Science.gov

Sample records for yielded significant findings

  1. 10 CFR 51.32 - Finding of no significant impact.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 2 2011-01-01 2011-01-01 false Finding of no significant impact. 51.32 Section 51.32... Section 102(2) Finding of No Significant Impact § 51.32 Finding of no significant impact. (a) A finding of no significant impact will: (1) Identify the proposed action; (2) State that the Commission...

  2. 10 CFR 51.32 - Finding of no significant impact.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Finding of no significant impact. 51.32 Section 51.32... Section 102(2) Finding of No Significant Impact § 51.32 Finding of no significant impact. (a) A finding of no significant impact will: (1) Identify the proposed action; (2) State that the Commission...

  3. 40 CFR 1508.13 - Finding of no significant impact.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 33 2011-07-01 2011-07-01 false Finding of no significant impact. 1508... § 1508.13 Finding of no significant impact. Finding of no significant impact means a document by a... have a significant effect on the human environment and for which an environmental impact...

  4. 40 CFR 1508.13 - Finding of no significant impact.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 32 2010-07-01 2010-07-01 false Finding of no significant impact. 1508... § 1508.13 Finding of no significant impact. Finding of no significant impact means a document by a... have a significant effect on the human environment and for which an environmental impact...

  5. 16 CFR 1021.13 - Finding of no significant impact.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 16 Commercial Practices 2 2010-01-01 2010-01-01 false Finding of no significant impact. 1021.13... Contents of Environmental Review Documents § 1021.13 Finding of no significant impact. (a) A finding of no significant impact shall cite and be attached to the environmental assessment upon which it is based. It...

  6. Sonocrystallization yields monoclinic paracetamol with significantly improved compaction behavior.

    PubMed

    Bučar, Dejan-Krešimir; Elliott, James A; Eddleston, Mark D; Cockcroft, Jeremy K; Jones, William

    2015-01-01

    Ultrasound-assisted crystallization (sonocrystallization) was used to prepare a mixture of nano- and micrometer-sized crystals of the monoclinic form of paracetamol-a widely used analgesic known for its particularly problematic mechanical behavior under compression (i.e. poor tabletability). The nano- and micrometer-sized crystals yielded a powder which exhibits elastic moduli and bulk cohesions that are significantly higher than those observed in samples consisting of macrometer-sized crystals, thus leading to enhanced tabletability without the use of excipients, particle coating, salt, or cocrystal formation. Experimental compaction and finite element analysis were utilized to rationalize the significantly improved compaction behavior of the monoclinic form of paracetamol. PMID:25370777

  7. 32 CFR 651.21 - Finding of no significant impact.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 32 National Defense 4 2011-07-01 2011-07-01 false Finding of no significant impact. 651.21 Section... of no significant impact. A Finding of No Significant Impact (FNSI) is a document that briefly states... comments, the proponent forwards a decision package that includes a comparison of environmental...

  8. 32 CFR 651.21 - Finding of no significant impact.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 32 National Defense 4 2010-07-01 2010-07-01 true Finding of no significant impact. 651.21 Section... of no significant impact. A Finding of No Significant Impact (FNSI) is a document that briefly states... comments, the proponent forwards a decision package that includes a comparison of environmental...

  9. 46 CFR 504.6 - Finding of no significant impact.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 9 2010-10-01 2010-10-01 false Finding of no significant impact. 504.6 Section 504.6... POLICY ANALYSIS § 504.6 Finding of no significant impact. (a) If upon completion of an environmental assessment, it is determined that a potential or proposed action will not have a significant impact on...

  10. 76 FR 68260 - Availability of Finding of No Significant Impact

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-03

    ... interested parties the Finding of No Significant Impact (FONSI) for the United States Merchant Marine Academy Mallory Pier Replacement project. An environmental assessment (EA) and FONSI have been prepared...

  11. Unexpected Findings in Magnetic Resonance Enterography and Their Clinical Significance

    PubMed Central

    Ravindran, Srivathsan; Hancox, Sarah Helen; Barlow, Neil; Dunk, Arthur; Howlett, David

    2016-01-01

    Aims. To identify the prevalence of colonic and extraenteric incidental findings in magnetic resonance enterography (MRE) and their clinical significance. Methods. We retrospectively analysed 470 MRE studies carried out between March 2012 and 2014. Incidental findings were defined as those not expected from or made apparent on the referral. MRE reports were reviewed for colonic and extraenteric findings, subcategorised into “clinically significant” and “insignificant.” Follow-up was identified from the electronic patient record. Results. The majority of MRE requests were made for inflammatory bowel disease (97%). In total, 114 incidental findings were noted in 94 (20%) scans performed. There were 29 “colonic” findings (25%) with 55% having a diagnosis of colitis. Out of 85 extraenteric findings, ovarian cysts (25%), renal cysts (10%), and abdominal lymphadenopathy (9%) were the commonest. Cumulatively, 59 cases were clinically significant (52%); of these, 30 findings were not previously diagnosed, amounting to 26% of all incidental findings. This led to intervention in seven patients. Conclusions. Incidental findings are common in MRE and there is a substantial proportion that is clinically significant and requires further investigation. There need to be stratification of risk and employment of local guidelines in order to achieve this. PMID:27446837

  12. 40 CFR 6.206 - Findings of no significant impact.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Responsible Official may issue a finding of no significant impact (FONSI) (see 40 CFR 1508.13) only if the EA.... If the EA does not support a FONSI, the Responsible Official must prepare an EIS and issue a ROD before taking action on the proposed action. (b) Consistent with 40 CFR 1508.13, a FONSI must include:...

  13. 40 CFR 6.206 - Findings of no significant impact.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Responsible Official may issue a finding of no significant impact (FONSI) (see 40 CFR 1508.13) only if the EA.... If the EA does not support a FONSI, the Responsible Official must prepare an EIS and issue a ROD before taking action on the proposed action. (b) Consistent with 40 CFR 1508.13, a FONSI must include:...

  14. 40 CFR 6.206 - Findings of no significant impact.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Responsible Official may issue a finding of no significant impact (FONSI) (see 40 CFR 1508.13) only if the EA.... If the EA does not support a FONSI, the Responsible Official must prepare an EIS and issue a ROD before taking action on the proposed action. (b) Consistent with 40 CFR 1508.13, a FONSI must include:...

  15. 40 CFR 6.206 - Findings of no significant impact.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Responsible Official may issue a finding of no significant impact (FONSI) (see 40 CFR 1508.13) only if the EA.... If the EA does not support a FONSI, the Responsible Official must prepare an EIS and issue a ROD before taking action on the proposed action. (b) Consistent with 40 CFR 1508.13, a FONSI must include:...

  16. 40 CFR 6.206 - Findings of no significant impact.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Responsible Official may issue a finding of no significant impact (FONSI) (see 40 CFR 1508.13) only if the EA.... If the EA does not support a FONSI, the Responsible Official must prepare an EIS and issue a ROD before taking action on the proposed action. (b) Consistent with 40 CFR 1508.13, a FONSI must include:...

  17. 23 CFR 771.121 - Findings of no significant impact.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... incorporating the other agency's FONSI. If environmental issues have not been adequately identified and assessed... ENVIRONMENTAL IMPACT AND RELATED PROCEDURES § 771.121 Findings of no significant impact. (a) The Administration... written FONSI incorporating by reference the EA and any other appropriate environmental documents....

  18. 23 CFR 771.121 - Findings of no significant impact.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... incorporating the other agency's FONSI. If environmental issues have not been adequately identified and assessed... ENVIRONMENTAL IMPACT AND RELATED PROCEDURES § 771.121 Findings of no significant impact. (a) The Administration... written FONSI incorporating by reference the EA and any other appropriate environmental documents....

  19. 23 CFR 771.121 - Findings of no significant impact.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... incorporating the other agency's FONSI. If environmental issues have not been adequately identified and assessed... ENVIRONMENTAL IMPACT AND RELATED PROCEDURES § 771.121 Findings of no significant impact. (a) The Administration... written FONSI incorporating by reference the EA and any other appropriate environmental documents....

  20. 23 CFR 771.121 - Findings of no significant impact.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... incorporating the other agency's FONSI. If environmental issues have not been adequately identified and assessed... ENVIRONMENTAL IMPACT AND RELATED PROCEDURES § 771.121 Findings of no significant impact. (a) The Administration... written FONSI incorporating by reference the EA and any other appropriate environmental documents....

  1. 10 CFR 1021.322 - Findings of no significant impact.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Findings of no significant impact. 1021.322 Section 1021.322 Energy DEPARTMENT OF ENERGY (GENERAL PROVISIONS) NATIONAL ENVIRONMENTAL POLICY ACT IMPLEMENTING... this part; (2) Any “Statement of Findings” required by 10 CFR part 1022, “Compliance with...

  2. 10 CFR 1021.322 - Findings of no significant impact.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 4 2012-01-01 2012-01-01 false Findings of no significant impact. 1021.322 Section 1021.322 Energy DEPARTMENT OF ENERGY (GENERAL PROVISIONS) NATIONAL ENVIRONMENTAL POLICY ACT IMPLEMENTING... this part; (2) Any “Statement of Findings” required by 10 CFR part 1022, “Compliance with...

  3. 10 CFR 1021.322 - Findings of no significant impact.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 10 Energy 4 2014-01-01 2014-01-01 false Findings of no significant impact. 1021.322 Section 1021.322 Energy DEPARTMENT OF ENERGY (GENERAL PROVISIONS) NATIONAL ENVIRONMENTAL POLICY ACT IMPLEMENTING... this part; (2) Any “Statement of Findings” required by 10 CFR part 1022, “Compliance with...

  4. 10 CFR 1021.322 - Findings of no significant impact.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 4 2011-01-01 2011-01-01 false Findings of no significant impact. 1021.322 Section 1021.322 Energy DEPARTMENT OF ENERGY (GENERAL PROVISIONS) NATIONAL ENVIRONMENTAL POLICY ACT IMPLEMENTING... this part; (2) Any “Statement of Findings” required by 10 CFR part 1022, “Compliance with...

  5. Genetic Diversity and Soybean Yield: Finding the Balance

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Based on national production statistics since 1924, average soybean yield in the U.S. has increased at a nearly steady rate of 22 kg ha-1 year-1. It is possible to show some changes in this rate depending on how these past 85 years are divided, but two conclusions seem evident. Soybean yield has not...

  6. Patellar tendinitis: the significance of magnetic resonance imaging findings.

    PubMed

    Shalaby, M; Almekinders, L C

    1999-01-01

    We evaluated the significance of magnetic resonance imaging findings in patients with patellar tendinitis. Midline sagittal magnetic resonance images were taken of 12 knees from 10 patients and of 17 knees from 15 age- and activity-matched subjects who underwent imaging for reasons other than patellar tendinitis. Of the 12 magnetic resonance imaging scans of knees with clinical patellar tendinitis, 3 (25%) exhibited no defect and only 7 (58%) had unequivocal intratendinous lesions. Among the 17 scans of subjects without clinical patellar tendinitis, 5 (34%) showed no defect and 4 (24%) had unequivocal intratendinous lesions. Proximal tendon width was significantly larger for the tendinitis patient group (5.0 +/- 1.7 mm versus 3.9 +/- 1.0 mm), although considerable overlap was present. All subjects with unequivocal intratendinous signal changes had a significantly longer nonarticular inferior patellar pole and were significantly older (38.1 years versus 26.8 years). Only Blazina stage III lesions were associated with abnormal findings on magnetic resonance imaging. As a whole, the sensitivity and specificity of magnetic resonance imaging was 75% and 29%, respectively. In younger patients with relatively mild symptoms, magnetic resonance imaging did not show significant changes; in older, active patients changes may be present in asymptomatic knees. PMID:10352771

  7. Finding significantly connected voxels based on histograms of connection strengths

    NASA Astrophysics Data System (ADS)

    Kasenburg, Niklas; Pedersen, Morten Vester; Darkner, Sune

    2016-03-01

    We explore a new approach for structural connectivity based segmentations of subcortical brain regions. Connectivity based segmentations are usually based on fibre connections from a seed region to predefined target regions. We present a method for finding significantly connected voxels based on the distribution of connection strengths. Paths from seed voxels to all voxels in a target region are obtained from a shortest-path tractography. For each seed voxel we approximate the distribution with a histogram of path scores. We hypothesise that the majority of estimated connections are false-positives and that their connection strength is distributed differently from true-positive connections. Therefore, an empirical null-distribution is defined for each target region as the average normalized histogram over all voxels in the seed region. Single histograms are then tested against the corresponding null-distribution and significance is determined using the false discovery rate (FDR). Segmentations are based on significantly connected voxels and their FDR. In this work we focus on the thalamus and the target regions were chosen by dividing the cortex into a prefrontal/temporal zone, motor zone, somatosensory zone and a parieto-occipital zone. The obtained segmentations consistently show a sparse number of significantly connected voxels that are located near the surface of the anterior thalamus over a population of 38 subjects.

  8. Physics of Hard Spheres Experiment: Significant and Quantitative Findings Made

    NASA Technical Reports Server (NTRS)

    Doherty, Michael P.

    2000-01-01

    Direct examination of atomic interactions is difficult. One powerful approach to visualizing atomic interactions is to study near-index-matched colloidal dispersions of microscopic plastic spheres, which can be probed by visible light. Such spheres interact through hydrodynamic and Brownian forces, but they feel no direct force before an infinite repulsion at contact. Through the microgravity flight of the Physics of Hard Spheres Experiment (PHaSE), researchers have sought a more complete understanding of the entropically driven disorder-order transition in hard-sphere colloidal dispersions. The experiment was conceived by Professors Paul M. Chaikin and William B. Russel of Princeton University. Microgravity was required because, on Earth, index-matched colloidal dispersions often cannot be density matched, resulting in significant settling over the crystallization period. This settling makes them a poor model of the equilibrium atomic system, where the effect of gravity is truly negligible. For this purpose, a customized light-scattering instrument was designed, built, and flown by the NASA Glenn Research Center at Lewis Field on the space shuttle (shuttle missions STS 83 and STS 94). This instrument performed both static and dynamic light scattering, with sample oscillation for determining rheological properties. Scattered light from a 532- nm laser was recorded either by a 10-bit charge-coupled discharge (CCD) camera from a concentric screen covering angles of 0 to 60 or by sensitive avalanche photodiode detectors, which convert the photons into binary data from which two correlators compute autocorrelation functions. The sample cell was driven by a direct-current servomotor to allow sinusoidal oscillation for the measurement of rheological properties. Significant microgravity research findings include the observation of beautiful dendritic crystals, the crystallization of a "glassy phase" sample in microgravity that did not crystallize for over 1 year in 1g

  9. The significance of Candida pulcherrima findings in human clinical specimens.

    PubMed

    Pospisil, L

    1989-11-01

    From 1971 to 1976 the author examined by cultivation on Sabouraud glucose agar, 1720 specimens of the most varied materials--skin scales, nails, hair, beard, sputum--obtained from patients suffering from skin problems. In no one single case did he find Candida pulcherrima. However, since 1977 he has found C. pulcherrima to be on an increase. From 1977 to 1984 in 4644 specimens C. pulcherrima was found in 44 cases. 38 strains, i.e. 86%, were isolated from patients with clinical diagnosis of mycotic infection. The most frequent diagnosis was onychomycosis, 36%. Cultivation findings were mostly profuse and massive relative to the number of germs, in some patients even occurring repeatedly. In view of these findings it may be necessary to revise the views purporting the finding of C. pulcherrima from human material to be insignificant. PMID:2615783

  10. 32 CFR 989.15 - Finding of no significant impact.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... FONSI (40 CFR 1508.13) briefly describes why an action would not have a significant effect on the environment and thus will not be the subject of an EIS. The FONSI must summarize the EA or, preferably, have... the action (40 CFR 1501.4(e)(2)): (i) When the proposed action is, or is closely similar to, one...

  11. 32 CFR 989.15 - Finding of no significant impact.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... FONSI (40 CFR 1508.13) briefly describes why an action would not have a significant effect on the environment and thus will not be the subject of an EIS. The FONSI must summarize the EA or, preferably, have... the action (40 CFR 1501.4(e)(2)): (i) When the proposed action is, or is closely similar to, one...

  12. 32 CFR 989.15 - Finding of no significant impact.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... FONSI (40 CFR 1508.13) briefly describes why an action would not have a significant effect on the environment and thus will not be the subject of an EIS. The FONSI must summarize the EA or, preferably, have... the action (40 CFR 1501.4(e)(2)): (i) When the proposed action is, or is closely similar to, one...

  13. 32 CFR 989.15 - Finding of no significant impact.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 989.15 National Defense Department of Defense (Continued) DEPARTMENT OF THE AIR FORCE ENVIRONMENTAL... FONSI (40 CFR 1508.13) briefly describes why an action would not have a significant effect on the... the action (40 CFR 1501.4(e)(2)): (i) When the proposed action is, or is closely similar to, one...

  14. 32 CFR 989.15 - Finding of no significant impact.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 989.15 National Defense Department of Defense (Continued) DEPARTMENT OF THE AIR FORCE ENVIRONMENTAL... FONSI (40 CFR 1508.13) briefly describes why an action would not have a significant effect on the... the action (40 CFR 1501.4(e)(2)): (i) When the proposed action is, or is closely similar to, one...

  15. Finding Significant Correlates of Conscious Activity in Rhythmic EEG

    NASA Astrophysics Data System (ADS)

    Durka, Piotr J.

    2005-12-01

    One of the important issues in designing an EEG-based brain-computer interface is an exact delineation of the rhythms, related to the intended or performed action. Traditionally, related bands were found by trial and error procedures seeking maximum reactivity. Even then, large values of ERD/ERS did not imply the statistical significance of the results. This paper presents complete methodology, allowing for a high-resolution presentation of the whole time-frequency picture of event-related changes in the energy density of signals, revealing the microstructure of rhythms, and determination of the time-frequency regions of energy changes, which are related to the intentions in a statistically significant way.

  16. Significance of smoking machine toxicant yields to blood-level exposure in waterpipe tobacco smokers

    PubMed Central

    Shihadeh, Alan L.; Eissenberg, Thomas E.

    2014-01-01

    Background The global rise in tobacco smoking using a waterpipe (hookah, narghile, shisha) has made understanding its health consequences imperative. One key to developing this understanding is identifying and quantifying carcinogens and other toxicants present in waterpipe smoke. To do so, the toxicant yield of machine-generated waterpipe smoke has been measured. However, the relevance of toxicant yields of machine-generated smoke to actual human exposure has not been established. Methods In this study, we examined whether CO and nicotine yields measured using a smoking machine programmed to replicate the puffing behavior of 31 human participants who smoked a waterpipe could reliably predict these participant’s blood-level exposure. In addition to CO and nicotine, yields of PAH, volatile aldehydes, NO, and “tar” were measured. Results We found that when used in this puff-replicating manner, smoking machine yields are highly correlated with blood-level exposure (Nicotine: r>0.76, p<0.001; CO: r>0.78, p<0.001). Total drawn smoke volume was the best predictor of toxicant yield and exposure, accounting for approximately 75–100% of the variability across participants in yields of NO, CO, volatile aldehydes and “tar”, and blood-level CO and normalized nicotine. Conclusions Machine-based methods can be devised in which smoke toxicant yields reliably track human exposure. Impact This finding indicates the basic feasibility of valid analytical laboratory evaluation of tobacco products for regulatory purposes. PMID:21914836

  17. 10 CFR 51.34 - Preparation of finding of no significant impact.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 2 2011-01-01 2011-01-01 false Preparation of finding of no significant impact. 51.34... Implementing Section 102(2) Finding of No Significant Impact § 51.34 Preparation of finding of no significant impact. (a) Except as provided in paragraph (b) of this section, the finding of no significant...

  18. Analysis of a large dataset of mycorrhiza inoculation field trials on potato shows highly significant increases in yield.

    PubMed

    Hijri, Mohamed

    2016-04-01

    An increasing human population requires more food production in nutrient-efficient systems in order to simultaneously meet global food needs while reducing the environmental footprint of agriculture. Arbuscular mycorrhizal fungi (AMF) have the potential to enhance crop yield, but their efficiency has yet to be demonstrated in large-scale crop production systems. This study reports an analysis of a dataset consisting of 231 field trials in which the same AMF inoculant (Rhizophagus irregularis DAOM 197198) was applied to potato over a 4-year period in North America and Europe under authentic field conditions. The inoculation was performed using a liquid suspension of AMF spores that was sprayed onto potato seed pieces, yielding a calculated 71 spores per seed piece. Statistical analysis showed a highly significant increase in marketable potato yield (ANOVA, P < 0.0001) for inoculated fields (42.2 tons/ha) compared with non-inoculated controls (38.3 tons/ha), irrespective of trial year. The average yield increase was 3.9 tons/ha, representing 9.5 % of total crop yield. Inoculation was profitable with a 0.67-tons/ha increase in yield, a threshold reached in almost 79 % of all trials. This finding clearly demonstrates the benefits of mycorrhizal-based inoculation on crop yield, using potato as a case study. Further improvements of these beneficial inoculants will help compensate for crop production deficits, both now and in the future. PMID:26403242

  19. 10 CFR 51.33 - Draft finding of no significant impact; distribution.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 2 2011-01-01 2011-01-01 false Draft finding of no significant impact; distribution. 51...-Regulations Implementing Section 102(2) Finding of No Significant Impact § 51.33 Draft finding of no significant impact; distribution. (a) As provided in paragraph (b) of this section, the appropriate NRC...

  20. Simple Machine Perfusion Significantly Enhances Hepatocyte Yields of Ischemic and Fresh Rat Livers

    PubMed Central

    Izamis, Maria-Louisa; Calhoun, Candice; Uygun, Basak E.; Guzzardi, Maria Angela; Price, Gavrielle; Luitje, Martha; Saeidi, Nima; Yarmush, Martin L.; Uygun, Korkut

    2013-01-01

    The scarcity of viable hepatocytes is a significant bottleneck in cell transplantation, drug discovery, toxicology, tissue engineering, and bioartificial assist devices, where trillions of high-functioning hepatocytes are needed annually. We took the novel approach of using machine perfusion to maximize cell recovery, specifically from uncontrolled cardiac death donors, the largest source of disqualified donor organs. In a rat model, we developed a simple 3-h room temperature (20 ± 2°C) machine perfusion protocol to treat nonpremedicated livers exposed to 1 h of warm (34°C) ischemia. Treated ischemic livers were compared to fresh, fresh-treated, and untreated ischemic livers using viable hepatocyte yields and in vitro performance as quantitative endpoints. Perfusion treatment resulted in both a 25-fold increase in viable hepatocytes from ischemic livers and a 40% increase from fresh livers. While cell morphology and function in suspension and plate cultures of untreated warm ischemic cells was significantly impaired, treated warm ischemic cells were indistinguishable from fresh hepatocytes. Furthermore, a strong linear correlation between tissue ATP and cell yield enabled accurate evaluation of the extent of perfusion recovery. Maximal recovery of warm ischemic liver ATP content appears to be correlated with optimal flow through the microvasculature. These data demonstrate that the inclusion of a simple perfusion-preconditioning step can significantly increase the efficiency of functional hepatocyte yields and the number of donor livers that can be gainfully utilized. PMID:25431743

  1. Paraoxonase-1 activity determination via paraoxon substrate yields no significant difference in mild hyperhomocysteinemia.

    PubMed

    Türkeli, Hatice; Caycı, Tuncer; Akgül, Emin Özgür; Macit, Enis; Yaman, Halil; Aydın, Ibrahim; Demirin, Hilmi; Alacam, Hasan; Ozkan, Esin; Cakır, Erdinç; Deren, Ozgür; Erbil, Mehmet Kemal; Kunak, Z Ilker; Burat, Kutlay; Akman, Serif

    2010-11-01

    Elevated plasma homocystein (Hcy) level has been recognized as an important risk factor for a number of cardiovascular diseases, peripheral arterial occlusive disease and venous thrombosis. A part of Hcy in the organism is turned to homocysteine thiolactone (HcyT) via a ring closure reaction, which gains rate in hyperhomocysteinemia, and in turn undergoes a hydrolytic reaction back to Hcy by paraoxonase enzyme (PON). Since this is a protective reflex action enzyme against hyperhomocysteinemia, we investigated how a mild hyperhomocysteinemic nutritional habit affected serum PON activity in a population-based study. The difference detected via enzymatic activity using the paraoxon substrate was statistically non-significant (p=0.19), suggesting a defective performance to reflect the expected significance. Determination of serum PON activity via substrate paraoxon yielded no significant difference in an acute mild hyperhomocysteinemic diet model in humans. PMID:19419786

  2. Low level of basal testosterone: a significant risk factor for poor oocyte yield after ovulation induction.

    PubMed

    Guo, Jing; Zhang, Qingxue; Li, Yu; Wang, Wenjun; Yang, Dongzi

    2016-03-01

    The objective of this study was to further investigate the association of low androgen levels and poor ovarian response or negative pregnancy outcome in in vitro fertilisation treatment using a retrospective cohort study. Chinese women (n=1950) of relatively young age, with normal range of basal FSH and antral follicle count undergoing an in vitro fertilisation cycle were selected and testosterone and dehydroepiandrosterone sulfate levels were measured on Day 3 of the menstrual cycle before subsequent in vitro fertilisation treatment. The main outcome measures of the study were ovarian stimulation parameters and clinical pregnancy. Basal testosterone levels of poor responders and non-pregnant women were significantly lower than normal responders and pregnant women, respectively. Patients with low basal testosterone levels had significantly lower number of mature oocytes, cleavage-stage embryos, frozen embryos, lower fertilisation and pregnancy rates and required higher doses of gonadotrophins. Androgen levels had no correlation with early spontaneous abortion rates. Multivariable logistic analysis revealed that low basal testosterone (<0.88nmolL(-1)) was an independent risk factor for poor oocyte yield (odds ratio: 1.61; 95% confidence interval: 1.01-2.57; P=0.045). In conclusion, a low level of basal testosterone was a significant risk factor for poor oocyte yield after ovarian stimulation and might negatively influence pregnancy chances with in vitro fertilisation. Basal dehydroepiandrosterone sulfate levels were not predictive for poor ovarian response or negative pregnancy outcome in this population. PMID:25023952

  3. Enhancing the Interpretation of "Significant" Findings: The Role of Mixed Methods Research

    ERIC Educational Resources Information Center

    Onwuegbuzie, Anthony J.; Leech, Nancy L.

    2004-01-01

    The present essay outlines how mixed methods research can be used to enhance the interpretation of significant findings. First, we define what we mean by significance in educational evaluation research. With regard to quantitative-based research, we define the four types of significance: statistical significance, practical significance, clinical…

  4. 7 CFR Exhibit I to Subpart G of... - Finding of No Significant Environmental Impact

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... human environment. Therefore, the preparation of an environmental impact statement is not necessary. I... 7 Agriculture 13 2011-01-01 2009-01-01 true Finding of No Significant Environmental Impact I... Environmental Impact SUBJECT: Finding of No Significant Environmental Impact and Necessary...

  5. 78 FR 50026 - Energy Efficiency and Conservation Loan Program Finding of No Significant Impact

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-16

    ... Rural Utilities Service Energy Efficiency and Conservation Loan Program Finding of No Significant Impact... (RUS) has made a finding of no significant impact (FONSI) for implementing its new Energy Efficiency... 12 to authorize energy audits and energy efficiency measures and devices to reduce demand on...

  6. 7 CFR Exhibit I to Subpart G of... - Finding of No Significant Environmental Impact

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 13 2014-01-01 2013-01-01 true Finding of No Significant Environmental Impact I... Environmental Impact SUBJECT: Finding of No Significant Environmental Impact and Necessary Environmental... attached environmental assessment has been completed for the subject proposal by the FmHA or its...

  7. 7 CFR Exhibit I to Subpart G of... - Finding of No Significant Environmental Impact

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... human environment. Therefore, the preparation of an environmental impact statement is not necessary. I... 7 Agriculture 13 2012-01-01 2012-01-01 false Finding of No Significant Environmental Impact I... Environmental Impact SUBJECT: Finding of No Significant Environmental Impact and Necessary...

  8. 7 CFR Exhibit I to Subpart G of... - Finding of No Significant Environmental Impact

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... human environment. Therefore, the preparation of an environmental impact statement is not necessary. I... 7 Agriculture 13 2013-01-01 2013-01-01 false Finding of No Significant Environmental Impact I... Environmental Impact SUBJECT: Finding of No Significant Environmental Impact and Necessary...

  9. Significant enhancement of negative secondary ion yields by cluster ion bombardment combined with cesium flooding.

    PubMed

    Philipp, Patrick; Angerer, Tina B; Sämfors, Sanna; Blenkinsopp, Paul; Fletcher, John S; Wirtz, Tom

    2015-10-01

    In secondary ion mass spectrometry (SIMS), the beneficial effect of cesium implantation or flooding on the enhancement of negative secondary ion yields has been investigated in detail for various semiconductor and metal samples. All results have been obtained for monatomic ion bombardment. Recent progress in SIMS is based to a large extent on the development and use of cluster primary ions. In this work we show that the enhancement of negative secondary ions induced by the combination of ion bombardment with simultaneous cesium flooding is valid not only for monatomic ion bombardment but also for cluster primary ions. Experiments carried out using C60+ and Ar4000+ bombardment on silicon show that yields of negative secondary silicon ions can be optimized in the same way as by Ga+ and Cs+ bombardment. Both for monatomic and cluster ion bombardment, the optimization does not depend on the primary ion species. Hence, it can be assumed that the silicon results are also valid for other cluster primary ions and that results obtained for monatomic ion bombardment on other semiconductor and metal samples are also valid for cluster ion bombardment. In SIMS, cluster primary ions are also largely used for the analysis of organic matter. For polycarbonate, our results show that Ar4000+ bombardment combined with cesium flooding enhances secondary ion signals by a factor of 6. This can be attributed to the removal of charging effects and/or reduced fragmentation, but no major influence on ionization processes can be observed. The use of cesium flooding for the imaging of cells was also investigated and a significant enhancement of secondary ion yields was observed. Hence, cesium flooding has also a vast potential for SIMS analyses with cluster ion bombardment. PMID:26378890

  10. Cytologic findings and diagnostic yield in 92 dogs undergoing fine-needle aspiration of the pancreas.

    PubMed

    Cordner, Amy P; Sharkey, Leslie C; Armstrong, P Jane; McAteer, Kaitlyn D

    2015-03-01

    The diagnosis of pancreatic disease in small animal veterinary patients is complicated by nonspecific clinical signs and the limitations of diagnostic testing. Pancreatic cytology is a potential diagnostic tool, but safety and diagnostic yield are not well characterized in large patient cohorts. We hypothesized that pancreatic fine-needle aspiration (FNA) in dogs would frequently generate diagnostic-quality samples and subsequent adverse medical events would be uncommon. Ninety-two client-owned dogs undergoing pancreatic FNA for clinical diagnostic evaluation were identified retrospectively by a computer search for pancreatic cytology submissions. Archived slides were reviewed by a single board-certified clinical pathologist using a predetermined descriptive scheme. Medical records were reviewed for adverse events 48 hr following FNA, for concurrent procedures and diagnosis in patients with adverse events and for histology results. Diagnostic yield was calculated as the % cases in which a cytologic diagnosis could be achieved; correlation with histology or other confirmatory testing was determined when possible. Diagnostic yield was 73.5%, and the major pathologic process identified cytologically correlated with confirmatory testing in 10 out of 11 cases. There were 7 adverse events, all in dogs with significant comorbidities or undergoing other invasive procedures. Pancreatic FNA in dogs has a good diagnostic yield and a low rate of clinical complications in a large case series of dogs. Correlation of cytology and histology results was high in a limited number of cases. PMID:25776547

  11. 76 FR 80366 - Availability of an Environmental Assessment (EA) and Finding of No Significant Impact (FONSI)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-23

    ... issues and reasonable alternatives to be addressed in the EA. 76 FR 22882. The environmental review... AGENCY Availability of an Environmental Assessment (EA) and Finding of No Significant Impact (FONSI) AGENCY: Environmental Protection Agency (EPA). ACTION: Environmental Assessment (EA)/Finding of...

  12. 7 CFR Exhibit I to Subpart G of... - Finding of No Significant Environmental Impact

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 13 2010-01-01 2009-01-01 true Finding of No Significant Environmental Impact I Exhibit I to Subpart G of Part 1940 Agriculture Regulations of the Department of Agriculture (Continued... Program Pt. 1940, Subpt. G, Exh. I Exhibit I to Subpart G of Part 1940—Finding of No...

  13. Neoadjuvant chemotherapy in breast cancer significantly reduces number of yielded lymph nodes by axillary dissection

    PubMed Central

    2014-01-01

    Background Neoadjuvant chemotherapy (NC) is an established therapy in breast cancer, able to downstage positive axillary lymph nodes, but might hamper their detectibility. Even if clinical observations suggest lower lymph node yield (LNY) after NC, data are inconclusive and it is unclear whether NC dependent parameters influence detection rates by axillary lymph node dissection (ALND). Methods We analyzed retrospectively the LNY in 182 patients with ALND after NC and 351 patients with primary ALND. Impact of surgery or pathological examination and specific histomorphological alterations were evaluated. Outcome analyses regarding recurrence rates, disease free (DFS) and overall survival (OS) were performed. Results Axillary LNY was significantly lower in the NC in comparison to the primary surgery group (median 13 vs. 16; p < 0.0001). The likelihood of incomplete axillary staging was four times higher in the NC group (14.8% vs. 3.4%, p < 0.0001). Multivariate analyses excluded any influence by surgeon or pathologist. However, the chemotherapy dependent histological feature lymphoid depletion was an independent predictive factor for a lower LNY. Outcome analyses revealed no significant impact of the LNY on local and regional recurrence rates as well as DFS and OS, respectively. Conclusion NC significantly reduces the LNY by ALND and has profound effects on the histomorphological appearance of lymph nodes. The current recommendations for a minimum removal of 10 lymph nodes by ALND are clearly compromised by the clinically already established concept of NC. The LNY of less than 10 by ALND after NC might not be indicative for an insufficient axillary staging. PMID:24386929

  14. 76 FR 19523 - Finding of No Significant Impact (FONSI) for the Beaumont Layberth Facility

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-07

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF TRANSPORTATION Maritime Administration Finding of No Significant Impact (FONSI) for the Beaumont Layberth Facility AGENCY... Significant Impact (FONSI) for the Beaumont Layberth Facility. An environmental assessment (EA) and FONSI...

  15. Soil mulching significantly enhances yields and water and nitrogen use efficiencies of maize and wheat: a meta-analysis.

    PubMed

    Qin, Wei; Hu, Chunsheng; Oenema, Oene

    2015-01-01

    Global crop yields are limited by water and nutrient availability. Soil mulching (with plastic or straw) reduces evaporation, modifies soil temperature and thereby affects crop yields. Reported effects of mulching are sometimes contradictory, likely due to differences in climatic conditions, soil characteristics, crop species, and also water and nitrogen (N) input levels. Here we report on a meta-analysis of the effects of mulching on wheat and maize, using 1310 yield observations from 74 studies conducted in 19 countries. Our results indicate that mulching significantly increased yields, WUE (yield per unit water) and NUE (yield per unit N) by up to 60%, compared with no-mulching. Effects were larger for maize than wheat, and larger for plastic mulching than straw mulching. Interestingly, plastic mulching performed better at relatively low temperature while straw mulching showed the opposite trend. Effects of mulching also tended to decrease with increasing water input. Mulching effects were not related to soil organic matter content. In conclusion, soil mulching can significantly increase maize and wheat yields, WUE and NUE, and thereby may contribute to closing the yield gap between attainable and actual yields, especially in dryland and low nutrient input agriculture. The management of soil mulching requires site-specific knowledge. PMID:26586114

  16. Soil mulching significantly enhances yields and water and nitrogen use efficiencies of maize and wheat: a meta-analysis

    NASA Astrophysics Data System (ADS)

    Qin, Wei; Hu, Chunsheng; Oenema, Oene

    2015-11-01

    Global crop yields are limited by water and nutrient availability. Soil mulching (with plastic or straw) reduces evaporation, modifies soil temperature and thereby affects crop yields. Reported effects of mulching are sometimes contradictory, likely due to differences in climatic conditions, soil characteristics, crop species, and also water and nitrogen (N) input levels. Here we report on a meta-analysis of the effects of mulching on wheat and maize, using 1310 yield observations from 74 studies conducted in 19 countries. Our results indicate that mulching significantly increased yields, WUE (yield per unit water) and NUE (yield per unit N) by up to 60%, compared with no-mulching. Effects were larger for maize than wheat, and larger for plastic mulching than straw mulching. Interestingly, plastic mulching performed better at relatively low temperature while straw mulching showed the opposite trend. Effects of mulching also tended to decrease with increasing water input. Mulching effects were not related to soil organic matter content. In conclusion, soil mulching can significantly increase maize and wheat yields, WUE and NUE, and thereby may contribute to closing the yield gap between attainable and actual yields, especially in dryland and low nutrient input agriculture. The management of soil mulching requires site-specific knowledge.

  17. Soil mulching significantly enhances yields and water and nitrogen use efficiencies of maize and wheat: a meta-analysis

    PubMed Central

    Qin, Wei; Hu, Chunsheng; Oenema, Oene

    2015-01-01

    Global crop yields are limited by water and nutrient availability. Soil mulching (with plastic or straw) reduces evaporation, modifies soil temperature and thereby affects crop yields. Reported effects of mulching are sometimes contradictory, likely due to differences in climatic conditions, soil characteristics, crop species, and also water and nitrogen (N) input levels. Here we report on a meta-analysis of the effects of mulching on wheat and maize, using 1310 yield observations from 74 studies conducted in 19 countries. Our results indicate that mulching significantly increased yields, WUE (yield per unit water) and NUE (yield per unit N) by up to 60%, compared with no-mulching. Effects were larger for maize than wheat, and larger for plastic mulching than straw mulching. Interestingly, plastic mulching performed better at relatively low temperature while straw mulching showed the opposite trend. Effects of mulching also tended to decrease with increasing water input. Mulching effects were not related to soil organic matter content. In conclusion, soil mulching can significantly increase maize and wheat yields, WUE and NUE, and thereby may contribute to closing the yield gap between attainable and actual yields, especially in dryland and low nutrient input agriculture. The management of soil mulching requires site-specific knowledge. PMID:26586114

  18. 76 FR 31379 - Notice of Availability of Environmental Assessment and Finding of No Significant Impact for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-31

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Notice of Availability of Environmental Assessment and Finding of No Significant Impact for License Amendment for ABB, Inc., Windsor, CT AGENCY: U.S. Nuclear Regulatory Commission. ACTION: Notice of availability. FOR FURTHER INFORMATION...

  19. 77 FR 8903 - Environmental Assessment and Finding of No Significant Impact; Carolina Power and Light Company...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-15

    ... COMMISSION Environmental Assessment and Finding of No Significant Impact; Carolina Power and Light Company... CFR) 50.46, ``Acceptance Criteria for Emergency Core Cooling Systems for Light-Water Nuclear Power... Light Company (the licensee), doing business as Progress Energy Carolinas Inc., for operation of...

  20. 77 FR 25131 - Turning Point Solar LLC: Notice of Finding of No Significant Impact

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-27

    ... Rural Utilities Service Turning Point Solar LLC: Notice of Finding of No Significant Impact AGENCY... Assessment (EA) associated with a solar generation project. The EA was prepared in accordance with the... associated with a potential loan or loan guarantee to Turning Point Solar LLC (Turning Point Solar) for...

  1. 76 FR 71619 - Availability of the Final Environmental Assessment (EA) and Finding of No Significant Impact...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-18

    ... Finding of No Significant Impact (FONSI) for Issuing an Experimental Permit to SpaceX for Operation of the... Permit to SpaceX for Operation of the Grasshopper Vehicle at the McGregor Test Site, Texas. The Final EA... Technologies Corporation (SpaceX). Under the Proposed Action, the FAA would issue an experimental permit...

  2. 78 FR 4134 - Availability of the Draft Finding of No Significant Impact and Final Programmatic Environmental...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-18

    ...The Department of the Army announces the availability of the draft Finding of No Significant Impact (FNSI) and final Programmatic Environmental Assessment (PEA) for Army force structure realignments that may occur from Fiscal Years (FYs) 2013-2020. The Army must achieve force reductions as it transitions from major combat operations in Iraq and Afghanistan, while reducing spending without......

  3. 78 FR 46378 - La Crosse Boiling Water Reactor, Environmental Assessment and Finding of No Significant Impact...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-31

    ... COMMISSION La Crosse Boiling Water Reactor, Environmental Assessment and Finding of No Significant Impact... of Title 10 of the Code of Federal Regulations (10 CFR) for the La Crosse Boiling Water Reactor... modifying or adding EP requirements in Section 50.47, Section 50.54, and Appendix E of 10 CFR part 50 (76...

  4. 77 FR 48131 - Draft Finding of No Significant Impact and Programmatic Environmental Assessment for the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-13

    ... Draft Finding of No Significant Impact and the Final Programmatic Environmental Assessment (PEA) for Implementation of the Net Zero program at Army Installations. This PEA evaluates potential direct, indirect, and... private sector to strive toward the Net Zero program's energy, water, and waste reduction goals. The...

  5. 76 FR 19794 - Notice of Availability of Environmental Assessment and Finding of No Significant Impact for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-08

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Notice of Availability of Environmental Assessment and Finding of No Significant Impact for License Amendment for the University of Alaska-Fairbanks, Fairbanks, AK AGENCY: Nuclear Regulatory Commission. ACTION: Notice of availability. FOR...

  6. 75 FR 12581 - Notice of Availability of Environmental Assessment and Finding of No Significant Impact for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-16

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Notice of Availability of Environmental Assessment and Finding of No Significant Impact for Exemption From 10 CFR 30, 40, and 70; Commencement of Construction Requirements; AREVA Enrichment Services, Eagle Rock Enrichment Facility,...

  7. 76 FR 28480 - Environmental Assessment and Finding of No Significant Impact Related to Exemption From Certain...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-17

    ... From the Federal Register Online via the Government Publishing Office ] NUCLEAR REGULATORY COMMISSION ; Docket No. 50-010 Environmental Assessment and Finding of No Significant Impact Related to Exemption From Certain Requirements for the Dresden Nuclear Power Station, Unit No. 1 License DPR-002, Grundy County, IL AGENCY: Nuclear...

  8. 78 FR 28873 - Availability of Final Environmental Assessment and Finding of No Significant Impact for the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-16

    ...This notice announces the availability of a Final Environmental Assessment (Final EA) which examines the reasonably foreseeable environmental impacts and socio-economic impacts of the proposed modification of the historic Bayonne Bridge across the Kill Van Kull between Bayonne, New Jersey and Staten Island, New York. This notice also announces the availability of the Finding of No Significant......

  9. 75 FR 11575 - James A. Fitzpatrick Nuclear Power Plant Environmental Assessment and Finding of No Significant...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-11

    ... COMMISSION James A. Fitzpatrick Nuclear Power Plant Environmental Assessment and Finding of No Significant... Program for Nuclear Power Facilities Operating Prior to January 1, 1979,'' issued to Entergy Nuclear Operations, Inc. (the licensee), for the operation of the James A. FitzPatrick Nuclear Power Plant...

  10. 75 FR 6067 - Notice of Availability of Environmental Assessment and Finding of No Significant Impact for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-05

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Notice of Availability of Environmental Assessment and Finding of No Significant Impact for License Amendment for Revised Groundwater Protection Standards, Western Nuclear, Inc., Jeffrey City, WY AGENCY: Nuclear Regulatory Commission....

  11. 76 FR 74069 - Central Utah Project Completion Act; Finding of No Significant Impact Associated With the...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-30

    ...On September 27, 2011, the Department of the Interior signed a Finding of No Significant Impact which documents the selection of the Proposed Action as presented in the Final Environmental Assessment for the Block Notice 1A Heber Sub-Area Agricultural Water to Municipal & Industrial Water...

  12. Delayed Carcass Deboning Results in Significantly Reduced Cook Yields of Boneless Skinless Chicken Thighs

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Boneless skinless chicken thighs are a new deboned poultry product in the retail market. Three trials were conducted to investigate the effect of postmortem carcass deboning time on the cook yields of boneless skinless chicken thighs as well as boneless skinless chicken breasts. Broiler carcasses ...

  13. Low Carbon Rice Farming Practices in the Mekong Delta Yield Significantly Higher Profits and Lower Greenhouse Gas Emissions

    NASA Astrophysics Data System (ADS)

    Rudek, J.; Van Sanh, N.; Tinh, T. K.; Tin, H. Q.; Thu Ha, T.; Pha, D. N.; Cui, T. Q.; Tin, N. H.; Son, N. N.; Thanh, H. H.; Kien, H. T.; Kritee, K.; Ahuja, R.

    2014-12-01

    The Vietnam Low-Carbon Rice Project (VLCRP) seeks to significantly reduce GHG emissions from rice cultivation, an activity responsible for more than 30% of Vietnam's overall GHG emissions, while improving livelihoods for the rice farmer community by decreasing costs and enhancing yield as well as providing supplemental farmer income through the sale of carbon credits. The Mekong Delta makes up 12% of Vietnam's land area, but produces more than 50% of the country's rice, including more than 90% of the rice for export. Rice cultivation is the main source of income for 80% of farmers in the Mekong Delta. VLCRP was launched in late 2012 in the Mekong Delta in two major rice production provinces, Kien Giang and An Giang. To date, VLCRP has completed 11 crop seasons (in Kien Giang and An Giang combined), training over 400 farmer households in applying VLCRP's package of practices (known as 1 Must - 6 Reductions) and building technical capacity to its key stakeholders and rice farmer community leaders. By adopting the 1 Must- 6 Reductions practices (including reduced seeding density, reduced fertilizer and pesticide application, and alternative wetting and drying water management), rice farmers reduce their input costs while maintaining or improving yields, and decreasing greenhouse gas emissions. The VLCRP package of practices also deliver other environmental and social co-benefits, such as reduced water pollution, improved habitat for fishery resources and reduced health risks for farmers through the reduction of agri-chemicals. VLCRP farmers use significantly less inputs (50% reduction in seed, 30% reduction in fertilizer, 40-50% reduction in water) while improving yields 5-10%, leading to an increase in profit from 10% to as high as 60% per hectare. Preliminary results indicate that the 1 Must- 6 Reductions practices have led to approximately 40-65% reductions in greenhouse gas emissions, equivalent to 4 tons of CO2e/ha/yr in An Giang and 35 tons of CO2e/ha/yr in Kien

  14. Counseling Challenges with Variants of Uncertain Significance and Incidental Findings in Prenatal Genetic Screening and Diagnosis

    PubMed Central

    Westerfield, Lauren; Darilek, Sandra; van den Veyver, Ignatia B.

    2014-01-01

    Prenatal genetic screening and testing provides prospective parents information about the health of their fetus. It is offered to find or address an increased risk for chromosomal abnormalities or other genetic conditions in the fetus or to identify the cause of fetal structural abnormalities detected by prenatal imaging. Genome-wide tests, such as the already widely-used chromosomal microarray analysis and emerging diagnostic whole exome and whole genome sequencing, have improved the ability to detect clinically significant findings, but have also increased the chance of detecting incidental findings and variants of uncertain significance. There is an extensive ongoing discussion about optimal strategies for diagnostic laboratories to report such findings and for providers to communicate them with patients. While consensus opinions and guidelines are beginning to appear, they often exclude the prenatal setting, due to its unique set of challenging considerations. These include more limited knowledge of the impact of genetic variants when prospectively detected in an ongoing pregnancy, the absence or limitations of detecting clinically recognizable phenotypes at the time of testing and the different decision-making processes that will ensue from testing. In this review, we examine these challenges within the medical ethical framework unique to prenatal care. PMID:26237491

  15. FOCUSED R&D FOR ELECTROCHROMIC SMART WINDOWS: SIGNIFICANT PERFORMANCE AND YIELD ENHANCEMENTS

    SciTech Connect

    Marcus Milling

    2004-09-23

    Developments made under this program will play a key role in underpinning the technology for producing EC devices. It is anticipated that the work begun during this period will continue to improve materials properties, and drive yields up and costs down, increase durability and make manufacture simpler and more cost effective. It is hoped that this will contribute to a successful and profitable industry, which will help reduce energy consumption and improve comfort for building occupants worldwide. The first major task involved improvements to the materials used in the process. The improvements made as a result of the work done during this project have contributed to the enhanced performance, including dynamic range, uniformity and electrical characteristics. Another major objective of the project was to develop technology to improve yield, reduce cost, and facilitate manufacturing of EC products. Improvements directly attributable to the work carried out as part of this project and seen in the overall EC device performance, have been accompanied by an improvement in the repeatability and consistency of the production process. Innovative test facilities for characterizing devices in a timely and well-defined manner have been developed. The equipment has been designed in such a way as to make scaling-up to accommodate higher throughput necessary for manufacturing relatively straightforward. Finally, the third major goal was to assure the durability of the EC product, both by developments aimed at improving the product performance, as well as development of novel procedures to test the durability of this new product. Both aspects have been demonstrated, both by carrying out a number of different durability tests, both in-house and by independent third-party testers, and also developing several novel durability tests.

  16. Finding of No Significant Impact, proposed remediation of the Maybell Uranium Mill Processing Site, Maybell, Colorado

    SciTech Connect

    Not Available

    1995-12-31

    The U.S. Department of Energy (DOE) has prepared an environmental assessment (EA) (DOE/EA-0347) on the proposed surface remediation of the Maybell uranium mill processing site in Moffat County, Colorado. The mill site contains radioactively contaminated materials from processing uranium ore that would be stabilized in place at the existing tailings pile location. Based on the analysis in the EA, DOE has determined that the proposed action does not constitute a major federal action significantly affecting the quality of the human environment within the meaning of the National Environmental Policy Act (NEPA) of 1969, Public Law 91-190 (42 U.S.C. {section}4321 et seq.), as amended. Therefore, preparation of an environmental impact statement is not required and DOE is issuing this Finding of No Significant Impact (FONSI).

  17. Environmental Assessment and Finding of No Significant Impact: Kalina Geothermal Demonstration Project Steamboat Springs, Nevada

    SciTech Connect

    N /A

    1999-02-22

    The Department of Energy (DOE) has prepared an Environmental Assessment (EA) to provide the DOE and other public agency decision makers with the environmental documentation required to take informed discretionary action on the proposed Kalina Geothermal Demonstration project. The EA assesses the potential environmental impacts and cumulative impacts, possible ways to minimize effects associated with partial funding of the proposed project, and discusses alternatives to DOE actions. The DOE will use this EA as a basis for their decision to provide financial assistance to Exergy, Inc. (Exergy), the project applicant. Based on the analysis in the EA, DOE has determined that the proposed action is not a major Federal action significantly affecting the quality of the human or physical environment, within the meaning of the National Environmental Policy Act (NEPA) of 1969. Therefore, the preparation of an environmental impact statement is not required and DOE is issuing this Finding of No Significant Impact (FONSI).

  18. Mid-Columbia Coho Reintroduction Feasibility Project : Final Environmental Assessment and Finding of No Significant Impact.

    SciTech Connect

    United States. Bonneville Power Administration; Confederated Tribes and Bands of the Yakama Nation; Washington State Department of Fish and Wildlife

    1999-04-01

    Bonneville Power Administration (BPA) is proposing to fund research for 2 to 3 years on the feasibility of reintroducing coho salmon into mid-Columbia River basin tributaries. The research would take place in the Methow and Wenatchee river basins in Chelan and Okanogan Counties, Washington. BPA has prepared an Environmental Assessment (EA) (DOE/EA-1282) evaluating the proposed project. Based on the analysis in the EA, BPA has determined that the proposed action is not a major Federal action significantly affecting the quality of the human environment, within the meaning of the National Environmental Policy Act (NEPA) of 1969. Therefore, the preparation of an Environmental Impact Statement (EIS) is not required, and BPA is issuing this Finding of No Significant Impact.

  19. Tucannon River Spring Chinook Captive Broodstock Program Final Environmental Assessment and Finding of No Significant Impact

    SciTech Connect

    N /A

    2000-05-24

    Bonneville Power Administration (BPA) is proposing to fund the Tucannon River Spring Chinook Captive Broodstock Program, a small-scale production initiative designed to increase numbers of a weak but potentially recoverable population of spring chinook salmon in the Tucannon River in the State of Washington. BPA has prepared an Environmental Assessment (EA) (DOE/EA-l326) evaluating the proposed project. Based on the analysis in the EA, BPA has determined that the proposed action is not a major Federal action significantly affecting the quality of the human environment, within the meaning of the National Environmental Policy Act (NEPA) of 1969. Therefore, the preparation of an Environmental Impact Statement (EIS) is not required, and BPA is issuing this Finding of No Significant Impact (FONSI).

  20. The relationship between specific event sediment yields and runoff depth and its significance

    NASA Astrophysics Data System (ADS)

    Gao, P.; Nearing, M.; Hicks, M.; Commons, M.

    2012-12-01

    Although the dynamics of suspended sediment transport are complex, they may become less complex and hence easier to quantify as the time scale increases from instantaneous to event-lumped transport. To test this hypothesis, we collected suspended sediment data from watersheds with contrasting transport behavior (supply-limited and transport-limited), together with those reported in Loess areas of China. Supply-limited watersheds (type I) included four Australia watersheds with various land use and land cover (LULC) conditions and a central New York watershed. Transport-limited watersheds (type II) contained twelve watersheds from Walnut Gulch, Arizona and an Italy watershed. Type III watersheds involved fourteen watersheds in Loess area of upstream Yellow River, China. They are different from the others in that they have hyperconcentrated flows most of time during events due to the finer grain size of loess. We calculated specific event sediment yield (SSYe, t/km2) and runoff depth (h, mm) of various rainfall events in each watershed, and statistically established a proportional relationship, SSYe = Ch where C is a constant for a given watershed, which is equivalent to the discharge-weighted event mean sediment concentration. The coefficient of determination ranges from 0.64 to 0.99, with the median of 0.95 indicating that the proportional model generally holds. Furthermore, values of C showed distinct ranges for the three types of watersheds: 0.32 - 1.93 for type I watersheds, 7.17-34.39 for type II watersheds, and 680-861 for type III watersheds. These values correctly reflect the different nature of sediment transport in three types of watersheds. We further found that C begins to decrease at different threshold values of watershed area for types I and II watersheds, whereas C remains constant for type III watersheds. These results suggest that a simple proportional model may be used to describe event-lumped behavior of suspended sediment transport.

  1. Student-led exercise sessions yield significant fitness gains for Alzheimer's patients.

    PubMed

    Arkin, Sharon M

    2003-01-01

    At a time when they are losing skills in virtually all arenas of life, persons with Alzheimer's disease can experience significant, esteem-building achievements in physical fitness and mood through supervised participation in an exercise program. The effects of physical exercise plus cognitive and social stimulation on persons with early stage Alzheimer's disease were assessed in a longitudinal study. Twenty-four such individuals, aged 54 to 88 at program entry, participated in 16 to 20 exercise sessions and 10 community activity sessions per semester for two to eight semesters. Half of the weekly exercise sessions included memory and language stimulation activities. Students, supplemented by family caregivers, supervised the sessions. Exercise sessions consisted of flexibility, balance, aerobic, and weight resistance activities. Preparticipation and semiannual post-testing of aerobic fitness and duration and upper and lower body strength was done. Highly significant fitness gains (p < .001) were achieved in the six-minute walk test, upper and lower body strength, and duration of aerobic exercise. Five participants, aged 86 to 91, completed six to eight semesters and were doing 27 to 45 minutes of aerobics per session at program's end. Five participants scored within the normal range for age-matched healthy active adults on the six-minute walk test at baseline. Nine others achieved and three exceeded the normal range during treatment. Cognitive decline was slowed and mood improved. First-year cognitive outcomes have been published elsewhere. An article reporting final cognitive outcomes is in preparation; Outcome data is summarized on the project website: www.u.arizona.edu/ ~sarkin/elderrehab.html. The benefits of physical exercise can be made available at nominal cost to Alzheimer's patients and other elderly persons by using students to provide transportation, supervision, and the motivational support that is key to exercise adherence. Further research is needed

  2. Cochlear implantation with hearing preservation yields significant benefit for speech recognition in complex listening environments

    PubMed Central

    Gifford, René H.; Dorman, Michael F.; Skarzynski, Henryk; Lorens, Artur; Polak, Marek; Driscoll, Colin L. W.; Roland, Peter; Buchman, Craig A.

    2012-01-01

    Objective The aim of this study was to assess the benefit of having preserved acoustic hearing in the implanted ear for speech recognition in complex listening environments. Design The current study included a within subjects, repeated-measures design including 21 English speaking and 17 Polish speaking cochlear implant recipients with preserved acoustic hearing in the implanted ear. The patients were implanted with electrodes that varied in insertion depth from 10 to 31 mm. Mean preoperative low-frequency thresholds (average of 125, 250 and 500 Hz) in the implanted ear were 39.3 and 23.4 dB HL for the English- and Polish-speaking participants, respectively. In one condition, speech perception was assessed in an 8-loudspeaker environment in which the speech signals were presented from one loudspeaker and restaurant noise was presented from all loudspeakers. In another condition, the signals were presented in a simulation of a reverberant environment with a reverberation time of 0.6 sec. The response measures included speech reception thresholds (SRTs) and percent correct sentence understanding for two test conditions: cochlear implant (CI) plus low-frequency hearing in the contralateral ear (bimodal condition) and CI plus low-frequency hearing in both ears (best aided condition). A subset of 6 English-speaking listeners were also assessed on measures of interaural time difference (ITD) thresholds for a 250-Hz signal. Results Small, but significant, improvements in performance (1.7 – 2.1 dB and 6 – 10 percentage points) were found for the best-aided condition vs. the bimodal condition. Postoperative thresholds in the implanted ear were correlated with the degree of EAS benefit for speech recognition in diffuse noise. There was no reliable relationship among measures of audiometric threshold in the implanted ear nor elevation in threshold following surgery and improvement in speech understanding in reverberation. There was a significant correlation between ITD

  3. Focused R&D For Electrochromic Smart Windowsa: Significant Performance and Yield Enhancements

    SciTech Connect

    Mark Burdis; Neil Sbar

    2003-01-31

    There is a need to improve the energy efficiency of building envelopes as they are the primary factor governing the heating, cooling, lighting and ventilation requirements of buildings--influencing 53% of building energy use. In particular, windows contribute significantly to the overall energy performance of building envelopes, thus there is a need to develop advanced energy efficient window and glazing systems. Electrochromic (EC) windows represent the next generation of advanced glazing technology that will (1) reduce the energy consumed in buildings, (2) improve the overall comfort of the building occupants, and (3) improve the thermal performance of the building envelope. ''Switchable'' EC windows provide, on demand, dynamic control of visible light, solar heat gain, and glare without blocking the view. As exterior light levels change, the window's performance can be electronically adjusted to suit conditions. A schematic illustrating how SageGlass{reg_sign} electrochromic windows work is shown in Figure I.1. SageGlass{reg_sign} EC glazings offer the potential to save cooling and lighting costs, with the added benefit of improving thermal and visual comfort. Control over solar heat gain will also result in the use of smaller HVAC equipment. If a step change in the energy efficiency and performance of buildings is to be achieved, there is a clear need to bring EC technology to the marketplace. This project addresses accelerating the widespread introduction of EC windows in buildings and thus maximizing total energy savings in the U.S. and worldwide. We report on R&D activities to improve the optical performance needed to broadly penetrate the full range of architectural markets. Also, processing enhancements have been implemented to reduce manufacturing costs. Finally, tests are being conducted to demonstrate the durability of the EC device and the dual pane insulating glass unit (IGU) to be at least equal to that of conventional windows.

  4. Environmental Assessment and Finding of No Significant Impact: Sunrise II Water Supply Line

    SciTech Connect

    N /A

    2002-10-09

    Sunrise Power Company, LLC (Sunrise), has planned the modification of an existing power plant project to increase its generation capacity by 265 megawatts by 2003. The initial Sunrise facility was constructed in accordance with a license issued by the California Energy Commission (CEC) on December 6, 2000 and brought 320 MW of much needed power to commercial operation in June 2001. The Governor of the State of California issued recent Executive Orders to provide for emergency permit streamlining of projects that can help alleviate the current California energy crisis. Specifically, Executive Order D-25-01 directed the CEC to expedite processing amendments such as the Sunrise II modification that would increase generating capacity from 320 MW to 585 MW by summer 2003. As part of the modification, an approximately 15.3 mile water line will be installed. Additionally, improvements to West Kern Water District's (WKWD) Pumping Station ''B'', located on DOE land, will occur. Sunrise has requested a right-of-way grant for the construction of the water supply line on U.S. Bureau of Land Management (BLM) and DOE lands. Pursuant to the requirements of the National Environmental Policy Act of 1969 (NEPA), as amended, the potential impacts of the proposed action were analyzed in an Environmental Assessment (EA-1434) with the BLM acting as lead agency. Based on the analysis of the potential environmental impacts contained in the Environmental Assessment (EA), BLM has determined that significant impacts are not expected and an environmental impact statement is not required. The DOE, acting as a cooperating agency, has adopted the BLM's EA and is consequently issuing this Finding of No Significant Impact.

  5. (Bradfield Electric and Alaska Power Authority Presidential permit): Finding of no significant impact (FONSI)

    SciTech Connect

    Not Available

    1988-01-01

    The Economic Regulatory Administration (ERA) of the Department of Energy (DOE) is considering an application by Bradfield Electric, Inc. (Bradfield), and the Alaska Power Authority (APA) for a Presidential permit to construct, operate, maintain and connect a 69-kilovolt (kV) transmission line which would extend from the APA's Tyee Lake Hydroelectric Power Project located near Wrangell, Alaska, to a point on the US-Canadian international border just east of the South Fork Craig River. The DOE has reviewed an environmental assessment (EA) prepared by the US Forest Service (USFS) in connection with its issuance of a special use permit to construct the proposed line through the Tongass National Forest. Based on this EA, the USFS issued a decision notice and a finding of no significant impact (FONSI) for the proposed project on May 9, 1988. The DOE is adopting this EA as DOE/EA-0375 in partial satisfaction of its responsibilities under the National Environmental Policy Act of 1969 (NEPA) regarding the issuance of a Presidential permit.

  6. Prognostic significance of electrocardiographic findings in angina at rest. Therapeutic implications.

    PubMed Central

    Demoulin, J C; Bertholet, M; Chevigne, M; Legrand, V; Renier, J; Soumagne, D; Soyeur, D; Limet, R; Kulbertus, H

    1981-01-01

    Ninety-five patients with angina at rest were observed in the coronary care unit. Eighty-one per cent presented concomitantly or had previously presented some other manifestations of coronary artery disease. These patients were divided into two subgroups. In subgroup 1 (40 patients), episodes of non-exertional angina were associated with a pattern of hyperacute subepicardial injury and, frequently, with ventricular arrhythmias. In subgroup 2 (55 patients), the episodes of angina at rest were attended by horizontal ST depression, isolated T wave inversion, or trivial ST-T changes. Coronary angiographic findings were similar in both subgroups. Symptoms regressed in only 9% of patients in subgroup 1 while they were receiving beta-receptor antagonists, whereas amiodarone alone or amiodarone with nifedipine was successful in 58%. Of these patients, 25% developed a myocardial infarction shortly after admission. In subgroup 2 patients, beta-blockers were successful in 61%. Amiodarone isolated or associated with nifedipine was successful in 55% of the patients in whom it was tried. Only 5% of patients in this subgroup developed a myocardial infarction during their hospital stay. It is concluded that: (1) observation of the electrocardiogram during spontaneous angina in patients with known atherosclerotic coronary heart disease may be of prognostic significance and may influence therapeutic decision. (2) Amiodarone by virtue of its anginal and antiarrhythmic properties may be particularly useful in the treatment of non-exertional angina. PMID:6117297

  7. Seduction of Finding Universality in Sputtering Yields Due to Cluster Bombardment of Solids.

    PubMed

    Paruch, Robert J; Postawa, Zbigniew; Garrison, Barbara J

    2015-09-15

    Universal descriptions are appealing because they simplify the description of different (but similar) physical systems, allow the determination of general properties, and have practical applications. Recently, the concept of universality has been applied to the dependence of the sputtering (ejection) yield due to energetic cluster bombardment versus the energy of the incident cluster. It was observed that the spread in data points can be reduced if the yield Y and initial projectile cluster kinetic energy E are expressed in quantities scaled by the number of cluster atoms n, that is, Y/n versus E/n. The convergence of the data points is, however, not perfect, especially when the results for molecular and atomic solids are compared. In addition, the physics underlying the apparent universal dependence in not fully understood. For the study presented in this Account, we performed molecular dynamics simulations of Arn cluster bombardment of molecular (benzene, octane, and β-carotene) and atomic (Ag) solids in order to address the physical basis of the apparent universal dependence. We have demonstrated that the convergence of the data points between molecular and atomic solids can be improved if the binding energy of the solid U0 is included and the dependence is presented as Y/(E/U0) versus (E/U0)/n. As a material property, the quantity U0 is defined per the basic unit of material, which is an atom for atomic solids and a molecule for molecular solids. Analogously, the quantity Y is given in atoms and molecules, respectively. The simulations show that, for almost 3 orders of magnitude variation of (E/U0)/n, there are obvious similarities in the ejection mechanisms between the molecular and atomic solids, thus supporting the concept of universality. For large (E/U0)/n values, the mechanism of ejection is the fluid flow from a cone-shaped volume. This regime of (E/U0)/n is generally accessed experimentally by clusters with hundreds of atoms and results in the largest

  8. 76 FR 60115 - Notice of Availability of the Finding of No Significant Impact for the Metropolitan Branch Trail

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-28

    ... Notice of Availability of the Finding of No Significant Impact for the Metropolitan Branch Trail AGENCIES...; in cooperation with the National Park Service. ACTION: Notice of availability of the Finding of No... with the National Park Service (NPS), announce the availability of the Finding of No Significant...

  9. Yield of intensified tuberculosis case-finding activities using Xpert® MTB/RIF among risk groups in Nepal

    PubMed Central

    Baral, S.; Shrestha, P.; Puri, M.; Kandel, S.; Lamichanne, B.; Elsey, H.; Brouwer, M.; Goel, S.; Chinnakali, P.

    2016-01-01

    Setting: Twenty-two districts of Nepal, where intensified case-finding (ICF) activities for tuberculosis (TB) were implemented among risk groups under the TB REACH initiative in collaboration with the National TB Programme from July 2013 to November 2015. Objectives: To assess the yield of TB screening using an algorithm with smear microscopy followed by Xpert® MTB/RIF. Design: A descriptive study using routinely collected data. Results: Of 145 679 individuals screened, 28 574 (19.6%) had presumptive TB; 1239 (4.3%) of these were diagnosed with TB and 1195 (96%) were initiated on anti-tuberculosis treatment. The yield of screening was highest among people living with the human immunodeficiency virus (PLHIV) (6.1%), followed by household contacts (3.5%) and urban slum dwellers (0.5%). Among other risk groups, such as prisoners, factory workers, refugees and individuals with diabetes, the yield was less than 0.5%. The number needed to screen to diagnose an active TB case was 17 for PLHIV, 29 for household contacts and 197 for urban slum dwellers. Of 11 525 patients from ICF and the routine programme, 112 (1%) were diagnosed with multidrug-resistant TB. Conclusion: There was a substantial yield of TB cases among risk groups such as PLHIV and household contacts. Although the yield in urban slum dwellers was found to be moderate, some intervention should nonetheless be targeted because of the large population and poor access to care in this group. PMID:27358808

  10. Constitutive overexpression of the TaNF-YB4 gene in transgenic wheat significantly improves grain yield.

    PubMed

    Yadav, Dinesh; Shavrukov, Yuri; Bazanova, Natalia; Chirkova, Larissa; Borisjuk, Nikolai; Kovalchuk, Nataliya; Ismagul, Ainur; Parent, Boris; Langridge, Peter; Hrmova, Maria; Lopato, Sergiy

    2015-11-01

    Heterotrimeric nuclear factors Y (NF-Ys) are involved in regulation of various vital functions in all eukaryotic organisms. Although a number of NF-Y subunits have been characterized in model plants, only a few have been functionally evaluated in crops. In this work, a number of genes encoding NF-YB and NF-YC subunits were isolated from drought-tolerant wheat (Triticum aestivum L. cv. RAC875), and the impact of the overexpression of TaNF-YB4 in the Australian wheat cultivar Gladius was investigated. TaNF-YB4 was isolated as a result of two consecutive yeast two-hybrid (Y2H) screens, where ZmNF-YB2a was used as a starting bait. A new NF-YC subunit, designated TaNF-YC15, was isolated in the first Y2H screen and used as bait in a second screen, which identified two wheat NF-YB subunits, TaNF-YB2 and TaNF-YB4. Three-dimensional modelling of a TaNF-YB2/TaNF-YC15 dimer revealed structural determinants that may underlie interaction selectivity. The TaNF-YB4 gene was placed under the control of the strong constitutive polyubiquitin promoter from maize and introduced into wheat by biolistic bombardment. The growth and yield components of several independent transgenic lines with up-regulated levels of TaNF-YB4 were evaluated under well-watered conditions (T1-T3 generations) and under mild drought (T2 generation). Analysis of T2 plants was performed in large deep containers in conditions close to field trials. Under optimal watering conditions, transgenic wheat plants produced significantly more spikes but other yield components did not change. This resulted in a 20-30% increased grain yield compared with untransformed control plants. Under water-limited conditions transgenic lines maintained parity in yield performance. PMID:26220082

  11. Constitutive overexpression of the TaNF-YB4 gene in transgenic wheat significantly improves grain yield

    PubMed Central

    Yadav, Dinesh; Shavrukov, Yuri; Bazanova, Natalia; Chirkova, Larissa; Borisjuk, Nikolai; Kovalchuk, Nataliya; Ismagul, Ainur; Parent, Boris; Langridge, Peter; Hrmova, Maria; Lopato, Sergiy

    2015-01-01

    Heterotrimeric nuclear factors Y (NF-Ys) are involved in regulation of various vital functions in all eukaryotic organisms. Although a number of NF-Y subunits have been characterized in model plants, only a few have been functionally evaluated in crops. In this work, a number of genes encoding NF-YB and NF-YC subunits were isolated from drought-tolerant wheat (Triticum aestivum L. cv. RAC875), and the impact of the overexpression of TaNF-YB4 in the Australian wheat cultivar Gladius was investigated. TaNF-YB4 was isolated as a result of two consecutive yeast two-hybrid (Y2H) screens, where ZmNF-YB2a was used as a starting bait. A new NF-YC subunit, designated TaNF-YC15, was isolated in the first Y2H screen and used as bait in a second screen, which identified two wheat NF-YB subunits, TaNF-YB2 and TaNF-YB4. Three-dimensional modelling of a TaNF-YB2/TaNF-YC15 dimer revealed structural determinants that may underlie interaction selectivity. The TaNF-YB4 gene was placed under the control of the strong constitutive polyubiquitin promoter from maize and introduced into wheat by biolistic bombardment. The growth and yield components of several independent transgenic lines with up-regulated levels of TaNF-YB4 were evaluated under well-watered conditions (T1–T3 generations) and under mild drought (T2 generation). Analysis of T2 plants was performed in large deep containers in conditions close to field trials. Under optimal watering conditions, transgenic wheat plants produced significantly more spikes but other yield components did not change. This resulted in a 20–30% increased grain yield compared with untransformed control plants. Under water-limited conditions transgenic lines maintained parity in yield performance. PMID:26220082

  12. 75 FR 34151 - Availability: Final Comprehensive Conservation Plan and Finding of No Significant Impact; Modoc...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-16

    ... managers with a 15-year plan for achieving refuge purposes and contributing toward the mission of the... press releases, updates to constituents, and a Federal Register notice (74 FR 28271, June 15, 2009). The... Fish and Wildlife Service Availability: Final Comprehensive Conservation Plan and Finding of...

  13. 77 FR 49457 - Availability of the Final Environmental Assessment and Finding of No Significant Impact for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-16

    ..., 1981, (46 FR 44083); the United States Section hereby gives notice that the Final Environmental... review of the draft EA indicates that there will not be a significant impact on the quality of the human... regional in scope. 2. The proposed action will not significantly affect public health or safety....

  14. 78 FR 7850 - Notice of Availability of Finding of No Significant Impact for the Proposed NOVA Chemicals Inc...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-04

    ... of Availability of Finding of No Significant Impact for the Proposed NOVA Chemicals Inc. Line 20... of the Department of State's Finding of No Significant Impact on the proposed NOVA Chemicals Inc... other non-gaseous fuels to or from a foreign country. NOVA Chemicals Inc. (NOVA) has applied to...

  15. 10 CFR 51.35 - Requirement to publish finding of no significant impact; limitation on Commission action.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Requirement to publish finding of no significant impact... Requirement to publish finding of no significant impact; limitation on Commission action. (a) Whenever the... published in the Federal Register as provided in § 51.119. (b) Except as provided in § 51.13, the...

  16. Writing the Discussion Section: Describing the Significance of the Study Findings.

    PubMed

    Bavdekar, Sandeep B

    2015-11-01

    The Discussion section is an important part of the research manuscript that allows the authors to showcase the study. It is used to interpret the results for readers, describe the virtues and limitations of the study, discuss the theoretical and practical implications of the research work done and provide important "take home" message. The Discussion section of a paper intends to convey what the findings of the study mean and hence has been likened to the closing arguments put forth by counselors in a court case. It is the last chance for an author to "sell" his paper. The discussion section should be written in a focused manner getting straight to answering the research question raised in the introduction section. Such a direct approach is likely to make a lasting impression on the minds of the readers. The discussion section is considered harder to define as compared to the other sections of the research paper. While other sections require orderly and simple logical writing; composing discussion section requires logical thinking, reflection and critical appraisal. A well-written discussion section includes a statement of important results, reference to previously published relevant literature, comparison of study results with previously reported findings, explanation of results, elucidations of strengths and weaknesses of the study, interpretation of the whole evidence, description of impact of the study and recommendations for the future course of action. PMID:27608782

  17. 75 FR 65294 - Southern Maryland Electric Cooperative: Notice of Finding of No Significant Impact

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-22

    ... at: http://www.usda.gov/rus/water/ees/ea.htm . SUPPLEMENTARY INFORMATION: SMECO proposes to construct... Pardoe Road, west of Maryland Highways 2 and 4 near the Calvert Cliffs tap. Approximately 6 to 10 acres..., RUS has concluded that the proposal would have no significant impacts to water quality, wetlands,...

  18. A Visitor's Guide to Effect Sizes--Statistical Significance versus Practical (Clinical) Importance of Research Findings

    ERIC Educational Resources Information Center

    Hojat, Mohammadreza; Xu, Gang

    2004-01-01

    Effect Sizes (ES) are an increasingly important index used to quantify the degree of practical significance of study results. This paper gives an introduction to the computation and interpretation of effect sizes from the perspective of the consumer of the research literature. The key points made are: (1) "ES" is a useful indicator of the…

  19. 75 FR 69138 - Environmental Assessment and Finding of No Significant Impact Related to Exemption of Material...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-10

    ... hazardous waste containing low-activity radioactive debris, at the US Ecology Idaho (USEI) Resource... authorization for the disposal of waste from the HBPP at the US Ecology Idaho (USEI) facility in accordance with... and there is no significant increase in occupational or public radiation exposures. With regard...

  20. 77 FR 76050 - Draft Environmental Assessment and Preliminary Finding of No Significant Impact Concerning a...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-26

    ... Significant Impact Concerning a Genetically Engineered Atlantic Salmon; Availability AGENCY: Food and Drug... a new animal drug application (NADA) concerning a genetically engineered (GE) Atlantic salmon. Also... EA prepared by FDA in support of an NADA associated with AQUADVANTAGE Salmon, a GE Atlantic...

  1. Finding the Intersection of the Learning Organization and Learning Transfer: The Significance of Leadership

    ERIC Educational Resources Information Center

    Kim, Jun Hee; Callahan, Jamie L.

    2013-01-01

    Purpose: This article aims to develop a conceptual framework delineating the key dimension of the learning organization which significantly influences learning transfer. Design/methodology/approach: The conceptual framework was developed by analyzing previous studies and synthesizing the results associated with the following four relationships:…

  2. [Histologic finding of fracture healing using external fixation and its clinical significance].

    PubMed

    Stürmer, K M

    1984-06-01

    The histology of bone healing under external fixation of fractures is studied in 2 human bone specimen and in the sheep's tibia. Primary bone healing occurs under absolute stable fixation. The regular course shows secundary bone healing by endosteal and periosteal callus formation, caused by motion in the fracture gap. Nonunion results, if motion is not big enough to induce callus formation and if motion is too big to allow primary bone healing. So one of the main problems in external fixation of fractures is to find out the adequate dose of stability and motion in the fracture gap. External fixation does not disturb the vascular supply of bone. Intramedullary vessels, that are cut during the osteotomy of the sheep's tibia, are perfectly regenerated 4-5 weeks later. In the surroundings of the Schanz' screws, cortical remodelling is the biomechanical response of bone to strees, which is generated by external fixation. This cortical remodelling can reduce compression, originally applied to the bone. The indication and the timing for a change to internal fixation is discussed. PMID:6474602

  3. Billy Shaw Dam and Reservoir : Environmental Assessment and Finding of No Significant Impacts.

    SciTech Connect

    United States. Bonneville Power Administration; Shoshone-Paiute Tribes of the Duck Valley Reservation, Nevada.

    1997-03-01

    This notice announces BPA`s decision to fund the construction, operation, and maintenance of the Billy Shaw Dam and Reservoir on the Duck Valley Reservation. This project is part of a continuing effort to address system-wide fish and wildlife losses caused by the development of the hydropower system in the Columbia River Basin. BPA has prepared an Environmental Assessment (EA) evaluating the potential environmental impacts of the proposed project. Based on the analysis in the EA, BPA has determined that the Proposed Action is not a major Federal action significantly affecting the quality of the human environment, within the meaning of the National Environmental Policy Act (NEPA) of 1969. Therefore, the preparation of an Environmental Impact Statement (EIS) is not required and BPA is issuing this FONSI.

  4. Functional significance of predischarge exercise thallium-201 findings following intravenous streptokinase therapy during acute myocardial infarction

    SciTech Connect

    Touchstone, D.A.; Beller, G.A.; Nygaard, T.W.; Watson, D.D.; Tedesco, C.; Kaul, S.

    1988-12-01

    The purpose of this study was to determine which predischarge exercise thallium-201 imaging pattern(s) best correlate with myocardial salvage following intravenous streptokinase therapy (IVSK). Myocardial salvage was defined as improvement in regional left ventricular function determined by two-dimensional echocardiography between the time of admission and time of discharge in 21 prospectively studied patients receiving IVSK within 4 hours of chest pain. All patients had coronary angiography 2 hours following IVSK. Whereas 16 of the 21 patients (76%) had patent infarct-related vessels, only seven (33%) showed significant improvement in regional function at hospital discharge. Eleven patients demonstrated persistent defects (PD), and five each showed delayed and reverse redistribution. Patients with both delayed and reverse redistribution demonstrated significant improvement in regional left ventricular function score, while those with PD did not (+3.9 +/- 3.3 versus -0.5 +/- 2.9, p = 0.004). All other clinical, exercise, electrocardiographic, scintigraphic, and angiographic variables were similar between all patients, with the exception of the interval between chest pain and the institution of IVSK, which was longer in patients with reverse compared to delayed redistribution (3.5 +/- 0.4 versus 2.2 +/- 0.4 hours, p = 0.001). It is concluded that both delayed and reverse redistribution seen on predischarge exercise thallium-201 imaging are associated with myocardial salvage, defined as serial improvement in regional systolic function. Despite a high infarct vessel patency rate in patients with acute myocardial infarction receiving IVSK within 4 hours of onset of symptoms, only one third demonstrated improvement in regional function that was associated with either delayed or reverse redistribution seen on predischarge exercise thallium-201 imaging.

  5. Can I be sued for that? Liability risk and the disclosure of clinically significant genetic research findings

    PubMed Central

    McGuire, Amy L.; Knoppers, Bartha Maria; Zawati, Ma’n H.; Clayton, Ellen Wright

    2014-01-01

    Genomic researchers increasingly are faced with difficult decisions about whether, under what circumstances, and how to return research results and significant incidental findings to study participants. Many have argued that there is an ethical—maybe even a legal—obligation to disclose significant findings under some circumstances. At the international level, over the last decade there has begun to emerge a clear legal obligation to return significant findings discovered during the course of research. However, there is no explicit legal duty to disclose in the United States. This creates legal uncertainty that may lead to unmanaged variation in practice and poor quality care. This article discusses liability risks associated with the disclosure of significant research findings for investigators in the United States. PMID:24676095

  6. Surface water drainage system. Environmental assessment and finding of no significant impact

    SciTech Connect

    1996-05-01

    This Environmental Assessment (EA) is written pursuant to the National Environmental Policy Act (NEPA). The document identifies and evaluates the action proposed to correct deficiencies in, and then to maintain, the surface water drainage system serving the Department of Energy`s Rocky Flats Environmental Technology Site (Site), located north of Golden, Colorado. Many of the activities proposed would not normally be subject to this level of NEPA documentation. However, in many cases, maintenance of the system has been deferred to the point that wetlands vegetation has become established in some ditches and culverts, creating wetlands. The proposed activities would damage or remove some of these wetlands in order to return the drainage system to the point that it would be able to fully serve its intended function - stormwater control. The Department of Energy (DOE) regulations require that activities affecting environmentally sensitive areas like wetlands be the subject of an EA. Most portions of the surface water drainage system are presently inadequate to convey the runoff from a 100-year storm event. As a result, such an event would cause flooding across much of the Site and possibly threaten the integrity of the dams at the terminal ponds. Severe flooding would not only cause damage to facilities and equipment, but could also facilitate the transport of contaminants from individual hazardous substance sites (IHSSs). Uncontrolled flow through the A- and B-series ponds could cause contaminated sediments to become suspended and carried downstream. Additionally, high velocity flood flows significantly increase erosion losses.

  7. Scientists Find X Rays from Stellar Winds That May Play Significant Role in Galactic Evolution

    NASA Astrophysics Data System (ADS)

    2001-09-01

    Colorful star-forming regions that have captivated stargazers since the advent of the telescope 400 years ago contain gas thousands of times more energetic than previously recognized, powered by colliding stellar winds. This multimillion-degree gas radiated as X rays is one of the long-sought sources of energy and elements in the Milky Way galaxy's interstellar medium. A team led by Leisa Townsley, a senior research associate in astronomy and astrophysics at Penn State University, uncovered this wind phenomenon in the Rosette Nebula, a stellar nursery. With the Chandra X-ray Observatory, the team found that the most massive stars in the nebula produce winds that slam into each other, create violent shocks, and infuse the region with 6-million-degree gas. The findings are presented in Washington, D.C., today at a conference entitled "Two Years of Science with Chandra." "A ghostly glow of diffuse X-ray emission pervades the Rosette Nebula and perhaps many other similar star-forming regions throughout the Galaxy," said Townsley. "We now have a new view of the engine lighting the beautiful Rosette Nebula and new evidence for how the interstellar medium may be energized." Townsley and her colleagues created a striking X-ray panorama of the Rosette Molecular Cloud from four images with Chandra's Advanced CCD Imaging Spectrometer. This is a swath of the sky nearly 100 light years across sprayed with hundreds of X-ray-emitting young stars. In one corner of the Rosette Molecular Cloud lies the Rosette Nebula, called an "H II region" because the hydrogen gas there has been stripped of its electrons due to the strong ultraviolet radiation from its young stars. This region, about 5,000 light years away in the constellation Monoceros, the Unicorn, has long been a favorite among amateur astronomers. The wispy, colorful display is visible with small telescopes. The Chandra survey reveals, for the first time, 6-million-degree gas at the center of the Rosette Nebula, occupying a

  8. Findings

    MedlinePlus

    ... Issue All Issues Explore Findings by Topic Cell Biology Cellular Structures, Functions, Processes, Imaging, Stress Response Chemistry ... Glycobiology, Synthesis, Natural Products, Chemical Reactions Computers in Biology Bioinformatics, Modeling, Systems Biology, Data Visualization Diseases Cancer, ...

  9. 76 FR 15935 - Availability of an Environmental Assessment and Finding of No Significant Impact for a Biological...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-22

    ... 19, 2011, we published in the Federal Register (76 FR 3076-3077, Docket No. APHIS-2010-0115) a notice... Significant Impact for a Biological Control Agent for Air Potato AGENCY: Animal and Plant Health Inspection... relative to the control of air potato (Dioscorea bulbifera). Based on its finding of no significant...

  10. Environmental Assessment and Finding of No Significant Impact: Pond B Dam Repair Project at the Savannah River Site

    SciTech Connect

    N /A

    1999-09-27

    The Department of Energy (DOE) has prepared an environmental assessment (EA) (DOE/EA-1285) for the proposed repair of the Pond B dam at the Savannah River Site (SRS), located near Aiken, South Carolina. Based on the analyses in the EA, DOE has determined that the proposed action is not a major Federal action significantly affecting the quality of the human environment within the meaning of the National Environmental Policy Act of 1969 (NEPA). Therefore, the preparation of an environmental impact statement (EIS) is not required, and DOE is issuing this Finding of No Significant Impact (FONSI) and Floodplain Statement of Findings.

  11. Environmental Assessment and Finding of No Significant Impact: Implementation of the Wetland Mitigation Bank Program at the Savannah River Site

    SciTech Connect

    N /A

    1999-04-28

    The Department of Energy (DOE) has prepared an environmental assessment (EA) (DOE/EA-1205) for the proposed implementation of a wetland mitigation bank program at the Savannah River Site (SRS), located near Aiken, South Carolina. Based on the analyses in the EA, DOE has determined that the proposed action is not a major Federal action significantly affecting the quality of the human environment within the meaning of the National Environmental Policy Act of 1969 (NEPA). Therefore, the preparation of an environmental impact statement (EIS) is not required, and DOE is issuing this Finding of No Significant Impact (FONSI) and Floodplain Statement of Findings.

  12. Frequency and Clinical Significance of Previously Undetected Incidental Findings Detected on Computed Tomography Simulation Scans for Breast Cancer Patients

    SciTech Connect

    Nakamura, Naoki; Tsunoda, Hiroko; Takahashi, Osamu; Kikuchi, Mari; Honda, Satoshi; Shikama, Naoto; Akahane, Keiko; Sekiguchi, Kenji

    2012-11-01

    Purpose: To determine the frequency and clinical significance of previously undetected incidental findings found on computed tomography (CT) simulation images for breast cancer patients. Methods and Materials: All CT simulation images were first interpreted prospectively by radiation oncologists and then double-checked by diagnostic radiologists. The official reports of CT simulation images for 881 consecutive postoperative breast cancer patients from 2009 to 2010 were retrospectively reviewed. Potentially important incidental findings (PIIFs) were defined as any previously undetected benign or malignancy-related findings requiring further medical follow-up or investigation. For all patients in whom a PIIF was detected, we reviewed the clinical records to determine the clinical significance of the PIIF. If the findings from the additional studies prompted by a PIIF required a change in management, the PIIF was also recorded as a clinically important incidental finding (CIIF). Results: There were a total of 57 (6%) PIIFs. The 57 patients in whom a PIIF was detected were followed for a median of 17 months (range, 3-26). Six cases of CIIFs (0.7% of total) were detected. Of the six CIIFs, three (50%) cases had not been noted by the radiation oncologist until the diagnostic radiologist detected the finding. On multivariate analysis, previous CT examination was an independent predictor for PIIF (p = 0.04). Patients who had not previously received chest CT examinations within 1 year had a statistically significantly higher risk of PIIF than those who had received CT examinations within 6 months (odds ratio, 3.54; 95% confidence interval, 1.32-9.50; p = 0.01). Conclusions: The rate of incidental findings prompting a change in management was low. However, radiation oncologists appear to have some difficulty in detecting incidental findings that require a change in management. Considering cost, it may be reasonable that routine interpretations are given to those who have not

  13. 76 FR 8708 - Availability of an Environmental Assessment and Finding of No Significant Impact for a Biological...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-15

    ... published in the Federal Register (75 FR 69396, Docket No. APHIS-2010-0108) a notice \\1\\ announcing the... Animal and Plant Health Inspection Service Availability of an Environmental Assessment and Finding of No Significant Impact for a Biological Control Agent for Arundo donax AGENCY: Animal and Plant Health...

  14. 24 CFR 58.43 - Dissemination and/or publication of the findings of no significant impact.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... entity makes a finding of no significant impact, it must prepare a FONSI notice, using the current HUD-recommended format or an equivalent format. As a minimum, the responsible entity must send the FONSI notice to... may also publish the FONSI notice in a newspaper of general circulation in the affected community....

  15. 24 CFR 58.43 - Dissemination and/or publication of the findings of no significant impact.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... entity makes a finding of no significant impact, it must prepare a FONSI notice, using the current HUD-recommended format or an equivalent format. As a minimum, the responsible entity must send the FONSI notice to... may also publish the FONSI notice in a newspaper of general circulation in the affected community....

  16. 78 FR 55330 - Notice of Approval of Finding of No Significant Impact (FONSI) for Murdo Municipal Airport, Murdo...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-10

    ... Federal Aviation Administration Notice of Approval of Finding of No Significant Impact (FONSI) for Murdo... Murdo Municipal Airport, Murdo, South Dakota. The FAA approved the FONSI on August 22, 2013. SUPPLEMENTARY INFORMATION: The FONSI approved the Sponsor's proposed action to extend primary Runway...

  17. 77 FR 32173 - Notice of Availability of the Finding of No Significant Impact: Union and Henderson Counties, KY

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-31

    ... Administration procedures, the FHWA announces the availability of the Finding of No Significant Impact (FONSI) to... Henderson Counties, Kentucky. The Division Administrator, FHWA-Kentucky Division signed the FONSI on April 9, 2012. ADDRESSES: The FHWA FONSI for the US 60 Capacity and Safety Improvement project can be viewed...

  18. 24 CFR 58.43 - Dissemination and/or publication of the findings of no significant impact.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... entity makes a finding of no significant impact, it must prepare a FONSI notice, using the current HUD-recommended format or an equivalent format. As a minimum, the responsible entity must send the FONSI notice to... may also publish the FONSI notice in a newspaper of general circulation in the affected community....

  19. 76 FR 20435 - Notice of Approval of the Supplemental Finding of No Significant Impact and Record of Decision...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-12

    ... Supplemental Finding ] of No Significant Impact/Record of Decision (FONSI/ROD) for the Supplemental.... The Supplemental FONSI/ROD provides final agency determinations and approvals for the proposed...). SUPPLEMENTARY INFORMATION: The Supplemental FONSI/ROD is for the approval of actions for proposed changes to...

  20. 24 CFR 58.43 - Dissemination and/or publication of the findings of no significant impact.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... entity makes a finding of no significant impact, it must prepare a FONSI notice, using the current HUD-recommended format or an equivalent format. As a minimum, the responsible entity must send the FONSI notice to... may also publish the FONSI notice in a newspaper of general circulation in the affected community....

  1. 77 FR 67862 - Notice of Availability of the Final Environmental Assessment (EA) and Finding of No Significant...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-14

    ... Finding of No Significant Impact/Record of Decision (FONSI/ROD) for the Aberdeen Regional Airport in... of a Final EA and FONSI/ROD. SUMMARY: The FAA has issued the final EA final Environmental Assessment (EA) for the Aberdeen Regional Airport Updates and FONSI/ROD for the proposed decoupling of runways...

  2. 24 CFR 58.43 - Dissemination and/or publication of the findings of no significant impact.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... entity makes a finding of no significant impact, it must prepare a FONSI notice, using the current HUD-recommended format or an equivalent format. As a minimum, the responsible entity must send the FONSI notice to... may also publish the FONSI notice in a newspaper of general circulation in the affected community....

  3. 75 FR 38148 - Finding of No Significant Impact Related to Approval of the Mallinckrodt C-T Phase 2...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-01

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Finding of No Significant Impact Related to Approval of the Mallinckrodt C-T Phase 2 Decommissioning Plan; Mallinckrodt, Inc.; St. Louis, MO The U.S. Nuclear Regulatory Commission (NRC) is considering approval of the Mallinckrodt Inc....

  4. 76 FR 13597 - Availability of an Environmental Assessment and Finding of No Significant Impact for a Biological...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-14

    ..., 2010, we published in the Federal Register (75 FR 64984-64985, Docket No. APHIS-2010-0078) a notice \\1... Assessment and Finding of No Significant Impact for a Biological Control Agent for Hawkweeds AGENCY: Animal... subterminalis, into the continental United States as a biological control agent to reduce the severity...

  5. 78 FR 146 - Notice of Availability of Final Environmental Assessment and Finding of No Significant Impact for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-02

    ... Assessment (FEA) and Finding of No Significant Impact (FONSI) for the Longhorn Pipeline Reversal Project (Project). PHMSA has posted the FEA and FONSI online at http://www.regulations.gov in docket number PHMSA... Longhorn Pipeline than it would have under normal circumstances. Accordingly, PHMSA has issued an FEA...

  6. 76 FR 45780 - Notice of Availability for a Finding of No Significant Impact and Environmental Assessment for...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-01

    ... Deepwater Horizon Oil Spill Response AGENCY: National Marine Fisheries Service (NMFS), National Oceanic and... Oil Spill Response (EA) was completed by NOAA, and a Finding of No Significant Impact (FONSI) was... seagrass beds that resulted from Deepwater Horizon (DWH) oil spill response activities. The injuries...

  7. 75 FR 14637 - James A. FitzPatrick Nuclear Power Plant; Environmental Assessment and Finding of No Significant...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-26

    ... COMMISSION James A. FitzPatrick Nuclear Power Plant; Environmental Assessment and Finding of No Significant...), for the operation of the James A. FitzPatrick Nuclear Power Plant (JAFNPP) located in Oswego County... related to operation of James A. FitzPatrick Nuclear Power Plant Power Authority of the State of New...

  8. 78 FR 58517 - Notice of Availability of the Record of Decision (ROD) and Finding of No Significant Impact...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-24

    ... Natural Resources Conservation Service Notice of Availability of the Record of Decision (ROD) and Finding of No Significant Impact (FONSI) for the Bayou Meto Basin Project, Arkansas AGENCY: Natural Resources... Natural Resources Conservation Service, Room 3416, Federal Building, 700 West Capitol Avenue, Little...

  9. Finding of no significant impact for the tritium facility modernization and consolidation project at the Savannah River Site

    SciTech Connect

    1998-01-01

    The Department of Energy (DOE) has prepared an environmental assessment (EA) (DOE/EA-1222) for the proposed modernization and consolidation of the existing tritium facilities at the Savannah River Site (SRS), located near Aiken, South Carolina. Based on the analyses in the EA, DOE has determined that the proposed action is not a major Federal action significantly affecting the quality of the human environment within the meaning of the National Environmental Policy Act of 1969 (NEPA). Therefore, the preparation of an environmental impact statement (EIS) is not required, and DOE is issueing this Finding of No Significant Impact (FONSI).

  10. Final Environmental Assessment and Finding of No Significant Impact: Waste Disposition Activities at the Paducah Site Paducah, Kentucky

    SciTech Connect

    N /A

    2002-11-05

    The U.S. Department of Energy (DOE) has completed an environmental assessment (DOE/EA-1339), which is incorporated herein by reference, for proposed disposition of polychlorinated biphenyl (PCB) wastes, low-level radioactive waste (LLW), mixed low-level radioactive waste (MLLW), and transuranic (TRU) waste from the Paducah Gaseous Diffusion Plant Site (Paducah Site) in Paducah, Kentucky. All of the wastes would be transported for disposal at various locations in the United States. Based on the results of the impact analysis reported in the EA, DOE has determined that the proposed action is not a major federal action that would significantly affect the quality of the human environment with in the context of the National Environmental Policy Act of 1969 (NEPA). Therefore, preparation of an environmental impact statement is not necessary, and DOE is issuing this Finding of No Significant Impact (FONSI).

  11. Finding of no significant impact proposed corrective action for the Northeast Site at the Pinellas Plant in Largo, Florida

    SciTech Connect

    1995-06-01

    The U.S. Department of Energy (DOE) has prepared an Environmental Assessment (EA) (DOE/EA-0976) of the proposed corrective action for the Northeast Site at the Pinellas Plant in Largo, Florida. The Northeast Site contains contaminated groundwater that would be removed, treated, and discharged to the Pinellas County Sewer System. Based on the analyses in the EA, the DOE has determined that the proposed action is not a major Federal action significantly affecting the quality of the human environment, within the meaning of the National Environmental Policy Act of 1969 (NEPA), 42 U.S.C.4321 et.seq. Therefore, the preparation of an environmental impact statement is not required and the DOE is issuing this Finding of No Significant Impact (FONSI).

  12. Caroline pipeline failure: Findings on corrosion mechanisms in wet sour gas systems containing significant CO{sub 2}

    SciTech Connect

    Bich, N.N.; Goerz, K.

    1996-08-01

    A leak occurred in the 5-32S flowline between Junction 1 and the South Compressor Station in the Canada Limited Caroline Complex gathering system near Sundre, Alberta, due to internal wet H{sub 2}S (hydrogen sulfide) and CO{sub 2} (carbon dioxide) pitting corrosion at the bottom of the pipeline. The significant contributing factors to the extremely high pitting corrosion rate, approximately 30 mm/y (1,200 mpy), are considered to be unexpectedly high amounts of chloride ions in the produced well fluids, settling of the produced water under low flow conditions, high condensate/water ratio, inadequate inhibition and pigging, and insufficient monitoring programs. Corrosion mechanisms in sour gas gathering systems with significant CO{sub 2} concentration were reviewed. Preliminary findings pointed to CO{sub 2} partial pressure, not H{sub 2}S, as a main corrosion rate determining factor. The steps taken to prevent similar future incidents were also reviewed.

  13. Prognostic significance of intraoperative macroscopic serosal invasion finding when it shows a discrepancy in pathologic result gastric cancer

    PubMed Central

    Kang, Sang Yull; Park, Ho Sung

    2016-01-01

    Purpose Depth of wall invasion is an important prognostic factor in patients with gastric cancer, whereas the prognostic significance of intraoperative macroscopic serosal invasion (mSE) findings remain unclear when they show a discrepancy in pathologic findings. This study, therefore, assessed the prognostic significance of mSE. Methods Data from cohort of 2,835 patients with resectable gastric cancer who underwent surgery between 1990 and 2010 were retrospectively reviewed. Results The overall accuracy of mSE and pathologic results was 83.4%. The accuracy of mSE was 75.5% in pT2. On the other hand, the accuracy of pT3 dropped to 24.5%. According to mSE findings (+/–), the 5-year disease-specific survival (DSS) rate differed significantly in patients with pT2 (+; 74.2% vs. –; 92.0%), pT3 (+; 76.7% vs. –; 91.8%) and pT4a (+; 51.3% vs. –; 72.8%) (P < 0.001 each), but not in patients with T1 tumor. Multivariate analysis showed that mSE findings (hazard ratio [HR], 2.275; 95% confidence interval [CI], 1.148–4.509), tumor depth (HR, 6.894; 95% CI, 2.325–20.437), nodal status (HR, 5.206; 95% CI, 2.298–11.791), distant metastasis (HR, 2.881; 95% CI, 1.388–6.209), radical resection (HR, 2.002; 95% CI, 1.017–3.940), and lymphatic invasion (HR, 2.713; 95% CI, 1.424–5.167) were independent predictors of 5-year DSS rate. Conclusion We observed considerable discrepancies between macroscopic and pathologic diagnosis of serosal invasion. However, macroscopic diagnosis of serosal invasion was independently prognostic of 5-year DSS. It suggests that because the pathologic results could not be perfect and the local inflammatory change with mSE(+) could affect survival, a combination of mSE(+/–) and pathologic depth may be predictive of prognosis in patients with gastric cancer. PMID:27186569

  14. Feasibility, Yield, and Cost of Active Tuberculosis Case Finding Linked to a Mobile HIV Service in Cape Town, South Africa: A Cross-sectional Study

    PubMed Central

    Kranzer, Katharina; Lawn, Stephen D.; Meyer-Rath, Gesine; Vassall, Anna; Raditlhalo, Eudoxia; Govindasamy, Darshini; van Schaik, Nienke; Wood, Robin; Bekker, Linda-Gail

    2012-01-01

    Background The World Health Organization is currently developing guidelines on screening for tuberculosis disease to inform national screening strategies. This process is complicated by significant gaps in knowledge regarding mass screening. This study aimed to assess feasibility, uptake, yield, treatment outcomes, and costs of adding an active tuberculosis case-finding program to an existing mobile HIV testing service. Methods and Findings The study was conducted at a mobile HIV testing service operating in deprived communities in Cape Town, South Africa. All HIV-negative individuals with symptoms suggestive of tuberculosis, and all HIV-positive individuals regardless of symptoms were eligible for participation and referred for sputum induction. Samples were examined by microscopy and culture. Active tuberculosis case finding was conducted on 181 days at 58 different sites. Of the 6,309 adults who accessed the mobile clinic, 1,385 were eligible and 1,130 (81.6%) were enrolled. The prevalence of smear-positive tuberculosis was 2.2% (95% CI 1.1–4.0), 3.3% (95% CI 1.4–6.4), and 0.4% (95% CI 1.4 015–6.4) in HIV-negative individuals, individuals newly diagnosed with HIV, and known HIV, respectively. The corresponding prevalence of culture-positive tuberculosis was 5.3% (95% CI 3.5–7.7), 7.4% (95% CI 4.5–11.5), 4.3% (95% CI 2.3–7.4), respectively. Of the 56 new tuberculosis cases detected, 42 started tuberculosis treatment and 34 (81.0%) completed treatment. The cost of the intervention was US$1,117 per tuberculosis case detected and US$2,458 per tuberculosis case cured. The generalisability of the study is limited to similar settings with comparable levels of deprivation and TB and HIV prevalence. Conclusions Mobile active tuberculosis case finding in deprived populations with a high burden of HIV and tuberculosis is feasible, has a high uptake, yield, and treatment success. Further work is now required to examine cost-effectiveness and affordability and

  15. Yields of biologically significant damage produced in mammalian DNA by irradiation associated with radon decay. Final progress report

    SciTech Connect

    Ward, J.F.

    1994-03-01

    The objective of this project was to characterize the difference between damage to DNA caused by alpha particles and by low LET radiation. Estimation of the risk posed by exposure to high LET radiation (such as that from radon) relies at present on epidemiological data, and is therefore largely empirical. This empiricism is evident from the concepts of quality factor or RBE that find use for describing the biological effects of high LET radiation. The author argues that some effort should be made to address the mechanisms of DNA damage by high and low LET forms of radiation, and how these mechanisms might relate to the biological endpoints. This report summarizes the results of the author`s investigations and the current understanding of these mechanisms.

  16. Dimension Reduction via Unsupervised Learning Yields Significant Computational Improvements for Support Vector Machine Based Protein Family Classification.

    SciTech Connect

    Webb-Robertson, Bobbie-Jo M.; Matzke, Melissa M.; Oehmen, Christopher S.

    2009-02-26

    Reducing the dimension of vectors used in training support vector machines (SVMs) results in a proportional speedup in training time. For large-scale problems this can make the difference between tractable and intractable training tasks. However, it is critical that classifiers trained on reduced datasets perform as reliably as their counterparts trained on high-dimensional data. We assessed principal component analysis (PCA) and sequential project pursuit (SPP) as dimension reduction strategies in the biology application of classifying proteins into well-defined functional ‘families’ (SVM-based protein family classification) by their impact on run-time, sensitivity and selectivity. Homology vectors of 4352 elements were reduced to approximately 2% of the original data size without significantly affecting accuracy using PCA and SPP, while leading to approximately a 28-fold speedup in run-time.

  17. Environmental Assessment and Finding of No Significant Impact: Wind Energy Center Edgeley/Kulm Project, North Dakota

    SciTech Connect

    N /A

    2003-04-15

    The proposed Edgeley/Kulm Project is a 21-megawatt (MW) wind generation project proposed by Florida Power and Light (FPL) Energy North Dakota Wind LLC (Dakota Wind) and Basin Electric Power Cooperative (Basin). The proposed windfarm would be located in La Moure County, south central North Dakota, near the rural farming communities of Kulm and Edgeley. The proposed windfarm is scheduled to be operational by the end of 2003. Dakota Wind and other project proponents are seeking to develop the proposed Edgeley/Kulm Project to provide utilities and, ultimately, electric energy consumers with electricity from a renewable energy source at the lowest possible cost. A new 115-kilovolt (kV) transmission line would be built to transmit power generated by the proposed windfarm to an existing US Department of Energy Western Area Power Administration (Western) substation located near Edgeley. The proposed interconnection would require modifying Western's Edgeley Substation. Modifying the Edgeley Substation is a Federal proposed action that requires Western to review the substation modification and the proposed windfarm project for compliance with Section 102(2) of the National Environmental Policy Act (NEPA) of 1969, 42 U.S.C. 4332, and Department of Energy NEPA Implementing Procedures (10 CFR Part 1021). Western is the lead Federal agency for preparation of this Environmental Assessment (EA). The US Fish and Wildlife Service (USFWS) is a cooperating agency with Western in preparing the EA. This document follows regulation issued by the Council on Environmental Quality (CEQ) for implementing procedural provisions of NEPA (40 CFR 1500-1508), and is intended to disclose potential impacts on the quality of the human environment resulting from the proposed project. If potential impacts are determined to be significant, preparation of an Environmental Impact Statement would be required. If impacts are determined to be insignificant, Western would complete a Finding of No Significant

  18. Proposed fish passage improvements at Three Mile Falls Diversion Dam, Umatilla River, Oregon: Finding of no significant impact

    SciTech Connect

    Not Available

    1986-05-01

    The Bureau of Reclamation proposes to administer the construction of fish passage and protective facilities at Three Mile Falls Diversion Dam on the Umatilla River in Oregon to increase the numbers of anadromous fish. The Bonneville Power Administration (BPA) proposes to provide funding for the project. These agencies' actions would implement section 904(d) of the Northwest Power Planning Council's Columbia River Basin Fish and Wildlife Program which addresses the provision of offsite enhancement to compensate for fish and wildlife losses caused by hydroelectric project development and operations throughout the Columbia River Basin. This Finding of No Significant Impact (FONSI) is the National Environmental Policy Act (NEPA) decision document for both agencies. The proposed action would improve both upstream and downstream passage by providing a new right bank ladder on Three Mile Falls Diversion Dam, modifying the existing left bank ladder, and installing rotary drum fish screens and related structures on the adjacent West Extension Irrigation District (WEID) Canal. Four other alternatives are considered in the environmental assessment (EA): a concrete apron plus a left bank ladder; a cap on the crest of the dam plus a left bank ladder; dam removal; and no action. 5 figs., 6 tabs.

  19. Clinical significance of discordant findings between pre-therapy (123)I and post-therapy (131)I whole body scan in patients with thyroid cancer.

    PubMed

    Bravo, Paco E; Goudarzi, Behnaz; Rana, Uzma; Filho, Paulo Togni; Castillo, Raymond; Rababy, Christopher; Ewertz, Marjorie; Ziessman, Harvey A; Cooper, David S; Ladenson, Paul W; Wahl, Richard L

    2013-01-01

    Radioactive therapy with (131)I (RAI) is commonly used during the management of patients with differentiated thyroid cancer (DTC). The aim of this study was to determine the clinical significance of discordant findings between pre-RAI whole body scan (WBS) with (123)I and post-RAI WBS in the management of DTC. We retrospectively evaluated 342 individuals between 2002 and 2008 who had a diagnosis of DTC and underwent RAI. All had WBS one day before RAI and WBS one week after RAI. Patients were divided into 3 groups: 1) RAI-naive subjects without known distant metastatic disease (M1); 2) patients with history of prior RAI and persistent disease (except M1); and 3) patients with known M1. In Group 1 (n=311), 7% of patients (n=22) had discordant scans, but in only 4 of these cases did this represent true disease (3 unsuspected lung and 1 mediastinal node metastasis). In the remaining 18 patients, discordant findings corresponded to physiologic or other benign causes. In group 2 (n=23), 7 subjects (30%) had discordant findings and all of the discrepant sites consisted of loco-regional nodal disease in the neck/upper mediastinum (n=6) and M1 in lung (n=1). In group 3 (n=8), 5 patients (62%) showed discordant uptake in lung and bone which corresponded to the locations of known M1. A total of 12 patients with iodine-avid M1 were identified on post-RAI WBS (3.5% of entire cohort). Pre-RAI WBS was only concordant in 3 of these cases (25%). In conclusion, the significance of pre and post-RAI WBS is highly influenced by the clinical setting. Unsuspected distant metastatic disease is infrequent in RAI-naive patients without known M1, where most discordant findings are usually due to benign explanations, and represent false positive findings in this group. In contrast, in patients with history of previous RAI or known M1, discordant results likely correspond to true disease. In our study, pre-RAI scans showed a low yield to detect iodine-avid distant metastatic disease when

  20. The in vitro mass-produced model mycorrhizal fungus, Rhizophagus irregularis, significantly increases yields of the globally important food security crop cassava.

    PubMed

    Ceballos, Isabel; Ruiz, Michael; Fernández, Cristhian; Peña, Ricardo; Rodríguez, Alia; Sanders, Ian R

    2013-01-01

    The arbuscular mycorrhizal symbiosis is formed between arbuscular mycorrhizal fungi (AMF) and plant roots. The fungi provide the plant with inorganic phosphate (P). The symbiosis can result in increased plant growth. Although most global food crops naturally form this symbiosis, very few studies have shown that their practical application can lead to large-scale increases in food production. Application of AMF to crops in the tropics is potentially effective for improving yields. However, a main problem of using AMF on a large-scale is producing cheap inoculum in a clean sterile carrier and sufficiently concentrated to cheaply transport. Recently, mass-produced in vitro inoculum of the model mycorrhizal fungus Rhizophagus irregularis became available, potentially making its use viable in tropical agriculture. One of the most globally important food plants in the tropics is cassava. We evaluated the effect of in vitro mass-produced R. irregularis inoculum on the yield of cassava crops at two locations in Colombia. A significant effect of R. irregularis inoculation on yield occurred at both sites. At one site, yield increases were observed irrespective of P fertilization. At the other site, inoculation with AMF and 50% of the normally applied P gave the highest yield. Despite that AMF inoculation resulted in greater food production, economic analyses revealed that AMF inoculation did not give greater return on investment than with conventional cultivation. However, the amount of AMF inoculum used was double the recommended dose and was calculated with European, not Colombian, inoculum prices. R. irregularis can also be manipulated genetically in vitro, leading to improved plant growth. We conclude that application of in vitro R. irregularis is currently a way of increasing cassava yields, that there is a strong potential for it to be economically profitable and that there is enormous potential to improve this efficiency further in the future. PMID:23950975

  1. The Welsh study of mothers and babies: protocol for a population-based cohort study to investigate the clinical significance of defined ultrasound findings of uncertain significance

    PubMed Central

    2014-01-01

    Background Improvement in ultrasound imaging has led to the identification of subtle non-structural markers during the 18 – 20 week fetal anomaly scan, such as echogenic bowel, mild cerebral ventriculomegaly, renal pelvicalyceal dilatation, and nuchal thickening. These markers are estimated to occur in between 0.6% and 4.3% of pregnancies. Their clinical significance, for pregnancy outcomes or childhood morbidity, is largely unknown. The aim of this study is to estimate the prevalence of seven markers in the general obstetric population and establish a cohort of children for longer terms follow-up to assess the clinical significance of these markers. Methods/Design All women receiving antenatal care within six of seven Welsh Health Boards who had an 18 to 20 week ultrasound scan in Welsh NHS Trusts between July 2008 and March 2011 were eligible for inclusion. Data were collected on seven markers (echogenic bowel, cerebral ventriculomegaly, renal pelvicalyceal dilatation, nuchal thickening, cardiac echogenic foci, choroid plexus cysts, and short femur) at the time of 18 – 20 week fetal anomaly scan. Ultrasound records were linked to routinely collected data on pregnancy outcomes (work completed during 2012 and 2013). Images were stored and reviewed by an expert panel. The prevalence of each marker (reported and validated) will be estimated. A projected sample size of 23,000 will allow the prevalence of each marker to be estimated with the following precision: a marker with 0.50% prevalence to within 0.10%; a marker with 1.00% prevalence to within 0.13%; and a marker with 4.50% prevalence to within 0.27%. The relative risk of major congenital abnormalities, stillbirths, pre-term birth and small for gestational age, given the presence of a validated marker, will be reported. Discussion This is a large, prospective study designed to estimate the prevalence of markers in a population-based cohort of pregnant women and to investigate associations with adverse

  2. Heat waves imposed during early pod development in soybean (Glycine max) cause significant yield loss despite a rapid recovery from oxidative stress.

    PubMed

    Siebers, Matthew H; Yendrek, Craig R; Drag, David; Locke, Anna M; Rios Acosta, Lorena; Leakey, Andrew D B; Ainsworth, Elizabeth A; Bernacchi, Carl J; Ort, Donald R

    2015-08-01

    Heat waves already have a large impact on crops and are predicted to become more intense and more frequent in the future. In this study, heat waves were imposed on soybean using infrared heating technology in a fully open-air field experiment. Five separate heat waves were applied to field-grown soybean (Glycine max) in central Illinois, three in 2010 and two in 2011. Thirty years of historical weather data from Illinois were analyzed to determine the length and intensity of a regionally realistic heat wave resulting in experimental heat wave treatments during which day and night canopy temperatures were elevated 6 °C above ambient for 3 days. Heat waves were applied during early or late reproductive stages to determine whether and when heat waves had an impact on carbon metabolism and seed yield. By the third day of each heat wave, net photosynthesis (A), specific leaf weight (SLW), and leaf total nonstructural carbohydrate concentration (TNC) were decreased, while leaf oxidative stress was increased. However, A, SLW, TNC, and measures of oxidative stress were no different than the control ca. 12 h after the heat waves ended, indicating rapid physiological recovery from the high-temperature stress. That end of season seed yield was reduced (~10%) only when heat waves were applied during early pod developmental stages indicates the yield loss had more to do with direct impacts of the heat waves on reproductive process than on photosynthesis. Soybean was unable to mitigate yield loss after heat waves given during late reproductive stages. This study shows that short high-temperature stress events that reduce photosynthesis and increase oxidative stress resulted in significant losses to soybean production in the Midwest, U.S. The study also suggests that to mitigate heat wave-induced yield loss, soybean needs improved reproductive and photosynthetic tolerance to high but increasingly common temperatures. PMID:25845935

  3. 75 FR 39325 - Notice of Draft Finding of No Significant Impact for the Washington State Portion of the Pacific...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-08

    ... WSDOT applied for federal funding through the High Speed Intercity Passenger Rail Program (HSIPR Program... Portion of the Pacific Northwest Rail Corridor Upgrades Tier-1 Environmental Assessment AGENCY: Federal... Northwest Rail Corridor (PNWRC Program). Based on the Tier-1 EA, the FRA has prepared a draft finding of...

  4. 78 FR 14508 - Availability of an Environmental Assessment and Finding of No Significant Impact for the Field...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-06

    .... On August 3, 2012, we published in the Federal Register (77 FR 46373, Docket No. APHIS-2012-0061) a... Animal and Plant Health Inspection Service Availability of an Environmental Assessment and Finding of No... in the Continental United States AGENCY: Animal and Plant Health Inspection Service, USDA. ]...

  5. 76 FR 50170 - Pohick Creek Watershed Dam No. 8, Fairfax County, Virginia; Finding of No Significant Impact

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-12

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF AGRICULTURE Natural Resources Conservation Service Pohick Creek Watershed Dam No. 8, Fairfax County, Virginia; Finding... Creek Watershed Dam No. 8, Fairfax County, Virginia. FOR FURTHER INFORMATION CONTACT: John A....

  6. 78 FR 58517 - Notice of Availability of the Record of Decision (ROD) and Findings of No Significant Impact...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-09-24

    ... of No Significant Impact (FONSI) for the Grand Prairie Area Demonstration Project AGENCY: Natural...) entitled: ``General Reevaluation Report and Environmental Impact Statement for the Grand Prairie...: ``Environmental Assessment Grand Prairie Area Demonstration Project, Post General Reevaluation Design...

  7. Natalizumab Significantly Improves Cognitive Impairment over Three Years in MS: Pattern of Disability Progression and Preliminary MRI Findings

    PubMed Central

    Mattioli, Flavia; Stampatori, Chiara; Bellomi, Fabio; Scarpazza, Cristina; Capra, Ruggero

    2015-01-01

    Previous studies reported that Multiple Sclerosis (MS) patients treated with natalizumab for one or two years exhibit a significant reduction in relapse rate and in cognitive impairment, but the long term effects on cognitive performance are unknown. This study aimed to evaluate the effects of natalizumab on cognitive impairment in a cohort of 24 consecutive patients with relapsing remitting MS treated for 3 years. The neuropsychological tests, as well as relapse number and EDSS, were assessed at baseline and yearly for three years. The impact on cortical atrophy was also considered in a subgroup of them, and are thus to be considered as preliminary. Results showed a significant reduction in the number of impaired neuropsychological tests after three years, a significant decrease in annualized relapse rate at each time points compared to baseline and a stable EDSS. In the neuropsychological assessment, a significant improvement in memory, attention and executive function test scores was detected. Preliminary MRI data show that, while GM volume did not change at 3 years, a significantly greater parahippocampal and prefrontal gray matter density was noticed, the former correlating with neuropsychological improvement in a memory test. This study showed that therapy with Natalizumab is helpful in improving cognitive performance, and is likely to have a protective role on grey matter, over a three years follow-up. PMID:26148120

  8. 76 FR 42675 - Availability of an Environmental Assessment and Finding of No Significant Impact for a Biological...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-19

    ... biological control agent to reduce the severity of hemlock woolly adelgid (Adelges tsugae, HWA) infestations. On January 19, 2011, we published in the Federal Register (75 FR 28232-28233, Docket No. APHIS-2010... Significant Impact for a Biological Control Agent for Hemlock Woolly Adelgid AGENCY: Animal and Plant...

  9. 76 FR 42121 - Final Notice of a Finding of No Significant Impact for a Programmatic Environmental Assessment...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-18

    ... Assessment Implementing a Wind Energy Program at Marine Forces Reserve Facilities Located Across the United... Programmatic Environmental Assessment (PEA) Implementing a Wind Energy Program at Marine Forces Reserve... the MARFORRES Wind Energy Program will not have a significant adverse impact on the environment....

  10. 78 FR 29201 - Notice of Availability of Finding of No Significant Impact for the Proposed Vantage Pipeline US...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-17

    ..., operation, and maintenance of the Cross Border Facility would not have a significant impact on the quality... construction, connection, operation, or maintenance at the borders of the United States, of facilities for the... seq.), the regulations of the Council on Environmental Quality (40 CFR parts 1500-1508), and...

  11. 76 FR 59174 - Environmental Assessment and Finding of No Significant Impact for the N.S. Savannah; License NS-1...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-23

    ... significant impact. FOR FURTHER INFORMATION CONTACT: John Hickman, Division of Waste Management and...-mail: john.hickman@nrc.gov . SUPPLEMENTARY INFORMATION: I. Introduction The U.S. Nuclear Regulatory... public documents. If you do not have access to ADAMS, or if there are problems in accessing the...

  12. Cranial magnetic resonance imaging findings of leptomeningeal contrast enhancement after pediatric posterior fossa tumor resection and its significance.

    PubMed

    Loree, Jonathan; Mehta, Vivek; Bhargava, Ravi

    2010-07-01

    In this report, the authors illustrate the potential shortfalls of early postoperative MR imaging following resection of a posterior fossa tumor. The authors present the cases of a 10-month-old boy and a 14-year-old boy with posterior fossa tumors that were surgically resected and monitored immediately postoperatively with MR imaging. The MR imaging study obtained immediately postresection while the children were still anesthetized revealed enhancing elements in both patients, which were suggestive of leptomeningeal metastases. When this signal was followed on subsequent MR images, it was no longer visible. The patients are both recurrence free at the time of this publication. These cases demonstrate that early postoperative MR imaging findings for leptomeningeal metastases may be unreliable after excision of posterior fossa tumors and may have potential implications for intraoperative MR imaging techniques currently under development. PMID:20593993

  13. Environmental assessment, finding of no significant impact, and response to comments. Sold residue treatment, repackaging, and storage

    SciTech Connect

    1996-04-01

    From its founding in 1952 through the cessation of production in 1989, the United States Department of Energy`s (DOE) Rocky Flats Plant (now the Rocky Flats Environmental Technology Site [the Site]) produced components for nuclear weapons. Some of those components were made of plutonium. As a result of the processes used to recover and purify plutonium and manufacture the components, a variety of materials became contaminated with plutonium. If the level of contamination were low, the material was considered waste. However, if the concentration of plutonium in the material exceeded the {open_quotes}economic discard limit,{close_quotes} the materials were classified as {open_quotes}residue{close_quotes} rather than{open_quotes}Waste{close_quotes} and were stored for later recovery of the plutonium. While large quantities of residues were processed, others, primarily those more difficult to process, accumulated at the Site in storage. Two important events regarding residues have occurred at the Site since production activities ceased. One event was the end of the Cold War in 1991, which made the return to production of nuclear weapons, with their Rocky Flats-made components, unnecessary. This event led to DOE`s decision to permanently cease production at the Site, clean up and remove radioactive and chemical contamination at the Site, and find alternative uses for the Site. This document describes methods for processing of the wastes for safe interim storage. Environmental impacts from the processing and storage are discussed.

  14. Lumbar puncture-related cerebrospinal fluid leakage on magnetic resonance myelography: is it a clinically significant finding?

    PubMed Central

    2013-01-01

    Background Post-dural puncture headache (PDPH) due to excessive cerebrospinal fluid (CSF) leakage is a well-known complication of lumbar puncture. Although various factors, especially the type of spinal needle, have been demonstrated to be associated with PDPH, the clinical implications of CSF leakage detected on magnetic resonance myelography (MRM) images remain unclear. The objective of this case–control study was to evaluate the association between radiologically visualized CSF leakage and PDPH. Methods Clinical data including patients’ age and gender, types of spinal needle, duration of bed rest, interval between lumbar puncture procedures and MRM studies, and incidence of PDPH were compared between patients who were radiologically-positive and -negative for CSF leakage. Results Of the 22 patients with definite CSF leakage on MRM images, most were asymptomatic (86%, 19/22). The remaining three patients, who were suffering from PDPH, only complained of headaches and were treated conservatively. In a review of patients’ clinical data, there were no significant differences in any parameter including the incidence of PDPH between the 22 patients who were radiologically-positive for CSF leakage and the 31 radiologically-negative patients. Conclusion The significance of radiologically visualized CSF leakage should not be overestimated, as most such incidents are not associated with PDPH and do not require any treatment. PMID:24160550

  15. [Clinical significance of proteinuria and renal function: findings from a population-based cohort, the Takahata study].

    PubMed

    Konta, Tsuneo

    2013-07-01

    Proteinuria/albuminuria and renal insufficiency are major components of chronic kidney disease (CKD), and are strongly associated with end-stage renal disease, cardiovascular events and premature death. To clarify the prevalence of these renal disorders and the association between renal disorders and mortality in the Japanese population, we conducted a community-based longitudinal study. This study included 3,445 registered Japanese subjects, with a 7-year follow-up. Proteinuria/albuminuria was evaluated using dipstick strips and the urinary protein/albumin creatinine ratio (PCR/ACR). Glomerular filtration rate (GFR) was estimated using the equation for Japanese subjects. The prevalence of dipstick proteinuria, proteinuria (PCR > or = 0.15 g/gCr), albuminuria(ACR > or =30 mg/gCr) and renal insufficiency(estimated GFR< 60 ml/min/1.73m2) were 5%, 8%, 15% and 7%, respectively. The overlap between urinary abnormality and renal insufficiency was small. The prevalence of proteinuria/albuminuria increased along with the increase of blood pressure, 24-hour urinary sodium excretion, HbAlc and the number of components of metabolic syndrome. Kaplan Meier analysis showed that all-cause mortality was significantly increased along with the increase in urinary albumin excretion and the subjects with albuminuria showed a significantly higher mortality rate than those without albuminuria. Cox proportional hazard analysis after adjusting for possible confounders showed that albuminuria was an independent risk for all-cause and cardiovascular mortality. In conclusion, proteinuria/albuminuria and renal insufficiency are prevalent and were independently associated with mortality in the Japanese general population. The detection of renal disorders at the earliest opportunity is important to prevent premature death. PMID:24205706

  16. Environmental Assessment and Finding of No Significant Impact: The National Compact Stellarator Experiment at the Princeton Plasma Physics Laboratory

    SciTech Connect

    N /A

    2002-10-25

    If the United States is to meet the energy needs of the future, it is essential that new technologies emerge to compensate for dwindling supplies of fossil fuels, the eventual depletion of fissionable uranium used in present-day nuclear reactors, and the limitations of solar, hydro and wind alternatives. Fusion energy, the power source of the sun and other stars, has the potential to become a major source of energy for the future. Power from fusion would provide substantially reduced environmental impacts as compared with current forms of energy generation. Thus, the United States and other countries around the world continue to pursue development of fusion energy as one of a number of potential power sources for the long term. Fusion research, using various machine configurations, has been proceeding since the early 1950's, and significant progress has been achieved in performance and in understanding of the underlying physics. For most of this period, fusion machines called stellarators and tokamaks, which are toroidal (doughnut-shaped) devices, have been most frequently used to conduct experiments for producing controlled nuclear fusion. It is now desirable to take a next step in the fusion development program, by providing an experimental device to investigate the attractiveness of a compact stellarator as the basis for a fusion power reactor. This concept has the potential to build upon advances in understanding of stellarators and tokamaks, and to combine the best features of both. The goal is to build a compact stellarator that would be smaller than conventional stellarators and operate more efficiently than previous tokamaks. Such a device would broaden our understanding of magnetic fusion science while contributing to the development of a potentially attractive fusion reactor solution that may have cost advantages over other fusion concepts.

  17. Clinically occult interstitial fibrosis in smokers: classification and significance of a surprisingly common finding in lobectomy specimens.

    PubMed

    Katzenstein, Anna-Luise A; Mukhopadhyay, Sanjay; Zanardi, Conrado; Dexter, Elizabeth

    2010-03-01

    This study reports the presence of surprisingly frequent and often severe interstitial fibrosis in cigarette smokers with no clinical evidence of interstitial lung disease. Twenty-three lobectomy specimens excised for neoplasms, including 20 from smokers, were extensively sampled, and examined semi-quantitatively for interstitial fibrosis, fibroblast foci, peribronchiolar metaplasia, honey-comb change, emphysema, and respiratory bronchiolitis. Interstitial fibrosis involving greater than 25% of slides was identified in 12 of 20 smokers (60%), but in none of the three never-smokers. Three cases were classified as specific forms of interstitial lung disease, including one each of usual interstitial pneumonia, Langerhans cell histiocytosis, and asbestosis. The remaining 9 cases did not fit with a named interstitial lung disease and were considered to represent examples of smoking-related interstitial fibrosis. This lesion was characterized by varying degrees of alveolar septal widening by collagen deposition along with emphysema and respiratory bronchiolitis. The fibrosis occurred both in subpleural and in deeper parenchyma. It surrounded enlarged airspaces of emphysema, but it also involved non-emphysematous parenchyma. Clinical progression was not documented in any case, although follow-up was short. These observations highlight the spectrum of unexpected fibrosis that is frequently encountered in lobectomy specimens from cigarette smokers. Additional investigation will be required to determine the clinical significance of smoking-related interstitial fibrosis and its relationship, if any, to other smoking-related diseases. It is important, however, that smoking-related interstitial fibrosis be distinguished from specific forms of fibrosing lung disease that may be associated with poor prognoses, especially usual interstitial pneumonia. PMID:20004953

  18. Adding multiple micronutrient powders to a homestead food production programme yields marginally significant benefit on anaemia reduction among young children in Nepal.

    PubMed

    Osei, Akoto K; Pandey, Pooja; Spiro, David; Adhikari, Debendra; Haselow, Nancy; De Morais, Caroline; Davis, Dale

    2015-12-01

    Anaemia affects 46% of preschool-aged children in Nepal. A cluster-randomised study was conducted in rural Nepal to test whether providing micronutrient powders (MNP) in addition to enhanced homestead food production (EHFP) programme, consisting of home gardens, poultry and nutrition education, could lead to a higher reduction in anaemia compared with providing only EHFP. This sub-study enrolled 335 children aged 6-9 months into one of three groups: (1) EHFP + MNP; (2) EHFP; or (3) control. The EHFP + MNP group received 60 sachets of MNP for flexible consumption at the start and 6 months later for a total supplementation period of 11 months. The MNP contained 15 micronutrients including iron (10 mg encapsulated ferrous fumarate). Haemoglobin and anthropometry were measured at baseline and post-MNP supplementation. Mean ± SE haemoglobin concentration increased significantly in all groups, with a slightly higher but non-significant increase in the EHFP + MNP and EHFP compared with control (difference-in-differences: 4.1 g L(-1) for EHFP + MNP vs. control; 3.6 g L(-1) for EHFP vs. control; 0.5 g L(-1) for EHFP + MNP vs. EHFP). Anaemia decreased at a slightly higher magnitude in the EHFP + MNP [51.5 percentage points (PP)] than the EHFP (48.6 PP) and control (39.6 PP), with adjusted odds ratios (95% CI) at post-supplementation of 0.52 (0.25-1.12) for EHFP + MNP and 0.69 (0.35-1.36) for EHFP, compared with control. There was no impact on child growth. Combining EHFP and MNP programmes yielded a marginally significant reduction in anaemia among children. PMID:25682798

  19. Singlet-oxygen generation at gas-liquid interfaces: A significant artifact in the measurement of singlet-oxygen yields from ozone-biomolecule reactions

    SciTech Connect

    Kanofsky, J.R.; Sima, P.D. )

    1993-09-01

    Several ozone-biomolecule reactions have previously been shown to generate singlet oxygen in high yields. For some of these ozone-biomolecule reactions, we now show that the apparent singlet-oxygen yields determined from measurements of 1270 nm chemiluminescence were artifactually elevated by production of gas-phase singlet oxygen. The gas-phase singlet oxygen results from the reaction of gas-phase ozone with biomolecules near the surface of the solution. Through the use of a flow system that excludes air from the reaction chamber, accurate singlet-oxygen yields can be obtained. The revised singlet-oxygen yields (mol 1O2 per mol O3) for the reactions of ozone with cysteine, reduced glutathione, NADH, NADPH, human albumin, methionine, uric acid and oxidized glutathione are 0.23 +/- 0.02, 0.26 +/- 0.2, 0.48 +/- 0.04, 0.41 +/- 0.01, 0.53 +/- 0.06, 1.11 +/- 0.04, 0.73 +/- 0.05 and 0.75 +/- 0.01, respectively. These revised singlet-oxygen yields are still substantial.

  20. Finding of No Significant for the Closure of the High-Level Waste Tanks in F-and H-Areas at the Savannah River Site

    SciTech Connect

    N /A

    1996-07-31

    The Department of Energy (DOE) has prepared an environmental assessment (EA) (DOEEA-1164) for the proposed closure of the high-level waste tanks in F- and H-Areas on the Savannah River Site (SRS), near Aiken, South Carolina. Based on the analyses in the EA, DOE has determined that the proposed action is not a major Federal action significantly affecting the quality of the human environment within the meaning of the National Environmental Policy Act (NEPA) of 1969. Therefore, the preparation of an environmental impact statement is not required, and DOE is issuing this Finding of No Significant Impact (FONSI).

  1. Environmental assessment and finding of no significant impact for completion of flood protection works, Bannister Road Federal Complex, Kansas City, Missouri

    SciTech Connect

    Not Available

    1991-09-18

    The Department of Energy (DOE) proposes to provide partial funding to the Corps of Engineers (COE) for the completion of the flood protection works at the Bannister Road Federal Complex in Kansas City, Missouri. The DOE Kansas City Plant is a major tenant of the Complex. COE has prepared an environmental assessment (EA) for the project which includes the construction of levees, floodwalls, and drainage ditches. DOE has adopted the EA prepared by COE (DOE/EA-0509), this report. Based on the analyses in this EA, DOE has determined that the proposed action is not a major Federal action significantly affecting the quality of the human environment, within the meaning of the National Environmental Policy Act (NEPA) of 1969, 42 USC 4321 et seq. Therefore, the preparation of an environmental impact statement is not required, and DOE is issuing this Finding of No Significant Impact (FONSI).

  2. Predictive significance of the overvaluation of shape/weight in obese patients with binge eating disorder: findings from a randomized controlled trial with 12-month follow-up

    PubMed Central

    Grilo, C. M.; White, M. A.; Gueorguieva, R.; Wilson, G. T.; Masheb, R. M.

    2013-01-01

    Background Undue influence of body shape or weight on self-evaluation – referred to as overvaluation – is considered a core feature across eating disorders, but is not a diagnostic requirement for binge eating disorder (BED). This study examined the concurrent and predictive significance of overvaluation of shape/weight in obese patients with BED participating in a randomized clinical trial testing cognitive behavioral therapy (CBT) and behavioral weight loss (BWL). Method A total of 90 participants were randomly assigned to 6-month group treatments of CBT or BWL. Assessments were performed at baseline, throughout- and post-treatment, and at 6- and 12-month follow-ups after completing treatments with reliably administered semi-structured interviews and established measures. Results Participants categorized with overvaluation (n=52, 58%) versus without overvaluation (n=38, 42%) did not differ significantly in demographic features (age, gender and ethnicity), psychiatric co-morbidity, body mass index or binge eating frequency. The overvaluation group had significantly greater levels of eating disorder psychopathology and poorer psychological functioning (higher depression and lower self-esteem) than the non-overvaluation group. Overvaluation of shape/weight significantly predicted non-remission from binge eating and higher frequency of binge eating at the 12-month follow-up, even after adjusting for group differences in depression and self-esteem levels. Conclusions Our findings suggest that overvaluation does not simply reflect concern commensurate with being obese or more frequent binge eating, but also is strongly associated with heightened eating-related psychopathology and psychological distress, and has negative prognostic significance for longer-term treatment outcomes. Overvaluation of shape/weight warrants consideration as a diagnostic specifier for BED as it provides important information about severity and treatment outcome. PMID:22967857

  3. Final Environmental Assessment and Finding of No Significant Impact: Idaho Department of Fish and Game Captive Rearing Initiative for Salmon River Chinook Salmon

    SciTech Connect

    N /A

    2000-10-12

    Bonneville Power Administration (BPA), Department of Energy (DOE), is proposing to fund the Idaho Department of Fish and Game (IDFG) Captive Rearing Initiative for Salmon River Chinook Salmon Program (IDFG Program). The IDFG Program is a small-scale research and production initiative designed to increase numbers of three weak but recoverable populations of spring/summer chinook salmon in the Salmon River drainage. This would increase numbers of spring/summer chinook salmon within the Snake River Spring/Summer Chinook Salmon Evolutionarily Significant Unit (ESU), and reduce population fragmentation within the ESU. BPA has prepared an Environmental Assessment (EA) (DOE/EA-1301) evaluating the proposed IDFG Program. Based on the analysis in the EA, BPA has determined that the Proposed Action is not a major Federal action significantly affecting the quality of the human environment, as defined within the National Environmental Policy Act (NEPA) of 1969. Therefore, the preparation of an Environmental Impact Statement (EIS) is not required, and BPA is issuing this Finding of No Significant Impact (FONSI).

  4. [Clinical studies in working populations: value and significance of anamnestic findings, clinical tests and instrumental tests for the diagnosis of musculoskeletal disorders of the upper extremities].

    PubMed

    De Marco, F; Menoni, O; Ricci, M G; Bonaiuti, D; Colombini, D; Occhipinti, E

    1996-01-01

    The authors discuss the value and significance of symptoms in WMSDs, considering that the anamnestic threshold proposed in epidemiological investigations cannot be used as clinical and diagnosing criteria. Some useful clinical procedures are suggested for cases where there is a suspicion of musculo-skeletal disorders of the cervical spine and upper limbs, bearing in mind that they are to be applied within the framework of health surveillance programmes undertaken by health care practitioners who are not specialists in orthopaedics, physiatrics or neurology. The recommendations for instrumental tests and specialist referrals are also discussed for the various disorders. The authors also provide flow charts for the diagnostic procedures pertaining to WMSDs. The Appendix shows a sample patient chart illustrating the proposed procedures; it also permits the findings to be encoded so that they can be stored in a dedicated database. The codes for diagnosing WMSDs are also reported for the same epidemiological purposes. PMID:9148113

  5. Final Report Regarding the Findings of the Study Group on the Feasibility of Using Alternative Financial Instruments for Determining Lender Yield under the Federal Family Education Loan Program.

    ERIC Educational Resources Information Center

    General Accounting Office, Washington, DC.

    The Higher Education Amendments of 1998 required a study of the feasibility of alternative financial instruments for determining lender yields in the Federal Family Education Loan Program (FFELP) and called for an evaluation of the 91-day Treasury bill, 30-day and 90-day commercial paper, and the 90-day London Interbank Offered Rate (LIBOR) as…

  6. A new direction for prenatal chromosome microarray testing: software-targeting for detection of clinically significant chromosome imbalance without equivocal findings

    PubMed Central

    Bint, Susan; Irving, Melita D.; Kyle, Phillipa M.; Akolekar, Ranjit; Mohammed, Shehla N.; Mackie Ogilvie, Caroline

    2014-01-01

    Purpose. To design and validate a prenatal chromosomal microarray testing strategy that moves away from size-based detection thresholds, towards a more clinically relevant analysis, providing higher resolution than G-banded chromosomes but avoiding the detection of copy number variants (CNVs) of unclear prognosis that cause parental anxiety. Methods. All prenatal samples fulfilling our criteria for karyotype analysis (n = 342) were tested by chromosomal microarray and only CNVs of established deletion/duplication syndrome regions and any other CNV >3 Mb were detected and reported. A retrospective full-resolution analysis of 249 of these samples was carried out to ascertain the performance of this testing strategy. Results. Using our prenatal analysis, 23/342 (6.7%) samples were found to be abnormal. Of the remaining samples, 249 were anonymized and reanalyzed at full-resolution; a further 46 CNVs were detected in 44 of these cases (17.7%). None of these additional CNVs were of clear clinical significance. Conclusion. This prenatal chromosomal microarray strategy detected all CNVs of clear prognostic value and did not miss any CNVs of clear clinical significance. This strategy avoided both the problems associated with interpreting CNVs of uncertain prognosis and the parental anxiety that are a result of such findings. PMID:24795849

  7. Final environmental assessment and Finding-of-No-Significant-Impact - drum storage facility for interim storage of materials generated by environmental restoration operations

    SciTech Connect

    Not Available

    1994-09-01

    The Department of Energy (DOE) has prepared an Environmental Assessment (EA), DOE/EA-0995, for the construction and operation of a drum storage facility at Rocky Flats Environmental Technology Site, Golden, Colorado. The proposal for construction of the facility was generated in response to current and anticipated future needs for interim storage of waste materials generated by environmental restoration operations. A public meeting was held on July 20, 1994, at which the scope and analyses of the EA were presented. The scope of the EA included evaluation of alternative methods of storage, including no action. A comment period from July 5, 1994 through August 4, 1994, was provided to the public and the State of Colorado to submit written comment on the EA. No written comments were received regarding this proposed action, therefore no comment response is included in the Final EA. Based on the analyses in the EA, DOE has determined that the proposed action would not significantly affect the quality of the human environment within the meaning of the National Environmental Policy Act of 1969 (NEPA). Therefore, preparation of an Environmental Impact Statement is not required and the Department is issuing this Finding of No Significant Impact.

  8. Finding of no significant impact: Changes in the sanitary sludge land application program on the Oak Ridge Reservation, Oak Ridge, Tennessee

    SciTech Connect

    1996-10-01

    The U.S. Department of Energy (DOE) has completed an environmental assessment (DOE/EA-1042) that evaluates potential impacts of proposed changes in the sanitary sludge land application program on the DOE Oak Ridge Reservation (ORR), Oak Ridge, Tennessee. Changes in lifetime sludge land application limits and radionuclide loading are proposed, and two new sources of sewage sludge from DOE facilities would be transported to the City of Oak Ridge Publicly Owned Treatment Works (COR POTW). Lifetime sludge land application limits would increase from 22 tons/acre to 50 tons/acre, which is the limit approved and permitted by the Tennessee Department of Environment and Conservation (TDEC). With the approval of TDEC, the permissible radiological dose from sludge land application would change from the current limit of 2x background radionuclide concentrations in receiving soils to a risk-based dose limit of 4 millirem (mrem) per year for the maximally exposed individual. Sludge land application sites would not change from those that are currently part of the program. Based on the results of the analysis reported in the EA, DOE has determined that the proposed action is not a major federal action that would significantly affect the quality of the human environment within the context of the National Environmental Policy Act of 1969 (NEPA). Therefore, preparation of an environmental impact statement (EIS) is not necessary, and DOE is issuing this Finding of No Significant Impact (FONSI). 70 refs., 2 figs., 17 tabs.

  9. Final Environmental Assessment and Finding of No Significant Impact: White Sturgeon Mitigation and Restoration in the Columbia and Snake Rivers Upstream from Bonneville Dam

    SciTech Connect

    N /A

    2003-04-23

    Bonneville Power Administration (BPA) is proposing to fund the White Sturgeon Mitigation and Restoration in the Columbia and Snake Rivers Upstream from Bonneville Dam Project. The project proposes to continue to carry out harvest monitoring and stock status updates coordinated with fisheries management planning, annual young-of-the year recruitment indexing, research, experimental artificial propagation, and transport of white sturgeon to less densely populated areas of the river(s). Additionally, release of hatchery-reared juveniles is proposed to evaluate release strategies. Actions will take place in the following Columbia River mainstem reaches: Bonneville, The Dalles, John Day, and McNary Reservoirs; Hanford Reach, as well as the Wanapum and Rock Island Reservoirs; and the following Snake River mainstem reaches: Ice Harbor, Lower Monumental and Little Goose Reservoirs. Spawning and rearing are undertaken at established hatcheries at McNary Dam and also the Abernathy Fish Technology Center. BPA has prepared an Environmental Assessment (EA) (DOE/EA-1367, April 2003) evaluating the proposed project. Based on the analysis in the EA, BPA has determined that the proposed action is not a major Federal action significantly affecting the quality of the human environment, within the meaning of the National Environmental Policy Act (NEPA) of 1969. Therefore, the preparation of an Environmental Impact Statement (EIS) is not required, and BPA is issuing this Finding of No Significant Impact (FONSI).

  10. Finding of no significant impact for the joint DOE/EPA program on national industrial competitiveness through energy efficiency and economics (NICE{sup 3})

    SciTech Connect

    1997-03-01

    The Department of Energy (DOE) has prepared a Programmatic Environmental Assessment (PEA), to assess the environment impacts associated with a joint DOE/EPA cost-sharing grant program named National Industrial Competitiveness through Energy Efficiency, Environment and Economics (NICE{sup 3}). The purpose of the NICE{sup 3} Program is to encourage waste minimization technology in industry by funding projects that develop activities and process improvements to conserve energy and reduce pollution. The proposed action would provide Federal financial assistance in the form of grants to industry in order to promote pollution prevention, energy efficiency, and cost competitiveness. Based on the analysis presented in the PEA, DOE has determined that the proposed action (providing NICE{sup 3} grants for projects which are consistent with the goals of the PPA and EPACT) does not constitute a major Federal action significantly affecting the quality of the human environment within the meaning of NEPA. Therefore, the preparation of an Environmental Impact Statement is not needed and the Department is issuing this Finding of No Significant Impact.

  11. Revised Finding of No Significant Impact for Expansion and Operation of the Central Shops Borrow Pit at the Savannah River Site (10/29/03)

    SciTech Connect

    N /A

    2003-10-29

    The Department of Energy (DOE) prepared an environmental assessment (EA) (DOE/EA-1194) in 1997 for the expansion and operation of the existing Central Shops Borrow Pit (i.e., SRS Facility 632-G) at the Savannah River Site (SRS), located near Aiken, South Carolina. This EA was prepared in accordance with the National Environmental Policy Act (NEPA) of 1969, as amended; the requirements of the Council on Environmental Quality Regulations for Implementing NEPA (40 CFR 15400-1508); and the DOE Regulations for Implementing NEPA (10 CFR 1021). Based on the analyses in the EA, DOE determined that the action was not a major Federal action significantly affecting the quality of the human environment within the meaning of NEPA. Therefore, the preparation of an environmental impact statement (EIS) was not required, and DOE issued a Finding of No Significant Impact (FONSI) dated March 13, 1997. In an effort to provide the site with cost-effective future landfill capacity for construction and demolition (C&D) debris/structural fill, DOE is considering redefining the closure of the 632-G facility to encompass the permitted disposal of inert C&D debris into the excavation areas, which would then be closed as per regulatory requirements. Based on the existing infrastructure at the 632-G facility that would support a permitted Part III C&D Landfill, DOE has concluded that the environmental impacts of the proposed use of the excavated portions of this facility as an inert debris landfill is not a major Federal action significantly affecting the quality of the human environment within the meaning of NEPA. Therefore, the preparation of an EIS is not required, and DOE is issuing this revised FONSI.

  12. Predictive Significance of a New Prognostic Score for Patients With Diffuse Large B-Cell Lymphoma in the Interim-Positron Emission Tomography Findings

    PubMed Central

    Kong, Yu; Qu, Lili; Li, Yuekai; Liu, Dai; Lv, Xuemin; Han, Jiankui

    2016-01-01

    Abstract We hypothesized that the objective treatment response of patients with diffuse large B-cell lymphoma (DLBCL) was affected by many factors such as pathophysiological, biological, and pharmaceutical mechanisms. This retrospective study aimed to evaluate the predictive significance of clinical prognostic factors and interim fluorine-18-fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT), and to find a new prognostic predictor significantly associated with DLBCL patients’ outcome. A total of 105 adult patients with DLBCL were reviewed. Each patient underwent an interim 18F-FDG PET/CT scan after the second chemotherapy cycle. The visual method based on the Deauville 5-point scale was used to evaluate the interim-PET/CT scans. The relationships among the prognostic factors, the 3-year progression-free survival (PFS) rate and overall survival (OS) rate were analyzed with Kaplan–Meier plots. The predictive value of the newly constructed prognostic score was analyzed with multivariate analysis (Cox proportional hazard regression model). The visual analysis showed statistically significant differences in both PFS and OS between the patients with a negative interim-PET/CT and those with a positive interim-PET/CT. Advanced age, advanced stage, and DLBCL subtype were also significantly associated with outcome. A new prognostic score that composed of the above 4 factors was obtained. New prognostic score stratified patients into 4 risk groups with 3-year PFS of 98.5%, 73.9%, 11.1%, and 0%, and 3-year OS of 100%, 91.3%, 55.6%, and 0% (P < 0.001 for PFS and OS). Multivariate analysis showed that the new prognostic score had the greatest ability to predict relapse (P < 0.001) and death (P < 0.001). In DLBCL patients, interim 18F-FDG PET/CT can provide significant independent prognostic information. Our work illustrates that the new prognostic score has the strongest potential for accurately prognostication, for

  13. Environmental Assessment and Finding of No Significant Impact: Widening Trench 36 of the 218-E-12B Low-Level Burial Ground, Hanford Site, Richland, Washington

    SciTech Connect

    N /A

    1999-02-11

    This environmental assessment was prepared to assess potential environmental impacts associated with the proposed action to widen and operate unused Trench 36 in the 218-E-12B Low-Level Burial Ground for disposal of low-level waste. Information contained herein will be used by the Manager, U.S. Department of Energy, Richland Operations Office, to determine if the Proposed Action is a major federal action significantly affecting the quality of the human environment. If the Proposed Action is determined to be major and significant, an environmental impact statement will be prepared. If the Proposed Action is determined not to be major and significant, a Finding of No Significant Impact will be issued and the action may proceed. Criteria used to evaluate significance can be found in Title 40, Code of Federal Regulations 1508.27. This environmental assessment was prepared in compliance with the ''National Environmental Policy Act of1969'', as amended, the Council on Environmental Quality Regulations for Implementing the Procedural Provisions of ''National Environmental Policy Act'' (Title 40, Code of Federal Regulations 1500-1508), and the U.S. Department of Energy Implementing Procedures for ''National Environmental Polio Act'' (Title 10, Code of Federal Regulations 1021). The following is a description of each section of this environmental assessment. (1) Purpose and Need for Action. This section provides a brief statement concerning the problem or opportunity the U.S, Department of Energy is addressing with the Proposed Action. Background information is provided. (2) Description of the Proposed Action. This section provides a description of the Proposed Action with sufficient detail to identify potential environmental impacts. (3) Alternatives to the Proposed Action. This section describes reasonable,alternative actions to the Proposed Action, which addresses the Purpose and Need. A No Action Alternative, as required by Title 10, Code of Federal Regulations 1021

  14. Significant Increase in Hydrogen Photoproduction Rates and Yields by Wild-Type Algae is Detected at High Photobioreactor Gas Phase Volume (Fact Sheet)

    SciTech Connect

    Not Available

    2012-07-01

    This NREL Hydrogen and Fuel Cell Technical Highlight describes how hydrogen photoproduction activity in algal cultures can be improved dramatically by increasing the gas-phase to liquid-phase volume ratio of the photobioreactor. NREL, in partnership with subcontractors from the Institute of Basic Biological Problems in Pushchino, Russia, demonstrated that the hydrogen photoproduction rate in algal cultures always decreases exponentially with increasing hydrogen partial pressure above the culture. The inhibitory effect of high hydrogen concentrations in the photobioreactor gas phase on hydrogen photoproduction by algae is significant and comparable to the effect observed with some anaerobic bacteria.

  15. Finding of no significant impact: Interim storage of enriched uranium above the maximum historical level at the Y-12 Plant Oak Ridge, Tennessee

    SciTech Connect

    1995-12-01

    The US Department of Energy (DOE) has prepared an Environmental Assessment (EA) for the Proposed Interim Storage of Enriched Uranium Above the Maximum Historical Storage Level at the Y-12 Plant, Oak Ridge, Tennessee (DOE/EA-0929, September, 1994). The EA evaluates the environmental effects of transportation, prestorage processing, and interim storage of bounding quantities of enriched uranium at the Y-12 Plant over a ten-year period. The State of Tennessee and the public participated in public meetings and workshops which were held after a predecisional draft EA was released in February 1994, and after the revised pre-approval EA was issued in September 1994. Comments provided by the State and public have been carefully considered by the Department. As a result of this public process, the Department has determined that the Y-12 Plant-would store no more than 500 metric tons of highly enriched uranium (HEU) and no more than 6 metric tons of low enriched uranium (LEU). The bounding storage quantities analyzed in the pre-approval EA are 500 metric tons of HEU and 7,105.9 metric tons of LEU. Based on-the analyses in the EA, as revised by the attachment to the Finding of No Significant Impact (FONSI), DOE has determined that interim storage of 500 metric tons of HEU and 6 metric tons of LEU at the Y-12 Plant does not constitute a major Federal action significantly affecting the quality of the human environment, within the meaning of the National Environmental Policy Act (NEPA) of 1969. Therefore, an Environmental Impact Statement (EIS) is not required and the Department is issuing this FONSI.

  16. Finding of No Significant Impact for the Environmental Assessment for the Strategic Petroleum Reserve West Hackberry Facility Raw Water Intake Pipeline Replacement Cameron and Calcasieu Parishes, Louisiana

    SciTech Connect

    N /A

    2004-08-31

    DOE has prepared an Environmental Assessment (EA), DOE/EA-1497, for the proposed replacement of the existing 107 centimeter (cm) [42 inch (in)] 6.87 kilometer (km) [4.27 mile (mi)] raw water intake pipeline (RWIPL). This action is necessary to allow for continued, optimum operations at the West Hackberry facility (main site/facility). The EA described the proposed action (including action alternatives) and three alternatives to the proposed action. The EA evaluated only the potential environmental consequences of the proposed action (one action alternative), and Alternative 3, which consisted of the No Build Action that is required by 10 CFR 1021.321(c). Based on the analysis in DOE/EA-1497, DOE has determined that the proposed action does not constitute a major Federal action significantly affecting humans or the natural environment within the meaning of the National Environmental Policy Act of 1969 (NEPA), 42 USC 4321 et seq. Therefore, an Environmental Impact Statement (EIS) is not required, and DOE is issuing this Finding of No Significant Impact (FONSI). To further minimize impacts to environmental media, the DOE will also implement a Mitigation Action Plan (MAP) for this action. The MAP is included as Appendix F of this EA, which is appended to this FONSI. The Energy Policy and Conservation Act of 1975 (EPCA), as amended, authorizes the creation of the Strategic Petroleum Reserve (SPR) to store crude oil to reduce the United States' vulnerability to energy supply disruptions. Crude oil is stored in geologic formations, or salt domes, located under these facilities. The purpose of this proposed project is to construct a new RWIPL at the main site to replace the existing RWIPL which services this facility.

  17. Seropositivity to a major allergen of Anisakis simplex, Ani s 1, in dyspeptic patients with Helicobacter pylori infection: histological and laboratory findings and clinical significance.

    PubMed

    Toro, C; Caballero, M L; Baquero, M; García-Samaniego, J; Casado, I; Martínez, P; Alarcón, T; Moneo, I

    2006-05-01

    Previous studies have demonstrated a high prevalence of seropositivity to the Ani s 1 protein in dyspeptic patients with Helicobacter pylori infection, but it is not known whether this represents episodes of anisakiasis misdiagnosis or previous exposure to the parasite without clinical relevance. To investigate the clinical significance of seropositivity to the Ani s 1 protein, a cohort study was performed with 87 consecutive dyspeptic patients who were treated for H. pylori infection. Fourteen (16.5%) patients were seropositive for the Ani s 1 protein, which was associated with the consumption of uncooked fish (p 0.0002). There were no differences in histological findings between subjects seropositive or seronegative for Ani s 1, but seropositive patients had increased eosinophil and basophil leukocyte counts (p < 0.05). Anti-Ani s 1 IgE was associated with a lack of improvement in the group of patients with non-ulcer dyspepsia after successful eradication of H. pylori (p 0.016). Thus, in at least a subset of patients with H. pylori infection, seropositivity to Ani s 1 could have clinical relevance. In addition, these data highlight that only anisakiasis associated with severe allergic or gastric symptoms is currently being diagnosed. PMID:16643522

  18. Monosomy 1p36.31-33{yields}pter due to a paternal reciprocal translocation: Prognostic significance of FISH analysis

    SciTech Connect

    Blennow, E.; Bui, The-Hung; Wallin, A.

    1996-10-02

    A rare monosomy 1p36.31-33{r_arrow}pter was found in a child with physical anomalies, psycho-motor retardation, and seizures. Cytogenetic investigation suggested an unbalanced translocation between 1p and an acrocentric chromosome, but the rearrangement was difficult to assess accurately using conventional chromosome banding techniques. The half-cryptic translocation was further characterized using fluorescence in situ hybridization, and the aberrant chromosome 1 was shown to be a derivate of a paternal reciprocal translocation t(1;15)(p36.31-33;p11.2-12). The breakpoints on chromosome 1 and 15 were defined in detail using locus specific probes. The rearrangement did not include the region on chromosome 1p which previously has been suggested to predispose to the development of neuroblastoma in a case with a constitutional translocation. At 3 6/12 years, the patient has no clinical signs of this disease, which illustrates the prognostic significance of this investigation. 30 refs., 4 figs., 1 tab.

  19. Genome-wide association study of alcohol dependence:significant findings in African- and European-Americans including novel risk loci.

    PubMed

    Gelernter, J; Kranzler, H R; Sherva, R; Almasy, L; Koesterer, R; Smith, A H; Anton, R; Preuss, U W; Ridinger, M; Rujescu, D; Wodarz, N; Zill, P; Zhao, H; Farrer, L A

    2014-01-01

    We report a GWAS of alcohol dependence (AD) in European-American (EA) and African-American (AA) populations, with replication in independent samples of EAs, AAs and Germans. Our sample for discovery and replication was 16 087 subjects, the largest sample for AD GWAS to date. Numerous genome-wide significant (GWS) associations were identified, many novel. Most associations were population specific, but in several cases were GWS in EAs and AAs for different SNPs at the same locus,showing biological convergence across populations. We confirmed well-known risk loci mapped to alcohol-metabolizing enzyme genes, notably ADH1B (EAs: Arg48His, P=1.17 × 10(-31); AAs: Arg369Cys, P=6.33 × 10(-17)) and ADH1C in AAs (Thr151Thr, P=4.94 × 10(-10)), and identified novel risk loci mapping to the ADH gene cluster on chromosome 4 and extending centromerically beyond it to include GWS associations at LOC100507053 in AAs (P=2.63 × 10(-11)), PDLIM5 in EAs (P=2.01 × 10(-8)), and METAP in AAs (P=3.35 × 10(-8)). We also identified a novel GWS association (1.17 × 10(-10)) mapped to chromosome 2 at rs1437396, between MTIF2 and CCDC88A, across all of the EA and AA cohorts, with supportive gene expression evidence, and population-specific GWS for markers on chromosomes 5, 9 and 19. Several of the novel associations implicate direct involvement of, or interaction with, genes previously identified as schizophrenia risk loci. Confirmation of known AD risk loci supports the overall validity of the study; the novel loci are worthy of genetic and biological follow-up. The findings support a convergence of risk genes (but not necessarily risk alleles) between populations, and, to a lesser extent, between psychiatric traits. PMID:24166409

  20. Environmental Assessment and Finding of No Significant Impact: Interim Measures for the Mixed Waste Management Facility Groundwater at the Burial Ground Complex at the Savannah River Site

    SciTech Connect

    N /A

    1999-12-08

    the southwest plume area to Fourmile Branch between 25 to 35 percent. If this proposed action is undertaken and its effectiveness is demonstrated, it may become a component of the final action in the CAP. This document was prepared in compliance with the National Environmental Policy Act (NEPA) of 1969, as amended; the requirements of the Council on Environmental Quality Regulations for Implementing NEPA (40 CFR 1500-1508); and the DOE Regulations for Implementing NEPA (10 CFR 1021). NEPA requires the assessment of environmental consequences of Federal actions that may affect the quality of the human environment. Based on the potential for impacts described herein, DOE will either publish a Finding of No Significant Impact (FONSI) or prepare an environmental impact statement (EM).

  1. Solid Surface Combustion Experiment Yields Significant Observations

    NASA Technical Reports Server (NTRS)

    Sacksteder, Kurt R.; Koudelka, John M.; Vergilii, Franklin

    1999-01-01

    The spread of a flame over solid fuel is not only a fundamental textbook combustion phenomenon, but also the central element of destructive fires that cause tragic loss of life and property each year. Throughout history, practical measures to prevent and fight fires have been developed, but these have often been based on lessons learned in a costly fire. Since the 1960 s, scientists and engineers have employed powerful tools of scientific research to understand the details of flame spread and how a material can be rendered nonflammable. High-speed computers have enabled complex flame simulations, whereasand lasers have provided measurements of the chemical composition, temperature, and air velocities inside flames. The microgravity environment has emerged as the third great tool for these studies. Spreading flames are complex combinations of chemical reactions and several physical processes including the transport of oxygen and fuel vapor to the flame and the transfer of heat from the flame to fresh fuel and to the surroundings. Depending on its speed, air motion in the vicinity of the flame can affect the flame in substantially different ways. For example, consider the difference between blowing on a campfire and blowing out a match. On Earth, gravity induces air motion because of buoyancy (the familiar rising hot gases); this process cannot be controlled experimentally. For theoreticians, buoyant air motion complicates the problem modeling of flame spread beyond the capacity of modern computers to simulate. The microgravity environment provides experimental control of air motion near spreading flames, with results that can be compared with detailed theory. The Solid Surface Combustion Experiment (SSCE) was designed to obtain benchmark flame spreading data in quiescent test atmospheres--the limiting case of flames spreading. Professor Robert Altenkirch, Vice President for Research at Mississippi State University, proposed the experiment concept, and the NASA Lewis Research Center designed, built, and tested the SSCE hardware. It was the first microgravity science experiment built by Lewis for the space shuttle and the first combustion science experiment flown in space.

  2. Binding screen for cystic fibrosis transmembrane conductance regulator correctors finds new chemical matter and yields insights into cystic fibrosis therapeutic strategy.

    PubMed

    Hall, Justin D; Wang, Hong; Byrnes, Laura J; Shanker, Suman; Wang, Kelong; Efremov, Ivan V; Chong, P Andrew; Forman-Kay, Julie D; Aulabaugh, Ann E

    2016-02-01

    The most common mutation in cystic fibrosis (CF) patients is deletion of F508 (ΔF508) in the first nucleotide binding domain (NBD1) of the CF transmembrane conductance regulator (CFTR). ΔF508 causes a decrease in the trafficking of CFTR to the cell surface and reduces the thermal stability of isolated NBD1; it is well established that both of these effects can be rescued by additional revertant mutations in NBD1. The current paradigm in CF small molecule drug discovery is that, like revertant mutations, a path may exist to ΔF508 CFTR correction through a small molecule chaperone binding to NBD1. We, therefore, set out to find small molecule binders of NBD1 and test whether it is possible to develop these molecules into potent binders that increase CFTR trafficking in CF-patient-derived human bronchial epithelial cells. Several fragments were identified that bind NBD1 at either the CFFT-001 site or the BIA site. However, repeated attempts to improve the affinity of these fragments resulted in only modest gains. Although these results cannot prove that there is no possibility of finding a high-affinity small molecule binder of NBD1, they are discouraging and lead us to hypothesize that the nature of these two binding sites, and isolated NBD1 itself, may not contain the features needed to build high-affinity interactions. Future work in this area may, therefore, require constructs including other domains of CFTR in addition to NBD1, if high-affinity small molecule binding is to be achieved. PMID:26444971

  3. Pursuit of the “truth” about mental illness: the significance of findings in neuropsychiatric research, and lessons from the past

    PubMed Central

    DeLisi, Lynn E.

    2014-01-01

    Technology in genetics and brain imaging has advanced so rapidly that it is difficult to be knowledgeable about all the new tools being used in the pursuit of progress toward understanding and treating mental illness. While findings from new studies remain promising, caution is needed with regard to their current applicability to clinical use, both to predict who is likely to become ill and who is likely to respond to medication. A perspective on the past, using schizophrenia as an example, illustrates important findings that were published, had much visibility, and caused a flurry of new related studies, but then slowly disappeared, either to be abandoned as an artifact of the assay or study design, an epiphenomenon, or as simply nonreplicated findings not leading to further progress. Remembering that good science is “the pursuit of the truth” and not joining the latest “bandwagon fad” of “believers” is an important principle to adhere to when participating in the politics of science. PMID:25733950

  4. From Bayes through Marginal Utility to Effect Sizes: A Guide to Understanding the Clinical and Statistical Significance of the Results of Autism Research Findings

    ERIC Educational Resources Information Center

    Cicchetti, Domenic V.; Koenig, Kathy; Klin, Ami; Volkmar, Fred R.; Paul, Rhea; Sparrow, Sara

    2011-01-01

    The objectives of this report are: (a) to trace the theoretical roots of the concept clinical significance that derives from Bayesian thinking, Marginal Utility/Diminishing Returns in Economics, and the "just noticeable difference", in Psychophysics. These concepts then translated into: Effect Size (ES), strength of agreement, clinical…

  5. Detection of cancer cells and tumor markers in gastric lavage of patients with gastric cancer: Do these findings have a clinicopathological significance and oncological implication?

    PubMed

    Virgilio, Edoardo; Giarnieri, Enrico; Montagnini, Monica; D'Urso, Rosaria; Proietti, Antonella; Mesiti, Alessandra; Giovagnoli, Maria Rosaria; Mercantini, Paolo; Cavallini, Marco; Balducci, Genoveffa

    2016-09-01

    Although decreasing in the incidence over the last years, currently gastric adenocarcinoma represents the second cause of cancer related-death worldwide. Further knowledge and novel therapies are desperately needed in order to make the prognosis of these patients more acceptable. Infact, even though in recent years numerous staging parameters have been largely studied and unanimously recognized for their clinical and prognostic value, today too many shadows still exist around the capacity to predict exactly the natural history or post-treatment behavior of this cancer even among patients of the same stage. This study has identified the presence of isolated cancer cells as well as tumor markers (CEA, Ca 19.9, Ca 72.4 and Ca 50) from the gastric lavage of patients affected by gastric adenocarcinoma. Such findings led to the hypothesis that endoluminal exfoliation of neoplastic cells and the release of their products (tumor markers) into the gastric juice might be an expression of neoplastic behavior as well as aggressive malignancy. Should this hypothesis become a reality, some important progress could be made in the knowledge, staging, prediction as well as management and follow-up of this inauspicious type of cancer. PMID:27515187

  6. Prognostic significance of prevalent and incident atrial fibrillation among patients hospitalized with acute coronary syndrome: findings from the Gulf RACE-2 Registry.

    PubMed

    Hersi, Ahmad; Alhabib, Khalid F; Alsheikh-Ali, Alawi A; Sulaiman, Kadhim; Alfaleh, Hussam F; Alsaif, Shukri; Al-Mahmeed, Wael; Asaad, Nidal; Haitham, Amin; Al-Motarreb, Ahmed; Suwaidi, Jassim; Shehab, Abdullah

    2012-08-01

    There is a paucity of data on atrial fibrillation (AF) complicating acute coronary syndrome (ACS) in Arabian Gulf countries. Thus, we assessed the incidence of AF in patients with ACS in these countries and examined the associated in-hospital, 30-day, and 1-year adverse outcomes. The population comprised 7930 patients enrolled in the second Gulf Registry of Acute Coronary Events (Gulf RACE-2). Of 7930 patients with ACS, 217 (2.7%) had AF. Compared with patients without AF, patients with AF were less likely to be male (65.9 vs 79.1%) and were older (mean age 64.6 vs 56.6 years). Compared with patients without AF, in-hospital, 30-day, and 1-year mortality were significantly higher in patients with any AF (odds ratio [OR]: 2.7, 2.2, 1.9, respectively; P < .001) and in patients with new-onset AF (OR: 5.2, 3.9, 3.1, respectively; P < .001. In conclusion, AF in patients with ACS was associated with significantly higher short- and long-term mortality. PMID:22144666

  7. Environmental Assessment and Finding of No Significant Impact: Expansion of the Volpentest Hazardous Materials Management and Emergency Response Training and Education Center, Hanford Site, Richland, Washington

    SciTech Connect

    N /A

    2002-11-06

    The U.S. Department of Energy needs to provide additional cost-effective personal protection and public safety through expanding training and equipment testing facilities at the Volpentest Hazardous Materials Management and Emergency Response Training and Education Center (HAMMER) on the Hanford Site. The U.S. Department of Energy (DOE) has prepared an Environmental Assessment (EA), DOE/EA-1412, for expanding training and equipment testing facilities at the Volpentest Hazardous Materials Management and Emergency Response Training and Education Center (HAMMER) on the Hanford Site, Richland, Washington. Based on the analysis in the EA, and considering tribal and agency comments, DOE has determined that the proposed action is not a major federal action significantly affecting the quality of the human environment within the meaning of the ''National Environmental Policy Act of 1969'' (NEPA). Therefore, the preparation of an Environmental Impact Statement (EIS) is not required.

  8. Environmental Assessment and Finding of No Significant Impact: Curecanti-Lost Canyon 230-kV Transmission Line Reroute Project, Montrose County, Colorado

    SciTech Connect

    N /A

    2000-03-20

    The Department of Energy (DOE), Western Area Power Administration (Western) is proposing to reroute a section of the Curecanti-Lost Canyon 230-kilovolt (kV) transmission line, in Montrose County, Colorado. A portion of the transmission line, situated 11 miles southeast of Montrose, Colorado, crosses Waterdog Peak, an area of significant geologic surface activity, which is causing the transmission line's lattice steel towers to shift. This increases stress to structure hardware and conductors, and poses a threat to the integrity of the transmission system. Western proposes to relocate the lattice steel towers and line to a more geologically stable area. The existing section of transmission line and the proposed relocation route cross Bureau of Land Management and private land holdings.

  9. Changes in Normal Liver and Spleen Volume after Radioembolization with {sup 90}Y-Resin Microspheres in Metastatic Breast Cancer Patients: Findings and Clinical Significance

    SciTech Connect

    Paprottka, Philipp M. Schmidt, G. P.; Trumm, C. G.; Hoffmann, R. T.; Reiser, M. F.; Jakobs, T. F.

    2011-10-15

    Purpose: In clinical trials with yttrium-90-resin-microspheres for the management of colorectal cancer liver metastases, it was observed that radioembolization might result in splenomegaly and an increase in portal vein size. Subclinical hepatitis in normal liver tissue as well as the effects of radioembolization and prior chemotherapy are suspected to be responsible for this phenomenon. The purpose of this study was to quantify the changes in liver and spleen volume and portal vein diameter after radioembolization. Methods: Twenty-seven patients with liver-dominant metastatic disease from breast cancer who had not responded to chemotherapy or had to abandon chemotherapy because of its toxic effects were evaluated. Changes in liver and spleen volume and portal vein diameter as well as liver tumor volume and diameter were quantified using computed tomography scans. Results: Radioembolization was associated with a significant mean decrease in the whole liver volume of 10.2% (median 16.7%; P = 0.0024), mainly caused by a reduction in the right lobe volume (mean 16.0%; P < 0.0001). These changes were accompanied by a significant increase in the diameter of the main portal vein (mean 6.8%; P < 0.0001) as well as splenic volume (mean 50.4%; P < 0.0001). Liver-tumor volume and diameter decreased by a median of 24 and 39.7%. Conclusions: Radioembolization is an effective treatment for tumor size reduction in patients with breast cancer liver metastases. Treatment is associated with changes of hepatic parenchymal volume, splenic volume, and portal vein size that appear not to represent clinically important sequelae in this patient cohort.

  10. Significant Findings: Tracking the SeaWiFS Record with a Coupled Physical/Biogeochemical/Radiative Model of the Global Oceans

    NASA Technical Reports Server (NTRS)

    Watson, Gregg W.

    2000-01-01

    The Sea-Viewing Wide Field-of-view Sensor (SeaWiFS) has observed 2.5 years of routine global chlorophyll observations from space. The mission was launched into a record El Nino event, which eventually gave way to one of the most intensive and longest-lasting La Nina events ever recorded. The SeaWiFS chlorophyll record captured the response of ocean phytoplankton to these significant events in the tropical Indo-Pacific basins, but also indicated significant interannual variability unrelated to the El Nino/La Nina events. This included large variability in the North Atlantic and Pacific basins, in the North Central and equatorial Atlantic, and milder patterns in the North Central Pacific. This SeaWiFS record was tracked with a coupled physical/biogeochemical/radiative model of the global oceans using near-real-time forcing data such as wind stresses, sea surface temperatures, and sea ice. This provided an opportunity to offer physically and biogeochemically meaningful explanations of the variability observed in the SeaWiFS data set, since the causal mechanisms and interrelationships of the model are completely understood. The coupled model was able to represent the seasonal distributions of chlorophyll during the SeaWiFS era, and was capable of differentiating among the widely different processes and dynamics occurring in the global oceans. The model was also reasonably successful in representing the interannual signal, especially when it was large, such as, the El Nino and La Nina events in the tropical Pacific and Indian Oceans. The model provided different phytoplankton group responses for the different events in these regions: diatoms were predominant in the tropical Pacific during the La Nina but other groups were predominant during El Nino. The opposite condition occurred in the tropical Indian Ocean. Both situations were due to the different responses of the basins to El Nino. The interannual variability in the North Atlantic, which was exhibited in Sea

  11. Optical Measurement Technologies for High Temperature, Radiation Exposure, and Corrosive Environments—Significant Activities and Findings: In-vessel Optical Measurements for Advanced SMRs

    SciTech Connect

    Anheier, Norman C.; Cannon, Bret D.; Qiao, Hong; Suter, Jonathan D.

    2012-09-01

    Development of advanced Small Modular Reactors (aSMRs) is key to providing the United States with a sustainable, economically viable, and carbon-neutral energy source. The aSMR designs have attractive economic factors that should compensate for the economies of scale that have driven development of large commercial nuclear power plants to date. For example, aSMRs can be manufactured at reduced capital costs in a factory and potentially shorter lead times and then be shipped to a site to provide power away from large grid systems. The integral, self-contained nature of aSMR designs is fundamentally different than conventional reactor designs. Future aSMR deployment will require new instrumentation and control (I&C) architectures to accommodate the integral design and withstand the extreme in-vessel environmental conditions. Operators will depend on sophisticated sensing and machine vision technologies that provide efficient human-machine interface for in-vessel telepresence, telerobotic control, and remote process operations. The future viability of aSMRs is dependent on understanding and overcoming the significant technical challenges involving in-vessel reactor sensing and monitoring under extreme temperatures, pressures, corrosive environments, and radiation fluxes

  12. Environmental Assessment and Finding of No Significant Impact: Wastewater Treatment Capability Upgrade, Project NO. 96-D-122 Pantex Plant Amarillo, Texas

    SciTech Connect

    N /A

    1999-05-27

    that the following conditions are not present, nor of concern at the proposed site on Pantex Plant, and no further analysis was conducted: (1) State or national parks, forests, or other conservation areas; (2) Wild and scenic rivers; (3) Natural resources, such as timber, range, soils, minerals; (4) Properties of historic, archeological, or architectural significance; (5) Native American concerns; (6) Minority and low-income populations; and (7) Prime or unique farmland. In this document, DOE describes the proposed action and a reasonable range of alternatives to the proposed action, including the ''No-Action'' alternative. The proposed action cited in the ''U.S. Department of Energy Application for a Texas Pollutant Discharge Elimination System Permit Modifying Permit to Dispose of Waste, No. 02296,'' December 1998, included the construction of a new wastewater treatment facility, a new irrigation storage pond, and the conversion of the current wastewater treatment facility into an irrigation storage pond. Although a permit modification application has been filed, if a decision on this EA necessitates it, an amendment to the permit application would be made. The permit application would be required for any of the alternatives and the filing does not preclude or predetermine selection of an alternative considered by this EA. This permit change would allow Pantex to land-dispose treated wastewater by irrigating agricultural land. This construction for the proposed action would include designing two new lagoons for wastewater treatment. One of the lagoons could function as a facultative lagoon for treatment of wastewater. The second lagoon would serve as an irrigation storage impoundment (storage pond), with the alternative use as a facultative lagoon if the first lagoon is out of service for any reason. The new facultative lagoon and irrigation water storage pond would be sited outside of the 100-year flood plain. The existing WWTF lagoon would be used as a storage pond

  13. Final Environmental Assessment and Finding of No Significant Impact: Construction and Operation of the Molecular Foundry at Ernest Orlando Lawrence Berkeley National Laboratory Berkeley, California

    SciTech Connect

    N /A

    2003-03-07

    Nanotechnology Initiative (NNI). Nanotechnology is the design, fabrication, characterization, and use of materials, devices, and systems through the control of matter at the nanometer-length scale. Nanoscience will develop the understanding of building blocks at the nanometer-length scale and the methods by which they are assembled into multi-component devices. Alternatives to the Proposed Action include a reduced size building configuration, location of the building on a different on-site location, and a No Action alternative. Several off-site alternatives were considered but were not found to reasonably meet the purpose and need for the Proposed Action. Of the reasonable alternatives analyzed, the Proposed Action is found to best meet DOE's purpose and need for action. Although the Proposed Action would take place on a partially developed site that is generally surrounded by existing buildings and roads, the site is near to designated Critical Habitat of the Federally-listed Alameda Whipsnake. To minimize any potential but unexpected impact to the Alameda whipsnake, several mitigation measures are proposed. In addition, the Proposed Action would result in minor increases in stormwater runoff, air pollutant emissions, visual quality impacts, noise impacts, and the potential to disturb unanticipated archaeological resources. It would produce marginal increases in traffic and parking demand, as well as incremental demand increases for water, energy, wastewater treatment, waste disposal, and public services. The following impact is found to be potentially significant without mitigation in this Environmental Assessment: Although the site is not located in USFWS-designated critical habitat, due to the potential for Alameda whipsnake movement into the project area, mitigation measures would be implemented to ensure that whipsnakes are protected to the greatest extent possible during project construction.

  14. Novel Cell-Ess ® supplement used as a feed or as an initial boost to CHO serum free media results in a significant increase in protein yield and production.

    PubMed

    Elhofy, Adam

    2016-01-01

    Many metrics, including metabolic profiles, have been used to analyze cell health and optimize productivity. In this study, we investigated the ability of a lipid supplement to increase protein yield. At a concentration of 1% (v/v) the lipid supplement caused a significant increase in protein titer (1118 ± 65.4 ng 10(5) cells(- 1) days(- 1)) when compared to cultures grown in the absence of supplementation (819.3 ± 38.1 ng 10(5) cells(- 1) days(- 1); p < 0.05). This equated to a 37% increase in productivity. Furthermore, metabolic profiles of ammonia, glutamate, lactate, and glucose were not significantly altered by the polar lipid supplement. In a separate set of experiments, using the supplement as a feed resulted in 2 notable effects. The first was a 25% increase in protein titer. The second was an extension of peak protein production from 1 day to 2 days. These results suggest that lipid supplementation is a promising avenue for enhancing protein production. In addition, our results also suggest that an increase in protein production may not necessarily require a change in the metabolic state of the cells. PMID:27594979

  15. Finding of no significant impact shipment of stabilized mixed waste from the K-25 Site to an off-site commercial disposal facility, Oak Ridge K-25 Site, Oak Ridge, Tennessee

    SciTech Connect

    1994-12-31

    The Department of Energy (DOE) has prepared an Environmental Assessment (EA) for the shipment of stabilized mixed waste, removed from K-1407-B and -C ponds, to an off-site commercial disposal facility (Envirocare) for permanent land disposal. Based on the analysis in the EA, DOE has determined that the proposed action is not a major federal action significantly affecting the quality of the human environment, within the meaning of the National Environmental Policy Act (NEPA) of 1969. Therefore, the preparation of an environmental impact statement (EIS) is not required, and DOE is issuing this Finding of No Significant Impact (FONSI).

  16. Helicobacter pylori infection has no impact on manometric and pH-metric findings in adolescents and young adults with gastroesophageal reflux and antral gastritis: eradication results to no significant clinical improvement

    PubMed Central

    Xinias, Ioannis; Maris, Theophanis; Mavroudi, Antigoni; Panteliadis, Christos; Vandenplas, Yvan

    2013-01-01

    The relationship between Helicobacter pylori (Hp) gastritis and gastroesophageal reflux disease (GERD) remains controversial. The aim was to investigate the association between Hp infection and gastroesophageal reflux (GER) and the impact of Hp eradication on esophageal acid exposure and motility in adolescents and young adults with Hp gastritis and GERD. Sixty-four patients with symptoms suggestive for GERD, of which 40 Hp-positive (group A) and 24 Hp-negative (group B), underwent endoscopy-biopsy, esophageal manometry and 24-hour pH-metry. All group A patients received eradication treatment and were re-evaluated six months later again with 24-hour pH-metry, esophageal manometry, endoscopy-biopsy and clinical assessment. At inclusion, there were no significant differences between the two groups regarding sex, age, grade of endoscopic esophagitis, manometric and pH-metry findings. All Hp-positive patients had an antral predominant gastritis. Eradication of Hp was successful in all patients, and gastritis and esophagitis were healed in all patients. The mean lower esophageal sphincter pressure (LESP) increased significantly from 11.25 mmHg before to 11.71 mmHg after eradication (P<0.05). A significant decrease in reflux index was observed (mean RI 6.02% before versus 4.96% after eradication (P<0.05). However clinical symptoms of GER improved not significantly after 6 months follow up. Conclusively, in children and young adults with GER symptoms and GERD, the presence or absence of Hp has no impact on manometric and pH-metric findings. Eradication of Hp infection results in increase in LESP with a consequent decrease in esophageal acid exposure but not significant clinical improvement. PMID:23667732

  17. Finding of No Significant Impact and Final Environmental Assessment for the Future Location of Heat Source/Radioisotope Power System Assembly and Testing and Operations Currently Located at the Mound Site

    SciTech Connect

    N /A

    2002-08-30

    The U.S. Department of Energy (the Department) has completed an Environmental Assessment for the Future Location of the Heat Source/Radioisotope Power System Assembly and Test. Operations Currently Located at the Mound Site. Based on the analysis in the environmental assessment, the Department has determined that the proposed action, the relocation of the Department's heat source and radioisotope power system operations, does not constitute a major Federal action significantly affecting the quality of the human environment within the meaning of the ''National Environmental Policy Act'' of 1969 (NEPA). Therefore, the preparation of an Environmental Impact Statement is not required, and the Department is issuing this Finding of No Significant Impact (FONSI).

  18. Final Environmental Assessment and Finding of No Significant Impact: The Implementation of the Authorized Limits Process for Waste Acceptance at the C-746-U Landfill Paducah Gaseous Diffusion Plant Paducah, Kentucky

    SciTech Connect

    N /A

    2002-08-06

    The US Department of Energy (DOE) has completed an environmental assessment (DOE/EA-1414) for the proposed implementation of the authorized limits process for waste acceptance at the C-746-U Landfill at the Paducah Gaseous Diffusion Plant (PGDP) in Paducah, Kentucky. Based on the results of the impact analysis reported in the EA, which is incorporated herein by this reference, DOE has determined that the proposed action is not a major Federal action that would significantly affect the quality of the human environment within the context of the ''National Environmental Policy Act of 1969'' (NEPA). Therefore preparation of an environmental impact statement is not necessary, and DOE is issuing this Finding of No Significant Impact (FONSI).

  19. Flood-tolerant rice reduces yield variability and raises expected yield, differentially benefitting socially disadvantaged groups

    PubMed Central

    Dar, Manzoor H.; de Janvry, Alain; Emerick, Kyle; Raitzer, David; Sadoulet, Elisabeth

    2013-01-01

    Approximately 30% of the cultivated rice area in India is prone to crop damage from prolonged flooding. We use a randomized field experiment in 128 villages of Orissa India to show that Swarna-Sub1, a recently released submergence-tolerant rice variety, has significant positive impacts on rice yield when fields are submerged for 7 to 14 days with no yield penalty without flooding. We estimate that Swarna-Sub1 offers an approximate 45% increase in yields over the current popular variety when fields are submerged for 10 days. We show additionally that low-lying areas prone to flooding tend to be more heavily occupied by people belonging to lower caste social groups. Thus, a policy relevant implication of our findings is that flood-tolerant rice can deliver both efficiency gains, through reduced yield variability and higher expected yield, and equity gains in disproportionately benefiting the most marginal group of farmers. PMID:24263095

  20. How to Use SNP_TATA_Comparator to Find a Significant Change in Gene Expression Caused by the Regulatory SNP of This Gene's Promoter via a Change in Affinity of the TATA-Binding Protein for This Promoter

    PubMed Central

    Ponomarenko, Mikhail; Rasskazov, Dmitry; Arkova, Olga; Ponomarenko, Petr; Suslov, Valentin; Savinkova, Ludmila; Kolchanov, Nikolay

    2015-01-01

    The use of biomedical SNP markers of diseases can improve effectiveness of treatment. Genotyping of patients with subsequent searching for SNPs more frequent than in norm is the only commonly accepted method for identification of SNP markers within the framework of translational research. The bioinformatics applications aimed at millions of unannotated SNPs of the “1000 Genomes” can make this search for SNP markers more focused and less expensive. We used our Web service involving Fisher's Z-score for candidate SNP markers to find a significant change in a gene's expression. Here we analyzed the change caused by SNPs in the gene's promoter via a change in affinity of the TATA-binding protein for this promoter. We provide examples and discuss how to use this bioinformatics application in the course of practical analysis of unannotated SNPs from the “1000 Genomes” project. Using known biomedical SNP markers, we identified 17 novel candidate SNP markers nearby: rs549858786 (rheumatoid arthritis); rs72661131 (cardiovascular events in rheumatoid arthritis); rs562962093 (stroke); rs563558831 (cyclophosphamide bioactivation); rs55878706 (malaria resistance, leukopenia), rs572527200 (asthma, systemic sclerosis, and psoriasis), rs371045754 (hemophilia B), rs587745372 (cardiovascular events); rs372329931, rs200209906, rs367732974, and rs549591993 (all four: cancer); rs17231520 and rs569033466 (both: atherosclerosis); rs63750953, rs281864525, and rs34166473 (all three: malaria resistance, thalassemia). PMID:26516624

  1. Prevalence of defined ultrasound findings of unknown significance at the second trimester fetal anomaly scan and their association with adverse pregnancy outcomes: the Welsh study of mothers and babies population‐based cohort

    PubMed Central

    Hurt, Lisa; Wright, Melissa; Dunstan, Frank; Thomas, Susan; Brook, Fiona; Morris, Susan; Tucker, David; Wills, Marilyn Ann; Davies, Colin; John, Gareth; Fone, David

    2015-01-01

    Abstract Objective The aim of this article was to estimate the population prevalence of seven defined ultrasound findings of uncertain significance (‘markers’) in the second trimester and the associated risk of adverse pregnancy outcomes. Method A prospective record‐linked cohort study of 30 078 pregnant women who had second trimester anomaly scans between July 2008 and March 2011 in Wales was conducted. Results The prevalence of markers ranged from 43.7 per 1000 singleton pregnancies for cardiac echogenic foci [95% confidence interval (CI): 38.8, 51.1] to 0.6 for mild‐to‐moderate ventriculomegaly (95% CI: 0.3, 1.0). Isolated echogenic bowel was associated with an increased risk of congenital anomalies [risk ratio (RR) 4.54, 95% CI: 2.12, 9.73] and preterm birth (RR 2.30, 95% CI: 1.08, 4.90). Isolated pelvicalyceal dilatation was associated with an increased risk of congenital anomalies (RR 3.82, 95% CI: 2.16, 6.77). Multiple markers were associated with an increased risk of congenital anomalies (RR 5.00, 95% CI: 1.35, 18.40) and preterm birth (RR 3.38, 95% CI 1.20, 9.53). Conclusions These data are useful for counselling families and developing clinical guidance and care pathways following the detection of markers in clinical practice, particularly the need for follow‐up scans to monitor placental function and growth in pregnancies with isolated echogenic bowel, and further investigation for multiple markers. © 2015 The Authors. Prenatal Diagnosis published by John Wiley & Sons Ltd. PMID:26475362

  2. Finding food

    PubMed Central

    Forsyth, Ann; Lytle, Leslie; Riper, David Van

    2011-01-01

    A significant amount of travel is undertaken to find food. This paper examines challenges in measuring access to food using Geographic Information Systems (GIS), important in studies of both travel and eating behavior. It compares different sources of data available including fieldwork, land use and parcel data, licensing information, commercial listings, taxation data, and online street-level photographs. It proposes methods to classify different kinds of food sales places in a way that says something about their potential for delivering healthy food options. In assessing the relationship between food access and travel behavior, analysts must clearly conceptualize key variables, document measurement processes, and be clear about the strengths and weaknesses of data. PMID:21837264

  3. Significant Treasures.

    ERIC Educational Resources Information Center

    Andrews, Ian A.

    1999-01-01

    Provides a crossword puzzle with an answer key corresponding to the book entitled "Significant Treasures/Tresors Parlants" that is filled with color and black-and-white prints of paintings and artifacts from 131 museums and art galleries as a sampling of the 2,200 such Canadian institutions. (CMK)

  4. Maximizing the ExoEarth candidate yield from a future direct imaging mission

    SciTech Connect

    Stark, Christopher C.; Roberge, Aki; Mandell, Avi; Robinson, Tyler D.

    2014-11-10

    ExoEarth yield is a critical science metric for future exoplanet imaging missions. Here we estimate exoEarth candidate yield using single visit completeness for a variety of mission design and astrophysical parameters. We review the methods used in previous yield calculations and show that the method choice can significantly impact yield estimates as well as how the yield responds to mission parameters. We introduce a method, called Altruistic Yield Optimization, that optimizes the target list and exposure times to maximize mission yield, adapts maximally to changes in mission parameters, and increases exoEarth candidate yield by up to 100% compared to previous methods. We use Altruistic Yield Optimization to estimate exoEarth candidate yield for a large suite of mission and astrophysical parameters using single visit completeness. We find that exoEarth candidate yield is most sensitive to telescope diameter, followed by coronagraph inner working angle, followed by coronagraph contrast, and finally coronagraph contrast noise floor. We find a surprisingly weak dependence of exoEarth candidate yield on exozodi level. Additionally, we provide a quantitative approach to defining a yield goal for future exoEarth-imaging missions.

  5. Rock Finding

    ERIC Educational Resources Information Center

    Rommel-Esham, Katie; Constable, Susan D.

    2006-01-01

    In this article, the authors discuss a literature-based activity that helps students discover the importance of making detailed observations. In an inspiring children's classic book, "Everybody Needs a Rock" by Byrd Baylor (1974), the author invites readers to go "rock finding," laying out 10 rules for finding a "perfect" rock. In this way, the…

  6. Studies of acute and chronic radiation injury at the Biological and Medical Research Division, Argonne National Laboratory, 1953-1970: Description of individual studies, data files, codes, and summaries of significant findings

    SciTech Connect

    Grahn, D.; Fox, C.; Wright, B.J.; Carnes, B.A.

    1994-05-01

    Between 1953 and 1970, studies on the long-term effects of external x-ray and {gamma} irradiation on inbred and hybrid mouse stocks were carried out at the Biological and Medical Research Division, Argonne National Laboratory. The results of these studies, plus the mating, litter, and pre-experimental stock records, were routinely coded on IBM cards for statistical analysis and record maintenance. Also retained were the survival data from studies performed in the period 1943-1953 at the National Cancer Institute, National Institutes of Health, Bethesda, Maryland. The card-image data files have been corrected where necessary and refiled on hard disks for long-term storage and ease of accessibility. In this report, the individual studies and data files are described, and pertinent factors regarding caging, husbandry, radiation procedures, choice of animals, and other logistical details are summarized. Some of the findings are also presented. Descriptions of the different mouse stocks and hybrids are included in an appendix; more than three dozen stocks were involved in these studies. Two other appendices detail the data files in their original card-image format and the numerical codes used to describe the animal`s exit from an experiment and, for some studies, any associated pathologic findings. Tabular summaries of sample sizes, dose levels, and other variables are also given to assist investigators in their selection of data for analysis. The archive is open to any investigator with legitimate interests and a willingness to collaborate and acknowledge the source of the data and to recognize appropriate conditions or caveats.

  7. Incorporating phenology into yield models

    NASA Astrophysics Data System (ADS)

    Gray, J. M.; Friedl, M. A.

    2015-12-01

    Because the yields of many crops are sensitive to meteorological forcing during specific growth stages, phenological information has potential utility in yield mapping and forecasting exercises. However, most attempts to explain the spatiotemporal variability in crop yields with weather data have relied on growth stage definitions that do not change from year-to-year, even though planting, maturity, and harvesting dates show significant interannual variability. We tested the hypothesis that quantifying temperature exposures over dynamically determined growth stages would better explain observed spatiotemporal variability in crop yields than statically defined time periods. Specifically, we used National Agricultural and Statistics Service (NASS) crop progress data to identify the timing of the start of the maize reproductive growth stage ("silking"), and examined the correlation between county-scale yield anomalies and temperature exposures during either the annual or long-term average silking period. Consistent with our hypothesis and physical understanding, yield anomalies were more correlated with temperature exposures during the actual, rather than the long-term average, silking period. Nevertheless, temperature exposures alone explained a relatively low proportion of the yield variability, indicating that other factors and/or time periods are also important. We next investigated the potential of using remotely sensed land surface phenology instead of NASS progress data to retrieve crop growth stages, but encountered challenges related to crop type mapping and subpixel crop heterogeneity. Here, we discuss the potential of overcoming these challenges and the general utility of remotely sensed land surface phenology in crop yield mapping.

  8. Grapevine canopy reflectance and yield

    NASA Technical Reports Server (NTRS)

    Minden, K. A.; Philipson, W. R.

    1982-01-01

    Field spectroradiometric and airborne multispectral scanner data were applied in a study of Concord grapevines. Spectroradiometric measurements of 18 experimental vines were collected on three dates during one growing season. Spectral reflectance, determined at 30 intervals from 0.4 to 1.1 microns, was correlated with vine yield, pruning weight, clusters/vine, and nitrogen input. One date of airborne multispectral scanner data (11 channels) was collected over commercial vineyards, and the average radiance values for eight vineyard sections were correlated with the corresponding average yields. Although some correlations were significant, they were inadequate for developing a reliable yield prediction model.

  9. Age matters in the prevalence and clinical significance of ultra-high-risk for psychosis symptoms and criteria in the general population: Findings from the BEAR and BEARS-kid studies

    PubMed Central

    Schimmelmann, Benno G; Michel, Chantal; Martz-Irngartinger, Alexandra; Linder, Caroline; Schultze-Lutter, Frauke

    2015-01-01

    Early detection of psychosis is an important topic in psychiatry. Yet, there is limited information on the prevalence and clinical significance of high-risk symptoms in children and adolescents as compared to adults. We examined ultra-high-risk (UHR) symptoms and criteria in a sample of individuals aged 8-40 years from the general population of Canton Bern, Switzerland, enrolled from June 2011 to May 2014. The current presence of attenuated psychotic symptoms (APS) and brief intermittent psychotic symptoms (BLIPS) and the fulfillment of onset/worsening and frequency requirements for these symptoms in UHR criteria were assessed using the Structured Interview for Psychosis Risk Syndromes. Additionally, perceptive and non-perceptive APS were differentiated. Psychosocial functioning and current non-psychotic DSM-IV axis I disorders were also surveyed. Well-trained psychologists performed assessments. Altogether, 9.9% of subjects reported APS and none BLIPS, and 1.3% met all the UHR requirements for APS. APS were related to more current axis I disorders and impaired psychosocial functioning, indicating some clinical significance. A strong age effect was detected around age 16: compared to older individuals, 8-15-year olds reported more perceptive APS, that is, unusual perceptual experiences and attenuated hallucinations. Perceptive APS were generally less related to functional impairment, regardless of age. Conversely, non-perceptive APS were related to low functioning, although this relationship was weaker in those below age 16. Future studies should address the differential effects of perceptive and non-perceptive APS, and their interaction with age, also in terms of conversion to psychosis. PMID:26043337

  10. Ethiopian Wheat Yield and Yield Gap Estimation: A Spatial Small Area Integrated Data Approach

    NASA Astrophysics Data System (ADS)

    Mann, M.; Warner, J.

    2015-12-01

    Despite the collection of routine annual agricultural surveys and significant advances in GIS and remote sensing products, little econometric research has been undertaken in predicting developing nation's agricultural yields. In this paper, we explore the determinants of wheat output per hectare in Ethiopia during the 2011-2013 Meher crop seasons aggregated to the woreda administrative area. Using a panel data approach, combining national agricultural field surveys with relevant GIS and remote sensing products, the model explains nearly 40% of the total variation in wheat output per hectare across the country. The model also identifies specific contributors to wheat yields that include farm management techniques (eg. area planted, improved seed, fertilizer, irrigation), weather (eg. rainfall), water availability (vegetation and moisture deficit indexes) and policy intervention. Our findings suggest that woredas produce between 9.8 and 86.5% of their potential wheat output per hectare given their altitude, weather conditions, terrain, and plant health. At the median, Amhara, Oromiya, SNNP, and Tigray produce 48.6, 51.5, 49.7, and 61.3% of their local attainable yields, respectively. This research has a broad range of applications, especially from a public policy perspective: identifying causes of yield fluctuations, remotely evaluating larger agricultural intervention packages, and analyzing relative yield potential. Overall, the combination of field surveys with spatial data can be used to identify management priorities for improving production at a variety of administrative levels.

  11. Statistical or biological significance?

    PubMed

    Saxon, Emma

    2015-01-01

    Oat plants grown at an agricultural research facility produce higher yields in Field 1 than in Field 2, under well fertilised conditions and with similar weather exposure; all oat plants in both fields are healthy and show no sign of disease. In this study, the authors hypothesised that the soil microbial community might be different in each field, and these differences might explain the difference in oat plant growth. They carried out a metagenomic analysis of the 16 s ribosomal 'signature' sequences from bacteria in 50 randomly located soil samples in each field to determine the composition of the bacterial community. The study identified >1000 species, most of which were present in both fields. The authors identified two plant growth-promoting species that were significantly reduced in soil from Field 2 (Student's t-test P < 0.05), and concluded that these species might have contributed to reduced yield. PMID:26541972

  12. Decomposing global crop yield variability

    NASA Astrophysics Data System (ADS)

    Ben-Ari, Tamara; Makowski, David

    2014-11-01

    Recent food crises have highlighted the need to better understand the between-year variability of agricultural production. Although increasing future production seems necessary, the globalization of commodity markets suggests that the food system would also benefit from enhanced supplies stability through a reduction in the year-to-year variability. Here, we develop an analytical expression decomposing global crop yield interannual variability into three informative components that quantify how evenly are croplands distributed in the world, the proportion of cultivated areas allocated to regions of above or below average variability and the covariation between yields in distinct world regions. This decomposition is used to identify drivers of interannual yield variations for four major crops (i.e., maize, rice, soybean and wheat) over the period 1961-2012. We show that maize production is fairly spread but marked by one prominent region with high levels of crop yield interannual variability (which encompasses the North American corn belt in the USA, and Canada). In contrast, global rice yields have a small variability because, although spatially concentrated, much of the production is located in regions of below-average variability (i.e., South, Eastern and South Eastern Asia). Because of these contrasted land use allocations, an even cultivated land distribution across regions would reduce global maize yield variance, but increase the variance of global yield rice. Intermediate results are obtained for soybean and wheat for which croplands are mainly located in regions with close-to-average variability. At the scale of large world regions, we find that covariances of regional yields have a negligible contribution to global yield variance. The proposed decomposition could be applied at any spatial and time scales, including the yearly time step. By addressing global crop production stability (or lack thereof) our results contribute to the understanding of a key

  13. Child Find

    ERIC Educational Resources Information Center

    Arizona Department of Education, 2006

    2006-01-01

    This brochure describes "Child Find," a component of the Individuals with Disabilities Education Act (IDEA) that requires states to identify, locate, and evaluate all children with disabilities, aged birth through 21, who are in need of early intervention or special education services.

  14. Soybean yield in relation to distance from the Itaipu reservoir

    NASA Astrophysics Data System (ADS)

    de Faria, Rogério Teixeira; Junior, Ruy Casão; Werner, Simone Silmara; Junior, Luiz Antônio Zanão; Hoogenboom, Gerrit

    2016-07-01

    Crops close to small water bodies may exhibit changes in yield if the water mass causes significant changes in the microclimate of areas near the reservoir shoreline. The scientific literature describes this effect as occurring gradually, with higher intensity in the sites near the shoreline and decreasing intensity with distance from the reservoir. Experiments with two soybean cultivars were conducted during four crop seasons to evaluate soybean yield in relation to distance from the Itaipu reservoir and determine the effect of air temperature and water availability on soybean crop yield. Fifteen experimental sites were distributed in three transects perpendicular to the Itaipu reservoir, covering an area at approximately 10 km from the shoreline. The yield gradient between the site closest to the reservoir and the sites farther away in each transect did not show a consistent trend, but varied as a function of distance, crop season, and cultivar. This finding indicates that the Itaipu reservoir does not affect the yield of soybean plants grown within approximately 10 km from the shoreline. In addition, the variation in yield among the experimental sites was not attributed to thermal conditions because the temperature was similar within transects. However, the crop water availability was responsible for higher differences in yield among the neighboring experimental sites related to water stress caused by spatial variability in rainfall, especially during the soybean reproductive period in January and February.

  15. Soybean yield in relation to distance from the Itaipu reservoir

    NASA Astrophysics Data System (ADS)

    de Faria, Rogério Teixeira; Junior, Ruy Casão; Werner, Simone Silmara; Junior, Luiz Antônio Zanão; Hoogenboom, Gerrit

    2015-11-01

    Crops close to small water bodies may exhibit changes in yield if the water mass causes significant changes in the microclimate of areas near the reservoir shoreline. The scientific literature describes this effect as occurring gradually, with higher intensity in the sites near the shoreline and decreasing intensity with distance from the reservoir. Experiments with two soybean cultivars were conducted during four crop seasons to evaluate soybean yield in relation to distance from the Itaipu reservoir and determine the effect of air temperature and water availability on soybean crop yield. Fifteen experimental sites were distributed in three transects perpendicular to the Itaipu reservoir, covering an area at approximately 10 km from the shoreline. The yield gradient between the site closest to the reservoir and the sites farther away in each transect did not show a consistent trend, but varied as a function of distance, crop season, and cultivar. This finding indicates that the Itaipu reservoir does not affect the yield of soybean plants grown within approximately 10 km from the shoreline. In addition, the variation in yield among the experimental sites was not attributed to thermal conditions because the temperature was similar within transects. However, the crop water availability was responsible for higher differences in yield among the neighboring experimental sites related to water stress caused by spatial variability in rainfall, especially during the soybean reproductive period in January and February.

  16. Assessing the impacts of current and future concentrations of surface ozone on crop yield with meta-analysis

    NASA Astrophysics Data System (ADS)

    Feng, Zhaozhong; Kobayashi, Kazuhiko

    Meta-analysis was conducted to quantitatively assess the effects of rising ozone concentrations ([O 3]) on yield and yield components of major food crops: potato, barley, wheat, rice, bean and soybean in 406 experimental observations. Yield loss of the crops under current and future [O 3] was expressed relative to the yield under base [O 3] (≤26 ppb). With potato, current [O 3] (31-50 ppb) reduced the yield by 5.3%, and it reduced the yield of barley, wheat and rice by 8.9%, 9.7% and 17.5%, respectively. In bean and soybean, the yield losses were 19.0% and 7.7%, respectively. Compared with yield loss at current [O 3], future [O 3] (51-75 ppb) drove a further 10% loss in yield of soybean, wheat and rice, and 20% loss in bean. Mass of individual grain, seed, or tuber was often the major cause of the yield loss at current and future [O 3], whereas other yield components also contributed to the yield loss in some cases. No significant difference was found between the responses in crops grown in pots and those in the ground for any yield parameters. The ameliorating effect of elevated [CO 2] was significant in the yields of wheat and potato, and the individual grain weight in wheat exposed to future [O 3]. These findings confirm the rising [O 3] as a threat to food security for the growing global population in this century.

  17. 21 CFR 25.41 - Findings of no significant impact.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... impact. (a) As defined by the CEQ regulations (40 CFR 1508.13), a FONSI is a document prepared by a... human environment and for which, therefore, an EIS will not be prepared. A FONSI includes the EA or a...) responsible for approving the FONSI will sign the document, thereby establishing that the official(s)...

  18. 21 CFR 25.41 - Findings of no significant impact.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... impact. (a) As defined by the CEQ regulations (40 CFR 1508.13), a FONSI is a document prepared by a... human environment and for which, therefore, an EIS will not be prepared. A FONSI includes the EA or a...) responsible for approving the FONSI will sign the document, thereby establishing that the official(s)...

  19. 10 CFR 1021.322 - Findings of no significant impact.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... review and comment before making a final determination on the FONSI if required by 40 CFR 1501.4(e)(2... CFR 1506.1 and § 1021.211 of this part. (b) In addition to the requirements found at 40 CFR 1508.13, a... this part; (2) Any “Statement of Findings” required by 10 CFR part 1022, “Compliance with...

  20. 21 CFR 25.41 - Findings of no significant impact.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... impact. (a) As defined by the CEQ regulations (40 CFR 1508.13), a FONSI is a document prepared by a... human environment and for which, therefore, an EIS will not be prepared. A FONSI includes the EA or a...) responsible for approving the FONSI will sign the document, thereby establishing that the official(s)...

  1. 21 CFR 25.41 - Findings of no significant impact.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... impact. (a) As defined by the CEQ regulations (40 CFR 1508.13), a FONSI is a document prepared by a... human environment and for which, therefore, an EIS will not be prepared. A FONSI includes the EA or a...) responsible for approving the FONSI will sign the document, thereby establishing that the official(s)...

  2. 21 CFR 25.41 - Findings of no significant impact.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... impact. (a) As defined by the CEQ regulations (40 CFR 1508.13), a FONSI is a document prepared by a... human environment and for which, therefore, an EIS will not be prepared. A FONSI includes the EA or a...) responsible for approving the FONSI will sign the document, thereby establishing that the official(s)...

  3. 23 CFR 771.121 - Findings of no significant impact.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... written FONSI incorporating by reference the EA and any other appropriate environmental documents. (b) After a FONSI has been made by the Administration, a notice of availability of the FONSI shall be sent...) If another Federal agency has issued a FONSI on an action which includes an element proposed...

  4. Significant findings concerning the production of Italian Renaissance lustred majolica

    NASA Astrophysics Data System (ADS)

    Padeletti, G.; Fermo, P.

    2013-12-01

    In the present paper the main results obtained, over a period of more than ten years, from a series of studies concerning the characterization of Italian Renaissance lustred majolicas (from Gubbio and Deruta, Umbria, Italy) are presented. Lustre decoration is a well-known technique, consisting in the application of a thin metallic iridescent film, containing silver and copper nanoparticles, over a previously glazed ceramic object. The technique had its origin in Persia (IX century), was imported by Moorish in Spain, and then developed in central Italy during the Renaissance period. Numerous analytical techniques (among which, ETASS, XRD, UV-Vis, SEM-EDX) have been employed for the characterization of lustred ceramic shards, allowing one to acquire information on both lustre chemical composition and nanostructure. In this way it was shown how some technological parameters, such as the firing conditions, are mandatory to obtain the final result. The presence of a specific marker of the lustre Italian production, i.e., cosalite (Pb2Bi2S5), has been also highlighted. From the study of the ceramic body composition (by means of XRD and ICP-OES and in particular of chemometric techniques) acquired on more than 50 ceramic shards it was possible to discriminate between Deruta and Gubbio production, in this way allowing one to assign objects of uncertain provenance to a specific site. Finally, the most interesting results obtained studying excellent lustred masterpieces from Renaissance belonging to important museums are here presented. In particular, with the use of nondestructive techniques (PIXE, RBS, and portable XRD), the production of Mastro Giorgio Andreoli from Gubbio was investigated. By means of the same analytical approach, one of the first examples of lustre in Italy (the famous Baglioni's albarello) was examined, and the controversial question of its attribution to Italian production was scientifically faced.

  5. 46 CFR 504.6 - Finding of no significant impact.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... the Commission within ten (10) days from the date of publication of the notice of its availability in... an EIS pursuant to § 504.7. The Commission shall, within ten (10) days of receipt of the...

  6. Acid soil infertility effects on peanut yields and yield components

    SciTech Connect

    Blamey, F.P.C.

    1983-01-01

    The interpretation of soil amelioration experiments with peanuts is made difficult by the unpredictibility of the crop and by the many factors altered when ameliorating acid soils. The present study was conducted to investigate the effects of lime and gypsum applications on peanut kernel yield via the three first order yield components, pods per ha, kernels per pod, and kernel mass. On an acid medium sandy loam soil (typic Plinthustult), liming resulted in a highly significant kernel yield increase of 117% whereas gypsum applications were of no significant benefit. As indicated by path coefficient analysis, an increase in the number of pods per ha was markedly more important in increasing yield than an increase in either the number of kernels per pod or kernel mass. Furthermore, exch. Al was found to be particularly detrimental to pod number. It was postulated that poor peanut yields resulting from acid soil infertility were mainly due to the depressive effect of exch. Al on pod number. Exch. Ca appeared to play a secondary role by ameliorating the adverse effects of exch. Al.

  7. Effects of geoengineering on crop yields

    NASA Astrophysics Data System (ADS)

    Pongratz, J.; Lobell, D. B.; Cao, L.; Caldeira, K.

    2011-12-01

    The potential of "solar radiation management" (SRM) to reduce future climate change and associated risks has been receiving significant attention in scientific and policy circles. SRM schemes aim to reduce global warming despite increasing atmospheric CO2 concentrations by diminishing the amount of solar insolation absorbed by the Earth, for example, by injecting scattering aerosols into the atmosphere. Climate models predict that SRM could fully compensate warming at the global mean in a high-CO2 world. While reduction of global warming may offset a part of the predicted negative effects of future climate change on crop yields, SRM schemes are expected to alter regional climate and to have substantial effects on climate variables other than temperature, such as precipitation. It has therefore been warned that, overall, SRM may pose a risk to food security. Assessments of benefits and risks of geoengineering are imperative, yet such assessments are only beginning to emerge; in particular, effects on global food security have not previously been assessed. Here, for the first time, we combine climate model simulations with models of crop yield responses to climate to assess large-scale changes in yields and food production under SRM. In most crop-growing regions, we find that yield losses caused by climate changes are substantially reduced under SRM as compared with a non-geoengineered doubling of atmospheric CO2. Substantial yield losses with SRM are only found for rice in high latitudes, where the limits of low temperatures are no longer alleviated. At the same time, the beneficial effect of CO2-fertilization on plant productivity remains active. Overall therefore, SRM in our models causes global crop yields to increase. We estimate the direct effects of climate and CO2 changes on crop production, and do not quantify effects of market dynamics and management changes. We note, however, that an SRM deployment would be unlikely to maintain the economic status quo, as

  8. Changes in diurnal temperature range and national cereal yields

    SciTech Connect

    Lobell, D

    2007-04-26

    Models of yield responses to temperature change have often considered only changes in average temperature (Tavg), with the implicit assumption that changes in the diurnal temperature range (DTR) can safely be ignored. The goal of this study was to evaluate this assumption using a combination of historical datasets and climate model projections. Data on national crop yields for 1961-2002 in the 10 leading producers of wheat, rice, and maize were combined with datasets on climate and crop locations to evaluate the empirical relationships between Tavg, DTR, and crop yields. In several rice and maize growing regions, including the two major nations for each crop, there was a clear negative response of yields to increased DTR. This finding reflects a nonlinear response of yields to temperature, which likely results from greater water and heat stress during hot days. In many other cases, the effects of DTR were not statistically significant, in part because correlations of DTR with other climate variables and the relatively short length of the time series resulted in wide confidence intervals for the estimates. To evaluate whether future changes in DTR are relevant to crop impact assessments, yield responses to projected changes in Tavg and DTR by 2046-2065 from 11 climate models were estimated. The mean climate model projections indicated an increase in DTR in most seasons and locations where wheat is grown, mixed projections for maize, and a general decrease in DTR for rice. These mean projections were associated with wide ranges that included zero in nearly all cases. The estimated impacts of DTR changes on yields were generally small (<5% change in yields) relative to the consistently negative impact of projected warming of Tavg. However, DTR changes did significantly affect yield responses in several cases, such as in reducing US maize yields and increasing India rice yields. Because DTR projections tend to be positively correlated with Tavg, estimates of yields

  9. Diversification practices reduce organic to conventional yield gap.

    PubMed

    Ponisio, Lauren C; M'Gonigle, Leithen K; Mace, Kevi C; Palomino, Jenny; de Valpine, Perry; Kremen, Claire

    2015-01-22

    Agriculture today places great strains on biodiversity, soils, water and the atmosphere, and these strains will be exacerbated if current trends in population growth, meat and energy consumption, and food waste continue. Thus, farming systems that are both highly productive and minimize environmental harms are critically needed. How organic agriculture may contribute to world food production has been subject to vigorous debate over the past decade. Here, we revisit this topic comparing organic and conventional yields with a new meta-dataset three times larger than previously used (115 studies containing more than 1000 observations) and a new hierarchical analytical framework that can better account for the heterogeneity and structure in the data. We find organic yields are only 19.2% (±3.7%) lower than conventional yields, a smaller yield gap than previous estimates. More importantly, we find entirely different effects of crop types and management practices on the yield gap compared with previous studies. For example, we found no significant differences in yields for leguminous versus non-leguminous crops, perennials versus annuals or developed versus developing countries. Instead, we found the novel result that two agricultural diversification practices, multi-cropping and crop rotations, substantially reduce the yield gap (to 9 ± 4% and 8 ± 5%, respectively) when the methods were applied in only organic systems. These promising results, based on robust analysis of a larger meta-dataset, suggest that appropriate investment in agroecological research to improve organic management systems could greatly reduce or eliminate the yield gap for some crops or regions. PMID:25621333

  10. Diversification practices reduce organic to conventional yield gap

    PubMed Central

    Ponisio, Lauren C.; M'Gonigle, Leithen K.; Mace, Kevi C.; Palomino, Jenny; de Valpine, Perry; Kremen, Claire

    2015-01-01

    Agriculture today places great strains on biodiversity, soils, water and the atmosphere, and these strains will be exacerbated if current trends in population growth, meat and energy consumption, and food waste continue. Thus, farming systems that are both highly productive and minimize environmental harms are critically needed. How organic agriculture may contribute to world food production has been subject to vigorous debate over the past decade. Here, we revisit this topic comparing organic and conventional yields with a new meta-dataset three times larger than previously used (115 studies containing more than 1000 observations) and a new hierarchical analytical framework that can better account for the heterogeneity and structure in the data. We find organic yields are only 19.2% (±3.7%) lower than conventional yields, a smaller yield gap than previous estimates. More importantly, we find entirely different effects of crop types and management practices on the yield gap compared with previous studies. For example, we found no significant differences in yields for leguminous versus non-leguminous crops, perennials versus annuals or developed versus developing countries. Instead, we found the novel result that two agricultural diversification practices, multi-cropping and crop rotations, substantially reduce the yield gap (to 9 ± 4% and 8 ± 5%, respectively) when the methods were applied in only organic systems. These promising results, based on robust analysis of a larger meta-dataset, suggest that appropriate investment in agroecological research to improve organic management systems could greatly reduce or eliminate the yield gap for some crops or regions. PMID:25621333

  11. 76 FR 16838 - Finding of No Significant Impact; Notice of Availability of the Finding of No Significant Impact...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-03-25

    ... Contractor To House Approximately 1,000 Federal, Low-Security, Adult Male, Non-US Citizen, Criminal Aliens at... contracts to house approximately, 1,000 federal, low-security, adult males, criminal aliens within one... U.S. Department of Homeland Security regarding sentenced and unsentenced criminal aliens....

  12. Yield Improvement in Steel Casting (Yield II)

    SciTech Connect

    Richard A. Hardin; Christoph Beckermann; Tim Hays

    2002-02-18

    This report presents work conducted on the following main projects tasks undertaken in the Yield Improvement in Steel Casting research program: Improvement of Conventional Feeding and Risering Methods, Use of Unconventional Yield Improvement Techniques, and Case Studies in Yield Improvement. Casting trials were conducted and then simulated using the precise casting conditions as recorded by the participating SFSA foundries. These results present a statistically meaningful set of experimental data on soundness versus feeding length. Comparisons between these casting trials and casting trials performed more than forty years ago by Pellini and the SFSA are quite good and appear reasonable. Comparisons between the current SFSA feeding rules and feeding rules based on the minimum Niyama criterion reveal that the Niyama-based rules are generally less conservative. The niyama-based rules also agree better with both the trials presented here, and the casting trails performed by Pellini an d the SFSA years ago. Furthermore, the use of the Niyama criterion to predict centerline shrinkage for horizontally fed plate sections has a theoretical basis according to the casting literature reviewed here. These results strongly support the use of improved feeding rules for horizontal plate sections based on the Niyama criterion, which can be tailored to the casting conditions for a given alloy and to a desired level of soundness. The reliability and repeatability of ASTM shrinkage x-ray ratings was investigated in a statistical study performed on 128 x-rays, each of which were rated seven different times. A manual ''Feeding and Risering Guidelines for Steel Castings' is given in this final report. Results of casting trials performed to test unconventional techniques for improving casting yield are presented. These use a stacked arrangement of castings and riser pressurization to increase the casting yield. Riser pressurization was demonstrated to feed a casting up to four time s the

  13. Reckoning wheat yield trends

    NASA Astrophysics Data System (ADS)

    Lin, M.; Huybers, P.

    2012-06-01

    Wheat yields have increased approximately linearly since the mid-twentieth century across the globe, but stagnation of these trends has now been suggested for several nations. We present a new statistical test for whether a yield time series has leveled off and apply it to wheat yield data from 47 different regions to show that nearly half of the production within our sample has transitioned to level trajectories. With the major exception of India, the majority of leveling in wheat yields occurs within developed nations—including the United Kingdom, France and Germany—whose policies appear to have disincentivized yield increases relative to other objectives. The effects of climate change and of yields nearing their maximum potential may also be important.

  14. Atmospheric Nitrogen Fluorescence Yield

    NASA Technical Reports Server (NTRS)

    Adams, J. H., Jr.; Christl, M. J.; Fountain, W. F.; Gregory, J. C.; Martens, K. U.; Sokolsky, Pierre; Whitaker, Ann F. (Technical Monitor)

    2001-01-01

    Several existing and planned experiments estimate the energies of ultra-high energy cosmic rays from air showers using the atmospheric nitrogen fluorescence. The nitrogen fluorescence yield from air shower electrons depends on the atmospheric composition. We will discuss the uncertainties in the fluorescence yield form electrons in the real atmosphere and describe a concept for a small balloon payload to measure the atmospheric fluorescence yield as a function of attitude.

  15. Reed canarygrass yield improvement

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Reed canarygrass is well adapted to the northern USA. Eight cultivars and 72 accessions collected in rural landscapes from Iowa to New Hampshire were evaluated for yield. Accessions produced on average 7% higher biomass yield compared to existing cultivars. Naturalized populations of reed canarygras...

  16. Heterogeneous global crop yield response to biochar: a meta-regression analysis

    NASA Astrophysics Data System (ADS)

    Crane-Droesch, Andrew; Abiven, Samuel; Jeffery, Simon; Torn, Margaret S.

    2013-12-01

    Biochar may contribute to climate change mitigation at negative cost by sequestering photosynthetically fixed carbon in soil while increasing crop yields. The magnitude of biochar’s potential in this regard will depend on crop yield benefits, which have not been well-characterized across different soils and biochars. Using data from 84 studies, we employ meta-analytical, missing data, and semiparametric statistical methods to explain heterogeneity in crop yield responses across different soils, biochars, and agricultural management factors, and then estimate potential changes in yield across different soil environments globally. We find that soil cation exchange capacity and organic carbon were strong predictors of yield response, with low cation exchange and low carbon associated with positive response. We also find that yield response increases over time since initial application, compared to non-biochar controls. High reported soil clay content and low soil pH were weaker predictors of higher yield response. No biochar parameters in our dataset—biochar pH, percentage carbon content, or temperature of pyrolysis—were significant predictors of yield impacts. Projecting our fitted model onto a global soil database, we find the largest potential increases in areas with highly weathered soils, such as those characterizing much of the humid tropics. Richer soils characterizing much of the world’s important agricultural areas appear to be less likely to benefit from biochar.

  17. The fingerprint of climate trends on European crop yields

    PubMed Central

    Moore, Frances C.; Lobell, David B.

    2015-01-01

    Europe has experienced a stagnation of some crop yields since the early 1990s as well as statistically significant warming during the growing season. Although it has been argued that these two are causally connected, no previous studies have formally attributed long-term yield trends to a changing climate. Here, we present two statistical tests based on the distinctive spatial pattern of climate change impacts and adaptation, and explore their power under a range of parameter values. We show that statistical power for the identification of climate change impacts is high in many settings, but that power for identifying adaptation is almost always low. Applying these tests to European agriculture, we find evidence that long-term temperature and precipitation trends since 1989 have reduced continent-wide wheat and barley yields by 2.5% and 3.8%, respectively, and have slightly increased maize and sugar beet yields. These averages disguise large heterogeneity across the continent, with regions around the Mediterranean experiencing significant adverse impacts on most crops. This result means that climate trends can account for ∼10% of the stagnation in European wheat and barley yields, with likely explanations for the remainder including changes in agriculture and environmental policies. PMID:25691735

  18. Predicting Memory for Childhood Sexual Abuse: "Non-Significant" Findings with the Potential for Significant Harm

    ERIC Educational Resources Information Center

    Zurbriggen, Eileen L.; Becker-Blease, Kathryn

    2003-01-01

    In the March 2003 issue of "Psychological Science", the flagship journal of the American Psychological Society, Goodman et al. (2003) reported on a prospective study that examined memory for childhood sexual abuse. The authors interviewed adolescents and young adults who had been victims of documented childhood sexual abuse that led to criminal…

  19. Management of ISOLDE yields

    NASA Astrophysics Data System (ADS)

    Turrión, M.; Eller, M.; Catherall, R.; Fraile, L. M.; Herman-Izycka, U.; Köster, U.; Lettry, J.; Riisager, K.; Stora, Th.

    2008-10-01

    Isotope yields at ISOLDE are regularly measured online (with dedicated gamma and beta detectors) and off line by implantation and subsequent alpha-, beta- or gamma spectroscopy. The Java based measurement software, dedicated to tape station measurements, has been updated in order to automate yield measurements and provide possibilities to repeat existing measurements. A procedure supported by dedicated programs was established to analyze data. The results are centrally stored and provide an interface to the existing ISOLDE yield database. The present ISOLDE yield database has been recently created and updated with a large number of yields compiled from published data. The database developed on ORACLE guarantees reliability and security and provides a simple way of compiling new information. A user oriented interface has been programmed allowing accessing the information via a web browser. Several levels in the database structure provide selective access to different layers of technical information for advanced users and for technical R&D. The improvements in the yield measurement procedure, the data storage and accessibility, as well as the new database structure, the web application and the access interfaces, enhance the communication between technical information like yields and the users of the ISOLDE facility.

  20. Crop status evaluations and yield predictions

    NASA Technical Reports Server (NTRS)

    Haun, J. R.

    1975-01-01

    A model was developed for predicting the day 50 percent of the wheat crop is planted in North Dakota. This model incorporates location as an independent variable. The Julian date when 50 percent of the crop was planted for the nine divisions of North Dakota for seven years was regressed on the 49 variables through the step-down multiple regression procedure. This procedure begins with all of the independent variables and sequentially removes variables that are below a predetermined level of significance after each step. The prediction equation was tested on daily data. The accuracy of the model is considered satisfactory for finding the historic dates on which to initiate yield prediction model. Growth prediction models were also developed for spring wheat.

  1. Low-Yield Cigarettes

    MedlinePlus

    ... Secondhand Smoke Smokeless Products Youth Tobacco Prevention Tobacco Industry and Products Federal Tax Increase Tobacco Ingredient Reporting ... be used. 3 In the past, the tobacco industry categorized low-yield cigarettes using measurements of tar ...

  2. Argentina soybean yield model

    NASA Technical Reports Server (NTRS)

    Callis, S. L.; Sakamoto, C.

    1984-01-01

    A model based on multiple regression was developed to estimate soybean yields for the country of Argentina. A meteorological data set was obtained for the country by averaging data for stations within the soybean growing area. Predictor variables for the model were derived from monthly total precipitation and monthly average temperature. A trend variable was included for the years 1969 to 1978 since an increasing trend in yields due to technology was observed between these years.

  3. Argentina corn yield model

    NASA Technical Reports Server (NTRS)

    Callis, S. L.; Sakamoto, C.

    1984-01-01

    A model based on multiple regression was developed to estimate corn yields for the country of Argentina. A meteorological data set was obtained for the country by averaging data for stations within the corn-growing area. Predictor variables for the model were derived from monthly total precipitation, average monthly mean temperature, and average monthly maximum temperature. A trend variable was included for the years 1965 to 1980 since an increasing trend in yields due to technology was observed between these years.

  4. Argentina wheat yield model

    NASA Technical Reports Server (NTRS)

    Callis, S. L.; Sakamoto, C.

    1984-01-01

    Five models based on multiple regression were developed to estimate wheat yields for the five wheat growing provinces of Argentina. Meteorological data sets were obtained for each province by averaging data for stations within each province. Predictor variables for the models were derived from monthly total precipitation, average monthly mean temperature, and average monthly maximum temperature. Buenos Aires was the only province for which a trend variable was included because of increasing trend in yield due to technology from 1950 to 1963.

  5. Event-Based Modeling of Driver Yielding Behavior to Pedestrians at Two-Lane Roundabout Approaches

    PubMed Central

    Salamati, Katayoun; Schroeder, Bastian J.; Geruschat, Duane R.; Rouphail, Nagui M.

    2013-01-01

    Unlike other types of controlled intersections, drivers do not always comply with the “yield to pedestrian” sign at the roundabouts. This paper aims to identify the contributing factors affecting the likelihood of driver yielding to pedestrians at two-lane roundabouts. It further models the likelihood of driver yielding based on these factors using logistic regression. The models have been applied to 1150 controlled pedestrian crossings at entry and exit legs of two-lane approaches of six roundabouts across the country. The logistic regression models developed support prior research that the likelihood of driver yielding at the entry leg of roundabouts is higher than at the exit. Drivers tend to yield to pedestrians carrying a white cane more often than to sighted pedestrians. Drivers traveling in the far lane, relative to pedestrian location, have a lower probability of yielding to a pedestrian. As the speed increases the probability of driver yielding decreases. At the exit leg of the roundabout, drivers turning right from the adjacent lane have a lower propensity of yielding than drivers coming from other directions. The findings of this paper further suggest that although there has been much debate on pedestrian right-of-way laws and distinction between pedestrian waiting positions (in the street versus at the curb), this factor does not have a significant impact on driver yielding rate. The logistic regression models also quantify the effect of each of these factors on propensity of driver yielding. The models include variables which are specific to each study location and explain the impact size of each study location on probability of yielding. The models generated in this research will be useful to transportation professionals and researchers interested in understanding the factors that impact driver yielding at modern roundabouts. The results of the research can be used to isolate factors that may increase yielding (such as lower roundabout approach

  6. Improving Photosynthetic Efficiency for Greater Yield

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Increasing the yield potential of the major food grain crops has contributed very significantly to a rising global supply of grain over the past 50 years, which has until recently more than kept pace with rising global demand. Yield potential is the product of the solar radiation available at a giv...

  7. Weed competition and dry bean yield components

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Weed competition can significantly reduce dry bean (Phaseolus vulgaris L.) yields and therefore the profitability for the producer. Depending on the dry bean variety produced, the yield components may be affected differently by the stress produced by weed competition. This research was conducted to ...

  8. The Fingerprint of Climate Trends on European Crop Yields

    NASA Astrophysics Data System (ADS)

    Moore, F.; Lobell, D. B.

    2014-12-01

    Europe has experienced a stagnation of some crop yields since the early-1990s as well as statistically-significant warming during the growing-season. While it has been argued that these two are causally connected, no previous studies have formally attributed long-term European yield trends to a changing climate. Here we present two statistical tests based on the distinctive spatial pattern of climate change impacts and adaptation, and explore their power under a range of parameter values. We show that statistical power for the identification of climate change impacts is high in many settings, but that power for identifying adaptation is almost always low. Applying these test to European agriculture, we find evidence that long-term temperature and precipitation trends have reduced continent-wide wheat, maize, and barley yields by 2.7%, 1.1%, and 3.9% respectively, and have increased sugarbeet yields by 1.0%. This can account for approximately 10% of the yield stagnation in Europe, with changes in agricultural and environmental policies likely explaining the remainder.

  9. Ab initio yield curve dynamics [rapid communication

    NASA Astrophysics Data System (ADS)

    Hawkins, Raymond J.; Roy Frieden, B.; D'Anna, Joseph L.

    2005-09-01

    We derive an equation of motion for interest-rate yield curves by applying a minimum Fisher information variational approach to the implied probability density. By construction, solutions to the equation of motion recover observed bond prices. More significantly, the form of the resulting equation explains the success of the Nelson Siegel approach to fitting static yield curves and the empirically observed modal structure of yield curves. A practical numerical implementation of this equation of motion is found by using the Karhunen Lòeve expansion and Galerkin's method to formulate a reduced-order model of yield curve dynamics.

  10. Yield threshold decision framework

    SciTech Connect

    Judd, B.R.; Younker, L.W.; Hannon, W.J.

    1989-08-17

    The USA is developing a decision analysis framework for evaluating the relative value of lower yield thresholds and related verification policies. The framework facilitates systematic analysis of the major issues in the yield threshold decision. The framework can be used to evaluate options proposed either in the inter-agency process or in the negotiations. In addition, the framework can measure the importance of uncertainties and alternative judgments, and thereby determine the advantages of additional research. Since the model is explicit and quantitative, it provides a rational, defensible approach for reaching important treaty and verification decisions. 9 figs.