, J; Xu, J G

2005-04-01

141

Permanent junctional reciprocating tachycardia misdiagnosed as 'cardiomyopathy'.  

PubMed

In a nine-year-old female, cardiac failure was erroneously attributed to idiopathic cardiomyopathy and cardiac transplantation was planned. The actual cause of cardiac failure was permanent junctional reciprocating tachycardia (PJRT), a rare form of supraventricular tachycardia. The diagnostic error was discovered before transplantation was performed and the arrhythmia was treated surgically. This resulted in return of near normal cardiac function. PMID:1872752

McGuire, M A; Lau, K C; Davis, L M; Knight, P; Uther, J B; Ross, D L

1991-04-01

142

SKIN ULCERS MISDIAGNOSED AS PYODERMA GANGRENOSUM  

Microsoft Academic Search

Background Pyoderma gangrenosum is a diagno- sis of exclusion, and the misdiagnosis of pyoderma gangrenosum can result in substantial complications in patients who have other causes of severe cutane- ous ulceration. Methods We reviewed the charts of 240 patients with a diagnosis of pyoderma gangrenosum who were eval- uated at our institution from 1975 through 2000, in- cluding 157 consecutive

R OGER H. W EENIG; M ARK; D. P. D AVIS; P ATRICK; R. D AHL; W. P. D ANIEL

2010-01-01

143

Endogenous endophthalmitis initially misdiagnosed as anteiror uveitis  

Microsoft Academic Search

A diabetic man was found to, have endogeneous endophthalmitis associated with a bilobar prostatic abscess. Initially, anterior\\u000a uveitis had been diagnosed, which delayed definitive diagnosis and therapy. After the correct diagnosis, the patient was successfully\\u000a treated with vitrectomy as well as intravitreal, topical, and systemic antibiotics. Endogenous endophthalmitis should always\\u000a be considered early in the differential diagnosis of anterior uveitis.

Jorge G. Arroyo; Daniel A. Brinton; Marco A. Zarbin

2000-01-01

144

A Woman with Recurrent Pruritus Vulvae  

Microsoft Academic Search

\\u000a Two years later Margaret (Case 11) returns to the surgery. Over the past 18 months she has had at least ten episodes of vulval\\u000a itch. She tells you that she has purchased both topical and oral antifungal preparations from her local pharmacist. Although\\u000a these treatments have given some relief for a few weeks, nothing seems to “fix my problem permanently.”

Alexander McMillan

145

A Woman with Pruritus Vulvae (2)  

Microsoft Academic Search

\\u000a Margaret (Case 11 and 24) returns to the Sexual Health clinic 6 years later with a 4 week history of vulval itch. Although\\u000a she has had no recurrences of candidiasis for 3 years, she thought that candidiasis was the most likely cause of her symptoms\\u000a and she self-medicated with oral fluconazole and topical clotrimazole, obtained over the counter from a

Alexander McMillan

146

Vulval dermatoses  

Microsoft Academic Search

Vulval dermatoses are common and can cause significant symptoms. Any generalized skin disorder may affect the anogenital area, but the most common are eczema and psoriasis. Other dermatoses preferentially affect the vulva (e.g. lichen sclerosus, lichen planus). Itching and soreness are the most common symptoms. Many women are not examined and are misdiagnosed with ‘thrush’. Self-treatment with topical medications may

EK Derrick; Sallie Neill

2005-01-01

147

A Case of Sparganosis mansoni in the Thigh: Serological Validation of Cure Following Surgery  

PubMed Central

Cases of Sparganum mansoni, caused by the plerocercoid larva of the tapeworm S. mansoni, occur throughout the world, particularly in Asian, Middle Eastern, and European countries. However, cases of infection with this parasite are rarely seen in Japan. Here, we present a case of a 61-year-old woman with a solitary subcutaneous nodule in left inner aspect of the thigh, from which a long, slender, whitish worm was surgically removed. The parasite was histopathologically identified as S. mansoni. Serological testing confirmed cure of the infection after surgical removal of the parasite. The authors advocate immunoserological examination in case of S. mansoni.

Chiba, T; Yasukochi, Y; Moroi, Y; Furue, M

2012-01-01

148

A Case of Sparganosis mansoni in the Thigh: Serological Validation of Cure Following Surgery.  

PubMed

Cases of Sparganum mansoni, caused by the plerocercoid larva of the tapeworm S. mansoni, occur throughout the world, particularly in Asian, Middle Eastern, and European countries. However, cases of infection with this parasite are rarely seen in Japan. Here, we present a case of a 61-year-old woman with a solitary subcutaneous nodule in left inner aspect of the thigh, from which a long, slender, whitish worm was surgically removed. The parasite was histopathologically identified as S. mansoni. Serological testing confirmed cure of the infection after surgical removal of the parasite. The authors advocate immunoserological examination in case of S. mansoni. PMID:23109970

Chiba, T; Yasukochi, Y; Moroi, Y; Furue, M

2012-01-01

149

Atypical Guillain-Barr? Syndrome Misdiagnosed as Lumbar Spinal Stenosis  

PubMed Central

Guillain-Barré syndrome (GBS) is an acute inflammatory demyelinating polyneuropathy. In typical cases, the first symptoms of GBS are pain, numbness, paresthesia, weakness in the limbs. Autonomic involvement is common and causes urinary retention and ileus. Much of these symptoms overlap with those of lumbar spinal stenosis. Therefore, correct diagnosis of GBS in a patient with symptomatic lumbar spinal stenosis or in a patient with atypical manifestations of GBS can be difficult, especially early in the course of GBS. Here, we report on a case of atypical GBS in a 74-year-old previously healthy patient with lumbar spinal stenosis and discuss the differential diagnosis of the GBS and lumbar spinal stenosis.

Jung, Dae Young; Lee, Seung Chul

2013-01-01

150

Neuro-ophthalmic systemic lupus erythematosis misdiagnosed as hysterical blindness.  

PubMed

The authors present a case of neuro-ophthalmic systemic lupus erythematosus in which an initial diagnosis of "hysteria" was made. The authors review the ophthalmic symptoms of systemic lupus erythematosus and technical aspects of the ophthalmic examination useful in differentiating organic from functional blindness. PMID:7114319

Stoudemire, A; Stork, M; Simel, D; Houpt, J L

1982-09-01

151

A complication of a dropped appendicolith misdiagnosed as Crohn's disease.  

PubMed

Appendicoliths are formed by calcium salts and faecal debris layered and lodged within the appendix. They are detected on unenhanced x-rays in less than 10% of patients with appendicitis. When an appendicolith is found extraluminally, it is pathognomonic for perforation of the appendix. Moreover, retained appendicoliths act as a nidus for infection and are likely to be the source of a postoperative intraperitoneal abscess. However, this is very rare with only 30 reported cases of intra-abdominal abscess secondary to an appendicolith in the literature over the past 40 years. Retained, or dropped, appendicoliths most commonly present as an area of high attenuation less than 1cm in diameter with an associated abscess close to the caecum or Morrison's pouch on computed tomography (CT). A study published in 2006 showed that although there is initial success with CT-guided drainage of abscesses secondary to faecaliths, all will recur and formal surgical drainage with removal of the appendicolith is required. This case report highlights not only an unusual complication of a retained appendicolith but also the importance of taking a thorough history and interpreting investigations in the context of the patient's past medical history so as to produce a differential diagnosis and prevent treatment of incorrect conditions. PMID:21929906

Sarkar, S; Douglas, L; Egun, A A

2011-09-01

152

Tumors About the Knee Misdiagnosed as Athletic Injuries  

Microsoft Academic Search

Background: Musculoskeletal tumors may originally mimic a traumatic condition, and, on the basis of an erroneous diagnosis of an athletic injury, an invasive diagnostic or therapeutic procedure may be performed. We determined the number of such cases treated at our institution, and we analyzed the initial and final diagnoses as well as the changes in the indicated oncologic surgical technique

D. LUIS MUSCOLO; MIGUEL A. AYERZA; ARTURO MAKINO; MATÍAS COSTA-PAZ; LUIS A. APONTE-TINAO

2003-01-01

153

Underdiagnosis of anaphylaxis in the emergency department: misdiagnosed or miscoded?  

PubMed

OBJECTIVES. To distinguish allergic reactions and anaphylaxis, and to highlight the importance of anaphylaxis. DESIGN. Case series. SETTING. Adult emergency department of the medical faculty of Hacettepe University, Ankara, Turkey. PATIENTS. Adults admitted to the emergency department between 1 May 2005 and 30 April 2010 with allergic diseases considered to be anaphylaxis or anaphylactic reactions. MAIN OUTCOME MEASURES. Patient age, gender, possible cause(s) of allergy, organ involvement, treatment, and physical examination findings. RESULTS. Although recorded physical examination findings of patients were consistent with anaphylaxis, 88 patients were not diagnosed as having this condition. All patients in this study group were evaluated in the emergency department facility and did not consult or were not referred to any other department or specialist. In all, 79 (90%) of them were discharged in the first 12 hours, 5 (6%) after 12 to 24 hours, and 4 (5%) after 24 hours. None of these patients died. CONCLUSION. Emergency physicians should be better able to recognise the clinical features of anaphylaxis, so as to treat the episode promptly and appropriately. Delay in diagnoses could lead to incomplete treatment and even be fatal. PMID:23687212

Hocagil, H; Karakilic, E; Hocagil, C; Senlikci, H; Buyukcam, F

2013-05-20

154

Misdiagnosed food allergy resulting in severe malnutrition in an infant.  

PubMed

As food allergies become increasingly prevalent and testing methods to identify "food allergy" increase in number, the importance of careful diagnosis has become even more critical. Misdiagnosis of food allergy and inappropriate use of unproven testing modalities may lead to a harmful food-elimination diet. This case is an example of an infant who was placed on an overly restrictive elimination diet at the recommendation of her health care providers, resulting in kwashiorkor and acquired acrodermatitis enteropathica. PMID:23733797

Alvares, Michael; Kao, Leon; Mittal, Vineeta; Wuu, Alice; Clark, April; Bird, J Andrew

2013-06-03

155

Misdiagnosing the Problem: Mental Health Profiles of Incarcerated Juveniles  

PubMed Central

Aggression, antisocial and delinquent behavior frequently result in the incarceration of a large number of young people, but these problems pale in comparison to the mental health challenges faced by many of these youth. Recent studies show a high prevalence of mental disorders among adolescents within the justice system. These findings have led researchers, clinicians and policy-makers to re-evaluate the assessment and treatment options that are available for youth within correctional facilities. This article provides a concise review of the most recent research related to mental health disorders among incarcerated juveniles within Canada and the United States. Rates of some of the most common mental health disorders among juveniles, including depression, anxiety, attention deficit hyperactivity and substance use are summarized. Throughout the review, issues related to co-morbidity and gender differences are highlighted. The implications of mental health disorders for juvenile justice policy and practice are discussed.

Odgers, Candice L.; Burnette, Mandi L.; Chauhan, Preeti; Moretti, Marlene M.; Reppucci, N. Dickon

2005-01-01

156

Misdiagnosing the Problem: Mental Health Profiles of Incarcerated Juveniles  

Microsoft Academic Search

Aggression, antisocial and delinquent behavior frequently result in the incarceration of a large number of young people, but these problems pale in comparison to the mental health challenges faced by many of these youth. Recent studies show a high prevalence of mental disorders among adolescents within the justice system. These findings have led researchers, clinicians and policy-makers to re-evaluate the

Candice L. Odgers; Mandi L. Burnette; Preeti Chauhan; Marlene M. Moretti; N. Dickon Reppucci

157

A case of Hashimoto's encephalopathy misdiagnosed as viral encephalitis  

PubMed Central

Patient: Male, 61 Final Diagnosis: Hashimoto’s encephalopathy Symptoms: Neuropsychiatric or neurological manifestations Medication: Steroids and immunoglobulins Clinical Procedure: Immunoglobulin combined with corticosteroid therapy Specialty: Neurology Objective: Mistake in diagnosis Background: Hashimoto’s encephalopathy is a rare autoimmune syndrome characterized by various neuropsychiatric or neurological manifestations and associated with Hashimoto’s thyroiditis, responsive to steroids. Until now, misdiagnosis and delay of treatment of Hashimoto’s encephalopathy are very common because of the diversity of the symptoms. Case Report: This recent case of a 61-year-old man presented with unconsciousness, spasms and a previous misdiagnosis as viral encephalitis. Response to anti-viral and steroid therapy was unsatisfactory, but treatment with immunoglobulin combined with corticosteroid therapy achieved rapid and complete recovery. Conclusions: Any patient presenting with acute or subacute unexplained encephalopathy should be considered Hashimoto’s encephalopathy, even if the thyroid function is normal. Thyroid antibody testing should be performed because this may be the most important clue to diagnosis. As soon as the diagnosis is made, steroid therapy is the first choice. If the steroid therapy does not lead to immediate improvement, IVIG is an effective alternative treatment.

He, Lei; Li, Mei; Long, Xiao-Hong; Li, Xiang-Pen; Peng, Ying

2013-01-01

158

Causes of imbalance and abnormal gait that may be misdiagnosed.  

PubMed

Disorders of gait and balance are common in medicine and often lead to referral for neurologic evaluation. Because the maintenance of balance and normal gait are mediated by complex neurologic pathways as well as musculoskeletal, metabolic, and behavioral considerations, the list of possible contributing causes is very large. Much of the time, the history and neurologic examination reveal the underlying cause or causes. There are instances, however, when there are limited neurologic findings, as well as no structural abnormalities on brain or spine magnetic resonance imaging studies to explain the imbalance or gait difficulty. In this article, selected disorders that may be overlooked in the neurologic examination and imaging studies are reviewed. Possible causes of imbalance include occult drug-induced ataxia, autoimmune ataxia, ataxia associated with tremor, bilateral vestibular hypofunction, and spastic or dystonic gait disorders with normal imaging. PMID:24057830

Shill, Holly A; Fife, Terry D

2013-09-21

159

A case of galactosemia misdiagnosed as cow's milk intolerance.  

PubMed

We report on a female patient affected by galactosemia in whom the diagnosis was obscured by the concomitant presence of manifestations suggesting a cow's milk intolerance. This case exemplifies the problems in reaching a correct diagnosis in patients with metabolic diseases. PMID:22992216

Della Casa, Roberto; Ungaro, Carla; Acampora, Emma; Pignata, Claudio; Vajro, Pietro; Salerno, Mariacarolina; Santamaria, Francesca; Parenti, Giancarlo

2012-09-19

160

A case of galactosemia misdiagnosed as cow's milk intolerance  

PubMed Central

We report on a female patient affected by galactosemia in whom the diagnosis was obscured by the concomitant presence of manifestations suggesting a cow’s milk intolerance. This case exemplifies the problems in reaching a correct diagnosis in patients with metabolic diseases.

2012-01-01

161

How to diagnose (and not misdiagnose) pernicious anaemia.  

PubMed

The diagnosis of pernicious anaemia requires the demonstration that megaloblastic haemopoiesis is present, that vitamin B12 deficiency is present and that gastric intrinsic factor is lacking. The first, generally requires marrow aspiration, the second is satisfied by a low serum B12 level and the third by B12 absorption tests with and without intrinsic factor. The reasons why these three criteria are the minimum criteria for diagnosis are discussed as well as pitfalls in the performance of tests and in interpretation of data. Finally, a low serum vitamin B12 with impaired B12 absorption improved by the addition of intrinsic factor in the absence of blood changes indicates severe atrophic gastritis but not pernicious anaemia. PMID:3332113

Chanarin, I

1987-12-01

162

An Unusual Presentation of Pelvic Leiomyomatosis Misdiagnosed as Disseminated Malignancy  

PubMed Central

Leiomyomatosis peritonealis disseminata (LPD) is an exceedingly rare, usually benign condition that clinically simulates a disseminated malignancy, occurring predominantly in women of childbearing age. We present a case of LPD in a postmenopausal woman who had undergone hysterectomy 8 years back for fibroids along with simultaneous presence of pelvic metastasis from breast carcinoma.

Marwah, Nisha; Duhan, Amrita; Aggarwal, Garima; Sen, Rajeev

2012-01-01

163

Vibrio vulnificus sepsis misdiagnosed as simple deep vein thrombosis.  

PubMed

A 46-year-old man was transferred to the emergency department and suspected of having a deep vein thrombosis. The patient reported swelling and pain in both lower legs for 16 hours. His medical history included liver cirrhosis secondary to alcohol. A detailed history revealed raw fish consumption 1 day before admission. Within 2 hours of arrival, several hemorrhagic bullae developed in the color-changed lesions of both lower legs. The patient's level of consciousness deteriorated to a stupor. He was admitted to the intensive care unit. Despite intensive management with a ventilator, fluid resuscitation, vasopressors, and intravenous antibiotics (doxycycline, vancomycin, and a third-generation cephalosporin), the patient died within 23 hours of the onset of symptoms. At 1 day after the death, a blood culture confirmed the clinical diagnosis of Vibrio vulnificus. Emergency physicians should consider Vibrio vulnificus infections in patients with sepsis and severe skin lesions and should assess (from the medical history) risk factors including consumption of raw seafood and direct exposure to seawater. Prompt diagnosis and treatment for Vibrio vulnificus infections can significantly improve the outcome. PMID:22633714

You, Je Sung; Kim, Seunghwan; Park, Incheol; Kim, Seungho

2012-05-23

164

Macroprolactin; A Frequent Cause of Misdiagnosed Hyperprolactinemia in Clinical Practice  

PubMed Central

Introduction Macroprolactin is a significant cause of misdiagnosis, unnecessary investigation, and inappropriate treatment in patients with hyperprolactinemia. Its frequency has not been clearly established due to technical difficulties in identifying it. Most laboratories and clinicians are unaware of macroprolactin interferences in prolactin assays. Materials and Methods A comprehensive literature search was conducted on the websites of the National Library of Medicine (http://www.ncbl.nlm.nih.gov) and PubMed Central, the US National Library of Medicine's digital archive of life sciences literature (http://www.pubmedcentral.nih.gov/). The data were also looked for in relevant books and journal. Results Macroprolactin is a non-bioactive prolactin isoform usually composed of a prolactin monomer and an IgG molecule having a prolonged clearance rate similar to that of immunoglobulins. This isoform is clinically non-reactive but it interferes with immunological assays used for the detection of prolactin. Conclusion There is a need to understand and explore the recent progress in the diagnosis and pathophysiology of macroprolactinemia for improving patient care.

Vaishya, Richa; Gupta, Rahul; Arora, Sarika

2010-01-01

165

The chronically symptomatic vulva: prevalence in primary health care  

Microsoft Academic Search

OBJECTIVES: To examine within the primary health care setting, the frequency of chronic vulval disorders, their frequency, investigation, management and referral patterns. METHODS: A questionnaire based survey at general practitioners surrounding a district general hospital. RESULTS: A total of 79 (72%) GPs replied to the questionnaire. Thirty-six (45%) GPs saw more than one patient per month with recurrent vulval symptoms

D Nunns; D Mandal

1996-01-01

166

Pseudoepitheliomatous hyperplasia in lichen sclerosus of the vulva.  

PubMed

Small tentacles or separated nests of squamous cells in the dermis are not uncommonly seen in long-standing vulvar lichen sclerosus (LS) associated with epidermal thickening. We recently encountered a case where separated nests of well-differentiated squamous cells in the dermis were difficult to distinguish from squamous cell carcinoma (SCC). Further biopsies showed similar nests originating from every hair follicle. We postulated a diagnosis of multifocal pseudoepitheliomatous hyperplasia (PEH) to explain this phenomenon. Because we could find no reference to PEH in the setting of LS, we reviewed the biopsies of 92 women with extragenital and vulvar LS with and without carcinoma to determine its frequency and histological appearance. The study population, which excluded the index case, comprised 10 women with extra-anogenital LS, 58 with vulvar LS without carcinoma, and 24 with vulvar LS with carcinoma. The presence of PEH, epidermal thickness, predominant dermal collagen change, degree of inflammation, and presence of fibrin and red blood cells were recorded. The presence or absence of lichen simplex chronicus (LSC), squamous cell hyperplasia (SCH), and differentiated vulvar intraepithelial neoplasia (VIN) were recorded. PEH was identified only in vulvar LS, where it was seen in 7/58 (12.1%) women without carcinoma, 1/24 (8.3%) with carcinoma, and 0/10 (0%) with extra-anogenital LS. Two forms of PEH were seen: predominantly epidermal 7/8 (87.5%) and predominantly follicular 1/8 (12.5%). PEH was associated with increased epidermal thickness, less dermal edema, more dermal inflammation, fresh fibrin, and red blood cell extravasation. In all cases, there was associated LSC, but there was no SCH or differentiated VIN. In conclusion, PEH may explain many of the cases of dermal tentacles and separated squamous nests in vulvar LS with LSC. The association with fresh fibrin and red blood cells suggests that PEH might be a reaction to tissue damage. PEH is distinguished from SCC by its lack of atypia, confinement to the abnormal collagen, and limited growth. The pathologist must be careful about making a diagnosis of PEH in LS with epidermal thickening, looking carefully for basal atypia and other features of differentiated VIN in the overlying epidermis or dermal proliferation. We do not know whether PEH occurs in differentiated VIN and, if it does, how it could be distinguished from SCC. PMID:12496699

Lee, Eung Seok; Allen, David; Scurry, James

2003-01-01

167

Vulvar Dermatoses – Irritant and Allergic Contact Dermatitis of the Vulva  

Microsoft Academic Search

Irritant and allergic contact dermatitis are commonly seen in patients complaining about itching, burning and irritation in the vulvar area. Irritation often precedes allergic sensitization. Clinically, irritant and allergic contact dermatitis can be difficult to distinguish. Diagnosis is made by history, clinical investigation and patch testing. Recommended patch test series are the standard series, a medicament series, the patient’s own

A. Bauer; C. Rödiger; C. Greif; M. Kaatz; P. Elsner

2005-01-01

168

Silicone in HIV-1-infected patients: a cause of misdiagnosed granulomatous disease.  

PubMed

Granulomatous diseases are common in HIV-infected patients and are usually related to opportunistic infectious or tumoral conditions. We report three cases of uncommon granulomatous disease in HIV-infected patients who had previously received silicone and for which diagnostic investigations remained negative. PMID:20303811

Males, Sylvia; Joly, Veronique; Adle-Biassette, Homa; Abgrall, Sophie; Lariven, Sylvie; Leboulanger, Nicolas; Yeni, Patrick

2010-03-20

169

Non-nephronal hematuria misdiagnosed as C1q nephropathy: Look before you leap  

PubMed Central

A 19-year-old male presented with persistent macroscopic hematuria for last 3 months. On initial evaluation, he was found to have minimal proteinuria, normal renal function, and normal complement with negative lupus serology. Light microscopy, immunofluorescence and electron microscopy of renal tissue confirmed the presence of C1q nephropathy. Because of poor response to immunosuppressive agent (prednisolone and mycophenolate mofetil), passage of urinary clot once and vexing persistent macroscopic hematuria, alternative diagnosis was considered. Cystourethroscopy showed urethritis of prostatic urethra. Immunosuppressives were stopped and doxycycline started to which hematuria responded dramatically. This case report illustrates that hematuria in this patient was because of undiagnosed urethritis rather than incidental C1q nephropathy.

Mandal, S. N.; Jha, R.; Fatima, R.; Swarnalata, G.

2012-01-01

170

Interstitial granulomatous dermatitis: a misdiagnosed cutaneous form of systemic lupus erythematosus?  

PubMed

Interstitial granulomatous dermatitis (IGD) is a recently described, rare dermatological entity. The clinical features are diverse and the precise aetiology is unknown. We present a rare and atypical case of IGD in a patient with systemic lupus erythematosus (SLE). A 26-year-old woman had been diagnosed with SLE when she was 15 years old. The diagnosis was based on cutaneous, articular, pulmonary, haematological and immunological features. The patient presented with a cutaneous diffuse macular eruption on the limbs, appearing in a cockade (rosette) pattern with a violaceous centre and erythematous surround. The face and trunk were spared. The cutaneous histological features led us to consider a diagnosis of IGD. The lesions disappeared after 15 days of systemic steroid therapy. This case is a new clinical form of IGD with an atypical location and clinical presentation. IGD has usually been associated with drug-related adverse reactions and autoimmune diseases. Reports in the literature of IGD in patients with SLE are rare. PMID:18681887

Blaise, S; Salameire, D; Carpentier, P H

2008-08-02

171

Subcutaneous panniculitis-like T-cell lymphoma misdiagnosed as lupus erythematosus panniculitis  

Microsoft Academic Search

We report a case of subcutaneous panniculitis-like T-cell lymphoma (SPTCL), associated with macrophage activation syndrome,\\u000a mimicking a lupus erythematosus panniculitis (LEP). A 29-year-old woman presented with high fever, general malaise, nausea,\\u000a vomiting, and subcutaneous nodules and ulcerating lesions located on the lower extremities. The histopathology showed an infiltration\\u000a of the panniculus, mostly involving fat, and periadnexial and perivascular structures consistent

Estrella Garcia Gonzalez; Enrico Selvi; Sauro Lorenzini; Roberta Maggio; Susanna Mannucci; Mauro Galeazzi; Roberto Marcolongo

2007-01-01

172

A case of recurrent pancreatitis due to hyperlipidemia misdiagnosed as familial Mediterranean fever  

Microsoft Academic Search

Familial Mediterranean fever (FMF) is prevalent among Arabic, Turkish, Armenian, and Jewish people and it must always be considered in the differential diagnosis of patients from these ethnic groups presenting with recurrent abdominal pain with fever. In cases of fever and recurrent abdominal pain, acute pancreatitis is an important clinical condition, which should be considered in the differential diagnosis. Serum

M. Birlik; T. Demir; M. Zeybel; S. Akar; F. Onen; A. Comlekci; M. Tunca; N. Akkoc

2004-01-01

173

Progressive visceral leishmaniasis misdiagnosed as cirrhosis of the liver: a case report  

PubMed Central

Introduction Visceral leishmaniasis is a potentially life-threatening infectious disease which is caused by parasites of the genus Leishmania and characterized in most cases by the presence of fever as well as signs and symptoms similar to those found in liver cirrhosis. Case presentation In this case report we describe the history of a 50-year-old Caucasian man incorrectly diagnosed as having hepatitis C virus-associated liver cirrhosis, with a massive weight loss of around 100 kg during the previous 2 years. However, suspecting a lymphoproliferative disorder, we were able to make a correct diagnosis of visceral leishmaniasis by bone marrow examination. After a course of therapy with Liposomal Amphotericin-B the patient recovered and now, 20 months post-treatment, he is well and has regained a good part of the lost weight. Conclusions This case taught us that patients with massive splenomegaly, even with a diagnosis of liver cirrhosis, should be investigated for infectious or lymphoproliferative diseases.

2009-01-01

174

Apical pulmonary lesions due to Marfan syndrome misdiagnosed as pulmonary tuberculosis.  

PubMed

A 55-year-male with chest symptoms and apical pulmonary lesions was diagnosed as a case of sputum smear-negative pulmonary tuberculosis at a peripheral health centre in India on the basis of Revised National Tuberculosis Control Programme Guidelines--he was put on antitubercular chemotherapy. He had no radiological or clinical improvement with antitubercular treatment, so the patient was referred to our institute. On evaluation, we found that the patient had multisystem involvement with typical features of Marfan syndrome and a suggestive history in other blood-relatives. Upper lobe fibrosis, bronchiectasis, emphysematous changes, multiple blebs, small pneumothorax, pleural fibrosis and pleural thickening were seen which were due to Marfan syndrome rather than tuberculosis. The present case seems to signify the search for alternative aetiologies in similar clinico-radiological presentations if, after 3 months, cultures for Mycobacterium are still negative (despite sputum induction and/or bronchoscopy with biopsies) and the patient is having no radiological improvement. PMID:20651869

Gupta, Prem P; Gupta, Krishan B; Gulia, Joginder S; Yadav, Rohtas; Kumar, Sanjeev; Agarwal, Dipti

2010-07-16

175

354 Autoimmune Hepatitis Misdiagnosed as Hepatitis C Responding to Interferon/Ribavirine Therapy  

PubMed Central

Background Latent autoimmune hepatitis (AIH) triggered during interferon (IFN) treatment in patients with chronic hepatitis C (CHC) is well known. Here, we report for the first time improvement of AIH using IFN and ribavirin (RBV) in a patient initially incorrectly diagnosed as having CHC. Methods Case report Results 32 years old female was referred because of fluctuating elevations of aminotransferases (AT) (4- to 19-fold normal) known last 6 months. She had positive HCV-RNA by RT-PCR an untypable genotype. Liver biopsy revealed chronic active hepatitis grade 2, stage 2. She also had Hashimoto´s thyroiditis with high titres of antithyroid antibodies. After 12 weeks of treatment with Intron A 3MU TIW and RBV 1000 mg/d, HCV RNA was negative and AT fluctuated between normal and 2-fold normal. One week after completing 48 weeks of treatment, AT showed 11-fold increase, but HCV remained negative. Indirect immunofluorescence became positive for ASMA (3+) and ANA (4+). A repeated liver biopsy showed no improvement. A therapeutic trial with RBV was started and within 11 weeks of this treatment her symptoms markedly improved and AT decreased to 2-fold. Unfortunately, cessation of RBV resulted in immediate reversion of symptoms and elevation of AT to its previous state. After restarting RBV therapy no response was observed within 2 weeks and the treatment was stopped. She was then put on prednisone 30 mg/d and azathioprine 50 mg/d. Within 6 weeks her symptoms resolved and AT and IgG became completely normal. The patient remains in remission with prednisone 5 mg and azathioprine 50 mg/d. A re-evaluation of the primary diagnosis of hepatitis C was warranted because of unusually high AT activity and repeatedly negative anti-HCV using a third generation assay. Conclusions This case may provide support for the hypothesis that RBV may dampen autoimmune reaction induced by IFN alpha and potentiate its anti-inflammatory effects.

Pijak, Michal R.; Csibova, Veronika

2012-01-01

176

Solid-pseudopapillary tumor of the pancreas – a rare and frequently misdiagnosed neoplasm  

Microsoft Academic Search

Introduction: We describe a young woman with an unusual pancreatic tumor. Findings and discussion: Intraoperatively, a smoothly demarcated and encapsulated tumor was exposed. It was large (5 cm4 cm) and of solid consistency,\\u000a with a small stalk attached to the uncinate process. The tumor was partially surrounded by the pancreatic head. The macroscopic\\u000a appearance suggested a benign tumor. Frozen sections

H. Bektas; U. Werner; S. Kaaden; S. Philippou; G. Klöppel; J. Klempnauer

1999-01-01

177

A Common Medical Error: Lung Cancer Misdiagnosed as Sputum Negative Tuberculosis  

Microsoft Academic Search

Objective: To emphasize that delay in diagnosis of lung cancer can be caused by the wrong diagnosis of tuberculosis (TB) in TB endemic countries. This is of major concern as early-diagnosis of lung cancer can increase the chance of tumor resectability and timely chemo-radiotherapy may provide better quality of life. Methods: Proven lung cancer patients, who had received anti-tubercular treatment

Vikas Kumar Singh; Subhash Chandra; Sachin Kumar; Ghanshyam Pangtey; Anant Mohan; Randeep Guleria

2009-01-01

178

A Misdiagnosed Cause of Chronic Pelvic Pain: Abscess with Foreign Body.  

PubMed

Objective.? Chronic pelvic pain may present a diagnostic challenge. Setting.? Academic tertiary care center. Design.? Case report. Case Report.? A 46-year-old woman presented with pain on micturition and a 15-month history of right-sided pelvic pain aggravated by an abdominal massage. Her course and outcome, aided by use of computed tomography (CT) scan, is described, identifying a 6-cm, mass-like lesion in the right lower quadrant enclosing an ambiguous linear calcified lesion, which on laparotomy revealed a fish bone embedded in a section of the terminal ileum and the perivesical area. Conclusion.? Chronic pelvic pain refractory to treatment merits consideration of CT to examine for foreign body. PMID:21995334

Jo, Yun Sung; Lee, Gui Se Ra; Lee, Do Sang; Kim, Sa Jin

2011-10-13

179

Q Fever with Unusual Exposure History: A Classic Presentation of a Commonly Misdiagnosed Disease  

PubMed Central

We describe the case of a man presumptively diagnosed and treated for Rocky Mountain spotted fever following exposure to multiple ticks while riding horses. The laboratory testing of acute and convalescent serum specimens led to laboratory confirmation of acute Q fever as the etiology. This case represents a potential tickborne transmission of Coxiella burnetii and highlights the importance of considering Q fever as a possible diagnosis following tick exposures.

Nett, Randall J.; Book, Earl; Anderson, Alicia D.

2012-01-01

180

Hereditary diffuse leukoencephalopathy with axonal spheroids (HDLS): a misdiagnosed disease entity  

PubMed Central

Hereditary diffuse leukoencephalopathy with spheroids (HDLS) was originally described in a large Swedish pedigree. Since then, 22 reports describing a total of 13 kindred's and 11 sporadic cases have been published. Inheritance is autosomal dominant, albeit the gene is unknown. Here we report on the clinical findings, genealogical data, brain MRI data, and autopsy/biopsy findings of four probands from three independently ascertained novel families from Norway, Germany and US. We identified a 39-year-old female and her twin sister, a 52-year-old male and a 47-year-old male with progressive neurological illness characterized by personality changes, cognitive decline and motor impairments, such as gait problems, bradykinesia, tremor and rigidity. Brain MRI showed white matter abnormalities with frontal prominence. Brain biopsy/autopsies were consistent with HDLS. HDLS is an under-recognized disease and in reporting these cases, we aim to increase the awareness of the disorder. Due to varied and wide phenotypic presentations, which may imitate several neurodegenerative diseases, HDLS can be difficult to diagnose. Definitive diagnosis can be established only by direct brain tissue examination. Familiarity with the clinical presentation and typical neuroimaging findings may be helpful in narrowing the diagnosis.

Sundal, Christina; Lash, Jennifer; Aasly, Jan; ygarden, Sarka ?; Roeber, Sigrun; Kretzschman, Hans; Garbern, James Y.; Tselis, Alex; Rademakers, Rosa; Dickson, Dennis W.; Broderick, Daniel; Wszolek, Zbigniew K.

2011-01-01

181

Spinal cord herniation: a misdiagnosed and treatable cause of thoracic myelopathy  

Microsoft Academic Search

This study is a case report and review of the literature. Spinal cord herniation is a rare, although increasingly recognized,\\u000a cause of spinal cord dysfunction. It is due to an anterior dural defect, through which the spinal cord herniates. The purpose\\u000a of this article is to report the authors’ experience and to provide insight on clinical presentation and radiological signs

Fahed Zairi; Laurent Thines; Philippe Bourgeois; Olivier Dereeper; Richard Assaker

2010-01-01

182

Pulmonary Paracoccidioidomycosis Misdiagnosed as PneumocystisPneumonia in an Immunocompromised Host  

Microsoft Academic Search

Yeast cells of Paracoccidioides brasiliensis can resemble the cysts of Pneumocystis carinii in smears stained with Grocott's modification of the Gomori methanamine silver stain. Furthermore, P. brasiliensis can cross- react in material stained with a widely used P. carinii immunofluorescent stain which uses monoclonal antibodies. The need to differentiateP. brasiliensisandP. cariniiwill become more important as the increasing incidence of immunosuppression

RODGER P. SILLETTI; VALERY GLEZEROV; ANDIRA S. SCHWARTZ

1996-01-01

183

Juvenile Kearns-Sayre syndrome initially misdiagnosed as a psychosomatic disorder  

Microsoft Academic Search

We have investigated a 15 year old girl with progressive external ophthalmoplegia, including bilateral ptosis and retinal rod and cone cell dysfunction with atypical retinal pigmentation, complicated by cerebellar ataxia, partial cardiac conduction block, and diabetes mellitus. In infancy she had a severe crisis of bone marrow depression, and as a child she suffered from hypersensitivity to light, increasing fatigue,

S Nørby; P Lestienne; I Nelson; I M Nielsen; H Schmalbruch; O Sjö; M Warburg

1994-01-01

184

Unusual presentation of two Chinese phenylketonuria sisters who were misdiagnosed for years.  

PubMed

Significant developmental delay was first noticed when both sisters were in their third year of life. However, no biochemical disorders were found through the routine biochemical tests, including liver and kidney function, lipoprotein, urine and blood cell count analysis. Progressively, both sisters exhibited odd behaviour, accompanied by personality changes and altered sleep rhythm and then were diagnosed as attention deficit hyperactivity disorder. In the eighth year, the younger sister began to take risperidone due to a presumed psychiatric disorder. Four months before attending our hospital, both sisters were diagnosed by MRI as having hereditary leukodystrophy. Nerve-nurturing treatment was tried, but without good outcome. They were then referred to our hospital for further consultation. After systematic examinations, it was confirmed that both the sisters were suffering from phenylketonuria. The symptoms were alleviated after dietary restriction of phenylalanine and symptomatic treatment. PMID:24068375

Liu, Xiaomei; Guo, Hui; Dahal, Mahesh; Shi, Bingyin

2013-09-24

185

Enlarged clitoris in wild polar bears ( Ursus maritimus) can be misdiagnosed as pseudohermaphroditism  

Microsoft Academic Search

A 23-year-old female polar bear (Ursus maritimus) killed in an Inuit hunt in East Greenland on July 9, 1999 had a significantly enlarged clitoris resembling, in size, form and colour, those of previously reported ‘pseudohermaphroditic’ polar bears from Svalbard. It has been suggested that an enzyme defect (21-hydroxylase deficiency), androgen producing tumour or high exposure to organochlorines during the foetal

C. Sonne; P. S. Leifsson; R. Dietz; E. W. Born; R. J. Letcher; M. Kirkegaard; D. C. G. Muir; L. W. Andersen; F. F. Riget; L. Hyldstrup

2005-01-01

186

Adult onset asymmetric upper limb tremor misdiagnosed as Parkinson's disease: A clinical and electrophysiological study  

PubMed Central

Summary Approximately 10% of subjects thought clinically to have early Parkinson’s disease (PD) have normal dopaminergic functional imaging (SWEDDs – Scans Without Evidence of Dopaminergic Deficit). SWEDDs are a heterogeneous group. Here we aimed to delineate clinical and electrophysiological characteristics of a distinct subgroup of SWEDDs patients from PD and to clarify the underlying pathophysiology of this subgroup as a form of parkinsonism or dystonia. Therefore we compared clinical details of 25 patients referred with a diagnosis of tremor-dominant PD but with normal DaT SPECT scans (SWEDDs) with 12 tremor-dominant PD patients with abnormal DaT SPECT scans. We performed tremor analysis using accelerometry in the following patients with 1) SWEDDs, 2) PD, 3) primary segmental dystonia with dystonic limb tremor and 4) essential tremor (ET). We used transcranial magnetic stimulation with a facilitatory paired associative stimulation (PAS) paradigm to test if sensorimotor plasticity in SWEDDs resembled the pattern seen in PD, dystonia or ET. Although PD and SWEDDs patients shared several clinical features, the lack of true bradykinesia, occurrence of dystonia, and position- and task-specificity of tremor favoured a diagnosis of SWEDDs, whereas re-emergent tremor, true fatiguing or decrement, good response to dopaminergic drugs as well as presence of nonmotor symptoms made PD more likely. Basic tremor parameters overlapped between SWEDDs, PD, segmental dystonia and ET. However, a combination of re-emergent tremor and highest tremor amplitude in the resting condition was characteristic of PD tremor, while SWEDDs, dystonia and ET subjects had the highest tremor amplitude during action. Both SWEDDs and segmental dystonia patients exhibited an exaggerated pattern of sensorimotor plasticity in response to the PAS paradigm, with spread of excitation to an adjacent hand muscle. In contrast, PD patients showed no response to PAS, and the response of ET patients was no different from controls. Taken together, these results may help differentiate these SWEDDs patients from PD and support our hypothesis that adult-onset dystonia is the underlying diagnosis in this sub-group of patients with SWEDDs.

Schwingenschuh, Petra; Ruge, Diane; Edwards, Mark J; Terranova, Carmen; Katschnig, Petra; Carrillo, Fatima; Silveira-Moriyama, Laura; Schneider, Susanne A; Kagi, Georg; Dickson, John; Lees, Andrew J; Quinn, Niall; Mir, Pablo; Rothwell, John C; Bhatia, Kailash P

2010-01-01

187

Congenital bipartite lunate presenting as a misdiagnosed lunate fracture: a case report  

PubMed Central

Introduction A rare case of congenital bipartite lunate in a child is reported. Carpal variants are very uncommon as independent entities, with only three previous reports of this condition in the English literature. Case presentation An 11-year-old Caucasian boy presented with pain in the left wrist after a fall. Radiographs in the emergency department demonstrated a lunate that was divided into palmar and dorsal parts, causing a misdiagnosis of fractured lunate. Magnetic resonance imaging was then used to differentiate between the two diagnoses. Conclusion Very few cases of bipartite lunate have been reported in the literature, and unless awareness is raised about congenital anomalies such as this variant, confusion may arise.

2011-01-01

188

Mucinous cystadenoma of the appendix misdiagnosed as cystic hydatid disease of the liver: a case report  

PubMed Central

Introduction Primary neoplastic lesions presenting with a mucocele of the appendix are very rare and can be divided into benign variants of mucinous adenomas or cystadenomas, mucinous tumours of uncertain malignant potential or mucinous cystadenocarcinomas. Most of these tumourous mucoceles are asymptomatic and are found incidentally. The major complication of neoplastic mucinous appendiceal tumours is the development of a pseudomyxoma peritonei due to spreading of mucin-producing cells within the abdominal cavity. Case presentation A 44-year-old man presented with a history of non-specific symptoms of right upper abdominal pain. Abdominal ultrasound and computed tomography scan identified a cystic mass consistent with the morphological characteristics of an echinococcal hydatid cyst. After completing systemic albendazole therapy, an explorative laparotomy revealed a cystic tumour of the appendix. Ileocaecal resection was performed and pathology reports confirmed the diagnosis of a mucinous cystadenoma of the appendix. The postoperative course was uneventful. Conclusion Here we present the case of a man with a mucinous cystadenoma of the appendix mimicking cystic hydatid disease. We discuss the importance of re-evaluation and differential diagnostic reflections in cases of appendiceal mucocele.

Krieg, Andreas; Esch, Jan Schulte am; Poll, Ludger W; Braunstein, Stefan; Knoefel, Wolfram T

2008-01-01

189

Gossypiboma: a rare abdominal lesion of women after cesarean section, usually misdiagnosed as a neoplasm.  

PubMed

The case of a 20-year-old pregnant woman with a history of one previous cesarean section (CS) who developed a tumorous mass in the area of the CS scar is presented. The clinical diagnosis of endometriosis or fibromatosis was made but the histologic findings were confusing and the pathological diagnosis of an inflammatory type of liposarcoma was made. The case was referred to our Laboratory for re-evaluation and the diagnosis of gossypiboma was made based on histopathological features, the patient's age, her medical history and the exact location of the lesion. Gossypiboma is a foreign body-related inflammatory pseudotumor caused by retained non-resorbable or even resorbable substances, such as glue, surgical gause or sutures. It is an obscure lesion ignored by doctors of all specialties studying the differential diagnosis of a postoperative mass. PMID:21995171

Mavrigiannaki, P E; Dastamani, C; Vouza, E; Lambropoulou, E; Kairi-Vassilatou, E; Kondi-Pafiti, A

2011-01-01

190

Misdiagnosing the vegetative state after severe brain injury: the influence of medication.  

PubMed

Patients who suffer severe brain damage may be left unaware of self and of the environment and in a permanent vegetative state (PVS). The difficulties in correctly ascertaining unawareness after brain injury have been emphasized by a number of authors. It is well recognized that toxic-metabolic and drug-induced cerebral depression occurs acutely after brain injury. However, less attention has been drawn to the effects of medication months after brain injury and the way in which medication may confound assessment of awareness and, thus, the reliable assessment of long-term prognosis. This paper describes two patients who sustained a severe and well-documented structural brain injury, one hypoxic and one traumatic. Both were unaware when first seen at 3 months post-injury, but both have made useful functional recovery. The paper discusses their progress and how the early prescription of large doses of anti-epileptic drugs, sedatives and anti-spastic agents in these circumstances may result in an initial misdiagnosis of the vegetative state. PMID:14660232

Strens, Lucy H A; Mazibrada, Gordan; Duncan, John S; Greenwood, Richard

2004-02-01

191

Persistent Genital Arousal Disorder Misdiagnosed Because of Islamic Religious Bathing Rituals: A Report of Three Cases  

Microsoft Academic Search

Persistent genital arousal disorder is not well known or adequately understood by physicians. The disorder is characterized by a persistent and highly unwanted state of genital arousal and orgasm-like feelings. Ghusl is an ablution in Islamic culture, which is an obligatory ritual wherein the body is washed thoroughly after exposure to religious contaminants such as sexual intercourse, menstruation, and childbirth.

Ejder Akgun Yildirim; Munevver Hacioglu; Altan Essizoglu; Ilker Kucukparlak

2012-01-01

192

Persistent Genital Arousal Disorder Misdiagnosed Due to Islamic Religious Bathing Rituals: A Report of 3 Cases  

Microsoft Academic Search

Persistent genital arousal disorder (PGAD) is not well known or adequately understood by physicians. PGAD is characterized by a persistent and highly unwanted state of genital arousal and orgasm-like feelings. “Ghusl” is an ablution in Islamic culture, which is an obligatory ritual wherein the body is washed thoroughly after exposure to “religious contaminants,” such as sexual intercourse, menstruation, and childbirth.

Ejder Akgun Yildirim; Munevver Hacioglu; Altan Essizoglu; Ilker Kucukparlak

2012-01-01

193

Cerebellar hemorrhage after spine fixation misdiagnosed as a complication of narcotics use -A case report-  

PubMed Central

Cerebellar hemorrhage occurs mainly due to hypertension. Postoperative cerebellar hemorrhage is known to be associated frequently with frontotemporal craniotomy, but quite rare with spine operation. A 56-year-old female received spinal fixation due to continuous leg tingling sensation for since two years ago. Twenty-one hours after operation, she was disoriented and unresponsive to voice. Performed computed tomography showed both cerebellar hemorrhage. An emergency decompressive craniotomy was carried out to remove the hematoma. On the basis of this case, we reported this complications and reviewed related literature.

Yang, Ki-Hwan; Han, Jeong Uk; Jung, Jong-Kwon; Lee, Doo Ik; Hwang, Sung-Il

2011-01-01

194

Mesothelial Cyst of the Round Ligament Misdiagnosed as Irreducible Inguinal Hernia  

PubMed Central

We report the case of a 36-year-old woman who presented with signs and symptoms of an irreducible inguinal hernia. Surgical exploration revealed a mesothelial cyst of the round ligament of the uterus. Mesothelial cysts of the round ligament are rare lesions, frequently masquerading as inguinal hernias, and should be included in the differential diagnosis of any inguinal mass. Clinical findings are those of a groin mass, discomfort, and bulging. Ultrasound and CT scans often demonstrate an aperistaltic cystic mass. Definitive diagnosis is usually made intraoperatively and confirmed histopathologically.

Manatakis, Dimitrios K.; Stamos, Nikolaos; Agalianos, Christos; Vamvakas, Panagiotis; Kordelas, Athanasios; Davides, Demetrios

2013-01-01

195

Insufficiency fractures of the distal tibia misdiagnosed as cellulitis in three patients with rheumatoid arthritis  

SciTech Connect

We describe 3 patients with rheumatoid arthritis who presented with diffuse pain, swelling, and erythema of the distal aspect of the lower extremity, suggestive of either cellulitis or thrombophlebitis, but were found to have insufficiency fractures of the distal tibia. The value of technetium-99m diphosphonate bone scintigraphy in the early recognition of these fractures and a possible explanation for the associated inflammatory symptoms are discussed.

Straaton, K.V.; Lopez-Mendez, A.; Alarcon, G.S. (Univ. of Alabama, Birmingham (USA))

1991-07-01

196

Tibial torus and toddler's fractures misdiagnosed as transient synovitis: a case series  

Microsoft Academic Search

Introduction  The high incidence of transient synovitis in early childhood makes it the first suspected pathology in a limping child. Trauma,\\u000a which has long been regarded as a causative factor for transient synovitis, may be underestimated in a non-cooperative toddler.\\u000a \\u000a \\u000a After excluding most serious conditions, such as septic arthritis, a speculative diagnosis of transient synovitis can be made,\\u000a and this can

Aksel Seyahi; Serkan Uludag; Burak Alt?nta?; Mehmet Demirhan

2011-01-01

197

Squamous Cell Carcinoma of the Vulva in Brazil: Prognostic Importance of Host and Viral Variables  

Microsoft Academic Search

Background. Certain clinicopathologic features of vulvar squamous cell carcinoma have been correlated with adverse prognosis. However, few large-scale studies have addressed their role in patient survival. This study examined the relationship between multiple variables and prognosis in a large group of vulvar cancers in Brazil.Methods. One hundred eighty-four Brazilian women with vulvar carcinoma were studied and the following variables recorded:

Álvaro P. Pinto; Lisa B. Signorello; Christopher P. Crum; Bernard L. Harlow; Fauzer Abrão; Luisa L. Villa

1999-01-01

198

Graft-versus-host disease of the vulva and\\/or vagina: diagnosis and treatment  

Microsoft Academic Search

We describe a series of women after allogeneic stem cell transplantation with vaginal graft-versus-host disease (GVHD) who were treated with topical cyclosporine, surgery, or both. We reviewed the medical charts of 11 women who presented with vaginal pain, discomfort, and vaginal scarring (inability to perform a Papanicolaou test or have vaginal intercourse because of pain). Vaginal symptoms develop an average

Lisa B Spiryda; Marc R Laufer; Robert J Soiffer; Joseph A Antin

2003-01-01

199

Basal cell carcinoma of the vulva: a report of four cases.  

PubMed

Four cases of vulval basal cell carcinoma were identified in multiparous females aged 46-78 years. Symptoms included discomfort and pruritus ranging from 6 weeks to 4 years in duration. Such symptoms occurred in the context of a pink vulval plaque. The non-specific symptoms, in the context of the particular anatomical site, led to late presentation. Subsequent treatment in all cases involved wide local excision following incisional biopsy. No recurrence has been documented after a minimum follow-up period of 12 months. PMID:18855783

DeAmbrosis, Kathryn; Nicklin, James; Yong-Gee, Simon

2008-11-01

200

Condyloma-like squamous cell carcinoma of the vulva: report of two midline cases  

PubMed Central

Vulvar cancer is uncommon and may be confused with genital condylomata. We report two cases of middle-aged women presenting with exophytic vulvar tumors of the midline for which diagnosis of a vulvar squamous cell carcinoma was confirmed by histopathology. Risk factors, staging, and treatment options are discussed.

Verma, Shyam B; Wollina, Uwe

2012-01-01

201

Concurrent Paget's disease and basal cell carcinoma of the vulva; a case report  

PubMed Central

An 82-year-old Caucasian woman had a long-standing history of recurrent Paget’s disease of the right perianal region that was documented by multiple skin biopsies. Histological examination of a skin biopsy from an erythematous raised right perianal area revealed large rounded cells with ample pale staining cytoplasm scattered throughout the epidermis in multifocal nests and a flattened basal layer. A second lesion showed tongues of basaloid cells with peripheral palisading in continuity with the undersurface of the epidermis at multiple points. The individual tumor nests had cytoplasmic melanization and slit-like stromal separation. The tumor cells in the epidermis showed positive immunoreactivity for carcinoembryonic antigen while the basaloid cells were negative. A diagnosis of combined vulvar Paget’s disease and basal cell carcinoma of an infundibulocystic type was rendered. Concurrent involvement of the same area by Paget’s disease and Basal cell carcinoma (BCC) has been reported only once. Here we report a second case of BCC concurrent with vulvar Paget’s disease.

Abdelbaqi, Maisoun; Shackelford, Rodney E; Quigley, Brian C; Hakam, Ardeshir

2012-01-01

202

Vulvar dermatoses--irritant and allergic contact dermatitis of the vulva.  

PubMed

Irritant and allergic contact dermatitis are commonly seen in patients complaining about itching, burning and irritation in the vulvar area. Irritation often precedes allergic sensitization. Clinically, irritant and allergic contact dermatitis can be difficult to distinguish. Diagnosis is made by history, clinical investigation and patch testing. Recommended patch test series are the standard series, a medicament series, the patient's own topical medicaments, popular remedies and other suspected products. A skin biopsy may be useful to establish the diagnosis of contact dermatitis, but it is usually not helpful for the differential diagnosis between irritant and allergic dermatitis. PMID:15724097

Bauer, A; Rodiger, C; Greif, C; Kaatz, M; Elsner, P

2005-01-01

203

Erythema and burning pain in the vulva: a possible phenotype of erythromelalgia.  

PubMed

We report a case of burning vulvar pain accompanied by erythema responding to an oral combination of a benzodiazepine and a beta blocker. The positive response to two medication classes used in the treatment of erythromelalgia supports the possibility of a localized manifestation of this disorder in the genital region. PMID:21541228

Johnson, Elisabeth; Iyer, Priya; Eanes, Alisa; Zolnoun, Denniz

2011-04-13

204

Erythema and Burning Pain in the Vulva: A Possible Phenotype of Erythromelalgia  

PubMed Central

We report a case of burning vulvar pain accompanied by erythema responding to an oral combination of a benzodiazepine and a beta blocker. The positive response to two medication classes used in the treatment of erythromelalgia supports the possibility of a localized manifestation of this disorder in the genital region.

Johnson, Elisabeth; Iyer, Priya; Eanes, Alisa; Zolnoun, Denniz

2011-01-01

205

Selective Inguinal Lymphadenectomy in the Treatment of Invasive Squamous Cell Carcinoma of the Vulva  

PubMed Central

En bloc radical vulvectomy with bilateral inguinofemoral lymphadenectomy has now been replaced by radical wide excision and selective inguinal lymphadenectomy based on the stage and location of invasive vulvar cancer. Early stage lateral cancers can be effectively treated by radical wide excision and ipsilateral superficial inguinal lymphadenectomy. Lymph node mapping using perilesional injection of radiocolloid and blue dye may identify sentinel lymph nodes which can be removed, thereby avoiding the morbidity of full inguinal lymphadenectomy in selected patients with early stage disease.

DeSimone, Christopher P.; Elder, Jeffrey; van Nagell, John R.

2011-01-01

206

Bartholin's abscess arising within hidradenoma papilliferum of the vulva: a case report  

PubMed Central

Background Hidradenoma papilliferum is an uncommon, benign, cystic, papillary tumor that occurs almost exclusively in the female anogenital region. Bartholin's abscess is also an anogenital cystic lesion caused by obstruction of Bartholin's duct with an overlying infection. Concomitant presentation of Bartholin's abscess and Hidradenoma papilliferum is unique. Case presentation A 43-year-old African American woman presented with a painful cystic mass on the left labia majora. A preoperative diagnosis of Bartholin's abscess was made. During excision and draining, an additional tan-brown dermal nodule was removed which demonstrated histological features of Hidradenoma papilliferum. Conclusion We present what we believe to be the first case of Bartholin's abscess arising in hidradenoma papilliferum and its clinical significance.

Docimo, Salvatore; Shon, Wonwoo; Elkowitz, David E

2008-01-01

207

Imiquimod therapy for extramammary Paget's disease of the vulva: a viable non-surgical alternative.  

PubMed

Extramammary Paget's disease (EMPD) is a rare intraepidermal adenocarcinoma that can affect the vulval skin. Surgical excision is the gold-standard treatment, however, recurrence rates are high and extensive excisions can produce long-lasting cosmetic and functional defects. We describe one of the largest case series to-date (n = 6) on the use of topical 5% imiquimod cream as a novel treatment option and discuss our experiences. With the addition of our six cases to the literature, there are now 29 documented cases of vulval EMPD treated with 5% imiquimod cream. Of these, 50% of primary disease cases and 73% of recurrent primary disease cases have achieved clinical resolution with 5% imiquimod therapy alone. These findings suggest that imiquimod provides a viable alternative to surgical excision for vulval EMPD. However, we acknowledge that this is a simple retrospective analysis and that treatment scheduling and follow-up needs investigation in a trial setting. PMID:23815201

Sanderson, P; Innamaa, A; Palmer, J; Tidy, J

2013-07-01

208

Pseudobowenoid change of the vulva: a histologic variant of untreated condylata acuminatum.  

PubMed

Vulvar condylomata are distinguished from vulvar intraepithelial neoplasia by orderly maturation, a low mitotic index, and the absence of nuclear atypia in the lower epithelial layers. Podophyllin therapy might produce changes in condylomata mimicking vulvar intraepithelial neoplasia but can be distinguished, particularly with a recent history of podophyllin use. This report describes five patients with vulvar condylomata that morphologically resemble both podophyllin effect and vulvar intraepithelial neoplasia. The mean age was 30.5 years. All lesions exhibited superficial keratinocytes in various stages of apoptosis, with a spectrum of nuclear degenerative changes characterized by absence of the nuclear membrane and dispersed nuclear chromatin. The characteristic finding was a perichromatin halo delineated by a rim of dense cytoplasm, beyond which a second zone of uniform clearing was observed, similar to changes noted in vulvar intraepithelial neoplasia. There was an absence, however, of either nuclear atypia in the lower cell layers or apoptosis and mitotic arrest observed in vulvar intraepithelial neoplasia and podophyllin therapy. Two (50%) of four lesions tested positive for human papillomavirus nuclei acids, one by polymerase chain reaction and the other by DNA-DNA in situ hybridization. No common human papillomavirus types were found. Pseudobowenoid change might represents a distinct type of vulvar condyloma, perhaps related to an unusual human papillomavirus. PMID:8729975

Nucci, M R; Genest, D R; Tate, J E; Sparks, C K; Crum, C P

1996-04-01

209

Primary pleural squamous cell carcinoma misdiagnosed as localized mesothelioma: a case report and review of the literature  

PubMed Central

Primary pleural squamous cell carcinoma is very rare, and there is a lack of experience in the diagnosis and treatment of this condition. An asymptomatic 75-year-old man was referred to us after a right pleural nodule was found on computed tomography during a routine health examination. He underwent surgery for his pleural tumor twice over the following 2 years. Histopathological examination eventually led to a diagnosis of primary pleural squamous cell carcinoma.

2013-01-01

210

[Instability and misdiagnosed or neglected dislocations of the upper cervical spine in children. Apropos of 20 cases].  

PubMed

Neglected instabilities or luxations of the upper cervical spine in children are rare if one discards conditions such as chondrodysplasia, Down Syndrome or others, were the spine is known to be at high risk of instability. We have studied twenty cases of neglected luxations and the delay in diagnosis is explained either by the asymptomatic character of some of these lesions, or by the difficulty in diagnosis. At the occipito-atlantal level we have reviewed: an instability in translation which required an occipito-axial fusion; two compensatory counter occipito-atlantal luxation of an atlanto-axial rotatory fixation. The diagnosis was best made with computed tomography scan and the treatment was not much different from the isolated atlanto-axial rotatory luxation. An instability in flexion extension, which was merely followed at regular intervals. At the atlanto-axial level 9 cases of sagittal instabilities in kyphosis and translation with a distance between atlas and axis of more than 5 mm were observed. These instabilities were most often associated with a malformation of the cranio-cervical junction; their treatment was usually surgical by means of an atlanto-axial or occipito-axial arthrodesis depending on the case. 9 other cases of atlanto-axial rotatory luxations were either isolated (7 cases) or associated with a counter occipito-atlantal rotatory subluxation (2 cases). Their diagnosis was made on routine X-rays, but the complete or incomplete aspect of the luxation, as well as its fixed aspect, was best appreciated with dynamic CT scan. Their treatment was always started with collar neck or halo traction in order to obtain, reduction of the dislocation, or at least the disparition of the torticollis and the head straight up on shoulders. The stability of the spine was achieved with a minerva cast jacket, halo cast or spine fusion depending on the case. PMID:1289981

Arlet, V; Rigault, P; Padovani, J P; Finidori, G; Touzet, P; Janklevicz, P

1992-01-01

211

Misdiagnosed Case of Bronchial Carcinoid Presenting with Refractory Dyspnoea and Wheeze: A Rare Case Report and Review of Literature  

PubMed Central

A 59-year-old male smoker presented with persistent wheezing and occasional coughing that had been ongoing for two years and had been unsuccessfully treated with an inhalational ?2 agonist, an anticholinergic and an inhalational steroid in the last year. On clinical examination, a left-sided wheeze was detected. The initial chest X-ray was normal. A computed tomography (CT) scan of thorax demonstrated a mass lesion in the left main bronchus. On subsequent bronchoscopy, an endobronchial polypoid mass was detected in the left main bronchus, completely occluding the bronchial lumen. A biopsy taken from the mass revealed features of bronchial carcinoid. Bronchial carcinoid can present uncommonly with wheezes, resulting in misdiagnosis as bronchial asthma or chronic obstructive pulmonary disease (COPD). If an asthma or COPD patient does not respond to conventional therapy, a CT scan and subsequent bronchoscopy is warranted.

Santra, Avradip; Dutta, Pravati; Pothal, Sudarsan; Manjhi, Rekha

2013-01-01

212

Vulval and perianal inflammatory linear verrucous epidermal naevus.  

PubMed

Inflammatory linear verrucous epidermal naevus (ILVEN) is a rare form of epidermal naevus. It occurs as a linear dermatitic or psoriasiform plaque, with onset usually in the first 5 years of life. Lesions are characteristically intensely itchy. We present a case of ILVEN occurring on the vulva and perianal region of a 6-year-old girl. The lesion was initially thought to be an area of lichenified dermatitis; however, treatment with even super-potent topical corticosteroids did not significantly improve the inflammation. A biopsy was performed and histopathological examination showed characteristic features. ILVEN is frequently refractory to topical treatment and surgical excision of lesions may be an option for relief of symptoms. ILVEN occasionally presents in the inguinogenital region and in this area may, like many vulval naevi, be misdiagnosed as vulvitis, psoriasis, genital warts or sexual abuse. PMID:19397564

Le, Katie; Wong, Li-Chuen; Fischer, Gayle

2009-05-01

213

High levels of p53 expression correlate with DNA aneuploidy in (pre)malignancies of the vulva.  

PubMed

The molecular pathogenesis of human papilloma virus-unrelated vulvar squamous cell carcinoma is not well known. Whether malignant progression of lichen sclerosus and differentiated vulvar intraepithelial neoplasia to vulvar squamous cell carcinoma could be accompanied by altered DNA content has not been studied extensively. DNA content in isolated nuclei of microdissected normal vulvar epithelium (n = 2), lichen sclerosus (n = 9), differentiated vulvar intraepithelial neoplasia (n = 13), and squamous cell carcinoma (n = 17) from 22 patients was measured via DNA image cytometry. For additional analysis, 6 differentiated vulvar intraepithelial neoplasia lesions were selected, bringing the number of patients to 28. p53 expression was determined by immunohistochemistry on consecutive tissue sections. Thirty-eight percent (5/13) of differentiated vulvar intraepithelial neoplasia lesions and 65% (11/17) of squamous cell carcinomas were DNA aneuploid or tetraploid. In lesions that contained differentiated vulvar intraepithelial neoplasia and adjacent squamous cell carcinoma, the ploidy status of differentiated vulvar intraepithelial neoplasia did not exceed that of squamous cell carcinoma. We observed a strong correlation between high p53 expression and DNA aneuploidy. This relation was also present at the level of a single nucleus, measured by sequential image cytometry of p53 immunohistochemistry followed by DNA image cytometry on formalin-fixed tissue sections. Similarly, we found p53-positive nonproliferating cells with increased DNA content in the superficial compartment of 6 additional solitary differentiated vulvar intraepithelial neoplasia lesions that were not associated with squamous cell carcinoma, indicating ascending aneuploid cells from the basal compartment. DNA ploidy measurements suggest that differentiated vulvar intraepithelial neoplasia has a higher malignant potential than lichen sclerosus and thus is a more likely precursor of squamous cell carcinoma. Furthermore, high p53 expression correlates with increased DNA content and aneuploidy; but it requires further research to unveil a possible causal relation. PMID:20656324

van der Avoort, Irene A M; van de Nieuwenhof, Hedwig P; Otte-Höller, Irene; Nirmala, Ella; Bulten, Johan; Massuger, Leon F A G; van der Laak, Jeroen A W M; Slootweg, Piet J; de Hullu, Joanne A; van Kempen, Léon C L T

2010-07-24

214

Premalignant epithelial disorders of the vulva: squamous vulvar intraepithelial neoplasia, vulvar Paget's disease and melanoma in situ.  

PubMed

No standard screening programs exist to detect vulvar carcinoma or its precursor lesions, and therefore gynecologists, dermatologists and other healthcare providers in this field should be aware of the clinical features, behavior and management of the different existing premalignant vulvar lesions, squamous vulvar intraepithelial neoplasia (VIN), vulvar Paget's disease and melanoma in situ. In 2004, a new classification for squamous VIN was introduced by the International Society for the Study of Vulvar Disease, subdividing squamous VIN into the HPV-related usual type, and into differentiated type, which is associated with lichen sclerosus. This review describes the relevant aspects of squamous VIN, vulvar Paget's disease and melanoma in situ, its epidemiological characteristics, diagnosis, management and malignant potential. PMID:20504079

Terlou, Annelinde; Blok, Leen J; Helmerhorst, Theo J M; van Beurden, Marc

2010-06-01

215

Sodium Tetradecyl Sulphate Direct Intralesional Sclerotherapy of Venous Malformations of the Vulva and Vagina: Report of Five Cases  

SciTech Connect

We report five cases of female patients affected by symptomatic focal external genital venous malformations treated with percutaneous direct intralesional injection of sodium tetradecyl sulphate (STS). All patients were referred because of discomfort and pain when sexual intercourse was attempted. Direct sclerotherapy with 3% STS was performed on a day-hospital basis with the patient under local anesthesia. Complete resolution of the symptoms was achieved in all cases. No major adverse effects were reported. Direct intralesional sclerotherapy with STS may be considered a safe and effective method for the treatment of female external genital malformation without the necessity of general anesthesia for pain control.

Krokidis, Miltiadis, E-mail: mkrokidis@hotmail.com [Guy's and St. Thomas' NHS Trust, Department of Radiology (United Kingdom); Venetucci, Pietro [University Hospital 'Federico II', Department of Cardiovascular and Interventional Radiology (Italy); Hatzidakis, Adam [Medical School of Crete (Greece); Iaccarino, Vittorio [University Hospital 'Federico II', Department of Cardiovascular and Interventional Radiology (Italy)

2011-02-15

216

Why are recurrent cervical cancers of the pelvic stump misdiagnosed as interstitial cystitis?: The urologist's point of view based on a case report  

PubMed Central

A 50-year-old female who had undergone laparoscopic total hysterectomy at a local clinic owing to leiomyoma of the uterus was referred to our hospital after having dysuria, urgency, frequency, lower abdominal pain and right flank pain over several months. After routine examinations, cystoscopy, computed tomography and magnetic resonance imaging were performed, and non-ulcerative interstitial cystitis accompanied by postoperative fibrosis secondary to a previous surgery was suggested. Pentosan sulfuric polyester (Elmiron, Alza Pharmaceuticals, Mountain View, CA) reduced her severely debilitating symptoms and improved her quality of life. Both the hydronephrosis and the symptoms were relieved by ureteral stent insertion and percutaneous nephrostomy. However, a few days later, she presented with vaginal bleeding along with her previous symptoms, and punch biopsy of the vaginal stump resulted in a diagnosis of adenocarcinoma. Both ureterocutaneostomy with radical cystectomy and lower anterior resection for rectum invasion were conducted. After the slide review of the original specimen from the local clinic, she was diagnosed with recurrent cervical cancer of the vaginal stump.

Oh, Jin Kyu; Kim, Khae-Hawn

2013-01-01

217

[Severe recurrent intrahepatic cholestasis in systemic AL amyloidosis without obvious liver involvement: unexplained hepatic toxicity or a case of misdiagnosed liver amyloidosis?].  

PubMed

We report the case of a 50-year-old woman who was admitted to the hospital for acute abdominal pain with nephrotic proteinuria, rapidly progressive renal failure, and moderate anemia. Laboratory tests showed mild Bence Jones (?) proteinuria with negative serum immunofixation and a mild increase in ? free light chains. A bone marrow biopsy and a fat tissue aspirate showed multiple myeloma and amyloidosis. Because of the end-stage renal disease, the patient began regular dialysis treatment and was started on bortezomib 1.3 mg/m2 plus dexamethasone 40 mg on days 1, 4, 8 and 11 of 21-day cycles. Ten days later she complained of a new episode of abdominal pain with jaundice. A CT scan and an MRI scan ruled out all secondary causes of cholangitis including cancer. Acute intrahepatic cholestasis due to amyloid deposition was then hypothesized. After 4 well tolerated cycles of bortezomib and dexamethasone, blood tests showed a complete hematological response with full reversal of cholestasis. After three months, a new episode of abdominal pain occurred and this time the patient was operated on and found to have an intestinal volvulus. Because of the jaundice, a transjugular liver biopsy was performed showing no evidence of amyloid deposits. Two months later the patient died of septic shock. Although no autopsy was performed and the ultimate cause of the cholestasis could not be ascertained, amyloidosis remains the major culprit in this unfortunate case. PMID:22388910

Paudice, Nunzia; Farsetti, Silvia; Caroti, Leonardo; Bandini, Sandro; Ciuti, Gabriele; Tempestini, Alessio; Perfetto, Federico; Galli, Simone; Giabbani, Letizia; Caldini, Anna Lucia; Bergesio, Franco

218

Primary parapharyngeal and skull base synovial sarcoma in a 13-year-old boy with neurofibromatosis radiologically misdiagnosed as a benign lesion.  

PubMed

Synovial sarcoma is a rare form of malignant tumour and accounting approximately for 8% of all soft tissue sarcomas. Head and neck synovial sarcomas are uncommon and parapharyngeal space involvement is extremely rare. We report a case of synovial sarcoma in the parapharyngeal space of a 13-year-old boy with a history of neurofibromatosis presented with odynophagia, ptosis and left submandibular mass. The lesion extended from retrostyloid parapharyngeal space to the skull base and foramen jugular superiorly. The first clinical and radiological impressions were carotid jugular related tumours such as schwannoma and paraganglioma. PMID:23737583

Zahir, Shokouh Taghipour; Sharahjin, Naser Sefidrokh; Dadgarnia, Mohammad Hossein

2013-06-03

219

Comparison of the INNO-LiPA and PapType Assays for Detection of Human Papillomavirus in Archival Vulva Dysplasia and/or Neoplasia Tissue Biopsy Specimens ?  

PubMed Central

INNO-LiPA and PapType human papillomavirus (HPV) genotyping assays were compared for detection of HPV genotypes on archival vulvar tissue. The INNO-LiPA assay detected 49 HPV-16 infections, compared with 47 detected by the PapType assay. The INNO-LiPA assay detected amplifiable DNA in 59 (91%) biopsy specimens, compared with 57 (88%) specimens for which amplifiable DNA was detected by the PapType assay. The two genotyping assays were highly comparable.

Tan, Sarah E.; Garland, Suzanne M.; Rumbold, Alice R.; Tabrizi, Sepehr N.

2011-01-01

220

Challenging the concept of microinvasive carcinoma of the vulva: report of a case with regional lymph node recurrence and review of the literature  

Microsoft Academic Search

BACKGROUND: It is widely accepted that vulvar carcinoma with a depth of invasion of less than one millimeter is sufficiently treated by vulvectomy or wide local excision without inguinal lymphadenectomy. CASE PRESENTATION: However, a patient with inguinal lymph node recurrence 21 months after radical vulvectomy for stage IA squamous cell carcinoma was observed. CONCLUSION: According to a review of the

Jutta Sidor; Raihana Diallo-Danebrock; Elke Eltze; Ralph J Lellé

2006-01-01

221

Genital pyoderma gangrenosum: Report of two cases and published work review of Japanese cases.  

PubMed

Pyoderma gangrenosum is an ulcerative skin disorder showing characteristic non-infectious ulcers and affects the lower extremities in approximately 70% of cases. Pyoderma gangrenosum is commonly associated with systemic diseases such as inflammatory bowel disease, rheumatoid arthritis and hematological malignancies. Herein, we report two cases of Japanese patients diagnosed with genital pyoderma gangrenosum. Case 1 was a 74-year-old woman without associated systemic complications, whose skin lesion resembled a squamous cell carcinoma and was limited to the vulva. Case 2 is an 89-year-old man, who suffered from myelodysplastic syndrome and acute myeloid leukemia, and presented with penile and leg ulcers mimicking pressure sores. Both cases responded well to systemic steroids. We review 13 genital pyoderma gangrenosum cases (76.9% male; aged 30-89 years) from 1996 to 2012 in Japan, including 11 previously reported cases and the present study's two cases. Four of the 13 genital pyoderma gangrenosum cases had associated systemic diseases and their skin lesions spread to the extragenital areas. Eight of the remaining nine genitalia-localized pyoderma gangrenosum cases had no associated systemic diseases. In conclusion, genital pyoderma gangrenosum is rare and may be misdiagnosed. It should therefore be considered in cases of refractory genital ulcers. In addition, genitalia-localized pyoderma gangrenosum tends to be without systemic complications. PMID:24033392

Satoh, Masataka; Yamamoto, Toshiyuki

2013-08-21

222

What Is Vulvar Cancer?  

MedlinePLUS

... What is vulvar cancer? The vulva is the outer part of the female genitals. The vulva includes ... vagina (sometimes called the vestibule ), the labia majora (outer lips), the labia minora (inner lips), and the ...

223

"Low-grade leiomyosarcoma" and late-recurring smooth muscle tumors of the uterus: a heterogenous collection of frequently misdiagnosed tumors associated with an overall favorable prognosis relative to conventional uterine leiomyosarcomas.  

PubMed

In most instances, uterine smooth muscle tumors (USMTs) are readily diagnosed as either benign or malignant. Rare patients whose smooth muscle tumors fail to meet leiomyosarcoma (LMS) diagnostic criteria will experience recurrence, and occasional cases of LMS patients experience a protracted clinical disease course. The aim of this study was to investigate whether "low-grade uterine LMS" can be defined as a clinicopathological entity and to learn which histologic features of USMTs correlate with indolent prognosis. We searched institutional databases for cases diagnosed between 1982 and 2008 that had been coded as low-grade LMS and/or cases coded as LMS that were associated with recurrences after 5 years of diagnosis. There were 185 cases with available clinical follow-up data (mean follow-up for survivors was 5.4 y); 57% of patients were dead of disease (DOD), 16% of patients were alive with disease (AWD), and 24% had no evidence of disease (NED). All available slides were reviewed by 2 pathologists (E.V. and R.S.) using Stanford USMT criteria to identify cases of bona fide LMS. Cases were not excluded if they failed to meet these criteria. Nine percent (16 of 185) of tumors had been coded as low-grade LMS. On review of cases with available slides (n=16), only 4 cases (25%) met Stanford USMT criteria for LMS, and 1 additional case was a myxoid LMS. Three cases were reclassified as endometrial stromal sarcomas with smooth muscle differentiation, and 7 cases (44%) failed to meet criteria for sarcoma [ie, they were atypical smooth muscle neoplasms (ASMNs)]. Six of 16 (38%) patients were NED with a mean follow-up of 76 months; 4 of 16 (25%) patients were AWD with a mean follow-up of 102.5 months; 4 of 16 (25%) patients were DOD with a mean follow-up of 79.2 months; and 2 of 16 (12.5%) patients died of unknown causes at 104 and 120 months. Despite being coded as having low-grade LMS in the database, none of the ASMN patients died of disease. Twelve percent of all cases (n=22) were associated with late recurrences. Of the 9 cases with available slides, 5 were bona fide LMSs, and 4 were ASMNs (coded as low-grade LMS in the database and included as part of the low-grade LMS portion of this study). Five of 9 (56%) patients were NED with a mean follow-up of 214 months; 2 (22%) are AWD with a follow-up of 107 and 201 months; and 2 patients were DOD with a follow-up of 108 and 143 months. Bona fide LMS recurrences in this group were earlier (mean, 6.2 y) and frequently fatal (2 of 5), whereas those patients with recurrent ASMN experienced disease progression later (mean, 12 y), and none died of disease. Whether "low-grade" uterine LMSs indeed exist is a matter still open for debate; however, when Stanford criteria are strictly applied, all tumors classified as LMSs should be regarded as intrinsically "high grade." PMID:21921786

Veras, Emanuela; Zivanovic, Oliver; Jacks, Lindsay; Chiappetta, Daniel; Hensley, Martee; Soslow, Robert

2011-11-01

224

Quantitation of proliferation-associated markers Ag-NOR and Ki67 does not contribute to the prediction of lymph node metastases in squamous cell carcinoma of the vulva  

Microsoft Academic Search

A key prognostic parameter for vulvar carcinoma is the presence of lymph node metastases. Determination of proliferation markers has been suggested as a method to predict lymph node metastases in several tumor types. If this were true in vulvar carcinomas, reduced surgical therapy for patients with low-risk vulvar carcinoma could be considered. The authors analyzed whether the proliferation-associated markers silver

Arleen G Emanuels; Matthe P. M Burger; Harry Hollema; Jan Koudstaal

1996-01-01

225

Comportamiento del cáncer de vulva durante 16 años en el Instituto Nacional de Cancerología (Colombia) Behavior of Vulvar Cancer over a 16-year Period at the National Cancer Institute (Colombia)  

Microsoft Academic Search

Objective: To describe patient mortality among patients with vulvar cancer at the National Cancer Institute of Colombia (INC). Materials and Methods: Retrospective cohort study among vulvar cancer patients at the INC from 1990-2006. Survival estimated by Kaplan-Meyer; comparison with logarithmic trial rankings. Results: 303 patients were diagnosed with vulvar cancer, including. One hundred and ninety cases fulfilled inclusion criteria. Average

Mónica Medina; Ricardo Sánchez; Natascha Ortíz; Alexánder Rodríguez; Simón Oróstegui

226

Parasites associated with exotic food  

Microsoft Academic Search

The short description of parasites associated with “exotic food” is by no means inclusive. Many others, such as Toxoplasma gondii, Spirometa spp. (sparganosis), Taenia saginata (cysticercosis), and Echinostoma malayanum, are transmitted via food. Raw sheep liver “sowda” is commonly consumed in Lebanon. Many people developed human toxocariasis after eating this dish (19). The economic loss associated with food-borne parasitic zoonoses

Susan M. Novak

1996-01-01

227

Melanoma vulvar  

Microsoft Academic Search

Vulvar cancer accounts for 5% of all female genital cancers and 1% of all malignancies in women. The most common histological type affecting the vulva is squamous cell carcinoma, accounting for approximately 90%-95% of these lesions. Malignant melanoma is the second most common cancer occurring in the vulva, accounting for about 8%-10% of lesions. This uncommon tumor shows a certain

V. Benito; B. Vega; A. Lubrano; J. A. García-Hernández; O. Falcón

2005-01-01

228

Microinvasive Paget's disease  

Microsoft Academic Search

Background.Microinvasive squamous cell carcinoma of the vulva is defined as stromal invasion ?1 mm and is treated by wide local resection. Whether criteria for microinvasive squamous cell carcinoma can be applied to Paget's disease of the vulva is unknown because of the rarity of that disease.

Thomas Ewing; John Sawicki; Giuseppe Ciaravino; Gregory J. Rumore

2004-01-01

229

CONDILOMA GIGANTE ANOGENITAL EM MENINA DE 12 ANOS VÍTIMA DE ABUSO SEXUAL - RELATO DE CASO GIANT ANOGENITAL CONDYLOMA IN 12-YEAR-OLD-GIRL VICTIM OF SEXUALLY ABUSED - A CASE REPORT  

Microsoft Academic Search

Adolescent, 12 years old, with warts in vulva for seven months, pain and fetid odor after use of podofilina three days ago. Repetitive sexual abuse. Treatment for syphilis four months ago with a single dose of benzatin penicilin. On examination: extensive condyloma in vulva, perineum and peria- nal, with areas of necrosis, purulent discharge and fetid odor. Hypochromic stain on

Araiz CC Pereira; Maria Luiza B Menezes; Angelina F Maia; Romualda CR Barros; Deyse S Carmo

230

Clinical management of vulvodynia  

Microsoft Academic Search

Vulvodynia, also known as burning vulva syndrome, is characterised by sensory abnormalities of the vulva and the surrounding tissue, such as an unpleasant burning and itching sensation, or a painful response to a stimulus that is not usually painful such as sexual intercourse or the touch of a cotton swab. Organic vulvodynia is often treatable once a cause has been

Howard I Glazer; William J Ledger

2002-01-01

231

[Vulval dermatitis: localized condition--serious problem].  

PubMed

An overview of the literature of the dermatitis of the vulva is presented. The etiology, epidemiology, clinical manifestations, diagnosis, pathological diagnosis, treatment, and prevention of contact, allergic-contact, atopic, and seborrheic dermatitis of the vulva are described in details. Lichen simplex chronicus is additionally described as complication of chronic itching dermatitis. PMID:23534270

Kozlovskaia, V V; Tikhonovskaia, I V

232

Morphology and Physiological Changes of Genital Skin and Mucosa  

Microsoft Academic Search

The morphology and physiology of both the vulva and vagina undergo characteristic age-related changes over a lifetime. At birth, these tissues exhibit the effects of residual maternal estrogens. During puberty, the vulva and vagina mature under the influence of adrenal and gonadal steroid hormones. During the reproductive years, the vagina responds to ovarian steroid hormone cycling, and both tissues adapt

Miranda A. Farage; Howard I. Maibach

2011-01-01

233

Zoonotic helminths affecting the human eye  

Microsoft Academic Search

Nowaday, zoonoses are an important cause of human parasitic diseases worldwide and a major threat to the socio-economic development,\\u000a mainly in developing countries. Importantly, zoonotic helminths that affect human eyes (HIE) may cause blindness with severe\\u000a socio-economic consequences to human communities. These infections include nematodes, cestodes and trematodes, which may be\\u000a transmitted by vectors (dirofilariasis, onchocerciasis, thelaziasis), food consumption (sparganosis,

Domenico Otranto; Mark L Eberhard

2011-01-01

234

Rapid resolution of primary vulval adult Langerhans cell histiocytosis with very potent topical corticosteroids.  

PubMed

Langerhans cell histiocytosis is a rare idiopathic disorder with protean clinical presentations. Primary unifocal single-system disease of the vulva is even less common. We report a 62-year-old female patient presenting with an 18-month history of pruritus and burning of the vulva. Clinical examination of the vulva showed a tender nodule of the right labium minus. Histology confirmed Langerhans cell histiocytosis. Systemic involvement was excluded. Within 1 month the use of clobetasol propionate ointment led to resolution of both the patient's symptoms and the clinical appearance of the affected right labium minus. This resolution was maintained 12 months later. PMID:21332684

Foley, Susan; Panting, Katherine; Bell, Hazel; Leonard, Niamh; Franks, Andrea

2011-02-01

235

Chemotherapy of vulvar cancer: a review.  

PubMed

Squamous cell carcinoma of the vulva is a rare disease with good prognosis if diagnosed early. The standard primary therapy is surgery. Neoadjuvant radiation or chemotherapy has been used to achieve resectability of the tumor and to decrease the radicality of the surgery. Chemotherapy with platinum compounds, paclitaxel and targeted therapy (erlotinib) has shown activity. International collaborative trials are needed to identify the best therapeutic strategy for patients with squamous cell cancer of the vulva who are not candidates for primary surgery or concomitant chemoradiation. We review the various treatment options available to patients with advanced or recurrent squamous cell cancer of the vulva. PMID:23519539

Deppe, Gunter; Mert, Ismail; Belotte, Jimmy; Winer, Ira S

2013-03-22

236

Pseudorheumatoid dysplasia. A rare genetic disorder simulating juvenile idiopathic arthritis.  

PubMed

We present the case of a teenage patient with progressive pseudorheumatoid dysplasia, an autosomal recessive disorder that may be initially misdiagnosed as juvenile idiopathic arthritis. PMID:23265789

Duarte-Salazar, Carolina; Santillán-Chapa, Concepción Guadalupe; Martínez-Coria, Elisa; Marin-Arriaga, Norma; Miranda-Duarte, Antonio

2012-12-21

237

Paralyzed Face.  

National Technical Information Service (NTIS)

Discusses various degrees of facial paralysis, often misdiagnosed as Bell's Palsey. Begins with detailed presentation facial anatomy and neurology. Includes question and answer session. Primary audience: physicians.

1994-01-01

238

Lithium: A Treatment for Learning and Behavioral Problems.  

ERIC Educational Resources Information Center

|Lithium carbonate is effective in treating some children with polar (mood) disorders, many of whom, the author suggests may be misdiagnosed as hyperactive, schizophrenic, or behavior disorderd. (CL)|

Heckelman, R. G.

1983-01-01

239

Lichen Sclerosis  

MedlinePLUS

... irritants to your vulva such as harsh soaps, bubble baths, long bike or horseback rides, or other ... loose fitting clothes and avoid irritants such as bubble baths or harsh soaps. Written and reviewed by ...

240

28 CFR 115.6 - Definitions related to sexual abuse.  

Code of Federal Regulations, 2013 CFR

...or the penis and the anus, including penetration, however slight; (2) Contact...the penis, vulva, or anus; (3) Penetration of the anal or genital opening of...or the penis and the anus, including penetration, however slight; (2) Contact...

2013-07-01

241

Trichomoniasis  

MedlinePLUS

... of the body is the lower genital tract (vulva, vagina, or urethra), and in men, the most ... come and go. Men with trichomoniasis may feel itching or irritation inside the penis, burning after urination ...

242

Urination - painful  

MedlinePLUS

... such as yeast or other infections of the vulva and vagina Other causes of painful urination include: ... in the urine ? Are there any rashes or itching in the genital area? What medications are you ...

243

Genetic Analysis of the Vulval Cell Lineages of 'Caenorhabditis elegans'.  

National Technical Information Service (NTIS)

The cell lineages of the nematode Caenorhabditis elegans are essentially invariant among individuals. Researchers have begun an attempt to understand the genetic specification of one particular cell lineage, that of the hermaphrodite vulva. During vulval ...

E. L. Ferguson

1985-01-01

244

Developmental evolution: The unbearable likeness of beings  

Microsoft Academic Search

Comparative studies have revealed a remarkable range of genetic changes in the mechanisms that pattern the nematode vulva. Two new studies identify genetic variation within nematode species that affects cell division and competence in vulval precursors.

Greg Gibson

2001-01-01

245

Female Reproductive System  

MedlinePLUS

... the vulva where the folds of the labia join. Between the labia are openings to the urethra ( ... fluid inside the amniotic sac. The fetus receives oxygen and nourishment from the mother's blood via the ...

246

Vulvodynia  

MedlinePLUS

... For this test, the doctor will use a cotton swab to touch different areas of the vulva ... relief from the pain of vulvodynia: • Wear 100% cotton underwear (no underwear at night). • Avoid tight-fitting ...

247

Cold knife cone biopsy  

MedlinePLUS

... neoplasia of the lower genital tract (cervix, vulva): Etiology, screening, diagnostic techniques, management. In: Katz VL, Lentz GM, Lobo RA, Gershenson DM, eds. Comprehensive Gynecology . 5th ed. Philadelphia, ...

248

The nurse's role in the assessment and treatment of bipolar disorder  

Microsoft Academic Search

The prevalence of bipolar disorder is underestimated, and the condition is often misdiagnosed as depression. Because bipolar disorder does not appear to respond to standard treatments for depression, misdiagnosed patients may suffer increased morbidity and mortality. Nurses have the ability to significantly impact the successful care of these patients by recognizing and assessing bipolar disorder, managing treatment with appropriate mood

Karen Tugrul

2003-01-01

249

Isolated Left Ventricular Noncompaction Cardiomyopathy diagnosed by Transesophageal Echocardiography  

PubMed Central

Isolated noncompaction of the ventricular myocardium has often been misdiagnosed as other cardiomyopathies because it is a relatively recently described cardiomyopathy with literature limited to case reports and case series and little awareness among physicians. We are reporting a case of isolated left ventricular noncompaction cardiomyopathy that was misdiagnosed for over two decades.

Bhat, Tariq; Lafferty, James; Teli, Sumaya; Rjaili, Georges Abou; Olkovsky, Yefim; Costantino, Thomas

2011-01-01

250

Isolated left ventricular noncompaction cardiomyopathy diagnosed by transesophageal echocardiography.  

PubMed

Isolated noncompaction of the ventricular myocardium has often been misdiagnosed as other cardiomyopathies because it is a relatively recently described cardiomyopathy with literature limited to case reports and case series and little awareness among physicians. We are reporting a case of isolated left ventricular noncompaction cardiomyopathy that was misdiagnosed for over two decades. PMID:21487457

Bhat, Tariq; Lafferty, James; Teli, Sumaya; Abou Rjaili, Georges; Olkovsky, Yefim; Costantino, Thomas

2011-02-14

251

Analysis of Parasitic Diseases Diagnosed by Tissue Biopsy Specimens at KyungHee Medical Center (1984-2005) in Seoul, Korea  

PubMed Central

We analyzed parasitic diseases diagnosed by tissue biopsy specimens at KyungHee Medical Center (KMC) from 1984 to 2005. The total number of parasite infection cases was 150 (0.07%) out of the total 211,859 biopsy specimens submitted for histopathological examinations. They consisted of 62 cysticercosis, 23 sparganosis, 16 paragonimiasis, 15 amebiasis, 11 anisakiasis, 11 clonorchiasis, 3 ascariasis, 2 scabies, 2 enterobiasis, 2 trichuriasis, 1 leishmaniasis, 1 taeniasis, and 1 thelaziasis. Out of 62 cysticercosis cases, 55 were detected in subcutaneous tissues or the central nerve system. Eighteen out of 23 sparganosis cases were involved in muscular and subcutaneous tissues. In most anisakiasis cases, the involved organ was the stomach. The lung and the pleura were the most common site of paragonimiasis. The incidence of parasitic diseases during the first 5 years (1984-1988) was the highest of all observed periods. After 1989, similar incidences were shown throughout the period. Whereas cysticercosis was diagnosed in 34 cases during 1984-1988, no case has been diagnosed since 2000. In the case of sparganosis, the chronological incidence was almost uniform throughout the period 1984-2005. Paragonimiasis showed a similar tendency to cysticercosis. In gender and age distribution of parasitic diseases, men showed higher incidence rates than females, and the age groups of the 40s or older indicated higher infection frequencies than other age groups. Therefore, these results are a significant report to appear the tendency of human parasitic disease diagnosed by tissue biopsy in association with parasitosis at KMC in Seoul.

Chu, Jong-Phil; Jiang, Meihua; Lee, Yun-Sik; Kim, Bum-Shik; Kim, Deog-Gon; Park, Yong-Koo

2010-01-01

252

Neuroparasitic Infections: Cestodes, Trematodes, and Protozoans  

PubMed Central

Parasitic infection of the nervous system can produce a variety of symptoms and signs. Because symptoms of infection are often mild or nonspecific, diagnosis can be difficult. Familiarity with basic epidemiological characteristics and distinguishing radiographic findings can increase the likelihood of detection and proper treatment of parasitic infection of the nervous system. This article discusses the clinical presentation, diagnosis, and treatment for some of the more common infections of the nervous system caused by cestodes, trematodes and protozoans: Echinococcus spp., Spirometra spp. (sparganosis), Paragonimus spp., Schistosoma spp., Trypanosoma spp., Naegleria fowlerii, Acanthamoeba histolytica, and Balamuthia mandrillaris.

Walker, M.D.; Zunt, J.R.

2009-01-01

253

Parasitic diseases of the central nervous system.  

PubMed

This article reviews the characteristic imaging appearances of parasitic diseases of the central nervous system, including cysticercosis, toxoplasmosis, cystic echinococcosis, schistosomiasis, amebiasis, malariasis, sparganosis, paragonimiasis, and American and African trypanosomiases. Routine precontrast and postcontrast MR imaging helps in localization, characterization, delineation of extension, and follow-up of the parasitic lesions. Moreover, recently developed tools, such as diffusion, perfusion, and MR spectroscopy, help to differentiate parasitic diseases of the central nervous system from simulating lesions. Combining imaging findings with geographic prevalence, clinical history, and serologic tests is required for diagnosis of parasitic diseases of the central nervous system. PMID:22032501

Abdel Razek, Ahmed Abdel Khalek; Watcharakorn, Arvemas; Castillo, Mauricio

2011-09-03

254

The misdiagnosis of external auditory canal carcinoma.  

PubMed

External auditory canal (EAC) carcinomas are frequently misdiagnosed. The aim of this study was to conduct a review of misdiagnosed cases and analyze the factors involved. This study was a retrospective assessment. Eighteen of 44 EAC carcinoma cases seen at the Eye and ENT Hospital were misdiagnosed. All medical records were retrospectively analyzed for the age, sex, presenting symptoms, type of misdiagnosis, computed tomographic (CT) or magnetic resonance imaging (MRI) findings, stage of the cancer, surgical approach, histopathological examination, adjunctive therapy (postoperative radiotherapy) and outcomes of treatment. Six cases were misdiagnosed as otitis media, five cases were misdiagnosed as otitis externa, and two cases were misdiagnosed as external auditory canal cholesteatomas. Other misdiagnoses were stenosis of the EAC, ear neuralgia, furuncle of the EAC, benign neoplasm of the EAC and pre-auricular fistula. Our analyses suggest that a biopsy should be conducted to obtain a histopathological diagnosis if an EAC carcinoma is suspected, in case otitis media or otitis externa does not respond to routine anti-bacterials. Head and neck MRI should be used to explore the involvement of soft tissues. Patients with bloody ear discharge and otalgia, particularly with temporal bone erosion seen in a CT scan, are highly likely to have a malignant carcinoma of the temporal bone. PMID:22926989

Zhang, Ting; Dai, ChunFu; Wang, ZhengMin

2012-08-25

255

Platynosomum fastosum-induced chronic intrahepatic cholangitis and Spirometra spp. infections in feral cats from Grand Cayman.  

PubMed

The occurrence of platynosomiasis and intestinal sparganosis is described in feral cats from Grand Cayman, Cayman Islands. Spirometra spp. was observed within the intestine of 18.18% (10/55) of cats; 1.18% (1/55) of cats demonstrated gross and histological manifestation of parasitism by Platynosomum fastosum, but 14.5% (8/55) of cats had the characteristic pathological manifestations of P. fastosum-induced intrahepatic cholangitis without the concomitant presence of the intraductal trematode. Combined parasitism (Spirometra spp. and P. fastosum) was observed in 9.09% (5/55) of feral cats. Significant pathological findings were only associated with the hepatic fluke, P. fastosum, and were grossly characterized by moderate hepatomegaly with enlarged and dilated bile ducts. Examples of cestodes with morphological features characteristic of Spirometra spp. were observed within the small intestine without any associated pathological lesion. The histopathological evaluation of liver fragments revealed chronic intrahepatic cholangitis with and without the associated intraductal trematode, and was characterized by marked periductal fibrosis, adenomatous proliferation of bile duct epithelium, dilation of intrahepatic bile ducts and portal accumulations of inflammatory cells. The occurrence of the cestode in feral cats coupled with factors that are unique to Grand Cayman makes this island the ideal location for sporadic cases of human sparganosis. PMID:21729387

Headley, S A; Gillen, M A; Sanches, A W D; Satti, M Z

2011-06-01

256

Epidemiological significance of sero-positive inhabitants against sparganum in Kangwon-do, Korea.  

PubMed

Sparganum is a plerocercoid of pseudophyllidean tapeworms, Diphyllobothrium or Spirometra spp. Human sparganosis is endemic mainly in East and Southeast Asian countries where the custom of eating raw snake or frog meat, or poulticing with snake's skin exists. From January 1995 to November 1999, an epidemiological survey was undertaken to evaluate the serum levels of anti-sparganum specific IgG antibodies in Whachon-gun residents, Korea. An enzyme- linked immunosorbent assay (ELISA) and immunoblot analysis of the sera from 316 subjects were used. In addition, a stool examination from 416 inhabitants and questionnaires regarding the consumption of raw meat were given. Out of 416 inhabitants examined coprologically, one was infected with Clonorchis sinensis and two were infected with Metagonimus spp. The sera from 36 inhabitants (11.4 %) showed a positive reaction to the sparganum antigen. Out of these 36 inhabitants, the sera from 25 people were examined 7, 19, and 50 months later. The sera were found to still show positive reactions without any remarkable changes of anti-sparganum specific antibody titers except for one. An analysis of the questionnaires suggested that a history of eating of raw snakes or frogs was important risk factor for clinical or covert sparganosis (odd ratio=15.6 and 3.1, respectively). PMID:11519077

Park, H Y; Lee, S U; Kim, S H; Lee, P C; Huh, S; Yang, Y S; Kong, Y

2001-08-01

257

Acute intermittent porphyria in Nigerians; a rare disease or a low suspicion index?  

PubMed

The rarity of acute intermittent porphyria (AIP) in Negroes has been emphasized by various authors. But the increasing number of cases reported from the University College Hospital, Ibadan, shows that this may be an overgeneralization. Most of these reported cases have initially been misdiagnosed and only found accidentally to be cases of AIP. Considering the frequency of misdiagnoses in most reported cases, it is worthwhile to alert doctors working among Negro populations to be on the look out for this disease. A simple Watson-Schwartz test for porphobilinogens will save many patients from the unnecessary hazards of treatment they are exposed to when misdiagnosed. PMID:1816669

Lekwuwa, G U; Ogunniyi, A; Orubo, C

1991-07-01

258

Staged reconstruction of the labia minora and reduction clitoroplasty for female pseudohermaphroditism.  

PubMed

Five young pseudohermaphrodite girls with clitoromegaly genital abnormalities are presented. Considering the deficiency and hypogenesis of the local tissue in these young patients, the treatment was performed as a staged operation. First, the cavernosa was mostly removed, and a clitoroplasty was performed to form a clitoris with part of the glans. At 2 weeks after the surgery, the labia minora reconstruction was performed to restore female vulvae using a foreskin flap. The results showed that the transferred foreskin flaps survived well without complications. The vulvae appearance was very good and very much resembled normal female external genitals, both aesthetically and functionally. The authors' experiences have shown that the staged surgical technique could maximize tissue survival to achieve well-formed and aesthetically accurate vulvae. PMID:20414773

Liu, Liqiang; Fan, Jincai; Gan, Cheng; Tian, Jia

2010-04-23

259

[Genetic and environmental variations in an intercellular signaling network].  

PubMed

Interindividual variation, be it of environmental or genetic origin, is crucial for biological evolution as well as in the medical context. This variation is not always directly visible, yet may be revealed under some environmental or genetic condition. In this essay is presented the example of the developmental model system underlying vulva formation in the nematode Caenorhabditis elegans, where an intercellular signaling network (EGF-Ras-MAP kinase, Notch and Wnt pathways) is involved in spatial patterning of the fates of the vulva precursor cells. Variation may be studied at two levels: (1) rare deviations in the system's output, i.e. the spatial pattern of vulva precursor cell fates ; (2) so-called < cryptic > variation in the underlying intercellular signaling network, without change in the system's output. Like every biological system, this network displays genetic and -environmental epistasis. PMID:19765384

Félix, Marie-Anne

260

Paget's disease in an Asian woman.  

PubMed

Extramammary Paget's disease is a rare disease, which mainly occurs in postmenopausal women. The case of Paget's disease of vulva, in a 40 year old Asian woman, who presented with a history of intense itching in vulva for 1 year is being reported. After being medically treated, she was diagnosed on Vulval biopsy. Local excision of the vulval lesion was performed, and histopathology revealed Paget's disease, extending close to the surgical margins. Therefore, a re-excision was performed and patient remained disease free at six months follow up. PMID:21465983

Zia, Asif; Zareen, Nabila

2011-04-01

261

Psoriatic Arthritis  

MedlinePLUS

... arthritis that have similar signs and symptoms, including gout, osteoarthritis and rheumatoid arthritis. In patients with psoriatic ... maintain mobility. Psoriatic arthritis is sometimes misdiagnosed as gout, rheumatoid arthritis or osteoarthritis. The rheumatologist's role in ...

262

Pseudogout  

MedlinePLUS

... that can cause attacks of arthritis . Like with gout, crystals form in the joints. But in pseudogout, ... similar, pseudogout can be misdiagnosed as: Gouty arthritis (gout) Osteoarthritis Rheumatoid arthritis

263

Comparison of Efficacy: Cervarix (AS04 adjuvanted) and ...  

Center for Biologics Evaluation and Research (CBER)

Text Version... Systemic Lupus. ... MS (n=2); Rheumatoid Arthritis; Uveitis (n=1); SLE (n=1 ... insomnia is common; Narcoleptics can be misdiagnosed as insomniacs. ... More results from www.fda.gov/downloads/advisorycommittees/committeesmeetingmaterials

264

Cutaneous leishmaniasis with unusual clinical and histological presentation: report of four cases.  

PubMed

Old world cutaneous leishmaniasis (OWCL) usually causes a single, self-healing and uncomplicated lesion mainly on the exposed area of body. This report presents four cases of OWCL from Iran that misdiagnosed with sarcoidosis, lymphoma, and acne agminata. Two out of four patients showed a history of purplish red plaques for at least 5 years who misdiagnosed as sarcoidosis because of histological and clinical characteristics. The other one presented with flesh-colored nodules disseminated all over his skin that was misdiagnosed as lymphoma for ten years. The last patient was misdiagnosed as acne agminata due to tuberculoid reactions in examination of the lesion biopsy. All the patients responded to the treatment with meglumine antimonate. PMID:23690110

Moravvej, Hamideh; Barzegar, Mohammadreza; Nasiri, Soheila; Abolhasani, Ehsan; Mohebali, Mehdi

2013-05-07

265

78 FR 26780 - Agency Forms Undergoing Paperwork Reduction Act Review  

Federal Register 2010, 2011, 2012, 2013

...diagnosed with the disease) associated with the disease; and (4) better examine the connection between ALS and other motor neuron disorders that can be confused with ALS, misdiagnosed as ALS, and in some cases progress to ALS. The registry will...

2013-05-08

266

75 FR 28621 - Proposed Data Collections Submitted for Public Comment and Recommendations  

Federal Register 2010, 2011, 2012, 2013

...gender, and family history) associated with the disease; and (4) better examine the connection between ALS and other motor neuron disorders that can be confused with ALS, misdiagnosed as ALS, and in some cases progress to ALS. The registry will...

2010-05-21

267

75 FR 4568 - Agency Forms Undergoing Paperwork Reduction Act Review  

Federal Register 2010, 2011, 2012, 2013

...diagnosed with the disease) associated with the disease; and (4) better examine the connection between ALS and other motor neuron disorders that can be confused with ALS, misdiagnosed as ALS, and in some cases progress to ALS. The registry will...

2010-01-28

268

78 FR 9922 - Proposed Data Collections Submitted for Public Comment and Recommendations  

Federal Register 2010, 2011, 2012, 2013

...gender, and family history) associated with the disease; and (4) better examine the connection between ALS and other motor neuron disorders that can be confused with ALS, misdiagnosed as ALS, and in some cases progress to ALS. The registry will...

2013-02-12

269

75 FR 69086 - Agency Forms Undergoing Paperwork Reduction Act Review  

Federal Register 2010, 2011, 2012, 2013

...family history of individuals diagnosed with the disease); and (4) better examine the connection between ALS and other motor neuron disorders that can be confused with ALS, misdiagnosed as ALS, and in some cases progress to ALS. The registry will...

2010-11-10

270

Safely Managing Chronic Pain | NIH MedlinePlus the Magazine  

MedlinePLUS

... and memory loss because of the injury. Melanie Griffith —A skiing accident was followed by three knee ... support of husband Antonio Banderas and her family, Griffith has improved. Montel Williams —A decade of misdiagnoses ...

271

Transient monocular visual loss due to uveitis-glaucoma-hyphaema (UGH) syndrome  

PubMed Central

Uveitis-glaucoma-hyphaema (UGH) syndrome is an unusual cause of transient monocular visual loss which may follow cataract extraction and intraocular lens implantation. If misdiagnosed as amaurosis fugax, patients may undergo unnecessary investigations and inappropriate treatment with aspirin.??

Cates, C.; Newman, D.

1998-01-01

272

Satoyoshi syndrome: a cause of alopecia universalis in association with neurologic and bony abnormalities.  

PubMed

Satoyoshi syndrome is a rare multisystemic disorder characterized by alopecia, diarrhea, muscle spasms, osseous abnormalities, and endocrinopathies. We report a case of Satoyoshi syndrome misdiagnosed as vitamin D-dependent rickets for several years. PMID:22612551

Merino de Paz, Nayra; Rodriguez-Martin, Marina; Contreras Ferrer, Patricia; Eliche, Maria Pestana; Noda Cabrera, Antonio

2012-05-21

273

Quit Obsessing!  

ERIC Educational Resources Information Center

Asserts the obsessive-compulsive disorder is often misdiagnosed in children and adolescents; describes characteristics of obsessive-compulsive disorder; differentiates between normal and abnormal obsessions; suggests ways teachers can help students diagnosed with the disorder. (PKP)

Schlozman, Steven C.

2002-01-01

274

The high-riding superior aortic recess of the pericardium: MRI visualization in a child  

Microsoft Academic Search

We report a 4-year-old child with a high-riding superior aortic recess of the pericardium, initially misdiagnosed as a possible vascular malformation. The anatomy of the pericardial recesses is reviewed.

Mervyn Cohen; Tiffanie Johnson; Mark Hoyer

2005-01-01

275

CADASIL  

MedlinePLUS

... arteries. CADASIL is characterized by migraine headaches and multiple strokes progressing to dementia. Other symptoms include cognitive ... available before 2000, many cases were misdiagnosed as multiple sclerosis, Alzheimer's disease, or other neurodegenerative diseases. Is ...

276

Rare causes of persistent wheeze that mimic poorly controlled asthma.  

PubMed

Upper airway obstruction can present with stridor or expiratory or inspiratory wheeze and is commonly misdiagnosed as asthma. As asthma is common, such cases can remain hidden among patients with lower airway obstruction who attend primary care or respiratory clinics. We describe four causes of upper airway obstruction (paradoxical vocal cord movement, subglottic stenosis, retrosternal goitre and double aortic arch) which were misdiagnosed as 'poorly controlled asthma'. PMID:24072840

Mokoka, Matshediso Constantia; Ullah, Khalil; Curran, David R; O'Connor, Terence M

2013-09-26

277

papillomavirus DNA in invasive vulvar carcinoma  

Microsoft Academic Search

Received 15 July 2003 Abstract Objective. The present study investigates the influence of lymph node pathological features and HPV DNA status on the prognosis of vulvar invasive tumors. Methods. This study includes 184 consecutive cases of primary invasive squamous cell carcinoma of the vulva treated by radical surgery from 1975 to 1992, in Sao Paulo, Brazil. Clinical follow-up data was

Alvaro P. Pinto; Nicolas F. Schlecht; Javier Pintos; Jane Kaiano; Eduardo L. Franco; Christopher P. Crum; Luisa L. Villa

278

Tecniche chirurgiche aTTuali nel carcinoma vulvare  

Microsoft Academic Search

The aim of this review is to give an overview of the surgical management of Squamous Cell Carcinoma (SCC) of the vulva. Today the majority of patients with vulvar SCC can be safely treated by radical wide local excision or partial vulvectomy and bilateral inguinofemoral lymphadenec - tomy with triple incision technique avoiding the more aggressive classic radical vulvectomy with

Leonardo Micheletti; Federica Barberis

279

Prediction of lymph node metastases in vulvar cancer: a review  

Microsoft Academic Search

The aim of this study was to review the literature on currently available non- and minimally-invasive diagnostic methods and analysis of primary tumor characteristics for prediction of inguinofemoral lymph node metastases in patients with primary squamous cell carcinoma of the vulva. We used the English language literature in PubMed and reference lists from selected articles. Search terms included vulvar carcinoma,

M. H. M. OONK; H. Hollema; J. A. de Hullu

2006-01-01

280

Vulvar Squamous Cell Carcinoma in Young Women: A Clinicopathologic Study of 21 Cases  

Microsoft Academic Search

Objectives. Invasive squamous cell carcinoma (ISCC) of the vulva occurs most often in older women and the clinical, pathological, and immunohistochemical features of vulvar ISCC in young women are poorly characterized. The aim of this study was to examine clinical and pathological features of ISCC presenting in women younger than 40 years of age.Methods. Patients younger than 40 years of

A. Al-Ghamdi; D. Freedman; D. Miller; C. Poh; M. Rosin; L. Zhang; C. B. Gilks

2002-01-01

281

Verrucous Carcinoma of the Renal Pelvis with a Focus of Conventional Squamous Cell Carcinoma  

Microsoft Academic Search

Verrucous carcinoma (VC) is a rare variant of squamous cell carcinoma (SCC) with an extremely well-differentiated microscopic appearance. It is able to show extensive local invasion, but practically never metastasizes. VCs mostly occur in the oral cavity, larynx, nasal cavity, esophagus, vulva, vagina, anorectal region, penis and skin. VCs sometimes coexist with conventional SCCs, and in these instances they are

Cavit Can; Turgut Dönmez

2012-01-01

282

A polycystic kidney-disease gene homologue required for male mating behaviour in C. elegans  

Microsoft Academic Search

The stereotyped mating behaviour of the Caenorhabditis elegans male is made up of several substeps: response, backing, turning, vulva location, spicule insertion and sperm transfer. The complexity of this behaviour is reflected in the sexually dimorphic anatomy and nervous system. Behavioural functions have been assigned to most of the male-specific sensory neurons by means of cell ablations; for example, the

Maureen M. Barr; Paul W. Sternberg

1999-01-01

283

Extensive pigmented vulvar basal-cell carcinoma presenting as pruritus in an elderly woman.  

PubMed

Basal cell carcinoma (BCC), the most common human cancer, is seldom seen in the genital area. We present a case of an extensive pigmented BCC that developed on the mucosal surface of the vulva of an elderly woman and briefly review the relevant literature on vulvar BCC. PMID:21272499

Kanitakis, Jean; Arbona-Vidal, Elise; Faure, Michel

2011-01-15

284

Melanoma genital  

Microsoft Academic Search

Genital melanoma is a rare tumor that should always be considered in an old patient with a pigmented lesion on the vulva or even in a patient without apparent injury with a persistent itching and rebellious to standard treatments. The diagnosis is usually delayed (biopsy directed to it). The approach should be multidisciplinary (gynecology-oncology, plastic surgery).

M. Sandino; M. J. Navarrete; J. León; S. Zambrano; T. Lozano

285

Vulvar lichen sclerosus: clinical aspects and guidelines to management  

Microsoft Academic Search

Lichen sclerosus is the second most frequently en- countered non-neoplastic disorder of the vulva. For this rea- son, gynecologists, dermatologists and primary care physicians should have a good understanding of the disease and its treat- ment. Most patients present with significant pruritus and, on examination, will be found to have white patches or plaques extending from the vestibule to the

PETER J. LYNCH; LEONARDO MICHELETTI; FABRIZIO BOGLIATTO

286

Vulvar Discomfort in Hospitalized Dermatological Patients – Preliminary Results  

Microsoft Academic Search

Summary Background: The frequency and importance of pruritus vulvae and vulvodynia are frequently underestimated. We conducted a survey to examine the prevalence and characteristics of these complaints. Methods: Using a questionnaire which we developed, patients hospitalized at the University Dermatology Clinic Halle were questioned about any vulvar complaints and their characteristics. Results: 108 questionnaires were evaluated. Of the respondents, 27

M. Fischer; B. Kreft; S. Born; K.-M. Taube

2001-01-01

287

Chapter 1: HPV in the etiology of human cancer  

Microsoft Academic Search

The causal role of human papillomavirus (HPV) in all cancers of the uterine cervix has been firmly established biologically and epidemiologically. Most cancers of the vagina and anus are likewise caused by HPV, as are a fraction of cancers of the vulva, penis, and oropharynx. HPV-16 and -18 account for about 70% of cancers of the cervix, vagina, and anus

Nubia Muñoz; Xavier Castellsagué; Amy Berrington de González; Lutz Gissmann

2006-01-01

288

Gynaecological cancer  

PubMed Central

Gynaecological cancer encompasses a number of tumours with different epidemiology, pathology and treatment strategies. This article reviews the principal clinical advances and areas of development in cancer of the ovary, cervix, endometrium and vulva.???Keywords: ovarian cancer; cervical cancer; endometrial cancer; vulval cancer

Kitchener, H

1999-01-01

289

Vulvar Merkel Cell Tumor with Glandular and Squamous Differentiation  

Microsoft Academic Search

A case of a Merkel cell tumor of the vulva is presented. In addition to the typical microscopic, immunohistochemical, and ultrastructural features of Merkel cell tumor, there were areas of squamous and glandular differentiation. This is the ninth reported case of a vulvar Merkel cell tumor, and the first where squamous and glandular differentiation were seen. The findings support an

James Scurry; Alison Brand; Robert Planner; John Dowling; Jurgen Rode

1996-01-01

290

Successful Treatment with Lymphaticovenular Anastomosis for Secondary Skin Lesions of Chronic Lymphedema  

Microsoft Academic Search

The treatment of severe lymphedema is a difficult challenge. We performed lymphaticovenular anastomosis on two patients with secondary skin lesions of chronic lymphedema; one patient exhibited acquired lymphangioma circumscriptum of the vulva and the other presented elephantiasis nostras verrucosa of the lower leg. Both patients obtained a remarkable improvement in skin lesions and also in the reduction of lymphedema of

Sei-ichiro Motegi; Atsushi Tamura; Etsuko Okada; Yayoi Nagai; Osamu Ishikawa

2007-01-01

291

Treatment for upper-limb and lower-limb lymphedema by professionals specializing in lymphedema care  

Microsoft Academic Search

Up to 60% of patients with cancer of the vulva, and between 20 and 30% of patients with breast or abdominal cancers may develop lymphedema following treatment. The aims of this study were to assess health profes- sionals' knowledge about treatment, diagnostic procedures, advice and confidence in treatment of patients with either upper-limb (ULL) or lower-limb lymphoedema (LLL), and whether

D. LANGBECKER; S. C. HAYES; B. NEWMAN; M. JANDA

2008-01-01

292

Large Vulvar Lipoma in an Adolescent: A Case Report  

PubMed Central

Lipomas are the most common benign tumors of soft tissues. However, conventional lipomas have been reported only rarely as presenting in the vulva. We present a case of vulvar lipoma in a 17-yr-old woman, possibly caused by chronic intermittent irritation.

Chung, Seung Moon

2008-01-01

293

Morphological and molecular characterization of Pratylenchus lentis n. sp. (Nematoda: Pratylenchidae) from Sicily  

Technology Transfer Automated Retrieval System (TEKTRAN)

Pratylenchus lentis n. sp. parasitizing roots of lentil in Sicily, Italy, is described and illustrated. The new species is characterized by a high lip region with three annuli, stylet mean length of 16 micrometers with anteriorly flattened knobs, cylindrical body with a relatively anterior vulva, l...

294

Penile lichen sclerosus et atrophicus treated with clobetasol dipropionate 0.05% cream: A retrospective clinical and histopathologic study  

Microsoft Academic Search

Background: Treatment with clobetasol propionate 0.05% cream is effective against lichen sclerosus et atrophicus (LSA) of the vulva. Objective: The purpose of this study was to retrospectively evaluate whether clinical and histologic responses to topical clobetasol can be accomplished in penile LSA. Methods: A self-assessment questionnaire was obtained from 22 men with LSA, and a clinical examination was performed in

Kristina Dahlman-Ghozlan; Mari-Anne Hedblad; Geo von Krogh

1999-01-01

295

Female pseudo-hermaphroditism with cloacal malformation and related anomalies in a dog  

PubMed Central

A 7-month-old intact female German shepherd dog was presented with recurrent urinary tract infections and incontinence, ambiguous external genitalia (enlarged vulva containing a penis), and an anovestibular fistula. Anatomical structures, histopathology, and karyotyping supported a diagnosis of female pseudo-hermaphrodite, hypothesized to be a result of in utero androgenization with consequential cloacal malformation.

Sacks, Margot K.; Beraud, Romain

2012-01-01

296

Rapid Quantitative HPTLC Analysis, on One Plate, of Emodin, Resveratrol, and Polydatin in the Chinese Herb Polygonum cuspidatum  

Microsoft Academic Search

The rhizome of Polygonum cuspidatum is an important Chinese medicine used against infectious hepatitis, leucorrhagia, pruritus vulvae of the dampness-heat type, burns, snake bite, carbunculosis, amenorrhea, dysmenorrhea, trauma with blood stasis, and rheumatism, etc. Emodin, resveratrol, and polydatin are main active components of the rhizome. We report a simple densitometric HPTLC method for quantification of these compounds. The method was

Rui-zhi Zhao; Shaojun Liu; Li-lin Zhou

2005-01-01

297

Other Gynecologic Cancers: endometrial, ovarian, vulvar and vaginal cancers  

Microsoft Academic Search

HEALTH ISSUE: In Canada, cancers of the endometrium, ovaries, vulva, vagina, placenta and adnexa account for 11% of all malignant neoplasms in women and 81% of all genital cancers. Although the incidence and mortality from vulvar and vaginal cancers are very low, endometrium and ovarian cancer are important public health problems. KEY FINDINGS: In Canada, there has been no appreciable

Eliane Duarte-Franco; Eduardo L Franco

2004-01-01

298

A Nonhuman Primate Model for the Study of the Cervical Oncogenic Potential of Herpes Simplex Virus Type 21  

Microsoft Academic Search

Summary A primary genital infection with herpes simplex virus type 2 can be established in Cebus monkeys with the develop ment of genital lesions in approximately one-half of the infected animals. The lesions occur on the vulva and on the cervix and occasionally are observed at other sites. As in humans, spontaneous genital recurrences can occur in infected monkeys. Venerai

William T. London; Andre J. Nahmias; Zuher M. IMaib; David A. Fuccillo; Jonas H. Ellenberg; John L. Sever

299

Topical anaesthesia with local anaesthetic (lidocaine and prilocaine, EMLA) cream for cautery of genital warts  

Microsoft Academic Search

Removal of genital warts by thermocautery was performed in 108 patients (57 men and 51 women) under topical anaesthesia with a local anaesthetic cream, lidocaine and prilocaine (EMLA). Most men had warts in the preputial cavity, most women had warts situated on the mucous membranes of the vulva, and warts at multiple sites were common. About 1 ml of cream

A Hallén; K Ljunghall; J Wallin

1987-01-01

300

Making Up Koro: Multiplicity, Psychiatry, Culture, and Penis-Shrinking Anxieties  

Microsoft Academic Search

Koro is a syndrome in which the penis (or sometimes the nipples or vulva) is retracting, with deleterious effects for the sufferer. In modern psychiatry, it is considered a culture-bound syndrome (CBS). This paper considers the formation and development of psychiatric conceptions of koro and related genital retraction syndromes from the 1890s to the present. It does so by examining

Ivan Crozier

2012-01-01

301

Making Up Koro: Multiplicity, Psychiatry, Culture, and Penis-Shrinking Anxieties  

Microsoft Academic Search

:Koro is a syndrome in which the penis (or sometimes the nipples or vulva) is retracting, with deleterious effects for the sufferer. In modern psychiatry, it is considered a culture-bound syndrome (CBS). This paper considers the formation and development of psychiatric conceptions of koro and related genital retraction syndromes from the 1890s to the present. It does so by examining

Ivan Crozier

2012-01-01

302

Genetic control of vulval development in Caenorhabditis briggsae.  

PubMed

The nematode Caenorhabditis briggsae is an excellent model organism for the comparative analysis of gene function and developmental mechanisms. To study the evolutionary conservation and divergence of genetic pathways mediating vulva formation, we screened for mutations in C. briggsae that cause the egg-laying defective (Egl) phenotype. Here, we report the characterization of 13 genes, including three that are orthologs of Caenorhabditis elegans unc-84 (SUN domain), lin-39 (Dfd/Scr-related homeobox), and lin-11 (LIM homeobox). Based on the morphology and cell fate changes, the mutants were placed into four different categories. Class 1 animals have normal-looking vulva and vulva-uterine connections, indicating defects in other components of the egg-laying system. Class 2 animals frequently lack some or all of the vulval precursor cells (VPCs) due to defects in the migration of P-cell nuclei into the ventral hypodermal region. Class 3 animals show inappropriate fusion of VPCs to the hypodermal syncytium, leading to a reduced number of vulval progeny. Finally, class 4 animals exhibit abnormal vulval invagination and morphology. Interestingly, we did not find mutations that affect VPC induction and fates. Our work is the first study involving the characterization of genes in C. briggsae vulva formation, and it offers a basis for future investigations of these genes in C. elegans. PMID:23275885

Sharanya, Devika; Thillainathan, Bavithra; Marri, Sujatha; Bojanala, Nagagireesh; Taylor, Jon; Flibotte, Stephane; Moerman, Donald G; Waterston, Robert H; Gupta, Bhagwati P

2012-12-01

303

Perinatal transmission of human papilomavirus DNA  

Microsoft Academic Search

The purpose was to study the perinatal transmission of human papillomavirus DNA (HPV-DNA) in 63 mother-newborn pairs, besides looking at the epidemiological factors involved in the viral DNA transmission. The following sampling methods were used: (1) in the pregnant woman, when was recruited, in cervix and clinical lesions of the vagina, vulva and perineal region; (2) in the newborn, (a)

Renato L Rombaldi; Eduardo P Serafini; Jovana Mandelli; Edineia Zimmermann; Kamille P Losquiavo

2009-01-01

304

Visual depictions of female genitalia differ depending on source  

Microsoft Academic Search

Very little research has attempted to describe normal human variation in female genitalia, and no studies have compared the visual images that women might use in constructing their ideas of average and acceptable genital morphology to see if there are any systematic differences. The objective of the present work was to determine if visual depictions of the vulva differed according

Helena Howarth; Volker Sommer; Fiona M Jordan

2010-01-01

305

Lichen sclerosus  

Microsoft Academic Search

Lichen sclerosus, usually appearing in the dermatologic literature under the names of lichen sclerosus et atrophicus, balanitis xerotica obliterans, and kraurosis vulvae, is an inflammatory disease with a multifactorial origin. A past association of lichen sclerosus and genital squamous cell carcinoma is not as close as once thought. Once considered primarily a surgical problem, especially when the genitals were involved,

Jeffrey J Meffert; Brian M Davis; Ronald E Grimwood

1995-01-01

306

Verification of the age of the Palaeolithic cave art at Creswell Crags, UK  

Microsoft Academic Search

Engravings representing Britain's first apparently Pleistocene cave art were discovered in Church Hole and Robin Hood caves, Creswell Crags. Representations of a deer, highly stylised females or birds and vulvae were engraved into the bedrock, and in some cases had been covered with a thin layer of flowstone. In the absence of radiocarbon datable pigments, uranium-series disequilibrium dating was undertaken

Alistair W. G. Pike; Mabs Gilmour; Paul Pettitt; Roger Jacobi; Sergio Ripoll; Paul Bahn; Francisco Muñoz

2005-01-01

307

Urogenital tumors  

SciTech Connect

An overview is provided for veterinary care of urogenital tumors in companion animals, especially the dog. Neoplasms discussed include tumors of the kidney, urinary bladder, prostate, testis, ovary, vagina, vulva and the canine transmissible venereal tumor. Topics addressed include description, diagnosis and treatment.

Weller, R.E.

1994-03-01

308

An Imported Case of Echinococcosis of the Liver in a Korean Who Traveled to Western and Central Europe  

PubMed Central

Echinococcus granulosus, an intestinal tapeworm of dogs and other canids, infects humans in its larval stage and causes human echinococcosis or hydatid disease. In the Republic of Korea, 31 parasite-proven human echinococcosis cases have been reported, most of which were imported from the Middle East. We recently examined a 61-year-old Korean man who had a large cystic mass in his liver. ELISA was negative for tissue parasitic infections, including echinococcosis, cysticercosis, paragonimiasis, and sparganosis. The patient underwent surgery to remove the cyst, and the resected cyst was processed histopathologically for microscopic examinations. In sectioned cyst tissue, necrotizing protoscolices with disintegrated hooklets of E. granulosus were found. In some areas, only freed, fragmented hooklets were detected. The patient had traveled to western and central Europe in 1996, and had no other history of overseas travel. We report our patient as a hepatic echinococcosis case which was probably imported from Europe.

Byun, Sun-Ju; Moon, Kyung Chul; Suh, Kyung-Suk; Han, Joon Koo

2010-01-01

309

Using community surveillance data to differentiate between emerging and endemic amphibian diseases.  

PubMed

We analyzed submission data from a wildlife care group during amphibian disease surveillance in Queensland, Australia. Between January 1999 and December 2004, 877 white-lipped tree frogs Litoria infrafrenata were classified according to origin, season and presenting category. At least 69% originated from urban Cairns, significantly more than from rural and remote areas. Total submissions increased during the early and late dry seasons compared with the early wet season. Frogs most commonly presented each year with injury, followed by 'other', sparganosis and irreversible emaciation of unknown aetiology. This is the first report of Spirometra erinacei infection in this species. A high prevalence (28%) of visible S. erinacei infection was found in emaciated frogs, but this was not statistically different from that in non-emaciated diseased frogs (25%). However, 14 emaciated specimens that were necropsied all had heavy S. erinacei infections, and the odds of visible sparganosis were statistically greater in emaciated frogs compared with injured, non-diseased frogs. We provide a detailed case definition for a new endemic disease manifesting as irreversible emaciation, for which S. erinacei may be the primary aetiological agent. The lack of significant spatial or temporal patterns in case presentation suggests that this is not a currently emerging disease. We show that community wildlife groups can play a valuable role in monitoring disease trends, particularly in urban areas, but identify a number of limitations associated with passive syndromic surveillance. We conclude that it is critical that professionals be involved in establishing syndromic case definitions, diagnostic pathology, complementary active disease surveillance, and data analysis and interpretation in all wildlife disease investigations. PMID:22422125

Young, Sam; Skerratt, Lee F; Mendez, Diana; Speare, Rick; Berger, Lee; Steele, Mike

2012-02-17

310

Successful treatment of wound breakdown caused by pyoderma gangrenosum after total knee arthroplasty.  

PubMed

Pyoderma gangrenosum is a rare ulcerative disorder of the skin of unknown etiology. We present a case of pyoderma gangrenosum that occurred following total knee arthroplasty, which was initially misdiagnosed as severe wound infection. Repeated debridement procedures resulted in a large soft tissue defect around the anterior knee joint. The patient was treated successfully with a latissimus dorsi musculocutaneous flap under immunosuppressive therapy. Pyoderma gangrenosum is often misdiagnosed as an infected wound, but the treatment for theses differential diagnoses is completely different. When a lesion is refractory to thorough treatment for infection, a diagnosis of pyoderma gangrenosum should be considered. PMID:20643552

Nakajima, N; Ikeuchi, M; Izumi, M; Kuriyama, M; Nakajima, H; Tani, T

2010-07-18

311

Nodular regenerative hyperplasia of the liver associated with systemic lupus erythematosus: three cases.  

PubMed

Nodular regenerative hyperplasia of the liver, characterised by regenerative nodules distributed throughout the liver in the absence of fibrosis, is a rare but important complication of systemic lupus erythematosus. The main consequence of nodular regenerative hyperplasia of the liver is non-cirrhotic portal hypertension. This condition is probably underdiagnosed, as many of these patients may remain asymptomatic. Furthermore, nodular regenerative hyperplasia of the liver may be misdiagnosed as cirrhosis. We describe three female patients with nodular regenerative hyperplasia of the liver associated with systemic lupus erythematosus. All three patients have clinical manifestations of portal hypertension, and all were initially misdiagnosed as having cryptogenic cirrhosis. PMID:19342741

Leung, Vincent K S; Loke, Tony K L; Luk, Ivy S C; Ng, W L; Chau, T N; Law, S T; Chan, James C S

2009-04-01

312

Perioral dermatitis -- the role of nasal steroids.  

PubMed

We present two patients with allergic rhinitis who developed perioral dermatitis (PD) after initiating intranasal steroid spray. Both patients had been previously misdiagnosed as having contact or seborrheic dermatitis, and therefore inappropriately and unsuccessfully treated with topical steroids. Physicians should be aware of this potential side effect of intranasal steroids to avoid incorrect therapeutic measures. In the setting of nasal steroids use, PD probably is an under-reported and commonly misdiagnosed condition that should be thought when a patient treated with nasal steroids present with small erythematous papules, papulovesicles, and papulopustules occurring against a background of redness, beginning in the nasolabial areas and spreading rapidly to the perioral zone. PMID:21995785

Peralta, Lígia; Morais, Paulo

2011-10-13

313

[X-ray differential diagnosis of focal tuberculosis and peripheral lung cancer].  

PubMed

The paper deals with the differential diagnosis of focal tuberculosis and peripheral lung cancer. It presents data on 25 patients of whom 24 were misdiagnosed as having focal tuberculosis. The main reason for misdiagnoses was the similarity of early X-ray symptoms of the two diseases, namely, upper lobar site, increased and thickened lung pattern and focal shadows against this background. The most important differentially diagnostic criteria for the above diseases are varying optic densities of pulmonary structures at the site of involvement and different patterns of vascular changes in the lung portion with a pathological process. PMID:10067353

Mamiliaev, R M

1998-01-01

314

Photodynamic therapy of vulvar lichen sclerosus et atrophicus in a woman with hypothyreosis--case report.  

PubMed

Lichen sclerosus et atrophicus (LSA) is disease of skin and mucosa, its pathogenesis remains unknown. Itching, pain and burning sensations and atrophy of vulva impair quality of life. Treatment is symptomatic. We report case of 30-year old woman with lesions in vulva in which series of topical PDT were carried out. We applied Levulan®Kerastick® for 4h and after that lesions were illuminated with red light. Along with above treatment patient started receiving Euthyrox®, because of recently diagnosed hypothyreosis. Significant relief from subjective symptoms was achieved and lesions in vulvar region disappeared. Combination of topical PDT with hormonal therapy allowed controlling course of disease and minimizing symptoms, and thus improved quality of life. PMID:22594990

Osiecka, B J; Nockowski, P; Jurczyszyn, K; Ziólkowski, P

2012-03-27

315

Urogenital atrophy.  

PubMed

The major cause of urogenital atrophy in menopausal women is estrogen loss. The symptoms are usually progressive in nature and deteriorate with time from the menopausal transition. The most prevalent urogenital symptoms are vaginal dryness, vaginal irritation and itching. The classical changes in an atrophic vulva include loss of labial and vulvar fullness, with narrowing of the introitus and inflamed mucosal surfaces. Dyspareunia and vaginal bleeding from fragile atrophic skin are common problems. Other urogenital complaints include frequency, nocturia, urgency, incontinence and urinary tract infections. Atrophic changes of the vulva, vagina and lower urinary tract can have a large impact on the quality of life of the menopausal woman. However, hormonal and non-hormonal treatments can provide patients with the solution to regain previous level of function. Therefore, clinicians should sensitively question and examine menopausal women, in order to correctly identify the pattern of changes in urogenital atrophy and manage them appropriately. PMID:19387880

Calleja-Agius, J; Brincat, M P

2009-08-01

316

[The female external genitalia : pathologic findings and first steps in treatment].  

PubMed

Symptoms of diseases of the female external genitalia are often expressed in pruritus and burning pain. To accomplish a targeted differential diagnosis an exact knowledge of anatomy is essential. An accurate anamnesis, a detailed inspection, and conducting a biopsy or microbiological smear lead to the correct diagnosis. Lichen sclerosus et atrophicus is the most common non-neoplastic disease of the vulva. This should be distinguished from amongst others lichen ruber planus, psoriasis, contact dermatitis of the vulva, or infectious diseases like condylomata acuminata, herpes genitalis, or mycosis.Preinvasive dysplastic alterations commonly cause symptoms comparable to benign diseases. Their appearance can be very heterogeneous. To avoid missing these conditions, it is often necessary to obtain a biopsy.Vulvar carcinoma occurs most frequently in the 8th decade. Nonetheless it should be included in differential diagnostic considerations in younger women since the incidence of the HP-positive variant is increasing in the younger age group. PMID:21107806

Goldnau, C; Köninger, A; Kimmig, R

2010-12-01

317

Two new species of Rhabdias (Nematoda: Rhabditida: Rhabdiasidae) in anuran hosts from Dehradun (Uttarakhand), India.  

PubMed

Rhabdias himalayanus n. sp. from the lungs of Duttaphrynus himalayanus and Rhabdias dehradunensis n. sp. from the lungs of Nanorana minica from Dehradun, India are described and figured. Of the 3 previously described Indian species, Rhabdias himalayanus n. sp. is most similar to Rhabdias shortii in having a cylindrical corpus, inflated cuticle, and conical tail; it differs from R. shortii in having greater body measurements, longer esophagus, larger eggs, and a different pattern of cuticle inflation at the vulva and tail region. Rhabdias dehradunensis n. sp. is most similar to Rhabdias bulbicauda in that both possess a swollen posterior end; it differs from R. bulbicauda by having a subterminal anus, a prominent tail, and a postequatorial vulva. PMID:23020804

Rizvi, Anjum N; Bursey, Charles R; Bhutia, Pasang T

2012-09-28

318

Magnetic resonance imaging of vulvar dermatofibrosarcoma protuberans - report of a case  

PubMed Central

Background Dermatofibrosarcoma protuberans (DFSP) of the vulva is a rare low-grade soft tissue sarcoma. Magnetic resonance imaging (MRI) findings of vulvar DFSP were essentially unreported in the literature. Case report We report a DFSP of vulva with its clinical, histological and MRI features. As far we know this is the first case of histologically confirmed vulvar DFSP presenting with MR images. The diagnosis of DFSP is usually made by histopathologic and clinical findings. Conclusions MRI is useful both for the diagnosis of DFSP and following up the patients since it has high soft tissue resolution and no risk of radiation exposure. With MRI the relation to the adjacent anatomical structures, extension and depth of the tumour and possible lymph node involvement can also be demonstrated.

Ozmen, Evrim; Guney, Guven; Algin, Oktay

2013-01-01

319

Comparison of incident cervical and vulvar/vaginal human papillomavirus infections in newly sexually active young women.  

PubMed

Vulvar/vaginal human papillomavirus (HPV) infections may precede cervical infections, and certain low-risk types may display vaginal tropism. We evaluated whether incident infections in young women display site-specific preferences by HPV risk group or phylogenetic species. Although incident infections were more likely to be detected in the vulva/vagina than in the cervix (odds ratio, 4.38 [95% confidence interval, 2.51-7.63]), the majority were first detected at both sites. Low- or undetermined-risk types were more likely than high-risk types to be first detected in the vulva/vagina (P = .03). Site-by-species differences were not statistically significant. Our results suggest that low- or undetermined-risk HPV types preferentially infect vaginal epithelium. PMID:19434913

Winer, Rachel L; Hughes, James P; Feng, Qinghua; O'Reilly, Sandra; Kiviat, Nancy B; Koutsky, Laura A

2009-03-15

320

A new species of Protrellus Cobb, 1920 (Nematoda, Thelastomatidae) parasite of the field cockroach Blatella vaga Hebard, 1919 (Blattodea, Blattidae) from Catamarca, Argentina.  

PubMed

A new species of the genus Protrellus, P. blatta sp. nov. parasitizing a field cockroach Blatella vaga Hebard, 1919, from El Tala river, Catamarca, Argentina, is described and illustrated. It is characterized by having the mouth opening circular, the buccal capsule with eight very small teeth, the nerve ring around oesophageal corpus, the excretory pore anterior to vulva, the vulva anterior to base of oesophagus, didelphic, the posterior ovary reflexed anterior to rectum, about one third of a body length from posterior end, the egg ellipsoidal, colourless, bearing a lateral cuticular crest, tail conical, with long filiform projection, the male with testis single, outstretched, one spicule, very small, short and straight, gubernaculums absent, the genital papillae arranged in three pairs of ventrolateral papillae, of which the first pair are close together and preanal position, two pairs postanal, tail conical and short, less than one twentieth of total body. A taxonomic key of Protrellus species is given. PMID:23377918

Camino, Nora B; de Villalobos, Cristina

2013-02-02

321

Description of Rhabdias breviensis n. sp. (Rhabditoidea: Rhabdiasidae) in two Neotropical frog species.  

PubMed

Nematodes of the genus Rhabdias Stiles & Hassall, 1905 (Rhabditoidea: Rhabdiasidae) have a dioecious free-living stage and a hermaphroditic stage that parasitises the lungs of amphibians and reptiles. Approximately 94 species of Rhabdias have been described. Because the similar morphological characteristics such as the labial structures, the location of the vulva and the shape of the tail of Rhabdias spp. hinder their identification, molecular biology techniques and scanning electron microscopy have been employed to diagnose species of this genus. This study describes Rhabdias breviensis n. sp., parasitic in the lungs of two Neotropical frog species Leptodactylus petersii Steindachner and Leptodactylus macrosternum Miranda-Ribeiro. The description of this species integrates classical taxonomy, scanning electron microscopy and a molecular analysis of the mitochondrial COI gene. The new species differs from all other Rhabdias species parasitic in Neotropical hosts in certain morphometric parameters, the position of the vulva, the host group and the cephalic characters. PMID:23949651

do Nascimento, Luciana de Cássia Silva; Gonçalves, Evonnildo Costa; Melo, Francisco Tiago de Vasconcelos; Giese, Elane Guerreiro; Furtado, Adriano Penha; dos Santos, Jeannie Nascimento

2013-08-15

322

Prognostic significance of lymph node variables and human papillomavirus DNA in invasive vulvar carcinoma  

Microsoft Academic Search

Objective. The present study investigates the influence of lymph node pathological features and HPV DNA status on the prognosis of vulvar invasive tumors.Methods. This study includes 184 consecutive cases of primary invasive squamous cell carcinoma of the vulva treated by radical surgery from 1975 to 1992, in São Paulo, Brazil. Clinical follow-up data was collected from patient files and hematoxilin–eosin

Álvaro P Pinto; Nicolas F. Schlecht; Javier Pintos; Jane Kaiano; Eduardo L. Franco; Christopher P. Crum; Luisa L. Villac

2004-01-01

323

Regulation of CD95 (APO1\\/ FAS) ligand and receptor expression in squamous-cell carcinoma by interferon-? and cisplatin  

Microsoft Academic Search

CD95 (Apo-1\\/Fas) ligand (CD95L) expression has been observed in various malignancies. In human primary cell lines from a squamous cell carcinoma (SCC) of the vulva, the effect of cisplatin (CDDP) and IFNg on the expression of CD95L and its 2 receptor isoforms, CD95 transmembrane (CD95tm) and CD95 soluble receptor, was studied at the mRNA and protein levels. Addition of CDDP

Cordula Moers; Ulrich Warskulat; Jos Even; Dieter Niederacher; Ursula Koldovsky; Matthias W. Beckmann

1999-01-01

324

External Anogenital Premalignant and Malignant Disease  

Microsoft Academic Search

The external anogenital area comprises the anus, perianal skin, and the adjacent external genitalia including the vulva and\\u000a vaginal introitus in the female, and the penis and scrotum in the male. Immunosuppressed organ transplant recipients (OTR)\\u000a are prone to viral infections, and have an increased incidence of human papillomavirus (HPV) associated premalignant and malignant\\u000a neoplasms, which specifically target the anogenital

Karen L. Gibbon; Arucha L. Ekeowa-Anderson; Irene M. Leigh

325

ARTICLES Clonal History of Papillomavirus-Induced Dysplasia in the Female Lower Genital Tract  

Microsoft Academic Search

Background: Dysplastic lesions of the vagina or the vulva often occur in women who have a previous history of cervical dysplasia. Most lesions in the female lower genital tract are induced by infections with high-risk oncogenic human papil- lomaviruses (HR-HPVs), including HPV16 and HPV18. HR-HPV genomes frequently integrate into host cell chromo- somes at random sites. We analyzed viral integration

Svetlana Vinokurova; Nicolas Wentzensen; Jens Einenkel; Ruediger Klaes; Corina Ziegert; Peter Melsheimer; Heike Sartor; Lars-Christian Horn; Michael Höckel; Magnus von Knebel Doeberitz

326

Human Papillomavirus-Specific Serologic Response in Vulvar Neoplasia  

Microsoft Academic Search

Epidemiological and virological evidence suggests that invasive squamous cell carcinoma (SCC) of the vulva is etiologically heterogeneous and that basaloid or warty SCC (BWSCC) and vulvar intraepithelial neoplasia (VIN) are linked to human papillomavirus (HPV) infections while keratinizing SCC (KSCC) is a non-HPV-associated malignancy. In the present study, HPV-specific antibodies in sera of patients with BWSCC, VIN, and KSCC and

Yeping Sun; Allan Hildesheim; Louise A. Brinton; Philip C. Nasca; Cornelia L. Trimble; Robert J. Kurman; Raphael P. Viscidi; Keerti V. Shah

1996-01-01

327

Pelvic Radiation in Women  

Microsoft Academic Search

\\u000a Pelvic radiation represents a major therapeutic strategy, either as adjuvant or primary treatment in the management of cancer\\u000a in women. This mainly concerns women with gynaecological malignancies: endometrial, cervical, vaginal, and vulva cancer; intestinal\\u000a malignancies: rectal and anal cancer, and bladder cancer. Further, long-term breast cancer survivors may experience similar\\u000a adverse effects after ovarian ablation accomplished by pelvic radiation. Finally,

Pernille T. Jensen

328

Vulvar Merkel Carcinoma: A Case Report  

PubMed Central

This is a new case of Merkel cell carcinoma of the vulva. It is a rare neuroendocrine carcinoma with an aggressive behavior. Because of its rarity in this location, it is not clear whether it behaves differently from the usual neuroendocrine carcinomas of the skin. A case of a 63-year-old patient with vulvar Merkel carcinoma is presented. The clinical presentation, microscopic and immunohistochemical features, and treatment are discussed.

Iavazzo, C.; Terzi, M.; Arapantoni-Dadioti, P.; Dertimas, V.; Vorgias, G.

2011-01-01

329

Circinate vulvitis in Reiter's syndrome.  

PubMed Central

Two cases of Reiter's syndrome in women are described. The diagnosis was based on the presence of increased vaginal and cervical discharge containing excess leucocytes, arthritis, conjunctivitis, and HLA B27 tissue-typing antigen. In addition circinate lesions developed on the vulva similar to those seen on the glans penis. No previous description of these lesions has been traced and the name 'circinate vulvitis' is suggested for these lesions. Images

Thambar, I V; Dunlop, R; Thin, R N; Huskisson, E C

1977-01-01

330

Icosiella turgeocauda n. sp. (Nematoda: Onchocercidae) and Seuratascaris numidica (Nematoda: Ascarididae), parasites of the frog, Rana cancrivora (Anura: Ranidae), from Luzon, Republic of the Philippines.  

PubMed

Icosiella turgeocauda n. sp. from the intestinal mesenteries of Rana cancrivora collected at Luzon, Republic of the Philippines, is described and illustrated. Icosiella turgeocauda n. sp. represents the ninth species to be assigned to the genus and is easily differentiated from all the previously described species by the position of the vulva and the presence of bilateral umbos on the caudal end of the male. Seuratascaris numidica also was found. The Philippines represents a new location record for S. numidica. PMID:12760651

Bursey, Charles R; Telford, Sam R; Goldberg, Stephen R

2003-04-01

331

Guidelines for the follow-up of women with vulvar lichen sclerosus in specialist clinics.  

PubMed

It is recommended that women with vulvar lichen sclerosus be followed in specialist clinics where difficulty exists with symptom control or where there is clinical evidence of localized skin thickening. Follow-up is also recommended for women who have previously been treated for squamous cell carcinoma of the vulva (arising in lichen sclerosus or vulvar intraepithelial neoplasia) or where the pathologist expresses concern and is unable to make a definitive diagnosis of differentiated vulvar intraepithelial neoplasia. PMID:17905173

Jones, Ronald W; Scurry, James; Neill, Sallie; MacLean, Allan B

2007-10-01

332

Genetic aberrations detected by comparative genomic hybridisation in vulvar cancers  

Microsoft Academic Search

Squamous cell carcinoma of the vulva is a disease of significant clinical importance, which arises in the presence or absence of human papillomavirus. We used comparative genomic hybridisation to document non-random chromosomal gains and losses within human papillomavirus positive and negative vulvar cancers. Gain of 3q was significantly more common in human papillomavirus-positive cancers compared to human papillomavirus-negative cancers. The

D G Allen; A-M Hutchins; F Hammet; D J White; J P Scurry; S N Tabrizi; S M Garland; J E Armes

2002-01-01

333

THE PAH COMPOSITION IN LIMPETS (PATELLA VULGATA L.) FROM THE COASTS OF SICILY (ITALY)  

Microsoft Academic Search

This article examines the presence, distribution, nature and sources of 19 Polycyclic Aromatic Hydrocarbons (PAH), in Patellae (patella vulgate L.) and seaweed (vulva) sampled in different stations of Sicilian coastal environments and analyzed for their polycyclic aromatic hydrocarbon (PAH) content.Analysis was performed by gas chromatography\\/mass spectrometry (GC\\/MS) with selected ion monitoring (SIM), after saponification of the sample and clean up

Antonio Gianguzza; Santino Orecchio

2006-01-01

334

A v-erbB-Related Protooncogene, c-erbB-2, is Distinct from the c-erbB-1\\/Epidermal Growth Factor-Receptor Gene and is Amplified in a Human Salivary Gland Adenocarcinoma  

Microsoft Academic Search

From a human genomic library, we obtained six v-erbB-related DNA clones. A DNA probe prepared from one of the clones, lambda 107, hybridized to EcoRI fragments of 6.4 and 13 kilobase pairs of human DNA. Neither of these fragments was amplified in A431 vulva carcinoma cells, in which the gene encoding the epidermal growth factor receptor is amplified. In addition,

Kentaro Semba; Nobuyuki Kamata; Kumao Toyoshima; Tadashi Yamamoto

1985-01-01

335

Comparison of peroxidase-labeled DNA probes with radioactive RNA probes for detection of human papillomaviruses by in situ hybridization in paraffin sections  

Microsoft Academic Search

A study comparing in situ hybridization using nonradioactive DNA probes directly conjugated with horseradish peroxidase (HRP), and ³⁵S-labeled antisense RNA probes for human papillomavirus (HPV) types 6\\/11, 16, and 18 was performed on formalin-fixed, paraffin-embedded tissue from 34 lesions of the cervix and vulva. These lesions included exophytic condylomas and intraepithelial and invasive neoplasms. HPV 6\\/11 was detected in two

J. S. Park; R. J. Kurman; T. D. Kessis; K. V. Shah

1991-01-01

336

Female Genital Surgery  

Microsoft Academic Search

\\u000a Our society attributes great importance to appearance and body image. In the recent past, cosmetic vulvar plastic surgery\\u000a has been widely introduced in the western world. Modification of the cultural environment and increasing vulvar “visibility”\\u000a have generated the erroneous identification of an ideally “normal” appearing vulva. The links between partner’s relationship,\\u000a sexuality, and body image have become more strict, and

Francesca De Lorenzi; Elena Mascolo; Francesca Albani; Mario Sideri

337

Cylicospirura advena n.sp. (Nematoda: Spirocercidae) a stomach parasite from a cat in New Zealand, with observations on related species  

Microsoft Academic Search

Summary  \\u000aCylicospirura (Cylicospirura) advena n.sp. described from specimens obtained from a feral cat in New Zealand is characterized by the presence of toothless rounded knobs on the anterior ends of the longitudinal supporting ribs in the buccal capsule; a vulva either anterior or posterior to the oesophago-intestinal junction; its small size (less than 6 mm) and the presence of a

W. C. Clark

1981-01-01

338

LET23 Receptor Localization by the Cell Junction Protein LIN7 during C. elegans Vulval Induction  

Microsoft Academic Search

In C. elegans, the anchor cell signal induces Pn.p cells to form the vulva by activating a conserved receptor tyrosine kinase pathway. lin-2 and lin-7 mutants exhibit a vulvaless phenotype similar to the phenotype observed when this signaling pathway is defective. We have found that LIN-7 is a cell junction–associated protein that binds to the LET-23 receptor tyrosine kinase. LET-23

Jeffrey S Simske; Susan M Kaech; Stacey A Harp; Stuart K Kim

1996-01-01

339

Risk factors for short- and long-term complications after groin surgery in vulvar cancer  

Microsoft Academic Search

Background:The cornerstone of treatment in early-stage squamous cell carcinoma (SCC) of the vulva is surgery, predominantly consisting of wide local excision with elective uni- or bi-lateral inguinofemoral lymphadenectomy. This strategy is associated with a good prognosis, but also with impressive treatment-related morbidity. The aim of this study was to determine risk factors for the short-term (wound breakdown, infection and lymphocele)

F. Hinten; L. C. G. van den Einden; J. C. M. Hendriks; A. G. van der Zee; J. Bulten; L. F. A. G. Massuger; H. P. van de Nieuwenhof; J. A. de Hullu

2011-01-01

340

Vulvar squamous cell carcinoma associated with Fanconi's anemia.  

PubMed

Fanconi's anemia is a rare autosomal recessive disorder which is rarely associated with squamous cell carcinoma (SCC) of the vulva. We report a 23-year-old virgin female with Fanconi's anemia and diabetes mellitus who presented with a history of 6-month ulcerative lesions of the vulva. Gynecologic examination disclosed a 1 x 2 cm ulcerated tumor lesion at the right labia minor near to the urethra. The biopsy showed a high-grade vulvar intraepithelial neoplasia (VIN III). She underwent wide local excision for this lesion. Pathologic examination of the surgically removed specimen revealed SCC of the vulva. Therefore, radical vulvectomy and bilateral inguino-femoral lymphadenectomy were performed. Due to the involvement of right inguinal lymph node, radiotherapy with a total dose of 45 Gy was delivered to mid-pelvis through antero-posterior/postero-anterior fields with 18 mV photon energies. Until her last follow-up about 1 year after the treatment, the patient was free of disease or any recurrence at the site of operation. Patients with Fanconi's anemia have the risk of developing SCC of the genital tract. Radical vulvectomy and lymphadenectomy along with radiotherapy were associated with a satisfactory outcome in 1-year follow-up period in the presented patient. PMID:20217286

Mousavi, Azamsadat; Abbasi, Fatemeh; Abadi, Akram Ghahghai Nezam; Hashemi, Farnaz Amouzegar

2010-03-10

341

Pure vulvar Langerhans cell histiocytosis: a case report and literature review.  

PubMed

Langerhans cell histiocytosis (LCH) of the female genital tract is a very rare disease. Only 16 cases of primary vulvar LCH without subsequent systemic spread of disease have previously been published in the literature. We describe an additional case of LCH in which the lesion was confined to the vulva. A 52-year-old Caucasian woman presented for further investigation with a 6-month history of vulvar pruritus. Physical examination revealed multiple fine red papules on both labia minor. A metastatic workup did not reveal any evidence of disease beyond the vulva. The lesion was biopsied, and histological findings were characteristic of LCH. The patient was treated by local extirpation of both labia minor. Ten months after surgery, the patient has no signs of local recurrence or systemic spread. It is necessary to perform a biopsy of the lesions when a woman presents atypical chronic lesions on the vulva. Although different treatment has been proposed, complete surgical excision is fundamental in "pure" genital Langerhans cell histiocytosis as initial therapy. PMID:20099508

Triantafyllidou, O; Giannakopoulos, K; Pergialiotis, V; Simou, M; Lagkadas, A; Alexandrou, P

2009-01-01

342

Identifying Hearing Loss in Young Children: Technology Replaces the Bell  

ERIC Educational Resources Information Center

|Hearing loss can too easily be misdiagnosed or overlooked by providers serving young children. Parents and professionals may observe a language delay--an "invisible" condition--while failing to identify the underlying cause. Otoacoustic emissions (OAE) hearing screening technology, used extensively with newborns, is becoming an essential tool,…

Eiserman, William; Shisler, Lenore

2010-01-01

343

Citizenship Norms and the Expansion of Political Participation  

Microsoft Academic Search

A growing chorus of scholars laments the apparent decline of political participation in America, and the negative implications of this trend for American democracy. This article questions this position - arguing that previous studies misdiagnosed the sources of political change and the consequences of changing norms of citizenship for Americans' political engagement. Citizenship norms are shifting from a pattern of

Russell J. Dalton

2008-01-01

344

Anxiety in children and adolescents with Autism Spectrum Disorders  

Microsoft Academic Search

Anxiety symptoms and disorders are highly prevalent in children and adolescents with Autism Spectrum Disorder (ASD), although they are often unrecognized or misdiagnosed. The purpose of the present review is to (1) provide clinicians with practical information on assessment and diagnosis of co-morbid anxiety in children and adolescents with ASD, (2) summarize and critically examine the literature on anxiety in

Bonnie M. MacNeil; Vicki A. Lopes; Patricia M. Minnes

2009-01-01

345

The Impact of Maternal Depressive Symptomatology on Ratings of Children with ADHD and Child Confederates  

ERIC Educational Resources Information Center

Some researchers who have studied children with behavior problems have suggested that depressed mothers distort reports of deviance in their children, perhaps contributing to misdiagnoses; however, investigations studying mothers with current or past depression have not clearly indicated such a bias. Because some of this equivocation may be due to…

Baumann, B. L.; Pelham Jr., W. E.; Lang, A. R.; Jacob, R. G.; Blumenthal, J. D.

2004-01-01

346

An unrecognized cause of paralysis in ED: Thyrotoxic normokalemic periodic paralysis  

Microsoft Academic Search

Hypokalemic paralysis associated with hyperthyroidism (TPP) is a well-known acute electrolyte and muscle function disorder. Lesser known is normokalemic periodic paralysis associated with hyperthyroidism. We describe two cases of young men with acute muscular paralysis and bilateral impairment of sensation over the lower legs who had normal plasma potassium concentrations. They were initially misdiagnosed as having Guillain-Barré syndrome or hysterical

Chia-Chao Wu; Tom Chau; Chao-Jiieh Chang; Shih-Hua Lin

2003-01-01

347

Aberrant expression of epithelial and neuroendocrine markers in alveolar rhabdomyosarcoma: a potentially serious diagnostic pitfall  

Microsoft Academic Search

Alveolar rhabdomyosarcoma may be extremely difficult to distinguish from other primitive round cell neoplasms without ancillary immunohistochemistry and\\/or genetic study. Particularly in adults and in the head and neck locations, the differential diagnosis of alveolar rhabdomyosarcoma includes small cell carcinoma and neuroepithelial tumors, such as esthesioneuroblastoma. We have recently seen cases of genetically confirmed alveolar rhabdomyosarcoma, which were misdiagnosed owing

Armita Bahrami; Allen M Gown; Geoffrey S Baird; M John Hicks; Andrew L Folpe

2008-01-01

348

North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition Consensus Statement on the Diagnosis and Management of Cyclic Vomiting Syndrome  

Microsoft Academic Search

Cyclic vomiting syndrome (CVS) is a disorder noted for its unique intensity of vomiting, repeated emergency department visits and hospitalizations, and reduced quality of life. It is often misdiagnosed due to the unappreciated pattern of recurrence and lack of confirmatory testing. Because no accepted approach to management has been established, the task force was charged to develop a report on

B UK Li; Frank Lefevre; Gisela G Chelimsky; Richard G Boles; Susanne P Nelson; Donald W Lewis; Steven L Linder; Robert M Issenman; Colin D Rudolph

2008-01-01

349

A case of adult-onset Satoyoshi syndrome with gastric ulceration and eosinophilic enteritis  

Microsoft Academic Search

Background The patient was misdiagnosed as having Sjögren's syndrome (on the basis of a lower-limb rash and dry eyes and mouth) in 1999, and then as having systemic lupus erythematosus (on the basis of hair loss and a high antinuclear antibody titer) in 2005. Total alopecia, muscular spasms and diarrhea developed over the following 2 years, and the patient experienced

Ronald A Asherson; Dominic Giampaolo; Michael Strimling

2008-01-01

350

La pyomyosite : une complication infectieuse du lupus érythémateux systémique  

Microsoft Academic Search

Pyomyositis is a primary pyogenic muscular infection. It has been originally described in the tropics. Presenting signs and symptoms are not specific. It is frequently misdiagnosed in the early stages. We report the case of a 47-year-old woman with systemic lupus erythematosus treated with corticosteroids who presented a thigh pyomyositis evidenced by echography and MRI. Outcome was uneventful after antibiotics

M. El Baaj; F. Tabache; K. Modden; H. Hassikou; S. Safi; R. Khalid; L. Hadri

2010-01-01

351

When good news is bad news: psychological impact of false positive diagnosis of HIV  

Microsoft Academic Search

HIV testing is known to be stressful, however the impact of false positive HIV results on individuals is not well documented. This is a series of four case who developed psychological difficulties and psychiatric morbidities after being informed they had been misdiagnosed with HIV-positive status. We look into documented cases of misdiagnosis and potential risks of misdiagnosis. The case series

Rahul Bhattacharya; Simon Barton; Jose Catalan

2008-01-01

352

Tinea incognito due to microsporum gypseum  

Microsoft Academic Search

A 41-year-old woman presented with a pruritic rash on the face that was of 3 months duration. During that time, it had been successively misdiagnosed as psoriasis vulgaris, systemic lupus erythematosus, facial dermatitis at other hospitals, and had been treated with agents that included acitretin and prednisone. Finally, fungi were found in the lesions by optical microscopy, and the fungal

Chunshui Yu; Jingguo Zhou; Jianping Liu

2010-01-01

353

Progressive pseudorheumatoid arthritis of childhood (PPAC)  

Microsoft Academic Search

Five patients are described with a hereditary arthropathy affecting major and minor joints. The main features of this progressive connective tissue disorder are restricted joint mobility, osseous swelling of the interphalangeal and other joints, and platyspondyly. The condition is commonly misdiagnosed as “chronic juvenile polyrthritis with Scheuermann disease”. It differs from the rheumatoid-factor-negative polyarticular form of rheumatoid arthritis and other

J. Spranger; C. Albert; F. Schilling; C. Bartsocas; H. Stöss

1983-01-01

354

A case of lupus peritonitis and cystitis after ovulation induction therapy.  

PubMed

We report a patient in whom lupus peritonitis and cystitis developed after ovulation induction therapy with human menopausal and chorionic gonadotropins followed by in vitro fertilization and embryo transfer. The lupus peritonitis and cystitis presented clinically as an acute abdomen. This disease should not be misdiagnosed as a nonspecific or infectious pelvic peritonitis, especially after oocyte retrieval. PMID:14526338

Tsunoda, Sei; Takano, Hirohisa; Inoue, Ken-ichiro; Yoshikawa, Toshikazu

2003-09-01

355

Creating a mutual gains climate regime through universal clean energy services  

Microsoft Academic Search

Climate change is a serious threat to all nations. This raises the question of why continuous treaty negotiations for more than two decades have failed to create a viable or adequate international climate regime. The current strategy of addressing climate change misdiagnoses the issue as a pollution problem by focusing on symptoms (emissions) and not on underlying causes (unsustainable development).

William Moomaw; Mihaela Papa

2012-01-01

356

[Iatrogenic internal carotid artery pseudoaneurysm as a complication of myryngotomy in 6-years-old boy].  

PubMed

The aberrant internal carotid artery (ICA) is a rare congenital vascular anomaly. Misdiagnosed may result in life threatening complications during middle ear surgery. Authors present a case of a 6-year old boy in whom ventilation tube insertion was complicated by ICA pseudo-aneurysm formation. Symptoms, diagnosis and management of ICA pseudo-aneurysm are discussed. PMID:23036129

Kaczorowska, Ma?gorzata; Furmanek, Mariusz I; Klimek, Paulina; Skar?y?ski, Henryk

2012-06-09

357

Dissociative Disorders in Children: Behavioral Profiles and Problems.  

ERIC Educational Resources Information Center

Clinical research has established a connection between childhood trauma and the development of dissociative disorders in adults. Pathological dissociation produces a range of symptoms and behaviors such as amnesias, rapid shifts in mood and behavior, and auditory and visual hallucinations. Many of these symptoms are misdiagnosed as attention,…

Putnam, Frank W.

1993-01-01

358

High-Performing Families: Causes, Consequences, and Clinical Solutions. The Family Psychology and Counseling Series.  

ERIC Educational Resources Information Center

This book explores the dilemma of the increasing obsession with work and the resulting imbalances between career and family life. Through theoretical frameworks and case examples it discusses the negative consequences of the societal phenomena of over-work and over-dedication to careers, which have been misdiagnosed or ignored by mental health…

Robinson, Bryan E., Ed.; Chase, Nancy D., Ed.

359

Intimal sarcoma of the pulmonary artery: Report of an autopsy case  

Microsoft Academic Search

Primary pulmonary artery sarcomas (PASs) are rare and lethal tumors. They are easily misdiagnosed as chronic pulmonary embolism, mediastinal mass or tumor emboli, which delay a proper treatment. Although the advanced technologies are now increasingly being used, their diagnosis is usually hard to establish preoperatively at the present time. We report here a case of a 68-year-old female with PAS

Shiro Miura; Serik Meirmanov; Masahiro Nakashima; Tomayoshi Hayashi; Kuniko Abe; Naoe Tamaru; Yoshiyuki Miyahara; Ichiro Sekine

2005-01-01

360

Acute Kidney Infarction Secondary to Intracardiac Thrombus Embolization in a Patient with Ischemic Dilated Cardiomyopathy  

Microsoft Academic Search

Acute renal infarction due to emboli represents a very rare but significant threat for kidney loss, and the clinical presentation is challenging. The differential diagnosis of massive renal thrombi includes all other causes of abdominal pain, and they can be easily misdiagnosed as renal colic due to nephrolithiasis. Although there are a few case reports regarding the possibility that cardiac

Mehmet Mustafa Can; Hacer Ceren Demircan; Alper Özkan; Fatih Koca; Kenan Sönmez; Cihangir Kaymaz; Victor Serebruany

2010-01-01

361

Tracheal mucoepidermoid carcinoma in a 7-year-old child  

Microsoft Academic Search

Mucoepidermoid cancers are rare tumors that arise from the serous and mucous glands of the upper airway and salivary glands. Patients, especially children, with tumors that arise in the trachea and upper airways are often misdiagnosed as asthmatic and are treated with bronchodilators without resolution. A 7-year-old girl who had been diagnosed as asthmatic was subsequently found to have a

Seiichi Noda; Sudhir Sundaresan; Eric N Mendeloff

1998-01-01

362

Male Anorexia Nervosa: A New Focus.  

ERIC Educational Resources Information Center

|Although anorexia nervosa affects over one million males yearly, it is often misdiagnosed or overlooked by mental health and medical practitioners. This article brings the problem to the forefront and outlines features that are unique to these males. Greater recognition of the disorder can lead to more accurate diagnoses and, subsequently, better…

Crosscope-Happel, Cindy; Hutchins, David E.; Getz, Hildy G.; Hayes, Gerald L.

2000-01-01

363

Draw-a-Story: Screening for Depression and Age or Gender Differences.  

ERIC Educational Resources Information Center

There is an urgent need for early identification of depressed individuals so that they may be found and helped in time. Childhood depression is often masked by problems in school, and as a result, these children usually go undiagnosed or misdiagnosed. It has been found that drawings by depressed patients have distinct patterns which are rated…

Silver, Rawley

364

A Prospective Study of Acute-Onset Steroid Acne Associated with Administration of Intravenous Corticosteroids  

Microsoft Academic Search

Steroid acne (SA) may occur after the administration of topical or systemic corticosteroids. Because of several consultations of spinal injury patients with a very abrupt onset of a uniform papular eruption (i.e. days) initially misdiagnosed as a drug reaction or sepsis, we followed hospitalized patients who received intravenous corticosteroids (IVC) for the development of acute-onset SA in order to determine

Maxwell A. Fung; Timothy G. Berger

2000-01-01

365

Preventing Chronic Obstructive Pulmonary Disease: What Is Known and What Needs to Be Done to Make a Difference to the Patient?  

Microsoft Academic Search

Chronic obstructive pulmonary disease (COPD) is a preventable and treatable systemic disease with symptoms that overlap other respiratory illnesses. An estimated 24 million adults in the United States have COPD, but >50% of them are misdiagnosed or undiagnosed. Spirometry remains the “gold standard” for diagnosing COPD and for monitoring the progression of the disease. Cigarette smoking is the main cause

Robert A. Wise; Donald P. Tashkin

2007-01-01

366

Toward Understanding Ethnic and Cultural Factors in the Interviewing Process  

Microsoft Academic Search

The clinical interview is critical in the diagnostic assessment undertaking in clinical settings, and cultural\\/ethnic influences have been shown to influence the outcome of this process. Specifically, a number of studies have reported that proportionally far more ethnic minorities than Caucasians are likely to be misdiagnosed when assessed for psychiatric disorders. This particularly is the case when open clinical interviews

Will M. Aklin; Samuel M. Turner

2006-01-01

367

Acute aortic dissection: be aware of misdiagnosis  

Microsoft Academic Search

BACKGROUND: Acute aortic dissection (AAD) is a life-threatening condition requiring immediate assessment and therapy. A patient suffering from AAD often presents with an insignificant or irrelevant medical history, giving rise to possible misdiagnosis. The aim of this retrospective study is to address the problem of misdiagnosing AD and the different imaging studies used. METHODS: From January 2000 to December 2004,

Irene Asouhidou; Theodora Asteri

2009-01-01

368

ECONOMIC POLICY AND THE FINANCIAL CRISIS: AN EMPIRICAL ANALYSIS OF WHAT WENT WRONG  

Microsoft Academic Search

The financial crisis was in large part caused, prolonged, and worsened by a series of government actions and interventions. The housing boom and bust that precipitated the crisis were enabled by extraordinarily loose monetary policy. After the housing boom came to an end, the Federal Reserve misdiagnosed financial markets' uncertainty about the location and value of risky subprime mortgage?backed securities

John B. Taylor

2009-01-01

369

The use of Mood Disorder Questionnaire, Hypomania Checklist32 and clinical predictors for screening previously unrecognised bipolar disorder in a general psychiatric setting  

Microsoft Academic Search

Bipolar disorder is often unrecognised and misdiagnosed in the general psychiatric setting. This study compared the psychometric properties of Mood Disorder Questionnaire (MDQ) and Hypomania Checklist-32 (HCL-32), examined the clinical predictors of bipolar disorder and determined the best approach for screening previously unrecognised bipolar disorder in a general psychiatric clinic. A random sample of 340 non-psychotic outpatients with no previous

Yvette Poon; Ka-Fai Chung; Kwok-Chu Tso; Chi-Lok Chang; Dorothy Tang

370

BIPOLAR DISORDER: MAKING THE DIAGNOSIS AND EXPLORING THE BIOLOGICAL ORIGINS  

Microsoft Academic Search

By conservative estimates, bipolar disorder affects 2.3 million Americans, and is frequently misdiagnosed, with individuals reporting seeing an average of 4 physicians before receiving the proper diagnosis and treatment. This may be due to the fact that the symptoms of bipolar disorder comprise a mood spectrum, running the gamut from depressive episodes to mania, with periods of euthymia and, in

Scott P. Hoopes

371

Tubes, lines, catheters, and other interesting devices  

Microsoft Academic Search

Medical devices (tubes, catheters, lines, prostheses, etc.) are a common finding on radiologic studies. Sometimes they may be misdiagnosed as a pathologic process, or an important observation concerning a medical device may be overlooked because of lack of familiarity with a particular device. This review discusses a variety of tubes, lines, catheters, and other interesting and important medical devices found

Tim B. Hunter

1995-01-01

372

Electroencephalography in clinical epilepsy research  

Microsoft Academic Search

Electroencephalography (EEG) remains central to the investigation of epilepsy. This review discusses two clinical problems at the temporal extremes of neurophysiologic recording: evaluation of the clinical significance of individual spike discharges in benign epilepsy of childhood with centrotemporal spikes (BECTS), and prolonged (several days) continuous EEG monitoring in the ICU. BECTS is misdiagnosed often, and probably mis-treated often as well.

Susan T. Herman; Masanori Takeoka; John R. Hughes; Frank W. Drislane

2011-01-01

373

Personality Differences on the Rorschach of Dissociative Identity Disorder, Borderline Personality Disorder, and Psychotic Inpatients  

Microsoft Academic Search

Patients with dissociative identity disorder (DID) are often diagnosed with borderline personality disorder (BPD) and misdiagnosed with psychotic illnesses. This study is designed to determine whether the Rorschach protocols of 67 patients with DID differ from those of 40 patients with BPD and 43 patients with psychotic disorder (PSD) in variables reflecting capacity for working alliance, complexity of experience, and

Bethany L. Brand; Judith G. Armstrong; Richard J. Loewenstein; Scot W. McNary

2009-01-01

374

Sentence Repetition as a Measure of Morphosyntax in Monolingual and Bilingual Children  

ERIC Educational Resources Information Center

|Bilingual children are frequently misdiagnosed as having Specific Language Impairment (SLI). Misdiagnosis may be minimized by tests with high degrees of sensitivity and specificity. The current study used a new test, the School-Age Sentence Imitation Test-English 32 (SASIT-E32), to investigate sentence repetition in monolingual and bilingual…

Komeili, Mariam; Marshall, Chloe R.

2013-01-01

375

Anisakiasis and Gastroallergic Reactions Associated with Anisakis pegreffii Infection, Italy  

PubMed Central

Human cases of gastric anisakiasis caused by the zoonotic parasite Anisakis pegreffii are increasing in Italy. The disease is caused by ingestion of larval nematodes in lightly cooked or raw seafood. Because symptoms are vague and serodiagnosis is difficult, the disease is often misdiagnosed and cases are understimated.

Fazii, Paolo; De Rosa, Alba; Paoletti, Michela; Megna, Angelo Salomone; Glielmo, Antonio; De Angelis, Maurizio; Costa, Antonella; Meucci, Costantino; Calvaruso, Vito; Sorrentini, Italo; Palma, Giuseppe; Bruschi, Fabrizio; Nascetti, Giuseppe

2013-01-01

376

Pathological Motion Detection for Robust Missing Data Treatment  

Microsoft Academic Search

This paper presents a new missing data detection algorithm that is robust to Pathological Motion (PM). PM causes clean image data to be misdiagnosed as missing data, resulting in damage to the image during restoration. The proposed algorithm uses a probabilistic framework to jointly detect PM and missing data. It builds on an existing technique of using five frames for

David Corrigan; Naomi Harte; Anil C. Kokaram

2008-01-01

377

Design of a molecular method for subspecies specific identification of Klebsiella pneumoniae by using the 16S ribosomal subunit gene  

Microsoft Academic Search

SUMMARY Introduction: Rhinoscleroma is caused by Klebsiella pneumoniae subsp. rhinoscleromatis and the ozena infections caused by K. pneumoniae subsp. ozaenae, both infections affect the upper respiratory tract. In the first clinical phases the symptoms are unspecific, and the disease can be misdiagnosed as a common cold, therefore antimicrobial therapy cannot reach effective results and patients must be following up for

NELSON ENRIQUE ARENAS; J UAN CARLOS POLANCO; SANDRA MILENA CORONADO; QM CLARA JULIANA DURANGO; ARLEY GÓMEZ

378

Uncommon cause of acute abdominal pain at the emergency room: epiploic appendagitis.  

PubMed

This is a case of 49 year-old-female with left lower quadrant pain. Initial diagnosis of acute diverticulitis entertained and treated accordingly. Diagnosis of epiploic appendagitis was done by abdominal CT-Scan. Epiploic appendagitis is commonly misdiagnosed as diverticulitis and appendicitis. Non-invasive studies may lead to early diagnosis avoiding unnecessary hospitalizations, antibiotic therapy and surgical intervention. PMID:21696102

Maldonado-Rivera, Sandra N; Calviño-Acosta, Lázaro; Santiago-Casiano, Mónica; de Lourdes Miranda, María; Mercedes Maldonado, Milciades; Hernan Martínez, José

379

Appendectomy due to lead poisoning: a case-report  

Microsoft Academic Search

BACKGROUND: Lead poisoning is a common occupational health hazard in developing countries and many misdiagnoses and malpractices may occur due to unawareness of lead poisoning symptoms. CASE PRESENTATION: We report a case of occupational lead poisoning in an adult battery worker with abdominal colic who initially underwent appendectomy with removal of normal appendix. Later on he was diagnosed with lead

S Mohammadi; AH Mehrparvar; M Aghilinejad

2008-01-01

380

Misdiagnosis of Alzheimer's Disease: Case Studies in Capacity Assessment  

Microsoft Academic Search

The intense focus on Alzheimer's disease has led even experienced practitioners to misdiagnose older adults' cognitive impairment as Alzheimer's. The impact of misdiagnosis may be greatest in cases of capacity, especially conservatorship and testamentary capacity. Two case examples are presented, with an emphasis on diagnostic issues and the importance of accurate diagnosis in light of increasing cases of cognitive dysfunction

Peter A. Lichtenberg

2012-01-01

381

Scrotal calcinosis: is it idiopathic or dystrophic?  

Microsoft Academic Search

Background: Scrotal calcinosis is an uncommon lesion characterized by multiple calcific deposits within scrotal skin and often misdiagnosed clinically as epidermal cyst. Case: In this article, we described a scrotal calcinosis in a 19-year-old man in whom calcified nodules without evidence of epithelialize d lining were seen both in de rmis and within the bundles of dartos muscle. Additionally, these

Esra Canan Kelten; Metin Akbulut; Nagihan Çolakoglu; Hatice Bayramoglu; S. Ender

2005-01-01

382

Depersonalization: Standing in the Spaces Between Recognition and Interpellation  

Microsoft Academic Search

Depersonalization is the experience of profound estrangement and alienation from Self and Reality. Although highly prevalent in our postmodern world, the syndrome of depersonalization has been systematically understudied, misdiagnosed, and unsuccessfully treated. In this paper we summarize our theoretical conclusions after a decade-long empirical study of this population and discuss both etiology and recommendations for treatment. Our main objective here

Orna Guralnik; Daphne Simeon

2010-01-01

383

Chronic abdominal wall pain: Clinical features, health care costs, and long-term outcome  

Microsoft Academic Search

Background & Aims: Chronic abdominal wall pain (CAWP) often is misdiagnosed. We evaluated CAWP patients regarding diagnosis accuracy, clinical features, comorbidity, referral frequency, use of care, and long-term outcome. Methods: We reviewed the records of all outpatients referred to a gastroenterologist in 5 years, recorded referral indications, and identified patients initially diagnosed with CAWP or irritable bowel syndrome (IBS). Charts

Christopher D Costanza; George F Longstreth; Amy L Liu

2004-01-01

384

Glycogen Storage Diseases Presenting as Hypertrophic Cardiomyopathy  

Microsoft Academic Search

background Unexplained left ventricular hypertrophy often prompts the diagnosis of hypertrophic cardiomyopathy, a sarcomere-protein gene disorder. Because mutations in the gene for AMP-activated protein kinase g 2 ( PRKAG2 ) cause an accumulation of cardiac glycogen and left ventricular hypertrophy that mimics hypertrophic cardiomyopathy, we hypoth- esized that hypertrophic cardiomyopathy might also be clinically misdiagnosed in pa- tients with other

Michael Arad; Barry J. Maron; Joshua M. Gorham; Walter H. Johnson; J. Philip Saul; Antonio R. Perez-Atayde; Paolo Spirito; Gregory B. Wright; Ronald J. Kanter; Christine E. Seidman; J. G. Seidman

2010-01-01

385

Giant congenital aortic aneurysm with cleft sternum in a neonate: pathological and surgical considerations for optimal management  

Microsoft Academic Search

We report a rare case of a neonate with congenital giant aortic aneurysm associated to cleft sternum, who underwent surgical repair. The patient died on postoperative Day 5 from cardiac arrest. Autopsy revealed a circumferential subendocardial myocardial infarction and misdiagnosed coronary ostial anomalies. A critical analysis of this unfortunate case may help optimal surgical planning in similar patients in the

Massimo A. Padalino; Giovanni Stellin; Gaetano Thiene; Maurizio Rubino; Stefania Rizzo; Ornella Milanesi; Cristina Basso

2010-01-01

386

Polycystic Ovary Syndrome: A Review of Current Knowledge  

Microsoft Academic Search

Polycystic ovarian syndrome (PCOS) is the most common endocrine disease of women of reproductive age, yet it remains undiagnosed for many women. The reason the syndrome is often not diagnosed or is misdiagnosed is because PCOS can present with a variety of abnormalities that can be present in other endocrine dysfunctions and problems. Concerns about abnormal menses, an inability to

Elizabeth DuRant; Nan S. Leslie

2007-01-01

387

Quantitative Assessment of Brainstem Development in Joubert Syndrome and Dandy-Walker Syndrome  

Microsoft Academic Search

Key features of Joubert syndrome include developmental delay, hypotonia, hyperpnea and apnea, oculomotor apraxia, and the presence of the molar tooth sign on axial imaging through the brainstem isthmus—the junction of the pons and mesencephalon. Interestingly, 1 in 10 patients with Joubert syndrome has abnormal cerebrospinal fluid collections misdiagnosed as Dandy-Walker variants. Because of important differences in patient management, genetic

Bernard L. Maria; Alilreza Bozorgmanesh; Kimberly N. Kimmel; Douglas Theriaque; Ronald G. Quisling

2001-01-01

388

Laboratory-acquired brucellosis.  

PubMed

We report two laboratory-acquired Brucella melitensis infections that were shown to be epidemiologically related. Blood culture isolates were initially misidentified because of variable Gram stain results, which led to misdiagnoses and subsequent laboratory exposures. Notifying laboratory personnel who unknowingly processed cultures from brucellosis patients is an important preventive measure. PMID:15504276

Noviello, Stephanie; Gallo, Richard; Kelly, Molly; Limberger, Ronald J; DeAngelis, Karen; Cain, Louise; Wallace, Barbara; Dumas, Nellie

2004-10-01

389

Ectopic cervical thymoma in a patient with Myasthenia gravis  

PubMed Central

Ectopic cervical thymoma is rare and is often misdiagnosed as a thyroid tumor or other malignancy. Ectopic thymic tissue can be found along the entire thymic descent path during embryogenesis. However, a thymoma arising from such ectopic thymic tissue is extremely rare. Herein we report a patient with ectopic cervical thymoma and myasthenia gravis (MG) and discuss the management.

2011-01-01

390

Spirit Possession and Exorcism in the Treatment of a Bedouin Psychiatric Patient  

Microsoft Academic Search

A male Bedouin psychiatric patient was initially misdiagnosed and treated as a paranoid schizophrenic. The modern mental health care system correctly understood the “form” of the patient's symptoms, auditory and visual hallucinations. It did not however at first appreciate their “content”, or cultural significance. The patient had unresolved anger toward his family which was manifested in an angry exchange with

Alean Al-Krenawi; John R. Graham

1997-01-01

391

The quiet epidemic.  

PubMed

More than half of patients treated in hospitals may suffer from depression or some other mental disorder that affects their health care. Misdiagnoses, wrong treatments, payment issues and a stigma about mental disorders that persists among the public, insurers and patients even in this enlightened era affect health care in ways we might not even realize. PMID:15597696

Bilchik, Gloria Shur

2004-11-01

392

CARBON MONOXIDE POISONING--A PUBLIC HEALTH PERSPECTIVE.  

EPA Science Inventory

Carbon monoxide (CO) may be the cause of more than one-half of the fatal poisonings reported in many countries: fatal cases also are grossly under-reported or mis-diagnosed by medical professionals. Therefore, the precise number of individuals who have suffered from CO intoxicat...

393

Brief Education About Autism Spectrum Disorders for Family Therapists  

Microsoft Academic Search

The prevalence of autism spectrum disorders (ASDs) is on the rise, and family therapists are increasingly likely to encounter clients who have some form of this disorder. There is emerging evidence that professionals, including family therapists, may misdiagnose the condition or that proper diagnosis and treatment may be delayed. Thus, professional education about ASDs is important. In addition to the

Kay Bradford

2010-01-01

394

Differentiation of Parkinson’s disease and multiple system atrophy in early disease stages by means of I-123-MIBG–SPECT  

Microsoft Academic Search

Background: Differential diagnosis between idiopathic Parkinson’s disease (PD) and multiple system atrophy (MSA) is often difficult in early disease stages. Since MSA is misdiagnosed as PD in more than 20% of the early stages, there is need for methods refining the differentiation of the two disease entities. In PD postganglionic involvement of the autonomic nervous system (ANS) predominates whereas in

A Druschky; M. J Hilz; G Platsch; M Radespiel-Tröger; K Druschky; T Kuwert; B Neundörfer

2000-01-01

395

A new minimally invasive technique for the repair of femoral hernia in children  

Microsoft Academic Search

BackgroundFemoral hernias in children are rare and often misdiagnosed. The classic treatment is through an open anterior approach. Since the advent of laparoscopic treatment of inguinal hernia in children, laparoscopy has been proposed to offer an accurate diagnosis and treatment, especially in case of recurrent hernia or bilateral disease. This review was undertaken to report our experience with the primary

Lucas E. M. Matthyssens; Paul Philippe

2009-01-01

396

Clinical Characteristics and Treatment Responses in Cases Diagnosed as Reactive Attachment Disorder  

Microsoft Academic Search

The aim of our study is to report the relation between pathological care and impairment in social interaction, communication, language development, and stereotypical behaviors. Fifteen cases (9 boys, 6 girls) who have the symptoms listed above and who were misdiagnosed with pervasive developmental disorder (PDD), were referred to our clinic for evaluation and treatment. After the cases were evaluated by

Nahit Motavalli Mukaddes; Sumru Bilge; Behiye Alyanak; Meltem Eröcal Kora

2000-01-01

397

Male Anorexia Nervosa: A New Focus.  

ERIC Educational Resources Information Center

Although anorexia nervosa affects over one million males yearly, it is often misdiagnosed or overlooked by mental health and medical practitioners. This article brings the problem to the forefront and outlines features that are unique to these males. Greater recognition of the disorder can lead to more accurate diagnoses and, subsequently, better…

Crosscope-Happel, Cindy; Hutchins, David E.; Getz, Hildy G.; Hayes, Gerald L.

2000-01-01

398

Scurvy: historical review and current diagnostic approach  

Microsoft Academic Search

Scurvy, a deficiency of vitamin C, now most often occurs in disadvantaged groups seen frequently in EDs: alcoholics with poor nutrition, the isolated elderly, and the institutionalized. Its prominent clinical features are lethargy; purpuric lesions, especially affecting the legs; myalgia; and, in advancing disease, bleeding from the gums with little provocation. Common misdiagnoses are vasculitis, blood dyscrasias, and ulcerative gingivitis.

Laura Pimentel

2003-01-01

399

Clinical characteristics of emergency department heart failure patients initially diagnosed as non-heart failure  

Microsoft Academic Search

BACKGROUND: Since previous studies suggest the emergency department (ED) misdiagnosis rate of heart failure is 10–20% we sought to describe the characteristics of ED patients misdiagnosed as non-decompensated heart failure in the ED. METHODS: We analyzed a prospective convenience sample of 439 patients at 4 emergency departments who presented with signs or symptoms of decompensated heart failure. Patients with a

Sean P Collins; Christopher J Lindsell; W Frank Peacock; Daniel C Eckert; Jeff Askew; Alan B Storrow

2006-01-01

400

Primary Cardiac Lymphoma: Helical CT Findings and Radiopathologic Correlation  

SciTech Connect

Primary tumors of the heart are extremely rare.Clinical manifestations are nondiagnostic and the patients are often misdiagnosed. Magnetic resonance imaging and echocardiography are standard in this diagnostic workup. We report a case of a man with acromegaly, dysphagia, chest pain and weight loss. An invasive cardiac mass was diagnosed by helical-CT. Autopsy demonstrated a B-cell aggressive lymphoma.

Marco de Lucas, Enrique, E-mail: radmle@humv.es; Pagola, Miguel Angel [HospitalUniversitario Marques de Valdecilla, Santander, Department of Radiology (Spain); Fernandez, Fidel [Hospital Universitario Marques de Valdecilla, Santander, Department ofPathology (Spain); Lastra, Pedro; Delgado, M. Luisa Ruiz; Sadaba, Pablo [HospitalUniversitario Marques de Valdecilla, Santander, Department of Radiology (Spain); Pinto, Jesus [Hospital Universitario Marques de Valdecilla, Santander, Department ofPathology (Spain); Ballesteros, Ma Angeles [Hospital Universitario Marques de Valdecilla, Santander, Department of Intensive Care Medicine (Spain); Ortiz, Antonio [HospitalUniversitario Marques de Valdecilla, Santander, Department of Radiology (Spain)

2004-03-15

401

Respiratory dyskinesia--an under-recognized side-effect of neuroleptic medications  

Microsoft Academic Search

Respiratory dyskinesia is an under-recognized side effect of neuroleptic administration. There are only few studies that have addressed the prevalence of respiratory dyskinesia in patients with tardive dyskinesia. Our case report highlights the need to regularly examine patients on antipsychotics for any evidence of dyskinetic movements including respiratory musculature. Since RD is underrecognized and misdiagnosed, early detection can improve long

Mukesh Mohan Bhimanil

2011-01-01

402

Development of an engineered ‘bioluminescent’ reporter phage for the detection of bacterial blight of crucifers  

Technology Transfer Automated Retrieval System (TEKTRAN)

Bacterial blight, caused by the phytopathogen Pseudomonas cannabina pv. alisalensis, is an emerging disease afflicting important members of the Brassica family. The disease is often misdiagnosed as peppery leaf spot, a much less severe disease caused by the closely related pathogen Pseudomonas syrin...

403

Managing the Clinical Consequences of Psychiatric Illness and Antipsychotic Treatment: A Discussion of Obesity, Diabetes, and Hyperprolactinemia  

Microsoft Academic Search

Many individuals who suffer from serious and persistent mental illness also have co-occurring physical problems that are frequently misdiagnosed, underdiagnosed, or undertreated. Tragically, this population loses between 8 and 20 years of life expectancy when compared to a nonpsychiatric population. Hyperglycemia, diabetes, and weight gain have long been established as correlating with mental illness and psychotropic medications, leaving it difficult

Betty Vreeland; Edward Kim

2004-01-01

404

Iatrogenic tracheal stenosis presenting as persistent asthma.  

PubMed

Although the incidence of post-intubation tracheal stenosis has markedly decreased with the advent of large volume, low pressure endotracheal tube cuffs, it still occurs, commonly in patients after prolonged intubation. We report a case of tracheal stenosis that developed after a brief period of endotracheal intubation, and that was misdiagnosed and treated as asthma and panic attacks. PMID:23345469

Barreiro, Timothy J; Ghattas, Christian; Ann Valino, Cherry

2013-01-23

405

Immigration, culture, and mental health: The story of a Honduran immigrant  

Microsoft Academic Search

Latinos are the largest minority in the U.S. and are projected to grow substantially. As a group their mental health needs are poorly addressed due to culturally biased assessments, culturally inappropriate interventions, lack of insurance, discrimination, poverty, and inadequate access to services. Moreover, a confluence of barriers in language, symptom expression, and culture results in elevated rates of misdiagnoses. Immigration

Antoine Bailliard

2008-01-01

406

Full Body Gait Analysis May Improve Diagnostic Discrimination Between Hereditary Spastic Paraplegia and Spastic Diplegia: A Preliminary Study  

ERIC Educational Resources Information Center

|Hereditary spastic paraplegia (HSP) and spastic diplegia (SD) patients share a strong clinical resemblance. Thus, HSP patients are frequently misdiagnosed with a mild form of SD. Clinical gait analysis (CGA) has been highlighted as a possible tool to support the differential diagnosis of HSP and SD. Previous analysis has focused on the lower-body…

Bonnefoy-Mazure, A.; Turcot, K.; Kaelin, A.; De Coulon, G.; Armand, S.

2013-01-01

407

Gliomatosis cerebri presenting as idiopathic intracranial hypertension in a child.  

PubMed

We present a rare case of a diffuse anaplastic astrocytoma (gliomatosis configuration) in a child, which was misdiagnosed as pseudotumor cerebri following initially normal CT of the brain and elevated opening pressure on lumbar puncture with normal cerebrospinal composition. PMID:21566531

Zunz, Eran; Ben Sira, Liat; Constantini, Shlomi; Fattal-Valevski, Aviva; Yalon, Michal; Roth, Jonathan; Cagnano, Emanuela; Kesler, Anat

2011-12-01

408

Assessment of obsessive–compulsive disorder: A review  

Microsoft Academic Search

Obsessive–compulsive disorder (OCD) affects approximately 2–3% of the adult population and is considered a debilitating and costly disorder, with associated impairments spanning the social, occupational, and familial domains. Although effective treatments of OCD exist, many individuals who suffer from OCD go undiagnosed or misdiagnosed, preventing them from obtaining appropriate treatment. As a result, making improvements to the assessment and diagnosis

Kristen Grabill; Lisa Merlo; Danny Duke; Kelli-Lee Harford; Mary L. Keeley; Gary R. Geffken; Eric A. Storch

2008-01-01

409

First Symptoms – Frontotemporal Dementia versus Alzheimer’s Disease  

Microsoft Academic Search

Frontotemporal dementia (FTD) is often misdiagnosed as Alzheimer’s disease (AD). We hypothesized that the first symptoms associated with FTD would be different from those seen in AD and that the first symptoms in FTD would reflect loss of function in the frontal region with the greatest degree of degeneration. The objective of the study was to compare the earliest symptoms

M. Lindau; O. Almkvist; J. Kushi; K. Boone; S. E. Johansson; L. O. Wahlund; J. L. Cummings; B. L. Miller

2000-01-01

410

Coincidence of paroxysmal supraventricular tachycardia and panic disorder: two case reports  

Microsoft Academic Search

Panic disorder (PD) is characterised by sudden attacks of intense fear with somatic symptoms including palpitations and tachycardia. Reciprocally, palpitations caused by paroxysmal supraventricular tachycardia (PSVT) are commonly associated with anxiety and may therefore be misdiagnosed as PD. As demonstrated by two case reports, PSVT and PD can occur comorbidly in a chronological sequence, with PSVT possibly precipitating and maintaining

Katharina Domschke; Paulus Kirchhof; Peter Zwanzger; Alexander L Gerlach; Günter Breithardt; Jürgen Deckert

2010-01-01

411

Migraine et céphalées de l’enfant et de l’adolescent  

Microsoft Academic Search

In childhood and adolescence, migraine is the main primary headache. This diagnosis is extensively underestimated and misdiagnosed in pediatric population. Lacks of specific biologic marker, specific investigation or brain imaging reduce these clinical entities too often to a psychological illness. Migraine is a severe headache evolving by stereotyped crises associated with marked digestive symptoms (nausea and vomiting); throbbing pain, sensitivity

D. Annequin; B. Tourniaire

2005-01-01

412

La migraine, pathologie méconnue chez l'enfant  

Microsoft Academic Search

Although migraine is the main chronic headache in childhood and adolescence, it remains extensively misdiagnosed. Schematically, migraine is a severe headache evolving by stereotyped attacks frequently associated with marked digestive symptoms (nausea, vomiting, abdominal pain). Throbbing pain, sensitivity to sound, and light (and sometimes odors) are frequent additional symptoms. The attack is sometimes preceded by a visual or sensory aura.

D Annequin; B Tourniaire; C Dumas

2000-01-01

413

Chlorine Dioxide Induced Multiple Chemical Sensitivity: MMPI Validity Problems.  

ERIC Educational Resources Information Center

|This paper discusses Minnesota Multiphasic Personality Inventory (MMPI) data obtained from individuals exposed to chlorine dioxide in the workplace who developed Multiple Chemical Sensitivity Syndrome. The paper explores current research on chlorine dioxide exposed persons who were misdiagnosed on the basis of MMPI interpretations. Difficulties…

Tentoni, Stuart C.

414

Tracking a Medically Important Spider: Climate Change, Ecological Niche Modeling, and the Brown Recluse (Loxosceles reclusa)  

Microsoft Academic Search

Most spiders use venom to paralyze their prey and are commonly feared for their potential to cause injury to humans. In North America, one species in particular, Loxosceles reclusa (brown recluse spider, Sicariidae), causes the majority of necrotic wounds induced by the Araneae. However, its distributional limitations are poorly understood and, as a result, medical professionals routinely misdiagnose brown recluse

Erin E. Saupe; Monica Papes; Paul A. Selden; Richard S. Vetter; Corrie Moreau

2011-01-01

415

Lung Cancer Diseases Diagnostic Asistance Using Gray Color Analysis  

Microsoft Academic Search

Errors in diagnosing the disease is a critical risk that must be faced by any person giving treatment to the hospital. Medical treatment can not always be done with perfect accuracy. Lung cancer is one of the most deadly disease that prone to misdiagnose. In general, some practitioners tend to “read” cancer in x-ray rontgen image as tumor this could

P. Paulus; F. L. Gaol

2010-01-01

416

Testing and Evaluative Procedures in Perspective. In Memoriam.  

ERIC Educational Resources Information Center

|A teacher recounts the case of a creative child who was misdiagnosed as brain damaged and endured failure because of a rigid system that did not allow him to demonstrate his insights and critical thinking. The boy eventually took his own life. (CL)|

Weiler, Barbara

1981-01-01

417

Kimura's disease: a diagnostic and therapeutic challenge  

Microsoft Academic Search

Introduction: Kimura's disease (KD) is a rare, benign, chronic inflammatory disease with unknown aetiology. Its manifestation is protean. KD has a predilection for the head and neck area, and typically presents as tumour-like lesions that could be easily misdiagnosed. We review our experience with four recent cases. Methods: Over a four-year period, all patients admitted to Singapore General Hospital with

H W Yuen; W K Low; S K Lim-Tan

418

Fever with rash in patients returning from popular tourist resort Phuket, Thailand: dengue--or measles?  

PubMed

We report three recent cases of measles in travelers to a popular vacation resort, Phuket, Thailand, two initially diagnosed clinically as dengue, one as drug reaction. In countries with no indigenous measles, clinicians may no longer recognize the disease. When left misdiagnosed, the patients continue to be potential transmitters. PMID:22943274

Kantele, Anu; Mattila, Leena; Ott, Kristi; Davidkin, Irja; Siikamäki, Heli

2012-08-08

419

Automated detection of intracranial aneurysms based on parent vessel 3D analysis  

Microsoft Academic Search

The detection of brain aneurysms plays a key role in reducing the incidence of intracranial subarachnoid hemorrhage (SAH) which carries a high rate of morbidity and mortality. The majority of non-traumatic SAH cases is caused by ruptured intracranial aneurysms and accurate detection can decrease a significant proportion of misdiagnosed cases. A scheme for automated detection of intracranial aneurysms is proposed

Alexandra Lauric; Eric Miller; Sarah Frisken; Adel M. Malek

2010-01-01

420

The Impact of Maternal Depressive Symptomatology on Ratings of Children with ADHD and Child Confederates  

Microsoft Academic Search

ome researchers who have studied children with behavior problems have suggested that depressed mothers distort reports of deviance in their children, perhaps contributing to misdiagnoses; howSever, investigations studying mothers with current or past depression have not clearly indicated such a bias. Because some of this equivocation may be due to the confounding effects of the mother—child history, the present study

Barbara L. Baumann; William E. Pelham; Alan R. Lang; Rolf G. Jacob; Jonathan D. Blumenthal

2004-01-01

421

Computer vision and digital imaging technology in melanoma detection  

Microsoft Academic Search

With today's treatment options, melanoma cure rates can be improved only if the diagnosis is made early enough to allow for curative surgery. Since clinical signs of malignancy in a pigmented lesion are often ambiguous and even dermatology experts may misdiagnose melanoma, diagnostic tools and procedures have been developed to assist the clinician in the diagnostic workup. Epiluminescence microscopy or

Holger Voigt; Richarda Classen

2002-01-01

422

Anatomy of pudendal nerve at urogenital diaphragm—new critical site for nerve entrapment  

Microsoft Academic Search

ObjectivesTo investigate the relations of the pudendal nerve in this complex anatomic region and determine possible entrapment sites that are accessible for surgical decompression. Entrapment neuropathies of the pudendal nerve are an uncommon and, therefore, often overlooked or misdiagnosed clinical entity. The detailed relations of this nerve as it exits the pelvis through the urogenital diaphragm and enters the mobile

Stephan Hruby; Johannes Ebmer; A. Lee Dellon; Oskar C. Aszmann

2005-01-01

423

Multiple cystic pulmonary hamartomas.  

PubMed Central

A patient with multiple cystic hamartomas presented with a pneumothorax and later developed a cystic myxomatous vaginal polyp. This and three of the cysts were resected. She remains well 13 years later. Multiple cystic hamartomas are uncommon and may be misdiagnosed as pulmonary metastases. Images

Mushtaq, M; Ward, S P; Hutchison, J T; Mann, J S

1992-01-01

424

Multiple cystic pulmonary hamartomas.  

PubMed

A patient with multiple cystic hamartomas presented with a pneumothorax and later developed a cystic myxomatous vaginal polyp. This and three of the cysts were resected. She remains well 13 years later. Multiple cystic hamartomas are uncommon and may be misdiagnosed as pulmonary metastases. PMID:1494774

Mushtaq, M; Ward, S P; Hutchison, J T; Mann, J S

1992-12-01

425

Living with the Active Alert Child: Groundbreaking Strategies for Parents. Third Edition.  

ERIC Educational Resources Information Center

|Bright, controlling, fearful, and highly energetic, active alert children are frequently misdiagnosed as hyperactive or learning disabled. This book offers guidance for the special challenge of parenting the active alert infant, child, and adolescent. Part 1 of the book profiles the active alert child and examines 11 traits that characterize…

Budd, Linda S.

426

Limb-shaking transient ischemic attacks: case report and review of literature  

Microsoft Academic Search

BACKGROUND: Limb shaking Transient Ischemic Attack is a rare manifestation of carotid-occlusive disease. The symptoms usually point towards a seizure like activity and misdiagnosed as focal seizures. On careful history the rhythmic seizure like activity reveals no Jacksonian march mainly precipitated by maneuvers which lead to carotid compression. We here present a case of an elderly gentleman who was initially

Saad Ali; Muhib Alam Khan; Bhojo Khealani

2006-01-01

427

Prevalence of Fissured Tongue, Geographic Tongue and Median Rhomboid Glossitis among Israeli Adults of Different Ethnic Origins  

Microsoft Academic Search

Background: Fissured tongue (FT), geographic tongue (GT) and median rhomboid glossitis (MRG) are frequently misdiagnosed and overtreated. FT is a relatively common variant of the tongue that includes numerous grooves or fissures on the dorsum of the tongue, while GT usually appears as areas of atrophy and raised white borders. MRG is an erythematous patch of atrophic papillae located in

Noam Yarom; Uri Cantony; Meir Gorsky

2004-01-01

428

Brucella Melitensis'in Neden Oldu?u Brusella Endokarditi  

Microsoft Academic Search

SUMMARY Brucellosis is a zoonotic disease endemically seen in Turkey, which occurs with various clinical findings. It can lead to complications affecting many systems. Endocarditis is an infrequent, but serious complication of brucellosis. The aim of this case presentation is to remind that endocarditis can be a complication of brucellosis and if is undiagnosed or misdiagnosed, progresses fatal in a

Suzan Saçar; Derya Hirçin Cenger; Semra Toprak Kavas; Ali Asan; Melek Demir; Mustafa Saçar; Hüseyin Turgut

429

[Puerperal uterine inversion: about two cases].  

PubMed

Two cases of third- and second-degree acute puerperal uterine inversions that required surgical management after manual attempts failed are reported. The diagnosis was obvious in the first case but the second inversion was misdiagnosed as a myoma, which led to severe morbidity, linked with the hemorrhage. PMID:15123120

Jerbi, M; Iraqui, Y; Jacob, D; Truc, J-B

2004-03-01

430

Head and neck intramuscular haemangioma: Report of two cases with unusual localization  

Microsoft Academic Search

Head and neck intramuscular haemangioma (IMH) is a benign, uncommon neoplasm arising most frequently in the masseter and trapezius muscles. It usually appears as an enlarging mass without specific clinical features and is therefore frequently misdiagnosed. We report two cases of IMH at unusual localizations: one involving the pterygoid muscles in a 30-year-old female and another one originating from the

Marco Giudice; Cesare Piazza; Andrea Bolzoni; Giorgio Peretti

2003-01-01

431

The Increase of Bipolar Disorder in Children and Adolescents  

Microsoft Academic Search

This cluster study investigates the different possibilities that may have caused an increase in the diagnosis of Bipolar Disorder in children and adolescents, including comparison to diagnosis in other countries. The same criteria for diagnosis of Bipolar Disorder for adults are used for children and adolescents, which may be misdiagnosed due to other disorders having the same characteristics, such as

Kristen Wroblewski

2008-01-01

432

Rupture of the right hemidiaphragm due to blunt trauma  

Microsoft Academic Search

Five cases of right-sided rupture of the diaphragm are reviewed. Orthopedic injury, head injury, and shock were the most common associated findings. Apparent elevation of the right hemidiaphragm was seen initially in all cases, but two were misdiagnosed. An algorithm that includes modified peritoneal lavage, CT scan with contrast, and intraperitoneal Tc sulfur colloid is suggested for patients with suspected

P LEAMAN

1983-01-01

433

Pyoderma gangrenosum: a misdiagnosis.  

PubMed

Pyoderma gangrenosum is an inflammatory disease of unknown etiology, commonly mistaken for an infection. Here, we report the case of a 55-year-old woman with an infectious process that was initially misdiagnosed as pyoderma gangrenosum and treated accordingly. We also discuss the criteria and the methods available to diagnose infections and pyoderma gangrenosum correctly. PMID:23377399

El-Kehdy, Jessica; Haneke, Eckart; Karam, Paula G

2013-02-01

434

Identifying Functional Neuroimaging Biomarkers of Bipolar Disorder: Toward DSM-V  

Microsoft Academic Search

Bipolar disorder is one of the most debilitating and com- mon illnesses worldwide. Individuals with bipolar disorder frequently present to clinical services when depressed but are often misdiagnosed with unipolar depression, leading to inadequate treatment and poor outcome. Increased ac- curacy in diagnosing bipolar disorder, especially during depression, is therefore a key long-term goal to improve the mental health of

Mary L. Phillips; Eduard Vieta

2007-01-01

435

VISUAL THERAPY: HELPING LEARNERS WHO HAVE TROUBLE LEARNING  

Microsoft Academic Search

Children who struggle to learn to read and write suffer embarrassment and pain; their parents are often frustrated, confused, and angry with their children, as well as their children's teachers. If a learning problem is noticed, it can be often misdiagnosed and\\/or the symptoms may be treated instead of the cause - when no improvement is then observed after remediation,

Robin Evers

436

Chlorine Dioxide Induced Multiple Chemical Sensitivity: MMPI Validity Problems.  

ERIC Educational Resources Information Center

This paper discusses Minnesota Multiphasic Personality Inventory (MMPI) data obtained from individuals exposed to chlorine dioxide in the workplace who developed Multiple Chemical Sensitivity Syndrome. The paper explores current research on chlorine dioxide exposed persons who were misdiagnosed on the basis of MMPI interpretations. Difficulties…

Tentoni, Stuart C.

437

COMPARACIÓN ENTRE ELECTROPUNTURA Y COMPRESIÓN ISQUÉMICA LOCAL EN EL  

Microsoft Academic Search

Comparison between electropuncture and local ischaemic compression in the myofascial pain syndrome. The myofascial pain syndrome represents a frequent pathology and a medical problem, generally misdiagnosed. The main symptom is musculoskeletal pain leading to functional incapacity. The objective was to compare the degree of pain relief and the amplitude of neck lateral movement by means of either electropuncture or local

Pedro José Salinas; Rosa Cho Cheng; Yolanda Monzón de Briceño

438

Oral and maxillofacial surgery in patients with chronic orofacial pain  

Microsoft Academic Search

Purpose: In this investigation, we evaluated a population of patients with chronic orofacial pain who sought treatment at a pain center in an academic institution. These patients were evaluated with respect to 1) the frequency and types of previous oral and maxillofacial surgery procedures, 2) the frequency of previous significant misdiagnoses, and 3) the number of patients who subsequently required

Howard A. Israel; John Desmond Ward; Brenda Horrell; Steven J. Scrivani

2003-01-01

439

Anisakiasis and gastroallergic reactions associated with Anisakis pegreffii infection, Italy.  

PubMed

Human cases of gastric anisakiasis caused by the zoonotic parasite Anisakis pegreffii are increasing in Italy. The disease is caused by ingestion of larval nematodes in lightly cooked or raw seafood. Because symptoms are vague and serodiagnosis is difficult, the disease is often misdiagnosed and cases are understimated. PMID:23621984

Mattiucci, Simonetta; Fazii, Paolo; De Rosa, Alba; Paoletti, Michela; Megna, Angelo Salomone; Glielmo, Antonio; De Angelis, Maurizio; Costa, Antonella; Meucci, Costantino; Calvaruso, Vito; Sorrentini, Italo; Palma, Giuseppe; Bruschi, Fabrizio; Nascetti, Giuseppe

2013-03-01

440

Sanctuary or Sanction?  

ERIC Educational Resources Information Center

A Harvard study suggests that minority students are often misdiagnosed as mentally retarded or behaviorally disabled; African-Americans are overrepresented in special-education classes and trail whites in achievement. Students are frequently placed in separate classes or schools. Predictable classroom routines can help kids with behavior problems.…

Newsom, John

2001-01-01

441

AKUTNI RETROVIRUSNI SINDROM PRI SLOVENSKIH BOLNIKIH, OKUŽENIH Z VIRUSOM HIV ACUTE RETROVIRAL SYNDROME IN SLOVENIAN PATIENTS INFECTED WITH HIV  

Microsoft Academic Search

Background. Two to six weeks after primary in- fection with HIV 50 to 90 percent of patients develop an acute retroviral syndrome which usually presents with mononucle- osis or flu-like illness. Due to nonspecific symptoms ARS is fre- quently misdiagnosed. Patients and methods. Data of Slovenian patients with acute retroviral syndrome is shown, as well as their symptoms, ap- proaches

Mario Poljak; Dunja Z. Babi?

442

[A woman with an abnormality of the palate].  

PubMed

A 75-year-old woman was seen at the ENT department because of a bleeding tumor on the hard palate. The abnormality mimicked both clinically and histopathologically a malignant salivary gland tumor, but after excision it was diagnosed as necrotizing sialometaplasia. Clinicians should be aware of this rare and easily misdiagnosed benign disease, in order to avoid unnecessary treatment. PMID:23965242

Rohof, D; van den Hoogen, F J A

2013-01-01

444

Validation of the World Health Organization (WHO) Criteria Using the Microscopic Agglutination Test (MAT) as the Gold Standard in the Diagnosis of Leptospirosis  

Microsoft Academic Search

Leptospirosis, with its varied manifestations, may mimic a large number of disease processes. It is frequently misdiagnosed as influenza, viral illness, pyrexia of unknown origin, aseptic meningitis, or viral hepatitis. This difficulty in diagnosis and the lack of community-based prevalence studies may have contributed to the fact that the disease is not widely recognized as a major health problem. It

D. G. Brato; M. T. Mendoza; C. P. Cordero; C. Ang; L. Dancel; B. Flor; S. Lim; V. Quilop; H. Santos; J. Tan; M. Tendencia; D. Yu

445

Estimates of variance components for genetic correlations among swine estrus traits.  

PubMed

Variance components and genetic correlations were estimated among estrus, puberty, growth, and composition traits in Landrace-Large White gilts (n = 1,225; Genetic Improvement Services, Newton Grove, NC) from 59 sires and 330 dams. Four groups of gilts entered the North Carolina Swine Evaluation Station in Clayton at an average age of 162 d and were checked daily for estrus. Once 70% of gilts had reached puberty, recording of estrus symptoms occurred every 12 h for 30 d, using fence-line boar contact. Subjective estrus traits were maximum strength of standing reflex with or without a boar present, total strength of standing reflex with or without a boar present, and strength of vulva reddening and swelling. Objective estrus traits consisted of vulva redness, vulva width, length of estrus in consecutive days based on 12-h observations, and age at puberty (AGEPUB). Growth and composition traits included puberty weight, days to 114 kg (DYS), 10th-rib backfat, and 10th-rib LM area at 114 kg (BF, LMA) and puberty. Variance components were estimated using AIREMLF90 with an animal model. All models included gilt development diet class and breed composition as fixed effects, entry age as a covariate (except DYS, BF, and LMA), a random common litter effect, and a random animal genetic effect. Heritability estimates for length of estrus, maximum strength of the standing reflex with a boar, total strength of the standing reflex with a boar, maximum strength of the standing reflex without a boar, total strength of the standing reflex without a boar, vulva redness, strength of vulva reddening and swelling, and vulva width were 0.21, 0.13, 0.26, 0.42, 0.42, 0.26, 0.45, and 0.58, respectively. Heritability estimates for AGEPUB, puberty weight, 10th-rib backfat at puberty, 10th-rib LM area at puberty, DYS, BF, and LMA were 0.29, 0.39, 0.41, 0.38, 0.24, 0.47, and 0.39, respectfully. Common litter effect estimates ranged from 0.01 to 0.09. The estimated genetic correlation between length of estrus and maximum strength of standing reflex with a boar was 0.99. Genetic correlations between AGEPUB and length of estrus, maximum strength of standing reflex with a boar, and vulva redness were -0.23, -0.32, and 0.20, respectively. Length of estrus had positive genetic associations with DYS and BF (0.30 and 0.29, respectively). It was concluded that past selection for lean BW gain may have weakened the strength of the standing reflex and that sufficient genetic variation exists to make selection for improved swine estrus traits effective. PMID:20525928

Knauer, M T; Cassady, J P; Newcom, D W; See, M T

2010-06-04

446

Cutaneous Gnathostomiasis with Recurrent Migratory Nodule and Persistent Eosinophilia: a Case Report from China  

PubMed Central

The present study reports a human case of cutaneous gnathostomiasis with recurrent migratory nodule and persistent eosinophilia in China. A 52-year-old woman from Henan Province, central China, presented with recurrent migratory reddish swelling and subcutaneous nodule in the left upper arm and on the back for 3 months. Blood examination showed eosinophila (21.2%), and anti-sparganum antibodies were positive. Skin biopsy of the lesion and histopathological examinations revealed dermal infiltrates of eosinophils but did not show any parasites. Thus, the patient was first diagnosed as sparganosis; however, new migratory swellings occurred after treatment with praziquantel for 3 days. On further inquiring, she recalled having eaten undercooked eels and specific antibodies to the larvae of Gnathostoma spinigerum were detected. The patient was definitely diagnosed as cutaneous gnathostomiasis caused by Gnathostoma sp. and treated with albendazole (1,000 mg/day) for 15 days, and the subsequent papule and blister developed after the treatment. After 1 month, laboratory findings indicated a reduced eosinophil count (3.3%). At her final follow-up 18 months later, the patient had no further symptoms and anti-Gnathostoma antibodies became negative. Conclusively, the present study is the first report on a human case of cutaneous gnathostomiasis in Henan Province, China, based on the past history (eating undercooked eels), clinical manifestations (migratory subcutaneous nodule and persistent eosinophilia), and a serological finding (positive for specific anti-Gnathostoma antibodies).

Cui, Jing; Wang, Ye

2013-01-01

447

Cutaneous gnathostomiasis with recurrent migratory nodule and persistent eosinophilia: a case report from china.  

PubMed

The present study reports a human case of cutaneous gnathostomiasis with recurrent migratory nodule and persistent eosinophilia in China. A 52-year-old woman from Henan Province, central China, presented with recurrent migratory reddish swelling and subcutaneous nodule in the left upper arm and on the back for 3 months. Blood examination showed eosinophila (21.2%), and anti-sparganum antibodies were positive. Skin biopsy of the lesion and histopathological examinations revealed dermal infiltrates of eosinophils but did not show any parasites. Thus, the patient was first diagnosed as sparganosis; however, new migratory swellings occurred after treatment with praziquantel for 3 days. On further inquiring, she recalled having eaten undercooked eels and specific antibodies to the larvae of Gnathostoma spinigerum were detected. The patient was definitely diagnosed as cutaneous gnathostomiasis caused by Gnathostoma sp. and treated with albendazole (1,000 mg/day) for 15 days, and the subsequent papule and blister developed after the treatment. After 1 month, laboratory findings indicated a reduced eosinophil count (3.3%). At her final follow-up 18 months later, the patient had no further symptoms and anti-Gnathostoma antibodies became negative. Conclusively, the present study is the first report on a human case of cutaneous gnathostomiasis in Henan Province, China, based on the past history (eating undercooked eels), clinical manifestations (migratory subcutaneous nodule and persistent eosinophilia), and a serological finding (positive for specific anti-Gnathostoma antibodies). PMID:24039291

Cui, Jing; Wang, Ye; Wang, Zhong Quan

2013-08-30

448

A seroepidemiological survey for toxocariasis in apparently healthy residents in Gangwon-do, Korea  

PubMed Central

We investigated the sero-prevalence of toxocariasis among healthy Korean adults in 1999. A total of 314 sera from normal inhabitants in Whachon-gun, Gangwon-do, Korea was examined for specific antibody levels against excretory-secretory products of second stage larvae of Toxocara (TES). The presence of cross-reactions with other helminthiases such as cysticercosis, paragonimiasis, sparganosis or clonorchiasis was also checked by specific IgG ELISA. Sera showing positive reaction against TES were also tested by IgG immunoblot and by IgE ELISA. Out of 314 subjects, 16 was found to be positive by TES IgG ELISA and immunoblot, among whom 12 were also positive by TES IgE ELISA. Among the 16 seropositive samples, two sera showed positive reaction against Paragonimus and sparganum antigen, respectively. These results inferred that cross-reactions were negligible between toxocariasis and other helminthiases. Toxocariasis seroprevalence among Korean rural adults was detected to be approximately 5%.

Park, Hyun-Young; Lee, Soo-Ung; Kong, Yoon; Magnaval, Jean-Francois

2002-01-01

449

Serodiagnosis of Toxocariasis by ELISA Using Crude Antigen of Toxocara canis Larvae  

PubMed Central

Toxocariasis is a worldwide zoonosis caused by larvae of ascarid nematodes of dogs or cats, Toxocara canis or T. cati. Diagnosis of human toxocariasis currently relies on serology that uses T. canis excretory-secretory antigen to detect specific IgG antibodies by ELISA. We investigated the serodiagnostic efficacy of ELISA using crude antigen of T. canis larvae (TCLA). Serum specimens of 64 clinically confirmed toxocariasis, 115 healthy controls, and 119 other tissue-invading helminthiases were screened by ELISA using TCLA. The ELISA using TCLA showed 92.2% (59/64 patient samples) sensitivity and 86.6% (103/119) specificity. Its positive diagnostic predictivity was 78.7% and negative predictivity was 97.8%. No serum of healthy controls reacted but that of anisakiasis (45.5%), gnathostomiasis (19.2%), clonorchiasis (15.8%), sparganosis (11.1%), and cysticercosis (6.3%) cross-reacted. Immunoblot analysis on TCLA recognized antigenic proteins of 28- and 30-kDa bands in their dominant protein quantity and strong blotting reactivity. The present results indicate that the ELISA using our TCLA antigen is acceptable by the sensitivity and specificity for serodiagnosis of human toxocariasis. ELISA with TCLA is recommended to make differential diagnosis for patients with any sign of organ infiltration and eosinophilia.

Jin, Yan; Shen, Chenghua; Huh, Sun; Sohn, Woon-Mok; Choi, Min-Ho

2013-01-01

450

Serodiagnosis of Toxocariasis by ELISA Using Crude Antigen of Toxocara canis Larvae.  

PubMed

Toxocariasis is a worldwide zoonosis caused by larvae of ascarid nematodes of dogs or cats, Toxocara canis or T. cati. Diagnosis of human toxocariasis currently relies on serology that uses T. canis excretory-secretory antigen to detect specific IgG antibodies by ELISA. We investigated the serodiagnostic efficacy of ELISA using crude antigen of T. canis larvae (TCLA). Serum specimens of 64 clinically confirmed toxocariasis, 115 healthy controls, and 119 other tissue-invading helminthiases were screened by ELISA using TCLA. The ELISA using TCLA showed 92.2% (59/64 patient samples) sensitivity and 86.6% (103/119) specificity. Its positive diagnostic predictivity was 78.7% and negative predictivity was 97.8%. No serum of healthy controls reacted but that of anisakiasis (45.5%), gnathostomiasis (19.2%), clonorchiasis (15.8%), sparganosis (11.1%), and cysticercosis (6.3%) cross-reacted. Immunoblot analysis on TCLA recognized antigenic proteins of 28- and 30-kDa bands in their dominant protein quantity and strong blotting reactivity. The present results indicate that the ELISA using our TCLA antigen is acceptable by the sensitivity and specificity for serodiagnosis of human toxocariasis. ELISA with TCLA is recommended to make differential diagnosis for patients with any sign of organ infiltration and eosinophilia. PMID:24039286

Jin, Yan; Shen, Chenghua; Huh, Sun; Sohn, Woon-Mok; Choi, Min-Ho; Hong, Sung-Tae

2013-08-30

451

Cystatin Capture Enzyme-Linked Immunosorbent Assay for Serodiagnosis of Human Clonorchiasis and Profile of Captured Antigenic Protein of Clonorchis sinensis  

PubMed Central

Enzyme-linked immunosorbent assay (ELISA) with crude extracts of adult Clonorchis sinensis has been reported to have a high degree of sensitivity with a moderate degree of specificity for the serodiagnosis of clonorchiasis. The cystatin capture ELISA was investigated for its usefulness for the serodiagnosis of human clonorchiasis. Cystatin bound specifically to cysteine proteinases in crude extracts of adult C. sinensis worms, and its binding capacity was not hindered competitively by the other proteinase inhibitors tested. The cystatin capture ELISA for clonorchiasis showed a higher degree of specificity than the conventional ELISA, which produced some cross-reactivities to sera from patients with cysticercosis, sparganosis, and opisthorchiasis. Immunoglobulin G antibodies to C. sinensis cysteine proteinases were produced in experimental rabbits at week 3, and their levels increased rapidly and remained at a plateau after 8 weeks of infection. Of the proteins from the C. sinensis crude extract captured with cystatin, seven proteins were reactive with the serum from patients with clonorchiasis. The cystatin capture ELISA is indicated to be a sensitive and highly specific immunodiagnostic assay for serodiagnosis of human clonorchiasis.

Kim, Tae Yun; Kang, Shin-Yong; Park, Sun Hyo; Sukontason, Kom; Sukontason, Kabkaew; Hong, Sung-Jong

2001-01-01

452

Zoonotic helminths affecting the human eye  

PubMed Central

Nowaday, zoonoses are an important cause of human parasitic diseases worldwide and a major threat to the socio-economic development, mainly in developing countries. Importantly, zoonotic helminths that affect human eyes (HIE) may cause blindness with severe socio-economic consequences to human communities. These infections include nematodes, cestodes and trematodes, which may be transmitted by vectors (dirofilariasis, onchocerciasis, thelaziasis), food consumption (sparganosis, trichinellosis) and those acquired indirectly from the environment (ascariasis, echinococcosis, fascioliasis). Adult and/or larval stages of HIE may localize into human ocular tissues externally (i.e., lachrymal glands, eyelids, conjunctival sacs) or into the ocular globe (i.e., intravitreous retina, anterior and or posterior chamber) causing symptoms due to the parasitic localization in the eyes or to the immune reaction they elicit in the host. Unfortunately, data on HIE are scant and mostly limited to case reports from different countries. The biology and epidemiology of the most frequently reported HIE are discussed as well as clinical description of the diseases, diagnostic considerations and video clips on their presentation and surgical treatment. Homines amplius oculis, quam auribus credunt Seneca Ep 6,5 Men believe their eyes more than their ears

2011-01-01

453

Pathology of CNS parasitic infections.  

PubMed

Parasitic infections of the central nervous system (CNS) include two broad categories of infectious organisms: single-celled protozoa and multicellular metazoa. The protozoal infections include malaria, American trypanosomiasis, human African trypanosomiasis, toxoplasmosis, amebiasis, microsporidiasis, and leishmaniasis. The metazoal infections are grouped into flatworms, which include trematoda and cestoda, and roundworms or nematoda. Trematoda infections include schistosomiasis and paragonimiasis. Cestoda infections include cysticercosis, coenurosis, hydatidosis, and sparganosis. Nematoda infections include gnathostomiasis, angiostrongyliasis, toxocariasis, strongyloidiasis, filariasis, baylisascariasis, dracunculiasis, micronemiasis, and lagochilascariasis. The most common route of CNS invasion is through the blood. In some cases, the parasite invades the olfactory neuroepithelium in the nasal mucosa and penetrates the brain via the subarachnoid space or reaches the CNS through neural foramina of the skull base around the cranial nerves or vessels. The neuropathological changes vary greatly, depending on the type and size of the parasite, geographical strain variations in parasitic virulence, immune evasion by the parasite, and differences in host immune response. Congestion of the leptomeninges, cerebral edema, hemorrhage, thrombosis, vasculitis, necrosis, calcification, abscesses, meningeal and perivascular polymorphonuclear and mononuclear inflammatory infiltrate, microglial nodules, gliosis, granulomas, and fibrosis can be found affecting isolated or multiple regions of the CNS, or even diffusely spread. Some infections may be present as an expanding mass lesion. The parasites can be identified by conventional histology, immunohistochemistry, in situ hybridization, and PCR. PMID:23829901

Pittella, José Eymard Homem

2013-01-01

454

Tomotherapy - a different way of dose delivery in radiotherapy  

PubMed Central

Aim of the study Helical tomotherapy is one of the methods of radiotherapy. This method enables treatment implementation for a wide spectrum of clinical cases. The vast array of therapeutic uses of helical tomotherapy results directly from the method of dose delivery, which is significantly different from the classic method developed for conventional linear accelerators. The paper discusses the method of dose delivery by a tomotherapy machine. Moreover, an analysis and presentation of treatment plans was performed in order to show the therapeutic possibilities of the applied technology. Dose distributions were obtained for anaplastic medulloblastoma, multifocal metastases to brain, vulva cancer, tongue cancer, metastases to bones, and advanced skin cancer. Tomotherapy treatment plans were compared with conventional linear accelerator plans. Results Following the comparative analysis of tomotherapy and conventional linear accelerator plans, in each case we obtained the increase in dose distribution conformity manifested in greater homogeneity of doses in the radiation target area for anaplastic medulloblastoma, multifocal metastases to brain, vulva cancer, metastases to bones, and advanced skin cancer, and the reduction of doses in organs at risk (OAR) for anaplastic medulloblastoma, vulva cancer, tongue cancer, and advanced skin cancer. The time of treatment delivery in the case of a tomotherapy machine is comparable to the implementation of the plan prepared in intensity-modulated radiotherapy (IMRT) technique for a conventional linear accelerator. In the case of tomotherapy the application of a fractional dose was carried out in each case during one working period of the machine. For a conventional linear accelerator the total value of the fractional dose in the case of anaplastic medulloblastoma and metastases to bones was delivered using several treatment plans, for which a change of set-up was necessary during a fraction. Conclusion The obtained results confirm that tomotherapy offers the possibility to obtain precise treatment plans together with the simplification of the therapeutic system.

Skorska, Malgorzata; Jodda, Agata; Ryczkowski, Adam; Kazmierska, Joanna; Adamska, Krystyna; Karczewska-Dzionk, Aldona; Zmijewska-Tomczak, Malgorzata; Wlodarczyk, Hanna

2012-01-01

455

Description of Hemicaloosia graminis n. sp. (Nematoda: Caloosiidae) Associated with Turfgrasses in North and South Carolina, USA  

PubMed Central

A new nematode species was discovered during a diversity survey of plant-parasitic nematodes on turfgrass conducted in North and South Carolina in 2010 and 2011. It is described herein as Hemicaloosia graminis n. sp. and is characterized by two annuli in the lip region, one lateral line, body 610.0–805.0 ?m long, stylet 65.0–74.6 ?m long, vulva at 84.1% –85.8% of the body , 254–283 annuli, vulva at the 38–53rd annulus from tail terminus, 12–14 annuli between vulva and anus, tail elongate-pointed, 67.5–84.8 ?m long in females and spicule straight, 31.0 ?m long, caudal alae well developed, two lateral lines in males. The newly described species is morphologically closest to H. paradoxa, but has a longer stylet (65.0–74.6 vs 61.0–65.0 ?m) and a higher V-value (84.1–85.8 vs 78.1–84.0%), less RV (38–53 vs 50–56), higher RVan (12–14 vs 10) in females, and a shorter tail (30.1 vs 36.7 ?m) and more anteriorly located excretory pore (105.9 vs 140.0 ?m) in the male. It was easily differentiated from other species based on near-full-length small subunit rRNA gene (SSU) and ITS1 sequences. Phylogenetic analysis from SSU supports placement in a monophyletic clade with the genus Caloosia. An identification key and a table of distinguishing characteristics are presented for all seven species of Hemicaloosia.

Zeng, Yongsan; Ye, Weimin; Tredway, Lane; Martin, Samuel; Martin, Matt

2012-01-01

456

Comparative Morphology of Meloidodera spp. and Verutus sp. (Heteroderidae) with Scanning Electron Microscopy  

PubMed Central

Scanning electron microscopy (SEM) of second-stage juveniles (J2), males, and females of Meloidodera floridensis, M. charis, M. belli, and Verutus volvingentis reveals detailed characteristics of the head region, lateral field, phasmid, body striae, vulva, and perineal region. In M. charis and M. belli the en face pattern conforms to a basic pattern in which the labial disc is surrounded by six lips (sectors) of the first head annulation. In J2 the head has additional annulations, whereas in males annulation is replaced by longitudinal blocks. Conversely, J2 and males of M. floridensis and V. volvingentis each have a unique derived face pattern with fusion of various lip components and with head annulation. All six lips of females of M. charis and M. belli are fused, whereas females of M. floridensis and V. volvingentis have distinct lateral lips. Lateral fields vary among species, with only slight differences at the anterior and posterior ends of the lateral lines and in the spatial relation of the lines to phasmid openings. Phasmid openings are present in adults of Meloidodera spp., but were not observed in adults of V. volvingentis; in this respect, the female perineal pattern of Verutus is different from Meloidodera spp, The very large vulva (± 48 ?m long) of V. volvingentis is in sharp contrast to the minute vulva (± 6 ?m long) in a population of M. charis from San Bernardino. Morphological characters revealed by SEM will be most informative when investigated throughout Heteroderidae and incorporated with additional characters for a phylogenetic analysis of the family.

Othman, Abubaker A.; Baldwin, J. G.

1985-01-01

457

Comparative Morphology of Meloidodera spp. and Verutus sp. (Heteroderidae) with Scanning Electron Microscopy.  

PubMed

Scanning electron microscopy (SEM) of second-stage juveniles (J2), males, and females of Meloidodera floridensis, M. charis, M. belli, and Verutus volvingentis reveals detailed characteristics of the head region, lateral field, phasmid, body striae, vulva, and perineal region. In M. charis and M. belli the en face pattern conforms to a basic pattern in which the labial disc is surrounded by six lips (sectors) of the first head annulation. In J2 the head has additional annulations, whereas in males annulation is replaced by longitudinal blocks. Conversely, J2 and males of M. floridensis and V. volvingentis each have a unique derived face pattern with fusion of various lip components and with head annulation. All six lips of females of M. charis and M. belli are fused, whereas females of M. floridensis and V. volvingentis have distinct lateral lips. Lateral fields vary among species, with only slight differences at the anterior and posterior ends of the lateral lines and in the spatial relation of the lines to phasmid openings. Phasmid openings are present in adults of Meloidodera spp., but were not observed in adults of V. volvingentis; in this respect, the female perineal pattern of Verutus is different from Meloidodera spp, The very large vulva (+/- 48 mum long) of V. volvingentis is in sharp contrast to the minute vulva (+/- 6 mum long) in a population of M. charis from San Bernardino. Morphological characters revealed by SEM will be most informative when investigated throughout Heteroderidae and incorporated with additional characters for a phylogenetic analysis of the family. PMID:19294097

Othman, A A; Baldwin, J G

1985-07-01

458

Hystrignathus dearmasi sp. n. (Oxyurida, Hystrignathidae), first record of a nematode parasitizing a Panamanian Passalidae (Insecta, Coleoptera)  

PubMed Central

Abstract Hystrignathus dearmasi sp. n. (Oxyurida: Hystrignathidae) is described from an unidentified passalid beetle (Coleoptera: Passalidae) from Panama. It resembles Hystrignathus cobbi Travassos & Kloss, 1957 from Brazil, by having a similar form of the cephalic end, extension of cervical spines and absence of lateral alae. It differs from the latter species by having the body shorter, the oesophagus and tail comparatively larger, the vulva situated more posterior and the eggs ridged. This species constitutes the first record of a nematode parasitizing a Panamanian passalid.

Morffe, Jans; Garcia, Nayla

2010-01-01

459

Tumorigenic Role of Podoplanin in Esophageal Squamous-Cell Carcinoma  

Microsoft Academic Search

Background  Podoplanin, a mucin-type transmembrane glycoprotein, is thought to be one of the cancer stem cell markers for squamous-cell\\u000a carcinoma of the vulva. The objectives of the present study were to examine the role of podoplanin in esophageal squamous-cell\\u000a carcinoma (ESCC).\\u000a \\u000a \\u000a \\u000a \\u000a Methods  Expression of podoplanin was examined immunohistochemically in 61 cases of ESCC that had not been treated with chemotherapy\\u000a or radiotherapy

Nur Rahadiani; Jun-ichiro Ikeda; Tomoki Makino; Tian Tian; Ying Qiu; Suhana Mamat; Yi Wang; Yuichiro Doki; Katsuyuki Aozasa; Eiichi Morii

2010-01-01

460

Clinical effect of Kukkutanda Twak Bhasma in the management of Swetapradara  

PubMed Central

Swetapradara is an important gynecological disorder nowadays. Most women in the reproductive age group complain about white discharge. Due to white discharge, they are prone to so many other symptoms, such as backache, itching in vulva, and burning micturition. According to Ayurveda, swetapradara is caused by the vitiation of Kapha and Vata dosha. Kukkutanda twak is also said to be Kapha Vata shamaka and swetapradara shamaka. In Ayurveda so many drugs are mentioned in the treatment of swetapradara. Among them Kukkutanda twak bhasma is a good medicine. In this clinical study Kukkutanda twak bhasma has shown statistically significant improvement in white discharge, backache, itching, anemia, weakness, and urinary tract infection.

Panda, Gatikrushna; Mohapatra, K. B.

2011-01-01

461

Uterine endometrial polyp with severe hemorrhage and cystic endometrial hyperplasia-pyometra complex in a dog.  

PubMed

The current report describes an unusual presentation of uterine endometrial polyp with severe hemorrhage and cystic endometrial hyperplasia-pyometra complex in a 9.5-year-old female Doberman Pinscher. The dog presented with a 2-day history of bloody discharge from the vulva and an enlarged abdomen. The postmortem examination revealed a markedly distended right uterine horn with a large pedunculated mass (17 cm x 9 cm x 4 cm) and blood. Based on the histological findings, the diagnosis of uterine endometrial polyp was made. PMID:20453227

Gumber, Sanjeev; Springer, Nora; Wakamatsu, Nobuko

2010-05-01

462

[Lichen sclerosus--a neglected disease].  

PubMed

We present a small review of lichen sclerosus in women and an update on the newest knowledge, e.g. on calcineurin inhibitors as a choice of treatment. The goal is to put more focus on the disease in Denmark because it is so often diagnosed only with a great delay. We further emphasize the importance of follow-up on these patients, due to the risk of cancer, the great influence of the disease on quality of life and the risk of structural changes in the vulva region. PMID:22094215

Sander, Bente Braad; Damsgaard, Knud

2011-11-14

463

Case report: vulvar lichen sclerosus in a premenarchal girl with a complicated biopsy.  

PubMed

Lichen sclerosus is a T-lymphocyte mediated chronic cutaneous disorder with predilection for the vulva. In prepubertal girls, lichen sclerosus presents as vulvar discomfort, pruritus, bruising/bleeding, discharge, dysuria, or painful defecation. Diagnosis and treatment of lichen sclerosus is of utmost importance in the prevention of complications such as scarring, adhesions, atrophy, or long-term sexual dysfunction. We discuss a case of a 4-year-old female with an atypical presentation of genital lichen sclerosus and a complicated biopsy. PMID:19706110

Yousefi, Morvarid; Pride, Howard; Elston, Dirk

464

Clinical effect of Kukkutanda Twak Bhasma in the management of Swetapradara.  

PubMed

Swetapradara is an important gynecological disorder nowadays. Most women in the reproductive age group complain about white discharge. Due to white discharge, they are prone to so many other symptoms, such as backache, itching in vulva, and burning micturition. According to Ayurveda, swetapradara is caused by the vitiation of Kapha and Vata dosha. Kukkutanda twak is also said to be Kapha Vata shamaka and swetapradara shamaka. In Ayurveda so many drugs are mentioned in the treatment of swetapradara. Among them Kukkutanda twak bhasma is a good medicine. In this clinical study Kukkutanda twak bhasma has shown statistically significant improvement in white discharge, backache, itching, anemia, weakness, and urinary tract infection. PMID:22529653

Panda, Gatikrushna; Mohapatra, K B

2011-07-01

465

Successful treatment of Zoon's vulvitis with high potency topical steroid.  

PubMed

Zoon's vulvitis is a rare, chronic condition of the vulva that presents with burning, pruritus, and dysuria with characteristic lesions and histopathology. Several treatment options have been reported with limited success. A 63-year-old woman with Zoon's vulvitis diagnosed on histopathology was treated with clobetasol propionate 0.05%. Complete resolution of her symptoms and lesions occurred in less than 1 week. No recurrence of her symptoms has occurred after 9 months. Zoon's vulvitis may be successfully and expeditiously treated with high potency topical steroids. PMID:15834511

Botros, Sylvia M; Dieterich, Mark; Sand, Peter K; Goldberg, Roger P

2005-04-15

466

Extramammary Paget's disease masquerading as lichen sclerosus.  

PubMed

A wide range of genital infections and skin conditions may present with vulval pruritus. Lichen sclerosus is one cause. This is often associated with visible skin changes which include atrophy, resorption or fusion of the labia, sclerosis and excoriation. Ulceration may indicate malignant transformation and requires urgent biopsy. Many experienced clinicians diagnose lichen sclerosus on clinical appearance, however we recommend a low threshold for biopsy, especially for non-responding or odd looking lesions. We report a patient whose vulval skin biopsy for clinically suspected lichen sclerosus revealed extramammary Paget's disease of the vulva. We review the pathology, prognosis and treatment of this condition. PMID:15006079

Bansal, D; Bowman, C A

2004-02-01

467

Two unusual tumours in a ferret (Mustela putorius furo).  

PubMed

This case report describes the clinical history, diagnosis and treatment of a ferret with a tumour of the right adrenal gland and insulinomas of the pancreas. Histopathology of both lesions confirmed the diagnoses. Clinical signs of the adrenal gland tumour were a swollen vulva, overgrooming, sexual activity and pruritus. The clinical signs suggesting insulinomas were collapse of the ferret, disorientation and ptyalism. A low blood glucose level assisted the diagnosis of insulinomas. This is believed to be the first reported case of concurrent insulinomas and adrenal gland tumour in a ferret in the United Kingdom. PMID:15460204

Eatwell, K

2004-09-01

468

Vulvar lactating adenoma associated to a fibroadenoma: common neoplasms in an uncommon site  

PubMed Central

Ectopic breast tissue is defined as glands located outside of the breast. Ectopic breast tissue should be excised because it may develop benign (fibroadenoma) or malignant pathologic processes. Less than forty cases of fibroadenomas have been reported in the literature. Although lactation changes can occur, lactating adenoma in the vulva are extremely rare. Only four cases have been reported. We report a case of a young woman who presented with vulvar mass during her lactation. The mass was excised, and histology confirmed vulvar lactating adenoma associated with fibroadenoma. This is the first case of vulvar heterotopic breast lesion associating lactating adenoma and fibroadenoma.

Dhaoui, Amen; Nfoussi, Haifa; Kchir, Nidhameddine; Haouet, Slim

2012-01-01

469

Incidental idiopathic calcinosis cutis in a rhytidectomy patient.  

PubMed

Calcinosis cutis, deposition of insoluble calcium salts in cutaneous tissues, is an uncommon disorder. This condition can be classified as metastatic, dystrophic, idiopathic, and iatrogenic based on the pathogenesis of the deposition. Whereas dystrophic calcinosis cutis is a fairly common condition, idiopathic cases are very rare. Distinct cutaneous anatomic areas, the vulva, scrotum, penis, and breast, have been reported to develop this disorder. Nevertheless, our case who had idiopathic calcinosis cutis in her neck may be a proof that this condition is not confined to genitals or the breasts and can be seen all over the skin. PMID:15274707

Aksoy, Hasan Mete; Ozdemir, Ragip; Karaaslan, Onder; Tiftikcioglu, Yigit Ozer; Oruç, Melike; Koçer, Ugur

2004-08-01

470

Phenotypic and genetic correlations between gilt estrus, puberty, growth, composition, and structural conformation traits with first-litter reproductive measures.  

PubMed

The objective was to estimate correlations of gilt estrus, puberty, growth, composition, and structural conformation traits with first-litter reproductive measures. Four groups of gilts (n = 1,225; Genetic Improvement Services of NC, Newton Grove, NC) entered the NC Swine Evaluation Station (Clayton, NC) averaging 162 d of age and were observed daily for symptoms of estrus. Once symptoms of first estrus were observed in 70% of gilts, recording of symptoms of estrus in all gilts occurred every 12 h for 30 d, utilizing fence-line boar contact. Subjective estrous traits were maximum and total strength of standing reflex, as observed with and without the presence of a boar, and strength of vulva reddening and swelling. Objective estrous traits consisted of vulva redness, vulva width, length of estrus, and age at puberty. Growth and composition traits included BW at puberty, days to 114 kg, and 10th rib backfat and LM area at 114 kg and at puberty. Subjective structural conformation traits were muscle mass, rib width, front leg side view, rear leg side view, front legs front view, rear legs rear view, and locomotion. First-litter sow traits included if gilt farrowed (Stay), age at first farrowing (AFF), total number of piglets born (TNB), and weaning to conception interval (WCI). Variance components were estimated using an animal model with AIREMLF90 for linear traits and THRGIBBS1F90 for categorical traits. Heritability estimates for Stay, AFF, and TNB were 0.14, 0.22, and 0.02, respectively. Genetic correlations between length of estrus, the standing reflex traits, and age at puberty with Stay were 0.34, 0.34 to 0.74, and -0.27, respectively, and with AFF were -0.11, -0.04 to -0.41, and 0.76, respectively. Days to 114 kg had genetic associations with Stay, AFF, and TNB of 0.52, -0.25, and -0.08, respectively. Backfat at 114 kg had genetic correlations with Stay, AFF, and TNB of -0.29, 0.14, and 0.47, respectively. Vulva redness and TNB were negatively correlated phenotypically (r = -0.14) and genetically (r = -0.53). Associations between structural conformation traits with Stay, AFF, TNB, and WCI were generally low to moderate and favorable. Selection for longer length of estrus, stronger standing reflex, or younger age at puberty would increase the proportion of gilts that farrow and reduce age at first farrowing. PMID:21148777

Knauer, M T; Cassady, J P; Newcom, D W; See, M T

2010-12-10

471

Disseminated transmissible venereal tumour associated with Leishmaniasis in a dog.  

PubMed

This report addresses an atypical transmissible venereal tumour in an 8-year-old bitch that was pluriparous and seropositive for leishmaniasis. There were ascites and a serosanguineous discharge from the vulva, but no lesions on the external genital mucosa. An aspirate of the peritoneal fluid showed mononuclear round cells characteristic of transmissible venereal tumour (TVT). Exploratory laparotomy revealed light red, granulomatous structures in the peritoneum, omentum, spleen, liver and uterine horns. Cytological and histopathological tests confirmed the diagnosis of intra-abdominal TVT. Dissemination of the TVT to several organs inside the abdominal cavity probably resulted from immunosuppression caused by leishmaniasis, which favoured the presence and aggressiveness of TVT. PMID:23279537

Trevizan, J T; Carreira, J T; Souza, N C; Carvalho, I R; Gomes, P B C; Lima, V M F; Orlandi, C M B; Rozza, D B; Koivisto, M B

2012-12-01

472

`Normal' vaginal microbiology of women of childbearing age in relation to the use of oral contraceptives and vaginal tampons  

PubMed Central

The vaginal microbiology of women attending a family planning clinic was found to be unrelated to the use of oral contraceptives and vaginal tampons. Beta haemolytic streptococci isolated from this `normal' population were compared with those from 1,104 women attending general practitioners complaining of vaginal discharge. There is a caution regarding the indications for antibiotic therapy. Observations were made on the effects of contamination of vaginal swabs with yeasts and ?-haemolytic streptococci from the vulva. The persistent character of the vaginal flora over a six-month period is described.

Morris, C. A.; Morris, Delia F.

1967-01-01

473

Resection and Reconstruction of Maxillary Class IIIc Defect in a Case of Adenoid Cystic Carcinoma: Cost-Sensitive Technique without Microvascular Grafts  

PubMed Central

ACC is a rare malignant tumor that affects most commonly the major and minor salivary glands and rarely the paranasal sinuses, lacrimal gland, larynx, ear, vulva, and so forth. The maxillary sinus when affected is considered having a poor prognosis due to delayed diagnosis and delayed treatment credited to its slow spread, late symptoms, and complex anatomy which hampers surgical resection. The expressions of tumor markers too have a significant role in determining the prognosis. The treatment of choice consists of wide radical resection of the tumor followed by radiotherapy. Rehabilitation options in cases with huge maxillary defects still need further exploration.

Adwani, Dwarkadas; Arora, Rajender Singh; Soni, Ramawatar; Adwani, Nitin

2013-01-01

474

Pseudovascular adenoid squamous cell carcinoma of oral cavity: A mimicker of angiosarcoma  

PubMed Central

Pseudovascular adenoid squamous cell carcinoma (PASCC) is an uncommon histological variant of squamous cell carcinoma that can mimic vascular neoplasms, particularly angiosarcoma, in its morphologic characteristics. PASCC has been reported in the head and neck, as well as in the other organs such as the breast, lungs, urinary bladder, vulva, and uterine cervix. Only two cases of PASCC arising from the upper aerodigestive tract have been reported so far. We report a case of PASCC of oral cavity in a 40-year-old man, which mimicked an angiosarcoma initially. Immunohistochemical analysis led to a conclusive diagnosis of PASCC.

Vidyavathi, K; Prasad, CSBR; Kumar, Harendra ML; Deo, RP

2012-01-01

475

Description of a new Pratylenchus species from China (Tylenchida, Pratylenchidae).  

PubMed

Pratylenchus ekrami from maize (Zea mays) roots in Shenyang and luffa (Luffa cylindrica) roots in Dalian, China, are described in this paper. Nematodes from the two areas were identified consistently, and were characterized by a heavy cephalic sclerotization, extending posteriorly up to two body annuli, stylet 11-13 ?m long, elongating conoid tail, and becoming thinner from vulva. Males were not found. Pratylenchus ekrami is close to Pratylenchus vulnus, but the most critical characteristics between the two species were the number of lip annuli, stylet size, and shape of stylet knobs. This species is the first reported in China. PMID:24115672

Liu, Ning; Zhou, Xiao-Song; Chen, Li-Jie; Duan, Yu-Xi

2013-10-01

476

Tubulopapillary mammary carcinoma in a brown bear (Ursus arctos).  

PubMed

A 28-yr-old, nulliparous female brown bear (Ursus arctos) at the Karacabey Ovakurusu Bear Sanctuary presented with an enlargement of the mammary gland. Three other nodules were also noted in the proximity of the mammary gland and over the vulva. Clinical, hematologic, ultrasonographic, and radiologic examinations were performed; the enlarged mammary gland was removed and the other masses were also excised. Histopathologic examination revealed tubulopapillary carcinoma of the mammary gland, and the other masses were diagnosed as epidermoid cysts. This is the first reported case of tubulopapillary mammary carcinoma accompanied by epidermoid cysts in a bear. PMID:18436688

Nak, Deniz; Cangul, I Taci; Nak, Yavuz; Cihan, Huseyin; Celimli, Nureddin

2008-04-01

477

Susac syndrome. A differential diagnosis for demyelination.  

PubMed

Susac syndrome is a microangiopathy of unknown origin, probably autoimmune, affecting capillaries and precapillary arterioles of the brain, retina, and inner ear. It is often misdiagnosed as acute disseminated encephalomyelitis or multiple sclerosis. We report the case of a 25-year-old male with Susac syndrome who developed the clinical triad of encephalopathy, visual and hearing problems over the course of a year. The characteristic MRI findings including central corpus callosal involvement and brain infarctions were supported by branch retinal arterial/arteriolar occlusions on fluorescein retinal angiography. Most patients with Susac syndrome will not have the complete clinical triad initially. A very high index of suspicion is required by the clinician and radiologist in patients with any component of the clinical triad so as not to misdiagnose the MRI findings for demyelination. Even if initial ophthalmologic examinations are normal, these patients should be followed up for later development of branch retinal artery occlusions. PMID:23291802

Vattoth, Surjith; Compton, Christopher J; Roberson, Glenn H; Vaphiades, Michael S

2013-01-01

478

Exercise-induced vasculitis associated with autoimmune disease.  

PubMed

Exercised-induced vasculitis (EIV) is an underreported and frequently misdiagnosed condition that occurs on the lower extremities shortly after exercise. Most reported cases have presented in healthy-appearing individuals, but some cases have been linked to other disease processes. A case report is presented of recurring EIV in a 65-year-old woman with a history of dermatitis herpetiformis; chronic, mildly elevated liver transaminases of unknown cause; microscopic colitis; celiac disease; multiple miscarriages; and heart block who was found to have autoimmune hepatitis upon workup of her rash. Both EIV and autoimmune hepatitis were misdiagnosed over many years by several clinicians in various specialties. Her family history was remarkable for 2 sisters with systemic lupus erythematosus and similar recurring exercise-induced rashes of the lower extremities, suggesting a familial link for this condition. Clinicians should recognize EIV and consider the possibility that this disorder may be the presenting sign of subclinical connective-tissue diseases. PMID:19681343

Knoell, Keith Allen

2009-06-01

479

Late diagnosis of a rare disease.  

PubMed

Rare diseases may be misdiagnosed if laboratory investigations show a common diagnosis instead. This is the story of 24-year-old male patient misdiagnosed as a case of hereditary spherocytosis at the age of 10 years. He received regular blood transfusions. Thorough investigations revealed microcytic anaemia, with results for all hereditary and acquired causes of haemolytic anemia negative, iron overload in the liver, stunted growth, insulin-dependent diabetes mellitis, hypercellular bone marrow and marked depletion of its iron stores. The transferrin level was very low when repeatedly measured, making congenital atransferrinaemia the most acceptable diagnosis for this case with haemochromatosis. Congenital atransferrinaemia is a very rare disease, with few cases recorded worldwide. Most cases died at a young age if not treated properly. Our patient is still alive although only recently diagnosed. He is now undergoing treatment with plasma transfusion, iron-chelating therapy and antituberculous treatment for pulmonary and osteoarthritic tuberculosis. PMID:21686831

Hossainy, Noha Mohamed El

2009-04-14

480

Late diagnosis of a rare disease  

PubMed Central

Rare diseases may be misdiagnosed if laboratory investigations show a common diagnosis instead. This is the story of 24-year-old male patient misdiagnosed as a case of hereditary spherocytosis at the age of 10 years. He received regular blood transfusions. Thorough investigations revealed microcytic anaemia, with results for all hereditary and acquired causes of haemolytic anemia negative, iron overload in the liver, stunted growth, insulin-dependent diabetes mellitis, hypercellular bone marrow and marked depletion of its iron stores. The transferrin level was very low when repeatedly measured, making congenital atransferrinaemia the most acceptable diagnosis for this case with haemochromatosis. Congenital atransferrinaemia is a very rare disease, with few cases recorded worldwide. Most cases died at a young age if not treated properly. Our patient is still alive although only recently diagnosed. He is now undergoing treatment with plasma transfusion, iron-chelating therapy and antituberculous treatment for pulmonary and osteoarthritic tuberculosis.

Hossainy, Noha Mohamed El

2009-01-01

481

Oral carcinoma cuniculatum: two cases illustrative of a diagnostic challenge.  

PubMed

Carcinoma cuniculatum is a rare variant of squamous cell carcinoma originally described on the sole of the foot and for a long time believed to be restricted to the skin. However, since its first description in 1954, several cases have been reported at other sites. Carcinoma cuniculatum characteristically invades the underlying subcutaneous, submucosal, or bone tissues, forming so-called "rabbit burrows," with crypts filled with keratin that are of utmost importance for distinguishing this neoplasm from other variants of squamous cell carcinoma. Oral carcinoma cuniculatum is an even rarer entity that is frequently misdiagnosed initially, a phenomenon described in about one-third of previously reported cases. The aim of this report is: (1) to describe the clinicopathologic features of 2 new cases of oral carcinoma cuniculatum, initially misdiagnosed as infected orthokeratinized cyst and abscess, respectively; and (2) to review the related English language literature. PMID:24035112

Fonseca, Felipe Paiva; Pontes, Hélder Antônio Rebelo; Pontes, Flávia Sirotheau Corrêa; de Carvalho, Pedro Luiz; Sena-Filho, Marcondes; Jorge, Jacks; Santos-Silva, Alan Roger; de Almeida, Oslei Paes

2013-10-01

482

A case of an aortic dissection in a young adult: a refresher of the literature of this "great masquerader"  

PubMed Central

Aortic dissection is often misdiagnosed, especially among young patients, and it is associated with a high mortality rate. We present here a case of fatal acute aortic dissection in a young man who was misdiagnosed with pericarditis. We reviewed the literature of acute aortic dissection in young people and we focused particularly on clinical presentations, outcomes and investigations of aortic dissection. We report a case of a 33-year-old man with a history of uncontrolled hypertension with acute pleuretic chest pain who was transferred to our hospital for suspected pulmonary embolism and died of acute hemorragic pericardial effusion from an ascendant aortic dissection. We should never rule out aortic dissection off our differential diagnosis on the sole basis of a patient’s young age.

Pineault, Jerome; Ouimet, Denis; Pichette, Vincent; Vallee, Michel

2011-01-01

483

Misdiagnosis of epilepsy: many seizure-like attacks have a cardiovascular cause  

Microsoft Academic Search

OBJECTIVESWe sought to investigate the value of cardiovascular tests to diagnose convulsive syncope in patients with apparent treatment-resistant epilepsy.BACKGROUNDAs many as 20% to 30% of epileptics may have been misdiagnosed. Many of these patients may have cardiovascular syncope, with abnormal movements due to cerebral hypoxia, which may be difficult to differentiate from epilepsy on clinical grounds.METHODSSeventy-four patients (33 men, mean

Amir Zaidi; Peter Clough; Paul Cooper; Bruce Scheepers; Adam P Fitzpatrick

2000-01-01

484

[Stiff man syndrome and variants].  

PubMed

Stiff man syndrome (SMS) and its variants are rare neurological disorders with unusual, often awkward motor and psychological symptoms. Misdiagnoses are frequent and differentiation from psychogenic movement disorder may be difficult. Clinical suspicion can be substantiated by neurophysiological and immunological testing. Autoimmunity against certain proteins of inhibitory synapses appears to be a key feature that links SMS to other autoimmune encephalopathies and endocrinopathies. According to retrospective analyses a front-loaded long-term methylprednisolone treatment appears to be most effective. PMID:23568166

Meinck, H-M

2013-04-01

485

Experimental induction of panic-like symptoms in patients with postural tachycardia syndrome  

Microsoft Academic Search

Patients with postural tachycardia syndrome (POTS) might be misdiagnosed with panic disorder due to shared clinical features.\\u000a The first aim of our study was to investigate the relationship between symptoms of POTS and panic disorder. The second aim\\u000a was to delineate clinical features distinguishing symptoms of POTS from panic disorder. A total of 11 patients with POTS and\\u000a 11 control

Ramesh K. Khurana

2006-01-01

486

Brachial plexus neuropathy  

PubMed Central

Branchial plexus neuropathy is characterized by acute onset of intense pain in the shoulder or arm followed shortly by focal muscle weakness. This presentation may mislead the clinician into diagnosing shoulder or cervical spine pathology. Although brachial plexus neuropathy is not common, it should be considered in the differential diagnosis of pain and weakness of the arm. We present a patient with brachial plexus neuropathy who was originally misdiagnosed as having a cervical disc herniation. ImagesFigure 1Figure 2Figure 3

Hubka, Michael J; King, Laurie; Cassidy, J David; Donat, JR

1992-01-01

487

Periostitis and pseudoperiostitis.  

PubMed

Increased metabolic activity with the periosteum is demonstrated radiographically by the presence of a linear shadow of bone paralleling the cortex, most commonly reflecting increased osteoblastic activity and thus representing periosteal new bone. This is frequently seen in psoriatic arthritis and Reiter's syndrome. A similar picture occurs with increased osteoclastic activity and reflects rapid demineralization, simulating periostitis. This change must be recognized as a reflection of osteoporosis, lest the condition be misdiagnosed as inflammatory disease. PMID:1251008

Forrester, D M; Kirkpatrick, J

1976-03-01

488

Atypically distributed cutaneous lesions of Norwegian scabies in an HIV-positive man in South India: a case report  

Microsoft Academic Search

INTRODUCTION: Immune-compromised subjects, especially those with underlying HIV disease, are prone to be infected with Norwegian scabies, where the cutaneous lesions are classically distributed over the extremities. CASE PRESENTATION: We report the case of an HIV-positive 16-year-old man with severe crusted Norwegian scabies initially misdiagnosed as a dermal fungal infection. The patient had extensive, generalized, thick, hyperkeratotic, crusting, yellowish papule

Ramachandran Vignesh; Esaki Muthu Shankar; Bella Devaleenal; Pachamuthu Balakrishnan; Shieh Mark Thousen; Ramalingam Sekar; Suniti Solomon; Nagalingeswaran Kumarasamy

2008-01-01

489

Penicillium marneffei infection in a patient with SLE.  

PubMed

We describe a patient with SLE who was infected by the fungus Penicillium marneffei. She was initially misdiagnosed as having disseminated tuberculosis. The correct diagnosis was finally made by bone marrow culture and she responded to a prolonged course of amphotericin B, flucytosine and itraconazole. The clinical presentation and histology of penicilliosis are very similar to those of Mycobacterium tuberculosis. In Southeast Asia, penicilliosis should be considered as a differential diagnosis in patients with SLE who present with fever and lymphadenopathy. PMID:7655496

Lo, C Y; Chan, D T; Yuen, K Y; Li, F K; Cheng, K P

1995-06-01

490

Skin manifestations of Kikuchi-Fujimoto disease: case report and review  

Microsoft Academic Search

Kikuchi-Fujimoto disease (KFD) is a histiocytic necrotising lymphadenitis, which is a benign disease of unknown aetiology. Misdiagnosing KFD as lymphoma or systemic lupus erythematosus is not uncommon due to the similarity of clinical and histopathological features of these diseases. A 12-year-old female suffered from cervical lymphadenopathy, leukocytopenia, fever and especially skin rash. The biopsy of the lymph node was compatible

Hung-Rong Yen; Pen-Yi Lin; Wen-Yu Chuang; Min-Lin Chang; Cheng-Hsun Chiu

2004-01-01

491

[Pyomyositis: an infectious complication in systemic lupus erythematous].  

PubMed

Pyomyositis is a primary pyogenic muscular infection. It has been originally described in the tropics. Presenting signs and symptoms are not specific. It is frequently misdiagnosed in the early stages. We report the case of a 47-year-old woman with systemic lupus erythematosus treated with corticosteroids who presented a thigh pyomyositis evidenced by echography and MRI. Outcome was uneventful after antibiotics and surgical drainage. Pyomyositis is increasingly described among immunocompromised people, including lupus patients treated with corticosteroids. PMID:19362395

El Baaj, M; Tabache, F; Modden, K; Hassikou, H; Safi, S; Khalid, R; Hadri, L

2009-04-10

492

Kikuchi-Fujimoto disease--an unusual mimicker?  

PubMed

We describe the case of a 27-year-old Chinese female diagnosed with Kikuchi-Fujimoto disease in Ireland. It principally occurs in Asian populations, but is being increasingly reported in non-Asian populations. This rare, benign disease may potentially be misdiagnosed as lymphoma, and has an association with the subsequent development of systemic lupus erythematosus. Clinicians and pathologists need to be aware of the clinical and histological features of this rare disorder to avoid misdiagnosis. PMID:24157995

Scully, Diarmaid F; Walsh, Ceara; Eskander, Hala F; Kane, David

2013-09-27

493

Unusual manifestation of histoplasmosis in connective tissue diseases.  

PubMed

This report describes the coexistence of three patients with rheumatic diseases (systemic lupus erythematosus, rheumatoid arthritis, and dermatomyositis) and infections because of Histoplasma capsulatum. Connective tissue diseases and histoplasmosis share several clinical findings. Therefore, histoplasmosis could be misdiagnosed as connective tissue disease or a flare of these diseases. Such cases highlight the importance of awareness of histoplasmosis in immunocompromised patients, particularly in those originating from endemic areas. PMID:17541496

Ceccato, F; Gongora, V; Zunino, A; Roverano, S; Paira, S

2007-06-01

494

Parvovirus B19 Viremia In Egyptian Patients With Systemic Lupus Erythematosus  

Microsoft Academic Search

Background: Given that B19 infection may present with fever, rash, non-erosive arthritis, hepatitis, anemia, thrombocytopenia, leucopenia and positive ANA, B19 infection may be misdiagnosed as new onset systemic lupus erythematosus. At the same time, B19 infection and systemic lupus erythematosus may occur simultaneously in some patients. A casual relationship between B19 infection and classic idiopathic systemic lupus erythematosus has not

Nermine H. EL-Eishi; Hatem H. EL-Eishi; Olfat G. Shaker; Amira H. Soliman; Faten H. EL-Mehallawy

495

Venous Stasis Ulcers Due to Primary, Isolated Deep Venous Insufficiency in a Patient with Systemic Lupus Erythematosus: Report of a Case  

Microsoft Academic Search

.  \\u000a Primary, isolated deep venous incompetence is rare, difficult to diagnose, and can lead to the development of venous stasis\\u000a ulcers. We herein report a case demonstrating chronic venous stasis ulcers due to primary, isolated deep venous incompetence,\\u000a which was misdiagnosed as vasculitis ulcers associated with systemic lupus erythematosus (SLE). Although primary, isolated\\u000a deep venous incompetence is rare, it is

Toshiya Nishibe; Fabio Kudo; Jorge Flores; Takahiro Imai; Keiko Miyazaki; Keishu Yasuda

2002-01-01

496

Kikuchi’s disease: a review and analysis of 61 cases  

Microsoft Academic Search

OBJECTIVE: Kikuchi’s disease (KD), or histiocytic necrotizing lymphadenitis, is a rare self-limiting disorder that typically affects the cervical lymph nodes. It has occasionally been misdiagnosed as malignant lymphoma or another serious diseases; hence, clinicians should be made more aware of this disease.METHODS: From January 1986 to January 2001, a series of 61 patients who underwent a biopsy of a cervical

Hsin-Ching Lin; Chih-Ying Su; Chao-Cheng Huang; Chung-Feng Hwang; Chih-Yen Chien

2003-01-01

497

Neonatal lupus erythematosus in Thailand.  

PubMed

Systemic lupus erythematosus (SLE) is not uncommon in Thai children and adults but neonatal lupus erythematosus has never been reported in Thailand. A case of NLE born of a mother without prior history of SLE was reported. He was initially misdiagnosed as congenital self-healing histiocytosis because of seborrheic dermatitis-like lesions, petechiae, hepatosplenomegaly and thrombocytopenia. Features supporting the diagnosis of NLE in this case were presented. PMID:7822997

Chunharas, A; Tejavej, A; Hathirat, P; Janwityanuchit, S; Jarusutus, S

1993-10-01

498

Lymphocytic interstitial pneumonitis (LIP) in Sjögren’s syndrome: a case report and a review of the literature  

Microsoft Academic Search

Sjõgren’s disease is one of the most common rheumatological diseases and can present with a variety of extra-glandular manifestations.\\u000a Lymphocytic Interstitial Pneumonitis (LIP) is the most common lung pathology in these patients. It is important to know and\\u000a recognize this condition because it is potentially treatable. It is also frequently misdiagnosed and treated as infectious\\u000a pneumonia multiple times before the

Vrishali Dalvi; Emilio B. Gonzalez; Louis Lovett

2007-01-01

499

An unexpected pre-operative diagnosis.  

PubMed

This is a case report of a patient presenting with breathlessness who was thought to have suspected systemic lupus erythematosus, but was actually diagnosed with an atrial myxoma. It shows how cardiac pathology can be easily misdiagnosed as suspected pulmonary pathology and serves as a reminder to clinicians when investigating a patient with breathlessness. It also raises the question as to which patients should undergo routine pre-operative echocardiography before thoracic surgery. PMID:19939813

Hallward, G; Valchanov, K

2009-11-24

500

Venous stasis ulcers due to primary, isolated deep venous insufficiency in a patient with systemic lupus erythematosus: report of a case.  

PubMed

Primary, isolated deep venous incompetence is rare, difficult to diagnose, and can lead to the development of venous stasis ulcers. We herein report a case demonstrating chronic venous stasis ulcers due to primary, isolated deep venous incompetence, which was misdiagnosed as vasculitis ulcers associated with systemic lupus erythematosus (SLE). Although primary, isolated deep venous incompetence is rare, it is important to bear this possibility in mind when a patient presents with leg ulcers. PMID:12376799

Nishibe, Toshiya; Kudo, Fabio; Flores, Jorge; Imai, Takahiro; Miyazaki, Keiko; Yasuda, Keishu

2002-01-01