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1

[Unusual cause of Staphylococcus aureus septicemia in a 79-year-old male patient].  

PubMed

High grade fever in the context of Staphylococcus aureus bacteremia led to hospital admission of a 79 year old male patient. A covered perforation of the ascending aorta resulted in the formation of a pseudoaneurysm which was complicated by superinfection caused by hematogenic spread of Staphylococcus aureus. The infected pseudoaneurysm found per continuitatem contact to the pericardium and resulted in bacterial pericarditis. Antibiotic pretreatment was followed by operation with a complex procedure including resection of pseudoaneurysm and suture closure of the perforation site. PMID:20521017

Sigusch, H H; Zimmermann, B; Lessig, F; Thalwitzer, J; Franke, U F W

2010-10-01

2

Low-tech rehabilitation and management of a 64 year old male patient with acute idiopathic onset of costochondritis  

Microsoft Academic Search

Objective: This study was conducted to discuss the treatment and management of a patient presenting with acute idiopathic costochondritis. Case: 64 year old male patient presenting with acute anterior chest pain of one week duration. Treatment: High-velocity low-amplitude thrust manipulation was used to the zygapophyseal joints of the thoracic spine, costotransverse, and costochondral joints involved. Acupuncture, ischemic compression, cross fibre

Karen Hudes

2008-01-01

3

Low-tech rehabilitation and management of a 64 year old male patient with acute idiopathic onset of costochondritis  

PubMed Central

Objective This study was conducted to discuss the treatment and management of a patient presenting with acute idiopathic costochondritis. Case 64 year old male patient presenting with acute anterior chest pain of one week duration. Treatment High-velocity low-amplitude thrust manipulation was used to the zygapophyseal joints of the thoracic spine, costotransverse, and costochondral joints involved. Acupuncture, ischemic compression, cross fibre friction massage techniques, and cryotherapy were utilized on the local area of pain. Specific exercise prescription (low tech rehabilitation) was also utilized. Improvement of pain reported on the Visual Analog Scale was noted with a complete resolution of the condition at the conclusion of treatment. No recurrences were reported on an eleven month follow up of the patient. Conclusion Conservative management, including manipulation and exercise prescription, may be beneficial in the treatment of benign costochondritis.

Hudes, Karen

2008-01-01

4

A 68-year-old phenotypically male patient with 21-hydroxylase deficiency and concomitant adrenocortical neoplasm producing testosterone and cortisol.  

PubMed

The steroidogenic enzyme 21-hydroxylase is necessary for the synthesis of both glucocorticoids and mineralocorticoids. 21-hydroxylase is a cytochrome P-450 enzyme and is encoded by the gene CYP21A2. Here we report a 68-year-old phenotypically 'male' but genetically female patient with 21-hydroxylase deficiency (21OHD) and the concomitant virilizing adrenocortical carcinoma. This patient grew up as a male and has not encountered any episodes of adrenal insufficiency without glucocorticoid replacement in his lifetime. A chromosome test at admission, however, identified the 46, XX karyotype, and serum 17-hydroxyprogesterone and urine pregnanetriolone and 11?-hydroxyandrostendione were all elevated, consistent with 21OHD. Moreover, serum testosterone was 1.90 ng/ml, much higher than the female standard levels, and serum cortisol was 5.7 µg/ml, slightly lower than standard levels. Genetic analysis identified the patient as a heterozygote of the two pathogenic mutations in the CYP21A2 gene: IVS2-13C(A)>G and R356W. Magnetic resonance imaging (MRI) revealed the presence of left adrenal tumor measuring 6 cm, which was subsequently diagnosed as adrenocortical carcinoma based on the criteria of Weiss. Immunohistochemical analysis of the tumor specimens revealed the expression of various enzymes involved in testosterone production, including 3?-hydroxysteroid dehydrogenase, 17?-hydroxylase/17,20-lyase, and 17?-hydroxysteroid dehydrogenase. Importantly, the expression of immunoreactive 21-hydroxylase was detected in these tumor cells. The levels of adrenal tumor-derived steroid metabolites were all markedly decreased following the surgery. This is the first report on a virilized 21OHD patient associated with the adrenocortical tumor that produces testosterone. Moreover, the concomitant adrenocortical tumor may ameliorate adrenocortical insufficiency by producing cortisol. PMID:24077358

Hayashi, Masayuki; Kataoka, Yuko; Sugimura, Yoshihisa; Kato, Fumiko; Fukami, Maki; Ogata, Tsutomu; Homma, Keiko; Hasegawa, Tomonobu; Oiso, Yutaka; Sasano, Hironobu; Tanaka, Hiroshi

2013-01-01

5

Primary paratesticular carcinoid in a 70-year-old male  

PubMed Central

Carcinoid tumors are neuroendocrine tumors and most frequently occur within tissues derived from the embryonic gut. These tumors can occur in any organ but are very rare in the paratesticular region. We hereby report a case of paratesticular carcinoid in a 70-year-old male who, to the best of our knowledge, is the oldest patient reported so far in the world literature.

Bashir, Humaira; Muanfat, Malik; Baba, Khalil Muhammad

2012-01-01

6

One-year-old male with accelerated growth and development  

PubMed Central

A 1?year?old male child with isosexual central (gonadotropin?dependent) precocious puberty caused by hypothalamic hamartoma is reported. Details of the diagnosis based solely on neuromaging characteristics, and satisfactory results of medical treatment with gonadotropin releasing hormone agonist analogues, are highlighted.

Kashyap, Ajit Singh; Anand, Kuldip Parkash; Kashyap, Surekha; Arora, Sumeet

2007-01-01

7

Gangrenous cystitis in a 42-year-old male  

PubMed Central

Gangrenous cystitis is now an extremely rare condition since the widespread use of antibiotics. The authors report a case of gangrenous cystitis in a previously fit and normal 42-year-old male who presented in acute urinary retention. He underwent a partial cystectomy during an exploratory laparotomy for clinical deterioration and peritonitis. Diagnosis of this rare disease is challenged by its low incidence and lack of characteristic pathognomic features, resulting in delayed diagnosis and increased morbidity and mortality. The authors review the literature to date on the aetiology, presentation, diagnosis and management of gangrenous cystitis and emphasise the importance of early and aggressive surgical management.

De Rosa, Antonella; Amer, Tarik; Waraich, Naseem; Bello, Alache; Parkinson, Richard

2011-01-01

8

Inflammatory cap polyposis in a 42-year-old male  

PubMed Central

INTRODUCTION Inflammatory cap polyposis (CP) is an uncommon, non-malignant condition whose pathogenesis is poorly understood. Initial presentation of CP may mimic other gastrointestinal conditions like inflammatory bowel disease, pseudomembranous colitis, irritable bowel syndrome, and colon cancer. PRESENTATION OF CASE A 42-year-old male presented with symptoms of constipation, abdominal pain and weight loss, which were suggestive of a malignancy. DISCUSSION Since the symptoms of CP resemble closely those of other gastrointestinal diseases, particularly colon cancer, making the initial diagnosis can be challenging and it is often delayed. The mainstay of initial treatment is conservative, however symptomatic and complicated cases require prompt surgical intervention with close clinical follow-up. CONCLUSION We chose to report this case because it represents a rare and unique disease process that may masquerade as a colon cancer. It is important for surgeons to be aware of this non-malignant condition since inadequate surgery usually results in recurrence.

Mason, Meredith; Faizi, Syed Adeel; Fischer, Edgar; Rajput, Ashwani

2013-01-01

9

[A 45 year-old male with lumbar tumours].  

PubMed

A 45 year old Filipino male, with history of Hepatitis B virus infection, was seen in his primary care clinic with a lumbar mass for the past three months. On physical examination the lower limbs showed decrease strength, chest X-rays showed bilateral thickening of the apical pleura, the Mantoux skin test was positive and a lumbar magnetic resonance imaging study showed a compression fracture of D4 vertebral body and soft-tissue abscess in L1. Microbiological examination was positive for M. tuberculosis complex, and with the diagnosis of Pott?s disease, he began treatment. With the advent of anti-tuberculosis drugs, spinal involvement of tuberculosis is rare, but it continues to have a high impact on morbidity. Treatment of vertebral involvement is based on anti-tuberculosis drugs and surgery. PMID:23544731

Castillo, M A; Aguilar-Shea, A L; Bernardo-Fernández, T

2012-01-01

10

Treatment of Exhibitionism in a 38YearOld Male by Hypnotically Assisted Covert Sensitization  

Microsoft Academic Search

This case study reports the successful treatment of a 38-year-old male with a 14-year history of exhibitionism. A multifaceted treatment program was used, involving hypnotically assisted covert sensitization and brief marital therapy. Hypnosis was used to develop psychic aversive and reinforcing stimuli from the patient's past experience. The value of hypnosis in enhancing imagery in cognitive treatment approaches and the

William M. Polk

1983-01-01

11

[85-years-old patient with paraneoplastic polyneuropathy].  

PubMed

Symptoms associated with neoplasms that are not a direct result of tumor growth, metastases, concomitant infection or antineoplastic treatment are known as paraneoplastic syndrome (PS). PS results from autoimmune reaction against antigens common to host nervous cells and neoplasm. The most common neurological PS are Lambert-Eaton syndrome, paraneoplastic cerebellar degeneration and polyneuropathies. The most common neoplasms inducing PS are oat cell lung carcinoma, ovarian carcinoma, breast carcinoma, neuroblastoma, thymoma and lymphoma. From 2001 to 2004 at the Dept. of Neurology, Ageing, Degenerative and Cerebrovascular Diseases the paraneoplastic polyneuropathy was diagnosed in 6 patients. The authors report on a 86-year-old male with peripheral polyneuropathy and respiratory failure who presented PS ten months prior to finding of primary neoplastic lesion in lungs. The authors discuss diagnostic and therapeutic problems in patients with PS. This report reminds that in each unclear case of polyneuropathy PS should be strongly suspected. PMID:17726875

Pieta, Ma?gorzata; Boczarska-Jedynak, Magdalena; Byrski, Mariusz; Ochud?o, Stanis?aw; Pawlas, Natalia; Opala, Grzegorz; Hartleb, Marek

2007-01-01

12

Simultaneous occurrence of herniated disc and mesothelial cyst in a 16-year-old male  

Microsoft Academic Search

The unusual, simultaneous occurrence of both a herniated disc and an intraspinal mesothelial cyst in an adolescent is reported. The patient was a 16-year-old white male who presented with sciatic pain in his left lower extremity. Myelography revealed evidence of a left L4–5 discal herniation, and a L5–S3 midline sacral lesion that proved to be a mesothelial cyst.

Nancy E. Epstein; Joseph A. Epstein; Robert Gould; Roger Hyman

1986-01-01

13

Pathology Case Study: Bladder Mass in a 73-Year-Old Male  

NSDL National Science Digital Library

This case study, from the University of Pittsburgh School of Medicine's Department of Pathology, presents information about a 73-year-old male patient. According to the patient's history, he has a "history of invasive papillary transitional cell carcinoma with excessive muscular invasion and angiolymphatic invasion." Both gross and microscopic images of the prostate, bladder, pelvic lymph nodes, and the right and left pelvic ureter are provided in this case. Using these images and the provided patient history, students can test their knowledge of pathology and compare their diagnostic findings with the official findings in the "Final Diagnosis" section.

Hakam, Ardeshir

2007-07-26

14

[Informed consent to the insertion of a PEG tube in a 53-year-old male patient with highly advanced dementia].  

PubMed

In patients with advanced dementia and dysphagia, regular fluid- and food intake together with oral medication can be guaranteed by insertion of a PEG tube. Consent to a treatment in a patient without legal capacity requires nomination of a legal substitute by an Austrian court. The following case report describes the problems associated with this particular situation exposing additional psychosocial stress to closest relatives and to the palliative care team in charge for the patient. This case report describes the legal options together with the finally chosen path of medical treatment which in clinical praxis may not always match. PMID:24158417

Roden, Christian

2014-05-01

15

Use of personalized decision analysis in decision making for Palliative vs. surgical management of the oldest-old patients with localized skin cancer in a culturally sensitive environment: a case study of a 96-year-old male Taiwanese patient.  

PubMed

Clinical management of older cancer patients is challenging, especially for those in the oldest-old age group. In the Chinese culture, the preference toward noninvasive care for patients in this age group may create a difficult situation for clinicians when the cancer is potentially curable. Palliative care may not always be the obvious choice, especially if patients suffer from quality-of-life impairment because of symptoms related to progression of the untreated cancer. Balancing between higher rates of toxicities and potential gains in quality of life from anticancer therapies among the oldest old presents a real challenge in clinical practice. Decision analysis is an analytical tool that has a long history of successful application in clinical decision making. In this case study of a 96-year-old male with localized skin cancer, we demonstrate that personalized decision analysis can be a helpful tool to assist decision making in the clinical management of cancer patients in the oldest-old age group, especially in situations in which the evidence-based literature provides little guidance. This was achieved by providing information to help the key decision makers to better understand the risk-benefit trade offs and make an informed decision. We found that the option of surgical management was associated with higher expected quality-adjusted life years (0.894) than best supportive care (0.853). Based on this finding and various scenarios explored in sensitivity analyses, the family members recommended surgery for the patient. The patient recovered well from surgery and there is no evidence of recurrence to date. PMID:22917709

Chien, Chun-Ru; Shih, Ya-Chen Tina

2013-04-01

16

Pathology Case Study: 15 Year Old Male With a Left Testicular Mass  

NSDL National Science Digital Library

This genitourinary pathology case study, provided by the University of Pittsburgh Department of Pathology, is an excellent resource for students and instructors in the health science fields. A 15-year-old male with a left testicular mass is the focus of this case. The patientâÂÂs history, gross description, and microscopic description of test results are provided to aid readers in understanding the patientâÂÂs diagnosis. The official final diagnosis is accompanied by a discussion of the contributing doctorâÂÂs findings and a list of references. This is an excellent resource for students in the health sciences to familiarize themselves with using patient history and laboratory results to diagnose patientâÂÂs conditions.

Bastacky, Sheldon; Ionescu, Diana; Molina, J. T.

2009-02-11

17

Giant cell arteritis of the thyroid in a 69-year-old male.  

PubMed

We report the case of a 69-year-old Caucasian male with a histological confirmed diagnosis of giant cell arteritis (GCA) of the thyroid. To our knowledge this is the second reported case of GCA of the thyroid with a histological confirmed diagnosis. Unique to this case is that our patient did not have the simultaneous occurrence of a positive temporal artery biopsy or classic symptoms of temporal arteritis. The patient presented with fever of unknown origin, and fatigue. Laboratory reports included a sedimentation rate of >100 mm/h and C-reactive protein level of 17.1 mg/dL. Goiter with irregular calcifications was found on the computed tomography image. Temporal artery biopsy was negative. The patient continued to have intermittent fever after discharge and was readmitted to the hospital 41 days after discharge for fever and increasing fatigue. The thyroid was resected to rule out neoplasia. Granulomatous GCA was identified within the thyroid specimen. PMID:22961124

Glassy, Crystal M; Guggenheim, Carla

2013-11-01

18

A 16-year-old male with dizziness, parasthesias, and ataxia.  

PubMed

A 16-year-old African-American male with no past medical history presented with gait instability and somnolence. He had intermittent neurological complaints during the prior 4 months, including dizziness, left arm paresthesias, decreased hearing, and inability to control his hands. After an initial diagnosis of vertigo, his symptoms progressed, leading to reevaluation and a second emergency department head computed tomography (CT) scan, which revealed a large area of hypodensity in the cerebellum. Repeat head CT on arrival to the intensive care unit showed a large, left cerebellar hemispheric stroke. This case study discusses the findings of the patient's cerebral angiogram, the diagnosis of fibromuscular dysplasia, and the aggressive treatment that likely prevented further devastating strokes in the brainstem, thalamus, and occipital lobe. This case serves as a reminder that strokes are not just an adult disease and that classic presentations can occur even in unconventional patients. PMID:24877493

Tsien, Margaret Z; Brorson, James R; Lukas, Rimas V; Dawson, Emily C

2014-05-01

19

A rare case of perforated tubular ileal duplication in 72-year-old male.  

PubMed

Enteric duplication is a rare anomaly, which is common in pediatric population, and it is very rare in adults. Enteric duplication can occur anywhere from mouth to anus. Ileal duplication is the most common (30 %) followed by duodenum, stomach, jejunum, colon and rectum. Though most cases are presented within the first 2 years of life, some may present at later age. Here we report a case of a 72-year-old male presented to us in emergency as acute abdomen, which was presumptively diagnosed as ca rectosigmoid, but later the patient developed perforative peritonitis. On exploratory laparotomy he was diagnosed as a case of perforated ileal duplication cyst. Though these lesions are very rare, the importance of enteric duplication cysts lies in the fact that they can mimic many disease conditions and may be left untreated. PMID:24426635

Ekbote, Gajanan; Pokharkar, Ashish Balwant; Moon, Prashant

2013-06-01

20

Isolated Interrupted Aortic Arch: Unexpected Diagnosis in a 63-Year-Old Male  

PubMed Central

A 63-year-old male with history of hypertension, dyspnea on exertion, and chronic chest pain was admitted for elective cardiac angiography. Arterial blood pressure was 160/90 mmHg in both arms. Femoral and popliteal pulses were extremely weak, and third (S3) and fourth (S4) heart sounds were audible. Aortography showed a mildly dilated aortic root with double brachiocephalic trunk and interruption of aortic arch at isthmus. Profuse and well-developed collaterals appeared at neck and thorax. The patient was recommended to take medical treatment for his hypertension and advanced heart failure. The aim of this paper, is to review the diagnostic and therapeutic options for treatment of the interrupted aortic arch.

Javadzadegan, Hassan; Porhomayon, Jahan; Sadighi, Alireza; Yavarikia, Mehrdad; Nader, Nader

2011-01-01

21

[Difficult diagnosis in a 17-year-old patient].  

PubMed

Medical history and clinical findings: We report on a 17-year-old boy with elevated blood glucose levels, elevated liver enzymes and obesity (BMI 32.3?kg/m2). Clinical examination showed acanthosis nigricans and a vitiligo. The rest of the physical examination was without pathological findings. Investigations: The HbA1c value was 8.6?% (71 mmol/mol), and postprandial C-peptide showed a maximum level of 1.3?nmol/l. The type 1 diabetes-associated autoantibodies against protein tyrosine phosphatase IA-2 and zinc-transporter-8 were positive, while autoantibodies to glutamic acid decarboxylase and insulin were negative. There was no ketonuria. Ultrasound showed steatohepatitis. Treatment and course: Under therapy with metformin up to 2×1?g, blood glucose levels and liver enzymes normalized after a few weeks. After two months, the HbA1c value was 6.0?% (42.1?mmol/mol), and a weight loss of 5?kg was recorded. Conclusion: In obese adolescent patients with diabetes, a clear classification right from the beginning is not always possible. Characteristic findings of type 1 and type 2 diabetes may be present simultaneously. In the presented patient, monotherapy with metformin was sufficient in the first year. Close monitoring is essential to detect the transition to insulin dependence in time. PMID:24823975

Warncke, K; Engelsberger, I

2014-05-01

22

A rare case of fibrosarcoma of the jaws in a 4-year-old male  

Microsoft Academic Search

A case of fibrosarcoma in a 4-year-old male child is reported. Primary fibrosarcomas of bone in the head and neck region are rare. The histological appearance of the tumour is related to its grade of differentiation. It could present a high level of cellularity and the amount of collagen is variable. The accepted treatment is radical surgery; however, metastases could

L Lo Muzio; M. D Mignogna; G Pannone; S Staibano; N. F Testa

1998-01-01

23

Extensive arterial calcification of unknown etiology in a 29-year-old male  

Microsoft Academic Search

Summary A 29-year-old male with generalized arterial calcification is presented. The roentgenogram showed extensive calcification bilaterally in the facial, brachial, renal, external iliac, femoral, and popliteal arteries. There was also calcification around the joints of the fingers, toes, elbows, and shoulders. The uniformity of arterial calcification in the radiograph differentiated this lesion from Mönckeberg's arteriosclerosis. The serum concentration levels of

Hideki Mori; Kohei Yamaguchi; Hideo Fukushima; Yasuhiro Oribe; Nobuo Kato; Toshiro Wakamatsu; Haruo Uzawa

1992-01-01

24

Secretory carcinoma of breast in a 17-year-old male  

PubMed Central

Background Secretory carcinoma of the male breast (juvenile carcinoma) is a rare neoplasm. Only a few cases have been reported in the literature. Case report We report here a case in a 17-year old male presenting with recurrent breast swelling. Conclusions Though considered an indolent neoplasm, secretory carcinoma does metastasise to lymph nodes and recur after local excision. Surgery in form of mastectomy with axillary clearance is the treatment of choice.

Kavalakat, Alfie J; Covilakam, Ramani K; Culas, Terence B

2004-01-01

25

A 16-year-old male with gynecomastia and ductal carcinoma in situ  

Microsoft Academic Search

While gynecomastia is common in adolescents, male breast cancer in the pediatric population is exceedingly rare. Occasional\\u000a reports describe malignant and pre-malignant lesions in mastectomy specimens for gynecomastia in young adults. We present\\u000a a 16-year-old male with unilateral gynecomastia discovered to have ductal carcinoma in situ (DCIS), treated by mastectomy\\u000a with 4 year follow-up.

Henry L. Chang; Joshua B. Kish; Barbara L. Smith; Allan M. Goldstein

2008-01-01

26

A 26-Year-Old Male with Mesothelioma Due to Asbestos Exposure  

PubMed Central

Mesothelioma is a malignancy with poor prognosis, with an average 5-year survival rate being less than 9%. This type of cancer is almost exclusively caused by exposure to asbestos. A long exposure can cause mesothelioma and so can short ones, as each exposure is cumulative. We report a case of a 26-year-old male who was exposed to asbestos during his primary school years from the age of 6 to 12. Although the tumor mainly affects older men who in their youth were occupationally exposed to asbestos, malignant mesothelioma can also occur in young adults. A medical history was carefully taken and asbestos exposure was immediately mentioned by the patient. We conducted biopsy on the right supraclavicular lymph node. The patient was not a candidate for surgery, and chemotherapy treatment was initiated. While patient's chemotherapy is still ongoing, no other similar cases of students or teachers have been traced up to date from his school. The school building was demolished in January 2009.

Zarogoulidis, P.; Orfanidis, M.; Constadinidis, T. C.; Eleutheriadou, E.; Kontakiotis, T.; Kerenidi, T.; Sakkas, L.; Courcoutsakis, N.; Zarogoulidis, K.

2011-01-01

27

Case Report: Acute Intermittent Porphyria in a 21 year-old Active Duty Male.  

PubMed

Acute Intermittent Porphyria (AIP) is one of a group of rare metabolic disorders arising from reduced activity of any of the enzymes in the heme biosynthetic pathway. The porphyrias can be very difficult for the practitioner to understand. There are several types of porphyrias, which have been known by various different names and are classified from different perspectives1 based on where the defective synthesis site is, or what the clinical manifestations are. Since practitioners rarely encounter this disease process, it is commonly not considered in the differential diagnoses. AIP can be confused with other causes of acute abdominal disorders such as appendicitis with peritonitis or nephrolithiasis. Patients with AIP typically give a history of constipation, fatigue, irritability, and insomnia that precede their acute attack. Symptoms occur intermittently in some patients with acute attacks lasting for several days or longer and were usually followed by complete recovery. This case report deals with an initial presentation of AIP in an otherwise healthy 21-year-old active duty male Soldier. Clinical presentation, diagnosis and treatment are discussed as is a brief historical anecdote. PMID:21706462

Thompson, W David

2011-01-01

28

Bilateral Pseudarthrosis of the Femoral Neck in a 25-Year-Old Male with Hereditary Hypophosphatemic Rickets  

PubMed Central

Hereditary hypophosphatemic rickets (HHR) is a rare disorder of renal phosphate wasting and the most common form of heritable rickets. Here, we report a case of an active 25-year-old male with HHR showing atraumatic bilateral femoral neck pseudarthrosis after 4 years of consecutive knee pain. A conservative therapy was administered, taking into account both the risks of surgical treatment and the little impairment even in the sport activities which the patient experienced.

Ossendorf, Christian; Vetter, Thomas; Habermann, Bjorn; Rommens, Pol M.

2014-01-01

29

Extranodal Rosai-Dorfman disease involving the right atrium in a 60-year-old male  

PubMed Central

Rosai-Dorfman disease (RDD) involving the cardiovascular system is extremely rare; to our knowledge, there are only 9 cases in the literature. Here, a case of a 60-year-old male with RDD involving the right atrium is presented. A comprehensive literature review was undertaken to summarize the clinical and pathologic features of this disorder. Virtual Slides The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/2143194139120169.

2014-01-01

30

Pathology Case Study: Osteolytic Lesion of the Tibia in a 12-Year-Old Male  

NSDL National Science Digital Library

In this case study from the Department of Pathology at the University of Pittsburgh School of Medicine, a 12-year-old male is presented with "an osteolytic lesion of the proximal left tibia." Gross and microscopic images of the bone are provided, and the diagnosis is relayed in the "Final Diagnosis" section. A discussion of the diagnosis, including the pathogenesis and morphology of the disease, is included in the final section.

Nine, Jeff S.

2007-07-25

31

Sydenham chorea in a 5-year-old Saudi patient.  

PubMed

Despite improvements in socio-economic status and the standard of health care services, rheumatic fever continuous to occur in Saudi Arabia, although with decreasing frequency. The disease is most commonly observed in school-aged children, but can also occur in a younger age group. Carditis and arthritis are the major clinical symptoms on presentation of acute rheumatic fever in young children. Rheumatic chorea is infrequently reported in young children. Here, a case of Sydenham chorea, in a 5-year-old boy, is presented. Although rare, the diagnosis of Sydenham chorea should always be considered in young children with choreiform movements. PMID:24983288

Lardhi, Amer A

2014-07-01

32

Remitting brief psychotic disorder in a 15-year-old male.  

PubMed

We present a case of remitting brief psychotic disorder in a 15 year old male, who had 4 phenomenologically alike episodes consisting of the following symptoms; sudden onset, unstructured delusions, hallucinations, clouding of consciousness, and a rapid return to his premorbid level of functioning. No evidence was found indicating a metabolic disease or a neurological disorder. The diagnostic criteria of brief psychotic disorder were fulfilled, although the clinical picture could not be described adequately by using only DSM-IV criteria. Remitting brief psychosis and the validity of different diagnostic systems are discussed. PMID:17136499

Cak, Halime Tuna; Cengel Kültür, Sadriye Ebru; Pehlivantürk, Berna

2007-06-01

33

Severe hypokalemia, metabolic alkalosis and hypertension in a 54 year old male with ectopic ACTH syndrome: a case report.  

PubMed

Ectopic ACTH syndrome is a rare cause of Cushing's syndrome accounting for about 15% of all cases. Small cell lung cancer and bronchial carcinoids account for about half of the cases. Malignant neoplasm has rapid and more aggressive metabolic effects. We report a 54-year-old male patient with phenotypic features of Cushing's syndrome with severe hypokalemia, metabolic alkalosis, hypertension and altered mental status as manifestations of an ACTH-secreting small cell carcinoma from the lung. Ectopic ACTH syndrome should be highly considered in patients with hypertension and severe hypokalemic metabolic alkalosis, especially when a lung mass is discovered. PMID:19829770

Martínez-Valles, Miguel Angel; Palafox-Cazarez, Asael; Paredes-Avina, Jose Antonio

2009-01-01

34

Cutaneous T-cell lymphoma in a 21-year-old male with Wolf-Hirschhorn syndrome.  

PubMed

We describe a case of cutaneous T-cell lymphoma occurring in a 21-year-old male with Wolf-Hirschhorn syndrome (WHS) due to a chromosome 4p16.3 deletion. This is the first documented case report of malignancy occurring in an adult with WHS. We also review the literature regarding patients with WHS and the joint occurrence of malignancy and discuss genetic changes involving chromosome 4 which may have contributed to the genesis of our patient's lymphoma. PMID:15103723

Batton, Beau; Amanullah, Adoor; Main, Charles; Fivenson, David; Jamil, Samir

2004-05-15

35

Pathology Case Study: Maxillary Cyst in a 36-Year-Old Male  

NSDL National Science Digital Library

This is a case study presented by the University of Pittsburgh Department of Pathology in which a 36-year-old man has a maxillary cyst. Visitors are given both the microscopic and gross descriptions, including images, and are given the opportunity to diagnose the patient. This is an excellent resource for students in the health sciences to familiarize themselves with using patient history and laboratory results to diagnose disease. It is also a helpful site for educators to use to introduce or test student learning in head and neck pathology.

Schubert, Eric

2007-08-07

36

Pathology Case Study: Gastric Mass in a 70-Year-Old Male with Weight Loss  

NSDL National Science Digital Library

This is a case study presented by the University of Pittsburgh Department of Pathology in which a 70-year-old man has a stomach ache, decreased appetite, and weight loss. Visitors are given both the microscopic and gross descriptions, including images, and are given the opportunity to diagnose the patient. This is an excellent resource for students in the health sciences to familiarize themselves with using patient history and laboratory results to diagnose disease. It is also a helpful site for educators to use to introduce or test student learning in gastrointestinal pathology

Richert, Charles A.; Schubert, Eric

2007-08-03

37

Pathology Case Study:A 52-Year-Old Male with "Cholelithiasis"  

NSDL National Science Digital Library

This is a gastrointestinal pathology case study presented by the University of Pittsburgh Department of Pathology in which a 52-year-old female has âÂÂcholelithiasis,â intermittant jaundice, recent pancreatitis and gallbladder polyps. Visitors are given both the microscopic and gross descriptions, including images, and are given the opportunity to diagnose the patient. This is an excellent resource for students in the health sciences to familiarize themselves with using patient history and laboratory results to diagnose. It is also a helpful site for educators to use to introduce or test student learning in gastrointestinal pathology.

Schubert, Eric

2007-12-26

38

A 52-Year-Old Male with Bilaterally Duplicated Collecting Systems with Obstructing Ureteral Stones: A Case Report  

PubMed Central

Collecting system duplication is marked by a variety of clinical syndromes. Bilateral and obstructed duplicated systems, particularly with asymmetric levels of duplication, are rare and typically due to ureteric bud development anomalies. The infrequency with which this condition exists makes it a formidable challenge for physicians and patients. To our knowledge, we present the first case report of bilateral obstruction of bilaterally duplicated collecting systems. In our case, a 52-year-old male complaining of low back pain, constipation, urinary urgency and hematuria was found to have bilateral obstructing stones as well as asymmetrical bilateral collecting system duplication. We discuss the natural history of this condition, its consequences and identification.

Scantling, Dane; Ross, Curtis; Altman, Howard

2013-01-01

39

Recurrent gastric inflammatory myofibroblastic tumour in a 13-year-old male.  

PubMed

A 13-year-old boy who had epigastric pain and pallor for 2 months and found to have an ulcerative mass in the stomach and underwent partial gastrectomy. A diagnosis of inflammatory myofibroblastic tumour (IMT) of the stomach was made on histological examination. Three years later, recurrence in the stomach, with invasion into the pancreas and hilum of the spleen was noted and was managed by wide wedge resection of the stomach, distal pancreatectomy and splenectomy. The patient has been recurrence-free for the past 2 years. Gastric IMT is an uncommon tumour in children with unpredictable prognosis. PMID:17063336

Hamidah, A; Khu, S Y; Thambidorai, C R; Muhaizan, W M; Zarina, A L; Jamal, R

2007-06-01

40

A 72-year-old patient with bilateral Maisonneuve fractures  

PubMed Central

Maisonneuve fractures result from a disruption of the medial ankle structures and a proximal fibular fracture. Patient complaints can be misleading and there is a significant rate of delayed diagnosed injuries. We present a case of bilateral Maisonneuve fractures after a fall due to a syncopal collapse. A precise clinical examination led to this rare diagnosis. The injuries were treated with syndesmotic screw fixation, removal of hardware followed after 6 weeks. The patient was asymptomatic at three-months follow up. Patients with bilateral injuries undergoing standard surgical treatment can gain full recovery, but high suspicion in clinical examination is needed to detect this uncommon bilateral injury.

Dienstknecht, Thomas; Horst, Klemens; Pape, Hans-Christoph

2012-01-01

41

Rare presentation of shock and acute mesenteric ischaemia secondary to acute adrenal insufficiency in an 11-year-old male.  

PubMed

An 11-year-old Caucasian male with history of abdominal pain, diarrhoea, fatigue, emesis and fever on the previous days presented with dehydratation, shock and acute mesenteric ischaemia. Final diagnosis of Addison's disease was made. PMID:22970910

Roldan-Martin, Maria B; Rodriguez-Ogando, Alejandro; Sanchez-Galindo, Amelia C; Parente-Hernandez, Alberto; Luengo-Herrero, Vanessa; Sanchez-Sanchez, Cesar

2013-06-01

42

Type 1 pleuropulmonary blastoma in a 3-year-old male with a cystic lung mass.  

PubMed

Pleuropulmonary blastoma (PPB) is a rare and aggressive intrathoracic malignant tumor that can be associated with cystic lung lesions in children. This neoplasm is histologically characterized by primitive blastoma and a malignant mesenchymal stroma. The authors describe a 3-year-old boy who presented with a history of fever and cough. Radiological imaging demonstrated a large cystic lesion replacing the left lower lobe. The patient underwent thoracoscopic resection of the lesion. Interestingly, the histopathology demonstrated a type 1 PPB. Type 1 lesions are usually observed in young infants, whereas older infants and children tend to present with type 2 or 3 PPB, which carry a poorer prognosis and higher risk of recurrence. Thus, the presence of large or peripherally based lung cysts should raise the suspicion of PPB. Resection is warranted for all such lesions. PMID:17101339

Al-Backer, Nouf; Puligandla, Pramod S; Su, Wendy; Anselmo, Mark; Laberge, Jean-Martin

2006-11-01

43

Transcatheter aortic valve implantation in a 54-year-old patient with aggressive HIV.  

PubMed

We report a case of a 54-year-old patient who was denied surgical replacement for severe aortic stenosis because of complicated acquired immunodeficiency syndrome and who successfully underwent transcatheter aortic valve implantation at our institution. PMID:24749120

Salizzoni, Stefano; D'Ascenzo, Fabrizio; Moretti, Claudio; Bonora, Stefano; Calcagno, Andrea; Omedè, Pierluigi; Montrucchio, Chiara; Cerrato, Enrico; Colaci, Chiara; Sheiban, Imad; Marra, Sebastiano; Rinaldi, Mauro; Gaita, Fiorenzo

2014-04-16

44

Transcatheter aortic valve implantation in a 54-year-old patient with aggressive HIV  

PubMed Central

We report a case of a 54-year-old patient who was denied surgical replacement for severe aortic stenosis because of complicated acquired immunodeficiency syndrome and who successfully underwent transcatheter aortic valve implantation at our institution.

Salizzoni, Stefano; D'Ascenzo, Fabrizio; Moretti, Claudio; Bonora, Stefano; Calcagno, Andrea; Omede, Pierluigi; Montrucchio, Chiara; Cerrato, Enrico; Colaci, Chiara; Sheiban, Imad; Marra, Sebastiano; Rinaldi, Mauro; Gaita, Fiorenzo

2014-01-01

45

Successful Remove of a Metal Axletree Causing Penile Strangulation in a 19-Year-Old Male by Degloving Operation  

PubMed Central

Penile strangulation caused by foreign bodies mostly occurs in adolescents and adult males. When it happens, foreign bodies are often not easy to be removed. Penile strangulation is a rarely described urological emergency, especially in the adolescent population. This paper demonstrates the successful removal of a metal axletree causing penile strangulation in a 19-year-old male with the help of degloving operation.

Gan, Weidong; Yang, Rong; Ji, Changwei; Lian, Huibo; Guo, Hongqian

2012-01-01

46

Case report: transient small bowel intussusception presenting as right lower quadrant pain in a 6-year-old male  

PubMed Central

In children presenting to the emergency room with right lower quadrant pain, ultrasound is the preferred initial modality. In our patient, a 6-year-old male with a sudden onset of severe right lower quadrant pain, the differential is broad, including appendicitis and intussusception. In order to narrow our differential and secure the diagnosis, our first modality was ultrasonography. With the increased use of point-of-care ultrasound in the emergency department, the diagnosis of appendicitis and ileo-colic intussusception has been made more frequently. In addition, other entities such as transient small bowel intussusception may be identified. As in our case, obstruction secondary to intussusception must be ruled out with observation, serial abdominal exams, clinical improvement, or further imaging.

2014-01-01

47

A puzzle of hemolytic anemia, iron and vitamin B12 deficiencies in a 52-year-old male.  

PubMed

A 52-year-old male with no significant past medical history reports increasing generalized fatigue and weakness for the past 2 weeks. Physical examination reveals jaundice and pallor without organomegaly or lymphadenopathy. His hemoglobin was 5.9?g/dL with a mean corpuscular volume of 87.1?fL and elevated red blood cell distribution width of 30.7%. His liver function test was normal except for elevated total bilirubin of 3.7?mg/dL. Serum LDH was 701?IU/L, and serum haptoglobin was undetectable. Further investigation revealed serum vitamin B12 of <30?pg/mL with elevated methylmalonic acid and homocysteine level. In addition, serum ferritin and transferrin saturation were low. The patient was diagnosed with hemolytic anemia secondary to vitamin B12 deficiency with concomitant iron deficiency anemia. PMID:24083040

Prueksaritanond, Suartcha; Barbaryan, Aram; Mirrakhimov, Aibek E; Liana, Palacci; Ali, Alaa M; Gilman, Alan D

2013-01-01

48

Pancytopenia in a 70-year-old african-american male: an unusual presentation of a rare disease.  

PubMed

Hairy cell leukemia is a rare lymphoid neoplasm arising from mature B-lymphocytes. Clinically, the disease presents with splenomegaly and abdominal discomfort, frequent infections, fatigue and bleeding because of related cytopenias. Bone marrow biopsy is essential for diagnosis. Below we describe a case of a 70-year-old African-American male who presented to our hematology clinic complaining of fatigue. Clinical exam and computed tomography imaging did not reveal splenic enlargement. Blood work-up revealed pancytopenia and bone marrow was diagnostic for hairy cell leukemia.The patient was started on cladribine, with gradual improvement of his symptoms and blood count abnormalities. Therefore, it is essential to keep hairy cell leukemia in the differential of pancytopenia even in the absence of a splenomegaly. PMID:24782931

Mirrakhimov, Aibek E; Ali, Alaa M; Barbaryan, Aram; Anusim, Nwabundo; Saba, Raya; Kwatra, Shawn G; Hussain, Nasir; Zdunek, Teresita; Gilman, Alan D

2014-01-01

49

Pancytopenia in a 70-Year-Old African-American Male: An Unusual Presentation of a Rare Disease  

PubMed Central

Hairy cell leukemia is a rare lymphoid neoplasm arising from mature B-lymphocytes. Clinically, the disease presents with splenomegaly and abdominal discomfort, frequent infections, fatigue and bleeding because of related cytopenias. Bone marrow biopsy is essential for diagnosis. Below we describe a case of a 70-year-old African-American male who presented to our hematology clinic complaining of fatigue. Clinical exam and computed tomography imaging did not reveal splenic enlargement. Blood work-up revealed pancytopenia and bone marrow was diagnostic for hairy cell leukemia.The patient was started on cladribine, with gradual improvement of his symptoms and blood count abnormalities. Therefore, it is essential to keep hairy cell leukemia in the differential of pancytopenia even in the absence of a splenomegaly.

Mirrakhimov, Aibek E.; Ali, Alaa M.; Anusim, Nwabundo; Kwatra, Shawn G.; Zdunek, Teresita; Gilman, Alan D.

2014-01-01

50

Renal Replacement in End-Stage Renal Disease Patients over 75 Years Old  

Microsoft Academic Search

Background: Over the last decade, the age of dialysis patients has been increasing steadily in several units in Canada. Our main objective was to assess prevalence, co-morbidity and outcome of ESRD patients over 75 years old at the beginning of dialysis treatment in our center. As a group, they were compared to younger dialysis patients treated simultaneously. Methods: In the

Isabelle Létourneau; Denis Ouimet; Marc Dumont; Vincent Pichette; Martine Leblanc

2003-01-01

51

Temperament and Child-Rearing Antecedents of Two-Year-Olds' Reactions to Male and Female Strangers.  

ERIC Educational Resources Information Center

Two-year-olds' reactions to strangers were related to ratings of their emotionality, sociability and activity and to ratings of parental love and control by both fathers and mothers. Each child received two sessions with strangers, one male and one female. Four times per session a stranger, in a friendly manner, approached each child as it sat in…

Lemly, Elizabeth Baker; Schwarz, J. Conrad

52

An Atypical Eating Disorder with Crohn's Disease in a Fifteen-Year-Old Male: A Case Study.  

ERIC Educational Resources Information Center

Discusses how 6 months after psychological intervention for an eating disorder, a 15-year-old male was diagnosed with Crohn's disease, a chronic inflammatory bowel disease. Addresses need for additional training for those from traditional school and counseling psychology programs. Advocates a team approach and consultations. (RJM)

Holaday, Margot; And Others

1994-01-01

53

Embryonal rhabdomyosarcoma of upper lid in 15-year-old patient.  

PubMed

Rhabdomyosarcoma is the most common childhood primary malignant tumor of orbit. Most of patients present between the ages of 7 and 8 years. Pure eyelid rhabdomyosarcoma is a very rare tumor with only a few reported cases in the literature. We introduce a pure embryonal rhabdomyosarcoma of upper lid in 15-year-old patient and demonstrate successful management of it. PMID:24716058

Sharifi, Mohammad

2014-01-01

54

Osteonecrosis of the knee following arthroscopic meniscectomy in patients over 50-years old  

Microsoft Academic Search

We reviewed eight patients over 50-years old, with an initial diagnosis of medial meniscal tear confirmed with magnetic resonance imaging (MRI) and with no evidence of osteonecrosis. After arthroscopic meniscectomy, all patients had recurrent aggravated knee pain and reevaluation with MRI showed images compatible with osteonecrosis. The average age was 65 years (range 54 to 75 years). The mean time

D. Luis Muscolo; Matías Costa-Paz; Arturo Makino; Miguel A. Ayerza

1996-01-01

55

Embryonal Rhabdomyosarcoma of Upper Lid in 15-Year-Old Patient  

PubMed Central

Rhabdomyosarcoma is the most common childhood primary malignant tumor of orbit. Most of patients present between the ages of 7 and 8 years. Pure eyelid rhabdomyosarcoma is a very rare tumor with only a few reported cases in the literature. We introduce a pure embryonal rhabdomyosarcoma of upper lid in 15-year-old patient and demonstrate successful management of it.

Sharifi, Mohammad

2014-01-01

56

[A 43-year-old patient with character changes, recurrent impaired consciousness and retrograde amnesia].  

PubMed

A 43-year-old male patient with recurring impaired consciousness and retrograde amnesia was admitted to the department of neurology. During the neurological evaluation no pathological findings could initially be revealed but one day the patient was confused again and presented with inadequate behavior: at this time a blood glucose value of 40 mg/dl was measured. For further evaluation the patient was transferred to our department. As the reason for the impaired consciousness was suspected to be of neuroglucopenic origin a rapid adrenocorticotropic hormone (ACTH) stimulation test was first performed to rule out adrenal insufficiency. For further evaluation a fasting test was conducted: after 48 h an episode with neuroglucopenic symptoms occurred again which disappeared after intravenous administration of glucose. The laboratory results of glucose, insulin and c-peptide determined at this point in time led to the diagnosis of an insulinoma. By ultrasound examination a hypoechogenic lesion 1.5 cm in size could be shown in the head of the pancreas and was confirmed by magnetic resonance imaging (MRI). After duodenum-preserving partial pancreatic head resection with enucleation of the insulinoma no further neuroglucopenic symptoms occurred. PMID:24429640

Mohr, A; Thiel, A; Hahnel, A; Manka, M; Agha, A; Müller, M; Schacherer, D; Girlich, C

2014-01-01

57

Endoscopic papillary balloon dilation for bile duct stone removal in patients 60 years old or younger  

Microsoft Academic Search

Background  The aim of this study was to evaluate short- and long-term outcomes in relatively young patients (?60 years old) who underwent\\u000a endoscopic papillary balloon dilation (EPBD) for bile duct stone removal.\\u000a \\u000a \\u000a \\u000a \\u000a Methods  Immediate and long-term outcomes were evaluated in 311 patients who were 60 years old or younger at the time of EPBD. The\\u000a stone recurrence rate was compared among four groups stratified

Takeshi Tsujino; Haruhiko Yoshida; Hiroyuki Isayama; Yukiko Ito; Yoko Yashima; Hiroshi Yagioka; Hirofumi Kogure; Takashi Sasaki; Toshihiko Arizumi; Osamu Togawa; Saburo Matsubara; Yousuke Nakai; Naoki Sasahira; Kenji Hirano; Minoru Tada; Takao Kawabe; Masao Omata; Kazuhiko Koike

2010-01-01

58

Successful use of eculizumab in an 86-year-old patient with paroxysmal nocturnal hemoglobinuria in Japan.  

PubMed

Eculizumab was used to treat an 86-year-old male patient with paroxysmal nocturnal hemoglobinuria, the oldest reported case in Japan. As observed in younger patients, this drug rapidly suppressed hemolysis in the present patient, which allowed weaning from blood transfusion. Eculizumab treatment has been continued for 2 years and resulted in the alleviation of renal dysfunction. Despite the patient's advanced age, the inhibition of complement activity caused by this drug did not result in infection, indicating that it is safe to use in elderly patients. PMID:24455465

Ooe, Yokiko; Nagai, Tomoko

2014-01-01

59

Four-Year-Olds' Beliefs about How Others Regard Males and Females  

ERIC Educational Resources Information Center

Children's awareness of how others evaluate their gender could influence their behaviours and well-being, yet little is known about when this awareness develops and what influences its emergence. The current study investigated culturally diverse 4-year-olds' ("N" = 240) public regard for gender groups and whether exposure to…

Halim, May Ling; Ruble, Diane N.; Tamis-LeMonda, Catherine S.

2013-01-01

60

Massive Intra-Abdominal Imatinib-Resistant Gastrointestinal Stromal Tumor in a 21-Year-Old Male  

PubMed Central

Gastrointestinal stromal tumors (GISTs) in adolescence are far less common than adult GISTs and have varied GIST genotypes that present diagnostic and therapeutic challenges. Here, we discuss a 21-year-old male with diagnosis of unresectable, imatinib-resistant GIST. At initial evaluation, a neoadjuvant treatment approach was recommended. As such, the patient received imatinib over the course of one year. Unfortunately, the GIST increased in size, and a subsequent attempt at surgical resection was aborted fearing infiltration of major vascular structures. The patient was then referred to our institution, at which time imatinib therapy was discontinued. Surgical intervention was again considered and the patient underwent successful resection of massive intra-abdominal GIST with total gastrectomy and Roux-en-Y esophagojejunostomy. Since pediatric GISTs are typically resistant to imatinib, we performed genotype analysis of the operative specimen that revealed KIT mutations associated with imatinib sensitivity and resistance. Given the sequencing data and operative findings, the patient was started postoperatively on sunitinib. This case illustrates the importance of understanding both adult and pediatric GISTs when implementing appropriate treatment regimens. Since the genotype of GISTs dictates phenotypic behavior, mutational analysis is an important component of care especially for adolescents whose disease may mirror the pediatric or adult population.

Arrington, Amanda K.; Luu, Carrie; Schoellhammer, Hans F.; Ko, Michelle; D'Apuzzo, Massimo; Park, Jinha; Kim, Joseph

2013-01-01

61

Massive intra-abdominal imatinib-resistant gastrointestinal stromal tumor in a 21-year-old male.  

PubMed

Gastrointestinal stromal tumors (GISTs) in adolescence are far less common than adult GISTs and have varied GIST genotypes that present diagnostic and therapeutic challenges. Here, we discuss a 21-year-old male with diagnosis of unresectable, imatinib-resistant GIST. At initial evaluation, a neoadjuvant treatment approach was recommended. As such, the patient received imatinib over the course of one year. Unfortunately, the GIST increased in size, and a subsequent attempt at surgical resection was aborted fearing infiltration of major vascular structures. The patient was then referred to our institution, at which time imatinib therapy was discontinued. Surgical intervention was again considered and the patient underwent successful resection of massive intra-abdominal GIST with total gastrectomy and Roux-en-Y esophagojejunostomy. Since pediatric GISTs are typically resistant to imatinib, we performed genotype analysis of the operative specimen that revealed KIT mutations associated with imatinib sensitivity and resistance. Given the sequencing data and operative findings, the patient was started postoperatively on sunitinib. This case illustrates the importance of understanding both adult and pediatric GISTs when implementing appropriate treatment regimens. Since the genotype of GISTs dictates phenotypic behavior, mutational analysis is an important component of care especially for adolescents whose disease may mirror the pediatric or adult population. PMID:23983708

Falor, Ann; Arrington, Amanda K; Luu, Carrie; Schoellhammer, Hans F; Ko, Michelle; Chow, Warren; D'Apuzzo, Massimo; Park, Jinha; Kim, Joseph

2013-01-01

62

Myocardial damage after spider bite (Latrodectus tredecimguttatus) in a 16-year-old patient.  

PubMed

The case of a 16-year-old patient with L. tredecimguttatus poisoning complicated by myocardial damage is reported. Symptoms (typical chest pain), electrocardiographic (ST-T changes in precordial leads) and echocardiographic (akinesia of interventricular septum with depressed left ventricular function) features and laboratory findings (increased myocardial enzymes) are described. PMID:9834868

Pulignano, G; Del Sindaco, D; Giovannini, M; Zeisa, P; Faia, M; Soccorsi, M; Minardi, G

1998-10-01

63

Primary alveolar rhabdomyosarcoma of the breast in a 16-year-old female patient  

Microsoft Academic Search

An extremely rare case of an alveolar rhabdomyosarcoma in the breast of a 16-year-old girl is presented. The main difficulty was the diagnosis before surgery. Strong positive reaction to desmin in immunohistochemical examinations was helpful in the histopathological diagnosis. Despite an unfavourable prognosis in this type of rhabdomyosarcoma, the patient has been free of disease since surgery and adjuvant chemotherapy,

S. Grodecka-Gazdecka; C. Ramlau; R. M. Krenz; V. Filas; J. Br?borowicz

1998-01-01

64

Neurodegeneration with Brain Iron Accumulation in an Eleven-Year-Old Jamaican Male  

PubMed Central

We present a case of an eleven-year-old boy presenting with progressive extrapyramidal signs and dementia. His imaging findings demonstrated the classic eye-of-the-tiger sign on T2W magnetic resonance imaging. He was diagnosed with pantothenate kinase-associated neurodegeneration (PKAN). This is a rare autosomal recessive inborn error of coenzyme A metabolism, caused by mutations in PANK2. This is the first reported case of PKAN from the Caribbean.

Johnson, Peter; Melbourne-Chambers, Roxanne; Desai, Nilesh; Greenaway, Emma

2014-01-01

65

Case report of a heart transplantation in a 16-year-old male  

Microsoft Academic Search

We examined ultrastructural changes and did immunohistochemical studies of atrial natriuretic peptide (ANP) in biopsied samples\\u000a obtained from the heart of a 16-year-old Japanese boy with dilated cardiomyopathy and from the transplanted donor heart. In\\u000a the right ventricle of the diseased heart, a small number of atrial granules containing ANP were found in the perinuclear\\u000a area of the cardiomyocytes and

Hiroshi Suzuki; Shigeo Hasegawa; Fumihiro Tanno; Kazuhide Akiyama; Syuji Hosoda; Katsumi Asanuma; Youichi Takeyama; Takashi Katagiri

1995-01-01

66

Acute renal failure in patients over 80 years old: 25-years' experience  

Microsoft Academic Search

Objective: To determine the epidemiological trends, spectrum of etiologies, morbidity and mortality of acute renal failure (ARF) in\\u000a patients over 80 years old.?Design: Historical cohort analysis.?Setting: Intensive care unit (ICU) of nephrology, Tenon Hospital, Paris.?Patients and participants: The criteria of inclusion was ARF, defined on the basis of a creatinine value over 120 ?mol\\/l, in patients over 80 years\\u000a of

K. Akposso; A. Hertig; R. Couprie; A. Flahaut; C. Alberti; G.-A. Karras; J.-P. Haymann; M.-A. Costa De Beauregard; A. Lahlou; E. Rondeau; J.-D. Sraer

2000-01-01

67

Tongue cancer in young patients: case report of a 26-year-old patient  

PubMed Central

Introduction This article presents the case of a 26-year-old woman with tongue cancer. The median age at the diagnosis of the tongue’s cancer is 61?years. Only approximately 2% of patients are diagnosed before the age of 35. Case presentation Our patient survived acute myeloid leukemia (AML) before her second year. She had been having recurrent, poorly healing aphtae on the right side of the tongue for a period of months before the symptoms of the tongue cancer appeared. As a treatment a partial glossectomy was conducted on the right side and a neck dissection of levels I-III. Than a reconstruction of the tongue with a radialis free vascularised flap from left side was performed. Discussion It should be always looked for the causal factor in young patients with a neoplasm. There is strong evidence for second malignant neoplasms in survivors of childhood cancer.

2012-01-01

68

A Case of Idiopathic Central Serous Chorioretinopathy in a 12-year-old Male Treated with Bevacizumab  

PubMed Central

A 12-year-old male presented with a chief complaint of a 1-month-history of decreased visual acuity in his right eye. The patient had no past history of steroid use or other systemic diseases. On fundus examination, which included fluorescent angiography (FAG) and optical coherence tomography (OCT), the patient was diagnosed with idiopathic central chorioretinopathy, whose clinical course was monitored without any specific treatments. At the time of admission, the best-corrected visual acuity was 0.5 in the right eye and 1.0 in the left eye. On fundoscopy, a serous detachment of 1 disc diameter in size was observed in the posterior pole. According to the FAG and the OCT, serous neurosensory detachment was present. After two months of monitoring the clinical course, the best corrected visual acuity in the right eye was 0.8, and there was improvement of neurosensory retinal detachment. However, OCT detected recurrence after five months, and the corrected visual acuity was decreased to 0.6. Bevacizumab was then injected into the vitreous cavity. Complete resolution of the subretinal fluid resulted eight months later, and the corrected visual acuity improved to 1.0.

Kim, Yu Cheol; Kim, Si Dong

2012-01-01

69

Conservative management of a 31 year old male with left sided low back and leg pain: a case report  

PubMed Central

Objective: This case study reported the conservative management of a patient presenting with left sided low back and leg pain diagnosed as a left sided L5-S1 disc prolapse/herniation. Clinical features: A 31-year-old male recreational worker presented with left sided low back and leg pain for the previous 3–4 months that was exacerbated by prolonged sitting. Intervention and Outcome: The plan of management included interferential current, soft tissue trigger point and myofascial therapy, lateral recumbent manual low velocity, low amplitude traction mobilizations and pelvic blocking as necessary. Home care included heat, icing, neural mobilizations, repeated extension exercises, stretching, core muscle strengthening, as well as the avoidance of prolonged sitting and using a low back support in his work chair. The patient responded well after the first visit and his leg and back pain were almost completely resolved by the third visit. Summary: Conservative chiropractic care appears to reduce pain and improve mobility in this case of a L5-S1 disc herniation. Active rehabilitative treatment strategies are recommended before surgical referral.

Howell, Emily R.

2012-01-01

70

[Outpatient treatment of selective mutism: long-standing selective mutism in a 17-year-old male].  

PubMed

The present case report describes the successful treatment of a 17 year old male adolescent suffering for 10 years from selective mutism. Following a summary review of recent publications on therapy approaches, the report describes the treatment concept in the present case, including detailed assessment of co-morbid disorders, motivation for change, behaviour therapy with supporting drug intervention, and intensive co-operation with parents and other caretakers. PMID:20047174

Herdener-Pinnekamp, Katharina; Gundelfinger, Ronnie; Steinhausen, Hans-Christoph

2010-01-01

71

Liver transplantation in a 23-year-old tyrosinaemia patient: Effects on the renal tubular dysfunction  

Microsoft Academic Search

Orthotopic liver transplantation was performed on a 23-year-old female with hereditary tyrosinaemia. The disorder was diagnosed\\u000a at 7 years of age due to severe rickets, and the patient was treated with a diet restricted in phenylalanine and tyrosine.\\u000a Nineteen months before the transplantation she had an acute episode of diffuse gastrointestinal bleeding due to portal hypertension.\\u000a Three subsequent bleeding episodes

E. A. Kvittingen; E. Jellum; O. Stokke; A. Flatmark; A. Bergan; G. Sødal; S. Halvorsen; E. Schrumpf; E. Gjone

1986-01-01

72

Acute-onset choreiform movements in a previously healthy 4-year-old patient.  

PubMed

We report the case of 4-year-old male with sinus venous thrombosis leading to bilateral thalamic and basal ganglia strokes presenting as generalized choreiform movements. Acute-onset chorea in the pediatric population is most commonly associated with Sydenham chorea, which is a manifestation of acute rheumatic fever. Chorea is a much less commonly noted sign of stroke, and when it occurs, it typically presents as hemichorea. Given the unlikely presentation, rapid and appropriate imaging was the key to diagnosis. PMID:24378857

Cohen, Gordon J; Tekes, Aylin; Ngo, Thuy L

2014-01-01

73

Diffuse malignant peritoneal mesothelioma in a 31-year-old patient--case report.  

PubMed

This is a case report of a diffuse malignant peritoneal mesothelioma in a 31-year-old woman. The patient presented with pains in the small pelvis followed by abdominal distension. By pelvic ultrasonography a tumorous mass of cystic architecture was verified in the small pelvis. She was submitted to laparoscopy. The diagnosis of the disease was established by histopathological examination of the material sample taken during laparoscopy. The patient was subsequently submitted to laparotomy upon which peritonectomy, omentectomy and appendectomy were performed. Postoperative combined chemotherapy was given. The patient has been well since completion of the treatment. PMID:17479682

Prorocic, M; Vasiljevic, M; Jankovic, S; Dzatic, O

2007-01-01

74

Primary synovial chondrosarcoma of the hip joint in a 45-year-old male: case report and literature review.  

PubMed

Synovial chondrosarcoma is a rare tumor, seen most commonly arising from antecedent synovial chondromatosis, the more common benign entity. The distinction between the two can be difficult on the basis of clinical, imaging, and histologic criteria. The authors report a case of pathologically proven synovial chondrosarcoma of the hip in a 45-year-old male initially treated for presumed synovial chondromatosis. The case is made more unusual by the fact that no evidence of co-existent synovial chondromatosis was noted at histology. The literature as regards synovial chondrosarcoma, both de novo and secondary cases, is reviewed. PMID:21562938

Rybak, Leon David; Khaldi, Lubna; Wittig, James; Steiner, German C

2011-10-01

75

Human papillomavirus vaccine uptake among 9-17 year old males in the United States  

PubMed Central

In 2009, a quadrivalent HPV vaccine was approved and “permissively” recommended for US males aged 9 to 26 y to protect against genital warts. The purpose of this study was to examine parental awareness and HPV vaccine uptake among 9–17 y old males during the first year following this recommendation. Data from the 2010 National Health Interview Survey (NHIS) were obtained to assess vaccination status (n = 2973) of this age group. Univariate logistic regression analysis was performed to examine correlates of parental awareness and uptake of the HPV vaccine. Overall, 55% of parents with sons were aware of the HPV vaccine. The likelihood of parental awareness was lower among minorities and adolescents with low family incomes, and higher among adolescents with insurance, higher parental education, and those who had a well-child check up and dental examination in the past year than their counterparts. Only 2.0% and 0.5% of 9–17 y old males initiated (? 1 dose) and completed (? 3 doses) the vaccine series, respectively. Adolescents with a Hispanic origin (odds ratio (OR) 2.03, 95% confidence interval (CI) 1.09–3.78), low family income (OR 2.89, 95% CI 1.48 -5.57), and history of influenza vaccination in the past year (OR 1.89, 95% CI 1.11 -3.22) were more likely than their counterparts to initiate the HPV vaccine. On the other hand, adolescents with private insurance (OR 0.44, 95% CI 0.20 -0.94) and those who had college educated parents (OR 0.45, 95% CI 0.22 -0.89) were less likely to initiate the vaccine. This study showed that very few adolescent males received any doses of HPV vaccine during the first year following its recommendation for this gender. Thus, interventional programs are needed to improve vaccine uptake among adolescent males.

Laz, Tabassum H.; Rahman, Mahbubur; Berenson, Abbey B.

2013-01-01

76

Echocardiographic features of cardiac amyloidosis presenting as endomyocardial disease in a 54-year-old male.  

PubMed

Although primary cardiac amyloidosis is a rare affliction of the heart, its clinical and pathology features have been well described. Patients generally present with exertional dyspnea, chest discomfort, or congestive heart failure. Cardiac imaging typically reveals ventricular wall thickening, systolic and diastolic dysfunction, valvular thickening, and pericardial effusion. In the case reported herein, a patient with suspected cardiac amyloid demonstrated electrocardiographic and echocardiographic findings that were not only inconsistent with typical depositional patterns, but also potentially suggestive of endomyocardial disease. PMID:19632539

Fealey, Michael E; Edwards, William D; Buadi, Francis K; Syed, Imran S; Grogan, Martha

2009-08-01

77

Chloramphenicol Toxicity Revisited: A 12-Year-Old Patient With a Brain Abscess  

PubMed Central

Chloramphenicol, a broad-spectrum antibiotic, is rarely used in the United States due to its well-described adverse effects. Because of its limited use, many clinicians are unfamiliar with its indications, spectrum of activity, and potential adverse drug effects. We describe a 12-year-old patient who presented after two craniotomies for a persistent brain abscess complicated by long-term chloramphenicol administration. Findings for this patient were consistent with many of the adverse drug effects associated with chloramphenicol, including elevated chloramphenicol serum concentrations, anemia, thrombocytopenia, reticulocytopenia, and severe metabolic acidosis. Rare manifestations of chloramphenicol toxicity that developed in this patient included neutropenia, visual field changes, and peripheral neuropathy. Chloramphenicol administration was discontinued, and hemodialysis was initiated for severe metabolic acidosis. The patient recovered with severe visual field deficits. Although chloramphenicol is rarely indicated, it remains an effective antibiotic. Healthcare providers should become familiar with the pharmacology, toxicology, and monitoring parameters for appropriate use of this antibiotic.

Wiest, Donald B.; Cochran, Joel B.; Tecklenburg, Fred W.

2012-01-01

78

Neuroblastoma in a 55-Year-Old Patient: A Case Report  

PubMed Central

Background Neuroblastomas account for 97% of all neuroblastic tumors and for approximately 15% of all pediatric cancer fatalities. However, in adults neuroblastoma is a very rare finding. Case Report Here, we present the case of a 55-year-old patient who was diagnosed with neuroblastoma stage IV one year after the false diagnosis of a non-secretory multiple myeloma. Results The patient received six cycles of a chemotherapy protocol with cisplatin, etoposide and vindesine alternating with vincristine, dacarbazine, ifosfamide and doxorubicin, but the response to treatment was insufficient (stable disease). Conclusion The standard chemotherapy protocols used for children are not sufficient for adult patients. Different treatment approaches are needed to improve the prognosis of adult patients with neuroblastoma.

Then, Cornelia; Ebelt, Kathleen; Langer, Alexandra; Mayr, Doris; Schmidmaier, Ralf; Oduncu, Fuat

2010-01-01

79

Pathology Case Study: Intermittent Fevers in a 43-Year-Old Black Male  

NSDL National Science Digital Library

The University of Pittsburgh School of Medicine's Department of Pathology has compiled a series of case studies to help students and instructors. In this particular study the patient is complaining of intermittent fevers. The case provides test results and data as well as microscopic photos and description. Clicking on the final diagnosis provides a thorough explanation of the diagnosis as well as treatment.

Dorvault, Christine; Richert, Charles A.

2007-08-12

80

Developmental Venous Anomaly with Contralateral Impaired Venous Drainage in a 17-Year-Old Male  

PubMed Central

Summary Developmental venous anomalies (DVA) drain normal neural tissue and are mostly discovered incidentally. We describe a young patient with a left hemisphere superficial to deep DVA and right hemisphere venous outflow restriction presenting with a seizure. The right hemisphere drainage variation is not typical of a DVA but represents another drainage pattern on the border of normality.

Enslin, Jmn; Lefeuvre, D; Taylor, A

2013-01-01

81

Noninvasive assessment of cardiomyopathy in normotensive diabetic patients between 20 and 50 years old  

SciTech Connect

To further the understanding of diabetic heart disease, we tested the hypothesis that an asymptomatic group of normotensive diabetic patients between 20 and 50 years old had a restrictive cardiomyopathy independent of clinically significant coronary artery disease. Quantitative two-dimensional echocardiography and stress myocardial perfusion scintigraphy were performed to detect and characterize the cardiac abnormalities in this study group comprising 88 patients with rigorously classified diabetes and 65 volunteer control subjects. Diabetic patients were shown to have a mildly reduced left ventricular end-diastolic volume index: 50.1 +/- 8.2 and 52.1 +/- 14.7 mL/m2 for patients with type I and type II diabetes, respectively, versus 58.9 +/- 11.7 mL/m2 for control subjects. The left ventricular diastolic filling was also impaired in diabetic patients as reflected by a lower atrial emptying index: 0.73 +/- 0.24 and 0.76 +/- 0.3 for type I and type II diabetics, respectively, compared with 1.14 +/- 0.24 for control subjects. Exercise tolerance was normal in subjects with type I diabetes and slightly reduced in subjects with type II diabetes. Only one patient developed regional ischemia on thallium exercise testing. Using a comprehensive, noninvasive approach, we have shown that asymptomatic normotensive patients with type I or type II diabetes who were between 20 and 50 years old had a restrictive cardiomyopathy characterized by mildly reduced left ventricular end-diastolic volume and altered left ventricular compliance independent of critical coronary artery disease.

Bouchard, A.; Sanz, N.; Botvinick, E.H.; Phillips, N.; Heilbron, D.; Byrd, B.F. 3d.; Karam, J.H.; Schiller, N.B. (Univ. of California, San Francisco (USA))

1989-08-01

82

Fifteen-year-old colon cancer patient with a 10-year history of ulcerative colitis  

PubMed Central

Inflammatory bowel disease (IBD) is regarded as one of the risk factors for colorectal cancer, and early detection of cancer in these patients may be difficult, especially in pediatric patients. Prognosis of pediatric colorectal cancer is known to be poor, because of delayed diagnosis and unfavorable differentiation. We report a case of a pediatric patient with a 10-year history of ulcerative colitis who was diagnosed with sigmoid colon cancer when he was 15 years old. He underwent proctocolectomy with ileal pouch anal anastomosis. Postoperative pathological examination of the tumor revealed adenocarcinoma. The pericolic tissue layer was infiltrated, but metastases were not found in either of the two lymph nodes. Children with a long history of predisposing factors such as IBD need particular attention to the possibility of colorectal cancer. Early diagnosis through regular screening with colonoscopy is one of the most important critical factors for a good prognosis.

Noh, Seung Yeon; Oh, Seung Young; Kim, Soo-Hong; Kim, Hyun-Young; Jung, Sung-Eun; Park, Kwi-Won

2013-01-01

83

[Myocardial revascularization surgery in an 87-year-old patient. A case report].  

PubMed

A 87 years old patient, with independent life style, presented unstable angina in spite of medication. Cineangiocoronariography demonstrated severe triarterial lesions, with good distal segments and preserved left ventricular contractility. Three saphenous vein grafts were performed. Some clinical measures were employed: a) manitol, furosemide and Ringer solution were infused two hours before and during surgery; the infusion was maintaned during the two postoperative days; b) limited use of nephrotoxic agents; c) adequate doses of medication; d) red cells infusion in spite of higher hematocrit levels than those present in younger patients; e) early start of respiratory physiotherapy and deambulation. Mean arterial pressure was maintained over 80 mm/Hg during surgery. During the period of extracorporeal circulation a hollow capillary membrane oxygenador was employed. Immediate postoperative course, up till six months, was free of coronary insufficiency symptoms. This case demonstrates the benefits of myocardial revascularization in elderly patients, respecting some peculiarities of the geriatric therapeutics. PMID:2629674

Wajngarten, M; Jatene, F B; Bosisio, I B; Azul, L G; Pileggi, F J; Jatene, A D

1989-09-01

84

Synthetic cannabinoid overdose in a 20-year-old male US soldier.  

PubMed

Popularity of synthetic cannabinoids among US military service members has risen over the last several years, leading to an increase in hospitalizations and legal actions stemming from its use and possession. Although synthetic cannabinoids, collectively referred to as "Spice," are similar in structure to the active metabolites found in cannabis, significant concerns exist regarding the severity of short- and long-term medical and psychiatric sequelae. This article presents a case, in which a patient experienced severe medical and psychiatric symptoms far exceeding the severity and duration typically resulting from cannabis use. PMID:23327506

Berry-Cabán, Cristóbal S; Ee, Juliana; Ingram, Victoria; Berry, Carlos E; Kim, Eugene H

2013-01-01

85

Bladder Cancer versus Hemorrhagic Cystitis: A Case of Mistaken Identity in a 34-Year-Old Male Undergoing Therapy for Granulomatosis with Polyangiitis  

PubMed Central

A 34-year-old male was referred for management of bladder cancer noted on workup for gross hematuria and new-onset irritative voiding symptoms. The patient's history was significant for recently diagnosed granulomatosis with polyangiitis for which he was undergoing treatment with oral cyclophosphamide and corticosteroids. Cystoscopy revealed lesions suspicious for malignancy, but the patient was diagnosed with hemorrhagic cystitis secondary to BK virus infection upon cytology review, and immunostaining confirmed a polyomavirus infection of the urothelium. The patient's symptoms resolved after a modification of his immunosuppressive regimen, and antiviral therapy was ultimately unnecessary. Though symptomatic BK virus infection of the genitourinary tract is common in immunosuppressed transplant patients, its occurrence in a patient undergoing immunomodulation for an autoimmune disease has not been reported yet. This case illustrates the potential for active BK virus infections in atypical patient populations and underscores the importance of rigorous hematuria workup, particularly in patients with multiple risk factors.

Amatruda, Jonathan; Dieckhaus, Kevin; Hegde, Poornima; Taylor, John

2014-01-01

86

Successful Pregnancy in a 31-Year-Old Peritoneal Dialysis Patient with Bilateral Nephrectomy  

PubMed Central

Frequency of pregnancy among childbearing age women with end-stage renal disease (ESRD) undergoing long-term periodic dialysis ranges from 1% to 7%. Although pregnancy in dialysis women with ESRD is considered a largely high-risk pregnancy, occurrence of successful pregnancy is not impossible with success rates approaching 70%. Rates of successful pregnancy are greatly impacted by early pregnancy diagnosis and preserved residual renal functions. Herein, to the best of our knowledge, we report the first case of successful pregnancy (despite late diagnosis at 14 weeks of gestation) in a 31-year-old peritoneal dialysis patient with bilateral nephrectomy and no whatsoever preserved residual renal function. Moreover, a literature review on pregnancy in dialysis patients is presented.

Nazer, Ahmed; AlOmar, Osama; Al-Badawi, Ismail A.

2013-01-01

87

[A 46-year-old patient with atrial fibrillation, elevated thyroid hormones and normal thyrotropine].  

PubMed

We report on a 46 year old patient with a history of paroxysmal atrial fibrillation who presented to our emergency room. Diagnostic evaluation showed elevated free peripheral thyroid hormone levels and thyrotropine (TSH) hormone within normal limits. Ultrasound of the thyroid was normal, and thyroid autoantibodies were found in the normal range. There was a positive family history for thyroid dysfunction. TSH-producing adenoma (TSHoma) of the pituitary gland - the main differential diagnosis - was excluded by cranial MRI and laboratory tests. Familial thyroid hormone resistance (Refetoff syndrome) was suspected and could be confirmed by detection of a pathogenic mutation within the beta-thyroidhormone receptor gene. After spontaneous conversion to sinusrhythm the patient was treated with a beta(1)-selective betareceptor blocker. Up to now, no specific treatment is available to correct the defective beta-thyroidhormone receptor. PMID:19902155

Opherk, I V; Gutt, B; Volz, S; Siegmund, T; Schumm-Draeger, P M

2010-03-01

88

Endometrial carcinoma in a 15-year-old obese patient with persistent uterine bleeding.  

PubMed

Endometrial carcinoma is the most common malignancy of the upper female genital tract but is rare in teenagers. Here, we report the case of a 15-year-old, nulliparous, morbidly obese female with complaints of asthenia and menometrorrhagia lasting for six months. On examination, the patient had an enlarged uterus approximately 14 gestational weeks in size, and ultrasound revealed an intrauterine mass and polycystic ovaries. An endometrial biopsy performed during hysteroscopy revealed endometrioid adenocarcinoma, and magnetic resonance imaging showed myometrial invasion. The patient underwent a laparotomy involving total abdominal hysterectomy, right salpingo-oophorectomy, wedge-shape dissection of the left ovary, and pelvic and para-aortic lymphadenectomy. We analyze the pathogenesis of endometrial carcinoma in this case and discuss the risk factors for endometrial carcinoma, especially in young women. Gynecologists should be vigilant for persistent abnormal uterine bleeding and other signs of endometrial carcinoma in young women, especially those who have risk factors for the disease. PMID:24456540

Liu, Guoyan; Wang, Yingmei; Zhang, Xuhong; Yuan, Bibo; Han, Cha; Xue, Fengxia

2014-04-01

89

Iatrogenic Inflammatory Fibrosis of Hard Palate in a 13-Year-Old Female Patient  

PubMed Central

Palatal swellings are rare in children and the incidence differs from that of the adult counterparts. When the palatal swellings do arise in children, they usually are palatal abscess from periapical region, and few cases like pleomorphic adenoma in young adults have also been reported. But inflammatory fibrosis of palate in children is a rare occurrence. Inflammatory fibrosis is formation of excess fibrous connective tissue in an organ or tissue, as a reparative or reactive process. This report describes an unusual case of iatrogenic inflammatory fibrosis on the palate due to extraction of tooth number 22 in a 13-year-old female patient. The patient presented with a single large well-circumscribed oval palatal swelling that was soft, fluctuant, not fixed, and nontender. Surgical excision of the lesion was done and it was sent for histopathological assessment. The biopsy showed fibrous tissue with collagen fibers, spindle shaped fibroblasts, neovascularization, RBCs, chronic inflammatory cells, and traces of salivary gland and nerve tissue.

Reddy, G. Siva Prasad; Gurugubelli, Sri Veda

2013-01-01

90

Tongue squamous cell carcinoma as a possible distinct entity in patients under 40 years old  

PubMed Central

Much controversy exists in the published literature regarding the clinical course and prognosis of tongue squamous cell carcinoma (SCC) in young patients. The aim of the current study was to evaluate the clinical results of tongue SCC in young patients. A total of 176 patients were included in this retrospective study. The patients were divided into two groups (young and old) according to an age cut-off of 40 years. The ?2 test and Kaplan-Meier method were used to analyze the variables. In total, 15 patients were <40 years old and placed into the young group, with five-year recurrence-free survival (RFS) and disease-specific survival (DSS) rates of 30 and 63%, respectively, compared with 47 and 62%, respectively, in the old group. No significant differences were identified between the RFS and DSS rates of the two groups, however, the young patients exhibited a different failure pattern. Overall, nine out of 10 recurrences in the young group occurred at a primary site compared with 18 out of 70 in the old group (P<0.001). Univariate analysis revealed that gender and differentiation were associated with recurrence and neck nodal involvement. In addition, poor differentiation was found to significantly decrease the DSS time. However, the prognosis of tongue SCC in the young patient group did not appear to differ from that of the old patient group. Furthermore, in the young patient group, local recurrence was the most common failure pattern and tumor differentiation was the most important prognostic factor.

FANG, QI-GEN; SHI, SHUANG; LIU, FA-YU; SUN, CHANG-FU

2014-01-01

91

Successful Anesthesia and Hip Surgery in a 107-Year-Old Patient  

PubMed Central

Patient: Female, 107 Final Diagnosis: Hip fracture Symptoms: — Medication: — Clinical Procedure: Hip surgery Specialty: Orthopedics and Traumatology Objective: Rare disease Background: In modern societies, elderly populations have increased over the last four decades and have become the main clients of medical services. A hip fracture is a significant injury for anyone, but for older people it can be catastrophic. Case Report: A 107-year-old female was admitted with fracture of the right hip. The patient took a single 200 mL carbohydrate drink orally two hours before surgery. Before induction of spinal anesthesia, routine monitoring was started and an intravenous line was placed. Crystalloids and hydroxyethyl starch in 0.9% sodium chloride solution were administered intravenously during the operation. After sedation with i.v. ketamine and midazolam, spinal puncture was performed with the patient in the sitting position and isobaric bupivacaine were administered. The level of sensory block was observed in T12 and motor blockade (grade 3) of the lower limbs. The surgical procedure lasted 60 minutes without hypotension, bradycardia or decreased oxygen saturation. For safety reason, the patient was transferred to the ICU for monitoring; intravenous hydration was withdrawn and released oral feeding six hours after the end of surgery. The patient was sent to his residence on the morning of the second day. Conclusions: This case showed that with suitable techniques and conduits can perform surgery in a patient with 107 years.

Imbelloni, Luiz Eduardo; Lima, Umberto; Pedrosa, Francisco Kartney

2014-01-01

92

Chiropractic management of a 30-year-old patient with Parsonage-Turner syndrome  

PubMed Central

Objectives The purpose of this case report is to describe the chiropractic management of a patient presenting with right arm paralysis and a diagnosis of Parsonage-Turner syndrome. Clinical Features After receiving nerve entrapment release surgery, a 30-year-old man presented with a right arm contracture, atrophy, and weakness with general paralysis of the forearm and index finger of 6 weeks' duration. Intervention and Outcome The patient was provided chiropractic care that included high-velocity/low-amplitude spinal manipulation based upon applied kinesiology manual muscle testing, soft tissue trigger point therapy, exercises, and stretches. The patient demonstrated improvement in range of motion after the first treatment session. By the eighth treatment, he was able to fully straighten his arm. Three years later, the patient reported that he was able to do mountain climbing and that his arm was fully functional and pain-free. Conclusion For this patient, chiropractic care seemed to be successful in relieving his right arm paralysis and restoring normal arm movement.

Charles, Eugene

2011-01-01

93

Rhabdomyolysis and Cardiomyopathy in a 20-Year-Old Patient with CPT II Deficiency.  

PubMed

Aim. To raise the awareness of adult-onset carnitite palmitoyltransferase II deficiency (CPT II) by describing clinical, biochemical, and genetic features of the disease occurring in early adulthood. Method. Review of the case characteristics and literature review. Results. We report on a 20-year-old man presenting with dyspnea, fatigue, fever, and myoglobinuria. This was the second episode with such symptoms (the previous one being three years earlier). The symptoms occurred after intense physical work, followed by a viral infection resulting in fever treated with NSAIDs. Massive rhabdomyolysis was diagnosed, resulting in acute renal failure necessitating plasmapheresis and hemodialysis, acute hepatic lesion, and respiratory insufficiency. Additionally, our patient had cardiomyopathy with volume overload. After a detailed workup, CPT II deficiency was suspected. We did a sequencing analysis for exons 1, 3, and 4 of the CPT II gene and found that the patient was homozygote for Ser 113 Leu mutation in exon 3 of the CPT II gene. The patient recovery was complete except for the cardiomiopathy with mildly impaired systolic function. Conclusion. Whenever a patient suffers recurrent episodes of myalgia, followed by myoglobinuria due to rhabdomyolysis, we should always consider the possibility of this rare condition. The definitive diagnose of this condition is achieved by genetic testing. PMID:24563797

Vavlukis, M; Eftimov, A; Zafirovska, P; Caparovska, E; Pocesta, B; Kedev, S; Dimovski, A J

2014-01-01

94

Generalized Peritonitis Secondary to Spontaneous Perforation of Pyometra in a 63-Year-Old Patient  

PubMed Central

Spontaneous perforation of pyometra resulting in generalized diffuse peritonitis is extremely uncommon. Herein, we report the case of a 63-year-old woman who presented to emergency department with a 2-day history of severe diffuse abdominal pain, high-grade fever, nausea, and vomiting. Acute abdomen series was done, and upright plain chest radiograph showed free air under diaphragm. A noncontrast-enhanced computed tomography scan showed a significantly distended fluid-filled uterus measuring 10 × 7.8 × 10?cm, in addition to a single focus of perforation involving the uterine fundus and associated with presence of free air within the nondependant area. No evidence of ascites or pelvi-abdominal lymphadenopathy was identified. A preoperative diagnosis of generalized peritonitis secondary to spontaneous perforation of uterus was established. Subsequently, patient underwent urgent exploratory laparotomy which revealed pus-filled uterus with perforated fundus. Diagnosis of generalized peritonitis secondary to spontaneous perforation of pyometra was established. Consequently, patient underwent total abdominal hysterectomy with bilateral salpingo-oophorectomy, as well as thorough drainage and irrigation of pelvi-abdominal cavity. Postoperatively, patient was admitted to intensive care unit. Histopathological examination of uterus was negative for malignancy, and surgical culture grew Streptococcus constellatus. Patient had an uneventful recovery. Moreover, a brief literature review on pyometra is presented.

Abu-Zaid, Ahmed; AlOmar, Osama; Nazer, Ahmed; Azzam, Ayman; Abudan, Zainab; Al-Badawi, Ismail

2013-01-01

95

Congenital insensitivity to pain with anhidrosis: a case report of a 33-year-old patient.  

PubMed

Congenital insensitivity to pain with anhidrosis is a type IV hereditary sensory and autonomic neuropathy, presenting early in life. This disorder results from defective neural crest differentiation with loss of the first-order afferent system, which is responsible for sensations of pain and temperature; a neuronal loss in the sympathetic ganglia is also present. A case of a 33-year-old patient with congenital insensitivity to pain with anhidrosis is presented. From the time of birth, he did not sweat and did not respond to painful stimuli, although unexplained bouts of fever were often observed in infancy; an extensive workup during childhood helped establish the diagnosis. Throughout childhood and adulthood, the patient presented multiple infections and fractures in various sites of his body, growth disturbances, and avascular necrosis, and Charcot arthropathies and joint dislocations mainly affected his elbow and hip joint. At the final follow-up, at the age of 33 years, he was found to be obese, with a limited social life. A Charcot elbow restricted the activity of his left upper limb, and the dislocated hips combined with the instability of the ankle joints limited the ambulation distance. A specific treatment protocol has not been established in the literature; the main principles that can be applied in patients with normal intelligence include training programs to prevent self-mutilation and accidental injuries and an early diagnosis and treatment of the infections. PMID:22422007

Kosmidis, Ilias; Krallis, Panagiotis; Tsiamasfirou, Damiani; Filiopoulos, Konstantinos

2013-01-01

96

Alumina-on-Alumina Hip Arthroplasty in Patients Younger Than 30 Years Old  

PubMed Central

THA in patients younger than 30 years old presents challenges: the initial technical challenge relates to the initial disease that often causes deformities making reconstruction difficult, while the long-term challenge is wear and subsequent osteolysis and component loosening. Ceramic-on-ceramic prostheses may represent a valuable option to reduce wear. We retrospectively studied 101 patients (132 hips) with ceramic-on-ceramic prostheses implanted from 1977 to 2004. As a result of the long span of time, different implant designs and modes of fixation were used. The average age of the patients was 23.4 ± 5 years (range, 13–30 years), and the main indication for THA was femoral head necrosis. The minimum followup was 1 year (mean, 6.9 years; range, 1–26.5 years). We documented 17 revisions (13%) for aseptic loosening. Twelve were for isolated acetabular loosening, two for isolated femoral loosening, and three for loosening of both components. Survivorship was 82.1% at 10 years and 72.4% at 15 years. Inferior survivorship was observed for THA performed after secondary arthritis related to slipped capital epiphysis or trauma. Limited osteolysis was observed in one hip. The main limiting factor in this series was the fixation of the acetabular component. However, improvements in the design and in the mode of fixation of this component should enhance long-term results. Level of Evidence: Level IV, therapeutic study. See the Guidelines for Authors for a complete description of levels of evidence.

Pourreyron, D.; Raould, A.; Hannouche, D.; Sedel, L.

2008-01-01

97

Increasing incidence of hip arthroplasty for primary osteoarthritis in 30- to 59-year-old patients  

PubMed Central

Background and purpose The use of hip arthroplasties is evidently increasing, but there are few published data on the incidence in young patients. Methods We used data on total and resurfacing hip arthroplasties (THAs and RHAs) from the Finnish Arthroplasty Register and population data from Statistics Finland to analyze the incidences of THA and RHA in patients aged 30–59 years in Finland, for the period 1980 through 2007. Results The combined incidences of THAs and RHAs among 30- to 59-year-old inhabitants increased from 9.5 per 105 inhabitants in 1980 to 61 per 105 inhabitants in 2007. Initially, the incidence of THA was higher in women than men, but since the mid-90s the incidences were similar. The incidence increased in all age groups studied (30–39, 40–49, and 50–59 years) but the increase was 6-fold and 36-fold higher in the latter two groups than in the first. The incidence of THA was constant; the increased incidence of overall hip arthroplasty was due to the increasing number of RHAs performed. Interpretation We have found a steady increase in the incidence of hip arthroplasty in patients with primary hip osteoarthritis in Finland, with an accelerating trend in the past decade, due to an increase in the incidence of RHA. As the incidence of hip osteoarthritis has not increased, the indications for hip arthroplasty appear to have become broader.

2011-01-01

98

Henoch-Schöenlein purpura and diabetes mellitus in a 9-year-old African-American male.  

PubMed

A 9-year-old boy with a past medical history of asthma was admitted from the emergency department (ED) for evaluation of a rash, polyarthralgia, and hyperglycemia noted at the referring hospital. The rash was reported as purpuric "bumps," which started 3 days prior to presentation. The rash had initially presented on the lower extremities and had progressively worsened as well as spread to both upper extremities. He also complained of pain in his right knee and lower extremity swelling with limited flexion bilaterally. There was no history of polyphagia, polydipsia, nausea, vomiting, diarrhea, abdominal pain, headache, or fever. The patient mentioned that he had lost approximately 10 lbs during the past year, but he had been trying to lose weight. PMID:24605861

D'Souza, Shalome; Hageman, Joseph R; Patel, Payal; Littlejohn, Elizabeth

2014-03-01

99

Multiple supernumerary teeth in a nonsyndromic 12-year-old female patient - a case report.  

PubMed

Supernumerary teeth (ST) are uncommon alterations of development that may appear in either of the dental arches and that are frequently associated with syndromes such as cleidocranial dysplasia and Gardner syndrome. Multiple ST in individuals with no other disease or syndrome are very rare. In view of this situation, correct diagnosis, treatment and evaluation of ST with the use of appropriate imaging techniques are highly important. This case report presents radiographic images of a nonsyndromic 12-year-old female patient who presented with 14 supernumerary teeth and was treated under general anesthesia, with the extraction of all ST in a single surgical intervention. During the postoperative period, the patient did not complain of pain nor did she present any signs or symptoms of infection. During late follow-up period, due to difficulty in traction of the maxillary right canine and mandibular left first premolar towards the dental arch, it was necessary to extract these teeth under local anesthesia. Radiographic examination 3 years after surgery revealed the absence of ST and of diseases related to the existence of these teeth. PMID:24789298

Santos, Thiago de Santana; Silva, Erick Ricardo; Faria, Ana Célia; Mello Filho, Francisco Veríssimo de; Xavier, Samuel Porfírio

2014-01-01

100

Acute unintentional intoxication with paraffin in a 25-year old patient - Clinical case report.  

PubMed

"Fire-breathing" or "fire-eating" is a special kind of street art where the acts are always stunning, spectacular and amazing. People exhibiting this kind of show are professionals, not rare amateurs, who use different kind of fuels, usually hydrocarbons, in order to produce a pillar of fire. Intoxications caused by ingestion or inhalation of liquid paraffin, used as a fuel while performing, are numerous and various. We present a clinical case report of a 25-year old, previously healthy, amateur "fire-breather". During October, 2010 this young men arrived at the Emergency Unit of the University Clinic for toxicology and Urgent Internal Medicine in a severe clinical condition, after his unsuccessful attempt to perform real "fire-breathing". He had fever, strong headaches, mild abdominal and chest pain and he also had difficulties breathing and persistent dry cough. The patient was extremely dyspneic with peripheral cyanosis and shortness of breath. "Fire-breathers" must be viewed as a population at risk of paraffin-induced pneumonia, which has low mortality rate, but still is related with numerous and various chronic complications. Our patient was first in a life threatening, extremely serious clinical condition which was urgently treated with appropriate vigorous and effective therapy. This therapeutic protocol led to successful full recovery of these young men, who luckily didn't exhibit any chronic complications. PMID:25066163

Chibishev, Andon; Simonovska, Natasa

2014-08-01

101

Evaluation of grafted patients with donor corneas that today are more than 100?years old.  

PubMed

Purpose:? Life expectancy is increasing. When corneal donors become older and corneal-grafted patients live longer with their graft, the need for good-quality donor tissue becomes more crucial. The aim of the present investigation is to study grafted recipients with a donor cornea with a total tissue age of more than 100?years. Methods:? One thousand consecutive donor records from the Danish Cornea Bank were initially reviewed. After applying different inclusion criteria, 35 recipients with corneal donor tissue of more than 100?years of age were invited for a follow-up visit. Visual acuity, corneal transparency and thickness, and intraocular pressure were measured. Corneal topography and endothelial photos were taken. Results:? Seventeen of the invited patients attended the examination. The average age of the grafts at examination was 107?years old; the oldest being 118?years. Most grafts were still clear 23-35?years after transplantation, and almost one-fourth had best spectacle-corrected visual acuity (BSCVA)???0.50. Cell morphology showed irregularity in size and shape for both grafted and healthy corneas, but the alterations were more extensive in the grafted corneas. The average endothelial cell density (ECD) was 1360?mm(2) in the grafted corneas. Sixty per cent had ECD?>?1000?cells/mm(2) . No signs of decompensation were observed for those with <1000?cells. The average central corneal thickness of the grafts was 0.582?mm (SD?=?0.067) compared with 0.494?mm (SD?=?0.043) in the fellow cornea. Conclusion:? This study shows a trend of moderate long-term survival and quality for very old grafts despite low ECD. Most recipients had a clear transplant, and one-fifth had BSCVA of 0.80. PMID:23819790

Visby, Elizabeth; Hjortdal, Jesper; Nielsen, Kim

2014-08-01

102

Mucin-producing Malignant Tumor of Lower Eyelid Presenting in a 14-year-old Patient  

PubMed Central

Malignancies of the ocular adnexa are rare, aggressive tumors with significant potential for local recurrence and metastases. Although basal cell carcinoma remains the most common malignancy of the eyelid, encompassing more than 90 percent of all periocular cancers, several other malignant neoplasms have been reported. Malignant ocular adnexal neoplasms are most commonly of sweat gland origin and include hidradenocarcinoma, mucinous eccrine adenocarcinoma, and apocrine adenocarcinoma of the glands of Moll. The different ocular adnexal adenocarcinomas share many of the same characteristics with regard to incidence, primary location, and rates of recurrence and metastases. As a result, these tumors are difficult to distinguish clinically and true diagnosis depends on histological findings. The highest incidence of the reported cases occurred during the sixth decade of life. The head, neck, and trunk are the most frequently reported primary locations. Ocular adnexal adenocarcinomas have a significant rate of metastasis to regional lymph nodes as well as distant sites. Standard treatment of care includes surgical excision of the tumor; however, these malignancies have a tendency to recur locally. The authors present a 14-year-old Caucasian girl with no significant past medical history who presented with a recurrent right lower eyelid tumor. She previously had multiple resections at an outside hospital; however, the margins could not be cleared. The patient was taken to the operating room for Mohs-type resection of the primary site as well as a right parotidectomy with facial nerve preservation and right modified radical neck dissection. The final pathology was consistent with a mucin-producing malignant tumor of ocular adnexa. Due to the great potential for local recurrence and metastases, the prognosis for ocular adnexal adenocarcinoma remains poor even with aggressive surgical management. The use of Mohs surgery for resection has increased as it has been linked to prolonged intervals of metastatic-free disease.

Latorre, Andrea; Alghothani, Lana; Jatana, Kris R.; Peters, Sara; Foster, Jill; Hill, Robert

2012-01-01

103

An aggressive "double-hit" lymphoma occurring in a 42-year-old male with both MYC and t(14;18) translocations.  

PubMed

We describe a 42-year-old male who was in good health until he presented with a high grade B-cell non-Hodgkin lymphoma/leukemia that had both MYC and t(14;18) translocations. This process has now been classified as "B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma and Burkitt lymphoma," according to the 2008 World Health Organization Classification of Tumours of Haematopoitic and Lymphoid Tissues. The clinical presentation, pathologic work-up including examination of the peripheral blood, lymph node biopsy, bone marrow aspiration and biopsy are included. Treatment consisted of seven cycles of chemotherapy following the CALGB protocol 9251. Prognosis is generally reported as poor in these aggressive "double-hit" lymphomas. However, this patient's disease has now been in remission for two years. PMID:20860118

Laudenschlager, Mark D; Geis, Michael C

2010-09-01

104

Signet Cell Carcinoma of Colon in a Nineteen-Year-Old Patient: A Case Report  

PubMed Central

Signet cell carcinoma, which is a subtype of adenocarcinoma, usually originates from the stomach. However, it can also originate from the colon, rectum, gallbladder, pancreas, urinary bladder, and breast. We represent a 19-year-old boy diagnosed with signet cell tumour while he was being evaluated for an initial diagnosis of inflammatory bowel disease.

Pamukcu, Ozgul; Selcukbiricik, Fatih; Bilici, Ahmet; Sak?z, Damlanur; Ozdogan, Osman; Borlu, Fatih

2013-01-01

105

Isolated defect of peroxisomal ?-oxidation in a 16-year-old patient  

Microsoft Academic Search

We describe a 16-year-old boy suffering from psychomotor retardation, sensorineuronal hearing impairment, peripheral neuropathy, hepatosplenomegaly, short stature and delayed puberty. Postnatally, muscular hypotonia, mild facial dysmorphism and delayed fontanelle closure had been noticed. At the time of our examination, adrenal cortical function was normal. Biochemical analysis revealed accumulation of very long (>C22) chain fatty acids in plasma and fibroblasts. Furthermore,

R. Santer; A. Claviez; H. D. Oldigs; J. Schaub; R. B. H. Schutgens; R. J. A. Wanders

1993-01-01

106

Atrioventricular thrombus in a 14-year-old patient: a case report  

PubMed Central

Right atrioventricular thrombus was diagnosed by echocardiography in a 14-year-old boy. Thrombus was reached through the right ventricle to the pulmonary artery and it was caused to tricuspit valve insufficiency. Surgical thrombectomy was performed and, he was treated with oral anticoagulation in postoperative period.

2010-01-01

107

[Abdominal CSF pseudocyst recurrence in a 14-year-old patient with ventricular-peritoneal shunt].  

PubMed

Abdominal cerebrospinal fluid (CSF) pseudocyst is a rare complication of ventricular-peritoneal shunt (VPS) but needs to be considered in every patient with abdominal complaints or signs of intracranial hypertension (IH). The pathogenesis of pseudocysts remains unclear. Diverse predisposing factors have been proposed such as previous abdominal surgeries, multiple VPS revisions, infections, history of necrotizing enterocolitis, and nonspecific inflammatory processes. We report the case of a 14-year-old patient, known to have a VPS as intraventricular hemorrhage treatment, presenting cephalalgia, vomiting, apathy, and an indurate abdominal mass without fever. The first abdominal CSF pseudocyst diagnosis had been established 3months earlier. Abdominal ultrasounds confirmed a large homogeneous cyst with the shunt tip within the pseudocyst. Cerebral CT revealed an increased ventricular size. An exploratory laparotomy with cyst aspiration, lysis of adhesions, excision of cystic walls, and repositioning of the peritoneal catheter was performed. No antibiotics were initiated given that the cultures were negative. Ultrasonography proved to be the method of choice in the diagnosis of VPS abdominal complications, especially CSF pseudocyst. CT can also reliably confirm the pseudocyst. In case of IH signs, a cerebral CT scan can be performed to evaluate the ventricular distension and to check the shunt position. Various methods to process the cyst have been described in the medical literature, but the recurrence rate remains elevated (25-100%). Then the probability of an infection without any clinical sign has to be considered. In case of suspected infection, the VPS is removed and replaced by an external ventricular drain. Antibiotics are started and adjusted to the results of the CSF culture. If there is no direct sign of infection, only the distal catheter is externalized and antibiotics are introduced until infection is treated. Depending on the peritoneal absorption state, the distal catheter is replaced in the abdominal cavity or in the atrium, the pleural space or the gallbladder if there is no suitable place for repositioning. If the peritoneal state allows it, a laparoscopic procedure is recommended to avoid peritoneal adhesion formation increasing the recurrence rate of CSF pseudocyst. PMID:24997061

Laurent, P; Hennecker, J-L; Schillaci, A; Scordidis, V

2014-08-01

108

Verocytotoxin-Producing Escherichia coli O128ab:H2 Bacteremia in a 27-Year-Old Male with Hemolytic-Uremic Syndrome  

PubMed Central

Verocytotoxin-producing Escherichia coli (VTEC) strains of serotype O128ab:H2 were isolated from blood and stool of a 27-year-old male presenting diarrhea-associated hemolytic-uremic syndrome complicated by bacteremia. This report once again illustrates the pathogenic potential of a non-O157 VTEC strain carrying a virulence profile previously associated with mild disease.

Buvens, Glenn; De Rauw, Klara; Roisin, Sandrine; Vanfraechem, Gaelle; Denis, Olivier; Jacobs, Frederique; Scheutz, Flemming

2013-01-01

109

The Effect of ROSHI Protocol and Cranial Electrotherapy Stimulation on a Nine-Year-Old Anxious, Dyslexic Male with Attention Deficit Disorder: A Case Study  

Microsoft Academic Search

This case study describes diagnosis and treatment of a nine-year-old male with poor reading achievement, attention deficit disorder, and severe generalized anxiety disorder. The goal of the treatment was to significantly increase this young man's reading achievement, reduce his anxiety to a normal level, and to reduce his ADD symptoms so he could concentrate at a normal level for his

Stephen J. Overcash

2005-01-01

110

Complex percutaneous coronary intervention of the left coronary artery with rotational atherectomy in an 84-year-old dialysed patient.  

PubMed

Coronary artery disease in patients with end-stage renal disease occurs several dozen times more often than in the general population. Atherosclerotic changes in coronary arteries in dialysed patients are more diffused and calcified, which hampers the percutaneous coronary angioplasty. We present a case of an 84-year-old dialysed patient, in whom complex percutaneous coronary intervention of the left anterior descending artery was performed with the use of rotational atherectomy. PMID:24570743

Zalewska-Adamiec, Ma?gorzata; Kralisz, Pawe?; Bachórzewska-Gajewska, Hanna; Dobrzycki, S?awomir

2013-01-01

111

A Case Report: Angiomatoid Fibrous Histiocytoma in a 6-year-old Male and Review of the Literature.  

PubMed

Angiomatoid Fibrous Histiocytoma (AFH) is a distinctive tumor in children, adolescent and young adults which is slow growing with metastatic potential. The histogenesis of AFH is uncertain. Here, we present a case of AFH of 6-year-old on the trunk. In addition, the differential diagnosis for this lesion is also discussed. PMID:24521435

Kaygusuz, Ecmel Isik; Cetiner, Handan; Yorganci, Cuma; Celayir, Aysenur

2014-06-01

112

Pathologic fracture of the distal radius in a 25-year-old patient with a large unicameral bone cyst  

PubMed Central

Background Distal radius fractures (DRF) are often referred to as osteoporosis indicator fractures as their incidence increases from age 45. In the group of young adults, distal radius fractures normally result from high-energy trauma. Wrist fractures in young patients without adequate trauma thus raise suspicion of a pathologic fracture. In this report we present the case of a fractured unicameral bone cyst (UBC) at the distal radius in a young adult. To the author’s best knowledge, this is the first detailed report in an UBC at the distal radius causing a pathologic DRF in an adult patient. Case presentation A 25-year-old otherwise healthy male presented to our Emergency Department after a simple fall on his right outstretched hand. Extended diagnostics revealed a pathologic, dorsally displaced, intra-articular distal radius fracture secondary to a unicameral bone cyst occupying almost the whole metaphysis of the distal radius. To stabilize the fracture, a combined dorsal and volar approach was used for open reduction and internal fixation. A tissue specimen for histopathological examination was gathered and the lesion was filled with an autologous bone graft harvested from the ipsilateral femur using a reamer-irrigator-aspirator (RIA) system. Following one revision surgery due to an intra-articular step-off, the patient recovered without further complications. Conclusions Pathologic fractures in young patients caused by unicameral bone cysts require extended diagnostics and adequate treatment. A single step surgical treatment is reasonable if fracture and bone cyst are treated appropriately. Arthroscopically assisted fracture repair may be considered in intra-articular fractures or whenever co-pathologies of the carpus are suspected.

2014-01-01

113

Mucinous Cystadenoma Arising in a Mature Cystic Teratoma in a 25-Year-Old Patient  

PubMed Central

Coexistence of a mucinous cystadenoma arising in a mature cystic teratoma is infrequently reported. Herein a case of a 25-year-old woman diagnosed with a right ovarian mucinous cystadenoma arising in a mature cystic teratoma is reported. She presented with lower right abdominal discomfort. Ultrasound showed a 14.8 × 7.9 × 12.5?cm structure on the right adnexa. She underwent a diagnostic laparoscopy, which was converted to exploratory laparotomy, during which a right salpingo-oophorectomy was performed.

Pintea, Michelle D.

2014-01-01

114

Immunofluorescence study of a muscle biopsy from a 1-year-old patient with Walker-Warburg syndrome  

Microsoft Academic Search

A previous study of two patients with Walker-Warburg syndrome (WWS) showed a severe deficiency of the extracellular matrix\\u000a protein laminin ?2 chain and ?-sarcoglycan (adhalin) in skeletal muscle fibers. More recently, however, other researchers\\u000a have shown that in their WWS patients the expression of the laminin ?2 chain and ?-sarcoglycan was normal. Here we describe\\u000a a 1-year-old boy affected with

Marcello Villanova; Patrizia Sabatelli; Yi He; Alessandro Malandrini; Stefania Petrini; Nadir M. Maraldi; Luciano Merlini

1998-01-01

115

Unicystic ameloblastoma in 3 year old paediatric patient - A rare entity  

PubMed Central

Unicystic ameloblastoma (UA) is a benign epithelial odontogenic tumor of the jaws that commonly occurs in 2nd and 3rd decade of life. In fact, this entity is rare in children under 12 years of age. It is characterised as a distinct variant of ameloblastoma, exhibiting a less aggressive behaviour and a lower rate of recurrence than solid conventional ameloblastoma. There are very few reported cases of UA occurring in children below five years of age. The purpose of this case report is to describe a case of UA involving the crown of an unerupted maxillary second premolar in a 3 year old girl. The pathogenesis, clinical appearance, radiographic presentation, histological findings and management of the tumour have also been discussed.

Kumar, Priya; Urs, Aadithya B.; Augustine, Jeyaseelan

2013-01-01

116

Laparoscopic adrenalectomy of an adrenal adenoma with myelolipoma relieves severe hypertension in a 16-year-old patient  

Microsoft Academic Search

Adrenal adenoma with myelolipoma is extremely rare in pediatrics. Although the tumor is usually asymptomatic, sometimes it may result in serious manifestations. A 16-year-old patient was diagnosed with severe hypertension associated with a right adrenal mass. The laboratory work-up was inconclusive of the nature of the tumor. Plasma and urinary hormonal studies were not diagnostic. Magnetic resonance imaging (MRI) of

Rana F. Ammoury; Rubina A. Heptulla; Nina Tatevian; Ewa Elenberg

2006-01-01

117

Radiographically Negative, Asymptomatic, Sentinel Lymph Node Positive Cutaneous T-Cell Lymphoma in a 3-Year-Old Male: A Case Report  

PubMed Central

We present a case of a 3-year-old male originally diagnosed with a CD30+ anaplastic cutaneous T-cell lymphoma with no evidence of systemic disease after CT scan, PET scan, and bone marrow aspiration. Sentinel lymph node biopsy (SLNB) was performed as an additional step in the workup and showed microscopic disease. Current management/recommendations for cutaneous T-cell lymphoma do not include SLNB. Medical and surgical management of cutaneous malignancies is dramatically different for local versus advanced disease. Therefore adequate evaluation is necessary to properly stage patients for specific treatment. Such distinction in extent of disease suggests more extensive therapy including locoregional radiation and systemic chemotherapy versus local excision only. Two international case reports have described SLNB in cutaneous T-cell lymphoma with one demonstrating evidence of node positive microscopic disease despite a negative metastatic disease workup. This case is being presented as a novel case in a child with implications including lymphoscintigraphy and SLNB as a routine procedure for evaluation and staging of cutaneous T-cell lymphoma if the patient does not demonstrate evidence of metastatic disease on routine workup.

Carson, Jeffrey; Bedrnicek, Jiri; Abdessalam, Shahab

2012-01-01

118

P05.07. Chronic Fatigue, Depression, and Sleep Disturbances in a 20-year-old Male Collegiate Basketball Player: A Case Report  

PubMed Central

Focus Areas: Integrative Approaches to Care, Mental Health Chronic fatigue and depression are 2 symptoms that are increasing in frequency in the offices of physicians. Many of these individuals need obvious dietary and lifestyle changes as primary management. In contrast, this case report illustrates a 20-year-old male collegiate basketball player suffering from chronic fatigue, depression, and abnormal sleep patterns. This patient was being treated by a specialty physician group with the diagnoses of chronic fatigue syndrome and overtraining syndrome. The patient was under the care of the same physician group at the time of his initial visit to a chiropractic physician that specialized in functional medicine. Adrenal stress panel showed that the patient was in second-stage adrenal syndrome. Pathological gastrointestinal testing revealed Helicobacter pylori, Giardia, Entamoeba histolytica, and Cryptosporidium parvum infections. Heavy metal toxicity of lead and mercury also were present in this individual. Abnormal amino acid levels were seen when evaluating organic cation transporter (OCT2) status. In addition to changing to an ancestral diet and recommending a core multivitamin, antioxidant, and essential fatty acid supplementation, other personalized recommendations were given to the patient according to the results of the functional labs. The patient was given recommended specific dosages of DHEA, licorice root, pregnenlone to reduce adrenal syndrome; botanical antimicrobial and antiparasitic supplementation; additional nutrients and silymarin to reduce heavy metal toxicity; and a protocols of 5-HTP and tyrosine to restore proper OCT2 function to presynaptic nerves. After treatment, the patient experienced restoration of normal sleep patterns and elimination of his depression and chronic fatigue and was able to exercise and maintain a normal lifestyle. This case showed that uncommon patient populations can suffer from chronic fatigue secondary to subclinical infections regardless of apparent health status and also that functional analysis of the organ systems of adrenal, gastrointestinal, and detoxification can assist in complex cases.

2013-01-01

119

Recurrent vitreous hemorrhage associated with regressed retinopathy of prematurity in a 47-year-old patient: a case report  

PubMed Central

Introduction Vitreous hemorrhage associated with retinopathy of prematurity is often seen in childhood, but adult onset without retinal break is rare. We describe a case of recurrent vitreous hemorrhage associated with regressed retinopathy of prematurity in a 47-year-old patient. Case presentation A 47-year-old Japanese woman with a history of retinopathy of prematurity presented with a visual disturbance in her left eye due to vitreous hemorrhage. Because the vitreous hemorrhage was recurrent and refractory, we performed pars plana vitrectomy combined with lens extraction by phacoemulsification and intraocular lens implantation. No retinal break or retinal detachment was found. No vitreous hemorrhage or other complication occurred in the first six months after surgery. Conclusions Vitrectomy, potentially in combination with lens extraction, should be considered in adult-onset recurrent vitreous hemorrhage associated with retinopathy of prematurity.

2014-01-01

120

Left-sided liver and right sided Polysplenia: a 77-year-old patient with hetrotaxy syndrome.  

PubMed

Hetrotaxy syndrome is defined as an abnormality where the internal thoraco-abdominal organs demonstrate abnormal arrangement across the left-right axis of the body. Although it is a known condition among physicians taking care of pediatric patients, it is rarely seen in adult day-to-day medicine and most physicians involved in care of adult patients are unaware of it. It is important to recognize this anomaly based on clinical findings,due to its reported association with various medical conditions. We report a case of a 77-year-old patient diagnosed with Hetrotaxy syndrome. PMID:24592618

Brahmbhatt, Parag; Barad, Bhavesh; Panchal, Mehul; Bhavsar, Vedang; Atif, Saleem; Klosterman, Lance

2014-01-01

121

Mini-dose GnRH-a long versus short protocol in patients ?35 years old undergoing in vitro fertilization.  

PubMed

Abstract Purpose: To compare the clinical result of mini-dose GnRH-a long protocol with short protocol in older patients undergoing IVF. Materials and methods: This was a retrospective study. Four hundred and sixty-one women aged above 35-year-old in first cycle were assigned to two groups: GnRH-a short protocol (n?=?359); and mini-dose GnRH-a long protocol (n?=?102). Both groups were divided based on their age, into groups over and under 38 years old. Primary outcome include live birth rate per started cycle. Other clinical outcomes were good-quality embryo rate, clinical pregnancy rate. Results: Patients treated with mini-dose GnRH-a protocol and those treated with short protocol showed similar live birth rate. In the mini-dose long protocol group aged 35-38 years old, patients showed significantly thicker endometrium at the day of hCG administration, higher number of good embryos obtained and higher good-quality embryo rate (56.3% versus 46.5%) compared with short protocol. The implantation rate and clinical pregnancy rate were higher versus short protocol group, but this result was not statistically significant. Conclusion(s): Mini-dose GnRH-a long protocol for older women is at least as effective as short protocol, especially in patients aged 35-38 years, with a better good-quality embryo rate and higher number of good embryos obtained, therefore mini-dose GnRH-a long protocol can be considered as an alternative protocol for patients above 35 years age. PMID:24693851

Xu, Hai-Jing; Ji, Xiao-Wei; Hong, Yan; Zhu, Qin-Ling; Zhao, Xiao-Ming; Sun, Yun

2014-07-01

122

Involved-field radiotherapy is effective for patients 70 years old or more with early stage non-small cell lung cancer  

Microsoft Academic Search

Background and purposeNon-small cell lung cancer (NSCLC) accounts for approximately 80–85% of all lung cancers, especially in patients 70 years old or more. In this study, we investigated the efficacy and safety of involved-field radiotherapy (IFRT) for patients 70 years old or more with early stage NSCLC.

Hui Ming Yu; Yun Fang Liu; Jin Ming Yu; Jie Liu; Yuxia Zhao; Ming Hou

2008-01-01

123

Quality of life after open-heart surgery in patients over 75 years old.  

PubMed

In a postal study we used the Nottingham Health Profile questionnaire to assess the quality of life of elderly survivors of open-heart surgery. From January 1984 to October 1993, 146 patients over 75 years of age underwent open-heart surgery in the Department of Cardiovascular Surgery at Beasançon (France). Eleven patients (7. 5%) died in the immediate post-operative course. Patients' mean follow-up was 3.4 +/- 2.4 years. Fourteen patients died during follow-up. One hundred and four completed Nottingham Health Profile questionnaires were returned. Five per cent of the patients lived in an old people's home. Six per cent of the patients were unable to walk at all. One patient out of five felt isolated. Fifteen per cent of the patients were in constant pain. Half of the patients took sleeping pills. Conversely, 87% of the patients felt an improvement after surgery. Sixty-two per cent continued to drive. Ninety-seven patients (92%) did at least one of the following three activities: watched television, listened to the radio, read books or magazines. Fifty-eight patients (56%) walked on a regular basis. The different types of pathology, of surgical procedures and whether or not a pacemaker was implanted during the post-operative course were not reflected in the quality of life (QOL) scores. After cardiac surgery, most of the patients were physically autonomous and related to their exterior world. PMID:8670522

Chocron, S; Rude, N; Dussaucy, A; Leplege, A; Clement, F; Alwan, K; Viel, J F; Etievent, J P

1996-01-01

124

A 62-year-old female patient with left-sided pleural effusion.  

PubMed

Hepatic hydrothorax is defined as a pleural effusion in patients with liver cirrhosis without primary cardiac, pulmonary or pleural disease. It is a rare but important cause of unilateral-pleural effusion. The prevalence of this complication is 5-10% of the total number of patients with advanced stages of cirrhosis. In most cases (85%), the effusion is right-sided; however, in 13% of cases it can be left-sided and bilateral in 2% of the cases. We present a case of left-sided hepatic hydrothorax in the absence of ascites in a patient with primary biliary cirrhosis. The diagnosis of cirrhosis was confirmed by the biopsy;the patient didn't have any history or any signs or symptoms of cirrhosis prior to her presentation. In the case described, the patient was treated with spirnolactone, furosemide and ursodeoxycholic acid. At follow-up after six months since the diagnosis, she was responding to treatment with no complications. This case emphasizes the importance of considering hepatic hydrothorax as an etiology of a transudative pleural effusion regardless of the presence or absence of ascites inpatients with occult cirrhosis. PMID:24138689

Alhaji, Mohammad; Sadikot, Ruxana T

2013-10-01

125

Sudden elevation of liver enzymes in a 64-year-old patient: a case report  

PubMed Central

Eradication of Helicobacter pylori usually consists of a 7-day course of triple therapy including metronidazole or amoxicillin plus clarithromycin plus a proton pump inhibitor. We report about a rare adverse event of Hp eradication in a patient with moderate chronic and moderate active pangastritis. Shortly after the end of treatment cholestatic hepatitis occurred which was most likely related to clarithromycin, perhaps enhanced by amoxicillin. Since liver dysfunction was self-limited, no further treatment was required. In summary, clinicians should be aware about the presented rare adverse event of Helicobacter pylori eradication treatment for a close monitoring of those patients and rapid management of acute liver failure.

2009-01-01

126

18-year old patient with extrahepatic biliary duct carcinoid - case report.  

PubMed

Abstract Most patients with obstructive jaundice caused by an etiology other than choledocholithiasis are at risk of adenocarcinoma development. Other types of tumors are less common, although more benign. The presented study described management in case of liver hilar tumors with special regards to common hepatic duct carcinoids. PMID:24578453

Ryka?a, Cezary; Bartosiewicz, Jacek; Pawlak, Jacek; Nawrocka-Kunecka, Agnieszka; Omulecka, Aleksandra

2014-01-01

127

[A 52-year old female patient with recurrent shock of unclear origin, hemoconcentration and hypoalbuminemia].  

PubMed

Systemic capillary leak syndrome is a rare life threatening condition of unknown etiology. It was firstly described by Clarkson et al in 1960. It is characterised by recurrent attacks of severe hypovolemic shock, hemoconcentration and hypalbuminemia, caused by a sudden reversible increase in capillary permeability and shift of fluid and macromolecules to the extravascular compartment. A monoclonal paraprotein is always detectable in the serum of patients, without evidence of multiple myeloma. We describe the course of a patient, who died at a severe attack despite of prophylactic treatment after 25 months of illness. Application of cytostatics should be considered if prophylactic treatment fails even if there is no evidence of progression to multiple myeloma. PMID:15014888

Müller, M; Schmidt, A

2004-05-01

128

Laparoscopic versus Open Radical Cystectomy for Elderly Patients over 75-Year-Old: A Single Center Comparative Analysis  

PubMed Central

Purpose To explore the morbidity, mortality and oncological results of laparoscopic radical cystectomy (LRC) in the elderly patients over 75-year-old in contrast with open radical cystectomy (ORC). Materials and Methods We analyzed 46 radical cystectomies from January 2009 to December 2013 in patients over 75-year-old in our institute, 21 patients in the LRC group and 25 in the ORC group. Demographic parameters, operative variables and perioperative outcome were retrospectively collected and analyzed between the two groups. Perioperative morbidity and mortality were categorized as early (within 90 days after surgery) or late (more than 90 days) according to the time of occurrence. Results Patients in both groups had comparable preoperative characteristics. A significant longer operative time (418 vs. 337 min, p?=?0.018) and less estimated blood loss (400 vs. 500 ml p?=?0.038) were observed in LRC group compared with ORC group. Infection and ileus were the most common early complications after surgery. Patients underwent ORC suffered from significantly more postoperative ileus (28.0% vs. 4.8%, P?=?0.038) and infection (40% vs. 9.5%, P?=?0.019) than LRC group within 90 days after surgery. The mortality rate was 4.7% (1/21) and 4% (1/25) for LRC group and ORC group respectively. At a median follow-up of 21 months (range 2–61 months), the Kaplan-Meier survival curves and log-rank analysis demonstrate that there were no significant differences between the LRC and ORC groups in the 3-year overall, cancer-specific, or recurrence-free survival rates. Conclusions It is suggested that LRC should be recommended as the primary intervention to treat muscle invasive or high risk non-muscle invasive bladder cancer in elderly patients with a relative long life expectancy.

Yu, Xiaowen; Song, Ruixiang; Wei, Rongchao; Zhao, Junjie; Wang, Linhui; Hou, Jianguo; Sun, Yinghao; Xu, Chuanliang

2014-01-01

129

Unprotected Left Main Percutaneous Coronary Intervention in a 108-Year-Old Patient  

PubMed Central

With the increase in life expectancy, the proportion of very elderly people is increasing. Coronary artery disease (CAD) is an important cause of mortality and morbidity in this age group, for which myocardial revascularization is often indicated. Percutaneous coronary intervention (PCI) in the very elderly bears the inherent risks of complications and mortality, but the potential benefits may outweigh these risks. A number of observational studies, registries, and few randomized controlled trials have shown the safety and feasibility of PCI in octogenarians and nonagenarians. However, PCI is only rarely done in centenarians; so, the outcome of percutaneous coronary revascularization in this age group is largely unknown. PCI in a centenarian with complex CAD is described here; the patient presented with unstable angina despite optimum medical therapy, and surgery was declined. Good angiographic success was followed by non-cardiac complications, which were managed with a multidisciplinary approach.

Rahman, Afzalur

2014-01-01

130

Littoral cell angioma of the spleen mimicking posttransplantation lymphoma in a 63-year-old renal transplant patient.  

PubMed

In addition to lymphomas, vascular tumors represent the most common neoplasms of the spleen. Littoral cell angiomas are benign vascular tumors originating from the littoral cells lining the splenic sinuses. In this report, we describe the case of a 63-year-old patient who developed night sweats 16 months after renal transplantation. Diagnostic workup showed multiple splenic masses believed to represent lymphoma infiltration to the spleen. Lymph nodes and bone marrow were unaffected, and diagnostic splenectomy was performed. Histological examination of the pathological specimen from the splenectomy specimen showed multiple littoral cell angiomas of the spleen. We recommend that physicians involved in the area of organ transplantation, especially kidneys, remain alert for other rarer splenic lesions in transplant recipients than posttransplantation lymphoma. More specific tools need to be developed to aid in the differential diagnosis of splenic masses to avoid splenectomy in patients with littoral cell angiomas. PMID:18479795

Mühlfeld, Anja Susanne; Eitner, Frank; Perez-Bouza, Alberto; Knuechel, Ruth; Heintz, Bernhard; Floege, Jürgen

2008-09-01

131

Developmental venous anomaly with contralateral impaired venous drainage in a 17-year-old male. A case report.  

PubMed

Developmental venous anomalies (DVA) drain normal neural tissue and are mostly discovered incidentally. We describe a young patient with a left hemisphere superficial to deep DVA and right hemisphere venous outflow restriction presenting with a seizure. The right hemisphere drainage variation is not typical of a DVA but represents another drainage pattern on the border of normality. PMID:23472726

Enslin, J M N; Lefeuvre, D; Taylor, A

2013-03-01

132

[Snuff aspiration as a cause of recurrent pulmonary infiltrations in a 60-year-old patient with chronic renal failure].  

PubMed

Pulmonary infiltrations associated with renal failure demand several diagnostic procedures to exclude autoimmune disorders affecting both organ systems or to find an infectious cause of the disease. We report the case of a 60 year-old man with chronic renal failure and recurring pulmonary infiltrations. On admission to hospital all diagnostic parameters for systemic vasculitis, infectious or neoplastic disease were negative, including the histological report on transbronchial biopsies. Eventually, follow-up biopsies taken 3 months later showed vegetable fibres and necrosis due to intensive snuff abuse during the previous months. After the patient stopped taking snuff the pulmonary infiltrations improved quickly. Uraemic neuropathy, which may have facilitated aspiration, as well as the reduced pulmonary and systemic defence mechanisms due to chronic renal failure probably contributed to a considerable degree to the development of pulmonary infiltration. PMID:1413815

Hoppichler, F; Lechleitner, M; Prior, C H; König, P; Luef, G; Tötsch, M; Patsch, J R; Braunsteiner, H

1992-01-01

133

Prosthodontic Rehabilitation of Hereditary Ectodermal Dysplasia in an 11-Year-Old Patient with Flexible Denture: A Case Report  

PubMed Central

Hereditary ectodermal dysplasia is a rare group of inherited disorders characterized by aplasia or dysplasia of two or more tissues of ectodermal origin such as hair, nails, teeth, and skin. The dental characteristics of this syndrome include anodontia or hypodontia of the primary and/or permanent teeth, hypoplastic conical teeth, and underdevelopment of the alveolar ridges. The options for a definitive treatment plan include fixed, removable or implant-supported prostheses, singly or in combination. This clinical report describes the prosthetic rehabilitation of an 11-year-old boy with hereditary ectodermal dysplasia. Maxillary flexible removable partial denture and mandibular conventional complete denture were fabricated to establish an acceptable masticatory function, speech, and esthetics for the patient.

Jain, Neha; Naitam, Dinesh; Wadkar, Arti; Nemane, Anuradha; Katoch, Shiva; Dewangan, Ashish

2012-01-01

134

Appendectomy during the third trimester of pregnancy in a 27-year old patient: case report of a "near miss" complication.  

PubMed

The management of acute appendicitis during pregnancy is not fully established, especially regarding the choice between open and laparoscopic surgery during the third trimester. We report herein the case of a major uterine variecele hemorrhage during a laparoscopic appendectomy in a 27-year old pregnant patient at 33 weeks of amenorrhea. After conversion to a Pfannenstiel incision, the baby was delivered, the bleeding stopped and the appendectomy completed. While both mother and child fully recovered, this «near miss» complication underlines the challenges linked to the management of acute appendicitis during pregnancy. Based on a literature review, we propose an algorithm favoring the laparoscopic approach during the first and second trimesters, and the open approach during the third trimester (especially after the 26th week of amenorrhea). In case of unclear pre-operative diagnosis, a laparoscopy should be conducted even during the third trimester with a Mc Burney conversion when the diagnosis of appendicitis is confirmed. PMID:21575272

Holzer, Thomas; Pellegrinelli, Gianmaria; Morel, Philippe; Toso, Christian

2011-01-01

135

Prevalence and Geographic Distribution of Herniated Intervertebral Disc in Korean 19-Year-Old Male from 2008 to 2009: A Study Based on Korean Conscription -National and Geographic Prevalence of Herniated Intervertebral Disc in Korean 19YO Male-  

PubMed Central

Purpose This study was to determine the prevalence of herniated intervertebral disc (HIVD) among Korean 19-year-old male in a large national sample and to compare the prevalence across geographic regions based on the data of conscription. Materials and Methods We analyzed the conscription data of 615508 cases who were 19-year-old male, given an examination for conscription at nationwide Korean Military Manpower Administration from January 2008 to December 2009. Prevalence was determined by dividing the number of cases by the number of persons enrolled for 2 years. The analyses included of a cross-tabulations and nonparametric chi-square to compare the prevalence according to geographic region, disc severity, and conscription year. Results The prevalence of HIVD among 19-year-old male was 0.47%. Seoul had the highest prevalence of HIVD (total HIVD was 0.60%, and severe HIVD was 0.44%). The prevalence of HIVD was lower in Jeollabuk-do and Jeollanam-do (total HIVD was 0.25-0.27%, and severe HIVD was 0.16-0.17%). Annual prevalence of HIVD was slightly decreased in 2009, but geographic distribution annually was not different. Conclusion In Korean 19-year-old male, the national prevalence of adolescent HIVD was 0.60%, but different geographic distribution was observed. It is quite possible that secondary contributing factor(s) interfere with the different geographic prevalence of HIVD.

Lee, Sang Hun; Oh, Chang Hyun; Park, Hyeong-chun; Park, Chong Oon

2013-01-01

136

Quantification of biological tissue and construction of patient equivalent phantom (skull and chest) for infants (1-5 years old)  

NASA Astrophysics Data System (ADS)

Our main purpose in this study was to quantify biological tissue in computed tomography (CT) examinations with the aim of developing a skull and a chest patient equivalent phantom (PEP), both specific to infants, aged between 1 and 5 years old. This type of phantom is widely used in the development of optimization procedures for radiographic techniques, especially in computed radiography (CR) systems. In order to classify and quantify the biological tissue, we used a computational algorithm developed in Matlab ®. The algorithm performed a histogram of each CT slice followed by a Gaussian fitting of each tissue type. The algorithm determined the mean thickness for the biological tissues (bone, soft, fat, and lung) and also converted them into the corresponding thicknesses of the simulator material (aluminum, PMMA, and air). We retrospectively analyzed 148 CT examinations of infant patients, 56 for skull exams and 92 were for chest. The results provided sufficient data to construct a phantom to simulate the infant chest and skull in the posterior-anterior or anterior-posterior (PA/AP) view. Both patient equivalent phantoms developed in this study can be used to assess physical variables such as noise power spectrum (NPS) and signal to noise ratio (SNR) or perform dosimetric control specific to pediatric protocols.

Alves, A. F.; Pina, D. R.; Bacchim Neto, F. A.; Ribeiro, S. M.; Miranda, J. R. A.

2014-03-01

137

Acute watery diarrhea as the initial presenting feature of a pheochromocytoma in an 84-year-old female patient.  

PubMed

We report the case of an 84-year-old woman who was initially admitted to the emergency room of our institution for frank dehydration caused by acute and severe secretory diarrheas along with acidosis and hypokalemia. After extensive gastrointestinal investigations, the etiology of the diarrhea remained unclear. Because clinical symptoms and ionogram parameters worsened, despite intravenous fluids and electrolyte replacement, an abdominal CT scan was performed and unexpectedly revealed a 4.5-cm mass in the right adrenal gland. Several separate 24-hour urine catecholamines were shown to be highly elevated. The diagnosis of pheochromocytoma was confirmed by MIBG scintigraphy and MRI. Before the admission, the patient never experienced symptoms suggestive of pheochromocytoma, except dry mouth and fear of impending death on several occasions. After 2 weeks, the diarrhea stopped abruptly and spontaneously without specific medication but after adequate rehydration. The patient subsequently underwent surgical removal of the adrenal medullary mass. Postoperatively, urinary catecholamines returned to normal values. Immunohistochemical study of the tumor confirmed the diagnosis of pheochromocytoma and revealed the presence of VIP-positive cells organized as islets in scattered areas of the tissue. This case illustrates the protean mode of presentation of pheochromocytoma, as well as the ability of medullary neural crest-derived cells to produce various neuropeptides potentially responsible for a large variety of symptoms. PMID:10681641

Van Eeckhout, P; Shungu, H; Descamps, F X; Lanthier, P; Castelain, T; Saey, J P; Rettman, R; Drese, C; Colin, I M

1999-01-01

138

Endoscopic removal of subgaleal hematoma in a 7-year-old patient treated with anticoagulant and antiplatelet agents  

PubMed Central

Background: Subgaleal hematomas frequently occur in children after head trauma and extend over the cranial sutures. Although conservative treatment suffices in most cases, surgical removal of a subgaleal hematoma is indicated when the patient presents with anemia and headache associated with its progressive enlargement. Case Description: We present the case of a 7-year-old boy who was medicated with warfarin and aspirin due to a hypoplastic left ventricle and fell from a rock wherein he hit his head in the frontal region. Although a computed tomography scan of the head revealed no intracranial lesion, an extracranial hematoma was found to extend over the cranial sutures, leading to the diagnosis of subgaleal hematoma. The hematoma continued to grow gradually despite the cessation of warfarin and aspirin therapy immediately after the head trauma. Since the patient's headache and anemia were progressing as the hematoma enlarged, removal of the hematoma was performed 3 days after admission. Endoscopic hematoma removal was planned to enable accurate coagulation of the sites of bleeding and removal of the maximal amount of hematoma through minimal incision. The hematoma was completely removed, and the patient's postoperative course was excellent with alleviation of both the anemia and the headache. No sign of hematoma recurrence could be detected during 2 years follow-up. Conclusion: An angled endoscope can allow visualization of the deep subgaleal space, and this technique enabled direct visualization of the bleeding sites and accurate coagulation to prevent recurrence of hematoma. Endoscopic techniques, such as minimally invasive techniques, can allow sufficient removal of subgaleal hematoma with minimal morbidity, especially in patients such as ours.

Hayashi, Yasuhiko; Kita, Daisuke; Furuta, Takuya; Oishi, Masahiro; Hamada, Jun-ichiro

2014-01-01

139

Alzheimer-type neuropathology in a 28 year old patient with iatrogenic Creutzfeldt-Jakob disease after dural grafting  

PubMed Central

We report the case of a 28?year old man who had received a cadaverous dura mater graft after a traumatic open skull fracture with tearing of the dura at the age of 5?years. A clinical suspicion of Creutzfeldt?Jakob disease (CJD) was confirmed by a brain biopsy 5?months prior to death and by autopsy, thus warranting the diagnosis of iatrogenic CJD (iCJD) according to WHO criteria. Immunohistochemistry showed widespread cortical depositions of disease associated prion protein (PrPsc) in a synaptic pattern, and western blot analysis identified PrPsc of type 2A according to Parchi et al. Surprisingly, we found Alzheimer?type senile plaques and cerebral amyloid angiopathy in widespread areas of the brain. Plaque?type and vascular amyloid was immunohistochemically identified as deposits of beta?A4 peptide. CERAD criteria for diagnosis of definite Alzheimer's disease (AD) were met in the absence of neurofibrillar tangles or alpha?synuclein immunoreactive inclusions. There was no family history of AD, CJD, or any other neurological disease, and genetic analysis showed no disease specific mutations of the prion protein, presenilin 1 and 2, or amyloid precursor protein genes. This case represents (a) the iCJD case with the longest incubation time after dural grafting reported so far, (b) the youngest documented patient with concomitant CJD and Alzheimer?type neuropathology to date, (c) the first description of Alzheimer?type changes in iCJD, and (d) the second case of iCJD in Austria. Despite the young patient age, the Alzheimer?type changes may be an incidental finding, possibly related to the childhood trauma.

Preusser, M; Strobel, T; Gelpi, E; Eiler, M; Broessner, G; Schmutzhard, E; Budka, H

2006-01-01

140

A cost-effectiveness analysis of online, radio and print tobacco control advertisements targeting 25-39 year-old males.  

PubMed

Objective: To assess the relative cost-effectiveness of various non-television advertising media in encouraging 25-39 year-old male smokers to respond to a cessation-related call to action. Information about how new electronic media compare in effectiveness is important to inform the implementation of future tobacco control media campaigns. Methods: Two testimonial advertisements featuring members of the target group were developed for radio, press and online media. Multiple waves of media activity were scheduled over a period of seven weeks, including an initial integrated period that included all three media and subsequent single media phases that were interspersed with a week of no media activity. The resulting Quit website hits, Quitline telephone calls, and registrations to online and telephone counselling services were compared to advertising costs to determine the relative cost-effectiveness of each media in isolation and the integrated approach. Results: The online-only campaign phase was substantially more cost-effective than the other phases, including the integrated approach. Conclusions: This finding is contrary to the current assumption that the use of a consistent message across multiple media simultaneously is the most cost-effective way of reaching and affecting target audiences. Implications: Online advertising may be a highly cost-effective channel for low-budget tobacco control media campaigns. PMID:24750454

Clayforth, Cassandra; Pettigrew, Simone; Mooney, Katie; Lansdorp-Vogelaar, Iris; Rosenberg, Michael; Slevin, Terry

2014-06-01

141

Blinding Bilateral Hyperviscosity Retinopathy in a 43-Year-Old Nigerian Male with Lymphoplasmacytic Lymphoma: A Case Report and Management Challenges  

PubMed Central

Lymphoplasmacytic lymphomas are rare and may present with uncommon and devastating symptoms. We report a case of a 43-year-old male who presented with bleeding gums and sudden onset of bilateral blindness but was not on anticoagulants and had no family history of bleeding disorder. He had bilateral hyperpigmented infraorbital skin lesions, visual acuities (VA) of hand motion in both eyes (blindness), round and sluggish pupils, and bilateral diffuse and extensive retinal haemorrhages obliterating the retinal details with central visual field defects. The optical coherence tomography revealed retinal haemorrhage, oedema, detachment, and diffuse photoreceptors damage. Investigations revealed elevated ESR and ?2 microglobulin, monoclonal peak on serum protein electrophoresis, high IG with lambda restriction on serum, and urine immunofixation with increased lymphocytes and plasma cells in the bone marrow. A diagnosis of lymphoplasmacytic lymphoma complicated by blinding hyperviscosity retinopathy was made. In the absence of an aphaeresis machine, he received four cycles of manual exchange blood transfusion (EBT) and commenced with chlorambucil/prednisolone due to difficulty in obtaining blood for continued EBT. His general condition and VA has improved and he is stable for more than six months into treatment.

Ayanniyi, Abdulkabir A.; Ejikeme, Uchenna Godswill; Tanko, Yohanna; Muhammad, Rilwan C.; Nnodu, Obiageli E.

2014-01-01

142

Unusually long survival of a 67-year-old patient with near-tetraploid acute myeloid leukemia m0 without erythroblastic and megakaryocytic dysplasia.  

PubMed

Patients with near-tetraploid acute myeloid leukemia (NT-AML) typically have poor survival. We present the case of a 67-year-old Caucasian male with NT-AML M0 who had an unusually long first complete remission of 51 months and an overall survival of 80 months. The only characteristic distinguishing him from other previously described patients with NT-AML was the absence of erythroblastic and/or megakaryocytic dysplasia (EMD) at diagnosis. Molecular-genetic testing for AML fusion transcripts associated with a favorable prognosis (PML/RAR?,AML1/ETO, and CBF?/MYH11) were negative, as were other prognostic markers like MLL-PTD,FLT3-ITD, or mutations of FLT3-D835,NPM1, or CEBPA. Expression studies of ERG,MN1, and EVI1 revealed overexpression of ERG only. The absence of EMD may be a useful prognostic/diagnostic feature of this new rare subtype of NT-AML. PMID:21701158

Lemež, Petr; Klamová, Hana; Zemanová, Zuzana; Marinov, Iuri; Fuchs, Ota; Schwarz, Ji?í; B?ezinová, Jana; Provazníková, Dana; Koste?ka, Arnošt; Marková, Jana; Michalová, Kyra; Jelínek, Jaroslav

2011-01-01

143

Adenocarcinoma of the cecum manifesting as intussusception in a 16-year-old patient: Report of a case  

Microsoft Academic Search

Summary  A 16-year-old Negro girl underwent exploratory laparotomy for ileocecal intussusception and was found to have moderately well-differentiated\\u000a mucin-producing adenocarcinoma of the ileocecal valve. Specific aspects of this disease in children are discussed and an appeal\\u000a for early diagnostic studies in cases of children who complain of weight loss, chronic constipation, and abdominal pain is\\u000a made. Finally, on the basis of

Henry J. Fee; Theodore L. Schlater; A. P. Johnson; Joseph L. Alexander

1976-01-01

144

Screening colonoscopy in 40- to 50-year-old first-degree relatives of patients with colorectal cancer is efficient: a controlled multicentre study  

Microsoft Academic Search

Background and aims  Persons with a familial risk of colorectal cancer (CRC) account for about 25% of all CRC cases. The adenoma prevalence in relatives of CRC patients 50–60 years of age is 17–34%; data on younger individuals are scarce. Our aim was to prospectively define the adenoma prevalence in 40- to 50-year-old first-degree relatives of CRC patients compared to controls.Patients

Markus Menges; Johannes Fischinger; Barbara Gärtner; Thomas Georg; Dietrich Woerdehoff; Matthias Maier; Matthias Harloff; Christa Stegmaier; Jochen Raedle; Martin Zeitz

2006-01-01

145

Effect of Postmastectomy Radiotherapy in Patients <35 Years Old With Stage II-III Breast Cancer Treated With Doxorubicin-Based Neoadjuvant Chemotherapy and Mastectomy  

SciTech Connect

Purpose: Postmastectomy radiotherapy (PMRT) improves locoregional control (LRC) in patients with high-risk features after mastectomy. Young age continues to evolve as a potentially important risk factor. The objective of this study was to assess the benefits of PMRT in patients <35 years old treated with doxorubicin-based neoadjuvant chemotherapy for Stage II-III breast cancer. Patients and Methods: We retrospectively analyzed 107 consecutive breast cancer patients <35 years old with Stage IIA-IIIC disease treated at our institution with doxorubicin-based neoadjuvant chemotherapy and mastectomy, with or without PMRT. The treatment groups were compared in terms of LRC and overall survival. Results: Despite more advanced disease stages, the patients who received PMRT (n = 80) had greater rates of LRC (5-year rate, 88% vs. 63%, p = 0.001) and better overall survival (5-year rate, 67% vs. 48%, p = 0.03) than patients who did not receive PMRT (n = 27). Conclusion: Among breast cancer patients <35 years old at diagnosis, the use of PMRT after doxorubicin-based neoadjuvant chemotherapy and mastectomy led to a statistically greater rate of LRC and overall survival compared with patients without PMRT. The benefit seen for PMRT in young patients provides valuable data to better tailor adjuvant, age-specific treatment decisions after mastectomy.

Garg, Amit K. [Department of Radiation Oncology, University of Texas M. D. Anderson Cancer Center, Houston, TX (United States); Oh, Julia L. [Department of Radiation Oncology, University of Texas M. D. Anderson Cancer Center, Houston, TX (United States)], E-mail: joh@mdanderson.org; Oswald, Mary Jane; Huang, Eugene; Strom, Eric A.; Perkins, George H.; Woodward, Wendy A.; Yu, T. Kuan; Tereffe, Welela [Department of Radiation Oncology, University of Texas M. D. Anderson Cancer Center, Houston, TX (United States); Meric-Bernstam, Funda [Department of Surgical Oncology, University of Texas M. D. Anderson Cancer Center, Houston, TX (United States); Hahn, Karin [Department of Breast Medical Oncology, University of Texas M. D. Anderson Cancer Center, Houston, TX (United States); Buchholz, Thomas A. [Department of Radiation Oncology, University of Texas M. D. Anderson Cancer Center, Houston, TX (United States)

2007-12-01

146

8-year-old patient with multiple large cerebral abscesses successfully treated with stereotactic aspiration: case report and literature review.  

PubMed

The case presented herein is of an 8-year-old female with nine large brain abscesses of unknown etiology. One lesion was excised by craniotomy. Two days later, in view of impending brain herniation, the remaining eight abscesses were treated on an urgent basis by stereotactic aspiration. Immediate postoperative CT showed total disappearance of all lesions. This case demonstrates that some brain abscesses can be successfully treated utilizing a minimally invasive technique and aggressive antibiotic therapy, without necessitating surgical removal of abscess capsule, multiple aspirations, or implantation of an irrigation system. PMID:24244982

Stevens, David C; Asfora, Wilson T

2013-10-01

147

Pregnancy- and lactation-associated transient osteoporosis of both hips in a 32 year old patient with osteogenesis imperfecta.  

PubMed

Combination of osteogenesis imperfecta (OI), pregnancy, and transient osteoporosis (TO) of the hip is rare, only a few cases have been published so far. We report a 32 year old woman with OI, with TO on the right hip in her late third trimester. Non-pharmacological measures such as non-weight-bearing resulted in complete remission. Shortly after weaning, TO of the contralateral hip developed and non-pharmacological measures remained ineffective this time. Under treatment with a prostaglandin I(2) analog (iloprost), i.v. bisphosphonate (pamidronate), calcium and vitamin D supplementation rapid improvement of pain and complete remission was achieved. PMID:22579778

Pabinger, C; Heu, C; Frohner, A; Dimai, H P

2012-07-01

148

Direct evidence of attempted beta cell regeneration in an 89-year-old patient with recent-onset type 1 diabetes  

Microsoft Academic Search

Aims\\/hypothesis  We investigated whether there was evidence of attempted beta cell regeneration in the pancreas obtained from a patient with recent-onset type 1 diabetes, and if so by what mechanism this occurred.Subjects, materials and methods  We examined pancreas tissue from a lean 89-year-old patient (BMI 18.0 kg\\/m2) with recent-onset type 1 diabetes who had had a distal pancreatectomy to remove a low-grade pancreatic

J. J. Meier; J. C. Lin; A. E. Butler; R. Galasso; D. S. Martinez; P. C. Butler

2006-01-01

149

Fatality Assessment and Control Evaluation (FACE) Report: A 15-Year-Old Male Farm Laborer Dies After the Tractor He was Operating Overturned Into a Manure Pile in Pennsylvania.  

National Technical Information Service (NTIS)

A 15-year-old male farm worker (the victim) died after the tractor he was operating overturned into a manure pit. The farm is in Pennsylvania. The tractor was equipped with a manure scraper fashioned from half a tractor tire mounted on the draw bar at the...

2002-01-01

150

Is there benefit in optimising heart failure treatment in over-80 year-old patients? (HF-80 study): study protocol for a randomized controlled trial  

PubMed Central

Background An aging population and better management of various heart diseases explain the exponential growth in incidence and prevalence of chronic heart failure, with poor prognosis and heavy health costs. Medical management is codified in international guidelines. The management of heart failure in over-80 year-old patients follows these guidelines, but no clinical trials have been able to confirm benefit. Moreover, registries show down-prescription of heart failure treatments in the elderly and over-80s. Methods/Design We present the design of the HF-80 ("Is there benefit in optimising heart failure treatment in over-80 year-old patients?") study, which is a prospective randomised open-label clinical trial with blinded end-points, designed to evaluate the effect of optimising management by adhering to guidelines in over-80 year-old heart failure patients. Patients over 80 years of age admitted with acute heart failure will be included. The primary endpoint is to assess quality of life at 6 months on the Minnesota questionnaire. The secondary endpoints are to assess the effect of optimised management on quality of life, mortality, readmission for acute heart failure, cardiac fibrosis and economic data at 12 months. 80 patients will be included, divided into 2 groups: group A, with usual heart failure management by general practitioners; and group B, with optimised management based on international guidelines. Discussion It is necessary to assess the benefit of guidelines in over-80 year-old heart failure patients because of the fragility of this population and the elevated risk of iatrogenic complications. Trial Registration Clinical trials.gov number: NCT01437371.

2012-01-01

151

A 5YearOld Boy with Cryptorchidism and Pubic Hair: Investigation and Management of Apparent Male Disorders of Sex Development in Mid-Childhood  

Microsoft Academic Search

Background: Late presentation of congenital adrenal hyperplasia as a 46,XX disorder of sex development due to 11-? hydroxylase deficiency is uncommon. Such a case raises issues regarding appropriate investigation and management. Case History: A 5-year-old boy who had recently moved to the United Kingdom presented at the endocrinology clinic with recurrent abdominal pain. He was normotensive and had a history

L. S. Keir; S. O’Toole; A. L. Robertson; A. M. Wallace; S. F. Ahmed

2009-01-01

152

A Comparative Analysis of Selected Variables of 12-to-15 Year Old Males in Special Education and the Juvenile Justice System  

ERIC Educational Resources Information Center

This study identified and compared selected variables of 12-15-year-old African American young men in special education programs and the juvenile justice system. A majority of African American young men who are placed in special education programs are also involved with the juvenile justice system. Through personal observations, interviews with…

Sinclair-Blake, Leslie C.

2010-01-01

153

A two-year-old patient with an atypical expression of G M1 -?-galactosidase deficiency: Biochemical, immunological, and cell genetic studies  

Microsoft Academic Search

Cultured skin fibroblasts from a 2-year-old boy with an atypical form of ß-galactosidase deficiency have been studied. With the artificial substrate 4-methylumbelliferyl-ß-D-galactopyranoside, 5–15% residual activity was found in fibroblasts from this patient. Most of this activity was in the monomeric A form of the enzyme, very little in the multimeric B form. Km value, pH profile, and heat lability of

A. J. J. Reuser; G. Andria; E. de Wit-Verbeek; A. Hoogeveen; E. del Giudice; D. Halley

1979-01-01

154

Anti-NMDA-receptor encephalitis in a 3 year old patient with chromosome 6p21.32 microdeletion including the HLA cluster  

PubMed Central

Anti-NMDA-receptor encephalitis was initially described as a paraneoplastic disorder in young women with ovarian teratoma. We report on a 3-year-old boy who developed anti-NMDA-receptor encephalitis one month after a respiratory infection. Moreover, array-comparative genomic hybridization in this patient revealed an inherited microdeletion in chromosomeband 6p21.32, including the HLA-DPB1 and HLA-DPB2 genes. The clinical relevance of this microdeletion is discussed.

Verhelst, Helene; Verloo, Patrick; Dhondt, Karlien; De Paepe, Boel; Menten, Bjorn; Dalmau, Josep; Van Coster, Rudy

2011-01-01

155

Late-onset combined immune deficiency associated to skin granuloma due to heterozygous compound mutations in RAG1 gene in a 14 years old male.  

PubMed

We report a male with atypical severe combined immunodeficiency caused by heterozygous compound mutations c.256-257del and c.C1331T in RAG1 gene. The patient presents with recurrent bronchopneumonias with obstruction, chronic fibrosing alveolitis, complicated by respiratory failure, pulmonary hypertension and hepatosplenomegaly. He was diagnosed with agammaglobulinemia at the age of 9. His condition was complicated by granulomatous skin disease at the age of 12 despite regular IVIg substitution. Immunological presentation included profound hypogammaglobulinemia and absence of B cells. Under immunoglobulin substitution for 5 years patient has permanent lymphopenia, skewed phenotype of T cells and diminished number of recent thymic emigrants. PMID:23085344

Sharapova, Svetlana O; Migas, Alexandr; Guryanova, Irina; Aleshkevich, Svetlana; Kletski, Semen; Durandy, Anne; Belevtsev, Michael

2013-01-01

156

Cardiac muscle AMP-deaminase from a 10-year-old male heterozygous for the AMPD1 C34T mutation.  

PubMed

A C34T mutation in the AMPD1 gene is proposed to cause local or systemic augmentations in blood adenosine level and improvement of prognoses in heart diseases like congestive heart failure or heart ischemic disease. This study examines some physico-chemical properties of AMP-deaminase isolated from cardiac muscle of a 10-year-old boy heterozygote for this mutation. PMID:20544536

Rybakowska, I; Baku?a, S; Klimek, J; Milczarek, R; Smolenski, R T; Kaletha, K

2010-06-01

157

[Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH) in a 67-year-old patient with chronic coughing].  

PubMed

History and clinical findings: A 67-year-old woman with a history of chronic obstructive pulmonary disease and breast cancer developed an increase in size and number of pulmonary nodules that had previously been stable over the course of 9 years. Investigations: Thoracic computed tomography revealed a well-defined pulmonary lesion with a diameter of 1,1 × 1,1?cm, accompanied by multiple bilateral pulmonary nodules with a maximum size of 5?mm. Thoracoscopic resection of the major nodule was extended to a completive resection of an adjacent lung area that operatively showed a macroscopically noticeable hypervascularity. Histopathological examination assigned the larger lesion to a typical carcinoid; the additionally resected hypervascular lung parenchyma confirmed an accumulation of hyperplastic neuroendocrine cells in terms of a diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH). Treatment and course: Since histological examination showed an entirely resected neuroendocrine tumor classified as typical carcinoid, and considering DIPNECH to be a preinvasive lesion, the therapeutic management consisted of serial imaging by computed tomography. During the last two years, no progression of either the pulmonary lesions or of the obstructive disease was observed. Conclusion: DIPNECH is a rare, primary pulmonary process with proliferation of hyperplastic neuroendocrine cells, affecting principally middle-aged, non-smoking women. It is considered to be a precursor lesion to pulmonary carcinoid tumors. Given its only minor risk of invasive metastatic spread, serial imaging for timely detection of progressing lesions and optimizing of concomitant obstructive pulmonary disease are the preferred treatment approaches. PMID:24866961

Pizarro, C; Zhou, H; Kader, R; Kalff, J; Nickenig, G; Skowasch, D

2014-06-01

158

[A 59 year-old patient with acute anterolateral myocardial infarction, complicated by cardiogenic shock, with chest wall deformity caused by Heine-Medin disease].  

PubMed

We report a case of a 59 year-old patient in a condition of acute myocardial infarction with ST elevation, in a cardiogenic shock, with multiple cardiac arrests in mechanism of ventricular fibrillation with a significant chest wall deformity caused by Heine-Medin disease in childhood. To our knowledge, this is the first case report of a patient in critical condition with a considerable pectus deformity after poliomyelitis who needed to undergo cardiovascular angioplasty. Although severe patient's condition and numerous difficulties during percutaneous coronary intervention, therapy was successful. PMID:22430421

Arazi?ska, Agata; Kr?cki, Rados?aw; Kasprzak, Jaros?aw D

2012-01-01

159

Lynch Syndrome from a surgeon perspective: retrospective study of clinical impact of mismatch repair protein expression analysis in colorectal cancer patients less than 50 years old  

PubMed Central

Background In clinical practice, unexpected diagnosis of colorectal cancer in young patients requires prompt surgery, thus genetic testing for Lynch Syndrome is frequently missed, and clinical management may result incorrect. Methods Patients younger than 50 years old undergoing colorectal resection for cancer in the period 1994-2007 were identified (Group A, 49 cases), and compared to a group of randomly selected patients more than 50 (Group B, 85 cases). In 31 group A patients, immunohistochemical expression analysis of MLH1, MSH2 and MSH6 was performed; personal and familial history of patients with defective MMR proteins expression was further investigated, searching for synchronous and metachronous tumors in probands and their families. Results Fifty-one percent of patients did not express one or more MMR proteins (MMR-) and should be considered Lynch Syndrome carriers (16 patients, group A1); while only 31.2% of them were positive for Amsterdam criteria, 50% had almost another tumor, 37.5% had another colorectal tumor and 68% had relatives with colorectal tumor. This group of patients, compared with A2 group (< 50 years old, MMR+) and B group, showed typical characteristics of HNPCC, such as proximal location, mucinous histotype, poor differentiation, high stage and shorter survival. Conclusions The present study confirms that preoperative knowledge of MMR proteins expression in colorectal cancer patients would allow correct staging, more extended colonic resection, specific follow-up and familial screening.

2014-01-01

160

Language Development: 2 Year Olds  

MedlinePLUS

... Language Development: 2 Year Olds Ages & Stages Listen Language Development: 2 Year Olds Article Body Your two-year- ... this. At this time, there’s more variation in language development than in any other area. While some preschoolers ...

161

[40-year-old man with primary antiphospholipid syndrome].  

PubMed

We report the case o a 40-year-old male patient with "primary antiphospholipid syndrome" who developed ischemic cerebral infarctions and renal microangiopathy with infarction. A review of the literature on renal involvement in the primary antiphospholipid syndrome disclosed the differences from the antiphospholipid syndrome in the systemic lupus erythematosus. We describe the evolution of the patient at eight years, and we emphasize the importance of the treatment with warfarin. Also, we review the pathophysiology of severe secondary arterial hypertension. PMID:12497750

Rodríguez Jornet, A; Andreu, F J; Tolosa, C

2002-01-01

162

A Novel Deletion Mutation of SLC16A2 Encoding Monocarboxylate Transporter (MCT) 8 in a 26-year-old Japanese Patient with Allan-Herndon-Dudley Syndrome.  

PubMed

Allan-Herndon-Dudley Syndrome (AHDS), an X linked condition, is characterized by congenital hypotonia that progresses to spasticity with severe psychomotor delays, in combination with altered thyroid hormone levels, in particular, high serum T3 levels. Recently, this disease was proved to be caused by mutations in SLC16A2 coding for the monocarboxylate thyroid hormone transporter 8 (MCT8). Here we describe a 26-year -old Japanese patient with AHDS who had deletion of exon 3 of SLC16A2. PMID:24170966

Yamamoto, Sayaka; Okuhara, Koji; Tonoki, Hidefumi; Iizuka, Susumu; Nihei, Noriko; Tajima, Toshihiro

2013-10-01

163

Eruptive Nevi Mimicking Wart-Like Lesions under Selective BRAF Inhibition in a 37-Year-Old Female Melanoma Patient  

PubMed Central

Background The BRAF inhibitor vemurafenib is state of the art in therapy of patients with malignant melanoma in non-resectable stage III or stage IV and evidence of oncogenetic BRAF mutation. Multiple cutaneous side effects like rash and keratoacanthoma-like lesions have been described so far. Case Report We report a patient who presented multiple wart-like lesions under therapy with vemurafenib. Histologically we have seen multiple melanocytic nevi with a wart-like appearance. One melanoma in situ developed on the left forearm. Conclusions Eruptive nevi and induction of melanoma may be a further side effect in patients undergoing a therapy with BRAF inhibitors.

Schmitt, Laurenz; Schumann, Tamara; Inhoff, Oliver; Loser, Christoph; Rebel, Martin; Dippel, Edgar

2013-01-01

164

[Knotty skin tumors of an 80-year-old patient presenting with estimated diagnosis of chronic venous insufficiency].  

PubMed

Kaposi's sarcoma in HIV-infected patients is a sign of progressive immunodeficiency. It is therefore classified as an AIDS-defining disease according to the CDC classification of 1993. Before antiretroviral therapy became available, disseminated Kaposi's sarcoma was a common therapeutic problem in HIV-infected patients. Therapeutic interventions were limited and in spite of interferon, irradiation or cytostatic drugs, chances of a definitive healing were minimal.Today, disseminated Kaposi's sarcoma is rare even in specialized clinics for infectious diseases. An exception are patients who are not aware of their HIV serostatus until they are diagnosed HIV-positive and who present already with a progressive immunodeficiency. PMID:16328183

Koch, Stefanie; Göbels, Klaus; Oette, Mark; Feldt, Torsten; Leidel, Ruth; Häussinger, Dieter

2005-11-15

165

AngioJet rheolytic thrombectomy for thrombotic myocardial injury in a 15-year-old cystic fibrosis patient during lung transplantation.  

PubMed

We report on an acute myocardial injury caused by thrombotic emboli during off-pump bilateral sequential lung transplantation in a 15-year-old female patient with end-stage cystic fibrosis. A few minutes after reperfusion of the right (second sequential) allograft, the patient developed hemodynamic collapse, including hypotension, acute akinesis of the anterior and lateral myocardial walls, and severe mitral regurgitation. Thrombus was noted within the left atrium and ventricle on intraoperative transesophageal echocardiogram. After emergent cannulation for cardiopulmonary bypass, the patient underwent left cardiac catheterization with AngioJet rheolytic thrombectomy and removal of the clot from the distal left anterior descending coronary artery. Reperfusion was established without the need for stent placement or further intervention. The patient required short-term life support with venoarterial extracorporeal membrane oxygenation. PMID:22579902

Hayes, Don; Schell, Randall M; Plunkett, Mark D; Gurley, John C; Hoopes, Charles W

2012-08-01

166

A 56-year-old female patient with facio-oculo-acoustico-renal syndrome (FOAR) syndrome. Report on the natural history and of a novel mutation.  

PubMed

The facio-oculo-acoustico-renal syndrome (FOAR) is a rare autosomal recessive syndrome characterized by the presence of dysmorphic facial features, ocular anomalies, sensorineural hearing loss, and proteinuria. Diaphragmatic hernia, exomphalos, absent or abnormal corpus callosum, and myopia, can also be part of the syndrome. The disorder is caused by mutations of the LRP2 gene located on chromosome 2q23.3-q31.1. We hereby report the case of a 56-year-old female patient with typical FOAR features. Molecular study of the LRP2 gene revealed the presence of a novel splice-site mutation. In addition to what was reported in FOAR syndrome, this patient had a megadolichocolon complicated by a volvulus and a late-onset renal failure which necessitated hemodyalisis and renal transplantation. Reporting aging patients with genetic syndromes will provide information about their special needs and lead to improvements in their follow-up. PMID:19577669

Stora, Samantha; Conte, Martine; Chouery, Eliane; Richa, Sami; Jalkh, Nadine; Gillart, Anne-Céline; Joannis, Anne-Laure de; Mégarbané, André

2009-01-01

167

[19-year-old patient with adrenal cortex insufficiency--only the tip of the iceberg. Polyendocrine autoimmune syndrome type II (Schmidt syndrome)].  

PubMed

We report on a 19-year-old woman with polyglandular autoimmune syndrome type II (APS II). She was diagnosed with addison's disease and hypothyroidism due to chronic autoimmune thyroiditis. Her mother had celiac disease and her brohter had diabetes mellitus typ 1. Chronic autoimmune thyroiditis was diagnosed in her mother, subsequently. In patients and their relatives, who have autoimmune disorders, a search for autoimmune polyglandular syndrome is crucial. Consequently, it would be appropriate that the patient and all family members are asked for clinical signs and symptoms of autoimmune disorders. Annual measurement of morning cortisol, TSH and fasting plasma glucose may useful. Screening of affected individuals as well as their first-degree relatives for celiac disease is recommended. Therapy of APS II consists of hormone replacement therapy, but thyroxin replacement may induce life-threatening adrenal failure in a patient with untreated Addison's disease. Thus, in case of doubt hydrocortisone should be given before the thyroxine administration is started. PMID:18303665

Lipowsky, C; Schorl-Schweikardt, B A; Kehl, Oth; Brändle, M

2008-01-23

168

Dirofilaria repens as a cause of subconjunctival infection in a 77-years old female patient from Croatia--a case report.  

PubMed

The zoonotic parasites of the genus Dirofilaria are on the increase as an accidental finding or as a cause of disease in humans worldwide. Human dirofilariasis usually manifests as either subcutaneous infiltrates or lung parenchymal disease, in many cases asymptomatically. We report the case of a 77-year old female patient presenting with irritation and pain in her left eye. Ophthalmologic examination of the temporal part of her left eye revealed motile and threadlike organism, which was surgically extracted and morphologically identified as Dirofilaria. Further molecular diagnostics with polymerase chain reaction (PCR) confirmed that the isolated organism is Dirofilaria repens. Due to already recognized autochthonous occurrence of human dirofilariasis in Croatia, human dirofilariasis must be included in the differential diagnosis of patients presenting with subcutaneous nodules, eye affection and other potential manifestations of this disease. PMID:24308248

Sviben, Mario; Mestrovi?, Tomislav; Nemer, Khalil; Bartulovi?, Katarina Palko; Skara, Robert; Galinovi?, Gordana Mlinari?

2013-09-01

169

Locoregional Recurrence and Survival Rates after Breast-Conserving Surgery and Hormonal Therapy in 70-Year-Old or Older Patients with Stage I or IIA Breast Carcinoma  

PubMed Central

Summary Background Data for treatment of elderly women (? 70 years) with estrogen receptor-positive early stage breast cancer are available. We have compared different treatment options to determine whether lumpectomy (LU) plus adjuvant hormonal therapy (HT) is as effective as combined LU, HT, and radiotherapy (RT). Method Medical records of elderly patients over 69 years of age who had been treated for T1N0M0 (stage I) and T2N0M0 (stage IIA) at 2 different medical centers between March 2004 and January 2011 were assessed, and 35 patients were included in this study. 21 of these patients underwent only breast-conserving surgery (BCS) and HT (Group 1: T1N0M0-Group 1a, n = 16; T2N0M0-Group 1b, n = 5) and the others either BCS, HT and RT (Group 2, n = 4) or BCS, chemotherapy (CT), HT and RT (Group 3, n = 10). Adjuvant HT for all the patients comprised aromatase inhibitors. Results The mean follow-up period for Groups 1, 2 and 3 were 32.2, 31.3 and 20.4 months, respectively. No locoregional recurrence or cancer-specific mortality occurred in any of these patients; 1 patient from Group 1 died of a different cause. Discussion The BCS+HT regimen seems to be an efficient treatment option for early stage breast cancer in selected 70-year-old and older patient groups.

Soyder, Aykut; Ozbas, Serdar; Kocak, Savas

2013-01-01

170

[Use of fish oil lipid emulsions in hospitalized patients under 18 years old with abnormal results in liver tests associated with total parental nutrition].  

PubMed

Introduction: Prolonged Total Parental Nutrition (TPN) is associated with life-threatening complications in the pediatric population, being cholestasis one of the most important ones. The source of fatty acids, the amount of phytosterols and the dose of lipids in the nutritional support, have been linked to the development of this complication. Purpose: To describe the behavior of liver function tests in pediatric patients with TPN where lipid based omega 3 fatty acids (OmegavenR) were used. Methods: A retrospective research was made in a population of children under 18 years old where omega 3 fatty acids were used for a minimum of 8 days. Patients were initially classified into two groups: cholestasis and abnormal liver tests. Levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin (TB), direct bilirubin (DB) gamma glutamyl transferase (GGT) and alkaline phosphatase (AP) before and after treatment with OmegavenR was evaluated. Results: 33 patients met the inclusion criteria. At the end of treatment with OmegavenR, 82.4% of patients who initially presented cholestasis showed resolution or improvement. The group of patients with abnormal liver tests 18.8% progressed to cholestasis. Conclusions: Our study suggests that the use of OmegavenR in pediatric patients with TPN and DB ? 2 mg/dL, seem to reverse or improve cholestasis while in patients with abnormal liver tests we still don´t have clear effect. PMID:24679026

Giraldo Villa, Adriana; Henao Roldan, Catherine; García Loboguerrero, Fanny; Martínez Volkmar, María Isabel; Contreras Ramírez, Mónica María; Ruiz Navas, Patricia

2014-01-01

171

28 year old woman Patient underwent chemotherapy 5-FU/dip/VCR response. ...... Lid swelling preceded itch eyes redness conjunctive ...... 34-mm Hemashield woven graft associated left right coronary artery button  

EPA Pesticide Factsheets

Did you mean: 28 year old woman Patient underwent chemotherapy 5-FU/dip/VCR response. ...... Lid swelling preceded itch eyes redness conjunctive ...... 34-mm Hemashield woven graft associated left right coronary artery button ?

172

28 year old woman Patient underwent chemotherapy 5-FU/dip/VCR response. ...... Lid swelling itch eyes redness conjunctive ...... 34-mm Hemashield woven graft associated left right coronary artery button  

EPA Pesticide Factsheets

Did you mean: 28 year old woman Patient underwent chemotherapy 5-FU/dip/VCR response. ...... Lid swelling itch eyes redness conjunctive ...... 34-mm Hemashield woven graft associated left right coronary artery button ?

173

[Tunnelled internal jugular vein catheters with taurolidine lock: an acceptable challenge to arterio-venous fistula in 70 years old haemodialyzed patients: a prospective pilot study].  

PubMed

Arteriovenous fistula (AVF) is still in 2010 the gold standard of vascular(2) access in haemodialysis (HD) patients. Nevertheless it may be difficult to obtain and/or to use AVF in elderly. With this prospective randomised pilot study, we compare two strategies of vascular access in 70 years old or more new HD patients. AVF were compared to tunnelled jugular vein catheters (TIJC) with taurolidine as bacterial lock solution. Results were as follow: [table: see text] The responses with the visual analogic scale of comfort was 8/10 for TIJC and 5/10 with AVF * P<0.05. In five TIJC patients, heparin was added with success to taurolidine because of partial clotting of catheters. Albuminemia was significantly lower in AVF failure patients compared to AVF success patients (24.8g/L vs 31.1g/L). This pilot study allows to conclude that TIJC is an acceptable challenge to AVF in haemodialysed patients of 70 years or more in a two years long use. PMID:21601549

Branger, Bernard; Reboul, Pascal; Prelipcean, Camélia; Noguera, Maria Eugenia; Cariou, Sylvain; Granolleras, Céline; Vecina, Frédérique; Zabadani, Bachir; Boubenider, Samir; Rousseau, Philippe; Deshodt, Gérard; Ramperez, Pierre; Hory, Bernard; Picard, Eric; Branchereau, Pascal; Fabbro-Peray, Pascale; Fourcade, Jacques

2011-07-01

174

Unintended Harm and Benefit of the Implantable Defibrillator in an Unfortunate 19-Year-Old Male: Featuring a Sequence of Rare Life-threatening Complications of Cardiac Procedures  

PubMed Central

All procedures have inherent risk. Our patient endured a sequence of rare life-threatening complications from commonly preformed procedures. The sequence of these complications was; large pericardial effusion post implantable cardioverter-defibrillator (ICD) implantation with echocardiographic signs of tamponade, left main narrowing post radiofrequency ablation, and late stent thrombosis post coronary intervention with a bare metal stent. All these occurred to one unfortunate young man. Furthermore, our patient demonstrated an unintended benefit of ICD which saved his life.

Daoulah, Amin; Ocheltree, Ali; Lotfi, Amir; Ocheltree, Sara; Alsheikh-Ali, Alawi A; Al-Habib, Abdul-Karim; El-Sayed, Osama; Haneef, Ali

2013-01-01

175

A quantitative study on the condom-use behaviors of eighteen- to twenty-four-year-old urban African American males.  

PubMed

This research study sought to develop, pilot test, and assess a brief male-centered condom promotion program for urban young adult African American males. For study implementation, both qualitative and quantitative research methods were used, and the project was guided by tenets of two common but integrated theoretical frameworks in HIV/sexually transmitted disease (STD) prevention research: the social cognitive theory and the stages of change model. The purpose of the qualitative component was to identify and explore condom-use barriers and facilitators while that of the quantitative component was to identify the prevalence of condom-related behaviors and the feasibility of program administration. After recruitment of study participants from hang-out spots and street intercepts, study participants were self-administered a baseline survey regarding their perceived condom-use behaviors prior to random assignment to program conditions (a condom promotion program and an attention-matched comparison condition). In this paper, we report the findings from the analyses of the quantitative baseline survey data. While the occurrence of HIV/STD-related risk behavIors were highly prevalent among this population; importantly, regression analyses revealed that sexual debut, favorable attitudes toward condom use, social or personal connectedness to HIV/STDs, health beliefs, perceived susceptibility, unprotected sexual encounters, and refusal skills were predictive of retrospective (i.e., prior 30 days) condom use while positive reasons (pros) to use condoms, condom-use beliefs, condom-carrying, health belief, unprotected sexual encounters and refusal skills were also predictive of prospective (i.e., future 30 days) condom-use intentions. The implications and limitations of this study are described and recommendations provided for program development. PMID:17518523

Kennedy, Stephen B; Nolen, Sherry; Applewhite, Jeffrey; Pan, Zhenfeng; Shamblen, Stephen; Vanderhoff, Kenneth J

2007-05-01

176

A Quantitative Study on the Condom-Use Behaviors of Eighteen- to Twenty-Four-Year-Old Urban African American Males  

PubMed Central

This research study sought to develop, pilot test, and assess a brief male-centered condom promotion program for urban young adult African American males. For study implementation, both qualitative and quantitative research methods were used, and the project was guided by tenets of two common but integrated theoretical frameworks in HIV/sexually transmitted disease (STD) prevention research: the social cognitive theory and the stages of change model. The purpose of the qualitative component was to identify and explore condom-use barriers and facilitators while that of the quantitative component was to identify the prevalence of condom-related behaviors and the feasibility of program administration. After recruitment of study participants from hang-out spots and street intercepts, study participants were self-administered a baseline survey regarding their perceived condom-use behaviors prior to random assignment to program conditions (a condom promotion program and an attention-matched comparison condition). In this paper, we report the findings from the analyses of the quantitative baseline survey data. While the occurrence of HIV/STD-related risk behaviors were highly prevalent among this population; importantly, regression analyses revealed that sexual debut, favorable attitudes toward condom use, social or personal connectedness to HIV/STDs, health beliefs, perceived susceptibility, unprotected sexual encounters, and refusal skills were predictive of retrospective (i.e., prior 30 days) condom use while positive reasons (pros) to use condoms, condom-use beliefs, condom-carrying, health belief, unprotected sexual encounters and refusal skills were also predictive of prospective (i.e., future 30 days) condom-use intentions. The implications and limitations of this study are described and recommendations provided for program development.

KENNEDY, STEPHEN B.; NOLEN, SHERRY; APPLEWHITE, JEFFREY; PAN, ZHENFENG; SHAMBLEN, STEPHEN; VANDERHOFF, KENNETH J.

2007-01-01

177

Multiple endocrine neoplasia type 2a and germ line C634G RET mutation diagnosed in an 80-year-old patient.  

PubMed

An 80-year-old man presented with progressive fatigue. Blood tests showed that serum calcium was increased (2.93 mmol/l, normal range 2.20-2.55 mmol/l) and serum concentration of intact parathyroid hormone (iPTH) inappropriately high (198 pg/ml, normal range 15-85 pg/ml). Neck ultrasonography and Tc-MIBI scintigraphy revealed a right parathyroid adenoma and a multinodular goiter. Serum calcitonin was significantly increased (220 pg/ml, normal range<10 pg/ml). Concomitantly, a chest-abdominal computed tomography was performed and revealed a 22 mm right adrenal incidentaloma. The urinary catecholamines and metabolites were two-fold above the upper limit of normal. After right adrenalectomy which confirmed the diagnosis of pheochromocytoma, the patient underwent total thyroidectomy with dissection of the central lymph node compartment and right parathyroidectomy. On histopathologic examination, both thyroid lobes presented 13 foci of MTC without lymph node metastasis and the parathyroid gland presented a benign adenoma without hyperplasia. The patient underwent screening and genetic testing revealing a germ line C634 G RET mutation. The diagnosis of Men2a at the age of 80 years and the absence of lymph node metastasis of the multiple MTC in a carrier of C634G mutation were unusual and argued for the possible role of genetic modifier(s) in this MEN 2a patient. PMID:19201392

Sanz, C; Vezzosi, D; Pigny, P; Bennet, A; Caron, P

2009-04-01

178

Combination of acupuncture and spinal manipulative therapy: management of a 32-year-old patient with chronic tension-type headache and migraine  

PubMed Central

Objective The purpose of this case study is to describe the treatment using acupuncture and spinal manipulation for a patient with a chronic tension-type headache and episodic migraines. Clinical Features A 32-year-old woman presented with headaches of 5 months' duration. She had a history of episodic migraine that began in her teens and had been controlled with medication. She had stopped taking the prescription medications because of gastrointestinal symptoms. A neurologist diagnosed her with mixed headaches, some migrainous and some tension type. Her headaches were chronic, were daily, and fit the International Classification of Headache Disorders criteria of a chronic tension-type headache superimposed with migraine. Intervention and Outcome After 5 treatments over a 2-week period (the first using acupuncture only, the next 3 using acupuncture and chiropractic spinal manipulative therapy), her headaches resolved. The patient had no recurrences of headaches in her 1-year follow-up. Conclusion The combination of acupuncture with chiropractic spinal manipulative therapy was a reasonable alternative in treating this patient's chronic tension-type headaches superimposed with migraine.

Ohlsen, Bahia A.

2012-01-01

179

Successful treatment of a 14-year-old patient with intestinal malrotation with laparoscopic Ladd procedure: case report and literature review  

PubMed Central

Midgut malrotation is an anomaly of intestinal rotation that occurs during fetal development and usually presents in the neonatal period. We present a rare case of malrotation in a 14-year-old patient who presented with cramping, generalized right abdominal pain, and vomiting for a duration of one day. A computed tomography abdominal scan and upper gastrointestinal contrast studies showed malrotation of the small bowel without volvulus. Laparoscopy revealed typical Ladd’s bands and a distended flabby third and fourth duodenal portion extrinsically obstructing the misplaced duodeno-jejunal junction. The Ladd procedure, including widening of the mesenteric base and appendectomy, was performed. Symptoms completely resolved in a half-year follow up period. Patients with midgut malrotation may present with vague abdominal pain, intestinal obstruction, or intestinal ischemia. The laparoscopic Ladd procedure is feasible and safe, and it appears to be as effective as the standard open Ladd procedure in the diagnosis and treatment of teenage or adult patients with intestinal malrotation.

2013-01-01

180

Risk factors for bone mineral density at the calcaneus in 40-59 year-old male workers: A cross-sectional study in Korea  

PubMed Central

Background Few epidemiologic studies have attempted to investigate the prevalence and risk factors for osteopenia and osteoporosis in middle-aged Asian men. We performed this study to determine the prevalence and risk factors of osteopenia and osteoporosis in this population. Methods This cross-sectional study was conducted from March to July, 2004. The subjects were 2,073 males aged from 40 to 59 years in the KHNP (Korea Hydro & Nuclear Power) workplace-based cohort. Bone mineral density (BMD) was measured by peripheral, dual-energy, X-ray absorptiometry (DXA) at the calcaneus. Anthropometric and lifestyle factors were investigated using a standard, self-reported questionnaire. Results BMD was 0.60 ± 0.09 g/cm2 (mean ± standard deviation) and was negatively correlated with age (r = -0.18, P < 0.001), but positively correlated with waist-to-hip ratio (WHR; r = 0.15, P < 0.001), body fat (r = 0.10, P < 0.001), BMI (r = 0.35, P < 0.001), height (r = 0.26, P < 0.001), and weight (r = 0.43, P < 0.001). In multiple linear regression analysis, the independent determinants associated with BMD were increasing age (coefficient = -0.002, P < 0.001), physical activity (? 2/week vs. ? 3/week; coefficient = 0.017, P < 0.001), WHR (coefficient = -0.796, P < 0.001), body mass index (BMI; coefficient = 0.023, P < 0.001) and smoking status (never vs. ever; coefficient = -0.018, P < 0.001). Conclusion We suggest that BMD of the calcaneus is correlated negatively with exposure to smoke and increased WHR, but positively with regular exercise and increased BMI.

Seo, Hyun-Ju; Kim, Soo-Geun; Kim, Chong-Soon

2008-01-01

181

Electroconvulsive Therapy for Treatment of Major Depression in a 100-Year-Old Patient with Severe Aortic Stenosis: A 5-year follow up report  

PubMed Central

Although there is no specific age cut-off for ECT and no absolute contraindication to its use, very old age as well as the presence of cardiac conditions such as aortic stenosis are factors that may negatively impact the clinician's decision to administer ECT in the individual case. We report our follow-up of a 100 year old female with severe aortic stenosis who has now received ECT safely for a period of 5 years. No cardiac complications have emerged during this period. Her prior unipolar depressive episode with catatonic features remains in remission with a single prophylactic ECT session every 3 months. We have observed from our experience with this unique case that periodic multidisciplinary re-evaluation of the evolving risk-benefit profile of ECT is essential along with the inclusion of family members in this dialogue. Our patient course illustrates that neither advanced age nor severe aortic stenosis are absolute contraindications to ECT even over an extended period of time. Each case needs to be evaluated on its merits. To our knowledge, this case represents the oldest patient in the literature where ECT has been administered safely for such an extended period in the setting of severe aortic stenosis.

O'Reardon, John P.; Cristancho, Mario A.; Ryley, Barbara; Patel, Kajal R.; Haber, Howard L.

2011-01-01

182

A 44-year-old patient with a new-onset seizure disorder after vaccination against Japanese encephalitis: a case report  

PubMed Central

Introduction Seizure disorders can have a wide variety of causes. In many cases, however, the underlying cause remains unknown. Vaccinations, for example, can trigger seizures, especially during childhood. In the literature, many cases have been reported in which febrile convulsions occurred after the administration of different types of vaccines, such as the measles, mumps and rubella vaccine or the tetanus and diphtheria vaccine. Only a few cases of epilepsy after vaccination have thus far been described in adults. Case presentation In the case reported here, a 44-year-old German Caucasian man working as a soldier had a seizure the day after he received a third dose of Japanese encephalitis vaccine. Before this vaccination, he had received multiple vaccines that he had tolerated well. He underwent several drug therapies at various institutions but has continued to experience different forms of seizures for more than 18 months. The intervals between seizures were approximately six weeks in length. The present work discusses our patient’s history, including all diagnostic procedures and results, as well as treatment approaches. None of the examinations revealed a possible cause for the seizures. Since no structural or genetic causes were detected, the seizures were deemed most likely to have been caused by the vaccinations, especially vaccination against Japanese encephalitis. To date, no medication has prevented our patient from having repeated attacks. Conclusions To the best of our knowledge there have been no previous cases reported in the literature where seizures occurred after multiple vaccinations in general or after vaccinations against Japanese encephalitis in particular. Although vaccines are tested before release, the appearance of new adverse reactions cannot be prevented in all cases. Seizure after vaccination is difficult to treat. In our patient’s case, different approaches have not led to a satisfying result to date.

2013-01-01

183

"Apraxic dysgraphia" in a 15-year-old left-handed patient: disruption of the cerebello-cerebral network involved in the planning and execution of graphomotor movements.  

PubMed

Apraxic agraphia is a peripheral writing disorder caused by neurological damage. It induces a lack or loss of access to the motor engrams that plan and programme the graphomotor movements necessary to produce written output. The neural network subserving handwriting includes the superior parietal region, the dorsolateral and medial premotor cortex and the thalamus of the dominant hemisphere. Recent studies indicate that the cerebellum may be involved as well. To the best of our knowledge, apraxic agraphia has not been described on a developmental basis. This paper reports the clinical, neurocognitive and (functional) neuroimaging findings of a 15-year-old left-handed patient with an isolated, non-progressive developmental handwriting disorder consistent with a diagnosis of "apraxic dysgraphia". Gross motor coordination problems were objectified as well but no signs of cerebellar, sensorimotor or extrapyramidal dysfunction of the writing limb were found to explain the apraxic phenomena. Brain MRI revealed no supra- and infratentorial damage but quantified Tc-99m-ECD SPECT disclosed decreased perfusion in the anatomoclinically suspected prefrontal and cerebellar brain regions crucially involved in the planning and execution of skilled motor actions. This pattern of functional depression seems to support the hypothesis that "apraxic dysgraphia" might reflect incomplete maturation of the cerebello-cerebral network involved in handwriting. In addition, it is hypothesized that "apraxic dysgraphia" may have to be considered to represent a distinct nosological category within the group of the developmental dyspraxias following dysfunction of the cerebello-cerebral network involved in planned actions. PMID:22752975

Mariën, Peter; de Smet, Eric; de Smet, Hyo Jung; Wackenier, Peggy; Dobbeleir, Andre; Verhoeven, Jo

2013-02-01

184

Acute lower respiratory infections in >=5 year -old hospitalized patients in Cambodia, a low-income tropical country: clinical characteristics and pathogenic etiology  

PubMed Central

Background Few data exist on viral and bacterial etiology of acute lower respiratory infections (ALRI) in ?5 yearold persons in the tropics. Methods We conducted active surveillance of community-acquired ALRI in two hospitals in Cambodia, a low-income tropical country. Patients were tested for acid-fast bacilli (AFB) by direct sputum examination, other bacteria by blood and/or sputum cultures, and respiratory viruses using molecular techniques on nasopharyngeal/throat swabs. Pulmonologists reviewed clinical/laboratory data and interpreted chest X-rays (CXR) to confirm ALRI. Results Between April 2007 - December 2009, 1,904 patients aged ?5 years were admitted with acute pneumonia (50.4%), lung sequelae-associated ALRI (24.3%), isolated pleural effusions (8.9%) or normal CXR-related ALRI (17.1%); 61 (3.2%) died during hospitalization. The two former diagnoses were predominantly due to bacterial etiologies while viral detection was more frequent in the two latter diagnoses. AFB-positive accounted for 25.6% of acute pneumonia. Of the positive cultures (16.8%), abscess-prone Gram-negative bacteria (39.6%) and Haemophilus influenzae (38.0%) were most frequent, followed by Streptococcus pneumoniae (17.7%). Of the identified viruses, the three most common viruses included rhinoviruses (49.5%), respiratory syncytial virus (17.7%) and influenza viruses (12.1%) regardless of the diagnostic groups. Wheezing was associated with viral identification (31.9% vs. 13.8%, p?patients with acute pneumonia, requiring further investigation. The relationship between respiratory viruses and wheezing merits further studies.

2013-01-01

185

mRNA transfection-based, feeder-free, induced pluripotent stem cells derived from adipose tissue of a 50-year-old patient.  

PubMed

Induced pluripotent stem cells (iPSC) have successfully been derived from somatic fibroblasts through transfection of synthetic modified mRNA encoding transcription factors. This technique obviates the use of recombinant DNA and viral vectors in cellular reprogramming. The present study derived iPSC from adipose-derived mesenchymal stem cells (of a 50-year-old female patient) by utilizing a similar technique, but with defined culture medium without feeder cells, during both reprogramming and propagation. Clonal selection was performed to yield 12 putative iPSC lines from individual colonies of nascent reprogrammed cells, starting from 150,000 cells. However, only seven lines maintained their undifferentiated state after 10 continuous serial passages. These seven lines were then subjected to a rigorous battery of analyses to confirm their identity as iPSC. These tests included immunostaining, flow cytometry, qRT-PCR, in vitro differentiation assay, and teratoma formation assay within SCID mice. Positive results were consistently observed in all analyses, thus verifying the cells as fully reprogrammed iPSC. While all 7 iPSC lines displayed normal karyogram up to passage 13, chromosomal anomalies occurred in 4 of 7 lines with extended in vitro culture beyond 24 serial passages. Only three lines retained normal karyotype of 46,XX. The remaining four lines displayed mosaicism of normal and abnormal karyotypes. Hence, this study successfully derived iPSC from abundant and easily accessible adipose tissues of a middle-aged patient; utilizing a mRNA-based integration-free technique under feeder-free conditions. This is a step forward in translating iPSC into personalized regenerative medicine within the clinic. PMID:23542141

Heng, Boon Chin; Heinimann, Karl; Miny, Peter; Iezzi, Giandomenica; Glatz, Katharina; Scherberich, Arnaud; Zulewski, Henryk; Fussenegger, Martin

2013-07-01

186

Vagus nerve stimulation in children less than 5 years old  

Microsoft Academic Search

Introduction  Vagus nerve stimulation (VNS) has been used in both adults and older children with varying success.Materials and methods  We retrospectively reviewed our experience with VNS in very young children (below 5 years old). The mean age at stimulator implantation was 20.5 months. Two patients were below 2 years old at implantation and two patients were below 1 year old at their initial surgery. The average

Jeffrey P. Blount; R. Shane Tubbs; Pongkiat Kankirawatana; Sarah Kiel; Robert Knowlton; Paul A. Grabb; Martina Bebin

2006-01-01

187

Giant coronary artery aneurysms in a 58-year-old.  

PubMed

All giant Kawasaki aneurysms may not regress fully; some may eventually calcify, undergo thrombosis, and get detected in asymptomatic adults at later age. Tomisaku Kawasaki initially described this illness as mucocutaneous lymph node syndrome in childhood in 1967 and coronary arteritis was recognized later. We present a 58-year-old male, possibly one of the oldest surviving patients with giant coronary aneurysms who presented with large secundum atrial septal defect (ASD) with heart failure. This indicates that the disease was perhaps prevalent outside Japan even before the first Kawasaki's description. PMID:24987266

Singhi, Anil Kumar; Pavithran, Sreeja; Sivakumar, Kothandam

2014-05-01

188

Giant coronary artery aneurysms in a 58-year-old  

PubMed Central

All giant Kawasaki aneurysms may not regress fully; some may eventually calcify, undergo thrombosis, and get detected in asymptomatic adults at later age. Tomisaku Kawasaki initially described this illness as mucocutaneous lymph node syndrome in childhood in 1967 and coronary arteritis was recognized later. We present a 58-year-old male, possibly one of the oldest surviving patients with giant coronary aneurysms who presented with large secundum atrial septal defect (ASD) with heart failure. This indicates that the disease was perhaps prevalent outside Japan even before the first Kawasaki's description.

Singhi, Anil Kumar; Pavithran, Sreeja; Sivakumar, Kothandam

2014-01-01

189

Hobnail hemangioma in a nine-year-old boy: a rare case presented with dermoscopy.  

PubMed

Hobnail hemangioma is a benign vascular tumor that typically occurs on the trunk and extremities. Most patients present in the 20s and 30s. We describe a rare case of hobnail hemangioma in a 9-year-old male. PMID:20409414

Ibrahim, Marian; Shwayder, Tor

2010-01-01

190

Systemic mastocytosis accompanied by a non-secretory plasma cell dyscrasia and nephrotic syndrome-level proteinuria in a 76-year-old patient.  

PubMed

We report here the interesting case of a 76-year-old man with severe proteinuria who was diagnosed with systemic mastocytosis accompanied by a clonal non-mast-cell lineage haematological disorder (a non-secretory plasma cell dyscrasia). This is a unique report of systemic mastocytosis with a non-secretory plasma cell dyscrasia and nephrotic syndrome. The pathophysiological relevance between these entities along with the probability of occult amyloidosis is discussed. PMID:24081151

Papadopoulou, Vasiliki; Ioannou, Savvas; Levidou, Georgia; Variami, Eleni; Kouzis, Panagiotis; Siakantaris, Marina

2014-01-01

191

Bilateral Ectopic Hypoplastic Uteri Attached to Bilateral Pelvic Sidewalls in a 21-Year-Old Patient with Primary Amenorrhea: The First Published Report  

PubMed Central

Müllerian duct anomalies (MDAs) encompass a group of anatomical malformations resulting from defective development, fusion, migration, or resorption of Müllerian (paramesonephric) ducts during embryonic life. Herein, we report the first case of an exceedingly uncommon MDA (bilateral ectopic hypoplastic uteri attached to bilateral pelvic sidewalls) in a 21-year-old woman who was referred to our tertiary care center as a case of primary amenorrhea for workup and further management.

Nazer, Ahmed; AlOmar, Osama; Salem, Hany; Al-Badawi, Ismail A.

2013-01-01

192

Cerebral amyloid angiopathy with co-localization of prion protein and beta-amyloid in an 85-year-old patient with sporadic Creutzfeldt–Jakob disease  

Microsoft Academic Search

We report on an 85-year-old woman with hypertensive cerebral arteriolosclerosis who presented with rapidly progressive encephalopathy\\u000a leading to death within 4 months. Magnetic resonance imaging showed mild cortical atrophy consistent with her age and diffuse\\u000a leukoaraiosis. Her CSF 14–3–3 protein was positive. Neuropathology showed severe spongiform change and gliosis in the grey\\u000a matter and immunohistochemistry revealed diffuse prion protein deposition in

Claire Paquet; Nicolas Privat; Rachid Kaci; Marc Polivka; Olivier Dupont; Stéphane Haïk; Jean Louis Laplanche; Jean Jacques Hauw; Françoise Gray

2008-01-01

193

Bilateral ectopic hypoplastic uteri attached to bilateral pelvic sidewalls in a 21-year-old patient with primary amenorrhea: the first published report.  

PubMed

Müllerian duct anomalies (MDAs) encompass a group of anatomical malformations resulting from defective development, fusion, migration, or resorption of Müllerian (paramesonephric) ducts during embryonic life. Herein, we report the first case of an exceedingly uncommon MDA (bilateral ectopic hypoplastic uteri attached to bilateral pelvic sidewalls) in a 21-year-old woman who was referred to our tertiary care center as a case of primary amenorrhea for workup and further management. PMID:24288635

Nazer, Ahmed; Abu-Zaid, Ahmed; Alomar, Osama; Salem, Hany; Azzam, Ayman; Al-Badawi, Ismail A

2013-01-01

194

Long-term neurodevelopmental effects of early detection and treatment in a 6-year-old patient with argininaemia diagnosed by newborn screening  

Microsoft Academic Search

Summary  Newborn screening makes possible the early identification and treatment of asymptomatic ARG1-deficient patients; however,\\u000a it is unknown whether early intervention prevents neurological insults. We identified a full-term Hispanic male infant with\\u000a argininaemia by newborn screening with a serum arginine of 327 µmol\\/L (reference values 0–140); ARG1 was undetectable on enzyme\\u000a assay. Sequence analysis of ARG1 revealed a heterozygous nonsense mutation, c.223A>T

R. L. Edwards; K. Moseley; Y. Watanabe; L. J. Wong; J. Ottina; S. Yano

195

3-D printout of a DICOM file to aid surgical planning in a 6 year old patient with a large scapular osteochondroma complicating congenital diaphyseal aclasia.  

PubMed

A 6 year old girl presented with a large osteochondroma arising from the scapula. Radiographs, CT and MRI were performed to assess the lesion and to determine whether the lesion could be safely resected. A model of the scapula was created by post-processing the DICOM file and using a 3-D printer. The CT images were segmented and the images were then manually edited using a graphics tablet, and then an STL-file was generated and a 3-D plaster model printed. The model allowed better anatomical understanding of the lesion and helped plan surgical management. PMID:22690278

Tam, Matthew D; Laycock, Stephen D; Bell, Duncan; Chojnowski, Adrian

2012-01-01

196

Umbilical cord blood transplantation in hematologic diseases in patients over 15 years old: long-term experience at the Pontificia Universidad Católica de Chile.  

PubMed

Most patients who require a sibling stem cell transplantation do not have a matched donor. In our experience, only 1/3 patients have a matched unrelated donor (MUD); therefore, the majority of the patients will require umbilical cord blood (UCB). Patients treated for hematologic diseases with UCB transplants were included. UCB selection and conditioning regimens were performed according to the Minnesota group. Graft-versus-host disease (GVHD) prophylaxis, infection prevention, and patient care were performed according to institutional guidelines. We analyzed patients and graft demography, neutrophil and platelet recovery, chimerism kinetics, GVHD incidence, overall (OS), progression-free survival (PFS) and transplant-related mortality (TRM). We included 29 patients with a median age of 34.8 years (range 15-55). Eighteen were male and the median weight was 72.6 kg (range 54-100). Nineteen patients had acute leukemia. Myeloablative (MA) conditioning was used in 27 patients. Seventeen received double UCB (DUCB) grafts. Median total nucleated cell (10(7)/kg) was 4.2 (range 3.9-4.9) and 4.4 (range 2.8-6.3) for single UCB (SUCB) and DUCB transplants, respectively. Median time for neutrophil engraftment was 24.7 (range 14-43) and 25.8 days (range 14-52) after SUCB and DUCB transplants, respectively. Median time for platelet engraftment was 147 (range 30-516) and 81 days (range 37-200) after SUCB and DUCB transplants, respectively. All the patients receiving MA conditioning had >95% chimerism shortly after transplant. Cumulative incidence of grades II-IV and III-IV acute GVHD was 41% and 20%, respectively. Localized chronic GVHD was seen in 14% of the patients. Median follow-up was 16.7 months (range 1-63). Five-year OS and PFS were 38% and 39%, respectively. One-year TRM was 42%. UCB transplantation is associated with potential cure of hematologic malignancies and our results are similar to other series. Studies are needed to decrease mortality and improve immune reconstitution. PMID:24315012

Ramirez, P; Nervi, B; Bertin, P; Poggi, H; Lagos, M; Selman, C; Pizarro, I; Jara, V; Wiestruck, A; Barriga, F

2013-12-01

197

Parotid sialolithiasis in a two-year-old boy  

PubMed Central

Sialolithiasis is caused by the obstruction of a salivary gland or its excretory duct by the formation of calcareous concretions or sialoliths; this results in salivary ectasia and provokes subsequent dilation of the salivary gland. Sialolithiasis is relatively common, accounting for 30% of salivary diseases; however, it is rarely observed in childhood. This case report describes a 2-year-old male patient who complained of a painful swelling over the right cheek, and presented with palpable stones and pus discharge from the orifice of the right Stensen's duct. Computerized tomography of the neck confirmed the diagnosis, and the patient received intravenous empiric antibiotics combined with intraoral sialolithotomy. We also provide a review of the spectrum of concepts regarding the pathogenesis, diagnosis, and treatment of sialolithiasis.

Kim, Do Hoon; Song, Woo Sun; Kim, Yeong Jin

2013-01-01

198

Unilateral renal agenesis with absent ductus deferens, epididymis and seminal vesicle: incidental finding in a 22-year-old patient with maldevelopment of the mesonephric duct.  

PubMed

Unilateral renal agenesis with an absence of the seminal vesicle, epididymis and ductus deferens is rare and is the result of a developmental disorder of the mesonephric or Wolffian duct. We report the case of a 22-year-old man who presented with testicular pain on the left side of 3 weeks' duration. During the clinical investigation of the scrotum a nonpalpable ductus deferens on the left side was found incidentally. As a result of the urological ultrasound the diagnosis of renal, epididymal, seminal vesicle and ductus deferens agenesis on the left was confirmed. As a vascular variety the CT demonstrated 2 renal veins and 2 renal arteries on the right originating from the superior mesenteric artery together with the right hepatic artery. The testicular artery was placed on both sides. Further diagnostic investigations including a spermiogram, hormone analysis and kidney function tests were normal. Congenital urogenital malformations can be found in various combinations even in adults. Unilateral absence of the vas deferens during clinical examination should alert the clinician to an underlying renal, seminal vesicle and epididymal anomaly; further urological investigation is mandatory. A genetic investigation of the CFTR gene is not necessary in the absence of both ductus deferentes with renal agenesis. PMID:21160165

Pichler, Renate; Oswald, Josef; Glodny, Bernhard; Skradski, Viktor; Aigner, Friedrich; Rehder, Peter

2011-01-01

199

Form and Functions of "Slut Bashing" in Male Identity Constructions in 15-Year-Olds: "I Know It May Sound Mean to Say This, but We Couldn't Really Care Less about Her Anyway"  

ERIC Educational Resources Information Center

In this article I discuss an excerpt from a group discussion between five 15-year-old boys who, in the presence of an adult moderator, engaged in the act of "slut bashing" while telling a minimal story about an incident of female promiscuity. The analysis proceeds microanalytically in a three-step procedure that details the positions taken by the…

Bamberg, Michael

2004-01-01

200

Hepatic adenomas in male patients  

PubMed Central

Background Hepatic adenomas are benign tumours of the liver most commonly seen in premenopausal women. However, it is now clear that adenomas may occur in males. This small series reviews the characteristics of hepatic adenomas in males. Case outlines Three cases of solitary hepatic adenoma occurring in otherwise well male patients (age 22–48 years) are presented. Two patients presented with abnormal liver function tests while one presented with abdominal pain. Imaging of the lesions demonstrated typical appearances of hepatocellular adenoma, resection was undertaken in all cases and all patients remain alive and well. Discussion Up to 20% of adenomas are documented as occurring in male patients. Most are solitary and occur in patients without recognised risk factors (steroid therapy and glycogen storage diseases types I and III). However, multiple adenomas are most commonly seen in male patients with risk factors. The imaging characteristics and presentation of adenomas in males are similar to female patients and, most importantly, intraperitoneal rupture and malignant transformation are documented in untreated adenomas in males.

Ronald, M; Woodfield, J; McCall, J

2004-01-01

201

Two-Years-Old Social Competence.  

ERIC Educational Resources Information Center

This guide for parents discusses social competence in 2-year-old children, drawing upon anecdotal data to provide a sampling of 2-year-old children's social behavior and their parents' child rearing techniques. The data were collected from questionnaires, telephone interviews, and home visits in a 12-month study of the interactions of 86…

Adcock, Don; Segal, Marilyn

202

How Grammatical Are 3-Year-Olds?  

ERIC Educational Resources Information Center

Purpose: This study investigated the level of grammatical accuracy in typically developing 3-year-olds and the types of errors they produce. Method: Twenty-two 3-year-olds participated in a picture description task. The percentage of grammatical utterances was computed and error types were analyzed. Results: The mean level of grammatical accuracy…

Eisenberg, Sarita L.; Guo, Ling-Yu; Germezia, Mor

2012-01-01

203

Recurrent hemoptysis in a 62-year-old smoker.  

PubMed

Tracheal papillary adenoma is a rare benign tumor. We report a case of papillary adenoma in a 62-year-old male smoker who presented with recurrent hemoptysis. The tumor was located in the upper third of trachea and forceps biopsy through flexible bronchoscopy was uncomplicated and diagnostic. PMID:23741099

Gowrinath, Karanam; Ramakrishna, Baddukonda Appala; Shanthi, Vissa; Sujatha, Gogineni

2013-04-01

204

Recurrent hemoptysis in a 62-year-old smoker  

PubMed Central

Tracheal papillary adenoma is a rare benign tumor. We report a case of papillary adenoma in a 62-year-old male smoker who presented with recurrent hemoptysis. The tumor was located in the upper third of trachea and forceps biopsy through flexible bronchoscopy was uncomplicated and diagnostic.

Gowrinath, Karanam; Ramakrishna, Baddukonda Appala; Shanthi, Vissa; Sujatha, Gogineni

2013-01-01

205

Multifocal epithelioid hemangioendothelioma in a 16-year-old boy  

Microsoft Academic Search

We report on a 16-year-old white male presenting with a 4-month history of syncopal episodes and occasional headaches. The CT and MRI studies revealed numerous lytic lesions of the skull base and cervical spine; subsequently, similar lesions were demonstrated in all areas of the skeleton, and CT showed numerous lesions in the lungs, liver, and kidneys. Excisional biopsy from several

Brent Adler; John Naheedy; Nicholas Yeager; Kathleen Nicol; Jan Klamar

2005-01-01

206

Fatal Case of Brucellosis Misdiagnosed in Early Stages of Brucella suis Infection in a 46-Year-Old Patient with Marfan Syndrome  

PubMed Central

We report a fatal case of Brucella suis endocarditis initially misdiagnosed by automated identification systems as Ochrobactrum anthropi infection in a patient with a history of Marfan syndrome and recreational feral swine hunting. This report emphasizes the need to consider brucellosis as a part of the differential diagnosis of acute febrile illness, particularly in patients with known risk of exposure.

Carrington, M.; Choe, U.; Ubillos, S.; Stanek, D.; Campbell, M.; Wansbrough, L.; Lee, P.; Churchwell, G.; Rosas, K.; Zaki, S. R.; Drew, C.; Paddock, C. D.; DeLeon-Carnes, M.; Guerra, M.; Hoffmaster, A. R.; Tiller, R. V.

2012-01-01

207

Adenocarcinoma of the lung presenting as a diffuse interstitial process in a 25-year-old man  

Microsoft Academic Search

Adenocarcinoma of the lung is rare in young adults, particularly in persons below the age of 30. Younger patients tend to present with advanced stages of carcinoma, and often have a rapidly deteriorating course. We describe a 25-year-old male who presented with diffuse interstitial lung disease which was found at autopsy to be lymphangitic carcinomatosis of probable pulmonary origin.

Douglas W. Mapel; Richard H. Fei; Richard E. Crowell

1996-01-01

208

Adenocarcinoma at the ureterosigmoidostomy site in a 16-year-old demonstrates the importance of screening in children  

Microsoft Academic Search

We report the death of a 17-year-old male exstrophy patient from adenocarcinoma arising at the ureterosigmoidostomy. This was detected at reconstructive surgery at the age of 16 years, 13 years after ureterosigmoidostomy. This case highlights the importance of including children in endoscopic surveillance. We recommend annual sigmoid–colonoscopy commencing 10 years after ureterosigmoidostomy irrespective of age.

Naima Smeulders; Nada Sudhakaran; Duncan T. Wilcox; Philip G. Ransley

2008-01-01

209

Cemented revision total hip arthroplasties in patients younger than 55 years old. A multicenter evaluation of second-generation cementing technique.  

PubMed

The results of all cemented first-time revisions in Sweden performed in patients younger than 55 years of age, during the period 1984-1986, are reported. The revisions were performed by the average orthopaedic surgeon in 25 hospitals distributed throughout Sweden. Second-generation femoral cementing technique was used. One third of the acetabular revisions were performed with pressurized cement. The reason for revision was aseptic loosening. Seventy hips in 68 patients were reviewed at an average follow-up period of 7 years (range, 4-10 years). The average age of the patients at the time of revision surgery was 47 years. Forty-eight cups and 57 stems were revised using cement. Survival analysis, with revision for aseptic loosening as the endpoint, suggests an overall 76% survival rate after 8 years. The survival rate for the cup was 80%, and for the stem, 85%. The radiographic evaluation revealed that the cement mantle was inadequate in many revisions. Localized osteolysis was rare. Clinical data were reported for 55 (53 patients) non-revised hips. Thirty-five hips were without pain or slightly painful. Forty patients limped when walking. Forty-three patients were satisfied with the revised hip. These results using second-generation femoral cementing technique are better than those reported with first-generation technique, but the failure rate in this young patient population is too high. The search for a more durable fixation in revision total hip athroplasty for young patients with long life expectancy is ongoing. These results emphasize that there is a need for centralization to gain experience in extended clinical research and to further improve surgical and cementing techniques. PMID:8872565

Strömberg, C N; Herberts, P

1996-08-01

210

Cardiovascular events and geriatric scale scores in elderly (70 years old and above) type 2 diabetic patients at inclusion in the GERODIAB cohort.  

PubMed

OBJECTIVE To analyze the relationships between cardiovascular complications and geriatric scale scores in French elderly (?70 years of age) type 2 diabetic patients at inclusion in the GERODIAB cohort. RESEARCH DESIGN AND METHODS GERODIAB is the first French multicenter, prospective, observational survey designed to analyze the influence of glycemic control on morbidity/mortality in type 2 diabetic patients aged ?70 years during a 5-year follow-up period. This study analyzed the relationships between classical macroangiopathic complications and geriatric scale scores in 987 patients at baseline, using bivariate and multivariate analyses. RESULTS Cardiac ischemia (31.2%) was significantly associated with impaired activities of daily living (ADL) scores (P < 0.001). Stepwise logistic regression included hypercholesterolemia, ADL, sex, and hypertension successively (70.3% concordance; P < 0.001). Heart failure (10.1%) was associated with impaired Mini Mental State Examination (MMSE), instrumental ADL (IADL) (P < 0.05), and ADL scores (P < 0.001). With the logistic model, waist circumference, age, and HDL cholesterol were significant factors (70.7% concordance; P < 0.001). Arterial disease of the lower limbs (25.6%) was associated with impaired IADL and ADL scores (P < 0.001). Significant factors using the logistic model were duration of diabetes, IADL score, hypertension, and sex (62.8% concordance; P < 0.001). Cerebral ischemia (15.8%) was associated with impaired MMSE, Mini Nutritional Assessment, ADL, and IADL scores (P < 0.01). IADL, sex, hypertension, and ADL were included in the logistic model successively (65.6% concordance; P < 0.001). CONCLUSIONS In this specific population, impaired geriatric scale scores were found to be associated with classical macrovascular complications, notably using multivariate analyses. This suggests the benefits of thorough screening and management of cognitive and functional decline in elderly type 2 diabetic patients. PMID:23990512

Bauduceau, Bernard; Doucet, Jean; Le Floch, Jean-Pierre; Verny, Christiane

2014-01-01

211

A common ancestor more than 10,000 years old for patients with R854Q-related type 2N von Willebrand's disease in Italy.  

PubMed

The impaired capacity of von Willebrand factor to carry factor VIII is identified as type 2N von Willebrand's disease. R854Q is the most common type 2N mutation, and almost the only one identified in Italy. This aim of this study was to ascertain whether R854Q mutations in a cohort of Italian patients with type 2N von Willebrand's disease originated from a single event or recurrent events. Thirteen unrelated Italian families were investigated, analyzing the von Willebrand factor gene haplotype associated with the R854Q mutation. A common haplotype emerged in all the families, extending from single nucleotide polymorphisms rs2166902 to rs216293 over 48.2 kb and including five intragenic markers. This haplotype is infrequent in the healthy Italian population (17% versus 100%, P<0.0001) and each genetic marker within the said haplotype is similarly rare. These data strongly suggest a founder effect, with a single R854Q mutation event being the cause of the type 2N von Willebrand's disease in our cohort of patients. Using DMLE+ software and the mathematical model of Bengtsson and Thomson, it was estimated that the R854Q mutation occurred from 10,000 to 40,000 years ago, which is consistent with the short dimension of the haplotype shared by our patients. Together with the fact that the R854Q mutation seems to be limited to Caucasian populations, these findings suggest that a single mutational event took place after human populations moved from Africa towards Europe. PMID:22875612

Casonato, Alessandra; Daidone, Viviana; Barbon, Giovanni; Pontara, Elena; Di Pasquale, Irene; Gallinaro, Lisa; Marullo, Letizia; Bertorelle, Giorgio

2013-01-01

212

A common ancestor more than 10,000 years old for patients with R854Q-related type 2N von Willebrand's disease in Italy  

PubMed Central

The impaired capacity of von Willebrand factor to carry factor VIII is identified as type 2N von Willebrand's disease. R854Q is the most common type 2N mutation, and almost the only one identified in Italy. This aim of this study was to ascertain whether R854Q mutations in a cohort of Italian patients with type 2N von Willebrand's disease originated from a single event or recurrent events. Thirteen unrelated Italian families were investigated, analyzing the von Willebrand factor gene haplotype associated with the R854Q mutation. A common haplotype emerged in all the families, extending from single nucleotide polymorphisms rs2166902 to rs216293 over 48.2 kb and including five intragenic markers. This haplotype is infrequent in the healthy Italian population (17% versus 100%, P<0.0001) and each genetic marker within the said haplotype is similarly rare. These data strongly suggest a founder effect, with a single R854Q mutation event being the cause of the type 2N von Willebrand's disease in our cohort of patients. Using DMLE+ software and the mathematical model of Bengtsson and Thomson, it was estimated that the R854Q mutation occurred from 10,000 to 40,000 years ago, which is consistent with the short dimension of the haplotype shared by our patients. Together with the fact that the R854Q mutation seems to be limited to Caucasian populations, these findings suggest that a single mutational event took place after human populations moved from Africa towards Europe.

Casonato, Alessandra; Daidone, Viviana; Barbon, Giovanni; Pontara, Elena; Di Pasquale, Irene; Gallinaro, Lisa; Marullo, Letizia; Bertorelle, Giorgio

2013-01-01

213

[13-Year old boy with abdominal pain].  

PubMed

A 13-year old boy presents with pain in the lower right abdomen, showing clinical signs of appendicitis. During McBurney' incision an appendix sana was seen. Histologic examination showed penetrating enterobiasis. This was treated with mebendazol. PMID:22551758

Thomassen, Irene; Klinkhamer, Paul J J M; van de Poll, Marcel C G

2012-01-01

214

Calibration of Three Year Old Child Dummies.  

National Technical Information Service (NTIS)

Tests were performed to develop appropriate calibration procedures to measure the dynamic response of a three-year-old dummy using acceleration measurements. The calibration procedure consisted of four parts: Part I Head Impact tests, Part II Chest Impact...

A. R. Bayer R. W. Lum

1978-01-01

215

Primary Vesical Actinomycosis in a 23-Year-Old Man  

PubMed Central

Introduction. Actinomycosis can affect any organ of the body, although cutaneous fistulas are common in actinomycotic infections, and other organs such as the bladder are only rarely involved. Case Presentation. Herein we report and discuss a young male patient with primary vesical actinomycosis. A 23-year-old man was hospitalized complaining of intermittent gross hematuria over a 6-month duration. The patient underwent a cystoscopic examination under general anesthesia; an edematous, hyperemic, wide-based mass, which protruded from the dome of the bladder, was seen and incompletely resected. The histopathological examination of the material showed Actinomyces organisms surrounded by inflammation and a photomicrograph showed the microorganism. After confirmation of bladder actinomycosis, the patient received penicillin. A CT scan of the abdomen and pelvis showed no evidence of the mass at the postoperative 6th month. Cystoscopic examination showed complete healing of the transurethral resection area at the dome of the bladder. Conclusion. In conclusion, we believe that the gold standard treatment for vesical actinomycosis should include the combination of a transurethral resection of the mass and long-term penicillin treatment.

Ziypak, Tevfik; Adanur, Senol; Ozkaya, Fatih; Cal?k, Muhammet; Polat, Ozkan; Ozbey, Isa

2014-01-01

216

A case of planned pregnancy with an interruption in infliximab administration in a 27-year-old female patient with rheumatoid-factor-positive polyarthritis juvenile idiopathic arthritis which improved after restarting infliximab and methotrexate.  

PubMed

We report a 27-year-old case of juvenile idiopathic arthritis (JIA) having been stopped infliximab during pregnancy. She was safely treated by infliximab therapy with premedications for preventing infusin reactions after her delivery, and then improved in the same manner as when she had been treated with infliximab therapy before pregnancy. As a result, it remains unclear whether or not we can use infliximab to control disease activities during pregnancy. In addition, it is also important to clarify whether or not premedications should be used when resuming infliximab treatment in such patients after pregnancy. These problems still remain controversial. More definitive data are needed in order to allow rheumatologists to better select the optimal TNF-alpha inhibitor therapy when treating pregnant JIA patients. PMID:18273538

Nerome, Yasuhito; Imanaka, Hiroyuki; Nonaka, Yukiko; Tsuru, Yumiko; Maeno, Nobuaki; Takezaki, Tomoko; Mori, Hirosumi; Akaike, Harumi; Kubota, Tomohiro; Kawano, Yoshifumi; Takei, Syuji

2008-01-01

217

Mutations of GATA1, FLT3, MLL-partial tandem duplication, NRAS, and RUNX1 genes are not found in a 7-year-old Down syndrome patient with acute myeloid leukemia (FAB-M2) having a good prognosis.  

PubMed

The prognosis of leukemia developed in Down syndrome (DS) patients has improved markedly. Most DS leukemia occurs before 3 years of age and is classified as acute megakaryocytic leukemia (AMKL). Mutations in the GATA1 gene have been found in almost all DS patients with AMKL. In contrast, it has been shown that occurrence of DS acute myeloid leukemia (DS-AML) after 3 years of age may indicate a higher risk for a poor prognosis, but its frequency is very low. Age is one of the significant prognostic indicators in DS-AML. The prognostic factor of gene alterations has not been reported in older DS-AML patients. We here describe the case of a 7-year-old DS boy with AML-M2, who had no history of transient abnormal myelopoiesis or any clinical poor prognostic factors, such as high white blood cell counts or extramedullary infiltration. We molecularly analyzed the GATA1, FLT3, MLL-partial tandem duplication, NRAS, and RUNX1 (previously AML1) genes and did not detect any alterations. The patient has lived for more than 5 years after treatment on the AML99-Down protocol in Japan. This suggests that a patient lacking these genes alterations might belong to a subgroup of older DS-AML patients with good prognosis. Accumulation of more data on older pediatric DS-AML patients is needed. PMID:18068539

Kawamura, Machiko; Kaku, Hidefumi; Taketani, Takeshi; Taki, Tomohiko; Shimada, Akira; Hayashi, Yasuhide

2008-01-01

218

Cystic fibrosis in a 70 year old woman.  

PubMed Central

A 68 year old woman with a lifelong history of chronic bronchitis was diagnosed as having cystic fibrosis. The diagnosis was based on a suggestive family history, steatorrhoea, bronchiectasis with respiratory insufficiency, and very high sweat sodium content. The patient was found to be heterozygous for the delta F 508 gene defect. Images

van Biezen, P; Overbeek, S E; Hilvering, C

1992-01-01

219

Recurrent sinus pericranii in a 14-year-old boy.  

PubMed

A case of symptomatic and recurrent sinus pericranii in a 14-year-old boy is presented. A blood-filled cyst was diagnosed after head trauma. The sinus pericranii was surgically removed. One year later the patient presented with blurred vision, headaches, and recurrence at a different site in the skull. PMID:3652072

Brown, J A; Woldenberg, L; Velasco, M E

1987-01-01

220

Orthodontic treatment need, outcome and residual treatment need in 15- and 20-year-olds.  

PubMed

The aim of the study was to investigate orthodontic treatment need and the outcome of orthodontic treatment in 15-, and 20-year-olds in Jönköping, Sweden, with special reference to residual treatment need. An offer to participate in a clinical investigation was extended to random samples of 130 15-year-olds and 130 20-year-olds. Ninety-six of the 15-year-olds (73.3%; 45 boys and 51 girls) and 82 of the 20-year-olds (62.6%; 47 males and 35 females) accepted and presented for examination The participants filled in a questionnaire and impressions were taken for study models, which were graded according to the ICON index. In all, 39 (40.6%) of the 15-year-olds and 38 (46.3%) of the 20-year-olds had undergone or were currently undergoing orthodontic treatment. Ninety-one per cent of the 15-year-olds and 84% of the 20-year-olds considered that the orthodontic treatment goals had been fully or almost fully attained. Two of the 15-year-olds and two of the 20-year-olds currently wanted orthodontic treatment. This indicates a residual treatment demand of about 2%. PMID:23230810

Bjerklin, Krister; Lindsten, Rune; Tunge, Jannicke Sagevik; Sjövall, Christine

2012-01-01

221

Pathology Case Study: A 42-Year-Old Man with Hip Pain  

NSDL National Science Digital Library

This is a genitourinary pathology case study presented by the University of Pittsburgh Department of Pathology in which a 42-year-old male has hip pain and an elevated PSA. Visitors are given both the microscopic and gross descriptions, including images, and are given the opportunity to diagnose the patient. This is an excellent resource for students in the health sciences to familiarize themselves with using patient history and laboratory results to diagnose. It is also a helpful site for educators to use to introduce or test student learning in genitourinary pathology.

Hakam, Ardeshir; Nine, Jeff S.

2007-08-14

222

An 18-Year-Old Man With Hepatitis B Virus Infection and Hepatoblastoma  

PubMed Central

A young man presented with a large liver mass and positive hepatitis B virus markers. This 18-year-old male has developed ascites, jaundice, high serum alpha fetoprotein (AFP) level, liver mass and portal hypertension, without fever or calcification in the mass. All favored the diagnosis of rapidly, progressive hepatocellular carcinoma, however proven hepatoblastoma in liver biopsy. Hepatoblastoma usually manifests prior to the third year of life, but can rarely be seen in older children or adults. Although HCC rarely can be presented in young patients with HBV infection, but in patients without cirrhosis hepatoblastoma should be considered as the first possible diagnosis.

Mohammadi Bonehi, Seyed Saeid; Vahedi, Homayoon; Saberifiroozi, Mehdi; Vasei, Mohammad; Hashemi Taheri, Amir Pejman

2012-01-01

223

Bucket-handle meniscal tear in a 5-year-old child.  

PubMed

Bucket-handle meniscus tears are a common athletic injury that occur frequently in the adult population but are extremely rare in young children. A 5-year-old male patient presented with left knee pain after a minor fall to the ground. Complaints of pain with full weight-bearing, locking of the joint during walking, a significant limp, 45° flexion contracture of the knee, and an inability to bring the leg into full extension were noted during examination. MRI showed a large bucket-handle medial meniscal tear. The patient made a full recovery after undergoing arthroscopic repair surgery. Level of evidence Case report, Level IV. PMID:22270672

Shea, Kevin G; Archibald-Seiffer, Noah; Kim, Kang Min; Grimm, Nate L

2012-11-01

224

A Rare, Recurrent, De Novo 14q32.2q32.31 Microdeletion of 1.1 Mb in a 20-Year-Old Female Patient with a Maternal UPD(14)-Like Phenotype and Intellectual Disability  

PubMed Central

We present a 20-year-old female patient from Indonesia with intellectual disability (ID), proportionate short stature, motor delay, feeding problems, microcephaly, facial dysmorphism, and precocious puberty who was previously screened normal for conventional karyotyping, fragile X testing, and subtelomeric MLPA analysis. Subsequent genome wide array analysis was performed on DNA from blood and revealed a 1.1?Mb deletion in 14q32.2q32.31 (chr14:100,388,343-101,506,214; hg19). Subsequent carrier testing in the parents by array showed that the deletion had occurred de novo in the patient and that her paternal 14q32 allele was deleted. The deleted region encompasses the DLK1/GTL2 imprinted gene cluster which is consistent with the maternal UPD(14)-like phenotype of the patient. This rare, recurrent microdeletion was recently shown not to be mediated by low copy repeats, but by expanded TGG repeats, flanking the 14q32.2q32.21 deletion boundaries, a novel mechanism of recurrent genomic rearrangement. This is another example how the application of high resolution genome wide testing provides an accurate genetic diagnosis, thereby improving the care for patients and optimizing the counselling for family.

Mundhofir, Farmaditya E. P.; Nillesen, Willy; Faradz, Sultana M. H.

2014-01-01

225

100-Year Old Adobe Building Destroyed  

USGS Multimedia Gallery

A one hundred year old adobe building in Talca, Chile suffered near-total collapse during the M 8.8 earthquake on Feb. 27, 2010. Adobe, which is made of clay, sand and straw, is no longer used as a building material in Chile, but ancient structures are still common and can pose a hazard to their occ...

2010-03-30

226

Thirteen for Thirteen-Year-Olds  

ERIC Educational Resources Information Center

What does it take to reach a middle school reader? Literacy expert Laura Robb recently shared her top strategies in a webcast for Scholastic fans. This article presents Robb's 13 strategies for thirteen-year-olds. These are: (1) Respect students' search for self; (2) Embrace blogging; (3) Send texts in class; (4) Take words apart; (5) Build…

Instructor, 2011

2011-01-01

227

Susac's Syndrome in a 27-Year-Old Female.  

PubMed

A 27-year-old woman was referred by the neurologist for ophthalmic examination. She had a history of headache, visual loss in her right eye, four-limb paresthesia, and behavioral changes over the previous 10 months. The patient complained of tinnitus and hearing loss for two weeks. The patient was initially diagnosed with multiple sclerosis, but auditory and retinal involvement (small branch retinal artery occlusion in fluorescein angiography) raised the possibility of Susac's syndrome. PMID:22224024

Adelpoor, Mohsen; Farahvash, Mohammad Sadegh; Fard, Masoud Aghsaei; Nikdel, Mojgan; Kiarudi, Mohammad Yaser

2011-10-01

228

Susac's Syndrome in a 27-Year-Old Female  

PubMed Central

A 27-year-old woman was referred by the neurologist for ophthalmic examination. She had a history of headache, visual loss in her right eye, four-limb paresthesia, and behavioral changes over the previous 10 months. The patient complained of tinnitus and hearing loss for two weeks. The patient was initially diagnosed with multiple sclerosis, but auditory and retinal involvement (small branch retinal artery occlusion in fluorescein angiography) raised the possibility of Susac's syndrome.

Adelpoor, Mohsen; Farahvash, Mohammad Sadegh; Fard, Masoud Aghsaei; Nikdel, Mojgan; Kiarudi, Mohammad Yaser

2011-01-01

229

Giant mediastinal thymolipoma in 35-year-old women.  

PubMed

The patient was 35-year-old women with a six-month history of difficulty breathing and chest pain. An anterior-posterior chest radiograph revealed a widened mediastinum with small lung volumes. During his diagnostic evaluation, a computed tomographic scan was performed and with huge mass in the anterior mediastinum with extension to the left and right side of pleural space. With postero-lateral thoracotomy the huge mass was resected. The patient discharged with good condition. PMID:24250956

Aghajanzadeh, Manuchehr; Alavi, Ali; Pourrasouli, Zahra; Aghajanzadeh, Gilda; Massahnia, Sara

2011-01-01

230

Giant Mediastinal Thymolipoma in 35-Year-Old Women  

PubMed Central

The patient was 35-year-old women with a six-month history of difficulty breathing and chest pain. An anterior-posterior chest radiograph revealed a widened mediastinum with small lung volumes. During his diagnostic evaluation, a computed tomographic scan was performed and with huge mass in the anterior mediastinum with extension to the left and right side of pleural space. With postero-lateral thoracotomy the huge mass was resected. The patient discharged with good condition.

Aghajanzadeh, Manuchehr; Alavi, Ali; Pourrasouli, Zahra; Aghajanzadeh, Gilda; Massahnia, Sara

2011-01-01

231

16YearOld Female with Amenorrhea  

Microsoft Academic Search

Tadanori Tomita, MD: A 16.5-year-old girl was referred to the endocrinology service for evaluation of primary amenorrhea. She had not noticed any breast development, axillary or pubic hair. She had never had a menses. Upon questioning, she was found to be suffering from a 7-year history of enuresis, polydipsia, and polyuria. She stated that her urine was always light in

Michael D. Partington; Mary Ann Radkowski; Tadanori Tomita

1998-01-01

232

Pathological intracranial extradural hematoma in a 10-year-old child  

PubMed Central

A nontraumatic spontaneous extradural hematoma, in a fully conscious 10-year-old male child, caused by a solitary eosinophilic granuloma of calvarium presented as a case of localized painful swelling of the head, which rapidly expanded and decreased in size. A plain CT-scan of the head with bone window revealed eroded right parietal bone with subperiosteal debris and extradural hematoma of mixed density. Immediate evacuation of the extradural clot and complete excision of the lesion was performed to prevent the deterioration of the patient and to achieve the histological diagnosis for further management.

Bhat, Abdul Rashid; Jain, Ashish Kumar; Kirmani, A. R.; Nizami, Furqan

2010-01-01

233

Identification of Strategies for Penetrating the 19-to-23-Year-Old Recruiting Market.  

National Technical Information Service (NTIS)

Nine marketing strategies were evaluated for their potential effectiveness in attracting and enlisting a target population of 19-to 23-year old, unmarried, nonprior-service males with high school diplomas. The evaluation was based on information obtained ...

A. P. Romanczuk B. E. Goodstadt C. L. Colby K. Fernandes

1982-01-01

234

A 3YearOld Girl with Headaches and Ataxia  

Microsoft Academic Search

Tadanori Tomita: This is a 3.5-year-old Caucasian female from the Island of Crete in Greece. She had been normal until 2 months prior to admission, when she started to have increasing headaches, instability and dizziness involving ataxia. She also started to have a head tilt. The patient was noted to have an ocular anomaly by a local ophthalmologist in Greece,

Harold Rekate; Tadanori Tomita; Guillermo A. de Leon; Mary Ann Radkowski

1999-01-01

235

Vesicular pemphigoid in a 16-year-old boy  

Microsoft Academic Search

We describe a case of a 16-year-old African-American boy with bullous pemphigoid (BP), an acquired autoimmune blistering disease that is rarely seen in children. The patient's lesions, however, were distinctly herpetiform, complicating initial diagnosis and therapy. A diagnosis of BP was made by direct and indirect immunofluorescence. Immunoblotting and enzyme-linked immunosorbent assay analysis confirmed the presence of autoantibodies directed against

Adam S Geyer; Detlef Zillikens; Christian Skrobek; Bernard Cohen; Grant J Anhalt; Hossein C Nousari

2003-01-01

236

Clarithromycin induced psoriasis in a 37-year old man.  

PubMed

Many drugs may induce psoriatic lesions or exacerbate preexisting psoriasis. We report an exceptional case of psoriasis vulgaris probably induced by clarithromycin. A 37-year-old man was prescribed for pharyngitis clarithromycin 500mg twice a day. On the third day of treatment, he presented a non pruriginous erythemato-squamous eruption, of trunk and limbs. Skin biopsy showed a typical aspect of psoriasis vulgaris. The drug was interrupted and the patient was treated by topical corticoids with rapid improvement. PMID:24410388

Zaiem, Ahmed; Mebazaa, Amel; Lakhoua, Ghozlane; Badri, Talel; Sahnoun, Rym; Kastalli, Sarrah; Daghfous, Riadh; El Aidli, Sihem

2014-03-01

237

Development of 5- and 10-year-old pediatric phantoms based on polygon mesh surfaces  

SciTech Connect

Purpose: The purpose of this study is the development of reference pediatric phantoms for 5- and 10-year-old children to be used for the calculation of organ and tissue equivalent doses in radiation protection. Methods: The study proposes a method for developing anatomically highly sophisticated pediatric phantoms without using medical images. The 5- and 10-year-old male and female phantoms presented here were developed using 3D modeling software applied to anatomical information taken from atlases and textbooks. The method uses polygon mesh surfaces to model body contours, the shape of organs as well as their positions, and orientations in the human body. Organ and tissue masses comply with the corresponding data given by the International Commission on Radiological Protection (ICRP) for the 5- and 10-year-old reference children. Bones were segmented into cortical bone, spongiosa, medullary marrow, and cartilage to allow for the use of micro computer tomographic ({mu}CT) images of trabecular bone for skeletal dosimetry. Results: The four phantoms, a male and a female for each age, and their organs are presented in 3D images and their organ and tissue masses in tables which show the compliance of the ICRP reference values. Dosimetric data, calculated for the reference pediatric phantoms by Monte Carlo methods were compared with corresponding data from adult mesh phantoms and pediatric stylized phantoms. The comparisons show reasonable agreement if the anatomical differences between the phantoms are properly taken into account. Conclusions: Pediatric phantoms were developed without using medical images of patients or volunteers for the first time. The models are reference phantoms, suitable for regulatory dosimetry, however, the 3D modeling method can also be applied to medical images to develop patient-specific phantoms.

Melo Lima, V. J. de; Cassola, V. F.; Kramer, R.; Oliveira Lira, C. A. B. de; Khoury, H. J.; Vieira, J. W. [Department of Anatomy, Federal University of Pernambuco, Avenida Professor Moraes Rego 1235, CEP 50670-901, Recife, Pernambuco (Brazil); Department of Nuclear Energy, Federal University of Pernambuco, Avenida Professor Luiz Freire 1000, CEP 50740-540, Recife, Pernambuco (Brazil); Federal Institute of Education, Science and Technology of Pernambuco, Avenida Professor Luiz Freire 500, CEP 50740-540, Recife, Pernambuco, Brazil and Polytechnic School of Pernambuco, University of Pernambuco, Rua Benfica 455, CEP 50751-460, Recife, Pernambuco (Brazil)

2011-08-15

238

Lobular Breast Cancer in a Male Patient with a Previous History of Irradiation Due to Hodgkin's Disease  

PubMed Central

Background Male breast cancer is rare and represents less than 1% of all breast cancers. Considering the fact that the male breast most often does not consist of lobules and acini, lobular carcinoma of the male breast is exceptionally rare. Case Report In this paper we present a unique case of alveolar variant of lobular male breast cancer in a 56-year-old patient. Conclusion According to our knowledge this is the first presentation of an alveolar variant of lobular male breast cancer that appeared 14 years after chemo- and radiotherapy for the treatment of Hodgkin's disease.

Ninkovic, Srdjan; Azanjac, Goran; Knezevic, Milan; Radovanovic, Dragce; Canovic, Dragan; Nedovic, Jasmina; Mitrovic, Slobodanka

2012-01-01

239

Multiple saccular aneurysms of the extracranial and intracranial internal carotid artery associated with convexobasia and arachnoid cyst in a 6-year-old boy: a case report  

Microsoft Academic Search

Introduction  We report an extremely rare case of multiple saccular aneurysms of the extracranial and intracranial internal carotid artery\\u000a associated with convexobasia of the left temporal region and arachnoid cyst in a 6-year-old boy.\\u000a \\u000a \\u000a \\u000a Case Report  A 6-year-old male patient was admitted to the hospital with chief complaint of ptosis and engorgement of the left eyelid for\\u000a 50 days. A 4?×?10-cm bony protuberance

Taiji Sun; Jizong Zhao

2010-01-01

240

[Massive ovarian edema in a 13-year-old girl].  

PubMed

Massive ovarian edema is a rare tumor-like condition found in young women resulting from accumulation of fluid mostly due to partial or intermittent torsion of the ovary or secondary, to a preexisting ovarian lesion. We report a case of a 13-year-old girl presenting with an ovarian mass measuring 16 cm. CA-12-5 levels were slightly elevated. Concerns regarding underlying malignancy led to salpingo-oophorectomy. Pathological evaluation revealed a massive ovarian edema and multiple thromboses of ovarian veins. Differentiating massive ovarian edema from malignant ovarian tumor is crucial to prevent patients from undergoing unnecessary surgery. PMID:23649810

Sailer, V; Huss, S; Wardelmann, E; Müller, A M

2013-11-01

241

An abdominal mass in a 4-year-old child.  

PubMed

The author describes a 4-year-old boy who presented to the accident and emergency department after a mass in his abdominal wall had been rapidly enlarging for at least a week. There was a delay in management due to difficulty reaching the diagnosis. Once obtained, a CT scan revealed the true diagnosis; an infected intramuscular haematoma arising from the right abdominal oblique muscles. This was large enough to displace the right lobe of the liver medially. The patient was treated with surgical drainage and intravenous antibiotics. PMID:22922923

Counsell, Heather

2012-01-01

242

Blowout fracture in a 3-year-old.  

PubMed

A 3-year-old patient was referred to the oral and maxillofacial department with a fracture of the orbital floor. Due to the lack of clinical symptoms, a conservative approach was chosen. After 3 weeks, an enophthalmos developed. The orbital floor reconstruction was successfully performed through a transconjunctival approach. This case highlights the rarity of pure blowout fractures in young children. The specific presentation and diagnostics of orbital floor fractures in children and the related surgical planning and intervention are discussed. PMID:24436749

Pluijmers, Britt I; Koudstaal, Maarten J; Paridaens, Dion; van der Wal, Karel G H

2013-06-01

243

Intracystic Papillary Carcinoma of the Breast in a Male Patient: A Case Report  

PubMed Central

Breast carcinoma is an uncommon neoplastic condition among man, accounting for not more than 1% of all breast cancers. Intracystic papillary carcinoma in man is an extremely rare condition and represents only 5–7,5% of all male breast carcinomas. Clinical and radiological manifestations of intracystic papillary carcinomas are not specific. Pathologic diagnosis can be difficult at classical histological examination and identification of myoepithelial cells layer by immunohistochemical study can be useful. Adjuvant therapy is still controversial and prognosis is excellent. We report a case of this rare histological type of breast cancer in 48-year-old male patient and review the literature.

Muallaoglu, Sad?k; Ozdemir, Ersin; Kutluay, Lale

2012-01-01

244

Medical Care and Your 6- to 12-Year-Old  

MedlinePLUS

... Pregnant? Your Baby's Growth Medical Care and Your 6- to 12-Year-Old KidsHealth > Parents > Doctors & Hospitals > Doctor & Hospital Visits > Medical Care and Your 6- to 12-Year-Old Print A A A ...

245

[Decompensated liver cirrhosis caused by galactosemia in a 52-year-old man].  

PubMed

A 52-year-old oligophrenic man hospitalized for esophageal hemorrhage had histologically proven liver cirrhosis and died from massive rehemorrhage. As a neonate he had survived severe jaundice, had had delayed psychomotor development and remained severely retarded. At age 15 years, bilateral cataracts had been excised and from 18 to 25 years he had had occasional grand mal seizures. The triad oligophrenia, liver cirrhosis and cataracts, prompted suspicion of galactosemia. Deficiency of galactose-1-phosphate uridyltransferase was demonstrated in blood and post mortem tissue. At autopsy, liver cirrhosis and esophageal varices were confirmed and unilateral chronic pyelonephritis, bilateral nephrolithiasis and testicular atrophy were found. There was not brain pathology. The patient appeared to be the oldest nondiagnosed galactosemic and the first male patient in whom hypogonadism was documented. PMID:7455652

Vogt, M; Gitzelmann, R; Allemann, J

1980-11-22

246

Fertility control in the under 16 year old  

Microsoft Academic Search

Providing contraception and sexual health to under 16 year olds remains a controversial and emotive issue despite clear guidance and the fact that 20–30% of young people report having had their first experience of sexual intercourse by the age of 16 years old.Competent under 16 year olds have the ability to consent to medical treatment and the duty of confidentiality

S. Hughes

2001-01-01

247

Traumatic Dental Injuries Among 12-15-Year-Old-School Children in Panchkula  

PubMed Central

Background: Traumatic dental injury (TDI) in children and adolescents has become one of the most serious dental public health problems. Despite such a high prevalence of dental trauma, very less attention has been paid to TDI, its etiology, and prevention. Objectives: To determine the prevalence of anterior tooth traumatic dental injuries in 12-15-year-old school children of Panchkula district, India, and to find any correlation with the cause, gender, extent of overbite as well as over-jet, and previous treatment. Patients and Methods: A multistage sample of 12-15-year-old school children (n = 810) in Panchkula district, Haryana, was selected. The children were screened using WHO criteria for oral examination and a trained dental surgeon examined the children. Those with clinical TDI were examined further for the type of traumatic injuries using Elis classification modified by Holland. Overjet and overbite were recorded. After examination, questions regarding the cause of trauma and its treatment were asked. Data were subjected to statistical analysis using the Chi square and Mantel-Haenszel tests by SPSS version 20.0. Results: The results showed that out of 810 children, 86 (10.2 %) had TDI. Males had higher prevalence of trauma than females (P < 0.05). The common cause of trauma was fall (51.11%) followed by sports injuries (41.86%). Enamel-dentin fracture without pulpal involvement was the most common type of trauma and the most frequent involved teeth were maxillary central incisors. A significant association was observed between overjet and overbite and trauma. Only 3.5% of the children affected with trauma had received treatment. Conclusions: The prevalence of traumatic injuries to permanent incisors in 12-15-year-old Panchkula school children was relatively high. TDI was associated with gender, overjet, and lip competence. There was a great unmet treatment need.

Chopra, Amandeep; Lakhanpal, Manav; Rao, NC; Gupta, Nidhi; Vashisth, Shelja

2014-01-01

248

Hypoglycaemia in a 94-year-old man without diabetes.  

PubMed

Recognising a hypoglycaemic event in a person without a history of diabetes poses quite a challenge. A 94-year-old man without diabetes in an extended care facility (ECF) was found unconscious and non-responsive with a glucose level of 30?mg/dL. The patient required multiple resuscitations with glucagon and intravenous glucose before his blood glucose stabilised. Ultimately the accidental administration of a sulfonylurea was found to be responsible for the event. The patient fortunately recovered after 5?days of hospitalisation. Adults aged 65?years and older carry a significantly higher risk of serious adverse drug events (ADEs) requiring hospitalisation. Antidiabetic drugs cause nearly one-quarter of all hospitalisations from ADEs, with more than 99% due to unintentional overdose. To truly optimise patient care, providers must be cognizant of the risks associated with diabetes management to better monitor and prevent future occurrence of such taxing events. PMID:24849646

Mullens, Dustin James; Shubrook, Jay H

2014-01-01

249

An 85-year-old woman with Miller Fisher syndrome  

PubMed Central

Miller Fisher’s syndrome (MFS) commonly presents in the fourth and fifth decades and are rare in people over 70 years. An 85-year-old female with no significant medical history presented with upper extremity anesthesia, ptosis, and unsteady gait. The patient had a history of hypertension and diabetes mellitus. Physical examination showed bilateral total external ophthalmoplegia, areflexia, and cerebellar ataxia. Radiological and laboratory studies were unremarkable. Lumbar puncture showed albuminocytological dissociation. The combined history, physical examination, and lumbar puncture results established a presumptive diagnosis of MFS. Intravenous immunoglobulin was given for 5 days. The patient gradually improved 10 days after the onset of symptoms. Ophthalmoplegia had fully recovered after 6 months. To the best of our knowledge, this case represented the oldest patient with MFS.

Wang, Shu-hui; Zhang, Yong-bo; Xie, Yan-chen; Wang, De-xin; Li, Ji-mei

2013-01-01

250

Obstructive perianal lesion in a 75-year-old man  

PubMed Central

A 75-year-old man presented with a fungating peri-anal mass which appeared malignant at presentation and required a defunctioning colostomy due to abdominal distension. Multiple biopsies were negative for malignancy and CT/MRI scans showed no malignant mass. A provisional diagnosis of prolapsed haemorrhoids was made and the mass was treated with sugar and charcoal dressings. There was a dramatic resolution of the mass with this treatment and the patient was discharged 1 month post-admission. The patient then underwent an elective haemorrhoidectomy by which time the mass had decreased to a perianal skin tag. The only clues in this case were the acute presentation of the mass, the fact that the mass had appeared post-defecation and that the patient had been diagnosed with haemorrhoids 2 years previously on colonoscopy. This case highlights the importance of evaluating all investigations and considering all differential diagnoses before embarking on definitive management.

Maitra, Rudra Krishna; Pinkney, Thomas; Subramonia, Sriram; Acheson, Austin G

2012-01-01

251

Prophylactic gastrectomy in a 16-year-old.  

PubMed

We performed a total gastrectomy in a 16-year-old asymptomatic CDH1 gene mutation carrier in whom two prior gastroscopies with biopsies were normal. The patient's mother died aged 39 years and her aunt died aged 21 years of gastric cancer. A germline CDH1 mutation (associated with hereditary diffuse gastric cancer) was initially identified in her mother at diagnosis and was later identified by predictive testing in this patient. Our patient is the youngest CDH1 carrier to date to have a prophylactic gastrectomy, and is several years below the age at which existing guidelines recommend consideration of gastrectomy. Multiple foci of early-stage carcinoma were found in her gastrectomy specimen. Given the family history of advanced gastric cancer in the late second decade, the unpredictable time course to development of advanced gastric cancer, and the futility of gastroscopic surveillance, we recommend consideration of prophylactic gastrectomy in adolescent asymptomatic CDH1 mutation carriers on an individual basis. PMID:24240619

Wickremeratne, Tehara; Lee, Cheng Hiang; Kirk, Judy; Charlton, Amanda; Thomas, Gordon; Gaskin, Kevin J

2014-03-01

252

Spontaneous Coronary Artery Dissection in a Male Patient with Takayasu's Arteritis and Antiphospholipid Antibody Syndrome  

PubMed Central

We present a case of a 34-year-old male who presented to the emergency ward with fever and abdominal pain. The diagnosis of Takayasu's arteritis and also antiphospholipid syndrome was made during an imaging workup of deep-vein thrombosis. A spontaneous coronary artery dissection was revealed in coronary CT angiography requested for chest pain and dyspnea. The patient was treated medically and discharged on close followup. The concurrence of spontaneous coronary artery dissection with antiphospholipid syndrome and Takayasu's arteritis has not been reported in the previous literature. The possibility of a spontaneous coronary artery dissection should be considered in patients presenting with both diseases.

Gerede, Demet Menekse; Yuksel, Bagdagul; Tutar, Eralp; Kucuksahin, Orhan; Uzun, Caglar; Atasoy, Kayhan Cetin; Duzgun, Nursen; Bengisun, Ugur

2013-01-01

253

Simvastatin-induced dermatomyositis in a 50-year-old man  

PubMed Central

Dermatomyositis (DM) is a rare inflammatory autoimmune disease for which an iatrogenic origin has been described in a few cases. The authors report a case of DM occurring after simvastatin intake. A 50-year-old male sought medical attention for a photodistributed rash and considerable muscular weakness present for 3 months. One year earlier, simvastatin had been introduced. Serum creatine kinase levels were elevated. Histological examination of a muscle biopsy was consistent with a diagnosis of DM. Investigation for neoplasia and associated autoimmune disease proved negative. All clinical and laboratory abnormalities diminished corticosteroid therapy (1 mg/kg/day). Case reports have suggested that lipid-lowering drugs, especially statins, could induce or reveal chronic muscle diseases. In statins myopathy, reduction of coenzyme Q has been discussed as a key mechanism. Our case of DM in a patient receiving simvastatin adds to the previous reported cases in the literature and highlights the potential role of statins as triggers of immune systemic diseases.

Zaraa, Ines Rania; Labbene, Imen; Mrabet, Dalila; Zribi, Hela; Chelly, Ines; Zitouna, Mohamed; Mokni, Mourad; Sellami, Slaheddine; Osman, Amel Ben

2011-01-01

254

Size of external genital organs and somatometric parameters among physically normal men younger than 40 years old  

Microsoft Academic Search

Objectives. To estimate the sizes of the external genital organs in physically normal adult males younger than 40 years old, as well as to correlate the resulting values with age and a number of somatometric parameters, to provide data that could be clinically applicable by the practicing urologist.Methods. Fifty-two physically normal men, 19 to 38 years old, underwent tape measurements

Evangelos Spyropoulos; Dimitrios Borousas; Stamatios Mavrikos; Athanasios Dellis; Michael Bourounis; Sotirios Athanasiadis

2002-01-01

255

Rapunzel Syndrome Case Report: A 13-year-old Girl.  

PubMed

Bezoars are masses, which are commonly encountered in patients after stomach surgery or in those with psychiatric problems, formed by the accumulation of intraluminal nondigestible substances that can lead to obstruction of the stomach and the small intestine. The anatomical changes in the gastrointestinal tract are known to cause bezoar formation. In the absence of an anatomical change, psychiatric disorders such as trichotillomania may lead to the formation of trichobezoars in the stomach. The so-called Rapunzel syndrome is the extension of the bezoars down to the duodenum and the jejunum, which is a rare condition. In this paper, a 13-year-old patient with trichotillomania is reported, who was admitted to our clinic with nausea, vomiting, and fatigue complaints, in whom a giant trichobezoar was identified, which completely filled the stomach and duodenum, without causing obstruction. PMID:23766614

Ozdemir, Hakan; Ozdemir, Zehra U; Sahiner, Ibrahim T; Senol, Metin

2012-10-01

256

Choline associated hypersexuality in a 79-year-old man.  

PubMed

Hypersexuality, also referred to as sexually inappropriate behavior and sexual disinhibition, involves persistent, uninhibited sexual behaviors directed at oneself or at others, sometimes associated with neurodegenerative disorders. Choline is a water-soluble essential nutrient, used as a dietary supplement in different diseases. This report was aimed at considering choline intake as a possible cause of iatrogenic hypersexuality. After an evaluation, a 79-year-old man affected by memory loss was diagnosed with mild cognitive impairment and treated with oral choline. After 6 weeks of regular choline assumption, the patient showed a pathological increase in libido with sexual urges. As choline was withdrawn, the hypersexuality disappeared within 5 days. Since hypersexuality may be an underreported and overlooked adverse effect of drugs and dietary supplements acting on the cholinergic pathway, this should be considered when treating and counselling patients with inappropriate sexual behavior. PMID:23733158

Calabrò, Rocco Salvatore; Cordici, Francesco; Genovese, Carmelo; Bramanti, Placido

2014-01-01

257

A 29-Year-Old Harken Disk Mitral Valve  

PubMed Central

An 81-year-old woman was evaluated for prosthetic mitral valve function. She had received a Harken disk mitral valve 29 years earlier due to severe mitral valve disease. This particular valve prosthesis is known for premature disk edge wear and erosion. The patient's 2-dimensional Doppler echocardiogram showed the distinctive appearance of a disk mitral valve prosthesis. Color Doppler in diastole showed a unique crown appearance, with initial flow acceleration around the disk followed by convergence to laminar flow in the left ventricle. Cineradiographic imaging revealed normal valve function and minimal disk erosion. We believe this to be the longest reported follow-up of a surviving patient with a rare Harken disk valve. We present images with unique echocardiographic and cineangiographic features. (Tex Heart Inst J 2003;30:319–21)

Hsi, David H.; Ryan, Gerald F.; Taft, Janice; Arnone, Thomas J.

2003-01-01

258

Sciatica in a Five-Year-Old Boy  

PubMed Central

The prevalence of back pain during childhood is 50%; in 22% of these cases, a specific diagnosis can be found. Osteoid osteoma is a rare benign tumor that occursonly in 20% of cases and involves the spine. The aim of this report is to explain an atypical case of lumbar osteoid osteoma with significant neurologic deficit at a very young age. A five-year-old boy was presented with refractory pain in the low back and left extremity for approximately one year. Positive clinical findings were antalgic gait, stiff lumbar spine, weak left big toe extension force and a positive straight leg rising test on the left side. Paraclinical studies revealed osteoid osteoma in the left-sided pedicle of the fifth lumbar vertebra. With surgical excision, he recovered immediately. Lumbar osteoid osteoma should be suspected as the cause of low back pain or sciatalgia in any young patient.

Hasankhani, Ebrahim Ghayem; Rafeemanesh, Ehsan

2014-01-01

259

Twelve-Year-Old Girl with Primary Biliary Cirrhosis  

PubMed Central

Primary biliary cirrhosis (PBC) is a slowly progressive cholestatic liver disease of autoimmune etiology. The initial presentation of PBC is varies from asymptomatic, abnormal liver biochemical tests to overt cirrhosis. Unlike other autoimmune liver diseases, PBC has rarely been reported in childhood. We report a case of primary biliary cirrhosis in a 12-year-old girl. In addition to characteristic histology features, strongly positive antimitochondrial antibodies, increased liver enzyme levels, increased serum quantitative immunoglobulin M levels, and cholestasis were discovered. She had been treated with ursodeoxycholic acid. In the world literature, we found only few pediatric patients of primary biliary cirrhosis. Aetiology, pathogenesis, the long-term natural history, and prognosis remain obscure. Due to increased awareness of early-onset PBC, rather than typical older ones, further pediatric cases may be discovered.

Kitic, Ivana; Boskovic, Aleksandra; Stankovic, Ivica; Prokic, Dragan

2012-01-01

260

[Circumscript myositis ossificans in a four-year-old boy].  

PubMed

We present the case of a 4 year old boy with no previous personal or family history of interest, who attended the Paediatric Department of our hospital after a physical examination revealed a painful induration in the left arm which had increased in size; imaging tests were consistent with a calcified mass in soft tissues, without cortical involvement, suspected of being malignant. Two-phase bone scintigraphy was requested in which a soft tissue lesion, not suggestive of malignancy, was detected. The biopsy was negative for malignant cells. However, in view of the progressive increase in size of the lesion, FDG positron emission tomography (FDG-PET) was performed, showing a hypermetabolic mass consistent with malignancy in the left arm, for which the patient underwent surgery for suspected possible parosteal osteosarcoma. PMID:18817666

Cabello García, D; Rodríguez Fernández, A; Gómez Río, M; Moreno, M J; Rebollo Aguirre, A C; Martín Castro, A; Llamas Elvira, J M

2008-01-01

261

Scurvy in a 10-year-old boy.  

PubMed

Scurvy, or hypovitaminosis C, is an uncommon condition that exists today primarily within certain unique populations-particularly the elderly subjects, patients with neurodevelopmental disabilities or psychiatric illnesses, or others with unusual dietary habits. Vitamin C is an essential nutrient in the human body, and is important in synthesizing collagen factor whose faulty production is responsible for most of the clinical manifestations of scurvy. These clinical manifestations can include dystrophic or corkscrew hairs, gingival hyperplasia, and weakened blood vessel walls, causing bleeding in the skin, joints, and other organs. Although rare in the Unites States, the presence of scurvy should not be forgotten because of its presence among susceptible populations. Moreover, with its diagnosis, treatment and cure is one of the simplest in modern medicine. We report a case of scurvy in a 10-year-old autistic child. PMID:20561240

Cole, John A; Warthan, Molly M; Hirano, Stefanie A; Gowen, Clarence W; Williams, Judith V

2011-01-01

262

Talocalcaneal coalition in a 15 year old female basketball player  

PubMed Central

This case reports an adolescent athlete with activity related chronic bilateral dorsal foot pain and stiffness. A 15 year old competitive female basketball player presented to a chiropractor subsequent to an unsuccessful course of conservative treatment for posterior tibial dysfunction. The patient’s plain films were incorrectly read as normal and a CT scan obtained by the radiologist called the findings bilateral osteoarthritis. The patient was awaiting a referral to a rheumatologist at the time of initial consultation with the chiropractor. Examination revealed limited subtalar mobility and review of the images revealed bilateral non-osseous talocalcaneal coalition. The patient was subsequently directed to a pediatric orthopedic surgeon and is scheduled for a resection of the coalition. Primary care practitioners should be aware of this uncommon, but not rare, variable clinical presentation as misdiagnosis and mismanagement could lead to suboptimal patient outcomes. To our knowledge this is the first case report of a patient with tarsal coalition published in chiropractic literature. In addition, this case is the first to report radiographic evidence of chronic mechanical stress to the second metatarsal associated with tarsal coalition.

Schenkel, David; deGraauw, Jennifer; deGraauw, Christopher

2010-01-01

263

Feeding Your 1- to 2-Year-Old  

MedlinePLUS

Feeding Your 1- to 2-Year-Old KidsHealth > Parents > Growth & Development > Feeding & Eating > Feeding Your 1- to 2-Year-Old Print A A A ... skills develop, step back and let your little one take over. Toddlers also like to assert their ...

264

Growth and Your 2- to 3-Year-Old  

MedlinePLUS

Growth and Your 2- to 3-Year-Old KidsHealth > Parents > Growth & Development > Growth > Growth and Your 2- to 3-Year-Old Print A A A Text Size ... 1.8 kilograms) and grow about 2 to 3 inches (5 to 8 centimeters). They're extremely ...

265

Virilizing ovarian steroid cell tumor in a 40 year old South Indian female: a case report  

Microsoft Academic Search

Virilism is the masculinization and enhancement of male secondary sexual characteristics in females. The etiology is usually of adrenal or ovarian origin. Here we report a case of virilizing Leydig cell type, steroid cell tumor of the left ovary, in a 40 year old female who presented with clinical signs and symptoms of virilization: deepening of voice, hirsutism (Ferriman-Gallwey score

Shihas Salim; Ghanshyam Palamaner Subash Shantha; Amish Dilip Patel; Anita A Kumar; Prasanthi Ganeshram; Nikita Mehra; Anish George Rajan; Tarun Joseph; Lavangi Sudhakar

2009-01-01

266

Personal and Social Correlates of the "Closed Mind" among 16-Year-Old Adolescents in England.  

ERIC Educational Resources Information Center

Compares what is known about key personal and social correlates of scores on Rokeach dogmatism scales with findings from a new study of English 16-year-old pupils. Demonstrates that higher dogmatism scores are associated with lower IQ scores, lower social-class backgrounds, higher neuroticism scores, higher lie-scale scores, and being male. (DSK)

Francis, Leslie J.

1997-01-01

267

Differential Parental Effects Among One-Year-Old Infants in a Stranger and Separation Situation.  

ERIC Educational Resources Information Center

This study examined the differential effects of sex of parent, sex of child, and sex of stranger on infant behavior in a stranger-separation situation. Year-old infants (16 males and 19 females) from middle-class families were observed and videotaped twice, at one-week intervals, in a modification of Ainsworth's laboratory stranger and separation…

Keller, Harold R.; And Others

268

Mucinous cystic neoplasm of the pancreas in a male patient  

PubMed Central

Mucinous cystic neoplasms (MCNs) make up a morphologic family of similar appearing tumors arising in the ovary and various extraovarian organs such as pancreas, hepatobiliary tract and mesentery. MCNs of the pancreas occur almost exclusively in women. Here, we report a rare case of MCN in a male patient. A 39-year-old man was admitted to our hospital with the chief complaint of back pain. Abdominal computed tomography revealed a multilocular cyctic mass 6.3 cm in diameter in the pancreatic tail. In addition, the outer wall and septae with calcification were demonstrated in the cystic lesion. On magnetic resonance imaging , the cystic fluid had low intensity on T1-weighted imaging and high intensity on T2-weighted imaging. Endoscopic retrograde cholangio-pancreatography (ERCP) showed neither communication between the cystic lesion and the main pancreatic duct nor encasement of the main pancreatic duct. Endoscopic ultrasonography revealed neither solid component nor thickness of the septae in the cystic lesion. Consequently, we performed distal pancreatectomy with splenectomy under the diagnosis of cystic neoplasia of the pancreas. Histopathologically, the cystic lesion showed two distinct component: an inner epithelial layer and an outer densely cellular ovarian-type stromal layer. Based on these findings, the cystic lesion was diagnosed as MCN.

Tokuyama, Yasuharu; Osada, Shinji; Sanada, Yuichi; Takahashi, Takao; Yamaguchi, Kazuya; Yoshida, Kazuhiro

2011-01-01

269

Clustering of Health-Related Behaviors among 18YearOld Australians  

Microsoft Academic Search

Background.Few studies among young adults have examined clustering of health behaviors affecting risk for lifestyle diseases.Methods.Smoking, alcohol consumption, physical activity, and diet were examined among Australian 18-year-olds (301 males, 282 females) initially recruited at the age of 9 years from 26 schools. Association analysis was used to recognize behavior clustering.Results.Fat intake was greater among male smokers than nonsmokers (36% energy

V. Burke; R. A. K. Milligan; L. J. Beilin; D. Dunbar; M. Spencer; E. Balde; M. P. Gracey

1997-01-01

270

Primary Cardiac Angiosarcoma in a 25-Year-Old Man  

PubMed Central

Primary cardiac tumors do not occur frequently, and only one quarter of them, chiefly sarcomas, are malignant. Patients with angiosarcoma typically have a shorter survival time than do patients with other sarcomas, and the prognosis for survival depends strictly on the stage of the disease at the time of diagnosis and the possibility of complete surgical excision. Chemotherapy and radiotherapy have well-established postoperative roles because of the high probability of metastasis. We report the case of a 25-year-old man who presented with pericardial effusion and echocardiographic evidence of an intracavitary right atrial mass but without the bulky, infiltrative growth typical of this location of the disease. Malignancy was suggested by the clinical presentation, the location of the mass in the right side of the heart, and the absence of conditions favoring thrombus formation. After complete surgical excision, the mass was confirmed to be an angiosarcoma. Conventional adjuvant chemotherapy and maintenance therapy with inhibitors of CD117 (c-kit) and vascular endothelial growth factor relieved the patient's clinical symptoms and enabled his long-term, disease-free survival. In addition to reporting this case, we discuss aspects of the diagnosis and treatment of angiosarcoma.

Bellitti, Renato; Buonocore, Marianna; De Rosa, Nicolina; Covino, Franco Enrico; Casale, Beniamino; Sante, Pasquale

2013-01-01

271

Ocular alignment and refraction in preterm children at 1 and 6 years old  

PubMed Central

Purpose To investigate cycloplegic refraction and ocular alignment in a population of preterm children at 1 and 6 years old. Patients and methods We included 261 preterm infants with a birth weight ?1,500 g and a gestational age ?32 weeks; there were 217 preterm infants (group 1), 28 preterm infants with mild retinopathy of prematurity (ROP) (group 2), and 16 preterm infants affected by severe ROP (group 3). Each patient underwent retinoscopy, ocular alignment assessment, and fundus examination at 1 and 6 years old. Results The prevalence of refractive errors and ocular alignment abnormalities at 1 year old in groups 2 and 3 compared to group 1 were, respectively (P<0.05): myopia 18% and 40.6% versus 6.9%; hyperopia 28.6% and 22% versus 39.2%; astigmatism 53.4% and 37.4% versus 53.9%; and strabismus 12.5% and 38% versus 5.3%. At 6 years old, they were, respectively (P<0.05): myopia 10.8% and 28.4% versus 7.4%; hyperopia 48.3% and 40.5% versus 62%; astigmatism 40.9% and 31.1% versus 30.6%; and strabismus 25% and 56.25% versus 11.5%. Conclusion At 6 years old, we observed increased rates of both hyperopia and strabismus in all groups compared to 1-year-old children. In preterm children with mild and severe ROP, we recorded increased rates of myopia and strabismus versus preterm children without ROP, and the risk of developing these disorders increased significantly with ROP severity. Astigmatism at 1 year old is not predictive of further development during growth. Patients born prematurely should be informed of the possible risks of ocular alterations due to refractive and ocular component changes.

Al Oum, Muna; Donati, Simone; Cerri, Luigi; Agosti, Massimo; Azzolini, Claudio

2014-01-01

272

Primary retroperitoneal mucinous cystadenoma with borderline malignancy in a male patient: a case report  

PubMed Central

Introduction Primary retroperitoneal mucinous cystadenoma is a rare tumor prevailing specifically in female gender. Its histogenesis is still unclear and its diagnosis is mainly based on morphological characteristics. Case presentation the subject is a 44 years old man presenting an abdominal pain on the right side, with a palpable mass which appeared four months ago. Abdominal ultrasound (echography) revealed a retroperitoneal cystic process, which was successfully resected through laparotomy. Histopathological examination concluded to a mucinous cystadenoma with borderline malignancy foci. After a year of follow-up, no relapse was noticed in this patient. Conclusion Retroperitoneal mucinous cystadenoma is a rare tumor that should be considered in front of a retroperitoneal cystic process. Several hypotheses may explain the histogenesis of this pathological process. The interest in publishing this case report on primary retroperitoneal mucinous cystadenoma in a male patient lies in the rarity of occurrence of this syndrom in males as compared to females.

2009-01-01

273

Breast mass in a 69-year-old woman  

SciTech Connect

A 69-year-old woman was initially seen with constant abdominal pain in the epigastrium and right upper quadrant, with nausea and vomiting of three days' duration. On examination, moderate tenderness and guarding in the right upper quadrant of the abdomen were noted. A leukocytosis of 11,000/cu mm, with a mild shift to the left, was present. Findings from a sonogram and hepatobiliary scan were consistent with a diagnosis of acute cholecystitis for which intravenous (IV) antibiotic therapy was instituted. Results of radiological studies performed on the second hospital day showed a small-bowel obstruction. On surgical exploration, a gangrenous segment of the terminal ileum was resected and an end-to-end anastomosis was performed. The resected bowel demonstrated hemorrhagic infarction with evidence of focal organizing venous thrombosis in the mesentery. The patient was initially started on a regimen of IV heparin and then switched to oral coumarin. On the fourth day of coumarin therapy, massive swelling, tenderness, and erythema were noted to involve the entire right breast. Six months later, the patient was readmitted because of an acute pulmonary embolism. A residual 4x5-cm mass was present in the central portion of the right breast. The overlying skin was slightly retracted. Mammography showed an extensive masslike density behind the right nipple, with evidence of periareolar retraction. Coumarin-induced mammary necrosis was diagnosed.

Hermann, G.; Schwartz, I.S.; Slater, G.

1986-02-21

274

Identification of 180 Million Years Old, Probably Unchanged Melanine.  

National Technical Information Service (NTIS)

The comparison of the infrared spectra of recent sepia melanine and of the content of the ink sac of fossilized cuttlefish indicates that the 180 million years old substance is unchanged melanine. Both substances behave identically on heating. Other proce...

K. Beyermann D. Hasenmaier

1977-01-01

275

Fitness and Your 4-to 5-Year Old  

MedlinePLUS

Fitness and Your 4- to 5-Year-Old KidsHealth > Parents > Nutrition & Fitness Center > Staying Fit > Fitness and ... the risk of serious illnesses later in life. Fitness for Preschoolers The National Association of Sports and ...

276

Characteristics of molar pregnancy in a 12 year old.  

PubMed Central

Gestational trophoblastic disease rarely is reported in early teens. This article describes a 12-year-old black female with molar disease, in which the characteristics and treatment are not dissimilar from adults.

Chapman, G. W.

1996-01-01

277

Multiple myeloma revealed by spinal cord compression and herpes zoster in a 36-year-old Cameroonian  

PubMed Central

Multiple myeloma is a malignant plasma cell disorder occurring mostly in people above 60 years old. The authors describe a case of multiple myeloma in a 36-year-old patient revealed by spinal cord compression and Herpes zoster with a rapidly unfavourable outcome.

Sini, Victor; Kamtchum, Tatuene Joseph; Tegueu, Callixte Kuate; Djientcheu, Vincent De Paul

2013-01-01

278

Virilizing ovarian steroid cell tumor in a 40 year old South Indian female: a case report.  

PubMed

Virilism is the masculinization and enhancement of male secondary sexual characteristics in females. The etiology is usually of adrenal or ovarian origin. Here we report a case of virilizing Leydig cell type, steroid cell tumor of the left ovary, in a 40 year old female who presented with clinical signs and symptoms of virilization: deepening of voice, hirsutism (Ferriman-Gallwey score 26), clitoromegaly, and androgenic alopecia. On further evaluation, laboratory investigations revealed hyperandrogenism in the male range. Basal testosterone values were elevated. Folicle Stimulating Hormone and Luteinising Hormone levels were within normal limits. Dexamethasone suppression test did not alter cortisol or testosterone levels. An ovarian mass was confirmed radiologically. Following a total abdominal hysterectomy with bilateral salpingoophorectomy, histopathological studies confirmed a left sided steroid-cell ovarian tumor, Leydig cell type (stage T(1)N(0)M(0)), which proved to the etiology of virilization in this patient. Post-operatively her serum testosterone levels declined with near-complete reversal of symptoms over time. PMID:19829991

Salim, Shihas; Shantha, Ghanshyam Palamaner Subash; Patel, Amish Dilip; Kumar, Anita A; Ganeshram, Prasanthi; Mehra, Nikita; Rajan, Anish George; Joseph, Tarun; Sudhakar, Lavangi

2009-01-01

279

Crash involvements of 16-year-old drivers  

Microsoft Academic Search

All reported crashes—property damage, nonfatal injury, and fatal—estimated for 1993 in the National Highway Traffic Safety Administration's General Estimates System were examined for 16-year-old drivers. Results were compared to the crash involvements of other teenagers, older drivers, and fatal injury crash involvements as tabulated by the Fatal Accident Reporting System. Sixteen-year-olds were more likely than other teenagers and older drivers

Robert G. Ulmer; Allan F. Williams; David F. Preusser

1997-01-01

280

Three-year-old female with abdominal distention: Overview of a rare abdominal tumor in childhood  

Microsoft Academic Search

Lipoblastoma is a rare benign neoplasm of fetal- embryonal fat tissue. Asymptomatic abdominal mass, progressive abdominal distension, and radiolucent fat density mass on computed tomography are the main diagnostic criteria. Our patient was a 3-year old female who had been noted by mom to have abdominal distention almost since birth. The patient seemed to be having progressive abdominal distention, but

Jill Flippin; John Pohl; David Easley; Donald Cooney; Jose Santiago; Ludvik Donner

281

A 4-year-old girl with giant left atrial diverticulum resulting in severe mitral regurgitation.  

PubMed

Left atrial diverticulum is rare in a pediatric patient. A 4-year-old girl underwent a left atrial plication concomitant with mitral valve replacement, and early postoperative course was uneventful. This patient has remained asymptomatic with no evidence of recurrent diverticular formation after 9 months of follow-up. PMID:18402786

Nomura, Koji; Matsumura, Yoko; Shinohara, Gen; Nakamura, Yuzuru

2008-01-01

282

Deformities due to Leprosy in Children under Fifteen Years Old as an Indicator of Quality of the Leprosy Control Programme in Brazilian Municipalities  

PubMed Central

The present study aims at analysing the degree of deformity in leprosy cases diagnosed in children under 15 years old and its relationship with operational and epidemiological factors. This epidemiological cross-sectional study was carried out at municipalities of three microregions in a Brazilian hyperendemic area. Data between 1998 and 2010 was collected from the Information System for Notifiable Diseases database. The average coefficient of detection was 32.96/100.000 inhabitants; 7.61% of new cases were diagnosed in children under 15 years old; 5% in this age group were grade 2 deformity at diagnosis. Prevalence of leprosy cases in children under 15 years old with deformity was higher in males (PR = 2.65;P = 0.032; CI 95%: 1.09–6.45) and in multibacillary patients (PR = 14.68;P < 0.001; CI 95%: 3.54–60.87) and lower when the detection mode was passive (PR = 0.73,P = 0.47, CI 95%: 0.31–1.73). Such context suggests high transmissibility and early exposure to Mycobacterium leprae since a lot of cases were diagnosed in children under fifteen years old and the incubation period of the leprosy bacillus varies from 02 to 07 years. This situation contributes to maintaining the chain of disease transmission in the area and indicates that health care services should intensify leprosy control.

Lana, Francisco Carlos Felix; Fabri, Angelica da Conceicao Oliveira Coelho; Lopes, Fabiana Nascimento; Carvalho, Ana Paula Mendes; Lanza, Fernanda Moura

2013-01-01

283

AB 69. Coexistence of Wilson's disease and sarcoidosis in a 35-year-old female  

PubMed Central

Background The simultaneous diagnosis of two relatively rare co-existing diseases. Patients and methods Description of clinical and laboratory findings. Results A thirty-five year-old female was referred to a neurology department for symptoms of resting, postural and kinetic tremor of the upper extremities as well as head tremor. Diagnostic workup revealed Kaiser-Fleischer rings in both eyes, high levels of copper in the urine (200 ?g/24 h with normal value [n.v.] <100, low levels of ceruloplasmine (17.5 mg/dL-n.v.22-58) and marginally low serum copper (0.6 ?g/mL-n.v.0.7-1.4). A diagnosis of Wilson’s disease was established. The patient’s chest radiograph, however, showed enlarged pulmonary hili which were confirmed, by computed tomography, to represent enlarged lymph nodes. The patient’s angiotensin converting enzyme was 72.2 U/L (n.v. 12-68), spirometry was normal (FEV1: 87%, FVC: 88%, Dlco: 81%, FRC: 89%, RV: 82%, TLC: 84%) and she did not have considerable hemoglobin desaturation during a six-minute walk test (97% to 96%, distance walked: 360 m). A bronchoalveolar lavage was performed: Cells: 0.132×106, alveolar macrophages 44%, lymphocytes 42%, neutrophils 6%, mononuclear 3%, eosinophils 5%. Ratio CD4/CD8: 2.57. ?he patient was started on triethylenetetramine (Trientin) for her primary disease and was followed up for her stage I sarcoidosis. Three years later she remains clinically stable with no respiratory symptoms, with unchanged findings from spirometry and computed tomography regarding sarcoidosis. The coexistence of these two diseases is rare. Only one similar case has been reported. It concerned a forty-three year-old male, who presented with symptoms and signs of cirrhosis and no neurologic symptoms. He had been diagnosed with sarcoidosis nine years earlier and been treated with corticosteroids. Conclusions The existence of one rare disease should not deter the search towards a coexisting disease if signs and symptoms are not compatible with the first one.

Markopoulou, Aikaterini; Aggelis, Nikolaos; Vlahopoulos, Dimitrios; Peglidou, Valentini; Kalliolou, Eirini; Arnaoutoglou, Marianthi; Kalaitzidou, Eftychia

2012-01-01

284

A Spinal Arteriovenous Fistula in a 3-Year Old Boy  

PubMed Central

We present a case of a 3-year-old boy with neurodegeneration. Family history reveals Rendu-Osler-Weber disease. Magnetic resonance imaging (MRI) of the spinal cord and spinal angiography showed a spinal arteriovenous fistula with venous aneurysm, causing compression of the lumbar spinal cord. Embolisation of the fistula was executed, resulting in clinical improvement. A week after discharge he was readmitted with neurologic regression. A second MRI scan revealed an intraspinal epidural haematoma and increase in size of the aneurysm with several new arterial feeders leading to it. Coiling of the aneurysm and fistulas was performed. Postoperative, the spinal oedema increased despite corticoids, causing more extensive paraplegia of the lower limbs and a deterioration of his mental state. A laminectomy was performed and the aneurysm was surgically removed. Subsequently, the boy recovered gradually. A new MRI scan after two months showed less oedema and a split, partly affected spinal chord. This case shows the importance of excluding possible arteriovenous malformations in a child presenting with progressive neurodegeneration. In particular when there is a family history for Rendu-Osler-Weber disease, scans should be performed instantly to rule out this possibility. The case also highlights the possibility of good recovery of paraplegia in paediatric Rendu-Osler-Weber patients.

Crijnen, Thomas E. M.; Voormolen, Maurits H. J.; Robert, Dominique; Jorens, Philippe G.; Ramet, Jose

2014-01-01

285

Synchronous bilateral breast cancer in a male.  

PubMed

Male breast cancer, which represents only 1% of all breast cancers, is occasionally associated with a family history of breast cancer. Sporadic male breast cancers presenting with another primary breast cancer are extremely rare. In this article, we report on a 70-year-old male patient with bilateral multifocal and synchronous breast cancer and without a family history of breast cancer. PMID:24319497

Rubio Hernández, María Caridad; Díaz Prado, Yenia Ivet; Pérez, Suanly Rodríguez; Díaz, Ronald Rodríguez; Aleaga, Zaili Gutiérrez

2013-01-01

286

Four Years Old, One Eye, Pars Planitis and Cataract: Surgical Challenges Give Challenging Surprises  

PubMed Central

Pars planitis (PP) is an intermediate form of uveitis, which, if left untreated, can result in vision loss. Although phacoemulsification with IOL implantation in eyes with PP often results in improved vision, it represents a surgical challenge due to inflammatory sequelae and the possibility of postoperative complications. This case report describes a 4-year-old male who was admitted for poor visual acuity and severe photophobia. The patient previously received vitreo-retinal surgery on his right eye due to an ‘unknown disease’. Ophthalmological evaluation revealed NLP, pupillary seclusion and band keratopathy in the right eye; echographic scans revealed funnel retinal detachment. The left eye had a visual acuity of CF at 1 foot, minimal band keratopathy, posterior synechiae and the following echographic findings: abundant vitreous opacities and increased chorioretinal thickness (1.6 mm). Complete medical and laboratory assessments found no infectious pathologies. The patient was diagnosed with PP. Anti-inflammatory and immunological therapy was given in order to control inflammation. Within four months, the inflammation was controlled. Slow motion phacoemulsification with iris-retractors was performed. During the surgery, an unexpected challenge was identified: an opaque-vascular retrolental membrane. The membrane was cauterized with diathermy. Primary posterior capsulotomy and membranectomy were performed, followed by a limited anterior vitrectomy. An in-the-bag IOL was implanted successfully, with no postoperative complications, and visual acuity improved to 20/200.

Garcia-Rojas, Leonardo; Matiz-Moreno, Humberto; Chavez-Mondragon, Eduardo

2013-01-01

287

A 30 year old man with an acute presentation of a cerebellopontine angle lesion.  

PubMed

Schwannomas are slow-growing tumors with symptoms manifesting progressively. We report the case of a patient who manifested a sudden loss of consciousness as clinical presentation of an intracranial schwannoma with no acute hemorrhage or hydrocephalus. A 30-year-old male presented comatose and posturing. Cerebral CT revealed an extra-axial lesion with a heterogeneous enhancement and a cystic component located on the right cerebellopontine angle (CPA), displacing the brain stem. No acute hemorrhage or hydrocephalus was documented. Through a retrosigmoid suboccipital craniotomy, an extended subtotal tumor resection was performed. The patient experienced no functional hearing impairment and resumed his daily-life activities 3 months after surgery. Histopathological examination was compatible with a benign schwannoma. An exuberant lymphoplasmacytic infiltrate was found in many areas, signing the presence of an unusual inflammatory reaction with adjacent important intratumoral edema. We propose that the exuberant inflammatory infiltrate and the associated intratumoral edema acted as determining elements in the increase of mass effect and sudden clinical deterioration. PMID:23432651

McLaughlin, Nancy; Berthelet, France; Bojanowski, Michel W

2013-03-01

288

Burkholderia gladioli - a predictor of poor outcome in cystic fibrosis patients who receive lung transplants? A case of locally invasive rhinosinusitis and persistent bacteremia in a 36-year-old lung transplant recipient with cystic fibrosis  

PubMed Central

There have been very few reports describing postlung transplant outcomes in patients’ infected/colonized with Burkholderia gladioli pretransplant. A case involving a lung transplant recipient with cystic fibrosis who ultimately died as a result of severe rhinosinusitis due to B gladioli infection in the context of postlung transplant immunosuppression is reported.

Quon, Bradley S; Reid, James D; Wong, Patrick; Wilcox, Pearce G; Javer, Amin; Wilson, Jennifer M; Levy, Robert D

2011-01-01

289

Burkholderia gladioli - a predictor of poor outcome in cystic fibrosis patients who receive lung transplants? A case of locally invasive rhinosinusitis and persistent bacteremia in a 36-year-old lung transplant recipient with cystic fibrosis.  

PubMed

There have been very few reports describing postlung transplant outcomes in patients' infected?colonized with Burkholderia gladioli pretransplant. A case involving a lung transplant recipient with cystic fibrosis who ultimately died as a result of severe rhinosinusitis due to B gladioli infection in the context of postlung transplant immunosuppression is reported. PMID:22059186

Quon, Bradley S; Reid, James D; Wong, Patrick; Wilcox, Pearce G; Javer, Amin; Wilson, Jennifer M; Levy, Robert D

2011-01-01

290

A Case of Premature Ovarian Failure in a 33-Year-Old Woman  

PubMed Central

Objective. To assess aetiology of a POF in a 33-year-old woman and, if possible, plan a cure. Design. Case report. Setting. medical genetics diagnostic unit in a university hospital. Patient. A 33-year-old woman with premature ovarian failure (POF). Intervention(s). Genetic counseling, karyotyping, FISH study. Result(s). Turner-like diagnosis. Conclusion(s). Most cases of POF remain idiopathic. Turner syndrome can occur in very different phenotypes; cytogenetic and molecular profiling can provide a definitive diagnosis in cases with nonclassical phenotype.

Colao, Emma; Granata, Teresa; Vismara, Marco F. M.; Bombardiere, Francesco; Nocera, Donatella; Luciano, Elisa; Perrotti, Nicola; Malatesta, Paola

2013-01-01

291

The First Report of Fetal Alcohol Effect in a 12 Year-Old Child in Korea  

PubMed Central

We present the first report of fetal alcohol effect in a 12 year-old child in Korea. The mother had consumed 162 g of alcohol per week continuously during pregnancy. His first febrile seizure occurred before he was 1 year old, and became more frequent 2 years later. He started showing signs of right paraplegia when he was 3.5 years old and brain MRI revealed periventricular leucomalacia near the left ventricle. He was microcephalic and his growth was retarded. He was irritable, impatient, impulsive, and inattentive, and showed disinterest in school activities and aggressive and dangerous behavior. After the diagnosis of attention deficit/hyperactivity disorder was made, psychopharmacological treatment and family support was initiated. After 10 months, he still had intermittent ideas of reference, although the aggressive behavior, inattentiveness, and impulsivity had improved. Using this case study, we stress the importance of maternal alcohol history in patients with these characteristics.

Ahn, Dong Hyun; Lee, Young Jin; An, Ho Young; Ahn, Joon Ho

2009-01-01

292

A Two-Year-Old with Rickets: Diet History, Treatment and Follow-Up  

Microsoft Academic Search

AJ, a 2-year-old African-American male, was referred to a nutrition and gastroenterology clinic with the diagnosis of rickets and iron deficiency anemia, both of which were secondary to poor nutrition. All of the classic signs of rickets were present: frontal bossing, rachitic rosary, enlarged joints, and bowed legs with the latter condition making it impossible for AJ to walk without

K. R. Kramer; S. M. Phillips; J. Radcliffe

1998-01-01

293

Risk Factors for Speech Delay of Unknown Origin in 3YearOld Children  

Microsoft Academic Search

One hundred 3-year-olds with speech delay of unknown origin and 539 same-age peers were compared with respect to 6 variables linked to speech disorders: male sex, family history of developmental communication disorder, low maternal education, low socioeconomic status (indexed by Medicaid health insurance), African American race, and prolonged otitis media. Abnormal hearing was also examined in a subset of 279

Thomas F. Campbell; Christine A. Dollaghan; Howard E. Rockette; Jack L. Paradise; Heidi M. Feldman; Lawrence D. Shriberg; Diane L. Sabo; Marcia Kurs-Lasky

2003-01-01

294

Photobacterium damsela wound infection in a 14-year-old surfer.  

PubMed

Photobacterium damsela (P damsela) is a common marine bacterium. Rare reports of P damsela causing septicemia and wound infection have been described in children. We report a case of Photobacterium damsela isolated from a wound culture taken from a 14-year-old male injured after a minor trauma while surfing. We alert physicians to this infection and the importance of early diagnosis and appropriate antimicrobial therapy for wound infection following seawater injury. PMID:19279534

Aigbivbalu, Lem; Maraqa, Nizar

2009-04-01

295

A dispermic chimerism in a 2-year-old Caucasian boy  

Microsoft Academic Search

Detection of two different cell populations in a child is a rare event. The following case of a dispermic chimera was diagnosed\\u000a before surgery due to problems in blood group determination. A 2-year-old phenotypically male child was admitted for correction\\u000a of a penoscrotal hypospadia and unilateral cryptorchism. During presurgical laboratory investigation, difficulties in blood\\u000a group determination occurred. Blood group typing

L. M. Repas-Humpe; A. Humpe; R. Lynen; B. Glock; E. M. Dauber; G. Simson; W. R. Mayr; M. Köhler; S. Eber

1999-01-01

296

Sentinel lymph node biopsy in male breast cancer patients  

Microsoft Academic Search

The concept of sentinel node biopsy has been validated for female breast cancer patients whereas, ALND remains the standard of care for male breast cancer patients with similar tumours. We evaluated the results of SLN biopsy in male breast cancer patients with clinically negative axillae.This study included all male breast cancer patients who underwent SLN biopsy between February 1998 and

A. Goyal; K. Horgan; M. Kissin; C. Yiangou; M. Sibbering; M. Lansdown; R. G. Newcombe; R. E. Mansel

2004-01-01

297

Perivascular epithelioid cell tumour of the vagina in an 8 year old girl  

Microsoft Academic Search

Perivascular epithelioid cell tumor (PEComa) is a rare mesenchymal tumor with an unpredictable natural history. We present the first reported case of PEComa of the vagina diagnosed in an 8-year-old girl. This was initially diagnosed on biopsy as an embryonal rhabdomyosarcoma, and the patient underwent 3 cycles of chemotherapy according to the Mesenchymal Malignant Tumour 1989 protocol. A repeat scan,

Lin Yin Ong; Wei Sek Hwang; Adelina Wong; Mei Yoke Chan; Chan Hon Chui

2007-01-01

298

Orbital Rosai-Dorfman Disease in a Five-Year-Old Boy  

PubMed Central

Rosai–Dorfman disease (RDD) is characterized by histiocytic proliferation and massive cervical lymphadenopathy, although some patients have extra-nodal involvement. We report a case of extranodal RDD in a five-year-old child, initially misdiagnosed as orbital inflammatory disease and treated with oral steroids. A subsequent orbital biopsy three years later confirmed the diagnosis of Rosai Dorfman disease.

Al-Moosa, Ashref J.; Behbehani, Raed S.; Hussain, Abdulmohsen E.; Ali, Abdullah E.

2011-01-01

299

Type 3 GM I gangliosidosis: clinical and neuroradiological findings in an 11-year-old girl  

Microsoft Academic Search

An 11-year-old Japanese girl was diagnosed as having type 3 GM1 gangliosidosis by clinical symptoms and enzyme assay. She was the youngest among the patients with type 3 GM 1 gangliosidosis whose clinical and neuroradiological findings have been documented. Clumsiness since early infancy and dystonia since early childhood which progressed slowly without mental deterioration and dysmorphism led us to the

Rieko Tanaka; Toru Momoi; Akira Yoshida; Mitsuyoshi Okumura; Shinji Yamakura; Yoshinori Takasaki; Takahiro Kiyomasu; Chutaro Yamanaka

1995-01-01

300

An isolated renal hydatid cyst in a 6-year-old child: A rare case report  

PubMed Central

Isolated involvement of the kidney is rare in hydatid disease and is even rarer in children. We present a case of primary right renal hydatid cyst in 6-year-old female child who presented with pain right flank of 4 months duration. The patient was managed by nephrectomy.

Sarmast, Arif Hussain; Sherwani, Afak Yusuf; Dangroo, Sajad Ahmed; Wani, Mohd. Saleem; Hamid, Arif; Showkat, Hakim Irfan

2014-01-01

301

Persistent Hyperplastic Primary Vitreous Humor; a Finding in a 71-Year Old Man.  

National Technical Information Service (NTIS)

The number of reported patients with eyes affected with persistent hyperplastic primary vitreous humor (PHPV) who have survived into adolescent or early adult years is very small. The finding of a case of PHPV in a 71-year-old man is exceptional and promp...

A. G. Spaulding

1968-01-01

302

Thigh Pain in a Ten-Year-Old Boy  

PubMed Central

The ability to obtain a good history is still an essential skill, but various unforeseen obstacles can mislead the physician. In the case described, a ten-year-old boy was unable to give an accurate history without his parents present. Then, his parents seemed relatively unconcerned about some fairly dramatic symptoms. Finally, even after the full history was obtained, there was a further two-month delay in making the correct diagnosis because it was so unlikely in a ten-year-old.

Annen, A. Albert

1983-01-01

303

Safety and tolerability of the novel inhaled corticosteroid fluticasone furoate in combination with the ?2 agonist vilanterol administered once daily for 52 weeks in patients >=12 years old with asthma: a randomised trial  

PubMed Central

Background The inhaled corticosteroid fluticasone furoate (FF) in combination with the long-acting ?2 agonist vilanterol (VI) is in development for asthma and chronic obstructive pulmonary disease. Objective To assess the safety and tolerability of FF/VI over 52?weeks in patients with asthma. Methods Patients (aged ?12?years; on inhaled corticosteroid) were randomised (2:2:1) to FF/VI 100/25?µg or FF/VI 200/25?µg once daily in the evening, or fluticasone propionate (FP) 500?µg twice daily. Safety evaluations included adverse events (AEs), non-fasting glucose, potassium, 24-h urinary cortisol excretion, ophthalmic assessments, heart rate and pulse rate. Results On-treatment AEs were similar across groups (FF/VI 66–69%; 73% FP). Oral candidiasis/oropharyngeal candidiasis was more common with FF/VI (6–7%) than FP (3%). Twelve serious AEs were reported; one (worsening hepatitis B on FP) was considered drug related. Statistically significant cortisol suppression was seen with FP compared with both FF/VI groups at Weeks 12 and 28 (ratios [95% CI] to FP ranged from 1.43 [1.11 to 1.84] to 1.67 [1.34 to 2.08]; p?0.006), but not at Week 52 (ratios to FP were 1.05 [0.83 to 1.33] for FF/VI 100/25?µg and 1.09 [0.87 to 1.38] for FF/VI 200/25?µg). No clinically important changes in non-fasting glucose, potassium, QT interval corrected using Fridericia's formula (QTc[F]) or ophthalmic assessments were reported. Pulse rate (10?min post dose [Tmax], Week 52) was significantly increased with FF/VI versus FP (3.4?bpm, 95% CI 1.3 to 5.6; p=0.002 [FF/VI 100/25?µg]; 3.4?bpm, 95% CI 1.2 to 5.6; p=0.003 [FF/VI 200/25?µg]). Mean heart rate (24-h Holter monitoring) decreased from screening values in all groups (0.2–1.1?bpm FF/VI vs 5?bpm FP; Week 52). Conclusions FF/VI (100/25?µg or 200/25?µg) administered once daily over 52?weeks was well tolerated by patients aged ?12?years with asthma. The overall safety profile of FF/VI did not reveal any findings of significant clinical concern. ClinicalTrials.gov NCT01018186

Busse, William W; O'Byrne, Paul M; Bleecker, Eugene R; Lotvall, Jan; Woodcock, Ashley; Andersen, Leslie; Hicks, Wesley; Crawford, Jodie; Jacques, Loretta; Apoux, Ludovic; Bateman, Eric D

2013-01-01

304

Simvastatin-induced dermatomyositis in a 50-year-old man.  

PubMed

Dermatomyositis (DM) is a rare inflammatory autoimmune disease for which an iatrogenic origin has been described in a few cases. The authors report a case of DM occurring after simvastatin intake. A 50-year-old male sought medical attention for a photodistributed rash and considerable muscular weakness present for 3 months. One year earlier, simvastatin had been introduced. Serum creatine kinase levels were elevated. Histological examination of a muscle biopsy was consistent with a diagnosis of DM. Investigation for neoplasia and associated autoimmune disease proved negative. All clinical and laboratory abnormalities diminished corticosteroid therapy (1 mg/kg/day). Case reports have suggested that lipid-lowering drugs, especially statins, could induce or reveal chronic muscle diseases. In statins myopathy, reduction of coenzyme Q has been discussed as a key mechanism. Our case of DM in a patient receiving simvastatin adds to the previous reported cases in the literature and highlights the potential role of statins as triggers of immune systemic diseases. PMID:22700482

Zaraa, Inés Rania; Labbène, Imen; Mrabet, Dalila; Zribi, Hela; Chelly, Inès; Zitouna, Mohamed; Mokni, Mourad; Sellami, Slaheddine; Ben Osman, Amel

2011-01-01

305

[19-year-old kick-boxer with hematemesis and splenomegaly].  

PubMed

Traumatic portal vein thrombosis is a rare cause of nonmalignant, noncirrhotic portal hypertension. We report a case of a 19-year old patient, who presented with variceal bleeding and splenomegaly. Diagnosis was based on the history of kickboxing and an otherwise negative etiological investigation. The patient underwent endoscopic therapy and portosystemic shunt operation (Warren-shunt) due to cavernous transformation and severe hypersplenism. Thereafter the patient remained asymptomatic. PMID:19771406

Wobser, H; Schölmerich, J; Büttner, R

2010-02-01

306

Clear cell adenocarcinoma of the renal pelvis in a male patient.  

PubMed

Carcinoma of the renal pelvis is an uncommon renal neoplasm. Clear cell adenocarcinoma in the urinary tract is rare and has a histomorphology resembling that of the female genital tract. We herein present a case of clear cell adenocarcinoma of the renal pelvis, which is the first example in a male patient to our knowledge. A 54-year-old man presented with right flank pain. The tumor was associated with renal stones and hydronephrosis and invaded into the peripelvic fat tissue with regional lymph node metastasis. The patient died of metastatic disease six months postoperatively. Histologically, the tumor showed complex papillary architecture lined with clear and hobnail cells. Clear cell adenocarcinoma of the renal pelvis may pose a diagnostic challenge on histological grounds, particularly in the distinction from renal cell carcinoma. The immunohistochemical stains could help confirm the diagnosis. Due to its rarity, an effective treatment regimen remains to be determined. PMID:24455377

Kongkarnka, Sarawut; Kitirattakarn, Pruit; Katayama, Hironori; Khunamornpong, Surapan

2013-01-01

307

The Passive in 3- and 4-Year-Olds  

ERIC Educational Resources Information Center

This paper argues that analyzing the patterns of individual subject performance in tests of comprehension of passives might give insight into how little children interpret passives: 3 and 4 year-olds seem to go through a range of passive interpretation, that varies from actual comprehension to total non-comprehension. The fact that some small…

de Barros Pereira Rubin, Maraci Coelho

2009-01-01

308

[A 15-year old boy with abdominal pain].  

PubMed

A 15-year-old boy came to the emergency department with abdominal pain in the left lower quadrant. The medical history included surgery for malrotation of bowel in two of his brothers. A CT-abdomen showed malrotation of the colon with a left-sided appendicitis and polysplenia. An emergency laparoscopic appendectomy was performed. Recovery was uneventful. PMID:24618236

Raats, Jelle W; Donker, Jeroen M W; van der Laan, Lijckle

2014-01-01

309

Infections in children under 5 years old and latrine cleanliness  

Microsoft Academic Search

The aim of this study is to assess the cleanliness of the latrine and its relation to occurrence of disease in children under 5 years old. A stratified random sample of 1327 households was conducted in 11 villages in Upper Egypt. It included a sub-sample of 541 children under 5 years living in households with latrines. The latrine cleanliness was

Salma Galal; Chitra Sundaram; Nahed Hassan; Kamelia Salem; Somia Lashin

2001-01-01

310

Balancing on a Slackline: 8-Year-Olds vs. Adults  

PubMed Central

Children are less stable than adults during static upright stance. We investigated whether the same holds true for a task that was novel for both children and adults and highly dynamic: single-legged stance on a slackline. We compared 8-year-olds with young adults and assessed the following outcome measures: time on the slackline, stability on the slackline (calculated from slackline reaction force), gaze movement, head-in-space rotation and translation, trunk-in-space rotation, and head-on-trunk rotation. Eight-year-olds fell off the slackline quicker and were generally less stable on the slackline than adults. Eight-year-olds also showed more head-in-space rotation and translation, and more gaze variability around a visual anchor point they were instructed to fixate. Trunk-in-space and head-on-trunk rotations did not differ between groups. The results imply that the lower postural stability of 8-year-olds compared to adults – as found in simple upright stance – holds true for dynamic, novel tasks in which adults lack the advantage of more practice. They also suggest that the lack of head and gaze stability constitutes an important limiting factor in children’s ability to master such tasks.

Scharli, Andrea Melanie; Keller, Melanie; Lorenzetti, Silvio; Murer, Kurt; van de Langenberg, Rolf

2013-01-01

311

Balancing on a Slackline: 8-Year-Olds vs. Adults.  

PubMed

Children are less stable than adults during static upright stance. We investigated whether the same holds true for a task that was novel for both children and adults and highly dynamic: single-legged stance on a slackline. We compared 8-year-olds with young adults and assessed the following outcome measures: time on the slackline, stability on the slackline (calculated from slackline reaction force), gaze movement, head-in-space rotation and translation, trunk-in-space rotation, and head-on-trunk rotation. Eight-year-olds fell off the slackline quicker and were generally less stable on the slackline than adults. Eight-year-olds also showed more head-in-space rotation and translation, and more gaze variability around a visual anchor point they were instructed to fixate. Trunk-in-space and head-on-trunk rotations did not differ between groups. The results imply that the lower postural stability of 8-year-olds compared to adults - as found in simple upright stance - holds true for dynamic, novel tasks in which adults lack the advantage of more practice. They also suggest that the lack of head and gaze stability constitutes an important limiting factor in children's ability to master such tasks. PMID:23626583

Schärli, Andrea Melanie; Keller, Melanie; Lorenzetti, Silvio; Murer, Kurt; van de Langenberg, Rolf

2013-01-01

312

The Structure of Executive Function in 3-Year-Olds  

ERIC Educational Resources Information Center

Although the structure of executive function (EF) during adulthood is characterized by both unity and diversity, recent evidence suggests that preschool EF may be best described by a single factor. The latent structure of EF was examined in 228 3-year-olds using confirmatory factor analysis. Children completed a battery of executive tasks that…

Wiebe, Sandra A.; Sheffield, Tiffany; Nelson, Jennifer Mize; Clark, Caron A. C.; Chevalier, Nicolas; Espy, Kimberly Andrews

2011-01-01

313

Rhinoscleroma in a 5-year-old Portuguese Child.  

PubMed

Rhinoscleroma is a chronic granulomatous infectious disease that is rare in Western Europe. We report the case of a 5-year-old Portuguese boy diagnosed with rhinoscleroma in the context of recurrent epistaxis. He had a 6-month course of antibiotic (amoxicillin plus clavulanate) therapy with full recovery. PMID:24445824

Simão, Inês; Gaspar, Iuri; Faustino, Rosário; Brito, Maria João Rocha

2014-07-01

314

Meaning from Syntax: Evidence from 2-Year-Olds  

ERIC Educational Resources Information Center

When toddlers view an event while hearing a novel verb, the verb's syntactic context has been shown to help them identify its meaning. The current work takes this finding one step further to reveal that even in the absence of an accompanying event, syntactic information supports toddlers' identification of verb meaning. Two-year-olds were first…

Arunachalam, Sudha; Waxman, Sandra R.

2010-01-01

315

Two-Year-Olds Compute Syntactic Structure On-Line  

ERIC Educational Resources Information Center

Syntax allows human beings to build an infinite number of new sentences from a finite stock of words. Because toddlers typically utter only one or two words at a time, they have been thought to have no syntax. Using event-related potentials (ERPs), we demonstrated that 2-year-olds do compute syntactic structure when listening to spoken sentences.…

Bernal, Savita; Dehaene-Lambertz, Ghislaine; Millotte, Severine; Christophe, Anne

2010-01-01

316

Emerging Understanding of Patterning in 4-Year-Olds  

ERIC Educational Resources Information Center

Young children have an impressive amount of mathematics knowledge, but past psychological research has focused primarily on their number knowledge. Preschoolers also spontaneously engage in a form of early algebraic thinking-patterning. In the current study, we assessed 4-year-old children's knowledge of repeating patterns on two occasions…

Rittle-Johnson, Bethany; Fyfe, Emily R.; McLean, Laura E.; McEldoon, Katherine L.

2013-01-01

317

Assessing Mastery Motivation in 7- and 10-Year Olds.  

ERIC Educational Resources Information Center

This study examined the reliability and construct validity of two types of measures of mastery motivation for elementary school children: a new version of the Dimensions of Mastery Questionnaires (DMQ) and behavioral mastery tasks. Participating were 64 mostly middle class and Caucasian 7- and 10-year-olds living in a middle-sized western city.…

Morgan, George A.; Bartholomew, Sheridan

318

Radiation Myelitis in a 5YearOld Girl  

Microsoft Academic Search

Myelopathy is an uncommon complication of radiotherapy, particularly in the pediatric age group. A 5-year-old girl with acute lymphoblastic leukemia developed a severe but transient radiculopathy after intrathecal administration of methotrexate and cytarabine for an isolated central nervous system relapse. Chemotherapy was then given through an intraventricular catheter. Owing to a second central nervous system recurrence, she was treated with

Nuno Lobo Antunes; Susan Wolden; Mark M. Souweidane; Eric Lis; Marc Rosenblum; Peter G. Steinherz

2002-01-01

319

Hypersexuality in a 28YearOld Woman with Rabies  

Microsoft Academic Search

Unusual clinical presentations of rabies are well known. A case of rabies is reported in a 28-year-old female who presented\\u000a with features of increased sexual desire and heightened sexual arousal without provocation. Health care providers should be\\u000a aware that marked changes in sexual behavior may be related to infection due to rabies.

Subramanian Senthilkumaran; Namasivayam Balamurgan; Shah Sweni; Ritesh G. Menezes; Ponniah Thirumalaikolundusubramanian

320

Friendships among 4 & 5 Year Olds in Day Care.  

ERIC Educational Resources Information Center

This study involved observation of 4- and 5-year-olds in a day care setting, focusing on how they developed and maintained friendships with other children in day care. Children were observed twice a day for 3 weeks as they engaged in outdoor play, dramatic play, and manipulative play. Observations included which children played with each other and…

Amiker, Samantha

321

Apraxia of speech in healthy 36-year-old man.  

PubMed

A 36-year-old healthy man presented with sudden onset speech difficulty. Thorough clinical examination revealed interesting deficits suggestive of apraxia of speech. He was found to have an infarct in his frontal region explaining the deficits. We have undertaken clinical evaluation and differential diagnoses of this condition. PMID:23628441

Ramos-Estebanez, Ciro; Gokhale, Sankalp; Goddeau, Richard; Kumar, Sandeep

2013-08-01

322

Similarity Predicts Liking in 3-Year-Old Children  

ERIC Educational Resources Information Center

Two studies examined the influence of similarity on 3-year-old children's initial liking of their peers. Children were presented with pairs of childlike puppets who were either similar or dissimilar to them on a specified dimension and then were asked to choose one of the puppets to play with as a measure of liking. Children selected the puppet…

Fawcett, Christine A.; Markson, Lori

2010-01-01

323

Two-Year-Old Children Interpret Abstract, Purely Geometric Maps  

ERIC Educational Resources Information Center

In two experiments, 2.5-year-old children spontaneously used geometric information from 2D maps to locate objects in a 3D surface layout, without instruction or feedback. Children related maps to their corresponding layouts even though the maps differed from the layouts in size, mobility, orientation, dimensionality, and perspective, and even when…

Winkler-Rhoades, Nathan; Carey, Susan C.; Spelke, Elizabeth S.

2013-01-01

324

Mathematics Skills of Nine-Year-Olds: 1978 to 2004  

ERIC Educational Resources Information Center

Using recently released data from the Long-Term Trend Assessment of the National Assessment of Educational Progress, this study analyzed the mathematics performance of 9-year-old students between 1978 and 2004. The study goes beyond overall results by describing the assessment items and the change over time on each of those items. The data…

Kloosterman, Peter

2011-01-01

325

A Speech Screening Procedure with Three-Year-Old Children  

ERIC Educational Resources Information Center

Perinatal histories and developmental data for the first year of life were examined for 46 children who failed a screening test for use by nonprofessional interviewers in the home situation for evaluation of language and speech development in 3-year-old children. (Author/KW)

Fiedler, Miriam F.; And Others

1971-01-01

326

A 54-year-old woman with degenerative back pain  

Microsoft Academic Search

Back pain is a common symptom: up to 70% of UK adults experience this symptom by the age of 60 and most have moderate to severe pain. Back pain accounted for 12% of consultations to traditional acupuncturists in 2001 and is one of the most common reasons for consultation with an acupuncturist. This case report concerns a 54-year-old woman with

Claire M Tuck

2010-01-01

327

Headshaking in a 10-year-old Thoroughbred mare.  

PubMed

A 10-year-old Thoroughbred mare was presented with a 2.5-week history of headshaking. Based on a thorough physical examination, blood analysis, and a fine needle aspirate of an enlarged thyroid gland, a tentative diagnosis of seasonal idiopathic headshaking was made. Treatment with cyproheptadine was attempted. PMID:15025153

Bell, Angela J M

2004-02-01

328

Headshaking in a 10-year-old Thoroughbred mare  

PubMed Central

Abstract A 10-year-old Thoroughbred mare was presented with a 2.5-week history of headshaking. Based on a thorough physical examination, blood analysis, and a fine needle aspirate of an enlarged thyroid gland, a tentative diagnosis of seasonal idiopathic headshaking was made. Treatment with cyproheptadine was attempted.

2004-01-01

329

Smoking and drinking among 16-year-olds  

Microsoft Academic Search

AS part of a longitudinal study of 16-year-olds, ques tions were asked concerning smoking and drinking behaviour. Comparisons with previous data indi cated a general decline in smoking, though less so for girls than boys, and the former are now more frequent smokers than boys. Drinking alcohol was at about the same frequency as 11 years ago, and social class

M. T. Taylor; G. D. Mardle

1986-01-01

330

Acquired stuttering in a 16-year-old boy  

Microsoft Academic Search

This case study describes a 16-year-old boy who started to stutter after a rotavirus infection followed by signs suggestive of a cerebellar encephalitis. It illustrates the fact that acquired stuttering can be observed in younger children and that it may be difficult to distinguish neurogenic from psychogenic forms of acquired stuttering in some cases. This is especially true following a

Catherine Theys; Astrid van Wieringen; Luc Tuyls; Luc De Nil

2009-01-01

331

A Three Year Old Learning Literacy at Home  

Microsoft Academic Search

This study provides a record of one day of literacy learning at home of a three year old child. It indicates the wide variety of literacy activities which a young child explores and often initiates. The importance of story readings as well as repeated readings of the same book are noted. However, the use of other print at home, songs

Robin Campbell

1998-01-01

332

Concepts of Romance in 15-Year-Old Adolescents.  

ERIC Educational Resources Information Center

Examined 15-year olds' descriptions of dating partners and romance. Dating experiences were brief in duration, though intense in frequency of contact. Affiliative qualities more than attachment qualities characterized their conscious views of romance. Girls were more likely than boys to mention interpersonal qualities, while boys were more likely…

Feiring, Candice

1996-01-01

333

Localized secondary erythromelalgia in an 11-year-old boy.  

PubMed

We report an 11-year-old boy with localized secondary erythromelalgia on his left medial thigh. The episodes responded well to indomethacin and prednisone but recurred after the medications were stopped. The disease was stable after being treated for 5 months. PMID:22612394

Wu, Hui-Hui; Wang, Ming-Jun; Luo, Di-Qing; Lin, Qing

2013-01-01

334

Early Childhood Program Standards for Three and Four Year Olds.  

ERIC Educational Resources Information Center

This document presents the Massachusetts Early Childhood Program Standards and Learning Guidelines for Three- and Four-Year-Olds, required for programs receiving funding through Community Partnerships for Children (CPC). The standards were developed in accord with the accreditation process of the National Association for the Education of Young…

Franklin, Sandra Putnam; Lamana, Annette; Van Thiel, Lisa

335

Erotized Transference in the Male Patient-Female Therapist Dyad  

PubMed Central

Little has been published regarding male patients' erotic transferences to female therapists. It has been suggested that male patients do not develop full erotic transferences and rarely experience erotized transferences. The author presents a case report documenting erotization in a male patient–female therapist dyad and reviews current theories on the etiology, therapeutic significance, and treatment strategies indicated for such a transference.

Koo, Martha B.

2001-01-01

336

Resiliency: A Comparison of Construct Definitions Arising from Conversations with 9 Year Old - 12 Year Old Children and Their Teachers.  

ERIC Educational Resources Information Center

Much research has focused on the concept of resilience, which is defined as the process of, capacity for, or outcome of successful adaptation despite challenging circumstances. To examine resilience in school children, small group interviews were conducted with 9-12 year-old children (N=125) drawn from five primary schools in South Australia. The…

Dryden, John; Johnson, Bruce; Howard, Sue; McGuire, Alex

337

Internet Use and Psychological Well-Being among 10-Year-Old and 11-Year-Old Children  

ERIC Educational Resources Information Center

This paper uses data from the 2009 Kids' Life and Times Survey, involving 3657 children aged 10 or 11 years old in Northern Ireland. The survey indicated high levels of use of Internet applications, including social-networking sites and online games. Using the KIDSCREEN-27 instrument, the data indicate that the use of social-networking sites and…

Devine, Paula; Lloyd, Katrina

2012-01-01

338

[A case of paraganglioma of urinary bladder in a 96-year-old female].  

PubMed

A 96-year-old woman was referred to our hospital with gross hematuria. Cystoscopy, computed tomography and magnetic resonance imaging revealed a submucosal bladder tumor. Incomplete transurethral resection was performed with no intraoperative complications. The histopathological diagnosis of nonmalignant paraganglioma was confirmed by immunohistochemical staining. This patient is the oldest of the 49 patients with paraganglioma of the urinary bladder reported in the Japanese literature. PMID:9086352

Miyata, Y; Furukawa, M; Ootani, H; Higami, Y

1997-02-01

339

A 41-Year-Old Woman with Migratory Panniculitis  

PubMed Central

A 41-year-old woman had two months of intermittent migratory swellings in the trunk, face, and limbs associated with erythema, pruritus, and pain. Laboratory analysis showed moderate eosinophilia. The triad of eosinophilia, migratory lesions (nodular panniculitis), and raw fish consumption was highly suggestive of cutaneous gnathostomiasis. She was successfully treated with albendazole (400 mg twice a day for 21 days) and showed complete and permanent resolution of the lesions.

Vanegas, Edgar S.; Cendejas, Rafael Franco; Mondragon, Arturo

2014-01-01

340

A 41-year-old woman with migratory panniculitis.  

PubMed

A 41-year-old woman had two months of intermittent migratory swellings in the trunk, face, and limbs associated with erythema, pruritus, and pain. Laboratory analysis showed moderate eosinophilia. The triad of eosinophilia, migratory lesions (nodular panniculitis), and raw fish consumption was highly suggestive of cutaneous gnathostomiasis. She was successfully treated with albendazole (400 mg twice a day for 21 days) and showed complete and permanent resolution of the lesions. PMID:24808244

Vanegas, Edgar S; Cendejas, Rafael Franco; Mondragón, Arturo

2014-05-01

341

Painful ulcers in a 5-year-old girl  

Microsoft Academic Search

A 5-year-old girl was admitted to our clinic with several painful ulcers spreading from the right elbow to the armpit. The\\u000a right axillary lymph node was palpable. She was previously treated in another service with oral amoxicillin for 10 days due\\u000a to a diagnosis of impetigo. There was no resolution of the lesion after the treatment, so she looked for another

Maria do Socorro Costa da Silva; Ellem Ramos Ferreira; Leonardo Rodrigues Campos; Márcio Tadeu Vieira Brito; Patricia Ferreira; Rodrigo Silva Grilo

2011-01-01

342

Cosmetic Clitoridectomy in a 33YearOld Woman  

Microsoft Academic Search

The Female Genital Mutilation Act (2003) in England allows for mental health exceptions for cosmetic surgery resulting from\\u000a perceived abnormality. Similar legislation exists in other countries. There are no reported cases of clitoridectomy for cosmetic\\u000a reasons or any discussion in the literature of mental health exceptions to the Act. This is a single case report on a 33-year-old\\u000a married, heterosexual

David Veale; Joe Daniels

343

A five-year-old child with renal hydatidosis.  

PubMed

Hydatidosis is a zoonosis of worldwide distribution caused by the parasite Echinococcus granulosus. Clinical manifestations include cyst formation, most commonly in the liver (67-89%) and lungs (10-15%). Renal localizations are rare. We report a case of renal hydatidosis in a five-year-old child treated in a tertiary pediatric hospital in Argentina. After the diagnosis was made, elective surgery was performed, which led to a rapid recovery. PMID:23897992

Moscatelli, Guillermo; Moroni, Samanta; Freilij, Héctor; Salgueiro, Fabián; García Bournissen, Facundo; Altcheh, Jaime

2013-09-01

344

Isolated tracheoesophageal fistula in a 10-year-old girl  

Microsoft Academic Search

Isolated tracheoesophageal fistula (H-TOF) is a rare type of tracheoesophageal anomaly and is in most cases diagnosed in the\\u000a neonatal period because of choking and cyanosis during feeding. Diagnosis may be delayed even until adulthood because of nonspecific\\u000a and sometimes intermittent symptoms, and because false-negative results of all diagnostic tools are not uncommon. We report\\u000a a 10-year-old child with H-TOF,

Iris De Schutter; Françoise Vermeulen; Elke De Wachter; Caroline Ernst; Anne Malfroot

2007-01-01

345

Solitary intradural fibrochondroma in a 16-year-old boy  

Microsoft Academic Search

The following case report is that of a 16-year-old boy who had a solitary benign intracranial parietal fibrochondroma. He presented with a 2 month history of headache. A cranial CT demonstrated an isodense, non-contrast enhancing, extra-axial lesion with decreased central opacity and flecks of hyperdensity consistent with calcification. MRI revealed a heterogeneous well circumscribed mass which had an increased signal

David J Holthouse; Peter D Robbins; Neville W Knuckey

1999-01-01

346

Micronutrient distribution in 16-year-old maritime pine  

Microsoft Academic Search

Summary Concentrations and contents of the micronutrients Fe, Mn, Zn, Cu, and B were measured in various tree compartments of a 16-year-old stand of maritime pine (Pinus pinaster Soland in Ait.). The micronutrients were actively redistributed within the tree. The longer-lived aerial tissues, trunks and branches, consti- tuted the major micronutrient reservoirs, with the exception of manganese which accumulated in

E. SAUR; J. RANGER; B. LEMOINE; J. GELPE

347

Wegener's granulomatosis in a 16-year-old girl  

Microsoft Academic Search

A 16-year-old African-American girl presented to our institution with a 6-week history of swollen ankles and 5-week history of conjunctival injection. She had previously been treated with antibiotics for suspected lower extremity cellulitis. Bilateral ankle swelling with erythema and episcleritis were remarkable clinical findings. Laboratory investigations showed: normal CBC and differential, ESR 68 mm\\/hr, serum BUN 15 mg\\/dL, and serum

N. Mathur; M. Castro; C. Bowser; H. J. Moallem

2004-01-01

348

PEComa in a 12-year-old boy  

PubMed Central

PEComas (perivascular epithelioid cell tumours) are rare mesenchymal tumours, characterised by epithelioid, clear cell morphology with coexpression of melanocytic and smooth muscle markers. They are usually seen in adult females in a variety of anatomical locations, of which, kidney, lung and the gynaecologic tract are the most common. We present a case of PEComa arising from the kidney of a 12-year-old boy.

Uddin, Zeeshan; Qureshi, Asim; Fatima, Samia; Kayani, Naila

2010-01-01

349

Treatment of a four-year-old victim of incest  

Microsoft Academic Search

A case study describing the use of behavior techniques in the treatment of a four—year—old sexual assault victim is presented. The target behaviors included eating, phobic behaviors, self—injurious behaviors, and comments made about the father (the perpetrator) and the paternal grandmother. The child's mother served as both data collector and therapist. The study demonstrates that child victims can experience a

Judith V. Becker; Linda J. Skinner; Gene G. Abel

1982-01-01

350

Gastrointestinal Cancer Educational Case Series: The History and Management of Complex Cases in GI Oncology. A 72 YearOld Man with Metastatic Gastric Cancer  

Microsoft Academic Search

Introduction  Gastric cancer is the third most common cancer worldwide and the second leading cause of cancer deaths. Appropriate staging\\u000a and treatment options relate to the stage of disease and performance status of the patient.\\u000a \\u000a \\u000a \\u000a \\u000a Case report  Here we present the case of a 72 year old male, with an initial presentation of apparently locally advanced gastric cancer.\\u000a On discovery of metastatic

Elizabeth Smyth; Ghassan K. Abou-Alfa; Maeve Lowery; Ali Shamseddine; Ashwaq Al-Olayan; Mohamed Naghy; Derek Power; Teddy Saliba; David Kelsen; Manish A. Shah

2011-01-01

351

Two-Year-Old with Post-Surgical Hypoglossal Nerve Injury and Obstructive Sleep Apnea  

PubMed Central

Background: Airway patency in both children and adults depends on the tonic and phasic activation of muscles of the tongue and pharynx supplied by the hypoglossal nerve arising at the medullary level Methods/Patient: We report a case of a 2-year-old who after resection of fourth ventricle anaplastic ependymoma developed severe sleep disordered breathing and tongue fasciculation. Results: Polysomnography showed severe obstructive sleep apnea with oxygen desaturation to 33%. Magnetic resonance imaging of the brain showed post-surgical effacement of the dorsal lateral medulla. Conclusions: We postulate that damage to the hypoglossal nerve at the level of the medulla contributed to the patient's severe obstructive sleep apnea. Patient was treated with tracheostomy. Citation: DelRosso LM; Hoque R; Gonzalez-Toledo E. Two-year-old with post-surgical hypoglossal nerve injury and obstructive sleep apnea. J Clin Sleep Med 2014;10(1):97-98.

DelRosso, Lourdes M.; Hoque, Romy; Gonzalez-Toledo, Eduardo

2014-01-01

352

Hypercalcemia in a male-to-female transgender patient after body contouring injections: a case report  

PubMed Central

Introduction Body contouring injections by non-licensed providers are frequently sought out by a subset of the male-to-female transgender community. Although short-term side effects such as pulmonary embolism and injection site infection are well known, long-term consequences of such practices are less well studied. Case presentation Here we describe the case of a 40-year-old African American male-to-female transgender patient who presented to our institution with hypercalcemia and acute renal failure secondary to body contouring injections with industrial strength silicone by non-licensed providers, a decade prior to her visit. Work-up revealed an extensive granulomatous inflammatory process in the injection area resulting in electrolyte abnormalities and kidney injury. The patient’s lab results and symptoms responded well to long-term corticosteroid treatment and correlated with treatment adherence. Conclusion Affected patients can sometimes present with unusual clinical symptoms many years after silicone injections. In a constantly growing transgender community that often utilizes non-licensed providers for silicone injections, the medical community will likely face an increasing number of patients with long-term side effects of such practices. Therefore, it is imperative for physicians to recognize such cases promptly and initiate potentially life-saving treatment.

2014-01-01

353

Anal phyllodes tumor in a male patient: a unique case presentation and literature review  

PubMed Central

Abstract Lesions of anogenital mammary-like glands are rare, and only 44 female cases have been reported. Herein, we describe a particularly rare case of phyllodes tumor of anogenital mammary-like glands in a 41-year-old male presenting anal bleeding. Papillectomy was performed. The excised tumor was circumscribed in shape, and after it was sliced into sections, it was noted that there were leaf-like slits on the surface of cut side. Under the microscope, the tumor was found to be biphasic, with a bland glandular epithelium and low-to-intermediate cellular stroma, which together created the leaf-like slits. Gynecomastoid hyperplasia was evident at the periphery. The epithelium showed immuno-activity for ER, PR(focal), AR, and GCDFP-15. The stromal cells showed positive staining for CD34 and vimentin. The morphology and immunophenotype were similar to benign phyllodes tumors of breast. To the best of our knowledge, this case report represents the first case of phyllodes tumor of anogenital mammary-like glands with gynecomastoid hyperplasia at the periphery in a male patient. To make a diagnosis, we had to differentiate this lesion from hidradenoma papilliferum of skin appendage, phyllodes tumor of ectopic prostatic tissue, and other tumors of anogenital mammary-like glands analogous to the breast tumor (e.g., fibroadenoma phyllodes, periductal stromal sarcoma, and spindle cell carcinoma). While gynecomastia of male breast is usually a result of hormone imbalance, our patient’s tumor did not seem to be related to peripheral hormone status in the anogenital mammary-like glands. Nevertheless, because hormone imbalance has been strongly related to male breast cancer, hormone levels may need to be followed in male patients who have this rare malady. Virtual slides The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1509145815899177

2013-01-01

354

A case report of urethral prolapse in a 38 year old female with 46XY karyotype.  

PubMed

A 38-year old female presented with the acute onset of a vulval mass associated with pain and vaginal bleeding. She is female phenotype but has 46XY karyotype and Complete Androgen Insensitivity Syndrome (CAIS). At 15 years old she had a laparotomy and bilateral orchidectomy. Following admission, an examination under anaesthesia and cystoscopy was performed. A diagnosis of strangulated complete urethral prolapse was made. The lesion was excised with diathermy and the meatal skin was reanastomosed to the urethra. At follow-up, the urethra was well healed. The patient now attends Menopause Clinic for oestrogen-replacement therapy. We hope this case raises awareness of the possibility of urethral prolapse in younger women who are oestrogen deficient. It provides further incentive for compliance with hormone replacement therapy for patients with CAIS following gonadectomy, or other women with premature menopause. PMID:25017598

Watson, Helena; Stasiowska, Ewa

2014-06-01

355

Supraorbital Blowin Fracture Presenting as an Ocular Dystopia in a Nine-Year-Old Girl  

PubMed Central

A 9-year-old girl was referred to a trauma centre with severe head injury. 3D CT scan revealed depressed fracture involving the frontal bone on the right side, right parietal bone, and right superior orbital margin, right lamina papyracea. The frontal table was managed conservatively and open reduction and internal fixation was done for the supraorbital blow in to correct the ocular dystopia. The clinical course, possible mechanism, and management of the patient are discussed.

Nallamothu, Ranganadh; Kallam, Shanmukha Reddy; Gunturu, Srikanth; Singh, Sukumar; Rachalapally, Vijay Kumar

2013-01-01

356

Diaphragmatic hernia in an 8-year-old with Ehlers-Danlos syndrome  

Microsoft Academic Search

Ehlers-Danlos syndrome (EDS) includes a group of connective-tissue disorders characterized by abnormal collagen metabolism.\\u000a The diverse spectrum of this disease and its complications present a distinct challenge to the surgeon. Patients with this\\u000a hereditary disorder may have hyperelastic or fragile skin, poor wound healing, hypermobile joints, clotting abnormalities,\\u000a spontaneous pneumothoraces, recurrent hernias, bowel perforation, and vascular complications. An 8-year-old female

J. L. Iglesias; T. Renard

1998-01-01

357

Neurocysticercosis in a 2-year-old boy infected at home  

PubMed Central

A 2-year-old boy presented with seizures and two parenchymal brain ring-enhancing lesions. Diagnosis of neurocysticercosis was confirmed by positive serology and response to albendazole therapy. The patients's mother was a Taenia solium carrier, who had most likely infected the child through the fecal-oral route. Household contacts should always be investigated in children with neurocysticercosis. Proper identification and treatment of Taenia solium carriers will reduce the risk of further spread of the disease.

Brutto, Oscar H. Del

2012-01-01

358

Imperforate Hymen Presenting as Acute Urinary Retention in A 14-Year-Old Nigerian Girl  

PubMed Central

Acute urinary retention in adolescent females is rare, just like imperforate hymen. We present a case of acute urinary retention secondary to imperforate hymen in a 14-year-old Nigerian girl. Its diagnosis and treatment are discussed with a brief review of literature. We highlight the need for a thorough evaluation in the female patient presenting with acute urinary retention, and also the need to provide better health facilities in rural areas in developing countries such as ours.

Anselm, Obi O.; Ezegwui, Uzor H.

2010-01-01

359

EEG findings in an eleven-year-old girl with mercury intoxication.  

PubMed

An 11-year-old female was seen at our outpatient clinic with a broad variety of symptoms that were due to elemental mercury intoxication. Electromyography and sequential electroencephalography findings obtained at days 2, 36, 88 and 148 are described. The patient was treated with chelation therapy during which she clinically improved considerably. A profound decrease in urinary mercury concentration occurred as well as normalization of the electroencephalogram. PMID:19044221

Setz, J M; van der Linde, A A A; Gerrits, G P J M; Meulstee, J

2008-10-01

360

Pathology Case Study: A 45-Year-Old Female with Acute Liver Failure  

NSDL National Science Digital Library

The University of Pittsburgh School of Medicine's Department of Pathology has compiled a series of case studies to help both students and instructors. In this particular study a 45-year-old female patient is suffering from acute liver failure. The case study provides test results and images along with microscopic photos and description. Clicking on the final diagnosis provides a thorough explanation of the diagnosis and treatment.

Richert, Charles A.

2007-08-11

361

Gonococcal peritonitis diagnosed post laparotomy in a 38-year-old woman: a case report  

PubMed Central

A 38-year-old South African lady with a background history of cervical intra-epithelial neoplasia and recent colposcopy presented to the emergency department with severe abdominal pain. Initial investigations were non-diagnostic and despite empirical antibiotic therapy the patient developed peritonism. Post-laprotomy the diagnosis of severe pelvic inflammatory disease and peritonitis secondary to infection with Neisseria Gonorrhoea was made.

2009-01-01

362

The case of an explanted 16-year-old mitral Carpentier-Edwards pericardial bioprosthesis  

Microsoft Academic Search

We report the case of a mitral Carpentier-Edwards pericardial bioprosthesis that was explanted from a 43-year-old female patient\\u000a because of structural valve deterioration 16 years following implantation. Upon removal, the prosthesis was found to be discolored\\u000a and all leaflets were stiff and hard, showing extensive calcification, pannus overgrowth, leaflet hematoma, and multiple disruptions.\\u000a One leaflet presented a wavy free margin

Hiroomi Murayama; Takashi Watanabe; Takashi Yano; Naoki Kida; Yuki Hatano; Keiji Ohara; Atsukata Kobayashi

2006-01-01

363

Gallbladder torsion-induced emphysematous cholecystitis in a 16-year-old boy  

Microsoft Academic Search

The patient was a 16-year-old boy who had turned to the right rapidly as he fielded a baseball that had come to him quickly.\\u000a Two days after this event, which occurred in July 2004, he was admitted to hospital with repeated vomiting and increasing\\u000a right hypochondralgia. Laboratory examination on admission showed elevation of the white blood count and of serum

Shogo Tanaka; Daisuke Kubota; Kazuki Oba; Sang Hun Lee; Takatsugu Yamamoto; Takahiro Uenishi; Hiromu Tanaka; Shoji Kubo; Mitsuharu Matsuyama

2007-01-01

364

Access by the unaccompanied under-16-year-old adolescent to general practice without parental consent  

Microsoft Academic Search

BackgroundThe views of primary health care providers concerning their willingness to consult with under-16-year-old adolescent patients without the presence of a parent or guardian are not well documented. Many young people believe they have to be aged over 16 years to see their general practitioner (GP) alone. Confidentiality is a major concern for young people. It is important that more

Lin Davies

2003-01-01

365

Pancreatic Panniculitis in an 88YearOld Man with Neuroendocrine Carcinoma  

Microsoft Academic Search

Pancreatic panniculitis is a rare complication that occurs in 0.3–3% of patients with pancreatic diseases. Most of the cases reported to date were associated with adenocarcinoma and acute or chronic pancreatitis. We here present an 88-year-old man who was admitted to our institution with a nonfunctional neuroendocrine carcinoma of the pancreas. He subsequently developed pancreatic panniculitis and arthritis. Treatment with

Jan Christian Preiss; Siegbert Faiss; Christoph Loddenkemper; Martin Zeitz; Rainer Duchmann

2002-01-01

366

Trisomy 18 mosaicism in a 15-year-old boy with normal intelligence and short stature  

SciTech Connect

We report a 15-year-old boy with mosaicism for trisomy 18 and normal intelligence. Approximately 50% of his leukocytes are trisomic. This patient represents the sixth report of an individual with trisomy 18 mosaicism and normal intelligence. Those individuals with trisomy 18 mosaicism and normal intelligence need to be advised of increased risks for offspring with chromosome abnormalities and offered the option of prenatal diagnosis for cytogenetic anomalies. 6 refs.

NONE

1995-05-08

367

Sex differences on the progressive matrices among 15–16 year olds: some data from South Africa  

Microsoft Academic Search

It has been widely asserted that there is no sex difference in mean scores on the Progressive Matrices. This paper presents an alternative theory that a male advantage on the test begins to appear at the age of 15 years. This alternative theory is supported by data for the largest sample hitherto reported consisting of 3979 15–16 year olds in

Richard Lynn

2002-01-01

368

Ductal carcinoma in situ in a 16-year-old adolescent boy with gynecomastia: a case report  

Microsoft Academic Search

Ductal carcinoma in situ (DCIS) of the male breast is rare. Even more rare is the finding of DCIS in association with gynecomastia. After an extensive literature search, only two cases have been reported in the literature, both in adults. Here we present the case of a 16-year-old adolescent boy who presented with pubertal gynecomastia that was treated with bilateral

George M. Wadie; Gregory T. Banever; Kevin P. Moriarty; Richard A. Courtney; Theonia Boyd

2005-01-01

369

NASA Administrator Dan Goldin greets 100-year-old VIP.  

NASA Technical Reports Server (NTRS)

Among the VIPs attending the launch of STS-99 is Captain Ralph Charles (left), standing next to NASA Administrator Dan Goldin. Charles hopes to have his wish fulfilled of watching a Shuttle launch in person. The 100-year-old aviator has experienced nearly a century of flight history, from the Wright Brothers to the Space Program. He took flying lessons from one of the first fliers trained by Orville Wright, first repaired then built airplanes, went barnstorming, operated a charter service in the Caribbean, and worked as a test pilot for the Curtiss Wright Airplane Co. Charles is the oldest licensed pilot in the United States, and is still flying.

2000-01-01

370

Gastroblastoma in a 12-year-old Chinese boy  

PubMed Central

Gastrablastoma is a rare epitheliomesenchymal biphasic tumor of stomach in children and young adults first reported by Miettinen et al in 2009. Five cases have been reported up to date including only one case with the nodal metastasis and distant metastases. With little atypism gastroblastoma is suggested to be a low-grade malignancy. Here we report one case of gastroblastoma in a 12-year-old boy with review of the literature. This is the first case of gastroblastoma in Chinese to our knowledge.

Ma, Yangyang; Zheng, Jicui; Zhu, Haitao; Dong, Kuiran; Zheng, Shan; Xiao, Xianmin; Chen, Lian

2014-01-01

371

Posttraumatic superior ophthalmic vein thrombosis in a 2 years old.  

PubMed

Superior ophthalmic vein thrombosis (SOVT) usually results from inflammatory, infectious, or malignant causes. This case describes a 2-year-old boy with severe prolapsing chemosis and proptosis due to thrombosis of the right superior ophthalmic vein resulting from midfacial and right orbital fractures 1 week after the initial trauma. Magnetic resonance imaging and internal carotid artery angiogram are essential in the diagnosis of SOVT. The literature on issues surrounding this case was reviewed with emphasis on the diagnostic evaluation, differential diagnoses, and management of posttraumatic SOVT. PMID:24488160

Akingbola, Olugbenga A; Shar, Basil; Singh, Dinesh; Frieberg, Edwin; Petrescu, Matei

2014-02-01

372

An 81-year-old gentleman with symptomatic Bochdalek hernia.  

PubMed

An 81-year-old gentleman with congenital polycystic kidney disease presented to his primary care physician with dysphagia, gastroesophageal reflux refractory to medical management, and 11.25 kg weight loss in a 6 mo-period. A barium swallow misdiagnosed a paraesophageal hernia for a Bochdalek hernia. Herein, we highlight how a Bochdalek hernia may be disregarded in the differential diagnosis and how providers can resort to a more common diagnosis, a paraesophageal hernia, which is more frequently encountered in old age and whose radiologic appearance might mimic a Bochdalek hernia. PMID:23894690

Rajput, Mohammed Zak; Fisichella, Piero Marco

2013-07-27

373

Lindane toxicity in a 7 year old boy.  

PubMed

Lindane (gamma-benzene hexachloride) is widely used as a scabicide by general practitioners and dermatologists in Pakistan. We present a case of a 7 year old boy who had suffered from scabies 1 week ago, for which he was prescribed lindane along with other medications by a general practitioner. After 3 application of lindane the child began to experience Grand mal seizures, ataxia, weakness, incoordination and severe burning paresthesias. Lindane is known to cause neurotoxicity and for this it has been recommended as a 2nd line treatment for scabies by FDA. PMID:22455304

Daud, Yousaf; Daud-ur-Rehman; Farooq, Umer

2010-01-01

374

NASA Administrator Dan Goldin greets 10-year-old VIP.  

NASA Technical Reports Server (NTRS)

NASA Administrator Dan Goldin (left) shares a laugh with VIP 10- year-old Jonathan Pierce (right), who is garbed in a protective cooling suit designed by NASA. Behind Goldin is astronaut Doug Wheelock; behind Jonathan is his mother, Penny. Jonathan suffers from erythropoietic protoporphyria, a rare condition that makes his body unable to withstand ultraviolet rays. The suit allows him to be outside during the day, which would otherwise be impossible. Jonathan's trip was funded by the Make-A-Wish Foundation and included a visit to Disney World. He and his family were among a dozen VIPs at KSC to view the launch of STS- 99.

2000-01-01

375

NASA Administrator Dan Goldin greets 10-year-old VIP.  

NASA Technical Reports Server (NTRS)

NASA Administrator Dan Goldin (left) watches as 10-year-old Jonathan Pierce (right), who is garbed in a protective cooling suit designed by NASA, shakes hands with astronaut Dog Wheelock. Behind Jonathan is his mother, Penny. Jonathan suffers from erythropoietic protoporphyria, a rare condition that makes his body unable to withstand ultraviolet rays. The suit allows him to be outside during the day, which would otherwise be impossible. Jonathan's trip was funded by the Make-A-Wish Foundation and included a visit to Disney World. He and his family were among a dozen VIPs at KSC to view the launch of STS-99.

2000-01-01

376

NASA Administrator Dan Goldin greets 10-year-old VIP.  

NASA Technical Reports Server (NTRS)

Ten-year-old Jonathan Pierce (second from right), who is garbed in a protective cooling suit, without the helmet, which was designed by NASA, poses with (left to right) NASA Administrator Dan Goldin, Mrs. Goldin, and astronaut Doug Wheelock. Jonathan suffers from erythropoietic protoporphyria, a rare condition that makes his body unable to withstand ultraviolet rays. The suit allows him to be outside during the day, which would otherwise be impossible. Jonathan's trip was funded by the Make-A-Wish Foundation and included a visit to Disney World. He and his family were among a dozen VIPs at KSC to view the launch of STS- 99.

2000-01-01

377

NASA Administrator Dan Goldin greets 10-year-old VIP.  

NASA Technical Reports Server (NTRS)

NASA Administrator Dan Goldin (left) shares a light moment during his meeting with 10-year-old Jonathan Pierce (right), who is garbed in a protective cooling suit designed by NASA. Behind Goldin is astronaut Doug Wheelock; behind Jonathan is his mother, Penny. Jonathan suffers from erythropoietic protoporphyria, a rare condition that makes his body unable to withstand ultraviolet rays. The suit allows him to be outside during the day, which would otherwise be impossible. Jonathan's trip was funded by the Make-A-Wish Foundation and included a visit to Disney World. He and his family were among a dozen VIPs at KSC to view the launch of STS-99.

2000-01-01

378

NASA Administrator Dan Goldin greets 10-year-old VIP.  

NASA Technical Reports Server (NTRS)

NASA Administrator Dan Goldin (left) listens intently to 10-year- old Jonathan Pierce (right), who is garbed in a protective cooling suit designed by NASA. Behind Goldin is astronaut Doug Wheelock; behind Jonathan is his mother, Penny. Jonathan suffers from erythropoietic protoporphyria, a rare condition that makes his body unable to withstand ultraviolet rays. The suit allows him to be outside during the day, which would otherwise be impossible. Jonathan's trip was funded by the Make-A-Wish Foundation and included a visit to Disney World. He and his family were among a dozen VIPs at KSC to view the launch of STS- 99.

2000-01-01

379

Odontogenic myxoma in a 52-year-old woman.  

PubMed

Odontogenic myxoma (OM) is a rare benign but locally aggressive tumour of the jaws. It is usually seen in the second to third decade of life. Women are more frequently affected than men and it has more predilections for the mandible rather than the maxilla. OM presents as an asymptomatic swelling in most of the cases. Owing to the non-capsulated and aggressive nature of OM, a high rate of recurrence has been reported. Here we present a case of OM in a 52-year-old woman managed by segmental mandibulectomy. Sign of recurrence was seen after 18?months of follow-up. PMID:24859552

Ram, Hari; Mehta, Gagan; Kumar, Manoj; Lone, Parveen

2014-01-01

380

A five years old girl child with Takayasu arteritis.  

PubMed

Takayasu arteritis is a systemic vasulitis of large vessels that mainly involves the aorta and its branches. It normally presents in third decade of life and has rarely been reported in children under 10 years of age. We report here a case of Takayasu arteritis in a 5 years old girl who presented with headache, generalized body swelling, severe hypertension, proteinuria and minimal functioning kidneys. Conventional angiography demonstrated narrowing of descending aorta, right subclavian artery and right common iliac artery. She responded steroids, diuretics, antiplatelets and digoxin and discharged home on maintenance therapy. PMID:24304997

Mahmud, Shahid; Ul Hassan Shah, Syed Awais; Zaman, Syed Qamar; Ali, Salman

2013-12-01

381

JAMA Patient Page: Male Sexual Dysfunction  

MedlinePLUS

... achieving or maintaining an erection) • Premature ejaculation (reaching orgasm [sexual climax] too quickly) • Delayed or inhibited orgasm • Physical abnormalities of the penis DIAGNOSING MALE SEXUAL ...

382

Pharmacologic cardiac resynchronization of a 1-year-old boy with severe left ventricular dysfunction.  

PubMed

Postero-septal accessory pathways (AP) are a rare cause of intraventricular dyssynchrony and severe LV dysfunction in children. Beside the common treatment with radiofrequency ablation of septal substrates we present the case of a successful pharmacologic resynchronization in a 13/12 years old male toddler with Wolff-Parkinson-White syndrome (WPW) and severe LV dysfunction (left ventricular biplane EF of 31 %) due to intraventricular dyssynchrony with septal to posterior wall motion delay (SPWMD) of 350 ms. Interventricular mechanical delay (IVMD) was 65 ms. Using propafenone, pharmacologic cardiac resynchronization could be achieved. Pharmacologic resynchronization should be considered as safe and effective alternative to catheter ablation in very young children. PMID:22484822

Paech, Christian; Flosdorff, Patrick; Gebauer, Roman Antonin

2012-10-01

383

Dermatitis and lymphadenitis resembling juvenile cellulitis in a four-year-old dog.  

PubMed

A four-year-old, entire male toy poodle was presented with a two-and-a-half-week history of ocular discharge progressing to periorbital alopecia, depigmentation, alopecia and ulceration around the muzzle. There was also a haemorrhagic discharge from the ears, pyrexia, lethargy and generalised lymphadenopathy. The clinical, cytological, bacteriological and histopathological findings were consistent with a diagnosis of dermatitis resembling juvenile cellulitis in an adult dog. Glucocorticoid therapy led to rapid resolution of the clinical signs and the dog has remained in remission for two years after cessation of treatment. PMID:15163053

Neuber, A E; van den Broek, A H M; Brownstein, D; Thoday, K L; Hill, P B

2004-05-01

384

Initial presentation of Brucella endocarditis in a previously healthy eighteen-year-old young man.  

PubMed

Brucellosis is a reported endemic in the Middle East, Arabian Peninsula, South Asia, and Central and South America, with a high fatality rate of 80%. We present a case report of Brucella endocarditis in a young 18-year-old male who developed aortic and mitral vegetation, subaortic abscess and mitral leaflet perforation. He was started on antibiotics but his cardiac status rapidly deteriorated and eventually needed a double valve replacement. We would like to share our experience and the challenges we faced in managing this case, which is uncommon, especially in young adults. PMID:23751913

Chowdhury, Mohammed Andaleeb; El Abbassi, Wael; Najeeb, Ahmed; Mansoor, Anoop

2013-01-01

385

A 32-year-old Man with Normokalemic Thyrotoxic Periodic Paralysis  

PubMed Central

Thyrotoxic Periodic Paralysis (TPP) is a rare and life threatening condition commonly occurring in young Asian males. It is characterized by acute paralytic attacks and hypokalemia in association with thyrotoxicosis. Serum potassium levels may be normal in rare cases of TPP. The diagnosis of normokalemic TPP may be overlooked and/or delayed in most cases. Here, we describe a 32-year-old Iranian man with normokalemic TPP misdiagnosed as somatization disorder with the correct diagnosis made one year after the onset of symptoms.

Valizadeh, Neda; Zarrin, Sahar

2013-01-01

386

Anterior cruciate ligament reconstruction in a 75 years old man: a case report with review of literature.  

PubMed

Anterior cruciate ligament (ACL) reconstruction is usually recommended for young patients. Several recent articles have however reported comparable outcomes of ACL reconstruction between youth and patients in fourth or fifth age group. But in the literature there are not many reports about ACL reconstruction in patients over 70 years old. We report a case of a successful arthroscopic ACL reconstruction (using single bundle quadrupled hamstring graft) in an active 75-year-old medical practitioner. Successful outcome after ACL reconstruction can be achieved in selected older patients; chronological age is no barrier. PMID:24698585

Vaishya, Raju; Dhiman, Radhey Shyam; Vaish, Abhishek

2014-04-01

387

A 39-year-old man with dyspnoea, low forced expiratory volume and a large mass of the left hemithorax  

PubMed Central

In patients with intrathoracic neoplasms, low forced expiratory volume (FEV1) can preclude surgical treatment. Here, we present a case of a giant solitary fibroma of the pleura (SFTP) successfully treated by surgical removal in spite of low FEV1. A 39-year-old male patient was referred to our hospital with dyspnoea and chest distress. Computed tomography (CT) showed a large mass in the left chest. Spirometry showed FEV1 1.4 L (39% of the expected value). Computed tomography scan-guided transcutaneous aspiration biopsy was performed on the patient, and microscopic examination of the specimen revealed spindle tumor cells with a background of abundant collagen. Complete surgical resection was accomplished. The tumor was large and encapsulated. It measured 28 cm × 20 cm × 18 cm. The definitive diagnosis obtained by histopathology after resection was benign SFTP. The patient felt no dyspnoea at discharge. Surgical treatment of SFTP should be considered even in patients with a huge tumor and with increased post-operative risk.

Sun, Zhi-Gang; Liu, Xiang-Yan; Shan, Bao-Zhong; Zhang, Min; Li, Zhe

2013-01-01

388

Growth Disorders Among 6-Year-Old Iranian Children  

PubMed Central

Background: Sociodemographic factors are important determinants of weight disorders. National representative studies provide a view on this health problem at national and regional levels. Objectives: This study aimed to assess the distribution of growth disorders in terms of body mass index (BMI) and height in 6-year-old Iranian children using geographical information system (GIS). Materials and Methods: In this cross-sectional nationwide survey, all Iranian children entering public and private elementary schools were examined in a mandatory national screening program in 2009. Descriptive analysis was used to calculate the prevalence of underweight, overweight, obesity, and short stature. Then, ArcGIS software was used to draw the figures. Results: The study population consisted of 955388 children (48.5% girls and 76.5% urban). Overall, 20% of children were underweight, and 14.3% had high BMI, consisted of 10.9% overweight and 3.4% obese. The corresponding figure for short stature was 6.6%; however, these growth disorders were not equally distributed across various provinces. Conclusions: Our results confirmed unequal distribution of BMI and height of 6-year-old children in Iran generally and in most of its provinces particularly. The differences among provinces cannot be fully explained by the socioeconomic pattern. These findings necessitate a comprehensive national policy with provincial evidence-based programs.

Kelishadi, Roya; Amiri, Masoud; Motlagh, Mohammad Esmaeil; Taslimi, Mahnaz; Ardalan, Gelayol; Rouzbahani, Reza; Poursafa, Parinaz

2014-01-01

389

Chemical properties of two-year-old deciduous species  

SciTech Connect

Contents of ash, hot-water extractives, 1% sodium hydroxide extractives, alcohol-benzene extractive, lignin, holocellulose, alpha-cellulose, and pentosan were determined on two-year-old, short-rotation trees of autumn olive, black alder, black locust, eastern cottonwood, royal paulownia, silver maple, and sycamore. These plantations were established in 1978 on marginal agricultural land that was not suitable for food production in Illinois. Six comparable species of commercial lumber were also analyzed. Test results indicated that all chemical properties did vary with species, above-ground tree portions, and ages of species. The two-year-old juvenile trees had higher average extractives, holocellulose, pentosan, and ash content than did the lumber of matured wood. Black locust possessed the highest values of holocellulose and alpha-cellulose, while the eastern cottonwood had the highest extractive contents. Silver maple had the highest lignin content. Both bark and branches which consisted of about 32% of the mass weight of young trees, had a higher average lignin, extractive and ash content than those of the stemwood. Based on chemical composition, these seven juvenile deciduous species could serve as a raw material for the paper and chemical industries, as well as for energy. 19 references, 8 figures, 6 tables.

Chow, P.; Rolfe, G.L.; Lee, C.S.; White, T.A.

1983-01-01

390

Community Approaches to Serving Four-Year-Old Children in Wisconsin: Lessons Learned from Wisconsin Communities.  

ERIC Educational Resources Information Center

The Wisconsin Forces for Four-Year-Olds Project promotes a collaborative community approach to offering universal access to four-year-old kindergarten services for Wisconsin 4-year-olds. Presented in three major sections, this report offers an overview of a community approach to serving 4-year-olds, summarizes experiences in seven communities…

Rodgers-Rhyme, Anne; Wright, Arlene

391

Category-specific face prototypes are emerging, but not yet mature, in 5-year-old children.  

PubMed

Adults' expertise in face recognition has been attributed to norm-based coding. Moreover, adults possess separable norms for a variety of face categories (e.g., race, sex, age) that appear to enhance recognition by reducing redundancy in the information shared by faces and ensuring that only relevant dimensions are used to encode faces from a given category. Although 5-year-old children process own-race faces using norm-based coding, little is known about the organization and refinement of their face space. The current study investigated whether 5-year-olds rely on category-specific norms and whether experience facilitates the development of dissociable face prototypes. In Experiment 1, we examined whether Chinese 5-year-olds show race-contingent opposing aftereffects and the extent to which aftereffects transfer across face race among Caucasian and Chinese 5-year-olds. Both participant races showed partial transfer of aftereffects across face race; however, there was no evidence for race-contingent opposing aftereffects. To examine whether experience facilitates the development of category-specific prototypes, we investigated whether race-contingent aftereffects are present among Caucasian 5-year-olds with abundant exposure to Chinese faces (Experiment 2) and then tested separate groups of 5-year-olds with two other categories with which they have considerable experience: sex (male/female faces) and age (adult/child faces) (Experiment 3). Across all three categories, 5-year-olds showed no category-contingent opposing aftereffects. These results demonstrate that 5years of age is a stage characterized by minimal separation in the norms and associated coding dimensions used for faces from different categories and suggest that refinement of the mechanisms that underlie expert face processing occurs throughout childhood. PMID:24937629

Short, Lindsey A; Lee, Kang; Fu, Genyue; Mondloch, Catherine J

2014-10-01

392

NASA Administrator Dan Goldin greets 100-year-old VIP.  

NASA Technical Reports Server (NTRS)

Astronaut Andy Thomas (left) greets 100-year-old Captain Ralph Charles, one of the VIPs attending the launch of STS-99. Charles also met NASA Administrator Dan Goldin. An aviator who has the distinction of being the oldest licensed pilot in the United States, Charles is still flying. He has experienced nearly a century of flight history, from the Wright Brothers to the Space Program. He took flying lessons from one of the first fliers trained by Orville Wright, first repaired then built airplanes, went barnstorming, operated a charter service in the Caribbean, and worked as a test pilot for the Curtiss Wright Airplane Co. Charles watches all the Shuttle launches from his home in Ohio and his greatest wish is to be able to watch one in person from KSC.

2000-01-01

393

Acute scoliosis in a 3-year-old boy  

PubMed Central

The case describes the presentation of a fit and well 3-year-old boy to the emergency department of a district general hospital after he developed an acute scoliosis overnight. There was no history of trauma, his observations were normal and he had non-specific symptoms of lethargy and reduced appetite, but no fevers or respiratory distress. Bloods showed raised inflammatory markers and he was referred to orthopaedics as a septic disc as there was some spinal tenderness. An urgent MRI was considered initially but on further examination there was some reduced air entry on the left lung base which a chest radiograph confirmed as a left-sided pneumonia. A diagnosis of pneumonia and secondary functional scoliosis was made. The child was admitted under paediatrics and made a full recovery on antibiotics. At 8 weeks follow-up there was resolution of scoliosis clinically and radiologically.

Malhotra, Rishi; Murali-Ganesh, Raghav; Dunkley, Colin; Desai, Vikram

2012-01-01

394

Ectopic cilia in a 14-year-old boy.  

PubMed

Ectopic cilia is a very rare condition in human beings, usually presented as a tuft of densely grouped hair on the lateral quadrant of the upper eyelid or conjunctival surface of the eyelid. The embryologic origin of this anomaly is unknown, and few cases have been recorded in literature. In most cases, it causes no apparent medical morbidity but is treated by surgical excision because of its cosmetic aspect. We report a 14-year-old boy with ectopic cilia with approximately 20 hairs occurring as single and grouped hairs pattern emerging from anterior surface of eyelid. Positive history of the same anomaly in his paternal grandfather demonstrates evidence of an inherited genetic disorder. PMID:21276055

Baghestani, Shahram; Banihashemi, Seyyed Ali

2011-01-01

395

Prevalence studies of problematic behaviors in four-year-olds.  

PubMed

Prevalence rates for specific behaviors in the Problem Behavior Questionnaire (PBQ; Behar & Stringfield, 1974) and for four psychosomatically related behaviors (soiling, day and night wetting, and complaints about bodily aches) were estimated in a sample of 377 Swedish 4-year-olds described by their parents (mainly mothers). The results showed that several of the behaviors classified as outgoing conduct problems were common in this age group; boys showed more problematic behaviors than girls, as did children with older siblings. Firstborn children with younger siblings were more fearful and worried. No systematic differences between children in different types of day care were found. Maternal education had no relationship to reported child behaviors. The findings were discussed in terms of the four-year-age period as a period of transition and with regard to different family situations. PMID:1287827

Hagekull, B; Bohlin, G

1992-12-01

396

Xerostomia and medications among 32-year-olds  

PubMed Central

Objective To describe the prevalence and associations of xerostomia among adults in their early thirties, with particular attention to medication exposure as a putative risk factor. Material and Methods The prevalence and associations of xerostomia were investigated among 32-year-old participants in a long-standing prospective cohort study. Some 950 individuals were assessed at ages 26 and 32 years, with medications being recorded on both occasions. Results The prevalence of xerostomia was 10.0% (with no apparent gender difference), and was significantly higher among those taking antidepressants (odds ratio =4.7), iron supplements (OR =4.1) or narcotic analgesics (OR =2.4). Those taking antidepressants at both ages 26 and 32 years had 22 times the odds of reporting xerostomia. Conclusion Xerostomia may be a problem for a sizeable minority of young adults.

THOMSON, WILLIAM MURRAY; POULTON, RICHIE; BROADBENT, JONATHAN MARK; AL-KUBAISY, SHAIMA

2008-01-01

397

Septic Bursitis in an 8-Year-Old Boy  

PubMed Central

Background. The prepatellar bursa can become inflamed owing to repeated trauma. Prepatellar bursitis is extremely rare in children. Methods. We report the case of an 8-year-old boy who was treated for an erythematous, swollen, and severely painful right knee, fever, inability to bear weight on the leg, and purulent material draining from a puncture wound. We describe the differential diagnosis for tender swollen knee, including infection, gout, rheumatoid arthritis, and osteoarthritis. If untreated, prepatellar bursitis can progress to patellar osteomyelitis. Results. Wound cultures grew Streptococcus pyogenes, with the infection resolving with amoxicillin. Conclusions. A high index of suspicion is necessary in children presenting with prepatellar bursitis to prevent potentially devastating sequelae of infection of the septic joint.

Marconi, Dante; Plakas, Christos; Fisher, Margaret

2014-01-01

398

NASA Administrator Dan Goldin greets 10-year-old VIP.  

NASA Technical Reports Server (NTRS)

NASA Administrator Dan Goldin (center) talks to 10-year-old Jonathan Pierce (right), who is garbed in a protective cooling suit designed by NASA. In the background, between them, are Jonathan's mother, Penny; his grandfather, John Janocka; and his sister, Jaimie. At left is Mrs. Goldin. Jonathan suffers from erythropoietic protoporphyria, a rare condition that makes his body unable to withstand ultraviolet rays. The suit allows him to be outside during the day, which would otherwise be impossible. Jonathan's trip was funded by the Make-A-Wish Foundation and included a visit to Disney World. He and his family were among a dozen VIPs at KSC to view the launch of STS-99.

2000-01-01

399

NASA Administrator Dan Goldin greets 10-year-old VIP.  

NASA Technical Reports Server (NTRS)

NASA Administrator Dan Goldin (center) greets 10-year-old Jonathan Pierce (right), who is garbed in a protective cooling suit designed by NASA. In the background, between them, are Jonathan's mother, Penny; his grandfather, John Janocka; and his sister, Jaimie.. At left is Mrs. Goldin. Jonathan suffers from erythropoietic protoporphyria, a rare condition that makes his body unable to withstand ultraviolet rays. The suit allows him to be outside during the day, which would otherwise be impossible. Jonathan's trip was funded by the Make-A-Wish Foundation and included a visit to Disney World. He and his family were among a dozen VIPs at KSC to view the launch of STS-99.

2000-01-01

400

NASA Administrator Dan Goldin greets 10-year-old VIP.  

NASA Technical Reports Server (NTRS)

NASA Administrator Dan Goldin (center) presents a bag of special gifts to 10-year-old Jonathan Pierce (right), who is garbed in a protective cooling suit designed by NASA. In the background, between them, are Jonathan's mother, Penny; his grandfather, John Janocka; and his sister, Jaimie.. At left is Mrs. Goldin. Jonathan suffers from erythropoietic protoporphyria, a rare condition that makes his body unable to withstand ultraviolet rays. The suit allows him to be outside during the day, which would otherwise be impossible. Jonathan's trip was funded by the Make-A-Wish Foundation and included a visit to Disney World. He and his family were among a dozen VIPs at KSC to view the launch of STS-99.

2000-01-01

401

Lymph node metastasis in gastric cardiac adenocarcinoma in male patients  

PubMed Central

AIM: To reveal the clinicopathological features and risk factors for lymph node metastases in gastric cardiac adenocarcinoma of male patients. METHODS: We retrospective reviewed a total of 146 male and female patients with gastric cardiac adenocarcinoma who had undergone curative gastrectomy with lymphadenectomy in the Department of Surgery, Xin Hua Hospital and Rui Jin Hospital of Shanghai Jiaotong University Medical School between November 2001 and May 2012. Both the surgical procedure and extent of lymph node dissection were based on the recommendations of Japanese gastric cancer treatment guidelines. Univariate and multivariate analyses of lymph node metastases and the clinicopathological features were undertaken. RESULTS: The rate of lymph node metastases in male patients with gastric cardiac adenocarcinoma was 72.1%. Univariate analysis showed an obvious correlation between lymph node metastases and tumor size, gross appearance, differentiation, pathological tumor depth, and lymphatic invasion in male patients. Multivariate logistic regression analysis revealed that tumor differentiation and pathological tumor depth were the independent risk factors for lymph node metastases in male patients. There was an obvious relationship between lymph node metastases and tumor size, gross appearance, differentiation, pathological tumor depth, lymphatic invasion at pN1 and pN2, and nerve invasion at pN3 in male patients. There were no significant differences in clinicopathological features or lymph node metastases between female and male patients. CONCLUSION: Tumor differentiation and tumor depth were risk factors for lymph node metastases in male patients with gastric cardiac adenocarcinoma and should be considered when choosing surgery.

Ren, Gang; Chen, Ying-Wei; Cai, Rong; Zhang, Wen-Jie; Wu, Xiang-Ru; Jin, Ye-Ning

2013-01-01

402

Traumatic brain injury in infants and toddlers, 0-3 years old  

PubMed Central

Object: Children 0–3 years old present a completely different neurotraumatic pathology. The growing and the development processes in this age group imply specific anatomical and pathophysiological features of the skull, subarachnoid space, CSF flow, and brain. Most common specific neurotraumatic entities in children 0–3 years old are cephalhematoma, subaponeurotic (subgaleal) hematoma, diastatic skull fracture, grow skull fracture, depressed (‘ping–pong’) skull fracture, and extradural hematoma. Methods: We present our 10 years experience in neuropediatric traumatic brain injuries, between 1999 and 2009, in the First Department of Neurosurgery and Pediatric Intensive Care Unit. Including criteria were children, 0–3 years old, presenting only traumatic brain injury. We excluded patients with politrauma, who require a different management. Results: We present the incidence of these specific head injuries, clinical and imagistic features, treatment, and outcome. We found 72 children with diastatic skull fracture, 61 cases with depressed (‘ping–pong’) skull fracture, 22 cases with grow skull fracture, 11 children harboring intrusive skull fracture, 58 cephalhematomas, 26 extradural hematomas, and 7 children with severe brain injury and major posttraumatic diffuse ischemia (‘black–brain’). Usually, infants and toddlers present with seizures, pallor, and rapid loss of consciousness. First choice examination, in all children was cerebral CT–scan, and for follow–up, we performed cerebral MRI. We emphasize on the importance of seizure prevention in this age group. Children presenting with extensive diffuse ischemia (‘black–brain’) had a poor outcome, death occurring in all 7 cases. Conclusion: Children 0–3 years old, present with a total distinctive pathology than adults. Children with head injury must be addressed to a pediatric department of neurosurgery and pediatric intensive care unit. Prophylaxis pays the most important role in improving the outcome.

Gorgan, MR; Tascu, A; Sandu, AM; Rizea, RE

2011-01-01

403

An 85-year-old case with Hashimoto's encephalopathy, showing spontaneous complete remission.  

PubMed

We report an 85-year-old man with Hashimoto's encephalopathy (HE) who showed spontaneous complete remission. The autoantibody against the amino (NH2) terminal region of alpha-enolase was positive in our patient. Neuropsychological manifestations, such as personality change and progressive cognitive impairment, gradually improved over approximately 6 weeks after onset of disease without corticosteroid treatment in parallel with a decrease in the anti-thyroglobulin antibody in the cerebrospinal fluid. HE should be considered as a possible diagnosis even in elderly patients with neuropsychiatric symptoms, particularly when a previous history of thyroid disease is present. PMID:17878654

Katoh, Nagaaki; Yoshida, Takuhiro; Shimojima, Yasuhiro; Gono, Takahisa; Matsuda, Masayuki; Yoneda, Makoto; Ikeda, Shu-ichi

2007-01-01

404

Alopecia associated with strontium ranelate use in a 62-year-old woman.  

PubMed

Strontium ranelate is an effective drug that was developed for treating osteoporosis. Here, we report the case of a 62-year-old woman who developed headache and diffuse scalp hair loss 1 week after receiving strontium ranelate treatment for osteoporosis. The treatment was subsequently stopped because of the intractable headache. Nevertheless, the patient continued to lose hair for 6 weeks following treatment discontinuation. Histopathological analysis of scalp tissues revealed anagen effluvium. The patient's hair started regrowing slowly 2 months after treatment with strontium ranelate was discontinued. PMID:22525979

Lee, Y-Y; Yang, C-H; Chen, C-H; Hwang, J-S

2013-03-01

405

A 25-year-old man with 50 teeth: Astonishing but true!!  

PubMed

Retained primary teeth is a well-known process but multiple retained primary, permanent, and supernumerary teeth that too in an asymptomatic, non-syndromic patient is a rare possibility that has rarely been reported in literature. This case report discusses the clinical and radiographic details along with treatment options in a 21-year-old patient having a total number of 50 teeth, i.e., 16 retained primary teeth, 32 permanent teeth, and 2 supernumerary teeth without being associated with any known syndrome complex or metabolic disorder. PMID:24082755

Bhatia, Vishwas; Jain, Nitul; Bhatia, Garima; Garg, Rakesh

2013-07-01

406

A 25-year-old man with 50 teeth: Astonishing but true!!  

PubMed Central

Retained primary teeth is a well-known process but multiple retained primary, permanent, and supernumerary teeth that too in an asymptomatic, non-syndromic patient is a rare possibility that has rarely been reported in literature. This case report discusses the clinical and radiographic details along with treatment options in a 21-year-old patient having a total number of 50 teeth, i.e., 16 retained primary teeth, 32 permanent teeth, and 2 supernumerary teeth without being associated with any known syndrome complex or metabolic disorder.

Bhatia, Vishwas; Jain, Nitul; Bhatia, Garima; Garg, Rakesh

2013-01-01

407

Pathology Case Study: An 80-Year-Old Female with a Neck Mass  

NSDL National Science Digital Library

This is an ear nose & throat case study presented by the University of Pittsburgh Department of Pathology in which an 80-year-old female has insular carcinoma of the thyroid (i.e. a neck mass). Visitors are given both the microscopic and gross descriptions, including images, and are given the opportunity to diagnose the patient. This is an excellent resource for students in the health sciences to familiarize themselves with using patient history and laboratory results to diagnose. It is also a helpful site for educators to use to introduce or test student learning in ear, nose, and throat medicine.

Schubert, Eric

2007-12-20

408

Pathology Case Study: A 54-Year-Old Man with a Right Cheek Mass  

NSDL National Science Digital Library

This is a case study presented by the University of Pittsburgh Department of Pathology in which a 54-year-old man has a recurrent neoplasm in his right cheek. Visitors are given both the microscopic and gross descriptions, including images, and are given the opportunity to diagnose the patient. This is an excellent resource for students in the health sciences to familiarize themselves with using patient history and laboratory results to diagnose disease. It is also a helpful site for educators to use to introduce or test student learning in head and neck pathology

Nine, Jeff S.; Schubert, Eric

2007-07-29

409

23-year-old female with dyspnea, hematuria, and seizure progressing to respiratory failure.  

PubMed

Takayasu arteritis is a rare chronic inflammatory disease on unknown etiology. We report a 23-year old female who presented with fever, shortness of breath and abdominal pain. Shortly thereafter the patient developed hematuria, hemoptysis and seizure progressing to respiratory failure. She was found to have aortitis and alveolar hemorrhage. We discuss the clinical manifestations and the diagnostic work up of Takayasu arteritis. The patient's response to therapy and a discussion on treatment modalities of the disease are also included in the report. PMID:24003540

Yaqoob, M; El-Sameed, Y A

2013-03-01

410

Gender identity disorder and autism spectrum disorder in a 23-year-old female.  

PubMed

We describe the case of a 23-year-old woman with Gender Identity Disorder (GID) asking for a cross-sex hormonal treatment with sex reassignment surgery and who was recently diagnosed with Autism Spectrum Disorder (ASD). Gender identity clinics are now reporting an overrepresentation of individuals with ASD among GID patients. The prevalence of ASD is 10-fold higher among GID patients than in general population. However, few case reports or studies have explored the co-occurrence of ASD and GID. This co-occurrence is relevant for diagnostic and clinical management and also raises important theoretical issues. PMID:23835847

Lemaire, Mathieu; Thomazeau, Barbara; Bonnet-Brilhault, Frédérique

2014-02-01

411

Management of a bilobed testicle in a 12-year-old boy  

PubMed Central

A bilobed testicle is an extremely rare congenital malformation, with only five cases published to date. We present the case of a 12-year-old boy with a bilobed testicle. With so few cases available, much of what is known about the management of this condition is based on cases of polyorchidism and the complications associated with this, including malignancy and torsion. Whilst surgery may play a role in some patients, uncomplicated cases can be managed conservatively. There is no long-term data on the outcome of conservative management but we propose this patient can be discharged if no further changes are identified after 18 months.

Halliday, Laura J.

2013-01-01

412

Pathology Case Study: A 73-Year-Old Jewish Female with Anemia of Unknown Etiology  

NSDL National Science Digital Library

This is a case study presented by the University of Pittsburgh Department of Pathology in which a 73-year-old Jewish woman has anemia of unknown etiology and a low reticulocyte count. Visitors are given the microscopic description, including images, and are given the opportunity to diagnose the patient. This is an excellent resource for students in the health sciences to familiarize themselves with using patient history and laboratory results to diagnose disease. It is also a helpful site for educators to use to introduce or test student learning in hematopathology.

Goldblatt, Curtis

2007-12-28

413

Pathology Case Sstudy: A 59-Year-Old Female with a Right Atrial Mass  

NSDL National Science Digital Library

This is a cardiovascular pathology case study presented by the University of Pittsburgh Department of Pathology in which a 59-year-old black female has diffuse large cell lymphoma (i.e. right atrial mass). Visitors are given both the microscopic and gross descriptions, including images, and are given the opportunity to diagnose the patient. This is an excellent resource for students in the health sciences to familiarize themselves with using patient history and laboratory results to diagnose. It is also a helpful site for educators to use to introduce or test student learning in cardiovascular pathology.

Schubert, Eric

2007-12-14

414

Multiple Presacral Teratomas in an 18-year-old Girl: A Case Report  

PubMed Central

Although the sacrococcygeal area is the most common site for a teratoma in infants, it is a rare site for a teratoma in older patients. Most of the teratomas found in this area in adults are single mass, but in a few cases, multiple masses have been reported. The author reports on the case of an 18-year-old female patient with 3 presacral teratomas. The tumors were surgically removed via a transabdominal approach and were pathologically diagnosed as mature cystic teratomas. This case report indicates that an adult presacral teratoma can appear as multiple tumors, although it is very unusual.

2011-01-01

415

Rabies in a nine-year-old child: The myth of the bite  

PubMed Central

A nine-year-old boy died from rabies encephalitis caused by a rabies virus variant associated with insectivorous bats. The patient was most likely infected in the Laurentian Mountains of western Quebec, but neither the patient nor his parents remembered any direct contact with an animal. The diagnosis was made seven days after the start of symptoms. After examining the most recent cases of rabies in North America, it is obvious that rabies following bat exposure can occur without history of a documented bite. The present case report emphasizes that the general public and medical care providers need better information about the risks associated with exposure to bats.

Despond, Olivier; Tucci, Marisa; Decaluwe, Helene; Gregoire, Marie-Claude; S Teitelbaum, Jeanne; Turgeon, Nathalie

2002-01-01

416

A previously healthy 15-year-old girl with high fever and progressive dyspnoea.  

PubMed

A 15-year-old girl was admitted with a high fever and progressive malaise, vomiting, anorexia and abdominal complaints. She previously had a sore throat and unilateral painful swollen lymph nodes in the neck. Laboratory investigation indicated a bacterial infection. Blood cultures were taken. There was infiltrate in the left lung. Pneumonia complicated with sepsis was suspected and ceftriaxone was started. The patient's condition deteriorated. Computed tomography (CT) scan showed progressive infiltrates in both lungs and pleural effusion. Blood culture led to the diagnosis. After changing antibiotics the patient slowly improved. Antibiotics were continued for several weeks. PMID:18253750

van Delft, Eveline; Vandewall, Maartje; Curiel, Franklin B; Rutten, Matthieu J C M; Schneeberger, Peter M

2008-06-01

417

Pathology Case Study: A 33-Year-Old Man with a Testicular Lesion  

NSDL National Science Digital Library

This is a case study presented by the University of Pittsburgh Department of Pathology in which a 33-year-old morbidly obese man has a testicular lesion. Visitors are given both the microscopic and gross descriptions, including images, and are given the opportunity to diagnose the patient. This is an excellent resource for students in the health sciences to familiarize themselves with using patient history and laboratory results to diagnose disease. It is also a helpful site for educators to use to introduce or test student learning in genitourinary pathology.

Horn, Kevin D.

2007-12-31

418

Pathology Case Study: Bladder Mass in a 57-Year-Old Woman  

NSDL National Science Digital Library

This is a case study presented by the University of Pittsburgh Department of Pathology in which a 57-year-old woman has a history of bladder tumors. Visitors are given both the microscopic and gross descriptions, including images, and are given the opportunity to diagnose the patient. This is an excellent resource for students in the health sciences to familiarize themselves with using patient history and laboratory results to diagnose disease. It is also a helpful site for educators to use to introduce or test student learning in genitourinary pathology.

Hakam, Ardeshir

2007-08-05

419

Pathology Case Study: Right Cerebellopontine Angle Mass in a 64-Year-Old Woman  

NSDL National Science Digital Library

This is a case study presented by the University of Pittsburgh Department of Pathology in which a 64-year-old woman is complaining of dizziness and hearing loss. Visitors are given both the microscopic and gross descriptions, including images, and are given the opportunity to diagnose the patient. This is an excellent resource for students in the health sciences to familiarize themselves with using patient history and laboratory results to diagnose disease. It is also a helpful site for educators to use to introduce or test student learning in neuropathology.

Nine, Jeff S.

2007-08-04

420

Primary uveal melanoma in a 4-year-old black child.  

PubMed

Primary uveal melanoma is extremely rare in children and also among blacks. Uveal melanomas may be associated with various preexisting conditions, including congenital ocular melanocytosis and dysplastic nevus syndrome. We report the case of a 4-year-old black girl who presented with pronounced proptosis and no light perception secondary to a massive intraocular tumor with extrascleral extension. Biopsy of the tumor confirmed the diagnosis of primary uveal melanoma, and the patient was treated by enucleation and external beam radiation therapy. Although metastatic disease was ruled out at the time, the patient died approximately 3 months later. PMID:24160981

Gray, Michael E; Shaikh, Adeel H; Corrêa, Zélia M; Augsburger, James J

2013-10-01

421

Unicameral bone cyst of the proximal tibia in a five year old girl  

PubMed Central

Unicameral bone cysts (UBCs) are benign, osteolytic lesions which are often asymptomatic and are commonly seen in the proximal of humerus and femur. The average age at diagnosis is 9-11 years and there is a male preponderance with a male-to-female ratio of approximately 2-2.5 to 1. We describe a case of 5-year-old girl who presented to orthopedic clinic with a 4-month history of painful limping. Plain radiography of the right knee demonstrated a well-defined lytic lesion in the proximal of the tibia. Open biopsy and then curettage and bone grafting with bone- substitute was performed. The diagnosis of this condition requires a high index of suspicion. This report demonstrates that all UBCs do not have the same clinical patterns and with adequate attention good results can be achieved.

Tahririan, Mohammadali; Motiffard, Mehdi

2012-01-01

422

Aldosterone-secreting adrenal cortical adenoma in an 11-year-old child and collective review of the literature  

Microsoft Academic Search

We report a rare case of primary hyperaldosteronism due to a unilateral adrenal cortical adenoma in an 11-year-old female patient. The patient presented with hypertension, hypokalaemia and metabolic alkalosis, associated with inappropriate kaliuresis. The diagnosis was supported by the following laboratory findings: elevated plasma aldosterone, suppressed plasma renin activity, nonsuppressible aldosterone secretion following saline infusion and absent plasma aldosterone reponse

Ju-Tzu Li; San-Ging Shu; Ching-Shiang Chi

1994-01-01

423

Management and Sequelae of a 41-Year-Old Jehovah's Witness With Severe Anhydrous Ammonia Inhalation Injury.  

PubMed

Anhydrous ammonia is a commonly used chemicals that are found in fertilizer, refrigeration, and in other occupational environments. Lung damage because of inhalation of ammonia can be devastating, producing debilitating lung disease and can ultimately lead to death. This is the case of a 41-year-old male, previously healthy, Jehovah's Witness, who was working at a poultry plant facility when an explosion occurred exposing him to toxic levels of anhydrous ammonia. Our patient developed end-stage lung disease after sustaining a severe ammonia inhalation injury. Despite aggressive pulmonary rehabilitation, the patient continued to deteriorate, and his only option for a chance at improved quality of life was a double-lung transplant. To our knowledge, this is the first report of a bloodless lung transplantation for inhalational lung injury in the literature. Further study is needed to better understand the effects of ammonia on lung physiology in order to better manage and treat patients who develop acute and chronic lung complications after exposure. PMID:24784905

Ortiz-Pujols, Shiara; Jones, Samuel W; Short, Kathy A; Morrell, Matthew R; Bermudez, Christian A; Tilley, Stephen L; Cairns, Bruce A

2014-01-01

424

Male Breast Adenoid Cystic Carcinoma  

PubMed Central

Introduction Adenoid cystic carcinoma (ACC) of the breast is a rare condition, and cases in male patients are even less common. Case We describe a case of ACC of the breast with axillary lymph node metastasis, disseminated osteolytic bone metastasis and bone marrow involvement in a 41-year-old man. Conclusion Male breast ACC is an extremely rare malignancy; there can be difficulty in obtaining a final diagnosis. We report this case because of its rarity.

Yoo, Seung Jin; Lee, Dong Seok; Oh, Ho Suk; Kim, Hyun Joong; Kim, Moon Ho; Ahn, Youg Chel; Kang, Gil Hyun; Eom, Dae-Woon; Cha, Choong Hwan; Ahn, Heui June

2013-01-01

425

The steroids of 2000-year-old human coprolites.  

PubMed

Six samples of human coprolites, some more than 2,000 years old, were analyzed for fecal steroid composition. Despite this very lengthy period of storage, the fecal steroids of coprolites were remarkably similar to those of stool samples collected today. The sterol nucleus was clearly rather stable under the dry environmental conditions of the Nevada Caves. The steroid content (microgram/g dried weight) of coprolite was low in comparison to that of modern man. The bile acid/cholesterol and plant sterol/cholesterol ratios of the coprolite, however, were similar to these ratios of the stools of modern man. In the six coprolites, an average 73% of the neutral steroids was digitonin-precipitable. This precipitate was composed of cholesterol and three plant sterols (campesterol, stigmasterol, and beta-sitosterol) and their bacteria-modified products. A portion of the neutral steroids had been converted to products tentatively identified as epimers of these steroids. Individual bile acids were identified in the coprolite. The bile acid composition of the coprolite was similar to that of the stool of modern man. PMID:344825

Lin, D S; Connor, W E; Napton, L K; Heizer, R F

1978-02-01

426

Emotion displays in two-year-olds during mishaps.  

PubMed

Although it has been shown that toddlers express distress when personal or physical events violate their expectations, there has been little detailed examination of their emotional reactions to such events. In this study, 45 2-year-olds were observed during 2 mishaps: a doll breaking and juice spilling. Their emotional reactions and their attempts to fix the mishap were coded. 2 components to their reactions to mishaps were found: one of tension and frustration, and another of concerned reparation. Mishaps elicited more negative emotions in toddlers than free play, and most toddlers attempted to correct the mishap. Children's styles of emotional response to mishaps may be related to maternal mental health. Symptoms of depression and anxiety in mothers were related to a suppression of tension and frustration in their offspring. Maternal acting out symptoms were not related to toddlers' reactions to mishaps. The findings are discussed in terms of the role of emotion in the formation of individual differences in sociomoral functioning and factors contributing to early differences. PMID:1611936

Cole, P M; Barrett, K C; Zahn-Waxler, C

1992-04-01

427

An 8-year-old boy with hypereosinophilic syndrome.  

PubMed

Hypereosinophilic syndrome (HES) is a heterogeneous group of uncommon disorders characterized by the presence of marked peripheral blood eosinophilia and tissue eosinophilia, resulting in a wide variety of clinical manifestations. We present the case of an 8-year-old boy with HES. He complained of recurrent abdominal pain, general fatigue, and diarrhea. Laboratory data showed marked eosinophilia, elevated total IgE with positive specific IgE antibodies to common inhalant and food allergens, and elevated serum CCL17/TARC. A chest CT scan revealed central bronchiectasis, bronchial wall thickening, a mosaic attenuation pattern, and multiple small nodules in lung parenchyma; abdominal CT showed a thickened bladder wall. Gastrointestinal endoscopy revealed scarring in the gastric mucosa and mucosal erosion in the duodenum. Immunohistochemical examination demonstrated numerous eosinophil infiltrations with extensive extracellular eosinophil major basic protein deposition in the gastric mucosa. Only high-dose oral steroid was effective and cyclosporine appeared to have a steroid-sparing effect. HES is extraordinary rare in children and the long-term prognosis in pediatric HES is not well known. Comprehensive diagnostic procedures are vital for the early detection and management of complications in pediatric HES. PMID:21646806

Hosoki, Koa; Nagao, Mizuho; Iguchi, Kosei; Ihara, Toshiaki; Yamada, Yoshiyuki; Higashigawa, Masamune; Kephart, Gail M; Kita, Hirohito; Fujisawa, Takao

2011-01-01

428

Propinquity, sociability and excitement: exploring the normalisation of sensible drug use among 15–16-year-olds in north-west England and north-east Wales  

Microsoft Academic Search

This paper explores normalised drug use as an aspect of young people's leisure careers. Qualitative data generated by 24 single-sex focus groups with 153 (85 males; 68 females) 15–16-year-olds attending seven schools in north-west England and north-east Wales revealed that young people's drug use tended to be both heterogeneous and situation specific. Indeed, rather than being actively sought out, 15–16-year-olds

Andy Smith; Miranda Thurston; Ken Green

2011-01-01

429

Diaphragmatic hernia in an 8-year-old with Ehlers-Danlos syndrome.  

PubMed

Ehlers-Danlos syndrome (EDS) includes a group of connective-tissue disorders characterized by abnormal collagen metabolism. The diverse spectrum of this disease and its complications present a distinct challenge to the surgeon. Patients with this hereditary disorder may have hyperelastic or fragile skin, poor wound healing, hypermobile joints, clotting abnormalities, spontaneous pneumothoraces, recurrent hernias, bowel perforation, and vascular complications. An 8-year-old female with EDS type VII and a newly diagnosed diaphragmatic hernia is presented. Surgical considerations of this syndrome are reviewed. PMID:9799373

Iglesias, J L; Renard, T

1998-10-01

430

A rare case of carcinoma cuniculatum of the penis in a 55-year-old.  

PubMed

Carcinoma cuniculatum of the penis is an extremely rare variant of squamous cell carcinoma characterized by an endophytic deeply branching and burrowing growth pattern. One documented case series demonstrated afflicted patients ranging in age from 73-83 years with the tumour located on the glans penis, coronal sulcus or foreskin. We report a case of a 55-year-old with disease located on the ventral aspect of the shaft of the penis. The tumour was invasive into the deep dermal connective tissue, comparatively superficial to all previous documented cases. He subsequently underwent a partial penectomy. The case is discussed with a brief review of the literature. PMID:20944791

Lau, Paul; Li Chang, Hector H; Gomez, Jose A; Erdeljan, Petar; Srigley, John R; Izawa, Jonathan I

2010-10-01

431

Orbital Extension of a Giant Ethmoidal Sinus Osteoma in a 30-Year-old Female  

PubMed Central

Introduction: Osteoma is a benign tumor rarely found in the paranasal sinuses. Case Report: A 30-year-old female presented with an 8-month history of proptosis of the right eye that was progressing slowly. She was diagnosed with ethmoid osteoma and managed with collaborative surgery at the ophthalmology and otolaryngology departments. After surgery, the patient suffered visual loss that was managed medically. The surgical steps and protocol used for safe removal are discussed in the report. Conclusion: Management of a giaint osteoma extending to orbital tissue needs meticulous dissection through open approach and collaborative surgery by otolaryngologist and ophthalmologist.

Karbassi, Esmat; Arabi Mianroodi, Aliasghar; Shamsadini, Ayeh

2013-01-01

432

Vesical varices causing gross hematuria in a four-year-old girl.  

PubMed

Primary vesical varices are rare. We report a case of a 4-year-old girl who presented with recurrent gross hematuria secondary to primary vesical varices. Ultrasonography, enhanced computed tomography, and voiding cystourethrogram revealed a solid mass in the right wall of the bladder. Cystoscopy revealed a group of dilated submucosal veins and a red mass. The mass was ablated, and the histopathologic examination demonstrated varices of the bladder. Observation of the patient for 6 months postoperatively showed no recurrence of the hematuria. PMID:22119255

Hou, Ying; Xue, YanSheng; Yang, Yi; Sun, Rong Guo

2012-04-01

433

Isolated intramedullary spinal cysticercosis in a 10-year-old female showing dramatic response with albendazole  

PubMed Central

Neurocysticercosis is the most common parasitic infection of the central nervous system caused by larvae of Taenia solium. Spinal cysticercosis is an uncommon site of cysticercal infection, and isolated intramedullary involvement is even rarer. We present a case of 10-year-old girl who presented with gradual onset paraparesis with sensory loss and bowel and bladder incontinence. Magnetic resonance imaging (MRI) of spine revealed a cystic lesion with mural nodule (scolex) which was diagnostic for cysticercosis. Patient was treated with antihelminthic, which led to marked clinico-radiological improvement.

Azfar, Shah F.; Kirmani, Sanna; Badar, Farheen; Ahmad, Ibne

2011-01-01

434

Intraorbital epidermoid cyst: a 5-year-old with exophthalmos and strabismus.  

PubMed

A 5-year-old girl with right exophthalmos and esotropia presented to ophthalmology outpatient clinics. Orbital computed tomography revealed a 20- to 30-mm oval soft tissue mass lying superolateral to the right lateral rectus muscle in the orbit. The patient was operated on by a neurosurgical team, the csyt was removed totally, and examination of the pathologic specimen, which reveals the epidermoid cyst, was performed. After the operation, exophthalmos and esotropia were improved, and visual acuity was increased. Although itis seen as a rare entity in the orbit, epidermoid cyst must be considered during the investigation of exophthalmos. PMID:22446470

Ekinci, Bengu; Koktekir, Ender; Kal, Ali; Karalezli, Aylin; Erinanc, Hilal

2012-03-01

435

Incidental diagnosis of unilateral renal and adnexal agenesis in a 46-year-old multiparous woman  

PubMed Central

Patient: Female, 46 Final Diagnosis: Unilateral adneksial and renal agenesis Symptoms: Menometrorrhagia Medication: — Clinical Procedure: Total abdominal hysterectomy and unilateral salphingoopherectomy Specialty: Obstetrics and gynecology Objective: Rare disease Background: Unilateral renal and adnexal agenesis is quite rare. Absence of any uterine abnormality accompanying current urogenital abnormalities is even rarer. Case Report: We report on the case of a 46-year-old multiparous woman, incidentally diagnosed to have unilateral renal, ovarian, and tubal agenesis just before hysterectomy due to menometrorrhagia and myoma uteri. Conclusions: Any diagnosis of a urogenital abnormality necessitates investigation of comorbid renal or genital abnormalities.

Gursoy, Asl? Yarc?; Akdemir, Nermin; Hamurcu, Ugur; Gozukucuk, Murat

2013-01-01

436

38-year-old woman with recurrent abdominal pain, but no fever  

PubMed Central

A 38-year-old woman presented with 2 days history of left-flank pain. She had similar episodes of abdominal pain as well as chest pain several times, but symptoms disappeared spontaneously. Each time she developed pain, there was no fever. After ruling out common causes of recurrent abdominal pain, familial Mediterranean fever (FMF) was considered as a potential diagnosis. Genetic tests revealed multiple heterozygote mutations, which may be associated with FMF. Patients with Mediterranean fever mutations may present with atypical presentations without fever, like in this case. Astute clinical suspicion is required to make an accurate diagnosis.

Iwata, Kentaro; Toma, Tomoko; Yachie, Akihiro

2012-01-01

437

Pathology Case Study: Brainstem Mass in a 2-Year-Old Female  

NSDL National Science Digital Library

The Department of Pathology at the University of Pittsburgh School of Medicine maintains a website with hundreds of case studies and sample diagnoses. These case studies are great learning tools for those studying medicine and planning on entering a medical field. This specific case involves the diagnosis of a 2-year-old female patient suffering from neck pain. A gross description of an MRI scan, and microscopic images are provided. Using the information provided, students are encouraged to make their own diagnosis and then check it against the official findings in the "Final Diagnosis" section.

Nine, Jeff S.

2007-08-09

438

Ocular myasthenia gravis and Graves disease in a 10-year-old child.  

PubMed

We report the association between myasthenia gravis and Graves disease in a 10-year-old boy and discuss the important aspects of both diseases, the importance of recognizing the association, and the investigations of choice to distinguish the 2 disorders. Early diagnosis of the 2 disorders may help in effective treatment institution with more rapid treatment responses with a possible improvement in prognosis and clinical course. Resolution of myasthenia gravis is not expected until the euthyroid state is restored. We recommend complete thyroid status review on all patients presenting with ocular myasthenia gravis. PMID:19406759

Koves, Ildiko H; Cameron, Fergus J; Kornberg, Andrew J

2009-05-01

439

Isolated Spontaneous Celiac Artery Dissection in a 47-Year-Old Man with von Willebrand Disease  

PubMed Central

Isolated spontaneous dissection of the celiac artery is rare, and its occurrence without aortic dissection is even rarer. The typical symptom of this dissection is acute-onset abdominal pain. Complications of the condition include aneurysm formation, rupture, and abdominal-organ ischemia or infarction, especially in the liver or spleen. We report the case of a 47-year-old man with von Willebrand disease who had an isolated spontaneous dissection of the celiac artery. We used computed tomography and computed tomographic angiography in the diagnosis and characterization of the dissection. To our knowledge, this is the first report of celiac artery dissection in a patient with von Willebrand disease.

Rehman, Aziz Ur; Nadella, Srikanth; Sohail, Umair

2014-01-01

440

Isolated spontaneous celiac artery dissection in a 47-year-old man with von Willebrand disease.  

PubMed

Isolated spontaneous dissection of the celiac artery is rare, and its occurrence without aortic dissection is even rarer. The typical symptom of this dissection is acute-onset abdominal pain. Complications of the condition include aneurysm formation, rupture, and abdominal-organ ischemia or infarction, especially in the liver or spleen. We report the case of a 47-year-old man with von Willebrand disease who had an isolated spontaneous dissection of the celiac artery. We used computed tomography and computed tomographic angiography in the diagnosis and characterization of the dissection. To our knowledge, this is the first report of celiac artery dissection in a patient with von Willebrand disease. PMID:24955061

Rehman, Aziz Ur; Almanfi, Abdelkader; Nadella, Srikanth; Sohail, Umair

2014-06-01

441

[Critical stenosis left main coronary artery in 39-year-old woman treated with percutaneous angioplasty].  

PubMed

Isolated critical stenosis of left main coronary artery (LMCA) due to atherosclerosis is very rare and affects about 0.2% of patients. We present the case of a 39-year-old, non-smoker women with risk factors for diseases of the cardiovascular system in the form of hypercholesterolaemia and hypertension, in addition to positive family history and chronic oral contraception. Sick from occurring since atypical angina masked depressive symptoms, with a critical stenosis of LMCA and little suggestive symptoms of ischaemia because of the existing collateral circulation. PMID:23907910

Roszczyk, Nikolina; Peruga, Jan Zbigniew; Wierzbowska-Drabik, Karina; Kasprzak, Jaros?aw Damian

2013-01-01

442

A rare cause of submandibular swelling in a 12-year-old child: pleomorphic adenoma.  

PubMed

Pleomorphic adenoma is rare in pediatric populations, where viral and congenital problems are the usual culprits responsible for submandibular masses. We report the case of a 12-year-old child who presented with a painless right submandibular mass that had developed over the course of 4 months. The patient denied fever, erythema, and edema. The mass was diagnosed as a branchial cleft cyst before complete excision was performed. The pattern and etiology of a pleomorphic adenoma in children differs from those in adults. In children, it requires prompt and correct diagnosis to keep morbidity and mortality at a minimum. PMID:24452892

Braich, Puneet S; Shetty, Shohan; Lingampally, Archana; Ajemian, Michael S; Bhaya, Mahesh H

2014-01-01

443

A Case of Juvenile Huntington Disease in a 6-Year-Old Boy  

PubMed Central

Huntington disease is a neurodegenerative disorder distinguished by the triad of dominant inheritance, choreoathetosis and dementia, usually with onset in the fourth and fifth decades. It is caused by an unstable cytosine-adenine-guanine (CAG) trinucleotide repeat expansion in the gene IT15 in locus 4p16.3. Juvenile HD that constitutes about 3% to 10% of all patients is clinically different from adult-onset form and characterized by a larger number of CAG repeats typically exceeding 60. We report a case of a 6-year-old boy with myoclonic seizure and 140 CAG repeats confirmed by molecular genetic analysis.

Sunwoo, Jun-Sang; Lee, Soon-Tae; Kim, Manho

2010-01-01

444

[Lymphomatoid papulosis in a 2 1/2-year-old boy].  

PubMed

Lymphomatoid papulosis (LyP) is a rare cutaneous lymphoproliferative disorder that has malignant histologic features and a benign clinical course. LyP is classified according to the WHO/EORTC classification for cutaneous lymphoma as a CD30-positive lymphoproliferative disorder. Few previous reports have detailed features of LyP in pediatric and adolescent patients, but LyP very rarely presents in early childhood. A 2 1/2-year-old boy presented with a 1-year history of recurrent papular and nodular lesions on the face and trunk. Clinical and histopathologic criteria lead to the diagnosis lymphomatoid papulosis. PMID:22037883

Amann, P M; Megahed, M

2011-11-01

445

The prevalence of gingivitis among 4-16 year old schoolchildren in Kaunas  

Microsoft Academic Search

SUMMARY The objective of this study is to investigate the incidence of gingivitis and periodontitis among schoolchildren of 6 - 14 years old in Kaunas City. The state of oral hygiene and incidence of periodontitis was evaluated among 89 school- children between 6-8 years old, 86 schoolchildren between 9-11 years old and 75 schoolchildren between 12-14 years old. After investigating

Jurate Pauraite; Simona Milciuviene; J. Sakalauskiene

2003-01-01

446

Veno-occlusive disease in a male patient with Marfan syndrome and common acute lymphoblastic leukemia during induction therapy.  

PubMed

Veno-occlusive disease (VOD) of the liver is characterized by jaundice, painful hepatomegaly, and retention of fluids. VOD is a severe complication in allogeneic stem cell or bone marrow transplantation. Additionally, the disease has been described in children suffering from nephroblastoma or rhabdomyosarcoma, treated with intense chemotherapy. Recently, VOD has been shown to be a complication in the treatment of myeloid leukemia with anti-CD33 linked to calicheamicin. We report the unusual case of a 21-year-old male patient with Marfan syndrome, diagnosed of acute lymphoblastic leukemia, who developed severe VOD during induction therapy after a single application of 2 mg vincristine. We speculate that coincidence of Marfan syndrome and application of induction chemotherapy might favor the disease in our patient. PMID:12761649

Kraemer, D M; Waschke, J; Kunzmann, V; Wilhelm, M

2003-07-01

447

De novo mutation in a male patient with Fabry disease: a case report  

PubMed Central

Background Fabry disease is an X-linked inherited metabolic condition where the deficit of the ?-galactosidase A enzyme, encoded by the GLA gene, leads to glycosphingolipid storage, mainly globotriaosylceramide. To date, more than 600 mutations have been identified in human GLA gene that are responsible for FD, including missense and nonsense mutations, small and large deletions. Such mutations are usually inherited, and cases of de novo onset occur rarely. Case presentation In this article we report an interesting case of a 44-year-old male patient suffering from a severe form of Fabry disease, with negative family history. The patient showed signs such as cornea verticillata, angiokeratomas, cardiac and neurological manifestations, an end-stage renal disease and he had low ?-galactosidase A activity. We detected, in this subject, the mutation c.493 G?>?C in the third exon of the GLA gene which causes the amino acid substitution D165H in the protein. This mutation affects the amino acid - belonging to the group of buried residues - involved, probably, in the preservation of the protein folding. Moreover, studies of multiple sequence alignment indicate that this amino acid is highly conserved, thus strengthening the hypothesis that it is a key amino acid to the enzyme functionality. The study of the relatives of the patient showed that, surprisingly, none of the members of his family of origin had this genetic alteration, suggesting a de novo mutation. Only his 11-year-old daughter - showing acroparaesthesias and heat intolerance with reduced enzymatic activity - had the same mutation. Conclusions We suggest that a non-inherited mutation of the ?-galactosidase A gene is responsible for Fabry disease in the patient who had reduced enzyme activity and classical clinical manifestations of the disease. In a family, it is rare to find only one Fabry disease affected subject with a de novo mutation. These findings emphasize the importance of early diagnosis, genetic counselling, studying the genealogical tree of the patients and starting enzyme replacement therapy to prevent irreversible vital organ damage that occurs during the course of the disease.

2014-01-01

448

Looking for a better future: Identity construction in socio-economically deprived 16-year olds considering a career in medicine  

Microsoft Academic Search

The medical profession has traditionally been dominated by middle-class white males in the UK, but it is a political priority to widen access to all socio-economic and ethnic groups. This paper describes an empirical study based on biographical life narrative interviews with 45 16-year olds from inner London who were considering applying to medical school, drawn mainly from the most

Nadia Robb; Lisa Dunkley; Petra Boynton; Trisha Greenhalgh

2007-01-01

449

Esophageal Adenocarcinoma in a 40-Year-Old Man With Cystic Fibrosis: Coincidence or Not?  

PubMed Central

Objective To report a case of esophageal cancer in an adult patient with cystic fibrosis (CF) and review the relationship between these 2 diseases. Case Report A 40-year-old man with CF presented with worsening epigastric pain, weight loss, and upper gastrointestinal (GI) bleeding. Endoscopy revealed innumerable masses in the distal esophagus. The workup revealed esophageal adenocarcinoma metastatic to the liver and the lungs. Discussion Abnormal mucous secretions in CF patients impair the innate GI mucosal barriers. The incidence of both gastroesophageal reflux disease and GI malignancies is higher in patients with CF. Patients with CF now survive long enough to potentially experience the consequences of long-term acid exposure, including esophagitis, Barrett esophagus, and esophageal cancer. Conclusion Our case report adds to a small but growing body of evidence that CF is a significant risk factor for GI malignancies, including esophageal adenocarcinoma. Controlled studies are needed to determine whether a causal relationship truly exists.

Holt, Edward W.; Yimam, Kidist K.; Liberman, Martin S.

2013-01-01

450

[Familial pulmonary cysts and papular skin lesions in a 37-year-old woman].  

PubMed

A 37-year-old female patient presented with sudden dyspnea and chest pain. Spontaneous pneumothoraces had been observed several times before in this patient and two members of the patient´s family in the last years. Moreover, she exhibited papular facial skin lesions. Radiomorphologically a pneumothorax apical on the left side and basal accentuated cystic lung destruction on both sides could be seen. Pleurodesis and several wedge resections with insertion of a drainage on the left side were performed therapeutically. Histology disclosed multiple cysts, whereby typical differential diagnoses could be excluded by immunohistochemistry. A molecular genetic investigation detected a heterozygous mutation in the gene coding for follikulin (FLCN). Thereby, Birt-Hogg-Dubé syndrome (BHDS) was diagnosed. BHDS follows autosomal dominant inheritance and is characterized by cystic lung lesions with recurrent pneumothoraces, cutaneous fibrofolliculomas and an increased risk of renal carcinomas. It is based on mutations in the gene coding for the protein FLCN on chromosome 17. PMID:23846428

Sander, K E; Schnabel, P A; Heußel, C P; Pfannschmidt, J; Herth, F J; Kreuter, M

2013-08-01

451

Curative resection of hilar cholangiocarcinoma in a 25-year-old woman: report of a case.  

PubMed

A 25-year-old woman was referred to our hospital with persistent upper abdominal pain. Preoperative imaging studies revealed a hilar bile duct stricture with portal venous encasement, and the patient underwent curative resection involving extended left hepatectomy and segmental portal vein resection. The pathological findings demonstrated a well-differentiated tubular adenocarcinoma of the bile duct with regional lymph node metastasis (stage IIIB according to the UICC TNM classification), as well as the overexpression of p53 proteins and the K-ras gene mutation in tumor cells. The patient has shown no evidence of recurrence in the 10 months since the operation. Although there are several reports of relatively young adults with cholangiocarcinoma, the majority of such patients demonstrate either an anomalous arrangement of the pancreaticobiliary duct system or primary sclerosing cholangitis. The absence of any morphological abnormalities in this patient's biliary system implicates de novo carcinogenesis as the most likely cause of the cholangiocarcinoma. PMID:23580078

Murakami, Sae; Ajiki, Tetsuo; Ueno, Kimihiko; Sawa, Hidehiro; Tsuchida, Shinobu; Otsubo, Izuru; Yoshida, Yuko; Shinozaki, Kenta; Okazaki, Taro; Matsumoto, Ippei; Fukumoto, Takumi; Ku, Yonson

2014-07-01

452

A 5-year-old boy with miliary and osteoarticular tuberculosis.  

PubMed

Osteoarticular involvement is one manifestation of extrapulmonary tuberculosis (TB). We present a 5-year-old Burmese boy with 10?months of right hip pain and decreased range of motion. The patient also had low-grade fever, cough and decreased appetite. The patient was undocumented and had recently moved from Myanmar. He was thin, in moderate distress with bilateral lung rhonchi, mild subcostal retractions, low back pain, right hip tenderness and painful and limited right range of motion. The patient's chest and pelvis radiographs showed a miliary pattern and right acetabulum osteolytic lesions, respectively. He was started on anti-TB medication and cefotaxime. Ofloxacin was added because of the concern of drug-resistant TB. The patient underwent a right hip debridement. His symptoms improved markedly, with improved mobility. TB is a challenging infection to diagnose, which can cause significant delays in management. PMID:24872489

Washington, Charles Henry; Oberdorfer, Peninnah

2014-01-01

453

[Therapy for male patients with sexual dysfunction].  

PubMed

Phosphodiasterase type 5 inhibitors (sildenafil, vardenafil, tadalafil) are the first line symptomatic therapy for patients with erectile dysfunction. The patient should receive a meticolous information on the use of these drugs and their possible side effects. These drugs are safe and can be used even in patients with stable cardiovascular disease. Patients not responding to oral drugs may be offered intraurethral or intracavernous alprostadil. Vacuum constriction devices are a second line option more acceptable to older patients. Penile prosthesis are very seldom used in Switzerland and vascular surgery is a vanishing option. Testosterone substitution is seldom needed in this setting. Treatment of premature ejaculation subdivides into behavioural therapy ("stop-start" or "squeeze" technique) and drug therapy as well. Topical therapy with lidocaine/prilocaine-containing medications to be applied before sexual intercourse and a oral daily off label use therapy with selective serotonin re-uptake inhibitors (paroxetine, fluoxetine, sertraline) can be offered. Dapoxetine, a potent selective serotonin reuptake inhibitor with short half life time, is the first officially approved medication for the treatment of premature ejaculation and should be available soon in Switzerland. PMID:20235039

Casella, Roberto

2010-03-01

454

A 76-year old man with a torn Freedom SOLO bioprosthesis.  

PubMed

We describe a case of a 76-year old male who presented with progressive dyspnoea. He underwent an aortic valve replacement with a Freedom SOLO bioprosthesis 6 years ago. Transthoracic echocardiography showed a moderate-to-severe leakage of the Freedom SOLO bioprosthesis. During surgical reintervention, a partial tear of the left coronary cusp was seen from the commissure of the right coronary cusp to its base. After radiographic and microscopic examination, no clear cause was found for the failure of this Freedom SOLO bioprosthesis. To our knowledge, this is the third failure of a Freedom SOLO bioprosthesis reported in the literature. When the long-term follow-up of the Freedom SOLO bioprosthesis is available, it has to be compared with other bioprosthesis for long-term durability. PMID:24144803

Wollersheim, Laurens W; Li, Wilson W; van der Meulen, Jan; de Mol, Bas A

2014-01-01

455

Walking habits and health-related factors in a 70-year-old population.  

PubMed

Walking and other physical activities were studied in a representative population sample of 619 70-year-old people in the city of Gothenburg, Sweden. Walking was the most common physical activity declared, and two thirds of those without an obvious disability walked 30 min or more every day. Subjects who took a daily walk of at least 30 min had a significantly better climbing capacity, higher bone mineral content and lower concentration of blood triglycerides than subjects who walked less. Male 'walkers' had a significantly larger lung volume than 'non-walkers'. Walkers had a more positive attitude towards physical activity as well as a higher estimation of their own physical fitness than non-walkers. PMID:1959780

Frändin, K; Grimby, G; Mellström, D; Svanborg, A

1991-01-01

456

A case of human pulmonary dirofilariasis in a 48-year-old Korean man.  

PubMed

Dirofilariasis is a rare disease in humans. We report here a case of a 48-year-old male who was diagnosed with pulmonary dirofilariasis in Korea. On chest radiographs, a coin lesion of 1 cm in diameter was shown. Although it looked like a benign inflammatory nodule, malignancy could not be excluded. So, the nodule was resected by video-assisted thoracic surgery. Pathologically, chronic granulomatous inflammation composed of coagulation necrosis with rim of fibrous tissues and granulations was seen. In the center of the necrotic nodules, a degenerating parasitic organism was found. The parasite had prominent internal cuticular ridges and thick cuticle, a well-developed muscle layer, an intestinal tube, and uterine tubules. The parasite was diagnosed as an immature female worm of Dirofilaria immitis. This is the second reported case of human pulmonary dirofilariasis in Korea. PMID:24327784

Kang, Hyo Jae; Park, Young Sik; Lee, Chang-Hoon; Lee, Sang-Min; Yim, Jae-Joon; Yoo, Chul-Gyu; Kim, Young Whan; Han, Sung Koo; Chai, Jong-Yil; Lee, Jinwoo

2013-10-01

457

An 8-year-old boy with a linear lesion on the nose.  

PubMed

CME EDUCATIONAL OBJECTIVES1.Recognize the transverse nasal crease and its association.2.Identify treatment options for milia in the nasal crease.3.Identify cutaneous findings associated with atopy in children. An 8-year-old male presented for evaluation of a lesion across his nasal bridge. This had been worsening and getting more prominent over the last 6 months. He frequently rubbed his nose with the palm of his hand due to rhinitis. His medical history was significant for asthma, allergic rhinitis, conjunctivitis, and resolved peanut allergy. He lived with his parents and was the youngest of five children. The boy's family history was significant for atopy in parents, and a sister with anaphylaxis to tree nuts. There was no family history of severe or scarring acne vulgaris. Review of systems was normal. PMID:23316817

Higgins, Alanna; Chamlin, Sarah L

2013-01-01

458

Genetic and Environmental Contributions to Sleep-Wake Behavior in 12-Year-Old Twins  

PubMed Central

Study Objectives: To examine the role of genetic and environmental factors on sleep behavior in 12-year-old twins matched for family environment. Design: Population-based twin cohort. Setting: Participants were assessed in their home environment. Patients or Participants: One hundred thirty-two adolescent twins comprising 25 monozygotic (MZ) and 41 dizygotic (DZ) twin pairs; aged 12.2 ± 0.1 y (mean ± standard deviation). Interventions: N/A. Measurements and Results: For 2 weeks in their home environment, participants wore a wrist activity monitor and completed a daily sleep diary. Sleep diaries included reports of bedtime, wake time, and estimated sleep onset time. Mean timing, duration, and quality of sleep during the 2 weeks were calculated for each individual and compared within twin pairs. MZ twin correlations were higher than the DZ correlations for total sleep time (MZr = 0.64; DZr = 0.38) and sleep onset latency (MZr = 0.83; DZr = 0.53) and significantly higher for wake after sleep onset (MZr = 0.66; DZr = 0.04) and sleep efficiency (MZr = 0.82; DZr = 0.10). Univariate modeling showed additive genetic factors accounted for 65% of the variance in total sleep time, 83% in sleep onset latency, and 52% and 57% of the variance in wake after sleep onset and sleep efficiency, respectively. A predominant influence of shared environment was found on the timing of sleep (67% for sleep start time, 86% for sleep end time). Conclusions: There is a strong genetic influence on the sleep-wake patterns of 12-year-old adolescents. Genes have a greater influence on sleep initiation and sleep maintenance and a smaller role in sleep timing, likely to be influenced by family environment. Citation: Sletten TL; Rajaratnam SMW; Wright MJ; Zhu G; Naismith S; Martin NG; Hickie I. Genetic and environmental contributions to sleep-wake behavior in 12-year-old twins. SLEEP 2013;36(11):1715-1722.

Sletten, Tracey L.; Rajaratnam, Shantha M.W.; Wright, Margaret J.; Zhu, Gu; Naismith, Sharon; Martin, Nicholas G.; Hickie, Ian

2013-01-01

459

Perinatal characteristics among early (10-14 years old) and late (15-19 years old) pregnant adolescents  

PubMed Central

Background Pregnancy in adolescents is a worldwide health problem and has been mostly common in poor populations. It is not clear if socioeconomic or biological factors are the main determinants of perinatal adverse outcomes in pregnant adolescents. Adolescents under 15 years old may present a high growth rate which may contribute to impair fetal growth. Our aim is to compare perinatal characteristics among early (aged 10 to 14 years) and late (aged 15 to 19 years) pregnant adolescents. Methods A cross-sectional study was performed using data from Pernambuco State 2009, obtained from DATASUS/SISNAC, a Brazilian Government, open-access public health database. Maternal and neonatal outcomes were compared between early (aged 10–14 years) and late (aged 15–19 years) pregnant adolescents. Family income was compared between early and late pregnant adolescents using a sample of 412 subjects evaluated at Instituto de Medicina Integral Prof. Fernando Figueira (IMIP) during 2011. Statistical comparisons were made using the chi-square test was used with a significant level of 0.05; bivariate and multivariate analysis were performed. This project was approved by the Institutional Ethics Review Board. Results Data from 31,209 pregnant adolescents were analyzed. 29,733 (95.2%) were aged 15 to 19 years and 1,476 (4.7%) were aged 10 to 14 years. There were significant differences with respect to marital status, education level and number of prenatal visits of mothers aged 10 to 14 years compared to 15 to 19 years. Of importance, early adolescents had a greater rate of neonates born premature and with low birth weight. Prematurity and low birth weight remained statistically significant after multivariate analysis. Conclusions Early aged adolescents may have an increased risk of prematurity and low birth weight. These findings highlight the potential role of biological factors in newborn outcomes in pregnant adolescents.

2012-01-01

460

Malignant Fibrous Histiocytoma of the Breast in Young Male Patient: A Case Report and a Review of the Literature  

PubMed Central

Malignant Fibrous Histiocytoma (MFH) is a fairly common tumor in the deep soft tissues: the most frequent primary sites are the lower (49%) and upper (19%) limbs, but it has been reported even in the retroperitoneum and abdomen (16%), while localization in the breast is extremely rare (1-2). Breast cancer is rarely seen in males, accounts for approximately 1% of all breast cancer, and the breast sarcomas constitute less than 1% of breast tumors in both sexes. In the review of the literature, this is the third male and first young male with MFH. Here, we present a 37-years-old male patient who is diagnosed to have malignant fibrous histiocytoma in a variant of pleomorphic fusiform cell localized in the left breast. Following the wide local excision, the patient was given an adjuvant 50?Gy of external radiotherapy. He remained alive and well after 42 months of followup. We believe that reporting such few cases would contribute to forming treatment algorithms of rare tumors.

Kocak Uzel, Esengul; Figen, Metin; Bek, Tuba Tulin; Inanc, Kubilay; Onder, Senem; Kizilkaya, Hazim orhan

2013-01-01