Advanced designs for non-imaging submillimeter-wave Winston cone concentrators

NASA Astrophysics Data System (ADS)

Nelson, A. O.; Grossman, E. N.

2014-05-01

We describe the design and simulation of several non-imaging concentrators designed to couple submillimeter wavelength radiation from free space into highly overmoded, rectangular, WR-10 waveguide. Previous designs are altered to improve the uniformity of efficiency rather than the efficiency itself. The concentrators are intended for use as adapters between instruments using overmoded WR-10 waveguide as input or output and sources propagating through free space. Previous simulation and measurement have shown that the angular response is primarily determined by the Winston cone and is well predicted by geometric optics theory while the efficiencies are primarily determined by the transition section. Additionally, previous work has shown insensitivity to polarization, orientation and beam size. Several separate concentrator designs are studied, all of which use a Winston cone (also known as a compound parabolic concentrator) with an input diameter ranging from 4 mm to 16 mm, and "throat" diameters of less than 0.5 mm to 4 mm as the initial interface. The use of various length adiabatic circular-to-rectangular transition sections is investigated, along with the effect of an additional, 25 mm waveguide section designed to model the internal waveguide of the power meter. Adapters without a transition section and a rectangular Winston cone throat aperture and double cone configurations are also studied. Adapters are analyzed in simulation for consistent efficiency across the opening aperture.

The historical and palaeoflood record of Katherine river, northern Australia: evaluating the likelihood of extreme discharge events in the context of the 1998 flood

NASA Astrophysics Data System (ADS)

Sandercock, Peter; Wyrwoll, Karl-Heinz

2005-12-01

The discharge regimes of the large rivers of northern Australia are characterized by the occurrence of extreme flood events with far-reaching environmental and societal impacts. In January 1998 the largest flood ever recorded on the Katherine River, northern Australia, resulted in widespread inundation and resultant damage to the town of Katherine. The occurrence of the flood emphasized the unreliability of the then available flood probability estimates and prompted a palaeoflood approach to estimate the recurrence interval of the event. The location of Katherine is ideal for such a study, as the town is located immediately downstream from Katherine Gorge, which provides the necessary bedrock-confined channel required for such an approach. In addition, previous work in Katherine Gorge had demonstrated that the gorge sections hold suitable deposits for palaeoflood stage reconstruction. The results of the present study show that at least two flow events with discharges similar to the 1998 flood have occurred within the last 600 years, and that high-magnitude floods are a general feature of the discharge record of the Katherine River over the last c. 2000 years. Furthermore, because the study was undertaken within a few months of the occurrence of the 1998 flood, it provided the opportunity to evaluate the previously obtained flood discharge estimates and draw attention to the general uncertainties associated with palaeoflood studies. Our results emphasize that palaeoflood stage estimates based on slackwater deposits need to be treated as conservative estimates only. More specifically, with respect to the 1998 event, our study demonstrates that the controls of flood peak were more complex than simply flood routing through the gorge sections. It is clear that the areas downstream from Katherine Gorge made an important contribution to the flood peak of the 1998 event. Copyright

NASCAR Winston Cup Race Results for 1975-2003

ERIC Educational Resources Information Center

Winner, Larry

2006-01-01

Stock car racing has seen tremendous growth in popularity in recent years. We introduce two datasets containing results from all Winston Cup races between 1975 and 2003, inclusive. Students can use any number of statistical methods and applications of basic probability on the data to answer a wide range of practical questions. Instructors and…

Eating high fat chow enhances the locomotor-stimulating effects of cocaine in adolescent and adult female rats.

PubMed

Baladi, Michelle G; Koek, Wouter; Aumann, Megan; Velasco, Fortino; France, Charles P

2012-08-01

Dopamine systems vary through development in a manner that can impact drugs acting on those systems. Dietary factors can also impact the effects of drugs acting on dopamine systems. This study examined whether eating high fat chow alters locomotor effects of cocaine (1-56 mg/kg) in adolescent and adult female rats. Cocaine was studied in rats (n = 6/group) with free access to standard (5.7% fat) or high fat (34.3%) chow or restricted access to high fat chow (body weight matched to rats eating standard chow). After 1 week of eating high fat chow (free or restricted access), sensitivity to cocaine was significantly increased in adolescent and adult rats, compared with rats eating standard chow. Sensitivity to cocaine was also increased in adolescent rats with restricted, but not free, access to high fat chow for 4 weeks. When adolescent and adult rats that previously ate high fat chow ate standard chow, sensitivity to cocaine returned to normal. In adolescent and adult female rats eating high fat chow, but not those eating standard chow, sensitivity to cocaine increased progressively over once weekly tests with cocaine (i.e., sensitization) in a manner that was not statistically different between adolescents and adults. These results show that eating high fat chow alters sensitivity of female rats to acutely administered cocaine and also facilitates the development of sensitization to cocaine. That the type of food consumed can increase drug effects might have relevance to vulnerability to abuse cocaine in the female population.

Winston Churchill's "Iron Curtain" Address: Implications for the Present.

ERIC Educational Resources Information Center

Bush, George

1988-01-01

Evaluates the "Iron Curtain" speech made by Winston Churchill in 1946, discussing its relevance and implications for the present. Examines Churchill's predictions for the future and his assessment of the USSR. Reviews world developments since the speech and proposes foreign policy goals for the next 40 years. (GEA)

Eating high-fat chow enhances sensitization to the effects of methamphetamine on locomotion in rats

PubMed Central

McGuire, Blaine A.; Baladi, Michelle G.; France, Charles P.

2011-01-01

Eating high-fat chow can modify the effects of drugs acting directly or indirectly on dopamine systems and repeated intermittent drug administration can markedly increase sensitivity (i.e., sensitization) to the behavioral effects of indirect-acting dopamine receptor agonists (e.g., methamphetamine). This study examined whether eating high-fat chow alters the sensitivity of male Sprague Dawley rats to the locomotor stimulating effects of acute or repeated administration of methamphetamine. The acute effects of methamphetamine on locomotion were not different between rats (n=6/group) eating high-fat or standard chow for 1 or 4 weeks. Sensitivity to the effects of methamphetamine (0.1–10 mg/kg, i.p.) increased progressively across 4 once per week tests; this sensitization developed more rapidly and to a greater extent in rats eating high-fat chow as compared with rats eating standard chow. Thus, while eating high-fat chow does not appear to alter sensitivity of rats to acutely-administered methamphetamine, it significantly increases the sensitization that develops to repeated intermittent administration of methamphetamine. These data suggest that eating certain foods influences the development of sensitization to drugs acting on dopamine systems. PMID:21371470

Eating high-fat chow enhances sensitization to the effects of methamphetamine on locomotion in rats.

PubMed

McGuire, Blaine A; Baladi, Michelle G; France, Charles P

2011-05-11

Eating high-fat chow can modify the effects of drugs acting directly or indirectly on dopamine systems and repeated intermittent drug administration can markedly increase sensitivity (i.e., sensitization) to the behavioral effects of indirect-acting dopamine receptor agonists (e.g., methamphetamine). This study examined whether eating high-fat chow alters the sensitivity of male Sprague Dawley rats to the locomotor stimulating effects of acute or repeated administration of methamphetamine. The acute effects of methamphetamine on locomotion were not different between rats (n=6/group) eating high-fat or standard chow for 1 or 4 weeks. Sensitivity to the effects of methamphetamine (0.1-10mg/kg, i.p.) increased progressively across 4 once per week tests; this sensitization developed more rapidly and to a greater extent in rats eating high-fat chow as compared with rats eating standard chow. Thus, while eating high-fat chow does not appear to alter sensitivity of rats to acutely-administered methamphetamine, it significantly increases the sensitization that develops to repeated intermittent administration of methamphetamine. These data suggest that eating certain foods influences the development of sensitization to drugs acting on dopamine systems. Copyright © 2011 Elsevier B.V. All rights reserved.

Eating high fat chow increases the sensitivity of rats to 8-OH-DPAT-induced lower lip retraction.

PubMed

Li, Jun-Xu; Ju, Shutian; Baladi, Michelle G; Koek, Wouter; France, Charles P

2011-12-01

Eating high fat food can alter sensitivity to drugs acting on dopamine systems; this study examined whether eating high fat food alters sensitivity to a drug acting on serotonin (5-HT) systems. Sensitivity to (+)-8-hydroxy-2-(dipropylamino) tetralin hydrobromide (8-OH-DPAT; 5-HT1A receptor agonist)-induced lower lip retraction was examined in separate groups (n=8-9) of rats with free access to standard (5.7% fat) or high fat (34.3% fat) chow; sensitivity to quinpirole (dopamine D3/D2 receptor agonist)-induced yawning was also examined. Rats eating high fat chow gained more body weight than rats eating standard chow and, after 6 weeks of eating high fat chow, they were more sensitive to 8-OH-DPAT (0.01-0.1 mg/kg)-induced lower lip retraction and quinpirole (0.0032-0.32 mg/kg)-induced yawning. These changes were not reversed when rats that previously ate high fat chow were switched to eating standard chow and sensitivity to 8-OH-DPAT and quinpirole increased when rats that previously ate standard chow ate high fat chow. These data extend previous results showing changes in sensitivity to drugs acting on dopamine systems in animals eating high fat chow to a drug acting at 5-HT1A receptors and they provide support for the notion that eating certain foods impacts sensitivity to drugs acting on monoamine systems.

Eating high fat chow increases the sensitivity of rats to 8-OH-DPAT-induced lower lip retraction

PubMed Central

Li, Jun-Xu; Ju, Shutian; Baladi, Michelle G; Koek, Wouter; France, Charles P

2011-01-01

Eating high fat food can alter sensitivity to drugs acting on dopamine systems; this study examined whether eating high fat food alters sensitivity to a drug acting on serotonin (5-HT) systems. Sensitivity to (+)-8-hydroxy-2-(dipropylamino) tetralin hydrobromide (8-OH-DPAT; 5-HT1A receptor agonist)-induced lower lip retraction was examined in separate groups (n=8-9) of rats with free access to standard (5.7% fat) or high fat (34.3% fat) chow; sensitivity to quinpirole (dopamine D3/D2 receptor agonist)-induced yawning was also examined. Rats eating high fat chow gained more body weight than rats eating standard chow and, after 6 weeks of eating high fat chow, they were more sensitive to 8-OH-DPAT (0.01-0.1 mg/kg)-induced lower lip retraction and quinpirole (0.0032-0.32 mg/kg)-induced yawning. These changes were not reversed when rats that previously ate high fat chow were switched to eating standard chow and sensitivity to 8-OH-DPAT and quinpirole increased when rats that previously ate standard chow ate high fat chow. These data extend previous results showing changes in sensitivity to drugs acting on dopamine systems in animals eating high fat chow to a drug acting at 5-HT1A receptors and they provide support for the notion that eating certain foods impacts sensitivity to drugs acting on monoamine systems. PMID:21979831

SU-F-T-547: Off-Isocenter Winston-Lutz Test for Stereotactic Radiosurgery/stereotactic Body Radiotherapy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gao, J; Liu, X

2016-06-15

Purpose: To perform a quantitative study to verify that the mechanical field center coincides with the radiation field center when both are off from the isocenter during the single-isocenter technique in linear accelerator-based SRS/SBRT procedure to treat multiple lesions. Methods: We developed an innovative method to measure this accuracy, called the off-isocenter Winston-Lutz test, and here we provide a practical clinical guideline to implement this technique. We used ImagePro V.6 to analyze images of a Winston-Lutz phantom obtained using a Varian 21EX linear accelerator with an electronic portal imaging device, set up as for single-isocenter SRS/SBRT for multiple lesions. Wemore » investigated asymmetry field centers that were 3 cm and 5 cm away from the isocenter, as well as performing the standard Winston-Lutz test. We used a special beam configuration to acquire images while avoiding collision, and we investigated both jaw and multileaf collimation. Results: For the jaw collimator setting, at 3 cm off-isocenter, the mechanical field deviated from the radiation field by about 2.5 mm; at 5 cm, the deviation was above 3 mm, up to 4.27 mm. For the multileaf collimator setting, at 3 cm off-isocenter, the deviation was below 1 mm; at 5 cm, the deviation was above 1 mm, up to 1.72 mm, which is 72% higher than the tolerance threshold. Conclusion: These results indicated that the further the asymmetry field center is from the machine isocenter, the larger the deviation of the mechanical field from the radiation field, and the distance between the center of the asymmetry field and the isocenter should not exceed 3 cm in of our clinic. We recommend that every clinic that uses linear accelerator, multileaf collimator-based SRS/SBRT perform the off-isocenter Winston-Lutz test in addition to the standard Winston-Lutz test and use their own deviation data to design the treatment plan.« less

Pregnancy, Birth, and Infant Health Outcomes from the National Smallpox Health Vaccine in Pregnancy Registry, 2003-2006

DTIC Science & Technology

2008-01-01

PREGNANCY REGISTRY TEAM From the US Department of Defense: Ava Conlin, Brianna Alexander, Rosha Aran- Loach , Katherine Campbell, Shirley Chow, Renata Engler...Sonja S. Hutchins, Kristin Ken - yan, Sheryl B. Lyss, and Joseph Mulinare. Acknowledgments We gratefully acknowledge the support of all of the

Geothermal Exploration of the Winston Graben, Central New Mexico, USA

NASA Astrophysics Data System (ADS)

Sophy, M. J.; Kelley, S. A.

2011-12-01

We are assessing the geothermal potential of the Winston Graben of central New Mexico using borehole temperature logs and geophysical data. The Winston Graben is a late Cenozoic rift basin, part of the larger Rio Grande rift, which is 5 to 10 km wide and 56 km long with northern and southern termini occurring at accommodation zones that coincide with late Cenozoic volcanic lineaments. The graben is interpreted to be symmetric based on geologic mapping, with 2 km of stratigraphic offset on both the western and eastern margins. The graben is bordered by the Black Range to the west and is separated from the Rio Grande valley by the Sierra Cuchillo, a horst block made of Paleozoic rocks intruded by a laccolith. Geothermal and geophysical data, including water table measurements, well temperature logs, thermal conductivity samples, bottom hole temperatures, water chemistry, and gravity data have been extracted from the New Mexico Geothermal Database, part of the National Geothermal Database, and the Geonet Gravity and Magnetic Dataset Repository. Combined with existing geologic maps of the Winston Graben and surroundings, these data help to identify spatial relationships between geologic structures and groundwater parameters and distribution. Geothermal gradients from industry temperature-depth well profiles range from 20°C/km to 60°C/km with a spatial distribution of higher gradients located on the eastern side of the Sierra Cuchillo horst, which is where a mapped warm spring is located. Lower thermal gradients were observed to the west in the groundwater recharge area of the basin. Analysis of Bouguer gravity data indicate a gravity low coinciding with the center of the Winston Graben, which is attributed to be the deepest part of the basin, symetrically surrounded by gravity highs. Gravity highs coincide with the middle Cenozoic Morenci and Chise volcanic lineaments along the northern and southern ends of the graben. The mapped warm spring occurs at the

Magnitudes of nearshore waves generated by tropical cyclone Winston, the strongest landfalling cyclone in South Pacific records. Unprecedented or unremarkable?

NASA Astrophysics Data System (ADS)

Terry, James P.; Lau, A. Y. Annie

2018-02-01

We delimit nearshore storm waves generated by category-5 Tropical Cyclone Winston in February 2016 on the northern Fijian island of Taveuni. Wave magnitudes (heights and flow velocities) are hindcast by inverse modelling, based on the characteristics of large carbonate boulders (maximum 33.8 m3, 60.9 metric tons) that were quarried from reef-front sources, transported and deposited on coral reef platforms during Winston and older extreme events. Results indicate that Winston's storm waves on the seaward-margin of reefs fringing the southeastern coasts of Taveuni reached over 10 m in height and generated flow velocities of 14 m s- 1, thus coinciding with the scale of the biggest ancient storms as estimated from pre-existing boulder evidence. We conclude that although Winston tracked an uncommon path and was described as the most powerful storm on record to make landfall in the Fiji Islands, its coastal wave characteristics were not unprecedented on centennial timescales. At least seven events of comparable magnitude have occurred over the last 400 years.

Skills Planning for Industry Growth: A Case Study of the Katherine Arts Industry. Occasional Paper

ERIC Educational Resources Information Center

Curry, Catherine

2009-01-01

The findings of a cultural industries skills audit undertaken in 2008 in Katherine, Northern Territory, are explored. The case study focusses in particular on the practical challenges and implications of auditing skills in a diverse industry sector and considers the usefulness of such an audit in preparing an industry for predicted change. This…

Sensitivity to apomorphine-induced yawning and hypothermia in rats eating standard or high-fat chow.

PubMed

Baladi, Michelle G; Thomas, Yvonne M; France, Charles P

2012-07-01

Feeding conditions modify sensitivity to indirect- and direct-acting dopamine receptor agonists as well as the development of sensitization to these drugs. This study examined whether feeding condition affects acute sensitivity to apomorphine-induced yawning or changes in sensitivity that occur over repeated drug administration. Quinpirole-induced yawning was also evaluated to see whether sensitization to apomorphine confers cross-sensitization to quinpirole. Drug-induced yawning was measured in different groups of male Sprague Dawley rats (n = 6/group) eating high (34.3%) fat or standard (5.7% fat) chow. Five weeks of eating high-fat chow rendered otherwise drug-naïve rats more sensitive to apomorphine- (0.01-1.0 mg/kg, i.p.) and quinpirole- (0.0032-0.32 mg/kg, i.p.) induced yawning, compared with rats eating standard chow. In other rats, tested weekly with apomorphine, sensitivity to apomorphine-induced yawning increased (sensitization) similarly in rats with free access to standard or high-fat chow; conditioning to the testing environment appeared to contribute to increased yawning in both groups of rats. Food restriction decreased sensitivity to apomorphine-induced yawning across five weekly tests. Rats with free access to standard or high-fat chow and sensitized to apomorphine were cross-sensitized to quinpirole-induced yawning. The hypothermic effects of apomorphine and quinpirole were not different regardless of drug history or feeding condition. Eating high-fat chow or restricting access to food alters sensitivity to direct-acting dopamine receptor agonists (apomorphine, quinpirole), although the relative contribution of drug history and dietary conditions to sensitivity changes appears to vary among agonists.

The effects of nicotine self-administration and withdrawal on concurrently available chow and sucrose intake in adult male rats.

PubMed

Bunney, Patricia E; Burroughs, Danielle; Hernandez, Christine; LeSage, Mark G

2016-02-01

Carbohydrate intake, preference, and taste thresholds may be altered in current and former cigarette smokers, which may mediate weight gain and risk for obesity in individuals who quit smoking. Attempts to model these effects in rodents have primarily used noncontingent nicotine administration. The purpose of this research was to characterize changes in chow and sucrose intake in rats during a 23-h access model of i.v. nicotine self-administration (NSA), in which rats lever-pressed for chow, sucrose, and nicotine under concurrent fixed-ratio (FR) 1 schedules. Male rats were assigned to one of three groups that differed in food and drug availability. The Nicotine C+S group had concurrent access to nicotine, chow, and sucrose. The Saline C+S group had access to saline, chow, and sucrose. The Nicotine C-Only group had access to nicotine and chow, but not sucrose. Changes in food intake and weight gain were assessed during baseline, NSA, and nicotine withdrawal (i.e., saline extinction). Weight gain was significantly slowed during NSA and increased during withdrawal, but did not differ between the nicotine groups. NSA produced a significant decrease in both chow and sucrose intake. Gradual tolerance to nicotine's effects on sucrose, but not chow intake, occurred. During withdrawal, chow and sucrose intake increased, with a larger percent increase in sucrose intake compared to chow. The proportion of total food intake from sucrose was greater at the end of withdrawal compared to baseline, indicating a history of nicotine intake changed dietary preference. Combined, these results indicate that sucrose intake is more resistant to nicotine's appetite suppressant effects and withdrawal from nicotine produces a greater increase in sweet food intake alongside general increases in chow intake. Changes in overall food intake in current and ex-smokers may lead to increased risk for obesity and other health problems, potentially limiting the benefit of quitting smoking. Copyright

The effects of nicotine self-administration and withdrawal on concurrently available chow and sucrose intake in adult male rats

PubMed Central

Bunney, Patricia E.; Burroughs, Danielle; Hernandez, Christine; LeSage, Mark G

2016-01-01

Carbohydrate intake, preference, and taste thresholds may be altered in current and former cigarette smokers, which may mediate weight gain and risk for obesity in individuals who quit smoking. Attempts to model these effects in rodents have primarily used noncontingent nicotine administration. The purpose of this research was to characterize changes in chow and sucrose intake in rats during a 23-h access model of i.v. nicotine self-administration (NSA), in which rats lever-pressed for chow, sucrose, and nicotine under concurrent fixed-ratio (FR) 1 schedules. Male rats were assigned to one of three groups that differed in food and drug availability. The Nicotine C+S group had concurrent access to nicotine, chow, and sucrose. The Saline C+S group had access to saline, chow, and sucrose. The Nicotine C-Only group had access to nicotine and chow, but not sucrose. Changes in food intake and weight gain were assessed during baseline, NSA, and nicotine withdrawal (i.e., saline extinction). Weight gain was significantly slowed during NSA and increased during withdrawal, but did not differ between the nicotine groups. NSA produced a significant decrease in both chow and sucrose intake. Gradual tolerance to nicotine’s effects on sucrose, but not chow intake, occurred. During withdrawal, chow and sucrose intake increased, with a larger percent increase in sucrose intake compared to chow. The proportion of total food intake from sucrose was greater at the end of withdrawal compared to baseline, indicating a history of nicotine intake changed dietary preference. Combined, these results indicate that sucrose intake is more resistant to nicotine’s appetite suppressant effects and withdrawal from nicotine produces a greater increase in sweet food intake alongside general increases in chow intake. Changes in overall food intake in current and ex-smokers may lead to increased risk for obesity and other health problems, potentially limiting the benefit of quitting smoking. PMID

Towards a better Understanding and reducing of the Groundwater Contamination in Saint Katherine area, Sinai, Egypt; Using Remote Sensing and Chemical Analyses

NASA Astrophysics Data System (ADS)

Fekri, A.; Mohamed, L.

2017-12-01

Egypt has a big water shortage problem because of the high population density and the lack of the surface water resources. So it was necessary to identify additional clean water resources and among all of the other alternative water resources, groundwater should be the most appropriate choice for Egyptians to explore and develop. Saint Katherine area is located in the highest mountainous area of southern Sinai including parallel ridges separated by deep wadis which have been cut along faults and fractures and enlarged through intense precipitation events during the old pluvial periods. Katherina volcanics and the surrounding granitic rocks in Saint Katherine area, which are generally impermeable except through fractures such as faults, joints and shear zones, are recharged with 50 mm annual precipitation. The groundwater recharge find a way through sets of interconnected joints to feed the existing wells in the low-lying fault zones. After the St. Katherine Protectorate was activated in 1996, public awareness of the possible harmful impact of the existing inadequate sewage disposal increased. The groundwater contamination (nitrates and coliform bacteria) in St. Katherine area causes health problems such as diarrhea and skin infections due to the use of well water for household purposes. This study will focus on; monitoring, evaluating and cleaning up the contaminant distribution in St. Katherine groundwater, using a conceptual model for the fault control on the groundwater flow in fractured basement aquifers to understand the possible pathways for the contaminated groundwater (using remote sensing data), and by preparing disinfectant tracers. It is known that Coliform bacteria could be treated by using Sulfanilamide drug, but in this study we will modify the Sulfanilamide compounds which are considered as ligands containing N, O, S donor atoms that could be used to uptake the transition metals, and produce a colored complex. The produced complex will work as a

The Effect of Feeding Purified versus Chow Diet on Bone Changes Produced by Hindlimb Suspension of Female Rats

NASA Technical Reports Server (NTRS)

Tou, Janet; Arnaud, Sara B.; Grindeland, Richard; Wade, Charles

2004-01-01

Spaceflight simulation studies use chow diets while spaceflight studies use a semi-purified &et. To determine whether the differences in these diets would affect the changes in unweighted bone, we compared the effects of purified vs chow diet on bone parameters, urinary calcium, plasma estradiol, and urinary corticosterone (CORT) in sexually mature female Sprague-Dawley rats. Rats fed purified AIN-93G or chow diet were kept ambulatory (AMB) or subjected to a spaceflight simulation model of unweighted hindlimbs (HLS) for 38 days. Body mass of treatment groups was similar although food intake and caloric density of the diets differed. Both HLS diet groups showed similar decreases in bone mineral content and mechanical strength in unweighted femurs compared to AMB (p<0.05). However, femur length was lower (p<0.05) in the chow-fed than AIN-93G fed groups. Urinary calcium excretion was greater in chow than AIN-93G fed rats, consistent with the higher level of calcium in the diet. Plasma estradiol was lower in HLS than in AMB fed AIN-93G, but similar in HLS and AMB chow fed groups. Femur mineral content was related to plasma estradiol (r(sup 2) =0.91, p<0.00l). Urinary CORT excretion was increased during initial HLS and elevated in HLS/chow-fed rats. Diets did not appear to affect the osteopenia induced by unweighting, but effects on bone growth, calcium excretion, plasma estradiol and urinary CORT do not support the view that these diets can by used interchangeably in bone studies.

"A Refusal of Strict Patterns of Interpretation": Metaphor, Narrative, and Literary Connections in Katherine Mansfield's "The Fly"

ERIC Educational Resources Information Center

Glotova, Elena

2014-01-01

This paper explores how narrative and metaphor combine to articulate the moral and ideological message in a short story "The Fly" by Katherine Mansfield. The research addresses some of the most popular interpretations of the story that demonstrate its ambiguity and intertextual connections. The story metaphorical language is compared…

Eating High Fat Chow Decreases Dopamine Clearance in Adolescent and Adult Male Rats but Selectively Enhances the Locomotor Stimulating Effects of Cocaine in Adolescents

PubMed Central

Baladi, Michelle G.; Horton, Rebecca E.; Owens, William A.; Daws, Lynette C.

2015-01-01

Background: Feeding conditions can influence dopamine neurotransmission and impact behavioral and neurochemical effects of drugs acting on dopamine systems. This study examined whether eating high fat chow alters the locomotor effects of cocaine and dopamine transporter activity in adolescent (postnatal day 25) and adult (postnatal day 75) male Sprague-Dawley rats. Methods: Dose-response curves for cocaine-induced locomotor activity were generated in rats with free access to either standard or high fat chow or restricted access to high fat chow (body weight matched to rats eating standard chow). Results: Compared with eating standard chow, eating high fat chow increased the sensitivity of adolescent, but not adult, rats to the acute effects of cocaine. When tested once per week, sensitization to the locomotor effects of cocaine was enhanced in adolescent rats eating high fat chow compared with adolescent rats eating standard chow. Sensitization to cocaine was not different among feeding conditions in adults. When adolescent rats that previously ate high fat chow ate standard chow, sensitivity to cocaine returned to normal. As measured by chronoamperometry, dopamine clearance rate in striatum was decreased in both adolescent and adult rats eating high fat chow compared with age-matched rats eating standard chow. Conclusions: These results suggest that high fat diet-induced reductions in dopamine clearance rate do not always correspond to increased sensitivity to the locomotor effects of cocaine, suggesting that mechanisms other than dopamine transporter might play a role. Moreover, in adolescent but not adult rats, eating high fat chow increases sensitivity to cocaine and enhances the sensitization that develops to cocaine. PMID:25805560

Eating high fat chow decreases dopamine clearance in adolescent and adult male rats but selectively enhances the locomotor stimulating effects of cocaine in adolescents.

PubMed

Baladi, Michelle G; Horton, Rebecca E; Owens, William A; Daws, Lynette C; France, Charles P

2015-03-24

Feeding conditions can influence dopamine neurotransmission and impact behavioral and neurochemical effects of drugs acting on dopamine systems. This study examined whether eating high fat chow alters the locomotor effects of cocaine and dopamine transporter activity in adolescent (postnatal day 25) and adult (postnatal day 75) male Sprague-Dawley rats. Dose-response curves for cocaine-induced locomotor activity were generated in rats with free access to either standard or high fat chow or restricted access to high fat chow (body weight matched to rats eating standard chow). Compared with eating standard chow, eating high fat chow increased the sensitivity of adolescent, but not adult, rats to the acute effects of cocaine. When tested once per week, sensitization to the locomotor effects of cocaine was enhanced in adolescent rats eating high fat chow compared with adolescent rats eating standard chow. Sensitization to cocaine was not different among feeding conditions in adults. When adolescent rats that previously ate high fat chow ate standard chow, sensitivity to cocaine returned to normal. As measured by chronoamperometry, dopamine clearance rate in striatum was decreased in both adolescent and adult rats eating high fat chow compared with age-matched rats eating standard chow. These results suggest that high fat diet-induced reductions in dopamine clearance rate do not always correspond to increased sensitivity to the locomotor effects of cocaine, suggesting that mechanisms other than dopamine transporter might play a role. Moreover, in adolescent but not adult rats, eating high fat chow increases sensitivity to cocaine and enhances the sensitization that develops to cocaine. © The Author 2015. Published by Oxford University Press on behalf of CINP.

75 FR 20033 - Winston-Salem Southbound Railway Company-Corporate Family Transaction Exemption-High Point...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-16

... DEPARTMENT OF TRANSPORTATION Surface Transportation Board [STB Finance Docket No. 35338] Winston-Salem Southbound Railway Company--Corporate Family Transaction Exemption--High Point, Thomasville... under 49 CFR 1180.2(d)(3) for a transaction within a corporate family. Applicants state that HPTD will...

Beyond the Criminal Arena: The Justice Studies Program at Winston-Salem State University

ERIC Educational Resources Information Center

Harvey, Lynn K.; Mitchell, Alvin D.

2006-01-01

The justice studies program at Winston-Salem State University (WSSU) is designed to produce a new breed of justice practitioners whose understanding of justice and its administration is broadened to include the political, social, economic, and cultural conditions within which issues of crime and punishment are pursued and addressed. While it…

Alternating or continuous exposure to cafeteria diet leads to similar shifts in gut microbiota compared to chow diet.

PubMed

Kaakoush, Nadeem O; Martire, Sarah I; Raipuria, Mukesh; Mitchell, Hazel M; Nielsen, Shaun; Westbrook, R Fred; Morris, Margaret J

2017-01-01

Overconsumption of energy-rich food is a major contributor to the obesity epidemic. The eating habits of many people are characterized by the cycling between overconsumption of energy-rich foods and dieting, the effects of which on the microbiota are currently unknown. We compared the fecal microbiota of rats either continuously fed chow or palatable cafeteria diet to a "cycled" group switched between the two diets (chow for 4, cafeteria for 3 days/wk, n = 12/group) over 16 wk. Enriched bacterial metabolic pathways were predicted, and a range of metabolic parameters was correlated to microbial taxa and pathways. Cycled rats showed large excursions in food intake on each diet switch. When switched from chow to cafeteria, they overconsumed, and when switched back to chow they underconsumed relative to those maintained on the two diets. Metabolic parameters of cycled rats were intermediate between those of the other diet groups (p < 0.05). The microbiota of cycled rats was nearly indistinguishable from rats under constant cafeteria diet, and both groups were significantly different to the chow group. Correlation analyses identified microbial metabolic pathways associated with an obese phenotype. These data suggest that continuous or intermittent exposure to palatable foods have similar effects on the gut microbiota. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Haloperidol and Rimonabant Increase Delay Discounting in Rats Fed High-Fat and Standard-Chow Diets

PubMed Central

Boomhower, Steven R.; Rasmussen, Erin B.

2016-01-01

The dopamine and endocannabinoid neurotransmitter systems have been implicated in delay discounting, a measure of impulsive choice, and obesity. The current study was designed to determine the extent to which haloperidol and rimonabant affected delay discounting in rats fed standard-chow and high-fat diets. Sprague-Dawley rats were allowed to free-feed under a high-fat diet (4.73 kcal/g) or a standard-chow diet (3.0 kcal/g) for three months. Then, operant sessions began in which rats (n = 9 standard chow; n = 10 high-fat) chose between one sucrose pellet delivered immediately vs. three sucrose pellets after a series of delays. In another condition, carrot-flavored pellets replaced sucrose pellets. After behavior stabilized, acute injections of rimonabant (0.3-10 mg/kg) and haloperidol (0.003-0.1 mg/kg) were administered i.p. before some choice sessions in both pellet conditions. Haloperidol and rimonabant increased discounting in both groups of rats by decreasing percent choice for the larger reinforcer and area-under-the-curve (AUC) values. Rats in the high-fat diet condition demonstrated increased sensitivity to haloperidol compared to chow-fed controls: haloperidol increased discounting in both dietary groups in the sucrose condition,, but only in the high-fat-fed rats in the carrot-pellet condition. These findings indicate that blocking D2 and CB1 receptors results in increased delay discounting, and that a high-fat diet may alter sensitivity to dopaminergic compounds using the delay-discounting task. PMID:25000488

Eating high fat chow increases the sensitivity of rats to quinpirole-induced discriminative stimulus effects and yawning

PubMed Central

Baladi, Michelle G; France, Charles P

2010-01-01

Discriminative stimulus effects of directly-acting dopamine receptor agonists (e.g. quinpirole) appear to be mediated by D3 receptors in free-feeding rats. Free access to high fat chow increases sensitivity to quinpirole-induced yawning and the current study examined whether eating high fat chow increases sensitivity to the discriminative stimulus effects of quinpirole. Five rats discriminated between 0.032 mg/kg quinpirole and vehicle while responding under a continuous reinforcement schedule of stimulus shock termination. When rats had free access to high fat chow (discrimination training was suspended), the quinpirole discrimination dose-response curve shifted leftward, possibly indicating enhanced sensitivity at D3 receptors. In the same rats, both the ascending (mediated by D3 receptors) and descending (mediated by D2 receptors) limbs of the dose- response curve for quinpirole-induced yawning shifted leftward. When rats had free access to a standard chow (discrimination training was suspended), the quinpirole discrimination and yawning dose-response curves did not change. Together with published data showing that the discriminative stimulus effects of quinpirole in free- feeding rats are mediated by D3 receptors and the insensitivity of this effect of quinpirole to food restriction (shown to increase sensitivity to D2 but not D3-mediated effects), these results suggest that the leftward shift of the discrimination dose-response curve when rats eat high fat chow is likely due to enhanced sensitivity at D3 receptors. Thus, eating high fat food enhances drug effects in a manner that might impact clinical effects of drugs or vulnerability to drug abuse. PMID:20729718

Eating high-fat chow increases the sensitivity of rats to quinpirole-induced discriminative stimulus effects and yawning.

PubMed

Baladi, Michelle G; France, Charles P

2010-10-01

Discriminative stimulus effects of direct acting dopamine receptor agonists (e.g. quinpirole) appear to be mediated by D3 receptors in free-feeding rats. Free access to high-fat chow increases sensitivity to quinpirole-induced yawning, and this study examined whether eating high-fat chow increases sensitivity to the discriminative stimulus effects of quinpirole. Five rats discriminated between 0.032 mg/kg quinpirole and vehicle while responding under a continuous reinforcement schedule of stimulus shock termination. When rats had free access to high-fat chow (discrimination training was suspended), the quinpirole discrimination dose-response curve shifted leftward, possibly indicating enhanced sensitivity at D3 receptors. In the same rats, both the ascending (mediated by D3 receptors) and descending (mediated by D2 receptors) limbs of the dose-response curve for quinpirole-induced yawning shifted leftward. When rats had free access to a standard chow (discrimination training was suspended), the quinpirole discrimination and yawning dose-response curves did not change. Together with published data showing that the discriminative stimulus effects of quinpirole in free-feeding rats are mediated by D3 receptors and the insensitivity of this effect of quinpirole to food restriction (shown to increase sensitivity to D2 but not D3-mediated effects), these results suggest that the leftward shift of the discrimination dose-response curve when rats eat high-fat chow is likely because of enhanced sensitivity at D3 receptors. Thus, eating high-fat food enhances drug effects in a manner that might impact clinical effects of drugs or vulnerability to drug abuse.

The Medicines of Katherine, Duchess of Norfolk, 1463–71

PubMed Central

Kleineke, Hannes

2015-01-01

This article discusses the medicinal remedies consumed at the court of the Yorkist kings of England in the light of a lawsuit in the court of common pleas (edited in an appendix) between John Clerk, king’s apothecary to Edward IV, and Katherine Neville, Duchess of Norfolk, over the partial non-payment of the apothecary’s bills. It argues that the consumption of apothecaries’ wares in large quantities was not merely a direct result of the excessive diet of the late medieval aristocracy, but in itself represented a facet of the conspicuous consumption inherent in the lifestyle of this particular social class. The remedies supplied by Clerk over a period of several years and listed in the legal record are set in the context of contemporary collections of medical recipes, particularly a ‘dispensary’ in the British Library’s Harleian collection generally attributed to the king’s apothecary. PMID:26352302

Effects of long-term cycling between palatable cafeteria diet and regular chow on intake, eating patterns, and response to saccharin and sucrose.

PubMed

Martire, Sarah I; Westbrook, R Fred; Morris, Margaret J

2015-02-01

When exposed to a diet containing foods that are rich in fat and sugar, rats eat to excess and gain weight. We examined the effects of alternating this diet with laboratory chow on intake of each type of diet, the eating elicited by a palatable food (biscuits), and the drinking elicited by sweet solutions that did (sucrose) or did not (saccharin) contain calories. Each week for 13 weeks, cycled rats were provided with the cafeteria diet for three successive days/nights and the chow diet for the remaining four days/nights, whereas other rats received continuous access to either the cafeteria or the chow diets. On each of the 13 weeks, cycled rats ate more across the first 24 hour exposure to the cafeteria diet than rats continuously fed this diet. In contrast, cycled rats ate less across the first 24 hour exposure to the chow diet than rats continuously fed this diet and ate less when presented a novel palatable biscuit than chow-fed rats. The three groups exhibited similar licks per cluster to saccharin, but cafeteria-fed and cycled rats showed fewer clusters than chow-fed rats. In contrast, chow-fed rats and cycled rats exhibited more licks per cluster to sucrose than cafeteria-fed rats, but all three groups had a similar number of clusters. The results were discussed in relation to the effects of diet cycling on eating patterns, body weight, and 'wanting' and 'liking'. These findings with rats may have important implications for yo-yo dieting in people. Copyright © 2014 Elsevier Inc. All rights reserved.

The California 500: medical care at a NASCAR Winston Cup race.

PubMed

Grange, Jeff T; Baumann, Gregory W

2002-01-01

Stock car racing is America's fastest-growing professional sport. With more than 5.5 million paid admittances and another 148 million watching the 34-race NASCAR Winston Cup series on television, emergency physicians are increasingly called upon to organize medical support for such events. Currently, little reliable information is available to assist in determining what specific personnel and equipment are necessary to optimally support a race event. To characterize the spectrum of presenting injuries and illnesses at a NASCAR Winston Cup event. This study was a retrospective review of all patients presenting to nine on-site first aid stations from June 19 to 22, 1997, for the inaugural California 500 race weekend at California Speedway in Fontana, California. Staffing of the nine first aid stations was provided by 20 paramedics, 25 emergency nurses, five emergency physicians, nine advanced life support (ALS) ambulances with two crew members each, and a medically configured helicopter with flight crew. Of the 923 patients seen, 38 were drivers/crew, 230 were track employees, and 644 were spectators. One hundred thirty-six of the patients were treated in the two infield facilities, while 787 were treated in the grandstand first aid stations. Patients seen per hour peaked just before the start of the race at 73 patients seen. Of the ten patients transported to the hospital, three required admission. No deaths occurred. These data may assist individuals planning medical support for large motorsports venues.

Body Composition of Rats on NASA Rodent Foodbar Versus Purina Lab Chow

NASA Technical Reports Server (NTRS)

Yu, Diane Sau Mun; Dalton, Bonnie P.; Barrett, Joyce E.

2002-01-01

The objective of this study is to test the nutritional adequacy of the NASA Rodent Foodbar for long term use for rats. The Foodbar was tested on two rat strains, Sprague Dawley and Fischer 344. Rats were fed either Foodbar or the control diet, Purina Chow #5012. Body composition analysis was performed on a selected number of samples (n=6 for each gender and treatment group) as part of extensive testing of the Foodbar. Water, fat, ash, and protein (and their percentages) for both treatment groups were compared. Sprague Dawley Foodbar fed rats had a lower % protein than Chow fed rats (25.8% vs. 30.0%). In addition, Sprague Dawley females fed Foodbar had higher total fat (42.1g vs. 24.6g) and % fat (16.4% vs. 10.5%), but lower % water (51.3% vs. 54.8%) than Sprague Dawley females fed Chow. Fischer 344 Foodbar fed rats had a lower % water (47.4% vs. 49,3%) and total water (93.2g vs. 99.6g). In addition, Fischer 344 Foodbar males had higher % fat (17.0% vs. 13.8%) and total fat (43.0g vs. 34.7g). The data suggests that body composition of Foodbar fed rats tends to have lower water content but a higher fat content compared to controls, but not all results are the same for different strains and even different genders within the same strains. The data obtained here, in addition to other data, helps provide a better understanding of the nutritional adequacy of the Foodbar and whether the formula may need to be modified.

The VMAT-2 Inhibitor Tetrabenazine Affects Effort-Related Decision Making in a Progressive Ratio/Chow Feeding Choice Task: Reversal with Antidepressant Drugs

PubMed Central

Randall, Patrick A.; Lee, Christie A.; Nunes, Eric J.; Yohn, Samantha E.; Nowak, Victoria; Khan, Bilal; Shah, Priya; Pandit, Saagar; Vemuri, V. Kiran; Makriyannis, Alex; Baqi, Younis; Müller, Christa E.; Correa, Merce; Salamone, John D.

2014-01-01

Behavioral activation is a fundamental feature of motivation, and organisms frequently make effort-related decisions based upon evaluations of reinforcement value and response costs. Furthermore, people with major depression and other disorders often show anergia, psychomotor retardation, fatigue, and alterations in effort-related decision making. Tasks measuring effort-based decision making can be used as animal models of the motivational symptoms of depression, and the present studies characterized the effort-related effects of the vesicular monoamine transport (VMAT-2) inhibitor tetrabenazine. Tetrabenazine induces depressive symptoms in humans, and also preferentially depletes dopamine (DA). Rats were assessed using a concurrent progressive ratio (PROG)/chow feeding task, in which they can either lever press on a PROG schedule for preferred high-carbohydrate food, or approach and consume a less-preferred lab chow that is freely available in the chamber. Previous work has shown that the DA antagonist haloperidol reduced PROG work output on this task, but did not reduce chow intake, effects that differed substantially from those of reinforcer devaluation or appetite suppressant drugs. The present work demonstrated that tetrabenazine produced an effort-related shift in responding on the PROG/chow procedure, reducing lever presses, highest ratio achieved and time spent responding, but not reducing chow intake. Similar effects were produced by administration of the subtype selective DA antagonists ecopipam (D1) and eticlopride (D2), but not by the cannabinoid CB1 receptor neutral antagonist and putative appetite suppressant AM 4413, which suppressed both lever pressing and chow intake. The adenosine A2A antagonist MSX-3, the antidepressant and catecholamine uptake inhibitor bupropion, and the MAO-B inhibitor deprenyl, all reversed the impairments induced by tetrabenazine. This work demonstrates the potential utility of the PROG/chow procedure as a rodent model of

The VMAT-2 inhibitor tetrabenazine affects effort-related decision making in a progressive ratio/chow feeding choice task: reversal with antidepressant drugs.

PubMed

Randall, Patrick A; Lee, Christie A; Nunes, Eric J; Yohn, Samantha E; Nowak, Victoria; Khan, Bilal; Shah, Priya; Pandit, Saagar; Vemuri, V Kiran; Makriyannis, Alex; Baqi, Younis; Müller, Christa E; Correa, Merce; Salamone, John D

2014-01-01

Behavioral activation is a fundamental feature of motivation, and organisms frequently make effort-related decisions based upon evaluations of reinforcement value and response costs. Furthermore, people with major depression and other disorders often show anergia, psychomotor retardation, fatigue, and alterations in effort-related decision making. Tasks measuring effort-based decision making can be used as animal models of the motivational symptoms of depression, and the present studies characterized the effort-related effects of the vesicular monoamine transport (VMAT-2) inhibitor tetrabenazine. Tetrabenazine induces depressive symptoms in humans, and also preferentially depletes dopamine (DA). Rats were assessed using a concurrent progressive ratio (PROG)/chow feeding task, in which they can either lever press on a PROG schedule for preferred high-carbohydrate food, or approach and consume a less-preferred lab chow that is freely available in the chamber. Previous work has shown that the DA antagonist haloperidol reduced PROG work output on this task, but did not reduce chow intake, effects that differed substantially from those of reinforcer devaluation or appetite suppressant drugs. The present work demonstrated that tetrabenazine produced an effort-related shift in responding on the PROG/chow procedure, reducing lever presses, highest ratio achieved and time spent responding, but not reducing chow intake. Similar effects were produced by administration of the subtype selective DA antagonists ecopipam (D1) and eticlopride (D2), but not by the cannabinoid CB1 receptor neutral antagonist and putative appetite suppressant AM 4413, which suppressed both lever pressing and chow intake. The adenosine A2A antagonist MSX-3, the antidepressant and catecholamine uptake inhibitor bupropion, and the MAO-B inhibitor deprenyl, all reversed the impairments induced by tetrabenazine. This work demonstrates the potential utility of the PROG/chow procedure as a rodent model of

Influence of body weight and type of chow on the sensitivity of rats to the behavioral effects of the direct-acting dopamine-receptor agonist quinpirole.

PubMed

Baladi, Michelle G; Newman, Amy H; France, Charles P

2011-10-01

Amount and type of food can alter dopamine systems and sensitivity to drugs acting on those systems. This study examined whether changes in body weight, food type, or both body weight and food type contribute to these effects. Rats had free or restricted access (increasing, decreasing, or maintaining body weight) to standard (5.7% fat) or high-fat (34.3%) chow. In rats gaining weight with restricted or free access to high-fat chow, both limbs of the quinpirole yawning dose-response curve (0.0032-0.32 mg/kg) shifted leftward compared with rats eating standard chow. Restricting access to standard or high-fat chow (maintaining or decreasing body weight) decreased or eliminated quinpirole-induced yawning; within 1 week of resuming free feeding, sensitivity to quinpirole was restored, although the descending limb of the dose-response curve was shifted leftward in rats eating high-fat chow. These are not likely pharmacokinetic differences because quinpirole-induced hypothermia was not different among groups. PG01037 and L-741,626 antagonized the ascending and descending limbs of the quinpirole dose-response curve in rats eating high-fat chow, indicating D3 and D2 receptor mediation, respectively. Rats eating high-fat chow also developed insulin resistance. These results show that amount and type of chow alter sensitivity to a direct-acting dopamine-receptor agonist with the impact of each factor depending on whether body weight increases, decreases, or is maintained. These data demonstrate that feeding conditions, perhaps related to insulin and insulin sensitivity, profoundly impact the actions of drugs acting on dopamine systems.

Astronauts Brian Duffy, in commander's seat, and Winston E. Scott discuss their scheduled flight

NASA Technical Reports Server (NTRS)

1996-01-01

STS-72 TRAINING VIEW --- Astronauts Brian Duffy, in commander's seat, and Winston E. Scott discuss their scheduled flight aboard the Space Shuttle Endeavour. The two are on the flight deck of the Johnson Space Center's (JSC) fixed base Shuttle Mission Simulator (SMS). Duffy, mission commander, and Scott, mission specialist, will be joined for the winter flight by three other NASA astronauts and an international mission specialist representing NASDA.

Influence of body weight and type of chow on the sensitivity of rats to the behavioral effects of the direct-acting dopamine receptor agonist quinpirole

PubMed Central

Baladi, Michelle G; Newman, Amy H; France, Charles P

2013-01-01

Rationale Amount and type of food can alter dopamine systems and sensitivity to drugs acting on those systems. Objectives This study examined whether changes in body weight, food type, or both body weight and food type contribute to these effects. Methods Rats had free or restricted access (increasing, decreasing, or maintaining body weight) to standard (5.7% fat) or high fat (34.3%) chow. Results In rats gaining weight with restricted or free access to high fat chow, both limbs of the quinpirole yawning dose-response curve (0.0032–0.32 mg/kg) shifted leftward compared with rats eating standard chow. Restricting access to standard or high fat chow (maintaining or decreasing body weight) decreased or eliminated quinpirole-induced yawning; within one week of resuming free feeding, sensitivity to quinpirole was restored, although the descending limb of the dose-response curve was shifted leftward in rats eating high fat chow. These are not likely pharmacokinetic differences because quinpirole-induced hypothermia was not different among groups. PG01037 and L-741,626 antagonized the ascending and descending limbs of the quinpirole dose-response curve in rats eating high fat chow, indicating D3 and D2 receptor mediation, respectively. Rats eating high fat chow also developed insulin resistance. Conclusions These results show that amount and type of chow alter sensitivity to a direct-acting dopamine receptor agonist with the impact of each factor depending on whether body weight increases, decreases, or is maintained. These data demonstrate that feeding conditions, perhaps related to insulin and insulin sensitivity, profoundly impact the actions of drugs acting on dopamine systems. PMID:21544521

Learning To Lead: How Winston Churchill And George Marshall Harvested Their WWI Experience

DTIC Science & Technology

2014-04-01

Borton’s developmental model. Rolfe and Borton references are provided in Bibliography. 4 Kolb , and Kolb . “ Experiential Learning Theory ,” 39. 5...electronically at http://www2.glos.ac.uk/ gdn/gibbs/index.htm Kolb , Alice Y. and David A. Kolb . “ Experiential Learning Theory : A Dynamic, Holistic...1 EXPERIENTIAL LEARNING THEORY ………………………………………………………..2 THE POWER OF SIX—WINSTON

75 FR 76040 - Dell Products LP, Winston-Salem (WS-1) Division, Including On-Site Leased Workers From Adecco...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-07

..., Winston-Salem, North Carolina. The notice was published in the Federal Register on April 23, 2010 (75 FR... from Staffing Solutions, South East, and Omni Resources and Recovery. The notices were published in the... firm. The workers are engaged in employment related to the production of desktop computers. New...

76 FR 2710 - Dell Products LP, Winston-Salem (WS-1) Division, Including On-Site Leased Workers From Adecco...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-14

..., APN and ICONMA, Winston-Salem, North Carolina. The notice was published in the Federal Register on... Seaton Corporation. The notices were published on the Federal Register on April 19, 2010 (75 FR 20385... workers are engaged in employment related to the production of desktop computers. New information shows...

Winston Churchill (1874-1965), Dr Robson Roose, MD Brux, FRCPE (1848-1905) and Dr Joseph Rutter, MD Lond, MRCP (1834-1913): Treatment for pneumonia in March 1886.

PubMed

Vale, J Allister; Scadding, John W

2018-01-01

This paper will review Winston Churchill's severe respiratory illness in March 1886 when he developed pneumonia of the right lung as an 11-year-old boy. Winston was treated supportively with 'nourishment, stimulants [probably alcohol] and close watching' at his school by the 'celebrated' family physician, Dr Robson Roose, with the assistance of Dr Joseph Rutter. Roose was exemplary in his commitment to his young patient and assiduous in informing Lord Randolph Churchill of his son's clinical progress by letter.

MaRIE 1.0: A briefing to Katherine Richardson-McDaniel, Staff Member for U. S. Senator Martin Heinrich (D-NM)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Barnes, Cris William

At the request of Katherine Richardson-McDaniel, Staff Member to U.S. Senator Martin Heinrich (D-NM), a high-level briefing was requested about MaRIE 1.0, the Matter-Radiation Interactions in Extremes effort at Los Alamos National Laboratory. What it would be, the mission need motivation, the scientific challenge, and the current favorable impact on both programs and people are shown in viewgraph form.

The (Failed) Case of the Winston Society Wikispace: Challenges and Opportunities of Web 2.0 and Teacher Education

ERIC Educational Resources Information Center

Brass, Jory; Mecoli, Storey

2011-01-01

This article examines the case of the Winston Society, a short-lived wikispace created by a high school English teacher to foster collaborative knowledge-making and social activism among educators. Through an examination of the wiki, questionnaires, and a focal group interview, this paper describes an examination of reasons the "Winston…

Monuments to Academic Carelessness: The Self-fulfilling Prophecy of Katherine Frost Bruner.

PubMed

Rekdal, Ole Bjørn

2014-09-01

In 1942, Katherine Frost Bruner published an article titled "Of psychological writing: Being some valedictory remarks on style." It was published in Journal of Abnormal and Social Psychology , the journal for which she served as editorial assistant between 1937 and 1941. Her collection of advice to writing scholars has been widely quoted, including by several editions of The Publication Manual of the American Psychological Association . The most frequently quoted message in Bruner's article deals with the importance of making sure that references in academic texts are complete and accurate. Exploring the citation history of this particular message reveals an ironic point: the great majority of those who have quoted Bruner's words on reference accuracy have not done so accurately. The case may serve as a reminder of the importance of the basic academic principle of striving to use primary sources. The most startling finding in this study is how frequently this principle is violated, even by authors who advise and educate academic writers.

Acute ghrelin changes food preference from a high-fat diet to chow during binge-like eating in rodents.

PubMed

Bake, T; Hellgren, K T; Dickson, S L

2017-04-01

Ghrelin, an orexigenic hormone released from the empty stomach, provides a gut-brain signal that promotes many appetitive behaviours, including anticipatory and goal-directed behaviours for palatable treats high in sugar and/or fat. In the present study, we aimed to determine whether ghrelin is able to influence and/or may even have a role in binge-like eating behaviour in rodents. Accordingly, we used a palatable scheduled feeding (PSF) paradigm in which ad lib. chow-fed rodents are trained to 'binge' on a high-fat diet (HFD) offered each day for a limited period of 2 hours. After 2 weeks of habituation to this paradigm, on the test day and immediately prior to the 2-hour PSF, rats were administered ghrelin or vehicle solution by the i.c.v. route. Remarkably and unexpectedly, during the palatable scheduled feed, when rats normally only binge on the HFD, those injected with i.c.v. ghrelin started to eat more chow and chow intake remained above baseline for the rest of the 24-hour day. We identify the ventral tegmental area (VTA) (a key brain area involved in food reward) as a substrate involved because these effects could be reproduced, in part, by intra-VTA delivery of ghrelin. Fasting, which increases endogenous ghrelin, immediately prior to a palatable schedule feed also increased chow intake during/after the schedule feed but, in contrast to ghrelin injection, did not reduce HFD intake. Chronic continuous central ghrelin infusion over several weeks enhanced binge-like behaviour in palatable schedule fed rats. Over a 4-week period, GHS-R1A-KO mice were able to adapt and maintain large meals of HFD in a manner similar to wild-type mice, suggesting that ghrelin signalling may not have a critical role in the acquisition or maintenance in this kind of feeding behaviour. In conclusion, ghrelin appears to act as a modulating factor for binge-like eating behaviour by shifting food preference towards a more nutritious choice (from HFD to chow), with these effects

Effect of proximal versus distal 50% enterectomy on nutritional parameters in rats preconditioned with a high-fat diet or regular chow.

PubMed

Yanala, Ujwal R; Reidelberger, Roger D; Thompson, Jon S; Shostrom, Valerie K; Carlson, Mark A

2015-11-27

Obesity may protect against the nutritional consequences of short bowel syndrome. We hypothesized that rats preconditioned with an obesogenic diet would have better outcomes after surgical induction of short bowel syndrome compared to rats on regular chow. Rats were fed a high-fat diet or regular rat chow for six months, and then underwent 50% proximal, 50% distal, or sham enterectomy. Food intake, weight, and body composition were monitored before and for 4 weeks after surgery. The high-fat diet consistently produced obesity (>25% body fat). All procedures induced weight loss, but there was no discernable difference between resection vs. sham resection. Rats on the high-fat diet had a greater post-resection loss of body fat compared to rats on chow (36 vs. 26 g, respectively). There was a nonsignificant trend of less lean mass loss in the former compared to the latter rats (16 vs. 33 g, respectively). Enterectomy moderated serum ghrelin, GIP, PPY, insulin, and leptin. Intestinal adaptation was not different between obese vs. non-obese rats. Rats preconditioned with the high-fat diet may have had better retention of lean body mass after a surgical procedure compared to rats on chow. The effect of 50% enterectomy was less than expected.

9 CFR 319.311 - Chow mein vegetables with meat, and chop suey vegetables with meat.

Code of Federal Regulations, 2010 CFR

2010-01-01

... chop suey vegetables with meat. 319.311 Section 319.311 Animals and Animal Products FOOD SAFETY AND... PRODUCTS INSPECTION AND VOLUNTARY INSPECTION AND CERTIFICATION DEFINITIONS AND STANDARDS OF IDENTITY OR COMPOSITION Canned, Frozen, or Dehydrated Meat Food Products § 319.311 Chow mein vegetables with meat, and...

9 CFR 319.311 - Chow mein vegetables with meat, and chop suey vegetables with meat.

Code of Federal Regulations, 2011 CFR

2011-01-01

... chop suey vegetables with meat. 319.311 Section 319.311 Animals and Animal Products FOOD SAFETY AND... PRODUCTS INSPECTION AND VOLUNTARY INSPECTION AND CERTIFICATION DEFINITIONS AND STANDARDS OF IDENTITY OR COMPOSITION Canned, Frozen, or Dehydrated Meat Food Products § 319.311 Chow mein vegetables with meat, and...

Studies in Teaching: 2002 Research Digest. Research Projects Presented at Annual Research Forum (Winston-Salem, North Carolina, December 2002)

ERIC Educational Resources Information Center

McCoy, Leah P., Ed.

2002-01-01

This document presents the of an annual educational research forum held at Wake Forest University (Winston-Salem, North Carolina) on December 11, 2002. A table of contents and 27 research studies of high school teaching are included. Studies include: Effects of the Earth/Environmental Science Requirement on High School Science Enrollment in North…

Chow groups of intersections of quadrics via homological projective duality and (Jacobians of) non-commutative motives

NASA Astrophysics Data System (ADS)

Bernardara, M.; Tabuada, G.

2016-06-01

Conjectures of Beilinson-Bloch type predict that the low-degree rational Chow groups of intersections of quadrics are one-dimensional. This conjecture was proved by Otwinowska in [20]. By making use of homological projective duality and the recent theory of (Jacobians of) non-commutative motives, we give an alternative proof of this conjecture in the case of a complete intersection of either two quadrics or three odd-dimensional quadrics. Moreover, we prove that in these cases the unique non-trivial algebraic Jacobian is the middle one. As an application, we make use of Vial's work [26], [27] to describe the rational Chow motives of these complete intersections and show that smooth fibrations into such complete intersections over bases S of small dimension satisfy Murre's conjecture (when \\dim (S)≤ 1), Grothendieck's standard conjecture of Lefschetz type (when \\dim (S)≤ 2), and Hodge's conjecture (when \\dim(S)≤ 3).

Studies in Teaching: 2007 Research Digest. Research Projects Presented at Annual Research Forum (Winston-Salem, North Carolina, December 12, 2007)

ERIC Educational Resources Information Center

McCoy, Leah P., Ed.

2007-01-01

These Proceedings document an educational research forum held at Wake Forest University (Winston-Salem, North Carolina) on December 12, 2007. Table of contents and 23 research studies of high school teaching are included. Each paper contains a literature review, methodology, results, conclusions, and references. Studies include: (1) Cultural…

Studies in Teaching: 2005 Research Digest. Research Projects Presented at Annual Research Forum (Winston-Salem, North Carolina, December 7, 2005)

ERIC Educational Resources Information Center

McCoy, Leah P., Ed.

2005-01-01

These Proceedings document an educational research forum held at Wake Forest University (Winston-Salem, North Carolina) on December 7, 2005. Table of contents and 26 research studies of high school teaching are included. Studies include: (1) Mathematical Reasoning in Multiple Representations: Connections and Confidence (Justin Allman); (2) The…

Studies in Teaching: 2006 Research Digest. Research Projects Presented at Annual Research Forum (Winston-Salem, North Carolina, December 6, 2006)

ERIC Educational Resources Information Center

McCoy, Leah P., Ed.

2006-01-01

These Proceedings document an educational research forum held at Wake Forest University (Winston-Salem, North Carolina) on December 6, 2006. Table of contents and 27 research studies of high school teaching are included. Studies include: (1) A Study of Teachers' Perceptions of High School Mathematics Instructional Methods (Caroline Adkisson); (2)…

Studies in Teaching: 2003 Research Digest. Research Projects Presented at Annual Research Forum (Winston-Salem, North Carolina, December 10, 2003)

ERIC Educational Resources Information Center

McCoy, Leah P., Ed.

2003-01-01

This document presents the proceedings of an annual educational research forum held at Wake Forest University (Winston-Salem, North Carolina) on December 10, 2003. A table of contents and 31 research studies of high school teaching are included. The following studies are included: (1) No, Seriously: Humor Use by High School Social Studies Teachers…

Studies in Teaching: 2011 Research Digest. Research Projects Presented at Annual Research Forum (Winston-Salem, North Carolina, June 15, 2011)

ERIC Educational Resources Information Center

McCoy, Leah P., Ed.

2011-01-01

This document presents the proceedings of 16th Annual Research Forum held June 15, 2011, at Wake Forest University in Winston-Salem, North Carolina. Included herein are the following 25 action research papers: (1) The Effects of Prompted Math Journaling on Algebra 1 Students' Achievement and Attitudes (Heidi I. Arnold); (2) Group Work and Attitude…

Studies in Teaching: 2014 Research Digest. Action Research Projects Presented at Annual Research Forum (Winston-Salem, NC, June 26, 2014)

ERIC Educational Resources Information Center

McCoy, Leah P., Ed.

2014-01-01

This document presents the proceedings of the 19th Annual Research Forum held June 26, 2014, at Wake Forest University in Winston-Salem, North Carolina. Included are the following 17 action research papers: (1) Using Voices to Change Minds: Oral Performance and Poetry in the English Classroom (Erika Bunpermkoon), (2) Imagining Audiences: The Use…

Studies in Teaching: 2013 Research Digest. Action Research Projects Presented at Annual Research Forum (Winston-Salem, North Carolina, June 26, 2013)

ERIC Educational Resources Information Center

McCoy, Leah P., Ed.

2013-01-01

This document presents the proceedings of the 18th Annual Research Forum held June 26, 2013, at Wake Forest University in Winston-Salem, North Carolina. Included are the following 13 action research papers: (1) Developing Oral Language Ability in the Secondary Spanish Classroom Using the Interpersonal and Presentational Modes of Communication…

Studies in Teaching: 2017 Research Digest. Action Research Projects Presented at Annual Research Forum (Winston-Salem, North Carolina, June 29, 2017)

ERIC Educational Resources Information Center

McCoy, Leah P., Ed.

2017-01-01

This document presents the proceedings of the 22nd Annual Research Forum held June 29, 2017, at Wake Forest University in Winston-Salem, North Carolina. Included are the following 12 action research papers: (1) Using Captioned Video to Teach Listening Comprehension in a Spanish Classroom (Michelle Allen); (2) Multimodal Instruction: How Film…

Intravenous administration of oxytocin in rats acutely decreases deprivation-induced chow intake, but it fails to affect consumption of palatable solutions.

PubMed

Klockars, Anica; Brunton, Chloe; Li, Lu; Levine, Allen S; Olszewski, Pawel K

2017-07-01

Despite its limited ability to cross the blood-brain barrier, peripherally administered oxytocin (OT) acutely decreases food intake, most likely via the brainstem and hypothalamic mechanisms. Studies performed to date have focused mainly on the effects of subcutaneous or intraperitoneal OT on the consumption of only solid calorie-dense diets (either standard or high-fat), whereas it is unknown whether, similarly to central OT, peripherally administered peptide reduces intake of calorie-dilute and non-caloric palatable solutions. In this project, we established that 0.1μg/kg intravenous (IV) OT is the lowest anorexigenic dose, decreasing deprivation-induced standard chow intake by ca. 40% in rats and its effect does not stem from aversion. We then used this dose in paradigms in which effects of centrally acting OT ligands on consumption of palatable solutions had been previously reported. We found that IV OT did not change episodic intake of individually presented palatable solutions containing 10% sucrose, 0.1% saccharin, combined 10% sucrose-0.1% saccharin or 4.1%. Intralipid and it failed to affect daily scheduled consumption of a sucrose solution in non-deprived rats. In a two-bottle choice test, IV OT did not shift animals' preference from sucrose to Intralipid. Finally, OT injected IV prior to the simultaneous presentation chow and a sucrose solution in food-deprived rats significantly decreased chow intake, whereas sugar water consumption remained unchanged. We conclude that IV OT reduces deprivation-induced chow intake without causing aversion, but the dose effective in decreasing energy-driven consumption of high-calorie food fails to affect consumption of palatable calorie-dilute solutions. Copyright © 2017 Elsevier Inc. All rights reserved.

Studies in Teaching: 2012 Research Digest. Action Research Projects Presented at Annual Research Forum (Winston-Salem, North Carolina, June 29, 2012)

ERIC Educational Resources Information Center

McCoy, Leah P., Ed.

2012-01-01

This document presents the proceedings of the 17th Annual Research Forum held June 29, 2012, at Wake Forest University in Winston-Salem, North Carolina. Included herein are the following 25 action research papers: (1) "Reading and Writing": A Study Comparing the Strengths of Peer Review and Visible Author Writing Strategies (Elizabeth Behar); (2)…

Studies in Teaching: 2016 Research Digest. Action Research Projects Presented at Annual Research Forum (Winston-Salem, North Carolina, Jun 30, 2016)

ERIC Educational Resources Information Center

McCoy, Leah P., Ed.

2016-01-01

This document presents the proceedings of the 21st Annual Research Forum held June 30, 2016, at Wake Forest University in Winston-Salem, North Carolina. Included are the following 11 action research papers: The Use of Mexican Folk Art to Develop Oral and Written Language Ability and Cultural Awareness in the Secondary Spanish Classroom (Antonio…

Dopaminergic modulation of effort-related choice behavior as assessed by a progressive ratio chow feeding choice task: pharmacological studies and the role of individual differences.

PubMed

Randall, Patrick A; Pardo, Marta; Nunes, Eric J; López Cruz, Laura; Vemuri, V Kiran; Makriyannis, Alex; Baqi, Younis; Müller, Christa E; Correa, Mercè; Salamone, John D

2012-01-01

Mesolimbic dopamine (DA) is involved in behavioral activation and effort-related processes. Rats with impaired DA transmission reallocate their instrumental behavior away from food-reinforced tasks with high response requirements, and instead select less effortful food-seeking behaviors. In the present study, the effects of several drug treatments were assessed using a progressive ratio (PROG)/chow feeding concurrent choice task. With this task, rats can lever press on a PROG schedule reinforced by a preferred high-carbohydrate food pellet, or alternatively approach and consume the less-preferred but concurrently available laboratory chow. Rats pass through each ratio level 15 times, after which the ratio requirement is incremented by one additional response. The DA D(2) antagonist haloperidol (0.025-0.1 mg/kg) reduced number of lever presses and highest ratio achieved but did not reduce chow intake. In contrast, the adenosine A(2A) antagonist MSX-3 increased lever presses and highest ratio achieved, but decreased chow consumption. The cannabinoid CB1 inverse agonist and putative appetite suppressant AM251 decreased lever presses, highest ratio achieved, and chow intake; this effect was similar to that produced by pre-feeding. Furthermore, DA-related signal transduction activity (pDARPP-32(Thr34) expression) was greater in nucleus accumbens core of high responders (rats with high lever pressing output) compared to low responders. Thus, the effects of DA antagonism differed greatly from those produced by pre-feeding or reduced CB1 transmission, and it appears unlikely that haloperidol reduces PROG responding because of a general reduction in primary food motivation or the unconditioned reinforcing properties of food. Furthermore, accumbens core signal transduction activity is related to individual differences in work output.

Studies in Teaching: 2015 Research Digest. Action Research Projects Presented at Annual Research Forum (Winston-Salem, North Carolina, June 25, 2015)

ERIC Educational Resources Information Center

McCoy, Leah P., Ed.

2015-01-01

This document presents the proceedings of the 20th Annual Research Forum held June 25, 2015, at Wake Forest University in Winston-Salem, North Carolina. Included are the following 21 action research papers: (1) History Lives! The Use of Simulations in a High School Social Studies Classroom (Lydia Adkins); (2) Using Francophone Music in the High…

SU-E-CAMPUS-T-01: Automation of the Winston-Lutz Test for Stereotactic Radiosurgery

DOE Office of Scientific and Technical Information (OSTI.GOV)

Litzenberg, D; Irrer, J; Kessler, M

Purpose: To optimize clinical efficiency and shorten patient wait time by minimizing the time and effort required to perform the Winston-Lutz test before stereotactic radiosurgery (SRS) through automation of the delivery, analysis, and documentation of results. Methods: The radiation fields of the Winston-Lutz (WL) test were created in a “machine-QA patient” saved in ARIA for use before SRS cases. Images of the BRW target ball placed at mechanical isocenter are captured with the portal imager for each of four, 2cm×2cm, MLC-shaped beams. When the WL plan is delivered and closed, this event is detected by in-house software called EventNet whichmore » automates subsequent processes with the aid of the ARIA web services. Images are automatically retrieved from the ARIA database and analyzed to determine the offset of the target ball from radiation isocenter. The results are posted to a website and a composite summary image of the results is pushed back into ImageBrowser for review and authenticated documentation. Results: The total time to perform the test was reduced from 20-25 minutes to less than 4 minutes. The results were found to be more accurate and consistent than the previous method which used radiochromic film. The images were also analyzed with DoseLab for comparison. The difference between the film and automated WL results in the X and Y direction and the radius were (−0.17 +/− 0.28) mm, (0.21 +/− 0.20) mm and (−0.14 +/− 0.27) mm, respectively. The difference between the DoseLab and automated WL results were (−0.05 +/− 0.06) mm, (−0.01 +/− 0.02) mm and (0.01 +/− 0.07) mm, respectively. Conclusions: This process reduced patient wait times by 15–20 minutes making the treatment machine available to treat another patient. Accuracy and consistency of results were improved over the previous method and were comparable to other commercial solutions. Access to the ARIA web services is made possible through an Eclipse co

Exposure to excess insulin (glargine) induces type 2 diabetes mellitus in mice fed on a chow diet.

PubMed

Yang, Xuefeng; Mei, Shuang; Gu, Haihua; Guo, Huailan; Zha, Longying; Cai, Junwei; Li, Xuefeng; Liu, Zhenqi; Cao, Wenhong

2014-06-01

We have previously shown that insulin plays an important role in the nutrient-induced insulin resistance. In this study, we tested the hypothesis that chronic exposure to excess long-acting insulin (glargine) can cause typical type 2 diabetes mellitus (T2DM) in normal mice fed on a chow diet. C57BL/6 mice were treated with glargine once a day for 8 weeks, followed by evaluations of food intake, body weight, blood levels of glucose, insulin, lipids, and cytokines, insulin signaling, histology of pancreas, ectopic fat accumulation, oxidative stress level, and cholesterol content in mitochondria in tissues. Cholesterol content in mitochondria and its association with oxidative stress in cultured hepatocytes and β-cells were also examined. Results show that chronic exposure to glargine caused insulin resistance, hyperinsulinemia, and relative insulin deficiency (T2DM). Treatment with excess glargine led to loss of pancreatic islets, ectopic fat accumulation in liver, oxidative stress in liver and pancreas, and increased cholesterol content in mitochondria of liver and pancreas. Prolonged exposure of cultured primary hepatocytes and HIT-TI5 β-cells to insulin induced oxidative stress in a cholesterol synthesis-dependent manner. Together, our results show that chronic exposure to excess insulin can induce typical T2DM in normal mice fed on a chow diet. © 2014 The authors.

Improving health care through evaluation research: an interview with Katherine Nelson by Pamela J Wood and Lynne S Giddings.

PubMed

Nelson, Katherine

2006-11-01

Proposals for establishing or changing health care services are increasingly expected to include a framework for evaluating their delivery and effectiveness. Evaluation research in health care is therefore a rapidly developing area. It is crucial that nurses understand how to use this methodology effectively so they can make a case for the establishment, continuation or expansion of a health service and improve existing ones. This article describes aspects of evaluation research as interpreted by Katherine Nelson (RN, MA, PhD) in interview. It is the sixteenth article in a series based on interviews with nursing and midwifery researchers, and is primarily designed to offer the new researcher a first-hand account of the experience of using research methodologies. Kathy is a lecturer in the Graduate School of Nursing, Midwifery & Health at Victoria University of Wellington. She has undertaken several research projects evaluating different health care programmes.

Expression of aquaporins in the efferent ductules, sperm counts, and sperm motility in estrogen receptor-alpha deficient mice fed lab chow versus casein.

PubMed

Ruz, Ricardo; Gregory, Mary; Smith, Charles E; Cyr, Daniel G; Lubahn, Dennis B; Hess, Rex A; Hermo, Louis

2006-02-01

Estrogens play an important role in the male reproductive tract, and this is especially so for the efferent ductules, where alpha-estrogen receptors (ERalpha) have been localized. Mice deficient in ERalpha (alphaERKO mice) are infertile, and the effect appears to be due in part to retention of water at the level of the efferent ductules. In the present study, we examined the consequences of ERalpha deletion on the distribution of certain aquaporins (AQPs), water protein channels, in the efferent ductules and on sperm numbers and motility. In addition, the effects of feeding mice a regular lab chow diet, which contains phytoestrogens, known to affect male reproductive tract functions, and a casein diet, which lacks phytoestrogens, were also assessed. Light microscope immunolocalizations of AQP-1 and AQP-9 revealed dramatic reduction and patchier staining in alphaERKO mice with distal areas of the efferent ductules being more affected than proximal areas. No other changes in immunolocalizations were noted as a consequence of diet. Computer-assisted sperm analyses demonstrated a 62% reduction in cauda epididymal sperm/ml in alphaERKO mice fed lab chow, whereas 87% fewer sperm/ml were observed in alphaERKO mice fed casein, suggesting an enhanced role for sperm production and concentration in a diet containing phytoestrogens. All sperm motility parameters were altered to some degree in alphaERKO mice fed lab chow. Alterations in sperm motility parameters were also detected, but were less dramatic in alphaERKO mice fed casein. These data suggest that the decrease in AQP expression in the efferent ductules of alphaERKO mice contributes in part to water retention in this tissue, eventually leading to backflow of water into the testis, with subsequent decreases in sperm concentration and motility. The data also suggest that phytoestrogens, which are present in regular lab chow, can influence the male reproductive tract with and without the presence of ERalpha, promoting

Seroprevalence of HCV and HIV infection among clients of the nation's longest-standing statewide syringe exchange program: A cross-sectional study of Community Health Outreach Work to Prevent AIDS (CHOW).

PubMed

Salek, Thomas P; Katz, Alan R; Lenze, Stacy M; Lusk, Heather M; Li, Dongmei; Des Jarlais, Don C

2017-10-01

The Community Health Outreach Work to Prevent AIDS (CHOW) Project is the first and longest-standing statewide integrated and funded needle and syringe exchange program (SEP) in the US. Initiated on O'ahu in 1990, CHOW expanded statewide in 1993. The purpose of this study is to estimate the prevalences of hepatitis C virus (HCV) and human immunodeficiency virus (HIV) infection, and to characterize risk behaviors associated with infection among clients of a long-standing SEP through the analysis of the 2012 CHOW evaluation data. A cross-sectional sample of 130 CHOW Project clients was selected from January 1, 2012 through December 31, 2012. Questionnaires captured self-reported exposure information. HIV and HCV antibodies were detected via rapid, point-of-care FDA-approved tests. Log-binomial regressions were used to estimate prevalence proportion ratios (PPRs). A piecewise linear log-binomial regression model containing 1 spline knot was used to fit the age-HCV relationship. The estimated seroprevalence of HCV was 67.7% (95% confidence interval [CI]=59.5-75.8%). HIV seroprevalence was 2.3% (95% CI=0-4.9%). Anti-HCV prevalence demonstrated age-specific patterns, ranging from 31.6% through 90.9% in people who inject drugs (PWID) <30 to ≥60 years respectively. Age (continuous/year) prior to spline knot at 51.5 years (adjusted PPR [APPR]=1.03; 95% CI=1.02-1.05) and months exchanging syringes (quartiles) (APPR=1.92; 95% CI=1.3-3.29) were independently associated with anti-HCV prevalence. In Hawai'i, HCV prevalence among PWID is hyperendemic demonstrating age- and SEP duration-specific trends. Relatively low HIV prevalence compared with HCV prevalence reflects differences in transmissibility of these 2 blood-borne pathogens and suggests much greater efficacy of SEP for HIV prevention. Copyright © 2017 Elsevier B.V. All rights reserved.

The monoamine-oxidase B inhibitor deprenyl increases selection of high-effort activity in rats tested on a progressive ratio/chow feeding choice procedure: Implications for treating motivational dysfunctions.

PubMed

Yohn, Samantha E; Reynolds, Shanika; Tripodi, Giuseppe; Correa, Merce; Salamone, John D

2018-04-16

Motivated behaviors often are characterized by a high degree of behavioral activation and work output, and organisms frequently make effort-related decisions based upon cost/benefit analyses. Moreover, people with depression and other disorders frequently show effort-related motivational symptoms, such as anergia, psychomotor retardation, and fatigue. Tasks measuring effort-related choice are being used as animal models of these motivational symptoms. The present studies characterized the ability of the monoamine oxidase -B (MAO-B) inhibitor deprenyl (selegiline) to enhance selection of high-effort lever pressing in rats tested on a concurrent progressive ratio (PROG)/chow feeding choice task. Deprenyl is widely used as an antiparkinsonian drug, but it also has been shown to have antidepressant effects in humans, and to induce antidepressant-like effects in traditional rodent models of depression. Systemic administration of deprenyl (1.5-12.0 mg/kg IP) shifted choice behavior, significantly increasing markers of PROG lever pressing at a moderate dose (6.0 mg/kg), and decreasing chow intake at 6.0 and 12.0 mg/kg. Intracranial injections of deprenyl into nucleus accumbens (2.0 and 4.0 μg) also increased PROG lever pressing and decreased chow intake. Microdialysis studies showed that the dose of deprenyl that was effective at increasing PROG lever pressing (6.0 mg/kg) also significantly elevated extracellular dopamine in nucleus accumbens. Thus, similar to the well-known antidepressant bupropion, deprenyl is capable of increasing selection of high-effort PROG lever pressing at doses that increase extracellular dopamine in nucleus accumbens. These studies have implications for the potential use of MAO-B inhibitors as treatments for the motivational symptoms of depression and Parkinsonism. Copyright © 2018 Elsevier B.V. All rights reserved.

Bromocriptine increased operant responding for high fat food but decreased chow intake in both obesity-prone and resistant rats

DOE Office of Scientific and Technical Information (OSTI.GOV)

Thanos, P.K.; Wang, G.; Thanos, P.K.

Dopamine (DA) and DAD{sub 2} receptors (D2R) have been implicated in obesity and are thought to be involved in the rewarding properties of food. Osborne-Mendel (OM) rats are susceptible to diet induced obesity (DIO) while S5B/P (S5B) rats are resistant when given a high-fat diet. Here we hypothesized that the two strains would differ in high-fat food self-administration (FSA) and that the D2R agonist bromocriptine (BC) would differently affect their behavior. Ad-libitum fed OM and S5B/P rats were tested in a FSA operant chamber and were trained to lever press for high-fat food pellets under a fixed-ratio (FR1) and amore » progressive ratio (PR) schedule. After sixteen days of PR sessions, rats were treated with three different doses of BC (1, 10 and 20 mg/kg). No significant differences were found between the two strains in the number of active lever presses. BC treatment (10 mg/kg and 20 mg/kg) increased the number of active lever presses (10 mg/kg having the strongest effect) whereas it decreased rat chow intake in the home cage with equivalent effects in both strains. These effects were not observed on the day of BC administration but on the day following its administration. Our results suggest that these two strains have similar motivation for procuring high fat food using this paradigm. BC increased operant responding for high-fat pellets but decreased chow intake in both strains, suggesting that D2R stimulation may have enhanced the motivational drive to procure the fatty food while correspondingly decreasing the intake of regular food. These findings suggest that susceptibility to dietary obesity (prior to the onset of obesity) may not affect operant motivation for a palatable high fat food and that differential susceptibility to obesity may be related to differential sensitivity to D2R stimulation.« less

Organochlorine accumulation by Sentinel Mallards at the Winston-Thomas sewage treatment plant, Bloomington, Indiana

USGS Publications Warehouse

Custer, T.W.; Sparks, D.W.; Sobiech, S.A.; Hines, R.K.; Melancon, M.J.

1996-01-01

Farm-raised l2-month-old female mallards (Anas platyrhynchos) were released at the Winston-Thomas sewage treatment plant, Bloomington, Indiana. Five mallards were sacrificed at the start of the study and at approximately 10-day intervals through day 100. Concentrations of polychlorinated biphenyls (PCBs) in carcasses increased linearly with time of exposure and exceeded 16 mcg/g wet weight by day 100; PCBs in breast muscle exceeded 3.9 mcg/g by day 100. These PCB values are among the highest recorded for wild or sentinel waterfowl. PCB concentrations in breast muscle (26-523 mcg/g lipid weight) were 50-1,000 times greater than human consumption guidelines for edible poultry in Canada (0.5 mcg/g lipid weight) and 9-176 times greater than consumption guidelines for edible poultry in the United States (3.0 mcg/g lipid weight). Additionally, PCB concentrations in carcass and breast muscle exceeded the threshold of the Great Lakes Sport Fish Consumption Advisory 'do not eat' category (1.9 mcg/g wet weight) by day 20 and day 50, respectively. Hepatic cytochrome P450-associated monooxygenases including BROD (benzyloxyresorufin-O-dealkylase), EROD (ethoxyresorufin-O-dealkylase), and PROD (pentoxyresorufin-O-dealkylase) were induced over 5-fold compared to reference mallards. BROD, EROD, and PROD were each significantly correlated to total PCBs and to the toxicity of selected PCB congeners, relative to 2,3,7,8-tetrachlorodibenzo-p-dioxin.

Organochlorine accumulation by sentinel mallards at the Winston-Thomas sewage treatment plant, Bloomington, Indiana

USGS Publications Warehouse

Custer, T.W.; Sparks, D.W.; Sobiech, S.A.; Hines, R.K.; Melancon, M.J.

1996-01-01

Farm-raised 12-month-old female mallards (Anas platyrhynchos) were released at the Winston-Thomas sewage treatment plant, Bloomington, Indiana. Five mallards were sacrificed at the start of the study and at approximately 10-day intervals through day 100. Concentrations of polychlorinated biphenyls (PCBs) in carcasses increased linearly with time of exposure and exceeded 16 g/g wet weight by day 100; PCBs in breast muscle exceeded 3.9 g/g by day 100. These PCB values are among the highest recorded for wild or sentinel waterfowl. PCB concentrations in breast muscle (26a??523 g/g lipid weight) were 50a??1,000 times greater than human consumption guidelines for edible poultry in Canada (0.5 g/g lipid weight) and 9a??176 times greater than consumption guidelines for edible poultry in the United States (3.0 g/g lipid weight). Additionally, PCB concentrations in carcass and breast muscle exceeded the threshold of the Great Lakes Sport Fish Consumption Advisory do not eat category (1.9 g/g wet weight) by day 20 and day 50, respectively. Hepatic cytochrome P450-associated monooxygenases including BROD (benzyloxyresorufin-O-dealkylase), EROD (ethoxyresorufin-O-dealkylase), and PROD (pentoxyresorufin-O-dealkylase) were induced over 5-fold compared to reference mallards. BROD, EROD, and PROD were each significantly correlated to total PCBs and to the toxicity of selected PCB congeners, relative to 2,3,7,8-tetrachlorodibenzo-p-dioxin.

Endoscopic carpal tunnel release using the modified Chow's extrabursal dual portal technique: clinical results of 640 patients.

PubMed

Kim, Poong-Taek; Micić, Ivan D; Park, Il-Hyng; Jeon, In-ho

2007-01-01

During a 4-year period, a total of 784 wrists of 640 patients were treated using a modified Chow's extrabursal dual portal endoscopic technique. All surgeries were performed under local anesthesia. A 1-cm incision was marked 1-2 cm proximal to the distal wrist crease, in the midline, ulnar to the palmaris longus. A distal portal was established along a line bisecting an angle created by the intersection of the ulnar border of the abducted thumb and the third web space. An obturator and cannula assembly were inserted under the portal, and three blades were used to cut under endoscopic vision. Subjective results showed that 706 hands (90%) had a reduction in the severity of pain after carpal tunnel release, 706 hands (90%) had a reduction in the severity of paresthesia and 729 hands (93%) had a reduction in the severity of numbness. Nocturnal pain and paresthesia were relieved in 745 cases (95%). Compared with the conventional open carpal tunnel release, less postoperative pain and faster recovery have been reported following endoscopic carpal tunnel release. This study suggests that extrabursal dual portal technique is a safe and reliable treatment option for carpal tunnel syndrome with a high success rate.

News Particle Physics: ATLAS unveils mural at CERN Prize: Corti Trust invites essay entries Astrophysics: CERN holds cosmic-ray conference Researchers in Residence: Lord Winston returns to school Music: ATLAS scientists record physics music Conference: Champagne flows at Reims event Competition: Students triumph at physics olympiad Teaching: Physics proves popular in Japanese schools Forthcoming Events

NASA Astrophysics Data System (ADS)

2011-01-01

Particle Physics: ATLAS unveils mural at CERN Prize: Corti Trust invites essay entries Astrophysics: CERN holds cosmic-ray conference Researchers in Residence: Lord Winston returns to school Music: ATLAS scientists record physics music Conference: Champagne flows at Reims event Competition: Students triumph at physics olympiad Teaching: Physics proves popular in Japanese schools Forthcoming Events

SU-E-J-117: Verification Method for the Detection Accuracy of Automatic Winston Lutz Test

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tang, A; Chan, K; Fee, F

2014-06-01

Purpose: Winston Lutz test (WLT) has been a standard QA procedure performed prior to SRS treatment, to verify the mechanical iso-center setup accuracy upon different Gantry/Couch movements. Several detection algorithms exist,for analyzing the ball-radiation field alignment automatically. However, the accuracy of these algorithms have not been fully addressed. Here, we reveal the possible errors arise from each step in WLT, and verify the software detection accuracy with the Rectilinear Phantom Pointer (RLPP), a tool commonly used for aligning treatment plan coordinate with mechanical iso-center. Methods: WLT was performed with the radio-opaque ball mounted on a MIS and irradiated onto EDR2more » films. The films were scanned and processed with an in-house Matlab program for automatic iso-center detection. Tests were also performed to identify the errors arise from setup, film development and scanning process. The radioopaque ball was then mounted onto the RLPP, and offset laterally and longitudinally in 7 known positions ( 0, ±0.2, ±0.5, ±0.8 mm) manually for irradiations. The gantry and couch was set to zero degree for all irradiation. The same scanned images were processed repeatedly to check the repeatability of the software. Results: Miminal discrepancies (mean=0.05mm) were detected with 2 films overlapped and irradiated but developed separately. This reveals the error arise from film processor and scanner alone. Maximum setup errors were found to be around 0.2mm, by analyzing data collected from 10 irradiations over 2 months. For the known shift introduced using the RLPP, the results agree with the manual offset, and fit linearly (R{sup 2}>0.99) when plotted relative to the first ball with zero shift. Conclusion: We systematically reveal the possible errors arise from each step in WLT, and introduce a simple method to verify the detection accuracy of our in-house software using a clinically available tool.« less

Katherine Hurst | NREL

Science.gov Websites

, followed by the completion of a M.S. in Chemical Engineering from the Colorado School of Mines. She received her Ph.D. in Chemical Engineering. Her thesis, which was performed at NREL under the direction of 2001-2005 Ph.D. Chemical Engineering, Colorado School of Mines, Golden, CO Research Fellowship at the

Katherine Dykes | NREL

Science.gov Websites

Smarter Cities Marketing Insights 2.0 initiative, a data quality analyst at EnerNOC for its demand wind energy as a wind program analyst for Green Energy Ohio in 2005 and as a data analyst for The

On the selection of gantry and collimator angles for isocenter localization using Winston-Lutz tests.

PubMed

Du, Weiliang; Johnson, Jennifer L; Jiang, Wei; Kudchadker, Rajat J

2016-01-08

In Winston-Lutz (WL) tests, the isocenter of a linear accelerator (linac) is determined as the intersection of radiation central axes (CAX) from multiple gantry, collimator, and couch angles. It is well known that the CAX can wobble due to mechanical imperfections of the linac. Previous studies suggested that the wobble varies with gantry and collimator angles. Therefore, the isocenter determined in the WL tests has a profound dependence on the gantry and collimator angles at which CAX are sampled. In this study, we evaluated the systematic and random errors in the iso-centers determined with different CAX sampling schemes. Digital WL tests were performed on six linacs. For each WL test, 63 CAX were sampled at nine gantry angles and seven collimator angles. Subsets of these data were used to simulate the effects of various CAX sampling schemes. An isocenter was calculated from each subset of CAX and compared against the reference isocenter, which was calculated from 48 opposing CAX. The differences between the calculated isocenters and the reference isocenters ranged from 0 to 0.8 mm. The differences diminished to less than 0.2 mm when 24 or more CAX were sampled. Isocenters determined with collimator 0° were vertically lower than those determined with collimator 90° and 270°. Isocenter localization errors in the longitudinal direction (along the axis of gantry rotation) showed a strong dependence on the collimator angle selected. The errors in all directions were significantly reduced when opposing collimator angles and opposing gantry angles were employed. The isocenter localization errors were less than 0.2 mm with the common CAX sampling scheme, which used four cardinal gantry angles and two opposing collimator angles. Reproducibility stud-ies on one linac showed that the mean and maximum variations of CAX during the WL tests were 0.053 mm and 0.30 mm, respectively. The maximal variation in the resulting isocenters was 0.068 mm if 48 CAX were used, or 0

Hearings Before the Special Subcommittee on Education of the Committee on Education and Labor, House of Representatives, Ninety-third Congress, First Session on H.R. 1144, H.R. 2994, H.R. 7261, H.R. 9065, H.R. 9960, H.R. 10027, H.R. 11658, and S. 1418. Bills to Provide Grants to Eisenhower College, Deganawidah-Quetzalcoatl University, the Sam Rayburn Library, the Winston Churchill Memorial Library, and the Hoover Institution on War, Revolution, and Peace.

ERIC Educational Resources Information Center

Congress of the U.S., Washington, DC. House Committee on Education and Labor.

This document presents hearings before the special subcommittee on Education of the Committee on Education and Labor, House of Representatives, 93rd Congress concerning the provision of grants to Eisenhower College, Deganawidah-Quetzalcoatl University, the Sam Rayburn Library, the Winston Churchill Library, and the Hoover Institute on War,…

75 FR 40760 - Approval and Promulgation of Air Quality Implementation Plans; Illinois; Volatile Organic...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-14

... recordkeeping procedures in Katherine Hodge's April 23, 2008 email to EPA, including both the body of the email... recordkeeping requirements reflected in Katherine Hodge's April 23, 2008 email, including both the body of the e...

Differential effects of habitual chow-based and semi-purified diets on lipid metabolism in lactating rats and their offspring.

PubMed

Del Bas, Josep Maria; Caimari, Antoni; Ceresi, Enzo; Arola-Arnal, Anna; Palou, Andreu; Arola, Lluís; Crescenti, Anna

2015-03-14

Diet during pregnancy and lactation is a critical factor in relation to the health of dams and their offspring. Currently, control diets used in metabolic imprinting studies differ in composition and type, i.e. semi-purified diets (SD) or chow-based diets (ND). The aim of the present study was to determine whether two widely used control diets, a SD and a ND, that mainly differ in fat content (5·08 and 3·26 %, respectively) and its sources (soyabean oil for the SD and cereals and fish for the ND), fibre (6 and 15 %, respectively), and cholesterol (26 and 69 mg/kg diet, respectively) can influence the lipid metabolism of dams and their offspring. Wistar rats were fed either the SD or the ND during pregnancy and lactation. At weaning, SD-fed dams presented severe hepatic steatosis and increased levels of circulating TAG, NEFA and insulin. Importantly, the offspring presented an altered plasma lipid profile. In contrast, the ND allowed for a normal gestation and lactation process, and did not affect the metabolism of offspring. In parallel, virgin rats fed the SD showed no metabolic alterations. A higher intake of SFA and MUFA and a lower consumption of PUFA observed in SD-fed dams during the lactation period could contribute to explaining the observed effects. In conclusion, two different control diets produced very different outcomes in the lipid metabolism of lactating rats and their offspring. The present results highlight the importance of the assessment of the metabolic state of dams when interpreting the results of metabolic programming studies.

75 FR 57825 - Culturally Significant Objects Imported for Exhibition Determinations: “Ancient Chinese Bronzes...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-22

... DEPARTMENT OF STATE [Public Notice 7181] Culturally Significant Objects Imported for Exhibition Determinations: ``Ancient Chinese Bronzes From the Shouyang Studio: The Katherine and George Fan Collection... ``Ancient Chinese Bronzes from the Shouyang Studio: The Katherine and George Fan Collection,'' imported from...

77 FR 25366 - Underground Storage Tank Program: Approved State Program for the State of Oregon

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-30

... the online instructions for submitting comments. Email: griffith[email protected] . Mail: Katherine Griffith, U. S. Environmental Protection Agency, Region 10, 1200 Sixth Avenue, Suite 900, Mail Stop: OCE... electronically in http://www.regulations.gov or in hard copy. FOR FURTHER INFORMATION CONTACT: Katherine Griffith...

Altered Body Weight Regulation in CK1ε Null and tau Mutant Mice on Regular Chow and High Fat Diets

PubMed Central

Zhou, Lili; Summa, Keith C.; Olker, Christopher; Vitaterna, Martha H.; Turek, Fred W.

2016-01-01

Disruption of circadian rhythms results in metabolic dysfunction. Casein kinase 1 epsilon (CK1ε) is a canonical circadian clock gene. Null and tau mutations in CK1ε show distinct effects on circadian period. To investigate the role of CK1ε in body weight regulation under both regular chow (RC) and high fat (HF) diet conditions, we examined body weight on both RC and HF diets in CK1ε −/− and CK1ε tau/tau mice on a standard 24 hr light-dark (LD) cycle. Given the abnormal entrainment of CK1ε tau/tau mice on a 24 hr LD cycle, a separate set of CK1ε tau/tau mice were tested under both diet conditions on a 20 hr LD cycle, which more closely matches their endogenous period length. On the RC diet, both CK1ε −/− and CK1ε tau/tau mutants on a 24 hr LD cycle and CK1ε tau/tau mice on a 20 hr LD cycle exhibited significantly lower body weights, despite similar overall food intake and activity levels. On the HF diet, CK1ε tau/tau mice on a 20 hr LD cycle were protected against the development of HF diet-induced excess weight gain. These results provide additional evidence supporting a link between circadian rhythms and energy regulation at the genetic level, particularly highlighting CK1ε involved in the integration of circadian biology and metabolic physiology. PMID:27144030

Understanding and Responding to Persistently High Unemployment

DTIC Science & Technology

2012-02-01

Reserve Bank of San Francisco, September 2011), www.frbsf.org/ publications/economics/papers/2011/wp11-05bk.pdf. 21. See Rob Valletta and Katherine Kuang...is 30. See Robert Valletta and Katherine Kuang, Extended Unemployment and UI Benefits, Economic Letter 2010-12 (Federal Reserve Bank of San

Thank You, Miss Katherine

ERIC Educational Resources Information Center

Compton, Cynthia

2008-01-01

Richmond Ballet's Mind in Motion program offers selected students an opportunity to take group dance lessons during 4th grade. Time taken away from academic instruction did not have a negative effect on standardized test scores and students reported feelings of greater success in school, more focus on school work, and greater ability to work with…

40 CFR 52.934 - VOC rule deficiency correction.

Code of Federal Regulations, 2010 CFR

2010-07-01

... letter from Winston A. Smith, Air, Pesticides & Toxics Management Division Director, to William C. Eddins..., and clarified in a letter from Winston A. Smith, Air, Pesticides & Toxics Management Division Director...

Prostate Cancer Research Training Program

DTIC Science & Technology

2009-02-01

Bukola Fatunmbi Katherine Foster Theon Francis Michelle Gray Julia Greenfield Gladys Murage Britanny Stokes Stacy-Ann Wright Lubaroff...Julia Greenfield 2008 Henry Lincoln junior Gladys Murage 2008 Domann Lincoln senior Brittany Stokes 2008 Griffith Lincoln senior Stacy-Ann Wright...report; page 10 Bukola Fatunmbi Katherine Foster Theon Francis Michelle Gray Julia Greenfield Gladys Murage Iowa/Lincoln Summer Research Training

75 FR 28590 - Procurement List Additions

Federal Register 2010, 2011, 2012, 2013, 2014

2010-05-21

... Container. NPA: Winston-Salem Industries for the Blind, Winston-Salem, NC. Contracting Activity: DEPT OF THE... DEPT OF THE ARMY, ACA NATICK, Natick, MA. Tape, Insulation, Electrical NSN: 5970-00-240-0617. NSN: 5970...

Prostate Cancer Research Training Program

DTIC Science & Technology

2009-06-01

Katherine Foster Theon Francis Michelle Gray Julia Greenfield Gladys Murage Brittany Stokes Stacy-Ann Wright Students Accepted for the 2009...graduate school Michelle Gray 2008 Lubaroff U. Mass Graduate Julia Greenfield 2008 Henry Lincoln Senior Gladys Murage 2008 Domann U. Mass Graduate...Bukola Fatumnbi Michelle Gray 2009 Lincoln Students at the University of Iowa Julia Greenfield Katherine Foster Gladys Murage Stacy-Ann Wright

77 FR 2048 - Procurement List Proposed Additions

Federal Register 2010, 2011, 2012, 2013, 2014

2012-01-13

..., Vandenberg AFB, CA. Service Type/Location: Base Supply Center, National Maritime Intelligence Center/Office of Naval Intelligence, 4251 Suitland Road, Suitland, MD. NPA: Winston-Salem Industries for the Blind, Inc., Winston-Salem, NC. Contracting Activity: Dept. of the Navy, Office of Naval Intelligence...

75 FR 14575 - Procurement List; Proposed Additions

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-26

... Cost Container. NPA: Winston-Salem Industries for the Blind, Winston-Salem, NC. Contracting Activity... the Department of the Army, Natick, MA. Tape, Insulation, Electrical NSN: 5970-00-240-0617. NSN: 5970... Base, Warner Robins, GA. NPA: Georgia Industries for the Blind, Bainbridge, GA. Contracting Activity...

United States Air Force Summer Research Program -- 1993 Summer Research Program Final Reports. Volume 12. Armstrong Laboratory

DTIC Science & Technology

1993-01-01

Panasonic TLD . Panasonic Industrial Company; Secaucus, New Jersey. 5. Thurlow, Ronald M. "Neutron Dosimetry Using a Panasonic Thermoluminescent Dosimeter." A...steps 8-12. 29-15 THE BUILDING OF THE USAF PANASONIC UD-809AS ALGORITHM Katherine M. Arnold Research Associate Radiation Dosimetry Branch Brooks Air...Research August 1993 30-1 THE BUILDING OF THE USAF PANASONIC UD-809AS ALGORITHM Katherine M. Arnold Research Associate Radiation Dosimetry Branch

75 FR 60778 - Announcement of Funding Awards for Fiscal Year 2010 Historically Black Colleges and Universities...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-01

..., and Grant Amount Region IV 1. Winston-Salem State University, Ms. Valerie Howard, Winston Salem State... Awards for Fiscal Year 2010 Historically Black Colleges and Universities Program AGENCY: Office of the... Historically Black Colleges and Universities Program. The purpose of this document is to announce the names...

Katherine Young, P.E. | NREL

Science.gov Websites

) Water rights and resources engineering Database planning and development Research Interests Collection lean principles to streamline exploration and drilling and reduce error/risk Research, development and Groundwater modeling Quantitative methods in water resource engineering Water resource engineering and

Community Based Training Centers for the Vocational Transitioning of Students with Mental Retardation.

ERIC Educational Resources Information Center

Craft, Robert D.; Martch, Theodore

The Douglas Education Service District, Winston Dillard School District, and the Special Education Department at Douglas High School in Winston, Oregon, developed a community-based education program that emphasizes ongoing job training for students with mental disabilities and the development of competitive employment in the community. The program…

Airport Activity Statistics of Certificated Route Air Carriers.

DTIC Science & Technology

1985-12-31

Houlton, ME............ Presque Isle /Houlton Bluefield, WV........... Princeon/Bhzefield Huntington, WV......... Ashland/ Huntington Bonn, Germany...Benito Wheeling, WV ......... Pttaburgh/ Wheeling (Under Pennsylvania ) San Bernardino, CA ... Ontario & San Bernardino White River Junction, VT... Pennsylvania ) Spartanburg, SC........ Greenville/Spartanbury Winston-Salem, NC ... Greensboro/High Point/Winston-Salem Springfield, MA......... Hartford

75 FR 76039 - LF USA, Inc., a Subsidiary of Li & Fung Limited, Including Workers Whose Unemployment Insurance...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-07

... Through Wear Me Apparel LLC, Including On-Site Leased Workers From Winston Staffing, Laurinburg, NC... under a separate unemployment insurance (UI) tax account under the name Wear Me Apparel LLC. Accordingly... insurance (UI) wages are reported through Wear Me Apparel LLC, including on-site leased workers from Winston...

My Lovely C-Section

PubMed Central

Taylor, Katherine

2010-01-01

Katherine and Andrew Taylor chose to have a planned home birth. With the support of her husband, Andrew, and her midwife and doula, Katherine labored at home for 48 hours before transferring to the hospital. Baby Luke was born by cesarean about 20 hours later. Confident and supported, the Taylors were able to make informed decisions and have a positive birth experience, although it was not what they had planned. PMID:21358828

Factors that Influence Physician Identification of Potential Opioid Misusers

DTIC Science & Technology

2013-05-30

Shawn M. FWI-l20120134E Mannina, Lisa M. Bebarta, Vikhyat S. oe. I ,o.;:,l\\ 1\\IUIVIUI:ti Ganem, Victoria J. Carey , Katherine R. or. VVUHI\\ Ul\\111 1...opioid misusers Lisa M. Manina, Shawn M. Varney, Vikhyat S. Bebarta, Katherine R. Carey , Victoria J. Ganem, Rosemarie G. Ramos Background...Varney SM, Bebarta VS, Carey KR, Ganem VJ, Ramos RG Department of Emergency Medicine, San Antonio Military Medical Center, San Antonio, TX

CHOW PARAMETERS IN THRESHOLD LOGIC,

DTIC Science & Technology

respect to threshold functions, they provide the optimal test-synthesis method for completely specified 7-argument (or less) functions, reflect the...signs and relative magnitudes of realizing weights and threshold , and can be used themselves as approximating weights. Results are reproved in a

Corrigendum.

PubMed

2015-04-01

Corrigendum for 'GENETIC DIFFERENCES IN CYTOCHROME P450 ENZYMES AND ANTIDEPRESSANT TREATMENT RESPONSE' by: Karen Hodgson, Katherine Tansey, Mojca Zvezdana Dernovšek, Joanna Hauser, Neven Henigsberg, Wolfgang Maier, Ole Mors, Anna Placentino, Marcella Rietschel, Daniel Souery, Rebecca Smith, Ian W Craig, Anne E Farmer, Katherine J Aitchison, Sarah Belsey, Oliver SP Davis, Rudolf Uher, and Peter McGuffin. Journal of Psychopharmacology 28: 133-141. DOI: 10.1177/0269881113512041. The following author name Sarah Belsey was erroneously misspelled as Sarah Belsy. © The Author(s) 2015.

CRF-CRF1 receptor system in the central and basolateral nuclei of the amygdala differentially mediates excessive eating of palatable food.

PubMed

Iemolo, Attilio; Blasio, Angelo; St Cyr, Stephen A; Jiang, Fanny; Rice, Kenner C; Sabino, Valentina; Cottone, Pietro

2013-11-01

Highly palatable foods and dieting are major contributing factors for the development of compulsive eating in obesity and eating disorders. We previously demonstrated that intermittent access to palatable food results in corticotropin-releasing factor-1 (CRF1) receptor antagonist-reversible behaviors, which include excessive palatable food intake, hypophagia of regular chow, and anxiety-like behavior. However, the brain areas mediating these effects are still unknown. Male Wistar rats were either fed chow continuously for 7 days/week (Chow/Chow group), or fed chow intermittently 5 days/week, followed by a sucrose, palatable diet 2 days/week (Chow/Palatable group). Following chronic diet alternation, the effects of microinfusing the CRF1 receptor antagonist R121919 (0, 0.5, 1.5 μg/side) in the central nucleus of the amygdala (CeA), the basolateral nucleus of the amygdala (BlA), or the bed nucleus of the stria terminalis (BNST) were evaluated on excessive intake of the palatable diet, chow hypophagia, and anxiety-like behavior. Furthermore, CRF immunostaining was evaluated in the brain of diet cycled rats. Intra-CeA R121919 blocked both excessive palatable food intake and anxiety-like behavior in Chow/Palatable rats, without affecting chow hypophagia. Conversely, intra-BlA R121919 reduced the chow hypophagia in Chow/Palatable rats, without affecting excessive palatable food intake or anxiety-like behavior. Intra-BNST treatment had no effect. The treatments did not modify the behavior of Chow/Chow rats. Immunohistochemistry revealed an increased number of CRF-positive cells in CeA--but not in BlA or BNST--of Chow/Palatable rats, during both withdrawal and renewed access to the palatable diet, compared with controls. These results provide functional evidence that the CRF-CRF1 receptor system in CeA and BlA has a differential role in mediating maladaptive behaviors resulting from palatable diet cycling.

Obituary: Elizabeth Katherine Holmes, 1973-2004

NASA Astrophysics Data System (ADS)

Beichman, Charles Arnold

2004-12-01

Elizabeth (Beth) K. Holmes died suddenly in Pasadena on March 23, 2004, from the unexpected effects of a long-standing heart condition. She was 30 years old. At the moment of her passing, she was at her computer comparing her theoretical models on the effects of planets on the distribution of zodiacal dust with some of the first observations from the Spitzer Space Telescope. Born on June 24, 1973, in New York City, Beth was the only child of James and Barbara Holmes, who were respectively, a financial manager and a nurse and social worker. Undeterred by numerous treatments and operations to correct a congenital heart condition, Beth developed an interest in math and physics leading to her graduation from MIT in 1995 with a bachelor's degree in Physics. She entered the University of Florida shortly afterwards to begin her PhD studies under the direction of Stanley Dermott. Beth was particularly interested in the dynamics of interplanetary dust, and initially worked on secular perturbations of the zodiacal cloud: how the planets impose warping of the cloud, and how they can force the center of the cloud to be offset from the Sun. Despite the fact that Beth was primarily a theorist, she was keen to include some observing experience in her PhD education. She recently completed an observing program with Harold Butner at the Steward and Palomar Observatories looking for submillimeter and mid-infrared emission around nearby main-sequence stars - a signpost of planetary formation. The results were published last year in the Astronomical Journal. Beth's PhD thesis work, some results of which were recently published in the Astrophysical Journal, focused on dust originating in the Kuiper belt and how some of this dust is expected to be spatially structured due to resonant interactions with Neptune. This phenomenon may be quite common in other planetary systems, with recent images of Epsilon Eridani perhaps providing a prime example of a Kuiper disk analog. After graduating from Florida in 2002, Beth took up a National Research Council postdoctoral position at the Jet Propulsion Laboratory with Charles Beichman and T. Velusamy with the goal of applying her theoretical knowledge of zodiacal clouds to observations from the Spitzer Space telescope. In advance of the launch of Spitzer, Beth gathered detailed information on over 150 solar type stars and carefully planned a Spitzer observing program to detect faint zodiacal signals. While waiting through numerous launch delays, she prepared models of zodiacal clouds influenced by the presence of planets to be ready when Spitzer images of stars like Vega, Upsilon Andromedae, and Fomalhaut became available. These models were presented as talks and posters at a number of conferences. Her models were a critical part of the Early Release Observations of Fomalhaut and the subsequent Spitzer paper on the possibility that a Jovian-mass planet located approximately 40 AU from the star was responsible for the structures seen in the Fomalhaut disk. The Fomalhaut paper in the special Spitzer edition of the Astrophysical Journal is dedicated to Beth's memory. Beth was an enthusiastic and cheerful colleague who made friends everywhere she worked. In addition to developing friendships and collaborations at JPL, she became a valued member of the Spitzer/MIPS instrument team at the University of Arizona. She was active on the Committee on the Status of Women in Astronomy of the American Astronomical Society, publishing an article on "The Postdoc Perspective on the Women in Astronomy II Conference" in the January 2004 issue of STATUS, the CSWA magazine, and serving as an associate editor of that magazine. She was an inspiring role model for young women in science, befriending and mentoring a number of Caltech women undergraduates, as well as making numerous appearances in K-12 classrooms for science outreach. She pursued her love of plants (cactus in particular), cats and fish, spending her spare time lovingly tending her small garden. Her friends and colleagues will remember Beth for her scientific contributions, but also for her courage as we realize that she worked beside us completely unshadowed by the heart condition that would take her in so sudden and untimely a manner. We take solace in the knowledge that at the moment of her passing, she was pursuing her passion for astronomy, working among colleagues who valued her work and her friendship, that she had a supportive and loving family with parents on the East Coast and close relatives on the West Coast, and that in her fiancé, Todd Rope, she had found a kindred spirit.

New Concepts in Ionospheric Modification

DTIC Science & Technology

1987-04-01

lasers, Phys. Fluids, 26, 1688-1692, 1986. Welford, W.T., and R. Winston , The Optics of Nonimaging Concentrators , 200 pp., Academic, New York, 1978...tantalum target/reflector assembly. We now use the following relationship, which follows from the conservation of optical 6tendue [ Welford and Winston ...of existing data obtained during thruster firings on STS-3 and Spacelab-2. (’orisiderable optical and plasma data are immediately available for study

A Wave Theory for Non-Imaging Concentrators

DTIC Science & Technology

1992-04-01

the radiance function over the z = 0 plane, as defined by Walther (W), 6 W. T. Welford and R. Winston , High Collection Nonimaging Optics , Academic...Laurel, Maryland 2072&-6099 REFERENCES IW. T. Welford and R. Winston , High Collection Nonimaging Optics , Academic Press, New York (1989). 2 W. Welford and...radiance function is invariant for a large class of optical systems. It is also shown that fundamental limitations for the concentration of light follow

Multiaperture Optical System Research.

DTIC Science & Technology

1987-11-06

pp. 179-185 (1965). 6. Welford, W. T. and Winston , R., The Optics of Nonimaging Concentrators , P. 3, Academic Press, New York (1978). 7. Schneider, R...Welford and Winston investigated it was a possible concentrator for solar energy. They came up with the "ideal concentrator ", which has walls shaped...MULTIAPZRTURE OPTICAL SYSTEM RESEARCH ." Office of Naval Research Contract Number N00014-85-C-0862 . FINAL REPORT by RTS LABORATORIES, INC. 1663

Ultrabright Head Mounted Displays Using LED-Illuminated LCOS

DTIC Science & Technology

2006-01-01

light-piping systems using surface features," in Nonimaging Optics and Efficient Illumination Systems II; Roland Winston , R. John Koshel, eds...Jay Morreale, ed. pp. 1078-1080 (Society for Information Display, San Jose, CA, 2002). 4 Roland Winston , Juan C. Mifiano, and Pablo Benitez, Nonimaging ...ferroelectric liquid-crystal-on-silicon microdisplay and a red-green-blue LED. With an 8x viewing optic giving a 35 degree diagonal field of view, the

The Reich Wreckers: An Analysis of the 306th Bomb Group During World War II

DTIC Science & Technology

1998-04-01

1983), 179-80. 12 Notes 4 Russell A. Strong, First Over Germany : The Story of the 306th Bombardment Group, (Winston-Salem, NC: Hunter Printing Co...306th Bombardment Group (H), GP-306-HI, in USAF Collection, AFHRA, 4. 7 Russell A. Strong, First Over Germany : The Story of the 306th Bombardment...306th Bomb Group Association, 1994), cover. 9 Russell A. Strong, First Over Germany : The Story of the 306th Bombardment Group, (Winston-Salem, NC: Hunter

Dietary supplementation with fish oil prevents high fat diet-induced enhancement of sensitivity to the behavioral effects of quinpirole.

PubMed

Hernandez-Casner, Caroline; Ramos, Jeremiah; Serafine, Katherine M

2017-09-01

Eating a diet high in fat can lead to negative health consequences, including obesity and insulin resistance. Omega-3 polyunsaturated fatty acids (such as those found in fish oil) prevent high fat diet-induced obesity and insulin resistance in rats. Eating a high fat diet also enhances sensitivity of rats to the behavioral effects of drugs that act on dopamine systems (e.g. quinpirole, a dopamine D2/D3 receptor agonist). To test the hypothesis that dietary supplementation with fish oil prevents high fat diet-induced enhanced sensitivity to the behavioral effects of quinpirole (0.0032-0.32 mg/kg), male rats ate standard laboratory chow, high fat chow, standard chow with fish oil, or high fat chow with fish oil (20% w/w). After 5 weeks, rats eating high fat chow were more sensitive (e.g. leftward shift of the quinpirole dose-response curve) than rats eating standard chow to yawning induced by quinpirole. Dietary supplementation with fish oil prevented this effect. That is, quinpirole dose-response curves were not different between rats eating high fat chow supplemented with fish oil and standard chow fed controls. These data add to a growing literature showing the complex relationship between diet and dopamine systems, and the health benefits of fish oil.

77 FR 63313 - SES Performance Review Board; Appointment of Members

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-16

... FURTHER INFORMATION CONTACT: Lisa M. Williams, Chief Human Capital Officer, U.S. Equal Employment.... Berry, Director, New York District Office, Equal Employment Opportunity Commission; Ms. Katherine E...

76 FR 15857 - Radio Broadcasting Services; Early and Lake Brownwood, TX

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-22

... rule. SUMMARY: The Audio Division dismisses the petition for rule making filed by Katherine Pyeatt.... Federal Communications Commission. Nazifa Sawez, Assistant Chief, Audio Division, Media Bureau. Final Rule...

78 FR 70943 - SES Performance Review Board-Appointment of Members

Federal Register 2010, 2011, 2012, 2013, 2014

2013-11-27

... FURTHER INFORMATION CONTACT: Lisa M. Williams, Chief Human Capital Officer, U.S. Equal Employment... Commission; Ms. Katherine E. Bissell, Deputy Solicitor for Regional Enforcement, Department of Labor; Ms...

77 FR 13147 - U.S. Nominations to the World Heritage List; 15-Day Notice of Opportunity for Public Comment

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-05

... Unity Temple, Oak Park, Illinois Solomon R. Guggenheim Museum, New York, New York Price Tower... Building and Research Tower, Racine, Wisconsin Taliesin, Spring Green, Wisconsin Herbert and Katherine...

75 FR 31788 - Appointments to the Medicare Payment Advisory Commission (MedPAC)

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-04

..., Group Health Cooperative; Katherine Baicker, PhD, Professor of Health Economics, Department of Health Policy and Management, Harvard School of Public Health; Mary Naylor, PhD, RN, FAAN, Professor of...

KENNEDY SPACE CENTER, FLA. - Standing in front of the Space Memorial Mirror at the KSC Visitor Complex, KSC Deputy Director Woodrow Whitlow Jr., Center Director Jim Kennedy and Executive Director of Florida Space Authority Winston Scott bow their heads in prayer during a memorial service remembering and honoring the crew of Columbia. Feb. 1 is the one-year anniversary of the loss of the crew and orbiter Columbia in a tragic accident as the ship returned to Earth following mission STS-107. Scott is a former astronaut who flew on Columbia in 1997. The public was also invited to the memorial service.

NASA Image and Video Library

2004-02-01

KENNEDY SPACE CENTER, FLA. - Standing in front of the Space Memorial Mirror at the KSC Visitor Complex, KSC Deputy Director Woodrow Whitlow Jr., Center Director Jim Kennedy and Executive Director of Florida Space Authority Winston Scott bow their heads in prayer during a memorial service remembering and honoring the crew of Columbia. Feb. 1 is the one-year anniversary of the loss of the crew and orbiter Columbia in a tragic accident as the ship returned to Earth following mission STS-107. Scott is a former astronaut who flew on Columbia in 1997. The public was also invited to the memorial service.

KENNEDY SPACE CENTER, FLA. - Winston Scott, executive director of Florida Space Authority, speaks to attendees at a memorial service honoring the crew of Columbia. He stands in front of the Space Memorial Mirror at the KSC Visitor Complex. Feb. 1 is the one-year anniversary of the loss of the crew and orbiter Columbia in a tragic accident as the ship returned to Earth following mission STS-107. Scott is a former astronaut who flew on Columbia in 1997. Attended by many friends, co-workers and families, the memorial service was also open to the public.

NASA Image and Video Library

2004-02-01

KENNEDY SPACE CENTER, FLA. - Winston Scott, executive director of Florida Space Authority, speaks to attendees at a memorial service honoring the crew of Columbia. He stands in front of the Space Memorial Mirror at the KSC Visitor Complex. Feb. 1 is the one-year anniversary of the loss of the crew and orbiter Columbia in a tragic accident as the ship returned to Earth following mission STS-107. Scott is a former astronaut who flew on Columbia in 1997. Attended by many friends, co-workers and families, the memorial service was also open to the public.

75 FR 82411 - Sunshine Act Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-30

... will be made available in alternate formats to accommodate visual and hearing impairments. Individuals who have a disability and need an accommodation to attend the meeting may notify Katherine Ward, at...

Major Robert Lawrence Memorial Tribute

NASA Image and Video Library

2017-12-08

During an Astronauts Memorial Foundation tribute honoring U.S. Air Foce Maj. Robert Lawrence, The Winston Scott “Cosmic Jazz Ensemble” performed. Participants are, from the left, former NASA astronaut Winston Scott playing trumpet, Al Dodds on bass, Stan Soloko playing drums, vocalist Shyrl “Lady Tandy” Johnson, and Ron Teixeira playing piano. Selected in 1967 for the Manned Orbiting Laboratory Program, Lawrence was the first African-American astronaut. He lost his life in a training accident 50 years ago. The ceremony took place in the Center for Space Education at the Kennedy Space Center Visitor Complex.

75 FR 16188 - Sunshine Act Meetings of the Board of Directors and Five Committees of the Board

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-31

..., meeting notices will be made available in alternate formats to accommodate visual and hearing impairments. Individuals who have a disability and need an accommodation to attend the meeting may notify Katherine Ward...

76 FR 77283 - Self-Regulatory Organizations; Financial Industry Regulatory Authority, Inc.; Notice of Filing of...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-12

... Laurence S. Moy, Pearl Zuchlewski, Linda A. Neilan and Katherine Blostein, The Neutral Corner (Volume 1--2008). In light of the changes set forth in the Dodd-Frank Act that invalidate predispute arbitration...

High-Protein Diets: Are They Safe?

MedlinePlus

Healthy Lifestyle Nutrition and healthy eating Are high-protein diets safe for weight loss? Answers from Katherine Zeratsky, R.D., L.D. For most healthy people, a high-protein diet generally isn't ...

75 FR 32227 - Sunshine Act Meeting of the Board of Directors

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-07

... available in alternate formats to accommodate visual and hearing impairments. Individuals who have a disability and need an accommodation to attend the meeting may notify Katherine Ward at (202) 295-1500 or FR...

Utility and reliability of non-invasive muscle function tests in high-fat-fed mice.

PubMed

Martinez-Huenchullan, Sergio F; McLennan, Susan V; Ban, Linda A; Morsch, Marco; Twigg, Stephen M; Tam, Charmaine S

2017-07-01

What is the central question of this study? Non-invasive muscle function tests have not been validated for use in the study of muscle performance in high-fat-fed mice. What is the main finding and its importance? This study shows that grip strength, hang wire and four-limb hanging tests are able to discriminate the muscle performance between chow-fed and high-fat-fed mice at different time points, with grip strength being reliable after 5, 10 and 20 weeks of dietary intervention. Non-invasive tests are commonly used for assessing muscle function in animal models. The value of these tests in obesity, a condition where muscle strength is reduced, is unclear. We investigated the utility of three non-invasive muscle function tests, namely grip strength (GS), hang wire (HW) and four-limb hanging (FLH), in C57BL/6 mice fed chow (chow group, n = 48) or a high-fat diet (HFD group, n = 48) for 20 weeks. Muscle function tests were performed at 5, 10 and 20 weeks. After 10 and 20 weeks, HFD mice had significantly reduced GS (in newtons; mean ± SD: 10 weeks chow, 1.89 ± 0.1 and HFD, 1.79 ± 0.1; 20 weeks chow, 1.99 ± 0.1 and HFD, 1.75 ± 0.1), FLH [in seconds per gram body weight; median (interquartile range): 10 weeks chow, 2552 (1337-4964) and HFD, 1230 (749-1994); 20 weeks chow, 2048 (765-3864) and HFD, 1036 (717-1855)] and HW reaches [n; median (interquartile range): 10 weeks chow, 4 (2-5) and HFD, 2 (1-3); 20 weeks chow, 3 (1-5) and HFD, 1 (0-2)] and higher falls [n; median (interquartile range): 10 weeks chow, 0 (0-2) and HFD, 3 (1-7); 20 weeks chow, 1 (0-4) and HFD, 8 (5-10)]. Grip strength was reliable in both dietary groups [intraclass correlation coefficient (ICC) = 0.5-0.8; P < 0.05], whereas FLH showed good reliability in chow (ICC = 0.7; P < 0.05) but not in HFD mice after 10 weeks (ICC < 0.5). Our data demonstrate that non-invasive muscle function tests are valuable and reliable tools for assessment of muscle strength and

Sea Salt vs. Table Salt: What's the Difference?

MedlinePlus

... Nutrition and healthy eating What's the difference between sea salt and table salt? Answers from Katherine Zeratsky, R.D., L.D. The main differences between sea salt and table salt are in their taste, ...

Fat Grams: How to Track Your Dietary Fat

MedlinePlus

... I eat each day, should I focus on grams, calories or percentages? Answers from Katherine Zeratsky, R. ... want to use just one method, then tracking grams is probably the easiest. The American Heart Association ...

Acai Berry Products: Do They Have Health Benefits?

MedlinePlus

... acai berries, and what are their possible health benefits? Answers from Katherine Zeratsky, R.D., L.D. ... is limited, and the claims about their health benefits haven't been proved. Acai is usually safe ...

Vitamin D Toxicity: What If You Get Too Much?

MedlinePlus

... Lifestyle Nutrition and healthy eating What is vitamin D toxicity, and should I worry about it since I take supplements? Answers from Katherine Zeratsky, R.D., L.D. Vitamin D toxicity, also called hypervitaminosis ...

"Hidden Figures" Panel Discussion

NASA Image and Video Library

2016-12-12

In the Press Site auditorium at the Kennedy Space Center in Florida, members of the media participate in a news conference with key individuals from the upcoming motion picture "Hidden Figures." From the left are: Octavia Spencer, who portrays Dorothy Vaughan; Taraji P. Henson, who portrays Katherine Johnson in the film; and Janelle Monáe, who portrays Mary Jackson. The movie is based on the book of the same title, by Margot Lee Shetterly. It chronicles the lives of Katherine Johnson, Dorothy Vaughan and Mary Jackson, three African-American women who worked for NASA as human "computers.” Their mathematical calculations were crucial to the success of Project Mercury missions including John Glenn’s orbital flight aboard Friendship 7 in 1962. The film is due in theaters in January 2017.

Early postweaning exercise improves central leptin sensitivity in offspring of rat dams fed high-fat diet during pregnancy and lactation.

PubMed

Sun, Bo; Liang, Nu-Chu; Ewald, Erin R; Purcell, Ryan H; Boersma, Gretha J; Yan, Jianqun; Moran, Timothy H; Tamashiro, Kellie L K

2013-11-01

Maternal high-fat (HF) diet has long-term consequences on the metabolic phenotype of the offspring. Here, we determined the effects of postweaning exercise in offspring of rat dams fed HF diet during gestation and lactation. Pregnant Sprague-Dawley rats were maintained on chow or HF diet throughout gestation and lactation. All pups were weaned onto chow diet on postnatal day (PND) 21. At 4 wk of age, male pups were given free access to running wheels (RW) or remained sedentary (SED) for 3 wk, after which all rats remained sedentary, resulting in four groups: CHOW-SED, CHOW-RW, HF-SED, and HF-RW. Male HF offspring gained more body weight by PND7 compared with CHOW pups and maintained this weight difference through the entire experiment. Three weeks of postweaning exercise did not affect body weight gain in either CHOW or HF offspring, but reduced adiposity in HF offspring. Plasma leptin was decreased at the end of the 3-wk running period in HF-RW rats but was not different from HF-SED 9 wk after the exercise period ended. At 14 wk of age, intracerebroventricular injection of leptin suppressed food intake in CHOW-SED, CHOW-RW, and HF-RW, while it did not affect food intake in HF-SED group. At death, HF-RW rats also had higher leptin-induced phospho-STAT3 level in the arcuate nucleus than HF-SED rats. Both maternal HF diet and postweaning exercise had effects on hypothalamic neuropeptide and receptor mRNA expression in adult offspring. Our data suggest that postweaning exercise improves central leptin sensitivity and signaling in this model.

78 FR 67333 - Performance Review Board Membership

Federal Register 2010, 2011, 2012, 2013, 2014

2013-11-12

.... Arnold William G. Bostic, Jr. Stephen B. Burke Joanne Buenzli Crane Susan R. Helper Ron S. Jarmin Enrique... Stephens Sonja Steptoe Frank A. Vitrano Katherine K. Wallman Adam Wilczewski The term of each PRB member...

Vegetarian Diet: Will It Help Me Lose Weight?

MedlinePlus

... Lifestyle Weight loss If I switch to a vegetarian diet, will I lose weight? Answers from Katherine Zeratsky, R.D., L.D. Not necessarily. A vegetarian diet is not inherently a weight-loss diet, but ...

Allopregnanolone preferentially induces energy‐rich food intake in male Wistar rats

PubMed Central

Holmberg, Ellinor; Johansson, Maja; Bäckström, Torbjörn; Haage, David

2014-01-01

Abstract Obesity is an increasing problem and identification of the driving forces for overeating of energy‐rich food is important. Previous studies show that the stress and sex steroid allopregnanolone has a hyperphagic effect on both bland food and palatable food. If allopregnanolone induces a preference for more palatable or for more energy‐rich food is not known. The aim of this study was to elucidate the influence of allopregnanolone on food preference. Male Wistar rats were subjected to two different food preference tests: a choice between standard chow and cookies (which have a higher energy content and also are more palatable than chow), and a choice between a low caloric sucrose solution and standard chow (which has a higher energy content and is less palatable than sucrose). Food intake was measured for 1 h after acute subcutaneous injections of allopregnanolone. In the choice between cookies and chow allopregnanolone significantly increased only the intake of cookies. When the standard chow was the item present with the highest caloric load, the chow intake was increased and allopregnanolone had no effect on intake of the 10% sucrose solution. The increased energy intakes induced by the high allopregnanolone dose compared to vehicle were very similar in the two tests, 120% increase for cookies and 150% increase for chow. It appears that in allopregnanolone‐induced hyperphagia, rats choose the food with the highest energy content regardless of its palatability. PMID:25501437

Calcium Supplements: Do Men Need Them Too?

MedlinePlus

... a day) Upper limit (milligrams a day) Sources: Dietary Guidelines for Americans, 2010; Institute of Medicine, 2010 19- ... calcium. With Katherine Zeratsky, R.D., L.D. Dietary Guidelines for Americans, 2010. U.S. Department of Health and ...

High-Fructose Corn Syrup: What Are the Concerns?

MedlinePlus

Healthy Lifestyle Nutrition and healthy eating What is high-fructose corn syrup? What are the health concerns? Answers from Katherine Zeratsky, R.D., L.D. High-fructose corn syrup is a common sweetener in sodas and fruit- ...

A novel MLPH variant in dogs with coat colour dilution.

PubMed

Bauer, A; Kehl, A; Jagannathan, V; Leeb, T

2018-02-01

Coat colour dilution may be the result of altered melanosome transport in melanocytes. Loss-of-function variants in the melanophilin gene (MLPH) cause a recessively inherited form of coat colour dilution in many mammalian and avian species including the dog. MLPH corresponds to the D locus in many domestic animals, and recessive alleles at this locus are frequently denoted with d. In this study, we investigated dilute coloured Chow Chows whose coat colour could not be explained by their genotype at the previously known MLPH:c.-22G>A variant. Whole genome sequencing of such a dilute Chow Chow revealed another variant in the MLPH gene: MLPH:c.705G>C. We propose to designate the corresponding mutant alleles at these two variants d 1 and d 2 . We performed an association study in a cohort of 15 dilute and 28 non-dilute Chow Chows. The dilute dogs were all either compound heterozygous d 1 /d 2 or homozygous d 2 /d 2 , whereas the non-dilute dogs carried at least one wildtype allele D. The d 2 allele did not occur in 417 dogs from diverse other breeds. However, when we genotyped a Sloughi family, in which a dilute coloured puppy had been born out of non-dilute parents, we again observed perfect co-segregation of the newly discovered d 2 allele with coat colour dilution. Finally, we identified a blue Thai Ridgeback with the d 1 /d 2 genotype. Thus, our data identify the MLPH:c.705G>C as a variant explaining a second canine dilution allele. Although relatively rare overall, this d 2 allele is segregating in at least three dog breeds, Chow Chows, Sloughis and Thai Ridgebacks. © 2018 Stichting International Foundation for Animal Genetics.

Winston Churchill Memorial Trust Fellowship Report

ERIC Educational Resources Information Center

Bramsen, Neil

2014-01-01

In March and April 2014, the author travelled overseas on a 2013 Churchill Fellowship to study education programs that successfully engage and enthuse primary and middle school students in maths, engineering and science (MES) or science, technology, engineering and maths (STEM) learning in schools, universities and institutions in the United…

Hidden Figures To Modern Figures- Students See SLS Rocket at Michoud

NASA Image and Video Library

2017-01-09

New Orleans teacher Katherine Michelle Sanders of St. Peter Claver School, takes her 7th grade science on a tour of nearby NASA’s Michoud Assembly Facility to see where the Space Launch System - the world’s most powerful rocket - is being built. Sanders is the granddaughter of famed NASA scientist Katherine Johnson who was featured in the book and movie, Hidden Figures. Sanders discusses how her grandmother’s work inspired her and why she wanted her students to learn about NASA’s plan to explore deep space. Sanders followed her grandmother's footsteps, as Katherine Johnson was also a teacher before going to work for the National Advisory Committee for Aeronautics (NACA) and later at NASA's Langley Research Center as a human computer. Due to Johnson’s historical role as one of the first African-American women to work as a NASA scientist, she was awarded the Presidential Medal of Freedom by President Barack Obama in 2015. In this video, Michoud Director Bobby Watkins and NASA engineer Renee Horton speak with the students about key components building the SLS rocket, including the Vertical Assembly Center - a large robotic tool for manufacturing hardware - and a liquid hydrogen tank that will hold fuel for the first mission, and a liquid hydrogen tank that will hold fuel for the first SLS mission. For more information on SLS, visit www.nasa.gov/sls. For more information on Michoud Assembly Facility, visit www.nasa.gov/centers/marshall/michoud/index.html

Preeclampsia

MedlinePlus

... 2018 Preeclampsia Anne Marie Valente, MD; Katherine E. Economy, MD W omen are at risk for elevations ... 10.1161/CIRCULATIONAHA.113.003858 e344 Valente and Economy  Preeclampsia   e345 Downloaded from http: / / circ. ahajournals. org/ ...

"Hidden Figures" Tour KSC

NASA Image and Video Library

2016-12-12

During a tour for cast and crew members of the upcoming motion picture "Hidden Figures," Kennedy Space Center Director Bob Cabana points to Launch Pads 39A and 39B from the roof of the Vehicle Assembly Building. From the left are Octavia Spencer, who portrays Dorothy Vaughan in the film, Cabana, Taraji P. Henson, who portrays Katherine Johnson, and Pharrell Williams, musician and producer of “Hidden Figures." The movie is based on the book of the same title, by Margot Lee Shetterly. It chronicles the lives of Katherine Johnson, Dorothy Vaughan and Mary Jackson, three African-American women who worked for NASA as human "computers.” Their mathematical calculations were crucial to the success of Project Mercury missions including John Glenn’s orbital flight aboard Friendship 7 in 1962. The film is due in theaters in January 2017.

"Hidden Figures" Tour KSC

NASA Image and Video Library

2016-12-12

Kennedy Space Center Director Bob Cabana provides a tour for cast and crew members of the upcoming motion picture "Hidden Figures." From the left are Cabana, Pharrell Williams, musician and producer of “Hidden Figures," Taraji P. Henson, who portrays Katherine Johnson in the film, and Octavia Spencer, who portrays Dorothy Vaughan. The group is walking thought the transfer aisle of the Vehicle Assembly Building. The movie is based on the book of the same title, by Margot Lee Shetterly. It chronicles the lives of Katherine Johnson, Dorothy Vaughan and Mary Jackson, three African-American women who worked for NASA as human "computers.” Their mathematical calculations were crucial to the success of Project Mercury missions including John Glenn’s orbital flight aboard Friendship 7 in 1962. The film is due in theaters in January 2017.

"Hidden Figures" Tour KSC

NASA Image and Video Library

2016-12-12

Kennedy Space Center Director Bob Cabana, right, provides a tour for cast and crew members of the upcoming motion picture "Hidden Figures." In the background is Launch Pad 14 at Cape Canaveral Air Force Station. The pad which was the location of the launch of John Glenn and three other astronauts who flew orbital missions during Project Mercury. With Cabana is Taraji P. Henson, who portrays Katherine Johnson in the film. The movie is based on the book of the same title, by Margot Lee Shetterly. It chronicles the lives of Katherine Johnson, Dorothy Vaughan and Mary Jackson, three African-American women who worked for NASA as human "computers.” Their mathematical calculations were crucial to the success of Project Mercury missions including Glenn’s orbital flight aboard Friendship 7 in 1962. The film is due in theaters in January 2017.

Taxonomy of intertidal cheilostome Bryozoa of Maceió, northeastern Brazil. Part 1: Suborders Inovicellina, Malacostegina and Thalamoporellina.

PubMed

Vieira, Leandro M; Almeida, Ana C S; Winston, Judith E

2016-03-29

Thirteen cheilostome bryozoan species from intertidal habitats of Maceió, Alagoas State, Brazil, are reported here. We describe four new species: Aetea cultrata n. sp., Biflustra marcusi n. sp., Biflustra sphinx n. sp. and Jellyella brasiliensis n. sp. Two other species of Inovicellina, Aetea arcuata Winston & Hayward, 2012, and Aetea curta Jullien, 1888, and four species of Malacostegina, Arbocuspis bellula (Hincks, 1881), Arbocuspis bicornis (Hincks, 1881), Arbocuspis ramosa (Osburn, 1940), and Jellyella tuberculata (Bosc, 1802), are reported on drift algae. Three species of Thalamoporellina are found for the first time in Maceió, Labioporella tuberculata Winston, Vieira & Woollacoot, 2014, Steginoporella           magnilabris (Busk, 1854) and Thalamoporella floridana Osburn, 1940.

KENNEDY SPACE CENTER, FLA. - A wreath and other floral arrangements rest beneath the Astronaut Memorial Mirror at the KSC Visitor Complex following a memorial service held for the crew of Columbia on the anniversary of the tragic accident that took their lives Feb. 1, 2003. The black granite mirror honors astronauts, whose names are carved in the surface, who have given their lives for space exploration.  The service included comments by Center Director Jim Kennedy, Deputy Director Woodrow Whitlow Jr., Executive Director of Florida Space Authority Winston Scott, and Dr. Stephen Feldman, president of the Astronaut Memorial Foundation, who placed the wreath at the mirror.

NASA Image and Video Library

2004-02-01

KENNEDY SPACE CENTER, FLA. - A wreath and other floral arrangements rest beneath the Astronaut Memorial Mirror at the KSC Visitor Complex following a memorial service held for the crew of Columbia on the anniversary of the tragic accident that took their lives Feb. 1, 2003. The black granite mirror honors astronauts, whose names are carved in the surface, who have given their lives for space exploration.  The service included comments by Center Director Jim Kennedy, Deputy Director Woodrow Whitlow Jr., Executive Director of Florida Space Authority Winston Scott, and Dr. Stephen Feldman, president of the Astronaut Memorial Foundation, who placed the wreath at the mirror.

KENNEDY SPACE CENTER, FLA. - A wreath and other floral arrangements rest beneath the Astronaut Memorial Mirror at the KSC Visitor Complex following a memorial service held for the crew of Columbia on the anniversary of the tragic accident that took their lives Feb. 1, 2003.  The service included comments by Center Director Jim Kennedy, Deputy Director Woodrow Whitlow Jr., Executive Director of Florida Space Authority Winston Scott, and Dr. Stephen Feldman, president of the Astronaut Memorial Foundation, who placed the wreath at the mirror.  The black granite mirror honors astronauts, whose names are carved in the surface, who have given their lives for space exploration.

NASA Image and Video Library

2004-02-01

KENNEDY SPACE CENTER, FLA. - A wreath and other floral arrangements rest beneath the Astronaut Memorial Mirror at the KSC Visitor Complex following a memorial service held for the crew of Columbia on the anniversary of the tragic accident that took their lives Feb. 1, 2003.  The service included comments by Center Director Jim Kennedy, Deputy Director Woodrow Whitlow Jr., Executive Director of Florida Space Authority Winston Scott, and Dr. Stephen Feldman, president of the Astronaut Memorial Foundation, who placed the wreath at the mirror.  The black granite mirror honors astronauts, whose names are carved in the surface, who have given their lives for space exploration.

KENNEDY SPACE CENTER, FLA. - Among the visitors placing flowers in the wire mesh fence surrounding the Space Memorial Mirror is one of the Indian dancers who performed a healing ceremony during a memorial service for the crew of Columbia. Feb. 1 is the one-year anniversary of the loss of the crew and orbiter Columbia in a tragic accident as the ship returned to Earth following mission STS-107. The public was invited to the memorial service, which included comments by Center Director Jim Kennedy and Executive Director of Florida Space Authority Winston Scott. Scott is a former astronaut who flew on Columbia in 1997.

NASA Image and Video Library

2004-02-01

KENNEDY SPACE CENTER, FLA. - Among the visitors placing flowers in the wire mesh fence surrounding the Space Memorial Mirror is one of the Indian dancers who performed a healing ceremony during a memorial service for the crew of Columbia. Feb. 1 is the one-year anniversary of the loss of the crew and orbiter Columbia in a tragic accident as the ship returned to Earth following mission STS-107. The public was invited to the memorial service, which included comments by Center Director Jim Kennedy and Executive Director of Florida Space Authority Winston Scott. Scott is a former astronaut who flew on Columbia in 1997.

KENNEDY SPACE CENTER, FLA. - In front of the Space Memorial Mirror at the KSC Visitor Complex, Center Director Jim Kennedy (right) speaks to visitors gathered for the memorial service honoring the crew of Columbia. At left are KSC Deputy Director Woodrow Whitlow Jr. and Executive Director of Florida Space Authority Winston Scott; at right is Dr. Stephen Feldman, president of the Astronaut Memorial Foundation. Feb. 1 is the one-year anniversary of the loss of the crew and orbiter Columbia in a tragic accident as the ship returned to Earth following mission STS-107. The public was also invited to the memorial service held at the KSC Visitor Complex.

NASA Image and Video Library

2004-02-01

KENNEDY SPACE CENTER, FLA. - In front of the Space Memorial Mirror at the KSC Visitor Complex, Center Director Jim Kennedy (right) speaks to visitors gathered for the memorial service honoring the crew of Columbia. At left are KSC Deputy Director Woodrow Whitlow Jr. and Executive Director of Florida Space Authority Winston Scott; at right is Dr. Stephen Feldman, president of the Astronaut Memorial Foundation. Feb. 1 is the one-year anniversary of the loss of the crew and orbiter Columbia in a tragic accident as the ship returned to Earth following mission STS-107. The public was also invited to the memorial service held at the KSC Visitor Complex.

78 FR 24815 - Proposed Collection; Comment Request for Revenue Procedure 2012-25

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-26

... DEPARTMENT OF THE TREASURY Internal Revenue Service Proposed Collection; Comment Request for Revenue Procedure 2012- 25 AGENCY: Internal Revenue Service (IRS), Treasury. ACTION: Notice and request... Katherine Dean at Internal Revenue Service, Room 6242, 1111 Constitution Avenue NW., Washington, DC 20224...

Grape Juice: Same Heart Benefits as Wine?

MedlinePlus

... eating Does grape juice offer the same heart benefits as red wine? Answers from Katherine Zeratsky, R.D., L.D. ... juices may provide some of the same heart benefits of red wine, including: Reducing the risk of blood clots Reducing ...

75 FR 68666 - Petition for Exemption; Summary of Petition Received

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-08

... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration [Summary Notice No. PE-2010-48] Petition for Exemption; Summary of Petition Received AGENCY: Federal Aviation Administration (FAA), DOT..., Federal Aviation Administration, 1601 Lind Avenue, SW., Renton, WA 98057-3356, or Katherine Haley, (202...

Dietary supplementation with fish oil prevents high fat diet-induced enhancement of sensitivity to the locomotor stimulating effects of cocaine in adolescent female rats.

PubMed

Serafine, Katherine M; Labay, Caitlin; France, Charles P

2016-08-01

Eating a diet high in fat can lead to obesity, chronic metabolic disease, and increased inflammation in both the central and peripheral nervous systems. Dietary supplements that are high in omega-3 polyunsaturated fatty acids can reduce or prevent these negative health consequences in rats. Eating high fat chow also increases the sensitivity of rats to behavioral effects of drugs acting on dopamine systems (e.g., cocaine), and this effect is greatest in adolescent females. The present experiment tested the hypothesis that dietary supplementation with fish oil prevents high fat chow induced increases in sensitivity to cocaine in adolescent female rats. Female Sprague-Dawley rats (post-natal day 25-27) ate standard laboratory chow (5.7% fat), high fat chow (34.4% fat), or high fat chow supplemented with fish oil (20% w/w). Cocaine dose dependently (1-17.8mg/kg) increased locomotion and induced sensitization across 6 weeks of once-weekly testing in all rats; however, these effects were greatest in rats eating high fat chow. Dietary supplementation with fish oil prevented enhanced locomotion and sensitization in rats eating high fat chow. There were no differences in inflammatory markers in plasma or the hypothalamus among dietary conditions. These results demonstrate that dietary supplementation with fish oil can prevent high fat diet-induced sensitization to cocaine, but they fail to support the view that these effects are due to changes in proinflammatory cytokines. These data add to a growing literature on the relationship between diet and drug abuse and extend the potential health benefits of fish oil to stimulant drug abuse prevention. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

Dietary supplementation with fish oil prevents high fat diet-induced enhancement of sensitivity to the locomotor stimulating effects of cocaine in adolescent female rats

PubMed Central

Serafine, Katherine M.; Labay, Caitlin; France, Charles P.

2016-01-01

BACKGROUND Eating a diet high in fat can lead to obesity, chronic metabolic disease, and increased inflammation in both the central and peripheral nervous systems. Dietary supplements that are high in omega-3 polyunsaturated fatty acids can reduce or prevent these negative health consequences in rats. Eating high fat chow also increases the sensitivity of rats to behavioral effects of drugs acting on dopamine systems (e.g., cocaine), and this effect is greatest in adolescent females. METHODS The present experiment tested the hypothesis that dietary supplementation with fish oil prevents high fat chow induced increases in sensitivity to cocaine in adolescent female rats. Female Sprague-Dawley rats (post-natal day 25–27) ate standard laboratory chow (5.7% fat), high fat chow (34.4% fat), or high fat chow supplemented with fish oil (20% w/w). Cocaine dose dependently (1–17.8 mg/kg) increased locomotion and induced sensitization across 6 weeks of once-weekly testing in all rats; however, these effects were greatest in rats eating high fat chow. RESULTS Dietary supplementation with fish oil prevented enhanced locomotion and sensitization in rats eating high fat chow. There were no differences in inflammatory markers in plasma or the hypothalamus among dietary conditions. CONCLUSIONS These results demonstrate that dietary supplementation with fish oil can prevent high fat diet-induced sensitization to cocaine, but they fail to support the view that these effects are due to changes in proinflammatory cytokines. These data add to a growing literature on the relationship between diet and drug abuse and extend the potential health benefits of fish oil to stimulant drug abuse prevention. PMID:27242289

The Way of the Gun: Applying Lessons of Ground Combat to Pilot Training

DTIC Science & Technology

2016-02-29

actual practice repetitions.7 Current USAF Crew/Cockpit Resource Management ( CRM ) and Aerospace Physiology courses do not include any instruction on...Burke, Clint A. Bowers, and Katherine A. Wilson. Team Training in the Skies: Does Crew Resource Management ( CRM ) Training Work? Orlando, FL

USAF/SCEEE Summer Faculty Research Program. Research Reports. Volume 1.

DTIC Science & Technology

1982-10-01

in the early years included Bessie Coleman, first black ’woman pilot, Harriet Quimby, Matilde Moisant, Katherine and Marjorie Stinson, Ruth Law, and... Martinus Nijhoff. Cavallo, R. E., 1979b, (ed.), Systems Research Movement: Characteristics, Accomplishments and Current Developments, Special Issue of

Proceedings of the Annual Midwest Research-to-Practice Conference in Adult, Continuing and Community Education (16th, East Lansing, Michigan, October 15-17, 1997).

ERIC Educational Resources Information Center

Levine, S. Joseph, Ed.

This proceedings contains 29 presentations: "Meaning of Participating in Technology Training" (Cynthia S. Blodgett-McDeavitt); "Applying Actor Network Theory to Curricular Change in Medical Schools" (Karen V. Busch); "Politics of Humanism" (Mary Katherine Cooper); "Reasons for the Nonparticipation of Adults in…

Innovation in Continuing Education Provision, Teaching and Learning: Research Perspectives. Papers from a Conference (Lancaster, England, United Kingdom, April 27, 1995).

ERIC Educational Resources Information Center

Hamilton, Mary, Ed.; Withnall, Alexandra, Ed.

The following conference papers cover a wide spectrum of issues in continuing education: "Introduction" (Katherine Leni Oglesby); "Footprints in the Sand?--The Legacy of the University Funding Council's Support for Research in Continuing Education" (Chris Duke); "Thinking Fragments: Learning, Life Histories and the…

Defense Satellite Communications: DOD Needs Additional Information to Improve Procurements

DTIC Science & Technology

2015-07-01

Acquisition of Services, GAO-02- 230 (Washington, D.C: Jan. 18, 2002); Strategic Sourcing: Improved and Expanded Use Could Save Billions in Annual...Gallegos, Assistant Director; William Allbritton; Claire Buck; James Haynes ; John Krump; Katherine Lenane; Jay Tallon; and Gwyneth Woolwine made key

Proceedings of the Annual Meeting of the Association for Education in Journalism and Mass Communication (80th, Chicago, Illinois, July 30-August 2, 1997): Science Communication.

ERIC Educational Resources Information Center

Association for Education in Journalism and Mass Communication.

The Science Communication section of the Proceedings contains the following seven papers: "Getting an Advance Look: Controversies over Embargoes in Science Journalism" (Vincent Kiernan); "Perceptions of Newspaper Bias in a Local Environmental Controversy" (Katherine A. McComas; Clifford W. Scherer; Cynthia Heffelfinger);…

Contexts Paired with Junk Food Impair Goal-Directed Behavior in Rats: Implications for Decision Making in Obesogenic Environments

PubMed Central

Kendig, Michael D.; Cheung, Ambrose M. K.; Raymond, Joel S.; Corbit, Laura H.

2016-01-01

The high prevalence of obesity and related metabolic diseases calls for greater understanding of the factors that drive excess energy intake. Calorie-dense palatable foods are readily available and often are paired with highly salient environmental cues. These cues can trigger food-seeking and consumption in the absence of hunger. Here we examined the effects of palatable food-paired environmental cues on control of instrumental food-seeking behavior. In Experiment 1, adult male rats received exposures to one context containing three “junk” foods (JFs context) and another containing chow (Chow context). Next, rats were food-deprived and trained to perform instrumental responses (lever-press) for two novel food rewards in a third, distinct context. Contextual influences on flexible control of food-seeking behavior were then assessed by outcome devaluation tests held in the JF, chow and training contexts. Devaluation was achieved using specific satiety and test order was counterbalanced. Rats exhibited goal-directed control over behavior when tested in the training and chow-paired contexts. Notably, performance was habitual (insensitive to devaluation) when tested in the JF context. In Experiment 2 we tested whether the impairment found in the JF context could be ameliorated by the presentation of a discrete auditory cue paired with the chow context, relative to a second cue paired with the JF context. Consistent with the results of Experiment 1, the devaluation effect was not significant when rats were tested in the JF context with the JF cue. However, presenting the chow cue increased the impact of the devaluation treatment leading to a robust devaluation effect. Further tests confirmed that performance in the chow context was goal-directed and that sensory-specific satiety in the JF context was intact. These results show that environments paired with palatable foods can impair goal-directed control over food-seeking behavior, but that this deficit was improved

Contexts Paired with Junk Food Impair Goal-Directed Behavior in Rats: Implications for Decision Making in Obesogenic Environments.

PubMed

Kendig, Michael D; Cheung, Ambrose M K; Raymond, Joel S; Corbit, Laura H

2016-01-01

The high prevalence of obesity and related metabolic diseases calls for greater understanding of the factors that drive excess energy intake. Calorie-dense palatable foods are readily available and often are paired with highly salient environmental cues. These cues can trigger food-seeking and consumption in the absence of hunger. Here we examined the effects of palatable food-paired environmental cues on control of instrumental food-seeking behavior. In Experiment 1, adult male rats received exposures to one context containing three "junk" foods (JFs context) and another containing chow (Chow context). Next, rats were food-deprived and trained to perform instrumental responses (lever-press) for two novel food rewards in a third, distinct context. Contextual influences on flexible control of food-seeking behavior were then assessed by outcome devaluation tests held in the JF, chow and training contexts. Devaluation was achieved using specific satiety and test order was counterbalanced. Rats exhibited goal-directed control over behavior when tested in the training and chow-paired contexts. Notably, performance was habitual (insensitive to devaluation) when tested in the JF context. In Experiment 2 we tested whether the impairment found in the JF context could be ameliorated by the presentation of a discrete auditory cue paired with the chow context, relative to a second cue paired with the JF context. Consistent with the results of Experiment 1, the devaluation effect was not significant when rats were tested in the JF context with the JF cue. However, presenting the chow cue increased the impact of the devaluation treatment leading to a robust devaluation effect. Further tests confirmed that performance in the chow context was goal-directed and that sensory-specific satiety in the JF context was intact. These results show that environments paired with palatable foods can impair goal-directed control over food-seeking behavior, but that this deficit was improved by

Hidden Figures Tour Kennedy Space Center Visitor Complex

NASA Image and Video Library

2016-12-12

In the IMAX Theater of the Kennedy Space Center Visitor Complex Cast and crew members of the upcoming motion picture "Hidden Figures" participate in a question and answer session. From the left are Ted Melfi, writer and director of “Hidden Figures,” Octavia Spencer, who portrays Dorothy Vaughan in the film, Taraji P. Henson, who portrays Katherine Johnson, Pharrell Williams, musician and producer of “Hidden Figures," and Janelle Monáe, who portrays Mary Jackson. The movie is based on the book of the same title, by Margot Lee Shetterly. It chronicles the lives of Katherine Johnson, Dorothy Vaughan and Mary Jackson, three African-American women who worked for NASA as human "computers.” Their mathematical calculations were crucial to the success of Project Mercury missions including John Glenn’s orbital flight aboard Friendship 7 in 1962. The film is due in theaters in January 2017.

"Hidden Figures" Tour KSC

NASA Image and Video Library

2016-12-12

Kennedy Space Center Director Bob Cabana, right, provides a tour for cast and crew members of the upcoming motion picture "Hidden Figures." The group is near the blockhouse at Launch Pad 14 at Cape Canaveral Air Force Station. The pad which was the location of the launch of John Glenn and three other astronauts who flew orbital missions during Project Mercury. To Cabana's right is Taraji P. Henson, who portrays Katherine Johnson in the film. The movie is based on the book of the same title, by Margot Lee Shetterly. It chronicles the lives of Katherine Johnson, Dorothy Vaughan and Mary Jackson, three African-American women who worked for NASA as human "computers.” Their mathematical calculations were crucial to the success of Project Mercury missions including Glenn’s orbital flight aboard Friendship 7 in 1962. The film is due in theaters in January 2017.

75 FR 33355 - Sunshine Act Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-11

... LEGAL SERVICES CORPORATION Sunshine Act Meeting Time and Date: The Board of Directors of the Legal...., and continue until conclusion of the Board's agenda. Location: Legal Services Corporation, 3333 K... For Information: Katherine Ward, Executive Assistant to the Vice President for Legal Affairs, at (202...

Leadership Assessment at ACSC

DTIC Science & Technology

1999-04-01

K, eds, Leadership in Education 1994-1995: A Source Book, (Greensboro, NC: Center for Creative Leadership, 1995). Freeman, Frank H., Knott, Katherine...B., and Schwartz, Mary K, eds, Leadership in Education 1996-1997, vol 2: A Source Book (Greensboro, NC: Center for Creative Leadership, 1996

Language Identification by Statistical Analysis

DTIC Science & Technology

1974-09-01

Porter, Katherine Anne, The Grave. Schwartz, Delmore, In Dreams Begin Responsibilities. Steele, Wilbur Daniel, Footfalls. Steinbeck, John, from The...Isaac Bashevis, Esther Kreindel The Second. Swados, Harvey, A Story For Teddy. Updike, John, The Lucid Eye in Silver Town. White, Robin, Walker’s

76 FR 81009 - Aviation Rulemaking Advisory Committee-New Task

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-27

... Air Tours Maintenance (CATM) Working Group, which the FAA accepted on February 1, 2011. This notice... Voluntary Accreditation Program Working Group. FOR FURTHER INFORMATION CONTACT: Katherine Haley, Office of...) and an FAA recommendation on air tour accidents. The CATM Working Group formed and met between...

78 FR 77792 - Extension of Comment Period for Proposed Interagency Policy Statement Establishing Joint...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-24

... Statement Establishing Joint Standards for Assessing the Diversity Policies and Practices of Entities... establishing standards for assessing the diversity policies and practices of the entities they regulate.\\1\\ To... Diversity and Inclusion, at (202) 452-2883; or Katherine Wheatley, Associate General Counsel, Legal Division...

Speak Up! But don't strain your voice

MedlinePlus

... the Voice Center. She was one of 105 teachers from Pennsylvania and Massachusetts who participated. Led by Katherine Verdolini, Ph.D., the trial tested which therapy was more effective at increasing volume: humming exercises or airflow practice. Once a week over five weeks, Jones received ...

Ovariectomy and overeating palatable, energy-dense food increase subcutaneous adipose tissue more than intra-abdominal adipose tissue in rats

PubMed Central

2011-01-01

Background Menopause is associated with increased adiposity, especially increased deposition of intra-abdominal (IA) adipose tissue (AT). This differs from common or 'dietary' obesity, i.e., obesity apparently due to environmentally stimulated overeating, in which IAAT and subcutaneous (S) AT increase in similar proportions. The effect of menopause on adiposity is thought to be due to the decreased secretion of ovarian estrogens. Ovariectomy in rats and other animals is a commonly used model of menopause. It is well known that ovariectomy increases adiposity and that this can be reversed by estradiol treatment, but whether ovariectomy selectively increases IAAT has not been measured directly. Therefore, we used micro-computed tomography (microCT) to investigate this question in both chow-fed and dietary-obese rats. Methods Ovariectomized, ovariectomized and estradiol treated, and sham-operated (intact) rats were fed chow or chow plus Ensure (Abbott Nutrition; n = 7/group). Total (T) AT, IAAT and SAT were measured periodically by microCT. Regional distribution of AT was expressed as IAAT as a percentage of TAT (%IAAT). Excesses in these measures were calculated with respect to chow-fed intact rats to control for normal maturational changes. Chemical analysis of fat was done in chow-fed intact and ovariectomized rats at study end. Data were analyzed by t-tests and planned comparisons. Results Body mass, TAT, total fat mass, fat-free body mass, and %IAAT all increased in chow-fed intact rats during the 41 d study. In chow-fed rats, ovariectomy increased excess body mass, TAT, fat mass, fat-free body mass, and SAT, but had little effect on IAAT, in chow-fed rats, leading to a decrease in %IAAT. Ensure feeding markedly increased SAT, IAAT and TAT and did not significantly affect %IAAT. Ovariectomy had similar effects in Ensure-fed rats as in chow-fed rats, although less statistically reliable. Estradiol treatment prevented all the effects of ovariectomy. Conclusions

Mitochondrial antioxidative capacity regulates muscle glucose uptake in the conscious mouse: effect of exercise and diet.

PubMed

Kang, Li; Lustig, Mary E; Bonner, Jeffrey S; Lee-Young, Robert S; Mayes, Wesley H; James, Freyja D; Lin, Chien-Te; Perry, Christopher G R; Anderson, Ethan J; Neufer, P Darrell; Wasserman, David H

2012-10-15

The objective of this study was to test the hypothesis that exercise-stimulated muscle glucose uptake (MGU) is augmented by increasing mitochondrial reactive oxygen species (mtROS) scavenging capacity. This hypothesis was tested in genetically altered mice fed chow or a high-fat (HF) diet that accelerates mtROS formation. Mice overexpressing SOD2 (sod2(Tg)), mitochondria-targeted catalase (mcat(Tg)), and combined SOD2 and mCAT (mtAO) were used to increase mtROS scavenging. mtROS was assessed by the H(2)O(2) emitting potential (JH(2)O(2)) in muscle fibers. sod2(Tg) did not decrease JH(2)O(2) in chow-fed mice, but decreased JH(2)O(2) in HF-fed mice. mcat(Tg) and mtAO decreased JH(2)O(2) in both chow- and HF-fed mice. In parallel, the ratio of reduced to oxidized glutathione (GSH/GSSG) was unaltered in sod2(Tg) in chow-fed mice, but was increased in HF-fed sod2(Tg) and both chow- and HF-fed mcat(Tg) and mtAO. Nitrotyrosine, a marker of NO-dependent, reactive nitrogen species (RNS)-induced nitrative stress, was decreased in both chow- and HF-fed sod2(Tg), mcat(Tg), and mtAO mice. This effect was not changed with exercise. Kg, an index of MGU was assessed using 2-[(14)C]-deoxyglucose during exercise. In chow-fed mice, sod2(Tg), mcat(Tg), and mtAO increased exercise Kg compared with wild types. Exercise Kg was also augmented in HF-fed sod2(Tg) and mcat(Tg) mice but unchanged in HF-fed mtAO mice. In conclusion, mtROS scavenging is a key regulator of exercise-mediated MGU and this regulation depends on nutritional state.

Castration, dopamine and food choice: a cost/benefit test in male hamsters.

PubMed

Chu, Lucy; Wood, Ruth I

2002-10-17

Testosterone is essential for copulation, and contributes to sexual motivation. In addition, castrated males are fatter and less active, suggesting that androgens may play a role in non-sexual behaviors, including food-related responses. To test this hypothesis, male hamsters were trained with a cost/benefit test, which compares operant responding for more-preferred food versus ad libitum consumption of lab chow. Males were tested before and after castration. The effect of the dopamine antagonist, haloperidol, on instrumental responses in intact and castrated males was also determined. Food-deprived hamsters responded vigorously for 45 mg Bio-Serv pellets in daily 30-min tests (665 presses, 6.0+/-0.9 g). When lab chow was available, males continued to respond for pellets (3.6+/-0.6 g) over chow ad libitum (1.2+/-0.3 g). Dopamine is central to this response because haloperidol (1.0 mg/kg i.p.) reversed food intake (pellets: 0.5+/-0.1 g; chow 2.0+/-0.5 g). Castration had no effect on operant responding for pellets alone (6.6+/-0.7 g). When chow was present, castrates consumed an even greater proportion of their total food intake as pellets [6.0+/-0.4 g pellets (92%), 1.6+/-0.5 g chow (8%), vs. 75 and 25%, respectively, for intact males]. This is contrary to our original hypothesis. In addition, castration did not change the effects of haloperidol on food intake: (0.4+/-0.1 g pellets; 1.6+/-0.5 g chow). These results support previous findings in rats that dopamine affects response allocation in a cost/benefit test. However, they do not support the hypothesis that testosterone modifies the allocation of food-related responses.

Seeking behavior, place conditioning, and resistance to conditioned suppression of feeding in rats intermittently exposed to palatable food.

PubMed

Velázquez-Sánchez, Clara; Santos, Jeffrey W; Smith, Karen L; Ferragud, Antonio; Sabino, Valentina; Cottone, Pietro

2015-04-01

Binge eating disorder is characterized by excessive consumption of highly palatable food within short periods of time accompanied by loss of control over eating. Extensive evidence provides support for the consideration of binge eating disorder as an addiction-like disorder. In this study, we wanted to determine whether rats undergoing an operant binge-like eating procedure could develop maladaptive forms of conditioned feeding behaviors. For this purpose, we trained male rats to self-administer either a sugary, highly palatable diet ("Palatable" rats) or a chow diet ("Chow" rats) for 1 hour a day. After escalation and stabilization of palatable food intake, we tested Chow and Palatable rats in (a) a conditioned place preference test, (b) a second-order schedule of reinforcement, (c) a cue-induced suppression of feeding test. In the conditioned place preference task, Palatable rats spent significantly more time in the compartment that was previously paired with the palatable food, compared to Chow controls. Furthermore, in the second-order schedule of reinforcement task, Palatable rats exhibited active lever responding 4- to 6-fold higher than Chow control rats. Finally, in the cue-induced suppression of feeding test, although Chow control subjects reduced responding by 32% in the presence of the conditioned punishment, Palatable rats persevered in responding despite the aversive cue. These results further characterize this animal model of binge-like eating and provide additional evidence for the addictive properties of highly palatable food. (PsycINFO Database Record (c) 2015 APA, all rights reserved).

Fluid Dynamic Mechanisms and Interactions within Separated Flows.

DTIC Science & Technology

1986-07-01

Vol. 42, Series E, No., pp. 197, pp. 387-39S. b5-bD, March N95, 18. Warpinski , N. R., and Chow, W. L., "Base Pres- 27. Chow, W. L., "Base Pressure of a...lied Rocket/Plume Fluid Dynamic Interactions, Vol. Mechanics, Vol. 46, No. 3, Sept. 197. 1, Base Flows, Fluid Dynamic Lab Report 63-101, 19. Warpinski ...34Surface Pressure Measurements ’" Warpinski , N. R. and Chow, W. L., "Base Pressure Associated on a Boattailed Projectile Shape at Transonic Speeds," ARBRL

Proceedings of the Annual Meeting of the Association for Education in Journalism and Mass Communication (74th, Boston, Massachusetts, August 7-10, 1991). Part XVI: Miscellaneous Studies, Section A.

ERIC Educational Resources Information Center

Association for Education in Journalism and Mass Communication.

Section A of the Miscellaneous Studies section of the proceedings contains the following 17 papers: "Readability Reconsidered: A Study of Reader Reactions to Differences in Fog Indexes" (Katherine C. McAdams); "Country and Nostalgia: Space and Time in Magazine Journalism" (Allen W. Palmer); "Images and Descriptions: A…

Mouse Hepatitis Virus Infection Suppresses Modulation of Mouse Spleen T- Cell Activation

DTIC Science & Technology

1988-01-01

supplemented with 50 gM 2-mercaptoethanol (Sigma, St. Louis, MO), 100 U/ml penicillin and 100 gg/ml streptomycin (Sigma). Mice were sacrificed by...husbandry and clinical studies. The authors also thank Drs. Abigail Smith, Margalit Mokyr, Robert Hendricks , Katherine Knight, Rhonna Cohen, and John

Photographic Essay.

ERIC Educational Resources Information Center

Sage: A Scholarly Journal on Black Women, 1987

1987-01-01

Presents photographs and short biographical sketches of notable Black women artists past and present, including the following: Elizabeth Taylor Greenfield, Leontyne Price, Florence Price, Ann Lundy, Katherine Dunham, Pearl Primus, Michelle Paterson, Augusta Savage, Glenda Y. Hooker, Marie L. Moore, Varnette Honeywood, Meta Vaux Warrick Fuller,…

Looking at Yourself

ERIC Educational Resources Information Center

Nash, Katherine

1976-01-01

In this interview, Katherine Nash, former teacher, group dynamics specialist and currently career consultant, has detailed a set of guidelines to help individual teachers or groups of professionals identify those things that can help them either change their direction or revitalize their present work situations. (Author/RK)

75 FR 74748 - Senior Executive Service; Appointment of Members to the Performance Review Board

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-01

... Compensation--appointment expires on 09/30/11 SOL Katherine E. Bissell, Associate Solicitor for Civil Rights and Labor Management--appointment expires on 09/30/11 SOL Michael D. Felsen, Regional Solicitor, Boston--appointment expires on 09/30/12 SOL Deborah Greenfield, Deputy Solicitor--appointment expires on...

Ray Tracing Through Non-Imaging Concentrators

NASA Astrophysics Data System (ADS)

Greynolds, Alan W.

1984-01-01

A generalized algorithm for tracing rays through both imaging and non-imaging radiation collectors is presented. A computer program based on the algorithm is then applied to analyzing various two-stage Winston concentrators.

78 FR 42975 - Notice Pursuant to the National Cooperative Research and Production Act of 1993-ODVA, Inc.

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-18

..., UNITED ARAB EMIRATES; and Jain Technology Co., Ltd., Seoul, REPUBLIC OF KOREA, have been added as parties to this venture. Also, Office FA.com Co., Ltd., Tochigi, JAPAN; and Salem Automation Inc., Winston...

"Hidden Figures" Panel Discussion

NASA Image and Video Library

2016-12-12

In the Press Site auditorium at the Kennedy Space Center in Florida, members of the media participate in a news conference with key individuals from the upcoming motion picture "Hidden Figures." From the left are: Ted Melfi (partially visible), writer and director of “Hidden Figures”; Octavia Spencer, who portrays Dorothy Vaughan; Taraji P. Henson, who portrays Katherine Johnson in the film; Janelle Monáe, who portrays Mary Jackson; Pharrell Williams, musician and producer of “Hidden Figures"; and Bill Barry, NASA's chief historian. The movie is based on the book of the same title, by Margot Lee Shetterly. It chronicles the lives of Katherine Johnson, Dorothy Vaughan and Mary Jackson, three African-American women who worked for NASA as human "computers.” Their mathematical calculations were crucial to the success of Project Mercury missions including John Glenn’s orbital flight aboard Friendship 7 in 1962. The film is due in theaters in January 2017.

"Hidden Figures" Panel Discussion

NASA Image and Video Library

2016-12-12

In the Press Site auditorium at the Kennedy Space Center in Florida, members of the media participate in a news conference with key individuals from the upcoming motion picture "Hidden Figures." From the left are: former CNN space correspondent John Zarrella, serving as moderator; Ted Melfi, writer and director of “Hidden Figures”; Octavia Spencer, who portrays Dorothy Vaughan; Taraji P. Henson, who portrays Katherine Johnson in the film; Janelle Monáe, who portrays Mary Jackson; Pharrell Williams, musician and producer of “Hidden Figures"; and Bill Barry, NASA's chief historian. The movie is based on the book of the same title, by Margot Lee Shetterly. It chronicles the lives of Katherine Johnson, Dorothy Vaughan and Mary Jackson, three African-American women who worked for NASA as human "computers.” Their mathematical calculations were crucial to the success of Project Mercury missions including John Glenn’s orbital flight aboard Friendship 7 in 1962. The film is due in theaters in January 2017.

"Hidden Figures" Panel Discussion

NASA Image and Video Library

2016-12-12

In the Press Site auditorium at the Kennedy Space Center in Florida, members of the media participate in a news conference with key individuals from the upcoming motion picture "Hidden Figures." From the left are: Ted Melfi, writer and director of “Hidden Figures”; Octavia Spencer, who portrays Dorothy Vaughan; Taraji P. Henson, who portrays Katherine Johnson in the film; Janelle Monáe, who portrays Mary Jackson; Pharrell Williams, musician and producer of “Hidden Figures"; and Bill Barry, NASA's chief historian. The movie is based on the book of the same title, by Margot Lee Shetterly. It chronicles the lives of Katherine Johnson, Dorothy Vaughan and Mary Jackson, three African-American women who worked for NASA as human "computers.” Their mathematical calculations were crucial to the success of Project Mercury missions including John Glenn’s orbital flight aboard Friendship 7 in 1962. The film is due in theaters in January 2017.

Hidden Figures Tour Kennedy Space Center Visitor Complex

NASA Image and Video Library

2016-12-12

Cast and crew members of the upcoming motion picture "Hidden Figures" participate in a question and answer session at the Kennedy Space Center Visitor Complex. From the left are Pharrell Williams, musician and producer of “Hidden Figures," Taraji P. Henson, who portrays Katherine Johnson in the film, Janelle Monáe, who portrays Mary Jackson, and Octavia Spencer, who portrays Dorothy Vaughan. They are seated in front of the original consoles of the Mercury Mission Control room with the world map that was used to follow the path of capsules between tracking stations. The movie is based on the book of the same title, by Margot Lee Shetterly. It chronicles the lives of Katherine Johnson, Dorothy Vaughan and Mary Jackson, three African-American women who worked for NASA as human "computers.” Their mathematical calculations were crucial to the success of Project Mercury missions including John Glenn’s orbital flight aboard Friendship 7 in 1962. The film is due in theaters in January 2017.

Hidden Figures Tour Kennedy Space Center Visitor Complex

NASA Image and Video Library

2016-12-12

In the IMAX Theater of the Kennedy Space Center Visitor Complex Cast and crew members of the upcoming motion picture "Hidden Figures" participate in a question and answer session. From the left are Octavia Spencer, who portrays Dorothy Vaughan in the film, Taraji P. Henson, who portrays Katherine Johnson, Janelle Monáe, who portrays Mary Jackson, Pharrell Williams, musician and producer of “Hidden Figures," Ted Melfi, writer and director of “Hidden Figures,” center director Bob Cabana, and Janet Petro, deputy center director. The movie is based on the book of the same title, by Margot Lee Shetterly. It chronicles the lives of Katherine Johnson, Dorothy Vaughan and Mary Jackson, three African-American women who worked for NASA as human "computers.” Their mathematical calculations were crucial to the success of Project Mercury missions including John Glenn’s orbital flight aboard Friendship 7 in 1962. The film is due in theaters in January 2017.

"Hidden Figures" Tour KSC

NASA Image and Video Library

2016-12-12

In the blockhouse at Cape Canaveral Air Force Station's Launch Pad 14, cast and crew members of the upcoming motion picture "Hidden Figures" listen to a briefing on the pad which was the location of the launch of John Glenn and three other astronauts who flew orbital missions during Project Mercury. In the foreground, from the left, are Octavia Spencer, who portrays Dorothy Vaughan, Taraji P. Henson, who portrays Katherine Johnson in the film, Janelle Monáe, who portrays Mary Jackson, and Pharrell Williams, musician and producer of “Hidden Figures." The movie is based on the book of the same title, by Margot Lee Shetterly. It chronicles the lives of Katherine Johnson, Dorothy Vaughan and Mary Jackson, three African-American women who worked for NASA as human "computers.” Their mathematical calculations were crucial to the success of Project Mercury missions including Glenn’s orbital flight aboard Friendship 7 in 1962. The film is due in theaters in January 2017.

Empowering Minority Communities with Health Information - WSSU

DOE Office of Scientific and Technical Information (OSTI.GOV)

McMurray, L. and W. Templin-Branner

Environmental health focus with training conducted as part of the United Negro College Fund Special Programs Corporation/National Library of Medicine HBCU ACCESS Project at Winston-Salem State University, NC on November 10, 2010.

4. Historic American Buildings Survey, Henry Pleasants, History of the ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

4. Historic American Buildings Survey, Henry Pleasants, History of the Old Eagle School, John C. Winston Co., 1909 PHOTOCOPY. - Eagle School, Old Eagle School Road (State Route 543) (Tredyffrin Township), Strafford, Chester County, PA

3. Historic American Buildings Survey, Henry Pleasants, History of the ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

3. Historic American Buildings Survey, Henry Pleasants, History of the Old Eagle School, John C. Winston Co., 1909 PHOTOCOPY. - Eagle School, Old Eagle School Road (State Route 543) (Tredyffrin Township), Strafford, Chester County, PA

Residential Group Care Quarterly. Volume 5, Number 2, Fall 2004

ERIC Educational Resources Information Center

Kirkwood, Scott, Ed.

2004-01-01

This issue of "Residential Group Care Quarterly" contains the following articles: (1) "Achieving Better Outcomes for Children and Families: Reducing the Use of Restraint and Seclusion" (Katherine Johnson); (2) "STAR Project Outcomes" (Nancy Campbell); (3) "The Devereux Glenholme School" (Mary Guilfoile); (4) "Lessons Learned in the Reduction of…

Needs or Rights? A Challenge to the Discourse of Special Education

ERIC Educational Resources Information Center

Runswick-Cole, Katherine; Hodge, Nick

2009-01-01

It is nearly 30 years since Mary Warnock's "Report of the Committee of Enquiry into the Education of Handicapped Children and Young People" introduced the phrase "special educational needs" into the UK education system. In this article, Katherine Runswick-Cole, Research Associate at Manchester Metropolitan University, and Nick…

The Writing on the Wall: Activist Rhetorics, Public Writing, and Responsible Pedagogy

ERIC Educational Resources Information Center

Sundvall, Scott; Fredlund, Katherine

2017-01-01

Drawing from their experiences teaching two different activism-focused writing courses, the authors consider the benefits, pitfalls, and potential dangers of activist writing pedagogy. Scott provides a retrospective on a rhetoric and writing course focused on the employment of digital rhetoric, while Katherine reflects on an activist-rhetoric…

Testimony Presented at an Open Hearing of the National Commission on Excellence in Teacher Education (New York, New York, October 18-19, 1984). Volume III.

ERIC Educational Resources Information Center

1984

Included are presentations on (or entitled): (1) role of schools of education (Lia Gelb); (2) teacher education programs (Katherine Sid); (3) "Quality and Quality Control in the Teaching Profession" (Hugh J. Scott); (4) "Educational Reform and Teacher Education" (Hugh G. Petrie); (5) teacher recruitment (Gladys M. Hannon); (6)…

Pacific Educational Research Journal, 2000.

ERIC Educational Resources Information Center

Berg, Kathleen, Ed.; Lai, Morris, Ed.

2000-01-01

This journal features theoretical, empirical, and applied research with implications for and relevance to education in the Pacific area. This volume contains: (1) "Community Perceptions of Culture and Education on Moloka'i" (Lois A. Yamauchi, William L. Greene, Katherine T. Ratliffe, and Andrea K. Ceppi); (2) "Academic Performance…

Facing and Transforming Hauntings of Race through the Arts

ERIC Educational Resources Information Center

Roberts, Rosemarie A.

2011-01-01

This article examines the pedagogical processes through which dance choreography and performance embody issues of social injustices. The author draws on ethnographic data of prominent black choreographers/dancers/educators, Katherine Dunham and Ronald K. Brown, to consider the behind the scene complex, interdependent practices of embodiment and to…

Exceptional Parent, 1993.

ERIC Educational Resources Information Center

Klein, Stanley D., Ed.

1993-01-01

This document consists of the nine issues of the journal "Exceptional Parent" published during 1993. This journal contains articles particularly aimed at parents of children with disabilities. Major articles published during this period are the following: "Annual Guide to Products and Services"; "Coping with Incontinence" (Katherine F. Jeter);…

Reducing Poverty through Preschool Interventions

ERIC Educational Resources Information Center

Duncan, Greg J.; Ludwig, Jens; Magnuson, Katherine A.

2007-01-01

Greg Duncan, Jens Ludwig, and Katherine Magnuson explain how providing high-quality care to disadvantaged preschool children can help reduce poverty. In early childhood, they note, children's cognitive and socioemotional skills develop rapidly and are sensitive to "inputs" from parents, home learning environments, child care settings, and the…

Maternal high-fat diet during pregnancy and lactation reduces the appetitive behavioral component in female offspring tested in a brief-access taste procedure.

PubMed

Treesukosol, Yada; Sun, Bo; Moghadam, Alexander A; Liang, Nu-Chu; Tamashiro, Kellie L; Moran, Timothy H

2014-04-01

Maternal high-fat diet appears to disrupt several energy balance mechanisms in offspring. Here, female offspring from dams fed a high-fat diet (HF) did not significantly differ in body weight compared with those fed chow (CHOW), when weaned onto chow diet. Yet when presented with both a chow and a high-fat diet, high-fat intake was significantly higher in HF compared with CHOW offspring. To assess taste-based responsiveness, offspring (12 wk old) were tested in 30-min sessions (10-s trials) to a sucrose concentration series in a brief-access taste test. Compared with CHOW, the HF offspring initiated significantly fewer trials but did not significantly differ in the amount of concentration-dependent licking. Thus, rather than affect lick response (consummatory), maternal diet affects spout approach (appetitive), which may be attributed to motivation-related mechanisms. Consistent with this possibility, naltrexone, an opioid receptor antagonist, further reduced trial initiation, but not licking in both groups. With naltrexone administration, the group difference in trial initiation was no longer evident, suggesting differences in endogenous opioid activity between the two groups. Relative expression of μ-opioid receptor in the ventral tegmental area was significantly lower in HF rats. When trial initiation was not required in one-bottle intake tests, no main effect of maternal diet on the intake of sucrose and corn oil emulsions was observed. Thus, the maternal high-fat diet-induced difference in diet preference is not likely due to changes in the sensory orosensory component of the taste stimulus but may depend on alterations in satiety signals or absorptive mechanisms.

Softened food reduces weight loss in the streptozotocin-induced male mouse model of diabetic nephropathy.

PubMed

Nørgaard, Sisse A; Sand, Fredrik W; Sørensen, Dorte B; Abelson, Klas Sp; Søndergaard, Henrik

2018-01-01

The streptozotocin (STZ)-induced diabetic mouse is a widely used model of diabetes and diabetic nephropathy (DN). However, it is a well-known issue that this model is challenged by high weight loss, which despite supportive measures often results in high euthanization rates. To overcome these issues, we hypothesized that supplementing STZ-induced diabetic mice with water-softened chow in addition to normal chow would reduce weight loss, lower the need for supportive treatment, and reduce the number of mice reaching the humane endpoint of 20% weight loss. In a 15 week STZ-induced DN study we demonstrated that diabetic male mice receiving softened chow had reduced acute weight loss following STZ treatment ( p = 0.045) and additionally fewer mice were euthanized due to weight loss. By supplementing the diabetic mice with softened chow, no mice reached 20% weight loss whereas 37.5% of the mice without this supplement reached this humane endpoint ( p = 0.0027). Excretion of corticosterone metabolites in faeces was reduced in diabetic mice on softened chow ( p = 0.0007), suggesting lower levels of general stress. Finally, it was demonstrated that the water-softened chow supplement did not significantly affect the induction of key disease parameters, i.e. %HbA1C and albuminuria nor result in abnormal teeth wear. In conclusion, supplementation of softened food is refining the STZ-induced diabetic mouse model significantly by reducing stress, weight loss and the number of animals sacrificed due to humane endpoints, while maintaining the key phenotypes of diabetes and nephropathy.

KENNEDY SPACE CENTER, FLA. - Brilliant roses and carnations frame the names of the Columbia crew carved onto the black granite surface of the Astronaut Memorial Mirror at the KSC Visitor Complex.  The flowers were left by visitors who attended a memorial service for the crew on the anniversary of the tragic accident that claimed their lives Feb. 1, 2003.  The service included comments by Center Director Jim Kennedy, Deputy Director Woodrow Whitlow Jr., Executive Director of Florida Space Authority Winston Scott, and Dr. Stephen Feldman, president of the Astronaut Memorial Foundation, who placed the wreath at the mirror.  The mirror honors astronauts who have given their lives for space exploration.

NASA Image and Video Library

2004-02-01

KENNEDY SPACE CENTER, FLA. - Brilliant roses and carnations frame the names of the Columbia crew carved onto the black granite surface of the Astronaut Memorial Mirror at the KSC Visitor Complex.  The flowers were left by visitors who attended a memorial service for the crew on the anniversary of the tragic accident that claimed their lives Feb. 1, 2003.  The service included comments by Center Director Jim Kennedy, Deputy Director Woodrow Whitlow Jr., Executive Director of Florida Space Authority Winston Scott, and Dr. Stephen Feldman, president of the Astronaut Memorial Foundation, who placed the wreath at the mirror.  The mirror honors astronauts who have given their lives for space exploration.

KENNEDY SPACE CENTER, FLA. - Roses and other flowers ring the base of the Astronaut Memorial Mirror at the KSC Visitor Complex following a memorial service held for the crew of Columbia on the anniversary of the tragic accident that took their lives Feb. 1, 2003.  The public was invited to the service and encouraged to place the flowers on the fence.  The service included comments by Center Director Jim Kennedy, Deputy Director Woodrow Whitlow Jr., Executive Director of Florida Space Authority Winston Scott, and Dr. Stephen Feldman, president of the Astronaut Memorial Foundation.  The black granite mirror honors astronauts, whose names are carved in the surface, who have given their lives for space exploration.

NASA Image and Video Library

2004-02-01

KENNEDY SPACE CENTER, FLA. - Roses and other flowers ring the base of the Astronaut Memorial Mirror at the KSC Visitor Complex following a memorial service held for the crew of Columbia on the anniversary of the tragic accident that took their lives Feb. 1, 2003.  The public was invited to the service and encouraged to place the flowers on the fence.  The service included comments by Center Director Jim Kennedy, Deputy Director Woodrow Whitlow Jr., Executive Director of Florida Space Authority Winston Scott, and Dr. Stephen Feldman, president of the Astronaut Memorial Foundation.  The black granite mirror honors astronauts, whose names are carved in the surface, who have given their lives for space exploration.

KENNEDY SPACE CENTER, FLA. - Friends, co-workers and families gather at the Space Memorial Mirror for KSC’s special service remembering and honoring the crew of Columbia. Feb. 1 is the one-year anniversary of the loss of the crew and orbiter Columbia in a tragic accident as the ship returned to Earth following mission STS-107. The public was invited to the memorial service held at the KSC Visitor Complex. Participants included Center Director Jim Kennedy, Deputy Director Woodrow Whitlow Jr., Executive Director of Florida Space Authority Winston Scott, Dr. Stephen Feldman, president of the Astronaut Memorial Foundation, and dancers from the Shoshone-Bannock Native American community in Fort Hall, Idaho.

NASA Image and Video Library

2004-02-01

KENNEDY SPACE CENTER, FLA. - Friends, co-workers and families gather at the Space Memorial Mirror for KSC’s special service remembering and honoring the crew of Columbia. Feb. 1 is the one-year anniversary of the loss of the crew and orbiter Columbia in a tragic accident as the ship returned to Earth following mission STS-107. The public was invited to the memorial service held at the KSC Visitor Complex. Participants included Center Director Jim Kennedy, Deputy Director Woodrow Whitlow Jr., Executive Director of Florida Space Authority Winston Scott, Dr. Stephen Feldman, president of the Astronaut Memorial Foundation, and dancers from the Shoshone-Bannock Native American community in Fort Hall, Idaho.

KENNEDY SPACE CENTER, FLA. - Center Director Jim Kennedy (right) speaks to attendees at a memorial service honoring the crew of Columbia. Behind him are KSC Deputy Director Woodrow Whitlow Jr. and Executive Director of Florida Space Authority Winston Scott, who is a former astronaut who flew on Columbia in 1997. They are standing in front of the Space Memorial Mirror at the KSC Visitor Complex. Attended by many friends, co-workers and families, the memorial service was also open to the public, some of whom are seen at left. Feb. 1 is the one-year anniversary of the loss of the crew and orbiter Columbia in a tragic accident as the ship returned to Earth following mission STS-107.

NASA Image and Video Library

2004-02-01

KENNEDY SPACE CENTER, FLA. - Center Director Jim Kennedy (right) speaks to attendees at a memorial service honoring the crew of Columbia. Behind him are KSC Deputy Director Woodrow Whitlow Jr. and Executive Director of Florida Space Authority Winston Scott, who is a former astronaut who flew on Columbia in 1997. They are standing in front of the Space Memorial Mirror at the KSC Visitor Complex. Attended by many friends, co-workers and families, the memorial service was also open to the public, some of whom are seen at left. Feb. 1 is the one-year anniversary of the loss of the crew and orbiter Columbia in a tragic accident as the ship returned to Earth following mission STS-107.

KENNEDY SPACE CENTER, FLA. - Center Director Jim Kennedy (right) speaks to attendees at a memorial service honoring the crew of Columbia. At left are KSC Deputy Director Woodrow Whitlow Jr. and Executive Director of Florida Space Authority Winston Scott, who was an invited speaker. Scott is a former astronaut who flew on Columbia in 1997. They are standing in front of the Space Memorial Mirror at the KSC Visitor Complex. Feb. 1 is the one-year anniversary of the loss of the crew and orbiter Columbia in a tragic accident as the ship returned to Earth following mission STS-107. Attended by many friends, co-workers and families, the memorial service was also open to the public.

NASA Image and Video Library

2004-02-01

KENNEDY SPACE CENTER, FLA. - Center Director Jim Kennedy (right) speaks to attendees at a memorial service honoring the crew of Columbia. At left are KSC Deputy Director Woodrow Whitlow Jr. and Executive Director of Florida Space Authority Winston Scott, who was an invited speaker. Scott is a former astronaut who flew on Columbia in 1997. They are standing in front of the Space Memorial Mirror at the KSC Visitor Complex. Feb. 1 is the one-year anniversary of the loss of the crew and orbiter Columbia in a tragic accident as the ship returned to Earth following mission STS-107. Attended by many friends, co-workers and families, the memorial service was also open to the public.

Adverse Impact of Diet-Induced Hypercholesterolemia on Cardiovascular Tissue Homeostasis in a Rabbit Model: Time-Dependent Changes in Cardiac Parameters

PubMed Central

Kertész, Attila; Bombicz, Mariann; Priksz, Daniel; Balla, Jozsef; Balla, Gyorgy; Gesztelyi, Rudolf; Varga, Balazs; Haines, David D.; Tosaki, Arpad; Juhasz, Bela

2013-01-01

The present study evaluates a hypothesis that diet-related hypercholesterolemia increases oxidative stress-related burden to cardiovascular tissue, resulting in progressively increased mortality, along with deterioration of electrophysiological and enzymatic function in rabbit myocardium. New Zealand white rabbits were divided into four groups, defined as follows: GROUP I, cholesterol-free rabbit chow for 12 weeks; GROUP II, cholesterol-free chow, 40 weeks; GROUP III, chow supplemented with 2% cholesterol, 12 weeks; GROUP IV, chow supplemented with 2% cholesterol, 40 weeks. At the 12 and 40 weeks time points, animals in each of the aforementioned cohorts were subjected to echocardiographic measurements, followed by sacrifice. Significant deterioration in major outcome variables measured in the present study were observed only in animals maintained for 40 weeks on 2% cholesterol-supplemented chow, with much lesser adverse effects noted in animals fed high cholesterol diets for only 12 weeks. It was observed that rabbits receiving high cholesterol diets for 40 weeks exhibited significantly increased mortality, worsened ejection fraction and general deterioration of cardiac functions, along with increased atherosclerotic plaque formation and infarct size. Additionally, myocardium of GROUP IV animals was observed to contain lower levels of heme oxygenase-1 (HO-1) and cytochrome c oxidase III (COX III) protein relative to the controls. PMID:24048247

Effects of Dietary Supplementation with Agaricus sylvaticus Schaeffer on Glycemia and Cholesterol after Streptozotocin-Induced Diabetes in Rats

PubMed Central

Mascaro, Marcelo Betti; França, Cristiane Miranda; Esquerdo, Kamilla F.; Lara, Marx A. N.; Wadt, Nilsa S. Y.; Bach, Erna E.

2014-01-01

This study evaluated the effect of the Agaricus sylvaticus (sun mushroom) on biochemical tests of the plasma and on the morphology of the pancreas in an experimental model of type I diabetes mellitus (DM1) induced by streptozotocin. One gram of dry A. sylvaticus was homogenized and mixed with the chow. Male Wistar rats were allocated as follows: normoglycemic control that received commercial chow; normoglycemic control group that received chow with A. sylvaticus; diabetic group that received commercial chow; and diabetic group that received chow with A. sylvaticus. Weight, food, and water consumption were measured every two days. Blood glucose levels were measured twice a week. After 30 days, the animals were euthanized and blood was collected for the analysis of cholesterol, HDL, triglycerides, blood sugar, glutamic-pyruvic transaminase (GPT), alkaline phosphatase, iron, transferrin, and urea. The pancreas was processed for microscopic analysis. A. sylvaticus modulated the levels of cholesterol, HDL, triglycerides, blood sugar, GPT, alkaline phosphatase, iron, transferrin, and urea to levels similar to those found in the controls and led to compensatory hyperplasia of the islets of Langerhans. A. sylvaticus is potentially beneficial in the control of type 1 diabetes, and it may also prevent pancreas damage. PMID:24971142

78 FR 54871 - Procurement List; Proposed Additions and Deletion

Federal Register 2010, 2011, 2012, 2013, 2014

2013-09-06

...: GENERAL SERVICES ADMINISTRATION, NEW YORK, NY Holiday Themed Bags, Containers and Baking Cup-Picks Set NSN... 16 oz., 6PK NSN: MR 380--Set, Baking Cups and Picks, Holiday, 24PC NPA: Winston-Salem Industries for...

New England's Other Witch-hunt: The Hartford Witch-hunt of the 1660s and Changing Patterns in Witchcraft Prosecution.

ERIC Educational Resources Information Center

Woodward, Walter W.

2003-01-01

Classifies witchcraft prosecution into three periods in New England during the seventeenth century. Focuses on the witch-hunt in Hartford, Connecticut, the trial of Katherine Harrison, and the period of skepticism toward witchcraft prosecution. Addresses the role of Governor John Winthrop, Jr. in this skepticism and the legal procedures in…

Dynamics of Interagency Cooperation Process at Provincial Reconstruction Team in Operations ISAF and Enduring Freedom

DTIC Science & Technology

2010-06-11

Carlisle, PA, 2007. Lovelace Jr, Douglas C., Richard A Chilcoat, Jay W Boggs, Dennis C Jett, John F Troxell, H Allen Irish, Joseph J Collins, Carlos...Hernandorena, Katherine Rogers, 102 Patrick B Baetjer, James J Wirtz, Scott R Feil, Robert B Polk, Amanda Smith, Robert H Dorff, James M Smith, Brian

The Fig Tree's Lessons.

ERIC Educational Resources Information Center

Hall, Kristen

1988-01-01

Describes the dramatization of Katherine Anne Porter's story,"The Fig Tree's Lessons." Discusses the process by which this story was made accessible to an audience of 8- to 12-year-old children. Notes that this program attempts to avoid the simplification of the profound human experience of dealing with death. (KO)

77 FR 61755 - Performance Review Board Members

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-11

... DEPARTMENT OF HEALTH AND HUMAN SERVICES Performance Review Board Members Title 5 U.S.C. 4314(c)(4) of the Civil Service Reform Act of 1978, Public Law 95-454, requires that the appointment of... JULIET COHEN GARY CONNOR SUZI COX VIRGINIA DANIEL KATHERINE DEL VECCHIO PAOLO DELPHIN-RITTMON MIRIAM...

Economic Education Experiences of Enterprising Teachers. Volume 31.

ERIC Educational Resources Information Center

Nappi, Andrew T., Ed.

This book describes award-winning teacher-developed projects and courses in economics. The reports are condensed versions of the original projects and are divided into grade levels. Primary Level includes: "Primary Pickle People Packed a Peck of Pickle Economics" (Karen L. Cragg; Katherine J. Van Horn); "Fabulous Economics" (Elizabeth B.…

Alternative Ways of Measuring Counselees' Jungian Psychological-Type Preferences

ERIC Educational Resources Information Center

Vacha-Haase, Tammi; Thompson, Bruce

2002-01-01

Instruments measuring Carl Jung's (1921/1971) theory of psychological types have been widely used in various counseling contexts, including career counseling, marital and family therapy, and team building. The most popular measure of types, the Myers-Briggs Type Indicator (MBTI), was developed by Katherine C. Briggs and her daughter, Isabel Briggs…

78 FR 10001 - Proposed Collection; Comment Request for Regulation Project

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-12

... Lawrence, Internal Revenue Service, room 6129, 1111 Constitution Avenue NW., Washington, DC 20224. FOR...., Washington, DC 20224, or at (202) 622-3186, or through the Internet at katherine.b[email protected] provides a timely Form W-2 or 1099, as appropriate. Current Actions: There is no change to this existing...

Medicaid: State and Federal Actions Have Been Taken to Improve Children's Access to Dental Services, but More Can Be Done. Testimony before the Subcommittee on Domestic Policy, Committee on Oversight and Government Reform, House of Representatives. GAO-10-112T

ERIC Educational Resources Information Center

Iritani, Katherine M.

2009-01-01

In this statement, Katherine M. Iritani, Acting Director, Health Care reports that dental disease remains a significant problem for children in Medicaid. Although dental services are a mandatory benefit for the 30 million children served by Medicaid, these children often experience elevated levels of dental problems and have difficulty finding…

Final Environmental Review United States Air Force Operational Capability Enhancement in Australia

DTIC Science & Technology

2013-05-15

perches; 37  Remove dead animals, termite mounds, and nests; 38  Coordinate land use off base; and 39  Report wildlife activity and incidents (DIA...EPBC-listed as vulnerable. Termite 15 mounds are also prevalent throughout the Katherine/RAAF Base Tindal area, and are a 16 significant feature of

Changing Work, Changing Workers. Critical Perspectives on Language, Literacy, and Skills. SUNY Series: Literacy, Culture, and Learning.

ERIC Educational Resources Information Center

Hull, Glynda, Ed.

These 14 papers look at U.S. factories and workplace education programs to see what is expected of workers. "Hearing Other Voices" (Glynda Hull), argues alternate viewpoints are essential to create frameworks for understanding literacy in relation to work. "Discourses of Workplace Education" (Katherine Schultz) analyzes the discourse of new…

Language Learning Disability and Individual Differences: Can We See between the Lines?

ERIC Educational Resources Information Center

Silliman, Elaine R.

2010-01-01

In honor of Dr. Katherine Butler's extraordinary leadership of "Topics in Language Disorders," this article takes up her 1982 challenge to reach toward greater understanding of individual differences in the use of oral and written language by children with language learning disability. The article focuses on 3 interconnected dimensions of learning…

Dangerous Practices: The Practicum Experiences of Non-Indigenous Pre-Service Teachers in Remote Communities

ERIC Educational Resources Information Center

Auld, Glenn; Dyer, Julie; Charles, Claire

2016-01-01

This paper seeks to explore the risks of providing preservice teachers with professional experiences in remote communities. In particular this paper focuses on the risks associated with this kind of professional experience. Twelve pre-service teachers were interviewed whilst on a three-week practicum around Katherine and in Maningrida in the…

The Pavlovian power of palatable food: lessons for weight-loss adherence from a new rodent model of cue-induced overeating

PubMed Central

Boggiano, M M; Dorsey, J R; Thomas, J M; Murdaugh, D L

2009-01-01

Objective Relapsing to overeating is a stubborn problem in obesity treatment. We tested the hypothesis that context cues surrounding palatable food (PF) intake have the power to disrupt caloric regulation even of less PF. Context cues are non-food cues that are in the environment where PF is habitually eaten. Design Rats were conditioned to associate intake of Oreo cookies as the PF to cages with distinct context cues that differed from cues in cages were they were only given chow. PF naturally stimulated greater caloric intake. The rats were then tested in the PF cage with only chow available to determine if the PF-paired cues, alone, could elicit overeating of plain chow. Subjects Non food-deprived female Sprague-Dawley rats. Measurements Intake of plain chow under PF-paired cues vs. chow-paired cues was compared. This was also measured in tests that included a morsel of PF as a priming stimulus. We also controlled for any effect of binge-prone vs. binge–resistant status to predict cued-overeating. Results Rats consumed significantly more chow when exposed to context cues previously paired with PF than with chow (p<0.01). This effect occurred using various cues (e.g., different types of bedding or wallpaper). The effect was strengthened by priming with a morsel of PF (p<0.001) and was unaffected by baseline differences in propensity to binge on PF. Conclusion Context-cues associated with PF intake can drive overeating even of a less PF and abolish the ability of rats to compensate for the calories of a PF primer. Just as drug-associated context cues can reinstate drug-addiction relapse, PF-paired cues may trigger overeating relapses linked to weight regain and obesity. This model should help identify the reflex-like biology that sabotages attempts to adhere to healthy reduced calorie regimens and call greater attention to the cue-factor in the treatment of binge-eating and obesity. PMID:19350040

Acceleration of Regeneration of Large-Gap Peripheral Nerve Injuries Using Accellular Nerve Allografts Plus Amniotic Fluid Derived Stem Cells (AFS)

DTIC Science & Technology

2015-09-01

Nerve Allografts plus amniotic Fluid Derived Stem Cells (AFS). PRINCIPAL INVESTIGATOR: Li, Zhongyu CONTRACTING ORGANIZATION: Wake Forest ...NUMBER: Wake Forest University Health Sciences Medical Center Boulevard Winston-Salem, NC 27157 9. SPONSORING / MONITORING AGENCY NAME(S) AND

Maternal high-fat diet during pregnancy and lactation reduces the appetitive behavioral component in female offspring tested in a brief-access taste procedure

PubMed Central

Sun, Bo; Moghadam, Alexander A.; Liang, Nu-Chu; Tamashiro, Kellie L.; Moran, Timothy H.

2014-01-01

Maternal high-fat diet appears to disrupt several energy balance mechanisms in offspring. Here, female offspring from dams fed a high-fat diet (HF) did not significantly differ in body weight compared with those fed chow (CHOW), when weaned onto chow diet. Yet when presented with both a chow and a high-fat diet, high-fat intake was significantly higher in HF compared with CHOW offspring. To assess taste-based responsiveness, offspring (12 wk old) were tested in 30-min sessions (10-s trials) to a sucrose concentration series in a brief-access taste test. Compared with CHOW, the HF offspring initiated significantly fewer trials but did not significantly differ in the amount of concentration-dependent licking. Thus, rather than affect lick response (consummatory), maternal diet affects spout approach (appetitive), which may be attributed to motivation-related mechanisms. Consistent with this possibility, naltrexone, an opioid receptor antagonist, further reduced trial initiation, but not licking in both groups. With naltrexone administration, the group difference in trial initiation was no longer evident, suggesting differences in endogenous opioid activity between the two groups. Relative expression of μ-opioid receptor in the ventral tegmental area was significantly lower in HF rats. When trial initiation was not required in one-bottle intake tests, no main effect of maternal diet on the intake of sucrose and corn oil emulsions was observed. Thus, the maternal high-fat diet-induced difference in diet preference is not likely due to changes in the sensory orosensory component of the taste stimulus but may depend on alterations in satiety signals or absorptive mechanisms. PMID:24500433

Spontaneous motor activity during the development and maintenance of diet-induced obesity in the rat.

PubMed

Levin, B E

1991-09-01

More than 80% of most daily spontaneous activities (assessed in an Omnitech activity monitor) occurred during the last hour of light and 12 h of the dark phase in 8 chow-fed male Sprague-Dawley rats. Thirty additional rats were, therefore, monitored over this 13-h period to assess the relationship of activity to the development and maintenance of diet-induced obesity (DIO) on a diet high in energy, fat and sucrose (CM diet). Nine of 20 rats became obese after 3 months on the CM diet, with 71% greater weight gain than 10 chow-fed controls. Eleven of 20 rats were diet resistant (DR), gaining the same amount of weight as chow-fed rats. Neither initial activity levels nor initial body weights on chow (Period I) differed significantly across retrospectively identified groups. After 3 months on CM diet or chow (Period II), as well as after an additional 3 months after CM diet-fed rats returned to chow (Period III), there were significant inverse correlations (r = -.606 to -.370) between body weight at the time of testing and various measures of movement in the horizontal plane. There was no relationship to dietary content nor consistent correlations of body weight or diet group to vertical movements, an indirect measure of ingestive behavior. Patterns of time spent in the vertical position were significantly different for DIO vs. DR rats in Period III, however. Thus, differences in food intake and metabolic efficiency, rather than differences in nocturnal activity, are probably responsible for the greater weight gain in DIO-prone rats placed on CM diet.(ABSTRACT TRUNCATED AT 250 WORDS)

Improving glucose tolerance by reducing weight gain in a polygenic obese mouse model: use of a high protein diet.

PubMed

Blair, A R; Strube, M L; Proietto, J; Andrikopoulos, S

2015-03-01

Diets to decrease body weight have limited success in achieving and importantly maintaining this weight loss long-term. It has recently been suggested that energy intake can be regulated by the amount of protein ingested, termed the protein leverage hypothesis. In this study, we determined whether a high protein diet would be effective in achieving and maintaining weight loss in a genetically obese model, the New Zealand Obese (NZO) mouse. NZO and C57BL/6J (C57) control mice were fed a high protein or chow diet for 5 weeks from weaning (3 weeks of age). Body weight and food intake were determined. Mice on the same diet were bred to produce offspring that were fed either a chow or high protein diet. Body weight, food intake, and glucose tolerance were determined. Feeding NZO and C57 mice a high protein diet for 5 weeks resulted in reduced food intake and consequently energy intake and body weight gain compared with mice on a chow diet. NZO mice fed a high protein diet showed a significant improvement in glucose tolerance compared with their chow-fed counterparts, while no difference was seen in C57 mice fed chow or protein diet. The offspring of NZO mice that were fed a high protein diet during gestation and weaning were also lighter and displayed improved glucose tolerance compared with chow fed animals. We conclude that a high protein diet is a reasonable strategy to reduce body weight gain and improve glucose tolerance in the NZO mouse, a polygenic model of obesity. © Georg Thieme Verlag KG Stuttgart · New York.

SU-G-BRB-02: An Open-Source Software Analysis Library for Linear Accelerator Quality Assurance

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kerns, J; Yaldo, D

Purpose: Routine linac quality assurance (QA) tests have become complex enough to require automation of most test analyses. A new data analysis software library was built that allows physicists to automate routine linear accelerator quality assurance tests. The package is open source, code tested, and benchmarked. Methods: Images and data were generated on a TrueBeam linac for the following routine QA tests: VMAT, starshot, CBCT, machine logs, Winston Lutz, and picket fence. The analysis library was built using the general programming language Python. Each test was analyzed with the library algorithms and compared to manual measurements taken at the timemore » of acquisition. Results: VMAT QA results agreed within 0.1% between the library and manual measurements. Machine logs (dynalogs & trajectory logs) were successfully parsed; mechanical axis positions were verified for accuracy and MLC fluence agreed well with EPID measurements. CBCT QA measurements were within 10 HU and 0.2mm where applicable. Winston Lutz isocenter size measurements were within 0.2mm of TrueBeam’s Machine Performance Check. Starshot analysis was within 0.2mm of the Winston Lutz results for the same conditions. Picket fence images with and without a known error showed that the library was capable of detecting MLC offsets within 0.02mm. Conclusion: A new routine QA software library has been benchmarked and is available for use by the community. The library is open-source and extensible for use in larger systems.« less

78 FR 24308 - Notice of Application for Special Permits

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-24

... 1, 2, 3, 4) 15838-N Primo Water, 49 CFR 171.2(k)........ To authorize the Winston-Salem, NC... amount qualifying as hazardous material. (modes 1, 2, 3, 4) 15839-N Sensors, Inc., 49 CFR 172.202, To...

Payload bay activity during second EVA of STS-72 mission

NASA Image and Video Library

1996-01-16

STS072-393-008 (17 Jan. 1996) --- Astronaut Leroy Chiao gives a thumbs up signal, marking the success of his second extravehicular activity (EVA) in three days. Chiao was joined by astronaut Winston E. Scott on this EVA.

Anthropology with an Agenda: Four Forgotten Dance Anthropologists

ERIC Educational Resources Information Center

Richter, Katrina

2010-01-01

In response to postcolonial, feminist and subaltern critiques of anthropology, this article seeks to answer the question, "For whom should research be conducted, and by whom should it be used?" by examining the lives and works of four female dance anthropologists. Franziska Boas, Zora Neale Hurston, Katherine Dunham and Pearl Primus used…

"Jacob Have I Loved." Learning Page Lesson Plan.

ERIC Educational Resources Information Center

Isaacs, Kathy

In this middle school social studies and literature lesson plan, pictures from "America from the Great Depression to World War II" in the American Memory collection provide visual images to introduce and spark curiosity about "Jacob Have I Loved" by Katherine Paterson, a novel about jealousy set on an island in the Chesapeake…

Prospective Evaluation of Mental Health and Deployment Experience Among Women in the US Military

DTIC Science & Technology

2012-07-06

Beverly Sheppard, Katherine Snell, Steven Speigle, Kari Sausedo, Jennifer Walstrom, Martin White, James Whitmer, and Char- lene Wong; Madigan Army Medical...what physicians should know. J Gen Intern Med. 2006; 21(suppl 3):S5–S10. 13. Lindstrom KE, Smith TC, Wells TS, et al. The mental health of U.S

75 FR 14359 - FM TABLE OF ALLOTMENTS, Stonewall, Texas

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-25

.... SUMMARY: The Audio Division denies the petition for rule making filed by Katherine Pyeatt, proposing the...-making proposals. For that reason, the Audio Division denied the petition for rule making and terminated..., Audio Division, Media Bureau. [FR Doc. 2010-6385 Filed 3-24-10; 8:45 am] BILLING CODE 6712-01-S ...

78 FR 26867 - Quarterly Publication of Individuals, Who Have Chosen To Expatriate

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-08

... residents, as defined in section 877(e)(2), are treated as if they were citizens of the United States who... GERRING BANG HEESEUNG BARRAZA SANTIAGO E BARTEL-MOUFANG DIANA BATTIG RAINER KARL BAUMANN MARTIN PETER... SUSANNE BARBARA HATHAWAY JANET K HAUPTLI DIANE MARIE HAY KATHERINE MARIE HEBRON VERA HEIM JULIA HEIM MARC...

Response to Evaluation Field Building in South Asia: Reflections, Anecdotes, and Questions

ERIC Educational Resources Information Center

King, Jean A.

2010-01-01

The author is increasingly sensitive to the Venn diagram of overlapping expertise in which program evaluation intersects a content area such as public health, urban education, or--in the case of Katherine Hay--international development. Many evaluators practice in these areas of overlap, experts in the evaluation of a specific domain. Given her…

Boosting Family Income to Promote Child Development

ERIC Educational Resources Information Center

Duncan, Greg J.; Magnuson, Katherine; Votruba-Drzal, Elizabeth

2014-01-01

Families who live in poverty face disadvantages that can hinder their children's development in many ways, write Greg Duncan, Katherine Magnuson, and Elizabeth Votruba-Drzal. As they struggle to get by economically, and as they cope with substandard housing, unsafe neighborhoods, and inadequate schools, poor families experience more stress in…

Between a Rock and a Hard Place: Parents' Attitudes to the Inclusion of Children with Special Educational Needs in Mainstream and Special Schools

ERIC Educational Resources Information Center

Runswick-Cole, Katherine

2008-01-01

In this paper, Katherine Runswick-Cole, a researcher at the Research Institute for Health and Social Change at Manchester Metropolitan University, engages with parents' attitudes to the placement of their children with special educational needs in mainstream and special schools. She sets her review of parents' views within the current policy and…

Between Good and Evil: Deconstructive Interpretation of "Noon Wine"

ERIC Educational Resources Information Center

Wang, Ru; Tian, Yunyun

2016-01-01

Katherine Anne Porter (1890-1980) is an eminent novelist in the history of American literature, especially famous for her short novels. "Noon Wine" is her important masterpiece, its plot and motif always lead to reader's deep meditation, and researches focus more on its narrative art, myth archetypes and themes. This paper tries to…

Engaging Novice Teachers in Semiotic Inquiry: Considering the Environmental Messages of School Learning Settings

ERIC Educational Resources Information Center

Shapiro, Bonnie

2014-01-01

Katherine Fogelberg's insightful study of the messages of zoo signs describes the complex, sometimes contradictory nature of the messages they communicate. The construction and content of signs are influenced by institutional power. Fogelberg argues that the creation of zoo signage designed to inform the public can, through its messages,…

Forum: A New Culture of Learning

ERIC Educational Resources Information Center

Hess, Mary E.; Gallagher, Eugene V.; Turpin, Katherine

2014-01-01

These brief essays by Mary Hess, Eugene Gallagher, and Katherine Turpin are solicited responses from three different contexts to the provocative book by Douglas Thomas and John Seely Brown, "The New Culture of Learning" (2011). Mary Hess writes from a seminary context, providing a critical summary of the authors' major concepts and…

Reducing the Effects of Poverty through Early Childhood Interventions. Fast Focus. No. 17-2013

ERIC Educational Resources Information Center

Magnuson, Katherine

2013-01-01

Katherine Magnuson's research focuses on the well-being and development of economically disadvantaged children and their families. In the first half of this brief Magnuson pulls together scholarship on the effects of poverty and inequality on children, especially from infancy to age five. Her scope goes beyond the social sciences to include new…

Sir Gawain Was Just Out of Middle School....

ERIC Educational Resources Information Center

Probst, Robert E.

2002-01-01

Notes that what all middle school students need is another kid like them but with words. Presents some examples of adolescents going through the rites of passage--someone like T.J. in Chris Crutcher's "Whale Talk," or Sara Louise Bradshaw in Katherine Paterson's "Jacob Have I Loved," or Brian in Gary Paulson's…

75 FR 34463 - Oversight of Laboratory Developed Tests; Public Meeting; Request for Comments

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-17

.../default.htm . Online registration is available until 5 p.m. on July 12, 2010. Persons without Internet access may call Katherine Serrano at 301-796-6652 by July 12, 2010, to register for the meeting. Early... be available on the Internet at http://www.fda.gov/MedicalDevices/NewsEvents/WorkshopsConferences...

Start with a Story: Five Schools and a Zoo Use the One Book, One Community Model to Bridge STEM into STEAM

ERIC Educational Resources Information Center

Brock, Patricia; Dunifon, Sarah; Nagel, Lisa

2016-01-01

This article outlines an integrated STEAM project based on "The One and Only Ivan" by Katherine Applegate (2012). Elementary students focused on real-world, authentic problems presented in this 2013 Newbery Award-winning novel. The novel deals with difficult issues such as the humane treatment of animals, and has a powerful message of…

What a Character! Character Study as a Guide to Literary Meaning Making in Grades K?8

ERIC Educational Resources Information Center

Roser, Nancy L., Ed.; Martinez, Miriam G., Ed.; Yokota, Junko; O'Neal, Sharon

2005-01-01

Bring text and its meaning alive for students! This collection offers the perspectives of classroom teachers, researchers, and children's book authors, including award-winners Kate DiCamillo and Katherine Paterson. Together, they share their thoughts on the power of character study and how to use it to guide elementary-and middle-grade students…

Churchill, Moran and the struggle for survival.

PubMed

Beasley, A W

2010-12-01

This paper examines the association between Winston Churchill and Charles McMoran Wilson, later Lord Moran, who was made personal physician to Churchill in 1940 at the instigation of the Cabinet when Churchill became prime minister of wartime Britain.

Pulse Pressure: An Indicator of Heart Health?

MedlinePlus

... ESH/ESC guidelines for the management of arterial hypertension. Journal of Hypertension. 2013;31:1281. Winston GJ, et al. Pulse ... in the multi-ethnic study of atherosclerosis. American Journal of Hypertension. 2013; 26:636. Jackson CE, et al. Differing ...

A Canola Oil-Supplemented Diet Prevents Type I Diabetes-Caused Lipotoxicity and Renal Dysfunction in a Rat Model.

PubMed

Cano-Europa, Edgar; Ortiz-Butron, Rocio; Camargo, Estela Melendez; Esteves-Carmona, María Miriam; Oliart-Ros, Rosa Maria; Blas-Valdivia, Vanessa; Franco-Colin, Margarita

2016-11-01

We investigated the effect of a canola oil-supplemented diet on the metabolic state and diabetic renal function of a type I diabetes experimental model. Male Sprague-Dawley rats were randomly divided into four groups: (1) normoglycemic+chow diet, (2) normoglycemic+a canola oil-supplemented chow diet, (3) diabetic+chow diet, and (4) diabetic+a canola oil-supplemented chow diet. For 15 weeks, animals were fed a diet of Purina rat chow alone or supplemented with 30% canola oil. Energetic intake, water intake, body weight, and adipose tissue fat pad were measured; renal function, electrolyte balance, glomerular filtration rate, and the plasmatic concentration of free fatty acids, cholesterol, triglycerides, and glucose were evaluated. The mesenteric, retroperitoneal, and epididymal fat pads were dissected and weighed. The kidneys were used for lipid peroxidation (LP) and reactive oxygen species (ROS) quantifications. Diabetic rats fed with a canola oil-supplemented diet had higher body weights, were less hyperphagic, and their mesenteric, retroperitoneal, and epididymal fat pads weighed more than diabetic rats on an unsupplemented diet. The canola oil-supplemented diet decreased plasmatic concentrations of free fatty acids, triglycerides, and cholesterol; showed improved osmolarity, water clearances, and creatinine depuration; and had decreased LP and ROS. A canola oil-supplemented diet decreases hyperphagia and prevents lipotoxicity and renal dysfunction in a type I diabetes mellitus model.

The effects of dietary fish oil on inflammation, fibrosis and oxidative stress associated with obstructive renal injury in rats.

PubMed

Peake, Jonathan M; Gobe, Glenda C; Fassett, Robert G; Coombes, Jeff S

2011-03-01

We examined whether dietary supplementation with fish oil modulates inflammation, fibrosis and oxidative stress following obstructive renal injury. Three groups of Sprague-Dawley rats (n=16 per group) were fed for 4 wk on normal rat chow (oleic acid), chow containing fish oil (33 g eicosapentaenoic acid and 26 g docosahexaenoic acid per kg diet), or chow containing safflower oil (60 g linoleic acid per kg diet). All diets contained 7% fat. After 4 wk, the rats were further subdivided into four smaller groups (n=4 per group). Unilateral ureteral obstruction was induced in three groups (for 4, 7 and 14 days). The fourth group for each diet did not undergo surgery, and was sacrificed as controls at 14 days. When rats were sacrificed, plasma and portions of the kidneys were removed and frozen; other portions of kidney tissue were fixed and prepared for histology. Compared with normal chow and safflower oil, fish oil attenuated collagen deposition, macrophage infiltration, TGF-β expression, apoptosis, and tissue levels of arachidonic acid, MIP-1α, IL-1β, MCP-1 and leukotriene B(4). Compared with normal chow, fish oil increased the expression of HO-1 protein in kidney tissue. Fish oil intake reduced inflammation, fibrosis and oxidative stress following obstructive renal injury. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Does eating good-tasting food influence body weight?

PubMed

Tordoff, Michael G; Pearson, Jordan A; Ellis, Hillary T; Poole, Rachel L

2017-03-01

Does eating good-tasting food influence body weight? To investigate, we first established some concentrations of sucralose and mineral oil in chow that mice strongly preferred. Then, in Experiment 1, we compared groups of 16 mice fed plain chow (i.e., chow with no additives) to groups fed chow with added (a) sucralose, (b) mineral oil, (c) sucralose and mineral oil, or (d) sucralose on odd days and mineral oil on even days. During a 6-week test, the body weights and body compositions of the five groups never differed. In Experiment 2, we compared groups of 18 mice fed plain chow or plain high-fat diet to groups fed these diets with added sucralose. During a 9-week test, the high-fat diet caused weight gain, but the body weights of mice fed the sucralose-sweetened diets did not differ from those fed the corresponding plain versions. Two-cup choice tests conducted at the end of each experiment showed persisting strong preferences for the diets with added sucralose and/or mineral oil. In concert with earlier work, our results challenge the hypothesis that the orosensory properties of a food influence body weight gain. A good taste can stimulate food intake acutely, and guide selection toward nutrient-dense foods that cause weight gain, but it does not determine how much is eaten chronically. Copyright © 2016 Elsevier Inc. All rights reserved.

Does eating good-tasting food influence body weight?

PubMed Central

Tordoff, Michael G.; Pearson, Jordan A.; Ellis, Hillary T.; Poole, Rachel L.

2016-01-01

Does eating good-tasting food influence body weight? To investigate, we first established some concentrations of sucralose and mineral oil in chow that mice strongly preferred. Then, in Experiment 1, we compared groups of 16 mice fed plain chow (i.e., chow with no additives) to groups fed chow with added (a) sucralose, (b) mineral oil, (c) sucralose and mineral oil, or (d) sucralose on odd days and mineral oil on even days. During a 6-week test, the body weights and body compositions of the five groups never differed. In Experiment 2, we compared groups of 18 mice fed plain chow or plain high-fat diet to groups fed these diets with added sucralose. During a 9-week test, the high-fat diet caused weight gain, but the body weights of mice fed the sucralose-sweetened diets did not differ from those fed the corresponding plain versions. Two-cup choice tests conducted at the end of each experiment showed persisting strong preferences for the diets with added sucralose and/or mineral oil. In concert with earlier work, our results challenge the hypothesis that the orosensory properties of a food influence body weight gain. A good taste can stimulate food intake acutely, and guide selection toward nutrient-dense foods that cause weight gain, but it does not determine how much is eaten chronically. PMID:27988248

Trends in Operational Fuel Use

DTIC Science & Technology

2016-08-01

Wikipedia, The Free Encyclopedia. Chow Test. Viewed July 18, 2016 at: https://en.wikipedia.org/wiki/Chow_test 8. CNA Research Memorandum CRM 86-178. Ship...Gren Landry and Gregory Suess. May 2006 10. CNA, CRM D0026186.A2/Final. Vessel Traffic in the Hawaii-Southern California and Atlantic Fleet Testing

FAA Weather Surveillance Requirements in the Context on NEXRAD.

DTIC Science & Technology

1982-11-19

NEXRAD Technical Requirements NUOC NEXRAD User’s Operations Concept NWS National Weather Service Pd Probability of Detection Pfa Probability of False...Winston 25. Minneapolis-St. Paul Intl. Salem Regional 26. Jacksonville International 54. Bradley International 27. Newark International 55. Roanoke

Editorial Conference Comments by the Editors

NASA Astrophysics Data System (ADS)

Williams, Richard; Melcher, Chuck; Ferris, Kim; Moses, Bill; Ucer, Burak

2008-06-01

Introduces the special issue of papers from the 9th International Conference on Inorganic Scintillators and Their Applications (SCINT), held in Winston-Salem, NC, from June 4 to June 8, 2007. There are 102 papers from this conference in this issue.

75 FR 47631 - Douglas Battery Manufacturing Co., Currently Known as Lexington Road Properties, Inc., Including...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-06

... DEPARTMENT OF LABOR Employment and Training Administration [TA-W-72,430] Douglas Battery... Battery Manufacturing Co., including on-site leased workers from Winston Personnel Group, Aerotek, and... and industrial batteries. New information shows that in January 2010, Douglas Battery Manufacturing...

Anthropology with Activism: Settling Its Value

ERIC Educational Resources Information Center

Hull, Glynda A.

2014-01-01

This response to Katherine Schultz's Presidential Address to the Council on Anthropology and Education explores the themes of temporality and reflexivity in activist scholarship, with Schultz's research as prime example. The need to take action to address a crisis, juxtaposed to the counter need to take time for scholarly reflection and…

Fulbright-Hays Summer Seminars Abroad Program 1989. Egypt: Transition to the Modern World.

ERIC Educational Resources Information Center

Office of International Education (ED), Washington, DC.

This document consists of four papers on various aspects of development in Egypt prepared by participants in the Fulbright-Hays Seminars Abroad Program in Egypt in 1989. Four of the papers are descriptive, one is a lesson plan. The papers included are: (1) "Egypt: Transition to Modern Times" (Katherine Jensen) focuses on the role of…

77 FR 41436 - Announcement of Funding Awards; Fair Housing Initiatives Program Fiscal Year 2012

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-13

... Inc., 161 Cesar Chevaz Street, Katherine Stark, 512-474-7007. 6 324,723.00 Austin, TX 78702. Greater... Espinoza, 469-941-0383 6 261,589.00 Drive, Suite 130, Dallas, TX 75235. Fair Housing Council of Oregon, 506...-733-3247.... 6 325,000.00 Drive, Suite 229, San Antonio, TX 78228. Family Housing Advisory Services...

From the Field: Interview with Susan R. Easterbrooks and Ellen L. Estes

ERIC Educational Resources Information Center

Montgomery, Judy

2010-01-01

This article presents an interview with Susan R. Easterbrooks, a professor of deaf education in the Educational Psychology and Special Education Department at Georgia State University in Atlanta, and Ellen L. Estes, the coordinator of the Katherine Hamm Center at the Atlanta Speech School, on their new book "Helping Deaf and Hard of Hearing…

Rediscovering the Joy of Poetry

ERIC Educational Resources Information Center

Keil, Katherine

2005-01-01

Katherine Keil, a high school English teacher, has developed an approach that goes beyond simply teaching poetry to creating classrooms that celebrate poetry in order to overcome the fear of poetry in students and the teacher. She encourages students to play with language, publishes student's work to a web site and models the writing process…

Update on Research and Leadership, Fall 2001-Spring 2002.

ERIC Educational Resources Information Center

Barnett, Elisabeth, Ed.

2001-01-01

This issue of On Research and Leadership Update (v13 n1) focuses on the concerns surrounding dual enrollment and dual credit. "Dual Enrollment Programs: Assessing the American Dream," by Katherine Boswell, addresses the problems inherent in development of these programs when institutions fail to collaborate with one another in an effective way.…

Reflections on Becoming a Researcher

ERIC Educational Resources Information Center

Frankel, Katherine K.; Pearson, P. David

2013-01-01

In this joint reflection two of the contributors to this issue of the "Journal of Education" consider the processes and practices that led to the publication of their respective pieces. Since one of the authors, Katherine Frankel, was a doctoral advisee of the other, David Pearson, they also reflect on the mentoring practices they shared…

Students At-Risk: Poverty, Pregnancy, Violence, Depression, and the Demise of the Traditional Family. Second Edition.

ERIC Educational Resources Information Center

Bonilla, Carlos A., Ed.; Goss, Joyce, Ed.; Lauderdale, Katherine Lynn, Ed.

This book was designed by a group of teachers and would-be teachers to let their voices be heard, their concerns aired, their suggestions heralded, and their ideas concerning students at risk be proclaimed. The following articles are presented: (1) "Children in Poverty" (Cris Fruzza, Carlos A. Bonilla, Katherine L. Lauderdale, Eric Affleck); (2)…

Glucosamine enhances body weight gain and reduces insulin response in mice fed chow diet but mitigates obesity, insulin resistance and impaired glucose tolerance in mice high-fat diet.

PubMed

Hwang, Ji-Sun; Park, Ji-Won; Nam, Moon-Suk; Cho, Hyeongjin; Han, Inn-Oc

2015-03-01

This study investigated the potential of glucosamine (GlcN) to affect body weight gain and insulin sensitivity in mice normal and at risk for developing diabetes. Male C57BL/6J mice were fed either chow diet (CD) or a high fat diet (HFD) and the half of mice from CD and HFD provided with a solution of 10% (w/v) GlcN. Total cholesterol and nonesterified free fatty acid levels were determined. Glucose tolerance test and insulin tolerance test were performed. HepG2 human hepatoma cells or differentiated 3T3-L1 adipocytes were stimulated with insulin under normal (5 mM) or high glucose (25 mM) conditions. Effect of GlcN on 2-deoxyglucose (2-DG) uptake was determined. JNK and Akt phosphorylation and nucleocytoplasmic protein O-GlcNAcylation were assayed by Western blotting. GlcN administration stimulated body weight gain (6.58±0.82 g vs. 11.1±0.42 g), increased white adipose tissue fat mass (percentage of bodyweight, 3.7±0.32 g vs. 5.61±0.34 g), and impaired the insulin response in livers of mice fed CD. However, GlcN treatment in mice fed HFD led to reduction of body weight gain (18.02±0.66 g vs. 16.22±0.96 g) and liver weight (2.27±0.1 vs. 1.85±0.12 g). Furthermore, obesity-induced insulin resistance and impaired Akt insulin signaling in the liver were alleviated by GlcN administration. GlcN inhibited the insulin response under low (5 mM) glucose conditions, whereas it restored the insulin response for Akt phosphorylation under high (25 mM) glucose conditions in HepG2 and 3T3-L1 cells. Uptake of 2-DG increased upon GlcN treatment under 5 mM glucose compared to control, whereas insulin-stimulated 2-DG uptake decreased under 5 mM and increased under 25 mM glucose in differentiated 3T3-L1 cells. Our results show that GlcN increased body weight gain and reduced the insulin response for glucose maintenance when fed to normal CD mice, whereas it alleviated body weight gain and insulin resistance in HFD mice. Therefore, the current data support the integrative

"Hidden Figures" Tour KSC

NASA Image and Video Library

2016-12-12

During a tour for cast and crew members of the upcoming motion picture "Hidden Figures," Kennedy Space Center Director Bob Cabana poses with the group on the roof of the Vehicle Assembly Building. Among those participating are Kelvin Manning, associate center director; Meredith Lipsky, vice president of Field Marketing for 20th Century Fox; Ted Melfi, writer and director of “Hidden Figures;” Michelle Ryan, executive producer of the film; Pharrell Williams, musician and producer of “Hidden Figures;" Octavia Spencer, who portrays Dorothy Vaughan; Taraji P. Henson, who portrays Katherine Johnson in the film; Janet Petro, deputy center director; and Cabana. The movie is based on the book of the same title, by Margot Lee Shetterly. It chronicles the lives of Katherine Johnson, Dorothy Vaughan and Mary Jackson, three African-American women who worked for NASA as human "computers.” Their mathematical calculations were crucial to the success of Project Mercury missions including John Glenn’s orbital flight aboard Friendship 7 in 1962. The film is due in theaters in January 2017.

Dietary variety is associated with larger meals in female rhesus monkeys.

PubMed

Moore, Carla J; Michopoulos, Vasiliki; Johnson, Zachary P; Toufexis, Donna; Wilson, Mark E

2013-07-02

The complex, interacting influences on eating behavior and energy expenditure prevent elucidation of the causal role of any single factor in the current obesity epidemic. However, greater variety in the food supply, particularly in the form of highly palatable, energy-dense foods, has likely made a contribution. This study was undertaken to test the hypothesis that greater dietary variety is associated with greater caloric intake within individual meals consumed by free-feeding, socially-housed female rhesus monkeys. Meal patterns were assessed during two, two-week dietary phases. One phase consisted of a choice between a standard chow diet and a highly palatable diet (HPD). The other phase consisted of access to the chow only. Food intake for each subject was recorded continuously using previously validated, automated feeders, and a meal was defined based on a minimum kilocalorie requirement and a minimum inter-meal interval. During the choice condition, animals electively consumed mixed meals that incorporated both diets as well as other meals that consisted exclusively of a single diet - chow-only or HPD-only. Animals consumed the most calories per meal when the meal was comprised of both the chow and HPD, which differed in caloric density, flavor, and texture. Interestingly, however, there was no significant difference in the amount of calories consumed as HPD-only meals in the choice condition compared to meals in the chow-only, no choice condition, suggesting consumption of a single food during a meal, regardless of palatability, provides a constant sensory experience that may lead to more rapid habituation and subsequent meal cessation. Additionally, during the dietary choice condition, animals consumed fewer calories in the form of chow-only meals. Thus, the present results suggest that limiting dietary variety, regardless of palatability, may be a useful strategy for weight loss in overweight and obese individuals by reducing caloric intake within

Novel role of GLP-1 receptor signaling in energy expenditure during chronic high fat diet feeding in rats.

PubMed

Krieger, Jean-Philippe; Langhans, Wolfgang; Lee, Shin J

2018-04-11

Glucagon-like peptide-1 (GLP-1) secreted from intestinal L-cells plays a major role in meal termination and glucose-dependent insulin secretion. Several lines of evidence indicate, however, that the acute satiating and incretin effects of GLP-1 are attenuated with high fat diet (HFD) exposure. Here we tested the hypothesis that endogenous GLP-1 differentially affects energy balance and glucose homeostasis dependent on whether rats are fed chow or HFD (60% energy from fat). We blocked GLP-1 receptor (GLP-1R) signaling by daily intraperitoneal (IP) injection of the GLP-1R antagonist exendin (9-39) (Ex9, 10 μg/kg) or vehicle for 5 weeks in male Sprague-Dawley rats fed either chow or HFD, recorded body weight (BW) and food intake throughout, and assessed energy expenditure (3rd week) and glucose tolerance (4th week). Five week daily Ex9 injections reduced BW gain in HFD-fed rats, but did not affect BW in chow-fed rats. On the other hand, chronic Ex9 treatment did not affect daily food intake in either chow or HFD-fed rats during the entire study. The reduced BW gain in HFD-fed rats was associated with an increase in energy expenditure. Interestingly, chronic Ex9 treatment induced glucose intolerance in chow-fed rats, but not in HFD-fed rats, suggesting a differential role of GLP-1R signaling in glucose metabolism during chow and HFD feeding. Our findings reveal a novel role of GLP-1R signaling, modulating energy expenditure rather than eating behavior during HFD feeding. Furthermore, these results suggest a previously unrecognized contribution of GLP-1R signaling to the pathophysiology of obesity. Copyright © 2018 Elsevier Inc. All rights reserved.

The Effects of Long-Term Feeding of Rodent Food Bars on Lipid Peroxidation And Antioxidant Enzyme Levels In Fisher Rats

NASA Technical Reports Server (NTRS)

Ramirez, Joel; Zirkle-Yoshida, M.; Piert, S.; Barrett, J.; Yul, D.; Dalton, B.; Girten, B.

2001-01-01

A specialized rodent food bar diet has been developed and utilized successfully for short-duration shuttle missions. Recent tests conducted in preparation for experiments aboard the International Space Station (ISS) indicated that long-term food bar feeding for three months induced hyperlipidemia in rats. This study examined oxidative stress status in livers of these same animals. Spectrophotometric analysis of 79 Fischer rat livers (40 female and 39 male) for lipid peroxidation (LPO) and superoxide dismutase (SOD) was conducted using Bioxytech LPO-587(TM) assay kit and SOD-525(Tm) assay kit, respectively. The treatment groups consisted of 20 male CHOW and 19 male FOOD BAR rats and 20 female CHOW and 20 female FOOD BAR rats. Statistical analysis to compare differences between groups was performed by standard analysis of variance procedures. The male FOOD BAR group LPO mean (3.6 +/- 0.2 mmol/g) was significantly (p less than or equal to 0.05) greater than that of the male CHOW group (2.1 +/-0.1 mmol/g). Moreover the female FOOD BAR group LPO mean (2.9 +/-0.1 mmol/g) was also significantly greater than the female CHOW group mean (2.2 +/-0.1 mmol/g). The mean values for SOD in both male and female groups showed no significant differences between CHOW and FOOD BAR groups. These results show that LPO levels were significantly higher in both the male and female FOOD BAR groups compared to CHOW groups and that there was no concomitant increase in SOD levels across the group. In addition, males showed a greater difference than females in terms of LPO levels. These findings suggest a need for further investigation into the use of the current food bar formulation for long-term experiments such as those planned for the ISS.

Diet-induced obesity causes ghrelin resistance in reward processing tasks.

PubMed

Lockie, Sarah H; Dinan, Tara; Lawrence, Andrew J; Spencer, Sarah J; Andrews, Zane B

2015-12-01

Diet-induced obesity (DIO) causes ghrelin resistance in hypothalamic Agouti-related peptide (AgRP) neurons. However, ghrelin promotes feeding through actions at both the hypothalamus and mesolimbic dopamine reward pathways. Therefore, we hypothesized that DIO would also establish ghrelin resistance in the ventral tegmental area (VTA), a major site of dopaminergic cell bodies important in reward processing. We observed reduced sucrose and saccharin consumption in Ghrelin KO vs Ghrelin WT mice. Moreover, DIO reduced saccharin consumption relative to chow-fed controls. These data suggest that the deletion of ghrelin and high fat diet both cause anhedonia. To assess if these are causally related, we tested whether DIO caused ghrelin resistance in a classic model of drug reward, conditioned place preference (CPP). Chow or high fat diet (HFD) mice were conditioned with ghrelin (1mg/kg in 10ml/kg ip) in the presence or absence of food in the conditioning chamber. We observed a CPP to ghrelin in chow-fed mice but not in HFD-fed mice. HFD-fed mice still showed a CPP for cocaine (20mg/kg), indicating that they maintained the ability to develop conditioned behaviour. The absence of food availability during ghrelin conditioning sessions induced a conditioned place aversion, an effect that was still present in both chow and HFD mice. Bilateral intra-VTA ghrelin injection (0.33μg/μl in 0.5μl) robustly increased feeding in both chow-fed and high fat diet (HFD)-fed mice; however, this was correlated with body weight only in the chow-fed mice. Our results suggest that DIO causes ghrelin resistance albeit not directly in the VTA. We suggest there is impaired ghrelin sensitivity in upstream pathways regulating reward pathways, highlighting a functional role for ghrelin linking appropriate metabolic sensing with reward processing. Copyright © 2015 The Authors. Published by Elsevier Ltd.. All rights reserved.

Probiotics modify tight-junction proteins in an animal model of nonalcoholic fatty liver disease

PubMed Central

Briskey, David; Heritage, Mandy; Jaskowski, Lesley-Anne; Peake, Jonathan; Gobe, Glenda; Subramaniam, V. Nathan; Crawford, Darrell; Campbell, Catherine; Vitetta, Luis

2016-01-01

Background: We have investigated the effects of a multispecies probiotic preparation containing a combination of probiotic bacterial genera that included Bifidobacteria, Lactobacilli and a Streptococcus in a mouse model of high-fat diet or obesity-induced liver steatosis. Methods: Three groups of C57B1/6J mice were fed either a standard chow or a high-fat diet for 20 weeks, while a third group was fed a high-fat diet for 10 weeks and then concomitantly administered probiotics for a further 10 weeks. Serum, liver and large bowel samples were collected for analysis. Results: The expression of the tight-junction proteins ZO-1 and ZO-2 was reduced (p < 0.05) in high-fat diet-fed mice compared to chow-fed mice. Probiotic supplementation helped to maintain tight ZO-1 and ZO-2 expression compared with the high-fat diet group (p < 0.05), but did not restore ZO-1 or ZO-2 expression compared with chow-fed mice. Mice fed a high-fat diet ± probiotics had significant steatosis development compared with chow-fed mice (p < 0.05); steatosis was less severe in the probiotics group compared with the high-fat diet group. Hepatic triglyceride concentration was higher in mice fed a high-fat diet ± probiotics compared with the chow group (p < 0.05), and was lower in the probiotics group compared with the high-fat diet group (p < 0.05). Compared with chow-fed mice, serum glucose, cholesterol concentration and the activity of alanine transaminase were higher (p < 0.05), whereas serum triglyceride concentration was lower (p < 0.05) in mice fed a high-fat diet ± probiotics. Conclusions: Supplementation with a multispecies probiotic formulation helped to maintain tight-junction proteins ZO-1 and ZO-2, and reduced hepatic triglyceride concentration compared with a high-fat diet alone. PMID:27366215

Fluid Dynamic Mechanisms and Interactions within Separated Flows and Their Effects on Missile Aerodynamics

DTIC Science & Technology

1983-05-01

Mechanics, Vol. 43, S~ries E, No. 3, September 1976, pp. 387-395. 18. Warpinski , N. R. and Chow, W. L., "Base Pressure Associated With Incompressible...Flow Past Wedges at High Reynolds Numbers," J. of Applied Mechanics, Vol. 46, No. 3, September 1979. 19. Warpinski , N. R. and Chow, W. L., "Viscid

The Nature of the Electron

NASA Astrophysics Data System (ADS)

Lincoln, Don

2016-04-01

Winston Churchill once said of Russia that it was a riddle wrapped in mystery inside an enigma. Were the British Bulldog a physicist, he might have been talking of something other than our Slavic comrades. He might have been talking about an electron.

76 FR 35396 - Notice of Public Information Collection, Request for Comment on the Continued Use of the Partner...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-17

... comments via: E-mail: [email protected] Mail: George Higginbotham, Management Policy Analyst... individuals and/or officers of for-profit and non-profit non-governmental organizations (NGOs) who apply for..., 2011. Lynn Winston, Division Chief, Information and Records Division, Office of Management Services...

Acceleration of Regeneration of Large Gap-Peripheral Nerve Injuries Using Acellular Nerve Allografts Plus Amniotic Fluid Derived Stem Cells (AFS)

DTIC Science & Technology

2015-10-01

amniotic Fluid Derived Stem Cells (AFS). PRINCIPAL INVESTIGATOR: Thomas L. Smith, PhD CONTRACTING ORGANIZATION: Wake Forest University Health Sciences...UNIT NUMBER 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) Wake Forest University Health Sciences Medical Center Boulevard Winston-Salem, NC 27157

International Symposium on Information Technology: Standards for Bibliographic Control (Bangkok, Thailand, September 4-8, 1989).

ERIC Educational Resources Information Center

Thammasat Univ., Bangkok (Thailand). Univ. Libraries.

This document which covers the proceedings of the 1989 International Symposium on Information Technology, begins with several opening ceremony messages and includes the following papers: (1) "Reflections on International Bibliographic Standards" (Winston D. Roberts); (2) "Bibliographic Control from the User's Perspective" (Ruth…

Current Literature in Family Planning, November 1972, No. 51.

ERIC Educational Resources Information Center

Planned Parenthood--World Population, New York, NY. Katherine Dexter McCormick Library.

Abstracts of current publications in the fields of population and family planning are contained in this monthly acquisitions list of the Katherine Dexter McCormick Library, Planned Parenthood, New York. Organized in two parts, Part 1 contains an annotated list of the books most recently acquired by the Library, marked with its Library call number,…

Acquisitions List No. 41, January 1972.

ERIC Educational Resources Information Center

Planned Parenthood--World Population, New York, NY. Katherine Dexter McCormick Library.

The Acquisitions List of demographic books and articles is issued every two months by the Katherine Dexter-McCormick Library. Divided into two parts, the first contains a list of books most recently acquired by the Library, each one annotated and also marked with the Library call number. The second part consists of a list of annotated articles,…

Kiwis in the Collection: The New Zealand Presence in the Published Record

ERIC Educational Resources Information Center

Lavoie, Brian

2014-01-01

Despite its small size and relatively brief national history, New Zealand boasts a distinguished presence in the published record. Authors such as Margaret Mahy and Katherine Mansfield; the renowned soprano Kiri Te Kanawa; and contemporary film icons such as the actor Russell Crowe and producer Peter Jackson are just a few of the well-known names…

Clinical trial studies drug for pediatric diffuse intrinsic pontine glioma (DIPG) treatment | Center for Cancer Research

Cancer.gov

Diffuse intrinsic pontine gliomas (DIPGs) are difficult to treat and are the leading cause of brain tumor deaths in children. Katherine Warren, M.D., of the Pediatric Oncology Branch is leading a pediatric clinical trial to determine the safety and best dose of panobinostat, a histone deacetylase inhibitor, for slowing or stopping the growth of DIPGs. Read more…

New To Teaching: "Vegecating" Children

ERIC Educational Resources Information Center

Bagshaw, Katherine; Barham, Hannah; Betts, Rebecca; Felton, Amie; Knatt, Joshua

2014-01-01

Student teachers, Katherine Bagshaw, Hannah Barham, Rebecca Betts, Amie Felton and Joshua Knatt, share their ideas on how to bridge the gap between statutory and non-statutory guidelines for food and nutrition with 8- to 10-year-olds. The teachers realized the health of children has become a focal point of concern for both parents and education…

Challenge and Change in Appalachia: The Story of Hindman Settlement School.

ERIC Educational Resources Information Center

Stoddart, Jess

Founded in 1902 by Katherine Pettit and May Stone, the Hindman Settlement School in Knott County, Kentucky, grew out of the Progressive movement. During the golden age of the school, 1915-32, the reputation of its academic program, health work, and other settlement activities brought substantial renown and influence to the school and its founders.…

Crossing the Water: Spiritual Growth in "Bridge to Terabithia" and "Lizzie Bright and the Buckminster Boy"

ERIC Educational Resources Information Center

Thomas, Trudelle

2011-01-01

The author analyses two award-winning juvenile novels, "Bridge to Terabithia" by Katherine Paterson and "Lizzie Bright and the Buckminster Boy" by Gary Schmidt. Each novel portrays a deep friendship between a boy and girl who cross a stream (or river) into a world that includes fantasy, play, closeness to nature and animals, and a sense of the…

Rethinking Classroom Participation: Listening to Silent Voices

ERIC Educational Resources Information Center

Schultz, Katherine

2009-01-01

Many educators understand how to gauge learning by paying close attention to student talk. Few know how to interpret and attend to student silence as a form of participation. In her new book, Katherine Schultz examines the complex role student silence can play in teaching and learning. Urging teachers to listen to student silence in new ways, this…

Research Staff | Bioenergy | NREL

Science.gov Websites

-275-4798 Alahuhta, Markus Researcher IV-Molecular Biology Petri.Alahuhta@nrel.gov 303-384-7850 Amore Katherine.Chou@nrel.gov 303-384-7626 Chou, Yat Researcher IV-Molecular Biology Yat.Chen.Chou@nrel.gov 303-384 Emeritus Researcher Helena.Chum@nrel.gov 303-275-4668 Chung, Daehwan Researcher III-Molecular Biology

Ian Falconer and Olivia

ERIC Educational Resources Information Center

Pierpont, Katherine

2006-01-01

Katherine Pierpont tells of the creation and development of the popular children's book, "Olivia Forms a Band," by author/illustrator Ian Falconer. In this story, Olivia, a pig, and her mother, father , and brothers are off to have a picnic and see fireworks. Olivia insists that if there are fireworks, there must be a band, even if she must…

Army ant invasions reveal phylogeographic processes across the Isthmus of Panama.

PubMed

Brady, Seán G

2017-02-01

Female army ants cannot fly, making them very poor dispersers across water barriers. This dependence on terrestrial corridors motivated the investigation by Winston et al. (), published in this issue of Molecular Ecology, into the role of Panamanian isthmus formation in the diversification of Eciton army ants. Complete closure of this isthmus occurred around three million years ago (3 Ma), but it has also been hypothesized that earlier, temporary land connections facilitated additional colonization events between South and Central America over the past 13 million years or more. The phylogenomic and population genomic analyses by Winston et al. () uncovered multiple incursions of Eciton lineages into Central America between 4 and 7 Ma. Their study contributes to a growing body of evidence arguing that transitory land bridges predating 3 Ma supported substantial intercontinental biotic exchange. © 2017 John Wiley & Sons Ltd.

Tufted capuchins (Cebus apella) attribute value to foods and tools during voluntary exchanges with humans.

PubMed

Westergaard, Gregory C; Liv, Chanya; Rocca, Andrea M; Cleveland, Allison; Suomi, Stephen J

2004-01-01

This research examined exchange and value attribution in tufted capuchin monkeys ( Cebus apella). We presented subjects with opportunities to obtain various foods and a tool from an experimenter in exchange for the foods or tool in the subjects' possession. The times elapsed before the first chow biscuits were expelled and/or an exchange took place were recorded as the dependent measures. Laboratory chow biscuits, grapes, apples, and a metal bolt (a tool used to probe for syrup) were used as experimental stimuli. The subjects demonstrated the ability to recognize that exchanges could occur when an experimenter was present with a desirable food. Results indicate that subjects exhibited significant variation in their willingness to barter based upon the types of foods that were both in their possession and presented by the experimenter. Subjects more readily traded chow biscuits for fruit, and more readily traded apples for grapes than grapes for apples. During the exchange of tools and food, the subjects preferred the following in descending order when the probing apparatus was baited with sweet syrup: grapes, metal bolts, and chow biscuits. However when the apparatus was not baited, the values changed to the following in descending order: grapes, chow, and metal bolts. These results indicate that tufted capuchins recognize opportunities to exchange and engage in a simple barter system whereby low-valued foods are readily traded for more highly valued food. Furthermore, these capuchins demonstrate that their value for a tool changes depending upon its utility.

Can stevioside in combination with a soy-based dietary supplement be a new useful treatment of type 2 diabetes? An in vivo study in the diabetic goto-kakizaki rat.

PubMed

Jeppesen, Per B; Dyrskog, Stig E; Agger, Andreas; Gregersen, Soren; Colombo, Michele; Xiao, Jianzhong; Hermansen, Kjeld

2006-01-01

The diterpene glycoside stevioside (SVS) and soy bean protein isolate have both been shown to have beneficial effects in diabetes treatment. As they each show different benefits we investigated whether the combination of both substances shows an improvement in the treatment of diabetes in Goto-Kakizaki (GK) rats. Over the course of 4 wk, the rats were fed with the following four test diets (n = 12 per group): 1. Standard carbohydrate-rich laboratory diet (chow), 2. chow + SVS (0.03 g/kg BW/day), 3. 80% SPI + 20% chow and 4. 80% SPI + 20 % chow + SVS (0.03 g/kg BW/day). At the end of the course conscious rats underwent an intra-arterial glucose tolerance test (IAGTT) (2.0 g glucose/kg BW). Compared to normal chow diet, stevioside in combination with SPI shows the following beneficial effects in GK rats with mild type 2 diabetes: 1. a 56% reduction in plasma glucose (p < 0.001), 2. a 118% increase in first-phase insulin (p < 0.005), 3. a 20% reduction in glucagons (p < 0.05), 4. a 28% reduction in total cholesterol (p < 0.001), 5. a 13% reduction in FFA (p < 0.01), 6. a 49% reduction in TG (p < 0.001) and 7. a 11% reduction in the systolic blood pressure (p < 0.001). In conclusion, the combination of stevioside and SPI has synergistic positive effects on the characteristic features of the metabolic syndrome, i.e. hyperglycemia, hypertension and dyslipidemia.

KENNEDY SPACE CENTER, FLA. - Capt. Winston Scott, executive director of the Florida Space Authority, speaks at a dedication and ribbon-cutting ceremony for the Space Life Sciences Lab hosted by NASA-Kennedy Space Center and the state of Florida at the new lab. Completed in August, the facility encompasses more than 100,000 square feet and was formerly known as the Space Experiment Research and Processing Laboratory or SERPL. The state, through the Florida Space Authority, built the research lab which is host to NASA, NASA’s Life Sciences Services contractor Dynamac Corp., Bionetics Corp., and researchers from the University of Florida. Dynamac Corp. leases the facility. The Florida Space Research Institute is responsible for gaining additional tenants from outside the NASA community.

NASA Image and Video Library

2003-11-19

KENNEDY SPACE CENTER, FLA. - Capt. Winston Scott, executive director of the Florida Space Authority, speaks at a dedication and ribbon-cutting ceremony for the Space Life Sciences Lab hosted by NASA-Kennedy Space Center and the state of Florida at the new lab. Completed in August, the facility encompasses more than 100,000 square feet and was formerly known as the Space Experiment Research and Processing Laboratory or SERPL. The state, through the Florida Space Authority, built the research lab which is host to NASA, NASA’s Life Sciences Services contractor Dynamac Corp., Bionetics Corp., and researchers from the University of Florida. Dynamac Corp. leases the facility. The Florida Space Research Institute is responsible for gaining additional tenants from outside the NASA community.

KENNEDY SPACE CENTER, FLA. - A wreath and other floral arrangements rest beneath the Astronaut Memorial Mirror at the KSC Visitor Complex following a memorial service held for the crew of Columbia on the anniversary of the tragic accident that took their lives Feb. 1, 2003.  In the foreground are a portion of the roses and carnations left by visitors who attended the memorial.  The service included comments by Center Director Jim Kennedy, Deputy Director Woodrow Whitlow Jr., Executive Director of Florida Space Authority Winston Scott, and Dr. Stephen Feldman, president of the Astronaut Memorial Foundation, who placed the wreath at the mirror.  The black granite mirror honors astronauts, whose names are carved in the surface, who have given their lives for space exploration.

NASA Image and Video Library

2004-02-01

KENNEDY SPACE CENTER, FLA. - A wreath and other floral arrangements rest beneath the Astronaut Memorial Mirror at the KSC Visitor Complex following a memorial service held for the crew of Columbia on the anniversary of the tragic accident that took their lives Feb. 1, 2003.  In the foreground are a portion of the roses and carnations left by visitors who attended the memorial.  The service included comments by Center Director Jim Kennedy, Deputy Director Woodrow Whitlow Jr., Executive Director of Florida Space Authority Winston Scott, and Dr. Stephen Feldman, president of the Astronaut Memorial Foundation, who placed the wreath at the mirror.  The black granite mirror honors astronauts, whose names are carved in the surface, who have given their lives for space exploration.

KENNEDY SPACE CENTER, FLA. - At the podium in front of the Space Memorial Mirror at the KSC Visitor Complex is Dr. Stephen Feldman, president of the Astronaut Memorial Foundation. He spoke to attendees at the memorial service remembering and honoring the crew of Columbia. With him (from left) are KSC Deputy Director Woodrow Whitlow Jr., Center Director Jim Kennedy and Executive Director of Florida Space Authority Winston Scott. Feb. 1 is the one-year anniversary of the loss of the crew and orbiter Columbia in a tragic accident as the ship returned to Earth following mission STS-107. Scott is a former astronaut who flew on Columbia in 1997. Attended by many friends, co-workers and families, the memorial service was also open to the public.

NASA Image and Video Library

2004-02-01

KENNEDY SPACE CENTER, FLA. - At the podium in front of the Space Memorial Mirror at the KSC Visitor Complex is Dr. Stephen Feldman, president of the Astronaut Memorial Foundation. He spoke to attendees at the memorial service remembering and honoring the crew of Columbia. With him (from left) are KSC Deputy Director Woodrow Whitlow Jr., Center Director Jim Kennedy and Executive Director of Florida Space Authority Winston Scott. Feb. 1 is the one-year anniversary of the loss of the crew and orbiter Columbia in a tragic accident as the ship returned to Earth following mission STS-107. Scott is a former astronaut who flew on Columbia in 1997. Attended by many friends, co-workers and families, the memorial service was also open to the public.

Student Housing and Residential Life: A Handbook for Professionals Committed to Student Development Goals. The Jossey-Bass Higher and Adult Education Series.

ERIC Educational Resources Information Center

Winston, Roger B., Jr.; And Others

This book on student housing and residential life contains the following articles: (1) "New Challenges and Goals for Residential Life Programs" (Blimling); (2) "Student Development in the Residential Environment" (Winston and Anchors); (3) "Psychosocial Development in College" (White and Porterfield); (4) "Intellectual, Ethical, and Moral…

76 FR 27366 - CEVA Freight, LLC, Dell Logistics Division, Including On-Site Leased Workers From Prologistix...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-11

... Logistics Division, Including On-Site Leased Workers From Prologistix, Including Workers Whose Unemployment..., applicable to workers of CEVA Freight, LLC, Dell Logistics Division, including on-site leased workers from... workers employed at CEVA Freight, LLC, Dell Logistics Division, Winston-Salem, North Carolina who were...

IFLA General Conference, 1989. Introduction to IFLA's Core Programmes; Contributed Papers; Plenary Session Papers. Booklet 00.

ERIC Educational Resources Information Center

International Federation of Library Associations, The Hague (Netherlands).

This collection contains three papers providing an introduction to the International Federation of Library Associations (IFLA) Core Programs, four contributed papers, and two Plenary Session papers: (1) "The Universal Bibliographic Control and International MARC (Machine Readable Cataloging Formats) Program" (Winston D. Roberts); (2) "Le Programme…

78 FR 12267 - Approval and Promulgation of Air Quality Implementation Plans; Charlotte, Raleigh/Durham and...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-22

... maintenance plan update is for the Charlotte, Raleigh/Durham and Winston-Salem carbon monoxide (CO) maintenance areas. Specifically, the State submitted a limited maintenance plan update for CO, showing continued attainment of the 8-hour CO National Ambient Air Quality Standard for the Charlotte, Raleigh...

77 FR 56809 - Foreign-Trade Zone 230-Piedmont Triad Area, North Carolina; Notification of Proposed Production...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-09-14

... Triad Area, North Carolina; Notification of Proposed Production Activity, Sonoco Corrflex (Kitting--Gift... notification of proposed production activity on behalf of Sonoco Corrflex, located in Rural Hall and Winston... hygiene gift sets. Production under FTZ procedures could exempt Sonoco Corrflex from customs duty payments...

Alcelaphine gammaherpesvirus 1-induced malignant catarrhal fever in a Watusi (bos taurus africanus) steer in a North American game park

USDA-ARS?s Scientific Manuscript database

A 10 year-old Watusi (Bos taurus africanus) steer housed at a drive-through game park in Winston, Oregon developed severe clinical illness including: fever, marked nasal discharge, injected scleral and conjunctival membranes, plus oral hemorrhages and erosions. The animal responded poorly to support...

Studies in Teaching.

ERIC Educational Resources Information Center

McCoy, Leah P., Ed.

The 30 papers presented at Wake Forest University's 1997 Annual Research Forum (Winston-Salem, North Carolina) are as follows: "To Sprint or Crawl: The Effect of Classroom Activities on Student Behavior: (R. Allen); "Generating Good Grammar: Traditional and Whole Language Approaches" (D. Alexander); "Effective Teaching…

Innovative Staffing To Meet Technological Changes: A Case Study at Wake Forest University.

ERIC Educational Resources Information Center

Ganzert, Robin Roy; Watkins, Dawn Adele

1997-01-01

Examines the changes surrounding information technology as it relates to staffing issues at Wake Forest University (Winston-Salem, North Carolina). Highlights include: revision of organizational structure; decentralization of human resources processes; a survey of personnel attitudes; and trends for the human resources department. (AEF)

STS-87 Day 03 Highlights

NASA Technical Reports Server (NTRS)

1997-01-01

On this third day of the STS-87 mission, the flight crew, Cmdr. Kevin R. Kregel, Pilot Steven W. Lindsey, Mission Specialists Winston E. Scott, Kalpana Chawla, and Takao Doi, and Payload Specialist Leonid K. Kadenyuk deploy the Spartan satellite with the shuttle's robot arm.

Volunteer Rehabilitation Technology: International Perspectives and Possibilities. Report of a Symposium Sponsored by the RESNA (ICAART) Conference (Montreal, Canada, June 27, 1988). Monograph Number Forty-Two.

ERIC Educational Resources Information Center

Tobias, Jim, Ed.; Woods, Diane E., Ed.

Symposium papers describe programs which use volunteers to provide rehabilitation technology services. George Winston describes Australia's Technical Aid to the Disabled (TAD), focusing on volunteer recruitment and selection, legal liability, volunteer insurance, advantages and limitations of the volunteer approach, and the TAD organization,…

78 FR 34303 - Approval and Promulgation of Implementation Plans; North Carolina; Removal of Stage II Gasoline...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-07

... associated maintenance plans, North Carolina provided contingency measures that included regulation 15A North... contingency measures that were also included in the 1- hour ozone maintenance plans. These contingency... the contingency measures in its SIP for the Charlotte-Gastonia, Greensboro-Winston-Salem-High Point...

78 FR 45181 - Foreign-Trade Zone 230-Piedmont Triad Area, North Carolina, Authorization of Production Activity...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-26

... DEPARTMENT OF COMMERCE Foreign-Trade Zones Board [B-31-2013] Foreign-Trade Zone 230--Piedmont Triad Area, North Carolina, Authorization of Production Activity, Oracle Flexible Packaging, Inc., (Foil... (FTZ) Board on behalf of Oracle Flexible Packaging, Inc., within Site 28, in Winston-Salem, North...

Food intake in laboratory rats provided standard and fenbendazole-supplemented diets.

PubMed

Vento, Peter J; Swartz, Megan E; Martin, Lisa Be; Daniels, Derek

2008-11-01

The benzimidazole anthelmintic fenbendazole (FBZ) is a common and effective treatment for pinworm infestation in laboratory animal colonies. Although many investigators have examined the potential for deleterious biologic effects of FBZ, more subtle aspects of the treatment remain untested. Accordingly, we evaluated differences in food intake when healthy male Sprague-Dawley rats were provided a standard nonmedicated laboratory rodent chow or the same chow supplemented with FBZ. We also tested for a preference for either food type when subjects were provided a choice of the 2 diets. Data from these experiments showed no differences in food intake or body weight when rats were maintained on either standard or FBZ-supplemented chow. When the rats were given access to both the standard and FBZ-supplemented diets, they showed a clear preference for the standard diet. The preference for the standard diet indicates that the rats can discriminate between the 2 foods and may avoid the FBZ-supplemented chow when possible. Investigators conducting experiments during treatment with FBZ in which differences in food preference are relevant should be aware of these data and plan their studies accordingly.

Food Intake in Laboratory Rats Provided Standard and Fenbendazole-supplemented Diets

PubMed Central

Vento, Peter J; Swartz, Meghan E; Martin, Lisa BE; Daniels, Derek

2008-01-01

The benzimidazole anthelmintic fenbendazole (FBZ) is a common and effective treatment for pinworm infestation in laboratory animal colonies. Although many investigators have examined the potential for deleterious biologic effects of FBZ, more subtle aspects of the treatment remain untested. Accordingly, we evaluated differences in food intake when healthy male Sprague–Dawley rats were provided a standard nonmedicated laboratory rodent chow or the same chow supplemented with FBZ. We also tested for a preference for either food type when subjects were provided a choice of the 2 diets. Data from these experiments showed no differences in food intake or body weight when rats were maintained on either standard or FBZ-supplemented chow. When the rats were given access to both the standard and FBZ-supplemented diets, they showed a clear preference for the standard diet. The preference for the standard diet indicates that the rats can discriminate between the 2 foods and may avoid the FBZ-supplemented chow when possible. Investigators conducting experiments during treatment with FBZ in which differences in food preference are relevant should be aware of these data and plan their studies accordingly. PMID:19049253

77 FR 77016 - Authorization of Production Activity: Foreign-Trade Zone 230: Sonoco Corrflex (Kitting-Gift Sets...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-12-31

... DEPARTMENT OF COMMERCE Foreign-Trade Zones Board [B-69-2012] Authorization of Production Activity: Foreign-Trade Zone 230: Sonoco Corrflex (Kitting-Gift Sets); Rural Hall and Winston-Salem, North Carolina On August 20, 2012, the Piedmont Triad Partnership, grantee of FTZ 230, submitted a notification of...

Planned Change in Teacher Education: Unfreezing the Status Quo through the Integration of Technology.

ERIC Educational Resources Information Center

Bell, Edwin D.; Ireh, Madu

This study examined planned change in Winston-Salem State University's teacher education program. An external review of the School of Education indicated a weakness in program planning and curriculum design. This review stimulated planned change initiative to strengthen teacher education. Factors influencing the internal environment of teacher…

12. HISTORICAL VIEW OF FRONT ENTRANCE, BEFORE ADDITION OF SHELTERED ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

12. HISTORICAL VIEW OF FRONT ENTRANCE, BEFORE ADDITION OF SHELTERED PORCH, SOUTH ELEVATION, 1907. Photocopied from Henry Pleasants's book, History of Old St. David's Church, published in 1915 by John C. Winston Co. - St. David's Church (Episcopal), Valley Forge Road (Newtown Township), Wayne, Delaware County, PA

Active Touch Sensing

DTIC Science & Technology

1981-04-01

Marvin Minsky . -36- 1. Broit, M. The Utilization of" an "Artificial Skin" sensor for the Identification of Solid Objects. Proc. 9th lnL Symp. on...Dertouzos, Ed Hardebeck, Henry Minsky , Margaret Minsky , Lisa Schostakovich, Laurel Simmons, Latanya Sweeney. Patrick Winston and most importantly

Supervising Graduate Assistants

ERIC Educational Resources Information Center

White, Jessica; Nonnamaker, John

2011-01-01

Discussions of personnel management in student affairs literature and at national conferences often focus on supervising new or midlevel professionals and the myriad challenges and possibilities these relationships entail (Carpenter, 2001; Winston and Creamer, 1997). Graduate students as employees and the often-complicated and ill-structured…

Aesthetic Learning Theory and the Faith Formation of Young Adults

ERIC Educational Resources Information Center

Douglass, Katherine M.

2013-01-01

Participation in the arts is a form of practical reason and as such has the potential to form and transform the faith of individuals. The findings from Katherine M. Douglass's 2011 study on the role of the arts in the faith lives of young adults provides examples of the transformative potential of the arts as they foster expression,…

The Impact of Conflicting Spatial Representations in Airborne Unmanned Aerial System Sensor Control

DTIC Science & Technology

2016-02-01

Spatial Discordance 1 Running head: SPATIAL DISCORDANCE IN AIRBORNE UAS OPERATIONS The impact of conflicting spatial...representations in airborne unmanned aerial system sensor control Joseph W Geeseman, James E Patrey, Caroline Davy, Katherine Peditto, & Christine Zernickow...system (UAS) simulation while riding in the fuselage of an airborne Lockheed P-3 Orion. The P-3 flew a flight profile of intermittent ascending

Identification of Challenges and Opportunities for Regional Sediment Management (RSM) and Engineering with Nature (EWN) within Inland USACE Districts

DTIC Science & Technology

2016-07-01

sediment dredging activities in support of navigation channel maintenance with resultant direct beach placement or nearshore placement were common...watershed and stream channel erosion prevention. • Identify sediment resources and flux in and out of the flood plain and create sediment budgets...Regional Sediment Management (RSM) and Engineering With Nature (EWN) within Inland USACE Districts by Katherine Touzinsky, Paul Boyd, and John

NREL Taps Young to Oversee Geothermal Energy Program | News | NREL

Science.gov Websites

Taps Young to Oversee Geothermal Energy Program News Release: NREL Taps Young to Oversee Geothermal (NREL) promoted Katherine Young to laboratory program manager for geothermal energy. Young has been with NREL since 2008, working as a senior geothermal analyst and engineer in the Strategic Energy Analysis

Demonstration of Removal, Separation, and Recovery of Heavy Metals from Industrial Wastestreams Using Molecular Recognition Technology (MRT)

DTIC Science & Technology

2002-11-01

Treatment Plant”, TM-2123-ENV, April 1995. 3. Ford, K.H., 1996, “ Heavy Metal Adsorption/ Biosorption Studies for Zero Discharge Industrial Wastewater...SEPARATION, AND RECOVERY OF HEAVY METALS FROM INDUSTRIAL WASTESTREAMS USING MOLECULAR RECOGNITION TECHNOLOGY (MRT) Final Report by Dr. Katherine...GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER DEMONSTRATION OF REMOVAL, SEPARATION, AND RECOVERY OF HEAVY METALS FROM INDUSTRIAL WASTEWATERS USING

High intake of palatable food predicts binge-eating independent of susceptibility to obesity: an animal model of lean vs obese binge-eating and obesity with and without binge-eating.

PubMed

Boggiano, M M; Artiga, A I; Pritchett, C E; Chandler-Laney, P C; Smith, M L; Eldridge, A J

2007-09-01

To determine the stability of individual differences in non-nutritive 'junk' palatable food (PF) intake in rats; assess the relationship of these differences to binge-eating characteristics and susceptibility to obesity; and evaluate the practicality of using these differences to model binge-eating and obesity. Binge-eating prone (BEP) and resistant (BER) groups were identified. Differential responses to stress, hunger, macronutrient-varied PFs, a diet-induced obesity (DIO) regimen and daily vs intermittent access to a PF+chow diet, were assessed. One hundred and twenty female Sprague-Dawley rats. Reliability of intake patterns within rats; food intake and body weight after various challenges over acute (1, 2, 4 h), 24-h and 2-week periods. Although BEP and BER rats did not differ in amount of chow consumed, BEPs consumed >50% more intermittent PF than BERs (P<0.001) and consistently so (alpha=0.86). BEPs suppressed chow but not PF intake when stressed, and ate as much when sated as when hungry. Conversely, BERs were more affected by stress and ate less PF, not chow, when stressed and were normally hyperphagic to energy deficit. BEP overeating generalized to other PFs varying in sucrose, fat and nutrition content. Half the rats in each group proved to be obesity prone after a no-choice high fat diet (DIO diet) but a continuous diet of PF+chow normalized the BEPs high drive for PF. Greater intermittent intake of PF predicts binge-eating independent of susceptibility to weight gain. Daily fat consumption in a nutritious source (DIO-diet; analogous to a fatty meal) promoted overeating and weight gain but limiting fat to daily non-nutritive food (PF+chow; analogous to a snack with a low fat meal), did not. The data offer an animal model of lean and obese binge-eating, and obesity with and without binge-eating that can be used to identify the unique physiology of these groups and henceforth suggest more specifically targeted treatments for binge-eating and obesity.

Bereday and Hilker: Origins of the "Four Steps of Comparison" Model

ERIC Educational Resources Information Center

Adick, Christel

2018-01-01

The article draws attention to the forgotten ancestry of the "four steps of comparison" model (description--interpretation--juxtaposition--comparison). Comparativists largely attribute this to George Z. F. Bereday [1964. "Comparative Method in Education." New York: Holt, Rinehart and Winston], but among German scholars, it is…

Bike Skills Training in PE Is Fun, Keeps Kids Safe

ERIC Educational Resources Information Center

Wallace, Judi Lawson; Sutton, Nancy P.

2015-01-01

Incorporating bike skills into the elementary- and middle-school physical education curriculum encourages students to be physically active in a fun way while also learning bike safety skills. Winston-Salem's (NC) Safe Routes to School program demonstrates how collaboration with the public schools' health and physical education program can…

Continuing the Struggle.

ERIC Educational Resources Information Center

Nelson, Corinne O.

1997-01-01

Reports on the Third National Conference of African American Librarians held in Winston-Salem, North Carolina, July 31-August 3, 1997. Discusses affirmative action; traditionally black colleges; the recruitment of African Americans to librarianship; equitable job opportunities; children; loss of jobs to technology; authors and other notables; and…

Structure of an urban Christmas tree market

Treesearch

Thomas H. Pendleton; Lawrence D. Garrett; Lawrence D. Garrett

1973-01-01

The retail Christmas tree market in Winston-Salem, N.C., was studied 3 years. Types of retailers and their sales are described. Best sales were made by dealers who had lots on heavily traveled streets in business districts, had ample parking facilities, advertised, and displayed their trees well.

13. HISTORICAL VIEW OF NAVE AND ALTAR, LOOKING NORTH, 1907. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

13. HISTORICAL VIEW OF NAVE AND ALTAR, LOOKING NORTH, 1907. (Altar was at east end originally). Photocopied from Henry Pleasants's book, History of Old St. David's Church, published in 1915 by John C. Winston Co. - St. David's Church (Episcopal), Valley Forge Road (Newtown Township), Wayne, Delaware County, PA

STRAIN-DEPENDENT SUSCEPTIBILITY TO TRANSPLACENTALLY-INDUCED MURINE LUNG TUMORS

EPA Science Inventory

STRAIN-DEPENDENT SUSCEPTIBILITY TO TRANSPLACENTALLY-INDUCED MURINE LUNG TUMORS
M S Miller, J E Moore, M Xu, G B Nelson, S T Dance, N D Kock, J A Ross Wake Forest University, Winston-Salem, NC and USEPA, Research Triangle Park, NC

Previously, our laboratory demonstrated...

Wake Forest U. Joins Ranks of Test-Optional Colleges

ERIC Educational Resources Information Center

Hoover, Eric; Supiano, Beckie

2008-01-01

Wake Forest University will no longer require applicants to submit standardized test scores, the university announced last week. The move makes Wake Forest, in Winston-Salem, North Carolina, one of the most prominent institutions with a "test optional" admissions policy. The university's decision reveals the increasing complexity of the…

A Diversity of Grammars: Breaking the Boundaries of "The Well Made Box."

ERIC Educational Resources Information Center

Sidler, Michelle

In his 1976 article, "Grammars of Style: New Options in Composition," Winston Weathers calls for a Grammar B, an alternate set of conventions which govern the construction of whole compositions. He urges compositionists to look beyond the "well-made box" and consider other options for compositional patterns and discourse…

Harry S. Truman Dam and Reservoir, Missouri, Holocene Adaptations Within the Lower Pomme de Terre River Valley, Missouri. Volume 2.

DTIC Science & Technology

1982-06-01

B. 1966 Quantitative analysis of Upper Paleolithic stone tools. American Antiquity 68(2-2) :356-394. Scully, E. G. 1951 Some central Mississippi...Programming for the Social Sciences. Holt, Rinehart and Winston, New York. White, A. M. 1973 Le Malpas Rockshelter: a study of late Paleolithic technology in

Taking Care of Business: Bridging the Skills Gap

ERIC Educational Resources Information Center

Gatewood, Algie

2017-01-01

This brief article describes how Alamance Community College, a mid-sized community college sandwiched between two of North Carolina's largest metropolitan markets in Raleigh-Durham and Greensboro-Winston-Salem, has developed several new study programs and initiatives to better service business and industry. Among other things, Almanac has…

Coastal Foredune Evolution, Part 2: Modeling Approaches for Meso-Scale Morphologic Evolution

DTIC Science & Technology

2017-03-01

ERDC/CHL CHETN-II-57 March 2017 Approved for public release; distribution is unlimited. Coastal Foredune Evolution, Part 2: Modeling Approaches...for Meso-Scale Morphologic Evolution by Margaret L. Palmsten1, Katherine L. Brodie2, and Nicholas J. Spore2 PURPOSE: This Coastal and Hydraulics...Engineering Technical Note (CHETN) is the second of two CHETNs focused on improving technologies to forecast coastal foredune evolution. Part 1

Longevity of Single-Tooth All-Ceramic CAD/CAM Restorations: A Meta-Analysis

DTIC Science & Technology

2013-07-01

A thesis submitted to the Faculty of the Comprehensive Dentistry Graduate Program Naval Postgraduate Dental School Uniformed Services...Naval Postgraduate Dental School Uniformed Services University of the Health Sciences Bethesda, Maryland CERTIFICATE OF APPROVAL MASTER’S THESIS...This is to certify that the Master’s thesis of Katherine L. Cheng Lieutenant, Dental Corps, U.S. Navy has been approved by the Examining Committee for

Disrupting Illicit Small Arms Trafficking in the Middle East

DTIC Science & Technology

2008-12-01

personal use and light weapons as weapons designed for use by a crew. Small arms include revolvers, self-loading pistols, rifles, sub- machine guns...assault rifles, and light machine guns. Light weapons include machine -guns, mortars, hand grenades, grenade launchers, portable anti-aircraft guns...71 David Atwood , Anne-Katherin Glatz, and Robert Muggah, Demanding Attention: Addressing the Dynamics of Small Arms Demand (Geneva: Small Arms

Educational and Nonprofit Institutions Receiving Prime Contract Awards for RDT&E (Research, Development, Test and Evaluation), Fiscal Year 1975.

DTIC Science & Technology

1975-01-01

i 9 CHAPEL HILL WARE ,’ WILMINGON HCAR so PENNSYLVANIA UNIVERSITY Of 2 1 FNILAOELPNIA Pfa 1 NORTN OAK"TA UNIVERSITY OF in S GRANO FOPKS NOAK • PETER...MAKE FOREST UNIVERSITY * *- *WINSTON SALEM NCAR i TEXAS CHRISTIAN UNIVERSITY ZZ FORT WORTH TEXAS 77 * WASHINGTON STATE UNIVERSITY * .* T XAS

78 FR 67129 - Procurement List; Additions

Federal Register 2010, 2011, 2012, 2013, 2014

2013-11-08

... for the Blind, Inc., Winston-Salem, NC. Contracting Activity: DEFENSE COMMISSARY AGENCY, FORT LEE, VA. COVERAGE: C-List for the requirements of military commissaries and exchanges as aggregated by the Defense..., Wall, Self-Set Movement, 14.5''. NSN: 6645-00-NIB-0145--Clock, Wall, Quartz Movement, 16.5''. NSN: 6645...

Effects of a College Adventure Orientation Program on Student Development Behaviors

ERIC Educational Resources Information Center

Vlamis, Ekaterini; Bell, Brent J.; Gass, Michael

2011-01-01

This study examined the effects of an adventure orientation program on the student development behaviors of incoming first-year students at Hartwick College in Oneonta, New York. Student development was measured by a condensed version of the Student Development Task Inventory-2 (CSDTI-2; Gass, 1986; Winston, Miller, & Prince, 1979). Data…

Long term storage of bee semen – A six month assessment of cryopreserved semen quality using motility as an index

USDA-ARS?s Scientific Manuscript database

Bee (Apis mellifera Linn.) spermatozoa is known for its ability to remain viable for at the least two years within the spermatheca as attested to by the queens’ continued laying of fertile eggs without remating over two to three (Woyke 1960; Winston 1987). However, the semen collected from the dron...

The Relationship between Financial Resources and Graduation Rates at Public Colleges and Universities

ERIC Educational Resources Information Center

Harris, Kimberly Nicole

2011-01-01

The purpose of this study is to examine the relationship between public HEI's fiscal resources and student persistence to degree completion. Consequently, building upon the studies of researchers such as Titus (2006a, 2006b), Hearn (2003a, 2003b), and Winston (1999), this study investigates the relationships between institutional organizations…

Information Processing Analysis of Visual Perception: A Review

DTIC Science & Technology

1974-06-01

cartoon ( Wittgenstein ,!953), and Boring’s Young Woman/Old Hag (Boring.l 942) drawing, as well as examples of figure-ground confusions which are all...8217, New York. WINSTON,^ (1970) ’Learning Structural Descripi,ons from Examples’, MIT Al i.ab. WITTGENSTEIN , L.W. (1 953) ’Philosophical Investigations

Evaluation of a Cultural Competence Intervention with Implications for the Nurse-Patient Encounter

ERIC Educational Resources Information Center

Bradford, Althea Betty

2012-01-01

A short-term intervention on participants' knowledge of cultural competence was provided to 38 students in a baccalaureate nursing program at Winston-Salem State University (WSSU). The study examined the effectiveness of this intervention. Although WSSU is a Historically Black University, the majority of students in this program were White. Six…

Perceptions of Quality of Nursing Care: Patients and Registered Nurses in a Hospital Using 12-Hour Shifts.

DTIC Science & Technology

1983-01-01

Kollat, D. T., & Blackwell, R. D. Consumer behavior . New York: Holt, Rinehart, & Winston, 1968. Ganong, W. L., Ganong, J. M., & Harrison, E. T. The 12-hour...Administration, 1982, 12(1), 11-14. " . Walters, C. G., & Paul, G. W. Consumer behavior an integrated framework. Homewood, Ii.: Irwin, 1970. Wandelt, M. A

STRAIN-DEPENDENT SUSCEPTIBILITY TO TRANSPLACENTALLY-INDUCED MURINE LUNG TUMORS AND DNA ADDUCTS OF 3-METHYLCHOLANTHRENE

EPA Science Inventory

Strain-dependent susceptibility to transplacentally-induced murine lung tumors and DNA adducts of 3methylcholanthrene G B Nelson, J A Ross, J E Moore, M Xu, N D Kock, M S Miller Wake Forest University, Winston-Salem, NC and USEPA, Research Triangle Park, NC.

It has been de...

NLRB v. Yeshiva University: The End of Faculty Unions?

ERIC Educational Resources Information Center

Gergacz, John William; Krider, Charles E.

1980-01-01

A controversy over whether university faculty are "employees" within the meaning of the National Labor Relations Act is discussed. The U.S. Supreme Court in NLRB v. Yeshiva University ruled that faculty members are "managers." (Available from: Wake Forest University School of Law, Winston-Salem, NC 27109, $4.00) (Author/MLW)

STS-87 Day 05 Highlights

NASA Technical Reports Server (NTRS)

1997-01-01

On this fifth day of the STS-87 mission, the flight crew, Cmdr. Kevin R. Kregel, Pilot Steven W. Lindsey, Mission Specialists Winston E. Scott, Kalpana Chawla, and Takao Doi, and Payload Specialist Leonid K. Kadenyuk continue experimental work aboard Columbia. Leonid Kadenyuk focuses on studies of plant growth in weightlessness.

Contemporary Issues in Cognitive Psychology: The Loyola Symposium.

ERIC Educational Resources Information Center

Solso, Robert L. , Ed.

Contributions in the first section of this volume are: "Learning to Identify Toy Block Structures" by Patrick Winston; "Beyond the Yellow-Volkswagen Detector and the Grandmother Cell: A General Strategy for the Exploration of Operations in Human Pattern Recognition" by Naomi Weisstein; "Visual Recognition in a Theory of Information Processing" by…

Effects of diet and exposure to hindlimb suspension on estrous cycling in Sprague-Dawley rats

NASA Technical Reports Server (NTRS)

Tou, Janet C L.; Grindeland, Richard E.; Wade, Charles E.

2004-01-01

Various factors can disrupt the female reproductive cycle resulting in subfertility. The primary objective of this study was to determine whether physiological changes associated with exposure to hypogravity disrupt reproductive cycles. The hindlimb suspension (HLS) model was used to simulate the major physiological effects of hypogravity in female Sprague-Dawley rats. Also, to determine whether diet may influence reproductive results, rats were fed purified American Institute of Nutrition (AIN)-93G or chow diet. Rats (n = 9-11/group) subjected to HLS had lengthened estrous cycles due to prolonged diestrus, indicating hypoestrogenism. Interestingly, HLS rats fed AIN-93G but not chow diet had significantly reduced time spent in estrus and decreased plasma estradiol. Attenuation of hypoestrogenism in the chow-fed rats suggested that diet provided an exogenous source of estrogen. The mechanism involved in the disruption of estrous cycling remains to be determined. HLS increased urinary corticosterone (CORT) levels during the initial 4 days of HLS, suggesting that physiological responses to acute stress may be a potential mechanism in the disruption of estrous cycles. Higher basal urinary CORT was observed in rats fed chow vs. AIN-93G diet. HLS resulted in increased urinary CORT. However, two-way ANOVA indicated a significant HLS effect (P < 0.001) but no effect of HLS x diet effect on urinary CORT levels, suggesting that estrogenic activity associated with the chow diet did not enhance the stress response. The results of this study indicate that HLS, diet, and the combination of HLS and diet influence estrous cycling. This has important implications for future reproductive success in the hypogravity environment of space.

Extended vs. brief intermittent access to palatable food differently promote binge-like intake, rejection of less preferred food, and weight cycling in female rats.

PubMed

Kreisler, A D; Garcia, M G; Spierling, S R; Hui, B E; Zorrilla, E P

2017-08-01

Palatable food access promotes obesity leading some to diet. Here, we modeled the roles of duration, intermittency and choice of access in bingeing, escalation of daily intake, and underacceptance of alternatives. Female rats with ("Choice") or without continuous chow access, received chow or continuous (Chocolate), intermittent (MWF) long (24h, Int-Long), or intermittent short (30min, Int-Short) access to a sucrose-rich, chocolate-flavored diet (CHOC). Int-Long rats showed cycling body weight; they overate CHOC, had increased feed efficiency on access days and underate chow and lost weight on non-access days, the latter correlating with their reduced brown fat. Int-Short rats had the greatest 30-min intake upon CHOC access, but did not underaccept chow or weight cycle. Individual vulnerability for intermittent access-induced feeding adaptations was seen. Continuous access rats gained fat disproportionate, but in direct relation, to their normalized energy intake and persistently underaccepted chow despite abstinence and return to normal weight. Abstinence reduced the binge-like CHOC intake of Int-Short rats and increased that of continuous access rats, but not to levels associated with intermittent access history. Choice increased daily CHOC intake under Continuous access and binge-like intake under Int-Short access. Intermittency and duration of past access to palatable food have dissociable, individually-vulnerable influences on its intake and that of alternatives. With extended access, daily intake reflects the palatability of available food, rather than metabolic need. Ongoing restrictedness of access or a history of intermittency each drive binge-like intake. Aspects of palatable food availability, similar and different to drug availability, promote disordered eating. Copyright © 2017 Elsevier Inc. All rights reserved.

Effect of palatable hyperlipidic diet on lipid metabolism of sedentary and exercised rats.

PubMed

Estadella, Debora; Oyama, Lila M; Dâmaso, Ana R; Ribeiro, Eliane B; Oller Do Nascimento, Claudia M

2004-02-01

The present study was designed to examine 1) whether continuous feeding with a palatable hyperlipidic diet and cycling this diet with chow diet would affect lipid and carbohydrate metabolism in a similar way; and 2) whether the effect of chronic exercise on lipid and carbohydrate metabolism would be modified by these diet regimens. Male 25-d-old Wistar rats were assigned to one of six groups: sedentary rats fed with chow diet; exercised (swimming 90 min/d, 5 d/wk) rats fed with chow diet; sedentary rats fed with a palatable hyperlipidic diet; exercised rats fed with the palatable hyperlipidic diet; sedentary rats fed with food cycles (four cycles alternating the chow and hyperlipidic diets weekly); and exercised rats fed with food cycles. After 8 wk of treatment, the animals were killed 24 h after the last exercise session. The hyperlipidic diet and food cycles schedules caused similar increases in body weight gain, carcass lipogenesis rate and adiposity, lipid content of the liver and gastrocnemius muscle, and serum total lipid, triacylglycerol, insulin, and leptin levels. The exercise attenuated body weight gain, adipose tissue mass, and serum triacylglycerol, insulin, and leptin levels similarly in the hyperlipidic and food cycles groups. Carcass lipogenesis rate was not affected by exercise in any of the three groups. The data showed that the continuous intake of a hyperlipidic palatable diet for 8 wk and the alternation of the high-fat intake with periods of chow intake cause obesity and affected lipid metabolism in a similar way. Chronic exercise attenuated body weight gain and adiposity and improved serum lipid concentrations in both high-fat feeding regimens.

Characterizing and Quantifying Local and Regional Particulate Matter Emissions from Department of Defense Installations

DTIC Science & Technology

2005-03-01

region (Fig. 4.1). A summary of the annual and seasonal average temperature, precipitation , and wind conditions for El Paso is presented in Table 4.1... Precipitation (cm) 2 Average Wind Speed 2 (km/hr) Prevailing Wind Direction 2 (degrees) Annual 17.3 22.4 14.2 360 Winter (Dec...Chow, 2001; Chow et al., 2003). The Teflon-membrane filters were analyzed for mass by gravimetry using a Cahn 31 Electro-microbalance and for 40

Development of a Pilot Career Cluster Curriculum for all Students in a College Preparatory Oriented High School. Final Report. Part I: Curriculum Development.

ERIC Educational Resources Information Center

Montgomery County Public Schools, Rockville, MD.

In developing a program to assist the individual student to plan a goal-oriented program and increase his opportunities both to select courses moving him toward his personal goals and to use the community resources as supplemental educational experiences, the Winston Churchill High School designed a Career Cluster Curriculum Project, the first…

THE READABILITY OF SCIENCE TEXTBOOKS FOR ELEMENTARY SCHOOL.

ERIC Educational Resources Information Center

NEWPORT, JOHN F.

AN INVESTIGATION WAS MADE OF THE READABILITY LEVELS OF NINE CONTINUOUS SERIES OF ELEMENTARY SCHOOL SCIENCE TEXTBOOKS, GRADES 1-6. THE FOLLOWING SCIENCE SERIES WERE EVALUATED--ALLYN AND BACON, AMERICAN BOOK COMPANY, GINN, HARPER AND ROW, HEATH, LYONS AND CARNAHAN, MACMILLAN, SINGER, AND WINSTON. THE SPACHE FORMULA (SAFIER METHOD) WAS APPLIED TO…

Energy Education in Elementary Social Studies. Holt Databank System.

ERIC Educational Resources Information Center

Minnesota State Energy Agency, St. Paul.

This document provides elementary teachers with an annotated index according to grade levels 1-6 of energy education topics in the "Holt Databank System" (Holt, Rinehart and Winston), followed by suggestions for activities related to the topics. Indexed topics, which comprise a major portion of the document, include basic energy information,…

Determining the Simplest Formula of a Compound.

ERIC Educational Resources Information Center

Lee, David T.

1983-01-01

Describes a modified version of an experiment found in the laboratory manual "Chemistry" by Masterton, Slowinski, and Wolford (Holt, Rinehart and Winston, 1980). Accurate results (normally less than four percent error) in less time were achieved when magnesium turnings were used instead of magnesium ribbon called for in the original experiment.…

76 FR 29797 - Westpoint Home, Inc., New York Corporate Sales Office, New York, NY, Including Employees Working...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-05-23

...,218B, TA-W-74,218C, TA-W-74,218D] Westpoint Home, Inc., New York Corporate Sales Office, New York, NY... Home, Inc., Plano, TX Sales Office, Plano, TX; Westpoint Home, Inc., Daleville, IN Sales Office, Daleville, IN; Westpoint Home, Inc., Rogers, AR Sales Office, Rogers, AR; Westpoint Home, Inc., Winston...

Adolescents' Responses to Cigarette Advertisements for Five "Youth Brands" and One "Adult Brand."

ERIC Educational Resources Information Center

Arnett, Jeffrey Jensen

2001-01-01

Examined 12- to 17-year-olds' responses to cigarette advertisements. Found that a substantial proportion of adolescents, especially smokers, liked ads for youth brands and believed they made smoking more appealing. Ads for Marlboro brand and new Camel and Winston ads were especially attractive to adolescents. Few adolescents liked the adult brand…

Reading Rate and Comprehension

ERIC Educational Resources Information Center

Jodai, Hojat

2011-01-01

Reading fluency is one of the most important signs of language proficiency both for native and foreign language speakers (Grabe, 2010; Macalister, 2010; Winston, 2010; Hasbrouck, 2008; Rasinski, 2004; Oakley, 2003; Waldman, 1985; Cited in: Sayenko, 2010, Introduction Para 1). This paper is in the area of reading fluency and tries to investigate…

Micrographics: A Quarter-Century Perspective.

ERIC Educational Resources Information Center

Ach, William K.

2000-01-01

Discusses the uses of micrographics in higher education, based on a 25-year period at Wake Forest University's (Winston-Salem, North Carolina) Library. Discusses acquisition of scholarly collections in microform on a subscription plan; the trend away from microopaques to microfiche and the advent of the reader-printer; improved access to microform…

Understanding the Depth and Richness of the Cultural Context in Career Counseling through the Cultural Formulation Approach (CFA)

ERIC Educational Resources Information Center

Heppner, Mary J.; Fu, Chu-Chun

2010-01-01

In this article, the authors discuss the Cultural Formulation Approach (CFA) proposed by Leong and his colleagues, and the strong and insightful applications of the approach offered by Leong, Arthur, Juntunen, Byars-Winston, and Flores. They think this model has phenomenal possibilities in providing a methodology for counselors to be able to…

A Longitudinal Study of Chickering and Reisser's Vectors: Exploring Gender Differences and Implications for Refining the Theory

ERIC Educational Resources Information Center

Foubert, John; Nixon, Monica; Sisson, V. Shamim; Barnes, Amy C.

2005-01-01

A racially mixed random sample of 247 students at a midsized public university in the Southeast completed the Student Development Task and Lifestyle Inventory at the beginning of their first year, beginning of their sophomore year, and end of their senior year (Winston, Miller & Prince, 1987). Results showed partial support of Chickering and…

Case-Based Policy and Goal Recognition

DTIC Science & Technology

2015-09-30

or noisy. Ontanón et al. [8] use case-based reasoning (CBR) to model human driving vehicle control behaviors and skill level to reduce teen crash...Snodgrass, S., Bonfiglio, D., Winston, F.K., McDonald, C., Gonzalez, A.J.: Case-based prediction of teen driver behavior and skill. In: Pro- ceedings

The Effects of Professional Development on the Knowledge, Attitudes, & Anxiety of Intermediate Teachers of Mathematics

ERIC Educational Resources Information Center

McCartney, Kathleen Perry

2013-01-01

This study examined the effects of a short-term professional development on the mathematical knowledge, anxiety, and attitudes of intermediate teachers. Participants in the control and experimental groups were pre-tested for knowledge using the eighth grade TCAP Item Sampler. Anxiety was measured through the use of Suinn and Winston's (2003)…

Metrics, The Measure of Your Future: Materials Evaluation Forms.

ERIC Educational Resources Information Center

Troy, Joan B.

Three evaluation forms are contained in this publication by the Winston-Salem/Forsyth Metric Education Project to be used in conjunction with their materials. They are: (1) Field-Test Materials Evaluation Form; (2) Student Materials Evaluation Form; and (3) Composite Materials Evaluation Form. The questions in these forms are phrased so they can…

KENNEDY SPACE CENTER, FLA. - At the Space Memorial Mirror in the KSC Visitor Complex, visitors gather around dancers from the Shoshone-Bannock Native American community, Fort Hall, Idaho, who are performing a healing ceremony during the memorial service held for the crew of Columbia. Feb. 1 is the one-year anniversary of the loss of the crew and orbiter Columbia in a tragic accident as the ship returned to Earth following mission STS-107. Students and staff of the Shoshone-Bannock Nation had an experiment on board Columbia. The public was invited to the memorial service, held in the KSC Visitor Complex, which included comments by Center Director Jim Kennedy and Executive Director of Florida Space Authority Winston Scott. Scott is a former astronaut who flew on Columbia in 1997.

NASA Image and Video Library

2004-02-01

KENNEDY SPACE CENTER, FLA. - At the Space Memorial Mirror in the KSC Visitor Complex, visitors gather around dancers from the Shoshone-Bannock Native American community, Fort Hall, Idaho, who are performing a healing ceremony during the memorial service held for the crew of Columbia. Feb. 1 is the one-year anniversary of the loss of the crew and orbiter Columbia in a tragic accident as the ship returned to Earth following mission STS-107. Students and staff of the Shoshone-Bannock Nation had an experiment on board Columbia. The public was invited to the memorial service, held in the KSC Visitor Complex, which included comments by Center Director Jim Kennedy and Executive Director of Florida Space Authority Winston Scott. Scott is a former astronaut who flew on Columbia in 1997.

Small Molecular Inhibitor of Transforming Growth Factor-{beta} Protects Against Development of Radiation-Induced Lung Injury

DOE Office of Scientific and Technical Information (OSTI.GOV)

Anscher, Mitchell S.; Thrasher, Bradley; Zgonjanin, Larisa

2008-07-01

Purpose: To determine whether an anti-transforming growth factor-{beta} (TGF-{beta}) type 1 receptor inhibitor (SM16) can prevent radiation-induced lung injury. Methods and Materials: One fraction of 28 Gy or sham radiotherapy (RT) was administered to the right hemithorax of Sprague-Dawley rats. SM16 was administered in the rat chow (0.07 g/kg or 0.15 g/kg) beginning 7 days before RT. The rats were divided into eight groups: group 1, control chow; group 2, SM16, 0.07 g/kg; group 3, SM16, 0.15 g/kg; group 4, RT plus control chow; group 5, RT plus SM16, 0.07 g/kg; group 6, RT plus SM16, 0.15 g/kg; group 7,more » RT plus 3 weeks of SM16 0.07 g/kg followed by control chow; and group 8, RT plus 3 weeks of SM16 0.15 g/kg followed by control chow. The breathing frequencies, presence of inflammation/fibrosis, activation of macrophages, and expression/activation of TGF-{beta} were assessed. Results: The breathing frequencies in the RT plus SM16 0.15 g/kg were significantly lower than the RT plus control chow from Weeks 10-22 (p <0.05). The breathing frequencies in the RT plus SM16 0.07 g/kg group were significantly lower only at Weeks 10, 14, and 20. At 26 weeks after RT, the RT plus SM16 0.15 g/kg group experienced a significant decrease in lung fibrosis (p = 0.016), inflammatory response (p = 0.006), and TGF-{beta}1 activity (p = 0.011). No significant reduction was found in these measures of lung injury in the group that received SM16 0.7g/kg nor for the short-course (3 weeks) SM16 at either dose level. Conclusion: SM16 at a dose of 0.15 g/kg reduced functional lung damage, morphologic changes, inflammatory response, and activation of TGF-{beta} at 26 weeks after RT. The data suggest a dose response and also suggest the superiority of long-term vs. short-term dosing.« less

Obesity impairs skeletal muscle AMPK signaling during exercise: role of AMPKα2 in the regulation of exercise capacity in vivo.

PubMed

Lee-Young, R S; Ayala, J E; Fueger, P T; Mayes, W H; Kang, L; Wasserman, D H

2011-07-01

Skeletal muscle AMP-activated protein kinase (AMPK)α2 activity is impaired in obese, insulin-resistant individuals during exercise. We determined whether this defect contributes to the metabolic dysregulation and reduced exercise capacity observed in the obese state. C57BL/6J wild-type (WT) mice and/or mice expressing a kinase dead AMPKα2 subunit in skeletal muscle (α2-KD) were fed chow or high-fat (HF) diets from 3 to 16 weeks of age. At 15 weeks, mice performed an exercise stress test to determine exercise capacity. In WT mice, muscle glucose uptake and skeletal muscle AMPKα2 activity was assessed in chronically catheterized mice (carotid artery/jugular vein) at 16 weeks. In a separate study, HF-fed WT and α2-KD mice performed 5 weeks of exercise training (from 15 to 20 weeks of age) to test whether AMPKα2 is necessary to restore work tolerance. HF-fed WT mice had reduced exercise tolerance during an exercise stress test, and an attenuation in muscle glucose uptake and AMPKα2 activity during a single bout of exercise (P<0.05 versus chow). In chow-fed α2-KD mice, running speed and time were impaired ∼45 and ∼55%, respectively (P<0.05 versus WT chow); HF feeding further reduced running time ∼25% (P<0.05 versus α2-KD chow). In response to 5 weeks of exercise training, HF-fed WT and α2-KD mice increased maximum running speed ∼35% (P<0.05 versus pre-training) and maintained body weight at pre-training levels, whereas body weight increased in untrained HF WT and α2-KD mice. Exercise training restored running speed to levels seen in healthy, chow-fed mice. HF feeding impairs AMPKα2 activity in skeletal muscle during exercise in vivo. Although this defect directly contributes to reduced exercise capacity, findings in HF-fed α2-KD mice show that AMPKα2-independent mechanisms are also involved. Importantly, α2-KD mice on a HF-fed diet adapt to regular exercise by increasing exercise tolerance, demonstrating that this adaptation is independent of

Collection, Processing and Accuracy of Mobile Terrestrial Lidar Survey Data in the Coastal Environment

DTIC Science & Technology

2017-04-01

ER D C/ CH L TR -1 7- 5 Coastal Field Data Collection Program Collection, Processing, and Accuracy of Mobile Terrestrial Lidar Survey ... Survey Data in the Coastal Environment Nicholas J. Spore and Katherine L. Brodie Field Research Facility U.S. Army Engineer Research and Development...value to a mobile lidar survey may misrepresent some of the spatially variable error throughout the survey , and further work should incorporate full

Collection, Processing, and Accuracy of Mobile Terrestrial Lidar Survey Data in the Coastal Environment

DTIC Science & Technology

2017-04-01

ER D C/ CH L TR -1 7- 5 Coastal Field Data Collection Program Collection, Processing, and Accuracy of Mobile Terrestrial Lidar Survey ... Survey Data in the Coastal Environment Nicholas J. Spore and Katherine L. Brodie Field Research Facility U.S. Army Engineer Research and Development...value to a mobile lidar survey may misrepresent some of the spatially variable error throughout the survey , and further work should incorporate full

Unauthorized Disclosure: Can Behavioral Indicators Help Predict Who Will Commit Unauthorized Disclosure of Classified National Security Information?

DTIC Science & Technology

2015-06-01

Katherine Herbig, Espionage by the Numbers: A Statistical Overview, accessed April 14, 2015, http://www.wright.edu/rsp/Security/Treason/Numbers.htm 5...submitted for top-secret clearances with “derogatory financial information.”43 The debt amount reviewed was $500 in delinquency for at least 120 days, which...Investigative Service’s (DIS) “ delinquent debt criteria with amount of delinquent debt” and Defense Central Index of Investigation’s (DCII) final

Governing Geoengineering Research: A Political and Technical Vulnerability Analysis of Potential Near-Term Options

DTIC Science & Technology

2011-01-01

weather events, or the spread of tropical diseases into North America. The net A Vulnerability-and-Response-Option Analysis Framework for a Risk...Avoidable Surprises, Cambridge: Cambridge University Press, 2002. Doney, Scott C., Victoria J. Fabry , Richard A. Feely, and Joan A. Kleypas, “Ocean...Falkenmark, Louise Karlberg, Robert W. Corell, Victoria J. Fabry , James Hansen, Brian Walker, Diana Liverman, Katherine Richardson, Paul Crutzen, and

Lithium-Ion Battery Failure: Effects of State of Charge and Packing Configuration

DTIC Science & Technology

2016-08-22

Naval Research Laboratory Washington, DC 20375-5320 NRL/MR/6180--16-9689 Lithium - Ion Battery Failure: Effects of State of Charge and Packing...PAGES 17. LIMITATION OF ABSTRACT Lithium - Ion Battery Failure: Effects of State of Charge and Packing Configuration Neil S. Spinner,* Katherine M. Hinnant...Steven G. Tuttle (202) 404-3419 Lithium - ion battery safety remains a significant concern, as battery failure leads to ejection of hazardous materials

Documents Related to Churchill and FDR. The Constitution Community: The Great Depression and World War II (1929-1945).

ERIC Educational Resources Information Center

Gray, Tom

During World War II, a close friendship and excellent working relations developed between President Franklin D. Roosevelt (FDR) and Prime Minister Winston Churchill that were crucial in the establishment of a unified effort to deal with the Axis powers. In early 1941, FDR began the long-term correspondence that developed into a close working…

First Gentleman of the World: The Eulogistic Rhetoric of Adlai Ewing Stevenson.

ERIC Educational Resources Information Center

Gardner, Greg H.

A study examined three eulogies offered by Adlai Stevenson upon the deaths of important public figures (Eleanor Roosevelt, John F. Kennedy, and Sir Winston Churchill), in order to determine how each address fulfilled the purposes of this unique rhetorical genre. Each eulogy was examined with the purposes of eulogistic speaking in mind: (1) to…

Rawls, Race, and Education: A Challenge to the Ideal/Nonideal Divide

ERIC Educational Resources Information Center

Thompson, Winston C.

2015-01-01

In this essay, Winston C. Thompson questions the rigidity of the boundary between ideal and nonideal theory, suggesting a porosity that allows elements of both to be brought to bear upon educational issues in singularly incisive ways. In the service of this goal, Thompson challenges and extends John Rawls's theory of justice as fairness, bringing…

U.S. Foreign Policy and the UN System. Special Bibliography Series.

DTIC Science & Technology

1995-10-01

34Operation Provide Comfort: A Case Study in Humanitarian Relief and Foreign Assistance" Air Force Law Review 37 (1994): 225-38. 21 Mendez , Ruben 1... Carole Forced Out: The Agony of the Refuzee in Our Time. New York Random, 1989 (IIV 640 .K57 1989) 3( Langley, Winston E., ed. Human Rights: Sixtv Maior

A preliminary report on the geology of the volcanic-rock-hosted Barite Hill gold deposit, Carolina slate belt

USGS Publications Warehouse

Clark, Sandra H.; Greig, David D.; Bryan, Norman L.

1992-01-01

Text and copies of slides for a paper presented at the meeting of the Southeastern Section of the Geological Society of America in Winston-Salem, North Carolina, March 19, 1992. The Barite Hill mine is located in the southern part of the Carolina slate belt of South Carolina just north of the Georgia border.

The Latham Way: Implications

ERIC Educational Resources Information Center

Bell, Edwin D.; Powell, Frankie Denise; Johnson-Green, Gwendolyn

2011-01-01

This paper is a case study of the impact of a community-based, collaborative, mentoring intervention on the academic and personal success of a group of 32 students who were enrolled in Rowland Hill Latham Elementary School in the Winston-Salem/Forsyth County Schools during the year that the North Carolina Department of Public Instruction…

Developing Models to Forcast Sales of Natural Christmas Trees

Treesearch

Lawrence D. Garrett; Thomas H. Pendleton

1977-01-01

A study of practices for marketing Christmas trees in Winston-Salem, North Carolina, and Denver, Colorado, revealed that such factors as retail lot competition, tree price, consumer traffic, and consumer income were very important in determining a particular retailer's sales. Analyses of 4 years of market data were used in developing regression models for...

A Comparative Study of African-American Males vs Females at a Minority Institute of Higher Learning and the Role of Supplemental Instruction

ERIC Educational Resources Information Center

Rafi, Fawad; Karagiannis, Nikolaos

2013-01-01

The purpose of this paper is to draw a comparison of high attrition rates among African-American males versus African-American females in higher education and examine the role of Supplemental Instruction (SI). The study was conducted at a minority institution (Winston-Salem State University) where African-American students are in the majority. For…

Behind Textbook Censorship.

ERIC Educational Resources Information Center

Parker, Franklin; Parker, Betty

Textbook censorship cases from Tennessee and Alabama have been brought before the U.S. Supreme Court. In east Tennessee, fundamentalist families objected to a 1983 Holt, Rinehart, and Winston reading series for grades 1-8. Federal District Judge Thomas G. Hull held that Hawkins County Schools had violated the families' First Amendment rights and…

11. HISTORICAL VIEW OF CHURCH WITH ENCLOSED STAIRWAY ADDITION, LOOKING ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

11. HISTORICAL VIEW OF CHURCH WITH ENCLOSED STAIRWAY ADDITION, LOOKING NORTHWEST, 1850s. Photocopied from Henry Pleasants's book, History of Old St. David's Church, published in 1915 by John C. Winston Co. It is perhaps the earliest photograph of the church. - St. David's Church (Episcopal), Valley Forge Road (Newtown Township), Wayne, Delaware County, PA

The Grief Account: Dimensions of a Contemporary Bereavement Genre

ERIC Educational Resources Information Center

Dennis, Michael Robert

2008-01-01

The genre of the grief account is identified to include published narratives of surviving grief. Thematic analysis of Andrew Holleran's (2006) "Grief: A Novel," Lolly Winston's (2004) "Good Grief: A Novel," Joan Didion's (2005) "The Year of Magical Thinking," and J. Canfield and M. V. Hansen's (2003) "Chicken Soup for the Grieving Soul: Stories…

Experimental evidence that bioenergetics disruption is not mainly involved in the brain injury of glutaryl-CoA dehydrogenase deficient mice submitted to lysine overload.

PubMed

Amaral, Alexandre Umpierrez; Cecatto, Cristiane; Seminotti, Bianca; Ribeiro, César Augusto; Lagranha, Valeska Lizzi; Pereira, Carolina Coffi; de Oliveira, Francine Hehn; de Souza, Diogo Gomes; Goodman, Stephen; Woontner, Michael; Wajner, Moacir

2015-09-16

Bioenergetics dysfunction has been postulated as an important pathomechanism of brain damage in glutaric aciduria type I, but this is still under debate. We investigated activities of citric acid cycle (CAC) enzymes, lactate release, respiration and membrane potential (ΔΨm) in mitochondrial preparations from cerebral cortex and striatum of 30-day-old glutaryl-CoA dehydrogenase deficient (Gcdh-/-) and wild type mice fed a baseline or a high lysine (Lys, 4.7%) chow for 60 or 96h. Brain histological analyses were performed in these animals, as well as in 90-day-old animals fed a baseline or a high Lys chow during 30 days starting at 60-day-old. A moderate reduction of citrate synthase and isocitrate dehydrogenase activities was observed only in the striatum from 30-day-old Gcdh-/- animals submitted to a high Lys chow. In contrast, the other CAC enzyme activities, lactate release, the respiratory parameters state 3, state 4, the respiratory control ratio and CCCP-stimulated (uncoupled) state, as well as ΔΨm were not altered in the striatum. Similarly, none of the evaluated parameters were changed in the cerebral cortex from these animals under baseline or Lys overload. On the other hand, histological analyses revealed the presence of intense vacuolation in the cerebral cortex of 60 and 90-day-old Gcdh-/- mice fed a baseline chow and in the striatum of 90-day-old Gcdh-/- mice submitted to Lys overload for 30 days. Taken together, the present data demonstrate mild impairment of bioenergetics homeostasis and marked histological alterations in striatum from Gcdh-/- mice under a high Lys chow, suggesting that disruption of energy metabolism is not mainly involved in the brain injury of these animals. Copyright © 2015 Elsevier B.V. All rights reserved.

A high-fat high-sugar diet-induced impairment in place-recognition memory is reversible and training-dependent.

PubMed

Tran, Dominic M D; Westbrook, R Frederick

2017-03-01

A high-fat high-sugar (HFHS) diet is associated with cognitive deficits in people and produces spatial learning and memory deficits in rodents. Notable, such diets rapidly impair place-, but not object-recognition memory in rats within one week of exposure. Three experiments examined whether this impairment was reversed by removal of the diet, or prevented by pre-diet training. Experiment 1 showed that rats switched from HFHS to chow recovered from the place-recognition impairment that they displayed while on HFHS. Experiment 2 showed that control rats ("Untrained") who were exposed to an empty testing arena while on chow, were impaired in place-recognition when switched to HFHS and tested for the first time. However, rats tested ("Trained") on the place and object task while on chow, were protected from the diet-induce deficit and maintained good place-recognition when switched to HFHS. Experiment 3 examined the conditions of this protection effect by training rats in a square arena while on chow, and testing them in a rectangular arena while on HFHS. We have previously demonstrated that chow rats, but not HFHS rats, show geometry-based reorientation on a rectangular arena place-recognition task (Tran & Westbrook, 2015). Experiment 3 assessed whether rats switched to the HFHS diet after training on the place and object tasks in a square area, would show geometry-based reorientation in a rectangular arena. The protective benefit of training was replicated in the square arena, but both Untrained and Trained HFHS failed to show geometry-based reorientation in the rectangular arena. These findings are discussed in relation to the specificity of the training effect, the role of the hippocampus in diet-induced deficits, and their implications for dietary effects on cognition in people. Copyright © 2016 Elsevier Ltd. All rights reserved.

Inhibition of Opioid Transmission at the μ-Opioid Receptor Prevents Both Food Seeking and Binge-Like Eating

PubMed Central

Giuliano, Chiara; Robbins, Trevor W; Nathan, Pradeep J; Bullmore, Edward T; Everitt, Barry J

2012-01-01

Endogenous opioids, and in particular μ-opioid receptors, have been linked to hedonic and rewarding mechanisms engaged during palatable food intake. The aim of this study was to investigate the effects of GSK1521498, a novel μ-opioid receptor antagonist, on food-seeking behavior and on binge-like eating of a highly preferred chocolate diet. Food seeking was measured in rats trained to respond for chocolate under a second-order schedule of reinforcement, in which prolonged periods of food-seeking behavior were maintained by contingent presentation of a reward-associated conditioned reinforcer. After reaching a stable baseline in both procedures, animals were treated with GSK1521498 (0.1, 1, and 3 mg/kg; IP) or naltrexone (NTX, 0.1, 1, and 3 mg/kg; SC). The binge eating model was characterized by four temporally contiguous phases: 1-h chow access, 2-h food deprivation, 10-min chow access, and 10-min access to either chocolate-flavoured food or standard chow. During training the rats developed binge-like hyperphagia of palatable food and anticipatory chow hypophagia (anticipatory negative contrast). Both compounds reduced binge-like palatable food hyperphagia. However, GSK1521498 reduced the impact of high hedonic value on ingestion more specifically than NTX, abolishing anticipatory chow hypophagia. GSK1521498 also dose-dependently reduced food seeking both before and after food ingestion, whereas NTX reduced food seeking only after food ingestion. Thus, while both drugs affected the hedonic value of the preferred food, GSK1521498 also directly decreased incentive motivation for chocolate. Selective μ-opioid receptor antagonism by GSK1521498 may have utility as a treatment for reducing maladaptive, palatability-driven eating behavior by reducing the motivational properties of stimuli that elicit the binge eating commonly associated with obesity. PMID:22805601

Differences in bingeing behavior and cocaine reward following intermittent access to sucrose, glucose or fructose solutions

PubMed Central

Rorabaugh, Jacki M.; Stratford, Jennifer M.; Zahniser, Nancy R.

2015-01-01

Daily intermittent access to sugar solutions results in intense bouts of sugar intake (i.e. bingeing) in rats. Bingeing on sucrose, a disaccharide of glucose and fructose, has been associated with a “primed” mesolimbic dopamine (DA) pathway. Recent studies suggest glucose and fructose engage brain reward and energy sensing mechanisms in opposing ways and may drive sucrose intake through unique neuronal circuits. Here, we examined in male Sprague-Dawley rats whether or not (1) intermittent access to isocaloric solutions of sucrose, glucose or fructose results in distinctive sugar bingeing profiles and (2) previous sugar bingeing alters cocaine locomotor activation and/or reward, as determined by conditioned place preference (CPP). To encourage bingeing, rats were given 24-h access to water and 12 h-intermittent access to chow plus an intermittent bottle that contained water (control) or 8% solutions of sucrose, glucose or fructose for 9 days, followed by ad libitum chow diet and a 10 day cocaine (15 mg/kg; i.p.) CPP paradigm. By day 4 of the sugar bingeing diet, sugar bingeing in the fructose group surpassed the glucose group, with the sucrose group being intermediate. All three sugar groups had similar chow and water intake throughout the diet. In contrast, controls exhibited chow bingeing by day 5 without altering water intake. Similar magnitudes of cocaine CPP were observed in rats with a history of sucrose, fructose or chow (control) bingeing. Notably, the glucosebingeing rats did not demonstrate a significant cocaine CPP despite showing similar cocaine-induced locomotor activity as the other diet groups. Overall, these results show that fructose and glucose, the monosaccharide components of sucrose, produce divergent degrees of bingeing and cocaine reward. PMID:26079112

Dietary obesity caused by a specific circadian eating pattern.

PubMed

Hariri, Niloofar; Thibault, Louise

2011-04-01

The eating pattern is altered by high-fat diet-induced obesity. To clarify whether this is dependent on the fatty acid profile of the diet, the authors conducted two studies on adult female Sprague-Dawley rats fed normal-fat chow or high-fat diets with varying fatty acid composition. Eating pattern and body weight were assessed in rats fed canola-based (low in saturated fatty acids) or lard-based (moderate in saturated fatty acids) diets for 7 days, and in animals fed chow or canola- or butter-based diets (rich in saturated fatty acids) for 43 days. These parameters were also determined when restricted amounts of low-fat canola- or butter-based diets were consumed for 25 days. Early exposure to canola or lard high-fat feeding or prolonged access to canola- or butter-based fat-rich diets (relative to chow feeding) did not alter the normal light-dark distribution of food and energy intake. All animals ingested most of their food during the dark phase. However, feeding the high-fat canola- and butter-based diets produced an altered eating pattern during the light phase characterized by a smaller number of meals, longer intermeal interval, and enhanced satiety ratio, and consumption of shorter-lasting meals than chow-fed animals. Relative to canola or chow feeding, butter-fed animals consumed a lower number of meals during the dark phase and had a higher eating rate in the light phase, but ate larger meals overall. Only butter feeding led to overeating and obesity. When given a restricted amount of low-fat canola- or butter-based diet at the start of the light phase, rats ate most of their food in that phase and diurnal rather than nocturnal feeding occurred with restriction. These findings underscore the role of saturated fatty acids and the resulting eating pattern alteration in the development of obesity.

Developmental programming of lipid metabolism and aortic vascular function in C57BL/6 mice: a novel study suggesting an involvement of LDL-receptor.

PubMed

Chechi, Kanta; McGuire, John J; Cheema, Sukhinder K

2009-04-01

We have previously shown that a maternal high-fat diet, rich in saturated fatty acids (SFA), alters the lipid metabolism of their adult offspring. The present study was designed to investigate 1) whether alterations in hepatic LDL-receptor (LDL-r) expression may serve as a potential mechanism of developmental programming behind the altered lipid metabolism of the offspring, 2) whether altered lipid metabolism leads to aortic vascular dysfunction in the offspring, 3) whether deleterious effects of SFA exposure preweaning are influenced by postweaning diet, and 4) whether gender-specific programming effects are observed. Female C57Bl/6 mice were fed a high-SFA diet or regular chow during gestation and lactation while their pups, both male and female, received either SFA or a chow diet after weaning. Male offspring obtained from mothers fed an SFA diet and those who continued on chow postweaning had higher plasma triglycerides and total cholesterol, whereas female offspring had higher plasma total and LDL cholesterol levels, lower hepatic LDL-r mRNA expression, and reduced aortic contractile responses compared with the offspring that were fed chow throughout the study. A comparison of the postweaning diet revealed significantly lower hepatic LDL-r expression along with significantly higher plasma LDL-cholesterol concentration in the female offspring that were obtained from mothers fed an SFA diet and who continued on an SFA diet postweaning, compared with the female offspring that were obtained from mothers fed an SFA diet but who continued on chow postweaning. In conclusion, we report a novel observation of hepatic LDL-r-mediated programming of altered lipid metabolism, along with aortic vascular dysfunction, in the female offspring of mothers fed a high-SFA diet. Male offspring only exhibited dyslipidemia, suggesting gender-mediated programming. This study further highlighted the role of postweaning diets in overriding the effects of maternal programming.

Blues for Elle - Microbial Bebop

DOE Office of Scientific and Technical Information (OSTI.GOV)

Larsen, Peter

This musical composition was created from data of microbes - bacteria, algae and other microorganisms - sampled in the English Channel. (Above, the USS Winston S. Churchill traverses the English Channel.) Argonne National Laboratory biologist Peter Larsen created the songs as a unique way to present and comprehend large datasets. Some marine microbial taxa are most often present in the L4 Station community at very low abundance, but occasionally become highly dominant community members. To link these microbial blooms to relevant physical parameters, the chords in this composition are derived from changes in chlorophyll A concentrations and salinity. The melodymore » for each measure is derived from the relative abundances of typically rare taxa that were observed to occasionally bloom to higher abundance in the following order: Cyanobacteria, Vibrionales, Opitulates, Pseudomondales, Rhizobiales, Bacillales, Oceanospirallales, and Sphingomonadales. More information at http://www.anl.gov/articles/songs-key... Photo: USS Winston S. Churchill and Royal Navy HMS Cumberland transit the English Channel, courtesy U.S. Navy (http://www.flickr.com/photos/usnavy/5...)« less

The effect of sulforaphane on oxidative stress and inflammation in rats with toxic hepatitis induced by acetaminophene.

PubMed

Dokumacioglu, E; Iskender, H; Aktas, M S; Hanedan, B; Dokumacioglu, A; Sen, T M; Musmul, A

2017-01-01

The aim of the present study was to reveal the possible effect of sulforaphane on oxidative stress and inflammation in rats liver with toxic hepatitis induced by acetaminophene. Sulforaphane is a compound with high antioxidant properties. Acetaminophen, which is a para-aminophenol derivative, can lead to fatal hepatic necrosis with direct hepatotoxic effects at high doses. Thirty six male Sprague-Dawley rats were randomly divided into four groups. Control group (n = 9) was fed with standard rat chow and water for 3 days. Group APAP (n = 9) received a single dose acetaminophen 1 g/kg by oral gavage in addition to standard chow and water. Group SFN (n = 9) received sulforaphane 500 μg/kg by oral gavage in addition to standard chow and water for 3 days. Group APAP+SFN (n = 9) received sulforaphane 500 μg/kg and a single dose acetaminophen 1 g/kg by oral gavage in addition to standard chow and water. Acetaminophen was administered three hours after SFN administration. Neopterin, MDA, AST, ALT and CRP levels of group APAP were significantly increased compared to control group. GSH level of group APAP was significantly lower than in the control group. Sulforaphane is a protective agent against acetaminophen-induced liver damage and it can be added in the treatment protocol (Tab. 1, Fig. 5, Ref. 51).

Estrous cycle and food availability affect feeding induced by amygdala 5-HT receptor blockade.

PubMed

Parker, Graham C; Bishop, Christopher; Coscina, Donald V

2002-04-01

We have recently reported that bilateral infusions of the 5-HT receptor antagonist metergoline (MET) into the posterior basolateral amygdala (pBLA) elicit feeding in female rats tested at mid-light cycle. The present study was performed to determine whether (1) testing at two different phases of the estrous cycle, and/or (2) the palatability of the food might modify this effect. Subjects were 18 adult females with bilateral pBLA cannulae. Following familiarization with Froot Loops cereal, a within-subjects design tested all animals for 1- and 2-h food intake under 2 Drug (0.3 nmol MET vs. Vehicle), 2 Estrous Cycle (diestrus vs. estrus) and 2 Food (lab chow vs. Froot Loops) conditions. Rats weighed more at diestrus than at proestrus (P<.05) or estrus (P<.005). Multivariate analyses of variance (MANOVAs) revealed a preference for Froot Loops over lab chow (P<.0001). MET increased feeding regardless of food type (P<.0001). Rats ate more Froot Loops (P<.01), but not lab chow, at diestrus vs. estrus. A three-way interaction (P<.05) showed rats ate more during the first hour in estrus than in diestrus to lab chow but not Froot Loops. These data suggest pBLA MET differentially affects feeding over the estrous cycle depending on the palatability of food available.

Insulin resistance impairs nigrostriatal dopamine function.

PubMed

Morris, J K; Bomhoff, G L; Gorres, B K; Davis, V A; Kim, J; Lee, P-P; Brooks, W M; Gerhardt, G A; Geiger, P C; Stanford, J A

2011-09-01

Clinical studies have indicated a link between Parkinson's disease (PD) and Type 2 Diabetes. Although preclinical studies have examined the effect of high-fat feeding on dopamine function in brain reward pathways, the effect of diet on neurotransmission in the nigrostriatal pathway, which is affected in PD and parkinsonism, is less clear. We hypothesized that a high-fat diet, which models early-stage Type 2 Diabetes, would disrupt nigrostriatal dopamine function in young adult Fischer 344 rats. Rats were fed a high fat diet (60% calories from fat) or a normal chow diet for 12 weeks. High fat-fed animals were insulin resistant compared to chow-fed controls. Potassium-evoked dopamine release and dopamine clearance were measured in the striatum using in vivo electrochemistry. Dopamine release was attenuated and dopamine clearance was diminished in the high-fat diet group compared to chow-fed rats. Magnetic resonance imaging indicated increased iron deposition in the substantia nigra of the high fat group. This finding was supported by alterations in the expression of several proteins involved in iron metabolism in the substantia nigra in this group compared to chow-fed animals. The diet-induced systemic and basal ganglia-specific changes may play a role in the observed impairment of nigrostriatal dopamine function. Copyright © 2011 Elsevier Inc. All rights reserved.

Peripheral nerve metabolism and zinc levels in streptozotocin induced diabetic rats. Effect of diets high in fish and corn oil

DOE Office of Scientific and Technical Information (OSTI.GOV)

Burke, J.P.; Fenton, M.R.

1991-03-15

This study was designed to assess the effects of diets high in fish and corn oil on peripheral nerve metabolism in streptozotocin (STZ) induced diabetic rats. A type I diabetic state was induced in female Sprague-Dawley rats by injection of STZ. Animals were divided into three dietary groups; normal rat chow, high corn oil diet and high fish oil diet. After 4 weeks animals were analyzed for nerve conduction velocity, bled and then sacrificed. Sciatic nerves were removed, processed and several biochemical parameters determined. Plasma zinc levels were elevated in the STZ normal chow group compared to non-diabetic controls. Bothmore » corn oil and fish oil diets tended to eliminate the rise in plasma zinc. Differences in subcellular distribution of zinc in sciatic nerves were also observed. Normal chow STZ animals displayed a 20% decrease in nerve conduction velocity compared to control. Dietary supplementation with either fish or corn oil seemed to ameliorate these effects. Biochemical analysis of Na{sup +}-K{sup +}-ATPase and protein kinase C revealed a decrease in activity in normal chow animals compared to control groups. Again, dietary intervention with either fish or corn oil seemed to return these activities back to normal. The results suggest a link between zinc metabolism and peripheral nerve metabolism which can be modified by dietary intervention.« less

Chow Down! Using Madagascar Hissing Cockroaches to Explore Basic Nutrition Concepts

ERIC Educational Resources Information Center

Wagler, Ron

2009-01-01

The Madagascar hissing cockroach ("Gromphadorhina portentosa") is one of the most exciting and enjoyable animals to incorporate into your science curriculum. Madagascar hissing cockroaches (MHCs) do not bite, are easy to handle, produce little odor compared to many terrarium animals, have a fascinating social structure, are easy to breed, teach…

Rhetoric Reconsidered--Here and Abroad (Global Issues).

ERIC Educational Resources Information Center

Naff, Bea; Schnaufer, Thiela

1997-01-01

Describes a project in a third-year Latin class in a high school in the Appalachian foothills in which students (1) identified and analyzed classical rhetorical devices in speeches by Winston Churchill and Martin Luther King Jr.; (2) used rhetorical frames; and (3) wrote their own speeches as part of a year-long writing exchange with senior-level…

Metacognitive Theory Applied: Strategic Reading Instruction in the Current Generation of Basal Readers.

ERIC Educational Resources Information Center

Schmitt, Maribeth Cassidy; Hopkins, Carol J.

A study examined the content of eight 1989 editions of the major basal reading series--those of Harcourt Brace Jovanovich; D.C. Heath and Co.; Holt Rinehart and Winston; Houghton Mifflin; Macmillan; McGraw-Hill; Scott, Foresman and Co.; and Silver Burdett and Ginn. The study determined how and the extent to which lessons and activities that…

Change Detection in Rough Time Series

DTIC Science & Technology

2014-09-01

Business Statistics : An Inferential Approach, Dellen: San Francisco. [18] Winston, W. (1997) Operations Research Applications and Algorithms, Duxbury...distribution that can present significant challenges to conventional statistical tracking techniques. To address this problem the proposed method...applies hybrid fuzzy statistical techniques to series granules instead of to individual measures. Three examples demonstrated the robust nature of the

Factors that influence Christmas tree sales

Treesearch

Thomas H. Pendleton; Lawrence D. Garrett

1970-01-01

An analysis of the metropolitan Christmas tree market in Winston-Salem, N. C., shows that to sell more trees, Christmas tree retailers should locate their lots on heavily traveled streets in business areas, have adequate parking facilities, advertise, and have attractive displays of trees. Retailers who follow these practices can expect to receive higher prices for...

The Nature of the Electron

ERIC Educational Resources Information Center

Lincoln, Don

2016-01-01

Winston Churchill once said of Russia that it was a riddle wrapped in mystery inside an enigma. Were the British Bulldog a physicist, he might have been talking of something other than our Slavic comrades. He might have been talking about an electron. This article covers the more modern representations of the electron. A brief reminder of the…

Romans 12 Motivational Gifts and College Professors: Implications for Job Satisfaction and Person-Job Fit

ERIC Educational Resources Information Center

Tomlinson, Jon C.; Winston, Bruce E.

2011-01-01

This study builds on earlier work by DellaVecchio and Winston (2004) and McPherson (2008). They addressed the seven motivational gifts Paul wrote about in Romans 12:3-8 as a means for addressing job satisfaction and person-job fit among college professors. Using a snowball sampling method, 89 college professors completed the online survey…

Chopper GEN2 + Glyphosate efficacy for height classes of hardwood sprouts recolonizing six clearcut pine sites

Treesearch

Jimmie Yeiser; Andrew Ezell

2015-01-01

The purpose of this study was to assess sprout size as a determinant of subsequent control by a standard, single rate of imazapyr +glyphosate applied during site preparation. All study sites were in the hilly upper coastal plain of Mississippi (Winston or Oktibbeha Counties) or Louisiana (Sabine or Winn Parishes) and supported loblolly pine (Pinus taeda L.) plantations...

STS-87 Day 15 Highlights

NASA Technical Reports Server (NTRS)

1997-01-01

On this fifteenth day of the STS-87 mission, the flight crew, Cmdr. Kevin R. Kregel, Pilot Steven W. Lindsey, Mission Specialists Winston E. Scott, Kalpana Chawla, and Takao Doi, and Payload Specialist Leonid K. Kadenyuk spend a good part of their day checking out the important space craft systems that are needed to support reentry.

Analysis of Market Factors Associatedwith Sales of Cut Natural Christmas Trees

Treesearch

Lawrence D. Garrett

1977-01-01

A study of the market performance of natural Christmas tree retailers in Winston-Salem, North Carolins, revealed that success was strongly related to location in active retail shopping areas. Christmas tree retailers in shopping centers or areas high in retail sales sold more trees, received a higher average price, and had fewer trees left unsold than retailers in...

Vacuum Ultraviolet Laser Probe of Chemical Dynamics of Aerospace Relevance

DTIC Science & Technology

2012-09-12

carbide cation”, J. Phys. Chem. A (invited), 113, 4242 (2009). 5. Kai-Chung Lau , Yih-Chung Chang, Chow-Sheng Lam , and C. Y. Ng, “High-level ab...Chem. A (invited), 113, 14321 (2009). 6. Kai-Chung Lau , Yih-Chung Chang, Chow-Sheng Lam , and C. Y. Ng, “High-level ab initio predictions of the...VI. Selected scientific findings 1. Kai-Chung Lau , Yih-Chung Chang, Xiaoyu Shi, and C. Y. Ng, “High-level ab initio predictions of the ionization

Evaluation of Chemotherapeutic Agents Against Malaria, Drugs, Diet, and Biological Response Modifiers.

DTIC Science & Technology

1991-10-29

The oils, MCT and Miglyol , were found to be suitable placebos for fish oil. A normal chow diet (with adequate vitamin E levels) supplemented with 20...year. Co-enzyme Q10 did not act as an antioxidant like vitamin E during a malarial infection. Two oils, MCT and Miglyol , were found to be suitable...manipulation. In experiment 84 miglyol was added to a standard rodent chow diet with normal levels of vitamin E to see whether it whould interfere with the

A pilot study on the effect of Catha edulis Frosk., (Celastraceae) on metabolic syndrome in WOKW rats.

PubMed

Mahmood, Samira Abdulla; Lindequist, Ulrike

2008-04-10

This study investigated the effect of Catha edulis (khat) on some important parameters of the metabolic syndrome in Wistar Ottawa Karlsburg W (WOKW) rat. The animals were fed with the standard chow containing 5% air dried pulverized khat leaves for 14 days; followed by the standard chow for 16 days. The khat leaves were sorted into green (khat light; KL) and crimson (khat dark; KD) leaves. The control rats were fed on standard chow. Blood glucose (G), serum insulin, serum leptin and serum lipids (triglycerides, total cholesterol, HDL-, LDL-, and VLDL cholesterol) were determined. Feeding with khat leaves reduced the body weight and the triglyceride level of the animals. The effect of KD on these parameters was stronger than that of KL. KD lowered the blood glucose concentration and the leptin content whereas KL was inactive. The khat intake had no significant influence on serum insulin, total serum cholesterol, HDL-, LDL- and VLDL-cholesterol.

Cryomicrotome Applications: Techniques for the Study of Skeletal Materials.

DTIC Science & Technology

1983-09-01

Dehydrate rapidly and mount Results: collagen-blue ground substance of cartilage and bones-shades of blue mucus, amyloid, other hyaline substances-shades...AD-N±3? SiB CRYOMICROTOME AiPPLICATIONS: TECHNIQUES FOR THE STUDY OF i/i SKELETAL MATERIAL.-[I AIR FORCE AEROSPACE MEDICAL RESEARCH LAB WRIGHT...THE STUDY OF SKELETAL MATERIALS .% . , KATHERINE C. SMITH CLARENCE U. OLOFF LEON E. KAZARIAN A.7t SEPTEMBER 1083 4-Z LUJ Approved for public release

Vietnam Head Injury Study - Phase III: A 30-Year Post-Injury Follow-Up Study

DTIC Science & Technology

2007-08-01

Michael Koenigs1, Edward D. Huey1, Vanessa Raymont1,2, Bobby Cheon2, Jeffrey Solomon3, Eric M. Wassermann1, & Jordan Grafman1 1Cognitive Neuroscience...Currently, Dr. Vanessa Raymont and colleagues are about to submit a manuscript to the journal Brain entitled, “Demographic, Structural and Genetic...PENETRATING HEAD INJURY Vanessa Raymont1&2, Amanda Greathouse1&2, Katherine Reding1&2, Robert Lipsky3, Andres Salazar2, and Jordan Grafman2* 1

Protecting Critical Rail Infrastructure

DTIC Science & Technology

2006-12-01

Gulliver.Trb.Org/Publications/Sr/Sr270.Pdf. 38. Allan J. DeBlasio, Terrance J. Regan, Margaret E . Zirker, Katherine S. Fichter, Kristin Lovejoy ...getrpt?GAO-04-598T. 4. Ibid. 5. Thomas H. Kean, Lee H. Hamilton, Richard Ben-Veniste, Fred F. Fielding, Jamie S. Gorelick, Slade Gorton, Bob Kerrey...Committee, Current and Projected National Security Threats to the United States, Vice Admiral Lowell E . Jacoby, United States Navy, Director, Defense

Bouncing Back From War Trauma: Resiliency in Global War on Terror’s Wounded Warriors

DTIC Science & Technology

2015-02-11

Casualties of the Global War on Terror and Their Future Impact on Health Care and Society: A Looming Public Health Crisis .” Military Medicine 179 (April...Casualties of the Global War on Terror and Their Future Impact on Health Care and Society: A Looming Public Health Crisis .” Military Medicine 179...AIR WAR COLLEGE AIR UNIVERSITY BOUNCING BACK FROM WAR TRAUMA: RESILIENCY IN GLOBAL WAR ON TERROR’S WOUNDED WARRIORS by Katherine H

A Comparison of Nurses’ Activities Under Two Models of Administration

DTIC Science & Technology

1985-08-01

Angela Sheehan, "Innovation in Cancer Nursing and the Role of the Nurse in Clinical Trials," Progress in Clinical and Biological Research 121 (1983): 87...by Diagnosis-Related Groups,* Annals of Internal Medicine 100 (April 1984): 576. 12Tony DeCrosta, " Megatrends in Nursing: 10 New Directions that are...in Clinical Trials." Progress in Clinical and Biological Research 121 (1983): 87-92. Beyers, Marjorie: Byre, Calvin: Levy, Paul: Mallin, Katherine

Navy CG(X) Cruiser Program: Background, Oversight Issues, and Options for Congress

DTIC Science & Technology

2008-10-27

ELEMENT NUMBER 6. AUTHOR(S) 5d. PROJECT NUMBER 5e . TASK NUMBER 5f. WORK UNIT NUMBER 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) Congressional...report (Katherine McIntire Peters, “Navy’s Top Officer Sees Lessons in Shipbuilding Program Failures,” GovernmentExecutive.com, September 24, 2008) quoted...40 A related question is whether the schedule for procuring CG(X)s is properly aligned with foreign-country ballistic missile development programs. A

Navy CG(X) Cruiser Program: Background for Congress

DTIC Science & Technology

2010-04-08

PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d. PROJECT NUMBER 5e . TASK NUMBER 5f. WORK UNIT NUMBER 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES...Inside the Navy, October 27, 2008. Another press report (Katherine McIntire Peters, “Navy’s Top Officer Sees Lessons in Shipbuilding Program Failures...have changed.37 A related question was whether the schedule for procuring CG(X)s was properly aligned with foreign-country ballistic missile

Navy CG(X) Cruiser Program: Background, Oversight Issues, and Options for Congress

DTIC Science & Technology

2009-09-18

and Options for Congress 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d. PROJECT NUMBER 5e . TASK NUMBER 5f...October 27, 2008. Another press report (Katherine McIntire Peters, “Navy’s Top Officer Sees Lessons in Shipbuilding Program Failures... aligned with foreign-country ballistic missile development programs. A 2005 defense trade press report, for example, states that “navy officials

A Relative-Motion Microworld.

DTIC Science & Technology

1985-09-01

from the Department of Physics, for their guidance; to fellow graduate students Dennis Lee and Jim Miller for providing motivation and support; and to... motivation and most importantly, love. Thanks to my parents, Bill and 4 . °.. - - .... L7 4--, Margaret Greenwood, for numerous trips to Boston to help...out: to mly sister, Jennifer Ristok, for her quiet motivation and friendship; to my daughters. Katherine and Jennifer, for providing a link with

The Agility Advantage: A Survival Guide for Complex Enterprises and Endeavors

DTIC Science & Technology

2011-09-01

weighted probability 75th pctl weighted probability 13. Carman. K. G. and Kooreman, P, “ Flu Shots, Mammogram, and the Perception of Probabilities,” 2010...sharing capabilities until users can tes- tify to the benefi ts. This creates a chicken and egg situa- tion, because the consumers of information fi...Bibliography 563 Campen, Alan D. Look Closely at Network-Centric Warfare. Signal, January 2004. Carman, Katherine G., and Peter Kooreman, Peter. Flu Shots

Basal Ganglia Dopamine-gamma-Aminobutyric Acid-Acetylcholine Interaction in Organophosphate-Induced Neurotoxicity. Appendices

DTIC Science & Technology

1982-12-01

Animals were maintained ad llbltua on standard laboratory chow and tap water and were housed in a room with automatic 12 hour light and dark cycles and...supernatant fluid was centrl- fuged at 20,000 x g for 20 min to obtain a crude mitochondria ! pellet. The crude mitochondrlal pellet was resuspended...chow and tap water and wer- housed in a room with automatic 12 hour light and dark cycles and temperature set at 25.5 ± 1.8°C. DUsopropylfli’oro

The effect of adding fish oil to parenteral nutrition on hepatic mononuclear cell function and survival after intraportal bacterial challenge in mice.

PubMed

Moriya, Tomoyuki; Fukatsu, Kazuhiko; Maeshima, Yoshinori; Ikezawa, Fumie; Hashiguchi, Yojiro; Saitoh, Daizoh; Miyazaki, Masaru; Hase, Kazuo; Yamamoto, Junji

2012-05-01

Parenteral nutrition (PN) is indispensable for meeting caloric and substrate needs of patients who cannot receive adequate amounts of enteral nutrition; however, PN impairs hepatic immunity. We examined the effects of ω-3 and -6 polyunsaturated fatty acids, added individually to fat-free PN, on hepatic immunity in a murine model. We focused on serum liver enzymes, cytokine production, histopathology, and the outcomes after intraportal bacterial challenge. Male Institute of Cancer Research mice were randomized into 4 groups; ad libitum chow (CHOW), fat-free PN (FF-PN), PN + fish oil (FO-PN), or PN + safflower oil (SO-PN). After the mice had been fed for 5 days, hepatic mononuclear cells (MNCs) were isolated. The number of MNCs was counted and cytokine production (tumor necrosis factor [TNF]-α and interleukin [IL]-10) by hepatic MNCs in response to lipopolysaccharide (LPS) was measured. Blood samples were analyzed for hepatobiliary biochemical parameters. Moreover, 1.0 × 10(7) pseudomonas aeruginosa were delivered by intraportal injection. Survival and histology were examined. Hepatic MNC numbers were significantly less in the FO-PN and FF-PN than in the CHOW group, whereas the SO-PN group showed moderate recovery of hepatic MNC numbers. The CHOW, FO-PN, and SO-PN groups showed LPS dose-dependent increases in TNF-α levels. These increases were blunted in the FF-PN group. IL-10 levels were increased LPS dose-dependently in the CHOW and FO-PN groups, but no marked changes were observed with LPS stimulation in the SO-PN and FF-PN groups. Plasma levels of aspartate aminotransferase, alanine aminotransferase, and alkaline phosphatase were significantly greater in the FF-PN than in the FO- and SO-PN and CHOW groups. The FO-PN group showed significantly improved survival compared with the SO-PN and FF-PN groups, showing essentially no morphologic hepatic abnormalities. Addition of fish oil to PN was advantageous in terms of reversing PN-induced deterioration of hepatic

Southeast Clinical Oncology Research Consortium, Inc. (SCOR) | Division of Cancer Prevention

Cancer.gov

The SCCC-Upstate is a merger of two successful legacy CCOPs known as Southeast Cancer Control Consortium, Inc. (SCCC) and Upstate Carolina (hereafter the Consortium) comprised of 23 components and 63 sub-components, located in a five-state area of the Southeast US (GA, NC, SC, TN, and VA) with a nonclinical Administrative Office (AO) in Winston-Salem, NC. The Consortium

Addition of Sulfometuron Methyl to Fall Site Preparation Tank Mixes Improves Herbaceous Weed Control

Treesearch

A.W. Ezell

2002-01-01

A total of 12 herbicide treatments were applied to a recently harvested forest site in Winston County, MS. All treatments were representative of forest site preparation tank mixtures and were applied early September, 1999. Three ounces of Oust7 were included in two of the tank mixes, and 19 ounces of Oustar7 were included in two of the mixes. All treatments were...

Preparing for Large-Force Exercises with Distributed Simulation: A Panel Presentation

DTIC Science & Technology

2010-07-01

Preparing for Large Force Exercises with Distributed Simulation: A Panel Presentation Peter Crane, Winston Bennett, Michael France Air Force...used distributed simulation training to complement live-fly exercises to prepare for LFEs. In this panel presentation , the speakers will describe... presentations on how detailed analysis of training needs is necessary to structure simulator scenarios and how future training exercises could be made more

Solar-power mountain concept

NASA Technical Reports Server (NTRS)

Clarke, V. C., Jr.

1977-01-01

Solar collectors on mountainside collect thermal energy for mountaintop powerplant. Sloped arrangement reduces heat-transport problem of level ground-based collector field. Heated air rises without mechanical pumps and buoyancy force supplies pumping power without further cost. Precision tracking requirement of power towers eliminated by butted-together Winston-type concentrator troughs. Low-cost native rock is used for heat storage.

Defense Budgeting in a Constrained Economy: Reengineering the Budget Process to Meet the Challenge of a Modernizing Zimbabwe Defense Force

DTIC Science & Technology

1998-06-01

Public Policy Analysis and Management Vol. 5 (Connecticut: JAI Press Inc ., 1992) 20. 38 Thomas A Simcik, Reengineering the Navy Program Objective...Winston Inc .,1969. Olvey, Lee D. The Economics of National Security, Avery Publishing Group : 1984. Premchand, A., Government Budgeting And Expenditure... the current process is presented and analyzed against relevant theory on policy analysis , reengineering, and contemporary budgeting systems, in

STS-87 Day 02 Highlights

NASA Technical Reports Server (NTRS)

1997-01-01

On this second day of the STS-87 mission, the flight crew, Cmdr. Kevin R. Kregel, Pilot Steven W. Lindsey, Mission Specialists Winston E. Scott, Kalpana Chawla, and Takao Doi, and Payload Specialist Leonid K. Kadenyuk are seen conducting experiments involving the effect of weightlessness on materials and fluids. They also work with an experiment to study Earth's protective ozone layers.

The E-Book Phenomenon: A Disruptive Technology

ERIC Educational Resources Information Center

Wilson, T. D.

2014-01-01

Introduction: The e-book and its associated technology have emerged as a disruptive technology over the past ten years. The aim of this paper is to discuss some of the consequences of this development, based on the work of the e-books in Sweden research projects. Argument: To explain the impact of the e-book phenomenon we use Winston's theory of…

Endogenous biosynthesis of thromboxane and prostacyclin in 2 distinct murine models of atherosclerosis.

PubMed

Praticò, D; Cyrus, T; Li, H; FitzGerald, G A

2000-12-01

Thromboxane A(2) is a potent vasoconstrictor and platelet agonist; prostacyclin is a potent platelet inhibitor and vasodilator. Altered biosynthesis of these eicosanoids is a feature of human hypercholesterolemia and atherosclerosis. This study examined whether in 2 murine models of atherosclerosis their levels are increased and correlated with the evolution of the disease. Urinary 2,3-dinor thromboxane B(2) and 2,3-dinor-6-keto prostaglandin F(1 alpha), metabolites of thromboxane and prostacyclin, respectively, were assayed in apoliprotein E (apoE)-deficient mice on chow and low-density lipoprotein receptor (LDLR)-deficient mice on chow and a Western-type diet. Atherosclerosis lesion area was measured by en face method. Both eicosanoids increased in apoE-deficient mice on chow and in LDLR-deficient mice on a high-fat diet, but not in LDLR-deficient mice on chow by the end of the study. Aspirin suppressed ex vivo platelet aggregation, serum thromboxane B(2), and 2,3-dinor thromboxane B(2), and significantly reduced the excretion of 2,3-dinor-6-keto prostaglandin F(1 alpha) in these animals. This study demonstrates that thromboxane as well as prostacyclin biosynthesis is increased in 2 murine models of atherogenesis and is secondary to increased in vivo platelet activation. Assessment of their generation in these models may afford the basis for future studies on the functional role of these eicosanoids in the evolution and progression of atherosclerosis. (Blood. 2000;96:3823-3826)

Maternal Western diet increases adiposity even in male offspring of obesity-resistant rat dams: early endocrine risk markers.

PubMed

Frihauf, Jennifer B; Fekete, Éva M; Nagy, Tim R; Levin, Barry E; Zorrilla, Eric P

2016-12-01

Maternal overnutrition or associated complications putatively mediate the obesogenic effects of perinatal high-fat diet on developing offspring. Here, we tested the hypothesis that a Western diet developmental environment increases adiposity not only in male offspring from obesity-prone (DIO) mothers, but also in those from obesity-resistant (DR) dams, implicating a deleterious role for the Western diet per se. Selectively bred DIO and DR female rats were fed chow (17% kcal fat) or Western diet (32%) for 54 days before mating and, thereafter, through weaning. As intended, despite chow-like caloric intake, Western diet increased prepregnancy weight gain and circulating leptin levels in DIO, but not DR, dams. Yet, in both genotypes, maternal Western diet increased the weight and adiposity of preweanlings, as early as in DR offspring, and increased plasma leptin, insulin, and adiponectin of weanlings. Although body weight normalized with chow feeding during adolescence, young adult Western diet offspring subsequently showed decreased energy expenditure and, in DR offspring, decreased lipid utilization as a fuel substrate. By mid-adulthood, maternal Western diet DR offspring ate more chow, weighed more, and were fatter than controls. Thus, maternal Western diet covertly programmed increased adiposity in childhood and adulthood, disrupted relations of energy regulatory hormones with body fat, and decreased energy expenditure in offspring of lean, genetically obesity-resistant mothers. Maternal Western diet exposure alone, without maternal obesity or overnutrition, can promote offspring weight gain. Copyright © 2016 Frihauf et al.

Maternal Western diet increases adiposity even in male offspring of obesity-resistant rat dams: early endocrine risk markers

PubMed Central

Frihauf, Jennifer B.; Fekete, Éva M.; Nagy, Tim R.; Levin, Barry E.

2016-01-01

Maternal overnutrition or associated complications putatively mediate the obesogenic effects of perinatal high-fat diet on developing offspring. Here, we tested the hypothesis that a Western diet developmental environment increases adiposity not only in male offspring from obesity-prone (DIO) mothers, but also in those from obesity-resistant (DR) dams, implicating a deleterious role for the Western diet per se. Selectively bred DIO and DR female rats were fed chow (17% kcal fat) or Western diet (32%) for 54 days before mating and, thereafter, through weaning. As intended, despite chow-like caloric intake, Western diet increased prepregnancy weight gain and circulating leptin levels in DIO, but not DR, dams. Yet, in both genotypes, maternal Western diet increased the weight and adiposity of preweanlings, as early as in DR offspring, and increased plasma leptin, insulin, and adiponectin of weanlings. Although body weight normalized with chow feeding during adolescence, young adult Western diet offspring subsequently showed decreased energy expenditure and, in DR offspring, decreased lipid utilization as a fuel substrate. By mid-adulthood, maternal Western diet DR offspring ate more chow, weighed more, and were fatter than controls. Thus, maternal Western diet covertly programmed increased adiposity in childhood and adulthood, disrupted relations of energy regulatory hormones with body fat, and decreased energy expenditure in offspring of lean, genetically obesity-resistant mothers. Maternal Western diet exposure alone, without maternal obesity or overnutrition, can promote offspring weight gain. PMID:27654396

Inter-relationships among Diet, Obesity and Hippocampal-dependent Cognitive Function

PubMed Central

Davidson, Terry L.; Hargrave, Sara L.; Swithers, Susan E.; Sample, Camille H.; Fu, Xue; Kinzig, Kimberly P.; Zheng, Wei

2013-01-01

Intake of a Western diet (WD), which is high in saturated fat and sugar, is associated with deficits in hippocampal-dependent learning and memory processes as well as with markers of hippocampal pathology. In the present study, rats were trained to asymptote on hippocampal-dependent serial feature negative (FN) and hippocampal-independent simple discrimination problems. Performance was then assessed following 7 days on ad libitum chow and after 10, 24, 40, 60, and 90 days of maintenance on WD, on ketogenic (KETO) diet which is high in saturated fat and low in sugar and other carbohydrates, or continued maintenance on chow (CHOW). Confirming and extending previous findings, diet-induced obese (DIO) rats fed WD showed impaired FN performance, increased BBB permeability, and increased fasting blood glucose levels compared to CHOW controls and to diet resistant (DR) rats that did not become obese when maintained on WD. For rats fed the KETO diet, FN performance and BBB integrity was more closely associated with level of circulating ketone bodies than with obesity phenotype (DR or DIO) with higher levels of ketones appearing to provide a protective effect. The evidence also indicated that FN deficits preceded and predicted increased body weight and adiposity. This research (a) further substantiates previous findings of WD-induced deficits in hippocampal-dependent feature negative discriminations, (b) suggests that ketones may be protective against diet-induced cognitive impairment, and (c) provides evidence that diet-induced cognitive impairment precedes weight gain and obesity. PMID:23999121

GPA protects the nigrostriatal dopamine system by enhancing mitochondrial function.

PubMed

Horvath, Tamas L; Erion, Derek M; Elsworth, John D; Roth, Robert H; Shulman, Gerald I; Andrews, Zane B

2011-07-01

Guanidinopropionic acid (GPA) increases AMPK activity, mitochondrial function and biogenesis in muscle and improves physiological function, for example during aging. Mitochondrial dysfunction is a major contributor to the pathogenesis of Parkinson's disease. Here we tested whether GPA prevents neurodegeneration of the nigrostriatal dopamine system in MPTP-treated mice. Mice were fed a diet of 1% GPA or normal chow for 4 weeks and then treated with either MPTP or saline. Indices of nigrostriatal function were examined by HPLC, immunohistochemistry, stereology, electron microscopy and mitochondrial respiration. MPTP intoxication decreased TH neurons in the SNpc of normal chow-fed mice; however GPA-fed mice remarkably exhibited no loss of TH neurons in the SNpc. MPTP caused a decrease in striatal dopamine of both normal chow- and GPA-fed mice, although this effect was significantly attenuated in GPA-fed mice. GPA-fed mice showed increased AMPK activity, mitochondrial respiration and mitochondrial number in nigrostriatal TH neurons, suggesting that the neuroprotective effects of GPA involved AMPK-dependent increases in mitochondrial function and biogenesis. MPTP treatment produced a decrease in mitochondrial number and volume in normal chow-fed mice but not GPA-fed mice. Our results show the neuroprotective properties of GPA in a mouse model of Parkinson's disease are partially mediated by AMPK and mitochondrial function. Mitochondrial dysfunction is a common problem in neurodegeneration and thus GPA may slow disease progression in other models of neurodegeneration. Copyright © 2011 Elsevier Inc. All rights reserved.

Short-term exposure to a diet high in fat and sugar, or liquid sugar, selectively impairs hippocampal-dependent memory, with differential impacts on inflammation.

PubMed

Beilharz, J E; Maniam, J; Morris, M J

2016-06-01

Chronic high-energy diets are known to induce obesity and impair memory; these changes have been associated with inflammation in brain areas crucial for memory. In this study, we investigated whether inflammation could also be related to diet-induced memory deficits, prior to obesity. We exposed rats to chow, chow supplemented with a 10% sucrose solution (Sugar) or a diet high in fat and sugar (Caf+Sugar) and assessed hippocampal-dependent and perirhinal-dependent memory at 1 week. Both high-energy diet groups displayed similar, selective hippocampal-dependent memory deficits despite the Caf+Sugar rats consuming 4-5 times more energy, and weighing significantly more than the other groups. Extreme weight gain and excessive energy intake are therefore not necessary for deficits in memory. Weight gain across the diet period however, was correlated with the memory deficits, even in the Chow rats. The Sugar rats had elevated expression of a number of inflammatory genes in the hippocampus and WAT compared to Chow and Caf+Sugar rats but not in the perirhinal cortex or hypothalamus. Blood glucose concentrations were also elevated in the Sugar rats, and were correlated with the hippocampal inflammatory markers. Together, these results indicate that liquid sugar can rapidly elevate markers of central and peripheral inflammation, in association with hyperglycemia, and this may be related to the memory deficits in the Sugar rats. Copyright © 2016 Elsevier B.V. All rights reserved.

Effect of tocopherol on atherosclerosis, vascular function, and inflammation in apolipoprotein E knockout mice with subtotal nephrectomy.

PubMed

Shing, Cecilia M; Fassett, Robert G; Peake, Jonathan M; Coombes, Jeff S

2014-12-01

Inflammation and endothelial dysfunction contribute to cardiovascular disease, prevalent in chronic kidney disease (CKD). Antioxidant supplements such as tocopherols may reduce inflammation and atherosclerosis. This study aimed to investigate the effect of tocopherol supplementation on vascular function, aortic plaque formation, and inflammation in apolipoprotein E(-/-) mice with 5/6 nephrectomy as a model of combined cardiovascular and kidney disease. Nephrectomized mice were assigned to a normal chow diet group (normal chow), a group receiving 1000 mg/kg diet of α-tocopherol supplementation or a group receiving 1000 mg/kg diet mixed-tocopherol (60% γ-tocopherol). Following 12 weeks, in vitro aortic endothelial-independent relaxation was enhanced with both α-tocopherol and mixed-tocopherol (P < 0.05), while mixed-tocopherol enhanced aortic contraction at noradrenaline concentrations of 3 × 10(-7) M to 3 × 10(-5) M (P < 0.05), when compared to normal chow. Supplementation with α- and mixed-tocopherol reduced systemic concentrations of IL-6 (P < 0.001 and P < 0.001, respectively) and IL-10 (P < 0.05 and P < 0.001, respectively), while α-tocopherol also reduced MCP-1 (P < 0.05) and tumor necrosis factor (TNF)-α (P < 0.05). Aortic sinus plaque area was significantly reduced with α-tocopherol supplementation when compared to normal chow (P < 0.01). Tocopherol supplementation favorably influenced vascular function and cytokine profile, while it was also effective in reducing atherosclerosis in the apolipoprotein E(-/-) mouse with CKD. © 2014 John Wiley & Sons Ltd.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Panek, R.L.; Dixon, W.R.; Rutledge, C.O.

The effect of dietary lipid treatment on sympathetic neuronal function was examined in isolated perfused tail arteries of adult rats. The hypothesis that dietary manipulations alter the lipid environment of receptor proteins which may result in the perturbation of specific membrane-associated processes that regulate peripheral adrenergic neurotransmission in the vasculature was the basis for this investigation. In the present study, rats were fed semisynthetic diets enriched in either 16% coconut oil (saturated fat) or 16% sunflower oil (unsaturated fat). The field stimulation-evoked release of endogenous norepinephrine and total /sup 3/H was decreased significantly in rats receiving the coconut oil dietmore » when compared to either sunflower oil- or standard lab chow-fed rats. Norepinephrine content in artery segments from coconut oil-treated rats was significantly higher compared to either sunflower oil- or standard lab chow-fed rats. Tail arteries from rats receiving the coconut oil diet displayed significantly lower perfusion pressure responses to nerve stimulation at all frequencies tested when compared to the sunflower oil- or standard lab chow-fed rats. Vasoconstrictor responses of perfused tail arteries exposed to exogenous norepinephrine resulted in an EC50 for norepinephrine that was not changed by the dietary treatment, but adult rats receiving the sunflower oil diet displayed a significantly greater maximum response to exogenous norepinephrine (10(-5) M) compared to arteries from either coconut oil- or standard lab chow-fed rats.« less

KENNEDY SPACE CENTER, FLA. - A member of the Shoshone-Bannock Native American community from Fort Hall, Idaho, displays a handmade item with the STS-107 logo. Dancers from Shoshone-Bannock Junior-Senior High School performed a healing ceremony during the memorial held at the Space Memorial Mirror, in the KSC Visitor Complex. Feb. 1 is the one-year anniversary of the loss of the crew and orbiter Columbia in a tragic accident as the ship returned to Earth following mission STS-107. Students and staff of the Shoshone-Bannock Nation had an experiment on board Columbia. The public was invited to the memorial service, held in the KSC Visitor Complex, which included comments by Center Director Jim Kennedy and Executive Director of Florida Space Authority Winston Scott. Scott is a former astronaut who flew on Columbia in 1997.

NASA Image and Video Library

2004-02-01

KENNEDY SPACE CENTER, FLA. - A member of the Shoshone-Bannock Native American community from Fort Hall, Idaho, displays a handmade item with the STS-107 logo. Dancers from Shoshone-Bannock Junior-Senior High School performed a healing ceremony during the memorial held at the Space Memorial Mirror, in the KSC Visitor Complex. Feb. 1 is the one-year anniversary of the loss of the crew and orbiter Columbia in a tragic accident as the ship returned to Earth following mission STS-107. Students and staff of the Shoshone-Bannock Nation had an experiment on board Columbia. The public was invited to the memorial service, held in the KSC Visitor Complex, which included comments by Center Director Jim Kennedy and Executive Director of Florida Space Authority Winston Scott. Scott is a former astronaut who flew on Columbia in 1997.

KENNEDY SPACE CENTER, FLA. - KSC Deputy Director Woodrow Whitlow Jr. closes the memorial service held for the crew of Columbia at the Space Memorial Mirror in the KSC Visitor Complex. He is surrounded by dancers of the Shoshone-Bannock Native American community who performed a healing ceremony during the memorial. Feb. 1 is the one-year anniversary of the loss of the crew and orbiter Columbia in a tragic accident as the ship returned to Earth following mission STS-107. Students and staff of the Shoshone-Bannock Nation had an experiment on board Columbia. The public was invited to the memorial service, held in the KSC Visitor Complex, which included comments by Center Director Jim Kennedy and Executive Director of Florida Space Authority Winston Scott. Scott is a former astronaut who flew on Columbia in 1997.

NASA Image and Video Library

2004-02-01

KENNEDY SPACE CENTER, FLA. - KSC Deputy Director Woodrow Whitlow Jr. closes the memorial service held for the crew of Columbia at the Space Memorial Mirror in the KSC Visitor Complex. He is surrounded by dancers of the Shoshone-Bannock Native American community who performed a healing ceremony during the memorial. Feb. 1 is the one-year anniversary of the loss of the crew and orbiter Columbia in a tragic accident as the ship returned to Earth following mission STS-107. Students and staff of the Shoshone-Bannock Nation had an experiment on board Columbia. The public was invited to the memorial service, held in the KSC Visitor Complex, which included comments by Center Director Jim Kennedy and Executive Director of Florida Space Authority Winston Scott. Scott is a former astronaut who flew on Columbia in 1997.

KENNEDY SPACE CENTER, FLA. - Astronaut John Herrington speaks to the visitors at the memorial service held at the Space Memorial Mirror for the crew of Columbia. Herrington, who is a Chickasaw from Oklahoma, introduced the Shoshone-Bannock Junior-Senior High School dancers, from the Native American community at Fort Hall, Idaho, who performed a healing ceremony. Students and staff of the Shoshone-Bannock Nation had an experiment on board Columbia. Feb. 1 is the one-year anniversary of the loss of the crew and orbiter Columbia in a tragic accident as the ship returned to Earth following mission STS-107. The public was invited to the memorial service, held in the KSC Visitor Complex, which included comments by Center Director Jim Kennedy and Executive Director of Florida Space Authority Winston Scott. Scott is a former astronaut who flew on Columbia in 1997.

NASA Image and Video Library

2004-02-01

KENNEDY SPACE CENTER, FLA. - Astronaut John Herrington speaks to the visitors at the memorial service held at the Space Memorial Mirror for the crew of Columbia. Herrington, who is a Chickasaw from Oklahoma, introduced the Shoshone-Bannock Junior-Senior High School dancers, from the Native American community at Fort Hall, Idaho, who performed a healing ceremony. Students and staff of the Shoshone-Bannock Nation had an experiment on board Columbia. Feb. 1 is the one-year anniversary of the loss of the crew and orbiter Columbia in a tragic accident as the ship returned to Earth following mission STS-107. The public was invited to the memorial service, held in the KSC Visitor Complex, which included comments by Center Director Jim Kennedy and Executive Director of Florida Space Authority Winston Scott. Scott is a former astronaut who flew on Columbia in 1997.

Measuring Progress in Conflict Environments (MPICE): A Metrics Framework

DTIC Science & Technology

2010-06-04

offered by at- tendees at several peer review workshops held at the LBJ School of Public Affairs at the University of texas, the Carr Center at Harvard...at the Carr Center, Katherine Go- rove at the Center for Law and Military Operations, and Karen Guttieri at the naval Postgraduate School for their...in violent crime. QD, EK – Incidence of attacks or intimidation or discrimination against ex-combatants. QD, CA – Level of participation in the

Navy CG(X) Cruiser Program: Background, Oversight Issues, and Options for Congress

DTIC Science & Technology

2009-11-20

and Options for Congress 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d. PROJECT NUMBER 5e . TASK NUMBER 5f. WORK...Another press report (Katherine McIntire Peters, “Navy’s Top Officer Sees Lessons in Shipbuilding Program Failures,” GovernmentExecutive.com, September...whether the schedule for procuring CG(X)s is properly aligned with foreign-country ballistic missile development programs. A 2005 defense trade

Navy CG(X) Cruiser Program: Background, Oversight Issues, and Options for Congress

DTIC Science & Technology

2009-06-04

Options for Congress 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d. PROJECT NUMBER 5e . TASK NUMBER 5f. WORK UNIT...Inside the Navy, October 27, 2008. Another press report (Katherine McIntire Peters, “Navy’s Top Officer Sees Lessons in Shipbuilding Program...X)s could change.38 A related question is whether the schedule for procuring CG(X)s is properly aligned with foreign-country ballistic missile

Navy CG(X) Cruiser Program: Background, Oversight Issues, and Options for Congress

DTIC Science & Technology

2009-12-22

and Options for Congress 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d. PROJECT NUMBER 5e . TASK NUMBER 5f. WORK...press report (Katherine McIntire Peters, “Navy’s Top Officer Sees Lessons in Shipbuilding Program Failures,” GovernmentExecutive.com, September 24, 2008...changes would have led to a bigger problem—a future surface combatant force that was both unaffordable and poorly aligned with projected mission needs

Traumatic Brain Injury Screening: Preliminary Findings in a US Army Brigade Combat Team

DTIC Science & Technology

2009-01-01

Screening: Preliminary Findings in a US Army Brigade Combat Team Heidi Terrio, MD, MPH; Lisa A. Brenner, PhD; Brian J. Ivins, MS; John M. Cho, MD; Katherine...Sheila Saliman and Lisa Betthauser is greatly appreciated. Corresponding author: Heidi Terrio, MD, MPH, 1853 O’Connell Blvd, Bldg 1042, Room 107, Fort...more mild TBI symptoms among injured soldiers with and without TBI (n = 1208)∗,† Parameter Adjusted 95% CI adjusted Variable estimate (β) SE β Wald P

High Fat Diet Augments Amphetamine Sensitization in Mice: Role of Feeding Pattern, Obesity, and Dopamine Terminal Changes

PubMed Central

Fordahl, Steve C.; Locke, Jason L.; Jones, Sara R.

2016-01-01

High fat (HF) diet-induced obesity has been shown to augment behavioral responses to psychostimulants that target the dopamine system. The purpose of this study was to characterize dopamine terminal changes induced by a HF diet that correspond with enhanced locomotor sensitization to amphetamine. C57BL/6J mice had limited (2hr 3d/week) or extended (24h 7d/week) access to a HF diet or standard chow for six weeks. Mice were then repeatedly exposed to amphetamine (AMPH), and their locomotor responses to an amphetamine challenge were measured. Fast scan cyclic voltammetry was used to identify changes in dopamine terminal function after AMPH exposure. Exposure to a HF diet reduced dopamine uptake and increased locomotor responses to acute, high-dose AMPH administration compared to chow fed mice. Microdialysis showed elevated extracellular dopamine in the nucleus accumbens (NAc) coincided with enhanced locomotion after acute AMPH in HF-fed mice. All mice exhibited locomotor sensitization to amphetamine, but both extended and limited access to a HF diet augmented this response. Neither HF-fed group showed the robust amphetamine sensitization-induced increases in dopamine release, reuptake, and amphetamine potency observed in chow fed animals. However, the potency of amphetamine as an uptake inhibitor was significantly elevated after sensitization in mice with extended (but not limited) access to HF. Conversely, after amphetamine sensitization, mice with limited (but not extended) access to HF displayed reduced autoreceptor sensitivity to the D2/D3 agonist quinpirole. Additionally, we observed reduced membrane dopamine transporter (DAT) levels after HF, and a shift in DAT localization to the cytosol was detected with limited access to HF. This study showed that different patterns of HF exposure produced distinct dopamine terminal adaptations to repeated AMPH, which differed from chow fed mice, and enhanced sensitization to AMPH. Locomotor sensitization in chow fed mice

Effects of a herbal medicine, Hippophae rhamnoides, on cardiovascular functions and coronary microvessels in the spontaneously hypertensive stroke-prone rat.

PubMed

Koyama, Tomiyasu; Taka, Akira; Togashi, Hiroko

2009-01-01

The dry fruits of Hippophae rhamnoides (so-called "Saji" or "Sea buckthorn") are used in China as a herbal medicine. The present work studied the effects on microvessels in the left ventricular wall, hematological parameters, cardiovascular performance and plasma constituents in spontaneously hypertensive stroke-prone rats (SHRSP/EZO) treated with Hippophae for 60 days. Analyses showed that the powder made of dry Hippophae fruits contains the vitamins C, B1, B2 and E, provitamin A, rutin, serotonin, cytosterol, selenium and zinc, among other constituents. The experimental rats were fed ad libitum with blocks of rat chow supplemented with Hippophae powder at a concentration of 0.7 g/kg in rat powder chow, while control rats were unsupplemented chow. The mean arterial blood pressure, heart rate, total plasma cholesterol, triglycerides, and glycated hemoglobin were significantly decreased by the Hippophae treatment. The arteriolar capillary portions of microvessels expressing alkaline phosphatase decreased, but there was a trend for an increase in the total capillary density. It was concluded that Hippophae fruits improved the metabolic processes accompanied by reduction of hypertensive stress on the ventricular microvessels.

Oestradiol differentially influences feeding behaviour depending on diet composition in female rhesus monkeys

PubMed Central

Johnson, ZP; Lowe, J; Michopoulos, V; Moore, CJ; Wilson, ME; Toufexis, D

2015-01-01

In females, cyclical changes in the ovarian hormone oestradiol are known to modulate feeding behaviour. However, what is less clear is how these behavioural effects of oestradiol are modified by the macronutrient content of a diet. Here we present data showing that oestradiol treatment results in both significantly smaller meals and reduced total caloric intake in ovariectomised, socially housed female rhesus macaques when only chow diet is available. Conversely, during a choice dietary condition where both palatable and chow options are available, oestradiol treatment had no observable, attenuating effect on caloric intake. During this choice dietary phase, all animals consumed more of the palatable diet than chow diet; however, oestradiol treatment appeared to further increase preference for the palatable diet. Finally, oestradiol treatment increased snacking behaviour, i.e. consumption of calories outside of empirically defined meals, regardless of diet condition. These findings illustrate how oestradiol differentially influences feeding behaviour depending on the dietary environment and provides a framework in which we can begin to examine the mechanisms underlying these observed changes. PMID:23714578

High fructose corn syrup induces metabolic dysregulation and altered dopamine signaling in the absence of obesity.

PubMed

Meyers, Allison M; Mourra, Devry; Beeler, Jeff A

2017-01-01

The contribution of high fructose corn syrup (HFCS) to metabolic disorder and obesity, independent of high fat, energy-rich diets, is controversial. While high-fat diets are widely accepted as a rodent model of diet-induced obesity (DIO) and metabolic disorder, the value of HFCS alone as a rodent model of DIO is unclear. Impaired dopamine function is associated with obesity and high fat diet, but the effect of HFCS on the dopamine system has not been investigated. The objective of this study was to test the effect of HFCS on weight gain, glucose regulation, and evoked dopamine release using fast-scan cyclic voltammetry. Mice (C57BL/6) received either water or 10% HFCS solution in combination with ad libitum chow for 15 weeks. HFCS consumption with chow diet did not induce weight gain compared to water, chow-only controls but did induce glucose dysregulation and reduced evoked dopamine release in the dorsolateral striatum. These data show that HFCS can contribute to metabolic disorder and altered dopamine function independent of weight gain and high-fat diets.

High fructose corn syrup induces metabolic dysregulation and altered dopamine signaling in the absence of obesity

PubMed Central

2017-01-01

The contribution of high fructose corn syrup (HFCS) to metabolic disorder and obesity, independent of high fat, energy-rich diets, is controversial. While high-fat diets are widely accepted as a rodent model of diet-induced obesity (DIO) and metabolic disorder, the value of HFCS alone as a rodent model of DIO is unclear. Impaired dopamine function is associated with obesity and high fat diet, but the effect of HFCS on the dopamine system has not been investigated. The objective of this study was to test the effect of HFCS on weight gain, glucose regulation, and evoked dopamine release using fast-scan cyclic voltammetry. Mice (C57BL/6) received either water or 10% HFCS solution in combination with ad libitum chow for 15 weeks. HFCS consumption with chow diet did not induce weight gain compared to water, chow-only controls but did induce glucose dysregulation and reduced evoked dopamine release in the dorsolateral striatum. These data show that HFCS can contribute to metabolic disorder and altered dopamine function independent of weight gain and high-fat diets. PMID:29287121

Dietary Uncoupling of Gut Microbiota and Energy Harvesting from Obesity and Glucose Tolerance in Mice.

PubMed

Dalby, Matthew J; Ross, Alexander W; Walker, Alan W; Morgan, Peter J

2017-11-07

Evidence suggests that altered gut microbiota composition may be involved in the development of obesity. Studies using mice made obese with refined high-fat diets have supported this; however, these have commonly used chow as a control diet, introducing confounding factors from differences in dietary composition that have a key role in shaping microbiota composition. We compared the effects of feeding a refined high-fat diet with those of feeding either a refined low-fat diet or a chow diet on gut microbiota composition and host physiology. Feeding both refined low- or high-fat diets resulted in large alterations in the gut microbiota composition, intestinal fermentation, and gut morphology, compared to a chow diet. However, body weight, body fat, and glucose intolerance only increased in mice fed the refined high-fat diet. The choice of control diet can dissociate broad changes in microbiota composition from obesity, raising questions about the previously proposed relationship between gut microbiota and obesity. Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.

Afghanistan: A War That Can Only Be Won via the Concentration of United States Elements of National Power

DTIC Science & Technology

2008-04-04

millions of Afghan refugees who fled the 16 Christopher S. Wren , “Soviet is Assailed on Afghan Policy...Only when two nations share a common interest, will an alliance succeed to its fullest potential. During World War II, Sir Winston Churchill...strong ideological support of the Nazi party and supporting military infrastructure, perhaps best represents the scale and scope of today’s enemy. Sir

Desferrioxamine for Stimulation of Fracture Healing and Revascularization in a Bone Defect Model

DTIC Science & Technology

2012-02-01

cartilaginous tissue still present. DBM + L-DFO: Fracture gap less evident with more complete bone bridging with denser trabecular bone and less...fracture callus volume by micro-CT, and qualitative histology for callus tissue quality and vascularity in 5 groups (No implant, CS implant, DFO+CS...Weinhold, P. North Carolina Tissue Engineering and Regenerative Medicine Meeting, November 4, 2011; Winston Salem, NC. (presented) • Desferroxamine with

The Roles of the Bone Marrow Microenvironment in Controlling Tumor Dormancy

DTIC Science & Technology

2015-10-01

Shiozawa, M.D., Ph.D. CONTRACTING ORGANIZATION: Wake Forest School of Medicine Ann Arbor, MI 48109 REPORT DATE: October 2015 TYPE OF REPORT...PERFORMING ORGANIZATION REPORT NUMBER Wake Forest University Health Sciences Medical Center Blvd. Winston-Salem NC 27157 9. SPONSORING... Wake Forest School of Medicine as of 03/01/15. The PI obtained the necessary institutional approvals (IACUC, IRB, IBC) and submitted the grant

Matching Jobs, People, and Instructional Content: An Innovative Application of a Latent Semantic Analysis-Based Technology

DTIC Science & Technology

2003-03-01

information technologies that can: (a) represent knowledge and skills, (b) identify people with all or parts of the knowledge and task experience...needed but lacked, A might be at too advanced a level for the 8 individual to understand given his or her previous knowledge , B might overlap too...SEMANTIC ANALYSIS-BASED TECHNOLOGY Darrell Laham Knowledge Analysis Technologies 4940 Pearl East Circle #200 Boulder, CO 80301 Winston

Repairing Learned Knowledge Using Experience

DTIC Science & Technology

1990-05-01

34 Artifcial Intelligence Journal, vol. 19, no. 3. Winston, Patrick Henry (1984], Artificial Intelligence , Second Edition, Addison-Wesley. Analogical...process speeds up future problem solving, but the scope of the learni ng- augmented theory remains unchanged. In con- (continued on back) PD D J7 1473...Distribution/ Avaiability Codes Avail and/or .Dist Special MASSACHUSETTS INSTITUTE OF TECHNOLOGY ARTIFICIAL INTELLIGENCE LABORATORY A.I. Memo No. 1231

SU-E-J-48: Imaging Origin-Radiation Isocenter Coincidence for Linac-Based SRS with Novalis Tx

DOE Office of Scientific and Technical Information (OSTI.GOV)

Geraghty, C; Workie, D; Hasson, B

Purpose To implement and evaluate an image-based Winston-Lutz (WL) test to measure the displacement between ExacTrac imaging origin and radiation isocenter on a Novalis Tx system using RIT V6.2 software analysis tools. Displacement between imaging and radiation isocenters was tracked over time. The method was applied for cone-based and MLC-based WL tests. Methods The Brainlab Winston-Lutz phantom was aligned to room lasers. The ExacTrac imaging system was then used to detect the Winston- Lutz phantom and obtain the displacement between the center of the phantom and the imaging origin. EPID images of the phantom were obtained at various gantry andmore » couch angles and analyzed with RIT calculating the phantom center to radiation isocenter displacement. The RIT and Exactrac displacements were combined to calculate the displacement between imaging origin and radiation isocenter. Results were tracked over time. Results Mean displacements between ExacTrac origin and radiation isocenter were: VRT: −0.1mm ± 0.3mm, LNG: 0.5mm ± 0.2mm, LAT: 0.2mm ± 0.2mm (vector magnitude of 0.7 ± 0.2mm). Radiation isocenter was characterized by the mean of the standard deviations of the WL phantom displacements: σVRT: 0.2mm, σLNG: 0.4mm, σLAT: 0.6mm. The linac couch base was serviced to reduce couch walkout. This reduced σLAT to 0.2mm. These measurements established a new baseline of radiation isocenter-imaging origin coincidence. Conclusion The image-based WL test has ensured submillimeter localization accuracy using the ExacTrac imaging system. Standard deviations of ExacTrac-radiation isocenter displacements indicate that average agreement within 0.3mm is possible in each axis. This WL test is a departure from the tradiational WL in that imaging origin/radiation isocenter agreement is the end goal not lasers/radiation isocenter.« less

Quality assurance for a six degrees-of-freedom table using a 3D printed phantom.

PubMed

Woods, Kyle; Ayan, Ahmet S; Woollard, Jeffrey; Gupta, Nilendu

2018-01-01

To establish a streamlined end-to-end test of a 6 degrees-of-freedom (6DoF) robotic table using a 3D printed phantom for periodic quality assurance. A 3D printed phantom was fabricated with translational and rotational offsets and an imbedded central ball-bearing (BB). The phantom underwent each step of the radiation therapy process: CT simulation in a straight orientation, plan generation using the treatment planning software, setup to offset marks at the linac, registration and corrected 6DoF table adjustments via hidden target test, delivery of a Winston-Lutz test to the BB, and verification of table positioning via field and laser lights. The registration values, maximum total displacement of the combined Winston-Lutz fields, and a pass or fail criterion of the laser and field lights were recorded. The quality assurance process for each of the three linacs were performed for the first 30 days. Within a 95% confidence interval, the overall uncertainty values for both translation and rotation were below 1.0 mm and 0.5° for each linac respectively. When combining the registration values and other uncertainties for all three linacs, the average deviations were within 2.0 mm and 1.0° of the designed translation and rotation offsets of the 3D print respectively. For all three linacs, the maximum total deviation for the Winston-Lutz test did not exceed 1.0 mm. Laser and light field verification was within tolerance every day for all three linacs given the latest guidance documentation for table repositioning. The 3D printer is capable of accurately fabricating a quality assurance phantom for 6DoF positioning verification. The end-to-end workflow allows for a more efficient test of the 6DoF mechanics while including other important tests needed for routine quality assurance. © 2017 The Authors. Journal of Applied Clinical Medical Physics published by Wiley Periodicals, Inc. on behalf of American Association of Physicists in Medicine.

SU-E-J-213: Imaging and Treatment Isocenter Verification of a Gantry Mounted Proton Therapy System

DOE Office of Scientific and Technical Information (OSTI.GOV)

Price, S; Goddu, S; Rankine, L

2014-06-01

Purpose: The Mevion proton therapy machine is the first to feature a gantry mounted sychro-cyclotron. In addition, the system utilizes a 6D motion couch and kV imaging for precise proton therapy. To quantify coincidence between these systems, isocentricity tests were performed based on kV imaging alignment using radiochromic film. Methods: The 100 ton gantry and 6D robotic couch can rotate 190° around isocenter to provide necessary beam angles for treatment. The kV sources and detector panels are deployed as needed to acquire orthogonal portals. Gantry and couch mechanical isocenter were tested using star-shots and radiochromic-film (RCF). Using kV imaging, themore » star-shot phantom was aligned to an embedded fiducial and the isocenter was marked on RCF with a pinprick. The couch and gantry stars were performed by irradiating films at every 45° and 30°, respectively. A proton beam with a range and modulation-width of 18 cm was used. A Winston-Lutz test was also performed at the same gantry and couch rotations using a custom jig holding RCF and a tungsten ball placed at isocenter. A 2 cm diameter circular aperture was used for the irradiation. Results: The couch star-shot indicated a minimum tangent circle of 0.6 mm, with a 0.9 mm offset from the manually marked isocenter. The gantry star-shot showed a 0.6 mm minimum tangent circle with a 0.5 mm offset from the pinprick. The Winston Lutz test performed for gantry rotation showed a maximum deviation from center of 0.5 mm. Conclusion: Based on star-shots and Winston-Lutz tests, the proton gantry and 6D couch isocentricity are within 1 mm. In this study, we have shown that the methods commonly utilized for Linac characterization can be applied to proton therapy. This revolutionary proton therapy system possesses excellent agreement between the mechanical and radiation isocenter, providing highly precise treatment.« less

Dietary deficiency of vitamin E aggravates retinal ganglion cell death in experimental glaucoma of rats.

PubMed

Ko, Mei-Lan; Peng, Pai-Huei; Hsu, Shens-Yao; Chen, Chau-Fong

2010-09-01

Investigate the effect of dietary vitamin E (Vit E) on the retinas of a rat model of induced glaucoma, in which surgically induced elevation of intraocular pressure (IOP) is associated with an increase in reactive oxygen species. Rats were fed a standard chow, Vit E-supplemented diet, or Vit E-deficient diet and subjected to surgically induced IOP elevation (or sham surgery) for five weeks. The retinal ganglion cells (RGCs) were subjected to retrograde fluorescent tracer labeling. The mean number of RGCs of rats on the standard chow, Vit E-supplemented diet, and Vit E-deficient diet were 79.6%, 78.6%, and 71.3% of controls, respectively. Lipid peroxidation of the retinas of rats given a Vit E-deficient diet were significantly higher after IOP elevation for three days (14.42 +/- 0.25 microM, P = 0.016) and five weeks (10.46 +/- 0.11 microM, p = 0.042), compared to rats given standard chow (11.37 +/- 0.31 microM; 8.95 +/- 0.16 microM). Compared with rats given standard chow, rats given a Vit E-deficient diet had significantly elevated concentrations of glutathione (p = 0.032), but no significant differences in the levels of total superoxide dismutase (SOD), Cu/Zn SOD, or catalase activities three days after IOP elevation. Rats fed a Vit E-deficient diet with surgically induced IOP elevation experience significantly more RGC death than rats fed a normal diet. This phenomenon may be related to the increased level of lipid peroxidation in Vit E-deficient rats.

Neural Basis of Ventromedial Hypothalamic Oxytocin-Driven Decrease in Appetite.

PubMed

Klockars, Oscar A; Waas, Joseph R; Klockars, Anica; Levine, Allen S; Olszewski, Pawel K

2017-12-16

Oxytocin (OT) administration in the ventromedial hypothalamic nucleus (VMH) reduces chow intake. The nature of VMH OT's anorexigenic action remains unclear. Here we provide insight into neural mechanisms underlying VMH OT-driven anorexia by (a) identifying feeding-related brain sites activated by VMH OT injection; (b) measuring VMH OT receptor (OTr) mRNA changes in response to hunger and palatability; and (c) examining how VMH OT affects episodic sweet solution intake in sated and hungry rats. We established effective doses of VMH OT in deprivation-induced and scheduled feeding and determined whether an OT antagonist blocks the effect. Then, OT (or antagonist) was injected in the VMH of sated rats given episodically sucrose and saccharin solutions. OT was also injected in hungry animals offered simultaneously chow and sugar water. Brain activation after VMH OT was determined by Fos immunoreactivity (IR). OTr expression was established with rtPCR after chow deprivation or saccharin exposure. VMH OT decreased intake of chow and the effect was reversed by the antagonist, though the antagonist alone was not orexigenic. OT did not affect intakes of energy-dilute saccharin and sucrose solutions in sated or hungry rats. Fos IR was elevated in the VMH and energy balance-related paraventricular and arcuate nuclei, but not reward areas. VMH OTr expression was higher in hungry rats than in sated controls; saccharin intake had no effect. OT acting in the VMH decreases intake driven by energy not by palatability, and it stimulates activity of hypothalamic sites controlling energy balance. Copyright © 2017 IBRO. Published by Elsevier Ltd. All rights reserved.

Inter-relationships among diet, obesity and hippocampal-dependent cognitive function.

PubMed

Davidson, T L; Hargrave, S L; Swithers, S E; Sample, C H; Fu, X; Kinzig, K P; Zheng, W

2013-12-03

Intake of a Western diet (WD), which is high in saturated fat and sugar, is associated with deficits in hippocampal-dependent learning and memory processes as well as with markers of hippocampal pathology. In the present study, rats were trained to asymptote on hippocampal-dependent serial feature negative (FN) and hippocampal-independent simple discrimination problems. Performance was then assessed following 7 days on ad libitum chow and after 10, 24, 40, 60, and 90 days of maintenance on WD, on ketogenic (KETO) diet, which is high in saturated fat and low in sugar and other carbohydrates, or continued maintenance on chow (CHOW). Confirming and extending previous findings, diet-induced obese (DIO) rats fed WD showed impaired FN performance, increased blood-brain barrier (BBB) permeability, and increased fasting blood glucose levels compared to CHOW controls and to diet-resistant (DR) rats that did not become obese when maintained on WD. For rats fed the KETO diet, FN performance and BBB integrity were more closely associated with level of circulating ketone bodies than with obesity phenotype (DR or DIO), with higher levels of ketones appearing to provide a protective effect. The evidence also indicated that FN deficits preceded and predicted increased body weight and adiposity. This research (a) further substantiates previous findings of WD-induced deficits in hippocampal-dependent FN discriminations, (b) suggests that ketones may be protective against diet-induced cognitive impairment, and (c) provides evidence that diet-induced cognitive impairment precedes weight gain and obesity. Copyright © 2013 IBRO. Published by Elsevier Ltd. All rights reserved.

Effects of a free-choice high-fat high-sugar diet on brain PER2 and BMAL1 protein expression in mice.

PubMed

Blancas-Velazquez, Aurea; la Fleur, Susanne E; Mendoza, Jorge

2017-10-01

The suprachiasmatic nucleus (SCN) times the daily rhythms of behavioral processes including feeding. Beyond the SCN, the hypothalamic arcuate nucleus (ARC), involved in feeding regulation and metabolism, and the epithalamic lateral habenula (LHb), implicated in reward processing, show circadian rhythmic activity. These brain oscillators are functionally coupled to coordinate the daily rhythm of food intake. In rats, a free choice high-fat high-sugar (fcHFHS) diet leads to a rapid increase of calorie intake and body weight gain. Interestingly, under a fcHFHS condition, rats ingest a similar amount of sugar during day time (rest phase) as during night time (active phase), but keep the rhythmic intake of regular chow-food. The out of phase between feeding patterns of regular (chow) and highly rewarding food (sugar) may involve alterations of brain circadian oscillators regulating feeding. Here, we report that the fcHFHS diet is a successful model to induce calorie intake, body weight gain and fat tissue accumulation in mice, extending its effectiveness as previously reported in rats. Moreover, we observed that whereas in the SCN the day-night difference in the PER2 clock protein expression was similar between chow-fed and fcHFHS-fed animals, in the LHb, this day-night difference was altered in fcHFHS-exposed animals compared to control chow mice. These findings confirm previous observations in rats showing disrupted daily patterns of feeding behavior under a fcHFHS diet exposure, and extend our insights on the effects of the diet on circadian gene expression in brain clocks. Copyright © 2017 Elsevier Ltd. All rights reserved.

Increased adult hippocampal neurogenesis is not necessary for wheel running to abolish conditioned place preference for cocaine in mice.

PubMed

Mustroph, M L; Merritt, J R; Holloway, A L; Pinardo, H; Miller, D S; Kilby, C N; Bucko, P; Wyer, A; Rhodes, J S

2015-01-01

Recent evidence suggests that wheel running can abolish conditioned place preference (CPP) for cocaine in mice. Running significantly increases the number of new neurons in the hippocampus, and new neurons have been hypothesised to enhance plasticity and behavioral flexibility. Therefore, we tested the hypothesis that increased neurogenesis was necessary for exercise to abolish cocaine CPP. Male nestin-thymidine kinase transgenic mice were conditioned with cocaine, and then housed with or without running wheels for 32 days. Half of the mice were fed chow containing valganciclovir to induce apoptosis in newly divided neurons, and the other half were fed standard chow. For the first 10 days, mice received daily injections of bromodeoxyuridine (BrdU) to label dividing cells. On the last 4 days, mice were tested for CPP, and then euthanized for measurement of adult hippocampal neurogenesis by counting the number of BrdU-positive neurons in the dentate gyrus. Levels of running were similar in mice fed valganciclovir-containing chow and normal chow. Valganciclovir significantly reduced the numbers of neurons (BrdU-positive/NeuN-positive) in the dentate gyrus of both sedentary mice and runner mice. Valganciclovir-fed runner mice showed similar levels of neurogenesis as sedentary, normal-fed controls. However, valganciclovir-fed runner mice showed the same abolishment of CPP as runner mice with intact neurogenesis. The results demonstrate that elevated adult hippocampal neurogenesis resulting from running is not necessary for running to abolish cocaine CPP in mice. © 2014 Federation of European Neuroscience Societies and John Wiley & Sons Ltd.

Chronic moderate alcohol consumption relieves high-fat high-cholesterol diet-induced liver fibrosis in a rat model.

PubMed

Sun, Furong; Zhuang, Zhenjie; Zhang, Dai; Chen, Yushuai; Liu, Shu; Gao, Nan; Shi, Junping; Wang, Bingyuan

2018-05-30

Nonalcoholic fatty liver disease is a worldwide health issue and chronic alcohol consumption may have different effects on this disease. This study explored the role of chronic moderate alcohol consumption on high-fat high-cholesterol (HFHC) diet-induced liver fibrosis in a rodent model. Male Sprague-Dawley rats were divided into five groups: standard chow group, standard chow plus Er Guo Tou (EGT, a Chinese spirits made from fermented cereals) group, HFHC group, HFHC plus EGT group, and HFHC plus pure ethanol group. Rats were fed standard chow or HFHC chow for 12 weeks. EGT or pure ethanol was administrated at a daily dose of 4 g/kg body weight via intra-gastric gavage from the week four. At the end of week 12, hematoxylin and eosin staining, Sirius red and immunohistochemistry of liver sections were examined. The hepatic expression of F4/80, TNF-α, IL-1β, IL-6, CXCL1, CXCL2, α-SMA, Collagen, TGF-β, MMP2, MMP9, and TIMP1 was calculated. Both moderate EGT and pure ethanol did not increase plasma endotoxin in the portal vein comparing with the FHFC group. EGT and pure ethanol did not improve hepatic inflammation, but ameliorated liver fibrosis in histology. Moderate EGT and pure ethanol ameliorated HFHC diet-induced activation of Kupffer cells and hepatic stellate cells. In conclusion, chronic moderate EGT and pure ethanol could ameliorate HFHC diet-induced liver fibrosis. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.

Gastric Bypass in Rats Does Not Decrease Appetitive Behavior Towards Sweet or Fatty Fluids Despite Blunting Preferential Intake of Sugar and Fat

PubMed Central

Mathes, Clare M.; Bohnenkamp, Ryan A.; Blonde, Ginger D.; Letourneau, Chanel; Corteville, Caroline; Bueter, Marco; Lutz, Thomas A.; le Roux, Carel W.; Spector, Alan C.

2015-01-01

After Roux-en-Y gastric bypass surgery (RYGB), patients report consuming fewer fatty and dessert-like foods, and rats display blunted sugar and fat preferences. Here we used a progressive ratio task (PR) in our rat model to explicitly test whether RYGB decreases the willingness of rats to work for very small amounts of preferred sugar- and/or fat-containing fluids. In each of two studies, two groups of rats - one maintained on a high-fat diet (HFD) and standard chow (CHOW) and one given CHOW alone - were trained while water-deprived to work for water or either Ensure or 1.0 M sucrose on increasingly difficult operant schedules. When tested before surgery while nondeprived, HFD rats had lower PR breakpoints (number of operant responses in the last reinforced ratio) for sucrose, but not for Ensure, than CHOW rats. After surgery, at no time did rats given RYGB show lower breakpoints than SHAM rats for Ensure, sucrose, or when 5% Intralipid served postoperatively as the reinforcer. Nevertheless, RYGB rats showed blunted preferences for these caloric fluids versus water in 2-bottle preference tests. Importantly, although the Intralipid and sucrose preferences of RYGB rats decreased further over time, subsequent breakpoints for them were not significantly impacted. Collectively, these data suggest that the observed lower preferences for normally palatable fluids after RYGB in rats may reflect a learned adjustment to altered postingestive feedback rather than a dampening of the reinforcing taste characteristics of such stimuli as measured by the PR task in which postingestive stimulation is negligible. PMID:25660341

Maternal obesity increases inflammation and exacerbates damage following neonatal hypoxic-ischaemic brain injury in rats.

PubMed

Teo, Jonathan D; Morris, Margaret J; Jones, Nicole M

2017-07-01

In humans, maternal obesity is associated with an increase in the incidence of birth related difficulties. However, the impact of maternal obesity on the severity of brain injury in offspring is not known. Recent studies have found evidence of increased glial response and inflammatory mediators in the brains as a result of obesity in humans and rodents. We hypothesised that hypoxic-ischaemic (HI) brain injury is greater in neonatal offspring from obese rat mothers compared to lean controls. Female Sprague Dawley rats were randomly allocated to high fat (HFD, n=8) or chow (n=4) diet and mated with lean male rats. On postnatal day 7 (P7), male and female pups were randomly assigned to HI injury or control (C) groups. HI injury was induced by occlusion of the right carotid artery followed by 3h exposure to 8% oxygen, at 37°C. Control pups were removed from the mother for the same duration under ambient conditions. Righting behaviour was measured on day 1 and 7 following HI. The extent of brain injury was quantified in brain sections from P14 pups using cresyl violet staining and the difference in volume between brain hemispheres was measured. Before mating, HFD mothers were 11% heavier than Chow mothers (p<0.05, t-test). Righting reflex was delayed in offspring from HFD-fed mothers compared to the Chow mothers. The Chow-HI pups showed a loss in ipsilateral brain tissue, while the HFD-HI group had significantly greater loss. No significant difference was detected in brain volume between the HFD-C and Chow-C pups. When analysed on a per litter basis, the size of the injury was significantly correlated with maternal weight. Similar observations were made with neuronal staining showing a greater loss of neurons in the brain of offspring from HFD-mothers following HI compared to Chow. Astrocytes appeared to more hypertrophic and a greater number of microglia were present in the injured hemisphere in offspring from mothers on HFD. HI caused an increase in the proportion of

Sir Winston Churchill: treatment for pneumonia in 1943 and 1944.

PubMed

Vale, J A; Scadding, J W

2017-12-01

This paper reviews Churchill's illnesses in February 1943 and August/September 1944 when he developed pneumonia; on the first occasion this followed a cold and sore throat. Churchill was managed at home by Sir Charles Wilson (later Lord Moran) with the assistance of two nurses and the expert advice of Dr Geoffrey Marshall, Brigadier Lionel Whitby and Colonel Robert Drew. A sulphonamide (sulphathiazole on the first occasion) was prescribed for both illnesses. Churchill recovered, and despite his illnesses continued to direct the affairs of State from his bed. On the second occasion, Churchill's illness was not made public.

Major Robert Lawrence Memorial Tribute

NASA Image and Video Library

2017-12-08

During an Astronauts Memorial Foundation tribute honoring U.S. Air Foce Maj. Robert Lawrence, vocalist Marva King sings with the Winston Scott “Cosmic Jazz Ensemble.” Selected in 1967 for the Manned Orbiting Laboratory Program, Lawrence was the first African-American astronaut. He lost his life in a training accident 50 years ago. The ceremony took place in the Center for Space Education at the Kennedy Space Center Visitor Complex.

STS-72 crew trains in Fixed Base (FB) Shuttle Mission Simulator (SMS)

NASA Image and Video Library

1995-06-07

S95-12716 (May 1995) --- Astronauts Brian Duffy, in commander's seat, and Winston E. Scott discuss their scheduled flight aboard the Space Shuttle Endeavour. The two are on the flight deck of the Johnson Space Center's (JSC) fixed base Shuttle Mission Simulator (SMS). Duffy, mission commander, and Scott, mission specialist, will be joined for the winter flight by three other NASA astronauts and an international mission specialist representing NASDA.

Adaptive Motivation Theory.

DTIC Science & Technology

1982-02-01

psychology (Vol. 2). ’ew York: Academic Press, 1965. Alderfer , C . P. Existencerelatedness, and growth: Human needs in organizational settings. New York: Free...Erikson, E . H. Identity, youth, and crisis. New York: Norton, 1968. Gagne, R . M. The conditions of learning. New York: Holt, Rinheart, and Winston, 1965...Reasoning, problem solving, and inceligenct. Handbook of Human Intelligence, in press. rolman, E . C . There is more than one kind of learning. Pschological

US--Soviet Combined Operations: Can We Do It?

DTIC Science & Technology

1991-06-01

Gribkov, 3. 86 Vasili I. Chuikov, The Fall of Berlin (Moscow: October magazine, 1965, trans. Ruth Kisch, Chicago: Holt, Rinehart and Winston, 1967), 65...work appears to be required in developing specific comparisons which pit Soviet concepts against US concepts to identify the differences and...Afghanistan: The First Five Years of Soviet Occupation. Washington, D.C.: National Defense University, 1986. Chuikov, Vasili I. The Fall of Berlin. With

Measuring Patient Satisfaction as a Basis for Medical Marketing and Strategic Planning

DTIC Science & Technology

1989-12-01

34 MdicalCare, 147: 86-90 (January 1979).4 Mowen, John C. Consumer Behavior . New York: MacMillan Publishing Company, 1987. Oliver, Richard L. and...34 Evaluation and Program Plannlng. 6: 247-263 (1983). Winston, William J. Health Marketing and Consumer Behavior . New York: Hawthorn Press, 1985. 95 Woodruff...indicator of the structure, process, and outcomes of care. Second, satisfaction data have been used as independent variables to predict consumer

Endocrinological Responses to the Administration of Nicotine: Interactions with Drug Initiation, Conditioned Effects, and Conditions of Stress, Volume II

DTIC Science & Technology

1984-01-07

Benowitz, Kuyt and Jacob, 1982; Feyerabend S Russe l l , 1978). 273 10 Measurement of hematocrit was performed as follows: 1) after centrifugation of...Incentives, Washington, D.C.: Winston. Feyerabend , C. , & Russell, M. A. H. (1978). Effect of urinary pH and nicotine excretion rate can plasma...s Feyerabend , c. (1978). Cigarette smoking: A dependence on high-nicotine boll. Drug Metabolism Review, 8_, 29-57. Russell, M. A. H. , Wilson, C

Contracting as a Science

DTIC Science & Technology

2012-04-30

behavioral research (3rd ed.). New York, NY: Holt, Reinhart & Winston. Kettl, D. F. (1993). Sharing power: Public governance and private markets . Washington...seek NPS faculty research supporting the interests of our program sponsors. Finally, we serve as a “broker” to market specific research topics...is a set of general philosophical assumptions, shared by researchers in a specific field or discipline, about the character of the world and how we

Contracting As A Science

DTIC Science & Technology

2012-04-30

behavioral research (3rd ed.). New York, NY: Holt, Reinhart & Winston. Kettl, D. F. (1993). Sharing power: Public governance and private markets . Washington...seek NPS faculty research supporting the interests of our program sponsors. Finally, we serve as a “broker” to market specific research topics...is a set of general philosophical assumptions, shared by researchers in a specific field or discipline, about the character of the world and how we

Method for Processing Liver Spheroids Using an Automatic Tissue Processor

DTIC Science & Technology

2016-05-01

Harry; Kristovich, Robert L. (ECBC); and Valdes, Leah R. (ORISE) 5d. PROJECT NUMBER CRADA 1314C w/ Wake Forest University 5e. TASK NUMBER 5f. WORK...The work described in this report was authorized under project no. CRADA1314C with Wake Forest University Health Sciences. The work was started in... Wake Forest Institute for Regenerative Medicine Winston-Salem, NC iv Blank v CONTENTS 1. INTRODUCTION

STS-87 Day 12 Highlights

NASA Technical Reports Server (NTRS)

1997-01-01

On this twelfth day of the STS-87 mission, the flight crew, Cmdr. Kevin R. Kregel, Pilot Steven W. Lindsey, Mission Specialists Winston E. Scott, Kalpana Chawla, and Takao Doi, and Payload Specialist Leonid K. Kadenyuk continue to look at how plant growth and composite materials are affected by microgravity. The astronauts use the globebox facility to process samples for the Particle Engulfment and Pushing by a Solid/Liquid Interface experiment.

STS-87 Day 10 Highlights

NASA Technical Reports Server (NTRS)

1997-01-01

On this tenth day of the STS-87 mission, the flight crew, Cmdr. Kevin R. Kregel, Pilot Steven W. Lindsey, Mission Specialists Winston E. Scott, Kalpana Chawla, and Takao Doi, and Payload Specialist Leonid K. Kadenyuk receive a call from Ukrainian President Leonid Kuchma and answer questions from media in Kiev. The conversations focus on Kadenyuk's first flight into space and the work ongoing to support the mission objectives.

STS-87 Day 04 Highlights

NASA Technical Reports Server (NTRS)

1997-01-01

On this fourth day of the STS-87 mission, the flight crew, Cmdr. Kevin R. Kregel, Pilot Steven W. Lindsey, Mission Specialists Winston E. Scott, Kalpana Chawla, and Takao Doi, and Payload Specialist Leonid K. Kadenyuk check out the spacesuits for the EVA planned for later during the mission. Mission Control developed plans that may allow Scott and Doi to recapture the Spartan satellite by hand during that EVA.

A Historical Perspective of Special Operations Forces as an Instrument of Strategy.

DTIC Science & Technology

1991-01-01

government of Winston Churchill had ascended to power. For the special operations effort, fits and starts toward a more capable organization had occurred...therefore reasonable to conclude that this halting method of agent and organization development though time- consuming , eventually provided a cadre of...Command and General Staff College, Ft. Leavenworth, KS. July 21, 1999. THIS PAGE IS UNCLASSIFIED AD-B 158 452 A HISTORICAL PERSPECTIVE OF ’ SPECIAL

Acquiring Procedural Skills from Lesson Sequences.

DTIC Science & Technology

1985-08-13

Teachers of Mathematics . Washington, D)C: NCTM . Brueckner, I..J. (1930) Diagnostic aund remedial teaching in arithmetic. Philadelphia. PA: Winston. Burton...arithmetic and algebra, fr-m multi-lesson curricula. The central hypothesis is that students and teachers obey cc: :-.entions that cause the goal hierarchy...students and • . teachers obey conventions that cause the goal hierarchy of the acquired procedure to be a particular structural function of the sequential

Columbia Quilt

NASA Image and Video Library

2018-02-22

A certificate is on display that confirms the transfer of a giant hand-made quilt in honor of space shuttle Columbia and her crew from the Office of Procurement to the Columbia Preservation Room inside the Vehicle Assembly Building at NASA's Kennedy Space Center in Florida. The quilt was made by Katherine Walsh, a lifelong NASA and space program fan originally from Kentucky. The quilt will be displayed with its certificate in the preservation room as part of NASA's Apollo, Challenger, Columbia Lessons Learned Program.

Determine the Role of Canonical Wnt Signaling in Ovarian Tumorigenesis

DTIC Science & Technology

2012-10-01

Acad Sci U S A, 1999. 96(4): p. 1603-8. 11. Kuilman, T., et al., The essence of senescence. Genes Dev, 2010. 24(22): p. 2463- 79. 12. Bernardi, R...Tu,1 Katherine M. Aird,1 Benjamin G. Bitler,1 Jasmine P. Nicodemus,1 Neil Beeharry,2 Bing Xia,3 Tim J. Yen,2 and Rugang Zhang1,2,* 1Women’s Cancer...Bitler, Jasmine P. Nicodemus, Hua Li, et al. Senescence Wnt5a Suppresses Epithelial Ovarian Cancer by Promoting Cellular Updated Version

KENNEDY SPACE CENTER, FLA. - A student from Shoshone-Bannock Junior-Senior High School, Fort Hall, Idaho, holds part of a flag presented by dancers from the Shoshone-Bannock Native American community, Fort Hall, Idaho, commemorating the orbiter Columbia and her crew. The dancers performed a healing ceremony during the memorial service held at the Space Memorial Mirror for the crew of Columbia. Feb. 1 is the one-year anniversary of the loss of the crew and orbiter Columbia in a tragic accident as the ship returned to Earth following mission STS-107. Students and staff of the Shoshone-Bannock Nation had an experiment on board Columbia. The public was invited to the memorial service, held in the KSC Visitor Complex, which included comments by Center Director Jim Kennedy and Executive Director of Florida Space Authority Winston Scott. Scott is a former astronaut who flew on Columbia in 1997.

NASA Image and Video Library

2004-02-01

KENNEDY SPACE CENTER, FLA. - A student from Shoshone-Bannock Junior-Senior High School, Fort Hall, Idaho, holds part of a flag presented by dancers from the Shoshone-Bannock Native American community, Fort Hall, Idaho, commemorating the orbiter Columbia and her crew. The dancers performed a healing ceremony during the memorial service held at the Space Memorial Mirror for the crew of Columbia. Feb. 1 is the one-year anniversary of the loss of the crew and orbiter Columbia in a tragic accident as the ship returned to Earth following mission STS-107. Students and staff of the Shoshone-Bannock Nation had an experiment on board Columbia. The public was invited to the memorial service, held in the KSC Visitor Complex, which included comments by Center Director Jim Kennedy and Executive Director of Florida Space Authority Winston Scott. Scott is a former astronaut who flew on Columbia in 1997.

KENNEDY SPACE CENTER, FLA. - Dr. Ed Galindo speaks to the visitors at the memorial service held at the Space Memorial Mirror for the crew of Columbia. Galindo is science educator of Shoshone-Bannock High School and introduced the dancers from the Shoshone-Bannock Native American community in Fort Hall, Idaho. The dancers performed a healing ceremony during the memorial. Students and staff of the Shoshone-Bannock Nation had an experiment on board Columbia. Feb. 1 is the one-year anniversary of the loss of the crew and orbiter Columbia in a tragic accident as the ship returned to Earth following mission STS-107. The public was invited to the memorial service, held in the KSC Visitor Complex, which included comments by Center Director Jim Kennedy and Executive Director of Florida Space Authority Winston Scott. Scott is a former astronaut who flew on Columbia in 1997.

NASA Image and Video Library

2004-02-01

KENNEDY SPACE CENTER, FLA. - Dr. Ed Galindo speaks to the visitors at the memorial service held at the Space Memorial Mirror for the crew of Columbia. Galindo is science educator of Shoshone-Bannock High School and introduced the dancers from the Shoshone-Bannock Native American community in Fort Hall, Idaho. The dancers performed a healing ceremony during the memorial. Students and staff of the Shoshone-Bannock Nation had an experiment on board Columbia. Feb. 1 is the one-year anniversary of the loss of the crew and orbiter Columbia in a tragic accident as the ship returned to Earth following mission STS-107. The public was invited to the memorial service, held in the KSC Visitor Complex, which included comments by Center Director Jim Kennedy and Executive Director of Florida Space Authority Winston Scott. Scott is a former astronaut who flew on Columbia in 1997.

KENNEDY SPACE CENTER, FLA. - A member of the Shoshone-Bannock Native American community from Fort Hall, Idaho, reads a tribute to the crew of Columbia while another displays a handmade item with the STS-107 logo. Dancers from Shoshone-Bannock Junior-Senior High School performed a healing ceremony during the memorial held at the Space Memorial Mirror, in the KSC Visitor Complex. Feb. 1 is the one-year anniversary of the loss of the crew and orbiter Columbia in a tragic accident as the ship returned to Earth following mission STS-107. Students and staff of the Shoshone-Bannock Nation had an experiment on board Columbia. The public was invited to the memorial service, held in the KSC Visitor Complex, which included comments by Center Director Jim Kennedy and Executive Director of Florida Space Authority Winston Scott. Scott is a former astronaut who flew on Columbia in 1997.

NASA Image and Video Library

2004-02-01

KENNEDY SPACE CENTER, FLA. - A member of the Shoshone-Bannock Native American community from Fort Hall, Idaho, reads a tribute to the crew of Columbia while another displays a handmade item with the STS-107 logo. Dancers from Shoshone-Bannock Junior-Senior High School performed a healing ceremony during the memorial held at the Space Memorial Mirror, in the KSC Visitor Complex. Feb. 1 is the one-year anniversary of the loss of the crew and orbiter Columbia in a tragic accident as the ship returned to Earth following mission STS-107. Students and staff of the Shoshone-Bannock Nation had an experiment on board Columbia. The public was invited to the memorial service, held in the KSC Visitor Complex, which included comments by Center Director Jim Kennedy and Executive Director of Florida Space Authority Winston Scott. Scott is a former astronaut who flew on Columbia in 1997.

Effects of atorvastatin and diet interventions on atherosclerotic plaque inflammation and [18F]FDG uptake in Ldlr-/-Apob100/100 mice.

PubMed

Hellberg, Sanna; Sippola, Suvi; Liljenbäck, Heidi; Virta, Jenni; Silvola, Johanna M U; Ståhle, Mia; Savisto, Nina; Metso, Jari; Jauhiainen, Matti; Saukko, Pekka; Ylä-Herttuala, Seppo; Nuutila, Pirjo; Knuuti, Juhani; Roivainen, Anne; Saraste, Antti

2017-08-01

Uptake of the positron emission tomography (PET) tracer 2-deoxy-2-[ 18 F]-fluoro-d- glucose ([ 18 F]FDG) into macrophages is a sensitive marker of inflammation in atherosclerosis. To assess the anti-inflammatory effects of statins, we studied whether atorvastatin therapy reduces aortic [ 18 F]FDG uptake in hypercholesterolemic mice deficient in low-density lipoprotein receptor (Ldlr), and expressing only apolipoprotein B-100 (Ldlr -/- Apob 100/100 ). Thirty-six Ldlr -/- Apob 100/100 mice were fed a high-fat diet (HFD) for 12 weeks and then allocated to receive a HFD (n = 13), chow diet (Chow, n = 12), or HFD with added atorvastatin (HFD + A, n = 11), for another 12 weeks. In addition to aortic histopathology, [ 18 F]FDG uptake was studied in vivo using PET/computed tomography (CT), and ex vivo by gamma counting of excised aorta. Total cholesterol levels were lower in the Chow and HFD + A groups than in the HFD group (10 ± 3.2, 23 ± 4.9 and 34 ± 9.2 mmol/l, respectively), with the Chow group also showing a lower plaque burden and lower numbers of macrophages in the lesions. Compared to the HFD group, [ 18 F]FDG uptake in the aorta (normalized for blood) was lower in the Chow group in both in vivo (2.1 ± 0.21 vs. 1.7 ± 0.25, p = 0.018) and ex vivo (5.2 ± 2.3 vs. 2.8 ± 0.87, p = 0.011) analyses, whereas atorvastatin had no effect on uptake (2.1 ± 0.42 in vivo and 3.9 ± 1.8 ex vivo). [ 18 F]FDG uptake correlated with plasma total cholesterol levels. Atorvastatin therapy did not show cholesterol-independent effects on inflammation in atherosclerotic lesions in Ldlr -/- Apob 100/100 mice, as determined by histology and [ 18 F]FDG PET, whereas a cholesterol-lowering diet intervention was effective. Copyright © 2017 Elsevier B.V. All rights reserved.

The role of T1r3 and Trpm5 in carbohydrate-induced obesity in mice

PubMed Central

Glendinning, John I.; Gillman, Jennifer; Zamer, Haley; Margolskee, Robert F.; Sclafani, Anthony

2012-01-01

We examined the role of T1r3 and Trpm5 taste signaling proteins in carbohydrate-induced overeating and obesity. T1r3, encoded by Tas1r3, is part of the T1r2+T1r3 sugar taste receptor, while Trpm5 mediates signaling for G protein-coupled receptors in taste cells. It is known that C57BL/6 wild-type (WT) and Tas1r3 knock-out (KO) mice are attracted to the taste of Polycose (a glucose polymer), but not sucrose. In contrast, Trpm5 KO mice are not attracted to the taste of sucrose or Polycose. In Experiment 1, we maintained the WT, Tas1r3 KO and Trpm5 KO mice on one of three diets for 38 days: lab chow plus water (Control diet); chow, water and 34% Polycose solution (Polycose diet); or chow, water and 34% sucrose solution (Sucrose diet). The WT and Tas1r3 KO mice overconsumed the Polycose diet and became obese. The WT and Tas1r3 KO mice also overconsumed the Sucrose diet, but only the WT mice became obese. The Trpm5 KO mice, in contrast, showed little or no overeating on the Sucrose and Polycose diets, and gained slightly or significantly less weight than WT mice on these diets. In Experiment 2, we asked whether the Tas1r3 KO mice exhibited impaired weight gain on the Sucrose diet because it was insipid. To test this hypothesis, we maintained the WT and Tas1r3 KO mice on one of two diets for 38 days: chow, water and a dilute (1%) but highly palatable Intralipid emulsion (Control diet); or chow, water and a 34% sucrose + 1% Intralipid solution (Suc+IL diet). The WT and Tas1r3 KO mice both gained weight and became obese on the Suc+IL diet. Our results suggest that nutritive solutions must be highly palatable to cause carbohydrate-induced obesity in mice, and that palatability produces this effect in part by enhancing nutrient utilization. PMID:22683548

A diet high in fat and sugar reverses anxiety-like behaviour induced by limited nesting in male rats: Impacts on hippocampal markers.

PubMed

Maniam, Jayanthi; Antoniadis, Christopher P; Le, Vivian; Morris, Margaret J

2016-06-01

Stress exposure during early development is known to produce long-term mental health deficits. Stress promotes poor lifestyle choices such as poor diet. Early life adversity and diets high in fat and sugar (HFHS) are known to affect anxiety and memory. However additive effects of HFHS and stress during early development are less explored. Here, we examined whether early life stress (ELS) simulated by limited nesting (LN) induces anxiety-like behaviour and cognitive deficits that are modulated by HFHS diet. We examined key hippocampal markers involved in anxiety and cognition, testing the hypothesis that post-weaning HFHS following ELS would ameliorate anxiety-like behaviour but worsen memory and associated hippocampal changes. Sprague-Dawley rats were exposed to LN, postnatal days 2-9, and at weaning, male siblings were given unlimited access to chow or HFHS resulting in (Con-Chow, Con-HFHS, LN-Chow, LN-HFHS, n=11-15/group). Anxiety-like behaviour was assessed by Elevated Plus Maze (EPM) at 10 weeks and spatial and object recognition tested at 11 weeks of age. Rats were culled at 13 weeks. Hippocampal mRNA expression was measured using TaqMan(®) Array Micro Fluidic cards (Life Technologies). As expected HFHS diet increased body weight; LN and control rats had similar weights at 13 weeks, energy intake was also similar across groups. LN-Chow rats showed increased anxiety-like behaviour relative to control rats, but this was reversed by HFHS diet. Spatial and object recognition memory were unaltered by LN exposure or consumption of HFHS diet. Hippocampal glucocorticoid receptor (GR) protein was not affected by LN exposure in chow rats, but was increased by 45% in HFHS rats relative to controls. Hippocampal genes involved in plasticity and mood regulation, GSKα and GSKβ were affected, with reductions in GSKβ under both diet conditions, and reduced GSKα only in LN-HFHS versus Con-HFHS. Interestingly, HFHS diet and LN exposure independently reduced expression of

Persistent Diet-Induced Obesity in Male C57BL/6 Mice Resulting from Temporary Obesigenic Diets

PubMed Central

Guo, Juen; Jou, William; Gavrilova, Oksana; Hall, Kevin D.

2009-01-01

Background Does diet-induced obesity persist after an obesigenic diet is removed? We investigated this question by providing male C57BL/6 mice with free access to two different obesigenic diets followed by a switch to chow to determine if obesity was reversible. Methodology/Principal Findings Male C57BL/6 mice were randomly assigned to five weight-matched groups: 1) C group that continuously received a chow diet; 2) HF group on a 60% high fat diet; 3) EN group on the high fat diet plus liquid Ensure®; 4) HF-C group switched from high fat to chow after 7 weeks; 5) EN-C group switched from high fat plus Ensure® to chow after 7 weeks. All food intake was ad libitum. Body weight was increased after 7 weeks on both obesigenic diets (44.6±0.65, 39.8±0.63, and 28.6±0.63 g for EN, HF, and C groups, respectively) and resulted in elevated concentrations of serum insulin, glucose, and leptin and lower serum triglycerides. Development of obesity in HF and EN mice was caused by increased energy intake and a relative decrease of average energy output along with decreased ambulatory activity. After the switch to chow, the HF-C and EN-C groups lost weight but subsequently maintained a state of persistent obesity in comparison to the C group (34.8±1.2, 34.1±1.2 vs. 30.8±0.8 g respectively; P<0.05) with a 40–50% increase of body fat. All serum hormones and metabolites returned to control levels with the exception of a trend for increased leptin. The HF-C and EN-C groups had an average energy output in line with the C group and the persistent obesity was maintained despite a non-significant increase of energy intake of less than 1 kcal/d at the end of the study. Conclusion Our results illustrate the importance of considering the history of energy imbalance in determining body weight and that a persistent elevation of body weight after removal of obesigenic diets can result from very small increases of energy intake. PMID:19401758