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1

Scrotal sparganosis mimicking scrotal teratoma in an infant: a case report and literature review.  

PubMed

Sparganosis is an infection with a parasitic tapeworm larva that occurs by eating infected foods or drinking contaminated water. The larvae can migrate to a tissue or muscle in the chest, abdominal wall, extremities, eyes, brain, urinary tract, pleura, pericardium, spinal canal, or scrotum. Herein, we report a 5-month old infant with scrotal sparganosis who was initially suspected to have a scrotal inflammatory mass with a history of applying raw frog meat into the umbilicus. Preoperative ultrasound examinations and computed tomography (CT) scanning misdiagnosed the mass as a scrotal teratoma. The scrotal mass was surgically removed, and the histopathology proved it to be scrotal sparganosis. This case displays the youngest patient ever reported with scrotal sparganosis, and the first description of CT characteristics of scrotal sparganosis. A detailed medical history is necessary for patients with scrotal masses suspected of sparganosis. In addition, ultrasound and CT examinations are helpful to rule out other causes of a scrotal mass. PMID:25352706

Zhao, Yi-Ming; Zhang, Hao-Chuan; Li, Zhong-Rong; Zhang, Hai-Yan

2014-10-01

2

Scrotal Sparganosis Mimicking Scrotal Teratoma in an Infant: A Case Report and Literature Review  

PubMed Central

Sparganosis is an infection with a parasitic tapeworm larva that occurs by eating infected foods or drinking contaminated water. The larvae can migrate to a tissue or muscle in the chest, abdominal wall, extremities, eyes, brain, urinary tract, pleura, pericardium, spinal canal, or scrotum. Herein, we report a 5-month old infant with scrotal sparganosis who was initially suspected to have a scrotal inflammatory mass with a history of applying raw frog meat into the umbilicus. Preoperative ultrasound examinations and computed tomography (CT) scanning misdiagnosed the mass as a scrotal teratoma. The scrotal mass was surgically removed, and the histopathology proved it to be scrotal sparganosis. This case displays the youngest patient ever reported with scrotal sparganosis, and the first description of CT characteristics of scrotal sparganosis. A detailed medical history is necessary for patients with scrotal masses suspected of sparganosis. In addition, ultrasound and CT examinations are helpful to rule out other causes of a scrotal mass.

Zhao, Yi-Ming; Zhang, Hao-Chuan; Zhang, Hai-Yan

2014-01-01

3

Angiokeratoma of vulva mimicking genital warts.  

PubMed

Angiokeratoma of vulva is a relatively rare lesion which is occasionally misdiagnosed as melanoma, pyogenic granuloma, seborrheic keratosis, or genital warts. We report a case of vulvar angiokeratomas which were diagnosed and managed as genital warts. All asymptomatic dull red-colored papules over vulva should be subjected to astute clinical and histological examination to diagnose angiokeratoma and differentiate it from other lesions. PMID:25404845

Dhawan, Amit Kumar; Pandhi, Deepika; Goyal, Surbhi; Bisherwal, Kavita

2014-12-01

4

Pulmonary sparganosis mansoni: a case report from a non-endemic region  

PubMed Central

Sparganosis mansoni is a parasitic disease caused by the larva of Spirometra mansoni. It occurs worldwide, but only a few patients show pulmonary involvement. Here, we present a case of pulmonary sparganosis mansoni in a non-endemic region. A 32-year-old Chinese woman presented with intermittent bloody phlegm, peripheral blood eosinophilia, and migratory patch shadows in both lungs. She had been misdiagnosed with eosinophilic pneumonia. She had a history of eating raw frogs, and the sparganum mansoni antibody was positive in both her blood and bronchoalveolar lavage fluid. Several sparganum mansoni were found in a frog sample that the patient provided. Consequently, she was diagnosed with pulmonary sparganosis mansoni. After two oral courses of praziquantel were administered, her symptoms and radiological lesions improved significantly. To our knowledge, this is the first case of pulmonary sparganosis mansoni occuring in Shanghai. Oral praziquantel is effective for the treatment of sparganosis mansoni, although its course of therapy may need to be repeated. PMID:24977019

Cheng, Ke-Bin; Gao, Bei-Lan; Liu, Jin-Ming

2014-01-01

5

Pulmonary sparganosis mansoni: a case report from a non-endemic region.  

PubMed

Sparganosis mansoni is a parasitic disease caused by the larva of Spirometra mansoni. It occurs worldwide, but only a few patients show pulmonary involvement. Here, we present a case of pulmonary sparganosis mansoni in a non-endemic region. A 32-year-old Chinese woman presented with intermittent bloody phlegm, peripheral blood eosinophilia, and migratory patch shadows in both lungs. She had been misdiagnosed with eosinophilic pneumonia. She had a history of eating raw frogs, and the sparganum mansoni antibody was positive in both her blood and bronchoalveolar lavage fluid. Several sparganum mansoni were found in a frog sample that the patient provided. Consequently, she was diagnosed with pulmonary sparganosis mansoni. After two oral courses of praziquantel were administered, her symptoms and radiological lesions improved significantly. To our knowledge, this is the first case of pulmonary sparganosis mansoni occuring in Shanghai. Oral praziquantel is effective for the treatment of sparganosis mansoni, although its course of therapy may need to be repeated. PMID:24977019

Cheng, Ke-Bin; Gao, Bei-Lan; Liu, Jin-Ming; Xu, Jin-Fu

2014-06-01

6

Cerebral sparganosis in mainland Chinese patients.  

PubMed

Cerebral sparganosis is a severe parasitic infection caused by the larvae of Spirometra mansoni. We retrospectively reviewed the clinical data of 26 patients with cerebral sparganosis diagnosed in our center and reviewed the literature on cerebral sparganosis in mainland China. Among our 26 patients, 20 suffered from seizures, 11 had limb weakness and 11 experienced headaches. The characteristic MRI features included ring-like enhancement in 24 patients, tunnel lesions in 14 patients and lesion migration in seven patients. Twenty-three patients underwent surgery, with the brain tissues of all patients revealling many inflammatory tunnels. Inside these tunnels, live or degenerate larvae were identified in 20 patients, but only eosinophilic tunnels were identified in the three remaining patients. All patients in this series received praziquantel, with three patients receiving praziquantel alone, with no surgical intervention, and all had a favorable outcome on long term follow-up. At least 82 patients with cerebral sparganosis with histo pathological confirmation have been reported in mainland China. The clinical course, radiological features, and pathological features of mainland Chinese patients were mostly similar to those reported in other regions. There exists an inherent correlation between radiological features and pathological changes, with worm migration causing multiple inflammatory tunnels, especially eosinophilic tunnels, which thus form the basis of tunnel-like or ring-like enhancement on multi-planar MRI, and might be predictors for a poor prognosis. Surgical therapy is optimal in the treatment for cerebral sparganosis, but medication (praziquantel and dexamethasone) has achieved favorable outcomes in some patients. PMID:23911107

Hong, Daojun; Xie, Huiqun; Zhu, Min; Wan, Hui; Xu, Renshi; Wu, Yuchen

2013-11-01

7

Verrucous carcinoma of vulva.  

PubMed

Vulval carcinoma is an uncommon disease of old women and may manifest as verrucous carcinoma. Intraepithelial cancer of the vulna of women in their twenties and thirties is increasing. Invasive carcinoma of vulva usually appears long time after intraepithelial neoplasia or chronic irritation. We are presenting one young lady of 21 years who noticed whitening of vulva since her childhood and irregular vulval itching in that area. After nine to ten years she further noticed swelling in that area which used to discharge off an on along with itching. As she got married and had disturbed sexual life, on consulting with a specialist doctor, the lesion was diagnosed as an ulcerated malignant growth. Further investigation revealed the lesion to be as verrucous carcinoma of vulva. This is the first report of such case in our country. Any persistent complaints of vulva like itching, discharge, even ulcer should be taken care of for detection of intraepithelial vulvar cancer. PMID:17917632

Kabir, N; Ara, I; Ahmed, A; Muhsin, A U

2007-07-01

8

Disorders of the Vulva  

MedlinePLUS

... the vulva. Infections (such as yeast infection) and sexually transmitted diseases , such as genital herpes , can cause vulvar signs ... years. Radiation Therapy: Treatment with high-energy radiation. Sexually Transmitted Diseases: Diseases that are spread by sexual contact, including ...

9

Leiomyosarcoma of the vulva.  

PubMed

Malignant tumors of the vulva soft tissue are uncommon. About 1-3% are sarcomas. They can be mistaken as benign lesions, leading to misdiagnosis and mistreatment. A case of a 71-year-old woman with a leiomyosarcoma of the vulva is presented. The surgical excision of the lesion is described and there were no additional malignancies or lesions found. There was no need for adjuvant therapy. PMID:22873106

Salehin, D; Haugk, C; William, M; Hemmerlein, B; Thill, M; Diedrich, K; Friedrich, M

2012-01-01

10

Sparganosis of the breast and lower extremities: sonographic appearance.  

PubMed

Sparganosis is a rare parasitic infection caused by larvae of the genus Spirometra. It can involve any part of the human body and usually manifests as a mass in various locations. We report a case of recurrent sparganosis in the breast and lower extremities. Our patient had recurrent subcutaneous masses in her breast and lower leg that showed characteristic ultrasonographic imaging findings of serpentine, tubular structures with surrounding increased echogenicity. These imaging findings are well correlated with pathologic findings. Worms were identified in resected specimens confirming sparganosis. PMID:24633936

Choi, Seung Joon; Park, Sung Hee; Kim, Min Jung; Jung, Minju; Ko, Byong Ho

2014-09-01

11

Intramuscular sparganosis in the gastrocnemius muscle: a case report.  

PubMed

Sparganosis is a parasitic infection caused by the plerocercoid tapeworm larva of the genus Spirometra. Although the destination of the larva is often a tissue or muscle in the chest, abdominal wall, extremities, eyes, brain, urinary tract, spinal canal, and scrotum, intramuscular sparganosis is uncommon and therefore is difficult to distinguish from a soft tissue tumor. We report a case of intramuscular sparganosis involving the gastrocnemius muscle in an elderly patient who was diagnosed using ultrasonography and MRI and treated by surgical excision. At approximately 1 cm near the schwannoma at the right distal sciatic nerve, several spargana worms were detected and removed. PMID:24623885

Kim, Jeung Il; Kim, Tae Wan; Hong, Sung Min; Moon, Tae Yong; Lee, In Sook; Choi, Kyung Un; Yu, Hak Sun

2014-02-01

12

Severe sparganosis in Australian tree frogs.  

PubMed

Spargana of Spirometra erinacei infect many vertebrate species, but severe disease from sparganosis has been reported from few host species. Information on the effects of this common, introduced tapeworm of cats on Australian frogs is lacking. Our survey to detect significant diseases in free-ranging amphibians in eastern Australia between 1993 and 2000 revealed that infection with spargana (plerocercoids) of S. erinacei occurred in 12/243 (4.9%) sick frogs. Infections occurred in skeletal muscle and subcutis, especially the thighs, of large adults of Litoria caerulea, Litoria aurea, Litoria gracilenta, and Litoria peronii. Three frogs were also infected in the coelomic cavity. Heavy burdens in seven frogs were associated with poor body condition and debilitating lesions, whereas lighter infections in five sick frogs were considered likely to be incidental to other diseases. In severe infections, a large proportion of thigh muscle was replaced with spargana and various amounts of fibrosis, and some frogs also had myonecrosis, granulomatous inflammation, hemorrhage, and skin ulceration. Concurrent infections were common. Our findings suggest sparganosis is one of a few currently recognized serious diseases affecting free-ranging frogs in Australia. PMID:19901368

Berger, Lee; Skerratt, Lee F; Zhu, Xing-Quan; Young, Sam; Speare, Rick

2009-10-01

13

A Case of Inguinal Sparganosis Mimicking Myeloid Sarcoma  

PubMed Central

We report here a case of inguinal sparganosis, initially regarded as myeloid sarcoma, diagnosed in a patient undergone allogeneic hematopoietic transplantation (HSCT). A 56-year-old male patient having myelodysplastic syndrome was treated with allogeneic HSCT after myeloablative conditioning regimen. At day 5 post-HSCT, the patient complained of a painless palpable mass on the left scrotum and inguinal area. Pelvic magnetic resonance imaging and computed tomography revealed suspected myeloid sarcoma. Gun-biopsy was performed, and the result revealed eosinophilic infiltrations without malignancy. Subsequent serologic IgG antibody test was positive for sparganum. Excisional biopsy as a therapeutic diagnosis was done, and the diagnosis of sparganosis was confirmed eventually. This is the first report of sparganosis after allogeneic HSCT mimicking myeloid sarcoma, giving a lesson that the physicians have to consider the possibility of sparganosis in this clinical situation and perform adequate diagnostic and therapeutic approaches. PMID:23230335

Yeo, Jin Yeob; Han, Jee Young; Lee, Jung Hwan; Park, Young Hoon; Lim, Joo Han; Lee, Moon Hee; Kim, Chul Soo

2012-01-01

14

Changes of Serum Adiponectin Levels in Murine Experimental Sparganosis  

PubMed Central

The weight gain phenomenon associated with sparganosis has been well documented and was first recognized in the 1960s. Many studies have been conducted regarding the plerocercoid growth factor in the larva of Spirometra mansoni. In the present study, we hypothesized that the weight gain may be affected by the adipocyte secreted hormones, i.e., adiponectin, which is secreted from the adipose tissues in case of tissue migrating parasitic infections. Specifically, we attempted to ascertain whether the serum levels of adiponectin change in murine sparganosis. However, serum adiponectin levels assayed by ELISA evidenced no significant changes after an experimental infection (P > 0.05). Finally, the weight gain phenomenon in mouse sparganosis is not associated with changes in adiponectin levels, and further investigations involving parasitic infection-induced weight gain remain necessary. PMID:18552545

2008-01-01

15

Aggressive Angiomyxoma of the Vulva: A Précis for Primary Care Providers  

PubMed Central

Vulvar aggressive angiomyxoma (AA) is a rare mesenchymal tumor of the vulva. Due to its slow-growing nature, it is often overlooked and misdiagnosed by primary care providers (PCPs). We describe a case report of vulvar AA in a 38-year-old woman who underwent complete surgical excision of the neoplasm with no evidence of recurrence on a 5-year followup. A literature review follows to provide PCPs with the clinical, radiologic, and pathologic features that this tumor displays. PMID:24073346

Elkattah, R.; Sarkodie, O.; Otteno, H.; Fletcher, A.

2013-01-01

16

Pruritus vulvae in prepubertal children  

Microsoft Academic Search

Background: Vulvar pruritus is a common complaint in females of all ages. However, little has been published on pruritus vulvae in children as a primary symptom. Objective: Our purpose is to review the causes and treatments of vulvar pruritus in prepubertal girls and to retrospectively evaluate the causes and outcomes of the premenarchal children we studied. Methods: The records of

Sandra C. Paek; Diane F. Merritt; Susan B. Mallory

2001-01-01

17

Villoglandular Adenocarcinoma of the Vulva  

Microsoft Academic Search

Background. Only two previous cases of villoglandular adenocarcinoma of the vulva, an entity morphologically similar to tumors found in the uterine cervix and colorectum, have been reported. This paper communicates the first complete immunohistochemical study in villoglandular adenocarcinoma in order to determine its phenotype and histogenesis.Case. A 69-year-old woman had a 1.5-cm nodule in the right labium majus. Histologically, it

Antonio Rodriguez; Mar??a Alejandra Isaac; Esther Hidalgo; Bélgica Márquez; Francisco F. Nogales

2001-01-01

18

[Preinvasive lesions in gynecology -? vulva].  

PubMed

For preinvasive lesions of vulva, a common term VIN -? vulval intraepithelial neoplasia is used. VIN is a histological dia-gnosis based on abnormal squamous epithelial proliferation. There are two types of VIN apart from their association with human papillomavirus (HPV). Undifferentiated (usual) vulval intraepithelial neoplasia is commonly associated with carcinogenic genotypes of HVP, whereas differentiated vulval intraepithelial neoplasia is not associated with high-risk genotypes of HPV. The article presents an overview of VIN occurence and epidemiology, its classification system and dia-gnostics. In conclusion, VIN therapeutical possibilities are presented. It can be treated with surgical therapy (local excision, partial vulvectomy, vulvectomy, laser vaporization) or medical therapy (imiquimod). PMID:24325163

Chovanec, J; Mouková, L; Feranec, R

2013-01-01

19

Prevalence of sparganosis by county of origin in Florida feral swine.  

PubMed

Sparganosis is a parasitic infection in amphibians, reptiles and mammals including feral swine and man. It is caused by migration of the metacestode (spargana) of Spirometra. The primary objective of this study was the determination of the prevalence of gross sparganosis in Florida county of origin in slaughtered feral swine. Tracebacks to county of origin were conducted for Florida feral swine with and without gross sparganosis. Feral swine trapped in Florida and presented for slaughter in a Texas slaughter establishment from May to December 1999 was the sample population. Overall prevalence of sparganosis in Florida feral swine was 6.9%. Because Highlands county had the same prevalence, other counties were compared to it. Sparganosis was detected in 17 Florida counties. Swine originating from Osceola or Hillsborough counties (4.3 and 1.8% prevalence, respectively) had lower prevalence of sparganosis than in Highlands, whereas those from Marion county (21.7% prevalence) had a higher prevalence. Transmission to humans may occur via consumption of infected feral swine, other species of secondary intermediate hosts or the primary intermediate hosts. PMID:11390076

Bengtson, S D; Rogers, F

2001-06-12

20

Metastatic Dermatofibrosarcoma Protuberans of the Vulva  

Microsoft Academic Search

Dermatofibrosarcoma protuberans (DFSP) of the vulva is a rare, low- to intermediate-grade sarcoma of dermal origin. This case report represents the 13th reported patient with vulvar DFSP and the first reported patient with metastatic vulvar DFSP. Although metastasis is rare, the possibility remains that the frequent recurrence of DFSP will eventually metastasize. Therefore, patients must be followed up on a

Trevor M. Soergel; David L. Doering; Dennis O'Connor

1998-01-01

21

Primary Langerhans cell histiocytosis of the vulva.  

PubMed

Primary Langerhans cell histiocytosis (LCH) of the female genital tract is very uncommon. Since the natural history of this tumor is unpredictable, with spontaneous remissions and exacerbations, establishment of the diagnosis is often difficult. In the few reported cases of LCH involving the vulva there were systemic manifestations of the disease. We report the clinical and histopathological findings in the case of a 36-year-old woman who presented with a 9-year history of vulvar lesions. The diagnosis of LCH was established by immunohistochemical techniques, which demonstrated sheets of S-100 protein-positive histiocytes in the dermal tumor. The patient received radiotherapy to the vulva and responded with complete remission. PMID:8244196

Voelklein, K; Horny, H P; Marzusch, K; Dietl, J

1993-01-01

22

Metastatic dermatofibrosarcoma protuberans of the vulva.  

PubMed

Dermatofibrosarcoma protuberans (DFSP) of the vulva is a rare, low- to intermediate-grade sarcoma of dermal origin. This case report represents the 13th reported patient with vulvar DFSP and the first reported patient with metastatic vulvar DFSP. Although metastasis is rare, the possibility remains that the frequent recurrence of DFSP will eventually metastasize. Therefore, patients must be followed up on a long-term basis to monitor the progress of this potentially lethal cancer. PMID:9826480

Soergel, T M; Doering, D L; O'connor, D

1998-11-01

23

Lifetime changes in the vulva and vagina  

Microsoft Academic Search

The morphology and physiology of the vulva and vagina change over a lifetime. The most salient changes are linked to puberty,\\u000a the menstrual cycle, pregnancy, and menopause. The cutaneous epithelia of the mons pubis, labia, and clitoris originate from\\u000a the embryonic ectoderm and exhibit a keratinized, stratified structure similar to the skin at other sites. The mucosa of the\\u000a vulvar

Miranda Farage; Howard Maibach

2006-01-01

24

Nine human sparganosis cases in Thailand with molecular identification of causative parasite species.  

PubMed

Human sparganosis is one of the neglected diseases but important food-borne parasitic zoonoses. The disease is caused by larvae (spargana) of diphyllobothriidean tapeworm. Here, we describe nine cases of human sparganosis, caused by Spirometra erinaceieuropaei in a hospital in Thailand during 2001-2012. Clinical characteristics, treatment, and outcome of cases were revealed. Diagnosis and identification of causative parasite species was made by histopathological investigations followed by a polymerase chain reaction-based molecular method using formalin-fixed paraffin embedded tissues. The DNA samples were extracted from tissues and a partial fragment of cytochrome c oxidase subunit 1 (cox1) gene was amplified for the detection of parasitic DNA. Infection could be prevented by increasing activities on health communication by responsible public health agencies. PMID:24842879

Boonyasiri, Adhiratha; Cheunsuchon, Pornsuk; Suputtamongkol, Yupin; Yamasaki, Hiroshi; Sanpool, Oranuch; Maleewong, Wanchai; Intapan, Pewpan M

2014-08-01

25

Morphogenesis of the C. elegans vulva  

PubMed Central

Understanding how cells move, change shape, and alter cellular behaviors to form organs, a process termed morphogenesis, is one of the great challenges of developmental biology. Formation of the C. elegans vulva is a powerful, simple, and experimentally accessible model for elucidating how morphogenetic processes produce an organ. In the first step of vulval development, three epithelial precursor cells divide and differentiate to generate 22 cells of seven different vulval subtypes. The 22 vulval cells then rearrange from a linear array into a tube, with each of the seven cell types undergoing characteristic morphogenetic behaviours that construct the vulva. Vulval morphogenesis entails many of the same cellular activities that underlie organogenesis and tissue formation across species, including invagination, lumen formation, oriented cell divisions, cell-cell adhesion, cell migration, cell fusion, extracellular matrix remodelling and cell invasion. Studies of vulval development have led to pioneering discoveries in a number of these processes and are beginning to bridge the gap between the pathways that specify cells and their connections to morphogenetic behaviors. The simplicity of the vulva and the experimental tools available in C. elegans will continue to make vulval morphogenesis a powerful paradigm to further our understanding of the largely mysterious mechanisms that build tissues and organs. PMID:23418408

Schindler, Adam J

2012-01-01

26

A Case of Cerebral Sparganosis : Technetium99mECD Brain SPECT experience  

Microsoft Academic Search

Cerebral sparganosis is a rare intracranial parasitic infectious disease. The best treatment seems to be the surgical removal of the worm and granuloma. However, it has not been proved possible to determine whether the worm is dead or alive by a single Brain CT or MRI findings. We report clinical and technetium-99m-ethyl cysteinate dimer (99mTc- ECD) cerebral perfusion SPECT findings

Sang Won Han; Dong Chul Park; Byung In Lee

27

Murder misdiagnosed as SIDS: a perpetrator's perspective  

PubMed Central

AIMS—Child murder misdiagnosed as sudden infant death syndrome (SIDS) is a difficult area to study. We present a perpetrator's descriptions to enrich clinicians' knowledge of possible presenting features of this phenomenon.?METHODS—Interview material was collected as part of a qualitative study of maternal filicide performed from a naturalistic paradigm in order to access the perpetrators' view of events. The woman participant has been convicted for three child murders and two attempted murders which were initially misdiagnosed as SIDS. Interviews were done in the participant's home with her partner present, while she was on leave from prison. Semi-structured interviews were conducted, recorded, transcribed, and analysed for themes. Specific ethical permission was gained to present this case in isolation and the paper was written in consultation with the woman described.?RESULTS—She described initial intense attachment to her first victim and described killing her because she was unable to bear her apnoea attacks and her fear of losing her. She described difficulty grieving for this child and subsequent failure to attach to her next child or feel for the other victims.?CONCLUSIONS—Expressions of intense attachment to an infant and description of intense grief over a death in a way which engages compassion should not deter a paediatrician from considering the possibility of the parent having killed the child.?? PMID:11719326

Stanton, J; Simpson, A

2001-01-01

28

Acute vulvar pain in a lady with post circumcision inclusion cyst of the vulva containing stones: a case report  

PubMed Central

Background Despite global eradication efforts, female genital cutting is still deep routed practice in some parts of Asia and East Africa. The crude and unscientific natures of the practice lead to many complications. Epidermoid inclusion cysts of the vulva are one of the late complications of female genital cutting and typically present as painless cystic swellings. But clinical presentation as ‘stone’ containing, hard vulvar mass is reported only once in the literature and presentation with acute vulvar pain has never been documented. Case presentation A 21 yrs old, Ethiopian, unmarried, lady presented with sever acute vulvar pain, discharge, and a stony hard vulvar swelling 13 years after type-III female genital cutting (infibulation). Surgical excision of the cyst, which contained two ‘stones’ inside it, and defibulation were done. Histopathology confirmed calcified, keratinizing epidermoid inclusion cyst of the vulva. Conclusions Clinicians, in areas where female genital cutting is prevalent, should be aware of such unusual late vulvar complication of the practice which might be misdiagnosed for other solid vulvar swellings and be familiar with the appropriate management. PMID:24387298

2014-01-01

29

The first report of sparganosis (Spirometra sp.) in Eurasian badger (Meles meles).  

PubMed

Spirometra sp. is a diphyllobothriid cestode which reproduces mainly in cat-like carnivores and canids. Several animal species that are not definitive hosts function as paratenic hosts, in which plerocercoids migrate to other tissues causing sparganosis. In this paper we describe the first case of sparganosis (Spirometra sp.) in Eurasian badger (Meles meles). It was found in an adult female Eurasian badger killed on the road in the Bia?owie?a Primeval Forest (north-eastern Poland) in April 2013. At necropsy, 128 complete and 40 fragments of plerocercoids (spargana) were found and were located subcutaneously, mainly on the hind legs and along the spine. The average length of spargana was 87±38mm. No adult Spirometra sp. tapeworms were found in the animal intestine, indicating that the investigated badger was a paratenic host for Spirometra sp. Analysis of 18S rRNA gene sequences combined with morphological examination confirmed affiliation of the concerned plerocercoids to genus Spirometra. PMID:24398022

Ko?odziej-Soboci?ska, Marta; Tokarska, Ma?gorzata; Kowalczyk, Rafa?

2014-04-01

30

[Histiocytosis X (Langerhans cell granulomatosis) of the vulva].  

PubMed

Isolated histiocytosis X (Langerhans cell granulomatosis) of the vulva is extremely rare. In most reported cases, vulval disease is associated with multitopic organ involvement. We report here on the second case in the world of isolated histiocytosis X of the vulva. The diagnosis could be established by immunohistochemical demonstration of anti-S 100 protein + Langerhans cells. The patient received a local radiation therapy of 10 gy and responded excellently. PMID:8467989

Völklein, K; Horny, H P; Marzusch, K; Dietl, J

1993-03-01

31

Autoimmune Lymphoproliferative Syndrome Misdiagnosed as Hemophagocytic Lymphohistiocytosis  

PubMed Central

Autoimmune lymphoproliferative syndrome (ALPS) is a rare inherited disorder of apoptosis, most commonly due to mutations in the FAS (TNFRSF6) gene. It presents with chronic lymphadenopathy, splenomegaly, and symptomatic multilineage cytopenias in an otherwise healthy child. Unfortunately, these clinical findings are also noted in other childhood lymphoproliferative conditions, such as leukemia, lymphoma, and hemophagocytic lymphohistiocytosis, which can confound the diagnosis. This report describes a 6-year-old girl with symptoms misdiagnosed as hemophagocytic lymphohistiocytosis and treated with chemotherapy before the recognition that her symptoms and laboratory values were consistent with a somatic FAS mutation leading to ALPS. This case should alert pediatricians to include ALPS in the differential diagnosis of a child with lymphadenopathy, splenomegaly, and cytopenias; obtain discriminating screening laboratory biomarkers, such as serum vitamin B-12 and ferritin levels; and, in the setting of a highly suspicious clinical scenario for ALPS, pursue testing for somatic FAS mutations when germ-line mutation testing is negative. PMID:24101757

Rudman Spergel, Amanda; Walkovich, Kelly; Price, Susan; Niemela, Julie E.; Wright, Dowain; Fleisher, Thomas A.

2013-01-01

32

Cases of pediatric narcolepsy after misdiagnoses.  

PubMed

Narcolepsy is characterized by recurrent brief attacks of irresistible sleepiness. Signs can begin during childhood. However, diagnoses are frequently delayed by 10-15 years because of unfamiliarity with pediatric narcolepsy and variable presentations of its associated features (cataplexy, hypnagogic/hypnopompic hallucinations, and sleep paralysis). Therefore, patients may remain untreated during their formative years. Three children with narcolepsy who were initially misdiagnosed are described. Each child's signs were initially related to depression, hypothyroidism, jaw dysfunction, or conversion disorder. However, after a multiple sleep latency test, the diagnosis of narcolepsy was established. All three patients were treated appropriately with stimulant medications, selective serotonin reuptake inhibitors, or sodium oxybate, and demonstrated positive responses. Although no definitive cure exists for narcolepsy, early recognition and appropriate symptomatic treatment with medications can allow affected children to improve quality of life and achieve normality, both academically and socially. PMID:23044019

Kauta, Shilpa R; Marcus, Carole L

2012-11-01

33

Radiofrequency ablation of a misdiagnosed Brodie's abscess  

PubMed Central

Radiofrequency ablation (RFA) therapy is recognised as a safe and effective treatment option for osteoid osteoma. This case report describes a 27-year-old man who underwent computed tomography (CT)-guided percutaneous RFA for a femoral osteoid osteoma, which was diagnosed based on his clinical presentation and CT findings. The patient developed worsening symptoms complicated by osteomyelitis after the procedure. His clinical progression and subsequent MRI findings had led to a revised diagnosis of a Brodie’s abscess, which was further supported by the eventual resolution of his symptoms following a combination of antibiotics treatment and surgical irrigations. This case report illustrates the unusual MRI features of osteomyelitis mimicking soft tissue tumours following RFA of a misdiagnosed Brodie’s abscess and highlights the importance of a confirmatory histopathological diagnosis for an osteoid osteoma prior to treatment. PMID:22291860

Chan, RS; Abdullah, BJJ; Aik, S; Tok, CH

2011-01-01

34

Vulvar intraepithelial neoplasia and microinvasive carcinoma of the vulva  

Microsoft Academic Search

The pathological, cytological, and clinical features of vulvar intraepithelial neoplasia (VIN) are described. The rate of progression of VIN III to an invasive carcinoma is very low and spontaneous regression can occur. These features prevent the drawing of a direct analogy between vulvar and cervical intraepithelial neoplasia. The concept of microinvasive carcinoma of the vulva is discussed, and it is

C H Buckley; E B Butler; H Fox

1984-01-01

35

The vulva is relatively insensitive to menses-induced irritation.  

PubMed

Skin patch testing of menses and venous blood on the vulva (labia majora) and the upper arm was performed to assess the potential contribution of these biological fluids to vulvar irritation during menstruation. After 24 and 48 hours of occlusive exposure, the skin of the labia majora was relatively unaffected by these fluids compared to the skin of the upper arm: no significant irritation was observed on the labia at either exposure time, but discernible irritation was elicited on the upper arm after 48 hours of exposure. Pre-treatment of the upper arm with a petrolatum-based emollient attenuated the upper arm response. Semi-occlusive conditions also reduced the degree of upper-arm irritation elicited test materials and an irritant control, sodium lauryl sulfate. The relative insensitivity of the vulva to irritation by menses or blood was not predictable a priori because some irritants elicit heightened responses on the vulva relative to the arm (3). These results suggest that the vulva (labia majora) may be adapted to be less sensitive to menses-induced skin irritation than other anatomical sites. PMID:17040890

Farage, Miranda; Warren, Raphael; Wang-Weigand, Sherri

2005-01-01

36

Phyllodes Tumor in Ectopic Breast Tissue of the Vulva  

Microsoft Academic Search

Phyllodes tumor arising from ectopic breast tissue of the vulva is an extremely rare occurrence. A case is reported in a 34-year-old nulligravida woman, presenting as a nodule on the left labium majus. A simple excision was carried out, and no recurrence has been detected after 18 months of follow-up.

M. T. Chulia; A. Paya; M. Niveiro; S. Ceballos; F. I. Aranda

2001-01-01

37

Germ-line induction of the Caenorhabditis elegans vulva  

E-print Network

generates the LIN-3 EGF ligand to induce vulval fates in the underlying hypo- dermis, whereas FBF, FOG-1, and FOG-3 control germ-line devel- opment. Here we report that FBF functions redundantly with FOG-1 and FOG-3 to control vulval induction: animals lacking FBF and either FOG-1 or FOG-3 have multiple vulvae

Kimble, Judith

38

Sparganosis Presenting as Cauda Equina Syndrome with Molecular Identification of the Parasite in Tissue Sections  

PubMed Central

A 52-year-old woman presented with lower back pain, progressive symmetrical paraparesis with sensory impairment, and sphincter disturbance. Magnetic resonance imaging (MRI) of the whole spine revealed multiple intradural extramedullary serpiginous-mass lesions in the subarachnoid space continuously from the prepontine to the anterior part of the medulla oblongata levels, C7, T2-T8, and T12 vertebral levels distally until the end of the theca sac and filling-in the right S1 neural foramen. Sparganosis was diagnosed by demonstration of the sparganum in histopathological sections of surgically resected tissues and also by the presence of serum IgG antibodies by ELISA. DNA was extracted from unstained tissue sections, and a partial fragment of mitochondrial cytochrome c oxidase subunit 1 (cox1) gene was amplified using a primer set specific for Spirometra spp. cox1. After sequencing of the PCR-amplicon and alignment of the nucleotide sequence data, the causative agent was identified as the larva of Spirometra erinaceieuropaei. PMID:24516282

Boonyasiri, Adhiratha; Cheunsuchon, Pornsuk; Srirabheebhat, Prajak; Yamasaki, Hiroshi; Maleewong, Wanchai

2013-01-01

39

Sparganosis presenting as cauda equina syndrome with molecular identification of the parasite in tissue sections.  

PubMed

A 52-year-old woman presented with lower back pain, progressive symmetrical paraparesis with sensory impairment, and sphincter disturbance. Magnetic resonance imaging (MRI) of the whole spine revealed multiple intradural extramedullary serpiginous-mass lesions in the subarachnoid space continuously from the prepontine to the anterior part of the medulla oblongata levels, C7, T2-T8, and T12 vertebral levels distally until the end of the theca sac and filling-in the right S1 neural foramen. Sparganosis was diagnosed by demonstration of the sparganum in histopathological sections of surgically resected tissues and also by the presence of serum IgG antibodies by ELISA. DNA was extracted from unstained tissue sections, and a partial fragment of mitochondrial cytochrome c oxidase subunit 1 (cox1) gene was amplified using a primer set specific for Spirometra spp. cox1. After sequencing of the PCR-amplicon and alignment of the nucleotide sequence data, the causative agent was identified as the larva of Spirometra erinaceieuropaei. PMID:24516282

Boonyasiri, Adhiratha; Cheunsuchon, Pornsuk; Srirabheebhat, Prajak; Yamasaki, Hiroshi; Maleewong, Wanchai; Intapan, Pewpan M

2013-12-01

40

Management of radionecrosis of the vulva and distal vagina  

SciTech Connect

Twelve patients were seen between January 1983 and June 1989 with the clinical diagnosis of radionecrosis of the vulva or distal vagina. Seven patients received radiation for vulvar cancer, three for distal vaginal cancer, and two for recurrent endometrial cancer. No patient healed spontaneously and the mean delay in surgical therapy was 8.5 months. The radionecrotic site was treated with local therapy, radical local excision (with or without colostomy), or exenteration. The operative defect was closed primarily in three patients and covered with local flaps or myocutaneous flaps in seven patients. The two patients with local care still have radionecrotic ulcers. One of three patients who were closed primarily continues to have an ulcer. All other patients have healed satisfactorily except one who died after two attempts to correct the problem. Radionecrosis of the vulva and distal vagina should generally be treated surgically.

Roberts, W.S.; Hoffman, M.S.; LaPolla, J.P.; Ruas, E.; Fiorica, J.V.; Cavanagh, D. (Univ. of South Florida, Tampa (USA))

1991-05-01

41

Report of 2 cases of misdiagnosed vesicouterine fistula.  

PubMed

Vesicouterine fistula is a rare complication that may occur after multiple cesarean deliveries. The following reports describe cases where vesicouterine fistula was misdiagnosed; one was initially treated for urge incontinence, and the other was treated for stress urinary incontinence. PMID:25185602

Petrikovets, Andrey; Lespinasse, Pierre F

2014-01-01

42

Quality of Life Among Bipolar Disorder Patients Misdiagnosed With Major Depressive Disorder  

Microsoft Academic Search

Objective: Bipolar disorder is frequently misdiagnosed as major depressive disorder (MDD). We aim to quantify the prevalence of misdiagnosed bipolar disorder among the depres- sion population and evaluate the quality-of-life (QOL) impact of misdiagnoses. Method: Data were collected from 2 self- administered, cross-sectional studies in 2003. Patients participating in The Bipolar Disorder Misdiagnosis Study (N = 1156) were previously diagnosed

A. George Awad; Krithika Rajagopalan; Susan C. Bolge; Diana D. McDonnell

2007-01-01

43

Involuntary movements misdiagnosed as seizure during vitamin B12 treatment.  

PubMed

Seizures and epilepsy are a common problem in childhood. Nonepileptic paroxysmal events are conditions that can mimic seizure and frequent in early childhood. Nonepileptic paroxysmal events can be due to physiological or exaggerated physiological responses, parasomnias, movement disorders, behavioral or psychiatric disturbances, or to hemodynamic, respiratory, or gastrointestinal dysfunction. Vitamin B12 deficiency is a treatable cause of failure to thrive and developmental regression, involuntary movements, and anemia. Involuntary movements rarely may appear a few days after the initiation of vitamin B12 treatments and might be misdiagnosed as seizure. Here, we report 2 patients who presented with involuntary movements with his video image. PMID:24196096

Carman, Kursat Bora; Belgemen, Tugba; Yis, Uluc

2013-11-01

44

Extrahepatic Textiloma Long Misdiagnosed as Calcified Echinococcal Cyst  

PubMed Central

Textiloma or gossypiboma is a retained surgical swab in the body after an operation and is a complication that can remain undetected for many years and may represent a diagnostic dilemma depending on its location. It may be confused with several focal lesions and an accurate history taking, combined with clinical and instrumental data, is key to suspecting the diagnosis. We report a case of abdominal textiloma that was initially misdiagnosed as echinococcal cyst and discuss the differential diagnosis based on sonographic features and the WHO-IWGE classification. PMID:23533840

Cattaneo, Federico; Graffeo, Massimo; Brunetti, Enrico

2013-01-01

45

The Endemic Mimic: Blastomycosis An Illness Often Misdiagnosed  

PubMed Central

One of the endemic fungi, Blastomyces dermatitidis, can cause epidemics of infection with multiple persons involved in a point source outbreak but more commonly causes sporadic cases of infection within the areas of endemicity. Blastomycosis can present as an acute pneumonia which is often misdiagnosed as acute pneumococcal pneumonia or the infection may present as a chronic pneumonia along with weight loss, night sweats, hemoptysis, and a lung mass suggesting tuberculosis or carcinoma of the lung. Extrapulmonary infection with B. dermatitidis is protean with many different manifestations. Most commonly, skin or subcutaneous lesions are found with either a verrucous or warty appearance or in an ulcerative form. Cases have been misidentified as keratoacanthoma, pyoderma gangrenosum, carcinoma, or as Weber-Christian panniculitis if there are nodular subcutaneous lesions. Essentially any site or organ can have lesions of disseminated blastomycosis. In our series, cases of laryngeal carcinoma, adrenal insufficiency, thyroid nodules, granulomatous hypercalcemia, abnormal mammograms thought to represent breast carcinoma, otitis media with cranial extension, immune thrombocytopenic purpura, and hemolytic anemia of unknown cause have been misdiagnosed and blastomycosis subsequently identified as the cause. This infection causes manifestations which mimic many other more commonly diagnosed conditions and must always be considered by clinicians practicing in the endemic region. PMID:25125734

Bradsher, Robert W.

2014-01-01

46

EBV-associated lymphoproliferative disorders misdiagnosed as Crohn's disease.  

PubMed

Epstein-Barr virus (EBV) plays an etiological role in various diseases. EBV-associated lymphoproliferative disorder (LPD) is usually observed in individuals with congenital or acquired immune deficiencies but was also recently reported in non-immunocompromised individuals. Two cases of immunocompetent patients with EBV-associated T-cell LPD of the small bowel and colon who were initially misdiagnosed as Crohn's disease (CD) are reported here. EBV-associated T-cell LPD with primary gastrointestinal tract involvement can manifest as multiple discrete ulcers of the small and/or large bowel that are similar to the lesions found in CD or intestinal tuberculosis. However, when patients have multiple intestinal ulcers that are not typical of CD or intestinal tuberculosis and the clinical course is unusual, clinicians should consider the possibility of EBV-associated LPD that involves the gastrointestinal tract because the treatment strategy and prognosis are completely different. PMID:23078910

Na, Hee Kyong; Ye, Byong Duk; Yang, Suk-Kyun; Yang, Dong-Hoon; Jung, Kee Wook; Kim, Kyung Jo; Byeon, Jeong-Sik; Myung, Seung-Jae; Huh, Jooryung; Kim, Jin-Ho

2013-09-01

47

Mohs micrographic surgery for dermatofibrosarcoma protuberans of the vulva.  

PubMed

Introduction. Dermatofibrosarcoma Protuberans (DFSP) is a rare cutaneous tumour of low/intermediate malignant potential, which occasionally arises on the vulva. Historically, the treatment has been wide local excision (WLE). Mohs micrographic surgery (MMS) is now recommended to ensure precise margin control. MMS to treat DFSP of the trunk and extremities is well documented. However, no report to date has described its use in vulval DFSP. Case History. A 39 year old woman presented with a longstanding nodule in the left labium majus. Histology after surgical removal showed an incompletely excised DFSP. MMS was undertaken with primary closure of the defect. Three years following treatment there is no evidence of recurrence. Discussion. The local recurrence rate of DFSP after WLE ranges from 0-75%. Finger-like projections from DFSP into surrounding tissue often results in incomplete excision. Representative vertical sections used in WLE assess less than 1% of the total tumour margin. MMS uses systematic horizontal sectioning. 100% of the tumour margin is microscopically examined. MMS is now advocated to ensure precise margin control. PMID:20041131

Doufekas, K; Duncan, T J; Williamson, K M; Varma, S; Nunns, D

2009-01-01

48

Mohs Micrographic Surgery for Dermatofibrosarcoma Protuberans of the Vulva  

PubMed Central

Introduction. Dermatofibrosarcoma Protuberans (DFSP) is a rare cutaneous tumour of low/intermediate malignant potential, which occasionally arises on the vulva. Historically, the treatment has been wide local excision (WLE). Mohs micrographic surgery (MMS) is now recommended to ensure precise margin control. MMS to treat DFSP of the trunk and extremities is well documented. However, no report to date has described its use in vulval DFSP. Case History. A 39 year old woman presented with a longstanding nodule in the left labium majus. Histology after surgical removal showed an incompletely excised DFSP. MMS was undertaken with primary closure of the defect. Three years following treatment there is no evidence of recurrence. Discussion. The local recurrence rate of DFSP after WLE ranges from 0–75%. Finger-like projections from DFSP into surrounding tissue often results in incomplete excision. Representative vertical sections used in WLE assess less than 1% of the total tumour margin. MMS uses systematic horizontal sectioning. 100% of the tumour margin is microscopically examined. MMS is now advocated to ensure precise margin control. PMID:20041131

Doufekas, K.; Duncan, T. J.; Williamson, K. M.; Varma, S.; Nunns, D.

2009-01-01

49

Results of vulvoplasty for treatment of recessed vulva in dogs.  

PubMed

The results of vulvoplasty were evaluated in 34 dogs that underwent surgery at the University of Wisconsin Veterinary Medical Teaching Hospital between 1987 and 1999. Case records were evaluated, and clients were interviewed by telephone. The most common clinical signs of a juvenile or recessed vulva at initial examination were perivulvar dermatitis in 59% (20/34) of dogs and urinary incontinence and chronic urinary tract infection (UTI), each present in 56% (19/34) of dogs. Other common complaints included pollakiuria, irritation, and vaginitis. Most dogs developed clinical signs before 1 year of age. All dogs except one bichon frise were medium to giant breeds, suggesting that vulvar conformation may be related to growth rate or body conformation; prior ovariohysterectomy did not appear to be an influencing factor. Eighty-two percent of owners rated the outcome of the surgery as at least satisfactory. The incidence of urinary incontinence was reduced by vulvoplasty; however, it remained the most common residual sign after surgery, suggesting a multifactorial etiology. The incidences of UTI, vaginitis, and external irritation were greatly reduced after surgery. PMID:11804321

Hammel, Scott P; Bjorling, Dale E

2002-01-01

50

Treatable Neurological Disorders Misdiagnosed as Creutzfeldt - Jakob disease  

PubMed Central

Objective Heightened awareness of Creutzfeldt-Jakob disease (CJD) among physicians and the lay public has led to its frequent consideration in the differential diagnosis of patients with rapidly progressive dementia (RPD). Our goal was to determine which treatable disorders are most commonly mistaken for CJD. Methods We performed a retrospective clinical and neuropathological review of prion-negative brain autopsy cases referred to the US National Prion Disease Pathology Surveillance Center (NPDPSC) at Case Western Reserve University from January 2006 through December 2009. Results Of 1,106 brain autopsies, 352 (32%) were negative for prion disease, 304 of which had adequate tissue for histopathological analysis. Alzheimer disease (154) and vascular dementia (36) were the two most frequent diagnoses. Seventy one patients had potentially treatable diseases. Clinical findings included dementia (42 cases), pyramidal (20), cerebellar (14), or extrapyramidal (12) signs, myoclonus (12), visual disturbance (9) and akinetic mutism (5); a typical electroencephalogram occurred only once. Neuropathological diagnoses included immune-mediated disorders (26), neoplasia (25, most often lymphoma), infections (14), and metabolic disorders (6). Interpretation In patients with RPD, treatable disorders should be considered and excluded before diagnosing CJD. Misdiagnosed patients often did not fulfill WHO criteria. RPD with positive 14-3-3 CSF protein should not be regarded as sufficient for the diagnosis of CJD. Adherence to revised criteria for CJD, which include distinctive MRI features of prion disease, is likely to improve diagnostic accuracy. PMID:21674591

Chitravas, Numthip; Jung, Richard S.; Kofskey, Diane M.; Blevins, Janis E.; Gambetti, Pierluigi; Leigh, R. John; Cohen, Mark L.

2011-01-01

51

[Two stiff person cases misdiagnosed as conversion disorder].  

PubMed

Modern psychiatric diagnostic systems classify neurological symptoms that cannot be explained by a physical disease or another psychiatric disorder as conversion disorder (CD) or dissociative motor disorder. It is a well-known fact that the overall rate of misdiagnosis of conversion symptoms is high. The most common presenting symptoms of misdiagnosed patients are gait and movement disturbances. Stiff-person syndrome (SPS) is a rare progressive autoimmune neurological disorder. The identification of antibodies against glutamic acid decarboxylase (GAD) in association with SPS provided an important contribution to the understanding of the pathophysiology of this syndrome. Patients may present with severe muscle rigidity and sudden contractions. Simultaneous contraction of agonist and antagonist muscles produces gait disturbance. SPS can be exacerbated by emotional stressors, and sudden auditory, visual, and tactile stimuli. Herein we present 2 patients that were referred for psychiatric assessment, because their neurological symptoms initially could not be explained by a neurological disease, and subsequently diagnosed as SPS. The aim of this case report is to draw attention to the psychiatric presentations of SPS and to emphasize the importance of complete psychiatric and neurological examination, including brain imaging and electrophysiological studies, in the differential diagnosis of CD. PMID:20013431

Ozer, Suzan; Ozcan, Halil; Dinç, Gülser Senses; Ertu?rul, Aygün; Rezaki, Murat; Ulu?ahin, Aylin

2009-01-01

52

Trends in Squamous Cell Carcinoma of the Vulva: The Influence of Vulvar Intraepithelial Neoplasia  

Microsoft Academic Search

Objective: To determine trends in the clinicopathology of vulvar squamous cell carcinoma over the past 2 decades, with particular reference to the possible effects of the increasing incidence of vulvar intraepithelial neoplasia (VIN) during this time.Methods: Two cohorts of 56 and 57 women with squamous cell carcinoma of the vulva and separated by at least 2 decades were reviewed retrospectively.

R. W Jones; Judith Baranyai; S Stables

1997-01-01

53

Dermatofibrosarcoma Protuberans of the Vulva: A Case Report and Review of the Literature  

Microsoft Academic Search

Objective. The purpose of this study is to describe the management of a patient with dermatofibrosarcoma protuberans (DFSP) of the vulva and to review the literature.Methods. A 39-year-old was referred by a district hospital for incomplete excision of a vulval mass. The lesion involved the left labium major and measured 8 × 12 cm. The lesion was reexcised with a

M. Moodley; J. Moodley

2000-01-01

54

Embryology and anatomy of the vulva: the female orgasm and women's sexual health  

Microsoft Academic Search

Sexual health is vital to overall well-being. Orgasm is a normal psycho-physiological function of human beings and every woman has the right to feel sexual pleasure. The anatomy of the vulva and of the female erectile organs (trigger of orgasm) is described in human anatomy textbooks. Female sexual physiology was first described in Dickinson's textbook in 1949 and subsequently by

Vincenzo Puppo

2011-01-01

55

Pristionchus pacificus vulva formation: polarized division, cell migration, cell fusion, and evolution of invagination  

Microsoft Academic Search

Tube formation is a widespread process during organogenesis. Specific cellular behaviors participate in the invagination of epithelial monolayers that form tubes. However, little is known about the evolutionary mechanisms of cell assembly into tubes during development. In Caenorhabditis elegans, the detailed step-to-step process of vulva formation has been studied in wild type and in several mutants. Here we show that

Irina Kolotuev; Benjamin Podbilewicz

2004-01-01

56

Spindle cell carcinoma of the vulva: a series of 4 cases and review of the literature.  

PubMed

Spindle cell or sarcomatoid squamous cell carcinoma is an uncommon variant of squamous cell carcinoma of the vulva (SCCV) with only 12 well-documented cases reported to date. Morphologically tumors may be biphasic or monophasic, and uncommonly include heterologous elements. Only 1 reported vulval tumor has previously been investigated for human papillomavirus DNA content. We describe 4 women with spindle cell (sarcomatoid) SCCV, 3 of which occurred de novo and 1 followed radiotherapy for previous SCCV. The tumors in all 4 women arose in a background of lichen sclerosus, and 3 were associated with vulval intraepithelial neoplasia differentiated (simplex) type. All tumors were negative for human papillomavirus DNA on polymerase chain reaction analysis. One case is the second reported with malignant heterologous elements described in the vulva. These tumors seem to be more aggressive than conventional SCCV. PMID:24487477

Bigby, Susan M; Eva, Lois J; Jones, Ronald W

2014-03-01

57

Pagetoid lesions of the vulva: a collision between malignant melanoma and extramammary Paget disease.  

PubMed

Vulvar extramammary Paget disease (EMPD) is an intraepithelial carcinoma not frequently seen in conjunction with other primary tumors. Nevertheless, we are presenting a collision between malignant nodular melanoma and EMPD in the vulva of a 78-year-old gravida 6, para 6 woman with a medical history of chronic lymphocytic leukemia. The patient presented with vulvar irritation and a pigmented vulvar mass; biopsy confirmed the diagnosis of malignant melanoma. Peripheral to the main mass, the vulva grossly seemed erythematous, and the perineum seemed white and thickened. Multiple radial biopsies were taken to determine the extent of involvement by malignant melanoma, and these biopsies revealed that the "irritated" areas surrounding the melanoma were EMPD. Subsequently, a radical vulvectomy was performed, the margins of which were clear of both neoplasms. Five months later, bilateral groin adenopathy was biopsy proven to be metastatic melanoma and chronic lymphocytic leukemia, and the patient died 8 months after the radical vulvectomy. PMID:18317209

Hill, Sarah J; Berkowitz, Ross; Granter, Scott R; Hirsch, Michelle S

2008-04-01

58

Malignant Peripheral Nerve Sheath Tumor of the Vulva: A Multimodal Treatment Approach  

Microsoft Academic Search

Background. Malignant peripheral nerve sheath tumors (MPNSTs) are rare in the gynecological population and have a high risk for local and distant failures. Multimodal management of a patient with MPNST of the vulva and review of the literature are outlined.Case. A 34-year-old woman presented with a complaint of a rapidly increasing pelvic mass, pain, and difficulty ambulating. A disfiguring 20

Nicholas C. Lambrou; Ramin Mirhashemi; Aaron Wolfson; Paul Thesiger; Manuel Penalver

2002-01-01

59

Gastric Duplication Cyst: A Rare Congenital Disease Often Misdiagnosed in Adults  

PubMed Central

Gastrointestinal duplication is a rare congenital disease which affected more commonly the ileum, while the stomach is rarely involved. Generally diagnosed in paediatric or young age, it could be difficult to suspect a gastrointestinal duplication in adults. Herein, we report a 55-year-old male with a gastric duplication cyst found on routinely checkup for chronic hepatitis and first misdiagnosed as a gastrointestinal stromal tumor (GIST); we also discuss its embryology. PMID:23476831

Falleti, Jessica; Vigliar, Elena; Zeppa, Pio; Schettino, Pietro; Napolitano, Vincenzo; D'Armiento, Maria

2013-01-01

60

An inversion in the wiring of an intercellular signal: evolution of Wnt signaling in the nematode vulva  

E-print Network

1 An inversion in the wiring of an intercellular signal: evolution of Wnt signaling in the nematode, 75251 Paris cedex 05, France. Keywords : Wnt signaling, pathway evolution, nematode vulva finds that Wnts act to repress vulval differentiation in the nematode Pristionchus pacificus 1

Paris-Sud XI, Université de

61

Intussusception in a Premature Neonate: A Rare Often Misdiagnosed Cause of Intestinal Obstruction  

PubMed Central

Intestinal obstruction in neonatal period is an emergency caused by many surgical causes. An extremely rare surgical cause in this group of age is intussusception which can be easily confused with other surgical entities. In several reports, a significant number of the infants who were included in the study population were believed to have necrotizing enterocolitis (NEC). We present a rare cause of small intestine obstruction in a preterm female infant that can be easily misdiagnosed and confused preoperatively with other clinical entities particular for this period. PMID:20049335

Loukas, I.; Baltogiannis, N.; Plataras, C.; Skiathitou, A.-V.; Siahanidou, S.; Geroulanos, G.

2009-01-01

62

Arteriovenous fistula of the filum terminale misdiagnosed and previously operated as lower lumbar degenerative disease.  

PubMed

Filum terminale arteriovenous fistula (FTAVF) presenting as a cause of failed back surgery syndrome is a rare entity. We report a 48-year-old male patient who presented with clinical features of a conus medullaris/cauda equina lesion. He had upper and lower motor neuron signs in both the lower limbs with autonomic dysfunction. The patient was misdiagnosed and was operated twice earlier for lumbar canal stenosis and disc prolapse. After reviewing his clinical and radiological findings a diagnosis of FTAVF was made. He underwent surgery and there was a significant improvement in his neurological functions. We discuss the case and review the literature on FTAVF's. PMID:24967053

Sharma, Pankaj; Ranjan, Alok; Lath, Rahul

2014-06-01

63

Neoadjuvant chemoradiotherapy followed by surgery in locally advanced squamous cell carcinoma of the vulva  

PubMed Central

Alternative therapies have been sought to alleviate mutilation and morbidity associated with surgery for vulvar neoplasms. Our prime objective was to assess tumor absence in pathological vulvar and nodal specimens following neoadjuvant chemoradiotherapy in locally advanced vulvar neoplasms. Data were retrospectively collected from January 2001 to May 2009 from 22 patients treated with neoadjuvant therapy for locally advanced squamous cell carcinoma of the vulva. Neoadjuvant treatment consisted of inguino-pelvic radiotherapy (50 Gy) in association with chemotherapy when possible. Surgery occurred at intervals of between 5 to 8 weeks. The median age of patients at diagnosis was 74.1 years. All patients were primarily treated with radiotherapy and 15 received a concomitant chemotherapy. Additionally, all patients underwent radical vulvectomy and bilateral inguino-femoral lymphadenectomy. Tumor absence in the vulvar and nodal pathological specimens was achieved for 6 (27%) patients, while absence in the vulvar pathological specimens was only achieved for 10 (45.4%) patients. Postoperative follow-up revealed breakdown of groin wounds, vulvar wounds and chronic lymphedema in 3 (14.3%), 7 (31.8%) and 14 cases (63.6%), respectively. Within a median follow-up time of 2.3 years [interquartile range (IQR), 0.6–4.6], 12 (54.6%) patients experienced complete remission and 6 cases succumbed to metastatic evolution within a median of 2.2 years (IQR, 0.6–4.6), with 1 case also experiencing perineal recurrence. Median survival time, estimated using the Kaplan-Meier method, was 5.1 years (IQR, 1.0–6.8). We suggest that neoadjuvant chemoradiotherapy may represent a reliable and promising strategy in locally advanced squamous cell carcinoma of the vulva. PMID:23205089

GAUDINEAU, A.; WEITBRUCH, D.; QUETIN, P.; HEYMANN, S.; PETIT, T.; VOLKMAR, P.; BODIN, F.; VELTEN, M.; RODIER, J.F.

2012-01-01

64

Successful Treatment of Congenital Lymphangioma Circumscriptum of the Vulva with CO2 and Long-Pulsed Nd:YAG Lasers.  

PubMed

A 16-year-old girl presented with a 9-year history of vesicles on the vulva. She had initially taken a wait-and-see approach, but required treatment because of bleeding. Histological examination of a biopsied vesicle revealed dilated lymph channels in the upper dermis, suggesting lymphangioma circumscriptum (LC). The challenge for this pathology has been to find a conservative treatment with low morbidity and better results than those reported for surgical excision, which has been the mainstay of therapy. In this case, LC of the vulva was successfully treated using a 10,600-nm CO2 laser and long-pulsed Nd:YAG laser. Use of the 10,600-nm CO2 laser and long-pulsed Nd:YAG laser appeared effective for treating LC. PMID:24575003

Sasaki, Ryosuke; Negishi, Kei; Akita, Hirotaka; Suzuki, Kayoko; Matsunaga, Kayoko

2014-01-01

65

Successful Treatment of Congenital Lymphangioma Circumscriptum of the Vulva with CO2 and Long-Pulsed Nd:YAG Lasers  

PubMed Central

A 16-year-old girl presented with a 9-year history of vesicles on the vulva. She had initially taken a wait-and-see approach, but required treatment because of bleeding. Histological examination of a biopsied vesicle revealed dilated lymph channels in the upper dermis, suggesting lymphangioma circumscriptum (LC). The challenge for this pathology has been to find a conservative treatment with low morbidity and better results than those reported for surgical excision, which has been the mainstay of therapy. In this case, LC of the vulva was successfully treated using a 10,600-nm CO2 laser and long-pulsed Nd:YAG laser. Use of the 10,600-nm CO2 laser and long-pulsed Nd:YAG laser appeared effective for treating LC. PMID:24575003

Sasaki, Ryosuke; Negishi, Kei; Akita, Hirotaka; Suzuki, Kayoko; Matsunaga, Kayoko

2014-01-01

66

[Misdiagnosed childhood sarcoidosis as non-Langerhans' cell histiocytosis treated with tumor necrosis factors-? antagonists].  

PubMed

Sarcoidosis is a chronic multisystemic granulomatous disease of unknown origin. Generalised eruptive histiocytosis is a rare, benign, self-healing, non-Langerhans' cell histiocytosis (non-LCH). We report the case of an 8-year-old girl with sarcoidosis who was misdiagnosed as non-LCH. She was treated with oral corticosteroids, methotrexate and adalimumab, but there was insufficient control of ocular disease. The introduction of infliximab achieved a control of the uveitis and enabled the corticosteroid dose to be tapered. In some cases of sarcoidosis the lack of well-organised granuloma formation at the beginning of the disease, and the presence of prominent giant cells may suggest alternative diagnoses, such as non-LCH. Although the experience of tumour necrosis factor-? antagonists use in children with sarcoidosis is limited, these drugs may be helpful for those patients experiencing a severe and refractory disease. PMID:22608978

Petiti Martin, G; Castellanos González, M; Sanz Bueno, J; Burgués Calderón, M; Villar Buil, M; Vanaclocha, F; Peralto, J L

2012-10-01

67

Robotic-Assisted Surgery Approach in a Biliary Rhabdomyosarcoma Misdiagnosed as Choledochal Cyst  

PubMed Central

Rhabdomyosarcoma is a soft tissue malignant tumor affecting 1% of children from 0 to 14 years. Preoperative imaging may not always be diagnostic for hepatobiliary rhabdomyosarcoma and differential diagnosis with choledochal cyst (CC) could be difficult. We report a case of 2-years-old girl with a strange CC pattern of presentation. A grapelike lesion involving the choledochal and biliary ducts was easily and completely resected by robotic assisted surgery. Since no previous reports were available about oncologic safety of robotic approach, the porto-enterostomy was performed in open surgery. On histologic examination, the specimen revealed a botryoidembryonal rhabdomyosarcoma affecting both the common bile duct and the common hepatic duct. One year postoperatively the child is safe of tumor relapse. Robotic approach seems to be safe and advantageous to obtain a radical excision of the tumor at the porta hepatis, even in case of misdiagnosed malignant lesion mimicking a CC. PMID:24711907

Nakib, Ghassan; Calcaterra, Valeria; Goruppi, Ilaria; Romano, Piero; Raffaele, Alessandro; Schleef, Jurgen; Pelizzo, Gloria

2014-01-01

68

Takayasu's arteritis misdiagnosed as mediastinal malignant lymphoma: a case report and review of the literature  

PubMed Central

Takayasu’s arteritis (TA) is a rare chronic large-vessel vasculitis. The early diagnosis is difficult, because of lack of characteristic clinical manifestations. In this paper, we reported a TA case of young female was misdiagnosed as mediastinal malignant lymphoma and mediastinoscope biopsy was performed. The biopsy result demonstrated that thickened tissue adjacent to the aortic arch pathological presentations were in accord with TA. Glucocorticoid was administrated and the condition was greatly improved after treatment. Therefore, we reported this case and review of the pertinent literature in order to help clinicians improve the understanding of TA and PET/CT manifestations of TA at early phase to realize the early diagnosis and treatment of TA, finally reducing the hazards. PMID:24977018

Hong, Cheng; Zeng, Tao; Zhao, Jin; Liu, Guihong

2014-01-01

69

Hereditary Spastic Paraplegia with a Novel SPAST Mutation Misdiagnosed with Subacute Combined Degeneration.  

PubMed

Autosomal dominant hereditary spastic paraplegia (AD-HSP) is due to mutations in the "spastin" gene (SPAST gene) encoding the AAA protein. The main clinical features of "pure" HSP are progressive lower-limb spasticity with corticospinal tracts and dorsal column degeneration without peripheral neuropathy. Here we report the case of HSP with novel SPAST gene mutation that misdiagnosed with subacute combined degeneration initially. A 58-year-old man with gait disturbance came to our hospital. He was unable to regulate his steps by himself. The impaired gait began 3 years after he had undergone subtotal gastrectomy and chemotherapy for 6 months. Thereafter, he started feeling tingling sensations in the hands and feet and acquired gait difficulties. He denied having a family history of abnormal gait or developmental problem. We diagnosed him with subacute combined degeneration on the evidence of history of gastrectomy, lower normal limit of vitamin B12 (363 pg/ml), apparent absence of vibration sensations and paresthesia in the feet. He was intramuscularly administered cyanocobalamin regularly. However, there was no improvement in his condition. We reconsidered his symptoms and signs, decided to examine the SPAST gene, which is the most common mutation in HSP. The SPAST gene, c.870+1delG, heterozygote, splicing mutation is detected from the gene sample. There was no previous information of this polymorphism or mutation at this locus. We examined his two children, and the same mutation was founded in his son. We report a patient of novel SPAST gene mutation with AD-HSP which is misdiagnosed with SCD. PMID:23833562

Yang, Ji Won; Han, Ji-Young; Seong, Moon-Woo; Sung, Jung-Joon; Park, Sung Sup; Lee, Kwang-Woo

2013-06-01

70

Immunohistochemical expression of p16 and p53 in vulvar intraepithelial neoplasia and squamous cell carcinoma of the vulva  

Microsoft Academic Search

This study was undertaken to examine the expression of p16 and p53 in vulvar intraepithelial neoplasia (VIN) and squamous\\u000a cell carcinoma (SCC) of the vulva. We also analyzed the relationship between p16 and p53 immunoexpression in women younger\\u000a vs. older than 55 years of age. Seventyseven histologic samples of vulvar tissue, treated surgically between June 2000 and\\u000a November 2004 at

Mauricio Cordoni Nogueira; Ernesto de Paula Guedes Neto; Marcos Wengrover Rosa; Eduardo Zettler; Cláudio Galleano Zettler

2006-01-01

71

Tumor-to-tumor metastasis with endometrial carcinoma metastatic to squamous cell carcinoma of vulva: the first reported case.  

PubMed

Endometrial carcinoma metastasizing to the vulva is a rare occurrence, with only 15 reported cases in the literature. To our knowledge, no cases of tumor-to-tumor metastasis involving endometrial carcinoma as a donor tumor have ever been published. We report the first case of an endometrial carcinoma as a donor tumor metastasizing to a squamous cell carcinoma of the vulva, a recipient tumor. A 79-year-old woman with a history of endometrioid adenocarcinoma of the uterus presented with a vulvar lesion. Pathologic examination of the excised lesion confirmed the presence of metastatic endometrioid adenocarcinoma; however, it was found within a well-differentiated squamous cell carcinoma of the vulva. Surrounding the squamous cell carcinoma was a background of a high-grade vulvar intraepithelial lesion (vulvar intraepithelial neoplasia 3), and immunohistochemistry confirmed the presence of 2 separate tumors involved in a tumor-to-tumor metastasis. This unique case highlights the importance of awareness of the phenomenon, and expands the current spectrum of tumor-to-tumor metastases. PMID:24283863

Wimmer, Jana L; Coffey, Donna M; Kaplan, Alan L; Ayala, Alberto G; Ro, Jae Y

2013-12-01

72

Lymphomatoid papulosis misdiagnosed as pityriasis lichenoides et varioliformis acuta: Two case reports and a literature review  

PubMed Central

The aim of this study was to improve the level of diagnosis and differential diagnosis of lymphomatoid papulosis (LyP). Two cases of type B LyP were identified and the literature was reviewed to summarize the clinical outcomes and pathology of LyP and its treatment. The two patients exhibited symptoms with papulonodular lesions, the centers of which gradually underwent ulceration and necrosis. CD30, a helper T-cell marker specifically expressed in tumor cells was analyzed by immunohistochemical staining and the result showed that CD30-negative or only scattered CD30-positive cells were present. Therefore, a diagnosis of type B LyP was made. A fairly good curative effect was achieved following treatment with retinoic acid, glucocorticoids and immunomodulatory drugs. LyP is a type of low-level malignant lymphoma and is easily misdiagnosed as pityriasis lichenoides et varioliformis acuta and other diseases. In order to avoid under diagnosis and misdiagnosis, doctors should evaluate suspected patients by histopathological and immunohistochemical examination. PMID:25371758

ZHENG, YAN; JIA, JINJING; TIAN, QIONG; DONG, XINYU; WANG, XIN; YING, ZHAOXIA; XIAO, SHENGXIANG; LI, WENSHENG

2014-01-01

73

Case report of narcolepsy in a six-year-old child initially misdiagnosed as atypical epilepsy  

PubMed Central

Summary This report describes a case of first-onset narcolepsy in a six-year-old female that was misdiagnosed as atypical epilepsy and other diagnoses at eight different hospitals over a period of 10 months before the correct diagnosis was made. The diagnosis of narcolepsy is more difficult in children because very few of them experience all four cardinal symptoms of narcolepsy – paroxysmal sleep, cataplexy, hypnagogic hallucination, and sleep paralysis – and they often have a more prolonged onset and diverse symptoms. To decrease the time lag between initial presentation and accurate diagnosis, we recommend that in all cases in which children report excessive sleep of unknown etiology – regardless of the associated symptoms – that sleep monitoring and sleep latency tests be conducted to rule out the possibility of narcolepsy. The case highlights the wide variety of presentations of uncommon psychiatric conditions, particularly in children, and the need for clinicians to be aware of the atypical presentations of these conditions when collecting medical histories.

ZHOU, Jinquan; ZHANG, Xi; DONG, Zaiwen

2014-01-01

74

A case of diffuse large B-cell lymphoma misdiagnosed as an erysipelas of the face  

PubMed Central

We report a case of a woman with diffuse large B-cell lymphoma (DLBCL). Primary cutaneous lymphomas (PCLs) represent distinct clinical and histopathologic subtypes of extranodal T- and B-cell lymphomas. Cutaneous B-cell lymphomas comprise 20–25% of all primary cutaneous lymphomas. The patient presented an erythematous tumour mass of the left nasolabial fold, nose and left cheek as well as disseminated infiltrative plagues on the trunk, arms and left lower leg. Skin biopsy revealed a diffuse infiltrate of lymphocytes around hair follicles and blood vessels within dermis and subcutaneous tissue. An immunohistochemistry showed a diffuse infiltrate of large non-cleaved B-cells, with a high proportion of centroblast-like cells within dermis. Tumor cells expressed CD20, bcl-2 protein and did not express CD10. The patient was misdiagnosed as the erysipelas of the face and unsuccessfully treated with long-term antibiotic therapy by a laryngologist and a dermatologist. The correct diagnosis was delayed and established after 6 months’ history of DLBCL lesions. Therefore, we would like to strongly stress the importance of considering diagnosis of cutaneous lymphomas in chronic skin lesions non-responsive to adequate therapies. PMID:24278087

Szymanska, Magdalena; Czarnecka-Operacz, Magdalena

2013-01-01

75

A case of diffuse large B-cell lymphoma misdiagnosed as an erysipelas of the face.  

PubMed

We report a case of a woman with diffuse large B-cell lymphoma (DLBCL). Primary cutaneous lymphomas (PCLs) represent distinct clinical and histopathologic subtypes of extranodal T- and B-cell lymphomas. Cutaneous B-cell lymphomas comprise 20-25% of all primary cutaneous lymphomas. The patient presented an erythematous tumour mass of the left nasolabial fold, nose and left cheek as well as disseminated infiltrative plagues on the trunk, arms and left lower leg. Skin biopsy revealed a diffuse infiltrate of lymphocytes around hair follicles and blood vessels within dermis and subcutaneous tissue. An immunohistochemistry showed a diffuse infiltrate of large non-cleaved B-cells, with a high proportion of centroblast-like cells within dermis. Tumor cells expressed CD20, bcl-2 protein and did not express CD10. The patient was misdiagnosed as the erysipelas of the face and unsuccessfully treated with long-term antibiotic therapy by a laryngologist and a dermatologist. The correct diagnosis was delayed and established after 6 months' history of DLBCL lesions. Therefore, we would like to strongly stress the importance of considering diagnosis of cutaneous lymphomas in chronic skin lesions non-responsive to adequate therapies. PMID:24278087

Teresiak-Miko?ajczak, Ewa; Szyma?ska, Magdalena; Czarnecka-Operacz, Magdalena

2013-08-01

76

Metastatic Uterine Leiomyosarcoma in the Upper Buccal Gingiva Misdiagnosed as an Epulis  

PubMed Central

Uterine leiomyosarcoma (LMS) is a rare tumor constituting 1% of all uterine malignancies. This sarcoma demonstrates an aggressive growth pattern with an high rate of recurrence with hematologic dissemination; the most common sites are lung, liver, and peritoneal cavity, head and neck district being rarely interested. Only other four cases of metastasis in the oral cavity have been previously described. The treatment of choice is surgery and the use of adjuvant chemotherapy and radiation has limited impact on clinical outcome. In case of metastases, surgical excision can be performed considering extent of disease, number and type of distant lesions, disease free interval from the initial diagnosis to the time of metastases, and expected life span. We illustrate a case of uterine LMS metastasis in the upper buccal gingiva that occurred during chemotherapy in a 63-year-old woman that underwent a total abdominal hysterectomy with bilateral salpingo-oophorectomy for a diagnosis of LMS staged as pT2bN0 and that developed lung metastases eight months after primary treatment. Surgical excision of the oral mass (previously misdiagnosed as epulis at a dental center) and contemporary reconstruction with pedicled temporalis muscle flap was performed in order to improve quality of life. Even if resection was achieved in free margins, “local” relapse was observed 5 months after surgery.

Cassoni, Andrea; Terenzi, Valentina; Bartoli, Davina; Zadeh, Oriana Rajabtork; Battisti, Andrea; Pagnoni, Mario; Conte, Davide; Lembo, Alessandro; Bosco, Sandro; Alesini, Francesco; Valentini, Valentino

2014-01-01

77

Metastatic uterine leiomyosarcoma in the upper buccal gingiva misdiagnosed as an epulis.  

PubMed

Uterine leiomyosarcoma (LMS) is a rare tumor constituting 1% of all uterine malignancies. This sarcoma demonstrates an aggressive growth pattern with an high rate of recurrence with hematologic dissemination; the most common sites are lung, liver, and peritoneal cavity, head and neck district being rarely interested. Only other four cases of metastasis in the oral cavity have been previously described. The treatment of choice is surgery and the use of adjuvant chemotherapy and radiation has limited impact on clinical outcome. In case of metastases, surgical excision can be performed considering extent of disease, number and type of distant lesions, disease free interval from the initial diagnosis to the time of metastases, and expected life span. We illustrate a case of uterine LMS metastasis in the upper buccal gingiva that occurred during chemotherapy in a 63-year-old woman that underwent a total abdominal hysterectomy with bilateral salpingo-oophorectomy for a diagnosis of LMS staged as pT2bN0 and that developed lung metastases eight months after primary treatment. Surgical excision of the oral mass (previously misdiagnosed as epulis at a dental center) and contemporary reconstruction with pedicled temporalis muscle flap was performed in order to improve quality of life. Even if resection was achieved in free margins, "local" relapse was observed 5 months after surgery. PMID:25386373

Cassoni, Andrea; Terenzi, Valentina; Bartoli, Davina; Zadeh, Oriana Rajabtork; Battisti, Andrea; Pagnoni, Mario; Conte, Davide; Lembo, Alessandro; Bosco, Sandro; Alesini, Francesco; Valentini, Valentino

2014-01-01

78

Uterine leiomyoma associated non-puerperal uterine inversion misdiagnosed as advanced cervical cancer: A case report?  

PubMed Central

INTRODUCTION Uterine inversion is an un-common complication of parturition which often occurs in the immediate postpartum period. The chronic (non-puerperal) uterine inversion is rarer and most times tumour associated. PRESENTATION OF CASE A 51-year old grand multiparous lady presented with a month history of abnormal vaginal bleeding associated with offensive vaginal discharge, lower abdominal pain and dizziness. The initial evaluation suggested severe anaemia secondary to advanced cervical cancer. Examination under anaesthesia (EUA), staging and biopsy was attempted but this was however inconclusive due to profuse haemorrhage. A repeat EUA revealed chronic uterine inversion secondary to fundal submucous uterine leiomyoma. Myomectomy was done with tissue histology confirming benign uterine leiomyoma. Two weeks later, a modified Haultain's procedure was done followed by simple hysterectomy and posterior colpoperineorrhaphy. She had satisfactory recovery. DISCUSSION This is the first reported case of chronic non-puerperal uterine inversion in our hospital. When it occurs, it is usually tumour associated with the commonest tumour being prolapsed myoma and leiomyosarcoma. The diagnosis is based on high index of suspicion. CONCLUSION Chronic uterine inversion is a rare gynaecological condition and can be misdiagnosed as advanced cervical cancer or other causes of severe genital haemorrhage in women. A high index of suspicion is needed for its proper diagnosis. Sometimes, an EUA and biopsy was required to determine the cause here and conveniently it could be described as a “gynaecolological near miss”. PMID:24091076

Umeononihu, Osita Samuel; Adinma, Joseph Ifeanyi; Obiechina, Nworah J.; Eleje, George Uchenna; udegbunam, Onyebuchi Izuchukwu; Mbachu, Ikechukwu Innocent

2013-01-01

79

Premalignant lesions of the lower female genital tract: cervix, vagina and vulva.  

PubMed

Premalignant lesions of the lower female genital tract encompassing the cervix, vagina and vulva are variably common and many, but by no means all, are related to infection by human papillomavirus (HPV). In this review, pathological aspects of the various premalignant lesions are discussed, mainly concentrating on new developments. The value of ancillary studies, mainly immunohistochemical, is discussed at the appropriate points. In the cervix, the terminology and morphological features of premalignant glandular lesions is covered, as is the distinction between adenocarcinoma in situ (AIS) and early invasive adenocarcinoma, which may be very problematic. A spectrum of benign, premalignant and malignant cervical glandular lesions exhibiting gastric differentiation is emerging with lobular endocervical glandular hyperplasia (LEGH), including so-called atypical LEGH, representing a possible precursor of non HPV-related cervical adenocarcinomas exhibiting gastric differentiation; these include the cytologically bland adenoma malignum and the morphologically malignant gastric type adenocarcinoma. Stratified mucin producing intraepithelial lesion (SMILE) is a premalignant cervical lesion with morphological overlap between cervical intraepithelial neoplasia (CIN) and AIS and which is variably regarded as a form of reserve cell dysplasia or stratified AIS. It is now firmly established that there are two distinct types of vulval intraepithelial neoplasia (VIN) with a different pathogenesis, molecular events, morphological features and risk of progression to squamous carcinoma. These comprise a more common HPV-related usual type VIN (also referred to as classic, undifferentiated, basaloid, warty, Bowenoid type) and a more uncommon differentiated (simplex) type which is non-HPV related and which is sometimes associated with lichen sclerosus. The former has a relatively low risk of progression to HPV-related vulval squamous carcinoma and the latter a high risk of progression to non-HPV related vulval squamous carcinoma. Various aspects of vulval Paget's disease are also discussed. PMID:23442737

McCluggage, W Glenn

2013-04-01

80

Dermatofibrosarcoma protuberans of the vulva: a clinicopathologic and immunohistochemical study of 13 cases.  

PubMed

Dermatofibrosarcoma protuberans (DFSP) is a low-grade sarcoma seldom seen in the vulva with only 29 cases reported. We present the clinicopathologic and immunohistochemical features of 13 such cases seen in our institution over a period of 29 years (1978 to 2007). Patient age ranged from 23 to 76 years (mean, 46 y). Twelve patients had a vulvar mass. One patient presented with a pigmented skin lesion. Tumor size ranged from 1.2 to 15 cm (median, 4 cm). Microscopically, all the cases showed typical features of DFSP. In 1 case, myxoid changes were also noted; 3 cases showed fibrosarcomatous transformation. Of interest, in 7 of our 13 cases, a variety of diagnoses, such as cellular dermatofibroma, cellular leiomyoma, neurofibroma, low-grade leiomyosarcoma, fibrosarcoma, low-grade malignant schwannoma, desmoplastic melanoma, cellular neurofibroma, and low-grade malignant peripheral nerve sheet tumor were initially considered. All 11 cases tested for CD34 were positive, whereas 7/9 cases, 8/9 cases, and 9/9 cases were positive for PDGFR-alpha, PDGFR-beta, and c-abl, respectively. All patients were initially treated with excisional biopsy, wide local excision, or radical vulvectomy. Local recurrences occurred in 7 cases. One patient also developed distant metastases. All recurrences were treated surgically; 1 patient also received chemotherapy and radiotherapy and another received imatinib (Gleevec). Follow-up data ranging from 2 to 444 months was available for all patients. Nine patients had no evidence of disease, 2 patients were alive with disease, 1 patient had died of disease, and 1 patient had died of other causes. DFSP affects women of a wide age range and has a propensity to recur locally. The frequent expression of PDGFR-alpha, PDGFR-beta, and c-abl in these cases agrees with the findings of other investigators and supports the use of imatinib (Gleevec) in cases that are recurrent or not amenable to surgery. PMID:20139758

Edelweiss, Marcia; Malpica, Anais

2010-03-01

81

Oncogenic viruses associated with vulva cancer in HIV-1 patients in Botswana  

PubMed Central

Background Oncoviruses such as HPV, KSHV, and EBV have been reported in patients with HIV infection and AIDS. How oncovirus-associated cancers rise in AIDS patients has not been fully established. The purpose of our study was to identify the viral agents in vulvar cancer and to assess their contribution to pathogenesis. Method We retrospectively identified a total of 13 vulva tissue samples from HIV-1 positive and 9 vulvar samples from HIV-1 negative patients from the Botswana National Health Laboratory in Gaborone, Botswana, a Southern African country with a high incidence of HIV. We utilized PCR and IHC to identify HPV, EBV, KSHV, and JC virus in FFPE preserved tissue samples. Results Using the GP5+/GP6+ primer set we detected several HPV types in tissue samples. EBV was detected in all of the positive cases (100%) and in most of the negative cases (89%). KSHV was detected in 39% of the HIV-1 positive samples and in 11% of the negative samples, and no JC virus was detected in any of the samples. Using IHC we demonstrated that LANA was expressed in 61% of the positive samples and in 44% of the negative samples. The ubiquitous EBV was more consistently expressed in negative cases (100%) than in positive cases (69%). Interestingly, the HPV-16 E6 transcript was detected in 56% of the negative samples compared to 31% of the positive samples. However, the cell cycle protein P21 used as a surrogate marker for HPV was detected in 77% of the positive samples and in 44% of the negative samples, while VEGF signals were similar in both positive (92%) and negative samples (89%). Conclusion Our study, suggests that in Botswana, vulvar squamous cell carcinoma (VSCC) is associated with oncogenic viruses present in the niche but the contribution and progression may be regulated by HPV and other immunosuppressive infections that include HIV-1. PMID:25225572

2014-01-01

82

Localized amyloidosis of the vulva with and without vulvar intraepithelial neoplasia: report of a series.  

PubMed

Localized primary cutaneous amyloidosis is uncommon in Europe and North America and is infrequently reported in the English literature. The constituents of such deposits have not been previously examined; this series characterizes amyloid deposits in localized vulvar amyloidosis and their association with vulvar intraepithelial neoplasia. All biopsies and excisions of vulva over 18 months were reviewed. Cases with suspected amyloidosis were retrieved after institutional review board approval. Twenty cases mimicking amyloidosis were selected as controls. All study and control cases were stained with Congo red. Four Congo red-positive study cases were studied by liquid chromatography-tandem mass spectrometry. Of 27 Congo red-positive study cases, 25 were then examined by immunohistochemical stains with antibodies to cytokeratin 5 (CK5) and cytokeratin 14 (CK14). Of 149 cases reviewed, 26 localized and 1 systemic vulvar amyloidosis were identified. Liquid chromatography-tandem mass spectrometry analysis of the deposits revealed unique peptide profile consistent with CK5 and CK14. Immunohistochemical staining with antibodies to CK5 and CK14 also detected these components in the deposits. The vulvar deposit of systemic amyloidosis consisted of amyloid light chain (?)-type amyloid deposit. All control cases were negative for Congo red. Keratin-associated amyloid materials (CK5 and CK14) were found to be unique in localized vulvar amyloidosis. Leakage of keratins from the basal layer of the epithelium into the superficial dermis may have been the possible source of the deposits. It appears to be associated with both high-grade and low-grade vulvar intraepithelial neoplasias and, rarely, lichen sclerosus, seborrheic keratosis, and benign vulvar skin. PMID:25149547

Quddus, M Ruhul; Sung, C James; Simon, Rochelle A; Lawrence, W Dwayne

2014-10-01

83

Unusual mucoepidermoid carcinoma of the liver misdiagnosed as squamous cell carcinoma by intraoperative histological examination  

PubMed Central

As rare condition, mucoepidermoid carcinoma may occur in liver although its etiology and pathogenesis is still unclear. We report here a case of intrahepatic mucoepidermoid carcinoma misdiagnosed as cholangiocarcinoma and squamous cell carcinoma by preoperative radiologic and intraoperative histological examinations, respectively. A 60-year-old woman presented with a 1-month history of progressive jaundice, epigastric discomfort, and weight loss with slightly increased carbohydrate antigen 19-9 (CA19-9). Computed tomography (CT) showed a large tumor, 8.0 cm in diameter, in the left lobe of the liver. A preliminary diagnosis of a cholangiocarcinoma of the liver was made. In the intraoperative histological examination, a diagnosis of squamous cell carcinoma was made based on predominantly invasive epidermoid cells with abundant keratinization and absence of mucin-producing cell component. However, postoperative histological diagnosis of the lesion was mucoepidermiod carcinoma of liver by thoroughly microscopical inspection and the presence of mucin-producing cells confirmed by Alcian blue staining. Despite surgical excision and chemotherapy, the tumor showed very aggressive malignancy with tumor recurrence. The patient died shortly afterward, surviving 6 months after surgery. Due to its rarity and distinct morphological features, mucoepidermoid carcinoma might be erroneously interpreted as squamous cell carcinoma by those who were not familiar with this condition in unusual locations. Therefore, removal of sufficient tissue from different portions of the lesion is essential for the surgeons and pathologists to make a precise diagnosis in the intraoperative histological examination. Virtual slide The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/4956311271136060 PMID:24475740

2014-01-01

84

Efficacy of inosine pranobex oral therapy in subclinical human papillomavirus infection of the vulva: a randomized double-blinded placebo controlled study.  

PubMed

A randomized double-blind placebo controlled study was carried out to assess the efficacy of inosine pranobex (1 g orally 3 times a day for 6 weeks) in the treatment of symptomatic subclinical human papillomavirus infection of the vulva. In a series of 55 women, 22 patients in the inosine pranobex group and 24 patients in the placebo group were suitable for analysis. A total of 14 (63.5%) of the inosine pranobex treated patients and 4 (16.7%) of the placebo treated patients showed significant vulval epithelial morphological improvement (P = 0.005) at 2 months after initiation of treatment. Whereas 13 (59.1%) and 9 (37.5%) patients in the respective groups showed significant improvement in the severity of pruritus vulvae (P = 0.435). Twelve (66.7%) of 18 patients with morphological improvement compared to 10 (35.7%) of 28 patients with no morphological improvement experienced significant symptomatic alleviation of pruritus vulvae (P = 0.041). Similar results were seen at the second assessment 4 months after the initiation of treatment. Adverse drug reactions were reported by 2 patients in the treatment group and by 2 patients (skin rash) in the placebo group. These adverse reactions were mild and self limiting. It is concluded that inosine pranobex demonstrated a significant pharmacological activity in subclinical HPV infection of the vulva and should be considered an alternative treatment for the condition. PMID:8876359

Tay, S K

1996-07-01

85

Nonlesions, misdiagnoses, missed diagnoses, and other interpretive challenges in fish histopathology studies: a guide for investigators, authors, reviewers, and readers  

USGS Publications Warehouse

Differentiating salient histopathologic changes from normal anatomic features or tissue artifacts can be decidedly challenging, especially for the novice fish pathologist. As a consequence, findings of questionable accuracy may be reported inadvertently, and the potential negative impacts of publishing inaccurate histopathologic interpretations are not always fully appreciated. The objectives of this article are to illustrate a number of specific morphologic findings in commonly examined fish tissues (e.g., gills, liver, kidney, and gonads) that are frequently either misdiagnosed or underdiagnosed, and to address related issues involving the interpretation of histopathologic data. To enhance the utility of this article as a guide, photomicrographs of normal and abnormal specimens are presented. General recommendations for generating and publishing results from histopathology studies are additionally provided. It is hoped that the furnished information will be a useful resource for manuscript generation, by helping authors, reviewers, and readers to critically assess fish histopathologic data.

Wolf, Jeffrey C.; Baumgartner, Wes A.; Blazer, Vicki S.; Camus, Alvin C.; Engelhardt, Jeffrey A.; Fournie, John W.; Frasca, Salvatore, Jr.; Groman, David B.; Kent, Michael L.; Khoo, Lester H.; Law, Jerry M.; Lombardini, Eric D.; Ruehl-Fehlert, Christine; Segner, Helmut E.; Smith, Stephen A.; Spitsbergen, Jan M.; Weber, Klaus; Wolfe, Marilyn J.

2014-01-01

86

A case of dermatofibrosarcoma protuberans of the vulva with a COL1A1\\/PDGFB fusion identical to a case of giant cell fibroblastoma  

Microsoft Academic Search

Dermatofibrosarcoma protuberans (DFSP) is a highly recurrent low-grade soft tissue sarcoma, which is usually located on the\\u000a trunk. Presentation in the vulva is rare, with only 13 cases being reported to date, none of which have been investigated\\u000a at the cytogenetic or molecular level. Specific cytogenetic abnormalities, involving chromosomes 17 and 22, are characteristic\\u000a features of DFSP and giant cell

Roberta Vanni; Gavino Faa; Tinuccia Dettori; Gian B. Melis; Jan P. Dumanski; Kevin P. O’Brien

2000-01-01

87

Dermatofibrosarcoma protuberans of the vulva: clinicopathologic and immunohistochemical analysis of four cases, one with fibrosarcomatous change, and review of the literature.  

PubMed

Only 18 cases of dermatofibrosarcoma protuberans (DFSP) of the vulva have been reported. This article describes the clinicopathologic and immunohistochemical findings of four additional vulvar DFSPs. The median patient age was 54 years (range, 36 to 69 years) and the most common clinical presentation was a slowly growing vulvar mass. The tumors occurred in the left paraclitoral area (1 case), right labium majus (1 case), left labium majus (1 case), and mons pubis (1 case). The tumor size, known in three cases, ranged from 1.2 to 5.0 cm in greatest dimension. Microscopically, the tumors were composed of bland spindle cells with oval or wavy nuclei arranged in a cartwheel pattern; in one case, fibrosarcomatous areas were apparent. CD34 immunostaining was positive in the three cases in which it was performed; positive staining was also seen in the area of fibrosarcoma. Estrogen and progesterone receptor immunostains were negative in three cases. Of the three patients who underwent surgery, one had tumor recurrences every 2 to 4 years for 18 to 20 years but has remained free of tumor in the 7 years since the last excision, one was free of tumor for 12 years before dying of an unrelated cause, and the other has been free of disease for 6 months. The fourth patient refused treatment and has persistent disease in the vulva. This study shows that the behavior of DFSP in the vulva is similar to its behavior in its more common locations. PMID:10542946

Ghorbani, R P; Malpica, A; Ayala, A G

1999-10-01

88

Defining the concept of locally advanced squamous cell carcinoma of the vulva: a new perspective based on standardization of criteria and current evidence.  

PubMed

The phrase "locally advanced carcinoma of the vulva" has often been mentioned in the literature, though not accurately defined, or even leading to the interpretation overlapping. Grounded on cervical cancer experience, we are able to state that designing a tailored primary strategy based on clinically measurable adverse prognostic factors represents the cornerstone of therapy. This fact urged us to rethink about the real usefulness of the concept of locally advanced squamous cell carcinoma of the vulva. We will refer to this concept as a clinical entity emerging from a rigorous workup which is a valuable guiding tool in the context of a thorough debate about the best primary treatment approach to be used. Furthermore, bulky tumors of the vulva have been associated with a worse prognosis on several occasions. Some authors have questioned the fact that tumor size has not been considered in the staging system. Finally, a standardized definition will help us compare the results obtained, which is extremely necessary given the worldwide low prevalence of this disease. PMID:25142626

Aragona, Alejandro M; Soderini, Alejandro H; Cuneo, Nicasio A

2014-10-01

89

Defining the concept of locally advanced squamous cell carcinoma of the vulva: a new perspective based on standardization of criteria and current evidence  

PubMed Central

The phrase "locally advanced carcinoma of the vulva" has often been mentioned in the literature, though not accurately defined, or even leading to the interpretation overlapping. Grounded on cervical cancer experience, we are able to state that designing a tailored primary strategy based on clinically measurable adverse prognostic factors represents the cornerstone of therapy. This fact urged us to rethink about the real usefulness of the concept of locally advanced squamous cell carcinoma of the vulva. We will refer to this concept as a clinical entity emerging from a rigorous workup which is a valuable guiding tool in the context of a thorough debate about the best primary treatment approach to be used. Furthermore, bulky tumors of the vulva have been associated with a worse prognosis on several occasions. Some authors have questioned the fact that tumor size has not been considered in the staging system. Finally, a standardized definition will help us compare the results obtained, which is extremely necessary given the worldwide low prevalence of this disease.

Soderini, Alejandro H.; Cuneo, Nicasio A.

2014-01-01

90

[Report of a case of glucagonoma misdiagnosed as "eczema" and "hepatic angioma" for three years and review of literature].  

PubMed

Glucagonoma is a rare pancreatic tumor, necrolytic migratory erythema is its distinctive feature and it is often associated with diabetes mellitus, weight loss, anemia, hypoaminoacidemia, glossitis and stomatitis. We reported a case of glucagonoma misdiagnosed as "eczema" and "benign hepatic anginoma" for 3 years. His blood glucagon level was 1,758 ng/L. The results of abdominal B-mode ultrasonography and CT scan were negative, but selected arteriogram showed a tumor mass between the pancreatic body and tail. Before operation, treatment with octreotide and supply of amino acids were given with improvement of the skin lesion. After resection of the tumor from pancreas, necrolytic migratory erythema disapeared, but his blood level of glucagon and amino acids did not improve. It is suggested that any diabetic patient with chronic skin damage should be checked for blood glucagon level. In suspected cases, selected arteriogram will be helpful for location of the tumor. Vigorous resection of the pancreatic tumor should be done as soon as possible, even though there is already metastases. PMID:7648942

Dai, W; Shi, Y; Cai, L

1995-03-01

91

Different DNA damage and cell cycle checkpoint control in low- and high-risk human papillomavirus infections of the vulva.  

PubMed

Human papillomavirus (HPV) infections may result in benign hyperplasia, caused by low-risk HPV types, or (pre)malignant lesions caused by high-risk HPV types. The molecular basis of this difference in malignant potential is not completely understood. Here, we performed gene profiling of different HPV infected vulvar tissues (condylomata acuminata (n = 5), usual type vulvar intraepithelial neoplasia (uVIN) (n = 9)) and control samples (n = 14) using Affymetrix Human U133A plus 2 GeneChips. Data were analyzed using OmniViz®, Partek® and Ingenuity® Software. Results were validated by real-time RT-PCR and immunostaining. Although similarities were observed between gene expression profiles of low- and high-risk HPV infected tissues (e.g., absence of estrogen receptor in condylomata and uVIN), high-risk HPV infected tissues showed more proliferation and displayed more DNA damage than tissues infected with low-risk HPV. These observations were confirmed by differential regulation of cell cycle checkpoints and by increased expression of DNA damage-biomarkers p53 and ?H2AX. Furthermore, FANCA, FANCD2, BRCA1 and RAD51, key players in the DNA damage response, were significantly upregulated (p < 0.05). In addition, we compared our results with publicly available gene expression profiles of various other HPV-induced cancers (vulva, cervix and head-and-neck). This showed p16(INK4a) was the most significant marker to detect a high-risk HPV infection, but no other markers could be found. In conclusion, this study provides insight into the molecular basis of low- and high-risk HPV infections and indicates two main pathways (cell cycle and DNA damage response) that are much stronger affected by high-risk HPV as compared to low-risk HPV. PMID:21815142

Santegoets, Lindy A M; van Baars, Romy; Terlou, Annelinde; Heijmans-Antonissen, Claudia; Swagemakers, Sigrid M A; van der Spek, Peter J; Ewing, Patricia C; van Beurden, Marc; van der Meijden, Willem I; Helmerhorst, Theo J M; Blok, Leen J

2012-06-15

92

Paraneoplastic stiff person syndrome associated with colon cancer misdiagnosed as idiopathic Parkinson’s disease worsened after capecitabine therapy  

PubMed Central

Objectives To refresh clinical diagnostic dilemmas in patients presenting with symptoms resembling to those of parkinsonism, to report rare association of colon cancer and paraneoplastic stiff person syndrome (SPS), and to draw attention on the possible correlation of capecitabine therapy with worsening of paraneoplastic SPS. Methods Case report of the patient with paraneoplastic SPS due to colon cancer that was misdiagnosed as idiopathic Parkinson’s disease (iPD), whose symptoms worsened after beginning adjuvant capecitabine chemotherapy. Results We describe a 55-year-old woman with subacute onset of symmetrical stiffness and rigidity of the truncal and proximal lower limb muscles that caused lower body bradykinesia, gait difficulties, and postural instability. Diagnose of iPD was made and levodopa treatment was initiated but failed to provide beneficial effect. Six months later, colon cancer was discovered and the patient underwent surgical procedure and chemotherapy with capecitabine thereafter. Aggravation of stiffness, rigidity, and low back pain was observed after the first chemotherapy cycle and capecitabine was discontinued. Furthermore, levodopa was slowly discontinued and low dose of diazepam was administered which resulted in partial resolution of the patient’s symptoms. Conclusion Paraneoplastic SPS is rare disorder with clinical features resembling those of parkinsonian syndrome and making the correct diagnosis remains a challenge. The diagnosis of parkinsonian syndrome should be re-examined if subsequent examinations discover an associated malignant process. Although it remains unclear whether the patients with history of SPS are at the greater risk for symptoms deterioration after administration of capecitabine, clinicians should be aware of capecitabine side effects because recognition and appropriate management can prevent serious adverse outcomes. PMID:24028681

2013-01-01

93

[Epidermolytic hyperkeratosis of the vulva associated with basal cell carcinoma in a patient with vaginal condyloma acuminatum and vaginal intraepithelial neoplasia harboring HPV, type 42].  

PubMed

The occurrence of basal cell carcinoma (BCC) of the vulva is rare. We report the case of a 79-year-old woman with a medical history of intravaginal condyloma acuminatum and vaginal intraepithelial neoplasia 3 (VaIN 3) who presented with a solitary whitish lesion sized 8x5 mm with a central desquamation located on the right labium majus. Histopathologic examination revealed a typical superficial and nodular BCC. Additionally, there were multiple remarkable foci of epidermolytic hyperkeratosis (EH). These foci both merged with superficial BCC or were sharply demarcated from the tumor. Retrospective molecular-biological examination of all the available material revealed HPV type 42 in both condyloma acuminatum and VaIN 3 specimen but not in the BCC associated with EH. To our best knowledge, involvement of the lower female genitalia by EH is a rare finding with six cases published to date. Awareness of EH in this location and its distinction is important because it may be potentially misinterpreted as a viral condyloma. Keywords: vulva - basal cell carcinoma - epidermolytic hyperkeratosis - human papillomavirus. PMID:24758505

Kacerovská, Denisa; Michal, Michal; Kašpírková, Jana; Kazakov, Dmitry V

2014-04-01

94

A case of dermatofibrosarcoma protuberans of the vulva with a COL1A1/PDGFB fusion identical to a case of giant cell fibroblastoma.  

PubMed

Dermatofibrosarcoma protuberans (DFSP) is a highly recurrent low-grade soft tissue sarcoma, which is usually located on the trunk. Presentation in the vulva is rare, with only 13 cases being reported to date, none of which have been investigated at the cytogenetic or molecular level. Specific cytogenetic abnormalities, involving chromosomes 17 and 22, are characteristic features of DFSP and giant cell fibroblastoma (GCF), a tumor closely related to DFSP. These chromosomal rearrangements result in the fusion of the COL1A1 and PDGFB genes in both lesions and show wide variation in the position of the fusion point in COL1A1. Here, we describe a case of DFSP of the vulva with a typical monotonous storiform pattern, with no foci of multinucleated giant cells. Cytogenetic analysis showed a 47,XX,+r karyotype in 50% of the cells, and molecular investigation disclosed the presence of a transcript fusing COL1A1 exon 37 to PDGFB exon 2. This is the first case of DFSP showing such a fusion point, which is intriguingly identical to that found in a GCF case, indicating that the COL1A1/PDGFB fusion point position does not seem to affect tumor morphology. This finding further underlines the very close relationship between these two morphologically distinct entities. PMID:10963386

Vanni, R; Faa, G; Dettori, T; Melis, G B; Dumanski, J P; O'Brien, K P

2000-07-01

95

Lymphatic Mapping and Sentinel Lymph Node Biopsy in Women With Squamous Cell Carcinoma of the Vulva: A Gynecologic Oncology Group Study  

PubMed Central

Purpose To determine the safety of sentinel lymph node biopsy as a replacement for inguinal femoral lymphadenectomy in selected women with vulvar cancer. Patients and Methods Eligible women had squamous cell carcinoma, at least 1-mm invasion, and tumor size ? 2 cm and ? 6 cm. The primary tumor was limited to the vulva, and there were no groin lymph nodes that were clinically suggestive of cancer. All women underwent intraoperative lymphatic mapping, sentinel lymph node biopsy, and inguinal femoral lymphadenectomy. Histologic ultra staging of the sentinel lymph node was prescribed. Results In all, 452 women underwent the planned procedures, and 418 had at least one sentinel lymph node identified. There were 132 node-positive women, including 11 (8.3%) with false-negative nodes. Twenty-three percent of the true-positive patients were detected by immunohistochemical analysis of the sentinel lymph node. The sensitivity was 91.7% (90% lower confidence bound, 86.7%) and the false-negative predictive value (1-negative predictive value) was 3.7% (90% upper confidence bound, 6.1%). In women with tumor less than 4 cm, the false-negative predictive value was 2.0% (90% upper confidence bound, 4.5%). Conclusion Sentinel lymph node biopsy is a reasonable alternative to inguinal femoral lymphadenectomy in selected women with squamous cell carcinoma of the vulva. PMID:22753905

Levenback, Charles F.; Ali, Shamshad; Coleman, Robert L.; Gold, Michael A.; Fowler, Jeffrey M.; Judson, Patricia L.; Bell, Maria C.; De Geest, Koen; Spirtos, Nick M.; Potkul, Ronald K.; Leitao, Mario M.; Bakkum-Gamez, Jamie N.; Rossi, Emma C.; Lentz, Samuel S.; Burke, James J.; Van Le, Linda; Trimble, Cornelia L.

2012-01-01

96

[Cerebral sparganosis in a child: case report].  

PubMed

We are reporting the case of an 8-year-old boy with history of seizures in whom the pathology exam of 2.5 by 3 cm surgical specimen obtained from a cortical-subcortical area of the de right occipital lobe showed a chronic granulomatous inflammatory process with a Spirometras pp larva. The patient was born and lived several years at a rural area of Tarija (Bolivia). This appears to represent the first reported case of this parasitic infection localized to the brain of a child in Argentina. PMID:23381708

Jones, Marta C; Agosti, María Rosa; D'Agustini, Marcelo; Uriarte, Valeria; Drut, Ricardo

2013-01-01

97

Extranodal natural killer/T-cell lymphoma, nasal type, involving the skin, misdiagnosed as nasosinusitis and a fungal infection: A case report and literature review  

PubMed Central

The present study reports a case of extranodal natural killer (NK)/T-cell lymphoma, nasal type, involving the skin. The clinical manifestations, pathological characteristics, treatment and prognosis of the case were analyzed to improve the clinical diagnosis and treatment for this disease. The patient was a 56-year-old male, presenting with dark red nodules and plaques that had been visible on the nose for half a year. Based on the skin lesions and histopathological and immunohistochemical examination results, the patient was diagnosed with extranodal NK/T-cell lymphoma, nasal type. This disease has unique histopathological and immunohistochemical features and a high malignancy. The condition tends to be misdiagnosed and has a poor prognosis, but seldom involves the skin. In the present case, only radiotherapy was performed, with no relapse occurring within 6 months. PMID:25289105

ZHENG, YAN; JIA, JINJING; LI, WENSHENG; WANG, JUAN; TIAN, QIONG; LI, ZHENGXIAO; YANG, JING; DONG, XINYU; PAN, PING; XIAO, SHENGXIANG

2014-01-01

98

H3K9me2/3 Binding of the MBT Domain Protein LIN-61 Is Essential for Caenorhabditis elegans Vulva Development  

PubMed Central

MBT domain proteins are involved in developmental processes and tumorigenesis. In vitro binding and mutagenesis studies have shown that individual MBT domains within clustered MBT repeat regions bind mono- and dimethylated histone lysine residues with little to no sequence specificity but discriminate against the tri- and unmethylated states. However, the exact function of promiscuous histone methyl-lysine binding in the biology of MBT domain proteins has not been elucidated. Here, we show that the Caenorhabditis elegans four MBT domain protein LIN-61, in contrast to other MBT repeat factors, specifically interacts with histone H3 when methylated on lysine 9, displaying a strong preference for di- and trimethylated states (H3K9me2/3). Although the fourth MBT repeat is implicated in this interaction, H3K9me2/3 binding minimally requires MBT repeats two to four. Further, mutagenesis of residues conserved with other methyl-lysine binding MBT regions in the fourth MBT repeat does not abolish interaction, implicating a distinct binding mode. In vivo, H3K9me2/3 interaction of LIN-61 is required for C. elegans vulva development within the synMuvB pathway. Mutant LIN-61 proteins deficient in H3K9me2/3 binding fail to rescue lin-61 synMuvB function. Also, previously identified point mutant synMuvB alleles are deficient in H3K9me2/3 interaction although these target residues that are outside of the fourth MBT repeat. Interestingly, lin-61 genetically interacts with two other synMuvB genes, hpl-2, an HP1 homologous H3K9me2/3 binding factor, and met-2, a SETDB1 homologous H3K9 methyl transferase (H3K9MT), in determining C. elegans vulva development and fertility. Besides identifying the first sequence specific and di-/trimethylation binding MBT domain protein, our studies imply complex multi-domain regulation of ligand interaction of MBT domains. Our results also introduce a mechanistic link between LIN-61 function and biology, and they establish interplay of the H3K9me2/3 binding proteins, LIN-61 and HPL-2, as well as the H3K9MT MET-2 in distinct developmental pathways. PMID:21437264

Koester-Eiserfunke, Nora; Fischle, Wolfgang

2011-01-01

99

Synovial sarcoma arising in the vulva cytogenetically confirmed by SYT break-apart rearrangement fluorescence in situ hybridization: A case report and discussion of diagnostic methods  

PubMed Central

Synovial sarcoma (SS) is a soft tissue sarcoma of unknown histogenesis that rarely occurs in the female genital tract. We report a case of SS occurring in the right vulva of a young Japanese female. The tumor was composed of poorly differentiated rounded cell areas, surrounded by fibroblastic spindle-shaped cell areas. Immunohistochemically, the tumor cells were focally positive for cytokeratin, vimentin, CD99, Bcl-2 and neuron-specific enolase. The tumor was suspected, but was difficult to confirm as it was an SS based solely on light-microscopic and immunohistochemical findings. Although reverse transcription polymerase chain reaction (RT-PCR) failed to detect SS-specific SYT-SSX fusion gene transcripts using an RNA sample extracted from the formalin-fixed paraffin-embedded tumor tissue, SYT break-apart rearrangement fluorescence in situ hybridization (SYT bar-FISH) successfully confirmed our diagnosis of SS for the tumor. Thus, SYT bar-FISH may be more suitable for the purpose of the molecular diagnosis of SS than conventional RT-PCR when using archival formalin-fixed paraffin-embedded tissue specimens. PMID:23162630

KAWAUCHI, SHIGETO; IHARA, KOICHIRO; NISHIKAWA, KEI; SUGINO, NORIHIRO; TAKAHASHI, MUTSUO; SASAKI1, KOHSUKE

2012-01-01

100

Giant cell angiofibroma misdiagnosed as a vascular malformation and treated with absolute alcohol for one year: a case report and review of the literature  

PubMed Central

Purpose To present the clinical, imaging, pathological and immunohistochemical features of giant cell angiofibroma (GCA). Case presentation In this paper we report an atypical case of a GCA extending from the parotid to the parapharyngeal space. The lesion was being treated as a vascular malformation for one year prior to surgical removal. We summarize the clinical manifestations, imaging, pathological and molecular features of this rare disease. After complete surgical removal of the tumor, immunohistochemical analysis revealed strong positivity for the mesenchymal markers vimentin, CD34, CD31 and CD99 in neoplastic cells. Tumor proliferation antigen marker Ki67 was partly positive (<5% of cells). Tumor cells were negative for muscle-specific actin, epithelial membrane antigen, smooth muscle actin, cytokeratin pan, S100, desmin, glial fibrillary acidic protein, myogenin, MyoD1 and F8. The morphological and immunohistochemical profile was consistent with the diagnosis of GCA. Conclusion GCA is a rare soft tissue tumor that can easily be misdiagnosed in the clinical preoperative setting. In view of the clinical, pathological and molecular features of the tumor, complete surgical removal is the current optimal treatment option, providing accurate diagnosis and low to minimal recurrence rate. PMID:24758544

2014-01-01

101

An AGEF-1/Arf GTPase/AP-1 Ensemble Antagonizes LET-23 EGFR Basolateral Localization and Signaling during C. elegans Vulva Induction  

PubMed Central

LET-23 Epidermal Growth Factor Receptor (EGFR) signaling specifies the vulval cell fates during C. elegans larval development. LET-23 EGFR localization on the basolateral membrane of the vulval precursor cells (VPCs) is required to engage the LIN-3 EGF-like inductive signal. The LIN-2 Cask/LIN-7 Veli/LIN-10 Mint (LIN-2/7/10) complex binds LET-23 EGFR, is required for its basolateral membrane localization, and therefore, vulva induction. Besides the LIN-2/7/10 complex, the trafficking pathways that regulate LET-23 EGFR localization have not been defined. Here we identify vh4, a hypomorphic allele of agef-1, as a strong suppressor of the lin-2 mutant Vulvaless (Vul) phenotype. AGEF-1 is homologous to the mammalian BIG1 and BIG2 Arf GTPase guanine nucleotide exchange factors (GEFs), which regulate secretory traffic between the Trans-Golgi network, endosomes and the plasma membrane via activation of Arf GTPases and recruitment of the AP-1 clathrin adaptor complex. Consistent with a role in trafficking we show that AGEF-1 is required for protein secretion and that AGEF-1 and the AP-1 complex regulate endosome size in coelomocytes. The AP-1 complex has previously been implicated in negative regulation of LET-23 EGFR, however the mechanism was not known. Our genetic data indicate that AGEF-1 is a strong negative regulator of LET-23 EGFR signaling that functions in the VPCs at the level of the receptor. In line with AGEF-1 being an Arf GEF, we identify the ARF-1.2 and ARF-3 GTPases as also negatively regulating signaling. We find that the agef-1(vh4) mutation results in increased LET-23 EGFR on the basolateral membrane in both wild-type and lin-2 mutant animals. Furthermore, unc-101(RNAi), a component of the AP-1 complex, increased LET-23 EGFR on the basolateral membrane in lin-2 and agef-1(vh4); lin-2 mutant animals. Thus, an AGEF-1/Arf GTPase/AP-1 ensemble functions opposite the LIN-2/7/10 complex to antagonize LET-23 EGFR basolateral membrane localization and signaling. PMID:25329472

Skorobogata, Olga; Escobar-Restrepo, Juan M.; Rocheleau, Christian E.

2014-01-01

102

An AGEF-1/Arf GTPase/AP-1 Ensemble Antagonizes LET-23 EGFR Basolateral Localization and Signaling during C. elegans Vulva Induction.  

PubMed

LET-23 Epidermal Growth Factor Receptor (EGFR) signaling specifies the vulval cell fates during C. elegans larval development. LET-23 EGFR localization on the basolateral membrane of the vulval precursor cells (VPCs) is required to engage the LIN-3 EGF-like inductive signal. The LIN-2 Cask/LIN-7 Veli/LIN-10 Mint (LIN-2/7/10) complex binds LET-23 EGFR, is required for its basolateral membrane localization, and therefore, vulva induction. Besides the LIN-2/7/10 complex, the trafficking pathways that regulate LET-23 EGFR localization have not been defined. Here we identify vh4, a hypomorphic allele of agef-1, as a strong suppressor of the lin-2 mutant Vulvaless (Vul) phenotype. AGEF-1 is homologous to the mammalian BIG1 and BIG2 Arf GTPase guanine nucleotide exchange factors (GEFs), which regulate secretory traffic between the Trans-Golgi network, endosomes and the plasma membrane via activation of Arf GTPases and recruitment of the AP-1 clathrin adaptor complex. Consistent with a role in trafficking we show that AGEF-1 is required for protein secretion and that AGEF-1 and the AP-1 complex regulate endosome size in coelomocytes. The AP-1 complex has previously been implicated in negative regulation of LET-23 EGFR, however the mechanism was not known. Our genetic data indicate that AGEF-1 is a strong negative regulator of LET-23 EGFR signaling that functions in the VPCs at the level of the receptor. In line with AGEF-1 being an Arf GEF, we identify the ARF-1.2 and ARF-3 GTPases as also negatively regulating signaling. We find that the agef-1(vh4) mutation results in increased LET-23 EGFR on the basolateral membrane in both wild-type and lin-2 mutant animals. Furthermore, unc-101(RNAi), a component of the AP-1 complex, increased LET-23 EGFR on the basolateral membrane in lin-2 and agef-1(vh4); lin-2 mutant animals. Thus, an AGEF-1/Arf GTPase/AP-1 ensemble functions opposite the LIN-2/7/10 complex to antagonize LET-23 EGFR basolateral membrane localization and signaling. PMID:25329472

Skorobogata, Olga; Escobar-Restrepo, Juan M; Rocheleau, Christian E

2014-10-01

103

[Dermatofibrosarcoma protuberans of the vulva].  

PubMed

Dermatofibrosarcoma protuberans (DFSP) is a locally malignant neoplasm derived from fibrous tissue. Similar picture of such lesions to malignant tumors as well as to benign changes creates a risk of too gentle treatment and consequently of recurrence and malignant transformation of the lesions with possible remote metastases. Therefore accurate diagnosis and aggressive surgical treatment can prevent the recurrence of the tumor. Authors of the study present case report of 49-year-old woman with DFSP of vulvar area. PMID:19172838

Olejek, Anita; Kozak-Darmas, Iwona; Gajewska, Alicja; Gabriel, Andrzej; Zajecki, Wojciech

2008-01-01

104

In squamous cell carcinoma of the vulva, overexpression of p53 is a late event and neither p53 nor mdm2 expression is a useful marker to predict lymph node metastases  

PubMed Central

To offer more tailored treatment to individual patients with squamous cell carcinoma of the vulva, more accurate prediction of lymph node metastases is required. As p53 and mdm2 are genes known to be involved in the development of other tumours, we studied expression of p53 and mdm2 in carcinogenesis of squamous cell carcinoma of the vulva and their clinical relevance. Archival material of 141 T1 and T2 vulvar tumours were used. Of the 141 primary tumours, the corresponding 39 lymph node metastases (LNM) were studied, and in 90 cases the pre-existent epithelia adjacent to the tumour (EAT) and in 14 cases vulvar intraepithelial neoplasia adjacent to the tumour (VIN) was also investigated. Detection of p53 and mdm2 protein was immunohistochemically performed. Scoring categories were: negative (1); weakly positive (2); moderately to markedly positive (3); and markedly positive (4). Overexpression of p53 was seen in 56% of the LNM, 39% of the primary tumours, 21% of the VIN lesions and 0% in the group of EAT. No relation was found between overexpression of p53 in the primary tumour and LNM. Expression of mdm2 was seen in 14% of the primary tumours, of which four cases were marked positive. In the group of LNM no mdm2-positive staining was observed. In the group of EAT, 25% was mdm2-positive, of which six cases were marked positive. In the group of VIN, 36% showed moderate (score 3) mdm2 expression. No relation was found between expression of mdm2 and LNM. In squamous cell carcinoma, overexpression of p53 is a late event in carcinogenesis. Marked expression of mdm2 is rarely seen in vulvar carcinomas, indicating that aberrant p53 cannot induce mdm2 expression. LNM cannot be predicted by detection of these proteins. © 1999 Cancer Research Campaign PMID:10389975

Emanuels, A G; Koudstaal, J; Burger, M P M; Hollema, H

1999-01-01

105

Sustained antiproliferative mechanisms by RB24, a targeted precursor of multiple inhibitors of epidermal growth factor receptor and a DNA alkylating agent in the A431 epidermal carcinoma of the vulva cell line  

PubMed Central

Recently, with the purpose of enhancing the potency of epidermal growth factor receptor (EGFR)-based therapies, we designed a novel strategy termed ‘Cascade-release targeting’ that seeks to develop molecules capable of degrading to multiple tyrosine kinase (TK) inhibitors and highly reactive electrophiles, in a stepwise fashion. Here we report on the first prototype of this model, RB24, a masked methyltriazene, that in addition to being an inhibitor on its own was designed to degrade to RB14, ZR08, RB10+a DNA alkylating methyldiazonium species. The cascade degradation of RB24 requires the generation of two reactive electrophiles: (a) an iminium ion and (b) a methyldiazonium ion. Thus, we surmise that these species could alkylate the active site of EGFR, thereby irreversibly blocking its action and that DNA damage could be induced by the methyldiazonium. Using the EGFR-overexpressing human epidermoid carcinoma of the vulva cell line, A431, we demonstrate herein that (a) RB24 and its derived species (e.g. RB14, ZR08) irreversibly inhibit EGFR autophosphorylation, (b) RB24 induced significant levels of DNA strand breaks, (c) sustained inhibition of EGFR by RB24 was associated with blockade of MAPK activation and c-fos gene expression, (d) RB24 induced irreversible cell growth inhibition with a 100-fold greater potency than Temodal™, a clinical methyltriazene. The pronounced growth inhibitory potency of RB24 was attributed to its ability to simultaneously damage DNA and irreversibly block EGFR TK activity. PMID:15365562

Banerjee, R; Rachid, Z; Qiu, Q; McNamee, J P; Tari, A M; Jean-Claude, B J

2004-01-01

106

Sparganosis in Russell's viper snake: a case report.  

PubMed

The occurrence of the plerocercoid larva, Sparganum of Sparganum spp. in two Russell's viper snakes maintained in Chennai snake park trust, Chennai is reported for the first time from Southern India. The cestode larvae were found in the sub cutis and were flat, solid, wrinkled, ribbon like creamy white in colour with peudosegmentation with anterior end possessing bothria. The cuticles, subcuticular cells and parenchymatous tissue stained by acetic alum carmine further confirmed the cestode larvae. PMID:25320490

Kavitha, K T; Latha, B R; Bino Sundar, S T; Sridhar, R; Abdul Basith, S

2014-12-01

107

Feminization and reduction of testicular weight in mouse sparganosis  

PubMed Central

After infection of male mice with the plerocercoids (spargana) of Spirometra mansoni, serum levels of estrogen and testicular weight were analyzed by enzyme-linked immunosorbent assay (ELISA) and weighing machine, respectively. The serum level of estrogen increased progressively in infected mice compared with normal controls, whereas the testicular weight of infected mice decreased significantly (P < 0.05). These results suggest that certain substances from spargana change the steroid hormone metabolisms in the host by unknown pathways, and chronic infection may contribute to change of the function of steroid hormone target organ, i.e., testis, in male mice. PMID:16809967

2006-01-01

108

[Ocular sparganosis in the Czech Republic--a case report].  

PubMed

The authors report a case of 14-year-old boy presented to the Ophthalmologic Department of University Hospital in Olomouc with the diagnosis af acute anterior uveitis. A living parasite has been detected in the anterior chamber in a slit lamp examination. The vitreous and retina remained uninvolved. The acute iridocyclitis associated with parasitic infection is a very rare cause of anterior uveitis in Central Europe. The patient underwent surgical removal of the parasite via paracentesis. The inflammation resolved under the treatment with atropine and dexamethasone drops within a few days. Histopathological examination revealed the parasite as a young larval stage of tapeworm from family Pseudophyllidea (sparganum). Based on the analysis of development cycles of different types of tapeworms and according the literature data on tapeworms found in the Czech Republic genus Spirometra seemed to be the most plausible cause of the patient's disease. As the most probable source of viable parasites authors suspect swallowed water containing tiny infected crustaceans in the dam near the town Olomouc in Moravia. PMID:16958022

Rehák, M; Kolárová, L; Kohnová, I; Rehák, J; Mohlerová, S; Fric, E; Chrapek, O

2006-08-01

109

Completion thyroidectomy for initially misdiagnosed thyroid cancer  

Microsoft Academic Search

Intraoperative frozen sections fails to diagnose thyroid carcinoma accurately in 16% of cases. In such instances, we recommend that completion thyroidectomy be performed in the patient who has invasive carcinoma, is less than 70 years old, and has a reasonable life expectancy. The procedure should be carried out immediately if the error in diagnosis is discovered within a week; otherwise

L. J. Auguste; J. N. Attie

1990-01-01

110

Cerebral Vein Thrombosis Misdiagnosed and Mismanaged  

PubMed Central

Cerebral venous thrombosis (CVT) should be considered in the differential diagnosis of all unexplained CNS disorders of sudden onset. Etiological factors are often subclinical forms of several common thrombophilic states occurring together, rather than the typical inherited and rare causes. Diagnosis is missed because of the heterogeneity in clinical presentation and etiological factors. In several patients with the so called idiopathic CVT nutritional deficiencies and lifestyle issues are more important factors in pathogenesis, rather than single rarer causes. High index of suspicion is the key to diagnosis. Clinical skill has to be fine tuned to diagnose the problem and to identify all the etiological factors. Radiology is essential for diagnosis but relying on radiology alone will lead to missing several cases and even erroneous diagnosis. It is inappropriate to proceed prematurely to laboratory investigations, forgetting proper clinical evaluation by studying diet, lifestyle, and environment of the patients. Success in managing lies in identifying all the contributory causes and correcting all of them giving excellent outcome almost always. Clinical observations based on case series and sharing of such information alone are the means to arrive at a consensus in diagnosis and management. PMID:22567255

Sasidharan, P. K.

2012-01-01

111

Symptomatic Morgagni Hernia Misdiagnosed As Chilaiditi Syndrome  

PubMed Central

Chilaiditi syndrome, symptomatic interposition of bowel beneath the right hemidiaphragm, is uncommon and usually managed without surgery. Morgagni hernia is an uncommon diaphragmatic hernia that generally requires surgery. In this case a patient with a longstanding diagnosis of bowel interposition (Chilaiditi sign) presented with presumed Chilaiditi syndrome. Abdominal computed tomography was performed and revealed no bowel interposition; instead, a Morgagni hernia was found and surgically repaired. Review of the literature did not reveal similar misdiagnosis or recommendations for advanced imaging in patients with Chilaiditi sign or syndrome to confirm the diagnosis or rule out other potential diagnoses. PMID:21691487

Vallee, Phyllis A.

2011-01-01

112

AML M7 Misdiagnosed as ALL.  

PubMed

Hematogones, which are normal precursors of B lymphocytes in the bone marrow, may be mistaken for blast cells on flow cytometry and histology when their numbers increase. We report such a case in a 16 months old male who was unsuccessfully treated for a pre-B cell ALL on the basis of flow cytometry of the bone marrow which showed a substantial population of CD19 and CD10 expressing 'blast' cells. A diagnosis of AML M7 was made on a subsequent bone marrow biopsy in which the blast cells expressed CD61 and Factor VIII, while they were negative for CD10 and CD20. Also present were a few CD10 and CD20 expressing small lymphoid cells, which were interpreted as hematogones. This report reiterates the problem of mistaking hematogones for 'blast' cells on flow cytometry, especially in the marrow of very young children where hematogones are often prominent. PMID:25332577

Chaudhari, Jayashri; Borges, Antia; Bansal, Shweta; Mahajan, Pravin

2014-09-01

113

Leiomyoma in Vulva: A Diagnostic Dilemma  

PubMed Central

With the help of this case we summarize some crucial features to be picked up from history and examination before labeling a case as Bartholin's abscess or cyst. A 20-year old unmarried girl, deaf and mute since birth, was initially diagnosed to have Bartholin's abscess. On careful reexamination after inflammation subsided, a decision of excision of this tumor was taken. Intraoperatively it was found to be well encapsulated. Histopathology ascertained the diagnosis of vulval leiomyoma. PMID:24660079

Shetty, Jyothi; Srilatha, P. S.

2014-01-01

114

Leiomyoma in vulva: a diagnostic dilemma.  

PubMed

With the help of this case we summarize some crucial features to be picked up from history and examination before labeling a case as Bartholin's abscess or cyst. A 20-year old unmarried girl, deaf and mute since birth, was initially diagnosed to have Bartholin's abscess. On careful reexamination after inflammation subsided, a decision of excision of this tumor was taken. Intraoperatively it was found to be well encapsulated. Histopathology ascertained the diagnosis of vulval leiomyoma. PMID:24660079

Pandey, Deeksha; Shetty, Jyothi; Saxena, Aashish; Srilatha, P S

2014-01-01

115

Surgery for Cancer of the Vulva (Vulvectomy)  

MedlinePLUS

... with grief and loss Rebuilding self-esteem Good communication: The key to building a successful sexual relationship Overcoming anxiety about sex Rekindling sexual interest Sexual activity with ... to top »

116

Unique dermatologic aspects of the postmenopausal vulva.  

PubMed

Aging and estrogen deficiency compromise the skin barrier's defense mechanisms, resulting in greater microbial colonization of the skin. Susceptibility to mechanical injury and chemical irritation also increases. Menopause blunts the cell-mediated immune response to microbes and allergens. Healing after an insult is delayed. Skin disorders such as lichen sclerosus or allergic dermatitis may not be clinically obvious. A biopsy interpreted by a dermatopathologist is often helpful. Some conditions require long-term use of topical steroid ointments, and antimicrobial therapy. A compounding pharmacist may be necessary to find a base for the topical cream that does not irritate. PMID:17762422

Summers, Paul R; Hunn, Jessica

2007-09-01

117

Cutaneous basal cell carcinoma of vulva.  

PubMed

Eleven cases of basal cell carcinoma of the vulvar skin are reported. There was fairly close correlation between the histologic type and the gross appearance of the lesion. The average age of the patients was 59 years, and the presenting complaint was usually that of a nodule with associated irritation or pruritus. All patients were treated surgically and none have had recurrent or metastatic disease; six patients have been followed for 12 to 25 years. The treatment of choice is wide local excision. One tumor was of particular interest in that it represented a carcinomatous change in a pre-existing premalignant fibroepithelial tumor. Basal cell carcinoma of the skin must be distinguished from adenoid cystic (basal cell) carcinoma of vestibular glands, which is a more aggressive neoplasm and which metastasizes by the lymphatic and blood vascular systems. PMID:1192371

Cruz-Jimenez, P R; Abell, M R

1975-11-01

118

Vulval dermatoses  

Microsoft Academic Search

Vulval dermatoses are common and can cause significant symptoms. Any generalized skin disorder may affect the anogenital area, but the most common are eczema and psoriasis. Other dermatoses preferentially affect the vulva (e.g. lichen sclerosus, lichen planus). Itching and soreness are the most common symptoms. Many women are not examined and are misdiagnosed with ‘thrush’. Self-treatment with topical medications may

EK Derrick; Sallie Neill

2005-01-01

119

Congenital chloride diarrhea misdiagnosed as pseudo-Bartter syndrome  

PubMed Central

Congenital chloride diarrhea (CCD) is a rare autosomal recessive disease which is characterized by intractable diarrhea of infancy, failure to thrive, high fecal chloride, hypochloremia, hypokalemia, hyponatremia and metabolic alkalosis. In this case report, we present the first female and the second official case of CCD in Iran. A 15-month-old girl referred to our hospital due to failure to thrive and poor feeding. She had normal kidneys, liver and spleen. Treating her with Shohl's solution, thiazide and zinc sulfate did not result in weight gain. Consequently, pseudo-Bartter syndrome was suspected, she was treated with intravenous (IV) therapy to which she responded dramatically. In addition, hypokalemia resolved quickly. Since this does not usually happen in patients with the pseudo-Bartter syndrome, stool tests were performed. Abnormal level of chloride in stool suggested CCD and she was thus treated with IV fluid replacement, Total parentral nutrition and high dose of oral omeprazole (3 mg/kg/day). She gained 1 kg of weight and is doing fine until present. CCD is a rare hereditary cause of intractable diarrhea of infancy. It should be considered in infants with unknown severe electrolyte disturbances. PMID:24381629

Saneian, Hossein; Bahraminia, Emad

2013-01-01

120

Congenital chloride diarrhea misdiagnosed as pseudo-Bartter syndrome.  

PubMed

Congenital chloride diarrhea (CCD) is a rare autosomal recessive disease which is characterized by intractable diarrhea of infancy, failure to thrive, high fecal chloride, hypochloremia, hypokalemia, hyponatremia and metabolic alkalosis. In this case report, we present the first female and the second official case of CCD in Iran. A 15-month-old girl referred to our hospital due to failure to thrive and poor feeding. She had normal kidneys, liver and spleen. Treating her with Shohl's solution, thiazide and zinc sulfate did not result in weight gain. Consequently, pseudo-Bartter syndrome was suspected, she was treated with intravenous (IV) therapy to which she responded dramatically. In addition, hypokalemia resolved quickly. Since this does not usually happen in patients with the pseudo-Bartter syndrome, stool tests were performed. Abnormal level of chloride in stool suggested CCD and she was thus treated with IV fluid replacement, Total parentral nutrition and high dose of oral omeprazole (3 mg/kg/day). She gained 1 kg of weight and is doing fine until present. CCD is a rare hereditary cause of intractable diarrhea of infancy. It should be considered in infants with unknown severe electrolyte disturbances. PMID:24381629

Saneian, Hossein; Bahraminia, Emad

2013-09-01

121

“Osler’s phenomenon”: misdiagnosing Cushing’s syndrome  

Microsoft Academic Search

The clinical manifestations of Cushing’s syndrome can be quite variable and are frequently mistaken, with consequent delayed diagnosis and significant morbidity and mortality. Harvey Cushing described the typical signs and symptoms of Cushing’s syndrome but unfortunately attributed the features to myxoedema. The first typical description of a patient with Cushing’s syndrome was probably made by Sir William Osler in 1898.

P De; L M Evans; M F Scanlon; J S Davies

2003-01-01

122

Peroneal neuropathy misdiagnosed as L5 radiculopathy: a case report  

PubMed Central

Objective The purpose of this case report is to describe a patient who presented with a case of peroneal neuropathy that was originally diagnosed and treated as a L5 radiculopathy. Clinical features A 53-year old female registered nurse presented to a private chiropractic practice with complaints of left lateral leg pain. Three months earlier she underwent elective left L5 decompression surgery without relief of symptoms. Intervention and outcome Lumbar spine MRI seven months prior to lumbar decompression surgery revealed left neural foraminal stenosis at L5-S1. The patient symptoms resolved after she stopped crossing her legs. Conclusion This report discusses a case of undiagnosed peroneal neuropathy that underwent lumbar decompression surgery for a L5 radiculopathy. This case study demonstrates the importance of a thorough clinical examination and decision making that ensures proper patient diagnosis and management. PMID:23618508

2013-01-01

123

Case of lepromatous leprosy misdiagnosed as systemic sclerosis.  

PubMed

Hansen's disease (HD) is a chronic granulomatous infectious disease caused by Mycobacterium leprae. The worldwide prevalence rate of HD has decreased gradually over the years. The clinical manifestations of HD are extensive, with involvement of the skin and various organs, and these can resemble those of many rheumatic diseases. Our patient initially presented with gradual sclerotic skin change and slight sclerodactyly with Raynaud's phenomenon, which is frequently observed in systemic sclerosis. However, a skin biopsy with acid-fast stain later confirmed lepromatous leprosy. We report this case to emphasize the role of dermatologists for applying a systematic approach to the skin lesions of HD, which has become difficult to detect because of its rapidly declining prevalence rate. PMID:24480058

Lee, Jin Yong; Park, So Eun; Shin, Soo Jung; Kim, Chul Woo; Kim, Sang Seok

2014-04-01

124

Melanocytoma of the ciliary body misdiagnosed as iridodialysis.  

PubMed

A 62-year-old female presented to our institution with dimness of vision in her right eye. On examination, her best corrected visual acuity was 20/100 in the right eye. The intraocular pressures were 14 mmHg in both eyes. Slit-lamp examination revealed nuclear sclerotic cataracts bilaterally and iridodialysis in her right eye. Seven days after the first visit, cataract surgery was performed without any complications. One year later, she presented to our institution with acute visual loss and ocular pain in the right eye. Best corrected visual acuity of the right eye was light perception and the intraocular pressure was 44 mmHg. Slit-lamp examination revealed a ciliary body mass with widespread pigment dispersion in the anterior segment. Due to no useful vision and uncontrolled pain, enucleation of the right eye was performed. Histopathologic examination revealed a melanocytoma of the ciliary body. PMID:24926192

Kim, Moosang; Lee, Seung-Jun

2014-01-01

125

Dermatofibrosarcoma protuberans of the vulva: a case report  

PubMed Central

Dermatofibrosarcoma protuberans (DFSP) is a low-grade to intermediate-grade well-differentiated sarcoma of dermal origin. Local recurrence rates are high but distant metastases are rare. This report describes a case of vulvar DFSP requiring four resections for primary clearance. A 56-year-old woman referred after excision of a vulvar tumour and histology had DFSP extending to the resection margins. Two more extended excisions again yielded a specimen with positive margins. The last excision was performed with intraoperative frozen section analysis of the margins. Frozen section analysis of the resected specimen revealed clear margins and this was confirmed by final pathology. The postoperative course was uneventful. The patient has been without recurrence for 15 months. A wide and deep local excision is recommended for both primary and recurrent lesions. The patient had three resections before clear surgical margins were achieved. Intraoperative frozen section analysis is helpful in assessing resection margins. PMID:21686834

Oge, Tufan; Benedicic, Christoph; Tamussino, Karl; Regauer, Sigrid

2009-01-01

126

Dermatofibrosarcoma protuberans of the vulva: a case report.  

PubMed

Dermatofibrosarcoma protuberans (DFSP) is a low-grade to intermediate-grade well-differentiated sarcoma of dermal origin. Local recurrence rates are high but distant metastases are rare. This report describes a case of vulvar DFSP requiring four resections for primary clearance. A 56-year-old woman referred after excision of a vulvar tumour and histology had DFSP extending to the resection margins. Two more extended excisions again yielded a specimen with positive margins. The last excision was performed with intraoperative frozen section analysis of the margins. Frozen section analysis of the resected specimen revealed clear margins and this was confirmed by final pathology. The postoperative course was uneventful. The patient has been without recurrence for 15 months. A wide and deep local excision is recommended for both primary and recurrent lesions. The patient had three resections before clear surgical margins were achieved. Intraoperative frozen section analysis is helpful in assessing resection margins. PMID:21686834

Oge, Tufan; Benedicic, Christoph; Tamussino, Karl; Regauer, Sigrid

2009-01-01

127

Vulvar Dermatoses – Irritant and Allergic Contact Dermatitis of the Vulva  

Microsoft Academic Search

Irritant and allergic contact dermatitis are commonly seen in patients complaining about itching, burning and irritation in the vulvar area. Irritation often precedes allergic sensitization. Clinically, irritant and allergic contact dermatitis can be difficult to distinguish. Diagnosis is made by history, clinical investigation and patch testing. Recommended patch test series are the standard series, a medicament series, the patient’s own

A. Bauer; C. Rödiger; C. Greif; M. Kaatz; P. Elsner

2005-01-01

128

MRSA infection of buttocks, vulva, and genital tract in women  

Microsoft Academic Search

Staphylococcus aureus, although a common commensal bacterium, is a frequent cause of skin and soft tissue infections as well as life-threatening\\u000a blood stream infections. Resistance to methicillin, which previously was associated with only hospitalized patients, has become\\u000a a common community-based phenomenon. Less well known is S. aureus vaginal colonization and heterosexual transmission, mainly by skin-mucosa contact. Recognizing the vagina as

Orna Reichman; Jack D. Sobel

2009-01-01

129

Cancer of the Vulva - SEER Stat Fact Sheets  

Cancer.gov

SEER is an authoritative source of information on cancer incidence and survival in the United States. SEER currently collects and publishes cancer incidence and survival data from population-based cancer registries covering approximately 28 percent of the U.S. population.

130

Aggressive angiomyxoma of the vulva: A case report  

PubMed Central

Aggressive angiomyxoma (AA) is an unusual mesenchymal tumor. AA occurs most commonly in women of reproductive age and is located in the perineal or pelvic region. This is a distinct soft tissue tumor that has a prominent myxoid matrix and numerous thin-walled blood vessels and may have an aggressive local recurrence. The tumors have the characteristics of large size (usually greater than 10 cm) and slow growth, and are not painful. The standard treatment for AA is total excision and close follow-up. We announce a case of a 35 year-old female presenting with a pedunculated AA on the right labium majora that has not relapsed for seven years. PMID:24678492

Lee, Kyoung-A; Seo, Jung-Won; Yoon, Na-Ra; Kim, Byoung-Gie; Bae, Duk-Soo

2014-01-01

131

Recurrent Aggressive Angiomyxoma of The Vulva - A Rare Presentation  

PubMed Central

We describe here a case of a 38-year-old lady presenting with a about 5x4cm in size swelling on the left labia majora. She had similar type of swelling 2 years back which was treated surgically. FNAC report of the present mass revealed angiomyxoma. In view of its’ recurrent nature wide local surgical excision of the mass was done. Histopathology report confirmed the diagnosis of angiomyxoma. The lady is under follow up and there is no further recurrence till date. PMID:24995218

Sengupta, Sandip Kumar; Bhattacharyya, Sanjay Kumar; Saha, Shyama Prasad; Sarkar, Amarendra Nath

2014-01-01

132

Cellular schwannoma arising from the gastric wall misdiagnosed as a gastric stromal tumor: A case report  

PubMed Central

Cellular schwannomas have been previously described at almost every anatomic location of the human body, but reports in the gastric wall are rare. The current study presents a rare case of cellular schwannoma originating from the gastric wall. Computed tomography revealed a 5.6×5.3×4.0-cm3 solid mass located in the posterior wall of the stomach. Open laparotomy confirmed its mesenchymal origin. Microscopically, the tissue was composed of spindle-shaped and fascicularly-arranged cells, but mitotic figures were rare. Immunohistochemical staining showed that the tumor was negative for cluster of differentiation (CD)117, CD34, smooth muscle actin and desmin, but positive for S-100 and Ki67. The patient presented no evidence of recurrence and metastasis during follow-up. Gastric cellular schwannomas may be diagnosed by clinical characteristics, histological observations and immunohistochemical markers. PMID:24396458

WANG, GUANGYAO; CHEN, PING; ZONG, LIANG; SHI, LEI; ZHAO, WEI

2014-01-01

133

A case of galactosemia misdiagnosed as cow’s milk intolerance  

PubMed Central

We report on a female patient affected by galactosemia in whom the diagnosis was obscured by the concomitant presence of manifestations suggesting a cow’s milk intolerance. This case exemplifies the problems in reaching a correct diagnosis in patients with metabolic diseases. PMID:22992216

2012-01-01

134

Solid Pseudopapillary Tumor of the Pancreas: a rare and probably misdiagnosed neoplasm  

PubMed Central

Solid Pseudopapillary Tumor of the pancreas is a rare nonfunctioning tumor. It is considered a low-grade malignancy that is apparently curable with surgical complete excision in most instances. We present a case of solid pseudopapillary pancreatic tumor that represented a challenge to the radiologists. This case highlights its possible various appearances and the need to the radiologist to be familiar with them. PMID:22470804

Vilaca, Ana Frias; Rodrigues, Pedro; Scigliano, Horacio; Pinto, Joana; Reis, Alcinda

2011-01-01

135

[Misdiagnosed rupture of the diaphragm following blunt thoracic-abdominal trauma].  

PubMed

The histories of 67 patients with a diaphragmatic rupture due to blunt trauma were reviewed in four hospitals. In 45 patients the diagnosis was made within 24 hours after the accident, in the other 22 patients the rupture was diagnosed in a later stage. In the first group there were much abdominal injuries and during emergency laparotomy for some other reasons in 29% of these cases the diaphragmatic rupture was found accidentally. Not recognizing a rupture in the acute phase and therefore delaying operation was caused by the fact that the initial chest X-ray was not thoroughly checked for signs of a diaphragmatic rupture. The reasons for operation in the "delayed" group were mainly typical abnormalities for diaphragmatic rupture of the chest X-rays and other investigations proving the diagnosis. Only in one patient the delay in diagnosis has led to a very serious complication: because of incarceration with gangrene of a part of the small bowel it was necessary to remove this part. The other 21 patients in the group where the diagnosis was initially missed did not suffer from any serious complication. PMID:3424459

van Loenhout, R M; Carol, E J; Lubbers, E J; Reinders, J F; van der Werken, C

1987-10-01

136

Delayed Surgery for Parathyroid Adenoma Misdiagnosed as a Thyroid Nodule and Treated with Radiofrequency Ablation  

PubMed Central

Primary hyperparathyroidism occurs as a result of isolated parathyroid adenoma in 80% to 85% of all cases. A 99mtechnetium (99mTc) sestamibi scan or neck ultrasonography is used to localize the neoplasm prior to surgical intervention. A 53-year-old female was referred for the exclusion of metabolic bone disease. She presented with low back pain that had persisted for the past 6 months and elevated serum alkaline phosphatase (1,253 IU/L). Four years previously, she had been diagnosed at a local hospital with a 2.3-cm thyroid nodule, which was determined to be pathologically benign. Radiofrequency ablation was performed at the same hospital because the nodule was still growing during the follow-up period 2 years before the visit to our hospital, and the procedure was unsuccessful in reducing the size of the nodule. The results of the laboratory tests in our hospital were as follows: serum calcium, 14.6 mg/dL; phosphorus, 3.5 mg/dL; and intact parathyroid hormone (iPTH), 1,911 pg/mL. Neck ultrasonography and 99mTc sestamibi scan detected a 5-cm parathyroid neoplasm in the left lower lobe of the patient's thyroid; left parathyroidectomy was performed. This case indicated that thyroid ultrasonographers and pathologists need to be experienced enough to differentiate a parathyroid neoplasm from a thyroid nodule; 99mTc sestamibi scan, serum calcium, and iPTH levels can help to establish the diagnosis of parathyroid neoplasm. PMID:24396684

Kim, Ho-Su; Choi, Bong Hoi; Park, Jung Rang; Hahm, Jong Ryeal; Jung, Jung Hwa; Kim, Soo Kyoung; Kim, Sungsu; Kim, Kyong-Young; Chung, Soon Il

2013-01-01

137

Abdominal imaging can misdiagnose submassive hepatic necrosis as cirrhosis in acute liver failure.  

PubMed

Patients with acute liver failure (ALF) can be listed status I for liver transplantation (LT) whereas patients with cirrhosis must follow the MELD scoring system. Liver imaging can mistakenly diagnose submassive hepatic necrosis in ALF as cirrhosis. The purpose of our study was to assess the accuracy of ultrasound (US) and computed tomography (CT) in distinguishing cirrhosis from ALF. All patients listed for ALF and transplanted during the study period were included. Controls were age- and gender-matched cirrhotic patients who underwent LT during the same period. Abdominal US or CT scans obtained on all patients were independently reviewed by three blinded abdominal radiologists. Explants from all patients were reviewed by two blinded pathologists, and histological diagnosis was correlated with radiological diagnosis. Forty-one patients with ALF and 42 patients with cirrhosis were analyzed. Univariate and multivariate analyses both revealed overall accuracy of 85% for ultrasound and 93% for CT. US and CT scans both provide high levels of accuracy in terms of discriminating ALF from cirrhosis but measures taken to determine whether a patient has ALF vs. cirrhosis needs to approach 100% accuracy. Thus, imaging studies alone should not definitively diagnosis one etiology of liver failure over the other. PMID:23647426

Kim, Andrew I; Han, Steven-Huy; Tran, Doan-Trang; Sullivan, Peggy; Lassman, Charles; Raman, Steve; Zimmerman, Peter; Chin, Eva E

2013-01-01

138

Granuloma induced by sustained-release fluorouracil implants misdiagnosed as a hepatic tumor: A case report  

PubMed Central

Sustained-release fluorouracil (FU) implants have been extensively used in peritoneal interstitial chemotherapy, and during surgery for gastrointestinal tumors, breast cancer and hepatic tumors. Currently, studies regarding the complications associated with sustained-release FU implants are rare. The present study describes the case of a 61-year-old male who presented with a space-occupying lesion of the left lobe of the liver six months after undergoing a radical total gastrectomy. Thus, laparoscopic exploration was performed to remove the tumor. Postoperative histological examination demonstrated that the lesion in the left lobe comprised of necrotic tissue with granulation tissue hyperplasia. Based on the surgical and postoperative histological findings, the mass was proposed to be due to a high concentration of local sustained-release FU implants. Furthermore, the drug was partially surrounded and had been insufficiently metabolized over a long time period, which was proposed to have caused necrosis, proliferation and fibrillation, and induced granuloma. In conclusion, local high concentrations of sustained-release FU implants may be associated with granuloma and this finding may enable improved management of sustained-release FU implants during surgery. PMID:25013494

BAI, DOU-SHENG; JIN, SHENG-JIE; HE, RONG; JIANG, GUO-QING; YAO, JIE

2014-01-01

139

Persistent Genital Arousal Disorder Misdiagnosed Due to Islamic Religious Bathing Rituals: A Report of 3 Cases  

Microsoft Academic Search

Persistent genital arousal disorder (PGAD) is not well known or adequately understood by physicians. PGAD is characterized by a persistent and highly unwanted state of genital arousal and orgasm-like feelings. “Ghusl” is an ablution in Islamic culture, which is an obligatory ritual wherein the body is washed thoroughly after exposure to “religious contaminants,” such as sexual intercourse, menstruation, and childbirth.

Ejder Akgun Yildirim; Munevver Hacioglu; Altan Essizoglu; Ilker Kucukparlak

2012-01-01

140

Persistent Genital Arousal Disorder Misdiagnosed Because of Islamic Religious Bathing Rituals: A Report of Three Cases  

Microsoft Academic Search

Persistent genital arousal disorder is not well known or adequately understood by physicians. The disorder is characterized by a persistent and highly unwanted state of genital arousal and orgasm-like feelings. Ghusl is an ablution in Islamic culture, which is an obligatory ritual wherein the body is washed thoroughly after exposure to religious contaminants such as sexual intercourse, menstruation, and childbirth.

Ejder Akgun Yildirim; Munevver Hacioglu; Altan Essizoglu; Ilker Kucukparlak

2012-01-01

141

A Case of Misdiagnosed Cesarean Scar Pregnancy with a Viable Birth at 28 Weeks  

PubMed Central

We report our experience with a case of presumptive cesarean scar pregnancy, based on detection of a gestational sac (GS) in early pregnancy at the site of a previous cesarean scar. The GS grew into the uterine cavity as the pregnancy progressed, showing an ultrasound image similar to that of a normal pregnancy. Thus, the pregnancy continued, resulting in a viable birth at 28 weeks of gestation. Cesarean scar pregnancy is classified as myometrial implantation or implantation growth into the uterine cavity. In the latter type, the gestational sac moves upward with increasing gestational weeks and it shows the same ultrasound image as a normal pregnancy. Therefore, the diagnosis must be made in the early pregnancy. PMID:25371837

Nukaga, Sakiko; Aoki, Shigeru; Kurasawa, Kentaro; Takahashi, Tsuneo; Hirahara, Fumiki

2014-01-01

142

Interstitial granulomatous dermatitis: a misdiagnosed cutaneous form of systemic lupus erythematosus?  

PubMed

Interstitial granulomatous dermatitis (IGD) is a recently described, rare dermatological entity. The clinical features are diverse and the precise aetiology is unknown. We present a rare and atypical case of IGD in a patient with systemic lupus erythematosus (SLE). A 26-year-old woman had been diagnosed with SLE when she was 15 years old. The diagnosis was based on cutaneous, articular, pulmonary, haematological and immunological features. The patient presented with a cutaneous diffuse macular eruption on the limbs, appearing in a cockade (rosette) pattern with a violaceous centre and erythematous surround. The face and trunk were spared. The cutaneous histological features led us to consider a diagnosis of IGD. The lesions disappeared after 15 days of systemic steroid therapy. This case is a new clinical form of IGD with an atypical location and clinical presentation. IGD has usually been associated with drug-related adverse reactions and autoimmune diseases. Reports in the literature of IGD in patients with SLE are rare. PMID:18681887

Blaise, S; Salameire, D; Carpentier, P H

2008-11-01

143

Mucinous cystadenoma of the appendix misdiagnosed as cystic hydatid disease of the liver: a case report  

PubMed Central

Introduction Primary neoplastic lesions presenting with a mucocele of the appendix are very rare and can be divided into benign variants of mucinous adenomas or cystadenomas, mucinous tumours of uncertain malignant potential or mucinous cystadenocarcinomas. Most of these tumourous mucoceles are asymptomatic and are found incidentally. The major complication of neoplastic mucinous appendiceal tumours is the development of a pseudomyxoma peritonei due to spreading of mucin-producing cells within the abdominal cavity. Case presentation A 44-year-old man presented with a history of non-specific symptoms of right upper abdominal pain. Abdominal ultrasound and computed tomography scan identified a cystic mass consistent with the morphological characteristics of an echinococcal hydatid cyst. After completing systemic albendazole therapy, an explorative laparotomy revealed a cystic tumour of the appendix. Ileocaecal resection was performed and pathology reports confirmed the diagnosis of a mucinous cystadenoma of the appendix. The postoperative course was uneventful. Conclusion Here we present the case of a man with a mucinous cystadenoma of the appendix mimicking cystic hydatid disease. We discuss the importance of re-evaluation and differential diagnostic reflections in cases of appendiceal mucocele. PMID:18578871

Krieg, Andreas; Esch, Jan Schulte am; Poll, Ludger W; Braunstein, Stefan; Knoefel, Wolfram T

2008-01-01

144

A Common Medical Error: Lung Cancer Misdiagnosed as Sputum Negative Tuberculosis  

Microsoft Academic Search

Objective: To emphasize that delay in diagnosis of lung cancer can be caused by the wrong diagnosis of tuberculosis (TB) in TB endemic countries. This is of major concern as early-diagnosis of lung cancer can increase the chance of tumor resectability and timely chemo-radiotherapy may provide better quality of life. Methods: Proven lung cancer patients, who had received anti-tubercular treatment

Vikas Kumar Singh; Subhash Chandra; Sachin Kumar; Ghanshyam Pangtey; Anant Mohan; Randeep Guleria

2009-01-01

145

Primary Malignant Fibrous Histiocytoma of the Chest Wall Misdiagnosed as Traumatic Hemothorax  

PubMed Central

Malignant fibrous histiocytoma (MFH), a type of sarcoma, is a malignant neoplasm with uncertain origins that arise from both the soft tissues and the bone. The occurrence of MFH on the chest wall is extremely rare. We hereby report a case of a 72-year-old woman who was incidentally detected with MFH after a traffic accident. PMID:25024723

Hwang, Ki-Eun; Hwang, June-Seong; Kim, Kyung-Min; Jung, Jae-Wan; Oh, Su-Jin; Kim, Eun-Kyoung; Ryu, Dae-Woon; Choi, Keum-Ha; Jeong, Eun-Taik

2014-01-01

146

Epilepsy misdiagnosed as long QT syndrome: it can go both ways.  

PubMed

Cardiogenic seizures are common and could be the sentinel event heralding the presence of congenital long QT syndrome (LQTS). Distinguishing a cardiogenic seizure from a neurogenic one is of the utmost importance. Herein, we present the case of a 12-year-old boy with recurrent episodes of syncope and seizures. Despite absence of QT prolongation on electrocardiogram, absence of documented arrhythmias, a negative LQTS genetic test, and recurrent episodes while on nadolol beta-blocker therapy, he was diagnosed with LQTS and implanted with an implantable cardioverter defibrillator (ICD). When syncope and seizure occurred with normal sinus rhythm documented on the ICD, he was referred to neurology, and an electroencephalogram was positive for numerous bursts of bilaterally synchronous generalized discharges. He was started on antiepileptic treatment after which his seizures resolved. His LQTS diagnosis was removed, beta-blocker therapy discontinued, and his ICD was explanted. He has been seizure-free for over 2 years. PMID:23750755

Medford, Beth A; Bos, J Martijn; Ackerman, Michael J

2014-01-01

147

Diffuse colorectal angiodysplasia misdiagnosed preoperatively as ulcerative colitis in a child: report of a case.  

PubMed

Angiodysplasia is primarily a disease of the elderly, and it is rarely encountered in the pediatric population. We report a case of diffuse colorectal angiodysplasia, diagnosed postoperatively in a 13-year-old boy who underwent hand-assisted laparoscopic total proctocolectomy and ileal pouch anal anastomosis (IPAA) for assumed corticosteroid-resistant ulcerative colitis. The findings of preoperative repeated colonoscopies and biopsies had been consistent with active colitis. Distinguishing ulcerative colitis from angiodysplasia is not usually difficult in patients with rectal bleeding. To our knowledge, this is the fi rst case report of such a challenging diagnostic problem. PMID:18668317

Ozer, Ilter; Birol Bostanci, E; Ozogul, Yusuf B; Ulker, Aysel; Temucin, Tulay; Akoglu, Musa

2008-01-01

148

Wernicke's Encephalopathy After Laparoscopic Roux-en-Y Gastric Bypass: A Misdiagnosed Complication  

Microsoft Academic Search

Malabsorptive syndromes and micronutrient deficiencies represent well-known long-term complications of bariatric surgery.\\u000a Wernicke's encephalopathy (WE), a neurologic manifestation of thiamine deficiency, has been classically associated with alcoholism\\u000a or severe malnutrition, but rarely reported after bariatric surgery. Herein, we describe the case of a 27-year-old woman that\\u000a developed WE 10 months after laparoscopic Roux-en-Y gastric bypass for morbid obesity that was initially

Antonio Iannelli; Pietro Addeo; Sebastien Novellas; Jean Gugenheim

2010-01-01

149

Wernicke’s Encephalopathy After Laparoscopic Roux-en-Y Gastric Bypass: A Misdiagnosed Complication  

Microsoft Academic Search

elucidation. The proclamation that the half-life of thiamine is 10 to 20 days is inaccurate, and this should be corrected. Thiamine deficiency leads to brain lesions—usually constrained to selective, vulnerable regions, with high thiamine content and turnover—within 2– 3w eeks [2]. This timescale is related to the time necessary to deplete the body’s stores of thiamine which is only sufficient

Nishant Tageja

2010-01-01

150

Tibial torus and toddler's fractures misdiagnosed as transient synovitis: a case series  

PubMed Central

Introduction The high incidence of transient synovitis in early childhood makes it the first suspected pathology in a limping child. Trauma, which has long been regarded as a causative factor for transient synovitis, may be underestimated in a non-cooperative toddler. After excluding most serious conditions, such as septic arthritis, a speculative diagnosis of transient synovitis can be made, and this can easily mask a subtle musculoskeletal injury. Case presentations We report the cases of three Caucasian patients (two boys, aged 20-months- and three-years-old, and one girl, aged two-years-old), with tibial torus and toddler's fractures which were late-diagnosed due to an initial misdiagnosis of transient synovitis of the hip. Conclusion In a non-cooperative child musculoskeletal trauma can be mistaken as a simple causative factor for transient synovitis of the hip and this can easily prevent further investigation for a possible subtle musculoskeletal injury of the lower extremities. Our experience with the presented cases suggests the need to be more vigilant in the differential diagnosis of transient synovitis in young children. PMID:21752248

2011-01-01

151

Juvenile Kearns-Sayre syndrome initially misdiagnosed as a psychosomatic disorder  

Microsoft Academic Search

We have investigated a 15 year old girl with progressive external ophthalmoplegia, including bilateral ptosis and retinal rod and cone cell dysfunction with atypical retinal pigmentation, complicated by cerebellar ataxia, partial cardiac conduction block, and diabetes mellitus. In infancy she had a severe crisis of bone marrow depression, and as a child she suffered from hypersensitivity to light, increasing fatigue,

S Nørby; P Lestienne; I Nelson; I M Nielsen; H Schmalbruch; O Sjö; M Warburg

1994-01-01

152

3-Methyl glutaconic aciduria in Iraqi Jewish children may be misdiagnosed as cerebral palsy.  

PubMed

It is generally accepted that patients with cerebral palsy suffer from a static encephalopathy causing a non-progressive disorder of posture and/or movement. We describe 7 patients from 5 families who were initially diagnosed with cerebral palsy. Eventually, excessive excretion of urinary 3-methyl glutaconic acid (3-MGA) was found. The data of our 7 patients are quite similar to the clinical description of Costeff et al (1989): Jewish-Iraqi origin (7/7), consanguinity (2/7), involuntary movements (5/7), ataxia (6/7), pyramidal involvement (6/7) and optic atrophy (6/7). The cognitive functions were intact in 5/7 and 2/7 showed mild to moderate mental retardation. The mean delay in the definitive diagnosis was 9 years. Cerebral palsy-like symptoms accompanied by optic atrophy and extrapyramidal signs should call for extensive metabolic evaluation including the determination of urinary 3-MGA. PMID:9553953

Straussberg, R; Brand, N; Gadoth, N

1998-02-01

153

Q Fever with Unusual Exposure History: A Classic Presentation of a Commonly Misdiagnosed Disease  

PubMed Central

We describe the case of a man presumptively diagnosed and treated for Rocky Mountain spotted fever following exposure to multiple ticks while riding horses. The laboratory testing of acute and convalescent serum specimens led to laboratory confirmation of acute Q fever as the etiology. This case represents a potential tickborne transmission of Coxiella burnetii and highlights the importance of considering Q fever as a possible diagnosis following tick exposures. PMID:22848855

Nett, Randall J.; Book, Earl; Anderson, Alicia D.

2012-01-01

154

"Why do I always see double?" A misdiagnosed case of ocular myasthenia gravis for 10 years.  

PubMed

A 58-year-old man presented with diplopia and partial ptosis for 10 years. It was non-progressive in nature, despite inadequate medical attention the patient received from non-specialists/general practitioners. He did not have fatigability or diurnal variation in weakness and was clinically stable without exacerbations of disease for a decade. He did not have features of Graves's disease, oculopharyngeal dystrophy, cranial nerve paralysis, polymyositis and stroke. The possibility of an atypical presentation of myasthenia gravis (MG) was considered and the patient was evaluated. Ice pack test was negative, Cogan's lid twitch (CLT) test was positive and high titres of acetylcholine receptor antibodies (AChR Ab) suggestive of MG were found. He was treated accordingly with a very good response. PMID:24792021

Yousuf, Uduman Ali Mohamed; Yashodhara, B M; Thanigasalam, Thevi; Ting, Heng Siang

2014-01-01

155

Child abuse and osteogenesis imperfecta: how can they be still misdiagnosed? A case report  

PubMed Central

Summary Osteogenesis imperfecta (OI) is a rare hereditary disease caused by mutations in genes coding for type I collagen, resulting in bone fragility. In literature are described forms lethal in perinatal period, forms which are moderate and slight forms where the only sign of disease is osteopenia. Child abuse is an important social and medical problem. Fractures are the second most common presentation after skin lesions and may present specific patterns. The differential diagnosis between slight-moderate forms of OI and child abuse could be very challenging especially when other signs typical of abuse are absent, since both could present with multiple fractures without reasonable explanations. We report a 20 months-old female with a history of 4 fractures occurred between the age of three and eighteen months, brought to authorities’ attention as a suspected child abuse. However when she came to our department physical examination, biochemical tests, total body X-ray and a molecular analysis of DNA led the diagnosis of OI. Thus, a treatment with bisphosphonate and a physical rehabilitation process, according to Vojta method, were started with improvement in bony mineralization, gross motor skills and absence of new fracture. In conclusion our case demonstrates how in any child presenting fractures efforts should be made to consider, besides child abuse, all the other hypothesis even the rarest as OI. PMID:23289038

D'Eufemia, Patrizia; Palombaro, Marta; Lodato, Valentina; Zambrano, Anna; Celli, Mauro; Persiani, Pietro; De Bari, Maria Pia; Sangiorgi, Luca

2012-01-01

156

Acute intermittent porphyria caused by novel mutation in HMBS gene, misdiagnosed as cholecystitis  

PubMed Central

Background Acute intermittent porphyria (AIP) is an autosomal dominant neurovisceral inherited disorder due to a defect in the heme biosynthesis pathway. Misdiagnosis of the porphyrias is not uncommon. Case report We present a case of a 26-year-old female with suspected acute cholecystitis, mental status changes, and seizures. Biochemical and molecular investigations confirmed the diagnosis of AIP by findings of elevated urinary porphobilinogen, 5-aminolevulinic acid, and total porphyrins. DNA molecular testing showed a novel heterozygous mutation (c. 760delC p.L254X) in the exon11 of the HMBS gene. To the best of our knowledge, this is the first report of a misdiagnosis of AIP presenting with acute cholecystitis. Conclusion Clinicians are alerted to consider the possibility of AIP in an adult presenting with an acute abdomen, features of cholecystitis, and neuropsychiatric manifestations.

Alfadhel, Majid; Saleh, Neam; Alenazi, Helal; Baffoe-Bonnie, Henry

2014-01-01

157

Imiquimod therapy for extramammary Paget's disease of the vulva: a viable non-surgical alternative.  

PubMed

Extramammary Paget's disease (EMPD) is a rare intraepidermal adenocarcinoma that can affect the vulval skin. Surgical excision is the gold-standard treatment, however, recurrence rates are high and extensive excisions can produce long-lasting cosmetic and functional defects. We describe one of the largest case series to-date (n = 6) on the use of topical 5% imiquimod cream as a novel treatment option and discuss our experiences. With the addition of our six cases to the literature, there are now 29 documented cases of vulval EMPD treated with 5% imiquimod cream. Of these, 50% of primary disease cases and 73% of recurrent primary disease cases have achieved clinical resolution with 5% imiquimod therapy alone. These findings suggest that imiquimod provides a viable alternative to surgical excision for vulval EMPD. However, we acknowledge that this is a simple retrospective analysis and that treatment scheduling and follow-up needs investigation in a trial setting. PMID:23815201

Sanderson, P; Innamaa, A; Palmer, J; Tidy, J

2013-07-01

158

Co-existence of extramammary Paget's disease and Bowen's disease of vulva.  

PubMed

Extramammary Paget's disease and Bowen's disease are histologically similar and immunohistochemistry is often required to make the diagnosis. We present a case of vulval Paget's disease with Bowen's disease in an elderly female. Strong positivity for cytokeratin 7, anti CAM 5.2, carcinoembryonic antigen (CEA) and periodic acid-Schiff (PAS) stain in clitoral, left labial and interface regions of the vulvectomy specimen confirmed the diagnosis of Paget's disease (PD) while positive staining for p63 in the right labial and interface regions helped in establishing the diagnosis of concurrent Bowen's disease (BD). PMID:25382511

Goyal, Tarang; Varshney, Anupam; Solanki, Ranjan

2014-01-01

159

Velvet Vulvas at School: The Catalyzing Power of the Arts in Education  

ERIC Educational Resources Information Center

As a teacher of art teachers, this author values and promotes an education through the arts that loves freedom, an education through art connected to powerful social ideas and movements, connected to social justice. This is not a kind of education common today in public schools, but it has a rich lineage. Drawing inspiration from Maxine Greene,…

Quinn, Therese

2008-01-01

160

Vulvar dermatoses--irritant and allergic contact dermatitis of the vulva.  

PubMed

Irritant and allergic contact dermatitis are commonly seen in patients complaining about itching, burning and irritation in the vulvar area. Irritation often precedes allergic sensitization. Clinically, irritant and allergic contact dermatitis can be difficult to distinguish. Diagnosis is made by history, clinical investigation and patch testing. Recommended patch test series are the standard series, a medicament series, the patient's own topical medicaments, popular remedies and other suspected products. A skin biopsy may be useful to establish the diagnosis of contact dermatitis, but it is usually not helpful for the differential diagnosis between irritant and allergic dermatitis. PMID:15724097

Bauer, A; Rodiger, C; Greif, C; Kaatz, M; Elsner, P

2005-01-01

161

Searching: the lived experience of women with cancer of the vulva.  

PubMed

Although the physical adverse effects following surgery for vulval cancer may readily be described, little is known about the psychological, emotional, and social impact. A review of the literature revealed a paucity of studies, as this condition is rare. To explore the lived experiences of women in the United Kingdom with vulval cancer, a qualitative research study was undertaken using the research methodology of interpretive phenomenology, based on the work of Heidegger (The Essence of Human Freedom. London: Continuum; 2005) and van Manen (Researching Lived Experience. Human Science for an Action Sensitive Pedagogy. New York: State University of New York Press; 1990). Thirteen women younger than 50 years were interviewed between 6 months and 5 years after their surgery, and the data were analyzed using framework analysis (Qualitative data analysis for applied policy research. In: Analysing Qualitative Data. London: Routledge; 1994:173-194). This article describes how the concept of searching emerged from the data. It also describes the manner in which the women searched to control their symptoms by their own efforts and by undergoing surgery. The search to understand the truth about their condition and their access to information in the search for meaning and the time element in which this was undertaken was also raised. An underlying consideration is the need for health professionals to help provide the information and support needed to manage this condition. PMID:19816158

Jefferies, Hilary; Clifford, Collette

2009-01-01

162

Solitary fibrous tumor arising slowly in the vulva over 10 years: case report and review.  

PubMed

Solitary fibrous tumor (SFT), which was first described as a pleural lesion by Klemperer and Rabin in 1931, is a rare, slow-growing neoplasm characterized by the proliferation of fibroblast-like spindle cells arranged in a patternless manner with few nuclear atypia. Extrathoracic SFT have increasingly been recognized, but those in the genital tract are extremely rare. Gynecological SFT behave as tumors with low malignant potential to recur, metastasize, or affect nearby organs resulting in infertility. We report a case of vulvar SFT slowly growing for 10 years, and propose a strategy for the diagnosis and treatment of gynecological SFT. PMID:22449361

Taki, Mana; Baba, Tsukasa; Mandai, Masaki; Suzuki, Ayako; Mikami, Yoshiki; Matsumura, Noriomi; Konishi, Ikuo

2012-05-01

163

Vulvitis granulomatosa and unilateral hypertrophy of the vulva related to Crohn's disease: a case report.  

PubMed

We report the case of a patient with voluminous unilateral hypertrophy of vulvar labia and pseudocondylomata in the fossa navicularis associated with intestinal Crohn's disease. No fistulas were observed. The patient has had Crohn's disease for 8 years. Interrelationship of genital alterations and Crohn's disease are discussed. PMID:15547549

Günthert, Andreas R; Hinney, Bernd; Nesselhut, Kirsten; Hanf, Volker; Emons, Günter

2004-11-01

164

Refractory Crohn's disease of the vulva treated with infliximab: A case report  

PubMed Central

Crohn’s disease (CD) is a chronic relapsing and remitting inflammatory disorder of the gastrointestinal tract. The common presentation includes abdominal pain, abdominal cramping and diarrhea. Many patients may exhibit systemic symptoms of fever and weight loss. Approximately 20% to 40% of patients will experience extraintestinal manifestations that involve the eyes, skin and joints. Women may experience a variety of gynecological manifestations, including vulvovaginal involvement, which is often not recognized and also difficult to treat. A case of refractory vulvovaginal CD is presented and the literature of gynecological manifestations of CD and its treatment are reviewed. PMID:18080056

Makhija, Sapna; Trotter, Martin; Wagner, Elizabeth; Coderre, Sylvain; Panaccione, Remo

2007-01-01

165

Pseudobowenoid change of the vulva: a histologic variant of untreated condylata acuminatum.  

PubMed

Vulvar condylomata are distinguished from vulvar intraepithelial neoplasia by orderly maturation, a low mitotic index, and the absence of nuclear atypia in the lower epithelial layers. Podophyllin therapy might produce changes in condylomata mimicking vulvar intraepithelial neoplasia but can be distinguished, particularly with a recent history of podophyllin use. This report describes five patients with vulvar condylomata that morphologically resemble both podophyllin effect and vulvar intraepithelial neoplasia. The mean age was 30.5 years. All lesions exhibited superficial keratinocytes in various stages of apoptosis, with a spectrum of nuclear degenerative changes characterized by absence of the nuclear membrane and dispersed nuclear chromatin. The characteristic finding was a perichromatin halo delineated by a rim of dense cytoplasm, beyond which a second zone of uniform clearing was observed, similar to changes noted in vulvar intraepithelial neoplasia. There was an absence, however, of either nuclear atypia in the lower cell layers or apoptosis and mitotic arrest observed in vulvar intraepithelial neoplasia and podophyllin therapy. Two (50%) of four lesions tested positive for human papillomavirus nuclei acids, one by polymerase chain reaction and the other by DNA-DNA in situ hybridization. No common human papillomavirus types were found. Pseudobowenoid change might represents a distinct type of vulvar condyloma, perhaps related to an unusual human papillomavirus. PMID:8729975

Nucci, M R; Genest, D R; Tate, J E; Sparks, C K; Crum, C P

1996-04-01

166

Primary pleural squamous cell carcinoma misdiagnosed as localized mesothelioma: a case report and review of the literature  

PubMed Central

Primary pleural squamous cell carcinoma is very rare, and there is a lack of experience in the diagnosis and treatment of this condition. An asymptomatic 75-year-old man was referred to us after a right pleural nodule was found on computed tomography during a routine health examination. He underwent surgery for his pleural tumor twice over the following 2 years. Histopathological examination eventually led to a diagnosis of primary pleural squamous cell carcinoma. PMID:23497477

2013-01-01

167

CT Diagnosis of a Thoracic Aort Aneurysm with Type B Aortic Dissection Clinically Misdiagnosed as Acute Pulmonary Embolism.  

PubMed

A 54-year-old man was admitted to the emergency department, presenting with an acute onset of chest pain and severe respiratory distress symptoms. He was medicated with intravenous analgesia and antihypertensive drugs. The patient was subjected to a chest X-ray which revealed a prominent widening of the mediastinum and pleural effusion on the left side. In laboratory tests-d-dimer level was highly elevated. The patient was clinically interpreted as having an acute pulmonary embolism and referred to the radiology clinic to perform a computed tomography (CT) examination. Contrast-enhanced CT demonstrated that there was no abnormality related to the pulmonary vasculature, but a huge thoracic aorta aneurysm measuring 11 × 8.1 × 7.7?cm in diameter was detected. Accompanying the aneurysm, an intimal flap was also present in the proximal descending thoracic aorta, distal to the origin of the left subclavian artery and extending into the bifurcation level. The patient was therefore diagnosed as having a type B aortic dissection as well. Once these serious conditions were detected, he was immediately transferred to a cardiovascular thoracic surgery hospital for endovascular repairment operation. PMID:22991520

Halefoglu, Ahmet Mesrur

2012-01-01

168

Should Steroid Therapy Be Necessarily Needed for Autoimmune Pancreatitis Patients with Lesion Resected due to Misdiagnosed or Suspected Malignancy?  

PubMed Central

To explore whether steroid therapy should be needed for autoimmune pancreatitis patients after operation, eight AIP patients receiving operation were enrolled in this study from January 2007 to July 2013. All patients underwent liver function, CA19-9, and contrast-enhanced CT and/or MRI. Tests of IgG and IgG4 were performed in some patients. Tests of serum TB/DB, ?-GT, and ?-globulin were undergone during the perioperative period. Six cases receiving resection were pathologically confirmed as AIP patients and two were confirmed by intraoperative biopsy. For seven patients, TB/DB level was transiently elevated 1 day or 4 days after operation but dropped below preoperative levels or to normal levels 7 days after operation, and serum ?-GT level presented a downward trend. Serum ?-globulin level exhibited a downward trend among six AIP patients after resection, while an upward trend was found in another two AIP patients receiving internal drainage. Steroid therapy was not given to all six AIP patients until two of them showed new lines of evidence of residual or extrapancreatic AIP lesion after operation, while another two cases without resection received steroid medication. Steroid therapy might not be recommended unless there are new lines of evidence of residual extrapancreatic AIP lesions after resection. PMID:24578705

Wu, Wenchuan; Yao, Xiuzhong; Lin, Chao; Jin, Dayong; Wang, Dansong; Lou, Wenhui; Qin, Xinyu

2014-01-01

169

Hepatoerythropoietic Porphyria Misdiagnosed as Child Abuse: Cutaneous, Arthritic, and Hematologic Manifestations in Siblings with a Novel UROD Mutation  

PubMed Central

Background Hepatoerythropoietic porphyria (HEP) is a rare autosomal recessive disorder resulting from the markedly deficient, but not absent, activity of the heme biosynthetic enzyme, uroporphyrinogen decarboxylase (UROD). HEP typically manifests during infancy or early childhood with extreme photosensitivity, skin fragility in sun-exposed areas, hypertrichosis, erythrodontia, and pink urine. Observations We describe three siblings, offspring of parents of Puerto Rican and Dominican descent, who presented with excessive scarring on the face and dorsal aspect of the forearms, which initially led to the erroneous suspicion of child abuse. Although these lesions were photodistributed, overt photosensitivity had not been observed, with the exception of a single episode of blistering and onycholysis following intense sun exposure in one affected child. Mild facial hypertrichosis, chronic anemia, polyarticular arthritis, and developmental delay represented additional findings. Biochemical studies of urine, plasma, and erythrocyte porphyrins from the affected siblings established the diagnosis of HEP. Sequencing of the UROD gene revealed compound heterozygosity for a novel missense mutation, V166A, and a complex deletion/insertion, 645del1053ins10. Conclusions Our report expands the phenotypic and genotypic spectrum of HEP, highlighting mild cutaneous presentations that can occur without obvious photosensitivity and potentially masquerade as child abuse. PMID:20479301

Cantatore-Francis, Julie L.; Cohen, Jessica; Balwani, Manisha; Kahn, Philip; Lazarus, Herbert M.; Desnick, Robert J.; Schaffer, Julie V.

2011-01-01

170

Sodium Tetradecyl Sulphate Direct Intralesional Sclerotherapy of Venous Malformations of the Vulva and Vagina: Report of Five Cases  

SciTech Connect

We report five cases of female patients affected by symptomatic focal external genital venous malformations treated with percutaneous direct intralesional injection of sodium tetradecyl sulphate (STS). All patients were referred because of discomfort and pain when sexual intercourse was attempted. Direct sclerotherapy with 3% STS was performed on a day-hospital basis with the patient under local anesthesia. Complete resolution of the symptoms was achieved in all cases. No major adverse effects were reported. Direct intralesional sclerotherapy with STS may be considered a safe and effective method for the treatment of female external genital malformation without the necessity of general anesthesia for pain control.

Krokidis, Miltiadis, E-mail: mkrokidis@hotmail.com [Guy's and St. Thomas' NHS Trust, Department of Radiology (United Kingdom); Venetucci, Pietro [University Hospital 'Federico II', Department of Cardiovascular and Interventional Radiology (Italy); Hatzidakis, Adam [Medical School of Crete (Greece); Iaccarino, Vittorio [University Hospital 'Federico II', Department of Cardiovascular and Interventional Radiology (Italy)

2011-02-15

171

Melanoma of the vulva: a pigmented lesion is also significant in a non-sun-exposed area  

Microsoft Academic Search

Purpose  The foremost important aetiological factor for malignant melanoma is considered to be sunlight exposure. However, primary\\u000a lesions are also seen in non-sun-exposed areas. Vulvar melanoma is rare and associated with impaired outcome. Herein, we attempt\\u000a to increase physicians’ awareness for early diagnosis in order to improve prognosis.\\u000a \\u000a \\u000a \\u000a Case report   A 64-year-old female presented with pruritus and irritation at her external

Sophia Parara; Eelco de Bree; Dimitris Takos; Elpida Giannikaki; John Melissas; Dimitris D. Tsiftsis

2009-01-01

172

Sodium tetradecyl sulphate direct intralesional sclerotherapy of venous malformations of the vulva and vagina: report of five cases.  

PubMed

We report five cases of female patients affected by symptomatic focal external genital venous malformations treated with percutaneous direct intralesional injection of sodium tetradecyl sulphate (STS). All patients were referred because of discomfort and pain when sexual intercourse was attempted. Direct sclerotherapy with 3% STS was performed on a day-hospital basis with the patient under local anesthesia. Complete resolution of the symptoms was achieved in all cases. No major adverse effects were reported. Direct intralesional sclerotherapy with STS may be considered a safe and effective method for the treatment of female external genital malformation without the necessity of general anesthesia for pain control. PMID:20559638

Krokidis, Miltiadis; Venetucci, Pietro; Hatzidakis, Adam; Iaccarino, Vittorio

2011-02-01

173

The Caenorhabditis elegans CDT-2 ubiquitin ligase is required for attenuation of EGFR signalling in vulva precursor cells  

E-print Network

Abstract Background Attenuation of the EGFR (Epidermal Growth Factor Receptor) signalling cascade is crucial to control cell fate during development. A candidate-based RNAi approach in C. elegans identified CDT-2 as an attenuator of LET-23 (EGFR...

Poulin, Gino B; Ahringer, Julie

2010-10-26

174

Sodium Tetradecyl Sulphate Direct Intralesional Sclerotherapy of Venous Malformations of the Vulva and Vagina: Report of Five Cases  

Microsoft Academic Search

We report five cases of female patients affected by symptomatic focal external genital venous malformations treated with percutaneous\\u000a direct intralesional injection of sodium tetradecyl sulphate (STS). All patients were referred because of discomfort and pain\\u000a when sexual intercourse was attempted. Direct sclerotherapy with 3% STS was performed on a day-hospital basis with the patient\\u000a under local anesthesia. Complete resolution of

Miltiadis Krokidis; Pietro Venetucci; Adam Hatzidakis; Vittorio Iaccarino

2011-01-01

175

Why are recurrent cervical cancers of the pelvic stump misdiagnosed as interstitial cystitis?: The urologist's point of view based on a case report  

PubMed Central

A 50-year-old female who had undergone laparoscopic total hysterectomy at a local clinic owing to leiomyoma of the uterus was referred to our hospital after having dysuria, urgency, frequency, lower abdominal pain and right flank pain over several months. After routine examinations, cystoscopy, computed tomography and magnetic resonance imaging were performed, and non-ulcerative interstitial cystitis accompanied by postoperative fibrosis secondary to a previous surgery was suggested. Pentosan sulfuric polyester (Elmiron, Alza Pharmaceuticals, Mountain View, CA) reduced her severely debilitating symptoms and improved her quality of life. Both the hydronephrosis and the symptoms were relieved by ureteral stent insertion and percutaneous nephrostomy. However, a few days later, she presented with vaginal bleeding along with her previous symptoms, and punch biopsy of the vaginal stump resulted in a diagnosis of adenocarcinoma. Both ureterocutaneostomy with radical cystectomy and lower anterior resection for rectum invasion were conducted. After the slide review of the original specimen from the local clinic, she was diagnosed with recurrent cervical cancer of the vaginal stump. PMID:23766840

Oh, Jin Kyu; Kim, Khae-Hawn

2013-01-01

176

Identification of three novel OA1 gene mutations identified in three families misdiagnosed with congenital nystagmus and carrier status determination by real-time quantitative PCR assay  

PubMed Central

Background X-linked ocular albinism type 1 (OA1) is caused by mutations in OA1 gene, which encodes a membrane glycoprotein localised to melanosomes. OA1 mainly affects pigment production in the eye, resulting in optic changes associated with albinism including hypopigmentation of the retina, nystagmus, strabismus, foveal hypoplasia, abnormal crossing of the optic fibers and reduced visual acuity. Affected Caucasian males usually appear to have normal skin and hair pigment. Results We identified three previously undescribed mutations consisting of two intragenic deletions (one encompassing exon 6, the other encompassing exons 7–8), and a point mutation (310delG) in exon 2. We report the development of a new method for diagnosis of heterozygous deletions in OA1 gene based on measurement of gene copy number using real-time quantitative PCR from genomic DNA. Conclusion The identification of OA1 mutations in families earlier reported as families with hereditary nystagmus indicate that ocular albinism type 1 is probably underdiagnosed. Our method of real-time quantitative PCR of OA1 exons with DMD exon as external standard performed on the LightCycler™ allows quick and accurate carrier-status assessment for at-risk females. PMID:12515581

Faugere, Valerie; Tuffery-Giraud, Sylvie; Hamel, Christian; Claustres, Mireille

2003-01-01

177

F-18 FDG hypermetabolism in mass-forming focal pancreatitis and old hepatic schistosomiasis with granulomatous inflammation misdiagnosed by PET/CT imaging  

PubMed Central

Purpose: We report the case of a 59-year-old male patient who presented with space-occupying lesions in the pancreas and liver suggestive of metastatic pancreatic cancer. Materials and methods: Whole-body F-18 fluorodeoxyglucose (FDG) PET/CT imaging and enhanced CT imaging of the lesions were performed in addition to abdominal ultrasound, ERCP, and MRCP. Tumor markers, including CA199 and AFP, were also evaluated. Results: PET/CT imaging showed a soft tissue mass with indistinct boundaries in the head of the pancreas with a maximum SUV of 4.39. A less dense shadow was also found in the left lobe of the liver with an indistinct boundary and a maximum SUV of 4.13. Enhanced CT revealed an enhancing mass in the head of the pancreas on arterial phase imaging as well as a mildly enhancing focus in the left lobe of the liver. The patient was diagnosed with a space-occupying lesion of the uncinate process of the pancreas suggestive of pancreatic cancer with metastasis to the liver. However, serum tumor markers were normal. Postoperative pathology was consistent with chronic pancreatitis and old hepatic schistosomiasis associated with granulomatous inflammation of the liver. Conclusion: This case of mass-forming pancreatitis and granulomatous inflammation in old hepatic schistosomiasis mimicked metastatic pancreatic cancer on PET/CT. Such false positive lesions have not been reported before, and further exploration and investigation are needed. PMID:25337288

Ye, Song; Wang, Wei-Lin; Zhao, Kui

2014-01-01

178

An exploration of the psychosocial effects that school-age children with Child Absence Epilepsy (CAE) experience their condition is misdiagnosed as Atention-Deficit/Hyperactivity Disorder (ADHD).  

E-print Network

??Masters of Philosophy%%%In today's society, the misdiagnosis of school-age children with the neurological condition Child Absence Epilepsy (CAE) as having Attention-Deficit/Hyperactivity Disorder (ADHD) has a… (more)

Raffaele, Martin

2009-01-01

179

C. elegans as a model organism for in vivo screening in cancer: effects of human c-Met in lung cancer affect C. elegans vulva phenotypes  

PubMed Central

Cancers typically harbour several mutant forms of key cellular genes that contribute to its complex phenotype. Our lab has previously identified gain-of-function mutations in some of the receptor tyrosine kinases such as c-Met in lung cancer. In order to investigate the mutant gene in the context of a whole organism, the current choice of in vivo model is limited to the mouse. To rapidly screen the functional aspects of mutant forms of c-Met detected in lung cancer, we used the nematode C. elegans as the model organism. Transgenic worms were generated that harbour wild type or the frequently seen mutant forms of c-Met in lung cancer (c-MetR988C and c-MetT1010I). Expression of the mutant human c-Met forms in C. elegans consistently resulted in significantly low fecundity and abnormal vulval development characterized by hyperplasia. Interestingly, exposure of c-Met mutant transgenic worms to nicotine resulted in enhanced abnormal vulval development, fecundity, and locomotion. Our studies provide first evidence that human c-Met mutations can be studied in C. elegans, and that carcinogens can enhance mutant c-Met function expressed in C. elegans transgenic animals. We therefore propose the use of C. elegans as a model to rapidly assess the role of cancer specific gene mutations in the context of a whole organism. PMID:18340114

Siddiqui, Shahid S.; Loganathan, Sivakumar; Krishnaswamy, Soundararajan; Faoro, Leonardo; Jagadeeswaran, Ramasamy; Salgia, Ravi

2008-01-01

180

Blood supply and innervation of the supermedial thigh flap employed in one-stage reconstruction of the scrotum and vulva--an anatomical study.  

PubMed

The supermedial thigh flap is an arterial and sensate flap. Anatomical studies reveal both large and small nutrient arteries. Its largest and most consistent artery is the superficial branch of the deep external pudendal artery, which constitutes the main circulation. The secondary blood supply to the base of the flaps is contributed by musculocutaneous perforators of the medial circumflex femoral artery. Subcutaneous branches of the superficial femoral artery, when present, are an additional source of arterial supply. Branches of the ilioinguinal nerve provide sensory innervation to the flaps. PMID:6524843

Har-Shai, Y; Hirshowitz, B; Marcovich, A; Eliachar, I; Peretz, B A

1984-12-01

181

“Proximal-type” epithelioid sarcoma vs. malignant rhabdoid tumor of the vulva: A case report, review of the literature, and an argument for consolidation  

Microsoft Academic Search

Background.Vulvar sarcomas, which comprise less than 2% of vulvar malignancies, are a heterogeneous group of tumors. Sub-categorization of these tumors makes treatment strategies difficult to evaluate. “Proximal” type epithelioid sarcoma (PES) and malignant rhabdoid tumor (MRT) describe a rare subset of vulvar malignancies which share histologic features and an aggressive clinical course.

Peter A. Argenta; Sajeena Thomas; Justin C. Chura

2007-01-01

182

A composite neoplastic lesion of the vulva with mixed features of fibroadenoma and hidradenoma papilliferum combined with pseudoangiomatous stromal hyperplasia containing multinucleated giant cells.  

PubMed

Anogenital mammary-like glands (AGMLG) are nowadays considered a normal component of the anogenital area. Lesions affecting AGMLG are similar to those seen in breast. We present a case of a complex neoplastic lesion of the AGMLG with mixed features of fibroadenoma and hidradenoma papilliferum combined with pseudoangiomatous stromal hyperplasia. Multinucleated cells were detected in the pseudoangiomatous stromal hyperplasia areas as seen in some patients with neurofibromatosis type 1. The neoplasm is similar to rare mammary composite neoplasms that feature simultaneously patterns of a fibroepithelial neoplasms and intraductal papilloma. PMID:23503319

Konstantinova, Anastasia M; Kacerovska, Denisa; Michal, Michal; Kazakov, Dmitry V

2014-10-01

183

Circuits attenuating seizures under well-fed and food-deprived conditions in C. elegans male sex muscles  

E-print Network

. Specifically, I focused on the step wherein the male inserts his copulatory spicules into the hermaphrodite vulva, as vulva penetration is required for successful sperm transfer. This step must be tightly regulated; if the spicules protract too soon...

Leboeuf, Brigitte L.

2010-07-14

184

Revision and Phylogenetic Analysis of the North American Antlion Genus Paranthaclisis Banks (Neuroptera: Myrmeleontidae)  

E-print Network

/3 posterior gonapophysis length; gonapophyseal plate: glabrous, running transversely from posterior gonapophyses to base of vulva; lateral gonapophyses: produced parasagittally posterior to vulva, thumb-like, shorter than posterior gonapophyses, length 1 1...

Diehl, Benjamin

2012-10-19

185

Trichomoniasis  

MedlinePLUS

... partner. This include penis-to-vagina intercourse or vulva-to-vulva contact. The parasite cannot survive in the mouth ... care provider if any unusual vaginal discharge or irritation is noted. Also call for an appointment if ...

186

Functional Dissection of the Sensory Rays in Caenorhabditis elegans Male Mating Behavior  

E-print Network

tail ventrally along the hermaphrodite cuticle. B. Scanning. The male proceeds to back along the hermaphrodite cuticle in search of the vulva. C. Turning. If he reaches the head or tail end of his mate, the male performs a sharp ventral turn... to reach the opposite side of the hermaphrodite, then resumes scanning. D. Prodding and insertion. When the male locates the vulva (dashed white line), he ceases backwards locomotion and prods rapidly against the vulva opening to part the vulva walls...

Koo, Pamela Kristine

2012-02-14

187

An exploration of the psychosocial effects that school-age children with Child Absence Epilepsy (CAE) experience when their condition is misdiagnosed as Attention Deficit-Hyperactivity Disorder (ADHD)  

Microsoft Academic Search

The purpose of this study is to provide an understanding of the psychosocial effects of the misdiagnosis on these children. To also publish data that is not available at this time, and offer findings that will create a foundation for further research. This study is to be conducted by a researcher who has experience working with adolescents and young adults

Martin Raffaele

188

Parasites associated with exotic food  

Microsoft Academic Search

The short description of parasites associated with “exotic food” is by no means inclusive. Many others, such as Toxoplasma gondii, Spirometa spp. (sparganosis), Taenia saginata (cysticercosis), and Echinostoma malayanum, are transmitted via food. Raw sheep liver “sowda” is commonly consumed in Lebanon. Many people developed human toxocariasis after eating this dish (19). The economic loss associated with food-borne parasitic zoonoses

Susan M. Novak

1996-01-01

189

Double Muscling in Cattle.  

E-print Network

A1.4838 291.983 Figure 12. Diagrammatic representation of the external genitalia of a double-muscled heifer. Due largely to the bulging shape of the rear quarters, the vulva tends to be placed away from the vertical position and more towards... the horizontal (A). Because of abnormal position of ?the vulva, natural breeding may be difficult. The vulva is juvenile in development at all ages (B). 20 (Blank Page In Original BuUetinl 1 :: " , , . ?" I ? ~l. \\ ,3...

Kieffer, Nat M.; Cartwright, T.C.

1980-01-01

190

The neuromolecular mechanisms that coordinate food availability with C. elegans male sexual behavior  

E-print Network

for her vulva. If the male reaches the end of the hermaphrodite without sensing the vulva, he performs a ventral turn and scans the other side. Once he locates the vulva, he stops and attempts to insert his copulatory spicules into his mate. Spicule... insertion is achieved by rapid contraction of his sex muscles, which consist of two retractor muscles and two protractor muscles attached to each of his two spicules. Once he has breached the vulva, he maintains a tonic contraction of his sex muscles...

Gruninger, Todd Ryan

2009-05-15

191

Intrauterine temperatures of mares under different management conditions  

E-print Network

, with the suture hanging out of the vulva. Prior to this, the mare?s vulva and perineal area had been washed with a diluted Betadine scrub (Purdue Pharma, L.P., Stamford, Connecticut, 06901). Temperatures were recorded by the uterine device for 5 d; if at any..., with the suture hanging out of the vulva. Prior to this, the mare?s vulva and perineal area had been washed with a diluted Betadine scrub (Purdue Pharma, L.P., Stamford, Connecticut, 06901). Temperatures were recorded by the uterine device for 5 d; if at any...

Commaille, Lynn Frances

2009-05-15

192

Infectious Anaemia of the Horse: A Preliminary Report.  

E-print Network

-coated bowel discharges from the anus, (3) coffee-colored urine dribbling from the vulva. The mucous membranes of the mouth, anus and vulva are very pale or yellowish. Those of the eye and nose show petechiae. The pleurae, peritoneum and pericardium show...-coated bowel discharges from the anus, (3) coffee-colored urine dribbling from the vulva. The mucous membranes of the mouth, anus and vulva are very pale or yellowish. Those of the eye and nose show petechiae. The pleurae, peritoneum and pericardium show...

Francis, M. (Mark); Marsteller, R. P. (Ross Perry)

1908-01-01

193

Computerized dairy records management systems  

E-print Network

; e) presence of a moisten and swollen vulva; f) discharge of clear mucus from the vulva; and g) a small decrease in milk production (7, 9). It is the manager's responsibility to design the most effective method of observing and recognizing oestrus...; e) presence of a moisten and swollen vulva; f) discharge of clear mucus from the vulva; and g) a small decrease in milk production (7, 9). It is the manager's responsibility to design the most effective method of observing and recognizing oestrus...

Acosta, Alejandro E. Gonzalez

2012-06-07

194

Purdue extensionPurdue extension AS-561-WAS-561-W  

E-print Network

part, is the vulva. The vulva consists of a thick fold of skin that covers and protects the opening. The ovaries serve as the production site for ova, or eggs; the oviducts are the egg's path between the ovaries the reproductive tract until reaching the oviduct. When an egg is released from the ovary, it travels

195

Caenorhabditis elegans UNC-103 ERG-Like Potassium Channel Regulates Contractile Behaviors of Sex Muscles in Males before and during Mating  

Microsoft Academic Search

During mating behavior the Caenorhabditis elegans male must regulate periodic and prolonged protractor muscle contractions to insert his copulatory spicules into his mate. The protractors undergo periodic contractions to allow the spicules to reattempt insertion if a previous thrust failed to breach the vulva. When the spicule tips penetrate the vulva, the protractors undergo prolonged contraction to keep the spicules

L. Rene Garcia; Paul W. Sternberg

2003-01-01

196

HUMAN GENE THERAPY 17:147157 (February 2006) Mary Ann Liebert, Inc.  

E-print Network

of malignant disease including cancer of the vulva, oral cancer, and skin cancer. In HPV-transformed cells including cancer of the vulva (Basta et al., 1999) and oral cancer (Miller and Johnstone, 2001). Novel Kills Bystander Cells and Offers a Route for Cervical Cancer Gene Therapy KATIE L. GREEN,1 TOM D

Gaston, Kevin

197

Mycotoxins in Feed and Food Crops.  

E-print Network

are vulvovaginitis and aflatoxicosis. Vulvovaginitis is caused by a to~in produced by Fusarium graminearum. The first change noted in pigs consum ing this toxin is a gradual enlargement or swelling of the vulva. It seemingly differs in no way from enlargement... of the vulva due to the heat period, but the swelling continues until the vulva is smooth, very firm, tense and elevated or swollen out of the body. In some instances, there is vaginal prolapse. Gilts from 6 weeks old up to 100 to 150 pounds in weight...

Armstrong, James M.; Herb, Dennis B.; Bremer, John E.; Horne, C. Wendell; Thomas, William B.; Thornberry, Fred D.; Tripp, Leland D.; White, Thomas H.; Withers, Richard E.

1981-01-01

198

Artificial Insemination in Swine  

E-print Network

vulva, mucus from the vulva, ?popping? of the ears, and increased vocalization and activity. In gilts, estrus may only last a day or two, while a sow may be in estrus for 3 days. Ovulation (release of the egg from the follicle on the ovary) usually..., it is important to use the proper tech- nique and have an understanding of the reproductive system. Figure 1 shows the reproductive organs of the female swine. The vulva is the visible portion of the female reproductive tract and may be red and swollen before...

Sterle, Jodi

1999-09-03

199

An Unusual Gross Appearance of Vulval Tuberculosis Masquerading as Tumor  

PubMed Central

Tuberculosis of the vulva is very rare. It is found in about 0.2% of the cases of genital tract tuberculosis. It usually presents as small shallow ulcers and multiple sinus tracts or rarely as elephantiasis of vulva. Except for very rare cases of primary tuberculosis in the vulva, it is usually associated with tuberculosis elsewhere in the body leading to secondary tuberculosis. Here, we report a case of secondary vulval tuberculosis which presented as a vulval mass in a 40-year-old female patient. The rarity of this presentation in the female genital tract is emphasized. PMID:25298898

Arakeri, Surekha U.

2014-01-01

200

Copyright 2006 by the Genetics Society of America DOI: 10.1534/genetics.104.035550  

E-print Network

, migration, and differentiation, and the ras gene is frequently mutated in human tumors (Barbacid 1987 Caenorhabditis elegans, and its role in the development of the hermaphrodite vulva has been characterized

Kornfeld, S. Kerry

201

Copyright 2005 by the Genetics Society of America DOI: 10.1534/genetics.104.034173  

E-print Network

to be a frequent target of inactivation in many human cancers (Nevins 2001). The nematode Caenorhabditis elegans. The vulva of the C. elegans hermaphrodite is the con- duit through which embryos are expelled and is also

202

Psoriasis on Specific Skin Sites  

MedlinePLUS

... exactly as prescribed. • Do not apply high-concentration coal tar • ointments to the penis, scrotum or vulva, ... often prescribe topical treatments such as corticosteroids and coal tar first. However, phototherapy, oral retinoids and/or ...

203

Cold knife cone biopsy  

MedlinePLUS

Noller KL. Intraepithelial neoplasia of the lower genital tract (cervix, vulva): etiology, screening, diagnostic techniques, management. In: Lentz GM, Lobo RA, Gershenson DM, Katz VL, eds. Comprehensive Gynecology . 6th ...

204

Cysteine Dioxygenase 1 Is a Tumor Suppressor Gene Silenced by Promoter Methylation in Multiple Human Cancers  

E-print Network

cancers (breast, kidney, rectum, colon, stomach, skin, thyroid,thyroid, skin, kidney, bladder, lung, breast, ovary, uterus, cervix and vulva cancer.cancer. a Down Up b Colon Stomach Rectum Small Intestine Pancreas Liver c c Thyroid

2012-01-01

205

A Cholinergic Sensory-Motor Circuit Controls the Male Copulation Behavior in C. elegans  

E-print Network

elucidated in any animal. During mating, the C. elegans male cloaca is positioned over the hermaphrodite’s vulva as he attempts to insert his copulatory spicules repetitively. Rhythmic spicule thrusts cease when insertion is sensed. Circuit components...

Liu, Yishi

2012-07-16

206

Approved by the UHS Patient Education Committee 2/25/04 Last reviewed 07/23/13 Page 1 of 1  

E-print Network

. This tissue change may indicate a cervical wart (HPV) an irritation, or more seriously, dysplasia. What on the surface of the cervix, vagina, or vulva. After thorough inspection with the colposcope, your health

Yener, Aylin

207

Urination - painful  

MedlinePLUS

... atrophic vaginitis ) Herpes infection in the genital area Irritation of the vaginal tissue caused by bubble bath, perfumes, or lotions Vulvovaginitis , such as yeast or other infections of the vulva and vagina Other causes of painful urination include: ...

208

What Is Vulvar Cancer?  

MedlinePLUS

... Bartholin glands less often. Types of vulvar cancer Squamous cell carcinomas Most cancers of the vulva are squamous cell ... of skin cells. There are several subtypes of squamous cell carcinoma: The keratinizing type is most common, and usually ...

209

INTRODUCTION The question of how cells become different from one another  

E-print Network

cell spec- ification and differentiation (e.g. the anchor cell in the nematode vulva (Greenwald et al in a system that is amenable to genetic analysis, organ culture (Broadie et al., 1992) and cell manipu- lation

Broadie, Kendal S.

210

Bleomycin  

MedlinePLUS

... with other medications to treat head and neck cancer (including cancer of the mouth, lip, cheek, tongue, palate, throat, tonsils, and sinuses) and cancer of the penis, testicles, cervix, and vulva (the ...

211

Genetic Analysis of the Vulval Cell Lineages of 'Caenorhabditis elegans'.  

National Technical Information Service (NTIS)

The cell lineages of the nematode Caenorhabditis elegans are essentially invariant among individuals. Researchers have begun an attempt to understand the genetic specification of one particular cell lineage, that of the hermaphrodite vulva. During vulval ...

E. L. Ferguson

1985-01-01

212

Genital sores - female  

MedlinePLUS

... DC. Neoplastic diseases of the vulva. In: Lentz GM, Lobo RA, Gershenson DM, Katz VL, eds . Comprehensive ... Mosby Elsevier; 2012:chap 30. Eckert L, Lentz GM. Infections of the lower genital tract. In: Lentz ...

213

Lymphogranuloma venereum  

MedlinePLUS

... Churchill Livingstone; 2009:chap 180. Eckert LO, Lentz GM. Infections of the lower genital tract: vulva, vagina, ... toxic shock syndrome, endometritis, and salpingitis. In: Lentz GM, Lobo RA, Gershenson DM, Katz VL, eds. Comprehensive ...

214

Gumma  

MedlinePLUS

... 59(RR-12):1-110. Eckert LO, Lentz GM. Infections of the lower genital tract: Vulva, vagina, ... shock syndrome, HIV infections. In: Katz VL, Lentz GM, Lobo RA, Gershenson DM, eds. Comprehensive Gynecology. 5th ...

215

Chancroid  

MedlinePLUS

... Churchill Livingstone; 2009:chap 225. Eckert LO, Lentz GM. Infections of the lower genital tract: vulva, vagina, ... shock syndrome, HIV infections. In: Katz VL, Lentz GM, Lobo RA, Gershenson DM, eds. Comprehensive Gynecology . 5th ...

216

Genital Human Papillomavirus (HPV) Infection in Women  

MedlinePLUS

Genital Human Papillomavirus (HPV) Infection in Women What is HPV? HPV is human papillomavirus. It is the most common viral sexually transmitted infection ... the external genital areas (vulva). How common is HPV? HPV is very common. Most men and women ...

217

www.ext.vt.edu Produced by Communications and Marketing, College of Agriculture and Life Sciences,  

E-print Network

is delivered. The amniotic sac, or water bag, will appear at the vulva. The fetus starts to enter the birth birth. It is considered "retained" at 12 to 24 hours, but manually remov- ing the afterbirth

Liskiewicz, Maciej

218

Livestock Judging Suggestions.  

E-print Network

, leaner neck 4. Smaller jaw 5. Smoother shoulder 6. Stronger udder attachment 7. Better balanced udder 8. More productive udder 9. Smaller teats, more correct size teats 10. More correct udder development 11 . More well developed vulva 13 SWINE.... More well-developed vulva (gilt) -teats placed farther to the front 7. More well-developed, uniform-sized testicles (boar) SHEEP TERMS TERMS FOR BOTH BREEDING & MARKET SHEEP SKELETAL SIZE, STRUCTURE AND SOUNDNESS 1. Larger framed (taller, longer) 7...

Boleman, Larry L.

1986-01-01

219

The utilization of Dempster-Shafer probability theory in a veterinary diagnostic knowledge-based system on photosensitization in cattle due to the ingestion of a toxic plant  

E-print Network

, muzzle, vulva, escutcheon, and other lightly pigmented skin areas of cattle. Dermatologic lesions vary from mild erythema to edema, vesiculation, necrosis, and sloughing of the skin. There are two types of photosensitization, primly and secondary..., muzzle, vulva, escutcheon, and other lightly pigmented skin areas of cattle. Dermatologic lesions vary from mild erythema to edema, vesiculation, necrosis, and sloughing of the skin. There are two types of photosensitization, primly and secondary...

Gale, Jeffrey Wilson

2012-06-07

220

Investigation of a new approach for performing bilateral seminal vesiculectomies in bulls  

E-print Network

flagellated protozoan that inhabits the prepuce, glans penis, and possibly the terminal urethra of infected bulls. Trichomonads cause low rates of conception, early embryonic death, abortion, vulva-vaginitis, cervicitis, and pyometra in cattle. Trichomonads... flagellated protozoan that inhabits the prepuce, glans penis, and possibly the terminal urethra of infected bulls. Trichomonads cause low rates of conception, early embryonic death, abortion, vulva-vaginitis, cervicitis, and pyometra in cattle. Trichomonads...

Hooper, Richard Neil

2012-06-07

221

The effects of hand-rearing fallow deer in a captive environment  

E-print Network

to fourteen hours and average gestation length of 234 days (Willard, 1996). Does nearing parturition exhibit a distended abdomen, reddened vulva, and eniarged teats (Figure 3). Parturition and Cleaning. Between September 25, 1998, and November 2, 1998, ten... to fourteen hours and average gestation length of 234 days (Willard, 1996). Does nearing parturition exhibit a distended abdomen, reddened vulva, and eniarged teats (Figure 3). Parturition and Cleaning. Between September 25, 1998, and November 2, 1998, ten...

Healy, Allison Anne

2013-02-22

222

A behavioral catalogue of domestic cattle on grazing lands  

E-print Network

degrees with thrust; (c) cow addressing head thrust to side toward calf; and (d) cow addressing slight hooking thrust to conspecific 125 126 35 Bull investigating cows by sniffing and licking the vulva: (a) by walking up behind a grazing cow; and (b...'s legs . . . ~ ~ . ~ ~ ~ ~ ~ ~ ~ 151 xiv LIST OF FIGURES (continued) FIGURE Page 41 Courtship behaviors of cattle: (a) bull licking and sniffing the vulva of the cow while in the reverse parallel position; (b) bull licking cow while facing toward...

Antilley, Pamela Lind

2012-06-07

223

A Comparative analysis of selected broodmare management practices employed at Claiborne Farm  

E-print Network

operation is performed on most Claiborne mares. This is not unusual since size and shape of vulva is not an important selection criterion for Thoroughbred mares. Teasing is conducted at Claiborne in a traditional way. Uterine cultures are taken routinely... operation is performed on most Claiborne mares. This is not unusual since size and shape of vulva is not an important selection criterion for Thoroughbred mares. Teasing is conducted at Claiborne in a traditional way. Uterine cultures are taken routinely...

Green, Jerry M.

2012-06-07

224

A case study, artificial insemination versus natural breeding at Overland Farms, Ft. Worth, Texas  

E-print Network

), including tail raising, squatting, urinating and winking, or by rectal palpation, both the mare and stallion were prepared for breeding. Preparation of the mare for natural service consisted of wrapping the tail and washing the vulva, with cotton soaked...), including tail raising, squatting, urinating and winking, or by rectal palpation, both the mare and stallion were prepared for breeding. Preparation of the mare for natural service consisted of wrapping the tail and washing the vulva, with cotton soaked...

Migues, Loraine C.

2012-06-07

225

Veterinary Science: Glanders Experiments - Tuberculine Experiments - Lump Law [i.e. jaw] of Cattle - Notes on Parasites - Texas Fever Experiments - Device for Destroying Ticks  

E-print Network

cattle ticks were noticed on abdomen, skin normal, discharge of bloody urine from vulva and bloody froth from nostril, Visible mucus membranes con- gested and dark. Incision through skin and muscles and bloody and connective tissue, yellowish in color... cattle ticks were noticed on abdomen, skin normal, discharge of bloody urine from vulva and bloody froth from nostril, Visible mucus membranes con- gested and dark. Incision through skin and muscles and bloody and connective tissue, yellowish in color...

Francis, M.

1894-01-01

226

Artificial Stimulation of Cephalic Cholinergic Sensory Neurons Induces Mating-Like Motor Responses in Male Caenorhabditis elegans  

E-print Network

cycle from egg to sexually mature adult. There are two sexes; a larger hermaphrodite (959 somatic cells) capable of self- fertilization, which possesses a vulva and two gonadal arms, in which both first spermatogenesis of approximately 300 sperm... experiments in C. elegans, because it abolishes the natural tendency of the worm to flee high-intensity illumination [10]. The male and hermaphrodite differ in their gross morphology. Hermaphrodites have a centrally-located vulva connected to two gonadal...

Midkiff, James

2012-12-06

227

The relationship between lymphatic cysts and lymphatic lacunae in the endometrium of mares  

E-print Network

in serum progesterone concentration to & 0. 5 ng/ml and an increased blood concentration of estrogen secreted by the preovulatory follicle (35). Physiologic changes during estrus include an enlarged, swollen vulva with loose labial folds (49... in serum progesterone concentration to & 0. 5 ng/ml and an increased blood concentration of estrogen secreted by the preovulatory follicle (35). Physiologic changes during estrus include an enlarged, swollen vulva with loose labial folds (49...

Darling, Ralph Edward

2012-06-07

228

The role of the bull's vomeronasal organ in estrous determination  

E-print Network

) were administered intramuscularly. Standing heat occurred 8-14 hrs later. It was judged that cows were in standing heat when they displayed signs of standing while mounted . Other indications included tail ex- tension, swollen vulva, vaginal..., are swelling of the vulva, tail deviation and a characteristic posture. These signs were also noticable to the ob- servers at various times during the trials. In addition, cervical- vaginal mucus, secreted by cows in heat, has also been shown to elicit a...

McGrath, Thomas James

2012-06-07

229

Non-surgical collection of ovine embryos  

E-print Network

solution li fi- ' 17 for cold sterilization 1 hour before the collections. The ewes were restrained in dorsal recumbency in a cradle that allowed them to be tilted 30 degrees in either direction. Once restrained, wool around the vulva was clipped... solution li fi- ' 17 for cold sterilization 1 hour before the collections. The ewes were restrained in dorsal recumbency in a cradle that allowed them to be tilted 30 degrees in either direction. Once restrained, wool around the vulva was clipped...

Coonrod, Scott Alexander

2012-06-07

230

Cyclic variation in some electrolytes and the water content of ovine cervico-vaginal mucus  

E-print Network

laterally on the 10 area surrounding the vulva. This prevented contamination from external debris. The catheter was passed to the os cervix and all the mucus possible was aspirated. Immediately after each collection, the catheter was sealed by placing a... laterally on the 10 area surrounding the vulva. This prevented contamination from external debris. The catheter was passed to the os cervix and all the mucus possible was aspirated. Immediately after each collection, the catheter was sealed by placing a...

Connor, Jack Seale

2012-06-07

231

Effects of population density on estrous cycles of two-year old quarter horse mares  

E-print Network

and McKenzie, 1941; Roberts, 1971). As estrus progresses and ovulation nears there is an increased congestion of the vagina and cervix. The cervical mucosal flow becomes copious and decreases in viscosity, as the cervix and vulva become relaxed... rear quarters towards the stallion, elevate her tail, squat, urinate, and "wink" her vulva. One aspect of estrous behavior that has been the subject of controversy is whether or not mares engage in the homo- sexual behavior of mounting. Some...

Burke, Daniel John

2012-06-07

232

Meteorological factors affecting the length of the postestrus-preovulatory period in the dairy cow  

E-print Network

- preovulatory interval. Estrus was detected by visual observation of the animal and the use of K-Mar Heatmount detectors. Signs consid- ered to be indications of estrus were raised lip, raised tail, vaginal or cervical mucus, enlarged vulva, less rumination...- preovulatory interval. Estrus was detected by visual observation of the animal and the use of K-Mar Heatmount detectors. Signs consid- ered to be indications of estrus were raised lip, raised tail, vaginal or cervical mucus, enlarged vulva, less rumination...

Williams, Robert Lawton

2012-06-07

233

Everything But: Exploring Definitions of Sexual Outercourse Among Undergraduate Students  

E-print Network

making love? pregnancy? (p.1380). of the vagina and avoiding (p.1380). getting any semen into the vulva or vagina?anal and oral intercourse is to be avoided? (p.1380). 6 Bolin&Whelehan 1999 ?Interfemoral intercourse? No No No Yes....? avoid pregnancy? thighs and up against her ??use the proper protection (p.111). lubricated vulva and clitoris. if you?re unsure of your As the couple is in this partner?s health status (p.110). position, the male...

Menn, Mindy Alison

2011-02-22

234

Endometrial cytology in the mare  

E-print Network

bacteria. Due to the nature of the anatomy of the reproductive tract of the mare and the presence of both resident and transient microflora on the external genitalia (i. e. vulva, urethral orifice, clitoral sinus, and posterior vagina), it is difficult... bacteria. Due to the nature of the anatomy of the reproductive tract of the mare and the presence of both resident and transient microflora on the external genitalia (i. e. vulva, urethral orifice, clitoral sinus, and posterior vagina), it is difficult...

Ley, William Bruce

2012-06-07

235

Embryo collection and attempted replacement in the mare  

E-print Network

. To prepare for insemination, the mare's vulva, perineal region, and buttocks were washed three times with Betadine Veterinary Surgical Scrub (Purdue Frederick Co. , Norwalk, Conn. ) and then thoroughly rinsed with water. This was done to reduce the chance.... To prepare for insemination, the mare's vulva, perineal region, and buttocks were washed three times with Betadine Veterinary Surgical Scrub (Purdue Frederick Co. , Norwalk, Conn. ) and then thoroughly rinsed with water. This was done to reduce the chance...

Beach, Jane Salisbury

2012-06-07

236

Ovarian activity, circulating hormones and sexual behavior in the cat: relationships during pregnancy, parturition, lactation and the postpartum estrus  

E-print Network

her to scr atch and spit. If mounted, the female shows full spinal flexion, wrapping her tail tightly under the perineum. Males often turn abruptly away after scenting the anestrous vulva, possibly a repelling mechanism. Immature females react less... her to scr atch and spit. If mounted, the female shows full spinal flexion, wrapping her tail tightly under the perineum. Males often turn abruptly away after scenting the anestrous vulva, possibly a repelling mechanism. Immature females react less...

Schmidt, Patricia Mary

2012-06-07

237

Identifying and Mapping Parallel Mutations of GAR-3  

E-print Network

. elegans male mating behavior consists of multiple sensory and motor steps. One of these steps is the insertion of the male sex organ (called the spicule) into the vulva of his hermaphroditic mate. A neuromuscular circuit, consisting of spicule... muscle contracting, and consequently male worms display mating behavior (Liu et al., 2007). Experimental basis Wild type male C. elegans mate by inserting their spicules into a hermaphrodite?s vulva. Arecoline will make males stick their spicules...

Prompuntagorn, Christopher

2009-06-09

238

The free amino acid content of ovine cervicovaginal mucus  

E-print Network

was taken into the surgery room and her neck placed between two upright metal bars. in this restrained position, the vulva was spread with the fingers and cervicovaginal mucus was aspirated from the anterior vagina with a plastic insemina- tion catheter... was taken into the surgery room and her neck placed between two upright metal bars. in this restrained position, the vulva was spread with the fingers and cervicovaginal mucus was aspirated from the anterior vagina with a plastic insemina- tion catheter...

Woodward, Thomas Lee

2012-06-07

239

Vaginal resistance values as related to estrus and early pregnancy in the ewe  

E-print Network

only resistance from the area of restriction to the vulva. Such a probe, however, would require sep- arate calibration of resistance values for young animals since the conduction area on the probe would have been reduced by 50 percent. Both... only resistance from the area of restriction to the vulva. Such a probe, however, would require sep- arate calibration of resistance values for young animals since the conduction area on the probe would have been reduced by 50 percent. Both...

Beverly, John Richard

2012-06-07

240

The value of tan lines: vulvar melanoma and ultraviolet rays.  

PubMed

Recreational sun exposure of the general population has increased. There is less clothing on the beaches, increased accessibility to tropical beaches, and increased use of artificial suntanning equipment. The vulva, traditionally, has been protected from sun exposure. In this age of nude sunbathing, particularly within the confines of a tanning bed, it is interesting to ponder whether such exposure would affect the incidence of melanoma of the vulva. PMID:11466488

Isenberg, A; Paul Shackelford, D

2001-06-01

241

Clinical, genetic, and pathological features of male pseudohermaphroditism in dog  

PubMed Central

Male pseudohermaphroditism is a sex differentiation disorder in which the gonads are testes and the genital ducts are incompletely masculinized. An 8 years old dog with normal male karyotype was referred for examination of external genitalia abnormalities. Adjacent to the vulva subcutaneous undescended testes were observed. The histology of the gonads revealed a Leydig and Sertoli cell neoplasia. The contemporaneous presence of testicular tissue, vulva, male karyotype were compatible with a male pseudohermaphrodite (MPH) condition. PMID:21255434

2011-01-01

242

A Comparative ID Migraine™ Screener Study in Ophthalmology, ENT and Neurology OutPatient Clinics  

Microsoft Academic Search

Migraine is more likely to be misdiagnosed in patients with comorbid diseases. Not only primary care physicians, but also specialists might misdiagnose it due to the lack of diagnostic criteria awareness. The ID migraine test is a reliable screening instrument that may facilitate and accelerate migraine recognition. This study aimed to compare the prevalence and characteristics of migraine in a

M Erta?; B Baykan; D Tuncel; M Gökçe; F Gökçay; H ?irin; O Deniz; V Öztürk; F ?diman; N Karl?; M Zarifo?lu; N Y?ld?z; A Siva; S Saip; B Göksan; F Ak; U Aluçlu; T Duman; ?M Melek; S Bulut; S Berilgen

2009-01-01

243

Spirometra (Pseudophyllidea, Diphyllobothriidae) severely infecting wild-caught snakes from food markets in Guangzhou and Shenzhen, Guangdong, China: implications for public health.  

PubMed

Sparganosis is a zoonotic disease caused by the spargana of Spirometra, and snake is one of the important intermediate hosts of spargana. In some areas of China, snake is regarded as popular delicious food, and such a food habit potentially increases the prevalence of human sparganosis. To understand the prevalence of Spirometra in snakes in food markets, we conducted a study in two representative cities (Guangzhou and Shenzhen), during January-August 2013. A total of 456 snakes of 13 species were examined and 251 individuals of 10 species were infected by Spirometra, accounting for 55.0% of the total samples. The worm burden per infected snake ranged from 1 to 213, and the prevalence in the 13 species was 0?96.2%. More than half (58.1%) of the spargana were located in muscular tissue, 25.6% in subcutaneous tissue, and 16.3% in coelomic cavity. The results indicated that Spirometra severely infected snakes in food markets in Guangzhou and Shenzhen, implying that eating snakes has great health risk and improper cooking methods may increase the risk of Spirometra infection in humans in China. Additional steps should be considered by the governments and public health agencies to prevent the risk of snake-associated Spirometra infections in humans. PMID:24558340

Wang, Fumin; Li, Weiye; Hua, Liushuai; Gong, Shiping; Xiao, Jiajie; Hou, Fanghui; Ge, Yan; Yang, Guangda

2014-01-01

244

Comparison of molecular abnormalities in vulvar and vaginal melanomas.  

PubMed

Malignant melanoma of the vulva and vagina is relatively uncommon and accounts for <5% of all melanomas in women. The aim of our study was to establish the biological properties and evaluate potential therapeutic targets in these tumors. We collected a series of 65 cases from three centers and re-evaluated the tumor tissue for predominant growth pattern (superficial spreading, nodular, and mucosal lentiginous) and tumor thickness. KIT (CD117) expression was detected immunohistochemically. In addition, tumors were screened for BRAF, NRAS, and KIT mutations by PCR and DNA sequencing as well as for KIT amplifications by fluorescence in situ hybridization. None of the cases contained BRAF mutations. NRAS mutations and KIT amplifications were detected in similar frequency (?12%) in tumors of the vulva and vagina. In contrast, KIT mutations were present in 18% of primary melanomas of the vulva, but in none of the tumors arising in the vagina. Moderate or strong KIT protein expression was detected in 30 cases, including all tumors with KIT mutations and 6 of the 7 with KIT amplifications. In conclusion, BRAF mutations are virtually absent in melanomas originating from the vulva or vagina, whereas NRAS mutations and KIT amplifications occur in both locations. KIT mutations appear to be specific for melanomas of the vulva, suggesting that in spite of the anatomic proximity, the development of vulvar and vaginal melanomas involves different molecular alterations which may be targeted by novel treatment approaches. PMID:24603591

Aulmann, Sebastian; Sinn, Hans P; Penzel, Roland; Gilks, C Blake; Schott, Sarah; Hassel, Jessica C; Schmidt, Dietmar; Kommoss, Friedrich; Schirmacher, Peter; Kommoss, Stefan

2014-10-01

245

The SynMuv genes of Caenorhabditis elegans in vulval development and beyond  

PubMed Central

For a nonessential diminutive organ comprised of only 22 nuclei, the Caenorhabditis elegans vulva has done very well for itself. The status of the vulva as an overachiever is in part due to its inherent structural simplicity as well as to the intricate regulation of its induction and development. Studies over the past twenty years have shown the vulva to be a microcosm for organogenesis and a model for the integration of complex signaling pathways. Furthermore, many of these signaling molecules are themselves associated with cancer in mammals. This review focuses on what is perhaps the most intriguing and complex story to emerge from these studies thus far, the role of the Synthetic Multivulval (SynMuv) genes in controlling vulval cell-fate adoption. Recent advances have led to a greater mechanistic understanding of how these genes function during vulval development and have also identified roles for these genes in diverse developmental processes. PMID:17434473

Fay, David S.; Yochem, John

2007-01-01

246

Sinus Headache or Migraine  

MedlinePLUS

... mail address below. "Sinus Headache" or Migraine Susan Hutchinson, MD Key Points: Migraine is commonly misdiagnosed as ... of failed headache treatment and disability! By Susan Hutchinson, MD, Director, Orange County Migraine & Headache Center, Irvine, ...

247

Iatrogenic Cushing's Disease in a Boy after Misdiagnosis of Salt-Losing Virilizing Adrenal Hyperplasia: Impaired Metyrapone Response with Failure of Catch-Up Growth  

ERIC Educational Resources Information Center

A boy misdiagnosed as having the sodium-losing form of virilizing adrenal hyperplasia was treated with large doses of glucocorticoids and mineralocorticoids from the newborn period until he was more than 4 years of age. (Author)

Mendilaharzu, Hernan; And Others

1973-01-01

248

Hereditary Hemochromatosis (For Parents)  

MedlinePLUS

... causing serious health problems. Iron is a trace mineral that plays a vital role in the body. ... misdiagnosed as chronic hepatitis, other forms of diabetes, Alzheimer's disease, iron deficiency, gallbladder illness, menstrual problems, thyroid ...

249

75 FR 4568 - Agency Forms Undergoing Paperwork Reduction Act Review  

Federal Register 2010, 2011, 2012, 2013

...examine the connection between ALS and other motor neuron disorders that can be confused with ALS, misdiagnosed as ALS, and...ATSDR) in March 2006 to discuss surveillance of selected autoimmune and neurological diseases, it was decided to develop a...

2010-01-28

250

Quit Obsessing!  

ERIC Educational Resources Information Center

Asserts the obsessive-compulsive disorder is often misdiagnosed in children and adolescents; describes characteristics of obsessive-compulsive disorder; differentiates between normal and abnormal obsessions; suggests ways teachers can help students diagnosed with the disorder. (PKP)

Schlozman, Steven C.

2002-01-01

251

Calibration of sonographic gel probe covers for in-vivo mechanical testing  

E-print Network

Cervical insufficiency is a condition in pregnancy in which the cervix asymptomatically dilates in the absence of uterine contractions, resulting in a spontaneous preterm delivery. The condition is often misdiagnosed and ...

Charenkavanich, Panasaya

2005-01-01

252

Questions for Your Doctor: Your First Visit  

MedlinePLUS

... cancer, be happy, but also be aware that testicular cancer is misdiagnosed as epididymitis or something similar almost ... kill you? What is the cure rate for testicular cancer? Am I going to die or be seriously ...

253

The emergence of mecC methicillin-resistant Staphylococcus aureus  

E-print Network

The report of methicillin-resistant Staphylococcus aureus (MRSA) encoding a divergent mecA gene in 2011 was highly significant. This homologue, designated mecC, poses diagnostic problems with the potential to be misdiagnosed as methicillin...

Paterson, Gavin K.; Harrison, Ewan M.; Holmes, Mark A.

2013-11-12

254

Recognizing and Handling Calving Problems  

E-print Network

contracts, the allantochorion water bag passes through the cervix and often ruptures. In about half of normal births the allantochorion mem- brane passes through the vagina and reaches the vulva 4 Figure 1. Obstetrical chains and handles used in forced... with the allantochorion which is a darker color. Appearance of the amnion or feet beginning to protrude through the vulva marks the beginning of the delivery stage. Ordinarily, birth occurs within 30 minutes to 4 hours after the amnion or feet are first visible. Although...

Beverly, John R.

2003-05-28

255

Improving Reproductive Efficiency in Angora Goats.  

E-print Network

or around the vulva. (It is important that blood stains be distinguished from urine or fecal stains.) However, some goats that have aborted will not be identifiable by this procedure. A second form of loss is due to repeat aborters, i.e., the same does... or around the vulva. (It is important that blood stains be distinguished from urine or fecal stains.) However, some goats that have aborted will not be identifiable by this procedure. A second form of loss is due to repeat aborters, i.e., the same does...

Shelton, Maurice; Groff, Jack

1984-01-01

256

The cultural aspects of Aztec lexicon in Mexican Spanish  

E-print Network

' are chiche 'teat' and ~etaca (stand. def. 'trunk' ). Euphemisms for the vulva are camote (stand. def. 'sweet potato'1, ~cha ote (pea -shaped fruit), ~och(to ue (stand. def. 'turtle' ), and tamal. Euphemisms for the 'posterior' and 'anus' of the body a...' are chiche 'teat' and ~etaca (stand. def. 'trunk' ). Euphemisms for the vulva are camote (stand. def. 'sweet potato'1, ~cha ote (pea -shaped fruit), ~och(to ue (stand. def. 'turtle' ), and tamal. Euphemisms for the 'posterior' and 'anus' of the body a...

Powell, James Woodward

2012-06-07

257

Effect of age and concentration of sperm on conception rate and litter size in swine  

E-print Network

weight wc. s borne by the female. Clawing at the shoulders or digi 0il stirriulction of thc clitoris were sometimes helpful xn ob- taining the mountable stage. At this stage of estrus the vulva is frequently less swollen, though still enlarged and more... weight wc. s borne by the female. Clawing at the shoulders or digi 0il stirriulction of thc clitoris were sometimes helpful xn ob- taining the mountable stage. At this stage of estrus the vulva is frequently less swollen, though still enlarged and more...

Licon Quintero, Mario Alberto

2012-06-07

258

Assisting Difficult Calving  

E-print Network

when fetal parts enter the birth canal and stimulate the abdominal press. The first water bag (chorioallantoic sac) usually rup- tures early in stage 2. The second water bag (am- niotic sac) is often forced through the vulva after the cow has been... in labor for a short time. Deliv- ery should be completed within 2 hours after the appearance of the amniotic sac at the vulva. Stage 2 labor may last from 30 minutes to 4 hours. Assisting Difficult Calving The delivery of the fetus is eased by the use...

Faries Jr., Floron C.

2006-12-20

259

Early pregnancy diagnosis by vaginal pressures and cervical smears in the bovine  

E-print Network

- seminating catheter and a clean dry glass vaginal speculum. Care was exercised to avoid any mucous contamira tion from ths vaginal wall or the vulva. A head lamg was used in collecting the mucus to illuminate the cervt. cal opening and every precaution...- seminating catheter and a clean dry glass vaginal speculum. Care was exercised to avoid any mucous contamira tion from ths vaginal wall or the vulva. A head lamg was used in collecting the mucus to illuminate the cervt. cal opening and every precaution...

Ghannam, Samir A. M

2012-06-07

260

Embryo collection and transfer in the dog  

E-print Network

, is described as the onset of follicular development, the appearance of a bloody discharge from the vagina and swelling of the vulva. Its duration ranges for 3-16 days usually averaging 9 days (Stabenfeldt and Shille, 1977). A vagina) smear shows pro... of estrus, including tail deflection, elevation of the vulva and willingness to stand and be mounted by the male, was designated Day 1 of estrus. At onset of estrus females were artificially insemina'ted using fresh semen collected from an intact male...

Kinney, Gail Marie

2012-06-07

261

Plasma steroid concentrations following conception in the mare  

E-print Network

oxide. Glassware was sterilized in an oven at 150 C for 24 h. The rectum was evacuated of feces and ovaries were palpated for follicular activity prior to flushes. The vulva and rectal area was washed a minimum of two times, with a 5' betadine scrub.... The collection cylinder (a 1 liter graduated cylinder for the first and second aliquot and 1 liter glass bottle for the third aliquot) was positioned below the vulva of the mare, the clamp on the recovery tube was opened and the fluid was allowed to drain out...

Pipkin, John Louis

2012-06-07

262

Estrous cycle detection, superovulation and interspecies embryo transfer in Iranian Red Sheep  

E-print Network

, was inserted through the vulva into the vagina and placed at the anterior end of vagina with the help of a cylindrical plastic speculum. The sponge was placed in the animal at an unknown day of the cycle (somewhere in the luteal phase). The sponge remained..., was inserted through the vulva into the vagina and placed at the anterior end of vagina with the help of a cylindrical plastic speculum. The sponge was placed in the animal at an unknown day of the cycle (somewhere in the luteal phase). The sponge remained...

Shrestha, Sunder Prasad

2012-06-07

263

Ovulation in the collared peccary as documented by laparoscopy  

E-print Network

with an unreceptive female. Using her short we 1 I muscled tail (about 3 cm long) she can effectively cover her vulva if she is not receptive. In his study on the social behavior of the collar ed peccary, Sowls (1974) found that among receptive adult peccaries... with an unreceptive female. Using her short we 1 I muscled tail (about 3 cm long) she can effectively cover her vulva if she is not receptive. In his study on the social behavior of the collar ed peccary, Sowls (1974) found that among receptive adult peccaries...

Coscarelli, Kenneth Paul

2012-06-07

264

A professional internship with Texas Breeders Service  

E-print Network

). This injection blocks the rectal contractions and anal sphincter muscle (8). The vulva lips are spread and a catheter is inserted through the vagina into the os cervix. Once in the cervix the chemise cover is retracted until it is ruptured by the catheter...). This injection blocks the rectal contractions and anal sphincter muscle (8). The vulva lips are spread and a catheter is inserted through the vagina into the os cervix. Once in the cervix the chemise cover is retracted until it is ruptured by the catheter...

McKemie, Jack Furman

2012-06-07

265

Assisting Difficult Calving (Spanish)  

E-print Network

etapa. El segundo saco de fluidos (saco amni?tico) normalmente es forzado a trav?s de la vulva despu?s de iniciada la labor de parto. El *Professor and Extension Program Leader for Veterinary Medicine and Extension Associate?Animal Science, Texas... presi?n abdominal por dos horas sin presentaci?n del becerro, la vaca deber? ser examinada. Si la vaca presenta el saco amni?tico a trav?s de la vulva y no ha parido en dos horas, se deber? ayudar con el parto. Una vez que las primeras partes del...

Faries Jr., Floron C.; Villarino, Mario A.

2009-03-05

266

Study of perineal patterns of four species of Meloidogyne (Nematoda:Heteroderoidea) using scanning electron microscopy  

E-print Network

, except that in M. ~ha la a raised and clearly differentiated tail area was always observed. M. ~fco it hibited tiy a high d I a h. The inner st 1- tions around the vulva and up the tail area formed a distinctive pear shape. The lateral field... was greater in Race 1 than in Race 3. In development studies of fou? species, appearance of pattern 16, 20, 28-30 and 50-52 days after inoculation of hosts exhibited considerable changes in vulval widths, distance from vulva to anus and extent of pattern...

Khan, Zainab Najafali

2012-06-07

267

Effect of excitability measured by blood glucose level, and degree of fatness on conception rate in breeding beef cows  

E-print Network

of intravenously in/ected pitocin. It was observed that tetsnic uterine contractions were caused at various stages ef the estrous cycle by massage of the vulva, massage of the cervi. x, a ccssbination of the two, or by natural mating. Intravenous in... of intravenously in/ected pitocin. It was observed that tetsnic uterine contractions were caused at various stages ef the estrous cycle by massage of the vulva, massage of the cervi. x, a ccssbination of the two, or by natural mating. Intravenous in...

Johnston, Marvin Glenn

2012-06-07

268

Quantitative and qualitative evaluation of the bacterial flora of stallion semen  

E-print Network

by holding a cup under the vulva of the mare and subsequently under the glans penis of the stallion as he withdraws to collect the ejaculate that flows out. An alternate method is to "milk" the 19 residual semen from the urethra after the stallion has... by holding a cup under the vulva of the mare and subsequently under the glans penis of the stallion as he withdraws to collect the ejaculate that flows out. An alternate method is to "milk" the 19 residual semen from the urethra after the stallion has...

Simpson, Russell Bruce

2012-06-07

269

A study on the effects of cervical mucus of synchronized cows on the behavior of bull spermatozoa  

E-print Network

for estrus twice daily, St30 to 7:00 a. m. and 5:15 to 5:45 p. m. The following criteria were used: estrus was characterized by the presence of a mature follicle (15 to 20 mm in diameter) in conjunction with increased uterine tone, edema of the vulva..., mucous discharge from the vulva, nervousness and attempts to th; ~d' 'd d h ~ d when the cow stood to be mounted; silent estrus was considered to have occurred when no behavioral signs of estrus were observed, even though the other signs were present...

Cal, Guillermo Luis

2012-06-07

270

Fixed time artificial insemination of sheep using cervical and intrauterine insemination techniques  

E-print Network

approximately 3 feet tall. The ewe's flanks were then rested on the bar and the ewe held in place. The vulva was wiped clean and a lighted vaginal speculum, lubricated with a water based lubricant, was inserted into the vagina. The external cervical os... approximately 3 feet tall. The ewe's flanks were then rested on the bar and the ewe held in place. The vulva was wiped clean and a lighted vaginal speculum, lubricated with a water based lubricant, was inserted into the vagina. The external cervical os...

Bell, James H

2012-06-07

271

The Impact of Genital Self-Image on Gynecological Exam Behaviors of College-Aged Women  

E-print Network

in New Orleans, or why stepwise is the devil. Finally, thank you to Dr. Debby Herbenick, a fabulous mentor for all things vulva. I admire your expertise and willingness to offer your time and knowledge, all the way from Indiana University, to my work... in New Orleans, or why stepwise is the devil. Finally, thank you to Dr. Debby Herbenick, a fabulous mentor for all things vulva. I admire your expertise and willingness to offer your time and knowledge, all the way from Indiana University, to my work...

DeMaria, Andrea Laine

2012-07-16

272

Helminthic parasites of water snakes, Natrix spp. (Serpentes: Colubridae), from southeast Texas  

E-print Network

is the distance from mid-acetabulum to the anterior 'extremity. Two DeMann's formulas are used in nematode descriptions, the ratio to total length of 1) the distance of the vulva from the anterior extremity and 2) the length of the esophagus. Wright and Wright... is the distance from mid-acetabulum to the anterior 'extremity. Two DeMann's formulas are used in nematode descriptions, the ratio to total length of 1) the distance of the vulva from the anterior extremity and 2) the length of the esophagus. Wright and Wright...

Guidry, Edmund Vaughn

2012-06-07

273

Liver Flukes: the Common Fluke (Distomum hepaticum). A New Species (Distomum texanicum).  

E-print Network

of abdominal sucker, alway~ recurved. Vulva very small, situated at the side of the male orlfice or a little behind. Eggs brown or greenish, ovoid; length from 0.130 to 0.145mm; width from 0.070 to 0.090mm (Weuman). Copied from .'Animal Parasites of Sheep... of abdominal sucker, alway~ recurved. Vulva very small, situated at the side of the male orlfice or a little behind. Eggs brown or greenish, ovoid; length from 0.130 to 0.145mm; width from 0.070 to 0.090mm (Weuman). Copied from .'Animal Parasites of Sheep...

Francis, M. (Mark)

1891-01-01

274

A comparison of conception rates between artificial insemination and natural breeding of mares  

E-print Network

and their vulvas were washed with soap and water and then rinsed and dried. Semen was collected from each stallion before the season to determine total volume and sperm concentra- tion and motility. Since breedings were natural, the semen used for each breeding... and their vulvas were washed with soap and water and then rinsed and dried. Semen was collected from each stallion before the season to determine total volume and sperm concentra- tion and motility. Since breedings were natural, the semen used for each breeding...

Miller, John Arthur

2012-06-07

275

The effect of postbreeding uterine lavage on pregnancy rate in mares  

E-print Network

of bacteria and fungi on the vulva, within the vestibule and vagina, and possibly the cervix (2). The mare's uterus is the. efore exposed to a wide variety of infectious agents at the time of breeding. Young, healthy mares are usually able to overcome... of bacteria and fungi on the vulva, within the vestibule and vagina, and possibly the cervix (2). The mare's uterus is the. efore exposed to a wide variety of infectious agents at the time of breeding. Young, healthy mares are usually able to overcome...

Brinsko, Steven Patrick

2012-06-07

276

Follicular changes and reproductive hormones in captive white- tailed deer during the breeding season  

E-print Network

(heat), she was usually less active than normal and would sometimes be difficult to transfer into the holding pen. Once a doe was transferred to the buck's pen, the buck immediately approached her and began to nose and lick her vulva and tarsal... (heat), she was usually less active than normal and would sometimes be difficult to transfer into the holding pen. Once a doe was transferred to the buck's pen, the buck immediately approached her and began to nose and lick her vulva and tarsal...

Biediger, Timothy Gerard

2012-06-07

277

Determining Pregnancy in Cattle  

E-print Network

in the sexual cycle. Figure 2 is a general diagram of the reproductive tract. The vulva is the external portion of the repro- ductive tract and can be seen as two prominent lips. Its size may vary with the animal?s age and be- tween breeds. Brahman...-influenced females usually have a larger vulva than do cattle of English and European breeds. Figure 2 (right to left) shows the next portion of the tract: the vagina. It serves as a receptacle for se- men during natural mating, is a thin-walled structure...

Beverly, John R.; Sprott, L. R.; Carpenter, Bruce B.

2008-12-16

278

Effects of the mycotoxin penicillic acid on electrogenic sodium transport  

E-print Network

is produced by five Fusarium species; Pathological effects of this mycotoxi n include swel 11 ng and edema of the vulva, prolapse of the vagina, enlargement of the uterus, atrophy of the ovaries and testicles, enlargement of the mammary glands, and abor... is produced by five Fusarium species; Pathological effects of this mycotoxi n include swel 11 ng and edema of the vulva, prolapse of the vagina, enlargement of the uterus, atrophy of the ovaries and testicles, enlargement of the mammary glands, and abor...

Wilczynski, Teresa Anne

2012-06-07

279

The Screw-worm.  

E-print Network

, flank, or just behind the udder of cows. They often occur in the vulva: of fresh cows, especially if there has been a retention of the placenta or afterbirth. Young calves are almost invariably affected in the navel and often in the mouth, causing..., flank, or just behind the udder of cows. They often occur in the vulva: of fresh cows, especially if there has been a retention of the placenta or afterbirth. Young calves are almost invariably affected in the navel and often in the mouth, causing...

Francis, M. (Mark)

1890-01-01

280

Isolation and chemical studies of an abortifacient from Gutierrezia spp  

E-print Network

Pregnant Goats Goat No. Wt. Da Dose No. of Results m i/ Da 8 45. 4 6. 0 11 Died, signs of 1m~ abortion 38, 0 3, 7 5 e Bloody discharge from vulva. Died 3 days later. Minute hemorrhagss in uterus. 75 40. 5 3. 6 11 Aborted, died 3 days later... Pregnant Goats Goat No. Wt. Da Dose No. of Results m i/ Da 8 45. 4 6. 0 11 Died, signs of 1m~ abortion 38, 0 3, 7 5 e Bloody discharge from vulva. Died 3 days later. Minute hemorrhagss in uterus. 75 40. 5 3. 6 11 Aborted, died 3 days later...

Shaver, Ted Neil

2012-06-07

281

The influence of level of energy intake on reproductive performance of gilts  

E-print Network

, Calculated according to 4 Nineral miz composed of methods of Fraps (1946), 1. $ lb' bone meal and 0. $ lb. salt. visible signs of estrus by examinations of the vulvas for increased ~ ise and vasoularity until they reached 120 days of age. onoe this age..., Calculated according to 4 Nineral miz composed of methods of Fraps (1946), 1. $ lb' bone meal and 0. $ lb. salt. visible signs of estrus by examinations of the vulvas for increased ~ ise and vasoularity until they reached 120 days of age. onoe this age...

Thomas, William Belton

2012-06-07

282

Effect of ureaplasma upon the development of zona pellucida intact ovine embryos  

E-print Network

in dairy cattle (25). Ureaplasma colonize primarily the vulva and vagina and are rarely found in the upper reproductive tract of normal sheep, but commonly occur in the respiratory tract of cattl e. This hol ds true for both pathogenic and nonpathogenic... of the hei fers was found to carry ureaplasma in the vulva for up to 7 months (22). The localized vulvar infection can be a possible source of recontamination of the uterus at each breeding via mechanical tr ansmi ssion on the insemination pi pette...

Kapp, Jennifer Lynne

2012-06-07

283

Bacteriological study of the uterus of cows during estrus  

E-print Network

and Bryner (1952), and Qxntsr st al. (1955), respectively. Be- sides, it ls easy to sterilize and very easi. ly manipulated ~ Thirty uterine samples were obtained using this instru- ment ~ To obtain the safoples ths lips of the vulva were sepa- rated... and Bryner (1952), and Qxntsr st al. (1955), respectively. Be- sides, it ls easy to sterilize and very easi. ly manipulated ~ Thirty uterine samples were obtained using this instru- ment ~ To obtain the safoples ths lips of the vulva were sepa- rated...

Couto, Edalmo Souza

2012-06-07

284

The induction of parturition in the mare with prostaglandin F??  

E-print Network

. Rossdale et al ~ (1976) reported that fluprostenol injected into nine mares at term produced nine viable foals vd. thin 4 hr after injection, None of the mares showed any signs of imminent parturition. The vulvas of the mares were contracted...'s reproductive tract were utiliz- ed as criteria for the decision to assist the mare, If progress was not noted withi~ $0 minutes after both forelegs of the foal were visible externally through the mare' s vulva~ the decision was made to physically remove...

Klem, Michael Edward

2012-06-07

285

Determining Pregnancy in Cattle.  

E-print Network

the urethral orifice, from this point to the vagina exterior acts as a common passageway for urine and passage of young at birth. The vagina has the feeling of a thin-walled organ similar to that of the uterus. The vulva is the external portion... the urethral orifice, from this point to the vagina exterior acts as a common passageway for urine and passage of young at birth. The vagina has the feeling of a thin-walled organ similar to that of the uterus. The vulva is the external portion...

Sorensen, A. M. Jr.; Beverly, J. R.

1968-01-01

286

The recognition of certain parasitic worms in tissue sections  

E-print Network

)& posterior esophageal region (0) ~ region of the vulva (D), anterior body region (X), and the posterior body region (P) ~ Whipworms (Triohurls ~vul is) were colleoted from a two year old mals dog (knees& 16226) which died ?1th a severe hookworm infection... and pleuritis, Soot iona of the female (2) were made from the anterior ssopha goal region (B)& middle esophageal region (C& D)& posterior esophageal region {X) & region of the vulva (P) ~ anterior 'body region (G), middle body region (H), and the posterior...

Payne, Bobby Joe

2012-06-07

287

A study of some factors affecting reproductive performance in gilts  

E-print Network

. All gilts were checked daily for visible signs of onset of heat by examination of the vulvas for increased size and vascularity until they were 120 days of age. After that time, they were checked twice daily, early morning and late evening, with a... were checked daily for visible signs of heat by examination of the vulvas for increased size and vascularity. After that time, they were checked twice daily with a vasectomized boar to determine the age of puberty. TABLE LC RATIONS USED IN THIS STUDZ...

Fowler, Stewart Hampton

2013-10-04

288

Suckling and weaning behavior in the collared peccary  

E-print Network

to allow mating with the female. If behaviors associated with mating (investigation of the vulva, biting the head/neck region by the male or female or mounting by the male or female) were not observed within 20 minutes after introduction, the female... to allow mating with the female. If behaviors associated with mating (investigation of the vulva, biting the head/neck region by the male or female or mounting by the male or female) were not observed within 20 minutes after introduction, the female...

Babbitt, Kimberly Jane

2012-06-07

289

Bacterial infections of the equine uterus  

E-print Network

on their second or third day of estrus. Methods of obtaining samples for the uterine cultures and cytologies followed very closely those described by Brook (1984). The mare was restrained in stocks, her tail wrapped and tied out of the way, and her vulva... on their second or third day of estrus. Methods of obtaining samples for the uterine cultures and cytologies followed very closely those described by Brook (1984). The mare was restrained in stocks, her tail wrapped and tied out of the way, and her vulva...

Jeffery, Arlene Celeste

2012-06-07

290

A professional internship with Southwest Embryos, Inc.  

E-print Network

-Shields, Reproductive Resources, Hebron, IL) over the tip. Sterile lubricant was applied to the tip of the sheath protector, and as the lips of the vulva were spread, the transfer gun was placed inside the vaginal cavity, A hemostat was attached to the flared lip...-Shields, Reproductive Resources, Hebron, IL) over the tip. Sterile lubricant was applied to the tip of the sheath protector, and as the lips of the vulva were spread, the transfer gun was placed inside the vaginal cavity, A hemostat was attached to the flared lip...

Marek, Delfin Edmund

2012-06-07

291

A study of the maturation process of the ovum of the sow during normal and induced ovulations  

E-print Network

days starting on day 16 of the cycle. The gilt was killed on day 19 of the cycle 72 hours after the first injection and showed psychological signs of heat on that day. She was willing to accept the boar, but the vulva was not swollen nor reddened... cycle she was treated with 35 units of gonado? tropin. On the twenty-first day of the estrus cycle, 55 hours after the injection, she was killed. The vulva was enlarged and reddened as in late proestrus, but no sign of heat was indicated when she...

Spalding, John Frederick

2013-10-04

292

Plasma estrogens and their relationship to uterine infection in the mare  

E-print Network

was demonstrated on 2 or more cultures. Each mare considered to be infected was treated with appropriate intra-uterine infusions and the vulva sutured in an effort to prevent continuing infection of the uterus. Treated mares were recultured on the following... was demonstrated on 2 or more cultures. Each mare considered to be infected was treated with appropriate intra-uterine infusions and the vulva sutured in an effort to prevent continuing infection of the uterus. Treated mares were recultured on the following...

Burns, Stuart James

2012-06-07

293

Squamous cell carcinoma arising in a case of vulvitis granulomatosa or vulval variant of Melkersson-Rosenthal syndrome.  

PubMed

A case of vulvitis granulomatosa or the vulval variant of Melkersson-Rosenthal syndrome (MRS) in a young adult patient with systemic lupus erythematosus is presented. She also had evidence of cervicovulvovaginal human papilloma virus (HPV) infection. Nine years later she developed a squamous cell carcinoma (SCC) of the vulva. HPV 6/11 was found by DNA in situ hybridization within a vulval condyloma as well as within the carcinoma. This case is unusual in that SCC associated with HPV 6/11 developed in her vulva affected by MRS rather than in the cervix, where SCC was more likely to occur considering this patient's age. PMID:1651278

Samaratunga, H; Strutton, G; Wright, R G; Hill, B

1991-06-01

294

Genetics of Egg-Laying William R. Schafer  

E-print Network

studied behaviors is egg-laying, the process by which hermaphrodites deposit developing embryos-laying neuromusculature. Shown is a ventral view of the hermaphrodite vulva and cells associated with egg-laying. Inferred. elegans hermaphrodites are self-fertile, pro- ducingfirstsperm,whicharestoredinthespe- matheca

Schafer, William R.

295

The CRAL/TRIO and GOLD domain protein TAP-1 regulates RAF-1 activation Kenneth G. Johnson, Kerry Kornfeld  

E-print Network

increased the oncogenic capacity of Ras transformed human cancer cell lines. These studies identify TAP-1 in this signaling pathway have important implica- tions for human health, since mutations leading of the hermaphrodite vulva, an epidermal structure for egg laying and sperm entry (Kornfeld, 1997; Greenwald, 1997

Kornfeld, S. Kerry

296

INTRODUCTION Many cells have mechanisms to control the position of the  

E-print Network

migration may lead to human disease. Mutations in LIS1 cause type I lissencephaly, in which neural migration into the cortex is disrupted (Dobyns and Truwit, 1995; Reiner et al., 1993). LIS1 is the human homolog and epithelial cells, some of which form the vulva, the egg laying and mating organ of hermaphrodites. 5039

Horvitz, H. Robert

297

20 CFR 10.404 - When and how is compensation for a schedule impairment paid?  

Code of Federal Regulations, 2013 CFR

...schedule members, organs and functions as defined in 5 U.S.C...that a schedule award for the skin may be paid for injuries on...and vulva/vagina 205 Skin 205 (c) Compensation...impairment of the same member or function or different parts of the...

2013-04-01

298

20 CFR 10.404 - When and how is compensation for a schedule impairment paid?  

Code of Federal Regulations, 2012 CFR

...schedule members, organs and functions as defined in 5 U.S.C...that a schedule award for the skin may be paid for injuries on...and vulva/vagina 205 Skin 205 (c) Compensation...impairment of the same member or function or different parts of the...

2012-04-01

299

Male-to-Female Sex Reassignment Surgery in Transsexuals  

Microsoft Academic Search

The technique of male-to-female sex reassignment surgery in a sample of 500 patients is described in detail and illustrated by 27 figures. Appropriate technique and care results in a naturally looking vulva and a functioning vagina. The complication rate is low, and most complications can be overcome by adequate correctional interventions.

Christiane Spehr

2007-01-01

300

Vulvar epithelioid hemangiosarcoma with solar elastosis in a mare.  

PubMed

A 15-year-old female gray Appaloosa horse was presented with history of a mass over the right dorsal commissure of vulva for the past 7 months. Based on histopathological examination, and positive staining with factor VIII-related antigen, vimentin, and Verhoeff-van Gieson stain, the vulvar mass was diagnosed as hemangiosarcoma with marked solar elastosis. PMID:21908370

Gumber, Sanjeev; Baia, Petrisor; Wakamatsu, Nobuko

2011-09-01

301

Soboliphyme occidentalis sp. nov. (Nematoda, Soboliphymidae) from the Iberian mole Talpa occidentalis (Insectivora, Talpidae) in Spain.  

PubMed

A new species of Soboliphyme from the endemic Iberian mole (Talpa occidentalis) is described. Soboliphyme occidentalis sp. nov. can be readily distinguished from all of its congeners primarily by the position of the vulva, which clearly shows a posterior oesophageal location, and the number of male caudal papillae. S. occidentalis sp. nov. is the only species that has four pairs of caudal papillae. S. abei, S. caucasica and S. jamesoni can be distinguished from S. occidentalis sp. nov. by not having a notched sucker, the anterior position of the vulva and two polar plugs in the eggs. S. jamesoni has an armate oral sucker and longer spicule; S. caucasica a longer spicule and shorter eggs, and S. abei has shorter eggs, which separate these species from S. occidentalis sp. nov. In the rest of the species with a notched oral sucker, S. baturini and S. hirudiniformis are differentiated from S. occidentalis sp. nov. by the anterior position of the vulva, two polar plugs in the egg and the spicule length in S. baturini and S. hirudiniformis and the size of eggs in S. baturini and S. hirudiniformis. S. ataahai, S. soricis and S. urotrichi have the vulva at the oesophago-intestinal junction, 9-10 male caudal papillae (S. ataahai and S. urotrichi), absence of male caudal papillae (S. soricis), armate oral sucker and long spicule in S. ataahai and one row of six circumoral spines in S. urotrichi. A key to the species of Soboliphyme is presented. PMID:15278444

Ribas, Alexis; Casanova, Joan Carles

2004-08-01

302

Clinical toxicology of clotrimazole when administered vaginally.  

PubMed

Clotrimazole, a tritylimidazole and a new antimicrobial agent, produced itching and irritation of the vulva and vaginal area in less than 1% of the population (N = 131) studied. No abdominal cramps, headache or lightheadedness, nausea, vomiting, and diarrhea were observed when 200 mg of clotrimazole was inserted deep in the vagina for several days. PMID:7009034

Wolfson, N; Riley, J; Samuels, B; Singh, J M

1981-01-01

303

Vulvar basal cell carcinoma.  

PubMed

Although the basal cell carcinoma (BCC) is the most common malignancy of skin, it is rarely seen in vulva and constitutes 2% to 4% of all vulvar cancers. The cause is unknown but, chronic vulvar irritation is the most important underlying factor. The patients over 60 years are affected more frequently than younger ones. PMID:23455815

Kara, Mustafa; Colgecen, E; Yildirim, Erdogan Nilsen

2012-01-01

304

Large vulvar lipoma in an adolescent: a case report.  

PubMed

Lipomas are the most common benign tumors of soft tissues. However, conventional lipomas have been reported only rarely as presenting in the vulva. We present a case of vulvar lipoma in a 17-yr-old woman, possibly caused by chronic intermittent irritation. PMID:18756071

Lee, Jung Hoon; Chung, Seung Moon

2008-08-01

305

similarly after anchor ablation [4]. More generally, no trend is  

E-print Network

for human influence on nematode distributions [12]. The third idea, and the one we favor? To address the canalization idea, the short lifespan and simple culture of Caenorhabditis suggests in nematode vulva development and evolution. Curr. Opin. Cell Biol. 13, 715­720. 3. Srinivasan, J., Pires

Gosselin, Frédéric

306

New and described species of nematodes from shorebirds (Charadriiformes) collected in spring in Iceland  

Microsoft Academic Search

The following were found in shorebirds collected during late April and early May shortly after their arrival in Iceland. Voguracuaria lankesteri n. g., n. sp. was found in the oesophagus of eight of 20 whimbrels Numenius p. phaeopus. The new genus resembles Syncuaria, but males have an area rugosa and small caudal alae, females are didelphic and the vulva is

P. L. Wong; R. C. Anderson

1993-01-01

307

Female pseudo-hermaphroditism with cloacal malformation and related anomalies in a dog  

PubMed Central

A 7-month-old intact female German shepherd dog was presented with recurrent urinary tract infections and incontinence, ambiguous external genitalia (enlarged vulva containing a penis), and an anovestibular fistula. Anatomical structures, histopathology, and karyotyping supported a diagnosis of female pseudo-hermaphrodite, hypothesized to be a result of in utero androgenization with consequential cloacal malformation. PMID:23543931

Sacks, Margot K.; Beraud, Romain

2012-01-01

308

Genetic control of vulval development in Caenorhabditis briggsae.  

PubMed

The nematode Caenorhabditis briggsae is an excellent model organism for the comparative analysis of gene function and developmental mechanisms. To study the evolutionary conservation and divergence of genetic pathways mediating vulva formation, we screened for mutations in C. briggsae that cause the egg-laying defective (Egl) phenotype. Here, we report the characterization of 13 genes, including three that are orthologs of Caenorhabditis elegans unc-84 (SUN domain), lin-39 (Dfd/Scr-related homeobox), and lin-11 (LIM homeobox). Based on the morphology and cell fate changes, the mutants were placed into four different categories. Class 1 animals have normal-looking vulva and vulva-uterine connections, indicating defects in other components of the egg-laying system. Class 2 animals frequently lack some or all of the vulval precursor cells (VPCs) due to defects in the migration of P-cell nuclei into the ventral hypodermal region. Class 3 animals show inappropriate fusion of VPCs to the hypodermal syncytium, leading to a reduced number of vulval progeny. Finally, class 4 animals exhibit abnormal vulval invagination and morphology. Interestingly, we did not find mutations that affect VPC induction and fates. Our work is the first study involving the characterization of genes in C. briggsae vulva formation, and it offers a basis for future investigations of these genes in C. elegans. PMID:23275885

Sharanya, Devika; Thillainathan, Bavithra; Marri, Sujatha; Bojanala, Nagagireesh; Taylor, Jon; Flibotte, Stephane; Moerman, Donald G; Waterston, Robert H; Gupta, Bhagwati P

2012-12-01

309

[Monosymptomatic Melkersson-Rosenthal syndrome with subsequent vulvitis and perivulvitis granulomatosa].  

PubMed

We report on an 40-year-old woman with granulomatous facial swelling followed by vulvitis and perivulvitis granulomatosa. The characteristic histopathology with epitheloid cell granulomas was seen in samples from both the face and the vulva. By immunohistochemistry the lesions were characterized as consisting mainly of histiocytic and CD-30-positive T cells. The possible aetiology is discussed briefly. PMID:1334950

Knopf, B; Schaarschmidt, H; Wollina, U

1992-11-01

310

HUMAN GENE THERAPY 18:547561 (June 2007) Mary Ann Liebert, Inc.  

E-print Network

. #12;diseases including cancer of the vulva, oral cancer, and skin cancer (Beckmann et al., 1988.042 A Cancer Cell-Specific Inducer of Apoptosis KATIE L. GREEN,1 CRAIG BROWN,1 GERALDINE E. ROEDER,1 THOMAS D cancers, strongly suggesting that these viruses are necessary to initiate this disease. The HPV E2 protein

Gaston, Kevin

311

Familial partial lipodystrophy: two types of an X linked dominant syndrome, lethal in the hemizygous state  

Microsoft Academic Search

Familial lipodystrophy (referred to in publications as the Köbberling-Dunnigan syndrome) comprises at least two clinical phenotypes which are consistent within each pedigree. In type 1 familial lipodystrophy, loss of subcutaneous fat is confined to the limbs, sparing the face and trunk. In type 2 familial lipodystrophy, the trunk is also affected with the exception of the vulva, giving an appearance

J Köbberling; M G Dunnigan

1986-01-01

312

A polycystic kidney-disease gene homologue required for male mating behaviour in C. elegans  

Microsoft Academic Search

The stereotyped mating behaviour of the Caenorhabditis elegans male is made up of several substeps: response, backing, turning, vulva location, spicule insertion and sperm transfer. The complexity of this behaviour is reflected in the sexually dimorphic anatomy and nervous system. Behavioural functions have been assigned to most of the male-specific sensory neurons by means of cell ablations; for example, the

Maureen M. Barr; Paul W. Sternberg

1999-01-01

313

Syphilis Symptoms  

MedlinePLUS

... primary syphilis is often a small, round, firm ulcer (sore) called a chancre ("shanker") at the place where the bacteria entered your body. This place is usually the penis, vulva, or vagina, but chancres also can develop on the cervix, tongue, lips, or other parts of the body. Usually ...

314

Syndrome in question*  

PubMed Central

Vulvovaginal-gingival syndrome is characterized by erosions and desquamation of the vulva, vagina, and gingiva. We reported a case of a 32-year-old woman presenting with an 8-year history of damage to the vulval and perianal anatomy and limitation of mouth opening. The patient's symptoms were relieved after treatment with topical tacrolimus cream. PMID:25184936

Wu, Yinhua; Qiao, Jianjun; Fang, Hong

2014-01-01

315

Evaluation of the Role of Vibrational Spectroscopy in the Assessment of Vulval Disease  

ClinicalTrials.gov

Normal Vulval Skin; Lichen Sclerosus; High Grade Dysplasia - Usual Type ('VIN 2-3'); High Grade Dysplasia - Differentiated Type ('VIN 2-3'); Squamous Cell Carcinoma; Epithelial Hyperplasia Without Atypia; Atypia Not Otherwise Specified/ Low Grade Dysplasia ('VIN 1'); Pagets Disease of the Vulva

2014-08-21

316

Chapter 1: HPV in the etiology of human cancer  

Microsoft Academic Search

The causal role of human papillomavirus (HPV) in all cancers of the uterine cervix has been firmly established biologically and epidemiologically. Most cancers of the vagina and anus are likewise caused by HPV, as are a fraction of cancers of the vulva, penis, and oropharynx. HPV-16 and -18 account for about 70% of cancers of the cervix, vagina, and anus

Nubia Muñoz; Xavier Castellsagué; Amy Berrington de González; Lutz Gissmann

2006-01-01

317

Rare variants of malignant melanoma  

Microsoft Academic Search

The personal experience with 5 rare types of malignant melanoma is reviewed to point out some of the practical problems in the diagnosis and management of these tumors. The rare forms discussed are conjunctival, nasal, oral, vulvar, and penile melanomas. All pigmented lesions in the oral cavity, but not the penis or vulva, should be prophylactically excised as lesions in

G. W. Milton; H. M. Shaw

1992-01-01

318

Neonatal levels of plasma thyroxine in male and female calves fed a colostrum or immunoglobulin diet or fasted for  

E-print Network

immunoglobulins and the rest mostly bovine serum albumi slightly accelerated by mild traction on the forelimbs of the calf after they appeared outside the vulva of immunoglobulins (29 g/kg of body weight/meal) extracted from bovine colostrum by a process described elsewhere

Boyer, Edmond

319

Vulvar lichen sclerosus and squamous cell carcinoma: A cohort, case control, and investigational study with historical perspective; implications for chronic inflammation and sclerosis in the development of neoplasia  

Microsoft Academic Search

The histological changes of lichen sclerosus (LS) are frequently found in association with vulvar squamous cell carcinoma (SCC). The importance of chronic inflammation and scarring in oncogenesis is well recognized. Thirty-two patients with symptomatic vulvar LS and 60 with vulvar SCC were studied. Paraffin sections of vulvar LS, and three controls groups (acute scars, normal vulva, and vulvar lichen simplex

J. Andrew Carlson; Robert Ambros; John Malfetano; Jeffery Ross; Richard Grabowski; Philina Lamb; Helen Figge; Martin C Mihm

1998-01-01

320

Eosinophilic Pleuritis due to Sparganum: A Case Report  

PubMed Central

Sparganosis is a rare parasitic disease caused by migrating plerocercoid tapeworm larva of the genus Spirometra. Infection in humans is mainly caused by the ingestion of raw or inadequately cooked flesh of infected frogs, snakes, and chickens. Here, we report a rare case of a 45-year-old man who was admitted to our hospital with left lower chest pain. The chest radiograph and computed tomography (CT) scan revealed localized pleural effusion in the left lower lobe; further, peripheral blood eosinophilia and eosinophilic pleural effusion were present. Percutaneous catheter drainage was performed, which revealed long worm-shaped material that was identified as a sparganum by DNA sequencing. The patient showed clinical improvement after drainage of the sparganum. This study demonstrates the importance of considering parasitic diseases in the differential diagnosis of eosinophilic pleural effusion.

Oh, Youngmin; Kim, Jeong-Tae; Kim, Mi-Kyeong; Chang, You-Jin; Eom, Keeseon; Park, Jung-Gi; Lee, Ki-Man; Choe, Kang-Hyeon

2014-01-01

321

Eosinophilic Pleuritis due to Sparganum: A Case Report.  

PubMed

Sparganosis is a rare parasitic disease caused by migrating plerocercoid tapeworm larva of the genus Spirometra. Infection in humans is mainly caused by the ingestion of raw or inadequately cooked flesh of infected frogs, snakes, and chickens. Here, we report a rare case of a 45-year-old man who was admitted to our hospital with left lower chest pain. The chest radiograph and computed tomography (CT) scan revealed localized pleural effusion in the left lower lobe; further, peripheral blood eosinophilia and eosinophilic pleural effusion were present. Percutaneous catheter drainage was performed, which revealed long worm-shaped material that was identified as a sparganum by DNA sequencing. The patient showed clinical improvement after drainage of the sparganum. This study demonstrates the importance of considering parasitic diseases in the differential diagnosis of eosinophilic pleural effusion. PMID:25352705

Oh, Youngmin; Kim, Jeong-Tae; Kim, Mi-Kyeong; Chang, You-Jin; Eom, Keeseon; Park, Jung-Gi; Lee, Ki-Man; Choe, Kang-Hyeon; An, Jin-Young

2014-10-01

322

Food-borne parasitic zoonoses in the People's Republic of China.  

PubMed

The People's Republic of China has a large number of animal parasites transmitted through the ingestion of food products. Approximately 20 species of parasites in animals and man are reported from most of the provinces and autonomous regions of the country. The major food-borne parasitic zoonoses are reported from pigs, cattle, fish, crabs and crayfish, snails, frogs, snakes, and aquatic plants. The most important diseases are toxoplasmosis, taeniasis, cysticercosis, sparganosis, clonorchiasis, fascioliasis, fasciolopsiasis, paragonomiasis, echinostomiasis, trichinosis, gnathostomiasis, and angiostrongyliasis. There is concern that some of these parasitoses may develop into more serious problems because of the increase in free-market commerce and the lack of adequate inspection of food products. Furthermore, many cultures in China enjoy eating raw or inadequately cooked food products. Control programs have been initiated utilizing newer drugs, but there must also be educational programs, as well as an improvement in sanitation. PMID:1822913

Li, X

1991-12-01

323

Identification of early diagnostic antigens from Spirometra erinaceieuropaei sparganum soluble proteins using immunoproteomics.  

PubMed

In order to identify early specific diagnostic antigens of Spirometra erinaceieuropaei (syn. S. erinacei or S. mansoni) sparganum, soluble proteins were analyzed by two-dimensional electrophoresis (2-DE) and western blotting probed with immune sera from infected mice at 14 days post-infection. From a total of approximately 462 proteins spots mainly distributed in pI range of 5-6.6 and with molecular mass of 25-48 kDa, 6 immuno-reactive protein spots with molecular mass of 31.8-38.3 kDa were characterized by MALDI-TOF/TOF-MS. Three proteins were identified as S. erinaceieuropaei cysteine protease, Toxoplasma gondii hypothetical protein and Pecten spp actin, while the remaining were unidentified. The cysteine protease from S. erinaceieuropaei soluble proteins recognized by early infection sera might be developed as diagnostic reagent for early detection of sparganosis. PMID:24974641

Hu, Dan Dan; Cui, Jing; Xiao, Di; Wang, Li; Liu, Li Na; Liu, Ruo Dan; Zhang, Jian Zhong; Wang, Zhong Quan

2014-05-01

324

Migraine misdiagnosis as a sinusitis, a delay that can last for many years  

PubMed Central

Background Sinusitis is the most frequent misdiagnosis given to patients with migraine. Therefore we decided to estimate the frequency of misdiagnosis of sinusitis among migraine patients. Methods The study included migraine patients with a past history of sinusitis. All included cases fulfilled the International Classification of Headache Disorders, 3rd edition (ICHD-III- beta) criteria. We excluded patients with evidence of sinusitis within the past 6 months of evaluation. Demographic data, headache history, medical consultation, and medication intake for headache and effectiveness of therapy before and after diagnosis were collected. Results A total of 130 migraine patients were recruited. Of these patients 106 (81.5%) were misdiagnosed as sinusitis. The mean time delay of migraine diagnosis was (7.75?±?6.29, range 1 to 38 years). Chronic migraine was significantly higher (p?misdiagnosed patients than in patients with proper diagnosis. Medication overuse headache (MOH) was reported only in patients misdiagnosed as sinusitis. The misdiagnosed patients were treated either medically 87.7%, or surgically12.3% without relieve of their symptoms in 84.9% and 76.9% respectively. However, migraine headache improved in 68.9% after proper diagnosis and treatment. Conclusions Many migraine patients were misdiagnosed as sinusitis. Strict adherence to the diagnostic criteria will prevent the delay in migraine diagnosis and help to prevent chronification of the headache and possible MOH. PMID:24330723

2013-01-01

325

Two new species of Rhabdias (Nematoda: Rhabditida: Rhabdiasidae) in anuran hosts from Dehradun (Uttarakhand), India.  

PubMed

Rhabdias himalayanus n. sp. from the lungs of Duttaphrynus himalayanus and Rhabdias dehradunensis n. sp. from the lungs of Nanorana minica from Dehradun, India are described and figured. Of the 3 previously described Indian species, Rhabdias himalayanus n. sp. is most similar to Rhabdias shortii in having a cylindrical corpus, inflated cuticle, and conical tail; it differs from R. shortii in having greater body measurements, longer esophagus, larger eggs, and a different pattern of cuticle inflation at the vulva and tail region. Rhabdias dehradunensis n. sp. is most similar to Rhabdias bulbicauda in that both possess a swollen posterior end; it differs from R. bulbicauda by having a subterminal anus, a prominent tail, and a postequatorial vulva. PMID:23020804

Rizvi, Anjum N; Bursey, Charles R; Bhutia, Pasang T

2013-04-01

326

Magnetic resonance imaging of vulvar dermatofibrosarcoma protuberans - report of a case  

PubMed Central

Background Dermatofibrosarcoma protuberans (DFSP) of the vulva is a rare low-grade soft tissue sarcoma. Magnetic resonance imaging (MRI) findings of vulvar DFSP were essentially unreported in the literature. Case report We report a DFSP of vulva with its clinical, histological and MRI features. As far we know this is the first case of histologically confirmed vulvar DFSP presenting with MR images. The diagnosis of DFSP is usually made by histopathologic and clinical findings. Conclusions MRI is useful both for the diagnosis of DFSP and following up the patients since it has high soft tissue resolution and no risk of radiation exposure. With MRI the relation to the adjacent anatomical structures, extension and depth of the tumour and possible lymph node involvement can also be demonstrated. PMID:24133389

Ozmen, Evrim; Guney, Guven; Algin, Oktay

2013-01-01

327

Diagnostico de Prenez en Ganado Vacuno.  

E-print Network

Becerros logrados (por 100 vacas) 550' 500 450 400 350 1 90 19.2 21.1 23.5 26.4 30.2 330 300 270 240 21 0 60 28.8 31.7 35.2 39.6 45.2 'Los nlimeros de arriba indican libras de becerro producido por vaca. CARUNCULAS \\ VULVA Figura 2. Anatornia del... Becerros logrados (por 100 vacas) 550' 500 450 400 350 1 90 19.2 21.1 23.5 26.4 30.2 330 300 270 240 21 0 60 28.8 31.7 35.2 39.6 45.2 'Los nlimeros de arriba indican libras de becerro producido por vaca. CARUNCULAS \\ VULVA Figura 2. Anatornia del...

Sorensen, A. M. Jr.; Beverly, J. R.; Arias, A. A.

1975-01-01

328

Urogenital atrophy.  

PubMed

The major cause of urogenital atrophy in menopausal women is estrogen loss. The symptoms are usually progressive in nature and deteriorate with time from the menopausal transition. The most prevalent urogenital symptoms are vaginal dryness, vaginal irritation and itching. The classical changes in an atrophic vulva include loss of labial and vulvar fullness, with narrowing of the introitus and inflamed mucosal surfaces. Dyspareunia and vaginal bleeding from fragile atrophic skin are common problems. Other urogenital complaints include frequency, nocturia, urgency, incontinence and urinary tract infections. Atrophic changes of the vulva, vagina and lower urinary tract can have a large impact on the quality of life of the menopausal woman. However, hormonal and non-hormonal treatments can provide patients with the solution to regain previous level of function. Therefore, clinicians should sensitively question and examine menopausal women, in order to correctly identify the pattern of changes in urogenital atrophy and manage them appropriately. PMID:19387880

Calleja-Agius, J; Brincat, M P

2009-08-01

329

[Urinary retention caused by vulvar carcinoma].  

PubMed

Epidermoid carcinoma is the most frequent neoplasia of the vulva. It usually appears in aged post-menopausal women (51-70 years). The signs and symptoms are unremarkable: vulvar bulk or protuberance, pruritus, painful ulcer, flow, vulvar irritation, dysuria or haemorrhage, all of which motivate that this condition may be ignored, overlooked, or be the cause of self-treatment. At other times a dangerous shyness causes considerable delays by postponing the visit to the specialist. Many patients refuse to go to see a physician. The existence of urinary signs and symptoms in a patient with vulvar neoplasia are indicative of urethral invasion and the advanced stage of the condition. A case is presented here of an advanced vulva carcinoma in an 82 year-old woman who come with urinary retention by urethral infiltration and perineal destruction. We review the most relevant aspects of vulvar carcinomas associated with obstructive uropathy. PMID:7717162

Romero Pérez, P

1995-01-01

330

Morphological Variation in Xiphinema spp. from New York Orchards.  

PubMed

Xiphinema specimens were collected from orchards in southeastern, northeastern, and western New York. Total length, distance of vulva from anterior end, spear length (odontostyle plus odontophore), body diameter at vulva, tail length, anal body diameter, and length and diameter of hyaline tail tip were measured on fixed, glycerol-infiltrated adult females. Most specimens were identified as X. americanum or X. rivesi, but one western New York population was identified as X. californicum (a new record for New York). Multivariate analyses indicated that, with one exception, western New York populations of both X. americanum and X. rivesi were smaller and slimmer than their eastern counterparts. Regional differences were generally larger than differences attributed to host species. PMID:19290184

Georgi, L L

1988-01-01

331

Gynecological Cancers  

Microsoft Academic Search

\\u000a Gynecological cancers include cancers of the vulva, the vagina, the cervix, the uterus, and the ovaries. All these cancers\\u000a can affect sexual functioning in many different ways, from the psychological impact of the diagnosis to the psycho­physiological\\u000a impact of the disease itself, as well as the therapeutic interventions, including surgery, chemotherapy, and radiotherapy.\\u000a Sometimes sexual functioning is already affected prior

J. Bitzer; J. Alder

332

Pelvic Radiation in Women  

Microsoft Academic Search

\\u000a Pelvic radiation represents a major therapeutic strategy, either as adjuvant or primary treatment in the management of cancer\\u000a in women. This mainly concerns women with gynaecological malignancies: endometrial, cervical, vaginal, and vulva cancer; intestinal\\u000a malignancies: rectal and anal cancer, and bladder cancer. Further, long-term breast cancer survivors may experience similar\\u000a adverse effects after ovarian ablation accomplished by pelvic radiation. Finally,

Pernille T. Jensen

333

[Expression of VEGF, KDR, p53, E6 HPV16 and HPV18 in vulvar and cervix cancer].  

PubMed

The aim of the study was a comparison of expression of angiogenesis genes: vascular endothelial growth factor (VEGF), KDR, suppressor gene p53, E6-HPV16 and HPV18, in tissue samples of normal, dystrophic, lymph nodes and malignant cancers of vulva and uterine cervix. The results demonstrate that molecular diagnostics of cancers using gene expression profiling indicates the definitive difference in expression profiles of aforementioned genes in tissues of the same malignancy. PMID:10983377

Michalski, B; Mazurek, U; Olejek, A; Ku?mierz, D; Poreba, R; Witek, A; Wilczok, T

2000-01-01

334

Patients with usual vulvar intraepithelial neoplasia-related vulvar cancer have an increased risk of cervical abnormalities  

Microsoft Academic Search

Background:Vulvar squamous cell carcinoma (SCC) originates the following two pathways, related to differentiated (d) vulvar intraepithelial neoplasia (VIN) or to human papillomavirus (HPV)-related usual (u) VIN. Multicentric HPV infections (cervix, vagina and vulva) are common. We hypothesise that patients with a uVIN-related vulvar SCC more often have cervical high-grade squamous intraepithelial lesions (HSILs) compared with women with dVIN-related vulvar SCC.Methods:All

R. P. de Bie; H. P. van de Nieuwenhof; R. L. M. Bekkers; W. J. G. Melchers; A. G. Siebers; J. Bulten; L. F. A. G. Massuger; J. A. de Hullu; RP de Bie

2009-01-01

335

External Anogenital Premalignant and Malignant Disease  

Microsoft Academic Search

The external anogenital area comprises the anus, perianal skin, and the adjacent external genitalia including the vulva and\\u000a vaginal introitus in the female, and the penis and scrotum in the male. Immunosuppressed organ transplant recipients (OTR)\\u000a are prone to viral infections, and have an increased incidence of human papillomavirus (HPV) associated premalignant and malignant\\u000a neoplasms, which specifically target the anogenital

Karen L. Gibbon; Arucha L. Ekeowa-Anderson; Irene M. Leigh

336

Treatment of recurrent vulvar Paget disease with imiquimod cream: a case report and review of the literature  

Microsoft Academic Search

Introduction  Extra-mammary Paget disease is one of the rare neoplastic conditions of the skin. The most common site of involvement is the\\u000a vulva and presents itself with erythematous plaques. Surgery is the most important treatment option. In the recent years,\\u000a there are publications of the topical use of imiquimod cream in extra-mammary cutaneous Paget disease. We report the case\\u000a of a

Esra Tonguc; Tayfun Güngor; Turgut Var; Mustafa Ozat; Izzet Sahin; Levent Sirvan

2011-01-01

337

Vulvar problems in elderly women. Don't assume that menopause is the culprit.  

PubMed

Like many other parts of the body, the vulva is affected by cessation of estrogen after menopause. Vulvar pruritus and irritation are common findings with normal aging, but they may also be signs of infection, inflammation, or other skin conditions. Misdiagnosis results in incorrect treatment, a dissatisfied patient and, often, referral to a gynecology clinic. In this article, two instructors in the field describe acute and chronic vulvar disorders and summarize how to identify and treat them. PMID:9300022

Barhan, S; Ezenagu, L

1997-09-01

338

Vulvar carcinoma  

Microsoft Academic Search

Opinion statement  Carcinoma of the vulva is an uncommon gynecologic malignancy primarily affecting postmenopausal women. The lesion is most\\u000a commonly associated with HPV DNA, although, for many, a defined preinvasive to invasive connection is not readily apparent.\\u000a Most patients experience symptoms of pruritus, irritation, and even pain for weeks or months before the diagnostic biopsy\\u000a is performed. Patient embarrassment and unfamiliarity

Robert L. Coleman; Joseph T. Santoso

2000-01-01

339

Vaginal Discharge (2)  

Microsoft Academic Search

\\u000a Mary is a 26-year-old woman who attends a Sexual Health clinic. For the preceding 2 weeks she has noticed a profuse, yellow\\u000a vaginal discharge that has a rather musty smell. She also has noted mild irritation on the vulva and she has had some discomfort\\u000a on passing urine. She is otherwise symptomless. Her menstrual periods are regular; the most recent

Alexander McMillan

340

Ovarian carcinoma producing parathyroid hormone-related protein causing hypercalcemia and metastatic calcification detected on 18F-FDG PET-CT  

PubMed Central

Hypercalcemia is associated with gynecologic malignant diseases, and cases involving various organs such as the uterus, ovaries, vulva, and vagina. This may be due to elevated levels of parathyroid hormone-related peptide (PTHrP). We describe here two cases of ovarian carcinoma simultaneously producing PTHrP that caused hypercalcemia and metastatic calcification detected on 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography-computed tomography (PET-CT). PMID:24379537

Agarwal, Krishan Kant; Karunanithi, Sellam; Jain, Sachin; Kumar, Rakesh

2013-01-01

341

LET23 Receptor Localization by the Cell Junction Protein LIN7 during C. elegans Vulval Induction  

Microsoft Academic Search

In C. elegans, the anchor cell signal induces Pn.p cells to form the vulva by activating a conserved receptor tyrosine kinase pathway. lin-2 and lin-7 mutants exhibit a vulvaless phenotype similar to the phenotype observed when this signaling pathway is defective. We have found that LIN-7 is a cell junction–associated protein that binds to the LET-23 receptor tyrosine kinase. LET-23

Jeffrey S Simske; Susan M Kaech; Stacey A Harp; Stuart K Kim

1996-01-01

342

Vulvitis granulomatosa and anoperineitis granulomatosa.  

PubMed

We present the case of a 77-year-old female with a rare genital and anoperineal granulomatous cutaneous manifestation resembling cheilitis granulomatosa Miescher. The typical histological findings of epithelioid cell granulomas were localized in the vulva and anoperineal region; the latter manifestation has not yet been described. Based on our personal observations and a review of the literature, the clinical and histological features of vulvitis granulomatosa are described. PMID:2050234

Hackel, H; Hartmann, A A; Burg, G

1991-01-01

343

Eosinophilia in squamous cell carcinoma of the oral cavity, external genitalia and anus--clinical correlations.  

PubMed

The incidence and pattern of tumour-associated eosinophilia is described in squamous cell carcinomas of the oral cavity, vulva, penis, scrotum and anus. Massive tissue eosinophilia appears to be related to the histological differentiation of the tumours in which it occurs, and in the cases in this series was associated with a favourable prognosis. Circulating eosinophilia occurred in patients with metastatic disease and a poor prognosis. PMID:6479905

Lowe, D; Fletcher, C D

1984-07-01

344

Rare and Uncommon Gynaecological Cancers: A Clinical Guide  

Microsoft Academic Search

\\u000a The female genital tract, comprising the vulva, vagina, uterine cervix and corpus, fallopian tubes and ovaries, as well as\\u000a the pelvic peritoneum as part of the secondary Mullerian system, is characterised by the occurrence of a greater range of\\u000a tumour types than any other organ system in the body. This is especially so in the ovary where numerous diverse tumours,

W. Glenn McCluggage; David Millan

345

Female Genital Surgery  

Microsoft Academic Search

\\u000a Our society attributes great importance to appearance and body image. In the recent past, cosmetic vulvar plastic surgery\\u000a has been widely introduced in the western world. Modification of the cultural environment and increasing vulvar “visibility”\\u000a have generated the erroneous identification of an ideally “normal” appearing vulva. The links between partner’s relationship,\\u000a sexuality, and body image have become more strict, and

Francesca De Lorenzi; Elena Mascolo; Francesca Albani; Mario Sideri

346

Icosiella turgeocauda n. sp. (Nematoda: Onchocercidae) and Seuratascaris numidica (Nematoda: Ascarididae), parasites of the frog, Rana cancrivora (Anura: Ranidae), from Luzon, Republic of the Philippines.  

PubMed

Icosiella turgeocauda n. sp. from the intestinal mesenteries of Rana cancrivora collected at Luzon, Republic of the Philippines, is described and illustrated. Icosiella turgeocauda n. sp. represents the ninth species to be assigned to the genus and is easily differentiated from all the previously described species by the position of the vulva and the presence of bilateral umbos on the caudal end of the male. Seuratascaris numidica also was found. The Philippines represents a new location record for S. numidica. PMID:12760651

Bursey, Charles R; Telford, Sam R; Goldberg, Stephen R

2003-04-01

347

The vulvar epithelium differs from the skin: implications for cutaneous testing to address topical vulvar exposures.  

PubMed

Vulvar tissue is more permeable than exposed skin due to differences in structure, occlusion, hydration and susceptibility to friction. The safety assessment of products that contact the vulva should account for this potentially heightened permeability. Standard clinical patch tests may not sufficiently mimic vulvar exposures. Because testing on the vulva is not routinely feasible, we are investigating new and modified cutaneous test methods to increase the degree of conservatism of the safety assessment. To this end, we have 1) developed a method to assess chemical and frictional effects by means of repeated application to the popliteal fossa (the behind-the-knee test); 2) modified the quantitative risk assessment for the induction of allergic contact dermatitis; and 3) proposed a modified human repeat insult patch test for assessing materials intended for vulvar contact. Modification of the traditional 4-day, irritation patch test by using wet samples or compromized skin sites failed to enhance test sensitivity. Future studies will evaluate testing in subjects with heightened susceptibility to chemical and sensory irritation, in order to increase test sensitivity to chemical irritants. These approaches can be employed to augment the margin of safety when cutaneous test methods are applied to agents that contact the vulva. PMID:15500670

Farage, Miranda; Maibach, Howard I

2004-10-01

348

Influence of menstruation on the microbiota of healthy women's labia minora as analyzed using a 16S rRNA gene-based clone library method.  

PubMed

The aim of this study was to determine the influence of menstruation on the bacterial population of healthy Japanese women's vulvas, especially the labia minora. Labia minora swabs were obtained from 10 premenopausal, nonpregnant Japanese women at premenstruation and on day 2 of menstruation. Vaginal swabs were also obtained from 3 out of the 10 women. No significant difference was found in the average bacterial cell count between the menstruation and premenstruation samples. Molecular analysis using a 16S rRNA gene-based clone library method detected 22 genera from the labia minora swabs (total 20), with the genus Lactobacillus being predominant at both premenstruation and during menstruation in 7 out of the 10 women. Of the other 3 women, 2 showed various kinds of bacterial species, including oral and fecal bacteria, with Atopobium vaginae and Gardnerella vaginalis predominating in the remaining woman's vulva in both conditions. In total, 6 out of 10 cases (60%) showed significantly different microbiota of the labia minora between the two conditions. These results imply that menstruation may promote a distortion of the bacterial flora around the vulva, although it causes no significant increase of the bacterial count. PMID:21266747

Shiraishi, Tsukasa; Fukuda, Kazumasa; Morotomi, Nobuo; Imamura, Yuri; Mishima, Junko; Imai, Shigeo; Miyazawa, Kiyoshi; Taniguchi, Hatsumi

2011-01-01

349

Comparative vaginal cytology of the estrous cycle of black-footed ferrets (Mustela nigripes), Siberian polecats (M. eversmanni), and domestic ferrets (M. putorius furo).  

PubMed

Vaginal cytology and vulva size were used to characterize the reproductive cycle of female black-footed ferrets (Mustela nigripes), Siberian polecats (M. eversmanni), and domestic ferrets (M. putorius furo). Emphasis was on black-footed ferrets because of the need to breed these critically endangered animals and on Siberian polecats because of the close taxonomic relationship to black-footed ferrets. Vaginal cytology of the 3 species of ferret is similar. Proestrus was characterized by an increasing percentage of superficial epithelial cells and enlargement of the vulva. During estrus, superficial cells were usually greater than or equal to 90% of epithelial cells in the vaginal lavage and after several days were fully keratinized. Neutrophils were more common during all stages of the estrous cycle in domestic ferrets than they were in the other species. Following copulation, percentage of superficial calls in the vagina declined and vulva swelling subsided. Large cells, probably of uterine symplasma origin, were observed in vaginal lavages following whelping or pseudopregnancy. Vaginal cytology is extremely useful in the reproductive management of black-footed ferrets and Siberian polecats. Knowledge of normal vaginal cytology could be applied to the diagnosis of female reproductive abnormalities in all 3 species. PMID:1554767

Williams, E S; Thorne, E T; Kwiatkowski, D R; Lutz, K; Anderson, S L

1992-01-01

350

Pitfalls in the Diagnosis of Immune Thrombocytopenic Purpura in Children: 4 Case Reports  

Microsoft Academic Search

Acute idiopathic thrombocytopenic purpura is the most common cause of thrombocytopenia in childhood, and diagnosis of idiopathic thrombocytopenic purpura is made clinically based on the exclusion of other causes of thrombocytopenia. Patients with diverse causes of thrombocytopenia are sometimes erroneously diagnosed as having idiopathic thrombocytopenic purpura. However, for the prevention of misdiagnoses, careful inspection of peripheral blood smear is of

Betül Biner; Ömer Devecio?lu; Muzaffer Demir

2007-01-01

351

Solitary fibrous tumor (SFT) of the pelvis  

Microsoft Academic Search

Solitary fibrous tumors (SFTs) are well recognized in the pleura, but their occurrence at other sites has only become appreciated in recent years, as a consequence of which extrapleural examples often go unrecognized and misdiagnosed. Because of their rarity, overall experience concerning this tumor has not been significant and reports detailing radiological findings are few. We herein report an unusual

Shiu Yan J. Wat; Monalisa Sur; Kavita Dhamanaskar

2008-01-01

352

Identifying Hearing Loss in Young Children: Technology Replaces the Bell  

ERIC Educational Resources Information Center

Hearing loss can too easily be misdiagnosed or overlooked by providers serving young children. Parents and professionals may observe a language delay--an "invisible" condition--while failing to identify the underlying cause. Otoacoustic emissions (OAE) hearing screening technology, used extensively with newborns, is becoming an essential tool,…

Eiserman, William; Shisler, Lenore

2010-01-01

353

VISUAL THERAPY: HELPING LEARNERS WHO HAVE TROUBLE LEARNING  

Microsoft Academic Search

Children who struggle to learn to read and write suffer embarrassment and pain; their parents are often frustrated, confused, and angry with their children, as well as their children's teachers. If a learning problem is noticed, it can be often misdiagnosed and\\/or the symptoms may be treated instead of the cause - when no improvement is then observed after remediation,

Robin Evers

354

Early Identification of Learning Disabilities: A Comparison of Two Methods.  

ERIC Educational Resources Information Center

An unadjusted low-achievement criterion was compared with a regression-discrepancy criterion for identifying learning disabled children. The use of an unadjusted achievement raw score criterion resulted in misdiagnosing many children as learning disabled, while failing to identify many others. Different sets of predictor variables were associated…

Horn, Wade F.; O'Donnel, James P.

1984-01-01

355

Computer vision and digital imaging technology in melanoma detection  

Microsoft Academic Search

With today's treatment options, melanoma cure rates can be improved only if the diagnosis is made early enough to allow for curative surgery. Since clinical signs of malignancy in a pigmented lesion are often ambiguous and even dermatology experts may misdiagnose melanoma, diagnostic tools and procedures have been developed to assist the clinician in the diagnostic workup. Epiluminescence microscopy or

Holger Voigt; Richarda Classen

2002-01-01

356

The Increase of Bipolar Disorder in Children and Adolescents  

Microsoft Academic Search

This cluster study investigates the different possibilities that may have caused an increase in the diagnosis of Bipolar Disorder in children and adolescents, including comparison to diagnosis in other countries. The same criteria for diagnosis of Bipolar Disorder for adults are used for children and adolescents, which may be misdiagnosed due to other disorders having the same characteristics, such as

Kristen Wroblewski

2008-01-01

357

Diagnosis or Misdiagnosis  

ERIC Educational Resources Information Center

How frequently are gifted children misdiagnosed? Frankly, there are no research data, though the authors know it occurs, and perhaps frequently. How do individuals draw this conclusion? Because the authors have tested children whose parents have come to them for a second (or third) opinion, and in their clinical experience it appears that…

Webb, James T.; Goerss, Jean; Amend, Edward R.; Webb, Nadia E.; Beljan, Paul; Olenchak, F. Richard

2006-01-01

358

Decreased level of psychobiological factor novelty seeking and lower intelligence in men  

E-print Network

and toxoplasmosis? Jaroslav Flegr a, *, Marek Preiss b , Jiri´ Klose c , Jan Havli´cek d , Martina Vita, characterized by rapid reproduction of tachyzoites in cells of different tissues, is a relatively mild disease. Usually, it is unrecorded or is misdiagnosed as a common viral or bacterial disease. Within weeks

Flegr, Jaroslav

359

Development of an Expert System for Aiding Migraine Diagnosis  

E-print Network

migraines from other types of headaches. The application utilises a data collection form, the C Language Technology in Healthcare 2004; 2(5): 355­364 INTRODUCTION Headaches in a variety of forms are one of the most and maintaining patient function2 . How- ever, migraines are frequently underdiagnosed or misdiagnosed as tension

Kopec, Danny

360

Familial occurrence of isolated non-compaction cardiomyopathy  

Microsoft Academic Search

Background and aims: Isolated left ventricular non-compaction cardiomyopathy (LVNC) may have an autosomal dominant or X-linked recessive inheritance. We focus on the familial occurrence of LVNC after misdiagnosing this disorder in symptomatic patients in two families. After identification of the index patient we studied the families more intensively in order to unmask affected family members. Methods and results: LVNC was

Anouk Lorsheyd; Maarten-Jan M. Cramer; Birgitta K. Velthuis; Evert-Jan P. Vonken; Jasper van der Smagt; Peter van Tintelen; Richard N. W. Hauer

361

Performance of Working Class African-American Children on Three Tests of Articulation.  

ERIC Educational Resources Information Center

Ten African-American children, aged five to six, who speak Black English Vernacular were administered three standard English articulation tests. Results showed that a failure to take the issue of dialect variation into account substantially increased the likelihood of misdiagnosing normally speaking African-American children as having articulation…

Cole, Patricia A.; Taylor, Orlando L.

1990-01-01

362

Bicuspid aortic valve endocarditis complicated by mitral valve aneurysm.  

PubMed

We describe a case of mitral valve aneurysm associated with concomitant aortic valve endocarditis. Aneurysms appear as a localized saccular bulge of the anterior leaflet into the left atrium and thus are often misdiagnosed as mitral valve prolapse, myxomatous mitral valve, or atrial myxoma. The presentation and management of mitral valve aneurysms are the subject of this case report.? PMID:21447085

Ruparelia, Neil; Lawrence, David; Elkington, Andrew

2011-05-01

363

Anxiety in Children and Adolescents with Autism Spectrum Disorders  

ERIC Educational Resources Information Center

Anxiety symptoms and disorders are highly prevalent in children and adolescents with Autism Spectrum Disorder (ASD), although they are often unrecognized or misdiagnosed. The purpose of the present review is to (1) provide clinicians with practical information on assessment and diagnosis of co-morbid anxiety in children and adolescents with ASD,…

MacNeil, Bonnie M.; Lopes, Vicki A.; Minnes, Patricia M.

2009-01-01

364

Case Report Double Cancer of the Liver and Lung: A Report of Three Cases  

Microsoft Academic Search

Hepatocellular carcinoma is one of the most common malignancies and, because of the high prevalence of chronic hepatitis B and C, it is the leading cause of death in Taiwan. Lung cancer coexisting with hepatocellular carcinoma has rarely been reported in the medical litera- ture. It might have been misdiagnosed as lung metastasis in many cases. We report three cases

Chien-Yuan Hung; Tsang-En Wang; Wen-Hsiung Chang; Pei-Jan Chen; Tsang-Pai Liu; Jiunn-Chang Lin; Chin-Yin Sheu; Yu-Jan Chen

365

Endogenous bacterial endophthalmitis: A 17-year prospective series and review of 267 reported cases  

Microsoft Academic Search

Endogenous bacterial endophthalmitis is a rare but serious condition that occurs when bacteria cross the blood–ocular barrier and multiply within the eye. We provide an overview of endogenous bacterial endophthalmitis by reviewing 267 reported cases and integrating this with our experience of an additional 19 cases. The majority of patients with endogenous bacterial endophthalmitis are initially misdiagnosed and many have

Timothy L Jackson; Susannah J Eykyn; Elizabeth M Graham; Miles R Stanford

2003-01-01

366

Tenosynovitis caused by a pseudallescheria boydii infection and symptoms of reflex sympathetic dystrophy after a dog bite.  

PubMed

Tenosynovitis caused by a Pseudallescheria boydii infection is an extremely rare complication after a dog bite and is easily misdiagnosed, leading to a delay in treatment. Careful history taking and adequate cultures can lead to a timely diagnosis, and longstanding antimycotic treatment can successfully eradicate the fungus. PMID:21946460

Ruinemans, G Maarten F; Haagsma, Cees J; Hendrix, Ron

2011-10-01

367

IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, VOL. 53, NO. 5, MAY 2006 821 Maximizing Sensitivity in Medical Diagnosis  

E-print Network

medical datasets, the breast-cancer dataset and the heart disease dataset, show that the BMPM outperforms over the "healthy" class, since misdiagnosing a patient as a healthy person may delay the therapy delay the therapy and aggravate the illness. There- fore, the objective in medical diagnosis is inhere

Lyu, Michael R.

368

Sjögren's syndrome, hepatitis C virus and B-Cell lymphoproliferation. Common immunopathogenic mechanisms  

Microsoft Academic Search

The hepatitis C virus (HCV) has a triple tropism: hepatotropism, lymphotropism and sialotropism. Patients with HCV chronic infec- tion present some extrahepatic manifestations that may mimic the cli- nical, immunologic and histological manifestations of primary Sjögrens syndrome (SS). HCV patients with sicca symptomatology and positi- ve autoantibodies could be misdiagnosed as «primary» SS. Neverthe- less, there are several clinical and

M. Ramos-Casals; M. García-Carrasco

369

Detecting Lyme disease using antibody-functionalized carbon nanotubes  

Microsoft Academic Search

We combine antibodies for Lyme flagellar protein with carbon nanotube transistors to create an electronic sensor capable of definitive detection of Lyme disease. Over 35,000 cases of Lyme disease are reported in the United States each year, of which more than 23 percent are originally misdiagnosed. Rational design of the coupling of the biological system to the electronic system gives

Jennifer Dailey; Mitchell Lerner; Brett Goldsmith; Dustin Brisson; A. T. Charlie Johnson

2011-01-01

370

Advanced Clinical Interpretation of the WAIS-IV and WMS-IV: Prevalence of Low Scores Varies by Level of Intelligence and Years of Education  

ERIC Educational Resources Information Center

Clinicians can use the base rates of low scores in healthy people to reduce the likelihood of misdiagnosing cognitive impairment. In the present study, base rates were developed for the Wechsler Adult Intelligence Scale-Fourth Edition (WAIS-IV) and Wechsler Memory Scale-Fourth Edition (WMS-IV) using 900 healthy adults and validated on 28 patients…

Brooks, Brian L.; Holdnack, James A.; Iverson, Grant L.

2011-01-01

371

Lung Cancer Diseases Diagnostic Asistance Using Gray Color Analysis  

Microsoft Academic Search

Errors in diagnosing the disease is a critical risk that must be faced by any person giving treatment to the hospital. Medical treatment can not always be done with perfect accuracy. Lung cancer is one of the most deadly disease that prone to misdiagnose. In general, some practitioners tend to “read” cancer in x-ray rontgen image as tumor this could

P. Paulus; F. L. Gaol

2010-01-01

372

The Impact of Maternal Depressive Symptomatology on Ratings of Children with ADHD and Child Confederates  

ERIC Educational Resources Information Center

Some researchers who have studied children with behavior problems have suggested that depressed mothers distort reports of deviance in their children, perhaps contributing to misdiagnoses; however, investigations studying mothers with current or past depression have not clearly indicated such a bias. Because some of this equivocation may be due to…

Baumann, B. L.; Pelham Jr., W. E.; Lang, A. R.; Jacob, R. G.; Blumenthal, J. D.

2004-01-01

373

Cushing's syndrome or obesity  

Microsoft Academic Search

A rare case of the Cushing syndrome, due to bilateral adrenal hyperplasia is described. Because of generalized obesity, normal height, normal bone age and family history of obesity, a boy 10 years of age had at first been misdiagnosed as simple obesity. A reduction in height velocity, advancement of bone age and development of precocious pseudopuberty led to a more

Annemarie Koelz; Jiirg Girard

1976-01-01

374

Dissociative Disorders in Children: Behavioral Profiles and Problems.  

ERIC Educational Resources Information Center

Clinical research has established a connection between childhood trauma and the development of dissociative disorders in adults. Pathological dissociation produces a range of symptoms and behaviors such as amnesias, rapid shifts in mood and behavior, and auditory and visual hallucinations. Many of these symptoms are misdiagnosed as attention,…

Putnam, Frank W.

1993-01-01

375

Image Guided Decision Support System for Pathology Dorin Comaniciu Peter Meer David J. Foran  

E-print Network

. The classification of Mantle Cell Lymphoma (MCL), a recently described disorder [2, 4], is of particular interest among the indolent lymphomas. MCL is often misdiagnosed as Chronic Lymphocytic Leukemia (CLL) or Follicular Center Cell Lymphoma (FCC) [5]. In addition, the survival of patients with MCL is much shorter

376

Machine Vision and Applications (1999) 11: 213224 Machine Vision and Applications  

E-print Network

cy- tometry. The classification of mantle cell lymphoma (MCL), a recently described disorder [2, 4], is of particular interest among the indolent lymphomas. MCL is often misdiagnosed as chronic lymphocytic leukemia (CLL) or follicular center cell lymphoma (FCC) [5]. In addition, the survival of pa- tients with MCL

377

Fear as the main feature of epileptic seizures  

Microsoft Academic Search

OBJECTIVESThere are circumstances in which partial seizures may be misdiagnosed as acute psychiatric disturbances. In particular, when fear is the prominent feature the patient may be considered for years as having panic attacks. Eight patients in whom fear was the main symptom of the seizures are reported on. Patients who had a proved lack of consciousness during the fits and

A Biraben; D Taussig; P Thomas; C Even; J P Vignal; J M Scarabin; P Chauvel

2001-01-01

378

A plastic whistle incarcerated in bronchus diagnosed fourteen years after ‘swallowed’: a case report  

PubMed Central

Tracheobronchial foreign body aspiration (FBA) is a common disease in pre-school children but easily overlooked by physicians. In this article, we report a case with bronchial stenosis that is not typical and misdiagnosed for 14 years, in the end bronchoscopy retrieval was successfully performed after adequate preparation. Pitfalls and recommendations in diagnosis and management of FBA are briefly included. PMID:24977017

Wang, Xin

2014-01-01

379

Carbon monoxide poisoning — a public health perspective  

Microsoft Academic Search

Carbon monoxide (CO) may be the cause of more than one-half of the fatal poisonings reported in many countries; fatal cases also are grossly under-reported or misdiagnosed by medical professionals. Therefore, the precise number of individuals who have suffered from CO intoxication is not known. The health effects associated with exposure to CO range from the more subtle cardiovascular and

James A. Raub; Monique Mathieu-Nolf; Neil B. Hampson; Stephen R. Thom

2000-01-01

380

Spinal Canal Block Caused by Central Disc Protrusion.  

National Technical Information Service (NTIS)

Central disc protrusions are often misdiagnosed as other lesions, particularly those with block of spinal canal. Between October 1970 and February 1978 the author had 15 cases of spinal canal block due to central disc protrusions. Of these, 5 cases were i...

Z. Rongxun

1980-01-01

381

A Silent Hurt.  

ERIC Educational Resources Information Center

The Autism Research Institute says autism-like disorders affect 15 out of 10,000 children. Cases are climbing in schools, partly due to expanded diagnostic codes (see sidebar). Autistic children are often misdiagnosed as having attention-deficit, learning, or emotional disorders. Schools can help by providing good teachers and early intervention.…

Black, Susan

2000-01-01

382

Long term video\\/EEG prevents unnecessary vagus nerve stimulator implantation in patients with psychogenic nonepileptic seizures  

Microsoft Academic Search

ObjectivePsychogenic nonepileptic seizures (PNES) are common paroxysmal events that mimic and can often be misdiagnosed as epileptic seizures. PNES account for 10 to 40% of patients referred to epilepsy centers. Patients with uncontrolled PNES are at times subjected to vagus nerve stimulator (VNS) implantation. We report a series of such referred patients studied with video\\/EEG monitoring at our institution.

Amir M. Arain; Yanna Song; Nandakumar Bangalore-Vittal; Shahid Ali; Shagufta Jabeen; Nabil J. Azar

2011-01-01

383

Depression on Dialysis  

Microsoft Academic Search

Depression is the most common psychopathological condition among patients with end-stage renal disease (ESRD), yet it is still under-recognized and misdiagnosed. Depression reduces quality of life and has a negative clinical impact upon sufferers with chronic illness, including ESRD. This article discusses the negative effects of depression among the ESRD population treated with dialysis, the prevalence of the condition, the

Joseph Chilcot; David Wellsted; Maria Da Silva-Gane; Ken Farrington

2008-01-01

384

Male Anorexia Nervosa: A New Focus.  

ERIC Educational Resources Information Center

Although anorexia nervosa affects over one million males yearly, it is often misdiagnosed or overlooked by mental health and medical practitioners. This article brings the problem to the forefront and outlines features that are unique to these males. Greater recognition of the disorder can lead to more accurate diagnoses and, subsequently, better…

Crosscope-Happel, Cindy; Hutchins, David E.; Getz, Hildy G.; Hayes, Gerald L.

2000-01-01

385

BIPOLAR DISORDER: MAKING THE DIAGNOSIS AND EXPLORING THE BIOLOGICAL ORIGINS  

Microsoft Academic Search

By conservative estimates, bipolar disorder affects 2.3 million Americans, and is frequently misdiagnosed, with individuals reporting seeing an average of 4 physicians before receiving the proper diagnosis and treatment. This may be due to the fact that the symptoms of bipolar disorder comprise a mood spectrum, running the gamut from depressive episodes to mania, with periods of euthymia and, in

Scott P. Hoopes

386

The use of Mood Disorder Questionnaire, Hypomania Checklist32 and clinical predictors for screening previously unrecognised bipolar disorder in a general psychiatric setting  

Microsoft Academic Search

Bipolar disorder is often unrecognised and misdiagnosed in the general psychiatric setting. This study compared the psychometric properties of Mood Disorder Questionnaire (MDQ) and Hypomania Checklist-32 (HCL-32), examined the clinical predictors of bipolar disorder and determined the best approach for screening previously unrecognised bipolar disorder in a general psychiatric clinic. A random sample of 340 non-psychotic outpatients with no previous

Yvette Poon; Ka-Fai Chung; Kwok-Chu Tso; Chi-Lok Chang; Dorothy Tang

387

Full Body Gait Analysis May Improve Diagnostic Discrimination Between Hereditary Spastic Paraplegia and Spastic Diplegia: A Preliminary Study  

ERIC Educational Resources Information Center

Hereditary spastic paraplegia (HSP) and spastic diplegia (SD) patients share a strong clinical resemblance. Thus, HSP patients are frequently misdiagnosed with a mild form of SD. Clinical gait analysis (CGA) has been highlighted as a possible tool to support the differential diagnosis of HSP and SD. Previous analysis has focused on the lower-body…

Bonnefoy-Mazure, A.; Turcot, K.; Kaelin, A.; De Coulon, G.; Armand, S.

2013-01-01

388

Chapter 12: Congenital Rubella Syndrome  

Microsoft Academic Search

Rubella is a viral illness caused by a togavirus of the genus Rubivirus and is characterized by a mild, maculopapular rash. The rubella rash is sometimes misdiagnosed as measles or scarlet fever and occurs in up to 50% of rubella- infected persons. Children usually develop few or no constitutional symptoms, but adults may experience a 1-5 day prodrome of low-grade

Susan Reef; Victor Coronado; Laura Zimmerman-Swain

1999-01-01

389

North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition Consensus Statement on the Diagnosis and Management of Cyclic Vomiting Syndrome  

Microsoft Academic Search

Cyclic vomiting syndrome (CVS) is a disorder noted for its unique intensity of vomiting, repeated emergency department visits and hospitalizations, and reduced quality of life. It is often misdiagnosed due to the unappreciated pattern of recurrence and lack of confirmatory testing. Because no accepted approach to management has been established, the task force was charged to develop a report on

B UK Li; Frank Lefevre; Gisela G Chelimsky; Richard G Boles; Susanne P Nelson; Donald W Lewis; Steven L Linder; Robert M Issenman; Colin D Rudolph

2008-01-01

390

[Erroneous diagnosis of subperiosteal osteoid osteoma: value of imaging techniques?].  

PubMed

A case of subperiosteal osteoid osteoma of the tibia misdiagnosed as stress fracture based on a history of multiple trauma and the results at MRI and bone scintigraphy is described. The nidus was well demonstrated at CT and the diagnosis was confirmed at histology. The role of different imaging techniques and their pitfalls are discussed. PMID:10592915

Farrokh, D

1999-11-01

391

Cerebral macroabscess caused by Candida albicans in an immunocompetent patient: A diagnostic challenge  

PubMed Central

We describe the history of a 24-year-old immunocompetent man with an expansive lesion in the brainstem that, after many misdiagnoses, was found to be caused by a Candida albicans abscess. One year after surgery and 3 months of fluconazole treatment, the patient was asymptomatic and all image and laboratory tests were normal. PMID:24567895

Figueiredo, Sonia M.; Campolina, Sabrina; Rosa, Carlos A.; Gontijo, Marcus; Tirone, Thelma; Assuncao, Claudia B.; Freire, Tarcisio F.A.; Christo, Paulo P.; Caligiorne, Rachel B.

2014-01-01

392

Inclusion body myositis: an underdiagnosed myopathy of older people  

Microsoft Academic Search

Inclusion body myositis (IBM), a condition characterised by progressive muscle weakness and inclusion bodies visible on muscle biopsy, is the most common type of myopathy in patients over 50 years of age. However, it is not only under diag- nosed but frequently misdiagnosed as polymyositis and hence wrongly treated with steroids. In the evaluation of progressive weakness in older Caucasian

SUNIL K. MUNSHI; BHOMRAJ THANVI; S. J. JONNALAGADDA; PHILIP DA FORNO; ASHISH PATEL; SAROO SHARMA

393

Foundation Phase Educators' Perceptions of Attention Deficit Hyperactivity Disorder at a Mainstream Primary School  

ERIC Educational Resources Information Center

Although Attention Deficit Hyperactivity Disorder (ADHD) is one of the most diagnosed conditions in children, it is also one of the misunderstood and misdiagnosed syndromes. The aim of this study was to investigate the perceptions of foundation phase educators about ADHD, specifically their views on its causes, appropriate interventions and…

Seabi, J.

2010-01-01

394

A Novel and Effective Treatment Modality for Medically Unexplained Symptoms  

Microsoft Academic Search

Medically unexplained symptoms (MUS) confound physicians, and the incidence and prevalence of these conditions is poorly documented. This is not least due to the complex nature of MUS and mimicry of morbidity with conditions that have common clinical assessment and treatment modalities, e.g. migraine headaches which stress headaches commonly are misdiagnosed as. Effective treatment modalities for MUS have been more

Richard Evan Steele; Evelyne de Leeuw; David O. Carpenter

395

The psychological burden of an initially unexplained illness: patients with sternocostoclavicular hyperostosis before and after delayed diagnosis  

Microsoft Academic Search

BACKGROUND: Sternocostoclavicular hyperostosis (SCCH) is a rare, debilitating, chronic inflammatory disorder of the anterior chest wall due to a chronic sterile osteomyelitis of unknown origin. SCCH is largely underdiagnosed and often misdiagnosed. In individual cases it can remain unrecognized for years. The purpose of this study is twofold. Firstly, to evaluate the psychological condition of SCCH patients, both in the

Willem A van der Kloot; Neveen AT Hamdy; Laurian CS Hafkemeijer; Femke MC den Dulk; Sadhna A Chotkan; Arnold AP van Emmerik; Ad A Kaptein

2010-01-01

396

Identifying Functional Neuroimaging Biomarkers of Bipolar Disorder: Toward DSM-V  

Microsoft Academic Search

Bipolar disorder is one of the most debilitating and com- mon illnesses worldwide. Individuals with bipolar disorder frequently present to clinical services when depressed but are often misdiagnosed with unipolar depression, leading to inadequate treatment and poor outcome. Increased ac- curacy in diagnosing bipolar disorder, especially during depression, is therefore a key long-term goal to improve the mental health of

Mary L. Phillips; Eduard Vieta

2007-01-01

397

Endometrial metaplasias and reactive changes: a spectrum of altered differentiation  

Microsoft Academic Search

Endometrial metaplasias and changes (EMCs) are conditions frequently overlooked and misdiagnosed. The aim of this review is to update current issues and provide a classification with a practical clinicopathological approach. Hormonal or irritative stimuli are the main inducing factors of EMCs, although some metaplasias have a mutational origin. EMCs vary from reactive, degenerative lesions to those able to associate with

Alina Nicolae; Ovidiu Preda; Francisco F Nogales

2010-01-01

398

Kirit C. Shah, M.D. v. Stan Harris and Nancy Harris. "Construction of Legal Arguments, Statutes of Limitations, and Medical Malpractice." Lesson Plans for Secondary Teachers on How Lawyers Prepare Their Arguments. Courts in the Classroom: Curriculum Concepts and Other Information on Indiana's Courts for the K-12 Educator.  

ERIC Educational Resources Information Center

Stan and Nancy Harris filed a complaint against Kirit C. Shah, M.D., for misdiagnosing Mr. Harris's illness, charging Dr. Shah with negligence and asking for damages. A medical malpractice action in Indiana is governed by a two year statute of limitations. Because the Harrises failed to bring their action against Dr. Shah within this two year…

Osborn, Elizabeth

399

Cystic extra-axial cavernoma of the cerebellopontine angle  

Microsoft Academic Search

Besides acoustic neuromas, the cerebellopontine angle harbors a wide variety of masses, named “nonacoustic neuroma tumors,” as a whole. Although magnetic resonance imaging has much improved our ability to differentiate among posterior fossa lesions, misdiagnoses may still occur when facing rare, controversial cases.

Andrea Brunori; Francesco Chiappetta

1996-01-01

400

African American English: Dialect Mistaken As an Articulation Disorder  

Microsoft Academic Search

The purpose of this literature review is to discuss the reasons speech-language pathologists often misdiagnose children using AAE as having articulation and phonological disorders. In my literature review, I will discuss three ruling explanations for why this problem occurs. The most common reason for this misdiagnosis is that speech-language pathologists (SLPs) are unfamiliar with AAE acquisition and its phonological features.

Sade Wilson

2012-01-01

401

Computed tomography in the diagnosis of malignant brain tumours: do all patients require biopsy?  

Microsoft Academic Search

A proportion of patients with computed tomographic (CT) scan appearances of malignant brain tumour undergo conservative management, despite the absence of histological confirmation of the diagnosis. Concern that this policy risked misdiagnosing a benign tumour prompted us to examine the accuracy of CT scanning in diagnosing malignant lesions. The study was designed to determine whether within a group of 300

M S Choksey; A Valentine; H Shawdon; C E Freer; K W Lindsay

1989-01-01

402

Primary myelolipoma of the lung: a case of report and review of literature.  

PubMed

Myelolipoma of the lung is a rare benign tumor composed of mature adipose tissue and normal hematopoietic cells. Only 8 cases of primary myelolipoma of the lung have been reported up to date. We report here the ninth case which was misdiagnosed as a malignant tumor and relevant literature is reviewed. PMID:23161239

Huang, Wenbin; Zhao, Youcai; Yin, Xindao; Qi, Qiong

2012-11-01

403

Complex transient epileptic amnesia  

Microsoft Academic Search

Transient epileptic amnesia is a rare but probably underrecognized form of temporal lobe epilepsy, which typically manifests as episodic isolated memory loss. Consequently, transient epileptic amnesia may be readily misdiagnosed as a nonepileptic memory dysfunction in older individuals. When appropriately recognized, it has been described as a treatment-responsive syndrome amenable to antiepileptic drugs. We describe a patient with drug-resistant transient

Ryan D. Walsh; Robert E. Wharen; William O. Tatum

2011-01-01

404

Rare adipose disorders (RADs) masquerading as obesity  

Microsoft Academic Search

Rare adipose disorders (RADs) including multiple symmetric lipomatosis (MSL), lipedema and Dercum's disease (DD) may be misdiagnosed as obesity. Lifestyle changes, such as reduced caloric intake and increased physical activity are standard care for obesity. Although lifestyle changes and bariatric surgery work effectively for the obesity component of RADs, these treatments do not routinely reduce the abnormal subcutaneous adipose tissue

Karen L Herbst

2012-01-01

405

Lacrimal canaliculitis  

PubMed Central

Canaliculitis is an uncommon, often misdiagnosed diagnosis because canaliculitis can mimic many other common ocular conditions. Canaliculitis should be appropriately diagnosed and treated to avoid recurrent inflammation and possible obstruction of the upper portion of the lacrimal system. This review will serve as a concise resource to aid in diagnosis and provide updated management options. PMID:24526851

Zaveri, Jill; Cohen, Adam J.

2013-01-01

406

Medial or lateral dislocation (snapping) of a portion of the distal triceps: A biomechanical, anatomic explanation  

Microsoft Academic Search

Medial and lateral snapping (dislocation) of the distal triceps over the epicondyle during elbow flexion has been reported but is frequently misdiagnosed and is not well understood. In this study a mathematical model was designed to simulate the effect that bony abnormalities at the distal humerus and soft tissue variations of the distal triceps have on the line of pull

Robert J. Spinner; Kai-Nan An; Kyu-Jung Kim; Richard D. Goldner; Shawn W. O'Driscoll

2001-01-01

407

Randomised primary health center based interventions to improve the diagnosis and treatment of undifferentiated fever and dengue in Vietnam  

Microsoft Academic Search

BACKGROUND: Fever is a common reason for attending primary health facilities in Vietnam. Response of health care providers to patients with fever commonly consists of making a presumptive diagnosis and proposing corresponding treatment. In Vietnam, where malaria was brought under control, viral infections, notably dengue, are the main causes of undifferentiated fever but they are often misdiagnosed and inappropriately treated

Hoang L Phuong; Tran TT Nga; Phan T Giao; Le Q Hung; Tran Q Binh; Nguyen V Nam; Nico Nagelkerke; Peter J de Vries

2010-01-01

408

Tracking a Medically Important Spider: Climate Change, Ecological Niche Modeling, and the Brown Recluse (Loxosceles reclusa)  

Microsoft Academic Search

Most spiders use venom to paralyze their prey and are commonly feared for their potential to cause injury to humans. In North America, one species in particular, Loxosceles reclusa (brown recluse spider, Sicariidae), causes the majority of necrotic wounds induced by the Araneae. However, its distributional limitations are poorly understood and, as a result, medical professionals routinely misdiagnose brown recluse

Erin E. Saupe; Monica Papes; Paul A. Selden; Richard S. Vetter; Corrie Moreau

2011-01-01

409

Parasitic Infections Based on 320 Clinical Samples Submitted to Hanyang University, Korea (2004-2011)  

PubMed Central

We analyzed 320 clinical samples of parasitic infections submitted to the Department of Environmental Biology and Medical Parasitology, Hanyang University from January 2004 to June 2011. They consisted of 211 nematode infections, 64 trematode or cestode infections, 32 protozoan infections, and 13 infections with arthropods. The nematode infections included 67 cases of trichuriasis, 62 of anisakiasis (Anisakis sp. and Pseudoterranova decipiens), 40 of enterobiasis, and 24 of ascariasis, as well as other infections including strongyloidiasis, thelaziasis, loiasis, and hookworm infecions. Among the cestode or trematode infections, we observed 27 cases of diphyllobothriasis, 14 of sparganosis, 9 of clonorchiasis, and 5 of paragonimiasis together with a few cases of taeniasis saginata, cysticercosis cellulosae, hymenolepiasis, and echinostomiasis. The protozoan infections included 14 cases of malaria, 4 of cryptosporidiosis, and 3 of trichomoniasis, in addition to infections with Entamoeba histolytica, Entamoeba dispar, Entamoeba coli, Endolimax nana, Giardia lamblia, and Toxoplasma gondii. Among the arthropods, we detected 6 cases of Ixodes sp., 5 of Phthirus pubis, 1 of Sarcoptes scabiei, and 1 of fly larva. The results revealed that trichuriasis, anisakiasis, enterobiasis, and diphyllobothriasis were the most frequently found parasitosis among the clinical samples. PMID:24850969

Choi, Sung-Chul; Lee, Soo-Young; Song, Hyun-Ouk; Ryu, Jae-Sook

2014-01-01

410

Parasitic infections based on 320 clinical samples submitted to Hanyang University, Korea (2004-2011).  

PubMed

We analyzed 320 clinical samples of parasitic infections submitted to the Department of Environmental Biology and Medical Parasitology, Hanyang University from January 2004 to June 2011. They consisted of 211 nematode infections, 64 trematode or cestode infections, 32 protozoan infections, and 13 infections with arthropods. The nematode infections included 67 cases of trichuriasis, 62 of anisakiasis (Anisakis sp. and Pseudoterranova decipiens), 40 of enterobiasis, and 24 of ascariasis, as well as other infections including strongyloidiasis, thelaziasis, loiasis, and hookworm infecions. Among the cestode or trematode infections, we observed 27 cases of diphyllobothriasis, 14 of sparganosis, 9 of clonorchiasis, and 5 of paragonimiasis together with a few cases of taeniasis saginata, cysticercosis cellulosae, hymenolepiasis, and echinostomiasis. The protozoan infections included 14 cases of malaria, 4 of cryptosporidiosis, and 3 of trichomoniasis, in addition to infections with Entamoeba histolytica, Entamoeba dispar, Entamoeba coli, Endolimax nana, Giardia lamblia, and Toxoplasma gondii. Among the arthropods, we detected 6 cases of Ixodes sp., 5 of Phthirus pubis, 1 of Sarcoptes scabiei, and 1 of fly larva. The results revealed that trichuriasis, anisakiasis, enterobiasis, and diphyllobothriasis were the most frequently found parasitosis among the clinical samples. PMID:24850969

Choi, Sung-Chul; Lee, Soo-Young; Song, Hyun-Ouk; Ryu, Jae-Sook; Ahn, Myoung-Hee

2014-04-01

411

Serodiagnosis of Toxocariasis by ELISA Using Crude Antigen of Toxocara canis Larvae  

PubMed Central

Toxocariasis is a worldwide zoonosis caused by larvae of ascarid nematodes of dogs or cats, Toxocara canis or T. cati. Diagnosis of human toxocariasis currently relies on serology that uses T. canis excretory-secretory antigen to detect specific IgG antibodies by ELISA. We investigated the serodiagnostic efficacy of ELISA using crude antigen of T. canis larvae (TCLA). Serum specimens of 64 clinically confirmed toxocariasis, 115 healthy controls, and 119 other tissue-invading helminthiases were screened by ELISA using TCLA. The ELISA using TCLA showed 92.2% (59/64 patient samples) sensitivity and 86.6% (103/119) specificity. Its positive diagnostic predictivity was 78.7% and negative predictivity was 97.8%. No serum of healthy controls reacted but that of anisakiasis (45.5%), gnathostomiasis (19.2%), clonorchiasis (15.8%), sparganosis (11.1%), and cysticercosis (6.3%) cross-reacted. Immunoblot analysis on TCLA recognized antigenic proteins of 28- and 30-kDa bands in their dominant protein quantity and strong blotting reactivity. The present results indicate that the ELISA using our TCLA antigen is acceptable by the sensitivity and specificity for serodiagnosis of human toxocariasis. ELISA with TCLA is recommended to make differential diagnosis for patients with any sign of organ infiltration and eosinophilia. PMID:24039286

Jin, Yan; Shen, Chenghua; Huh, Sun; Sohn, Woon-Mok; Choi, Min-Ho

2013-01-01

412

Cutaneous Gnathostomiasis with Recurrent Migratory Nodule and Persistent Eosinophilia: a Case Report from China  

PubMed Central

The present study reports a human case of cutaneous gnathostomiasis with recurrent migratory nodule and persistent eosinophilia in China. A 52-year-old woman from Henan Province, central China, presented with recurrent migratory reddish swelling and subcutaneous nodule in the left upper arm and on the back for 3 months. Blood examination showed eosinophila (21.2%), and anti-sparganum antibodies were positive. Skin biopsy of the lesion and histopathological examinations revealed dermal infiltrates of eosinophils but did not show any parasites. Thus, the patient was first diagnosed as sparganosis; however, new migratory swellings occurred after treatment with praziquantel for 3 days. On further inquiring, she recalled having eaten undercooked eels and specific antibodies to the larvae of Gnathostoma spinigerum were detected. The patient was definitely diagnosed as cutaneous gnathostomiasis caused by Gnathostoma sp. and treated with albendazole (1,000 mg/day) for 15 days, and the subsequent papule and blister developed after the treatment. After 1 month, laboratory findings indicated a reduced eosinophil count (3.3%). At her final follow-up 18 months later, the patient had no further symptoms and anti-Gnathostoma antibodies became negative. Conclusively, the present study is the first report on a human case of cutaneous gnathostomiasis in Henan Province, China, based on the past history (eating undercooked eels), clinical manifestations (migratory subcutaneous nodule and persistent eosinophilia), and a serological finding (positive for specific anti-Gnathostoma antibodies). PMID:24039291

Cui, Jing; Wang, Ye

2013-01-01

413

Zoonotic helminths affecting the human eye  

PubMed Central

Nowaday, zoonoses are an important cause of human parasitic diseases worldwide and a major threat to the socio-economic development, mainly in developing countries. Importantly, zoonotic helminths that affect human eyes (HIE) may cause blindness with severe socio-economic consequences to human communities. These infections include nematodes, cestodes and trematodes, which may be transmitted by vectors (dirofilariasis, onchocerciasis, thelaziasis), food consumption (sparganosis, trichinellosis) and those acquired indirectly from the environment (ascariasis, echinococcosis, fascioliasis). Adult and/or larval stages of HIE may localize into human ocular tissues externally (i.e., lachrymal glands, eyelids, conjunctival sacs) or into the ocular globe (i.e., intravitreous retina, anterior and or posterior chamber) causing symptoms due to the parasitic localization in the eyes or to the immune reaction they elicit in the host. Unfortunately, data on HIE are scant and mostly limited to case reports from different countries. The biology and epidemiology of the most frequently reported HIE are discussed as well as clinical description of the diseases, diagnostic considerations and video clips on their presentation and surgical treatment. Homines amplius oculis, quam auribus credunt Seneca Ep 6,5 Men believe their eyes more than their ears PMID:21429191

2011-01-01

414

Pathology of CNS parasitic infections.  

PubMed

Parasitic infections of the central nervous system (CNS) include two broad categories of infectious organisms: single-celled protozoa and multicellular metazoa. The protozoal infections include malaria, American trypanosomiasis, human African trypanosomiasis, toxoplasmosis, amebiasis, microsporidiasis, and leishmaniasis. The metazoal infections are grouped into flatworms, which include trematoda and cestoda, and roundworms or nematoda. Trematoda infections include schistosomiasis and paragonimiasis. Cestoda infections include cysticercosis, coenurosis, hydatidosis, and sparganosis. Nematoda infections include gnathostomiasis, angiostrongyliasis, toxocariasis, strongyloidiasis, filariasis, baylisascariasis, dracunculiasis, micronemiasis, and lagochilascariasis. The most common route of CNS invasion is through the blood. In some cases, the parasite invades the olfactory neuroepithelium in the nasal mucosa and penetrates the brain via the subarachnoid space or reaches the CNS through neural foramina of the skull base around the cranial nerves or vessels. The neuropathological changes vary greatly, depending on the type and size of the parasite, geographical strain variations in parasitic virulence, immune evasion by the parasite, and differences in host immune response. Congestion of the leptomeninges, cerebral edema, hemorrhage, thrombosis, vasculitis, necrosis, calcification, abscesses, meningeal and perivascular polymorphonuclear and mononuclear inflammatory infiltrate, microglial nodules, gliosis, granulomas, and fibrosis can be found affecting isolated or multiple regions of the CNS, or even diffusely spread. Some infections may be present as an expanding mass lesion. The parasites can be identified by conventional histology, immunohistochemistry, in situ hybridization, and PCR. PMID:23829901

Pittella, José Eymard Homem

2013-01-01

415

Praziquantel Treatment in Trematode and Cestode Infections: An Update  

PubMed Central

Status and emerging issues in the use of praziquantel for treatment of human trematode and cestode infections are briefly reviewed. Since praziquantel was first introduced as a broadspectrum anthelmintic in 1975, innumerable articles describing its successful use in the treatment of the majority of human-infecting trematodes and cestodes have been published. The target trematode and cestode diseases include schistosomiasis, clonorchiasis and opisthorchiasis, paragonimiasis, heterophyidiasis, echinostomiasis, fasciolopsiasis, neodiplostomiasis, gymnophalloidiasis, taeniases, diphyllobothriasis, hymenolepiasis, and cysticercosis. However, Fasciola hepatica and Fasciola gigantica infections are refractory to praziquantel, for which triclabendazole, an alternative drug, is necessary. In addition, larval cestode infections, particularly hydatid disease and sparganosis, are not successfully treated by praziquantel. The precise mechanism of action of praziquantel is still poorly understood. There are also emerging problems with praziquantel treatment, which include the appearance of drug resistance in the treatment of Schistosoma mansoni and possibly Schistosoma japonicum, along with allergic or hypersensitivity reactions against praziquantel treatment. To cope with and overcome these problems, combined use of drugs, i.e., praziquantel and other newly introduced compounds such as triclabendazole, artemisinins, and tribendimidine, is being tried. PMID:24265948

2013-01-01

416

Progress in the clinical imaging research of bone diseases on ankle and foot sesamoid bones and accessory ossicles  

PubMed Central

Summary Sesamoid bones and accessory ossicles are research focuses of foot and ankle surgery. Pains of the foot and ankle are related to sesamoid bones and accessory ossicles. The specific anatomical and functional relationship of sesamoid bones and accessory ossicles can cause such bone diseases as the dislocation of sesamoid bones and accessory bones, infection, inflammation and necrosis of sesamoid bones, cartilage softening, tenosynovitis of sesamoid bones and the sesamoid bone syndrome. However, these bone diseases are often misdiagnosed or mistreated. In patients with trauma history, relevant diseases of sesamoid bones and accessory ossicles as above mentioned are highly probable to be misdiagnosed as avulsion fractures. In such cases, radiographic findings may provide a basis for clinical diagnosis.

Li, Xiaozhong; Shi, Lenian; Liu, Taiyun; Wang, Lin

2012-01-01

417

Acute Spontaneous Spinal Subdural Hematoma with Vague Symptoms  

PubMed Central

Spinal subdural hematoma is a rarely reported disease and spontaneous spinal subdural hematomas (SSDH) without underlying pathological changes are even rarer. The patients usually show typical symtoms such as back pain, quadriplegia, paraplegia or sensory change. But rarely, patients may show atypical symptoms such as hemiparesis and misdiagnosed to cerebrovascular accident. We recently experienced a case of SSDH, where the patient initially showed vague symptoms, such as the sudden onset of headache which we initially misdiagnosed as subarachnoid hemorrhage. In this case, the headache of patient improved but the neck pain persisted until hospital day 5. Therefre, we conducted the MRI of cervical spine and finally confirmed SSDH. The patient was managed conservatively and improved without recurrence. In this case report, we discuss the clinical features of SSDH with emphasis on the importance of an early diagnosis. PMID:25368774

Chung, Jaehwan; Hwang, Soo-Hyun; Han, Jong-Woo

2014-01-01

418

Dermoscopy Findings of Hidroacanthoma Simplex  

PubMed Central

Hidroacanthoma simplex (HAS), also known as intraepidermal eccrine poroma, is a rare eccrine adnexal tumor that tends to be misdiagnosed as other types of benign skin tumor, including clonal seborrheic keratosis. Notably, HAS is sometimes misdiagnosed and treated by cryosurgery as seborrheic keratosis, which could trigger the later development of porocarcinoma. Therefore, accurate diagnosis of HAS is indispensable for dermatologists to avoid the development of malignant tumors by an unsuitable treatment. In this report, we present the characteristic dermoscopy findings of HAS. Indeed, the dermoscopy findings might be related to the melanin-rich necrotic cells in the epidermis, which are quite different from dermoscopy findings of clonal seborrheic keratosis. As a previous report suggested, it is difficult for a dermatologist to differentiate HAS from clonal seborrheic keratosis by the naked eye. Our findings might be supportive for the early diagnosis of HAS. PMID:24987351

Sato, Yota; Fujimura, Taku; Tamabuchi, Erika; Haga, Takahiro; Aiba, Setsuya

2014-01-01

419

Pulmonary histoplasmosis in a renal allograft recipient  

PubMed Central

Histoplasmosis, seen rarely in kidney transplantracipients, can vary from an innocuous illness often misdiagnosed as tuberculosis to a severe disseminated disease with a high mortality. We describe a case with non-specific signs in whom the diagnosis was made by histopathological examination of the lesion. Prompt introduction of specific treatment led to Histoplasmosis, seen rarely in kidney transplantracipients, can vary from an innocuous illness often misdiagnosed as tuberculosis to a severe disseminated disease with a high mortality. We describe a case with non-specific signs in whom the diagnosis was made by histopathological examination of the lesion. Prompt introduction of specific treatment led to the patient making an excellent recovery the patient making an excellent recovery. PMID:24701047

Lobo, V.; Joshi, A.; Khatavkar, P.; Kale, M. K.

2014-01-01

420

[Tick borne diseases].  

PubMed

It is known for many years that tick-borne diseases have worldwide a high economical impact on farming industry and veterinary medicine. But only in the last twenty years the importance of such diseases were notified in human medicine by the medical community and the public with emerging of the tick borne encephalitis virus and the description of Borrelia burgdorferi. It is often forgotten that many other infectious agents as bacteria, virus, Rickettsia or protozoa can be transmitted by ticks. Such diseases are rarely diagnosed in Europe either they are overlooked and misdiagnosed or they are connected with special professional activities. The development of new regions for tourism with different out door activities (adventure trips, trekking, hunting) leads to an exposure to different tick borne diseases, which are often misdiagnosed. PMID:16350539

Holzer, B R

2005-11-01

421

Rectus sheath hematoma: three case reports  

PubMed Central

Introduction Rectus sheath hematoma is an uncommon cause of acute abdominal pain. It is an accumulation of blood in the sheath of the rectus abdominis, secondary to rupture of an epigastric vessel or muscle tear. It could occur spontaneously or after trauma. They are usually located infraumblically and often misdiagnosed as acute abdomen, inflammatory diseases or tumours of the abdomen. Case presentation We reported three cases of rectus sheath hematoma presenting with a mass in the abdomen and diagnosed by computerized tomography. The patients recovered uneventfully after bed rest, intravenous fluid replacement, blood transfusion and analgesic treatment. Conclusion Rectus sheath hematoma is a rarely seen pathology often misdiagnosed as acute abdomen that may lead to unnecessary laparotomies. Computerized tomography must be chosen for definitive diagnosis since ultrasonography is subject to error due to misinterpretation of the images. Main therapy is conservative management. PMID:18221529

Kapan, Selin; Turhan, Ahmet N; Alis, Halil; Kalayci, Mustafa U; Hatipoglu, Sinan; Yigitbas, Hakan; Aygun, Ersan

2008-01-01

422

Cryotherapy for massive vulvar lymphatic leakage complicated with lymphangiomas following gynecological cancer treatment.  

PubMed

Vulvar lymphatic leakage is a severe complication associated with gynecological cancer treatments. However, standard treatment strategies have not yet been determined. We encountered a rare case of a 76-year-old multiparous woman suffering from massive lymphatic fluid leakage from the entire vulva, and papules developed and were identified as lymphangiomas. A large amount of straw-colored discharge continued from all vulvar papules, which extended over the mons pubis. Nine years ago, the patient had undergone a radical hysterectomy with concurrent chemoradiation for uterine cervical cancer treatment. Her serum albumin level was 1.9 mg/dl, which was attributed to the loss of a large amount of lymph fluid due to leakage from the vulva. Her quality of life gradually decreased because of general fatigue and the need for frequent diaper exchanges every 2 h. The patient received a less-invasive treatment with cryotherapy using liquid nitrogen. She also received a multimodality treatment consisting of the intravenous administration of albumin, massage of the lower limbs and intensive rehabilitation. Cryotherapy was administered once a week for 3 months. Her discharge almost stopped and vulvar lymphangiomas decreased without any major complications. To the best of our knowledge, this is the first case report of massive lymphatic leakage complicated with vulvar lymphangiomas. Additionally, this case may represent the first successful treatment of vulva lymph leakage by cryotherapy without recurrence. Cryotherapy may have the potential to improve the quality of life as a less-invasive treatment for gynecological cancer survivors without serious complications. PMID:25190008

Yanazume, Shintaro; Douzono, Haruhiko; Kubo, Hidemichi; Nagata, Tomomi; Douchi, Tsutomu; Kobayashi, Hiroaki

2014-11-01

423

Primary Localization and Tumor Thickness as Prognostic Factors of Survival in Patients with Mucosal Melanoma  

PubMed Central

Background Data on survival with mucosal melanoma and on prognostic factors of are scarce. It is still unclear if the disease course allows for mucosal melanoma to be treated as primary cutaneous melanoma or if differences in overall survival patterns require adapted therapeutic approaches. Furthermore, this investigation is the first to present 10-year survival rates for mucosal melanomas of different anatomical localizations. Methodology 116 cases from Sep 10 1984 until Feb 15 2011 retrieved from the Comprehensive Cancer Center and of the Central Register of the German Dermatologic Society databases in Tübingen were included in our analysis. We recorded anatomical location and tumor thickness, and estimated overall survival at 2, 5 and 10 years and the mean overall survival time. Survival times were analyzed with the Kaplan-Meier method. The log-rank test was used to compare survival times by localizations and by T-stages. Principal Findings We found a median overall survival time of 80.9 months, with an overall 2-year survival of 71.7%, 5-year survival of 55.8% and 10-year survival of 38.3%. The 10-year survival rates for patients with T1, T2, T3 or T4 stage tumors were 100.0%, 77.9%, 66.3% and 10.6% respectively. 10-year survival of patients with melanomas of the vulva was 64.5% in comparison to 22.3% of patients with non-vulva mucosal melanomas. Conclusion Survival times differed significantly between patients with melanomas of the vulva compared to the rest (p?=?0.0006). It also depends on T-stage at the time of diagnosis (p<0.0001). PMID:25383553

Mehra, Tarun; Grozinger, Gerd; Mann, Steven; Guenova, Emmanuella; Moos, Rudolf; Rocken, Martin; Claussen, Claus Detlef; Dummer, Reinhard; Clasen, Stephan

2014-01-01

424

[Avulsion fracture of the lesser trochanter].  

PubMed

An avulsion fracture of the lesser trochanter is a very rare injury often misdiagnosed as a muscle lesion or hip distortion. This report concerns the avulsion fracture of the lesser trochanter of a 13-year-old boy, suffered on a runway preparing for a long jump. Conservative treatment without weight-bearing was indicated for 6 weeks. Twelve weeks after the injury the patient resumed his normal sport activities. PMID:22437376

Ruffing, T; Danko, T; Muhm, M; Arend, G; Winkler, H

2012-07-01

425

Caseous calcification of the mitral annulus: case report.  

PubMed

We present a rare case of probable caseous calcification of the mitral. This pathology is more frequently detected in asymptomatic women older than 70 years. To recognize this image is important because echocardiography is the easiest way to elucidate this diagnosis, and more importantly because this structure could be easily misdiagnosed as tumors, thrombus and vegetations, which are much more common. Normally, it has a benign evolution, and the correct diagnosis is crucial to avoid unnecessary surgical interventions. PMID:24136767

França, Lucas Arraes de; Rodrigues, Ana Clara Tude; Vieira, Marcelo Luiz Campos; Oliveira, Wércules Antônio Alves de; Azevedo, Rudyney Eduardo Uchôa de; Cordovil, Adriana; Lira-Filho, Edgar Bezerra de; Fischer, Claudio Henrique; Morhy, Samira Saady

2013-01-01

426

Mucopolysaccharidosis type III (Sanfilippo syndrome) and misdiagnosis of idiopathic developmental delay, attention deficit/hyperactivity disorder or autism spectrum disorder  

PubMed Central

Mucopolysaccharidosis III is a rare genetic disease characterized by progressive cognitive decline and severe hyperactivity that does not respond to stimulants. Somatic features are relatively mild. Patients are often initially misdiagnosed as having idiopathic developmental delay, attention deficit/hyperactivity disorder and/or autism spectrum disorders, putting them at risk for unnecessary testing and treatments. Conclusion: Children with developmental or speech delay, especially those with a characteristic somatic feature or behavioural abnormalities, should be screened for MPS III. PMID:23336697

Wijburg, Frits A; Wegrzyn, Grzegorz; Burton, Barbara K; Tylki-Szymanska, Anna

2013-01-01

427

Femoral Nerve Palsy due to Anticoagulant Induced Retroperitoneal Hematoma.  

PubMed

A forty-one-year-old man who, sought evaluation for a sudden hip flexion contracture and groin pain with a history of mechanical mitral valve replacement, had been misdiagnosed and treated as having lumbar discopathy for two days. This patient finally was diagnosed with compressive femoral neuropathy due to warfarin-induced retroperitoneal hematoma and successfully managed nonoperatively. This case is reported in order to draw attention to this rare presentation. PMID:25386195

Gurbuz, Orcun; Ercan, Abdulkadir; Kumtepe, Gencehan; Karal, Ilker Hasan; Velioglu, Yusuf; Ener, Serdar

2014-01-01

428

Delivery Induced Intraperitoneal Rupture of a Cystic Ovarian Teratoma and Associated Chronic Chemical Peritonitis  

PubMed Central

Intraperitoneal rupture of cystic ovarian teratoma is a rare complication. We report a case in a 29-year-old female, with increased abdominal circumference 2 months after vaginal delivery. MRI/CT raised this diagnosis associated to chemical peritonitis. A malignant ovarian mass with peritoneal carcinomatosis was excluded. Laparoscopic oophorectomy was performed and histologic analysis confirmed imaging findings. This case demonstrates the interest of imaging before surgery in pelvic masses to avoid misdiagnosing and to provide adequate treatment. PMID:24744942

Nader, Reine; Thubert, Thibault; Deffieux, Xavier; de Laveaucoupet, Jocelyne; Ssi-Yan-Kai, Guillaume

2014-01-01

429

Splenic torsion presenting as a twisted hemorrhagic ovarian cyst.  

PubMed

Torsion of a wandering spleen is rare, usually presenting as an acute abdomen and commonly misdiagnosed. In our case, a 14-year-old girl was diagnosed preoperatively as having a twisted hemorrhagic ovarian cyst. On laparotomy, an infarcted spleen that was twisted on its pedicle was found in the lower abdomen. The patient recovered uneventfully. The clinical spectrum of wandering spleen is discussed briefly. PMID:3880638

Pundaleeka, S K; Zimmers, T E; Nassos, T P

1985-01-01

430

Enduring Fluoride Health Hazard for the Vesuvius Area Population: The Case of AD 79 Herculaneum  

Microsoft Academic Search

BackgroundThe study of ancient skeletal pathologies can be adopted as a key tool in assessing and tracing several diseases from past to present times. Skeletal fluorosis, a chronic metabolic bone and joint disease causing excessive ossification and joint ankylosis, has been only rarely considered in differential diagnoses of palaeopathological lesions. Even today its early stages are misdiagnosed in endemic areas.Methodology\\/Principal

Pierpaolo Petrone; Michele Giordano; Stefano Giustino; Fabio M. Guarino

2011-01-01

431

Ostéomyélite récurrente multifocale chronique de l’enfant :à propos de 17 observations  

Microsoft Academic Search

Chronic recurrent multifocal osteitis (OCRM) is a rare condition in children, of unknown aetiology, which may be misdiagnosed as osteomyelitis, arthritis or tumour.Patients and methods. – We present a retrospective multicentric study of 17 patients (five boys and 12 girls) with an average follow-up of 7.5 years (six months–25 years).Results. – A spectrum of presenting features is possible, ranging from

E Coinde; L David; J Cottalorda; D Allard; M Bost; F Lucht; J. L Stéphan

2001-01-01

432

Cervical thymic cysts  

Microsoft Academic Search

Thymic cysts are rare embryonic remnants along the course of thymic migration in the neck or the anterior mediastinum which\\u000a may result in cervical masses in children, often misdiagnosed. We present the experience gained by three European tertiary\\u000a care medical centers in the treatment of thymic cysts as well as the current data on the embryology, clinical presentation,\\u000a diagnosis and

Bruno Cigliano; Nikolaos Baltogiannis; Marianna De Marco; Elsa Faviou; Dimitrios Antoniou; Ugo De Luca; Michail Soutis; Alesandro Settimi

2007-01-01

433

\\  

Microsoft Academic Search

\\u000a Summary  Swallowing phobia is characterized by difficulty swallowing solid food, liquids or pills, accompanied by intense anxiety,\\u000a restricted eating behaviour and sometimes secondary weight loss. The occurrence of swallowing phobia is facilitated by the\\u000a presence of pre-existing anxiety disorders and often appears after an episode of choking on food. Swallowing phobia is often\\u000a misdiagnosed as eating disorder. A typical case of

Egon Michael Haberfellner

2008-01-01

434

Invasive pneumococcal infection despite 7-valent conjugated vaccine  

PubMed Central

Despite good cover with 7-valent vaccination, invasive pneumococcal infections may still be misdiagnosed and may lead to lifethreatening situations or death in young children. New serotypes are emerging and, therefore, clinicians must keep a high level of suspicion in young children regardless of their vaccination status. We report three cases of invasive pneumococcal infection due to new serotypes not covered by the 7-valent conjugated vaccine, two of which led children to death. PMID:24765491

Joye, Sebastien; Gao, Anja; Kayemba-Kay’s, Simon; Cotting, Jacques; Perez, Marie-Hélène

2013-01-01

435

Unilocular macrocystic serous cystadenoma of the pancreas--atypical features: a case report.  

PubMed

The authors report and discuss an exceedingly rare case of a unilocular macrocystic serous cystadenomas diagnosed in a 63-year-old female patient, which was preoperatively misdiagnosed as a mucinous cystic neoplasm, due to the atypical magnetic resonance (MR) imaging features shown at presentation and the misleading results obtained through cystic fluid analysis. This manuscript overviews the typical and atypical manifestations of this entity and highlights the advantages, potential limitations and pitfalls of both MR imaging and cystic fluid analysis. PMID:24461471

Leite, Inês; Palmeiro, Marta; Farchione, Alessandra; Matos, Celso; Bali, Maria Antonieta; Demetter, Pieter; Delhaye, Myriam

2014-01-01

436

Help-seeking behaviors for female sexual dysfunction: a cross sectional study from Iran  

Microsoft Academic Search

BACKGROUND: Female sexual dysfunctions (FSD) are prevalent multifactor problems that in general remain misdiagnosed in primary health care. This population-based study investigated help-seeking behaviors among women with FSD in Iran. METHODS: This was a cross sectional study carried out in Kohgilouyeh-Boyer-Ahmad province in Iran. Using quota sampling all sexually active women aged 15 and over registered in primary health care

Mariam Vahdaninia; Ali Montazeri; Azita Goshtasebi

2009-01-01

437

Lime-induced phytophotodermatitis  

PubMed Central

This case describes a scenario of lime-induced phytophotodermatitis. Phytophotodermatitis is a dermatitis caused after the skin is exposed to photosensitizing compounds in plants and then exposed to sunlight. Many common plants including citrus fruits, celery, and wild parsnip contain these photosensitizing compounds which cause phytophotodermatitis. It is important for a physician to be aware of phytophotodermatitis because it may often be misdiagnosed as other skin conditions including fungal infection, cellulitis, allergic contact dermatitis, and even child abuse. PMID:25317269

Hankinson, Andrew; Lloyd, Benjamin; Alweis, Richard

2014-01-01

438

Pulmonary tuberculosis as differential diagnosis of lung cancer  

PubMed Central

Patients with lung cancer are often misdiagnosed as pulmonary tuberculosis leading to delay in the correct diagnosis as well as exposure to inappropriate medication. Several factors are responsible for this situation in developing countries, including lack of awareness, inadequate infrastructure and socio-economic factors. This article outlines the differences between the two diseases as well as features that would make a clinician suspect the right diagnosis early. PMID:24455507

Bhatt, MLB; Kant, Surya; Bhaskar, Ravi

2012-01-01

439

Experimental induction of panic-like symptoms in patients with postural tachycardia syndrome  

Microsoft Academic Search

Patients with postural tachycardia syndrome (POTS) might be misdiagnosed with panic disorder due to shared clinical features.\\u000a The first aim of our study was to investigate the relationship between symptoms of POTS and panic disorder. The second aim\\u000a was to delineate clinical features distinguishing symptoms of POTS from panic disorder. A total of 11 patients with POTS and\\u000a 11 control

Ramesh K. Khurana

2006-01-01

440

Isolated hepatic tuberculosis presenting as cystic-like and tumour-like mass lesions.  

PubMed

Hepatic tuberculosis is a rare manifestation of extra-pulmonary tuberculosis. Hepatic tuberculous lesions are especially mimicking tumour-like mass or cystic lesions in the liver and so can be misdiagnosed with several diseases. Histopathological examination of the specimen is essential in the diagnosis for hepatic tuberculosis. In this report, two cases with hepatic tuberculosis having cystic solid mass and abscess liver lesions are described. PMID:21490832

Parsak, Cem Kaan; Hanta, Ismail; Aslan, Ahmet; Alabaz, Omer

2008-01-01

441

Generalized hair casts due to traction.  

PubMed

Peripilar keratin casts, also called pseudonits or hair casts, are thin, elongated, greyish-white, cylindrical, sleeve-like structures that encircle the hair shaft and can easily be slid along the hair. They may be clinically misdiagnosed as nits. In addition to physical removal, keratolytic lotions or shampoos are helpful. We report an 11-year-old girl with pseudonits. Although it is not a rare condition, underdiagnosis is common. PMID:23909653

Ozuguz, Pinar; Kacar, Seval; Takci, Zennure; Ekiz, Ozlem; Kalkan, Goknur; Bulbul Sen, Bilge

2013-01-01

442

Epulis granulomatosa: extraction sequellae.  

PubMed

Epulis granulomatosa is a post-surgical lesion emanating from an extraction socket. It can be misdiagnosed with lesions of similar appearance, for example, foreign body or pyogenic granulomas, or as a herniation of the maxillary sinus. Based on clinical appearance and microscopic description, granulomas all appear to represent essentially the same lesion. However, pathonomonically, the epulis granulomatosa emanates only from an extraction socket; the other granulomas can be found anywhere in the body. PMID:9693538

Leong, R; Seng, G F

1998-01-01

443

Associations of Clinical Stroke Misclassification (‘Clinical-Imaging Dissociation’) in Acute Ischemic Stroke  

Microsoft Academic Search

Background: Up to 20% of lacunar infarcts are clinically misdiagnosed as cortical infarcts and vice versa. The reasons for this discrepancy are unclear. We assessed clinical and imaging features which might explain this ‘clinical-imaging dissociation’ (C-ID). Methods: Patients with an acute stroke syndrome (cortical or lacunar) underwent magnetic resonance imaging including diffusion-weighted imaging (DWI). We recorded DWI-positive infarcts and proximity

Gillian Potter; Fergus Doubal; Caroline Jackson; Cathie Sudlow; Martin Dennis; Joanna Wardlaw

2010-01-01

444

Chapter 12: Congenital Rubella  

Microsoft Academic Search

Rubella is a viral illness caused by a togavirus of the genus Rubivirus and is characterized by a mild, maculopapular rash. The rubella rash occurs in 50% to 80% of rubella-infected persons and is sometimes misdiagnosed as measles or scarlet fever. Children usually develop few or no constitutional symptoms, but adults may experience a 1-5 day prodrome of low-grade fever,

Syndrome Laura Zimmerman; Susan Reef

445

Self-medication for infants with colic in Lagos, Nigeria  

Microsoft Academic Search

BACKGROUND: Infantile colic is a self-limiting condition that is distributed worldwide. It is often misdiagnosed as an organic disease for which an infant is admitted to the hospital. Many studies have described the aetiopathogenesis, pharmacologic and non-pharmacologic management of colic but none has evaluated self-medication for infants with colic. The aim of this study was therefore to determine the knowledge

Kazeem A Oshikoya; Idowu O Senbanjo; Olisamedua F Njokanma

2009-01-01

446

Spinal Epidural Arteriovenous Hemangioma Mimicking Lumbar Disc Herniation  

PubMed Central

A spinal epidural hemangioma is rare. In this case, a 51 year-old female patient had low back pain and right thigh numbness. She was initially misdiagnosed as having a ruptured disc with possible sequestration of granulation tissue formation due to the limited number of spinal epidural hemangiomas and little-known radiological findings. Because there are no effective diagnostic tools to verify the hemangioma, more effort should be put into preoperative imaging tests to avoid misdiagnosis and poor decisions). PMID:23133733

Kim, Kyung Hyun; Song, Sang Woo; Lee, Soo Eon

2012-01-01

447

Surgical treatment of thoracic outlet syndrome in young adults: single centre experience with minimum three-year follow-up  

Microsoft Academic Search

Thoracic outlet syndrome is an often misdiagnosed syndrome which consists of a neurovascular compression at the upper thoracic\\u000a outlet. The clinical presentation can be variable, ranging from mild symptoms to venous thrombosis and muscle atrophy. Many\\u000a aetiologies, both congenital and acquired, related either to bony or soft tissue anomalies, have been associated with this\\u000a syndrome. As a consequence, the diagnosis

Pietro Ciampi; Celeste Scotti; Simonetta Gerevini; Francesco De Cobelli; Roberto Chiesa; Gianfranco Fraschini; Giuseppe M. Peretti

448

[Localized amyloidosis of the seminal vesicles].  

PubMed

Amyloidosis of the seminal vesicles is a common finding in autopsies, with increased incidence in older population. It is usually asymptomatic. We report a case of symptomatic localized amyloidosis of the seminal vesicles, with hemospermia and suprapubic pain. Diagnosis was achieved through ultrasound-guided transrectal biopsy. Systemic amyloidosis must be ruled out through proper evaluation. Seminal vesicle enlargement secondary to amyloid deposit may be misdiagnosed as carcinomatous invasion. PMID:14735867

Herranz Fernández, L M; Arellano Gañán, R; Nam Cha, Syonghyun; Jiménez Gálvez, M; Pereira Sanz, I

2003-01-01

449

A case report of concomitant paroxysmal nocturnal hemoglobinuria and heterozygous ?-thalassemia  

Microsoft Academic Search

Paroxysmal nocturnal hemoglobinuria (PNH) is a rare clonal blood disorder that presents chronic intravascular hemolysis. PNH\\u000a concomitant with inherited hemolytic anemia has been rarely reported. Here, we report an interesting PNH patient who was misdiagnosed\\u000a with iron deficiency anemia due to concomitant heterozygous ?-thalassemia. The patient experienced dizziness, fatigue, and\\u000a restricted physical activity for the previous 3 years. Thalassemia gene analysis

Xiao-Lin Yin; Tian-Hong Zhou; Lin Peng; Xin-Hua Zhang; Li Wang; Ya-Li Zhou; Yong-Sheng Chen; Yuan-Yuan He

2011-01-01

450

Case for diagnosis.  

PubMed

We report a clinical case of a rare variant of pemphigus - pemphigus herpetiformis - which combines the clinical features of dermatitis herpetiformis with the immunological findings of pemphigus. Due to its atypical presentation, it is frequently misdiagnosed as dermatitis herpetiformis. It is basically characterized by the herpetiform pattern of skin lesions, severe pruritus and by the presence of eosinophilic spongiosis confirmed on histopathology. We call attention to the excellent response to dapsone. PMID:23197221

Fernandes, Iolanda Conde; Sanches, Madalena; Alves, Rosário; Selores, Manuela

2012-01-01

451

Autism spectrum disorders in the DSM-V: Better or worse than the DSM-IV?  

Microsoft Academic Search

The DSM-V-committee has recently published proposed diagnostic criteria for autism spectrum disorders. We examine these criteria in some detail. We believe that the DSM-committee has overlooked a number of important issues, including social imagination, diagnosis in infancy and adulthood, and the possibility that girls and women with autism may continue to go unrecognised or misdiagnosed under the new manual. We

Lorna Wing; Judith Gould; Christopher Gillberg

2011-01-01

452

Diagnosis and treatment of intraoperative popliteus tendon impingement.  

PubMed

Herein, we describe a simple, effective strategy for diagnosing and treating intraoperative popliteus tendon impingement during total knee arthroplasty (TKA). When lateral impingement is detected intraoperatively during TKA, manual isolation of the popliteus tendon can help determine the cause. Using this technique, the etiology of intraoperative lateral impingement during TKA was never misdiagnosed and the popliteus tendon was never unnecessarily released. The technique described allows for accurate diagnosis of intraoperative lateral impingement during TKA and the prevention of unnecessary popliteus resection. PMID:24474167

Kazakin, Anatoly; Nandi, Sumon; Bono, James

2014-12-01

453

Isolated sphenoidal sinusitis in children  

Microsoft Academic Search

Acute isolated infectious sphenoiditis is an uncommon, potentially dangerous condition which is often misdiagnosed because\\u000a of its nonspecific symptoms and paucity of clinical signs. We present eight children with isolated sphenoiditis who were managed\\u000a in our medical centre during the last 2 years and review the literature. All the patients were adolescents or pre-adolescents\\u000a and all experienced moderate to severe

Y. Haimi-Cohen; J. Amir; A. Zeharia; Y. Danziger; N. Ziv; M. Mimouni

1999-01-01

454

Hair casts  

PubMed Central

Hair casts or pseudonits are circumferential concretions, which cover the hair shaft in such a way that, it could be easily removed. They are thin, cylindrical, and elongated in length. We present an unusual case of an 8-year-old girl presenting with hair casts. Occurrence of these is unusual, and they may have varied associations. This patient was suffering from developmental delay. It is commonly misdiagnosed as and very important to differentiate from pediculosis capitis.

Parmar, Sweta S.; Parmar, Kirti S.; Shah, Bela J.

2014-01-01

455

Hair casts.  

PubMed

Hair casts or pseudonits are circumferential concretions, which cover the hair shaft in such a way that, it could be easily removed. They are thin, cylindrical, and elongated in length. We present an unusual case of an 8-year-old girl presenting with hair casts. Occurrence of these is unusual, and they may have varied associations. This patient was suffering from developmental delay. It is commonly misdiagnosed as and very important to differentiate from pediculosis capitis. PMID:25396168

Parmar, Sweta S; Parmar, Kirti S; Shah, Bela J

2014-10-01

456

[Anti-fungal resistant hypopigmented macules in an adolescent].  

PubMed

Progressive macular hypomelanosis of the trunk is a disease of unknown origin that often goes unrecognized in the clinical setting. We present an adolescent with this condition initially diagnosed as tinea versicolor. She was asymptomatic, with hypopigmented macules located on the trunk and with no previous history of inflammation, infection or injury. Progressive macular hypomelanosis is a common disorder that has frequently been misdiagnosed, probably because it is often considered a post-inflammatory hypopigmentation or pityriasis versicolor. PMID:22935838

Martínez Martínez, M L; Azaña Defez, J M; López Villaescusa, M T; Gómez Sánchez, M

2012-09-01

457

Schizoaffective Disorder With Missed Diagnosis of Acute Porphyria: A Case Report and Overview  

PubMed Central

Acute porphyrias are often misdiagnosed and most commonly present as atypical neuropsychiatric symptoms or acute abdominal pain. Clinicians should suspect acute porphyrias in patients presenting with variable neuropsychiatric symptoms and unexplained pain. Proper identification can lead to less iatrogenicity associated with porphyrinogenic agents, appropriate management, and a better patient outcome. The case of a patient with hereditary coproporphyria, one of the acute porphyrias, is presented to illustrate the broad manifestations, unsuspected diagnosis, and difficulties in management. PMID:22454794

Bennett, Jeffrey I.; Resch, David S.; Godwin, John E.

2011-01-01

458

Femoral Nerve Palsy due to Anticoagulant Induced Retroperitoneal Hematoma  

PubMed Central

A forty-one-year-old man who, sought evaluation for a sudden hip flexion contracture and groin pain with a history of mechanical mitral valve replacement, had been misdiagnosed and treated as having lumbar discopathy for two days. This patient finally was diagnosed with compressive femoral neuropathy due to warfarin-induced retroperitoneal hematoma and successfully managed nonoperatively. This case is reported in order to draw attention to this rare presentation. PMID:25386195

Gurbuz, Orcun; Ercan, Abdulkadir; Kumtepe, Gencehan; Karal, Ilker Hasan; Velioglu, Yusuf; Ener, Serdar

2014-01-01

459

Ruptured cardiac angiosarcoma with pulmonary metastases: A rare disease with a common (mis)diagnosis!  

PubMed Central

In Indian settings pulmonary tuberculosis remains the most common diagnosis in a patient presenting with constitutional symptoms, hemoptysis and lung opacities. We describe a case report of a fifty-year-old woman who was receiving empirical anti-tubercular drugs for a metastatic illness to lungs arising from a primary angiosarcoma in the right atrium. This rare entity was misdiagnosed and typical echocardiographic findings suggested this diagnosis. PMID:23253417

jain, Gagan; Mukhopadhyay, Saibal; kurien, Sumod; Yusuf, Jamal; tyagi, Sanjay; jain, Rajat

2012-01-01

460

Ruptured cardiac angiosarcoma with pulmonary metastases: a rare disease with a common (mis)diagnosis!  

PubMed

In Indian settings pulmonary tuberculosis remains the most common diagnosis in a patient presenting with constitutional symptoms, hemoptysis and lung opacities. We describe a case report of a fifty-year-old woman who was receiving empirical anti-tubercular drugs for a metastatic illness to lungs arising from a primary angiosarcoma in the right atrium. This rare entity was misdiagnosed and typical echocardiographic findings suggested this diagnosis. PMID:23253417

Jain, Gagan; Mukhopadhyay, Saibal; Kurien, Sumod; Yusuf, Jamal; Tyagi, Sanjay; Jain, Rajat

2012-01-01

461

Evaluation of Three Techniques for Detection of Low-Level Methicillin-Resistant Staphylococcus aureus (MRSA): a Disk Diffusion Method with Cefoxitin and Moxalactam, the Vitek 2 System, and the MRSA-Screen Latex Agglutination Test  

Microsoft Academic Search

Very-low-level methicillin-resistant Staphylococcus aureus (MRSA), or class 1 MRSA, is often misdiagnosed as methicillin-susceptible S. aureus (MSSA). We evaluated the performances of three methods for detection of low-level methicillin resistance: the disk diffusion method using the cephamycin antibiotics cefoxitin and moxalactam, the Vitek 2 system (bioMerieux), and the MRSA-screen test (Denka). Detection of the mecA gene by PCR was considered

Annie Felten; Bernadette Grandry; Philippe Henri Lagrange; Isabelle Casin

2002-01-01

462

Diabetic Muscle Infraction: An Unusual Cause of Muscle Pain in a Diabetic Patient on Hemodialysis  

Microsoft Academic Search

Diabetic muscle infarction (DMI) is a rare, painful and potentially serious complication in patients with poorly controlled diabetes mellitus and frequently misdiagnosed clinically as abscess, neoplasm, or myositis. A 36-year-old diabetic woman referred to our clinic with severe pain in the left antero-medial thigh. She had a 15-year history of Type 2 diabetes mellitus (DM). She was complicated by diabetic

Ibrahim Sahin; Cagatay Taskapan; Hulya Taskapan; Tamer Baysal; Recep Bentli; Selda Tekes; Feridun Kosar; Iclal Gurses

2005-01-01

463

Clinical and pathologic factors associated with delayed diagnosis in solitary rectal ulcer syndrome  

Microsoft Academic Search

Solitary rectal ulcer syndrome (SRUS) often goes unrecognized or is misdiagnosed. Of 98 patients with a final clinicopathologic diagnosis of SRUS, an initially incorrect diagnosis had been made in 25 patients (26 percent). In these 25 patients with a misdiagnosis, the median age was 43 years and the female-to-male ratio was 3.2?1. The median duration of incorrect diagnosis was five

Joe J. Tjandra; Victor W. Fazio; Robert E. Petras; Ian C. Lavery; John R. Oakley; Jeffrey W. Milsom; James M. Church

1993-01-01

464

Lethal nature of ischemic gastropathy: a case report of celiomesenteric vascular insufficiency  

Microsoft Academic Search

Celiomesenteric ischemia has an insidious onset and the non-specific symptoms are often misdiagnosed as cholecystitis or peptic\\u000a ulcer disease with a consequential delay between the onset of symptoms and radiological evidence of vascular occlusive disease.\\u000a A elderly man was hospitalized after a 2–3 week history of acute abdominal pain, frequent vomiting, and chronic diarrhea associated\\u000a with bloody stools. Upper gastrointestinal endoscopy

Luca De Luca; Luigi Ricciardiello; Pietro Modugno; Carlo Maria De Filippo; Danilo Baroncini

2011-01-01

465

Anterior cruciate ligament mucoid degeneration: a review of the literature and management guidelines  

Microsoft Academic Search

Purpose  Anterior cruciate ligament (ACL) mucoid degeneration is a rare encounter in clinical practice, different, but often confused\\u000a with ACL mucoid cysts. Its pathophysiology remains unclear. However, recent publications have suggested that it might be underdiagnosed\\u000a or misdiagnosed, and that the adverse effects of treatment by ACL resection might be underestimated. The object of this work\\u000a was to summarize this scattered

Francois Lintz; Nicolas Pujol; Philippe Boisrenoult; Kevin Bargoin; Philippe Beaufils; David Dejour

2011-01-01

466

An atypical presentation of testicular torsion: a case report.  

PubMed

Testicular torsion is an emergent condition requiring prompt surgical intervention to avoid permanent testicular compromise and death. As its symptoms overlap with other disease processes, diagnosis is sometimes difficult. When considering the presenting symptoms, one must be careful not to ignore unusual causes of torsion and misdiagnose the patient. In this case report we describe an unusual etiology of testicular torsion (traumatic) with an atypical patient presentation (mildly painful) which presented many obstacles before proper diagnosis and treatment. PMID:24294708

Jansen, Robert; Fooks, Henry; Zaslau, Stanley

2013-01-01

467

Vulvodynia: case report and review of literature.  

PubMed

Vulvodynia is defined as chronic vulvar burning, stinging, rawness, soreness or pain in the absence of objective clinical or laboratory findings to explain these symptoms. Vulvodynia is a chronic pain syndrome affecting up to 18% of the female population and is generally regarded as an underdiagnosed difficult to treat gynecological disorder. An increasing number of patients present with symptoms of vulvar pain, soreness, burning or irritation, which becomes chronic. Vulvodynia is a term used to describe chronic burning and/or pain in the vulva without objective clinical or laboratory findings to explain these symptoms. We present a case of vulvodynia accompanying somatoform disorder and depression. PMID:17998784

Gumus, Ilknur Inegol; Sarifakioglu, Evren; Uslu, Hilal; Turhan, Nilgun Ozturk

2008-01-01

468

Clinical effect of Kukkutanda Twak Bhasma in the management of Swetapradara  

PubMed Central

Swetapradara is an important gynecological disorder nowadays. Most women in the reproductive age group complain about white discharge. Due to white discharge, they are prone to so many other symptoms, such as backache, itching in vulva, and burning micturition. According to Ayurveda, swetapradara is caused by the vitiation of Kapha and Vata dosha. Kukkutanda twak is also said to be Kapha Vata shamaka and swetapradara shamaka. In Ayurveda so many drugs are mentioned in the treatment of swetapradara. Among them Kukkutanda twak bhasma is a good medicine. In this clinical study Kukkutanda twak bhasma has shown statistically significant improvement in white discharge, backache, itching, anemia, weakness, and urinary tract infection. PMID:22529653

Panda, Gatikrushna; Mohapatra, K. B.

2011-01-01

469

Cercopithifilaria leporinus n. sp. (Nematoda: Filarioidea) from the snowshoe hare (Lepus americanus Erxleben) (Lagomorpha) in Canada.  

PubMed

Cercopithifilaria leporinus n. sp. from the subcutaneous tissues of the trunk of snowshoe hares (Lepus americanus Erxleben) in Ontario and Alberta, Canada, is described. This is the only species of Dipetalonema--like filarioid known from lagomorphs. It is distinguished from other species of Cercopithifilaria by its small size, numerous mucrons on the female tail, vulva leading into a large, spherical vestibule and the pattern of papillae on the male tail. Eight species of filarioids, representing four genera, are now known from lagomorphs. Dirofilaria timidi Gubanov and Fedorov, 1966 is considered as a species inquirenda. PMID:6614747

Bartlett, C M

1983-01-01

470

Squamous cell peritonitis associated with hydrometrocolpos in a multimalformed newborn.  

PubMed

We present the case of a 1 day-old newborn with extensive squamous cell peritonitis resulting from vaginal atresia with hydrometrocolpos and squamous cell reflux through the genital system, a combination rarely recognized in the literature. Delivery was preceded by ultrasound diagnosis of oligohydramnios and "large bladder," the latter representing the dilated proximal vagina. Additional findings included paraesophageal hiatus hernia containing squames, urethral atresia, absence of vulva, lung hypoplasia, mild hypoplasia of the corpus callosum, and short umbilical cord with single umbilical artery (SUA). The possible relationship of the SUA with the constellation of infradiaphragmatic malformations is discussed. PMID:16338878

Drut, Ricardo

2005-01-01

471

[Selected vulvar dermatoses].  

PubMed

Numerous cutaneous lesions are located in the region of the female genital organs, occasionally presenting a diagnostic and therapeutic challenge. The most common cases include: eczema vulvae, lichen simplex chronius, lichen sclerosus et atrophicus or lichen planus. Clinical presentation of these lesions is not always characteristic for certain dermatoses. Thus, it is important to conduct proper tests, including histopathological or contact allergy examination. Only thorough diagnostics allows to implement correct therapy. This paper shows a detailed description of dermal lesions located in the region of the female genital organs of the allergic and lichenoid origin, together with the literature review on diagnosis and treatment. PMID:24455854

Olek-Hrab, Karolina; Jenerowicz, Dorota; Osmola-Ma?kowska, Agnieszka; Pola?ska, Adriana; Teresiak-Miko?ajczak, Ewa; Silny, Wojciech; Adamski, Zygmunt

2013-11-01

472

Extramammary Paget's disease of scrotum treated with radiotherapy.  

PubMed

Extramammary Paget's disease (EMPD) of the scrotum is extremely rare. Most cases are found on the vulva or anus. It is generally accepted that EMPD is associated with an underlying carcinoma in situ. The lesion is located deep in between the dermal to epidermal layer. EMPD must be differentiated from benign papulosquamous disease, squamous cell carcinoma and melanoma. It can be managed by local excision and reconstruction with a skin graft or skin flap. Radiation and topical chemotherapy have also been used as alternative treatment strategies and are effective for local control. PMID:19476986

Kim, Tae Heung; Chang, In Ho; Kim, Tae-Hyoung; Lee, Shin Young; Myung, Soon Chul

2009-08-01

473

Vulvar Langerhans cell histiocytosis: a case report  

PubMed Central

Langerhans cell histiocytoses (LCH) are a rare group of disorders that comprise a large spectrum of diseases initially known as histiocytosis X. In this case report, we relate a case of LCH affecting the vulva of a 47-year-old female. The patient presented since 3 years with a vulvar lesion characterized by non-healing ulcers and a perineal granuloma on which she underwent surgery. Professionals should keep in mind not to treat straightforwardly lesions of the genital tract as simple sexually transmitted diseases. Chronic, atypical genital lesions seen in women need to be worked up and dealt with accordingly.

Khoummane, Nadia; Guimeya, Cyriane; Lipombi, Dominique; Gielen, Francois

2014-01-01

474

Aggressive Angiomyxoma with Perineal Herniation  

PubMed Central

Aggressive angiomyxoma is a rare mesenchymal tumor involving the pelvic-perineal region. It occurs during the third and fourth decade of life and is predominantly seen in females. It presents clinically as a soft tissue mass in variable locations such as vulva, perianal region, buttock, or pelvis. Assessment of extent of the tumor by radiological evaluation is crucial for surgical planning; however, biopsy is essential to establish diagnosis. We present the radiological and pathological features seen in a 43-year-old female diagnosed with abdominal angiomyxoma with an unusual extension to the perineum. PMID:24987570

Narang, Seema; Kohli, Supreethi; Kumar, Vinod; Chandoke, Raj

2014-01-01

475

Resection and Reconstruction of Maxillary Class IIIc Defect in a Case of Adenoid Cystic Carcinoma: Cost-Sensitive Technique without Microvascular Grafts.  

PubMed

ACC is a rare malignant tumor that affects most commonly the major and minor salivary glands and rarely the paranasal sinuses, lacrimal gland, larynx, ear, vulva, and so forth. The maxillary sinus when affected is considered having a poor prognosis due to delayed diagnosis and delayed treatment credited to its slow spread, late symptoms, and complex anatomy which hampers surgical resection. The expressions of tumor markers too have a significant role in determining the prognosis. The treatment of choice consists of wide radical resection of the tumor followed by radiotherapy. Rehabilitation options in cases with huge maxillary defects still need further exploration. PMID:24069539

Adwani, Dwarkadas; Bhattacharya, Anirudh; Arora, Rajender Singh; Soni, Ramawatar; Adwani, Nitin

2013-01-01

476

New Pudicinae (Trichostrongylina, Heligmosomoidea), Pudica ctenomydis n. sp. parasite of Ctenomys talarum (Rodentia: Octodontidae) from Argentina.  

PubMed

A total of 138 nematodes were found in the small intestine of Ctenomys talarum (Octodontidae) from Mar de Cobo, Argentina. A new nematode species, Pudica ctenomydis n. sp., is described. The new species more closely resembles P. pujoli Durette-Desset, 1990, parasite of Microcavia niata Thomas, from Bolivia. It can be distinguished from P. pujoli by the number of ridges and characteristics of the synlophe, the spicular morphology, differences in length between rays 9 and 10, and by the presence of a symmetrical caudal bursa and a cuticular expansion surrounding the body between vulva and anus in females. PMID:16378752

Rossin, M A; Timi, J T; Malizia, A I

2006-03-01

477

Recognizing and Handling Calving Problems.  

E-print Network

through the vagina and reaches the vulva intact. It may protrude as a water bag fil/ed with dark amber fluid. Occasion ally the membrane breaks before it becomes visible. Then it is observed simply as a sudden and large expulsion of straw.... This situation can be caused by twisting of the uterus or rotation of the calf. Never attempt delivery in this position. Professional assis tance often is required. Figure 14. An alternate means of correcting a head and neck deviation in an anterior...

Beverly, John R.

1979-01-01

478

Hysteroscopy and episiotomy in a rescued, cold-stressed Florida manatee (Trichechus manatus latirostris) for diagnosis and treatment of a retained fetal skeleton.  

PubMed

A rescued female manatee was observed expelling a fetal bone from the vulva. The manatee was anesthetized and diagnosed with uterine retention of a fetal skeleton by ultrasound and hysteroscopy. Episiotomy was performed to gain manual access to the vagina and uterus for removal of the skeleton. Second intention healing of the episiotomy site produced excellent results. Rescued female manatees should receive a thorough reproductive tract evaluation since presence of retained fetal tissues might not be evident in blood or hormone analyses. Retention of a whole or partial dead fetus can be life-threatening to manatees, and retained tissues should be removed as early as possible. PMID:23082540

Hall, Natalie H; Walsh, Mike; DeLuca, Catherine; Bukoski, Alex

2012-09-01

479

Diagnostic accuracy in patients admitted to hospitals with cellulitis.  

PubMed

Misdiagnosis of non-infectious conditions such as cellulitis is a common error and can result in unnecessary hospitalization and antibiotic use. We sought to prospectively determine the misdiagnosis rate of cellulitis among hospitalized patients and to determine if a visually-based computerized diagnostic decision support system (VCDDSS, also named VisualDx) could generate an improved differential diagnosis (DDx) for misdiagnosed patients. In two separate institutions, attending dermatologists or infectious disease specialists evaluated all consecutive patients hospitalized for "cellulitis" by the emergency department. Among 145 subjects enrolled, misdiagnosis occurred in 41 (28%) patients. The diagnosis most commonly mistaken as cellulitis was stasis dermatitis (37%). At one center, in cases that were misdiagnosed by the emergency department, the VCDDSS included the correct diagnosis in the DDx more frequently than the admitting team (18/28 cases (64%) compared to 4/28 cases (14%), p=0.0003). These results demonstrate the capability of this VCDDSS to assist primary care physicians with generating a more accurate DDx when confronted with patients presenting with possible skin infections. Misdiagnoses may result in a significant source of healthcare costs and misdiagnosis-related patient harm. Inclusion of decision support tools early in the diagnostic workflow may reduce misdiagnosis and result in more efficient healthcare management. PMID:21426867

David, Consuelo V; Chira, Sandy; Eells, Samantha J; Ladrigan, Manasi; Papier, Art; Miller, Loren G; Craft, Noah

2011-01-01

480

Vulval intestinal/enteric heterotopia with a 10-yr follow-up: a case report and review of the literature.  

PubMed

The occurrence of ectopic intestinal/enteric-type epithelium at the vulva is a rare entity sometimes mimicking intraepithelial neoplasia or malignant disease. Here, we report a case of an 82-yr-old woman with a long-standing (10 yr) white papillary lesion with some reddish areas at her left labium, extending into the vaginal introitus. Biopsy reports revealed colonic-type glandular epithelium with positive immunostaining against CDX-2, p53, CK 7, and CEA, whereas staining against estrogen and progesterone receptor, mammoglobin, GCDFP-15, and CK 20 was reported to be negative. A follow-up of 10 yr appeared uneventful. The occurrence of celomic-type glandular epithelium at the vulva may represent the result of dysontogenetic replacement of embryonic stem cells, which undergo mucinous differentiation. Thus, the proper diagnostic term may be glandular heterotopia. Although some lesions, especially in the proximity to orthotopic vulval glands, may be of metaplastic origin. Immunohistochemical staining patterns (CEA, CK 7 positive, and CK 20 negative) indicate an intestinal/enteric phenotype (i.e. intestinal/enteric heterotopia). Because of the reported increased risk of malignant transformation of glandular vulval lesions, close clinical follow-up is recommended. PMID:24681736

Horn, Lars-Christian; Bauerfeind, Ursula Katharina; Strau, Hans-Georg; Karbe, Ina

2014-05-01

481

Photosensitization in sheep fed Ammi majus (Bishop's weed) seed.  

PubMed

Ammi majus (bishop's weed) grows on the coastal region of southern United States and in other parts of the world. This plant causes severe photosensitization in livestock and probably contributes to the severe photosensitization outbreaks seen in Texas. Sheep were fed finely ground seed of A majus via stomach tube at dose rates of 1, 2, 4, and 8 g/kg of body weight and exposed to sunlight. The single dose of 8 g/kg produced severe clinical signs (in 24 to 48 hours): cloudy cornea, conjunctivokeratitis, photophobia, and edema of the muzzle, ears, and vulva. Daily dosing at 2 and 4 g/kg produced (in 72 to 96 hours) similar signs, whereas the smallest dose (1 g/kg) produced mild irritation of the muzzle. Pathologic changes included (1) corneal edema and marked neutrophilic infiltration of the cornea and corneal/ciliary process, (2) subacute ulcerative and exudative dermatitis of the skin of ears, muzzle, and vulva, and (3) mild focal tubular degeneration (vacuolar type) of the kidney. PMID:564651

Witzel, D A; Dollahite, J W; Jones, L P

1978-02-01

482

New species of Spauligodon Skrjabin, Schikhobalova & Lagodovskaja, 1960 and Thubunea Seurat, 1914 (Nematoda) from the gastro-intestinal tract of lizards in Iran.  

PubMed

As part of a faunistic study on helminth parasites of Iranian lizards collected from localities in the north of Isfahan province in Iran, two new nematode species belonging to two different families, Pharyngodonidae Travassos, 1919 and Physalopteroidae Railliet, 1893, were found and are, hereby, described. Spauligodon persiensis n. sp. from the large intestine of Cyrtopodion scabrum Heyden is characterised by its imperceptible lateral alae, lack of spicule, different shape of the genital curtain, position of last pair of papillae, aspinose tail in males, position of the vulva and excretory pore, and a tail filament with six to nine spines in females. Thubunea mobedii n. sp. from the stomach of Laudakia nupta nupta (De Filipi) differs from the other species in the genus by possessing a vulva at level of the posterior portion of the oesophageal-intestinal junction in females, lacking spicules, and having a different number of papillae in males. The present paper provides the results of detailed morphological examination of the two new nematode species, using both light and scanning electron microscopy. Taxonomically important characteristics for the members of the two nematode genera, Spauligodon Skrjabin, Schikhobalova & Lagodovskaja, 1960 and Thubunea Seurat, 1914, are also reviewed. PMID:25301515

Pazoki, Samaneh; Rahimian, Hassan

2014-11-01

483

Cryphodera sinensis n. sp. (Nematoda: Heteroderidae), a non-cyst-forming parasitic nematode from the root of ramie Boehmeria nivea in China.  

PubMed

Cryphodera sinensis n. sp. is described from ramie (Boehmeria nivea) based on the morphology and molecular analyses of rRNA small subunit (SSU), D2D3 expansion domains of large subunit (LSU D2D3) and internal transcribed spacer (ITS). This new species is characterized by oval females with a distinct subcrystalline layer and pronounced and protruding vulval lip, distinctly concave vulva-anus profile and a vulva-anus distance of 29.5-35.8 ?m. Males possess two annuli in the lip region, a stylet 27-32.5 ?m in length with round knobs sloping slightly posteriorly, lateral fields with three lines, spicules 20-28 ?m long and the presence of a short cloacal tube. Second-stage juveniles possess three lip annuli, a stylet 28-31 ?m in length with well-developed knobs projected anteriorly and three lines along the lateral field. The pointed tail, 52-65 ?m long, possesses a mucro-like tip and a hyaline region, 24.5-35 ?m long. Large phasmids with a lens-like structure are located 2-6 annuli posterior to the anus. Phylogenetic analysis shows that the species has unique SSU, LSU D2D3 and ITS rRNA sequences. Phylogenetic relationships of the three rDNA sequences of C. sinensis n. sp. and other cystoid/cyst nematodes are analysed together with a comparison of other species within the genus Cryphodera. PMID:23782683

Zhuo, K; Wang, H H; Ye, W; Peng, D L; Liao, J L

2014-12-01

484

Changes to cuticle surface ultrastructure and some biological functions in the nematode Caenorhabditis elegans exposed to excessive copper.  

PubMed

Copper is an essential metal, but its toxic effects are pronounced when organisms are exposed to it in excessive amounts. However, information about the effects of chronic copper exposure on the cuticle ultrastructure of organisms is insufficient. Studies of the model organism, Caenorhabditis elegans, could further our understanding of the effect of chronic excessive copper exposure on human health. In this study, the cuticle surface ultrastructure of C. elegans was observed using scanning electron microscopy after excessive copper exposure. In addition to this, some biological functions, such as chemotaxis, reproduction, and development, were also analyzed. After chronic excessive copper exposure, the worms' body surface from vulva to tail was extensively wrinkled and folded along with the annulus. The worm's vulva size was significantly decreased, and the middle ridge of the alae was disrupted. Furthermore, some of the biological functions of nematodes were also affected: the chemotaxis index was partially changed, bags-of-worms were induced, development was delayed, and egg-laying number was decreased by copper treatment. The results of the present study shed new light on the effects of copper on C. elegans cuticle as well as some biological functions. PMID:24468967

Song, Shaojuan; Guo, Yaping; Zhang, Xiaomin; Zhang, Xueyao; Zhang, Jianzhen; Ma, Enbo

2014-04-01

485

Early invasive vulvar squamous cell carcinoma arising in a woman with vulvar pemphigus vulgaris and systemic lupus erythematosus  

PubMed Central

Background Pemphigus vulgaris (PV) is an autoimmune blistering disease of the skin and mucous membranes. Genital involvement occurs when most other common sites are concurrently affected or are in remission. Systemic lupus erythematosus (SLE) is an autoimmune disease that may affect many parts of the body and the skin with occasional bullous lesions. Pemphigus vulgaris and SLE may be associated, albeit rarely. Here, we report the first case of a woman affected with SLE presenting with early invasive squamous cell carcinoma (SCC) arising from Pemphigus Vulgaris of the vulva. Case presentation A 27-year-old Caucasian woman was admitted to our Gynaecology Unit for bleeding vegetant lesions of the vulva. Her history was characterized by systemic lupus erythematosus and PV. Biopsy showed concomitant PV and vulvar intraepithelial neoplasia (VIN) grade 3. One month later a new biopsy revealed progression from VIN 3 to early SCC. Despite chemotherapy, no remission of disease was observed. She died six months after diagnosis Conclusion Our case underlines PV as another chronic inflammatory disease of the lower genital tract predisposing to VIN-SCC. It suggests the need for careful follow-up of patients with chronic inflammatory disease, especially when concomitant autoimmune disorders are present. Moreover, a biopsy should be always performed if there are PV lesions because of the possibility of neoplastic disease. PMID:20573220

2010-01-01

486

Augmented Central Pain Processing in Vulvodynia  

PubMed Central

Vulvodynia (VVD) is a chronic pain disorder, wherein women display sensitivity to evoked stimuli at the vulva and/or spontaneous vulvar pain. Our previous work suggests generalized hyperalgesia in this population, however little is known about central neurobiological factors that may influence pain in VVD. Here we investigated local (vulvar) and remote (thumb) pressure evoked pain processing in 24 VVD patients compared to 13 age-matched, pain-free healthy controls (HC). As a positive control we also examined thumb pressure pain in 24 fibromyalgia (FM) patients. The VVD and FM patients displayed overlapping insular brain activations that were greater than HC, in response to thumb stimulation (P<0.005 corrected). Compared to HC, VVD participants displayed greater levels of activation during thumb stimulation within the insula, dorsal mid-cingulate, posterior cingulate and thalamus (P<0.005 corrected). Significant differences between VVD subgroups (primary versus secondary and provoked versus unprovoked) were seen within the posterior cingulate with thumb stimulation, and within the precuneus region with vulvar stimulation (provoked versus unprovoked only). The augmented brain activation in VVD patients in response to a stimulus remote from the vulva suggests central neural pathology in this disorder. Moreover, differing central activity between VVD subgroups suggests heterogeneous pathologies within this diagnosis. PMID:23578957

Hampson, Johnson P.; Reed, Barbara D.; Clauw, Daniel J.; Bhavsar, Rupal; Gracely, Richard H.; Haefner, Hope K.; Harris, Richard E.

2013-01-01

487

Methods of estrus detection and correlates of the reproductive cycle in the sun bear (Helarctos malayanus).  

PubMed

The objective was to explore multiple methods for detecting and characterizing the reproductive cycle of the sun bear (Helarctos malayanus). Thirteen H. m. euryspilus females, loaned from the Malaysian government to US zoos, were used. Fecal metabolite concentrations of estrogen and progesterone were compared to vaginal cytology, changes in genital appearance, and behavior (videotapes and zookeeper observations). Cytology and video behavior were characterized during five hormonally defined states: high, low, and baseline progesterone, estrus, and high estrogen. Among states, there were significant differences in cytology and behavior. Sexual, affiliative, and stereotypic behaviors were highest during estrus, whereas affiliative and social behaviors were lowest during high progesterone. In this captive breeding population, 30.8% of females cycled two or three times a year, 30.8% cycled once a year, and 38.5% did not cycle during this study. Inter-estrus intervals were (mean ± SEM) 115.7 ± 6.3 d (range, 101-131). Spearman rank correlations were significant between both ordinal sexual and affiliative behaviors and vulva swelling and color. Sexual behavior was significantly positively correlated with superficial and keratinized cells, but negatively correlated with parabasal and basophilic cells in cycling females (opposite pattern for appetitive behavior). In conclusion, data for cytology, vulva changes and behavior were consistent with, and complementary to, hormonal data; collectively, they delineated estrus and identified specific reproductive types. PMID:20688366

Frederick, Cheryl; Kyes, Randall; Hunt, Kathleen; Collins, Darin; Durrant, Barbara; Wasser, Samuel K

2010-10-15

488

Calcaridorylaimus castaneae sp. n. (Nematoda, Dorylaimidae) from Bulgaria with an identification key to the species of the genus.  

PubMed

An unknown species belonging to the genusCalcaridorylaimus Andrássy, 1986 was collected from the litter of broadleaf forests dominated by Castanea sativa Mill. and mixed with Quercus daleshampii Ten. and Fagus sylvatica L. on Belasitsa Mountain, south-western Bulgaria. Calcaridorylaimus castaneae sp. n. is characterised by its long body (1.4-2.1 mm), lip region practically not offset, vulva transverse, short odontostyle (14.5-16 ?m) and tail (75.5-110.5 ?m, c=14.7-23.6; c'=2.9-4.4) in females and 38-46 ?m long spicules with small spur before their distant end in males. It is most similar to C. andrassyi Ahmad & Shaheen, 2004, but differs in having transverse vs pore-like vulva and shorter spicules (38-46 ?m vs 52-57 ?m). An identification key to the species of the genus Calcaridorylaimus is proposed. Phylogenetic analyses were performed on 18S and D2-D3 expansion domains of 28S rRNA genes by Neighbor-Joining, Maximum Likelihood and Bayesian Inference methods. The phylograms inferred from 18S sequences showed closest relationships of the new species with some species belonging to the genus Mesodorylaimus. However, insufficient molecular data for members of both genera do not allow the phylogenetic relationships of Calcaridorylaimus and the new species described herein to be elucidated. PMID:24899849

Nedelchev, Sevdan; Elshishka, Milka; Lazarova, Stela; Radoslavov, Georgi; Hristov, Peter; Peneva, Vlada

2014-01-01

489

[Parasitic zoonoses in Japan, with special reference to the current topics].  

PubMed

The present situation of parasitic zoonoses in Japan is reviewed. A total of 51 species, i.e., 6 species of protozoan parasites, 14 species of trematode parasites, 11 species of cestode parasites, 18 species of nematode parasites and 2 species of acanthocephalan parasites are potential zoonotic parasites. Most (11 species) of the zoonotic nematodes provoke larva migrans. Habitats of zoonotic parasites vary greatly depending upon individual species. Some parasites cause heterotopic parasitism (e.g., Paragonimus westermani) and metastasis (Entamoeba histolytica). In larva migrans, parasites migrate through various parts of body tissues, affecting multiple organs (gnathostomiasis and sparganosis mansoni). The majority of parasitic zoonoses are food-borne infections. Some of them are an arthropod-borne (or -mediated) infection (dirofilariasis, thelaziasis and moniliformiasis), or acquired by percutaneous infection with cercariae (schistosome cercarial dermatitis) or 3rd-stage infective larvae (hookworm diseases). The diagnosis of parasitic zoonoses, especially larva migrans, is difficult; although some unique clinical symptoms and the presence of eosinophilia and/or increased level of serum IgE antibody are frequently seen in larva migrans, the application of various immunodiagnostic methods is usually required. For the prevention and control of parasitic zoonoses, the ingestion of not only strange food (e.g., snakes, frogs, slugs, etc.) but also raw fish and cuttlefish (sashimi) must be prohibited. Fishes and the meat of wild animals (e.g., bear and wild boar) should be frozen or thoroughly cooked before eating. Pets and domestic animals play an important role as a direct or indirect source of infection with various parasitic zoonoses. The treatment of those animals and/or the eradication of intermediate hosts (or vectors) of the parasites are thus required. PMID:2513435

Yoshimura, K

1989-11-01

490

The Burden of Parasitic Zoonoses in Nepal: A Systematic Review  

PubMed Central

Background Parasitic zoonoses (PZs) pose a significant but often neglected threat to public health, especially in developing countries. In order to obtain a better understanding of their health impact, summary measures of population health may be calculated, such as the Disability-Adjusted Life Year (DALY). However, the data required to calculate such measures are often not readily available for these diseases, which may lead to a vicious circle of under-recognition and under-funding. Methodology We examined the burden of PZs in Nepal through a systematic review of online and offline data sources. PZs were classified qualitatively according to endemicity, and where possible a quantitative burden assessment was conducted in terms of the annual number of incident cases, deaths and DALYs. Principal Findings Between 2000 and 2012, the highest annual burden was imposed by neurocysticercosis and congenital toxoplasmosis (14,268 DALYs [95% Credibility Interval (CrI): 5450–27,694] and 9255 DALYs [95% CrI: 6135–13,292], respectively), followed by cystic echinococcosis (251 DALYs [95% CrI: 105–458]). Nepal is probably endemic for trichinellosis, toxocarosis, diphyllobothriosis, foodborne trematodosis, taeniosis, and zoonotic intestinal helminthic and protozoal infections, but insufficient data were available to quantify their health impact. Sporadic cases of alveolar echinococcosis, angiostrongylosis, capillariosis, dirofilariosis, gnathostomosis, sparganosis and cutaneous leishmaniosis may occur. Conclusions/Significance In settings with limited surveillance capacity, it is possible to quantify the health impact of PZs and other neglected diseases, thereby interrupting the vicious circle of neglect. In Nepal, we found that several PZs are endemic and are imposing a significant burden to public health, higher than that of malaria, and comparable to that of HIV/AIDS. However, several critical data gaps remain. Enhanced surveillance for the endemic PZs identified in this study would enable additional burden estimates, and a more complete picture of the impact of these diseases. PMID:24392178

Devleesschauwer, Brecht; Ale, Anita; Torgerson, Paul; Praet, Nicolas; Maertens de Noordhout, Charline; Pandey, Basu Dev; Pun, Sher Bahadur; Lake, Rob; Vercruysse, Jozef; Joshi, Durga Datt; Havelaar, Arie H.; Duchateau, Luc; Dorny, Pierre; Speybroeck, Niko

2014-01-01

491

Purification and partial characterization of cysteine proteinase from Spirometra mansoni plerocercoids.  

PubMed

Spirometra mansoni plerocercoids were dissected from the tissues of naturally infected snakes (Natrix trigrialateralia). Fresh plerocercoids were incubated in medium, and excretory-secretory products (E-S) were collected. In addition, soluble proteins from lyophilized plerocercoids (10 mg/ml) were extracted in 0.1 M sodium acetate. Proteinase activity was assayed with a synthetic fluorescent substrate, carbobenzoxy-phenylalanyl-arginyl-7-amino-4-trifluoromethylcoumarin. Proteinase was isolated from plerocercoid extract or E-S by diethylaminoethyl trisacryl M ion-exchange chromatography and thiolpropyl-Sepharose affinity chromatography. These separations resulted in a 12.2- (extract) and 15.6-fold (E-S) purification of proteinase. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis of the purified materials revealed a 28-kDa band, consistent with the apparent native molecular weight (gel filtration chromatography) of approximately 35 kDa. Proteinases purified from whole extracts and E-S were compared for various biochemical characteristics; inhibitor profiles indicated that activities from both sources are cysteine proteinases, they exhibited identical pH curves with optima at pH 5.5 and a 50% activity range at pH 4.7-8.0, they cleaved collagen chains to 3 identical products, and they showed only minor activity toward hemoglobin. Further, the proteinase purified from plerocercoids was utilized in immunoblots with sera from sparganosis patients. Antibody (IgG) from the infected patients, but not uninfected controls, recognized the cysteine proteinase, suggesting that this antigen may be useful in the serodiagnosis of Spirometra mansoni infection. PMID:8331472

Song, C Y; Chappell, C L

1993-08-01

492

Pulmonary Artery Sarcoma Masquerading as Chronic Pulmonary Thromboembolism  

PubMed Central

We describe the case of a 60-year-old woman who presented with pulmonary artery sarcoma, a very rare tumor of the cardiovascular system. Her tumor was initially misdiagnosed as chronic pulmonary thromboembolism, and she underwent pulmonary endarterectomy. Early diagnosis of primary pulmonary artery sarcoma is crucial. That alternative should always be considered before settling on a diagnosis of pulmonary embolism. Suspicion should be aroused by the failure of anticoagulant treatment to alleviate pulmonary perfusion abnormalities and systemic symptoms. Surgical resection of the tumor—preferably by pulmonary endarterectomy, followed by reconstruction as needed—is currently the most promising treatment for pulmonary artery sarcoma. PMID:25425987

Coskun, Ugur; Calpar, Ilknur; Yildizeli, Bedrettin; Yanartas, Mehmet; Filinte, Deniz; Kucukoglu, Mehmet Serdar

2014-01-01

493

Caseous calcification of the mitral annulus: a review.  

PubMed

Caseous calcification of the mitral annulus (CCMA) is a rare variant of mitral annular calcification (MAC). Since most cardiologists are unfamiliar with CCMA, it is commonly misdiagnosed as an abscess, tumor or infective vegetation on the mitral valve. In most cases, conservative management for this lesion is sufficient. In this review, we will discuss the various aspects of this condition and illustrate the gross and histologic pathology as well as various imaging modalities (Ultrasound, Computed tomography, Cardiac Magnetic resonance) to assess this unusual cardiac mass. PMID:24038099

Elgendy, Islam Y; Conti, C Richard

2013-10-01

494

The challenges and surprises of a definitive molecular genetic diagnosis.  

PubMed

Making precise molecular genetic diagnoses in inherited kidney diseases is important. Gee et al. describe families with end-stage renal disease secondary to a presumed diagnosis of a nephronophthisis-related ciliopathy (NPHP-RC), in whom a combination of approaches allowed genetic diagnoses to be made. New genetic approaches to the diagnosis of childhood renal failure are becoming mainstream and will hopefully improve patient management, avoid clinical misdiagnoses, reduce the need for invasive investigations, and allow screening of at-risk relatives. PMID:24682124

Sayer, John A; Simms, Roslyn J

2014-04-01

495

An unusual case of rapidly progressive hyperbilirubinemia.  

PubMed

We present an unusual case of hyperbilirubinemia with rapid early progression leading to bilirubin encephalopathy in a term neonate. Despite early recognition and intervention, the total serum bilirubin reached a maximum level of 39?mg/dL at 32 hours of life. Prior to an emergent exchange transfusion, the patient's diagnostic evaluation was significant for Coombs-negative microangiopathic hemolytic anemia and thrombocytopenia. Further testing revealed a deficiency of ADAMTS13 protein, or von Willebrand factor-cleaving protease, a finding diagnostic of congenital thrombotic thrombocytopenic purpura, or Upshaw-Schulman syndrome. This rare disease is often misdiagnosed, especially in the newborn period. PMID:24288641

Thornton, Kimberly M; Nyp, Michael F; Music Aplenc, Lejla; Jones, Gary L; Carpenter, Shannon L; Guest, Erin M; Shapiro, Steven M; Manimtim, Winston M

2013-01-01

496

Well differentiated liposarcoma of spermatic cord: report of 3 rare cases  

PubMed Central

Spermatic cord liposarcomas are very rare tumors. Patients usually present with painless growing scrotal swellings which are clinically misdiagnosed as hernia. The correct diagnosis is not common and usually they present as operative or histological surprises. To our knowledge, there are about 186 similar cases reported in the literature. Herein we report three cases of spermatic cord liposarcoma with clinical presentation of scrotal bulging, mimicking inguinal hernia in one case and resembling a testicular tumor in the other two cases. The patients were operated and all of them underwent radical orchiectomy and tumor resection. PMID:25250255

Abolhasani, Maryam; Babashahi, Mashaallah; Shooshtarizadeh, Tina; Asgari, Mojgan; Shahrokh, Hossein; Shadpour, Pejman; Emami, Maryam

2014-01-01

497

An anorexic woman with convulsive loss of consciousness. Syncope or epileptic fits?  

PubMed

We report the case of a young anorexic woman who suffered a sudden loss of consciousness with convulsions, diagnosed as epilepsy associated with a migrational disorder, as documented at MRI. Standard 12-lead ECG showed a prolonged QT interval. Biochemical tests revealed a severe hypokalemia. Continuous 24-h ECG recording detected a ventricular tachycardia in torsades de pointes inducing a syncopal convulsive attack that seemed to be related to oral Cisapride assumption for dyspepsia. Discontinuation of cisapride and normalization of kalemia caused disappearance of both ECG abnormalities and loss of consciousness episodes. Syncope is a condition often misdiagnosed as epileptic seizures. PMID:17070606

Attanasio, Antonio; Argiriadou, Vassiliki; Sandri, Giancarlo; Diomedi, Marina

2007-03-20

498

Phosphaturic mesenchymal tumor with chondromyxoid fibroma-like feature: an unusual morphological appearance.  

PubMed

Phosphaturic mesenchymal tumor (PMT) is a rare and distinctive tumor almost always associated with oncogenic osteomalacia. This tumor is often misdiagnosed due to its widely varied histomorphological spectrum. More recently the term PMT or its variants has been used whatever the histomorphological features. Herein, we present a case of a 32-year-old woman who presented with a 2-year history of oncogenic osteomalacia. The clinical examination failed to detect any tumor. The F-18 FDG PET scan and subsequent MRI revealed a tumor in the soft tissues of the right popliteal fossa. The histological features resembled a chondromyxoid fibroma (CMF), a feature documented only in two cases so far. PMID:21533894

Suryawanshi, Pallavi; Agarwal, Manish; Dhake, Rahul; Desai, Saral; Rekhi, Bharat; Reddy, Kishor B; Jambhekar, Nirmala Ajit

2011-11-01

499

Overdiagnosis of Bipolar Disorder: A Critical Analysis of the Literature  

PubMed Central

Bipolar disorder (BD) is considered one of the most disabling mental conditions, with high rates of morbidity, disability, and premature death from suicide. Although BD is often misdiagnosed as major depressive disorder, some attention has recently been drawn to the possibility that BD could be overdiagnosed in some settings. The present paper focuses on a critical analysis of the overdiagnosis issue among bipolar patients. It includes a review of the available literature findings, followed by some recommendations aiming at optimizing the diagnosis of BD and increasing its reliability. PMID:24348150

Ghouse, Amna A.; Sanches, Marsal; Zunta-Soares, Giovana; Swann, Alan C.; Soares, Jair C.

2013-01-01

500

Disseminated tuberculosis in an AIDS/HIV-infected patient.  

PubMed

Disseminated tuberculosis (TB) is commonly seen in HIV-infected patients and is major cause of death in these patients. In HIV-infected patients disseminated tuberculosis is frequently undiagnosed or misdiagnosed. In this article we report a case of disseminated TB in a HIV-infected patient with a relatively long history of fever and other complaints without definite diagnosis. Diagnosis of disseminated TB was confirmed by bone marrow biopsy and polymerase chain reaction analysis (PCR) of the ascitic fluid. With anti-TB treatment signs and symptoms improved. PMID:24026999

Abdi-Liae, Zahra; Moradnejad, Pardis; Alijani, Neda; Khazraiyan, Hamide; Mansoori, Sedigeh; Mohammadi, Naseh

2013-01-01