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1

Simulación numérica del transporte del herbicida glifosato en la zona no saturada  

Microsoft Academic Search

RESUMEN. La simulación numérica junto con los experimentos de campo constituyen herramientas imprescindibles para el estudio del transporte de agua y de sustancias contaminantes en el subsuelo. El objetivo de este trabajo es presentar un modelo numérico para describir la migración de un contaminante sometido a procesos de adsorción y de degradación en la zona no saturada (ZNS) del terreno.

L. Guarracino; L. Candela Lledó; J. E. Santos

1999-01-01

2

Incentivos para atraer y retener personal de salud de zonas rurales del Perú: un estudio cualitativo  

PubMed Central

El objetivo fue identificar incentivos de atracción y retención en zonas rurales y distantes de Ayacucho, Perú. Fueron realizadas entrevistas en profundidad con 80 médicos, enfermeras, obstetras y técnicos (20 por grupo) de las zonas más pobres y con 11 funcionarios. No existen políticas sistemáticas de atracción y retención de personal de salud en Ayacucho. Los principales incentivos, en orden de importancia, fueron mejoras salariales, oportunidades de formación y capacitación, estabilidad laboral y nombramiento, mejoras en infraestructura y equipos, e incremento del personal. Se mencionaron también mejoras en la vivienda y alimentación, mayor cercanía con la familia y reconocimiento por el sistema de salud. Existen coincidencias y singularidades entre los distintos grupos sobre los incentivos clave para estimular el trabajo rural, que deben considerarse al diseñar políticas públicas. Las iniciativas del Estado deben comprender procesos rigurosos de monitoreo y evaluación, para asegurar que las mismas tengan el impacto deseado. PMID:22488318

Huicho, Luis; Canseco, Francisco Díez; Lema, Claudia; Miranda, J. Jaime; Lescano, Andrés G.

2014-01-01

3

COMPARACIÓN DE VARIOS MÉTODOS PARA LA REPRESENTACIÓN CARTOGRÁFICA DE INFORMACIÓN CLIMÁTICA EN ZONAS ALTAS DEL ESTADO LARA  

Microsoft Academic Search

Se compararon tres métodos cartográficos diferentes para la representación de aspectos climáticos (temperatura y precipitación) en zonas altas del estado Lara. Se usó conjuntamente A) Representación analógica (en papel), B) Mapas digitalizados de coberturas mediante el software para Sistema de Información Geográfica (SIG) ArcInfo y C) Modelos numéricos interpolados mediante software de aplicación geoestadística (SURFER), empleando el modelo de interpolación

Jorge López Márquez; Rigoberto Andressen

2001-01-01

4

RELACIÓN SUELO-ÁRBOL Y FACTORES DE SITIO, EN PLANTACIONES JÓVENES DE TECA (Tectona grandis), EN LA ZONA OESTE DE LA CUENCA DEL CANAL DE PANAMÁ  

Microsoft Academic Search

Recibido: 07\\/12\\/04 Aceptado: 01\\/03\\/05 RE SU MEN Mediante la utilización de un muestreo factorial estratificado con 4 repeticiones (3x3x4) se seleccionaron 36 parcelas permanentes de medición en plantaciones de teca en la zona oeste de la cuenca del Canal de Panamá. En la estratifi- cación se emplearon como criterios el incremento medio anual (IMA) en altura total y la pendiente

Manuel Mollinedo; Luis Ugalde; Alfredo Alvarado; Jean Mark Verjans; Luis Carles Rudy

2005-01-01

5

LA TRANSICIÓN DEL PRECLÁSICO TARDÍO AL CLÁSICO TEMPRANO EN LA ZONA INTERSITIO DE XULTUN Y SAN BARTOLO EN PETÉN  

Microsoft Academic Search

Durante las últimas décadas se han llevado a cabo investigaciones intensivas sobre la sociedad Maya durante el Preclásico. En Guatemala, algunos proyectos como los de Tikal, Uaxactun, Takalik Ab ´aj, Kaminaljuyu, Holmul y la Cuenca Mirador, entre otros, han desempeñar un papel en esta reanudación de los estudios del Preclásico. Otros proyectos importantes en Belice y México, como Cerros, Lamanai,

Thomas G. Garrison

6

BASES PARA EL MANEJO INTEGRADO DEL RECURSO LANGOSTA (Panulirus argus) EN LA ZONA COSTERA SUR DE PINAR DEL RÍO. I. FACTORES AMBIENTALES  

Microsoft Academic Search

A study of management of costal areas in the western gulf of Batabanó, southern coast of Pinar del Río province, is presented in three parts: environmental factors, socio economical factors and integrated management. Main characteristics of natural factors are analyzed, such as river supply of water to the coast, water temperature, salinity, dissolved oxygen, turbidity, ph, nutrients and organic nitrogen

Roberto Piñeiro; Rafael Puga; Gaspar González-Sansón

7

Energía, industria y medio rural: el caso de las zonas de montaña españolas, 1850-2000  

Microsoft Academic Search

El trabajo analiza las relaciones entre recursos energéticos, actividades industriales y economías rurales en el marco del desarrollo de la España contemporánea, tomando como muestra las 84 principales comarcas montañosas del país. Para ello se han reconstruido series estadísticas acerca de la minería del carbón, la producción eléctrica o el grado de intensidad industrial de las diferentes zonas de montaña.

Fernando Collantes

2003-01-01

8

Inhibitory effect of homologous solubilized zona pellucida  

E-print Network

Inhibitory effect of homologous solubilized zona pellucida on rabbit in vitro fertilization Martine the fertilization rate (10 versus 55 % for the control). Ultrastructural analysis of several oocytes in the two groups demonstrated that inhibition of fertilization was not due to the inhibition of sperm-zona binding

Paris-Sud XI, Université de

9

Impacto del agua de cola de la industria pesquera: tratamientos y usos Impact of stickwater produced by the fishery industry: treatment and uses  

Microsoft Academic Search

The effluent produced by the seafood industry especially stickwater is the main source of pollution in seas where these industries have been established. Therefore, there are currently several processes for treatment, which covers physical, chemical and biological methods. Currently, efforts are being made in both: stickwater treatment as well as the recovery of solids from it that can be reinstated

C. O. García-Sifuentes; R. Pacheco-Aguilar; S. Valdez-Hurtado; E. Márquez-Rios; M. E. Lugo-Sánchez; J. M. Ezquerra-Brauer

2009-01-01

10

I1 piano regolatore di iina citt di circa 50.000 abitanti, in una zona pianeggiante di nuova espansione che fronteggia il mare e confina con una zona a verde pubblico, prevista una  

E-print Network

I1 piano regolatore di iina città di circa 50.000 abitanti, in una zona pianeggiante di nuova piano di recupero di un ambito urbano ricadente in un centro storico, con una rilevante presenza di candidato illustrerà la normativa di riferimento per la redazione del piano di recupero con particolare

Di Pillo, Gianni

11

Futuras fuentes de crecimiento de la productividad del trigo en la region del Baj?o (Guanajuato, Mexico)  

Microsoft Academic Search

El objetivo de esta investigaci?n es determinar la perspectiva de la producci?n de trigo en la regi?n del Baj?o (Guanajuato, M?xico), como una zona estrat?gica para proveer la materia prima que requiere la industria molinera de la zona centro del pa?s. Se determin? el comportamiento de los componentes de la producci?n mediante el c?lculo de las tasas de crecimiento. Asimismo,

Pedro Aquino-Mercado

2003-01-01

12

Transcriptome Analysis Reveals Differentially Expressed Transcripts in Rat Adrenal Zona Glomerulosa and Zona Fasciculata  

PubMed Central

In mammals, aldosterone is produced in the zona glomerulosa (zG), the outermost layer of the adrenal cortex, whereas glucocorticoids are produced in adjacent zona fasciculata (zF). However, the cellular mechanisms controlling the zonal development and the differential hormone production (i.e. functional zonation) are poorly understood. To explore the mechanisms, we defined zone-specific transcripts in this study. Eleven-week-old male rats were used and adrenal tissues were collected from zG and zF using laser-capture microdissection. RNA was isolated, biotin labeled, amplified, and hybridized to Illumina microarray chips. The microarray data were compared by fold change calculations. In zG, 235 transcripts showed more than a 2-fold up-regulation compared to zF with statistical significance. Similarly, 231 transcripts showed up-regulation in zF. The microarray findings were validated using quantitative RT-PCR and immunohistochemical staining on selected transcripts, including Cyp11b2 (zG/zF: 214.2x), Rgs4 (68.4x), Smoc2 (49.3x), and Mia1 (43.1x) in zG as well as Ddah1 (zF/zG 16.2x), Cidea (15.5x), Frzb (9.5x), and Hsd11b2 (8.3x) in zF. The lists of transcripts obtained in the current study will be an invaluable tool for the elucidation of cellular mechanisms leading to zG and zF functional zonation. PMID:22374966

Nishimoto, Koshiro; Rigsby, Christine S.; Wang, Tao; Mukai, Kuniaki; Gomez-Sanchez, Celso E.; Rainey, William E.

2012-01-01

13

SISTEMA REMOTO DE ADQUISICIÓN PARA EL CONTROL DEL RUIDO AMBIENTAL CON FPGA Y FPAA  

Microsoft Academic Search

RESUMEN Este artículo propone el diseño de un sistema de adquisición de datos con componentes digitales y analógicos microelectrónicos reconfigurables, como son el FPGA (Field Programmable Gate Array) y el FPAA (Field Programmable Analog Array), para monitorear y analizar la contaminación por ruido ambiental. Este prototipo obtiene los datos del ruido de una zona vial (zona centro de una ciudad)

A. Castillo Atoche; J. Vázquez Castillo; V. Sanchez Huerta; P. Del Río Dawn

14

The practical side of immunocontraception: zona proteins and wildlife  

Microsoft Academic Search

With shrinking habitat, the humane control of certain wildlife populations is relevant. The contraceptive vaccine based on native porcine zona pellucida (PZP) has been applied to various wildlife populations for 20 years. Prominent efforts include wild horses, urban deer, zoo animals and African elephants, among others. This approach has been successful in managing entire populations and to date, no significant

J. F. Kirkpatrick; A. Rowan; N. Lamberski; R. Wallace; K. Frank; R. Lyda

2009-01-01

15

Mechanics of sperm-egg interaction at the zona pellucida.  

PubMed Central

Mammalian sperm traverse several layers of egg vestments before fertilization can occur. The innermost vestment, the zona pellucida, is a glycoprotein shell, which captures and tethers the sperm before they penetrate it. We report here direct measurements of the force required to tether a motile human sperm as well as independent calculations of this force using flagellar beat parameters observed for sperm of several species on their homologous zonae. We have compared these sperm-generated forces with the calculated tensile strength of sperm-zona bonds, and found that a motile sperm can be tethered, at least temporarily, by a single bond. Therefore, sperm can be captured by the first bond formed and tethered permanently by a few. The sperm cannot subsequently penetrate the zona unless the bonds are first eliminated. However, premature elimination would simply allow the sperm to escape. Therefore, not only must the bonds be eliminated, but the timing of this must be regulated so that the sperm is already oriented toward the egg and beginning to penetrate as the bonds are broken. Images FIGURE 6 PMID:3224150

Baltz, J M; Katz, D F; Cone, R A

1988-01-01

16

El sector industrial del Tolima: aproximación histórica, estructura y dinámica  

Microsoft Academic Search

En virtud de las exenciones tributarias y arancelarias que dispuso el gobierno con el fin de reactivar la economía de la zona afectada por la erupción del volcán-nevado del Ruiz en 1985, la industria tolimense experimentó un período de auge entre 1990 y 1995, durante el cual creció la base industrial y se logró cierto grado de diversificación; sin embargo,

Alvaro Augusto Campos Martínez

2004-01-01

17

Outcomes of preimplantation genetic diagnosis using either zona drilling with acidified Tyrode's solution or partial zona dissection  

PubMed Central

Objective To review the outcomes of preimplantation genetic diagnosis (PGD) using zona drilling with acid Tyrode's solution (chemical zona pellucida drilling, chemical ZD) and those of partial zona dissection (PZD). Methods Clinical outcomes of seventy-one couples undergoing 85 PGD cycles from January 2005 to December 2010 were included. Blastocyst formation and the hatching rate, clinical pregnancy rate, ongoing pregnancy rate, implantation rate, and fetal gender ratio of the PZD and chemical ZD groups were compared. Results Application of PZD resulted in a significantly higher rate of clinical pregnancy (40.7% vs. 15.4%, p=0.022), ongoing pregnancy (35.6% vs. 11.5%, p=0.023), and implantation (18.1% vs. 5.7%, p=0.007) compared with chemical ZD. Among non-transferred embryos, the rate of blastocyst formation on day 5 (49.1% vs. 39.5%, p=0.016) and hatching on day 6 (47.2% vs. 26.5%, p<0.001) were also significantly higher in the PZD group. Conclusion The mechanical zona dissection method showed better outcomes than chemical ZD in terms of the blastocyst development and pregnancy rate. In this study, the fact that chemical ZD was conducted in different period from mechanical method should be considered in interpreting the result. PMID:23106043

Kim, Hyun Jung; Kim, Chung Hyon; Lee, Soo Min; Choe, Seung Ah; Lee, Joong Yeup; Jee, Byung Chul; Hwang, Doyeong

2012-01-01

18

Prognostic value of various spermatological attributes as predictors of zona binding and zona penetration of buffalo (Bubalus bubalis) semen.  

PubMed

Twenty-four ejaculates from six (four ejaculates each) Surti buffalo bulls aged 4-8 years were used to assess various attributes of spermatozoa influencing the zona-binding and zona-penetration tests. Ejaculates from each bulls were subjected to in vitro sperm--zona binding and sperm--zona penetration tests (four replicates per bull) using immature buffalo oocytes. The average number of spermatozoa bound per oocyte was 27.79 +/- 5.90. The average number of spermatozoa penetrated per oocyte was 3.35 +/- 0.64. The average number of zona-bound and -penetrated spermatozoa differed significantly between animals. Significant difference (p < 0.05) was observed between the plasmalemma integrity as assessed by eosin--nigrosin stain and hypo-osmotic swelling (HOS) test. Furthermore, the percentage of cells positive for the HOS test, i.e. functional membrane integrity (51.25 +/- 2.32) was significantly (p < 0.05) higher than hypo-osmotic swelling-Giemsa (HOS-G) test, i.e. the subpopulation of spermatozoa positive for functional membrane and acrosomal integrities (42.87 +/- 4.56). The HOS test had significant correlations with plasmalemma integrity as measured by the vital stain, eosin--nigrosin (r = 0.85, p < 0.05). The HOS-G test also had significant correlation with plasmalemma integrity measured by vital stains such as eosin--nigrosin (r = 0.90, p < 0.05) and fluorogenic stains [carboxyfluorescein diacetate (CFDA) and propidium iodide (PI); r = 0.92, p < 0.01] and HOS test (r = 0.93), acrosomal integrity (r = 0.86, p < 0.05) and mitochondrial membrane potential (r = 0.99, p < 0.01). The plasmalemma integrity (fluorogenic stain), functional membrane integrity (HOS test), subpopulation of spermatozoa positive for functional membrane and acrosomal integrities (HOS-G test) and mitochondrial membrane potential had significant (p < 0.05) correlation with sperm zona binding and penetration. The present study indicates that these parameters could represent important determinants of sperm quality influencing zona binding and penetration. PMID:18673329

Selvaraju, S; Ghosh, J; Ravindra, J P

2009-02-01

19

Ultrastructural study of the interactions and fusion of ram spermatozoa with zona-free hamster oocytes  

E-print Network

Ultrastructural study of the interactions and fusion of ram spermatozoa with zona-free hamster, Czechoslovakia. Summary. The interaction of preincubated ram sperm with zona-free hamster oocytes was studied undertaken ultrastructural observations of the interactions of zona- free hamster oocytes with ram sperm

Paris-Sud XI, Université de

20

Role of zona pellucida glycoproteins during fertilization in humans.  

PubMed

In the last decade, scientific investigations pertaining to the role of zona pellucida (ZP) glycoproteins during fertilization in humans have led to new insights. This has been achieved using purified native/recombinant human zona proteins and transgenic mice expressing human ZP glycoproteins. The proposed model in mice of ZP glycoprotein-3 (ZP3) acting as primary sperm receptor and ZP glycoprotein-2 (ZP2) as secondary sperm receptor has been modified for sperm-egg binding in humans. ZP glycoprotein-1 (ZP1), ZP3, and ZP glycoprotein-4 (ZP4) have been shown to bind to the capacitated human sperm. ZP2 binds to the acrosome-reacted human spermatozoa. Further, the eggs obtained from transgenic mice expressing human ZP2 alone or in conjunction with other human instead of mouse zona proteins showed binding of human sperm, suggesting that ZP2 might also play a role in sperm-egg binding. This function has been mapped to a domain corresponding to amino acid residues 51-144 of ZP2. In contrast to mice, where ZP3 is the primary agonist for inducing the acrosome reaction, in humans, the acrosome reaction can be mediated by ZP1, ZP3, and ZP4. The effect of mutations in the genes encoding zona proteins on the ZP morphology and infertility has not been established. Further, the role of autoantibodies against ZP in women with 'unexplained infertility' leading to poor outcome of in vitro fertilization is currently controversial and needs further investigations. Understanding the role of ZP glycoproteins during human fertilization facilitates the development of new contraceptives and strategies to overcome the problem of infertility. PMID:25445843

Gupta, Satish Kumar

2015-04-01

21

Survey of zona pellucida antigens for immunocontraception of cats  

Microsoft Academic Search

The purpose of this study was to screen a panel of native zona pellucida (ZP) antigens isolated from five mammalian species for immunocontraceptive activity in the cat (Felis catus). Native soluble-isolated ZP (SIZP) was prepared from the ovaries of cows (bZP), cats (fZP), ferrets (feZP), dogs (cZP), and mink (mZP). Vaccines were constructed using SIZP from each of the above

Julie K. Levy; Marc Mansour; P. Cynda Crawford; Bill Pohajdak; Robert G. Brown

2005-01-01

22

Viscous forces are predominant in the zona pellucida mechanical resistance  

NASA Astrophysics Data System (ADS)

The zona pellucida (ZP) is a multilayer glycoprotein spherical shell surrounding mammalian eggs. The ZP's mechanical response plays a crucial role in mammalian fertilization and is a parameter commonly adopted in "in vitro fertilization" to characterize the oocytes quality. While it is assumed that ZP mechanical response is purely elastic, here we prove that dissipative forces cannot be neglected. Physiologically, this evidence implies that an increase in the spermatozoa motility can induce dramatic changes on the ZP reaction force turning ZP shell in an impenetrable barrier leading to fertility impairments.

Papi, Massimiliano; Maiorana, Alessandro; Douet, Cécile; Maulucci, Giuseppe; Parasassi, Tiziana; Brunelli, Roberto; Goudet, Ghylène; De Spirito, Marco

2013-01-01

23

Componentes naturales y de uso del suelo vulnerables a las variaciones del nivel del mar en la costa atlántica de México  

Microsoft Academic Search

Palabras clave Regionalizaci6n de costas, fislografia, vulnerabilidad costera, uso del suelo Absúact Geomorphological alaradenstia of the mastal iongitudinal prn* and the arrangwent of the physiographical stmcture allowed the rmnition of two zonas: a) the intertidai zone -a basic sntne for dired imoaci of sea leve1 dame: and b) an adjacent peritidál (supralittoral) hnge &n area of cushioning or of polential

Mano Arturo; Ortiz Pérez; Ana Patricia; Méndez Linares

24

Baculovirus-expressed recombinant human zona pellucida glycoprotein-B induces acrosomal exocytosis in capacitated spermatozoa in addition to zona pellucida glycoprotein-C  

Microsoft Academic Search

To facilitate our understanding of the role of zona pellucida glycoproteins during fertilization in humans, recombinant human zona pellucida glycoprotein-A (hZPA), -B (hZPB) and -C (hZPC) were obtained by using Escherichia coli and baculovirus expression systems. Analysis by SDS-PAGE and Western blot of the Ni-NTA affinity purified recombinant proteins revealed that the baculovirus-expressed hZPA, hZPB and hZPC have an apparent

Sanchita Chakravarty; K. Suraj; Satish Kumar Gupta

2005-01-01

25

Nanoscale characterization of the biomechanical hardening of bovine zona pellucida  

PubMed Central

The zona pellucida (ZP) is an extracellular membrane surrounding mammalian oocytes. The so-called zona hardening plays a key role in fertilization process, as it blocks polyspermy, which may also be caused by an increase in the mechanical stiffness of the ZP membrane. However, structural reorganization mechanisms leading to ZP's biomechanical hardening are not fully understood yet. Furthermore, a correct estimate of the elastic properties of the ZP is still lacking. Therefore, the aim of the present study was to investigate the biomechanical behaviour of ZP membranes extracted from mature and fertilized bovine oocytes to better understand the mechanisms involved in the structural reorganization of the ZP that may lead to the biomechanical hardening of the ZP. For that purpose, a hybrid procedure is developed by combining atomic force microscopy nanoindentation measurements, nonlinear finite element analysis and nonlinear optimization. The proposed approach allows us to determine the biomechanical properties of the ZP more realistically than the classical analysis based on Hertz's contact theory, as it accounts for the nonlinearity of finite indentation process, hyperelastic behaviour and material heterogeneity. Experimental results show the presence of significant biomechanical hardening induced by the fertilization process. By comparing various hyperelastic constitutive models, it is found that the Arruda–Boyce eight-chain model best describes the biomechanical response of the ZP. Fertilization leads to an increase in the degree of heterogeneity of membrane elastic properties. The Young modulus changes sharply within a superficial layer whose thickness is related to the characteristic distance between cross-links in the ZP filamentous network. These findings support the hypothesis that biomechanical hardening of bovine ZP is caused by an increase in the number of inter-filaments cross-links whose density should be higher in the ZP inner side. PMID:22675161

Boccaccio, Antonio; Frassanito, Maria Cristina; Lamberti, Luciano; Brunelli, Roberto; Maulucci, Giuseppe; Monaci, Maurizio; Papi, Massimiliano; Pappalettere, Carmine; Parasassi, Tiziana; Sylla, Lakamy; Ursini, Fulvio; De Spirito, Marco

2012-01-01

26

Nanoscale characterization of the biomechanical hardening of bovine zona pellucida.  

PubMed

The zona pellucida (ZP) is an extracellular membrane surrounding mammalian oocytes. The so-called zona hardening plays a key role in fertilization process, as it blocks polyspermy, which may also be caused by an increase in the mechanical stiffness of the ZP membrane. However, structural reorganization mechanisms leading to ZP's biomechanical hardening are not fully understood yet. Furthermore, a correct estimate of the elastic properties of the ZP is still lacking. Therefore, the aim of the present study was to investigate the biomechanical behaviour of ZP membranes extracted from mature and fertilized bovine oocytes to better understand the mechanisms involved in the structural reorganization of the ZP that may lead to the biomechanical hardening of the ZP. For that purpose, a hybrid procedure is developed by combining atomic force microscopy nanoindentation measurements, nonlinear finite element analysis and nonlinear optimization. The proposed approach allows us to determine the biomechanical properties of the ZP more realistically than the classical analysis based on Hertz's contact theory, as it accounts for the nonlinearity of finite indentation process, hyperelastic behaviour and material heterogeneity. Experimental results show the presence of significant biomechanical hardening induced by the fertilization process. By comparing various hyperelastic constitutive models, it is found that the Arruda-Boyce eight-chain model best describes the biomechanical response of the ZP. Fertilization leads to an increase in the degree of heterogeneity of membrane elastic properties. The Young modulus changes sharply within a superficial layer whose thickness is related to the characteristic distance between cross-links in the ZP filamentous network. These findings support the hypothesis that biomechanical hardening of bovine ZP is caused by an increase in the number of inter-filaments cross-links whose density should be higher in the ZP inner side. PMID:22675161

Boccaccio, Antonio; Frassanito, Maria Cristina; Lamberti, Luciano; Brunelli, Roberto; Maulucci, Giuseppe; Monaci, Maurizio; Papi, Massimiliano; Pappalettere, Carmine; Parasassi, Tiziana; Sylla, Lakamy; Ursini, Fulvio; De Spirito, Marco

2012-11-01

27

L’eruzione laterale etnea del novembre 1950 — dicembre 1951  

Microsoft Academic Search

Conclusione  L’eruzione etnea del 1950–51 si manifestata quasi senza segni premonitori, dopo una breve (meno di un anno) stasi del vulcano.\\u000a Essa si stabilita in una zona che stata gi teatro di precedenti eruzioni (1811) ed ha avuto un’attivit prevalentemente\\u000a effusiva di notevole durata. La lava emessa ha la composizione mineralogica identica alle lave emesse in questo secolo; essa\\u000a si differenzia

Gustavo Cumin

1954-01-01

28

DISTRIBUCIÓN DE COLIBRÍES EN LA ZONA BAJA DEL CENTRO DE VERACRUZ, MÉXICO  

Microsoft Academic Search

Distribution of hummingbirds in the lowlands of central Veracruz, Mexico. - Knowl- edge of the distribution of a birds provide information on their natural history and guides actions with goals on conservation. The current distribution of hummingbirds in the lowlands of central Veracruz (< 1500 m above sea level) is poorly known. Recent publications (1995-1999) that show distribution maps indicate

Raúl Ortiz-Pulido; Román Díaz

29

POTENCIAL REGIONAL DEL TURISMO EN LA ZONA METROPOLITANA DE TAMPICO, MÉXICO  

Microsoft Academic Search

This paper examines the territorial features of tourism in the metropolitan area of Tampi- co, one of the less promoted coastal resorts of Mexico. The basic assumption of the study is that, while not having the natural lure of other tropical tourist destinations in the country, such as those in the Caribbean, Tampico is a fundamental centre for tourism attracting

Á LVARO SÁNCHEZ CRISPÍN; Y ENRIQUE PROPIN FREJOMIL

2005-01-01

30

A duplicated motif controls assembly of zona pellucida domain proteins  

PubMed Central

Many secreted eukaryotic glycoproteins that play fundamental roles in development, hearing, immunity, and cancer polymerize into filaments and extracellular matrices through zona pellucida (ZP) domains. ZP domain proteins are synthesized as precursors containing C-terminal propeptides that are cleaved at conserved sites. However, the consequences of this processing and the mechanism by which nascent proteins assemble are unclear. By microinjection of mutated DNA constructs into growing oocytes and mammalian cell transfection, we have identified a conserved duplicated motif [EHP (external hydrophobic patch)/IHP (internal hydrophobic patch)] regulating the assembly of mouse ZP proteins. Whereas the transmembrane domain (TMD) of ZP3 can be functionally replaced by an unrelated TMD, mutations in either EHP or IHP do not hinder secretion of full-length ZP3 but completely abolish its assembly. Because mutants truncated before the TMD are not processed, we conclude that the conserved TMD of mammalian ZP proteins does not engage them in specific interactions but is essential for C-terminal processing. Cleavage of ZP precursors results in loss of the EHP, thereby activating secreted polypeptides to assemble by using the IHP within the ZP domain. Taken together, these findings suggest a general mechanism for assembly of ZP domain proteins. PMID:15079052

Jovine, Luca; Qi, Huayu; Williams, Zev; Litscher, Eveline S.; Wassarman, Paul M.

2004-01-01

31

Four glycoproteins are expressed in the cat zona pellucida.  

PubMed

The mammalian oocyte is surrounded by a matrix called the zona pellucida (ZP). This envelope participates in processes such as acrosome reaction induction, sperm binding and may be involved in speciation. In cat (Felis catus), this matrix is composed of at least three glycoproteins called ZP2, ZP3, and ZP4. However, recent studies have pointed to the presence of a fourth protein in several mammals (rat, human, hamster or rabbit), meaning that a reevaluation of cat ZP is needed. For this reason, the objective of this research was to analyze the protein composition of cat ZP by means of proteomic analysis. Using ZP from ovaries and oocytes, several peptides corresponding to four proteins were detected, yielding a coverage of 33.17%, 71.50%, 50.23%, and 49.64% for ZP1, ZP2, ZP3, and ZP4, respectively. Moreover, the expression of four genes was confirmed by molecular analysis. Using total RNA isolated from cat ovaries, the complementary deoxyribonucleic acids encoding cat ZP were partially amplified by reverse-transcribed polymerase chain reaction. Furthermore, ZP1 was totally amplified for the first time in this species. As far as we are aware, this is the first study that confirms the presence of four proteins in cat ZP. PMID:25623231

Stetson, I; Avilés, M; Moros, C; García-Vázquez, F A; Gimeno, L; Torrecillas, A; Aliaga, C; Bernardo-Pisa, M V; Ballesta, J; Izquierdo-Rico, M J

2015-04-15

32

A duplicated motif controls assembly of zona pellucida domain proteins  

NASA Astrophysics Data System (ADS)

Many secreted eukaryotic glycoproteins that play fundamental roles in development, hearing, immunity, and cancer polymerize into filaments and extracellular matrices through zona pellucida (ZP) domains. ZP domain proteins are synthesized as precursors containing C-terminal propeptides that are cleaved at conserved sites. However, the consequences of this processing and the mechanism by which nascent proteins assemble are unclear. By microinjection of mutated DNA constructs into growing oocytes and mammalian cell transfection, we have identified a conserved duplicated motif [EHP (external hydrophobic patch)/IHP (internal hydrophobic patch)] regulating the assembly of mouse ZP proteins. Whereas the transmembrane domain (TMD) of ZP3 can be functionally replaced by an unrelated TMD, mutations in either EHP or IHP do not hinder secretion of full-length ZP3 but completely abolish its assembly. Because mutants truncated before the TMD are not processed, we conclude that the conserved TMD of mammalian ZP proteins does not engage them in specific interactions but is essential for C-terminal processing. Cleavage of ZP precursors results in loss of the EHP, thereby activating secreted polypeptides to assemble by using the IHP within the ZP domain. Taken together, these findings suggest a general mechanism for assembly of ZP domain proteins.

Jovine, Luca; Qi, Huayu; Williams, Zev; Litscher, Eveline S.; Wassarman, Paul M.

2004-04-01

33

Survey of zona pellucida antigens for immunocontraception of cats.  

PubMed

The purpose of this study was to screen a panel of native zona pellucida (ZP) antigens isolated from five mammalian species for immunocontraceptive activity in the cat (Felis catus). Native soluble-isolated ZP (SIZP) was prepared from the ovaries of cows (bZP), cats (fZP), ferrets (feZP), dogs (cZP), and mink (mZP). Vaccines were constructed using SIZP from each of the above species encapsulated in liposomes suspended in saline and emulsified with Freund's complete adjuvant (SpayVac). Female cats were immunized once (n = 3 cats per group). Serum was collected for determination of antibody titers against SIZP and for binding of antibodies to feline ovaries. All cats responded to immunization by producing anti-SIZP antibodies. The most immunogenic SIZP in cats was from mink, followed by feZP, cZP, and fZP in descending order. Antibodies had low reactivity for fZP, and no reactivity against feline ovaries was detected by immunohistochemistry. A breeding trial was commenced 20 weeks after immunization. All cats became pregnant, averaging 4.1 +/- 0.7 viable kittens per litter. We have previously shown that porcine SIZP is not an effective antigen for immunocontraception of cats. In this study, SIZP from five other mammalian species were immunogenic in the cat, but ZP antibodies failed to bind to fZP in situ, and fertility was not impeded. PMID:15725441

Levy, Julie K; Mansour, Marc; Crawford, P Cynda; Pohajdak, Bill; Brown, Robert G

2005-03-15

34

Welcome to Zona Land: Education in Physics and Mathematic  

NSDL National Science Digital Library

Zona Land, created by Ed Zobel, is a science and mathematics resource site for students and teachers. The site illustrates mathematical and physical principles by the use of Java applets and VRML simulations. The Science section contains the Physics Department (mechanics, waves and light), EZ Graph, and EZ Evaluator. EZ Graph allows the user to view the graph of a desired function. Evaluator is an online calculator that has trigonometric capabilities. The Mathematics section has four subject areas plus the Graph and Evaluator tools. Graph Paper allows the user to examine the effects of different scales on pre-designed linear, cubic, quadratic, and sine functions. The Function Institute begins with an optional tour of the definition of a function. Also available at the Institute are graphs of linear and polynomial functions. The Geometry Section has three areas of resources: Common Shapes, Fractals, and Coordinate Geometry. Trigonometry Realms has a simple yet comprehensive introduction to trigonometry. Help is available for all of the different resource applications.

Zobel, Edward A.

1998-01-01

35

Boundaries to membranes : the urban project revisited : an urban strategy for Rio de Janeiro, Zona Norte  

E-print Network

This thesis investigates urban boundaries in the North Zone of Rio de Janeiro. The Zona Norte transitioned in the last hundred years from a rural outskirts area of Rio, into its industrial hinterland, into a fully urbanized ...

Dudek, Phebe (Phebe Helena Melania)

2014-01-01

36

PROGRAMACIÓN DEL RIEGO EN CAÑA DE AZÚCAR EN UNA ZONA SEMIÁRIDA DEL ESTADO LARA, VENEZUELA, UTILIZANDO LA METODOLOGÍA FAO56  

Microsoft Academic Search

Daily water balance for sugarcane irrigation scheduling in a semiarid region in Venezuela by using the FAO-56 methodology To optimize the water use efficiency of sugarcane (Saccharum officinarum) grown under sprinkle irrigation in the semiarid region of Lara State, Venezuela, an irrigation program was scheduled based on the daily water balance in the root zone. The FAO-56 methodology was applied

Ricardo Trezza; Yelitza Pacheco; Yamileth Suárez; Aixa Nuñez

2008-01-01

37

Notas sobre la biología y dieta del toyo vieja (Mustelus lunulatus) en la zona central de pesca del Pacífico colombiano  

Microsoft Academic Search

Specimens of Mustelus lunulatus captured in the trawling fishery of a shrimp vessel in the central zone in the Pacific Ocean off Colombia were analyzed. The size, weight, growth pattern, sexual proportion, stages of maturity and diet were determined. The captured specimens were between 50 and 125 cm, the sexual proportion was 1:1, and the isometric-type length-weight relationship was described

Andrés F Navia; Alan Giraldo; Paola A Mejía-Falla

2006-01-01

38

Effects of porcine zona pellucida immunocontraceptives in zoo felids.  

PubMed

Methods of contraception are necessary for management of zoo felids; however, the most commonly used contraceptive (melengestrol acetate implant) is associated with serious adverse reactions with long-term use. Porcine zona pellucida (pZP) vaccines are promising as contraceptives, but their safety in zoo felids has not been tested. pZP vaccine was administered to 27 female felids representing 10 species, including African lion (Panthera leo), Asian leopard (P. pardus), jaguar (P. onca), tiger (P. tigris), snow leopard (P. uncia), cougar (Felis concolor), Siberian lynx (F. lynx), Canada lynx (F. canadensis), serval (F. serval), and bobcat (F. rufus), in 15 facilities. Over 6 wk, each animal received three i.m. injections of 65 microg pZP with Freund's complete adjuvant (FCA), Freund's incomplete adjuvant, or carbopol as the adjuvant. Behavioral signs of estrus were seen in 14 of the vaccinated felids. An unacceptably high incidence of adverse reactions was seen including injection site swelling, lameness, limb swelling, or abscessation (or all) in five felids after injection with FCA as the initial adjuvant. Adverse behavioral signs, including increased irritability and aggression, were seen in four felids. Six of the felids were assayed for antibodies against pZP during the 12 mo after vaccination; all showed antibody production. Antibody levels appeared to peak 1-4 mo after vaccination began, although elevated antibody levels persisted in two animals for > 12 mo after the first injection. All vaccinated felids were ovariohysterectomized 3-13 mo after vaccination. Folliculogenesis was present in all treated animals, and there was no histopathologic evidence of inflammatory damage to ovaries. Contraceptive efficacy was not specifically evaluated in this study; however, two of the three felids housed with an intact male became pregnant during the study, one of which gave birth to healthy cubs. PMID:15526881

Harrenstien, Lisa A; Munson, Linda; Chassy, Lisa M; Liu, Irwin K M; Kirkpatrick, Jay F

2004-09-01

39

Interspecific variation of zona pellucida glycoconjugates in several species of marsupial.  

PubMed

The zona pellucida glycoconjugate content of several marsupial species was investigated using differential lectin histochemistry. Ovaries from fat-tailed dunnarts, a southern brown bandicoot, grey short-tailed opossums, brushtail possums, ringtail possums, koalas and eastern grey kangaroos were fixed, embedded in paraffin wax, sectioned and stained with ten fluorescein isothiocyanate-conjugated lectins. Sections were also incubated with either neuraminidase or saponified, respectively, before incubation with the lectins to identify saccharide residues masked by sialic acids or O-acetyl groups on sialic acids. The zonae pellucidae surrounding the oocytes of the marsupials demonstrated interspecific variation in glycoconjugate content, with mannose-containing glycoconjugates exhibiting the greatest variation. Some of the zona pellucida glycoconjugates of all species, except those of the opossums, were masked by sialic acid with an increase in fluorescence with lectins from Arachis hypogea (PNA), and Glycine max (SBA), after desialylation. The disaccharide beta-galactose(1-4)N-acetyl-D-glucosamine appeared to be conformationally masked by O-acetyl groups of sialic acids in the zonae pellucidae of all species, with an increase in fluorescence with the lectin from Erythrina cristagalli (ECA), after saponification. Similar intensity and localization of beta-(1-4)-N-acetyl-D-glucosamine, as shown by staining of the lectin from Triticum vulgaris (WGA), to the inner and outer regions of the zona pellucida, were found to those reported in eutherian species. WGA fluorescence became uniform throughout the zonae pellucidae after saponification, indicating differential O-acetylation of sialic acids on the internal compartment of the zonae pellucidae. PMID:10864820

Chapman, J A; Wiebkin, O W; Breed, W G

2000-05-01

40

Multiple treatments with SRIH-14 or octreotide affect adrenal zona glomerulosa in adult male rats.  

PubMed

Somatostatin analogues are currently used to treat various disorders such as hypersecretion and different neuroendocrine tumors. In this study we examined the effects on the adrenal cortex of somatostatin (SRIH-14) and octreotide administered subcutaneously twice daily for 5 days to adult male rats. Control rats received saline under the same regime. After sacrifice, the adrenal glands were removed and examined morphometrically using the M(42) multipurpose test system. Blood samples were prepared for biochemical tests. Both SRIH-14 and octreotide induced morphofunctional changes in adrenal zona glomerulosa. We found significant decreases (p < 0.05) in the absolute cell and nuclear volumes of zona glomerulosa in both experimental groups in comparison to the control. The serum aldosterone level was 11% lower (p < 0.05) in the SRIH-14 and 13% (p < 0.05) lower in the octreotide-treated group in comparison with the control group. Morphometric parameters of zona fasciculata and zona reticulata and corticosterone levels were not altered significantly (p > 0.05) in either treated group. It may therefore be concluded that both SRIH-14 and octreotide affected zona glomerulosa in the same manner by decreasing morphofunctional characteristics. PMID:18981530

Trifunovi?, S; Ajdzanovi?, V; Sosi?-Jurjevi?, B; Filipovi?, B; Nestorovi?, N; Sekuli?, M; Milosevi?, V

2008-09-01

41

Globalización y multiculturalismo: ¿son posibles las democracias multiculturales en la era del globalismo?  

Microsoft Academic Search

La globalización y el multiculturalismo son dos realidades relacionadas. El aumento de las desigualdades económicas en el mundo ha conllevado la emigración desde las zonas menos desarrolladas hacia las más prósperas, lo que ha supuesto la llegada a los países occidentales de gentes con diversas culturas. Pero, al mismo tiempo, la globalización, en tanto encarnación del neoliberalismo económico, ha supuesto

Carlos Manuel Abella Vázquez

2007-01-01

42

Análisis económico de los servicios provistos por una plantación forestal: el caso del eucalipto en Chile  

Microsoft Academic Search

En este trabajo se discute el papel que podría cumplir en la zona centro-sur de Chile las plantaciones de eucalipto teniendo en cuenta además de su uso tradicional como fuente de madera, otros usos como como fuente de dendroenergía y del servicio de sumidero de carbono. Para lograr este objetivo se aborda un modelo teórico cuya base es el modelo

Adrián Saldarriaga Isaza; Eric Concha Muñoz

2010-01-01

43

Digitalización de diapositivas del Sol en H ?  

NASA Astrophysics Data System (ADS)

El objetivo de este trabajo ha sido el de obtener imágenes digitalizadas de las diapositivas tomadas del Sol en luz de hidrógeno de la línea correspondiente a H?, y de esta manera llegar a convertir las mismas a un archivo digital para poder ser tratadas luego por computadora y poder contabilizar con exactitud, mediante un programa adecuado para tal fin, las zonas activas del Sol en la imagen digitalizada. En principio, para llegar a esto se pensó en la utilización de medios accesibles, y como detector se utilizó un fototransistor ubicado dentro de un soporte rectangular sobre dos ejes de desplazamiento X e Y. Se han obtenido con este procedimiento imágenes de buena calidad, construídas a partir de tres datos digitalizados en cada barrido que aportan la posición X e Y y la intensidad del pixel en ese punto indicada en 255 tonos de grises.

Missio, H.; Montenegro, C.; Montenegro, R.

44

508 Mastozoologa Neotropical, 2009 por la presencia del bosque nativo y la proteccin  

E-print Network

de la tierra que lo rodean. Las presiones humanas (acceso, protección, densidad de población) tam conservación del paisa- je ecorregional. DENSIDAD, USO DE HÁBITAT Y PRESAS DEL JAGUAR (Panthera onca) Y EL objetivos específicos fueron: 1) estimar la densidad absoluta y distribución de ja- guares por zonas de vida

Nacional Autónoma de México, Universidad

45

Surface alterations of the mouse zona pellucida and ovum following in vivo fertilization: correlation with the cell cycle  

Microsoft Academic Search

The zona pellucida and cell surface of in vivo fertilized mouse ova exhibit time dependent changes which can be detected with the scanning electron microscope. The periods of ovulation, fertilization and first cleavage in superovulated C3D2\\/F⁠hybrids were determined and times corresponding to Gâ, S, Gâ, and M were calculated. The zona of a mature unfertilized ovum has a rough

S. Jackowski; J. N. Dumont

1979-01-01

46

Vitellogenin and zona radiata proteins as biomarkers of endocrine disruption in peregrine falcon ( Falco peregrinus)  

Microsoft Academic Search

The aim of this study was to test a specific method for the detection of Vitellogenin (Vtg) and Zona Radiata Proteins (Zrp) in plasma from peregrine falcon (Falco peregrinus) as specific biomarkers for the evaluation of the effects of endocrine disruptors. The method was assayed with different peregrine falcon individuals (including mature and immature birds of both sexes) from a

Begoña Jiménez; Gabriele Mori; Miguel A. Concejero; Rubén Merino; Silvia Casini; María Cristina Fossi

2007-01-01

47

Role of the follicle in zona pellucida maturation of hamster oocyte  

E-print Network

Role of the follicle in zona pellucida maturation of hamster oocyte Jacqueline MANDELBAUM Michèle. Hamster oocytes matured in vitro are not fer- tilizable (Mandelbaum and Plachot, 1977). When immature). In this report, we re-investigate hamster oocyte maturation, comparing extra- and intrafollicular maturations

Paris-Sud XI, Université de

48

Effect of IVF and laser zona dissection on DNA methylation pattern of mouse zygotes  

E-print Network

2009 Ã? Springer Science+Business Media, LLC 2009 Abstract In vitro fertilization (IVF) and zona fertilized in vitro with freshly collected spermatozoa. Zygotes were fixed 5, 8, and 12 h after fertilization spermatozoa and in vitro fertilization or thawed embryos and embryo transfer (Marschall et al. 1999). In vitro

Rodenacker, Karsten

49

CYTOLOGICAL ALTERATIONS RELATED TO STIMULATION OF THE ZONA GLOMERULOSA OF THE ADRENAL GLAND  

Microsoft Academic Search

The structure of the zona glomerulosa of the rat adrenal gland stimulated by sodium re- striction has been studied by light and electron microscopy. The major changes observed during the course of the experiment in stimulated glands involve cytoplasmic droplets, mitochondria, and the endoplasmic reticulum. There is a progressive decrease in the number of cytoplasmic droplets of low electron opacity.

FILIBERTO GIACOMELLI; JOSEPH WIENER; DAVID SPIRO

2010-01-01

50

ADRENIC ACID METABOLITES AS ENDOGENOUS ENDOTHELIUM- AND ZONA GLOMERULOSA-DERIVED HYPERPOLARIZING FACTORS  

PubMed Central

Adrenic acid (docosatetraenoic acid), an abundant fatty acid in the adrenal gland, is identical to arachidonic acid except for two additional carbons on the carboxyl end. Adrenic acid is metabolized by cycloxygenases, cytochrome P450s, and lipoxygenases; however, little is known regarding the role of adrenic acid and its metabolites in vascular tone. Due to its abundance in the adrenal gland, we investigated the role of adrenic acid in vascular tone of bovine adrenal cortical arteries and its metabolism by bovine adrenal zona glomerulosa cells. In adrenal cortical arteries, adrenic acid caused concentration-dependent relaxations, which were inhibited by the epoxyeicosatrienoic acid antagonist 14,15-epoxyeicosa-5(Z)-enoic acid and the cytochrome 450 inhibitor SKF-525A. The large-conductance calcium-activated potassium channel channel blocker iberiotoxin or removal of the endothelium abolished these relaxations. Reverse-phase high-pressure liquid chromatography and liquid chromatography/mass spectrometry isolated and identified numerous adrenic acid metabolites from zona glomerulosa cells including dihomo-epoxyeicosatrienoic acids and dihomo-prostaglandins. In denuded adrenal cortical arteries, adrenic acid caused concentration-dependent relaxations in the presence of zona glomerulosa cells but not in their absence. These relaxations were inhibited by SKF-525A, 14,15-epoxyeicosa-5(Z)-enoic acid, and iberiotoxin. Dihomo-16,17-epoxyeicosatrienoic acid caused concentration-dependent relaxations of adrenal cortical arteries, which were inhibited by 14,15-epoxyeicosa-5(Z)-enoic acid and high potassium. Our results suggest that adrenic acid relaxations of bovine adrenal cortical arteries are mediated by endothelial and zona glomerulosa cell cytochrome P450 metabolites. Thus, adrenic acid metabolites could function as endogenous endothelium- and zona glomerulosa-derived hyperpolarizing factors in the adrenal cortex and contribute to the regulation of adrenal blood flow. PMID:20038752

Kopf, Phillip G.; Zhang, David X.; Gauthier, Kathryn M.; Nithipatikom, Kasem; Falck, John R.; Campbell, William B.

2010-01-01

51

Degradación de Marismas Costera: el Impacto de la Eutrofización en la Supervivencia del las Marismas Costeras en New England y Central California, USA. (Salt Marsh Deterioration in New England and Central California: Impacts of Eutrophication on Salt Marsh Survival.)  

EPA Science Inventory

Las marismas costeras proporcionan numerosos beneficios a los ecosistemas, incluyendo la proporción del hábitat de la flora y fauna, la protección de las zonas costeras contra inundaciones durante eventos extremos, mejoran la calidad del agua para las almejas y ostras a través de...

52

El uso de la neuromodulación para el tratamiento del temblor  

PubMed Central

Introducción: El temblor puede ser un desorden incapacitante y el tratamiento de primera línea para estos pacientes es farmacológico. Sin embargo, este tratamiento puede llevar a una reducción satisfactoria del temblor en sólo el 50% de los pacientes con temblor esencial. La talamotomía era el tratamiento de elección para el temblor refractario al tratamiento médico hasta que comenzó a utilizarse la estimulación cerebral profunda (ECP) del núcleo ventral intermedio (Vim) del tálamo. En la actualidad, raramente se realiza la talamotomía. Métodos: Este artículo es una revisión no sistemática de las indicaciones, resultados, parámetros de programación y técnica quirúrgica de la ECP del Vim para el tratamiento del temblor. Resultados: Aunque los resultados clínicos son similares usando la talamotomía o la ECP del Vim, la primera causa más efectos adversos que la última. Además, la ECP puede ser usada bilateralmente, mientras que la talamotomía tiene un alto riesgo de causar disartria cuando se realiza de ambos lados. La ECP del Vim logró una adecuada mejoría del temblor en varias series de pacientes con temblor causado por temblor esencial, enfermedad de Parkinson o esclerosis múltiple. Además del Vim, hay otros blancos que están siendo usados por varios autores, tales como la zona incerta y las radiaciones prelemniscales. Conclusión: La ECP del Vim es un tratamiento útil para el temblor incapacitante refractario al tratamiento médico. Es esencial realizar una precisa selección de pacientes, así como utilizar una técnica quirúrgica correcta. Aún se desconoce el mejor blanco estereotáctico para el temblor, aunque el Vim es el más usado. PMID:25165613

Bendersky, Damián; Ajler, Pablo; Yampolsky, Claudio

2014-01-01

53

Estimación del flujo superficial de metano (CH 4 ) en las emisiones del biogás desde la zona VII del relleno sanitario de Doña Juana  

Microsoft Academic Search

Sanitary landfills are recognized as globally significant sources of atmospheric methane, but field measurements of this gas are limited. Methane (CH4) emissions were measured using a closed chamber technique at the Doña Juana sanitary landfill from zone VII located in south of Bogotá city. Overall, ob- served superficial methane flux from 61 to 474 mmol\\/m 2 -h. Fluxs were related

M. P. Manosalva

54

Sincronización de la intensidad del comercio internacional y el ciclo económico: ¿Hay alguna diferencia en los países en desarrollo?  

Microsoft Academic Search

(Disponible en idioma inglés únicamente) Algunos criterios claves de la obra publicada sobre la zona monetaria óptima son que los países deben sumarse a una unión monetaria para poder establecer lazos comerciales internacionales más estrechos y ciclos económicos más simétricos. Pero ambos criterios son endógenos. Frankel y Rose (1998) hallan que la intensidad del comercio hace aumentar la correlación entre

César Calderón; Alberto Chong; Ernesto H. Stein

2003-01-01

55

Microencapsulation of single, multiple, and zona pellucida-free mouse preimplantation embryos in sodium alginate and their development in vitro.  

PubMed

Preimplantation embryos obtained from immature superovulated B6D2F1 female mice were microencapsulated in sodium alginate singly, in multiples of 2 or 3, or denuded of their zona pellucida. Encapsulated embryos developed in vitro at a rate similar to control embryos. Development of zona pellucida-free embryos was significantly less than that of intact embryos, but there was no difference between encapsulated and non-encapsulated zona pellucida-free embryos. Development of 2- and 4-cell embryos in sodium alginate was independent of cell stage. This report demonstrates the usefulness of a viable, biodegradable embedding material for the microencapsulation of manipulated preimplantation mammalian embryos. PMID:2231540

Cosby, N C; Dukelow, W R

1990-09-01

56

Retinal projections into the Zona Incerta of the rock cavy (Kerodon rupestris): a CTb study.  

PubMed

The Zona Incerta is a key neural substrate of higher brain functions. A neural population in the caudal ZI projects into the superior colliculus. This recently has been identified as an important structure for the saccades. Applying CTb, we describe a retinal projection into the caudal ZI and the distribution of its terminal varicosities in the rock cavy, a Brazilian rodent, which has been used as an anatomical model to enhance the comprehension about the phylogeny of the nervous system. Contrary to other investigated rodents, the retinal fibers in the rock cavy lie in the caudal Zona Incerta (ZIc), suggesting a functional specialization in the rock cavy. The high resolution and qualitative analysis of retinal fibers in the present work provide a substrate to interpretation of the visual system, and its phylogenetic pathways among species. PMID:25242576

de Góis Morais, Paulo Leonardo Araújo; de Santana, Melquisedec Abiaré Dantas; Cavalcante, Judney Cley; de Oliveira Costa, Miriam Stela Maris; Sousa Cavalcante, Jeferson; do Nascimento, Expedito Silva

2014-12-01

57

Ejaculate-hormonal traits in the leopard cat (Felis bengalensis) and sperm function as measured by in vitro penetration of zona-free hamster ova and zona-intact domestic cat oocytes  

Microsoft Academic Search

Electroejaculate traits and cir- culating follicle-stimulating hormone (FSH), lutein- izing hormone (LhH), and testosterone concentra- tions were analyzed in adult leopard cats {Fells bengalensis), a rare felid species indigenous to east Asia. The ability of leopard cat sperm to bind and penetrate zona-free hamster ova and zona- intact domestic cat oocytes in vitro was examined as a means of testing

Jogayle Howard; David E. Wildt

1990-01-01

58

The zona pellucida of the koala (Phascolarctos cinereus): its morphogenesis and thickness  

PubMed Central

In this study the ultrastructural organization of the koala oocyte and the thickness of the surrounding extracellular coat, the zona pellucida, has been determined to ascertain whether there is coevolution of the morphology of the female gamete with that of the highly divergent male gamete that is found in this marsupial species. Ovaries from several adult koalas were obtained and prepared for transmission electron microscopy. Oocytes in large tertiary follicles were somewhat smaller than those of most other marsupials, although their ultrastructural organization appeared similar and included many yolk vesicles. The zona pellucida surrounding the oocytes in tertiary follicles was approximately 8 µm thick and thus is of similar thickness to that of some eutherian mammals but at least twice as thick as that of most marsupial species so far studied. The results indicate that the koala oocyte is unusually small for a marsupial species whereas the zona pellucida is, by contrast, much thicker. How this relates to sperm–egg interaction at the time of fertilization has yet to be determined. PMID:16928207

Chapman, Jamie A; Leigh, Christopher M; Breed, William G

2006-01-01

59

Modifications to improve the efficiency of zona-free mouse nuclear transfer.  

PubMed

In the present study, some modifications were made to the zona-free nuclear transfer technique in the mouse in order to achieve greater efficiency. Firstly, a 1-h interval was allowed between cumulus removal and zona pellucida digestion. Secondly, acid Tyrode's was selected for zona pellucida removal, because contrary to pronase, it allows embryo survival during parthenogenic activation in the absence of calcium. Even when the exposure time to pronase was reduced to as little as 1 min or washed with fetal calf serum to inhibit the enzyme, the percentage of lysis during activation in the absence of calcium was still very high. Thirdly, electrofusion was performed at room temperature (21 degrees C), instead of 30 degrees C as in our previous experiments. Finally, embryos were cultured in groups of 12-15, instead of individually, using a "well of the wells" system during activation and culture. When compared, parthenogenic activated control embryos showed an increase in the development to blastocyst when cultured in pairs instead of individually. By the end of the experiments and using embryonic stem (ES) cells, there was a significant increase in fusion rate (1.5-fold increase) and in development to morula/blastocyst from cleaved reconstructed embryos (1.5-fold increase) when compared with the results before the modifications. A 2.4-fold increase in overall efficiency was achieved from the oocyte to morula/blastocyst stages. PMID:16571073

Ribas, R; Oback, B; Ritchie, W; Chebotareva, T; Taylor, J; Maurício, A C; Sousa, M; Wilmut, I

2006-01-01

60

Thermal effects in laser-assisted pre-embryo zona drilling  

NASA Astrophysics Data System (ADS)

Diode lasers ((lambda) equals 1480 nm) are used with in vitro fertilization to dissect the zone pellucida (shell) of pre- embryos. A focused laser beam is applied in vitro to form a channel or trench in the zona pellucida. The procedure is used to facilitate biopsy or as a promoter of embryo hatching. We present examples and measurements of zona pellucida ablation using animal models. In using the laser it is vital not to damage pre-embryo cells, e.g., by overheating. In order to define safe regimes we have derived some thermal side effects of zona pellucida removal. The temperature profile in the beam and vicinity is predicted as function of laser pulse duration and power. In a crossed- beam experiment a HeNe laser probe is used to detect the temperature-induced change in the refractive index of an aqueous solution, and estimate local thermal gradient. We find that the diode laser beam produces superheated water approaching 200 degree(s)C on the beam axis. Thermal histories during and following the laser pulse are given for regions in the neighborhood of the beam. We conclude that an optimum regime exists with pulse duration

Douglas-Hamilton, Diarmaid H.; Conia, Jerome D.

2001-04-01

61

Sperm proteasomes degrade sperm receptor on the egg zona pellucida during mammalian fertilization.  

PubMed

Despite decades of research, the mechanism by which the fertilizing spermatozoon penetrates the mammalian vitelline membrane, the zona pellucida (ZP) remains one of the unexplained fundamental events of human/mammalian development. Evidence has been accumulating in support of the 26S proteasome as a candidate for echinoderm, ascidian and mammalian egg coat lysin. Monitoring ZP protein degradation by sperm during fertilization is nearly impossible because those few spermatozoa that penetrate the ZP leave behind a virtually untraceable residue of degraded proteins. We have overcome this hurdle by designing an experimentally consistent in vitro system in which live boar spermatozoa are co-incubated with ZP-proteins (ZPP) solubilized from porcine oocytes. Using this assay, mimicking sperm-egg interactions, we demonstrate that the sperm-borne proteasomes can degrade the sperm receptor protein ZPC. Upon coincubation with motile spermatozoa, the solubilized ZPP, which appear to be ubiquitinated, adhered to sperm acrosomal caps and induced acrosomal exocytosis/formation of the acrosomal shroud. The degradation of the sperm receptor protein ZPC was assessed by Western blotting band-densitometry and proteomics. A nearly identical pattern of sperm receptor degradation, evident already within the first 5 min of coincubation, was observed when the spermatozoa were replaced with the isolated, enzymatically active, sperm-derived proteasomes. ZPC degradation was blocked by proteasomal inhibitors and accelerated by ubiquitin-aldehyde(UBAL), a modified ubiquitin protein that stimulates proteasomal proteolysis. Such a degradation pattern of ZPC is consistent with in vitro fertilization studies, in which proteasomal inhibitors completely blocked fertilization, and UBAL increased fertilization and polyspermy rates. Preincubation of intact zona-enclosed ova with isolated active sperm proteasomes caused digestion, abrasions and loosening of the exposed zonae, and significantly reduced the fertilization/polyspermy rates after IVF, accompanied by en-mass detachment of zona bound sperm. Thus, the sperm borne 26S proteasome is a candidate zona lysin in mammals. This new paradigm has implications for contraception and assisted reproductive technologies in humans, as well as animals. PMID:21383844

Zimmerman, Shawn W; Manandhar, Gaurishankar; Yi, Young-Joo; Gupta, Satish K; Sutovsky, Miriam; Odhiambo, John F; Powell, Michael D; Miller, David J; Sutovsky, Peter

2011-01-01

62

Laser-assisted zona pellucida thinning does not facilitate hatching and may disrupt the in vitro hatching process: a morphokinetic study in the mouse  

PubMed Central

STUDY QUESTION Does laser-assisted zona thinning of cleavage stage mouse embryos facilitate hatching in vitro? SUMMARY ANSWER No, unlike laser zona opening, zona thinning does not facilitate embryo hatching. WHAT IS KNOWN ALREADY Artificial opening of the zona pellucida facilitates hatching of mouse and human embryos. Laser-assisted zona thinning has also been used for the purpose of assisted hatching of human embryos but it has not been properly investigated in an animal model; thinning methods have produced inconsistent clinical results. STUDY DESIGN, SIZE, DURATION Time-lapse microscopy was used to study the hatching process in the mouse after zona opening and zona thinning; a control group of embryos was not zona-manipulated but exposed to the same laser energy. PARTICIPANTS/MATERIALS, SETTING, METHODS Eight-cell CB6F1/J mouse embryos were pooled and allocated to three groups (n = 56 per group): A control group of embryos that were exposed to a dose of laser energy focused outside the zona pellucida (zona intact); one experimental group of embryos in which the zona pellucida was opened by complete ablation using the same total number of pulses as the control group; a second experimental group of embryos in which the zona pellucida was thinned to establish a smooth lased area using the same number of pulses as used in the other two groups. The width of the zona opening was 25 ?m and width of the thinned area was 35 ?m. Development was monitored by time-lapse microscopy. Overall treatment differences for continuous variables were analyzed by analysis of variance and pairwise comparisons using the Student t-test allowing for unequal variances, while for categorical data, a standard chi-squared test was utilized for all pairwise comparisons. MAIN RESULTS AND THE ROLE OF CHANCE The frequency of complete hatching was 33.9% in the control group, 94.4% after zona opening, and 39.3% after zona thinning (overall group comparison, P < 0.0001). Overall, 60.7% of the zona-thinned embryos did not complete the hatching process and remained trapped within the zona; when they did hatch, they did not necessarily hatch from the zona-thinned area. Hatching in about one-third of the zona-intact embryos began with breaches at multiple sites by small groups of cells. Likewise, 53.6% of zona-thinned embryos had multiple breaches, always involving an area outside the thinned zone. Zona opening decreased multiple breaching and led to blastocyst escape an average of 14 h earlier than zona-thinned embryos and 5.5 h before control embryos (P = 0.0003). LIMITATIONS, REASONS FOR CAUTION The experiments presented here were limited to in vitro experiments performed in the mouse. Whether human embryos would behave the same way under similar circumstances is unknown. We postulate that zona thinning is not beneficial in human embryos. WIDER IMPLICATIONS OF THE FINDINGS The experiments demonstrate that zona thinning is not equivalent to zona opening for assisted hatching. The study provides reason for systematic reviews of assisted hatching trials to take the method of assisted hatching into consideration and not combine the results of zona thinning and zona opening procedures. STUDY FUNDING/COMPETING INTEREST(S) Institutional funds were used for the study. No competing interests are declared. PMID:25267786

Schimmel, Tim; Cohen, Jacques; Saunders, Helen; Alikani, Mina

2014-01-01

63

Clinical, Biochemical, and Molecular Characterization of Macronodular Adrenocortical Hyperplasia of the Zona Reticularis: A New Syndrome  

PubMed Central

Context: Macronodular adrenocortical hyperplasia classically presents with progressive hypercortisolemia and Cushing syndrome. We describe a 29-yr-old man with massive macronodular adrenocortical hyperplasia without hypercortisolemia but rather markedly elevated and nonsuppressible production of dehydroepiandrosterone (DHEA) and its sulfate (DHEAS). Objective: To characterize the clinical and molecular features of this case and to determine whether the tissue biochemically resembles the zona reticularis or fetal adrenal. Setting: University clinic, hospital, and laboratories. Design: Static and dynamic blood and urine testing were performed preoperatively. Tissue was studied by light microscopy, immunoblot, RNA microarray, and enzyme assay. Participant: A 29-yr-old man with incidentally discovered bilateral adrenal enlargement. Intervention: Bilateral adrenalectomy. Main Outcome Measures: Molecular studies compared with control samples. Results: Hypercortisolism and 21-hydroxylase deficiency were excluded. DHEA, DHEAS, and 17-hydroxypregnenolone were markedly elevated and did not suppress with dexamethasone 2 mg/d for 4 d. Homogenates of the adrenals demonstrated high 17-hydroxylase, good 17,20-lyase, and low or absent 21-hydroxylase and 3?-hydroxysteroid dehydrogenase activities. Immunoblots confirmed robust expression of cytochrome P450c17 and AKR1C3 but not P450c21. Microarray analysis demonstrated high CYP11A1 and CYP17A1 expression but low or absent HSD3B1, HSD3B2, and CYP21A2 expression. Expression of mRNA for cytochrome b5 (CYB5A) and AKR1C3, markers of the zona reticularis, were markedly elevated. Conclusion: This is the first case of macronodular hyperplasia of the adrenal zona reticularis confirmed with studies of enzyme activity, mRNA expression, and protein identification. We speculate that this condition can be clinically silent in men but might cause severe hyperandrogenemia in women. PMID:21084398

Ghayee, Hans K.; Rege, Juilee; Watumull, Lori M.; Nwariaku, Fiemu E.; Carrick, Kelley S.; Rainey, William E.; Miller, Walter L.

2011-01-01

64

'ZP domain' of human zona pellucida glycoprotein-1 binds to human spermatozoa and induces acrosomal exocytosis  

PubMed Central

Background The human egg coat, zona pellucida (ZP), is composed of four glycoproteins designated as zona pellucida glycoprotein-1 (ZP1), -2 (ZP2), -3 (ZP3) and -4 (ZP4) respectively. The zona proteins possess the archetypal 'ZP domain', a signature domain comprised of approximately 260 amino acid (aa) residues. In the present manuscript, attempts have been made to delineate the functional significance of the 'ZP domain' module of human ZP1, corresponding to 273-551 aa fragment of human ZP1. Methods Baculovirus-expressed, nickel-nitrilotriacetic acid affinity chromatography purified 'ZP domain' of human ZP1 was employed to assess its capability to bind and subsequently induce acrosomal exocytosis in capacitated human spermatozoa using tetramethyl rhodamine isothiocyanate conjugated Pisum sativum Agglutinin in absence or presence of various pharmacological inhibitors. Binding characteristics of ZP1 'ZP domain' were assessed employing fluorescein isothiocyanate (FITC) labelled recombinant protein. Results SDS-PAGE and immunoblot characterization of the purified recombinant protein (both from cell lysate as well as culture supernatant) revealed a doublet ranging from ~35-40 kDa. FITC- labelled 'ZP domain' of ZP1 binds primarily to the acrosomal cap of the capacitated human spermatozoa. A dose dependent increase in acrosomal exocytosis was observed when capacitated sperm were incubated with recombinant 'ZP domain' of human ZP1. The acrosome reaction mediated by recombinant protein was independent of Gi protein-coupled receptor pathway, required extra cellular calcium and involved both T- and L-type voltage operated calcium channels. Conclusions Results described in the present study suggest that the 'ZP domain' module of human ZP1 has functional activity and may have a role during fertilization in humans. PMID:20831819

2010-01-01

65

Native zona pellucida reactivity and in-vitro effect on human sperm–egg binding with antisera against bonnet monkey ZP1 and ZP3 synthetic peptides  

Microsoft Academic Search

In mammals, zona pellucida glycoprotein-3 (ZP3) is the putative ligand for primary sperm binding and induces the acrosome reaction. Recent evidence suggests that zona pellucida glycoprotein-1 (ZP1) also play an important role, in some species, during fertilization. In order to identify synthetic peptide immunogens capable of inducing antibodies reactive with native zona and inhibiting sperm–oocyte interaction, peptide encompassing the amino

Neela Sivapurapu; Abhishek Upadhyay; Akiko Hasegawa; Koji Koyama; Satish K Gupta

2002-01-01

66

Effect of fertility regulating agents on motility and zona-free hamster egg penetration by spermatozoa of bonnet monkey.  

PubMed

Administration of STS-557 (17 alpha-cyanomethyl-17 beta-hydroxyestra 4,9(10)-dien-3-one; 12 mg/monkey daily) for 4 weeks either alone or in combination with 20 Aet-1 (testosterone-trans-4-n-butyl cyclohexyl carboxylate; code CDB 1781; 40 mg/monkey single administration) had no significant effect on motility and zona free hamster egg penetration by spermatozoa of bonnet monkey, but continuation of the treatment for 12 weeks reduced (in one monkey treated with STS-557) or abolished (one treated with STS-557 and two with STS-557 + 20 Aet-1) the motility as well as zona-free hamster egg penetration (by spermatozoa of all treated monkeys). Motility and the ability to penetrate zona-free hamster egg returned to normalcy after 10 weeks of withdrawal of treatments. Active immunization of monkeys with ovine FSH (4 weeks after booster) had no adverse effect on motility of spermatozoa but none of the zona-free hamster eggs was fertilized. The correlation between motility and the capacity to penetrate the zona-free hamster eggs by monkey spermatozoa varies with the treatment. Such correlation was apparent in monkeys treated with STS-557 but not in monkeys immunized with ovine FSH. PMID:1293043

Sharma, R K; Das, R P

1992-11-01

67

Human sperm bind to the N-terminal domain of ZP2 in humanized zonae pellucidae in transgenic mice  

PubMed Central

Fertilization requires taxon-specific gamete recognition, and human sperm do not bind to zonae pellucidae (ZP1–3) surrounding mouse eggs. Using transgenesis to replace endogenous mouse proteins with human homologues, gain-of-function sperm-binding assays were established to evaluate human gamete recognition. Human sperm bound only to zonae pellucidae containing human ZP2, either alone or coexpressed with other human zona proteins. Binding to the humanized matrix was a dominant effect that resulted in human sperm penetration of the zona pellucida and accumulation in the perivitelline space, where they were unable to fuse with mouse eggs. Using recombinant peptides, the site of gamete recognition was located to a defined domain in the N terminus of ZP2. These results provide experimental evidence for the role of ZP2 in mediating sperm binding to the zona pellucida and support a model in which human sperm–egg recognition is dependent on an N-terminal domain of ZP2, which is degraded after fertilization to provide a definitive block to polyspermy. PMID:22734000

Baibakov, Boris; Boggs, Nathan A.; Yauger, Belinda; Baibakov, Galina

2012-01-01

68

A single domain of the ZP2 zona pellucida protein mediates gamete recognition in mice and humans  

PubMed Central

The extracellular zona pellucida surrounds ovulated eggs and mediates gamete recognition that is essential for mammalian fertilization. Zonae matrices contain three (mouse) or four (human) glycoproteins (ZP1–4), but which protein binds sperm remains controversial. A defining characteristic of an essential zona ligand is sterility after genetic ablation. We have established transgenic mice expressing human ZP4 that form zonae pellucidae in the absence of mouse or human ZP2. Neither mouse nor human sperm bound to these ovulated eggs, and these female mice were sterile after in vivo insemination or natural mating. The same phenotype was observed with truncated ZP2 that lacks a restricted domain within ZP251–149. Chimeric human/mouse ZP2 isoforms expressed in transgenic mice and recombinant peptide bead assays confirmed that this region accounts for the taxon specificity observed in human–mouse gamete recognition. These observations in transgenic mice document that the ZP251–149 sperm-binding domain is necessary for human and mouse gamete recognition and penetration through the zona pellucida. PMID:24934154

Avella, Matteo A.; Baibakov, Boris

2014-01-01

69

Adrenocortical zonation results from lineage conversion of differentiated zona glomerulosa cells  

PubMed Central

Summary Lineage conversion of differentiated cells in response to hormonal feedback has yet to be described. To investigate this we studied the adrenal cortex, which is composed of functionally distinct concentric layers that develop postnatally, the outer zona Glomerulosa (zG) and the inner zona Fasiculata (zF). These layers have separate functions, are continuously renewed in response to physiological demands and are regulated by discrete hormonal feedback loops. Their cellular origin, lineage relationship and renewal mechanism, however, remain poorly understood. Cell fate mapping and gene deletion studies using zG-specific Cre expression demonstrate that differentiated zG cells undergo lineage conversion into zF cells. In addition, zG maintenance is dependent on the master transcriptional regulator Steroidogenic Factor 1 (SF-1) and zG-specific Sf-1 deletion prevents lineage conversion. These findings demonstrate that adrenocortical zonation and regeneration result from lineage conversion and may provide a paradigm for homeostatic cellular renewal in other tissues. PMID:24035414

Carlone, Diana L.; Shah, Manasvi; Guagliardo, Nick A.; Barrett, Paula Q.; Gomez-Sanchez, Celso E.; Majzoub, Joseph A.; Breault, David T.

2013-01-01

70

A study of the zona piercing process in piezodriven intracytoplasmic sperm injection  

NASA Astrophysics Data System (ADS)

The mouse zona piercing process in piezodriven intracytoplasmic sperm injection (piezo-ICSI) is modeled and simulated with the material point method (MPM) to study the physics behind the piercing process. The MPM simulation reveals that the lateral vibration of the injection pipette plays a key role in the piercing process and disproves the claim that the axial displacement of the pipette pierces the zona. The lateral vibration of the injection pipette is further analyzed using the finite element method to investigate the role of mercury in the piercing process. It is shown that the use of mercury generally reduces the amplitude of the pipette tip and that a shorter piezopulse duration results in a smaller vibration amplitude. This implies that the effect of mercury on the piezo-ICSI procedure may lie in causing less oocyte damage due to the reduced amplitude of the pipette tip, and the development of a piezo-ICSI procedure without using mercury is possible by changing the dimensions of the injection micropipette and the piezodrill controller parameters.

Gan, Yong; Chen, Zhen

2008-08-01

71

Imaging the zona pellucida of canine and feline oocytes using scanning electron microscopy.  

PubMed

Ultrastructure of the zona pellucida (ZP) of canine and feline oocytes has not been fully investigated. The objective of the study was to evaluate the potential use of the low vacuum scanning electron microscope (LVSEM) with oocytes. This required development of a method to prepare canine and feline cumulus-oocyte complexes (COCs) for LVSEM to provide ultrastructural information on the ZP. COCs were collected from ovaries, and cumulus cells were either partially or completely removed to reveal the ZP. COCs and zona-intact oocytes were fixed at 4 degrees C for 1 h in 2.5% glutaraldehyde in 0.1 M sodium cacodylate buffer, pH 7.4 and subsequently viewed wet or further processed by critical point drying, and viewed uncoated or sputter coated with gold. Although the spongy surface of the ZP was visible at low vacuum in uncoated oocytes, coated oocytes had more details at high vacuum. The ZP surface of canine and feline oocytes contained numerous various-sized, spherical or elliptical pores that narrowed centripetally splitting into several smaller, deep pores. The round to oblong cumulus cells tightly surrounded the ZP. Each corona radiata cumulus cell tapered into a thin projection that entered the ZP. Our detailed techniques will enable future studies connecting ultrastructural and molecular aspects of oocyte maturation and development in mammals. PMID:19144252

Lunn, Matthew O; Wright, Shirley J

2009-02-01

72

Structural Analysis of Peptide-Analogues of Human Zona Pellucida ZP1 Protein with Amyloidogenic Properties: Insights into Mammalian Zona Pellucida Formation  

PubMed Central

Zona pellucida (ZP) is an extracellular matrix surrounding and protecting mammalian and fish oocytes, which is responsible for sperm binding. Mammalian ZP consists of three to four glycoproteins, called ZP1, ZP2, ZP3, ZP4. These proteins polymerize into long interconnected filaments, through a common structural unit, known as the ZP domain, which consists of two domains, ZP-N and ZP-C. ZP is related in function to silkmoth chorion and in an evolutionary fashion to the teleostean fish chorion, also fibrous structures protecting the oocyte and embryo, that both have been proven to be functional amyloids. Two peptides were predicted as ‘aggregation-prone’ by our prediction tool, AMYLPRED, from the sequence of the human ZP1-N domain. Here, we present results from transmission electron microscopy, X-ray diffraction, Congo red staining and attenuated total reflectance Fourier-transform infrared spectroscopy (ATR FT-IR), of two synthetic peptide-analogues of these predicted ‘aggregation-prone’ parts of the human ZP1-N domain, that we consider crucial for ZP protein polymerization, showing that they both self-assemble into amyloid-like fibrils. Based on our experimental data, we propose that human ZP (hZP) might be considered as a novel, putative, natural protective amyloid, in close analogy to silkmoth and teleostean fish chorions. Experiments are in progress to verify this proposal. We also attempt to provide insights into ZP formation, proposing a possible model for hZP1-N domain polymerization. PMID:24069181

Louros, Nikolaos N.; Iconomidou, Vassiliki A.; Giannelou, Polina; Hamodrakas, Stavros J.

2013-01-01

73

Boletín del Instituto Nacional del Cáncer  

Cancer.gov

La edición electrónica del Boletín del Instituto Nacional del Cáncer se publicó mensualmente desde septiembre de 2009 hasta enero de 2013, con el objetivo de difundir información sobre la investigación del cáncer, tanto de estudios financiados por el NCI y otras dependencias federales, así como de investigaciones realizadas por instituciones en Estados Unidos y alrededor del mundo.

74

Differential binding of X- and Y-chromosome-bearing human spermatozoa to zona pellucida in vitro.  

PubMed

The sex of human offspring has been associated with the day in the mother's menstrual cycle on which insemination occurs, with male zygotes being formed earlier in the fertile period than female zygotes. Using an in vitro environment designed to mimic the in vivo milieu, we tested the hypothesis that Y-chromosome-bearing spermatozoa survive functionally longer than X-chromosome-bearing spermatozoa, and that this differential functional survival is a contributing factor to the in vivo phenomenon. Donor semen was processed by swim-up and incubated at 37 degrees C in culture medium for 0, 24 and 48 h, with human zona pellucida (hemizona, HZ) being used to select functional spermatozoa. A second set of in vitro storage conditions, 4 degrees C in test-yolk refrigeration buffer, was used to determine whether changing the incubation conditions alters the process. The sex chromosome of the spermatozoa was determined using fluorescent in situ hybridization (FISH). For spermatozoa incubated at 37 degrees C, the percentage of functional (HZ bound) Y-bearing spermatozoa was significantly increased (P < 0.05) at 48 h (55.4 + 2.9%) but not at 0 h (50.5 + 0.7%) or 24 h (52.8 + 3.1%) compared to swim-up spermatozoa (50.6 + 0.3%). No difference in the percentage of functional Y-spermatozoa was observed at any time-point with storage at 4 degrees C in refrigeration buffer. Thus, we demonstrated that significantly more Y-bearing spermatozoa were capable of zona binding than X-bearing spermatozoa at 48 h at 37 degrees C incubation, with an observed Y : X ratio of 1.15 for these zona-bound spermatozoa compared to 1.02 for post-swim-up spermatozoa. We conclude that a differential functional survival appears to exist between X-bearing and Y-bearing spermatozoa, with the latter exhibiting a longer functional survival under in vitro conditions. PMID:11472331

Van Dyk, Q; Mahony, M C; Hodgen, G D

2001-07-01

75

The Use of Zona-Free Animal Ova as a Test-System for the Assessment of the Fertilizing Capacity of Human Spermatozoa  

Microsoft Academic Search

Human spermatozoa are initially incapable of penetrating zona pellucida-free animal (hamster) ova but gain the ability to do so when incubated several hours in vitro. Experimental evidence sug- gests that this ability is associated with the completion of sperm capacitation and the acrosome reaction. Thus it appears that zona-free animal ova can be substituted for human ova in the prelim-

R. YANAGIMACHI; H. YANAGIMACHI; B. J. ROGERS

1976-01-01

76

Microestructura y propiedades mecánicas de conductores protónicos de alta temperatura crecidos por fusión de zona flotante  

Microsoft Academic Search

Se han estudiado conductores protónicos de alta temperatura (CPAT) fabricados por fusión de zona flotante asistida por láser (SrCe 0.9Y0.1O3-?, SrCe0.8Y0.2O3-?, SrZr0.9Y0.1O3-?, SrZr0.8Y0.2O3-?, Sr3(Ca1.18Nb1.82)O9-? y SrTi0.95Sc0.05O3-?). La caracterización microestructural se ha realizado mediante Microscopía Electrónica de Barrido y Transmisión (MEB, MET). Los materiales tienen una estructura celular, con células de anchuras entre 10-50 µm y regiones intercelulares superiores a 1

M. J. López RobLedo; A. SA

77

Specific antibodies to porcine zona pellucida detected by quantitative radioimmunoassay in both fertile and infertile women  

SciTech Connect

The specific radioimmunoassay system was developed for the titration of the antibodies to porcine zona pellucida (ZP) in human sera by using /sup 125/I-labeled purified porcine ZP as antigen, which is known to have cross-reactivity with human ZP. The antibodies in human sera were detected in 3 of 11 (27%) women with unexplained infertility, in 16 of 48 (33%) amenorrheic patients, in 4 of 12 (33%) fertile women, and in 3 of 10 (30%) men. Moreover, antibody titers in infertile women were no higher than those in fertile women and in men. These results seem to suggest that the antibodies in human sera that cross-react with porcine ZP may not be an important factor in causing infertility in women.

Kurachi, H.; Wakimoto, H.; Sakumoto, T.; Aono, T.; Kurachi, K.

1984-02-01

78

Embryological, clinical and ultrastructural study of human oocytes presenting indented zona pellucida.  

PubMed

Human oocyte dysmorphisms attain a large proportion of retrieved oocytes from assisted reproductive technology (ART) treatment cycles. Extracytoplasmic defects involve abnormal morphology of the zona pellucida (ZP), perivitelline space and first polar body. The aim of the present study was to describe a novel dysmorphism affecting the ZP, indented ZP. We also evaluated the clinical, embryological and ultrastructural features of these cases. We evaluated all ART treatment cycles during 7 consecutive years and found 13 treatment cycles (six patients) with all oocytes presenting an indented ZP. In addition, these oocytes presented total or partial absence of the perivitelline space, absence of resistance to ZP and oolemma penetration during microinjection, and low ooplasm viscosity during aspiration. This novel described dysmorphism was recurrent and attained all oocytes in three cases that had more than one treatment cycle. When compared with controls, data showed significant low oocyte maturity (42% versus 81.6%) and high cycle cancellation (30.8% versus 8.5%) rates, normal degeneration (3.4% versus 6.3%) and fertilization rates (69% versus 69.5%), and low pregnancy (15.4% versus 33.3%) and live-birth delivery (7.7% versus 27.7%) rates per cycle. Ultrastructure analysis revealed a zona pellucida structure with large empty electrolucent regions, an outer ZP layer with an indented surface with protuberances and a thick inner ZP that obliterated the perivitelline space. There was evidence of exocytosis of ZP material by the oocyte. In conclusion, oocytes with this novel described dysmorphism (indented ZP) are associated with low maturity, pregnancy and live-birth delivery rates. PMID:23992046

Sousa, M; Teixeira da Silva, J; Silva, J; Cunha, M; Viana, P; Oliveira, E; Sá, R; Soares, C; Oliveira, C; Barros, A

2015-02-01

79

Pitch Variability in Patients with Parkinson's Disease: Effects of Deep Brain Stimulation of Caudal Zona Incerta and Subthalamic Nucleus  

ERIC Educational Resources Information Center

Purpose: The purpose of the present study was to examine the effect of deep brain stimulation (DBS) of the subthalamic nucleus (STN) and the caudal zona incerta (cZi) pitch characteristics of connected speech in patients with Parkinson's disease (PD). Method: The authors evaluated 16 patients preoperatively and 12 months after DBS surgery. Eight…

Karlsson, Fredrik; Olofsson, Katarina; Blomstedt, Patric; Linder, Jan; van Doorn, Jan

2013-01-01

80

INDUCTION OF ZONA RADIATA PROTEINS AND VITELLOGENINS IN ESTRADIOL AND NONYLPHENOL EXPOSED MALE SHEEPSHEAD MINNOWS (CYPRINODON VARIEGATUS)  

EPA Science Inventory

Knoebl, Iris, Michael J. Hemmer and Nancy D. Denslow. 2004. Induction of Zona Radiata Proteins and Vitellogenins in Estradiol and Nonylphenol Exposed Male Sheepshead Minnows (Cyprinodon variegatus). Mar. Environ. Res. 58(2-5):547-551. (ERL,GB X1059). Several genes normall...

81

Plasticity of the zona reticularis in the adult marmoset adrenal cortex: voyages of discovery in the New World  

E-print Network

­7 years, yet the process by which dehydroepiandrosterone (DHEA) biosyn- thesis in the adrenal zona DHEA production by P450c17 (CYP17A1 as listed in HUGO Database) in the ZR results from a coincident with DHEA biosynthesis, and cloned human and rhesus P450c17 show selective increases in 17,20-lyase activity

Saltzman, Wendy

82

Descripción de la zona de alta difusión en un modelo bidimensional para hojas de corriente  

NASA Astrophysics Data System (ADS)

Los modelos bidimensionales para describir hojas de corriente de alta simetría no suministran una descripción detallada de las regiones donde la difusión es considerablemente importante. Tal es el caso de los modelos desarrollados en la década del '60 por Sweet, Parker, Petschek y Sonnerup. En esta comunicación presentamos una solución de las ecuaciones MHD en el entorno del origen, construyendo series bidimensionales para todas las magnitudes físicas involucradas. Valiéndonos de la alta simetría y de las características del problema, logramos reducir el número de coeficientes a calcular. Utilizamos un programa autoconsistente para extender el cálculo a regiones vecinas con difusión moderada o despreciable.

Montero, M. F.; Paola, C. A.; Platzeck, A. M.

83

Zona glomerulosa cells of the mouse adrenal cortex are intrinsic electrical oscillators  

PubMed Central

Aldosterone, which plays a central role in the regulation of blood pressure, is produced by zona glomerulosa (ZG) cells of the adrenal gland. When dysregulated, aldosterone is pathogenic and contributes to the development and progression of cardiovascular and renal disease. Although sustained production of aldosterone requires persistent Ca2+ entry through low-voltage activated Ca2+ channels, isolated ZG cells are considered nonexcitable, with recorded membrane voltages that are too hyperpolarized to permit Ca2+ entry. Here, we show that mouse ZG cells within adrenal slices spontaneously generate membrane potential oscillations of low periodicity. This innate electrical excitability of ZG cells provides a platform for the production of a recurrent Ca2+ signal that can be controlled by Ang II and extracellular potassium, the 2 major regulators of aldosterone production. We conclude that native ZG cells are electrical oscillators, and that this behavior provides what we believe to be a new molecular explanation for the control of Ca2+ entry in these steroidogenic cells. PMID:22546854

Hu, Changlong; Rusin, Craig G.; Tan, Zhiyong; Guagliardo, Nick A.; Barrett, Paula Q.

2012-01-01

84

Zona Pellucida Domain-Containing Protein ?-Tectorin is Crucial for Zebrafish Proper Inner Ear Development  

PubMed Central

Background The zona pellucida (ZP) domain is part of many extracellular proteins with diverse functions from structural components to receptors. The mammalian ?-tectorin is a protein of 336 amino acid residues containing a single ZP domain and a putative signal peptide at the N-terminus of the protein. It is 1 component of a gel-like structure called the tectorial membrane which is involved in transforming sound waves into neuronal signals and is important for normal auditory function. ?-Tectorin is specifically expressed in the mammalian and avian inner ear. Methodology/Principal Findings We identified and cloned the gene encoding zebrafish ?-tectorin. Through whole-mount in situ hybridization, we demonstrated that ?-tectorin messenger RNA was expressed in the otic placode and specialized sensory patch of the inner ear during zebrafish embryonic stages. Morpholino knockdown of zebrafish ?-tectorin affected the position and number of otoliths in the ears of morphants. Finally, swimming behaviors of ?-tectorin morphants were abnormal since the development of the inner ear was compromised. Conclusions/Significance Our results reveal that zebrafish ?-tectorin is specifically expressed in the zebrafish inner ear, and is important for regulating the development of the zebrafish inner ear. Lack of zebrafish ?-tectorin caused severe defects in inner ear formation of otoliths and function. PMID:21829695

Yang, Chung-Hsiang; Cheng, Chia-Hsiung; Chen, Gen-Der; Liao, Wei-Hao; Chen, Yi-Chung; Huang, Kai-Yun; Hwang, Pung-Pung; Hwang, Sheng-Ping L.; Huang, Chang-Jen

2011-01-01

85

Protein kinase C activation stimulates calcium transport in adrenal zona glomerulosa cells.  

PubMed

Adrenal zona glomerulosa (ZG) cells produce aldosterone in response to angiotensin II and extracellular potassium through different mechanisms which involve changes in cytosolic free calcium (Cai). Protein kinase C (PKC) activation is part of the angiotensin II signalling cascade but its effects on Cai are unknown. PKC activation with 1 microM phorbol 12-myristate 13-acetate (PMA) and 8 mM Ko significantly increased the rate of calcium influx (P < 0.001). Both the PKC- and the Ko-induced calcium influx occurred via a nifedipine-sensitive pathway. When both were combined, PKC activation and 8 mM Ko were not additive over either agent alone. PKC activation and 8 mM Ko also stimulated calcium efflux (P < 0.01). When combined together PKC activation and 8 mM Ko had additive effects on calcium efflux (P < 0.05). PKC activation did not increase Cai nor the exchangeable calcium pool in contrast to 8 mM Ko which significantly increased both (P < 0.001). Thus, PKC activation in ZG cells induces a pattern of calcium transport characterized by accelerated calcium recycling across the cell membrane without increasing cell calcium content. PMID:9571176

Cirillo, M; Canessa, M; Quinn, S; Conlin, P R

1998-04-17

86

Vitellogenin and zona radiata proteins as biomarkers of endocrine disruption in peregrine falcon (Falco peregrinus).  

PubMed

The aim of this study was to test a specific method for the detection of Vitellogenin (Vtg) and Zona Radiata Proteins (Zrp) in plasma from peregrine falcon (Falco peregrinus) as specific biomarkers for the evaluation of the effects of endocrine disruptors. The method was assayed with different peregrine falcon individuals (including mature and immature birds of both sexes) from a Spanish population being studied in terms of their contamination with organochlorine compounds with endocrine disrupting properties. This study shows that mouse anti bird Vtg monoclonal antibody ND3C3 (Biosense) seems to be the most specific antibody in binding plasmatic lipoproteins in peregrine falcon when compared to other anti Vtg antibodies. Rabbit anti salmon Zrp polyclonal antibodies O146 (Biosense) show cross-reactivity with Zrp in the samples studied. These preliminary results confirm the applicability of both of these diagnostic tools assayed (induction of Vtg and Zrp) in detecting exposure to Endocrine Disrupting Chemicals (EDCs) in this species. The increase of Vtg and Zrp detected in male specimens suggest a potential hazard to EDCs in the peregrine falcon which represents a species still affected by organochlorine compounds, and in particular those with estrogenic activity. PMID:17223181

Jiménez, Begoña; Mori, Gabriele; Concejero, Miguel A; Merino, Rubén; Casini, Silvia; Fossi, María Cristina

2007-04-01

87

Does empty zona pellucida indicate poor ovarian response on intra cytoplasmic sperm injection cycles?  

PubMed

The factors behind the empty zona pellucida (EZP) formation and its relationship with in vitro fertilization (IVF) outcomes were analyzed. A total of 104 patients who underwent IVF treatment and collected oocytes including EZP were enrolled in this study. EZP index (EZPI?=?the ratio of number of EZP to number of cumulus-oocyte complex (COC)) was used for the statistical analysis. Patients were grouped as Group 1 when EZPI ? 0.17 (n?=?57) and Group 2 when EZPI > 0.17 (n?=?47). Type-2 EZP, a variation or an advanced type of oocyte degeneration, is tested. Woman age, basal hormone levels, and total gonadotropin dose were significantly higher in Group 2 compared to Group 1. Total antral follicle count was significantly low in Group 2. Total number of mature oocytes, oocyte quality index, the number of fertilized oocytes, and the numbers of Grade 1 embryos were significantly low in Group 2. On the linear regression analysis, using gonadotropin releasing hormone antagonist protocol (B?=?0.086, p?=?0.030), the number of ?17?mm follicle (B?=?0.015, p?=?0.047), peak serum level of estradiol (B?=?-3.625; p?=?0.014), number of fertilized oocytes (B?=?-0.02, p?=?0.0001) and the day-2 embryo score (B?=?-0,044, p?=?0.001) significantly affected EZPI. An increment of the EZPI may be revealed decreased oocyte quality, and it is also related to the poor ovarian response. PMID:22132865

Cinar, Ozgur; Demir, Berfu; Dilbaz, Serdar; Saltek, Sevil; Aydin, Sevim; Goktolga, Umit

2012-05-01

88

Are zona pellucida laser drilling and polar body biopsy safe for in vitro matured oocytes?  

PubMed Central

Introduction Preconception diagnosis requires first polar body biopsy. When the hole in the zona pellucida is made with a laser beam, heat propagation could, like the biopsy itself, be deleterious. Our aim was to evaluate the effect of this technique on human in vitro matured oocyte and embryo development. Methods One hunded fifty five retrieved immature oocytes from 75 women, matured in vitro, were distributed in 3 groups: 50 oocytes in a control group, without laser drilling and first polar body biopsy, 52 oocytes in a group with only laser drilling, and 53 oocytes in a group with both laser drilling and first polar body biopsy. Safety was evaluated using four criteria: [1] oocyte lysis rate, [2] oocyte activation rate, [3] oocyte development after calcium ionophore treatment, [4] and embryo chromosome breakage incidence after Tarkowski preparation. Results No difference in the four criteria was observed between the 3 oocyte groups. Conclusions We did not find evidence of deleterious effect of laser drilling and first polar body biopsy on in vitro matured oocytes, according to our criteria. PMID:20495883

Hammoud, Ibrahim; Molina-Gomes, Denise; Albert, Martine; Bergere, Marianne; Bailly, Marc; Wainer, Robert; Selva, Jacqueline

2010-01-01

89

Evidence for extracellular, but not intracellular, generation of angiotensin II in the rat adrenal zona glomerulosa  

SciTech Connect

Based on the observation that high levels of renin and angiotensin II (Ang II) are found in the adrenal zona glomerulosa (ZG), it has been postulated that Ang II is formed intracellularly by the renin-converting enzyme cascade in this tissue. To test this hypothesis, the authors examined renin-angiotensin system components in subcellular fractions of the rat adrenal ZG. Renin activity and immunoreactive-Ang II (IR-Ang II) were observed in vesicular fractions but were not colocalized. In addition, angiotensinogen, angiotensin I, and converting enzyme were not observed in the renin or IR-Ang II-containing vesicular fractions. These data do not support the hypothesis that Ang II is formed intracellularly within the renin-containing vesicles of the ZG. Rather, since modulatable renin release from adrenal ZG slices was observed and renin activity was found in dense vesicular fractions (33-39% sucrose), it is likely that Ang II formation in the ZG is extracellular and initiated by the release of vesicular renin. In ZG lysomal fractions {sup 125}I-labeled Ang II was degraded to {sup 125}I-labeled des-(Phe{sup 8})Ang II. Since Ang II antibodies do not recognize des-(Phe{sup 8})Ang II, these finding explain why IR-Ang II in the ZG is due predominantly to Ang II and not to its C-terminal immunoreactive fragments.

Urata, H.; Khosla, M.C.; Bumpus, M.; Husain, A. (Research Institute of the Cleveland Clinic Foundation, OH (USA))

1988-11-01

90

In vitro fertilization and development of one of two human oocytes with fused zonae pellucidae: case report.  

PubMed

This report describes a pair of human oocytes of differing maturities but fused at the zona pellucida, believed to have originated from a binovular follicle. After insemination in vitro, one oocyte fertilized and developed into an expanded blastocyst, whereas the other, which contained a germinal vesicle, degenerated. A biopsy was aspirated from the blastocyst, which subsequently re-expanded but did not hatch. PMID:2226933

Hartshorne, G M; Blayney, M; Dyson, H; Elder, K

1990-11-01

91

Instantánea del cáncer infantil  

Cancer.gov

Información sobre la incidencia y mortalidad del cáncer en los niños, tendencias en el financiamiento del NCI para la investigación del cáncer infantil; así como ejemplos de actividades y adelantos en la investigación relevantes para esta población.

92

The zona glomerulosa of the adrenal gland in rats with portacaval shunt. An ultrastructural and morphometric study.  

PubMed Central

The zona glomerulosa of the adrenal glands was studied histologically, ultrastructurally and morphometrically in portacaval shunt (PCS)-bearing rats 4 weeks after surgery. Compared with controls, the zona glomerulosa of rats with PCS showed an increase in thickness and a reduction in the number of lipid droplets in the cells of its inner portion, adjacent to the intermediate zone. Moreover, electron microscopy and morphometry of the cells of the inner portion revealed that qualitative and quantitative changes occur, consisting in a decrease in lipid droplets, an increase in the amounts of smooth endoplasmic reticulum and mitochondria, enlargement of the Golgi apparatus, and the appearance of numerous dense bodies at the vascular cell poles. All the above findings indicate that PCS induces an enhanced activity of the fully differentiated cells of the zona glomerulosa, which may be considered as an adaptive response--mediated by an activation of the renin-angiotensin system--to the lowering of the systemic pressure taking place in this experimental condition. Images Fig. 5 Fig. 6 Fig. 7 Fig. 8 Fig. 3 Fig. 4 Fig. 1 Fig. 2 PMID:2206985

Domenici Lombardo, L.; Cortesini, C.

1990-01-01

93

Sperm mitochondrial integrity is not required for hyperactivated motility, zona binding, or acrosome reaction in the rhesus macaque.  

PubMed

Whether the main energy source for sperm motility is from oxidative phosphorylation or glycolysis has been long-debated in the field of reproductive biology. Using the rhesus monkey as a model, we examined the role of glycolysis and oxidative phosphorylation in sperm function by using alpha-chlorohydrin (ACH), a glycolysis inhibitor, and pentachlorophenol (PCP), an oxidative phosphorylation uncoupler. Sperm treated with ACH showed no change in percentage of motile sperm, although sperm motion was impaired. The ACH-treated sperm did not display either hyperactivity- or hyperactivation-associated changes in protein tyrosine phosphorylation. When treated with PCP, sperm motion parameters were affected by the highest level of PCP (200 microM); however, PCP did not cause motility impairments even after chemical activation. Sperm treated with PCP were able to display hyperactivity and tyrosine phosphorylation after chemical activation. In contrast with motility measurements, treatment with either the glycolytic inhibitor or the oxidative phosphorylation inhibitor did not affect sperm-zona binding and zona-induced acrosome reaction. The results suggest glycolysis is essential to support sperm motility, hyperactivity, and protein tyrosine phosphorylation, while energy from oxidative phosphorylation is not necessary for hyperactivated sperm motility, tyrosine phosphorylation, sperm-zona binding, and acrosome reaction in the rhesus macaque. PMID:18480469

Hung, Pei-hsuan; Miller, Marion G; Meyers, Stuart A; VandeVoort, Catherine A

2008-08-01

94

Sperm Mitochondrial Integrity Is Not Required for Hyperactivated Motility, Zona Binding, or Acrosome Reaction in the Rhesus Macaque1  

PubMed Central

Whether the main energy source for sperm motility is from oxidative phosphorylation or glycolysis has been long-debated in the field of reproductive biology. Using the rhesus monkey as a model, we examined the role of glycolysis and oxidative phosphorylation in sperm function by using alpha-chlorohydrin (ACH), a glycolysis inhibitor, and pentachlorophenol (PCP), an oxidative phosphorylation uncoupler. Sperm treated with ACH showed no change in percentage of motile sperm, although sperm motion was impaired. The ACH-treated sperm did not display either hyperactivity- or hyperactivation-associated changes in protein tyrosine phosphorylation. When treated with PCP, sperm motion parameters were affected by the highest level of PCP (200 ?M); however, PCP did not cause motility impairments even after chemical activation. Sperm treated with PCP were able to display hyperactivity and tyrosine phosphorylation after chemical activation. In contrast with motility measurements, treatment with either the glycolytic inhibitor or the oxidative phosphorylation inhibitor did not affect sperm-zona binding and zona-induced acrosome reaction. The results suggest glycolysis is essential to support sperm motility, hyperactivity, and protein tyrosine phosphorylation, while energy from oxidative phosphorylation is not necessary for hyperactivated sperm motility, tyrosine phosphorylation, sperm-zona binding, and acrosome reaction in the rhesus macaque. PMID:18480469

Hung, Pei-hsuan; Miller, Marion G.; Meyers, Stuart A.; VandeVoort, Catherine A.

2008-01-01

95

Characterization of cell surface polypeptides of unfertilized, fertilized, and protease-treated zona-free mouse eggs  

SciTech Connect

The polypeptide composition of unfertilized, fertilized, and protease-treated zona-free mouse eggs was evaluated in this study. Zona-free eggs were radioiodinated by an Iodogen-catalyzed reaction. Light microscopic autoradiography of egg sections revealed that labeling was restricted to the cell surface. Labeled eggs were solubilized, and cell surface polypeptides were identified by one-dimensional SDS polyacrylamide gel electrophoresis and autoradiography. The unfertilized egg demonstrated 8-10 peptides that incorporated {sup 125}I, with major bands observed at approximately 145-150, 94, and 23 kilodaltons (kD). Zona-free eggs fertilized in vitro and then radiolabeled demonstrated several new bands in comparison to unfertilized eggs, with a major band appearing at approximately 36 kD. Treatment of radiolabeled unfertilized eggs with either trypsin or chymotrypsin (1 mg/ml for 5-20 min) caused enzyme-specific modifications in labeled polypeptides. Trypsin (T) treatment resulted in time-dependant modification of the three major peptides at 145-150, 94, and 23 kD. Chymotrypsin (CT) treatment, in contrast, was associated with loss or modification of the 94 kD band, with no apparent effect on either the 145-150 or 23 kD band. Taken together with previous data indicating that T or CT egg treatment interferes with sperm-egg attachment and fusion, these results suggest a possible role for the 94 kD protein in sperm-egg interaction.

Boldt, J.; Gunter, L.E.; Howe, A.M. (Medical College of Georgia, Augusta (USA))

1989-05-01

96

[Role of sperm passage through cervical mucus: fertilizing capacity tested by in vitro fertilization with zona-free hamster eggs].  

PubMed

The effect of sperm passage through cervical mucus (CM) on the fertilizing capacity of human spermatozoa was examined in the in vitro fertilization system of zona-free hamster eggs. Each drop of ejaculated semen and BWW culture medium was connected by a small capillary tube filled with preovulatory CM, egg white or BWW medium under liquid paraffin oil in a plastic petri dish. After 2 hours, zona-free hamster eggs were added to the drop of BWW culture medium containing spermatozoa which had passed through the capillary tube and the mixture was incubated for various lengths of time at 37 degrees C under 5% CO2 in air. Human spermatozoa, which were washed and preincubated for 2 hours in BWW medium, were capable of fertilizing zona-free hamster eggs but needed a longer incubation time than spermatozoa which had passed through CM. Fertilization rates of spermatozoa which had passed through CM and egg white were very similar, but no fertilization occurred in the drop containing spermatozoa which had passed through BWW medium, presumably because of the contamination with seminal plasma. These results indicate that the most important role of CM may be to separate motile spermatozoa from seminal plasma components hostile to fertilization. PMID:2723485

Ikuma, K; Suno, S; Hasegawa, A; Koyama, K; Isojima, S

1989-02-01

97

Atlas del Genoma del Cáncer: Antecedentes  

Cancer.gov

El Atlas del Genoma del Cáncer es una iniciativa de los Institutos Nacionales de la Salud (NIH) para crear mapas multidimensionales completos de los cambios genómicos clave en los tipos y subtipos principales de cáncer.

98

Uncontacted Waorani in the Yasuní Biosphere Reserve: Geographical Validation of the Zona Intangible Tagaeri Taromenane (ZITT)  

PubMed Central

The Tagaeri Taromenane People are two indigenous groups belonging to the Waorani first nation living in voluntary isolation within the Napo region of the western Amazon rainforest. To protect their territory the Ecuadorean State has declared and geographically defined, by Decrees, the Zona Intangible Tagaeri Taromenane (ZITT). This zone is located within the UNESCO Yasuní Biosphere Reserve (1989), one of the most biodiverse areas in the world. Due to several hydrocarbon reserve exploitation projects running in the area and the advancing of a large-scale deforestation front, the survival of these groups is presently at risk. The general aim was to validate the ZITT boundary using the geographical references included in the Decree 2187 (2007) by analyzing the geomorphological characteristics of the area. Remote sensing data such as Digital Elevation Models (DEM), Landsat imagery, topographic cartography of IGM-Ecuador, and fieldwork geographical data have been integrated and processed by Geographical Information System (GIS). The ZITT presents two levels of geographic inconsistencies. The first dimension is about the serious cartographical weaknesses in the perimeter delimitation related to the impossibility of linking two rivers belonging to different basins while the second deals with the perimeter line not respecting the hydrographic network. The GIS analysis results clearly show that ZITT boundary is cartographically nonsense due to the impossibility of mapping out the perimeter. Furthermore, GIS analysis of anthropological data shows presence of Tagaeri Taromenane clans outside the ZITT perimeter, within oil production areas and in nearby farmer settlements, reflecting the limits of protection policies for non-contacted indigenous territory. The delimitation of the ZITT followed a traditional pattern of geometric boundary not taking into account the nomadic characteristic of Tagaeri Taromenane: it is necessary to adopt geographical approaches to recognize the indigenous right to their liveable territories in the complex territorialities enacted by different stakeholders. PMID:23840436

Pappalardo, Salvatore Eugenio; De Marchi, Massimo; Ferrarese, Francesco

2013-01-01

99

Uncontacted Waorani in the Yasuní Biosphere Reserve: Geographical Validation of the Zona Intangible Tagaeri Taromenane (ZITT).  

PubMed

The Tagaeri Taromenane People are two indigenous groups belonging to the Waorani first nation living in voluntary isolation within the Napo region of the western Amazon rainforest. To protect their territory the Ecuadorean State has declared and geographically defined, by Decrees, the Zona Intangible Tagaeri Taromenane (ZITT). This zone is located within the UNESCO Yasuní Biosphere Reserve (1989), one of the most biodiverse areas in the world. Due to several hydrocarbon reserve exploitation projects running in the area and the advancing of a large-scale deforestation front, the survival of these groups is presently at risk. The general aim was to validate the ZITT boundary using the geographical references included in the Decree 2187 (2007) by analyzing the geomorphological characteristics of the area. Remote sensing data such as Digital Elevation Models (DEM), Landsat imagery, topographic cartography of IGM-Ecuador, and fieldwork geographical data have been integrated and processed by Geographical Information System (GIS). The ZITT presents two levels of geographic inconsistencies. The first dimension is about the serious cartographical weaknesses in the perimeter delimitation related to the impossibility of linking two rivers belonging to different basins while the second deals with the perimeter line not respecting the hydrographic network. The GIS analysis results clearly show that ZITT boundary is cartographically nonsense due to the impossibility of mapping out the perimeter. Furthermore, GIS analysis of anthropological data shows presence of Tagaeri Taromenane clans outside the ZITT perimeter, within oil production areas and in nearby farmer settlements, reflecting the limits of protection policies for non-contacted indigenous territory. The delimitation of the ZITT followed a traditional pattern of geometric boundary not taking into account the nomadic characteristic of Tagaeri Taromenane: it is necessary to adopt geographical approaches to recognize the indigenous right to their liveable territories in the complex territorialities enacted by different stakeholders. PMID:23840436

Pappalardo, Salvatore Eugenio; De Marchi, Massimo; Ferrarese, Francesco

2013-01-01

100

Analysis of recombinant mouse zona pellucida protein 2 (ZP2) constructs for immunocontraception.  

PubMed

In this study we have examined the potential of recombinant mouse zona pellucida glycoprotein 2 (ZP2) as a target for immunocontraception. Immunogenicity studies and fertility trials were performed in outbred Swiss-Webster mice using four ZP2 constructs: Val(35)-Gly(200) (ZP2(V35-G200)), Val(35)-Leu(331) (ZP2(V35-L331)), Pro(325)-Ala(637) (ZP2(P325-A637)), and Val(35)-Ala(637) (ZP2(V35-A637)). A significant antibody response occurred to three of the four immunogens, however antibodies capable of recognizing native ZP occurred only after immunization with ZP2(V35-A637) and ZP2(P325-A637). Only immunization with ZP2(V35-A637) correlated with a reduction in fertility. Examination of the physiological basis for infertility revealed that: (1) passive transfer of ZP2 antiserum induced infertility in non-immune mice; (2) ovaries of infertile mice appeared histologically normal; (3) infertile mice produced normal numbers of eggs and (4) ZP of ovulated eggs from infertile mice demonstrated a significant reduction in the number of sperm bound compared to eggs from adjuvant controls. Infertility can be caused entirely by ZP2 antibodies without the incidence of significant ovarian pathology. This study also demonstrated that immunization with the bioactive (sperm binding) region of ZP2, recombinant ZP2(V35-G200), did not result in a significant immune response that recognized native ZP or inhibited fertility. Consequently we designed a ZP2-sperm antigen construct, replacing the C-terminal region of ZP2 with Sp17. This construct proved to be immunogenic and reduce fertility while directing the immune response to the Val(35)-Gly(200) region of ZP2. PMID:11858857

Lea, Isabel A; Widgren, Esther E; O'Rand, Michael G

2002-02-22

101

Rat subthalamic nucleus and zona incerta share extensively overlapped representations of cortical functional territories.  

PubMed

The subthalamic nucleus (STN) and the zona incerta (ZI) are two major structures of the subthalamus. The STN has strong connections between the basal ganglia and related nuclei. The ZI has strong connections between brainstem reticular nuclei, sensory nuclei, and nonspecific thalamic nuclei. Both the STN and ZI receive heavy projections from a subgroup of layer V neurons in the cerebral cortex. The major goal of this study was to investigate the following two questions about the cortico-subthalamic projections using the lentivirus anterograde tracing method in the rat: 1) whether cortical projections to the STN and ZI have independent functional organizations or a global organization encompassing the entire subthalamus as a whole; and 2) how the cortical functional zones are represented in the subthalamus. This study revealed that the subthalamus receives heavy projections from the motor and sensory cortices, that the cortico-subthalamic projections have a large-scale functional organization that encompasses both the STN and two subdivisions of the ZI, and that the group of cortical axons that originate from a particular area of the cortex sequentially innervate and form separate terminal fields in the STN and ZI. The terminal zones formed by different cortical functional areas have highly overlapped and fuzzy borders, as do the somatotopic representations of the sensorimotor cortex in the subthalamus. The present study suggests that the layer V neurons in the wide areas of the sensorimotor cortex simultaneously control STN and ZI neurons. Together with other known afferent and efferent connections, possible new functionality of the STN and ZI is discussed. PMID:25048050

Kita, Takako; Osten, Pavel; Kita, Hitoshi

2014-12-15

102

Foaling rates in feral horses treated with the immunocontraceptive porcine zona pellucida  

USGS Publications Warehouse

Locally abundant feral horses (Equus caballus) can rapidly deplete available resources. Fertility control agents present promising nonlethal tools for reducing their population growth rates. We tested the effect of 2 forms of the immunocontraceptive porcine zona pellucida (PZP) on foaling rates in 3 populations of feral horses in the western United States. A liquid form requiring annual boosters was administered at Little Book Cliffs Wild Horse Range, Mesa County (CO), and Pryor Mountain Wild Horse Range, Bighorn County (WY) and Carbon County (MT), and a time-release pellet form designed to produce 2 yr of infertility was administered at McCullough Peaks Herd Management Area, Park County (WY). Average foaling rates (foals born/mare-yr) from direct observation of untreated and treated female horses (mares), 2004-2008, were 60.1% (n = 153 mare-yr) versus 6.6% (n = 91 mare-yr) at Little Book Cliffs, and 62.8% (n = 129 mare-yr) versus 17.7% (n = 79 mare-yr) at Pryor Mountain, respectively. At McCullough Peaks, mean annual foaling rates from 2006 to 2008 were 75.0% (n = 48 mare-yr) for untreated mares and 31.7% (n = 101 mare-yr) for treated mares. Controlling for age of mares and pretreatment differences in fertility, PZP reduced foaling rates in all 3 herds. The pellets used at McCullough Peaks (produced by cold evaporation) were less effective than pellets used in a previous trial and produced by heat extrusion. Immunocontraception with PZP may be a useful tool in reducing fertility rates in some western United States feral horse herds, but population growth reduction will depend on timely access to mares for inoculation and the proportion of mares that can be successfully treated. ?? 2011 The Wildlife Society.

Ransom, J.I.; Roelle, J.E.; Cade, B.S.; Coates-Markle, L.; Kane, A.J.

2011-01-01

103

Preliminary evaluation of porcine zona pellucida (PZP) immunocontraception for behavioral effects in feral horses (Equus caballus).  

PubMed

Successful management of captive populations of wild animals requires effective control of reproduction. Contraception is one tool for controlling reproduction of animals in zoos; however, the options available to the animal manager are limited. Contraceptives vary in efficacy, reversibility, and side effects, and thus may not be suitable for widespread use. One consideration when selecting a contraceptive is its potential for side effects on behavior, especially given the fact that reproduction plays such a prominent role in the biology of any species. To date, there have been few evaluations of contraceptives for behavioral effects, and those that have been conducted have focused on hormone-based contraceptives. This study sought to evaluate a novel method of population control, immunocontraception, for behavioral effects in a population of feral horses. Porcine zona pellucida (PZP) immunocontraception prevents fertilization of ova and does not alter normal hormone secretion patterns. It therefore should leave the animal behaviorally intact in terms of reproductive behavior. The study examined the behavior of 43 sexually mature mares on Assateague Island during the 1997 breeding season and, with help from Earthwatch volunteers, collected observations over a 3-month period. The study found no significant differences between treated and untreated mares in general activity budget, aggression given or received, and spatial relationships relative to the stallion. These preliminary findings indicate that PZP contraception seems to have no acute behavioral effects on the behavior of individuals. The study findings also suggest that PZP could be a desirable and effective management tool for captive species in which social behavior plays an integral role in group dynamics. Analyses of group level effects and population level effects are continuing. PMID:16363936

Powell, D M

1999-01-01

104

Antinociceptive effect of stimulating the zona incerta with glutamate in rats.  

PubMed

The zona incerta (ZI) is a subthalamic nucleus connected to several structures, some of them known to be involved with antinociception. The ZI itself may be involved with both antinociception and nociception. The antinociceptive effects of stimulating the ZI with glutamate using the rat tail-flick test and a rat model of incision pain were examined. The effects of intraperitoneal antagonists of acetylcholine, noradrenaline, serotonin, dopamine, or opioids on glutamate-induced antinociception from the ZI in the tail-flick test were also evaluated. The injection of glutamate (7 ?g/0.25 ?l) into the ZI increased tail-flick latency and inhibited post-incision pain, but did not change the animal performance in a Rota-rod test. The injection of glutamate into sites near the ZI was non effective. The glutamate-induced antinociception from the ZI did not occur in animals with bilateral lesion of the dorsolateral funiculus, or in rats treated intraperitoneally with naloxone (1 and 2 m/kg), methysergide (1 and 2 m/kg) or phenoxybenzamine (2 m/kg), but remained unchanged in rats treated with atropine, mecamylamine, or haloperidol (all given at doses of 1 and 2 m/kg). We conclude that the antinociceptive effect evoked from the ZI is not due to a reduced motor performance, is likely to result from the activation of a pain-inhibitory mechanism that descends to the spinal cord via the dorsolateral funiculus, and involves at least opioid, serotonergic and ?-adrenergic mechanisms. This profile resembles the reported effects of these antagonists on the antinociception caused by stimulating the periaqueductal gray or the pedunculopontine tegmental nucleus. PMID:22327011

Petronilho, Ariane; Reis, Gláucia M; Dias, Quintino M; Fais, Rafael S; Prado, Wiliam A

2012-05-01

105

Políticas del sitio web  

Cancer.gov

En el sitio web del NCI se proporcionan enlaces a otros sitios web con fines informativos y para conveniencia del público. Si el usuario selecciona un sitio web externo, saldrá del sitio web del NCI y estará sujeto a las políticas de privacidad y seguridad de dicho sitio.

106

The origin and assembly of a zona pellucida binding protein, IAM38, during spermiogenesis.  

PubMed

IAM38 is the most prominent protein of the inner acrosomal membrane extracellular coat (IAMC) of spermatozoa. It is retained by the inner acrosomal membrane after the acrosome reaction and is implicated in secondary sperm-zona binding (Yu et al., Dev Biol2006;290:32-43). Its gene knockout, Zpbp1(-/-), prevents acrosome compaction and leads to acrosome fragmentation and sterility in male mice (Lin et al., Mol Cell Biol2007;27:6794-6805). Because of this protein's important role in acrosomal formation and fertilization, the authors were interested in tracing its origin and expression during spermiogenesis. The authors reasoned that a detailed immunocytochemical investigation, utilizing anti-IAM38 antibodies as probes at the ultrastructural level, could reveal the processes involved in assembly of the IAMC and the compaction of the acrosome. High level of the IAM38 transcript was already detectable at postnatal day 20, corresponding to the time in mouse testis development when round spermatids first appear and acrosomal formation is initiated. IAM38 protein was first seen during this time (Golgi phase of spermiogenesis) within the dense core of the proacrosomal granules (PG) of round spermatids. After PG fusion to form the acrosomic vesicle (AV) the immunoreactivity was concentrated in the centrally located acrosomic granule (AG) of the AV, until acrosomal-nuclear docking occurred. Subsequently, in the cap phase, IAM38 migrated from the AG to the extracellular side of the acrosomal membrane, eventually disappearing altogether from the AG. During the elongation phase IAM38 labeling disappeared from the outer acrosomal membrane (OAM) in the apical and principal segments of the acrosome but remained lining the OAM in the equatorial segment (ES) as well as the entire IAM of the acrosome. Compaction of the ES in the maturation phase of spermiogenesis coincided with the IAM38-labeled extracellular coat of the inner and outer acrosomal membranes coming together in close proximity of each other to form a "zipper-like" structure found in the ES of mature spermatozoa. In summary, the results set a precedent, showing for the first time that glycoproteins, which originate in the acrosomic granule can be transferred to the acrosomal membrane during acrosome formation. Furthermore, the localization of IAM38 on the extracellular side of both the inner and outer acrosomal membrane during the cap phase of acrosomal development supports the role of this prominent protein in acrosomal compaction. PMID:19204925

Yu, Yang; Vanhorne, Judy; Oko, Richard

2009-08-01

107

Two subunits of the 55 K porcine zona pellucida glycoprotein family are immunologically distinct  

SciTech Connect

The 55K glycoprotein family (ZP3) of the porcine zona pellucida is comprised of two subunits of 46 K and 45 K which can be resolved by endo-..beta..-galactosidase digestion of ZP3 followed by reversed phase HPLC on Vydac C4 resin. Gel electrophoresis revealed that the 46 K component (EBDG..cap alpha..) is approx. 95% pure and the 45 K component (EBGD..beta..) is 100% pure. In the present study, these two subunits were evaluated immunologically by RIA. Under similar reaction protocols (chloramine-T iodination procedure) comparable specific activities were obtained for EBGD..cap alpha.. (33.06 +/- 7.5 ..mu..ci/..mu..gm), EBGD..beta.. (30.45 +/- 1.6) and ZP3 (26.3 +/- 1.3). Antibody (Ab) titration studies revealed that EBGD..cap alpha.. and ..beta.. are potent immunogens and /sup 125/I-EBGD..cap alpha.. showed minimal cross reactivity to EBGD..beta..-Ab (8% bound at 1:500 dilution), whereas, /sup 125/I-EBGD..beta.. showed a greater degree of cross reactivity to EBGD..cap alpha..-Ab (23% bound at 1:500 dilution). Maximum binding for the two labeled antigens against homologous Abs (1:500) was > 60%. Dose response studies revealed that in the /sup 125/I-EBGD..cap alpha.. vs EBGD..cap alpha.. -Ab system, the 50% intercept was 3.25 +/- 0.32 ng for EBGD..cap alpha.. and 472.43 +/- 30.26 ng for EBGD..beta.. (p < 0.01), whereas, in the /sup 125/I-EBGD..beta.. vs EBGD..beta..-Ab system the 50% intercept was 3.51 +/- 0.58 for EBGD..beta.. and 166.77 +/- 49.20 for EBGD..cap alpha.. (p < 0.01). No significant differences were observed in the slopes of the dose response curves. It is concluded that the two subunits of ZP3 possess distinct immunologic characteristics as evaluated by RIA.

Subramanian, M.G.; Yurewicz, E.C.; Sacco, A.G.

1986-03-01

108

Zona pellucida binding ability and responsiveness to ionophore challenge of cryopreserved dog spermatozoa after different periods of capacitation in vitro.  

PubMed

The present study was aimed to evaluate the functional status of cryopreserved dog spermatozoa after different periods (2, 8 and 24 h) of capacitation in vitro. Sperm motility, viability and binding capacity to the zona pellucida of canine oocytes derived from frozen-thawed ovaries were evaluated at each time point. Sperm viability was assessed by flow cytometry using the Ca(2+)-sensitive indicator Fluo 3 AM and PI, to simultaneously detect the proportion of live spermatozoa and the existence of live sperm subpopulations with different intracellular Ca(2+) content. In addition, the acrosome reaction frequency in ionophore-treated aliquots of spermatozoa incubated in capacitating (CCM) versus non-capacitating (NCM) medium, were evaluated by using eosin-nigrosin staining at the same time intervals. The number of spermatozoa bound to the zona pellucida decreased in about 50% (from 18.61 +/- 14.40 to 7.7 +/- 6.97) when sperm incubation was prolonged from 2 to 8h, however, sperm motility, viability and the subpopulation of live spermatozoa with higher intracellular Ca(2+) concentration decreased in lower extent (10-15%). In CCM-incubated samples, the rate of acrosomal exocytosis in response to ionophore challenge was high (>80%), independently of the evaluation period. NCM-incubated sperm were not affected by ionophore treatment, however, their intracellular Ca(2+) concentration was no different than that observed in CCM-incubated spermatozoa. It was concluded that, after being capacitated, motile and viable spermatozoa seem to lose their ability to bind to the zona pellucida, but this loss is not accompanied by a reduced response to ionophore challenge and it may not be related with changes in the intracellular Ca(2+) concentration of spermatozoa. PMID:15302398

Peña, A I; Barrio, M; Becerra, J J; Quintela, L A; Herradón, P G

2004-08-01

109

DACH1, a Zona Glomerulosa Selective Gene in the Human Adrenal, Activates Transforming Growth Factor-? Signaling and Suppresses Aldosterone Secretion  

PubMed Central

Common somatic mutations in CACNAID and ATP1A1 may define a subgroup of smaller, zona glomerulosa (ZG)–like aldosterone-producing adenomas. We have therefore sought signature ZG genes, which may provide insight into the frequency and pathogenesis of ZG-like aldosterone-producing adenomas. Twenty-one pairs of zona fasciculata and ZG and 14 paired aldosterone-producing adenomas from 14 patients with Conn’s syndrome and 7 patients with pheochromocytoma were assayed by the Affymetrix Human Genome U133 Plus 2.0 Array. Validation by quantitative real-time polymerase chain reaction was performed on genes >10-fold upregulated in ZG (compared with zona fasciculata) and >10-fold upregulated in aldosterone-producing adenomas (compared with ZG). DACH1, a gene associated with tumor progression, was further analyzed. The role of DACH1 on steroidogenesis, transforming growth factor-?, and Wnt signaling activity was assessed in the human adrenocortical cell line, H295R. Immunohistochemistry confirmed selective expression of DACH1 in human ZG. Silencing of DACH1 in H295R cells increased CYP11B2 mRNA levels and aldosterone production, whereas overexpression of DACH1 decreased aldosterone production. Overexpression of DACH1 in H295R cells activated the transforming growth factor-? and canonical Wnt signaling pathways but inhibited the noncanonical Wnt signaling pathway. Stimulation of primary human adrenal cells with angiotensin II decreased DACH1 mRNA expression. Interestingly, there was little overlap between our top ZG genes and those in rodent ZG. In conclusion, (1) the transcriptome profile of human ZG differs from rodent ZG, (2) DACH1 inhibits aldosterone secretion in human adrenals, and (3) transforming growth factor-? signaling pathway is activated in DACH1 overexpressed cells and may mediate inhibition of aldosterone secretion in human adrenals. PMID:25776071

Zhou, Junhua; Shaikh, Lalarukh Haris; Neogi, Sudeshna G.; McFarlane, Ian; Zhao, Wanfeng; Figg, Nichola; Brighton, Cheryl A.; Maniero, Carmela; Teo, Ada E.D.; Azizan, Elena A. B.

2015-01-01

110

DACH1, a Zona Glomerulosa Selective Gene in the Human Adrenal, Activates Transforming Growth Factor-? Signaling and Suppresses Aldosterone Secretion.  

PubMed

Common somatic mutations in CACNAID and ATP1A1 may define a subgroup of smaller, zona glomerulosa (ZG)-like aldosterone-producing adenomas. We have therefore sought signature ZG genes, which may provide insight into the frequency and pathogenesis of ZG-like aldosterone-producing adenomas. Twenty-one pairs of zona fasciculata and ZG and 14 paired aldosterone-producing adenomas from 14 patients with Conn's syndrome and 7 patients with pheochromocytoma were assayed by the Affymetrix Human Genome U133 Plus 2.0 Array. Validation by quantitative real-time polymerase chain reaction was performed on genes >10-fold upregulated in ZG (compared with zona fasciculata) and >10-fold upregulated in aldosterone-producing adenomas (compared with ZG). DACH1, a gene associated with tumor progression, was further analyzed. The role of DACH1 on steroidogenesis, transforming growth factor-?, and Wnt signaling activity was assessed in the human adrenocortical cell line, H295R. Immunohistochemistry confirmed selective expression of DACH1 in human ZG. Silencing of DACH1 in H295R cells increased CYP11B2 mRNA levels and aldosterone production, whereas overexpression of DACH1 decreased aldosterone production. Overexpression of DACH1 in H295R cells activated the transforming growth factor-? and canonical Wnt signaling pathways but inhibited the noncanonical Wnt signaling pathway. Stimulation of primary human adrenal cells with angiotensin II decreased DACH1 mRNA expression. Interestingly, there was little overlap between our top ZG genes and those in rodent ZG. In conclusion, (1) the transcriptome profile of human ZG differs from rodent ZG, (2) DACH1 inhibits aldosterone secretion in human adrenals, and (3) transforming growth factor-? signaling pathway is activated in DACH1 overexpressed cells and may mediate inhibition of aldosterone secretion in human adrenals. PMID:25776071

Zhou, Junhua; Shaikh, Lalarukh Haris; Neogi, Sudeshna G; McFarlane, Ian; Zhao, Wanfeng; Figg, Nichola; Brighton, Cheryl A; Maniero, Carmela; Teo, Ada E D; Azizan, Elena A B; Brown, Morris J

2015-05-01

111

Assessment of Mouse Germinal Vesicle Stage Oocyte Quality by Evaluating the Cumulus Layer, Zona Pellucida, and Perivitelline Space  

PubMed Central

To improve the outcome of assisted reproductive technology (ART) for patients with ovulation problems, it is necessary to retrieve and select germinal vesicle (GV) stage oocytes with high developmental potential. Oocytes with high developmental potential are characterized by their ability to undergo proper maturation, fertilization, and embryo development. In this study, we analyzed morphological traits of GV stage mouse oocytes, including cumulus cell layer thickness, zona pellucida thickness, and perivitelline space width. Then, we assessed the corresponding developmental potential of each of these oocytes and found that it varies across the range measured for each morphological trait. Furthermore, by manipulating these morphological traits in vitro, we were able to determine the influence of morphological variation on oocyte developmental potential. Manually altering the thickness of the cumulus layer showed strong effects on the fertilization and embryo development potentials of oocytes, whereas manipulation of zona pellucida thickness effected the oocyte maturation potential. Our results provide a systematic detailed method for selecting GV stage oocytes based on a morphological assessment approach that would benefit for several downstream ART applications. PMID:25144310

Liu, Ying-Lei; Chen, Ying; Zhou, Cheng-Jie; Wu, Sha-Na; Shen, Jiang-Peng; Liang, Cheng-Guang

2014-01-01

112

Cupulin Is a Zona Pellucida-Like Domain Protein and Major Component of the Cupula from the Inner Ear  

PubMed Central

The extracellular membranes of the inner ear are essential constituents to maintain sensory functions, the cupula for sensing torsional movements of the head, the otoconial membrane for sensing linear movements and accelerations like gravity, and the tectorial membrane in the cochlea for hearing. So far a number of structural proteins have been described, but for the gelatinous cupula precise data are missing. Here, we describe for the first time a major proteinogenic component of the cupula structure with an apparent molecular mass of 45 kDa from salmon. Analyses of respective peptides revealed highly conserved amino-acid sequences with identity to zona pellucida-like domain proteins. Immunohistochemistry studies localized the protein in the ampulla of the inner ear from salmon and according to its anatomical appearance we identified this glycoprotein as Cupulin. Future research on structure and function of zona pellucida-like domain proteins will enhance our knowledge of inner ear diseases, like sudden loss of vestibular function and other disturbances. PMID:25369234

Dernedde, Jens; Weise, Christoph; Müller, Eva-Christina; Hagiwara, Akira; Bachmann, Sebastian; Suzuki, Mamoru; Reutter, Werner; Tauber, Rudolf; Scherer, Hans

2014-01-01

113

Identification of human sperm proteins that interact with human zona pellucida3 (ZP3) using yeast two-hybrid system  

PubMed Central

Sperm proteins that interact with zona pellucida 3 (ZP3) have not been clearly identified in humans. In the present study, the yeast two-hybrid (Y2H) system was used to identify human sperm proteins that interact with human ZP3. Human ZP3 cDNA was cloned into pAS2-1 yeast vector and used as bait to find reactive proteins in the human testis cDNA library. Six specific clones were obtained that were further confirmed for interaction using the mammalian two-hybrid system. These six clones showed homologies with several proteins in the GenBank database. Of these, the strongest ZP3 interacting protein, that shows 97% homology with ubiquitin associated protein-2 like (UBAP2L), was tested in the hemizona assay. UBAP2L antibodies significantly (p < 0.001) inhibited human sperm-zona binding in this assay. We conclude that the Y2H system is a useful strategy for identifying novel genes encoding proteins that interact with ZP proteins. To our knowledge, this is the first study using the Y2H system to identify sperm proteins that interact with human oocyte ZP3. Novel proteins identified using this system may find applications in elucidating the fertilization cascade, development of a new generation of non-steroidal contraceptives, and specific diagnosis and treatment of human infertility. PMID:19945174

Naz, Rajesh K.; Dhandapani, Latha

2010-01-01

114

Omnipresencia del paralelismo Objetivos del proyecto  

E-print Network

-Secundaria Incorporaci´on de contenidos de programaci´on paralela en la rama de tecnolog´ias inform´aticas Facultad;Omnipresencia del paralelismo Objetivos del proyecto Material a desarrollar Programaci´on paralela Para explotar componentes computacionales, para lo que se utiliza la programaci´on paralela. Tipos b´asicos: Dentro de un

Giménez, Domingo

115

Instantánea del cáncer colorrectal  

Cancer.gov

Información sobre las tendencias de incidencia, mortalidad y financiamiento del NCI sobre el cáncer colorrectal; así como ejemplos de actividades del NCI y adelantos en la investigación de este tipo de cáncer.

116

Los plaguicidas y la contaminacion del medio ambiente Venezolano  

USGS Publications Warehouse

RESUMEN DE RECOMENDACIONES Recomendaciones para el Programa de Investigacion: 1. Establecer un sistema de muestreo biologico para detectar los niveles tendencias de los productos quimicos toxicos en un peque?o numero de si tios representativos. 2. Mantener continua vigilancia de la contaminacion ambiental, mediante la seleccion acertadamente dirigida de las zonas afectadas y de las fuentes de contaminacion. 3. Realizar estudios acerca de las poblaciones de animales silvestres, y del exito de los procesos reproductivos de las especies o grupos clayes de animales que se consideran mas gravemente afectados. 4. Preparar recomendaciones para una accion gubernamental de proteccion al hombre, a la fauna silvestre y al medio ambiente. Recomendaciones para la Accion Administrativa: 1. Establecer limites a la tolerancia de los residuos de plaguicidas en los alimentos. Constituye una medida clave para disminuir la contaminacion ambiental. 2. Establecer normas de calidad del agua para las corrientes, represas, la gos y otros cuerpos. Es la segunda medida clave para reducir la contaminacion del ambiente 3. Exigir un tratamiento adecuado de los efluentes industriales, especialmente antes de que se construyan las nuevas plantas. 4. Exigir a los agricultores que en el uso de plaguicidas sigan los consejos tecnicos autorizados y negar a los vendedores el derecho a recomendar productos por su cuenta. 5. Tomar medidas para recoger y eliminar los recipientes y sobrantes de los plaguicidas.

Stickel, L.F.; Stickel, W.H.

1972-01-01

117

Redes sociales del NCI  

Cancer.gov

Instituto Nacional del CáncerLa página de Facebook cuenta con información de cáncer dirigida al público de habla hispana. Visite nuestra página para leer noticias sobre la investigación del cáncer, conocer los recursos del NCI y publicar sus comentarios y preguntas relacionadas con el cáncer.

118

INTRODUCCION DESCRIPCION DEL PROGRAMA  

E-print Network

INTRODUCCION DESCRIPCION DEL PROGRAMA ADMISION, BECAS E INSTRUMENTOS DE APOYO Programa de Doctorado´atica, U. de Concepci´on, Chile #12;INTRODUCCION DESCRIPCION DEL PROGRAMA ADMISION, BECAS E INSTRUMENTOS DE´on, Chile #12;INTRODUCCION DESCRIPCION DEL PROGRAMA ADMISION, BECAS E INSTRUMENTOS DE APOYO ENTORNO LA

Bürger, Raimund

119

Efficiency of asynchronously in vitro-matured oocytes as recipients for nuclear transfer and of blind enucleation in zona-free bovine cloning.  

PubMed

We studied the dynamics of in vitro maturation of bovine oocytes, the efficiency of asynchronously matured oocytes as recipients for the generation of embryos produced by nuclear transfer, and the potential for using blind enucleation of zona-free bovine oocytes in bovine cloning. At 15 h after the initiation of maturation (hpm), oocytes were freed from both cumulus cells and the zona pellucida, and the dynamics of oocyte maturation were monitored every 30 min through the criterion of extrusion of the first polar body (PB1). More than 41% of bovine oocytes had extruded PB1 by 16.5 hpm, and were designated as representing a group of rapidly maturing oocytes. A second group, comprising about 25% of all oocytes, had extruded PB1 by 18.5-20.0 hpm. Examination of Hoechst 33342-stained samples demonstrated that PB1 on the surfaces of zona-free bovine oocytes were always located near the maternal chromosomes. Zona-free oocytes were enucleated by removing PB1 and about 3% of the adjacent oocyte cytoplasm without chromatin staining. Successful enucleation of zona-free bovine oocytes was achieved in 96.9% of cases. The rate of development to the blastocyst stage was significantly greater in embryos reconstructed from rapidly maturing oocytes (47.8%) than with oocytes maturing at 18.0-20.0 hpm (33.3%). Overall, two large groups of bovine oocytes could be distinguished during in vitro maturation by the time required to reach the second stage of metaphase. Bovine embryos reconstructed from rapidly maturing enucleated oocytes had a significantly greater rate of development to the blastocyst stage than did embryos derived from later-maturing oocytes. We conclude that blind enucleation is a simple and efficient method for preparing cytoplasts in zona-free bovine cloning. PMID:19508117

Malenko, Galina P; Stepanov, Oleg I; Komissarov, Andrey V; Antipova, Tatyana A; Pinyugina, Marina V; Prokofiev, Michael I

2009-06-01

120

Do endocrine disrupting chemicals threaten Mediterranean swordfish? Preliminary results of vitellogenin and Zona radiata proteins in Xiphias gladius.  

PubMed

Endocrine Disrupting Chemicals (EDCs) have the potential to alter hormone pathways that regulate reproductive processes in wildlife and fishes. In this research the hypothesis that Mediterranean top predator species (such as large pelagic fish) are potentially at risk due to EDCs is investigated. These marine organisms tend to accumulate high concentrations of EDCs such as polyhalogenated aromatic hydrocarbons (PHAHs). The potential effects of EDCs on a fish species of commercial interest, the top predator Xiphias gladius (swordfish), were investigated using vitellogenin (Vtg) and Zona radiata proteins (Zrp) as diagnostic and prognostic biomarkers. Dramatic induction of typically female proteins (Vtg and Zrp) was detected by ELISA and Western Blot in adult males of the species. These results are the first warning of the potential risk for reproductive function of Mediterranean top predators, and suggest the need for continuous monitoring of this fragile marine environment. PMID:11763150

Fossi, M C; Casini, S; Ancora, S; Moscatelli, A; Ausili, A; Notarbartolo-di-Sciara, G

2001-12-01

121

Perceived articulatory precision in patients with Parkinson's disease after deep brain stimulation of subthalamic nucleus and caudal zona incerta.  

PubMed

The effect of deep brain stimulation (DBS) of the subthalamic nucleus (STN) and caudal zona incerta (cZi) on speech articulation in patients with Parkinson's disease (PD) was investigated. Read speech samples were collected from nine patients with STN-DBS and 10 with cZi-DBS. The recordings were made pre-operatively and 12 months post-operatively with stimulator on and off (on medication). Blinded, randomised, repeated perceptual assessments were performed on words and isolated fricatives extracted from the recordings to assess (1) overall articulatory quality ratings, (2) frequency of occurrence of misarticulation patterns and (3) fricative production. Statistically significant worsening of articulatory measures on- compared with off-stimulation occurred in the cZi-DBS group, with deteriorated articulatory precision ratings, increased presence of misarticulations (predominately altered realisations of plosives and fricatives) and a reduced accuracy in fricative production. A similar, but not significant, trend was found for the STN-DBS group. PMID:25333411

Eklund, Elisabeth; Qvist, Johanna; Sandström, Lena; Viklund, Fanny; Van Doorn, Jan; Karlsson, Fredrik

2015-02-01

122

DESCRIPCIÓN Y RESULTADOS DE VARIOS MÉTODOS DE MUESTREO PARA LA DETECCIÓN Y CENSO DE LOBO IBÉRICO ( Canis lupus signatus) EN UNA ZONA DE MONTAÑA  

Microsoft Academic Search

RESUMEN Se describen y valoran varios métodos de muestreo en una zona de montaña ubicada en el Parque Nacional Picos de Europa. Los muestreos están basados en métodos indirectos para la localización de indicios, con el objetivo de determinar presencia-ausencia y cuantificar la abundancia relativa, y en métodos directos para confirmar presencia de grupos familiares, éxito reproductivo y estimar el

L. LLANEZA; M. RICO; Y J. IGLESIAS

123

Articulatory Closure Proficiency in Patients with Parkinson's Disease Following Deep Brain Stimulation of the Subthalamic Nucleus and Caudal Zona Incerta  

ERIC Educational Resources Information Center

Purpose: The present study aimed at comparing the effects of deep brain stimulation (DBS) treatment of the subthalamic nucleus (STN) and the caudal zona incerta (cZi) on the proficiency in achieving oral closure and release during plosive production of people with Parkinson's disease. Method: Nineteen patients participated preoperatively and…

Karlsson, Fredrik; Olofsson, Katarina; Blomstedt, Patric; Linder, Jan; Nordh, Erik; van Doorn, Jan

2014-01-01

124

RACEMIZATION OF METEORITIC AMINO ACIDS. B. A. Cohen1 and C. F. Chyba, The University of Ari-zona, Tucson AZ 85719 1bcohen@lpl.arizona.edu.  

E-print Network

RACEMIZATION OF METEORITIC AMINO ACIDS. B. A. Cohen1 and C. F. Chyba, The University of Ari- zona, Tucson AZ 85719 1bcohen@lpl.arizona.edu. Amino acids are the building blocks of proteins, among the most biologically critical molecules. It was first noted in the 1800's that the vast majority of amino acids used

Cohen, Barbara Anne

125

CUANDO LA REVOLUCIÓN LLEGÓ AL CAMPO La política agraria sandinista, su debate y su impacto en las zonas rurales del interior  

Microsoft Academic Search

This article analyses the agrarian policies developed and implemented by the Sandinista administration in Nicaragua during the 1980's. It exposes the debate within organizations entrusted with transforming the agrarian sector between those who favoured peasant production and those who favoured industrialised farming. Finally, the article considers the impact of these policies on rural societies on the frontier of colonization in

Salvador Martí

1997-01-01

126

Acuerdo del Programa del Mal Comportamiento Nombre del Nio: _______________________ Fecha_____________________  

E-print Network

: _______________________ Fecha_____________________ Nombre del padre_______________________ Problemas de la conducta son niño es capaz a esta edad de aprender esta conducta? Sí____ No____ ¿Se portan los otros niños de la misma edad con la conducta deseada? Sí_____ No_____ Si el niño nunca se ha portado con la conducta

127

EVALUACIN DEL IMPACTO AMBIENTAL  

E-print Network

EVALUACIÓN DEL IMPACTO AMBIENTAL Grado en Ciencias Ambientales Universidad de Alcalá Curso DEL IMPACTO AMBIENTAL Código: 670020 Titulación en la que se imparte: Grado en Ciencias Ambientales que se imparte: Español 1. PRESENTACIÓN La evaluación de impacto ambiental de proyectos es un

Espigares, Tíscar

128

MEMORIA DEL DEPARTAMENTO  

E-print Network

ESCUELA UNIVERSITARIA Masó Pareja, Alfredo - 4 - #12;Memoria del Departamento de Fundamentos del Análisis. Mariscal Arlabán, Asier, doctor por la University of Chicago. Martínez Gorricho, Silvia, doctora por la Chicago. Turino, Francesco, doctor por la Universitat Pompeu Fabra. PROFESORES ASOCIADOS Ariza Jiménez

Escolano, Francisco

129

Deep Brain Stimulation of Caudal Zona Incerta and Subthalamic Nucleus in Patients with Parkinson's Disease: Effects on Voice Intensity  

PubMed Central

Deep brain stimulation of the subthalamic nucleus (STN-DBS) in patients with Parkinson's disease (PD) affects speech inconsistently. Recently, stimulation of the caudal zona incerta (cZi-DBS) has shown superior motor outcomes for PD patients, but effects on speech have not been systematically investigated. The aim of this study was to compare the effects of cZi-DBS and STN-DBS on voice intensity in PD patients. Mean intensity during reading and intensity decay during rapid syllable repetition were measured for STN-DBS and cZi-DBS patients (eight patients per group), before- and 12 months after-surgery on- and off-stimulation. For mean intensity, there were small significant differences on- versus off-stimulation in each group: 74.2 (2.0)?dB contra 72.1 (2.2)?dB (P = .002) for STN-DBS, and 71.6 (4.1)?dB contra 72.8 (3.4)?dB (P = .03) for cZi-DBS, with significant interaction (P < .001). Intensity decay showed no significant changes. The subtle differences found for mean intensity suggest that STN-DBS and cZi-DBS may influence voice intensity differently. PMID:22028987

Lundgren, Sofie; Saeys, Thomas; Karlsson, Fredrik; Olofsson, Katarina; Blomstedt, Patric; Linder, Jan; Nordh, Erik; Zafar, Hamayun; van Doorn, Jan

2011-01-01

130

Deep Brain Stimulation of Caudal Zona Incerta and Subthalamic Nucleus in Patients with Parkinson's Disease: Effects on Diadochokinetic Rate  

PubMed Central

The hypokinetic dysarthria observed in Parkinson's disease (PD) affects the range, speed, and accuracy of articulatory gestures in patients, reducing the perceived quality of speech acoustic output in continuous speech. Deep brain stimulation (DBS) of the subthalamic nucleus (STN-DBS) and of the caudal zona incerta (cZi-DBS) are current surgical treatment options for PD. This study aimed at investigating the outcome of STN-DBS (7 patients) and cZi-DBS (7 patients) in two articulatory diadochokinesis tasks (AMR and SMR) using measurements of articulation rate and quality of the plosive consonants (using the percent measurable VOT metric). The results indicate that patients receiving STN-DBS increased in articulation rate in the Stim-ON condition in the AMR task only, with no effect on production quality. Patients receiving cZi-DBS decreased in articulation rate in the Stim-ON condition and further showed a reduction in production quality. The data therefore suggest that cZi-DBS is more detrimental for extended articulatory movements than STN-DBS. PMID:22007342

Karlsson, Fredrik; Unger, Elin; Wahlgren, Sofia; Blomstedt, Patric; Linder, Jan; Nordh, Erik; Zafar, Hamayun; van Doorn, Jan

2011-01-01

131

Deep brain stimulation of caudal zona incerta and subthalamic nucleus in patients with Parkinson's disease: effects on diadochokinetic rate.  

PubMed

The hypokinetic dysarthria observed in Parkinson's disease (PD) affects the range, speed, and accuracy of articulatory gestures in patients, reducing the perceived quality of speech acoustic output in continuous speech. Deep brain stimulation (DBS) of the subthalamic nucleus (STN-DBS) and of the caudal zona incerta (cZi-DBS) are current surgical treatment options for PD. This study aimed at investigating the outcome of STN-DBS (7 patients) and cZi-DBS (7 patients) in two articulatory diadochokinesis tasks (AMR and SMR) using measurements of articulation rate and quality of the plosive consonants (using the percent measurable VOT metric). The results indicate that patients receiving STN-DBS increased in articulation rate in the Stim-ON condition in the AMR task only, with no effect on production quality. Patients receiving cZi-DBS decreased in articulation rate in the Stim-ON condition and further showed a reduction in production quality. The data therefore suggest that cZi-DBS is more detrimental for extended articulatory movements than STN-DBS. PMID:22007342

Karlsson, Fredrik; Unger, Elin; Wahlgren, Sofia; Blomstedt, Patric; Linder, Jan; Nordh, Erik; Zafar, Hamayun; van Doorn, Jan

2011-01-01

132

Use of porcine zona pellucida (PZP) vaccine as a contraceptive agent in free-ranging tule elk (Cervus elaphus nannodes).  

PubMed

The potential for the application of porcine zona pellucida (PZP) immunocontraception in wildlife population management has been tested over a 15 year period and promises to provide a useful wildlife management tool. These studies have provided evidence indicating that the use of PZP immunocontraception in wildlife: (i) is effective at both the physiological and population level (Liu et al., 1989; Kirkpatrick et al., 1996; Turner et al., this supplement); (ii) is deliverable by remote means (Kirkpatrick et al., 1990; Shideler, 2000); (iii) is safe in pregnant animals (Kirkpatrick and Turner, this supplement); (iv) is reversible (Kirkpatrick et al., 1991; Kirkpatrick and Turner, this supplement); (v) results in no long-term debilitating health problems (Kirkpatrick et al., 1995; Turner and Kirkpatrick, this supplement); (vi) has no implications for passage through the food chain (Harlow and Lane, 1988); and (vii) is reasonably inexpensive (J. F. Kirkpatrick, personal communication). This report presents the results of a 5 year study in tule elk (Cervus elaphus nannodes), 3 years of which were on the application of PZP immunocontraception to an expanding elk population living in a wilderness area of Point Reyes National Seashore in Marin County, CA, where hunting is not allowed and culling is not publicly acceptable. PMID:12220156

Shideler, S E; Stoops, M A; Gee, N A; Howell, J A; Lasley, B L

2002-01-01

133

Reversibility of action and safety during pregnancy of immunization against porcine zona pellucida in wild mares (Equus caballus).  

PubMed

Contraceptive management of publicly valued wildlife species requires safeguards to ensure that these populations are preserved in a healthy state. In addition, reversibility of contraceptive effects and safety in pregnant animals are major concerns. A population of wild horses has been immunized against porcine zona pellucida (PZP) over a 12 year period on Assateague Island National Seashore, MD (ASIS). Mares initially received one or two 65 microg inoculations and once a year 65 microg booster inoculations, all delivered by dart. All young mares aged > 2 years were treated with PZP for 3 consecutive years regardless of whether they have bred successfully and they were then removed from treatment until they had foaled. All mares vaccinated for 1 or 2 consecutive years became fertile again and 69% of mares treated for 3 consecutive years returned to fertility. All five mares treated for 4 or 5 consecutive years have also returned to fertility, but over longer periods of time. Mares treated for 7 consecutive years have not returned to fertility, but several, while still infertile, have started ovulating again. There was no difference in survival rates between foals born to treated and untreated mares, and PZP treatment of pregnant mares did not affect subsequent fertility of their female offspring. PMID:12220160

Kirkpatrick, J F; Turner, A

2002-01-01

134

Cysteine analogs with a free thiol group promote fertilization by reducing disulfide bonds in the zona pellucida of mice.  

PubMed

Archives of cryopreserved sperm harvested from genetically engineered mice, in mouse resource centers, are a readily accessible genetic resource for the scientific community. We previously reported that exposure of oocytes to reduced glutathione (GSH) greatly improves the fertilization rate of frozen-thawed mouse sperm. Application of GSH to in vitro fertilization techniques is widely accepted as a standard protocol to produce sufficient numbers of mice from cryopreserved sperm. However, the detailed mechanism of the enhancement of fertilization mediated by GSH in vitro is not fully understood. Here we focused on the chemical by determining the effects of its amino acid constituents and cysteine analogs on the fertilization of oocytes by frozen-thawed sperm. Furthermore, we determined the stability of these compounds in aqueous solution. We show here that l-cysteine (l-Cys), d-cysteine (d-Cys), or N-acetyl-l-cysteine (NAC) increased the rate of fertilization when added to the medium but did not adversely affect embryo development in vitro or in vivo. The levels of thiol groups of proteins in the zona pellucida (ZP) and the expansion of the ZP were increased by l-Cys, d-Cys, and NAC. These effects were abrogated by the methylation of the thiol group of l-Cys. NAC was the most stable of these compounds in the fertilization medium at 4°C. These results suggest that the thiol groups of cysteine analogs markedly enhance the fertilization rate of mouse oocytes. PMID:25715791

Takeo, Toru; Horikoshi, Yuka; Nakao, Satohiro; Sakoh, Kazuhito; Ishizuka, Yuta; Tsutsumi, Aki; Fukumoto, Kiyoko; Kondo, Tomoko; Haruguchi, Yukie; Takeshita, Yumi; Nakamuta, Yuko; Tsuchiyama, Shuuji; Nakagata, Naomi

2015-04-01

135

An alternative medicine study of herbal effects on the penetration of zona-free hamster oocytes and the integrity of sperm deoxyribonucleic acid  

Microsoft Academic Search

Objective: To analyze the effects of certain herbs on sperm DNA and on the fertilization process.Design: Prospective comparative study.Setting: Clinical and academic research environment.Patient(s): Donor sperm specimens.Intervention(s): Zona-free hamster oocytes were incubated for 1 hour in saw palmetto (Serenoa repens), echinacea purpura, ginkgo biloba, St. John’s wort (Hypericum perforatum), or control medium before sperm-oocyte interaction. The DNA of herb-treated sperm

Richard R. Ondrizek; Philip J. Chan; William C. Patton; Alan King

1999-01-01

136

Sperm capacitation in the domestic cat (Felis catus) and leopard cat (Felis bengalensis) as studied with a salt-stored zona pellucida penetration assay  

Microsoft Academic Search

The ability of domestic cat or leop- ard cat spermatozoa to penetrate zonae pellucidae (ZP) of salt-stored, domestic cat oocytes was examined as an assay for sperm capacitation. Ovarian oocytes were recov- ered after ovariectomy and matured in vitro for 18-36 h. Following removal of cumulus cells, the oocytes were used fresh, or stored (4°C, 0.5-24 weeks) in a HEPES-buffered

J. C. Andrews; J. G. Howard; B. D. Bavister; D. E. Wildt

1992-01-01

137

Effects of angiotensin II, adrenocorticotropin, and potassium on aldosterone production in adrenal zona glomerulosa cells from streptozotocin-induced diabetic rats.  

PubMed

Hyporeninemic hypoaldosteronism has been shown to occur in streptozotocin-induced chronic diabetic rats with normokalemia. To test the nature of the aldosterone deficiency, we investigated the responses of aldosterone production to angiotensin II (AII), ACTH, and potassium in adrenal zona glomerulosa cells from diabetic rats at 6 weeks after an injection of streptozotocin compared with those in the cells from control rats. In diabetic rats, plasma glucose was high and plasma immunoreactive insulin was low. Diabetic rats also had low levels of PRA and plasma AII, low levels of plasma aldosterone, and normal levels of plasma corticosterone and plasma potassium. The zona glomerulosa width was narrower in diabetic rats than in control rats. Basal aldosterone production, when corrected to an uniform number of cells per group, was similar in the cells from control and diabetic rats. Cells from diabetic rats showed a less sensitive and lower response of aldosterone production to AII, increases in the threshold and the ED50, and a decrease in the maximal AII-stimulated aldosterone level. ACTH, however, caused a similar effect on aldosterone production in the cells from control and diabetic rats. Cells from diabetic rats exhibited a less sensitive response of aldosterone production to potassium and a tendency to be low in the maximal potassium-stimulated aldosterone level, presumably attributable to the impairment of adrenal zona glomerulosa cells to AII. We conclude that the hypoaldosteronism observed in our diabetic rats may be secondary to the deficiency of AII. PMID:3000733

Kigoshi, T; Imaizumi, N; Azukizawa, S; Yamamoto, I; Uchida, K; Konishi, F; Morimoto, S

1986-01-01

138

Effect of the size of zona pellucida opening by laser assisted hatching on clinical outcome of frozen cleaved embryos that were cultured to blastocyst after thawing in women with multiple implantation failures of embryo transfer: a retrospective study  

PubMed Central

Purpose To evaluate the effect of the size of zona pellucida opening by laser assisted hatching for frozen cleaved embryo that were thawed after both fresh and frozen cleaved embryo transfer cycles failed and were cultured to blastocyst after thawing in patients with multiple implantation failures. Materials and methods Of 101 consecutive procedures (October 2003 to June 2006), 30 patients declined to perform assisted hatching and were selected as control group, 40 patients had 40 ?m opening of the zona (October 2003 to January 2005), 31 patients had 50% of the zona opening (February 2005 to June 2006). Results The pregnancy, implantation and delivery rates were significantly higher in 50% opening group (74%, 52% and 65%) compared to control group (17%, 10% and 13%; P?zona pellucida opening may affect the outcome of frozen cleaved embryo transfer. PMID:18365308

Fuchiwaki, Megumi; Hiraoka, Kaori; Horiuchi, Toshitaka; Murakami, Tomoyo; Kinutani, Masayuki; Kinutani, Kazuo

2008-01-01

139

Hojas informativas del NCI  

Cancer.gov

La colección de hojas informativas del NCI trata de una variedad de temas relacionados con el cáncer. Las hojas informativas se revisan y ponen al día de acuerdo a las investigaciones más recientes sobre el cáncer.

140

Fisiopatología del estreñimiento  

Microsoft Academic Search

ResumenEl estreñimiento es un trastorno extremadamente frecuente en la infancia, responsable de hasta el 25% de todas las consultas gastroenterológicas pediátricas y el 3% de todas las consultas pediátricas ambulatorias. En el 90% de los casos el origen del trastorno es funcional y sólo en un 10% existe un problema orgánico subyacente. Entre las causas orgánicas corrientes del estreñimiento infantil

Peter J. Milla

2007-01-01

141

Il problema del litio.  

NASA Astrophysics Data System (ADS)

Contents: 1. Introduzione. 2. La nucleosintesi del Big Bang. 3. Il litio nelle stelle di popolazione II. 4. I modelli stellari standard. 5. Il litio negli ammassi aperti. 6. Meccanismi di distruzione "non standard". 7. I modelli non-standard applicati alla popolazione II. 8. L'evoluzione Galattica del litio. 9. Quali stelle producono litio? 10. Il litio come elemento chiave per dare un nome agli oggetti stellari più minuscoli. 11. Conclusioni.

D'Antona, F.

1995-03-01

142

Control del cáncer y salud mundial: noticia del Instituto Nacional del Cáncer (NCI)  

Cancer.gov

En combinación con una reunión de alto nivel de las Naciones Unidas sobre enfermedades no transmisibles en países en vías de desarrollo, el doctor Harold Varmus, director del NCI, y el doctor Ted L. Trimble, del NCI, han publicado un comentario en Science Translational Medicine sobre “La integración del control del cáncer en la salud mundial" (Integrating Cancer Control into Global Health).

143

Motor afferents from the cerebellum, zona incerta and substantia nigra to the mediodorsal thalamic nucleus in the rat.  

PubMed

The mediodorsal (MD) thalamic nucleus provides information from subcortical structures to the prefrontal cortex. The human MD thalamic nucleus has been implicated in a great variety of different clinical conditions and normal functions ranging from schizophrenia, Parkinsonism and epilepsy to many cognitive functions. In the rat the MD thalamic nucleus is divided into three cytoarchitectonic sectors whereas in the primates it is divided into two; medial one-third (magnocellular) and lateral two-thirds further the lateral sector is divided into pars parvocellularis pars multiformis, pars fasciculosa and pars caudalis. In this study we used a retrograde tracer, fluoro-gold (FG) to evaluate some of the afferents reaching the lateral sector of the MD (MDl) thalamic nucleus. The results of the present study have shown that MDl receives afferent connections from the lateral cerebellar nucleus (dentate nucleus), substantia nigra pars reticulata (SNR) and zona incerta (ZI). Subsequent to FG injections into the MDl, labeled cells were observed mainly bilaterally but were sparser on the contralateral side than ipsilaterally from each of the three structures listed. All three afferents showed a topographical organization. The labeled neurons were localized at the dorsomedial aspect of the lateral cerebellar nucleus, the dorsoventral aspect of the SNR and in the dorsal sector of the ZI. The lateral cerebellar nucleus reached the MDl via the superior cerebellar peduncle. No other deep cerebellar nuclei showed labeled cells. There were no labeled cells in the substantia nigra pars compacta (SNC). Although the three regions identified here are recognized as having motor functions, the connections to MD suggest that their outputs also play a role in cognitive or other higher cortical functions. PMID:25164360

Çavdar, Safiye; Özgür, Merve; Uysal, Sanem P?nar; Amuk, Özge Ceren

2014-12-01

144

Roles of GABAA and GABAB receptors in regulating thalamic activity by the zona incerta: a computational study.  

PubMed

The posterior thalamic nucleus (PO) is a higher order nucleus heavily implicated in the processing of somatosensory information. We have previously shown in rodent models that activity in PO is tightly regulated by inhibitory inputs from a GABAergic nucleus known as the zona incerta (ZI). The level of incertal inhibition varies under both physiological and pathological conditions, leading to concomitant changes in PO activity. These changes are causally linked to variety of phenomena from altered sensory perception to pathological pain. ZI regulation of PO is mediated by GABAA and GABAB receptors (GABAAR and GABABR) that differ in their binding kinetics and their electrophysiological properties, suggesting that each may have distinct roles in incerto-thalamic regulation. We developed a computational model to test this hypothesis. We created a two-cell Hodgkin-Huxley model representing PO and ZI with kinetically realistic GABAAR- and GABABR-mediated synapses. We simulated spontaneous and evoked firing in PO and observed how these activities were affected by inhibition mediated by each receptor type. Our model predicts that spontaneous PO activity is preferentially regulated by GABABR-mediated mechanisms, while evoked activity is preferentially regulated by GABAAR. Our model also predicts that modulation of ZI firing rate and synaptic GABA concentrations is an effective means to regulate the incerto-thalamic circuit. The coupling of distinct functions to GABAAR and GABABR presents an opportunity for the development of therapeutics, as particular aspects of incerto-thalamic regulation can be targeted by manipulating the corresponding receptor class. Thus these findings may provide interventions for pathologies of sensory processing. PMID:25143541

Park, Anthony; Hoffman, Kathleen; Keller, Asaf

2014-11-15

145

Estudio del CH interestelar  

NASA Astrophysics Data System (ADS)

El objetivo principal de este proyecto consiste en el estudio de la distribución y abundancia del CH en nubes interestelares a través de la observación de las líneas hiperfinas del CH en 3,3 GHz. El CH es una molécula de amplia distribución en el espacio interestelar y una de las pocas especies que han sido observadas tanto con técnicas de radio como ópticas. Desde el punto de vista tecnológico se ha desarrollado un cabezal de receptor que permitirá la realización de observaciones polarimétricas en la frecuencia de 3,3 GHz, con una temperatura del sistema de 60 K y un ancho de banda de 140 MHz, y que será instalado en el foco primario de la antena parabólica del IAR. El cabezal del receptor es capaz de detectar señales polarizadas, separando las componentes de polarización circular derecha e izquierda. Para tal fin el cabezal consta de dos ramas receptoras que amplificarán la señal y la trasladarán a una frecuencia más baja (frecuencia intermedia), permitiendo de esa forma un mejor transporte de la señal a la sala de control para su posterior procesamiento. El receptor además de tener características polarimétricas, podrá ser usado en el continuo y en la línea, utilizando las ventajas observacionales y de procesamiento de señal que actualmente posee el IAR.

Olano, C.; Lemarchand, G.; Sanz, A. J.; Bava, J. A.

146

DIANA: Anlisis del discurso para la comprensin del conocimiento  

E-print Network

DIANA: Análisis del discurso para la comprensión del conocimiento DIANA: DIscourse ANAlysis by the Spanish Ministry of Economy and Competitiveness. Paolo Rosso coordinates the DIANA project and leads

Rosso, Paolo

147

Single-treatment porcine zona pellucida immunocontraception associated with reduction of a population of white-tailed deer (Odocoileus virginianus).  

PubMed

Previous reports have demonstrated gradual reductions of white-tailed deer (Odocoileus virginianus) populations through immunocontraception, with stabilization occurring after 2-4 yr of treatment, and subsequent reductions of 6-10% annually. These studies employed porcine zona pellucida (PZP) vaccines that required two initial treatments and annual retreatments. From 2005 to 2010, 258 adult and yearling female deer on Fripp Island, South Carolina, were treated with one of several PZP preparations designed to produce 2+ yr of effective contraception with a single treatment. These included several preparations of SpayVac and of native PZP-adjuvant emulsion plus PZP and QA-21 in timed-release pellets. Deer were chemically immobilized, ear-tagged, and administered initial treatments by hand in February-March. Some treated deer were boosted remotely with PZP-adjuvant emulsion 1.5 - 4.5 yr after initial treatments. Ground-based distance sampling was used to estimate deer population density at Fripp Island, a resort community, and at a relatively undeveloped neighboring control site, Hunting Island. Most vaccine preparations tested reduced fawning rates by 75% to 95% for at least 1 yr. From 2005 to 2011, deer density on Fripp Island declined by 50%, from 72 deer/km(2) to 36 deer/km(2), an average annual reduction of 11%. In contrast, population density on the Hunting Island control site fluctuated between 2005 and 2011, averaging 23 deer/km(2) (range, 19-28 deer/km(2)). Population declines on Fripp Island were associated with an increase in the proportion of treated females and with a progressive decrease in winter fawn:doe ratios, from 1.21 fawns/doe in 2005 to 0.19 fawns/doe in 2010. Winter fawn:doe ratios averaged 1.36 fawns/doe (range, 0.84 - 1.62 fawns/doe) at the Hunting Island control site. Annual survivorship averaged approximately 79% among ear-tagged females. The rate at which deer populations diminished in association with PZP treatments on Fripp Island was higher than that seen at other study sites, although the reasons for the more rapid decline on Fripp Island are not well understood. PMID:24437087

Rutberg, Allen T; Naugle, Ricky E; Verret, Frank

2013-12-01

148

Inoculation of female American black bears (Ursus americanus) with partially purified porcine zona pellucidae limits cub production.  

PubMed

The present 2-year study investigated the feasibility of using porcine zona pellucidae (pZP) as antigen for immunocontraception in American black bears. Sows, 3-6 years of age, were administered either two doses of 250 microg pZP with Freund's adjuvant (n = 10) or adjuvant alone (n = 5), one in April and one in May, and were kept away from the boars until June. Serum samples were collected before injections and before denning (November). The presence of sows with cubs at side was observed during premature emergence from denning. First-year results indicated that anti-pZP antibody titres in vaccinated sows were 2.5-9.0-fold (range) higher compared with non-vaccinated sows and that the vaccinated sows were threefold less likely to become pregnant (P = 0.167). Control and vaccinated bears produced 1.6 and 0.2 cubs per sow, respectively (P = 0.06). The second-year study investigated the feasibility of using pZP sequestered in a controlled-release pellet and a water-soluble adjuvant (QS-21) to avoid regulatory problems associated with Freund's adjuvant. Sows in the treatment group (n = 22) were administered a single dose of an emulsion of 250 microg pZP and 150 microg QS-21 plus a pellet containing 70-90 microg pZP for delayed release as booster dose. Control sows (n = 5) received the QS-21 adjuvant in pellet alone. Serum samples were collected before inoculations (April) and before denning (November). Seven cubs were born to the five control sows, but none was born to the 22 vaccinated sows (P < 0.001). Anti-pZP antibody mean absorbance ratios in control sows remained at background levels, whereas vaccinated sows had ratios fourfold higher than controls. Two-dimensional polyacrylamide gel electrophoresis and immunohistochemical localisation confirmed immunoreactivity of sera from inoculated bears. We conclude that cub production in the American black bear can be effectively limited with either two injections of 250 microg pZP or a single inoculation of partially purified pZP sequestered in controlled-release pellets. PMID:17601409

Lane, V M; Liu, I K M; Casey, K; vanLeeuwen, E M G; Flanagan, D R; Murata, K; Munro, C

2007-01-01

149

Pruebas de Papanicolaou y del virus del papiloma humano (VPH)  

Cancer.gov

Hoja informativa que describe los exámenes selectivos de detección del cáncer de cérvix, los cuales incluyen la prueba de Papanicolaou y la prueba de los virus del papiloma humano. La hoja informativa incluye también información acerca de las pautas de exámenes de detección del cáncer de cérvix.

150

Publicacin en Internet de los Datos del Herbario del  

E-print Network

Publicación en Internet de los Datos del Herbario del Departamento de Biología del Recinto-MAPR · Upgrading and Internet publication of the Herbarium of the Department of Biology at the University of Puerto datos a través de la Internet. #12;Georeferenciación · Coordenadas e información obtenidas de la

Gilbes, Fernando

151

Instantánea del sarcoma de Kaposi  

Cancer.gov

Información sobre las tendencias de incidencia, mortalidad y financiamiento del NCI sobre el sarcoma de Kaposi; así como ejemplos de actividades del NCI y adelantos en la investigación de este tipo de cáncer.

152

Instantánea del cáncer de páncreas  

Cancer.gov

Información sobre las tendencias de incidencia, mortalidad y financiamiento del NCI sobre el cáncer de páncreas; así como ejemplos de actividades del NCI y adelantos en la investigación de este tipo de cáncer.

153

Instantánea del cáncer de pulmón  

Cancer.gov

Información sobre las tendencias de incidencia, mortalidad y financiamiento del NCI sobre el cáncer de pulmón; así como ejemplos de actividades del NCI y adelantos en la investigación de este tipo de cáncer.

154

Instantánea del cáncer de riñón  

Cancer.gov

Información sobre las tendencias de incidencia, mortalidad y financiamiento del NCI sobre el cáncer de riñón; así como ejemplos de actividades del NCI y adelantos en la investigación de este tipo de cáncer.

155

Instantánea del cáncer de tiroides  

Cancer.gov

Información sobre las tendencias de incidencia, mortalidad y financiamiento del NCI sobre el cáncer de tiroides; así como ejemplos de actividades del NCI y adelantos en la investigación de este tipo de cáncer.

156

Instantánea del cáncer de próstata  

Cancer.gov

Información sobre las tendencias de incidencia, mortalidad y financiamiento del NCI sobre el cáncer de próstata; así como ejemplos de actividades del NCI y adelantos en la investigación de este tipo de cáncer.

157

Instantánea del cáncer de endometrio  

Cancer.gov

Información sobre las tendencias de incidencia, mortalidad y financiamiento del NCI sobre el cáncer de endometrio; así como ejemplos de actividades del NCI y adelantos en la investigación de este tipo de cáncer.

158

Instantánea del cáncer de ovario  

Cancer.gov

Información sobre las tendencias de incidencia, mortalidad y financiamiento del NCI sobre el cáncer de ovario; así como ejemplos de actividades del NCI y adelantos en la investigación de este tipo de cáncer.

159

Instantánea del cáncer de vejiga  

Cancer.gov

Información sobre las tendencias de incidencia, mortalidad y financiamiento del NCI sobre el cáncer de vejiga; así como ejemplos de actividades del NCI y adelantos en la investigación de este tipo de cáncer.

160

Instantánea del cáncer de estómago  

Cancer.gov

Información sobre las tendencias de incidencia, mortalidad y financiamiento del NCI sobre el cáncer de estómago; así como ejemplos de actividades del NCI y adelantos en la investigación de este tipo de cáncer.

161

Instantánea del cáncer de esófago  

Cancer.gov

Información sobre las tendencias de incidencia, mortalidad y financiamiento del NCI sobre el cáncer de esófago; así como ejemplos de actividades del NCI y adelantos en la investigación de este tipo de cáncer.

162

Determinacion de periodos fundamentales del suelo mediante vibraciones ambientales en el municipio de Humacao, Puerto Rico  

NASA Astrophysics Data System (ADS)

La tecnica de Nakamura ha sido utilizada a nivel mundial para determinar periodos fundamentales del suelo. La tecnica consiste en calcular y graficar cocientes espectrales H/V de vibraciones ambientales registradas sobre el suelo. Mediciones de vibraciones ambientales fueron tomadas en 151 lugares dentro del municipio de Humacao, localizado al este de Puerto Rico. Los datos se procesaron utilizando espectros de Fourier y espectros de potencia. La tecnica fue validada al compararla con los resultados de cocientes espectrales H/V de registros de sismos debiles y tambien con una modelacion numerica realizada con datos de un ensayo "downhole". Las graficas de los cocientes espectrales H/V fueron divididas en casos y grupos, los cuales dependen de la facilidad para identificar el periodo fundamental pico y amplitudes en frecuencias menores de 1 Hz, respectivamente. Los resultados obtenidos con ambos espectros fueron comparados y se concluye que los mismos se complementan para proveer resultados mas confiables. Se crearon mapas de periodos fundamentales, factores de amplitud, isoperiodos y clasificacion sismica de sitio. Los mapas de isoperiodos fueron realizados en las zonas mas pobladas sobre depositos de suelo. El mapa de periodos fundamentales del suelo mostro buena correlacion con la geologia local. El mapa de clasificacion sismica derivado de periodos de sitio fue comparado con el mapa de clasificacion sismica derivado de barrenos geotecnicos. El mapa de clasificacion obtenido de periodos puede sobreestimar un poco algunas clasificaciones del suelo. Sin embargo, este mapa puede proveer un estimado aproximado de la velocidad de onda de corte promedio del suelo hasta una profundidad de 100 pies (30 metros).

Cintron Aponte, Rommel

163

Grupos financieros al servicio del rey de Espaa Fines del siglo XVII -principios del XVIII  

E-print Network

Grupos financieros al servicio del rey de España Fines del siglo XVII - principios del XVIII Existe, en un primer momento, bajo el ángulo casi exclusivo de los servicios financieros al Estado2 . La financieros, arrendamientos de impuestos, derechos señoriales o ingresos privados, suministro de víveres, de

Paris-Sud XI, Université de

164

Nevado del Huila, Columbia  

NASA Technical Reports Server (NTRS)

Nevado del Huila Volcano in Colombia is actually a volcanic chain running north to south, capped by a glacier. With peaks ranging in height from 2,600 to 5,780 meters (8,530 to 18,960 feet), Nevado del Huila is a stratovolcano composed of alternating layers of hardened lava, solidified ash, and volcanic rocks. Its first recorded eruption occurred in the mid-sixteenth century. The long-dormant volcano erupted again in mid-April 2007. A few months before the eruption, the Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER) on NASA's Terra satellite captured this image of Nevado del Huila, on February 23, 2007. In this image, the bright white area just east of the central summit is ice. Immediately west of the summit are bare rocks, appearing as blue-gray. West of those rocks, white reappears, but this patch of white results from clouds hovering in the nearby valley. In the east, the colors turn to brown (indicating bare rock) and bright green (indicating vegetation). ASTER photographed Nevado del Huila near the end of a long phase of quietude. On April 17, 2007, local authorities recorded seismic activity associated with rock fracturing on the volcano's central summit, according to the ReliefWeb Website. Activity intensified the following day with an eruption and mudflows, forcing thousands of nearby residents to evacuate. As the Associated Press reported, the eruption caused avalanches and floods that wiped away both houses and bridges. It marked the volcano's first recorded eruption since the Spanish colonized the area five centuries earlier. NASA image created by Jesse Allen, using data provided courtesy of the NASA/GSFC/MITI/ERSDAC/JAROS, and U.S./Japan ASTER Science Team.

2007-01-01

165

Temas y rumbos del teatro rural hispanoamericano del siglo XX.  

E-print Network

Argentina. Digno de encomio, pues, el esfuerzo de Buenaventura y Gene por continuar la tradición del teatro folklórico.3 En lo que atañe a las creencias y al temperamento del campesino criollo, los autores hispanoamericanos han dado en la escena un... hijo del patrón que abusó de la inocencia de su prometida. Sabe que el encuentro podría ser funesto. El hombre de campo es también supersticioso. A veces mezcla las creencias de orden supersticioso con las religiosas. La presencia de ciertas aves...

Neglia, Erminio G.

1971-10-01

166

Seroprevalence and risk factors of toxoplasmosis in cattle from extensive and semi-intensive rearing systems at Zona da Mata, Minas Gerais state, Southern Brazil  

PubMed Central

Background Concerning the infection of humans by T. gondii, limited efforts have been directed to the elucidation of the role of horizontal transmission between hosts. One of the main routes of transmission from animals to humans occurs through the ingestion of raw or insufficiently cooked meat. However, even though the detection of T. gondii in meat constitutes an important short-term measure, control strategies can only be accomplished by a deeper understanding of the epidemiology of toxoplasmosis. The present study aimed to investigate the seroprevalence of toxoplasmosis in cattle from Zona da Mata, Minas Gerais, Brazil, and to identify associated risk factors, through an epidemiological investigation. Methods The animals studied (Bos indicus, breed Nelore or Gir) were reared in the Zona da Mata micro-region and killed at a commercial slaughterhouse at Juiz de Fora, Minas Gerais state. The animals came from 53 cattle farms with extensive (predominantly pasture feeding management) or semi-intensive (food management based on grazing, salt mineral and feed supplementation) rearing systems. Blood samples were collected from 1200 animals, and assigned to Indirect Fluorescent Antibody Test. Results When analyzing IgG anti-T.gondii we found an overall seroprevalence of 2.68%. In Brazil prevalences vary from 1.03% to 60%. Although in the present study, the seroprevalence per animal is considered low compared to those observed in other studies, we found out that of the 53 farms analyzed, 17 (34.69%) had one or more positive cattle. It is a considerable percentage, suggesting that the infection is well distributed through the Zona da Mata region. The results of the epidemiological investigation showed that the main risk factors of Toxoplasma gondii infection are related to animal management and to the definive host. There was a relationship between the number of seropositive cattle and the presence and number of resident cats, presence and number of stray cats, presence of cats walking freely, rat control by using cats and feed storage. Conclusion These results may contribute to the development of preventive strategies in Brazil and other developing countries were extensive and semi-intensive cattle rearing systems are very widespread and the efforts to control this important zoonotic disease have attained little success. PMID:23800302

2013-01-01

167

Acerca del Centro para la Salud Mundial del NCI  

Cancer.gov

El Centro para la Salud Mundial (CGH) coordina y fija las prioridades en las actividades que lleva a cabo el Instituto Nacional del Cáncer a nivel mundial. Su objetivo es avanzar la investigación mundial del cáncer y reducir las muertes causadas por esta enfermedad.

168

Competitividad del sector del vidrio templado en Colombia  

Microsoft Academic Search

La industria nacional del vidrio templado es un sector en crecimiento, que necesita desarrollar ventajas competitivas como la innovación en sus procesos y productos a través de tecnología dura y blanda, y desplegar una logística integrada que permita la articulación de la cadena de valor y la orientación al cliente. Las empresas del sector vienen desarrollando, de acuerdo con su

Javier Mauricio Mendoza Paredes

2008-01-01

169

Vacunas contra los virus del papiloma humano  

Cancer.gov

Hoja informativa acerca de las vacunas contra los virus del papiloma humano (VPH) para prevenir infecciones con ciertos tipos de VPH, los cuales son la causa principal del cáncer de cuello del útero o cérvix.

170

modelado y analisis del transporte del herbicida glifosato  

E-print Network

(2) Departamento de Ingeniería del Terreno, Universidad Politécnica de Cataluña (España). (3) Department of ... tools for the study of water and contaminant transport in the unsaturated zone. ..... Dynamics of Fluids in Porous Media. Esevier ...

2001-03-12

171

Harold Varmus investido bajo juramento como 14.º director del Instituto Nacional del Cáncer  

Cancer.gov

Ganador del Premio Nobel, doctor Harold E. Varmus, prestó juramento hoy como 14.º director del Instituto Nacional del Cáncer (NCI).  "Es muy estimulante que estés de regreso con nosotros", dijo la secretaria del Departamento de Salud y Servicios Humanos Kathleen Sebelius en la ceremonia de toma de juramento. “Hoy se abre un nuevo capítulo para el Instituto Nacional del Cáncer”.

172

Antioxidantes y prevención del cáncer  

Cancer.gov

Hoja informativa acerca de los antioxidantes, sustancias que pueden proteger las células del daño causado por moléculas inestables conocidas como radicales libres. El daño de los radicales libres puede resultar en cáncer.

173

NOTICIAS DEL 24/Julio/08  

E-print Network

de la materia oculta del Universo "Estamos mirando a los cielos, y usando los instrumentos más instrumentos más grandes para ayudarnos a predecir qué sucederá con las cosas más pequeñas", dijo David Toback

Toback, David

174

Case Study: del Amo Bioventing  

EPA Science Inventory

The attached presentation discusses the fundamentals of bioventing in the vadose zone. The basics of bioventing are presented. The experience to date with the del Amo Superfund Site is presented as a case study....

175

Alberto del Pozo  

NSDL National Science Digital Library

The Cuban Heritage Collection of the University of Miami Libraries was a recipient of 17 original illustrations by Alberto del Pozo in 1998 from the Campilli family. "The Oricha Collection" is their gift, and it contains illustrations in pen, crayon, and ink and the collection "pays homage to the primary gods and goddesses that comprise the Afro-Cuban religion of Santer'a." The "Introduction" near the top of the page, is a good place for visitors to start learning about Pozo, who was a Parson's School of Design-trained, Cuban artist who died at the age of 47. The "Biographical Sketch" is worth looking at as well. Examples of his colorful, heavily patterned and symbolism-intensive drawings of Santeria gods and goddesses can be found in the link "Gallery". The description of each drawing is given in English and Spanish. Finally, visitors interested in more information on the Santeria, can look at the "Further Readings" link for authoritative books on the subject.

176

Transgene driving GFP expression from the promoter of the zona pellucida gene zpc is expressed in oocytes and provides an early marker for gonad differentiation in zebrafish.  

PubMed

Although mechanisms of sex differentiation have been studied intensely in mammals, insects, and worms, little is known about this process in lower vertebrates. To establish a marker for female gonad differentiation in zebrafish, we generated a transgenic line in which 412 bp from the promoter and 5' mRNA leader of the female-specific zebrafish zona pellucida gene zpc are fused to the coding region of green fluorescent protein (GFP). The zpc0.5:GFP transgene is expressed exclusively in oocytes, starting from the onset of female-specific differentiation, and closely resembles the expression pattern of the wild-type zpc. Strong GFP expression persists throughout oogenesis and is visible through the body wall of females. We have also characterized a putative upstream factor of zpc, FIGalpha, and show that distribution of FIGalpha RNA is compatible with its postulated role in the regulation of zpc. The zpc0.5:GFP transgenic line described here will be useful for studying oocyte development and the mechanisms that determine sex-specific gene expression in the zebrafish. It is also the first promoter characterized to date to drive stable and efficient expression specifically in the zebrafish female germline. PMID:14579378

Onichtchouk, Daria; Aduroja, Kristin; Belting, Heinz-Georg; Gnügge, Lara; Driever, Wolfgang

2003-11-01

177

PARAULES DEL RECTOR EN L'ACTE DE CELEBRACI DEL NADAL DEL 2008  

E-print Network

és el quart any que m'apropo a aquest faristol per desitjar-vos Bon Nadal i el millor per al proper aniversari de la Declaració Universal dels Drets Humans de les Nacions Unides. La declaració ­us en recomano, tot allò que causa la misèria dels humans: les guerres, la pobresa extrema, la crueltat. Uns versos de

Verschure, Paul

178

Inauguracin del "Frum del Mediterrneo" Alicante, 24 de marzo de 2004  

E-print Network

recordar a las víctimas del terror del 11 de marzo, a sus familiares y amigos, y en ellas a todas las nuestros malos sueños y presagios. Como negar que para muchos de nosotros, la percepción del islam por

Escolano, Francisco

179

Expression of a P-selectin Ligand in Zona Pellucida of Porcine Oocytes and P-selectin on Acrosomal Membrane of Porcine Sperm Cells. Potential Implications for Their Involvement in Sperm–Egg Interactions  

PubMed Central

The selectin family of cell adhesion molecules mediates initial leukocyte adhesion to vascular endothelial cells at sites of inflammation. O-glycan structural similarities between oligosaccharides from human leukocyte P-selectin glycoprotein ligand-1 (PSGL-1) and from zona pellucida glycoproteins of porcine oocytes indicate the possible existence of a P-selectin ligand in the zona pellucida. Here, using biochemical as well as morphological approaches, we demonstrate that a P-selectin ligand is expressed in the porcine zona pellucida. In addition, a search for a specific receptor for this ligand leads to the identification of P-selectin on the acrosomal membrane of porcine sperm cells. In vitro binding of porcine acrosome-reacted sperm cells to oocytes was found to be Ca2+ dependent and inhibitable with either P-selectin, P-selectin receptor–globulin, or leukocyte adhesion blocking antibodies against P-selectin and PSGL-1. Moreover, porcine sperm cells were found to be capable of binding to human promyeloid cell line HL-60. Taken together, our findings implicate a potential role for the oocyte P-selectin ligand and the sperm P-selectin in porcine sperm– egg interactions. PMID:9151678

Geng, Jian-Guo; Raub, Thomas J.; Baker, Carolyn A.; Sawada, Geri A.; Ma, Li; Elhammer, ?ke P.

1997-01-01

180

Características del viento en estrellas Be derivadas del perfil H?  

NASA Astrophysics Data System (ADS)

El estudio teórico de perfiles H? y su variabilidad en estrellas Be ha sido frecuentemente desarrollado en base a modelos de envolturas circunestelares inhomogéneas, donde la geometría del material es responsable de la forma del perfil dependiendo de la dirección de observación. Nosotros damos una interpretación alternativa y proponemos que la mayoría de las propiedades de esta línea tienen origen en la base de un viento estelar y de una estructura cromosférica anexa a la fotósfera. Encontramos que típicos perfiles H? en Be, como son los llamados pole-on y winebottle, pueden ser reproducidos cualitativamente sin recurrir a la existencia de una envoltura asimétrica. Analizamos como la línea H? permite identificar la posible estructura del viento en la región donde éste se inicia.

Rohrmann, R.; Cidale, L.

181

El libro del Relogio del Palacio de las Horas  

NASA Astrophysics Data System (ADS)

This paper resume the investigation entitled ``El libro del Relogio del Palacio de las Horas''. That consist in an edition of the original text of the book of the Clock of the Palace of the Hours from the Books of the knowledge of Astronomy of Alfonso X (Manuscript 156, Complutense University). And a description of the astronomical functionality of the Clock of the Palace of the Hours. It includes a geometric description of the positional astronomy on which the operation of the Palace is based.

Morales, J. D.

2009-08-01

182

Absence of donor-derived zona pellucida protein C homolog in the inner perivitelline layer of Peking duck (Anas platyrhynchos)-Japanese quail (Coturnix coturnix japonica) chimeras (Duails).  

PubMed

Avian blastodermal cells at stage X are used to produce interspecies chimeras for heterogenous poultry reproduction. However, recipient-derived inner perivitelline layer (IPVL)-enclosed donor-derived ova may affect the efficiency of germline transmission via chimera. Among the proteins in the IPVL, zona pellucida protein C (ZPC) plays an important role in sperm-egg binding and inducing the acrosome reaction. In the present study, Peking duck blastodermal cells at stage X were transferred into subgerminal cavities of Japanese quail embryos at the same stage. Fourteen female duck-quail chimeras (duails) were hatched and raised to sexual maturity. After being screened by PCR, 3 duails were selected for examination of donor-derived ZPC. A total of 152 IPVL protein samples from the individual eggs laid by the 3 duails then underwent a preliminary examination for the presence of donor-derived ZPC by means of SDS-PAGE, periodic acid-Schiff staining, and Western blotting. A novel 35-kDa ZPC, not observed in quail but in duck, was found in the IPVL of the duails. Further analysis of peptide mass fingerprinting of Peking duck ZPC, Japanese quail ZPC, and the 35-kDa duail ZPC by matrix-assisted laser desorption-ionization reflectron time-of-flight mass spectrometry revealed that the novel ZPC was an isoform of quail ZPC. Moreover, comparison of N-terminal amino acid sequences of these 3 ZPC confirmed that the 35-kDa quail ZPC had more amino acids at the N terminus than did native quail ZPC, and none of the donor-derived ZPC was found in the duails. These findings suggest that it would be difficult to obtain donor-derived offspring by natural mating of interspecies chimeras. PMID:18809869

Sha, J; Gao, J; Li, J; Zhao, Q; Tao, G; Zhao, C; Han, H; Mori, M; Li, Z

2008-10-01

183

Novel natriuretic peptide receptor/guanylyl cyclase A-selective agonist inhibits angiotensin II- and forskolin-evoked aldosterone synthesis in a human zona glomerulosa cell line.  

PubMed

We report the production of a novel human natriuretic peptide receptor/guanylyl cyclase A (hNPR-A)-selective agonist ANP [G9T, R11S, G16R] (sANP). This agonist has similar affinity to ANP for hNPR-A and 1,000-10,000-fold reduced affinity for the human natriuretic peptide clearance receptor (hNPR-C). sANP was used to directly test the hypothesis that hNPR-A mediates the inhibitory effect of natriuretic peptides on aldosterone generation in a human zona glomerulosa cell line, H295R. Human type A natriuretic peptide and sANP (10(-11) to 10(-6) M) resulted in concentration-dependent increases in cGMP levels and decreases in forskolin (100 nM)- and angiotensin II (5 nM)-induced aldosterone and pregnenolone production. These results revealed an inhibitory effect of both peptides on the agonist-stimulated conversion of cholesterol to pregnenolone (i.e., cytochrome P-450 cholesterol monooxygenase side-chain cleaving enzyme, EC 1.14.15.6). H295R cells also exhibited angiotensin II- and forskolin-evoked conversion of [3H]cortico-sterone to [3H]aldosterone (i.e., cytochrome P-450 steroid 11 beta-monooxygenase/aldosterone synthase, EC 1.14.15.4). Human type A natriuretic peptide and sANP (10(-7) M) inhibited the angiotensin II-stimulated late pathway but did not affect forskolin-facilitated conversion of corticosterone to aldosterone. Our results directly demonstrate inhibitory effects of hNPR-A-mediated signal transduction on cytochrome P-450 cholesterol monooxygenase side-chain cleaving enzyme and steroid 11 beta-monooxygenase/aldosterone synthase complex depending on the steroidogenic agonist used. PMID:8700153

Olson, L J; Lowe, D G; Drewett, J G

1996-08-01

184

Association of mutations in the zona pellucida binding protein 1 (ZPBP1) gene with abnormal sperm head morphology in infertile men.  

PubMed

Nearly 7% of men are afflicted by male infertility worldwide, and genetic factors are suspected to play a significant role in the majority of these patients. Although sperm morphology is an important parameter measured in the semen analysis, only a few genetic causes of teratozoospermia are currently known. The objective of this study was to define the association between alterations in the genes encoding the Golgi-associated PDZ- and coiled-coil motif containing protein (GOPC), the protein interacting with C kinase 1 (PICK1) and the acrosomal protein zona pellucida binding protein 1 (ZPBP1/sp38) with abnormal sperm head morphology in infertile men. Previous reports demonstrated that mice lacking Gopc, Pick1 and Zpbp1 are infertile due to abnormal head morphology. Herein, using our validated RNA-based method, we studied spermatozoal cDNA encoding the human GOPC, PICK1 and ZPBP1 genes in 381 teratozoospermic and 240 controls patients via direct sequencing. Among these genes, we identified missense and splicing mutations in the sperm cDNA encoding ZPBP1 in 3.9% (15/381) of men with abnormal sperm head morphology. These mutations were not observed in 240 matched controls and the dbSNP database (?(2) = 9.3, P = 0.002). In contrast, statistically significant and functionally relevant mutations were not discovered in the GOPC and PICK1 genes. In our study ZPBP1 mutations are associated with abnormal sperm head morphology, defined according to strict criteria, resembling the mouse Zpbp1 null phenotype. We hypothesize that missense mutations exert a dominant-negative effect due to altered ZPBP1 protein folding and protein:protein interactions in the acrosome. PMID:21911476

Yatsenko, Alexander N; O'Neil, Derek S; Roy, Angshumoy; Arias-Mendoza, Paola A; Chen, Ruihong; Murthy, Lata J; Lamb, Dolores J; Matzuk, Martin M

2012-01-01

185

Estudios de la Zona No Saturada del Suelo Vol. VIII. J.V. Girldez Cervera y F.J. Jimnez Hornero, 2007 UNA FUNCIN DE RETENCIN QUE INCLUYE LA REGIN DE SEQUEDAD EXTREMA EN  

E-print Network

ISOTERMA DE ADSORCIÓN DE BET O. Silva§ , J. Grifoll Grup de Recerca de Fenòmens de Transport, Departament d.silva@urv.cat y jordi.grifoll@urv.cat § Dirección actual: Instituto Jaume Almera de Ciencias de la Tierra, Consejo

Politècnica de Catalunya, Universitat

186

Diversidad forrajera del pasto banderita (Bouteloua curtipendula (Michx.) Torr.), en poblaciones de zonas áridas y semiáridas de México Forage diversity of sideoats grama (Bouteloua curtipendula (Michx.) Torr.) populations in arid and semiarid regions of Mexico  

Microsoft Academic Search

The objectives of the present study were to evaluate sideoats grama (Bouteloua curtipendula (Michx.) Torr.) populations, to set an ex situ plot, and to asses morphological diversity. From 2000 to 2003, 577 sideoats grama populations were collected in 13 Mexican States. In 177 established ecotypes, the following plant morphologic attributes were assessed: vigour, regrowth, forage texture, dry matter production potential,

Carlos Raúl Morales Nieto; Adrián Quero Carrillo; Alicia Melgoza Castillo; Martín Martínez Salvador; Pedro Jurado Guerra

2009-01-01

187

Rodent middens, a new method for Quaternary research in arid zones of South America [Paleomadrigueras de roedores, un nuevo me??todo para el estudio del Cuaternario en zonas a??ridas de Sudame??rica  

USGS Publications Warehouse

In arid and semi-arid regions of South America, historical evidence for climate and vegetation change is scarce despite its importance for determining reference conditions and rates of natural variability in areas susceptible to modern desertification. Normal lines of evidence, such as pollen stratigraphies from lakes, are either rare or unobtainable in deserts; studies of late Quaternary vegetation history are few and generally inconclusive. This gap in knowledge may be corrected with discovery and development of fossil rodent middens in rocky environments throughout arid South America. These middens, mostly the work of Lagidium, Phyllotis, Abrocoma and Octodontomys, are rich in readily identifiable plant macrofossils, cuticles and pollen, as well as vertebrate and insect remains. In the North American deserts, more than 2,500 woodrat (Neotoma) middens analyzed since 1960 have yielded a detailed history of environmental change during the past 40,000 years. Preliminary work in the pre-puna, Monte and Patagonian Deserts of western Argentina, the Atacama Desert of northern Chile/southern Peru, the Mediterranean matorral of central Chile, and the Puna of the Andean altiplano suggest a similar potential for rodent middens in South America. Here we borrow from the North American experience to synthesize methodologies and approaches, summarize preliminary work, and explore the potential of rodent midden research in South America.

Betancourt, J.L.; Saavedra, B.

2002-01-01

188

EL ROL DEL GNERO DENTRO DEL PROCESO DE APRENDIZAJE COLABORATIVO  

E-print Network

de sexo y la forma en que esto afecta las actividades colaborativas. En el presente trabajo se describen los resultados de un experimento desarrollado con el fin de establecer que la diferencia de sexo]. Varios estudios también han demostrado que las diferencias de sexo en el uso del computador están

Guerrero, Luis

189

El papel del estado en la construcción del desarrollo sostenible: el caso del turismo en el Caribe Insular  

Microsoft Academic Search

La discusión acerca de la pertinencia de la intervención estatal en el mercado ha sido reiterativa en la historia del pensamiento económico. El turismo es otro ejemplo de que la regulación es no sólo necesaria sino fundamental, para corregir las asimetrías de un mercado que está lejos de cumplir los supuestos que motivaron la teoría del interés individual y del

Johannie James Cruz

2009-01-01

190

Aggiornamento del Piano Forestale Regionale: obiettivi e  

E-print Network

31-01-2013 1 Aggiornamento del Piano Forestale Regionale: obiettivi e azioni da condividere Davide green economy 2. Settore forestale: una green economy o una grey economy? 3. La struttura del Piano 4

Pettenella, Davide

191

UNIVERSIDAD SIMON BOLIVAR SEDE DEL LITORAL  

E-print Network

UNIVERSIDAD SIMON BOLIVAR SEDE DEL LITORAL ESPECIALIZACIÓN EN TELECOMUNICACIONES DECANATO DE comportamiento de las empresas del sector de las Telecomunicaciones considerando aspectos tecnológicos, políticos comunicación. Las organizaciones y su entorno. 2.- Entorno económico de las telecomunicaciones. Nociones

Vásquez, Carlos

192

Instantánea del cáncer de cuello uterino  

Cancer.gov

Información sobre las tendencias de incidencia, mortalidad y financiamiento del NCI sobre el cáncer de cuello uterino; así como ejemplos de actividades del NCI y adelantos en la investigación de este tipo de cáncer.

193

Instantánea del cáncer de seno (mama)  

Cancer.gov

Información sobre las tendencias de incidencia, mortalidad y financiamiento del NCI sobre el cáncer de seno (mama); así como ejemplos de actividades del NCI y adelantos en la investigación de este tipo de cáncer.

194

Arquitectura del Sistema de Gestin del ancho de Banda y Proteccin (SGBP) para entornos de redes  

E-print Network

Arquitectura del Sistema de Gestión del ancho de Banda y Protección (SGBP) para entornos de redes}@eia.udg.es Resumen. En el presente artículo se describe la arquitectura de un sistema inte- gral de gestión del ancho 4 detalla la arquitectura propuesta del sistema. Por último, se presentan las conclusiones y futuros

Ortega, Eusebi Calle

195

Elementos estratégicos para afianzar y mejorar la competitividad del Valle del Cauca  

Microsoft Academic Search

El estudio de competitividad del departamento del Valle del Cauca aborda el análisis simultáneo de los factores competitivos que integran el desarrollo económico regional; desempeño de los sectores productivos, la inserción internacional del sector industrial, la infraestructura, el capital humano y social, el avance tecnológico, el medioambiente, y los recursos institucionales. El examen de los factores competitivos y su contraste

Manuel Guillermo Bonilla; Juan Carlos Ramírez J

2005-01-01

196

Las ganancias del comercio y el intercambio desigual en los modelos del comercio internacional  

Microsoft Academic Search

Se examina el problema del intercambio desigual de trabajo entre países desarrollados y en desarrollo y su vinculación con las condiciones del comercio de beneficio mutuo. Para ello se utilizan los principales modelos teóricos del comercio internacional basado en las ventajas comparativas, y se amplía al caso de dos factores el concepto de relación de intercambio de trabajo derivada del

Francisco Martínez Soler; Andrei Martínez Finkelshtein

2005-01-01

197

EVOLUZIONE-WEB -1 -Evoluzione del Web  

E-print Network

EVOLUZIONE-WEB - 1 - Evoluzione del Web (fonte prof. Polillo) #12;- 2 - L'evoluzione del web EVOLUZIONE-WEB · Dal primo sito Web (1991) il Web è in continua crescita, e in continua evoluzione tecnologia, il mercato, i comportamenti delle persone · Le fasi della storia del Web: Web 1.0, Web 2.0, il

De Antonellis, Valeria

198

La teoría General del Empleo  

Microsoft Academic Search

I. Comentarios sobre las cuatro discusiones en la edición anterior de puntos de la Teoría General, 209. - II. Ciertos puntos definitivos en los que el autor difiere con teorías anteriores, 212. – La teoría del interés expuesta de nuevo, 215. – Incertidumbres y fluctuaciones de la inversión, 217. – III. Demanda y oferta para la producción total, 219. –

John Maynard Keynes

2007-01-01

199

L'avifauna del Laghetto del Frassino (Peschiera del Garda, Verona, Veneto)  

Microsoft Academic Search

Ten years of ornithological research at Lake Frassino (located near Peschiera del Garda, Verona, Italy) have produced a check-list of the birds dwelling at this Site of Community Importance (S.I.C.) to be produced. Our surveys have revealed that this water basin where ducks stop al- most exclusively during the day represents, together with nearby Lake Garda, the most important wintering

MARCO MORBIOLI; MAURIZIO SIGHELE

200

Ayuda para usar el sitio web en español del Instituto Nacional del Cáncer  

Cancer.gov

Página de guía que le permite al lector entender la forma en que está organizado el sitio web del Instituto Nacional del Cáncer (NCI), las categorías de información disponibles y las políticas que rigen este sitio web.

201

Evolucin del desarrollo y del costo de los sistemas fotovoltaicos en el mundo y en Chile  

E-print Network

Evolución del desarrollo y del costo de los sistemas fotovoltaicos en el mundo y en Chile Pontificia Universidad Católica de Chile Escuela de Ingeniería Departamento de Ingeniería Eléctrica IEE3372............................................................................................ 28 SMA Solar Technology

Rudnick, Hugh

202

l contenido econmico del XVI Con-greso del Partido Comunista Chino  

E-print Network

Organiza- ción Mundial del Comercio; Pekín ha sido ele- gida sede de los Juegos Olímpicos del 2008; el PCCh internacional, sino que la propia estruc- tura interna se configura según las prioridades de una economía

García-Berthou, Emili

203

Propostes i despropòsits: aspectes del gonellisme  

Microsoft Academic Search

Estudi sobre l'origen i la pervivència del gonellisme. Els autors n'exposen les constants ideològiques, que van del conservadorisme a l'extrema dreta, i fan una completa relació de les seves plataformes de difusió. L'anàlisi minuciosa d'aquest fenomen els porta a considerar el lligam entre el dialectalisme primigeni i el secessionisme anticatalanista que en deriva, així com a constatar la importància del

Guillem Calaforra; Sebastià Moranta

2005-01-01

204

El astrologo y el Emperador del Ganges1 Nota preliminar  

E-print Network

El astr´ologo y el Emperador del Ganges1 Nota preliminar El explorador y aventurero Sir Richard~nos las Actas de las audiencias del Emperador del Ganges, pero apenas logr´o recopilar algunos de los comunicante: Las audiencias del Emperador del Ganges eran re- gistradas en Actas, con todo lujo de detalles

Fernández Gallardo, Pablo

205

Cirugía de los trastornos del comportamiento: el estado del arte  

PubMed Central

Introducción: La cirugía de los trastornos del comportamiento (CTC) se está convirtiendo en un tratamiento más común desde el desarrollo de la neuromodulación. Métodos: Este artículo es una revisión no sistemática de la historia, indicaciones actuales, técnicas y blancos quirúrgicos de la CTC. Dividimos su historia en 3 eras: la primera comienza en los inicios de la psicocirugía y termina con el desarrollo de las tícnicas estereotácticas, cuando comienza la segunda era. Ésta se caracteriza por la realización de lesiones estereotácticas. Nos encontramos transitando la tercera era, que comienza cuando la estimulación cerebral profunda (ECP) comienza a ser usada en CTC. Resultados: A pesar de los errores graves cometidos en el pasado, hoy en día, la CTC está renaciendo. Los trastornos psiquiátricos que se más frecuentemente se tratan con cirugía son: depresión refractaria, trastorno obsesivo-compulsivo y síndrome de Tourette. Además, algunos pacientes con agresividad fueron tratados quirúrgicamente. Hay varios blancos estereotácticos descriptos para estos trastornos. La estimulación vagal puede ser usada también para depresión. Conclusión: Los resultados de la ECP en estos trastornos parecen alentadores. Sin embargo, se necesitan más estudios randomizados para establecer la efectividad de la CTC. Debe tenerse en cuenta que una apropiada selección de pacientes nos ayudará a realizar un procedimiento más seguro así como también a lograr mejores resultados quirúrgicos, conduciendo a la CTC a ser más aceptada por psiquiatras, pacientes y sus familias. Se necesita mayor investigación en varios temas como: fisiopatología de los trastornos del comportamiento, indicaciones de CTC y nuevos blancos quirúrgicos. PMID:25165612

Yampolsky, Claudio; Bendersky, Damián

2014-01-01

206

EL ESTUDIO DEL PLUMBISMO EN DOANA Y OTROS HUMEDALES ANDALUCES  

E-print Network

azulón Anas platyrhynchos, y se detectaron intoxicaciones letales en ánsar común y ánade rabudo Anas acuta (Mateo et al., #12;6 1998). También se estudió la densidad de plomo en los suelos de las zonas

Figuerola, Jordi

207

El cultivo del fique en el Departamento de Santander  

Microsoft Academic Search

El fique es una planta originaria de la América Tropical, su cultivo se da de manera particular en las zonas andinas de Colombia, Venezuela y Ecuador, en nuestro país su siembra se realiza en la parte alta de la sierra templada y fría. El proceso de desfibración de la hoja se realizaba de forma manual y su hilado de igual

Amilcar Mojica Pimiento; Joaquín Paredes Vega

2006-01-01

208

La arquitectura del pastoreo: Uso del espacio y sistema de asentamientos en la Puna de Atacama (Susques)  

Microsoft Academic Search

RESUMEN El objetivo del trabajo es contribuir al conocimiento de la arquitectura del pastoreo en los Andes. El foco regio- nal del estudio es Huancar en el Departamento Susques (Jujuy, Argentina). En primer lugar se describen los sis- temas de asentamientos vinculados con las actividades pastoriles de Huancar y luego se presentan los esquemas del uso del espacio por parte

Barbara Göbel

2002-01-01

209

PROVA PRATICA Valutazione economica di un Piano attuativo del PRG  

E-print Network

PROVA PRATICA Valutazione economica di un Piano attuativo del PRG In presenza di un Piano attuativo'intera previsione volumetrica (commerciale e residenziale) del Piano attuativo, sia delle urbanizzazioni primarie e valutazione di compatibilita urbanistica del Piano attuativo #12;

Di Pillo, Gianni

210

Control del dolor: Apoyo para las personas con cáncer  

Cancer.gov

Libro sobre el control del dolor en pacientes con cáncer. Cubre los métodos y medicinas, así como los efectos físicos y emocionales del dolor. Es una adaptación cultural para el público de habla hispana del libro en inglés Pain Control.

211

Monsters begat by quantifiers? Fabio Del Prete  

E-print Network

Monsters begat by quantifiers? Fabio Del Prete CNRS Lab CLLE-ERSS Toulouse Sandro Zucchi apparent consequence of this approach is that quantifiers and s are monsters in Kaplan's sense. We argue-00965284,version1-24Mar2014 #12;F. Del Prete - S. Zucchi Monsters begat by quantifiers? While some

Paris-Sud XI, Université de

212

Fisiología del embarazo: Interacción materno-infantil  

Microsoft Academic Search

ResumenEn los últimos años los datos han demostrado de qué manera el bienestar vitalicio depende considerablemente del crecimiento y el desarrollo intrauterinos durante la vida dentro del útero. El crecimiento fetal puede alcanzar únicamente su potencial íntegro mediante una interacción adecuada y armonizada entre la madre, la placenta y el feto. Este delicado equilibrio puede ser alterado por varios factores

Irene Cetin; Manuela Cardellicchio

2010-01-01

213

Las culturas políticas del republicanismo histórico español  

Microsoft Academic Search

Desde la perspectiva teórica denominada «Giro cultural», hemos tratado de repensar la formación del movimiento republicano español durante el siglo XIX, el cual tradicionalmente ha sido concebido de forma unívoca. En realidad, varios movimientos sociales coexistieron dentro del republicanismo español. Al menos desde tres culturas políticas republicanas (socialismo jacobino, demosocialismo y demoliberalismo) fueron movilizadas las clases populares españolas y se

Román Miguel González

2004-01-01

214

Svelato il codice genetico del lievito enologico  

Microsoft Academic Search

Primi al mondo, i ricercatori del 'The Australian Wine Research Institute' hanno completato il sequenziamento del genoma di un lievito enologico, descrivendo le 'ricette vitali' che danno forma all'amico dell'enologo. Questa ricerca apre la strada allo sviluppo di nuovi ceppi di lievito, in grado di offrire soluzioni innovative per il problema degli arresti di fermentazione, e di aumentare la gamma

Anthony R. Borneman; Angus H. Forgan; Paul J. Chambers; Isak S. Pretorius

215

Aspectos macroeconómicos del plan de desarrollo  

Microsoft Academic Search

Poco después de la apertura, la economía inició un ciclo de crecimiento rápido y acumulación de déficits, seguido por otra etapa de correctivos monetarios que frenan el crecimiento, pero que no eliminan las causas del desiquilibrio. El Plan de Desarrollo reduce el déficit fiscal y es probable que la próxima fase de expansión dure 3 años, en lugar del año

Luis Lorente

1999-01-01

216

Aspectos generales del concepto “capital humano”  

Microsoft Academic Search

ReSUMeN El presente artículo es la síntesis del debate de los autores sobre las transformaciones organizacionales basadas en el creciente predominio de los activos intangibles, especialmente del capital humano, para comprender las organizaciones económicas actuales en medio de sus contextos altamente exigentes y variables, como resultado de la fase inicial de una investigación general sobre el factor trabajo de las

Camilo Ernesto Tinoco Bernal; Sylvia Melissa Soler Mantilla

2011-01-01

217

Banco de Proyectos del Decanato de Extensin  

E-print Network

bienes a precios solidarios o al costo Aporte en especies a programas sociales determinados por el apoyan la propuesta 10. Resumen del presupuesto del proyecto. (Monto en BsF) Indique el financiamiento requerido para que la idea pueda lograr los objetivos mencionados. Costo total de la propuesta Monto

Vásquez, Carlos

218

CAPÍTULO 4. ANÁLISIS DEL DISCURSO: DISCURSO DEL EMPERADOR HIROHITO CON MOTIVO DE LA RENDICIÓN DE JAPÓN DE LA GUERRA DEL PACÍFICO  

Microsoft Academic Search

El ACD se encuadra en el marco teórico del Análisis del Discurso, teoría que otorga al discurso la dimensión de práctica social. En el ACD se explota esta vertiente social del uso del lenguaje, profundizando en las relaciones sociales e ideológicas que se establecen entre el texto y el contexto. El discurso se concibe como un concepto tridimensional: discurso como

Raquel Rubio Martín

219

Downregulation of DNA Methyltransferase 1 in Zona-Free Cloned Buffalo (Bubalus bubalis) Embryos by Small Interefering RNA Improves In Vitro Development But Does Not Alter DNA Methylation Level.  

PubMed

Aberrant epigenetic reprogramming, especially genomic hypermethylation, is implicated as the primary reason behind the failure of the cloning process during somatic cell nuclear transfer (SCNT). We transfected one-cell-stage zona-free buffalo embryos produced by handmade cloning with 50?nM DNMT1 small interfering RNA (siRNA), using lipofectamine, to knockdown the DNA methyltransferase 1 (DNMT1) gene. siRNA treatment decreased (p<0.001) the expression level of DNMT1 mRNA and DNMT1 protein in the one-cell-stage embryos and increased (p<0.05) the blastocyst rate (52.3±1.3% vs. 45.3±2.5%) compared to that in the controls, but did not reduce the DNA methylation level similar to the in vitro-fertilized (IVF) embryos. It also increased (p<0.05) the relative mRNA abundance of P53 and CASPASE 3, but not that of HDAC1, DNMT1, and DNMT3a, in the blastocysts of the siRNA group compared to the controls. The global level of H3K18ac was higher (p<0.05) in the blastocysts of the siRNA group than in the controls, whereas that of H3K9ac and H3K27me3 was not significantly different between the two groups. In conclusion, lipofection can be successfully used for transfection of DNMT1 siRNA into one-cell-stage zona-free cloned buffalo embryos. It results in a concomitant decrease in the DNMT1 mRNA and protein levels in the one-cell-stage embryos. siRNA-mediated knockdown increases the blastocyst rate but does not alter the DNA methylation level. PMID:25826721

Selokar, Naresh L; Saini, Monika; Agrawal, Himanshu; Palta, Prabhat; Chauhan, Manmohan S; Manik, Radheysham; Singla, Suresh K

2015-04-01

220

Ley 45/2007, de 13Ley 45/2007, de 13 dede Diciembre,Diciembre, PARA EL DESARROLLO SOSTENIBLE DEL MEDIO RURALPARA EL DESARROLLO SOSTENIBLE DEL MEDIO RURAL  

E-print Network

agregación de municipios/entidades de menos de 30.000 h. y una densidad inferior a 100 h/km2 2. ZONA RURAL a revitalizar · Escasa densidad, de base agraria, baja renta, aislamiento ... ­ B) Zonas rurales intermedias · Densidad baja/media, algo diversificadas, niveles de renta medios/bajos, alejados de centros urbanos ­ C

Rey Benayas, José María

221

COMUNICATO STAMPA Analisi Applicata del Comportamento (ABA) ed Autismo  

E-print Network

COMUNICATO STAMPA Analisi Applicata del Comportamento (ABA) ed Autismo Data Scadenza: 10 giugno 2014 ANALISI APPLICATA DEL COMPORTAMENTO (ABA) ED AUTISMO L'Università di Salerno ha pubblicati i bandi trattamento dei bambini con autismo secondo i criteri del metodo ABA (Analisi Applicata del Comportamento). I

Costagliola, Gennaro

222

D.R. n. n. 5024 del 1.08.2011n. 5024 del 1.08.2011n. 5024 del 1.08.2011n. 5024 del 1.08.2011 ClasseClasseClasseClasse LM-6 -Biologia  

E-print Network

.08.2011 ClasseClasseClasseClasse LM-6 - Biologia Nome del corsoNome del corsoNome del corsoNome del corso BIOLOGIA AMBIENTALE Nome ingleseNome ingleseNome ingleseNome inglese ENVIRONMENTAL BIOLOGY Lingua in cui si/2010, art. 14) Obiettivi formativi qualificanti della classe: LM-6 Biologia I laureati nei corsi di laurea

Malerba, Donato

223

PROPUESTA DELIQUIDACIÓN DEL CONTRATO CONSTRUCCIÓN NUEVO ALCANTARILLADO DEBOCAGRANDE-CARTAGENA  

Microsoft Academic Search

El Centro de Investigaciones para el Desarrollo (CID) de la Facultad de Ciencias Económicas fue invitado para que emitiera un concepto técnico sobre la liquidación del contrato celebrado el 20 de agosto de 1998 entre el Departamento Administrativo de Valorización del Distrito de Cartagena (DAVD) y la Compañía Alcantarillado Bocagrande S.A. El objetivo del contrato es la construcción del nuevo

Jorge Ivan GonzalesBorrero; Edna Cristina del SocorroBonilla Sebá; German GuerreroChaparro

2005-01-01

224

Departament de Cincies del Mar i Biologia Aplicada Vdeo promoci estudis en Cincies del Mar  

E-print Network

Departament de Ciències del Mar i Biologia Aplicada Vídeo promoció estudis en Ciències del Mar en la província alacantina. Departament de Ciències del Mar i Biologia Aplicada #12;Magazine Oceà nº curs està orientat a gestors ambientals, investigadors, persones amb formació acadèmica en Biologia

Escolano, Francisco

225

UNIVERSIDAD SIMON BOLIVAR SEDE DEL LITORAL  

E-print Network

UNIVERSIDAD SIMON BOLIVAR SEDE DEL LITORAL ESPECIALIZACIÓN EN TELECOMUNICACIONES DECANATO DE POSTGRADO DENOMINACIÓN: CÓDIGO: ASIGNATURA: LABOR. DE TELECOMUNICACIONES TI-7341 REQUISITOS: H. TEORÍA: H Laboratorio de Telecomunicaciones, el estudiante deberá haber obtenido destrezas prácticas en los

Vásquez, Carlos

226

PROT. N. 00113811 Del 06 luglio 2006  

E-print Network

'anno 2006 dei bilanci di enti ed organismi pubblici, ivi comprese le Università e i Dipartimenti, relativi impegnate alla data di entrata in vigore del decreto. Lo stesso Decreto Legge dispone che le somme

Milano-Bicocca, Università

227

Balance del año teatral 1972 en Lima.  

E-print Network

universitarios como el de la Universidad Villarreal y el de la Universidad San Martín de Porres y con grupos universitarios voca- cionales, como son el TUNI (Teatro de la Universidad Nacional, de Ingeniería) el ISANM o grupo de teatro del Instituto Superior de...), 33-41. 12. El Ingeniero Arturo Nolte, también director de producción del Teatro Nacional Popular, quien gentilmente nos brindó esta información, en entrevista celebrada en Lima, el 8 de mayo de 1972 puso de relieve que los grupos universitarios...

Cajiao Salas, Teresa

1974-10-01

228

La evolucion del modernismo en Puerto Rico  

E-print Network

elementos estilis- ticos: la belleza plastica, la musicalidad, el croma- tismo, el sensualismo, el exotismo, la evasion, el sen- tido cosmopolita y el dualismo. El modernismo ademas in- novo la metrica mediante el uso de los siguientes metros: los... por resaltar lo exotico, lo extravagante y lo pictorico. Hace uso de la parodia y de la shtira, pero cuidando de la forma y del ritmo del verso. De igual modo, Amado Nervo ejercio su influencia mediante su poesia existencialista y espiri- tualista...

Gonzalez-Hernandez, Miriam Mercedes

1989-01-01

229

Reseña del VIII Festival Internacional de Teatro  

E-print Network

los diferentes medios del país. Este vacío que fue protuberante se debió a la falta de recursos económicos para sostener esta clase de invitados. Mas como efecto positivo se percibió que durante la semana del evento el Festival Internacional no giró... una acción viva que requiere de crónica aparte. El Teatro Taller de Colombia merece página aparte por la validez e importancia de su trabajo que es toda una propuesta que cobija factores de indudable calidad, en especial su "circo invisible" que...

Dí az, Né stor Gustavo

1986-10-01

230

Gonadal dysgenesis in del (18p) syndrome  

SciTech Connect

We report on a girl with syndromal gonadal dysgenesis and a de novo del (18p). Genetic factors controlling gonadal development are located not only on the X chromosome, but also on autosomes. The present case suggests that one of these genes is situated on 18p. We conclude that patients with del (18p) syndrome should be evaluated for gonadal dysgenesis. 16 refs., 3 figs.

Telvi, L.; Ion, A.; Fouquet, F. [Hospital Saint Vincent de Paul, Paris (France)] [and others

1995-07-17

231

Pgina 1 de 18 CDIGO DE CONDUCTA DEL CENTRO DE  

E-print Network

Página 1 de 18 C�DIGO DE CONDUCTA DEL CENTRO DE INVESTIGACION Y DE ESTUDIOS AVANZADOS DEL INSTITUTO CONDUCTA: I. Conocimiento y aplicación de las leyes y normas. 1 II. Uso del cargo público. 2 III. Uso y T�RMINOS. 13 #12;Página 2 de 18 C�DIGO DE CONDUCTA DEL CENTRO DE INVESTIGACION Y DE ESTUDIOS AVANZADOS DEL

232

Calidad de Imagen del Telescopio UNAM212  

NASA Astrophysics Data System (ADS)

El telescopio UNAM2l2, del Observatorio Astronómico Nacional, situado en la Sierra de San Pedro Mártir (Baja California, México), cumplira en un futuro muy cercano siete años de uso para fines de investigación astronómica. Aunque en este tiempo no se ha efectuado un estudio sistemático acerca de su comportamiento óptico y de los factores que influyen en la calidad de las imágenes, se han realizado pruebas diversas, estudios parciales y reuniones especificas, cuyos resultados no siempre se han difundido ampliamente y generalmente no se han presentado por escrito. Es por ello que hemos creido necesario intentar una recopilación de la información existente para poder con ella establecer un diagnóstjco que, aunque no sea definitivo, sirva de base para futuros trabajos tendientes a optimizar el comportamiento óptico del telescopio. Es evidente que un buen número de las conclusiones que se presentan son resultado del trabajo de muchas personas ó de esfuerzos colectivos. Asimismo, hemos tratado de localizar información bibliográfica que pueda ser de utilidad. Nuestro objetivo primordial ha consistido en centrarnos en la óptica del telescopio y su calidad, pero también se han considerado otros aspectos que puedan afectar las imágenes obtenidas tales como: celda del primario, `seeing' local y externo, flexiones posibles en la estructura mecánica del telescopio, etc.

Cobos, F. J.; Teiada de Vargas, C.

1987-05-01

233

Los orígenes del Partido del Socialismo Democrático (1989-1993): el ave fénix roja en Alemania  

Microsoft Academic Search

El Partido del Socialismo Democrático (Partei des Demokratischen Sozialismus), surgido de la descomposición interna del SED (Sozialistiscbe Einbeitspartei Deutschlands), es un caso relevante de adaptación de los partidos únicos en los regímenes comunistas a la democracia plurípar-tidista. Dadas las peculiaridades de la transición en la República Democrática de Alemania, acelerada por su rápida integración en la República Federal, el SED

Ricardo Martín de la Guardia

2005-01-01

234

Serie de Derecho Económico 1. Casos de estudio de aplicación del Análisis Económico del Derecho  

Microsoft Academic Search

El interés por el estudio del Análisis Económico del Derecho –AED– no es nuevo. En su versión clásica, que corresponde a la Escuela de Chicago, y también en las versiones más recientes como la nueva economía institucional, el AED resulta ser una herramienta útil para estudiar problemas jurídicos, la forma de incidir de la regulación en el desarrollo y en

Varios

235

Preguntas y respuestas acerca del Estudio del Tamoxifeno y Raloxifeno (STAR)  

Cancer.gov

El Estudio del Tamoxifeno y Raloxifeno (STAR, por sus siglas en inglés) es un estudio clínico (un estudio de investigación conducido con voluntarios) diseñado para ver cómo el medicamento raloxifeno (Evista®) se compara con el medicamento tamoxifeno (Nolvadex®) en reducir la incidencia de cáncer del seno en las mujeres con alto riesgo de desarrollar la enfermedad.

236

Experiencias en la incorporación del enfoque poblacional en la planeación del desarrollo territorial. Memorias  

Microsoft Academic Search

Este documento contiene las ponencias presentadas durante el Encuentro Experiencias en la incorporación del enfoque poblacional en la planeación del desarrollo territorial realizado en Bogotá los días 6 y 7 de noviembre de 2008 en la Universidad Externado de Colombia. El evento fue organizado por el Fondo de Población de las Naciones Unidas -UNFPA-, el Departamento Nacional de Planeación -DNP-,

Yolanda Bodnar Contreras

237

VI CONGRESO DEL CEISAL Toulouse, del 30 de junio al 3 de Julio de 2010  

E-print Network

-30Jun2010 #12;Identificación de fortalezas y debilidades del G8+5 ante la crisis energética 2 RESUMEN Cumbre 2008 de Ministros de Finanzas de la Mancomunidad Británica de Naciones celebrada del 6 al 8 de

Paris-Sud XI, Université de

238

Intertextual Sexual Politics: Illness and Desire in Enrique Gomez Carrillo's "Del amor", "del dolor y del vicio" and Aurora Caceres's "La rosa muerta"  

ERIC Educational Resources Information Center

This study explores the intertextuality between Aurora Caceres's "La rosa muerta" (1914) and the novel "Del amor, del dolor y del vicio" (1898) by her ex-husband, Enrique Gomez Carrillo. Caceres strategically mentions Gomez Carrillo's novel in "La rosa muerta" to invite a reading of her work in dialogue with his. Both narratives follow the sexual…

LaGreca, Nancy

2012-01-01

239

Balances energéticos y uso del sueloen la agricultura catalana: una comparación entre mediados del siglo XIX y finales del siglo XX  

Microsoft Academic Search

El presente trabajo analiza y compara, desde la perspectiva analítica del metabolismo social, los usos del suelo y los balances energéticos derivados de estos usos de los sistemas agrarios de cinco municipios de la comarca catalana del Vallès, en dos momentos históricos que ilustran las características y magnitud de las transformaciones que se han producido en los sistemas agrarios catalanes

Xavier Cussó; Ramon Garrabou; José Ramon Olarieta; Enric Tello

2006-01-01

240

Extensión del Formalismo de Orbitales de Defecto Cuántico al tratamiento del efecto Stark (SQDO).  

NASA Astrophysics Data System (ADS)

El estudio experimental de las interacciones de átomos Rydberg altamente excitados con campos eléctricos ha experimentado un creciente interés durante las dos últimas décadas debido, en gran medida, al desarrollo de nuevas técnicas para crear y estudiar átomos Rydberg en el laboratorio. Acompañando a estas nuevas técnicas experimentales, es necesario el desarrollo de modelos teóricos que nos permitan contrastar sus medidas y conocer mejor los fundamentos de los mismos. Desde el punto de vista teórico el conocimiento del desdoblamiento de los niveles energéticos de un átomo en función de la magnitud del campo eléctrico aplicado (lo que se conoce como mapa Stark) es el mejor punto de partida para la descripción del sistema y un prerrequisito fundamental para el cálculo de distintas propiedades atómicas en presencia del campo eléctrico tales como intensidades de transición, umbrales de ionización de campo eléctrico, tiempos de vida, posición y anchura de cruces evitados, etc. En este trabajo presentamos la adaptación del método de orbitales de defecto cuántico [1,2,3] al tratamiento del efecto Stark (SQDO) [4] y su aplicación al cálculo de los desdoblamientos energéticos y fuerzas de oscilador de estados Rydberg en los átomos de Li, Na y K. El propósito de este estudio es, por un lado, desarrollar métodos fiables para la determinación de propiedades atómicas en presencia de campos eléctricos y, por otro, mostrar la fiabilidad de las funciones de onda QDO en la descripción del efecto Stark en sistemas atómicos.

Menéndez, J. M.; Martín, I.; Velasco, A. M.

241

Angiotensin II triggers expression of the adrenal gland zona glomerulosa-specific 3?-hydroxysteroid dehydrogenase isoenzyme through de novo protein synthesis of the orphan nuclear receptors NGFIB and NURR1.  

PubMed

The 3?-hydroxysteroid dehydrogenase (3?-HSD) is an enzyme crucial for steroid synthesis. Two different 3?-HSD isoforms exist in humans. Classically, HSD3B2 was considered the principal isoform present in the adrenal. However, we recently showed that the alternative isoform, HSD3B1, is expressed specifically within the adrenal zona glomerulosa (ZG), where aldosterone is produced, raising the question of why this isozyme needs to be expressed in this cell type. Here we show that in both human and mouse, expression of the ZG isoform 3?-HSD is rapidly induced upon angiotensin II (AngII) stimulation. AngII is the key peptide hormone regulating the capacity of aldosterone synthesis. Using the human adrenocortical H295R cells as a model system, we show that the ZG isoform HSD3B1 differs from HSD3B2 in the ability to respond to AngII. Mechanistically, the induction of HSD3B1 involves de novo protein synthesis of the nuclear orphan receptors NGFIB and NURR1. The HSD3B1 promoter contains a functional NGFIB/NURR1-responsive element to which these proteins bind in response to AngII. Knockdown of these proteins and overexpression of a dominant negative NGFIB both reduce the AngII responsiveness of HSD3B1. Thus, the AngII-NGFIB/NURR1 pathway controls HSD3B1. Our work reveals HSD3B1 as a new regulatory target of AngII. PMID:25092869

Ota, Takumi; Doi, Masao; Yamazaki, Fumiyoshi; Yarimizu, Daisuke; Okada, Kazuki; Murai, Iori; Hayashi, Hida; Kunisue, Sumihiro; Nakagawa, Yuuki; Okamura, Hitoshi

2014-10-01

242

Student Competition: Siting Potential Dams at Camp Del Webb, Utah  

E-print Network

Siting Potential Dams at Camp Del Webb, Utah Presented By: Kyle Wamser Problem ? Camp Del Webb is Lacking an Onsite Lake ? High Adventure Bases generally need aquatics ? Large lake nearby, but transportation is required ? Possible Solution...

Wamser, William Kyle

2007-11-14

243

Polo Universitario Imperiese Scienze del turismo: impresa, cultura e territorio  

E-print Network

-PSI/01 Psicologia del turismo (mod. 1 con M-PSI/01) 6 caratterizzante BIO/08 Antropologia per il turismo (mod. 2 con BIO/08) 6 affini SPS/07 Sociologia del turismo 9 caratterizzante L-ART/05 Antropologia

Robbiano, Lorenzo

244

Transformación de los programas de estudios clínicos del NCI  

Cancer.gov

Información sobre los programas e iniciativas del NCI que patrocinan, realizan, crean o apoyan estudios clínicos, entre los que se incluyen la Red Nacional de Estudios Clínicos (NCTN) y el Programa de Investigación Oncológica Comunitaria (NCORP) del NCI.

245

Centro para la Salud Mundial (CGH) del NCI  

Cancer.gov

El Centro para la Salud Mundial (CGH) del Instituto Nacional del Cáncer coordina actividades de investigación y trabaja con socios nacionales e internacionales para comprender y enfrentar la carga que representa el cáncer a nivel mundial.

246

La reconstrucción del seno después de una mastectomía  

Cancer.gov

Hoja informativa que describe la reconstrucción del seno (mama) después de una mastectomía. Contiene información sobre las opciones quirúrgicas, los cuidados de seguimiento y los exámenes de detección del cáncer de seno después de la reconstrucción.

247

Manuel Garca Snchez-Colomer -1 Evaluacin del impacto ambiental  

E-print Network

Manuel García Sánchez-Colomer - 1 Evaluación del impacto ambiental Temas 12 - 13 Tema 13 Evaluación del impacto ambiental Temas 12 - 13 Factor del medio: medio biótico · Vegetación · Fauna terrestre ambiental Temas 12 - 13 Medio biótico: Vegetación ESTUDIO DE VEGETACIÓN DE RIBERA ­ ESTUDIO DE HÁBITATS DE

Espigares, Tíscar

248

Estrategias cognitivo-conductuales para el manejo del craving  

Microsoft Academic Search

En el presente trabajo se revisaron los aspectos genera- les del craving y se destacó su importancia para la adhe- rencia al tratamiento en adicciones. De igual manera se revisaron las diferentes estrategias cognitivo-conductua- les para el manejo del craving, las cuales incluían: detención del pensamiento, técnicas de distracción, con- trol y programación de actividades, entrenamiento en relajación, técnicas de

Iván González Salazar

2004-01-01

249

Guida alla compilazione del Piano economico on line  

E-print Network

Guida alla compilazione del Piano economico on line #12;Attenzione Questa guida fornisce indicazioni pratiche per la compilazione del Piano economico on line. Per avere indicazioni più generali sulla formulazione del Piano economico si raccomanda di fare riferimento a: Guida alla presentazione (http

De Cindio, Fiorella

250

Piano Lauree Scientifiche: Aspetti matematici del Rudiger Achilles  

E-print Network

Piano Lauree Scientifiche: Aspetti matematici del GPS R¨udiger Achilles Universit`a di Bologna Bologna, 3 Febbraio 2014 Piano Lauree Scientifiche: Aspetti matematici del GPS R¨udiger Achilles Bologna essere d. Piano Lauree Scientifiche: Aspetti matematici del GPS R¨udiger Achilles Bologna, 3 Febbraio

Achilles, Rüdiger

251

Hoja informativa sobre la calidad del aire interior  

E-print Network

promover la salud y la calidad de vida mediante la prevención y el control de las enfermedades, lasHoja informativa sobre la calidad del aire interior La mala calidad del aire interior proviene de de uso doméstico como limpiadores y pesticidas Cómo mejorar la calidad del aire interior · Abra las

252

EL TURISMO ELECTRÓNICO, UNA NECESIDAD PARA LAS EMPRESAS DEL SECTOR  

Microsoft Academic Search

La importancia y la necesidad de la utilización del Comercio Electrónico en la industria turística ayuda a mejorar las operaciones tradicionales practicadas en los negocios, tanto en la estrategia empresarial como en la reingeniería del negocio turístico. El hecho de que predominen las pequeñas y medianas empresas en el sector implica que la utilización del e-Commerce no se ha extendido

Ernesto Manuel Conde Pérez; Nel Enrique Cristian Schmidt Cornejo; Ileana Ochoa Llamas

2011-01-01

253

COMUNICATO STAMPA Nuove frontiere del Corso di Laurea in Fisioterapia  

E-print Network

in Fisioterapia intende promuovere un'ulteriore analisi della formazione universitaria del Fisioterapista rinnovamento importante della Formazione universitaria del Fisioterapista, non più ulteriormente differibile universitaria e nel profilo del Fisioterapista. E' stato richiesto l' accreditamento E.C.M. LA PARTECIPAZIONE AL

Costagliola, Gennaro

254

Departament de Filosofia del Dret i Dret Internacional Privat Presentaci  

E-print Network

Departament de Filosofia del Dret i Dret Internacional Privat Presentació El Departament de Filosofia del Dret i Dret Internacional Privat està compost per les següents àrees de coneixement: Tauler d Departament de Filosofia del Dret i Dret Internacional Privat preguen als seus alumnes que es comuniquen amb

Escolano, Francisco

255

Tratamiento biológico del lixiviado generado en el relleno sanitario \\  

Microsoft Academic Search

2 *d; además, este sistema presentó gran estabilidad frente a variaciones importantes en cuanto a las características del lixiviado y ausencia de olores desagradables. Los porcentajes de remoción de DQO en el reactor UASB eran muy variables, con picos bajos y caídas muy marcadas, que indican que no se presentaba un funcionamiento óptimo del proceso durante la mayor parte del

Alexander Álvarez Contreras; John Hermógenes; Suárez Gelvez

2006-01-01

256

Análisis del Proceso Software Basado en Modelos de Producción Industrial  

Microsoft Academic Search

La modelización del Proceso Software constituye un marco de referencia para la organización de las actividades que involucran todas las etapas del desarrollo, tendente a la resolución de problemas que el propio desarrollo de software plantea y genera a medida que evoluciona. La modelización del proceso se hace mas compleja a medida que el desarrollo tecnológico, metodológico y, fundamentalmente la

Alicia Mon

257

Recalibrando la medición del balance estructural en Chile  

Microsoft Academic Search

El presente resumen de políticas realiza una revisión sistemática de la metodología de estimación del Balance Estructural (BE) en Chile. Esta revisión no sólo recapitula y evalúa la justificación de la metodología de cálculo del BE actual o las pasadas, sino que explora diversas alternativas de mejoramiento, en la perspectiva de elevar la calidad, transparencia y estabilidad del BE como

Mario Marcel; Mabel Cabezas; Bernardita Piedrabuena

2012-01-01

258

ESPECIALIZACIN EN GESTIN AMBIENTAL Objetivo del programa  

E-print Network

ESPECIALIZACIÓN EN GESTIÓN AMBIENTAL Objetivo del programa La Especialización en Gestión Ambiental identificar, en un mundo cambiante, en lo social, en lo económico y en lo ambiental, las medidas de prevención, mitigación y resolución de problemas de carácter ambiental, a fin de contribuir con el desarrollo sostenible

Vásquez, Carlos

259

APUNTES PARA UN ESTUDIO DEL DISEÑO INDUSTRIAL  

Microsoft Academic Search

La máquina es quizá el factor dominante de nuestra época. Desde la primera mitad del XIX se desarrolla une nuevo sistema de acción sobre la materia y de producción de objetos permitiendo la multiplicación de objetos consecuencia de la producción en serie. El diseño industrial es así la forma característica de la producción de objetos de la sociedad industrial, es

Ignacio Casado Galván

2009-01-01

260

Exámenes selectivos de detección del cáncer colorrectal  

Cancer.gov

Un ejemplo excelente del poder de la investigación de prevención es el progreso sustancial que hemos logrado en la reducción de la incidencia y muerte por cáncer colorrectal, con nuevos conocimientos que iluminan el camino a incluso mayores reducciones en un futuro cercano.

261

Self Interacting Markov chains P. Del Moral  

E-print Network

-Sud Ouest, France 2 / 27 #12;Self interacting processes in biology and engineering Biology : Genetic type, bayesian learning, filtering, and spectral analysis of Feynman-Kac-Schroedinger operators. Some important-Boltzmann-Gibbs transformation : G : E [0, [ with µ(G) > 0 G (µ)(dx) = 1 µ(G) G(x) µ(dx) P. Del Moral (INRIA Bordeaux) INRIA

Del Moral , Pierre

262

Aproximaciones al análisis económico del derecho  

Microsoft Academic Search

Durante las últimas décadas la metodología de estudio que plantea el análisis económico del Derecho ha tomado gran importancia en todo el mundo,y es acompañada y respaldada por un prolífico volumen de publicaciones e investigadores, que día tras día la utilizan para evaluar los posibles caminos y consecuencias que las construcciones y desarrollos legales pueden tener sobre el comportamiento de

Mario A. Pinzón Camargo

263

VIII Encuentro Nacional de Teatro del CLETA  

E-print Network

músicos y cantantes. Unos gozan de más experiencia dentro del género y de más conocimiento técnico que otros; sin embargo, lo que está por encima de algunas posibles deficiencias técnicas es la voluntad firme de los "Cletos" de hacer teatro, de...

Frischmann, Donald H.

1983-10-01

264

EXCEPTIONAL SHEAVES ON DEL PEZZO SURFACES  

Microsoft Academic Search

In the present paper exceptional sheaves on del Pezzo surfaces are studied, and a description of rigid bundles on these surfaces is given. It is proved that each exceptional sheaf can be included in a complete exceptional collection. Furthermore, it is shown that all such collections can be obtained from each other by means of a sequence of standard operations

S. A. Kuleshov; D. O. Orlov

1995-01-01

265

PASO DEL NORTE SUMMER OZONE STUDY  

EPA Science Inventory

The Paso del Norte Summer Ozone Study was designed to evaluate potential control strategies for their efficacy in reducing ozone and carbon monoxide concentrations in the El Paso-Ciudad Juarez-Sunland Park international airshed of Texas, New Mexico, and Chihuahua. A field study ...

266

Sebastin Nieto Parra* ESTABILIDAD DEL SISTEMA  

E-print Network

Sebastián Nieto Parra* ESTABILIDAD DEL SISTEMA FINANCIERO Y REGULACI�N DE CAPITAL: EL CASO DE LOS financieros que pueden subsanar la fragilidad de los sistemas financieros y favorecer así la estabilidad de éstos. Palabras clave: sistema financiero internacional, instituciones financieras y crediticias, crisis

Paris-Sud XI, Université de

267

El teatro argentino del año 2000 y el teatro del futuro  

E-print Network

concepto deconstructivo, con su manejo de la contaminación textual, señaló el advenimiento del intertexto posmoderno en nuestro teatro. Las nociones que Jencks (97) postula para la arquitectura posmoderna pueden emplearse para acercarse al teatro de... incluyen en esta tendencia.10 Ellos, junto a otros creadores, están protagonizando desde los primeros años de la presente década una "nueva entrada al mundo" del teatro argentino. En un ambiente limitado durante mucho tiempo a "vivir con lo nuestro...

Pellettieri, Osvaldo

2000-10-01

268

Usos del sòl i tendències de transformació a la comarca del Baix Llobregat  

Microsoft Academic Search

A partir de les dades sobre sol urbà i sol urbanitzable programat, per usos, als municipis del Baix Llobregat, s'analitzen la realitat i les potencialitats en l'ocupació del sol a la comarca. Tot seguit es passa a descriure les principals tendències de transformació en aquest camp per a un futur proper, que s'associen, fonamentalment, als grans projectes de creació d'infraestructures

Javier Sáez

2008-01-01

269

Estudio para la prevención del cáncer necesita voluntarias: El Estudio del Tamoxifeno y Raloxifeno (STAR) se realiza en Norteamérica  

Cancer.gov

El Estudio del Tamoxifeno y Raloxifeno (STAR, por sus siglas en inglés), uno de los estudios más importantes realizados para la prevención del cáncer del seno, está ahora reclutando voluntarias en más de 400 centros en los Estados Unidos, Puerto Rico y Canadá.

270

Ttol: CONCURS PER A LA RENOVACI DEL LOGOTIP DEL PROGRAMA DACCI TUTORIAL (P.A.T.) DE LA FACULTAT  

E-print Network

DE FILOSOFIA I LLETRES Categoria: CONVOCAT�RIES I CONCURSOS �rgan: Facultat de Filosofia i Lletres RENOVACI� DEL LOGOTIP DEL PROGRAMA D´ACCI� TUTORIAL (P.A.T.) DE LA FACULTAT DE FILOSOFIA I LLETRES CONCURSO de Filosofia i Lletres convoca aquest concurs que té per objecte l´actualització distintiva del

Escolano, Francisco

271

CRECIMIENTO Y SUPERVIVENCIA DE JUVENILES DE Argopecten purpuratus EN SISTEMAS DE FONDO Y SUSPENDIDO EN LA ZONA DE CASMA, PERÚ GROWTH AND SURVIVAL OF JUVENILES OF Argopecten purpuratus IN BOTTOM AND SUSPENDED CULTURES IN CASMA, PERU  

Microsoft Academic Search

individuos\\/m2. Cada 2 semanas se colectaron 20 individuos y se registro la altura (mm) y peso de partes blandas (gramos) y mensualmente el número de muertos. Adicionalmente se registró información sobre los costos de producción para comparar la rentabilidad en ambos sistemas. Al final del experimento las tallas y pesos en el cultivo suspendido fueron mayores que en fondo y

Juan Arturo; Alcázar Zamora; Jaime Mendo Aguilar

272

Aproximación al cálculo del crecimiento real de Colombia: aportes metodológicos para la inclusión en las cuentas nacionales de los impactos del  

Microsoft Academic Search

Resumen El sistema de contabilidad integrada considera el problema del agotamiento de los recursos naturales. En este trabajo se analiza la diferencia entre este sistema y el de cuentas nacionales utilizando datos del sector minero en Colombia para gas natural y carbón. Los resultados muestran que al incorporar los impactos del agotamiento del gas natural y del carbón el PIB

Michee Lachaud; Jorge Maldonado

2011-01-01

273

ZAP70 Expression Within del6q21, del11q13 and del17p13 Cytogenetic Subgroups of Iranian Patients with Chronic Lymphocytic Leukemia  

PubMed Central

Background: B-cell chronic lymphocytic leukemia (B-CLL) is the most common form of leukemia in adults. Some reports showed that expression of ZAP70 gene and chromosomal abnormality are two prognostic factors in management of B-CLL Objectives: In this study, we determined ZAP70 mRNA expression level in the del17p13, del6q21 and del11q13 subgroups of Iranian B-CLL patients to investigate prognostic value of ZAP70 expression. Patients and Methods: In this cross-sectional study, fluorescence in situ hybridization analysis was carried out on 66 Iranian B-CLL patients. Zap70 mRNA expression was evaluated by using Real Time RT-PCR. Results: Molecular analysis showed that ZAP70 expression increased 2.46 fold in the del11q13 subgroup, 2.87 fold in the del17p13 and 1.87 fold in the del6q21, compared to the 15 patients in the control group. Comparison of standard deviation and mean of the ZAP70 expression profile within the subgroups showed more variability among the cases of the del11q13 and del17p13 versus tight clustering for the del6q21. Therefore, there is a relation between del6q21 aberrations; which has good prognosis with normal levels of ZAP70 expression. Conclusions: The results of ANOVA test showed that ZAP70 expression gene was significantly increased in del17p13 and del11q13 subgroups compared to control group. Thus, ZAP70 may play an important role in the prognosis of B-CLL patients.

Jafari Ghahfarokhi, Hamideh; Ashoori, Saeede; Akbari, Mohamad Taghi; Lotfizadeh, Masoud; Karimi, Ali; Teimori, Hossein

2014-01-01

274

Adherencia del tratamiento antibiótico en los cuadros  

Microsoft Academic Search

OBJETIVO: Evaluar la adherencia del tratamiento antibiótico observada en pacientes con cuadros infecciosos no complicados y tratados con diversas pautas antibióticas.\\u000aDISEÑO: Estudio observacional y prospectivo desde 2003 hasta 2008. ÁMBITO DE ESTUDIO: Dos centros de atención primaria de Cataluña.\\u000aSUJETOS: Pacientes de 18 años o más con sospecha de infección de etiología bacteriana de faringe, tracto respiratorio inferior, tracto

Nuria Sierra Montalbán; Silvia Hernández Anadón; Carles Llor Vilà; Ana Moragas Moreno; Marta Hernández Anadón; Carolina Bayona Faro

2010-01-01

275

Premio Ollantay 1989 - Acta del jurado  

E-print Network

, personas e instituciones cuyas trayectorias, dedicadas al desarrollo del teatro a nivel continental, ameriten ser destacadas como ejemplo. El Jurado designado por el CELCIT para otorgar los Premios Ollantay correspondientes al año 1989, integrado por... Colombia 2. Grupo de Teatro al Teatro Imagen, de Chile 3. Institución de Apoyo al Teatro al Consejo Nacional de Ciencia y Tecnología, CONCYTEC, de Perú 4. Teatro Infantil al Grupo de Teatro de Muñecos "Quijotillo," de Cumaná, Venezuela 5. Publicación...

1990-04-01

276

III Festival del Siglo de Oro (Chamizal)  

E-print Network

y los Estados Unidos, administrado por el Servicio Nacional de Parques como homenaje a la buena voluntad interamericana. Cuenta con una amplia sala de teatro donde se realizan muchas funciones culturales bilingües. Allá se celebró del 7 al 18 de... Tirso de Molina. Los grupos 112 LATIN AMERICAN THEATRE REVIEW participantes fueron invitados desde México, Venezuela, y la región sureña de los Estados Unidos. Se dividieron en dos categorías, grupos académicos y de reper torio, y compitieron por...

Jaraba-Pardo, E.

1978-04-01

277

Morphology, geology and geochemistry of the "Salar del Gran Bajo del Gualicho" (Rio Negro, Argentina)  

USGS Publications Warehouse

A multidisciplinary study of the Gran Bajo del Gualicho area (Rio Negro - Argentina) was carried out; the aim was to delineate its geological and geomorphological evolution and to estabilish the genesis of salts filling the depression. Climatic conditions were analized first to individuate their role in the present morphogenetic processes; moreover the main morphological features of present landscape were examined as well as the stratigraphy of the outcropping formations, and of the Gran Bajo del Gualicho Formation in particular. Finally, a possible geomorphological evolution of the studied area was traced. Geophysical analyses allowed to estabilish that the paleosurface shaped on the crystalline basement is strongly uneven and shows evidence of the strong tectonic phases it underwent. The result of isotope analyses confirmed that the salt deposits on the Gran Bajo del Gualicho bottom were produced by fresh water evaporation, while strontium isotope ratio suggested that such waters were responsible for solubilization of more ancient evaporitic deposits.

Angelucci, A.; Barbieri, M.; Brodtkorb, A.; Ciccacci, S.; Civitelli, G.; De Barrio, R.; Di, Filippo M.; Fredi, P.; Friedman, I.; Lombardi, S.; Schalamuk, A.I.; Toro, B.

1996-01-01

278

Reavivando las Zonas Muertas de las Costas  

NSDL National Science Digital Library

The issue-focused, peer-reviewed article addresses how dead zones, or areas that cannot support life, are increasing along the coast due to: agricultural runoff and fertilizers industrial waste, and acid rain, which is produced by the burning of fossil fuels.

Robert Howarth (Cornell University; )

2000-09-01

279

SISTEMA PARA GESTIONAR LA ACTIVIDAD CIENTÍFICA DEL DEPARTAMENTO DE INFORMÁTICA DE LA UNIVERSIDAD DE GUANTÁNAMO  

Microsoft Academic Search

El sistema para gestionar la actividad científica del Departamento de Informática de la Universidad de Guantánamo surge debido a la necesidad de gestionar de manera más rápida, segura y eficaz los procesos que se desarrollan actualmente en dicho centro. Fue desarrollado utilizando los lenguajes PHP del lado del servidor con CodeIgniter como framework y JavaScript del lado del cliente. Se

Denis Boizan Romero

2012-01-01

280

Consejera de Administraciones Pblicas y Portavoz del Gobierno Direccin General de Modernizacin  

E-print Network

. En esta segunda vía se inscribe la iniciativa del Repositorio Institucional del Principado de su autoarchivo los resultados de la investigación en el Repositorio Institucional del Principado de, favoreciendo el aumento del impacto del trabajo desarrollado por los investigadores y las instituciones

281

Efecto del Programa de Entrenamiento “Manejo del Dolor” en la Documentación de Enfermería en el Expediente Electrónico  

PubMed Central

Resumen En el presente trabajo se muestra la importancia de entrenar al personal de enfermería para mejorar la documentación en el expediente electrónico. Se eligió el manejo del dolor por ser un área prioritaria; una alta proporción de pacientes en período post operatorio cursa con dolor, por lo tanto, la documentación debe ser útil para la toma de decisiones clínicas. Se implementó un programa de entrenamiento denominado “Manejo del Dolor” dirigido al personal de enfermería. Se utilizó la tecnología de la información como herramienta para fortalecer el conocimiento con base en la revisión sistemática de la literatura; el personal de enfermería participante seleccionó la mejor evidencia; posteriormente se trabajó en la transferencia de este conocimiento a la práctica a través del diseño de un protocolo para el manejo del dolor. Se concluye que el conocimiento del manejo del dolor es fundamental para que enfermería documente con mayor precisión sus intervenciones. PMID:24199106

Monsiváis, María Guadalupe Moreno; Guzmán, Ma. Guadalupe Interial; Flores, Paz Francisco Sauceda; Arreola, Leticia Vázquez

2012-01-01

282

An evening at "La Clinica del Pueblo".  

PubMed

This article describes a typical evening at the Clinica del Pueblo in the Hispanic neighborhood of Adams-Morgan in Washington, D.c. The Clinical del Pueblo began operating in 1983 in response to the urgen medical needs of Central American refugees arriving in the Washington D.c. area. The refugees bring with them severe trauma, fear, and health problems caused by the civil was and exacerbated by inadequate or non-existant health services. Approximately 80,000 Salvadoran refugees live in the area. They do not receive adequate health care for 3 reasons. 1) Because the US goverment is unwilling to recognize them as true refugees, they live with the constant threat of deportatin back to the violence from which they have fled. 2) Refugees lack the ability to pay for private care. 3) Langauage and culture create frightening barriers to health care for the refugees. For those who do seek care, these barriers can lead to the inadequate or incomplete diagnoses and poor compliance and follow-up. Plenty International and the Central American Refugee Center responded to these problems by organizing a free clinic to provide not only medical care but also a training course for volunteers. The director of the clinic organizes the course, the classes are taught by a variety of people including the clinic's volunteer physicians, nurses, and public health educators as well as graduates of previus training courses and people from the wider community. The services of the clinic reach only a small portion of the population in need. However, the fact that free medical services are now available to some Central American refugees make the Clinica del Pueblo an important program. PMID:12281149

Shefsky, M L

1986-01-01

283

RELACIÓN MÉDICO PACIENTE: DERECHOS DEL ADULTO MAYOR  

PubMed Central

Existen prejuicios en relación con la vejez, incluso entre los profesionales que se dedican a la gerontología. Uno común y peligroso es considerar que los viejos son todos enfermos o discapacitados. La relación médico-paciente es la piedra angular de la práctica y ética médicas. Para alcanzar el respeto por los adultos mayores es necesaria una medicina prudente, basada en una práctica en la cual la reflexión ética y clínica pueda contribuir. Esto último es posible si se hacen valer los derechos del adulto mayor, en particular como paciente para la toma de decisiones. PMID:20379380

Barrantes-Monge, Melba; Rodríguez, Eduardo; Lama, Alexis

2009-01-01

284

Manual del espectrógrafo multifunción de Bosque Alegre  

NASA Astrophysics Data System (ADS)

Este manual consta de 120 páginas y resume las características del Espectrógrafo Multifunción instalado en el telescopio de 1.54 m de la Estación Astrofísica de Bosque Alegre. En este trabajo se describen, además, las técnicas a emplear para su puesta a punto y la secuencia de operaciones para la obtención de datos en cada uno de los modos que ya se encuentran en funcionamiento. Parte de este trabajo se realizó con el apoyo de la Asociación Argentina de Astronomía, a través de becas otorgadas a R.D. y S.P..

Díaz, R.; Paolantonio, S.; Carranza, G.; Goldes, G.

285

EXPERIENCIAS EN LA ENSEÑANZA DEL COMERCIO ELECTRÓNICO EN LA UNIVERSIDAD DE PINAR DEL RÍO  

Microsoft Academic Search

El desarrollo del Comercio Electrónico es uno de los objetivos de la política de informatización de la sociedad cubana, y en este sentido se labora en la creación de infraestructuras y la capacitación de los recursos humanos necesarios. Las universidades cubanas ya incluyen en sus planes de estudio este tema, cuyo aprendizaje contribuye a formar profesionales de mayor calidad para

Lisbet Martínez Gil

2010-01-01

286

Scheda del programma definitivo ITPS 2013-2014-Prof.ssa Antonietta Lanza Obiettivo del corso  

E-print Network

specifiche in SILAD preparatorie alla prova di laboratorio. E' pianificata una prova in itinere a metà corso prova di laboratorio e una prova scritta. La prova di laboratorio (prova parziale in ESSE3) mira analisi molto limitata) mediante un programma in linguaggio Java. L'esito della prova di laboratorio è del

Malerba, Donato

287

Huave de San Mateo del Mar, Oaxaca (Huave of San Mateo del Mar, Oaxaca).  

ERIC Educational Resources Information Center

This document is one of 17 volumes on indigenous Mexican languages and is the result of a project undertaken by the Archivo de Lenguas Indigenas de Mexico. This volume contains information on Huave, an indigenous language of Mexico spoken in San Mateo del Mar, in the state of Oaxaca. The objective of collecting such a representative sampling of…

Mexico Coll. (Mexico City)

288

El crimen como oficio: una interpretación del aprendizaje del delito en Colombia  

Microsoft Academic Search

El objetivo de este trabajo es proponer un marco de análisis que permita entender el aprendizaje del delito en Colombia. El articulo supone que el delito puede ser entendido como un actividad que requiere cierta experticia. En esta medida, el crimen requiere una compleja y extensa preparación, lo cual va en contra de la creencia de que cualquier persona, en

Isaac De León Beltrán; Eduardo S. Albarán

2003-01-01

289

CARACTERÍSTICAS DEL DIRECTIVO RESPONSABLE DEL ÁREA INTERNACIONAL Y RESULTADO EXPORTADOR DE LAS EMPRESAS INDUSTRIALES  

Microsoft Academic Search

RESUMEN La creencia de que la intensidad exportadora de las empresas puede estar ocasionada por barreras internas ha generado un cuerpo de investigación sobre la influencia de las características de los directivos responsables del área internacional (DRAI) en el inicio de las operaciones de exportación, la adopción de un papel activo en la intensificación de las exportaciones o el logro

Del Río Araújo

2005-01-01

290

Análisis del dispositivo de balón coil para la oclusión del Ductus Arterioso Persistente  

Microsoft Academic Search

RESUMEN: El ductus arterioso persistente (PDA) es uno de los defectos cardiacos congénitos más comunes. Consiste en una comunicación vascular anormal durante la vida extrauterina, entre la aorta descendente y la arteria pulmonar izquierda. El PDA puede llevar al desarrollo de complicaciones importantes como hipertensión pulmonar, edema pulmonar y endocarditis bacteriana. Actualmente el manejo del PDA se hace por medio

A. C. Silva; J. C. Briceño; A. García

291

Evaluacin de Diseo 2009 del Programa I. DATOS DE IDENTIFICACIN DEL PROGRAMA  

E-print Network

Presupuesto B00 Instituto Politécnico Nacional, Yoloxóchitl Bustamante Díez , Directora General D00 Instituto este análisis puedan retroalimentar el diseño y la gestión del programa VII. Costo total de la evaluación externa, especificando la fuente de financiamiento. Costo total: $500,000 Fuente de financiamiento

292

EL PERRO DEL HORTELANO: DEFINIENDO EL ROL EMPRESARIAL DEL ESTADO EN LATINOAMÉRICA  

Microsoft Academic Search

Las fuentes de agua fresca son abundantes en el Perú, sin embargo los peruanos tienen el segundo nivel de acceso más bajo a agua potable y desagüe en Sudamérica. Sólo el 72 por ciento de los hogares tienen acceso a agua potable por cañería (pero no se atreven a tomarla del grifo) y sólo el 51 por ciento tiene acceso

Carlos Patrón

2006-01-01

293

EL PLURIVERSO DEL AGUA. DISCURSOS, IMAGINARIOS Y CONTRATOS EN EL CONFLICTO DEL AGUA  

Microsoft Academic Search

Un buen modo de abordar el conflicto del agua consiste en prestar atención al nivel de los discursos. De este modo se puede poner de manifiesto los modos tan distintos de experimentar e interpretar la realidad que tienen los actores que en tal conflicto inter- vienen. Ahora bien, como algunos discursos enunciados no tienen el suficiente poder retórico y político

J. Ángel B ERGUA

294

EFICIENCIA DEL USO DEL AGUA EN LA PRODUCCIÓN AGRICOLA EN GUATEMALA  

Microsoft Academic Search

Los estudios de ciclo de vida, hasta hoy en día, han tenido en cuenta principalmente, los flujos de energía y materiales, no existiendo acuerdo en como tratar el recurso agua, siendo éste uno de los factores que deberían considerarse, especialmente en los sistemas de producción agrícolas. El manejo del agua en agricultura, asociado a su escasez, es uno de los

Willian E. de León; Asunción Antón

295

Respuestas a las preguntas del ejercicio de ``La Expansi'on del Universo y la Ley de Hubble''  

E-print Network

Respuestas a las preguntas del ejercicio de ``La Expansi'on del Universo y la Ley de Hubble'' --La constante de Hubble, H, debe de salir alrededor de 70 km s \\Gamma1 Mpc \\Gamma1 . El tiempo transcurrido desde el inicio del Universo ser'a t = D=V . Pero por otra parte, la constante de Hubble es H = V=D, de

Rodriguez, Luis F.

296

CONVENIOS DE COLABORACIN, MARCO Y ESPECFICOS FIRMADOS DURANTE EL CURSO ENTIDAD OBJETO DEL CONVENIO  

E-print Network

y Política Internacional. S21 Conocimiento y Productividad, S.L. Desarrollar líneas de colaboración Vida Llevar a cabo un operativo médico en diversas zonas de República Dominicana. Escuela Internacional de España, consejo Superior de Cámaras Oficiales de Comercio, Industria y Navegación de España

Rey Juan Carlos, Universidad

297

Influence of capillary pressure on CO2 storage and monitoring Juan E. Santos, CONICET, Instituto del Gas y del Petroleo, Facultad Ingenieria, Universidad de Buenos Aires,  

E-print Network

del Gas y del Petr´oleo, Facultad Ingenier´ia, Universidad de Buenos Aires, Department of Mathematics´ias, Instituto del Gas y del Petr´oleo, Facultad Ingenier´ia, Universidad de Buenos Aires, Jos´e M. Carcione

Santos, Juan

298

Instantánea de los cánceres de cerebro y del sistema nervioso central  

Cancer.gov

Información sobre las tendencias de incidencia, mortalidad y financiamiento del NCI sobre los cánceres de cerebro y del sistema nervioso central; así como ejemplos de actividades del NCI y adelantos en la investigación de estos tipos de cáncer.

299

78 FR 74008 - Amendment of Class E Airspace; Del Rio, TX  

Federal Register 2010, 2011, 2012, 2013, 2014

...controlled airspace at Laughlin AFB, Del Rio, TX. Environmental Review The...extension. * * * * * ASW TX E3 Del Rio, TX [Amended] Del Rio, Laughlin AFB, TX (Lat. 29...Fort Worth, Texas, on November 25, 2013. David P. Medina,...

2013-12-10

300

La formación del Partido Conservador: la fusión conservadora  

Microsoft Academic Search

Aunque la Restauración, en cuanto a su historia política, es un período muy agraciado por lo que a atención historiográfica se refiere, todavía algunos aspectos del período están bajo el dominio de lugares comunes discutibles. Uno de ellos es la formación del Partido Conservador. En este artículo se sostiene que la fuerza formada por Antonio Cánovas, si bien hunde sus

Fidel Gómez Ochoa

2003-01-01

301

Vida Arti cial: Estudio y an alisis del programa SWARM  

E-print Network

Jim#19;enez Introducci#19;on En este libro se realiza un estudio, a nivel introductorio, del campo de descubrir aplicaciones en una rama fundamental del citado campo: la de los Mundos Arti#12;ciales. El texto, y que proporcionaron aut#19;enticos hitos en este campo. A continuaci#19;on, se presenta el programa

Jiménez, Mario de J. Pérez

302

Calidad del aire interior y salud en las viviendas  

E-print Network

Calidad del aire interior y salud en las viviendas temporales de FEMA A los residentes de los tráileres Los Centros para el Control y la Prevención de Enfermedades (CDC) responden a las preocupa ciones que usted pueda tener sobre la calidad del aire y el formaldehído en los tráileres de FEMA. Usted

303

Decoding F508del misfolding in cystic fibrosis.  

PubMed

The functional deficiency of the cystic fibrosis transmembrane conductance regulator (CFTR), a plasma membrane chloride channel, leads to the development of cystic fibrosis. The deletion of a phenylalanine at residue 508 (F508del) is the most common cause of CFTR misfolding leading to the disease. The F508del misfolding originates in the first nucleotide-binding domain (NBD1), which induces a global conformational change in CFTR through NBD1's interactions with other domains. Such global misfolding produces a mutant chloride channel that is impaired in exocytic trafficking, peripheral stability, and channel gating. The nature and atomic details of F508del misfolding have been subject to extensive research during the past decade. Current data support a central role for NBD1 in F508del misfolding and rescue. Many cis-acting NBD1 second-site mutations rescue F508del misfolding in the context of full-length CFTR. While some of these mutations appear to specifically counteract the F508del-induced misfolding, others release certain inherent conformational constraints of the human wild-type CFTR. Several small-molecule correctors were recently found to act on key interdomain interfaces of F508del CFTR. Potential rational approaches have been proposed in an attempt to develop highly effective small molecule modulators that improve the cell surface functional expression of F508del CFTR. PMID:24970227

Wang, Xiaodong Robert; Li, Chenglong

2014-01-01

304

María Asunción Requena: Éxito e historia del teatro  

E-print Network

brujos y del futuro puente a construir; de las mujeres casaderas y de aquellas cuyos maridos partieron a la Patagonia. También hay sahumerios, huso y lana. ( Las Ultimas Noticias. 29 de octubre, 1989, p. 32) En junio del 89, Eduardo Guerrero...

Villegas, Juan

1995-04-01

305

> IRD/J. Orempuller Recursos y pilotaje del instituto  

E-print Network

44 45 s s s > © IRD/J. Orempuller #12;Recursos y pilotaje del instituto s Los medios financieros 46 disfrutado del apoyo de una importante movili- zación de los recursos financieros y de los medios humanos su patrimonio inmobilia- rio e invirtiendo en equipos científicos. medios financieros E L PRESUPUESTO

306

UNIVERSIDAD NACIONAL AUTNOMA DE MXICO Datos del plan de estudio  

E-print Network

Taekwondo Dirigido a: Entrenadores de la DGADyR, Comunidad Universitaria y Público General Síntesis o descripción breve: El curso le permite al interesado explicar el desarrollo histórico del taekwondo tanto en su país de origen, como en México, aplicar las diferentes técnicas del taekwondo para establecer la

Islas, León

307

ON THE MOTIVE OF A QUOTIENT VARIETY SEBASTIAN DEL BA ~  

E-print Network

ON THE MOTIVE OF A QUOTIENT VARIETY SEBASTIAN DEL BA ~ NO ROLLIN AND VICENTE NAVARRO AZNAR En with the realization functors and Chow groups. Recently, in the case char k = 0, Guill'en and Navarro Aznar have given. DEL BA ~ NO ROLLIN AND V. NAVARRO AZNAR group, K 0 M k , these decompositions were considered by Denef

Politècnica de Catalunya, Universitat

308

Analisi termica per la valutazione del danno negli acciai  

Microsoft Academic Search

RIASSUNTO. Sulla base di una metodologia consolidata, proposta in (26), per la definizione dell'intera curva di fatica di acciai mediante analisi termografica viene indicata una procedura per la valutazione del danno. Partendo dall'osservazione di base che ogni componente caricato dinamicamente, al di sopra del proprio limite di fatica, mostra un aumento di temperatura tanto più alto quanto più alto è

Antonino Risitano; Giacomo Risitano

2010-01-01

309

Impacto de las regalías petroleras en el Departamento del Meta  

Microsoft Academic Search

El departamento del Meta extrae petróleo crudo desde el año 1976, ubicándose, en la actualidad, entre los tres mayores productores del país. En consecuencia, con la influencia de su producción y las regalías, que han elevado el PIB departamental y fortalecido sus finanzas públicas, deben garantizarse amplías oportunidades de inversión, tanto pública como privada. El objetivo de este estudio es,

Germán Humberto Hernández Leal

2004-01-01

310

Inversiones en servicios públicos y dinámica del espacio urbano  

Microsoft Academic Search

El estudio de los servicios públicos constituye un campo en el que pueden examinarse la forma como la población satisface sus necesidades, los problemas y conflictos que se generan en el modo de producción, distribución y consumo, la relación entre el rol del Estado y las inversiones privadas en la satisfacción de esas necesidades y la construcción del espacio urbano.

Silvia Beatriz Grippo; Stella Maris Visciarelli

2007-01-01

311

Pastoral del Nino: Bringing the Abundant Life to Paraguayan Children  

ERIC Educational Resources Information Center

Pastoral del Nino is transforming children's lives in rural Paraguay. Part of Pastoral Social (Catholic Social Services), Pastoral del Nino's primary focus is to bring "vida en abundancia" (the abundant life) to families by ensuring that mothers survive childbirth and children reach their first birthdays. In addition, the organization promotes…

Austin, Ann Berghout; Aquino, Cyle; Burro, Elizabeth

2007-01-01

312

El comercio internacional en Colombia: una perspectiva diferente del TLC  

Microsoft Academic Search

La nueva teoría del comercio internacional deja de lado las diferencias entre los países en cuanto a recursos y se enfoca en las decisiones de los empresarios para presentar una visión alternativa de las implicaciones de la firma del Tratado de libre Comercio. La nueva teoría pone énfasis en la heterogeneidad de las empresas, en la relevancia de la productividad

Jan Ter Wengel; Luz Karine Ardila; Beatriz Ferreira Villegas; Luís Miguel Suárez Cruz

2007-01-01

313

EL COMERCIO INTERNACIONAL DE MÉXICO: ANTES Y DESPUÉS DEL TLCAN  

Microsoft Academic Search

El TLCAN trajo a México un alto pero breve crecimiento económico en sus primeros años de aplicación. En el pasado la economía y el comercio internacional del país estaba cimentado sobre la venta del petróleo crudo, teniendo una estabilidad importante en él, hasta el declive de sus precio en 1986, hoy en día el TLCAN a provocado un incremento sorprendente

Juan Antonio Herrera Izaguirre; Luis Hernán Lope Díaz; Alma Janeth Badillo Santes; Ramiro Aurelio Escobedo Carreón

2012-01-01

314

Conceptos fundamentales del desarrollo de proveedores (Caso de negocios 13)  

Microsoft Academic Search

El desarrollo de proveedores es una actividad que enriquece la gestión de la cadena de suministro, dotándola de mayor valor a través del aporte mutuo entre empresas clientes y subcontratistas. Este aporte incluye nuevas tecnologías, know-how, herramientas de la calidad y organización del trabajo, además de negociaciones sobre la política de precios, entre otros temas. En este trabajo presentamos sus

Enrique Yacuzzi

2012-01-01

315

[Escribir texto] DOBLE GRADO INGENIERA INFORMTICA -INGENIERA DEL SOFTWARE  

E-print Network

Desarrollo de Aplicaciones Web AIII 006 EAS Evolución y Adaptación del Software AIII 006 IA Inteligencia[Escribir texto] DOBLE GRADO INGENIERÍA INFORMÁTICA - INGENIERÍA DEL SOFTWARE Coordinador Informática - Ingeniería de Software 1er Semestre (Aulario III - Aula 002) Claves y profesores Clave

Rey Juan Carlos, Universidad

316

Valoración Económica y Ambiental Aplicada a Casos del Manejo de la Calidad del Aire y Control de la Contaminación  

Microsoft Academic Search

Este documento fue comisionado por la Red de Medio Ambiente del Diálogo Regional de Política para la III Reunión Hemisférica celebrada los días 9 y 10 de marzo de 2004. Durante las últimas décadas se han establecido derechos y obligaciones ciudadanas; se han definido las funciones del Estado y de los organismos públicos responsables en materia ambiental; se han realizado

Luis A. Cifuentes; Luis Rizzi; Héctor Jorquera; Javier Vergara

2004-01-01

317

El Instituto Nacional del Cáncer de EE. UU. y la República del Perú firman una Declaración de Intención  

Cancer.gov

El Instituto Nacional del Cáncer y la República del Perú firmaron una declaración de intención para compartir el interés en fomentar la investigación biomédica de oncología, basándose en la colaboración mutua de ambas entidades, así como el objetivo común de educar y capacitar la futura generación de científicos y clínicos en investigación oncológica.

318

IMPORTANCIA Y VIGENCIA DEL PENSAMIENTO DE EDGAR MORÍN EN LA COMPRENSIÓN DEL CONOCIMIENTO. UNA VISIÓN DESDE LA PSICOLOGÍA  

Microsoft Academic Search

El presente artículo pretende exponer los diferentes retos que presentan la educación y el aprendizaje del siglo XXI mediante la exposición de las particularidades que presenta el conocimiento adquirido por el hombre a través de su historia. Se basa fundamentalmente en algunos planteamientos ofrecidos por Edgar Morín en su libro “Los siete saberes necesarios para la educación del futuro” ,

Mildreth Larquin Castillo

2011-01-01

319

Notas para el estudio del cambio social a comienzos del quinto ciclo de Kondratiev. Un marco teórico  

Microsoft Academic Search

El alza de los precios del pétroleo acontecida en 1973 puso fin a la más reciente fase de expansión del excepcional ciclo de crecimiento iniciado después de la segunda Guerra Mundial. Luego de un periodo tan largo e impresionante de bonanza -la producción industrial de los países de la OCDE se quintuplicó por ejemplo entre 1947 y 1973- era natural

Mauricio Rojas

1991-01-01

320

La metodologia de la valoracion contingente en la evaluacion de proyectos ambientales : el caso del saneamiento del Rio Medellin  

Microsoft Academic Search

Como consecuencia del crecimiento de las ciudades, se hace cada vez más sentida la necesidad de desarrollar proyectos de carácter ambiental que subsanen el efecto negativo del urbanismo y las grandes concentraciones poblacionales. Tal es el caso de los rellenos sanitarios y sistemas de alcantarillado y tratamiento de aguas residuales, entre otros. Sin embargo, los problemas de contaminación y saneamiento,

Fredy Zuleta D

1994-01-01

321

La biomedicina del segle XXI: nous paradigmes i noves responsabilitats dels científics  

Microsoft Academic Search

Tal com s'inverteixen cada cop més recursos a tot el món en recerca biomèdica i en\\u000aciències de la salut, també evoluciona la tradicional confiança de la societat en el progrés\\u000acientífic. Creixen les demandes de participació, d'eficàcia, de més aplicabilitat i d'impacte\\u000asocial dels recursos públics dedicats a la recerca, mentre que la professió de científic encara\\u000aconserva una

Jordi Camí i Morell

2012-01-01

322

[La Medicina del Lavoro: 100 volumes].  

PubMed

With these pages La Medicina del Lavoro starts its 100th volume, so we have yet another historical occasion to celebrate the oldest occupational health journal in the world that is still publishing. Over the last few years we have had many occasions to celebrate, for example several anniversaries of the Journal (the 80th volume in 1989, 90 years in 1992, 100 years in 2001); the centenary of the foundation of the Clinica del Lavoro "Luigi Devoto" of Milan in 2001; the celebration of the 300 years' anniversary of the publication of De Morbis Artificum Diatriba by Bernardino Ramazzini, and we obviously hope to continue for many years to come in this positive outlook. One hundred volumes makes for a very large collection, with the highs and lows ofthe Journal's history (here we mean the variations in number of pages and physical size of the Journal). It is thanks to the Editors-in-chief(there have been very few so we can cite them all: Luigi Devoto, 1901-1936; Luigi Preti, 1936-1941; Enrico Vigliani, 1943-1992; e Vito Foà, 1992 to the present); the contributors who in various ways and with varying degrees of commitment but always with an exceptional personal participation, that it has been possible to reach 100 volumes, starting with C. Moreschi who, along with Luigi Devoto, was the first and sole editor at the Journal's foundation; up to the present extended and impressive editorial board; the printers (from the first. Tipografia Cooperativa, Via dei Molini in Pavia, to the latest: Casa Editrice Mattioli in Fidenza); the sponsors, including the most evident who, via advertising (rather limited as a matter offact), directly gave information about themselves, but also those who have often been or are behind the scenes, ensuring fundamental support which is not visible; content. articles, news, events, reports, ideas, opinions, photographs, tables, numbers... etc, which are really impossible to sum up. But the true collection which, for obvious reasons, cannot be individually named, consists of the people and the ideas that have enriched the history of the Journal in its over 100 years of existence. And the subscribers, above all, who by their almost anonymous presence have been the true guarantors of the Journal's ife. And of course the contributors who with their articles have consigned a part of their lives to history. Starting from 1925 we counted nearly 11.000, a really grand number. It would be wonderful if we could invite them all to a hypothetical (and impossible) grand convention to simply say "Thank you, your contributions will not be forgotten". There have been 100 volumes but in actual fact the Journal is more than 100 years old. It was founded in Pavia in 1901 as Il Lavoro-Rivista di fisiologia, clinica ed igiene del lavoro, and between 1901 and 1910 only three volumes were published, then, due to the difficulties during the First World War and the immediate post-war years, there were no issues in 1916, 1918 and 1919. Issues finally became regular in 1920 with volume 11; from that moment on not one issue was missed and the Journal even got through the Second World War without interruptions. In 1925, with volume 16, it took on the name that still distinguishes it to-day: La Medicina del Lavoro, "the official standard bearer of a work of enormous scientific, social and political content" as Luigi Devoto presented the event at the time. The first few years of the Journal were difficult ones (with only three volumes published in 10 years) to the effect that events such as the First International Congress on Occupational Diseases (Milano, 1906), the foundation of the International Commission for Occupational Health (1906), the First National Italian Congress on Occupational Diseases (Palermo, 1907), and above all the inauguration of the Clinica del Lavoro in Milano (20 March, 1910) are not reported in the Journal, which by 1911 had resumed publication but had moved to Milan. Many years have passed since those first three volumes and in the meantime we have moved on to another century and

Zocchetti, C

2009-01-01

323

ACTUALIDAD INTERNACIONAL DEL TRATAMIENTO MAGNÉTICO PARA EL CONTROL DE INCRUSTACIONES. REVISIÓN  

Microsoft Academic Search

Luego de una breve descripción del proceso de endurecimiento del agua, se brinda una amplia información actualizada sobre la tecnología del tratamiento magnético del agua como método anti- incrustante en sistemas de intercambio de calor. Se destaca las principales hipótesis o mecanismos que pudieran responder a los efectos industriales observados, así como algunos de los resultados experimentales de los investigadores

Rigoberto del Toro Rodríguez; Arístides Berenguer Maurant

324

Doctor Harold Varmus, director del NCI: Bienvenidos a Cancer.gov en español  

Cancer.gov

El director del NCI, doctor Harold Varmus, da la bienvenida a los visitantes al sitio web del NCI y habla sobre la complejidad del cáncer, así como de los avances alcanzados gracias a las nuevas herramientas y tecnologías para la investigación del cáncer.

325

S. ArgentiniS. Argentini ISAC CNR Area di Ricerca di Roma Tor Vergata,Via del Fosso del Cavaliere, 100 00133 Roma,ISAC CNR Area di Ricerca di Roma Tor Vergata,Via del Fosso del Cavaliere, 100 00133 Roma,  

E-print Network

S. ArgentiniS. Argentini 11 ISAC ­ CNR Area di Ricerca di Roma Tor Vergata,Via del Fosso del Cavaliere, 100 00133 Roma,ISAC ­ CNR Area di Ricerca di Roma Tor Vergata,Via del Fosso del Cavaliere, 100 00133 Roma, Italy,Italy, s.argentini@isac.cnr.its.argentini@isac.cnr.it SUMMARYSUMMARY The siteThe site

Ribes, Aurélien

326

UNIVERSIDAD NACIONAL AUTNOMA DE MXICO Datos del plan de estudio  

E-print Network

Futbol asociación Dirigido a: Entrenadores de la DGADyR, Comunidad Universitaria y Público General la técnica en el futbol para el grado ii III.- Técnica del portero aplicada al juego de conjunto a la

Islas, León

327

MEMORIA 2011 Torre de Control del antiguo aerdromo de Alicante  

E-print Network

MEMORIA 2011 Torre de Control del antiguo aeródromo de Alicante Nueva entrada a la UA enlace TRAM .........................................................................................................5 2.1 Resultados gestión de la calidad

Escolano, Francisco

328

Paso del Norte Watershed Council Coordinated Water Resources Database Project  

E-print Network

The Paso del Norte Watershed Council (PDNWC) is a quasi-governmental organization that serves in an advisory capacity to the New Mexico-Texas Water Commission regarding the selection, planning, and implementation of environmental enhancements...

Brown, Christopher; Sheng, Zhuping; Rich, Matt

329

La Revolucin del Shale Gas Profesor: Hugh Rudnick  

E-print Network

La Revolución del Shale Gas Mayo 2011 Profesor: Hugh Rudnick Profesional Externo: Verónica Cortés........................................................................................................................................ 6 ¿Qué es el Shale Gas...................................................................................................................................... 7 Shale Gas

Rudnick, Hugh

330

Trasmissione numerica: Compito del 10/02/2011 Esercizio 1  

E-print Network

' AWGN con densita' spettrale di potenza media bilatera N0/2, i segnali hanno uguale prob- abilita' un rumore AWGN con densita' spettrale di potenza media bilatera N0/2. L'energia del segnale trasmesso

Abrardo, Andrea

331

77 FR 47360 - Del Norte Resource Advisory Committee  

Federal Register 2010, 2011, 2012, 2013, 2014

...authorized under the Secure Rural Schools and Community Self-Determination...the Del Norte County Unified School District, Redwood Room...Six Rivers National Forest Supervisor's Office, 1330 Bayshore...Six Rivers National Forest Supervisor's Office, 1330...

2012-08-08

332

DEPARTAMENTO DE INGENIERIA INFORMATICA Normativas para el Programa Doctorado del  

E-print Network

DEPARTAMENTO DE INGENIERIA INFORMATICA Normativas para el Programa Doctorado del Departamento de Valiente, 11. Madrid, 28049. Teléfono: 914972230 #12;DEPARTAMENTO DE INGENIERIA INFORMATICA 4. Una vez

Autonoma de Madrid, Universidad

333

FRAGOMEN, DEL REY, BERNSEN & LOEWY, LLP US IMMIGRATION CLIENT ALERT  

E-print Network

FRAGOMEN, DEL REY, BERNSEN & LOEWY, LLP US IMMIGRATION CLIENT ALERT If you have any questions about to the United States. This Client Alert provides general guidance on procedures, including visa issuance at U

Scharer, John E.

334

Sapienza Universit di Roma Direttore del Dipartimento: Prof. Fabio Grasso  

E-print Network

posseduti dai candidati alla data della scadenza del termine utile per la presentazione delle domande di quale inviare ogni comunicazione, ivi comprese le convocazioni per il colloquio, senza che vi sia altro

Guidoni, Leonardo

335

Facultad de Estudios Superiores Acatln Datos del plan de estudio  

E-print Network

Dirigido a: Profesionales que deseen desarrollarse en las áreas de comercio internacional, gestión aduanera y negocios internacionales. Empresarios relacionados al comercio internacional. Personas interesadasFacultad de Estudios Superiores Acatlán Datos del plan de estudio Diplomado: Comercio exterior

Islas, León

336

Modular cell biology: retroactivity and insulation Domitilla Del Vecchio1,  

E-print Network

Modular cell biology: retroactivity and insulation Domitilla Del Vecchio1, *, Alexander J Ninfa2 a remarkable insulation property, due to the fast timescales of the phosphorylation and dephosphorylation: computational methods; metabolic and regulatory networks Keywords: feedback; insulation; modularity; singular

Sontag, Eduardo

337

Difusión de resultados iniciales del Estudio del Tamoxifeno y del Raloxifeno (STAR): el fármaco para el tratamiento de la osteoporosis, raloxifeno, es tan efectivo como el Tamoxifeno en la prevención de cáncer de seno invasor  

Cancer.gov

Los resultados iniciales del Estudio del Tamoxifeno y del Raloxifeno, STAR, demuestran que el fármaco raloxifeno, actualmente utilizado para prevenir y tratar la osteoporosis en mujeres posmenopáusicas, funciona tan bien como el tamoxifeno para reducir el riesgo de cáncer de seno entre las mujeres posmenopáusicas que tienen riesgo elevado de padecer la enfermedad. Preguntas y respuestas

338

Mecanica del Solido Deformable Presentacion de la asignatura  

E-print Network

Mec´anica del S´olido Deformable Presentaci´on de la asignatura Profesor Ignacio Romero E consulta (en la biblioteca): -- Introducci´on a la mec´anica de los s´olidos. Zubizarreta, V. y Ros, A asignatura 6 · La Mec´anica de S´olidos trata del estudio de modelos de comportamiento de s

Romero, Ignacio

339

La construccin del discurso en el siglo XIII  

E-print Network

« literarios », y, por otro, de las « creencias », más que « ideas », acerca de cómo evoluciona la sintaxis en « supraoracional », y cae bajo el análisis del discurso, más que de la sintaxis tradicional). 1.1. Las creencias suma, no usa la subordinación sintáctica, porque le bastan otros medios3, creencia nacida además del

Paris-Sud XI, Université de

340

Pedro, Juan y Diego: Obra fundacional del teatro contestario chileno  

E-print Network

paradigma en la adquisición de bienes de consumo y su sueño máximo era el vehículo propio. Para materializar este sueño los individuos debían ingresar al sistema de relaciones típicas del mundo impersonal del dinero, priorizando la competitividad y... Austin Mini-Toyota-Frigidaire... ¡Super compacta! ¡Una verdadera proeza de la tecnología nipona!" (102). Diego tenía una sociedad con otros ex-compañeros, todos desempleados ahora, que alimentaban este sueño que veía ya como imposible. El vehículo iba...

Lepeley, Oscar

2001-04-01

341

Aspectos clínicos de la biología molecular del cáncer de próstata  

Microsoft Academic Search

Resumen  La tecnología del ADN recombinante ha sido una herramienta invaluable para entender los mecanismos de carcinogénesis. Por\\u000a ejemplo, hemos podido conocer que en nuestro propio genoma existen genes con la capacidad de inducir transformación maligna\\u000a (oncogenes) on con la capacidad de bloquearla (genes supresores de tumores). Esta tecnología también nos ha permitido desarrollar\\u000a nuevas estrategias de diagnóstico y tratamiento del

Diana González-Espinosa; Miguel A. Jiménez Ríos; Andrés A. Gutiérrez-López

2002-01-01

342

La generación de 1924: El dilema del realismo  

E-print Network

, Celestino Gorostiza, repite sólo en parte esta trayectoria que estamos esbozando. Sus primeras obras reflejan intereses intelectuales típicos del momento. El nuevo paraíso (1930) recuerda los Autos de Villaurrutia en su visión de un Edén abstracto en el... dentro de las convenciones de su tipo: mucho movimiento, exageración, bailarinas en mallas, chanzas al arte abstracto, y moraleja final. La sátira halla sus blancos en diversos sectores de la vida publica y privada, tales como la corrupción del...

Dauster, Frank

1985-04-01

343

Del carnaval como 'metáfora' al teatro de carnaval  

E-print Network

la década de 1980) persigue contribuir al desarrollo de una manera más productiva de visualizar el teatro del carnaval, y en general, la práctica teatral en la actualidad. Actuación de la Anti-Murga BCG en el tablado "El Monumental del Control... funcionalizadas año tras año con ese fin. El escenario, el panel de fondo (comercial o alegórico), los asientos, la boletería, las paredes circundantes, se construyen de chapas, bloques y tablones. Cables y lamparitas colgantes, letreros, pintadas y graffitis...

Remedi, Gustavo

2001-04-01

344

Aportació a coneixement florístic del Moianès (Catalunya central)  

Microsoft Academic Search

Seguint en la línia d'ampliació del coneixement florístic de l'àrea del Moianès, presentem dades d'interès corològic de 46 tàxons. Es tracta bàsicament d'espècies d'ambients forestals i pradencs, bona part no citades d'aquest sector i algunes de molt rares o inexistents al territori ausosegàrric. Hi ha un primer grup d'espècies, que a les terres catalanes són bàsicament pirinenques [Linum viscosum L.,

Arnau Mercadé López

2007-01-01

345

Osservazioni sulla morfo-biologia del Pnigalio mediterraneus Ferr. & del. ( Hym. eulophidae )  

Microsoft Academic Search

\\u000a Résumé  L'Auteur confirme les observations deSilvestri concernant la polyphagie de l'espècePnigalio mediterraneus\\u000a Ferr. etDel. Le parasite attaque en Italie aussi bienLithocolletis millierella\\u000a Stgr. etL. blancardella\\u000a F., queDacus oleae\\u000a Gml. Il se développe aux dépens de mineuses de feuilles au printemps et attaque de préférence leDacus en été et en automne. L'auteur découvre ensuite que lePnigalio en question peut être un parasite

G. Viggiani

1963-01-01

346

La guerra del fin del mundo: historia e invencion en una novela historica  

E-print Network

, sino mediante una amplia plasmacion del ser, mediante la presentaci6n de c6mo las ideas, los sentimientos y los modos de actuar nacen de cate terreno historico" (Lukacs, 54). Este concepto de la autenticidad y la fidelidad historicas supone que... vision no menos real, pese a no ser "documentable" en el sentido estricto. La novels historica ha sufrido ataques de parte de los historiadores con respecto a los errores y el desconocimiento de la epoca que los novelistas pretendian recrear, mientras...

Loeffler, Lisa Bowe

1984-01-01

347

La judicializacin del caso de la pldora del da despus en Chile: las tensiones sobre el rol de la mujer y la cuestin tcnica1  

E-print Network

que serán supeditadas al contexto social en cual la política se inscribe. Introducción El Chile de la1 La judicialización del caso de la píldora del día después en Chile: las tensiones sobre el rol de en torno a la introducción de la píldora del día después en Chile. Esta discusión se posicionó en la

Paris-Sud XI, Université de

348

LOS NIVELES EMPÍRICO Y TEÓRICO DEL CONOCIMIENTO Y LA UTILIZACIÓN DEL MÉTODO HISTORICO LÓGICO EN LA FUNDAMENTACIÓN DEL APORTE TEORICO DE UNA TESIS DOCTORAL  

Microsoft Academic Search

En su función de tribunal y oponente a variadas tesis doctorales desarrolladas en los últimos tiempos se ha constatado, por los autores de este trabajo, algunos problemas en la aplicación de los métodos del pensamiento científico que dificultan a los aspirantes definir y defender los aportes fundamentales de sus investigaciones. A tono con estas situaciones a aparecido para los jóvenes

Miguel Erasmo; Zaldívar Carrillo; Samuel Oliveros Calderón

2008-01-01

349

Utilidad diagnóstica del Cuestionario TDAH y del Perfil de Atención para discriminar entre niños con tratorno por déficit de atención con hiperactividad, trastornos del aprendizaje y controles  

Microsoft Academic Search

Se analiza la convergencia entre la información recogida de padres y profesores, mediante escalas de valoración, y el diagnóstico clínico en una muestra de 126 niños: 42 con Trastorno por déficit de atención con hiperactividad (TDAH) tipo combinado, 21 con Trastornos del aprendizaje (TA) y 63 controles, con edades comprendidas entre los 4 y los 12 años. El grupo de

Juan Antonio Amador; Maria Forns; Joan Guàrdia Olmos; Maribel Peró

2005-01-01

350

Peat soil flows in Bahía del Buen Suceso, Tierra del Fuego (Argentina)  

NASA Astrophysics Data System (ADS)

On the southeastern edge of Tierra del Fuego, a mountainous area with a cold humid oceanic climate, peat soils cover not only flat areas but also steep hillslopes under an evergreen Nothofagus betuloides forest. Peat flows in the form of chutes are very frequent on these hillslopes. Some data were gathered on the field for 11 of these movements and from aerial photographs for 21 of them. The results suggest that peat soils become unstable when thickness exceeds a critical value which depends on the slope. This critical slope depends on the altitude and aspect regardless of soil thickness. A temporal analysis carried out by tree-ring counting demonstrated that the occurrence of these movements is not random though there are some periods of higher hazard, the probable triggering mechanisms being heavy snowfalls or earthquakes.

Gallart, Francesc; Clotet-Perarnau, Núria; Bianciotto, Oscar; Puigdefàbregas, Joan

1994-05-01

351

Mild phenotype in a patient with mosaic del(8p)/inv dup del(8p).  

PubMed

We report on a female with a mild phenotype who is mosaic for two cell lines with different structural abnormalities of 8p, both resulting in large genomic imbalances. Molecular cytogenetic and G-banded chromosome analyses demonstrated that one cell line has a large terminal 8p deletion, with a breakpoint in 8p21.2. The other cell line contains a derivative chromosome 8, known as an inv dup del(8p) in the literature. This female has developmental delay, but lacks congenital anomalies that are associated with either 8p abnormality in non-mosaic form. The attenuated phenotype in this individual may be due to compensation of one cell line for imbalances in the other cell line. PMID:20830805

Hand, Matthew; Gray, Carolyn; Glew, Gwen; Tsuchiya, Karen D

2010-11-01

352

PIANO DI RIQUALIFICAZIONE AMBIENTALE E PAESAGGISTICA DEL TERMOVALORIZZATORE DI DESIO TERMOVALORIZZATORE DI DESIO (MI) BRIANZA ENERGIA E AMBIENTE SPA  

E-print Network

PIANO DI RIQUALIFICAZIONE AMBIENTALE E PAESAGGISTICA DEL TERMOVALORIZZATORE DI DESIO Febbraio 2007 #12;PIANO DI RIQUALIFICAZIONE AMBIENTALE E PAESAGGISTICA DEL TERMOVALORIZZATORE DI DESIO Architecture Nature Development Febbraio 2007 #12;PIANO DI RIQUALIFICAZIONE AMBIENTALE E PAESAGGISTICA DEL

Columbia University

353

El Sexto Festival de Teatro Español del Siglo de Oro  

E-print Network

lindo don Diego, Compañía Pequeño Teatro de Madrid, España. La dama duende, Compañía Pequeño Teatro de Madrid, España. (Fuera de concurso) La cena del rey Baltasar, Escuela de Bellas Artes de la Universidad Autónoma de la ciudad de Chihuahua, Mé- 80... paso de las aceitunas, entremés en Casa con dos puertas, mala es de guardar, y Luis E. Julia por la música de la misma obra. Categoría B (No profesional) Mejor producción: , La cena del rey Baltasar, Escuela de Bellas Artes, Universidad Autónoma de...

Pé rez-Pisonero, Arturo

1981-04-01

354

Caracas: Escenario del mundo (V Festival Internacional de Teatro)  

E-print Network

, Perú y Venezuela); 1 de Estados Unidos; 2 de Japón, y 2 de Africa (Nigeria y Túnez). Además de los grupos de teatro propiamente dichos, y paralelamente a sus funciones en 11 salas del centro y la periferia de la capital, se organizaron una infinidad... teatristas y amigos del arte dramático a partir de la medianoche cuando ter minaba la última función en las salas de la ciudad. Era tal el número de gru pos teatrales y conjuntos musicales invitados a participar que, a más de las dos sesiones ordinarias de...

Má rceles Daconte, Eduardo

1981-10-01

355

Photometric study of the binary system NN Del  

NASA Astrophysics Data System (ADS)

We present the results of the differential V light curve analysis of NN Del. We show that NN Del is an EA eclipsing binary system with a period of 99.27 days and a highly eccentric orbit. Photometric solutions obtained using the Russell and the Wilson-Devinney models seem to indicate that both components are very similar in radii and luminosities (assuming a F5 spectral type). Constraints imposed on the V luminosity of the system by the HIPPARCOS data suggest that the components of the system could be subgiants instead of main sequence stars.

Gómez-Forrellad, J. M.; Sánchez-Bajo, F.; Corbera-Subirana, M.; GarcÍa-Melendo, E.; Vidal-Sainz, J.

356

El té y la prevención del cáncer: Solidez y límites de la evidencia científica  

Cancer.gov

Hoja informativa que resume los resultados de estudios realizados sobre el té y la prevención del cáncer. Incluye información sobre los ingredientes del té y las consideraciones de seguridad sobre el consumo de esta bebida.

357

Un análisis diferenciador del teatro de Virgilio Piñera: El teatro satírico burlesco y el teatro absurdista  

E-print Network

Jesús, de 1948, y Falsa alarma Pinera "se adelanta a algunos dramáticos europeos de su momento al utilizar recursos y temas del teatro del absurdo."4 Estas afirmaciones de los críticos parecen discrepar un tanto con las declaraciones que el mismo... realidad absurda que se dramatiza. Incluso en Electra Garrigó y Jesús, que son las únicas obras que acusan cierta preocupación metafísica, a la hora de categorizarias se hace difícil encuadrarlas dentro de la fisonomía del teatro del absurdo. En la...

Jerez Farrá n, Carlos

1989-04-01

358

La reescritura de Juan Moreira: La política del decorum en el teatro argentino  

E-print Network

periódicos y las revistas que publicaron historias como la de Juan Moreira, no sólo devaluaron los modelos que la "cultura letrada" había construido desde 1810 (mediante agrupaciones como la Sociedad del Buen Gusto del Teatro, fundada en 1811), sino que... exclusiva de los letrados. El control del libro no garantizaba el control del periódico y el periódico servía para que se introdujera un nuevo tipo de libro al gusto de un pueblo recién alfabetizado. El sistema literario promovido por la cultura letrada...

Podestá , Guido A.

1991-10-01

359

Prcticas de Evaluacin del Impacto Ambiental Revisin de Estudios de Impacto Ambiental  

E-print Network

Prácticas de Evaluación del Impacto Ambiental Revisión de Estudios de Impacto Ambiental Nombre y/salidas en términos de vertidos/recursos? C.- El Inventario Ambiental: - ¿Incluye todos los factores del? #12;Prácticas de Evaluación del Impacto Ambiental D.- La identificación de impactos: - ¿Qué método

Espigares, Tíscar

360

La Europa del Este en la historiografía española de las relaciones internacionales  

Microsoft Academic Search

La crisis del sistema del socialismo real y consiguiente caída de regímenes comunistas en Europa del Este, la desintegración de la Unión Soviética y la ruptura y guerra en la Federación Yugoslava han obligado a los historiadores y demás especialistas en estas cuestiones a revisar sus planteamientos sobre el origen y evolución de dicho sistema y a ampliar además los

Ricardo M. Martín de la Guardia; Guillermo Á. Pérez Sánchez

2001-01-01

361

Trayectorias tecnológicas de las máquinas térmicas e industrial del motor en España  

Microsoft Academic Search

En este trabajo se pretende analizar los diversos paradigmas y trayectorias tecnológicas relacionados con las máquinas térmicas a lo largo del siglo XIX y primeras décadas del XX para reflexionar sobre la dinámica evolutiva y lógica interna del propio proceso de innovación en el sector, sobre la participación española en el mismo y sobre el impacto específico de los avances

J. Patricio Saiz; R. Rubén Amengual

2005-01-01

362

UNIVERSIT DEGLI STUDI DI TORINO ISTRUZIONI PER LA COMPILAZIONE ON LINE DEL PIANO CARRIERA  

E-print Network

1 UNIVERSITÀ DEGLI STUDI DI TORINO ISTRUZIONI PER LA COMPILAZIONE ON LINE DEL PIANO://www.unito.it Per accedere alla funzionalità di presentazione del piano carriera devi accedere con le credenziali://www.unito.it/unitoWAR/page/istituzionale/istruzioni/P35407898381252672659560. 2. Compilazione del Piano Carriera Effettuato il login accedi al menù Segreteria

Sproston, Jeremy

363

Ciclo de vida del VIH Enlace y fusin: El VIH empieza su ciclo de vida  

E-print Network

VIH debe también ligarse a las proteínas CCR5 ó CXCR4 (co- receptores) para entrar en la célula receptor CD4 glucoproteína del VIH envoltura del VIH CCR5 receptor o CXCR4 receptor Un servicio del

Levin, Judith G.

364

Análise de esteiras microbianas e cianobactérias da laguna Amarga, Parque Nacional de Torres del Paine, Chile  

Microsoft Academic Search

ANALYSIS OF MICROBIAL MATS AND CYANOBACTERIA FROM THE LAGUNA AMARGA, TORRES DEL PAINE NATIONAL PARK, CHILE. This study is based on cyanobacterial and sedimentary investigations of the microbial mats formed at Laguna Amarga, located at the southernmost part of South America, specifically in the Chilean Torres del Paine National Park. The Torres del Paine's natural and geological richness is composed

Loreine Hermida da Silva

365

P/P/P/P/20202020 D.R. n.D.R. n.D.R. n.D.R. n. n. 5024 del 1.08.2011n. 5024 del 1.08.2011n. 5024 del 1.08.2011n. 5024 del 1.08.2011  

E-print Network

1.08.2011n. 5024 del 1.08.2011 ClasseClasseClasseClasse LM-6 - Biologia Nome del corsoNome del corso/2010, art. 14) 12 Obiettivi formativi qualificanti della classe: LM-6 Biologia I laureati nei corsi di biologia di base e nei diversi settori della biologia applicata e un'elevata preparazione scientifica e

Malerba, Donato

366

EL COMERCIO ELECTRÓNICO Y EL FUTURO DEL CANAL DE DISTRIBUCIÓN TURÍSTICO  

Microsoft Academic Search

RESUMEN Dentro de las implicaciones que el desarrollo de las nuevas tecnologías pueden tener sobre la eco- nomía, merece especial importancia el impacto que Internet y el comercio electrónico tienen sobre la estructura del canal de distribución, a través del cual las empresas ponen sus productos y servi- cios a disposición del mercado. En lineas generales se prevé que el

Sellers Rubio; R. Azorín Escolano

2001-01-01

367

Se pone en marcha el Programa de Investigación Oncológica Comunitaria (NCORP) del NCI  

Cancer.gov

El Instituto Nacional del Cáncer (NCI) ha otorgado 53 subvenciones nuevas de 5 años a investigadores de todo el país para realizar estudios clínicos multicéntricos e investigaciones sobre la prestación de cuidados oncológicos en sus comunidades. Las subvenciones se están otorgando dentro del Programa de Investigación Oncológica Comunitaria (Community Oncology Research Program, NCORP) del NCI.

368

Spectral Characterization of Volcanic Earthquakes at Nevado del Ruiz Volcano Using  

E-print Network

Spectral Characterization of Volcanic Earthquakes at Nevado del Ruiz Volcano Using Spectral Band methods in a two-class classification problem of volcanic earthquakes recorded at Nevado del Ruiz Volcano, seismic-volcanic events, spectral analysis. 1 Introduction Nevado del Ruiz is an ice-capped volcano placed

Duin, Robert P.W.

369

Aportació al coneixement florístic de les Guilleries i del Collsacabra (Catalunya Oriental),II  

Microsoft Academic Search

Presentem noves dades corològiques per a la flora vascular dels massissos de les Guilleries i del Collsacabra. En total, tractem 25 tàxons que podem dividir en cinc grups: 1.- nous per a les Guilleries (Peucedanum officinale L., Senecio adonidifolius Loisel., etc.); 2.- nous pel Collsacabra (Carex liparocarpos Gaudin, Seseli tortuosum L., etc.); 3.- nous per un ampli sector del nord-est

Aaron Pérez-Haase; Efrem Batriu; Arnau Mercadé López

2008-01-01

370

Medidas no financieras del rendimiento en la empresa: fundamentos, métodos y una aplicación  

Microsoft Academic Search

Describimos y fundamentamos la tendencia creciente a utilizar medidas no financieras para la medición del rendimiento empresarial (business performance measurement), así como una axonomía de estas medidas y el impacto del movimiento de la calidad total en las prácticas de medición. Las medidas que presentamos se caracterizan por (1) medir la productividad y la calidad desde la perspectiva del cliente;

Enrique Yacuzzi

2006-01-01

371

INFLUENZA DEL VALOR MEDIO SUL DANNEGGIAMENTO A FATICA IN SOLLECITAZIONI RANDOM  

Microsoft Academic Search

Sommario La presente memoria affronta il problema della stima dell'effetto del valor medio dei cicli rainflow nel calcolo del danno in un processo random stazionario ) (t X mediante metodi in frequenza. Sono presentati due approcci di complessità crescente: nel primo, si valuta il solo effetto del valor medio complessivo c m della sollecitazione, mentre nel secondo si include anche

D. Benasciutti; R. Tovo

372

EVOLUCIÓN DEL SERVICIO DE ACUEDUCTO Y ALCANTARILLADO DURANTE LA ÚLTIMA DÉCADA  

Microsoft Academic Search

Este documento presenta un análisis de los efectos de las reformas introducidas por la Constitución de 1991 y por la Ley 142 de 1994 sobre el desempeño del sector de agua potable y saneamiento básico. Incluye una descripción de esas reformas y del actual marco institucional y regulatorio del sector. El documento analiza la evolución de las realidades institucionales y

Carolina Domínguez; Eduardo Uribe

2005-01-01

373

PERFIL SOCIOECONÓMICO DEL MUNICIPIO DE SAN ANTONIO NANAHUATIPAM EN EL ESTADO DE OAXACA 2008  

Microsoft Academic Search

La Universidad Autónoma “Benito Juárez” de Oaxaca, a través de la Agencia de Desarrollo ha establecido el vínculo institucional en diversas comunidades del estado, para conocer los problemas que se dan en cada una de ellas y que no permiten su desarrollo. Es importante mencionar que a pesar del avance tecnológico en todas las ciudades del mundo, en México y

Ana Luz Ramos Soto

2008-01-01

374

in collaborazione con: Sovraintendenza ai Beni Culturali del Comune di Roma  

E-print Network

in collaborazione con: Sovraintendenza ai Beni Culturali del Comune di Roma con il patrocinio di l'Università `La Sapienza' di Roma ed ha come obiettivo la formazione del lighting designer e del-Tokyo, Artemide-Dubai, Regent-Basilea, Studio Fabertechnica S.a.S-Roma, Studio Annunziata&Terzi-Roma, Studio GMS

Di Pillo, Gianni

375

DD. 81/2014 del 22/07/2014 (Bando RTD n. .2_2014)  

E-print Network

Consiglio di Dipartimento del 12/02/2014; Visto il parere Favorevole del Collegio dei Revisori reso in data-dottorato. I suddetti requisiti devono essere posseduti alla data della scadenza del termine utile per la personale al quale inviare ogni comunicazione, ivi comprese le convocazioni per il colloquio, senza che vi

Roma "La Sapienza", Università di

376

Conozca cuáles son las opciones de atención del cáncer en su comunidad  

Cancer.gov

Este artículo hace una presentación general de las funciones del programa de centros oncológicos designados por el NCI y del programa de investigación oncológica comunitaria del NCI en Estados Unidos, los cuales son una fuente importante de atención para pacientes con cáncer.

377

Lars Bording, Responsabile del centro Huntington Bomilj Tangkr, Danimarca  

E-print Network

· Lars Bording, Responsabile del centro Huntington Bomiljø Tangkær, Danimarca Social work caregiver. Ore 16.30: Conclusione Artistica "Hope"con Shel Shapiro Woody Guthrie, la malattia di Huntington, Università degli Studi La Sapienza, Roma Storia e morale di un esperimento naturale: la Còrea di Huntington e

De Cindio, Fiorella

378

Manuel Garca Snchez-Colomer -1 Evaluacin del impacto ambiental  

E-print Network

Manuel García Sánchez-Colomer - 1 Evaluación del impacto ambiental Temas 12 - 13 Tema 12 impacto ambiental Temas 12 - 13 REAL DECRETO LEGISLATIVO 1/2008 por el que se aprueba el texto refundido de la Ley de Evaluación de Impacto Ambiental de proyectos Artículo 7. Estudio de impacto ambiental

Espigares, Tíscar

379

Simulaci on del Experimento La Plataforma Solar de Almer a  

E-print Network

Simulaci#19;on del Experimento GRAAL: La Plataforma Solar de Almer#19;#16;a como telescopio de El experimento GRAAL 25 2.1 Principios de funcionamiento . . . . . . . . . . . . . . . . . . . 25 2 . . . . . . . . . . . . . . . . . . . . . . 26 i #12; ii #19; INDICE GENERAL 2.2.2 El campo de heli#19;ostatos CESA-1 . . . . . . . . . . . . 27

380

Simulaci on del Experimento La Plataforma Solar de Almer a  

E-print Network

as a non-imaging #20; Cerenkov telescope for -ray astronomy. A central tower solar plant, as the CESA-1Simulaci#19;on del Experimento GRAAL: La Plataforma Solar de Almer#19;#16;a como telescopio de project makes use of the existing CESA- 1 array of heliostats at the Plataforma Solar de Almer#19;#16;a

381

Jacopo del Sellaio, "The Adoration of the Magi."  

ERIC Educational Resources Information Center

Offers a full-color reproduction of Jacopo del Sellaio's painting, "The Adoration of the Magi," and a lesson plan for using it with children in grades four through six. The goal of the lesson is to familiarize students with the concept of symbolism and its use in early Christian art. (JDH)

Linerode, Darla

1986-01-01

382

How Can Psychology Help Artificial Intelligence Alvaro del Val  

E-print Network

of intelligence, perception, and agency, on their discipline. I'll focus on the impact of psychology on AI todayHow Can Psychology Help Artificial Intelligence Alvaro del Val Departamento de Ingenier'ia Inform This paper discusses the relationship between Artificial Intelligence (AI) and Psychology. As an AI

del Val, Alvaro

383

Analisis estatico de tensiones Mecanica del Solido Deformable: Practica 2  

E-print Network

An´alisis est´atico de tensiones Mec´anica del S´olido Deformable: Pr´actica 2 Profesor: Ignacio estime oportuno. Adem´as, se deber´a presentar el an´alisis de una pieza mec´anica distinta a las

Romero, Ignacio

384

EXPERIENCIAS EN LA EXPANSIÓN NACIONAL DEL PROYECTO CONEXIONES  

Microsoft Academic Search

RESUMEN - Esta ponencia recoge los resultados obtenidos con el desarrollo del proyecto Expansión Nacional Conexiones, entendida ésta desde el análisis de la instalación de los productos tecnológicos, los modelos y programas resultado d e la investigación con el proyecto Conexiones, en tres nodos regionales, su pertinencia y aceptación en otras regiones de Colombia y el diseño d e la

Claudia Maria Zea Restrepo; Maria del Rosario Atuesta; Lilia Nayibe; Gelvez Pinto

385

EX BECARIO DEL PUMC GANA PREMIO "GENARO ESTRADA 2012"  

E-print Network

vigilancia #12;del Estado mexicano a los ciudadanos alemanes durante la Segunda Guerra Mundial, 1939 -1946 México tenía con los países aliados de la Segunda Guerra Mundial y el proceso de las relaciones". En su investigación, aborda las políticas que implementó el gobierno mexicano en la Segunda Guerra

Arroyo Rodríguez, Víctor

386

FOTOPLETISMOGRAFÍA CON DIODOS LÁSER INFRARROJOS EN ÓRGANOS INTRAPERITONEALES DEL CERDO  

Microsoft Academic Search

1. Resumen. Entre las técnicas que se emplean para monitorizar órganos y tejidos se encuentran la fotopletismografía, la oximetría de pulso y la flujometría por efecto Doppler láser. Existen procesos que afectan a determinados órganos o territorios del organismo, sin repercusión significativa en el grado de oxigenación periférica, que no pueden ser monitorizados con los dispositivos disponibles actualmente. Resulta necesario

S. M. López Silva; J. P. Silveira Martín; L. Herrera; M. L. Dotor Castilla

387

Al convegno associata la rappresentazione teatrale del testo  

E-print Network

Roma. Alan Turing's legacy | L'eredità di Alan Turing Roma 12 e 13 Ottobre 2012 Accoglienza dei Numerico Giuseppe Longo h. 16.45-17.30 Alan M. Turing: dalla Macchina alla morfogenesi Marcello D nell'invenzione del computer Roberto Cordeschi e Guglielmo Tamburrini h. 12.15-13.00 Alan Turing e l

Di Pillo, Gianni

388

E-commerce, la otra cara del comercio latinoamericano  

Microsoft Academic Search

El siglo XXI ha marcado grandes cambios en la modalidad analítica de los paradigmas de las relaciones económicas y, específicamente, comerciales del sistema internacional. Actualmente, conceptos como globalización o interdependencia no se discuten en la cotidianeidad de los debates y análisis de las relaciones internacionales. Esta situación se agudiza con la utilización cada vez más frecuente de Internet como herramienta

Diego Maturi

389

COMERCIO ELECTRÓNICO EN UNA LOCALIDAD DEL NORTE DE MEXICO  

Microsoft Academic Search

¿Está desplazando el comercio electrónico al comercio minorista tradicional? La respuesta tiene relación con el país, región o localidad donde se lleve a cabo; la capacidad de acceso a la red; así como con prácticas culturales asociadas a la seguridad en el uso del dinero electrónico y la confianza en los procedimientos de entrega de la mercancía adquirida.

Carmen Bocanegra Gastelum; Miguel Angel Vázquez Ruiz

2008-01-01

390

Design, aerodynamics and autonomy of the DelFly.  

PubMed

One of the major challenges in robotics is to develop a fly-like robot that can autonomously fly around in unknown environments. In this paper, we discuss the current state of the DelFly project, in which we follow a top-down approach to ever smaller and more autonomous ornithopters. The presented findings concerning the design, aerodynamics and autonomy of the DelFly illustrate some of the properties of the top-down approach, which allows the identification and resolution of issues that also play a role at smaller scales. A parametric variation of the wing stiffener layout produced a 5% more power-efficient wing. An experimental aerodynamic investigation revealed that this could be associated with an improved stiffness of the wing, while further providing evidence of the vortex development during the flap cycle. The presented experiments resulted in an improvement in the generated lift, allowing the inclusion of a yaw rate gyro, pressure sensor and microcontroller onboard the DelFly. The autonomy of the DelFly is expanded by achieving (1) an improved turning logic to obtain better vision-based obstacle avoidance performance in environments with varying texture and (2) successful onboard height control based on the pressure sensor. PMID:22617112

de Croon, G C H E; Groen, M A; De Wagter, C; Remes, B; Ruijsink, R; van Oudheusden, B W

2012-06-01

391

Charge neutrality in heavily doped emitters Jesus A. del Alamo  

E-print Network

Charge neutrality in heavily doped emitters Jesus A. del Alamo Instituto de Energta Solar ETSI fields important enough to invalidate the charge neutrality assumption. Therefore he concludes- jority carrier concentration nIx) and the net concentration of donor atoms in the emitter Nd(x) = ND

del Alamo, Jesús A.

392

ESERCIZIO DI ASD DEL 11 MAGGIO 2009 Minimum Spanning Tree  

E-print Network

ESERCIZIO DI ASD DEL 11 MAGGIO 2009 Minimum Spanning Tree Siano T1 e T2 due minimum spanning tree la lista ordinata dei pesi di A `e uguale ad L1, allora A `e un minimum spanning tree di G condizioni presenti nella definizione di min- imum spanning tree. Per refutare l'affermazione occorre invece

Piazza, Carla

393

El origen político del déficit fiscal en Colombia  

Microsoft Academic Search

El presente artículo desarrolla la tesis que la Constitución de 1991 elevó el gasto público total a niveles no sostenibles generando serios problemas fiscales que no han podido ser corregidos en su raíz estructural. La gran limitante a esta corrección ha sido la insuficiencia de apoyo político para proteger la estabilidad macroeconómica del país y verla como un patrimonio político

Eduardo WIESNER DURÁN

2004-01-01

394

La política petrolera en el marco del desarrollo sostenible  

Microsoft Academic Search

El artículo señala como un modelo de desarrollo económico sostenible en el que se incorporen algunos elementos que replanteen los paradigmas económicos vigentes desde la revolución neoclásica de finales del siglo pasado puede ser de gran utilidad para orientar las políticas y acciones gubernamentales y empresariales hacia un uso adecuado de los recursos naturales, entre estos, el petróleo. Tales elementos

Luis Guillermo Posada L; Elkin Vargas Pimiento

1997-01-01

395

Dispense del corso di laboratorio di Parte I: Statistica  

E-print Network

Dispense del corso di laboratorio di fisica Parte I: Statistica M. Prevedelli, M. Ridolfi A.A. 2004­2005 #12;Indice Introduzione 2 1 Propagazione degli errori I 4 1.1 Tipi di errore . . . . . . . . . . . . . . . . . . . . 78 D Fit di tipo generale 81 E Tabelle 84 1 #12;Introduzione Il risultato di ogni misura sperimentale

Achilles, Rüdiger

396

Faculty Activity Analysis in the Universidad Tecnica Del Estado Campuses.  

ERIC Educational Resources Information Center

An analysis of academic activities of college faculty at the eight campuses of Chile's Universidad Tecnica del Estado was conducted. Activities were grouped into seven categories: direct teaching, indirect teaching, research, community services, faculty development, academic administration, and other activities. Following the narrative…

Karadima, Oscar

397

Experiencias en el uso del sistema de laboratorios virtuales  

Microsoft Academic Search

Resumen: en este artículo presentamos las experiencias obtenidas del desarrollo y uso de SimulNet, una plataforma telemática de laboratorios docentes sobre Internet. SimulNet proporciona un entorno para el aprendizaje práctico altamente interactivo y colaborativo, incluyendo herramientas de apoyo a las tareas de seguimiento por parte de los profesores. Los criterios y principales líneas de su diseño fueron presentados en Novática

SimulNet L. Anido; M. Llamas; M. J. Fernández

398

DETERMINANTES DEL ACCESO AL MICROCRÉDITO PARA EMPRENDEDORES BOLIVIANOS  

Microsoft Academic Search

El crédito es una de las principales necesidades de los agentes económicos que deciden emprender una actividad económica propia. En Bolivia gran parte del financiamiento dirigido al sector informal se canaliza a través de la industria microfinanciera, la cual está conformada por entidades de distinta naturalez a jurídica desde organizaciones no gubernamentales hasta entidades financieras especia lizadas en el rubro.

Oscar A. Díaz Quevedo; Analista Financiero

399

Historia del Tiempo Presente e Historia de las Relaciones Internacionales  

Microsoft Academic Search

Es la Historia del Presente una disciplina en tiempo de elaboración teórica. El rasgo específico de nuestro presente histórico bien pudiera la sociedad tecnológica en construcción. Puesto que la sociedad tecnológica nos introduce en un entorno desterritorializado con un protagonismo de la información sin precedentes en la historia, intuimos que nos adentramos en una sociedad internacional singular, propia exclusivamente de

Montserrat Huguet Santos

2001-01-01

400

Se lanza Red Nacional de Estudios Clínicos del NCI  

Cancer.gov

El Instituto Nacional del Cáncer (NCI) puso en marcha una nueva red de investigación de estudios clínicos con el objetivo de mejorar el tratamiento de más de 1,6 millones de estadounidenses que reciben un diagnóstico de cáncer cada año.

401

UNIVERSIDAD NACIONAL AUTNOMA DE MXICO Datos del plan de estudio  

E-print Network

Taekwondo Dirigido a: Entrenadores de la DGADyR, Comunidad Universitaria y Público General Síntesis o descripción breve: El curso contempla entre otros temas: una reseña histórica del Taekwondo, así como aspectos emprender una labor que ayude a mejorar la preparación de los entrenadores y a desarrollar un Taekwondo

Islas, León

402

SEBBM 153 | Septiembre 2007 La amenaza del creacionismo  

E-print Network

8 SEBBM 153 | Septiembre 2007 La amenaza del creacionismo para la enseñanza racional de la biología biólogos tomen consciencia de la existencia de una seria amenaza para su disciplina,E En la actualidad diferentes a la biología. Incluso aquellos que son conscientes de la amenaza creacionista para la enseñanza

403

78 FR 30268 - Del Norte County Resource Advisory Committee  

Federal Register 2010, 2011, 2012, 2013, 2014

...progress. Should the Secure Rural Schools Act be reauthorized, the purpose...the Del Norte County Unified School District, Redwood Room, 301...Six Rivers National Forest Supervisor's Office, 1330 Bayshore...progress. If the Secure Rural Schools Act is reauthorized, the...

2013-05-22

404

ECC. MO TRIBUNALE AMMINISTRATIVO REGIONALE DEL LAZIO sede di Roma  

E-print Network

Odontoiatria e protesi dentaria (LM-46) per l'A.A. 2013/2014 (bando rettorale n. 2131 del 24 giugno 2013 in Medicina e Chirurgia (LM-41) e Odontoiatria e protesi dentaria (LM-46) per l'A.A. 2013/2014. La ricorrente

Guidoni, Leonardo

405

7. Saturn Atmospheric Structure and Dynamics Anthony D. Del Genio  

E-print Network

7. Saturn Atmospheric Structure and Dynamics Anthony D. Del Genio NASA Goddard Institute for Space, AZ 85721 #12;2 Abstract Saturn inhabits a dynamical regime of rapidly rotating, internally heated outbreaks near 35°S associated with Saturn electrostatic discharges, and in sporadic giant equatorial storms

406

Seminari del Dottorato in Informatica Prof. Margaret-Anne Storey  

E-print Network

Seminari del Dottorato in Informatica Prof. Margaret-Anne Storey University of Victoria (Canada: firstly, in how software stakeholders co-develop and form communities of practice; secondly-Anne Storey is a Professor of Computer Science at the University of Victoria and a Canada Research Chair

Malerba, Donato

407

Ricerca & Selezione del Personale | Consulenza Aziendale PAGE PERSONNEL  

E-print Network

management. La specializzazione delle divisioni è uno dei punti di forza, infatti i consulenti Page PersonnelRicerca & Selezione del Personale | Consulenza Aziendale PAGE PERSONNEL CHI SIAMO Page Personnel networks; un colloquio conoscitivo con il consulente Page Personnel, un colloquio con il cliente e per

Schettini, Raimondo

408

Comercio internacional y competitividad en la sociedad del conocimiento  

Microsoft Academic Search

Este estudio parte del supuesto de que la relación entre crecimiento económico y tecnología cobró mayor importancia a lo largo de las últimas décadas, y de desatacar los factores tecnológicos como uno de los aspectos más importantes al momento de explicar los flujos de comercio internacional. De este modo, la idea rectora de este artículo es que el progreso técnico

Laura Avondet; Fernando Piñero

2007-01-01

409

Mercato volontario del Carbonio e settore agro-forestale: best  

E-print Network

6-11-2012 1 Mercato volontario del Carbonio e settore agro-forestale: best practices a livello internazionale Davide Pettenella Dipart. Territorio e Sistemi Agro-forestali Università di Padova Convegno "I crediti di Carbonio agro-forestali in Italia: accordi post-Kyoto" Roma, 6.11.2012 Contenuti A. Il contesto

Pettenella, Davide

410

Miami: Meca del exilio cubano y escenario medido aunque efervescente  

E-print Network

exiliados que viajan a la isla a visitar a sus familiares conocen de primera mano. Este sentido de la marginalidad, del exilio interno, lo explora Sarraín, de nuevo, en lo que ha sido posiblemente su montaje más brillante, Delirio habanero, de Pedro...

Rizk, Beatriz J.

2000-10-01

411

Determinacion de Caracteristicas Opticas del Telescopio OAN150  

NASA Astrophysics Data System (ADS)

En el Observatorio de Calar Alto, en Almería, España, está ubicado un telescopio de 15O-cms de diámetro -construído por REOSC- perteneciente al Observatorio Astronómico Nacional, con sede en Madrid, España. La infraestructura técnica del OAN ha sido tradicionalmente débil y actualmente se está haciendo un esfuerzo por fortalecerla. Existe una información muy limitada del telescopio en general; de su óptica en particular se conocían los valores de los parámetros principales pero sin saber si éstos corresponden a valores teóricos ó de construcción. Por ello se consideró necesario iniciar una investigación para conocer en detalle los valores reales de las componentes ópticas del telescopio, obteniéndose algunos resultados de interés. El primario del telescopio OANl5O es aproximadamente F/3 y el siste ma en su conjunto es F/8.2, con su sistema corrector de campo. En términos generales, la imagen es satisfactoria en todo el campo y, sin sistema corrector, la imagen axial también es buena. En un futuro muy cercano se piensa diseñar instrumentación adicional para este telescopio. Conocer con mayor precisión sus características puede ser de gran utilidad para tal fin, pues se efectúan los cálculos considerando conjuntamente al telescopio y al instrumento.

Galan, M. J.; Cobos, F. J.

1987-05-01

412

El uso del lenguaje en los diferentes canales de Internet  

E-print Network

gramatical, frecuencia de palabras Francisco Manuel Rangel Pardo Director de Investigación y Desarrollo análisis de información de la Web. Premio MAVIR 2007 al mejor trabajo de investigación en procesamiento de, estructurados o desestructurados como la Web. Organizador principal de la tarea Author Profiling del PAN 2013

Rosso, Paolo

413

Control del dolor: Apoyo para las personas con cáncer  

Cancer.gov

Contiene información sobre las medicinas contra el dolor para pacientes con cáncer, los planes para controlarlo, cómo hablar con su equipo de atención médica sobre el dolor que usted siente y qué hacer para controlar los efectos físicos y emocionales del mismo.

414

ESTADO DEL ARTE DE CREENCIAS Y ACTITUDES HACIA LAS MATEMÁTICAS  

Microsoft Academic Search

La enseñanza de las matemáticas es actualmente de gran interés para los actores responsables del acto educativo, ya que los propósitos se entienden diferente para alumnos y profesores. Tal situación ha llevado a los matemáticos educativos y otros investigadores a indagar sobre las creencias y actitudes de estudiantes y docentes de matemáticas y su influencia en el logro académico. Las

Genaro Hernández Salazar

2011-01-01

415

INSTRUCTIVO PARA LA RESERVA E INSCRIPCIN DE ESTUDIOS GENERALES DEL  

E-print Network

dieciocho (18) créditos de Estudios Generales en el Ciclo Básico (LLA-111, LLA-112, LLA-113 y CSA-211, CSA-212, CSA-213), podrán inscribir a partir del cuarto trimestre, en las fechas que al efecto se

Vásquez, Carlos

416

PREDICTORES DE ABANDONO DEPORTIVO EN LA PRÁCTICA DEPORTIVA DEL FÚTBOL EN EL C. D. VIRGEN DEL CAMINO  

Microsoft Academic Search

El objetivo de esta investigación es encontrar una serie de indicadores en los deportis- tas del Fútbol Base que nos pongan en alerta de que estamos ante un sujeto potencial- mente predispuesto a la retirada, pudiendo intervenir a tiempo y así evitar el cese de la práctica. Para ello la muestra de nuestro estudio estuvo compuesta por 110 jugado- res

Fernández Pérez; Salguero del Valle; Martínez García

417

Futuro de las telecomunicaciones en México ¿Cuál debe ser el rol del gobierno ante los nuevos escenarios del mercado?  

Microsoft Academic Search

El objetivo del presente artículo es analizar las decisiones de política pública que está llevando a cabo el gobierno de México para impulsar la competencia en el mercado de telecomunicaciones. Para ello, se identifica la forma en la que está organizado este sector y se utilizan herramientas provenientes de la teoría económica de redes para evaluar las acciones de este

Fernando G. Toriz Flores

2010-01-01

418

Desarrollo del sistema financiero y crecimiento económico.Una aproximación a partir del caso boliviano: 2000-2009  

Microsoft Academic Search

De acuerdo a la teoría económica y la literatura empírica, el sistema por su rol de intermediación financiera, cumple un importante papel en la promoción del crecimiento económico. Sin embargo, en el caso boliviano la evidencia empírica existente es limitada, por lo cual este trabajo tiene como propósito averiguar mediante la utilización de métodos estadísticos y modelos VAR la relación

Julio Humeréz Quiroz; Ernesto Yáñez Aguilar

2011-01-01

419

Estrategia innovadora enfocada en parejas del mismo sexo para disminuir la infección del VIH en hombres Latinos  

PubMed Central

Resumen El VIH es un problema de salud importante dentro de la comunidad latina de los Estados Unidos. Gracias a los esfuerzos de prevención, los niveles de contagio entre los latinos se han mantenido estables por más de una década. Sin embargo, esta población sigue siendo afectada a niveles muy altos, en particular entre hombres que tienen sexo con hombres (HSH), de origen latino y que hablan principalmente el idioma español. Existen varios factores que contribuyen a la transmisión del VIH entre esta población, como son: el uso de drogas; la violencia dentro de la pareja; la presencia de infecciones de transmisión sexual; relaciones sexuales sin protección, dentro y fuera de la pareja; el evadir la búsqueda de recursos (prueba y tratamiento adecuado) por temor a ser discriminado o por su estatus migratorio; la escasez de recursos económicos o estado de pobreza y los patrones relacionados a la migración. En particular, Investigaciones Epidemiológicas de Comportamientos han determinado: cómo algunas dinámicas en parejas están directamente asociadas a los comportamientos sexuales de riesgos. En consecuencia, es necesaria mayor investigación para identificar esas dinámicas, y a su vez, realizar intervenciones dirigidas a la reducción de conductas de riesgo enfocadas en parejas de hombres del mismo sexo. En este escrito, se describe la importancia del uso de las relaciones de pareja como estrategia en la reducción de la trasmisión del VIH/SIDA en HSH de origen latino y que hablan principalmente el idioma español en los Estados Unidos. PMID:25580466

Martinez, Omar; Wu, Elwin; Sandfort, Theo; Shultz, Andrew Z.; Capote, Jonathan; Chávez, Silvia; Moya, Eva; Dodge, Brian; Morales, Gabriel; Porras, Antonio; Ovejero, Hugo

2014-01-01

420

CICLOS DE LA PRODUCCIÓN INDUSTRIAL EN COLOMBIA: EXTRACCIÓN DEL CICLO DEL SECTOR Y DE SUS RAMAS DE ACTIVIDAD  

Microsoft Academic Search

En este documento empleamos el filtro de Butterworth para analizar la producción industrial total y por ramas de actividad mediante la extracción de señales en las frecuencias bajas y altas. En las frecuencias bajas la tendencia de la producción al interior del sector exhibe una dinámica que difiere fuertemente entre actividades. En las frecuencias altas, la mayoría de las ramas

Constanza Martínez; Diana Mesa Téllez

2009-01-01

421

BOE nm. 67 Sbado 19 marzo 2005 9643 aspectos no regulados por este, la Orden del Ministerio del  

E-print Network

beneficiarios. El Ministro del Interior, a propuesta de la Dirección General de Protección Civil y Emergencias estudios extranjeros de educación superior. Mediante el Real Decreto 285/2004, de 20 de febrero, se ha extranjeros de educación superior, de conformidad con las previsiones contenidas en el artículo 36 de la Ley

Geffner, Hector

422

Incidencia de la calidad del suelo en los beneficios de los agricultores: caso del café, municipio La Vega  

Microsoft Academic Search

La fertilización que realizan los agricultores se hace con el objetivo de mejorar la rentabilidad de un cultivo, a través del aumento en la productividad, sin embargo, si no se tiene un manejo efectivo de la disponibilidad de nutrientes en el suelo, estas prácticas son ineficientes tanto social como privadamente. Socialmente por los costos medio ambientales generados a través de

Medina Carranco Nancy

1997-01-01

423

Esercitazione del 21 marzo 2003 Progetto del sistema di controllo di vibrazione per la sospensione di un'automobile  

E-print Network

di un'automobile (sospensione attiva) Il sistema raffigurato rappresenta lo schema semplificato pneumatico-ammortizzatore-telaio di un'automobile. Il sistema è caratterizzato dalla massa equivalente M dell'automobile esercitare sulla ruota e sul telaio dell'automobile e come azione disturbante d il profilo dell'asperità del

Monaco, Salvatore

424

Esercitazione del 7 marzo 2003 Progetto del sistema di controllo di vibrazione per la sospensione di un'automobile  

E-print Network

di un'automobile (sospensione attiva) Il sistema raffigurato rappresenta lo schema semplificato pneumatico-ammortizzatore-telaio di un'automobile. Il sistema è caratterizzato dalla massa equivalente M dell'automobile esercitare sulla ruota e sul telaio dell'automobile e come azione disturbante d il profilo dell'asperità del

Monaco, Salvatore

425

Esercitazione del 14 febbraio 2003 Progetto del sistema di controllo di vibrazione per la sospensione di un'automobile  

E-print Network

sospensione di un'automobile (sospensione attiva) Il sistema raffigurato rappresenta lo schema semplificato pneumatico-ammortizzatore-telaio di un'automobile. Il sistema è caratterizzato dalla massa equivalente M dell'automobile esercitare sulla ruota e sul telaio dell'automobile e come azione disturbante d il profilo dell'asperità del

Monaco, Salvatore

426

Esercitazione del 28 febbraio 2003 Progetto del sistema di controllo di vibrazione per la sospensione di un'automobile  

E-print Network

sospensione di un'automobile (sospensione attiva) Il sistema raffigurato rappresenta lo schema semplificato pneumatico-ammortizzatore-telaio di un'automobile. Il sistema è caratterizzato dalla massa equivalente M dell'automobile esercitare sulla ruota e sul telaio dell'automobile e come azione disturbante d il profilo dell'asperità del

Monaco, Salvatore

427

Historia del Banco de la República en Cali, y el establecimiento de los principales pilares bancarios en la ciudad a finales del siglo XIX e inicios del siglo XX  

Microsoft Academic Search

Dada la escasez de literatura sobre historia de las primeras entidades financieras que se establecieron en Cali a finales del siglo XIX e inicios del XX, este trabajo tuvo como fin, revelar, además de la historia, el papel que desempeñaron dichas instituciones como medio crediticio para financiar obras transcendentales para el desarrollo comercial, industrial y social de Cali, como lo

Jaime Andrés Collazos Rodríguez; Arley Barandica Villegas

2006-01-01

428

Analisis del contenido curricular de los Documentos Normativos del Programa de Ciencias en el area de biologia para la escuela superior del sistema de educacion publica de Puerto Rico: 1993-2012  

NASA Astrophysics Data System (ADS)

Esta investigacion de naturaleza cualitativa se ocupo de realizar un analisis de contenido documental de los Documentos Normativos del Programa de Ciencias en el area de biologia de la escuela superior del sistema de educacion publica de Puerto Rico del periodo 1993-2012. Los documentos analizados fueron: Guia Curricular, 1995; Marco Curricular, 2003; Estandares de Excelencia, 1996, 2000 y Estandares de Contenido y Expectativas de Grado, 2007. Se indago si hubo cambios en significados en los Componentes Estructurales: Naturaleza de la ciencia, Paradigmas para la ensenanza de la ciencia, Funcion del curriculo formal, Mision de la ensenanza de la ciencia; Contenidos, destrezas y competencias, Estrategias de ensenanza y Evaluacion/Assessment del aprendizaje. El analisis sugiere que no hubo cambios sustanciales en los significados de los Componentes Estructurales. Los documentos estudiados muestran mayormente caracteristicas similares, aunque los documentos mas recientes eran mas descriptivos, explicativos y especificos.

Davila Montanez, Melissa

429

The section of the Barranco del Gredero (Caravaca, SE Spain): a crucial section for the Cretaceous/Tertiary boundary impact  

E-print Network

in the future. Keywords: Caravaca, Spain, K/T boundary, extinction, impact. Resumen La sección del Barranco del/Tertiary boundary impact extinction hypothesis La sección del Barranco del Gredero (Caravaca, sureste de España exposed Cretaceous Tertiary (K/T) boundary sections in the world. Therefore, the Gredero section has

Smit, Jan

430

J. Field Ornithol. 73(1):8285, 2002 Locale-specific sugar packet opening by Lesser Antillean  

E-print Network

conducta. Las aves de la zona del hotel fueron las u´nicas que abrieron los paquetes y se alimentaron del azu´car, lo que sugiere que el patro´n de conducta es especi´fico de la zona. Key words: behavioral

Lefebvre, Louis

431

Optimización de herramientas multiobjetivo para la toma de decisiones de inversión en sistemas aislados sostenibles de energía  

Microsoft Academic Search

El problema multiobjetivo que nos ocupa en esta investigación es el de la provisión de energía eléctrica a una localidad perteneciente a zonas aisladas o que estén alejadas del sistema que interconecta a una región o un país, en Colombia se denominan zonas no interconectadas (ZNI). Las cuales, aunque representan 4,11% de la población nacional, abarcan cerca del 66% de

David Tobón Orozco; Sergio Agudelo Flórez

432

Deglacial palaeoclimate at Puerto del Hambre, subantarctic Patagonia, Chile  

Microsoft Academic Search

The primary objective of this study is to further substantiate multistep climatic forcing of late-glacial vegetation in southern South America. A secondary objective is to establish the age of deglaciation in Estrecho de Magallanes-Bahía Inútil. Pollen assemblages at 2-cm intervals in a core of the mire at Puerto del Hambre (53°3621S, 70°5553W) provide the basis for reconstructing the vegetation and

Calvin J. Heusser; Linda E. Heusser; Thomas V. Lowell; Andrés Moreira M; Simón Moreira M

2000-01-01

433

DISCURS DEL RECTOR DE LA UPF, JOSEP JOAN MORESO,  

E-print Network

potser és un bon moment per #12;2 considerar, com ho han fet destacats membres del Parlament, que en afrontar amb garanties d'èxit aquesta etapa. L'inici d'un nou curs acadèmic acostuma a ser un bon moment humans. �s allò que fa possible la nostra manera de dominar la natura, de fer-la nostra. Ara parlem

Geffner, Hector

434

2. COURSE OF THE LATERAL THROUGH DEL NORTHWEST MAR PARK. ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

2. COURSE OF THE LATERAL THROUGH DEL NORTHWEST MAR PARK. - Highline Canal, Sand Creek Lateral, Beginning at intersection of Peoria Street & Highline Canal in Arapahoe County (City of Aurora), Sand Creek lateral Extends 15 miles Northerly through Araphoe County, City & County of Denver, & Adams County to its end point, approximately 1/4 mile Southest of intersectioin of D Street & Ninth Avenue in Adams County (Rocky Mountain Arsenal, Commerce City Vicinity), Commerce City, Adams County, CO

435

3. 1939 DROP STRUCTURE IN DEL MAR PARK SURMOUNTED BY ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

3. 1939 DROP STRUCTURE IN DEL MAR PARK SURMOUNTED BY RECENT PEDESTRIAN BRIDGE. - Highline Canal, Sand Creek Lateral, Beginning at intersection of Peoria Street & Highline Canal in Arapahoe County (City of Aurora), Sand Creek lateral Extends 15 miles Northerly through Araphoe County, City & County of Denver, & Adams County to its end point, approximately 1/4 mile Southest of intersectioin of D Street & Ninth Avenue in Adams County (Rocky Mountain Arsenal, Commerce City Vicinity), Commerce City, Adams County, CO

436

Le Thorium Molten Salt Reactor : Au del du MSBR  

E-print Network

Le Thorium Molten Salt Reactor : Au delà du MSBR L. Mathieu, D. Heuer, A. Billebaud, R. Brissot, C réflexion est menée afin de trou- ver des solutions et ainsi d'aboutir au concept du Thorium Mol- ten Salt optimale du minerai d'uranium ou de thorium, une conception résistante à la prolifération, une meilleur

Paris-Sud XI, Université de

437

Inform`atica Aplicada a la Traduccio: normes del curs  

E-print Network

les preguntes que feu en l'aula, en el laboratori, en el Campus Virtual, o quan veniu al despatx estan- par`a durant el primer quadrimestre del curs. Hi haur`a dos tipus de sessions: les sessions d'aula i les sessions de laboratori. L'assignatura consta de 4,5 cr`edits; en total hi haur`a 13 sessions d'aula

Forcada, Mikel L.

438

Solar adaptive optics at the Observatorio del Teide, Tenerife  

NASA Astrophysics Data System (ADS)

Observing the Sun with high angular resolution is difficult because the turbulence in the atmosphere is strongest during day time. In this paper we describe the principles of solar adaptive optics exemplified by the two German solar telescopes VTT and GREGOR at the Observatorio del Teide. With theses systems we obtain near diffraction limited images of the Sun. Ways to overcome the limits of conventional AO by applying multiconjugate adaptive optics (MCAO) are shown.

Soltau, Dirk; Berkefeld, Thomas; Schmidt, Dirk; von der Lühe, Oskar

2013-10-01

439

The San Jose Del Monte Water Supply Expansion Project  

Microsoft Academic Search

This project is an expansion of the existing water supply system in San Jose Del Monte and is being proposed for funding by the Local Water Utilities Administration (LWUA), a government-owned quasi-corporate entity that provides institutional and financial support to the municipal water districts in the country. The project aims to increase the district’s system operational storage in order to

Glenn Jenkins; BAHER EL-HIFNAWI

1999-01-01

440

La computacin y sus versiones : El Debate del Software  

E-print Network

La computación y sus versiones : El Debate del Software Software Libre vs. Software Privativo Pablo controladas por el código (el software). Pero ... ¿Quién controla el código? ¿De quién recibe órdenes tu computadora? ¿Tenemos derecho a saber exactamente qué hace nuestra computadora? #12;¿Qué es el Software Libre

De Nápoli, Pablo Luis

441

MATH 22AL Fall 2012 Dr. Dad-del  

E-print Network

MATH 22AL Fall 2012 Dr. Dad-del Important Information about MAT22A and MAT22AL MATH 22AL is an on line computer lab for MATH 22AL. This course uses MATLAB to reinforce the concepts learned in MATH22A. All MAT 22A students are required to take 22AL, unless they have taken Eng 6 or have a good knowledge

Goldwyn, Eli

442

Efectos del control cambiario en la actividad turística. Caso Venezuela  

Microsoft Academic Search

RESUMEN El 2 de diciembre de 2002, las reservas internacionales de Venezuela ascendían a US$12.447 millones y el 31 de diciembre del mismo año cayeron a US$11.873 millones. En consecuencia, el Gobierno estableció un régimen de control cambiario y creó la Comisión de Administración de Divisas. En este artículo se estudian los efectos de esta medida en el sector turístico,

2007-01-01

443

Récord de longevidad del Correlimos Zarapitín (Calidris ferruginea)  

Microsoft Academic Search

En aquesta nota es descriu el control d'un territ bec-llarg disset anys després del seu anellament. L'ocell es va marcar com a jove el 5 de setembre de 1975 a Friesland (Holanda) i es va recapturar el 3 d'agost de 1992 al delta de l'Ebre, 6173 dies després de l'anellament. Fins ara la màxima longevitat demostrada per a aquesta espècie

Jordi Figuerola

1995-01-01

444

Panoràmica dels sistemes de gestió de biblioteques al segle XXI  

Microsoft Academic Search

En la darrera dècada s'han consolidat un conjunt de tendències en l'àmbit de la informàtica general que han afectat profundament les biblioteques. La popularització d'Internet, l'aparició de sistemes oberts i interoperables, la consolidació d'entorns gràfics i multimèdia o la implementació generalitzada de xarxes d'àrea local són algunes de les realitzacions del període. Tot plegat ha fet que les biblioteques hagin

Marina Salse i Rovira

2005-01-01

445

Descripción del coronógrafo a ser instalado en Argentina (MICA)  

NASA Astrophysics Data System (ADS)

El ``Coronógrafo de espejo para Argentina'' es un telescopio solar terrestre a ser colocado en el Observatorio Astronómico Félix Aguilar (El Leoncito), antes de finalizar 1996, como parte de un programa de ciencia bilateral entre Alemania y Argentina. Eclipses fotográficos de alta resolución han revelado que la corona solar es altamente estructurada y variable. De hecho, está contínuamente deformada y moldeada por los movimientos convectivos de los extremos de los arcos magnéticos en la fotosfera, estando, en muchas oportunidades, afectada por explosivas liberaciones de energía. MICA, en conjunción con otros telescopios solares espaciales y terrestres, tratará de contribuir al entendimiento de cuestiones fundamentales de la física solar. Entre ellas: cómo la corona está siendo calentada, dónde y cómo el viento solar es acelerado, qué causa los transitorios coronales, etc. Para ello investigará la distribución de los parámetros del plasma y su evolución con el tiempo, la estructura espacial de la corona en fina y gran escala, procesos que ocurren en los transitorios coronales y factores que los disparan, etc. Para responder a estas cuestiones MICA observará la atmósfera solar por sobre el limbo entre 1.1 y 2 radios solares aproximadamente, usando un nuevo tipo de sistema coronográfico que permite suprimir el brillo del disco solar suficientemente bien, tomando las imágenes con una cámara CCD de 1024x1024 pixels, codificada en 12 bits, pudiendo el mismo ser operado en forma remota. En la presente exposición describiremos las características del instrumento, cómo será controlado y qué esperamos observar basados en las imágenes obtenidas por los telescopios de similares características LASCO C1 a bordo del SOHO y PICO (ubicado en el Observatorio de Pic du Midi, Francia).

Stenborg, G.; Francile, C.; Schwenn, R.; Epple, A.; Rovira, M.

446

El Teatro Taller de Colombia: La resurrección del atavismo  

E-print Network

saben que esas profundidades anímicas existen; sólo algunos de ellos logran expresar luego coherentemente ese fondo en el mundo del conciente, por medio de leyes físicas o matemáticas, de intuiciones religiosas o de grandes obras de arte. ¿Cómo? Por... California los afirmó en su búsqueda; el teatro chicano trabajaba las creencias populares de grupos segregados en una amplia sociedad cosmopolita, era la afirmación de su propia identidad; ellos, que andaban en el extranjero, sin duda sintieron con fuerza...

Gonzá lez Cajiao, Fernando

1991-10-01

447

Modeling Visibility in the EL Paso del Norte Region  

NASA Astrophysics Data System (ADS)

Poor visibility is a subject of growing public concern throughout the U.S, and an active area of research. Its societal impacts in air quality, aviation transport and traffic are significant. Aerosols play a fundamental role in the attenuation of solar radiation, and also affect visibility. The scattering and extinction coefficients of aerosol particles in the Paso del Norte Region have been calculated using the T- matrix model in conjunction with a laser particle counter. Inter-comparison of the model's results of the scattering and absorption coefficients against the corresponding data from a Photoacustic Extinctiometer instrument (which measures in-situ absorption and scattering coefficients of aerosol particles) shows excellent agreement. In addition, the volume-weighted method is used to determine the composite index of refraction which is representative of the aerosols for the Paso del Norte Airshed to obtain information of the type of aerosol particles present in the Airshed. The Single Scattering Albedo has also been retrieved using our methodology to obtain further insight into the type of aerosols present on a given day. Finally, the Koschmieder equation has been used to calculate the visual range or visibility, and was correlated with the PM2.5 and PM10 particle concentration present in the Airshed. Our methodology will allow a better understanding of the size and type of aerosol particles that are most detrimental to the visibility for the Paso del Norte Region.

Fitzgerald, R. M.; Medina, R.; DuBois, D. W.; Novlan, D.

2013-12-01

448

Modeling visibility in the Paso del Norte (PDN) Region  

NASA Astrophysics Data System (ADS)

Poor visibility is a subject of growing public concern throughout the U.S, and an active area of research. Its societal impacts on air quality, aviation transport and traffic are significant. Aerosols play a fundamental role in the attenuation of solar radiation, and also affect visibility. The scattering and extinction coefficients of aerosol particles in the Paso del Norte Region have been calculated using the T- matrix model in conjunction with a laser particle counter. Inter-comparison of the model's results of the scattering and absorption coefficients against the corresponding data from a Photoacustic extinctiometer instrument (which measures in-situ absorption and scattering coefficients of aerosol particles) shows excellent agreement. In addition, the volume-weighted method is used to determine the composite index of refraction which is representative of the aerosols for the Paso del Norte Region to obtain information of the type of aerosol particles present in the Region. The Single Scattering Albedo has also been retrieved using this methodology to obtain further insight into the type of aerosols present on a given day. Finally, the Koschmieder equation has been used to calculate the visual range or visibility, and was correlated with the PM2.5 and PM10 particle concentration present in the Region. Our methodology will allow a better understanding of the size and type of aerosol particles that are most detrimental to the visibility for the Paso Del Norte Region.

Medina Calderon, Richard

449

D.R. n.5024 del 01.08.2011 ClasseClasseClasseClasse L-5 -Filosofia  

E-print Network

H/1 D.R. n.5024 del 01.08.2011 ClasseClasseClasseClasse L-5 - Filosofia Nome del corsoNome del corsoNome del corsoNome del corso Filosofia Nome ingleseNome ingleseNome ingleseNome inglese Philosophy della legge n. 240/2010, art. 14) 12 Obiettivi formativi qualificanti della classe: L-5 Filosofia I

Malerba, Donato

450

EMPLAZAMIENTO DE NIDOS DE ARDILLA ROJA Sciurus vulgaris EN MELOJARES Y SETOS ARBOLADOS DEL VALLE DEL RÍO TORÍO (LEÓN, NO DE ESPAÑA)  

Microsoft Academic Search

RESUMEN Se describe el emplazamiento de 49 nidos de ardilla roja Sciurus vulgaris en setos arbolados (n=28), plantaciones de chopos (n=14) y bordes de melojares (n=7) del valle del río Torío (León). Todos los nidos encontrados en melojares y plantaciones de chopos estaban instalados en melojos Quercus pyrenaica y chopos híbridos Populus x canadensis, respectivamente, debido al carácter prácticamente monoespecífico

A. HERNÁNDEZ

451

Nuevo sitio web en español del Instituto Nacional del Cáncer, (NCI, por sus siglas en inglés) Cancer.gov en español - Silvia Inéz Salazar - transcript  

Cancer.gov

Transmisiones de radio para promover Cancer.gov en espa%XF1ol | Nuevo sitio web en espa%XF1ol del Instituto Nacional del C%XE1ncer, (NCI, por sus siglas en ingl%XE9s) Cancer.gov en espa%XF1ol | Transcripci%XF3n Transmisiones de radio para promover

452

COMPOSICIÓN QUÍMICA DE LOS METABOLITOS SECUNDARIOS VOLÁTILES DE Pelargonium graveolens, EN FUNCIÓN DEL MÉTODO DE EXTRACCIÓN Y ÉPOCA DE RECOLECCIÓN DEL MATERIAL VEGETAL  

Microsoft Academic Search

RESUMEN En la presente investigación se estudió la composición química de los metabolitos secundarios volátiles aislados del geranio, Pelargonium graveolens, en diferentes épocas de recolección del material vegetal mediante dos técnicas de extracción: hidrodestilación asistida por la radiación de microondas (MWHD) y destilación - extracción con solvente simultánea (SDE). Las fracciones volátiles se analizaron por cromatografía de gases acoplada a

DEYNY LETICIA; MENDIVELSO PÉREZ; MARTHA CECILIA OLIVARES; Estudiante de Química

453

MIC 38/GA 841ADE 2456/S Rev. 10 (3-13) (INTERNET) Page 1 of 2 El Departamento del Desarrollo del Empleo (EDD) es un  

E-print Network

MIC 38/GA 841ADE 2456/S Rev. 10 (3-13) (INTERNET) Page 1 of 2 El Departamento del Desarrollo del Employment Development Department Los Beneficios para las Personas Que Buscan Empleo l Acceso por Internet a Internet. l Reduce la necesidad de solicitar servicios en persona. l Acceso equitativo a las personas que

454

The 2012 Reactivation of Nevado del Ruiz Volcano, Colombia  

NASA Astrophysics Data System (ADS)

Nevado Del Ruiz volcano is most known for its tragic November 13, 1985 explosive event, when a small eruption produced an enormous lahar that buried and destroyed the town of Armero in Tolima, causing an estimated 25,000 deaths. Similar but less deadly incidents occurred in 1595 and 1845, again where a small explosive eruption was followed by a large lahar. Other minor explosive events occurred in 1805, 1828-9, and 1989. The Armero tragedy was a major factor in the establishment of a volcano monitoring program in Colombia. The network monitoring Nevado del Ruiz volcano has dramatically improved since the 1985 eruption and now includes geodetic, geophysical, geochemical and visual monitoring. The activity of Nevado Del Ruiz between 1985 and 1991 saw significant increases in seismicity and significant gas emissions with the main eruptive events of November 13, 1985 and September 1st, 1989. The volcano became seismically active again in 1995 and 2002, whit an increase in seismicity, without any gas emission or eruption. In October 2010 the volcano entered in a new phase of unrest with increased seismicity (HB events), deformation and gas emissions, likely associated with a new magma intrusion. In February, 2012 the volcano had a new and significant increase in seismicity (VT-LP), followed in May and June 2012 by small phreatic and phreato-magmatic eruption. This eruptive activity is still ongoing. Deformation measurements at Nevado Del Ruiz volcano have been carried out since just after the tragic eruption of the 13th of November 1985. In 2007 seven new electronic tilt meters were set up to monitor the deformation. Significant uplift was measured from August 2007 to October 2010, for a total cumulative value of more than 500 microradians. From the end of 2011 to July 2012, moderate changes of uplift were detected for a total of 70 microradians. The analysis of these deformation data shows a pattern of surface displacement associated with an intrusion of new magma coming from a reservoir located approximately at a depth of approximately 8 km and accumulating in shallow reservoir less than 2 km beneath the main crater. We fit the data with both a spherical and a vertical spheroid source. The spherical source indicates the existence of an intrusion at a depth of 1823±1056 m with a volume change of (7±17)×106 m3 . The vertical spheroidal source suggests a source 1855 m deep with a volume change of 6×106 m3 . These results imply that while we have strong bounds on the depth of the intrusion, the actual volume of the source is less certain. Gas emission from Nevado del Ruiz volcano in April 7, 2012.

Ordoñez, M.; Lopez, C.; Cortes, G. P.; Londoño, J.; Battaglia, M.

2012-12-01

455

Els Fragments del Sacramentari de Sant Boi de Lluçanès (Vic. Bib. Espisc., Frag I\\/6)  

Microsoft Academic Search

Els disset folis del manuscrit Vic, Bib. Episc., frag. I\\/6 són les restes d'un sacramentari de tipus gregorià mixt, procedents de la parròquia de Sant Boi de Lluçanès. Foren escrites en l'últim quart del segle X, però, al segon quart del segle XII s'hi feren esmenes adaptant el seu cànon als models d'aquest segle. En això rau la seva singularitat.

Miquel dels Sants Gros i Pujol

2005-01-01

456

Analisis filogenetico del compas flamenco Jose-Miguel Diaz-Ba~nez *  

E-print Network

An´alisis filogen´etico del comp´as flamenco Jos´e-Miguel D´iaz-B´a~nez * Giovanna Farigu caracterizaci´on internacional del flamenco es la ejecuci´on de los ritmos de palmas en los que el metro musical´etico de los cinco patrones r´itmicos en comp´as de 12/8 del flamenco usando dos distancias de comparaci

Toussaint, Godfried T.

457

02-Oct-2006 MARTES 2006 at MoDELS 2006 1 TimeExceptions  

E-print Network

02-Oct-2006 MARTES 2006 at MoDELS 2006 1 TimeExceptions Time Exceptions in Sequence Diagrams Oddleif Halvorsen, Ragnhild Kobro Runde, Ã?ystein Haugen #12;02-Oct-2006 MARTES 2006 at MoDELS 2006 2 Time and the exceptional parts can be refined separately #12;02-Oct-2006 MARTES 2006 at MoDELS 2006 3 TimeExceptions Time

Runde, Ragnhild Kobro

458

Emisores LEPA, filosofía de manejo del agua en los pivotes centrales LEPA emitters, a philosophy of water management in the center  

Microsoft Academic Search

RESUMEN. Se hace una revisión y comentarios sobre las ventajas y limitantes del empleo del LEPA (Low Enery Precision Aplication) en los sistemas de riego de pivotes centrales. Estos sistemas o filosofía de manejo del agua para condiciones de escasez o mala calidad del líquido es una alternativa viable para la producción de alimentos. Introducida en la década del 80

Reynaldo Roque Rodés; Candelario Alemán García

2005-01-01

459

D.R. n.5024 del 01.08.2011 ClasseClasseClasseClasse LM-46 -Odontoiatria e protesi dentaria  

E-print Network

L/23 D.R. n.5024 del 01.08.2011 ClasseClasseClasseClasse LM-46 - Odontoiatria e protesi dentaria Nome del corsoNome del corsoNome del corsoNome del corso Odontoiatria e protesi dentaria Nome inglese formativi qualificanti della classe: LM-46 Odontoiatria e protesi dentaria I laureati nei corsi di laurea

Malerba, Donato

460

REGOLAMENTO DIDATTICO DEL CORSO DI LAUREA IN INFERMIERISTICA (ABILITANTE ALLA PROFESSIONE SANITARIA DI INFERMIERE)  

E-print Network

preventiva, curativa, palliativa e riabilitativa di natura tecnica relazionale ed educativa. Tale attività si di informatica adeguate per la comunicazione. OBIETTIVI FORMATIVI SPECIFICI E DESCRIZIONE DEL

Milano-Bicocca, Università

461

Duality between string junctions and D-branes on del Pezzo surfaces  

NASA Astrophysics Data System (ADS)

We revisit local mirror symmetry associated with del Pezzo surfaces in Calabi-Yau threefolds in view of five-dimensional N=1 E N theories compactified on a circle. The mirror partner of singular Calabi-Yau with a shrinking del Pezzo four-cycle is described as the affine 7-brane backgrounds probed by a D3-brane. Evaluating the mirror map and the BPS central charge we relate junction charges to RR charges of D-branes wrapped on del Pezzo surfaces. This enables us to determine how the string junctions are mapped to D-branes on del Pezzo surfaces.

Mohri, Kenji; Ohtake, Yukiko; Yang, Sung-Kil

2001-02-01

462

Therapy-related myeloid neoplasms with isolated del(20q): comparison with cases of de novo myelodysplastic syndrome with del(20q).  

PubMed

The isolated deletion of chromosome 20q [del(20q)] has been observed in both de novo and therapy-related cases of myelodysplastic syndrome (MDS). The clinicopathologic features of de novo MDS with isolated del(20q) are well characterized. However, relatively little is known about therapy-related myeloid neoplasms (t-MNs) with isolated del(20q). In this study, we identified five cases of t-MN and 26 cases of de novo MDS with isolated del(20q) over a 10-year period. All cases had a long latency interval from the treatment of the primary malignancy to the onset of t-MN, and all were associated with frequent bone marrow dysplasia. The del(20q) was the sole abnormality detected at the time of diagnosis of t-MN in three cases, six years prior to diagnosis in one case, and at the time of relapse of acute myeloid leukemia (AML) in one case. Three patients with therapy-related MDS (t-MDS) had a relatively indolent clinical course, whereas two patients presented with AML or developed AML shortly after t-MDS. The patients with de novo MDS with isolated del(20q) presented frequently with anemia and thrombocytopenia which were associated with bone marrow dysplasia. The median overall survival was 64 months. In all cases, del(20q) was present at the time of diagnosis. PMID:23357231

Kanagal-Shamanna, Rashmi; Yin, C Cameron; Miranda, Roberto N; Bueso-Ramos, Carlos E; Wang, Xiaohong Iris; Muddasani, Ramya; Medeiros, L Jeffrey; Lu, Gary

2013-01-01

463

The highly prevalent BRCA2 mutation c.2808_2811del (3036delACAA) is located in a mutational hotspot and has multiple origins.  

PubMed

BRCA2-c.2808_2811del (3036delACAA) is one of the most reported germ line mutations in non-Ashkenazi breast cancer patients. We investigated its genetic origin in 51 Spanish carrier families that were genotyped with 11 13q polymorphic markers. Three independent associated haplotypes were clearly distinguished accounting for 23 [west Castilla y León (WCL)], 20 [east Castilla y León (ECL)] and 6 (South of Spain) families. Mutation age was estimated with the Disequilibrium Mapping using Likelihood Estimation software in a range of 45-68 and 45-71 generations for WCL and ECL haplotypes, respectively. The most prevalent variants, c.2808_2811del and c.2803G > A, were located in a double-hairpin loop structure (c.2794-c.2825) predicted by Quikfold that was proposed as a mutational hotspot. To check this hypothesis, random mutagenesis was performed over a 923 bp fragment of BRCA2, and 86 DNA variants were characterized. Interestingly, three mutations reported in the mutation databases (c.2680G > A, c.2944del and c.2957dup) were replicated and 20 affected the same position with different nucleotide changes. Moreover, five variants were placed in the same hairpin loop of c.2808_2811del, and one affected the same position (c.2808A > G). In conclusion, our results support that at least three different mutational events occurred to generate c.2808_2811del. Other highly prevalent DNA variants, such as BRCA1-c.68_69delAG, BRCA2-c.5946delT and c.8537delAG, are concentrated in hairpin loops, suggesting that these structures may represent mutational hotspots. PMID:23929434

Infante, Mar; Durán, Mercedes; Acedo, Alberto; Sánchez-Tapia, Eva María; Díez-Gómez, Beatriz; Barroso, Alicia; García-González, María; Feliubadaló, Lídia; Lasa, Adriana; de la Hoya, Miguel; Esteban-Cardeñosa, Eva; Díez, Orland; Martínez-Bouzas, Cristina; Godino, Javier; Teulé, Alexandre; Osorio, Ana; Lastra, Enrique; González-Sarmiento, Rogelio; Miner, Cristina; Velasco, Eladio A

2013-11-01

464

Non-seasonality of births in Tierra del Fuego (Chile).  

PubMed

Tierra del Fuego is situated at the southern tip of the American continent, which conditions its environmental and climatic characteristics. The colonizing population arrived, at the end of the 19th century, from other Chilean regions (particularly from Chiloé) and diverse European countries, especially Britain and Croatia, but also Germany, Spain and Italy. In the present study, the existence of a seasonal pattern in 5430 births registered in the Chilean population of Tierra del Fuego from 1890 to 1995 was analysed. The analysis showed no seasonal distribution of births in the periods 1890-1920 and from 1946 to the present day, a phenomenon rarely reported in the literature. The absence of seasonality in birth distribution could be related to the great diversity in the origins of the population's families, the constant renovation of this and the declining importance of the administrative capital of the province of Tierra del Fuego, Porvenir, in favour of Punta Arenas, capital of the Magellanic region. In the period of maximum development of the capital of the province, a seasonal pattern was detected with a peak in April and a trough in October, which corresponds with a maximum of conceptions in July and, in general, during the early southern winter and a decline in births from late spring to mid-summer, with a trough in January. This birth distribution is interpreted as a subordination of activity and social life to the annual sheep cycle. In addition to temporal trends, the influence on the observed patterns of environmental parameters, father's occupation, seasonality of marriage and the origin of the parents were analysed. PMID:11023121

Pascual, J; García-Moro, C; Hernández, M

2000-01-01

465

Laboratori Nazionali del Gran Sasso and the ILIAS Initiative  

NASA Astrophysics Data System (ADS)

Laboratori Nazionali del Gran Sasso (LNGS) is actually the largest deep underground laboratory in the world completely devoted to fundamental science. In this talk I give a review of the main characteristics of the infrascructure and of the past and ongoing scientific activities. LNGS is taking part in the EU initiative ILIAS (Integrated Large Infrastructures for Astroparticle Physics). Within ILIAS LNGS is collaborating with the other three european deep underground sites: Laboratoire Soterrain de Modane (France), Laboratorio Subterraneo de Canfranc (Spain), and Boulby Mine Underground Laboratory (UK).

Ferrari, N.

2005-04-01

466

Distribución del continuo ultravioleta e infrarrojo en estrellas Be  

NASA Astrophysics Data System (ADS)

Estamos interesados en interpretar los excesos de flujo infrarrojo y/o ultravioleta observados en estrellas Be con respecto al de estrellas B normales, así como su posible correlación. Una envoltura rodeando la estrella distingue una estrella Be de una B normal; para explicar las observaciones es necesario entonces tener en cuenta todos los posibles procesos físicos que en ella tienen lugar. Adoptando un modelo atmosférico específico, hemos estudiado el proceso de recombinación dielectrónica de metales como MgII y FeII, teniendo en cuenta la posible influencia de la opacidad del medio en el flujo emitido.

Cruzado, A.; Ringuelet, A.; di Rocco, H.

467

Gynandromorphs in mosquitoes (Diptera: Culicidae) from Valle del Cauca, Colombia.  

PubMed

Gynandromorphs of Culex nigripalpus Theobald (2), Cx. pedroi Sirivanakarn and Belkin (1) and Aedes albopictus (Skuse) (2) are described. Two individuals of the latter species were reared in the laboratory, while the remaining three specimens were wild-caught with different traps in rural areas in Valle del Cauca department, southwestern Colombia. All of the individuals were mounted on microscopic slides with Canada balsam. From each mosquito, main morphological characteristics are described and illustrated. Due to the paucity of information about this subject, these findings as well as other relevant cases are discussed. PMID:18641900

Barreto, Mauricio; Burbano, María E; Barreto, Pablo

2008-01-01

468

Modelo analítico del efecto de PRS sobre satélites GPS  

NASA Astrophysics Data System (ADS)

El sistema GPS (Global Position System) es, hoy en día, la herramienta de navegación y posicionamiento más potente y lo será sin duda en la próxima década. Gran parte de su valiosa utilidad se debe a la alta precisión que permite lograr y ésta, a su vez, depende, entre otras causas, de la precisión con que se conocen las órbitas de los satélites. La presión de radiación solar (PRS) fija el límite de la precisión con que pueden calcularse en la actualidad las efemérides satelitarias. El objetivo de este trabajo es proponer una mejor resolución de este fenómeno. El modelo analítico aquí presentado, se basa en el análisis del comportamiento de los residuos de un ajuste por mínimos cuadrados en el que se utiliza el modelo de PRS propuesto por Beutler. El mismo consiste en un modelo determinista del fenómeno con dos parámetros libres. Los resultados obtenidos ponen de manifiesto que, aún después de aplicar dichos parámetros, prevalecen en los residuos efectos semidiurnos en las componentes radial,tangencial y normal. Estos resultados obtenidos se comparan con los de un trabajo desarrollado por el Instituto de Berne (Beutler et al., 1994), en el que se utilizaron como pseudo-observaciones las órbitas precisas del IGS (CODE). El intervalo de integración escogido por este centro fueron las semanas 680 y 681. En resumen se tienen arcos de 14 días para todos los satélites, donde las efemérides precisas de los mismos para los 14 días fueron utilizados como pseudo-observaciones. El modelo de fuerza que empleó dicho centro fue básicamente el tradicional en lo que respecta al modelo de las fuerzas gravitacionales, y para la PRS utilizo el modelo standard de Beutler. Los parámetros de este modelo junto con las 6 condiciones iniciales (posición y velocidad) fueron ajustados por el método general de mínimos cuadrados. Los residuos en la componente radial, tangencial y normal, para los satélites con un buen comportamiento, presentan una componente semidiurna. El modelo analítico planteado en este trabajo, predice el comportamiento de los residuos que se observan en las publicaciones más recientes. Esto abre el camino para plantear una estimación distinta de las incógnitas del problema, basado en el método de colocación por mínimos cuadrados. Ello requiere modelar estadísticamente la señal debida a las componentes de la PRS que no son tomadas en cuenta en el modelo determinista.

Meza, A.; Brunini, C.; Usandivaras, J. C.

469

Optical photometry and spectroscopy of Nova Del 2013  

NASA Astrophysics Data System (ADS)

We report optical BV photometry and spectroscopy of Nova Del 2013, carried out between August 14.88 UT and August 15.08 UT. Using a 60 cm Cassegrain telescope at the Nicolaus Copernicus University Observatory (Torun, Poland) we estimated the V brightness of the Nova to be 6.31+/-0.02 mag and 6.18+/-0.03 mag on Aug. 14.94 UT and Aug. 15.02 UT respectively. HD 194113 (F2, V=8.00 mag) was used as a comparison star.

Tomov, T.; Ilkiewicz, K.; Swierczynski, E.; Belcheva, M.; Dimitrov, D.

2013-08-01

470

Deadly Lahars from Nevado del Ruiz, Colombia: November 13, 1985  

NSDL National Science Digital Library

This web site describes a series of Lahars that occurred from the Nevado del Ruiz volcano in the Andes mountains, the northernmost and highest volcano in Colombia. Beginning in November 1984, the volcano began showing clear signs of unrest. An explosive eruption from Ruiz's summit crater on November 13, 1985, at 9:08 p.m. generated an eruption column and sent a series of pyroclastic flows and surges across the volcano's summit. Within minutes, pumice and ash began to fall to the northeast along with heavy rain that had started earlier in the day. Within four hours, lahars had traveled 100 km and left behind a wake of destruction: more than 23,000 people killed, about 5,000 injured, and more than 5,000 homes destroyed along the Chinchina, Guali, and Lagunillas rivers and destroying the town of Armero, Columbia. This deadly eruption of Nevado del Ruiz offers lessons on the generation of lahars for scientists, emergency-response professionals, and communities located downstream of such ice- and snow-covered volcanoes. The narrative is illustrated with 9 photographs.

N. Banks

471

EJERCICIO Y LA DETECCION DEL MAL AGUDO DE MONTAÑA GRAVE  

PubMed Central

El Mal Agudo de Montaña (MAM) es un conjunto de síntomas inespecíficos padecidos por sujetos que ascienden rápidamente desde baja a alta altura sin adecuada aclimatación. Usualmente es autolimitado, pero las formas graves (edema pulmonar y cerebral) pueden causar la muerte. La hipoxemia exagerada en reposo está relacionada con el desarrollo de MAM pero su valor predictivo es limitado. Dado que el ejercicio en altura se acompaña de mayor hipoxemia y síntomas, postulamos el valor predictivo de un simple test de ejercicio para pronosticar MAM grave. Se estudió el valor predictivo de la saturación de oxígeno en reposo y ejercicio submáximo a 2 700m y 4 300m en 63 sujetos que ascendían al cerro Aconcagua (6 962m). Se consideró desaturación de oxígeno con ejercicio a una disminución >=5% respecto al reposo. Se utilizó la escala de Lake-Louise para establecer la presencia de MAM grave. 6 sujetos presentaron MAM grave (9.5%) y requirieron evacuación. La saturación de oxígeno en reposo a 2 700m no fue significativa para clasificar sujetos que luego desarrollaron MAM grave. Por el contrario, la asociación de desaturación durante el ejercicio a 2 700m más la saturación inapropiada en reposo a 4 300m fue significativa para clasificar a los sujetos que desarrollaron MAM grave con un valor predictivo positivo de 80% y un valor predictivo negativo del 97%. Nuestros resultados son relevantes para el montañismo y sugieren la adición de un simple test de ejercicio en la predicción del MAM grave. PMID:20228017

Garófoli, Adrián; Montoya, Paola; Elías, Carlos; Benzo, Roberto

2012-01-01

472

El acceso al episcopado en la Monarqua Hispnica (1789-1800)* La ltima dcada del siglo XVIII, clave por las repercusiones polticas del primer ciclo  

E-print Network

del siglo XVIII, con el objetivo de comprobar hasta qué punto los factores de uno u otro origen, Francis: Kingship. The Politics of Enchantment, Blackwell, Malden/Oxford/Carlton, 2006, pp. 140-142. 2 AGS

Paris-Sud XI, Université de

473

La revisión del estudio de prevención de cáncer de próstata indica no haber beneficio del uso de suplementos de selenio y de vitamina E  

Cancer.gov

La revisión inicial, independiente, de los datos del estudio SELECT, sigla en inglés del Estudio del Selenio y la Vitamina E para Prevenir el Cáncer, financiado por el Instituto Nacional del Cáncer (NCI) y otros institutos que comprenden los Institutos Nacionales de la Salud (NIH), indica que los suplementos de selenio y de vitamina E, tomados juntos o por separado, no impiden el cáncer de próstata. Los datos indicaron también dos tendencias preocupantes: un pequeño aumento aunque no significativo estadísticamente en el número de casos de cáncer de próstata entre los más de 35 000 hombres de 50 años y mayores en el estudio que tomaron sólo vitamina E, y un aumento pequeño aunque no significativo estadísticamente en el número de casos de diabetes de aparición en edad adulta en los hombres que tomaron sólo el selenio.

474

Decreto n. 4076 IL RETTORE VISTI i DD.RR. n. 1720 del 24 aprile e n. 2131 del 23 maggio  

E-print Network

.ssa Addolorata SALVATORE PROFESSORI DI RUOLO DI II FASCIA: - prof.ssa Nicoletta DEL BUONO - prof. Roberto LA SCALA - prof. Marcello DE GIOSA RICERCATORI: - dott.ssa Anna GERMINARIO - dott. Vincenzo Carmine

Malerba, Donato

475

Consejo Asesor Consejo Asesor del Decanato de Estudios Tecnolgicos Acta 04-2012 del 11/05/12 Pg. 1 de 6  

E-print Network

Lic. Comercio Internacional), María Fátima Pino, Coordinador de Administración Aduanera, Martín Durán (Coordinador de Postgrado, Tecnología e Ingeniería Electrónica), Enio Ortiz (Coordinador de Comercio Exterior y 24 Organización empresarial 19 50 Administración del Transporte 11 18 Comercio Exterior 71 137

Vásquez, Carlos

476

Consejo Asesor Consejo Asesor del Decanato de Estudios Tecnolgicos Acta 07-2012 del 28/09/12 Pg. 1 de 6  

E-print Network

(Coordinador de Comercio Exterior y Lic. Comercio Internacional), María Fátima Pinho (Coordinadora de intercambio internacional 4. INFOCARRERA 2013 5. Lapsos de corrección de inscripción 6. Actualización de la organización del I Simposio Internacional. Anuncia que próximamente se recibirán más donaciones

Vásquez, Carlos

477

Identification Los adultos del barrenador del fresno son ms grandes y de un verde ms brillante que las especies nativas de Agrilus en Norteamrica  

E-print Network

la cubierta de las alas de un verde esmeralda y metálico más oscuro. La parte superior del abdomen dos años para completar una generación en regiones con climas más fríos. En el 2003, la emergencia de

Balser, Teri C.

478

ESTUDIO DE IDENTIFICACIN DE ZONAS DE RIESGOS EN LOS  

E-print Network

.2. Mapas multiamenazas 21 4.3. Mapas de elementos expuestos 24 4.3.1 Mapas de población expuesta (densidad y nivel de vulnerabilidad por densidad) 24 4.3.2 Mapas de elementos materiales expuestos 25 4

Boyer, Edmond

479

RADIO OBSERVATRIO DO ITAPETINGA, ATIBAIA, SP ZONA DE SILNCIO ELTRICO.  

E-print Network

interferências indesejáveis. Mesmo o uso desses instrumentos para monitorar sinais de satélites em torno da Terra instrumentos de alta sensibilidade, tanto para estudar o universo, quanto para monitorar sinais de satélites

480

FERTILIZATION BY SPERM MICROINJECTION AND ZONA-DRILLING: METHODS  

EPA Science Inventory

Successful microinjection of sperm or sperm nuclei into oocytes depends upon many factors. For example, injection needles must be large enough to pick up a sperm (nucleus) yet not so large as to kill the oocyte. The suction/pressure system should be very precisely controlled so a...

481

Els mol·luscs gasteròpodes (Mollusca, Gasteropoda) del massís de Sant Llorenç del Munt i la serra de l'Obac  

Microsoft Academic Search

Es cataloga la fauna de gasteròpodes del Parc Natural de Sant Llorenç del Munt i l’Obac com a contribució al coneixement de la seva biodiversitat. Amb aquesta finalitat s’han dut a terme prospeccions malacològiques per estudiar les diferents comunitats naturals i per conèixer els requeriments biològics de cada espècie. A la vegada, s’ha portat a terme una recopilació bibliogràfica. El

Vicenç Bros

2000-01-01

482

El Instituto Nacional del Cáncer publica nuevo atlas de mortalidad por cáncer  

Cancer.gov

El Instituto Nacional del Cáncer (NCI, por sus siglas en inglés) ha publicado un nuevo atlas, el Atlas de Mortalidad por Cáncer en los Estados Unidos, 1950-94, que muestra los patrones geográficos de las tasas de mortalidad por cáncer durante más de cuatro décadas, en más de 3.000 condados a lo largo del país.

483

Adaptabilidad y cohesión familiar, implicación parental en conductas autorregulatorias, autoconcepto del estudiante y rendimiento académico  

Microsoft Academic Search

En este estudio se analiza la relación existente entre la adaptabilidad y la cohesión familiar, así como la conducta autorregulatoria de los padres en relación a su comportamiento con los hijos, en general, y en su implicación en el ámbito del estudio, en particular. También se estudia el tipo de relación que tales variables familiares mantienen con diferentes dimensiones del

Julio A. González-Pienda; José C. Núñez; Luis Álvarez; Cristina Roces; Soledad González-Pumariega; Paloma González; Roberto Muñiz; Antonio Valle; Ramón G. Cabanach; Susana Rodríguez; Ana Bernardo

484

AE0200 CINEMA AL CAMPUS Descripci: els amants del cinema tenen la possibilitat de veure una  

E-print Network

AE0200 CINEMA AL CAMPUS AE0210 AE0220 Descripció: els amants del cinema tenen la possibilitat de Indicat per a alumnes de diversos estudis, persones interessades en el cinema i per al públic en general CINEMACAMPUS AE0211 AE0212 Descripció: la idea de donar a conèixer les particularitats del cinema com

Oro, Daniel

485

Una investigación cualitativa y etnográfica sobre el valor educativo y el uso didáctico del patrimonio cultural  

Microsoft Academic Search

Se han hecho valiosas aportaciones acerca del estudio del patrimonio cultural desde la perspectiva de las diversas ciencias sociales y de la didáctica, pero dichas aportaciones parece que han encontrado escaso eco en la enseñanza-aprendizaje de las ciencias sociales. Para acercarnos al conocimiento de lo que realmente se entiende por patrimonio cultural y su tratamiento en la enseñanza, a nivel

Neus González Monfort

2008-01-01

486

Independent External Peer Review Rio Grande Floodway, San Acacia to Bosque Del Apache,  

E-print Network

Independent External Peer Review Rio Grande Floodway, San Acacia to Bosque Del Apache, New Mexico and maintenance Office of Management and Budget Probability of Unsatisfactory Performance SADD San Acacia performed an Independent External Peer Review (IEPR) of the Rio Grande Floodway, San Acacia to Bosque Del

US Army Corps of Engineers

487

Variacin Termal sobre la Superficie Ocenica del Caribe Samuel Pacheco-Cherena  

E-print Network

censor AVHRR (Advance Very High Resolution Radiometer) a bordo del satélite NOAA-18, cuya campana fue y AVHRR-3, que es el que utiliza en estos momentos el NOAA-18. (Figura 3). Figura 2. Especificaciones adicionales del censor AVHRR. El NOAA-18 es parte de una nueva serie de satélit

Gilbes, Fernando

488

EL MODELO DE REGULACIÓN DEL SERVICIO PÚBLICO DE TELECOMUNICACIONES EN COLOMBIA  

Microsoft Academic Search

En este artículo se analiza el desarrollo del modelo de regulación en la prestación del servicio público de telecomunicaciones en Colombia, a partir de la liberalización de los servicios públicos domiciliarios (SPD) establecida en el marco normativo de la Constitución Política de Colombia de 1991 y la Ley 142 de 1994. Basado en la revisión de la literatura existente sobre

Raúl Andrés Tabarquino Muñoz

2010-01-01

489

Presidio AVA Assicurazione Qualit della Didattica_ agg. 2 del 19/06/2014  

E-print Network

Presidio AVA Assicurazione Qualità della Didattica_ agg. 2 del 19/06/2014 1 Assicurazione Qualità) Attuazione del Sistema per l'Assicurazione Qualità 6) Procedure a supporto #12;Presidio AVA Presidio AVA di Ateneo; le azioni per il miglioramento continuo dei processi di gestione della qualità

490

Content Analysis Schedule for Bilingual Education Programs: Del Valle Bilingual Education Program.  

ERIC Educational Resources Information Center

This content analysis schedule for the Del Valle Bilingual Education Program of Del Valle, Texas, presents information on the history, funding, and scope of the project. Included are sociolinguistic process variables such as the native and dominant languages of students and their interaction. Information is provided on staff selection and the…

Ehrlich, Roselin; Shore, Marietta Saravia

491

USM prot. 4627 del 11/02/2011 Al Personale Tecnico ed Amministrativo  

E-print Network

riconoscimento della patologia grave. In mancanza di tali documenti non sarà possibile ricondurre il certificato telematico alla patologia grave e l'assenza sarà considerata malattia ai sensi del punto 8 dell'art. 35 del C

De Cindio, Fiorella

492

EL COMERCIO ELECTRÓNICO EN PAÍSES EN DESARROLLO: LA PLANEACIÓN PARA EL ÉXITO DEL NEGOCIO  

Microsoft Academic Search

Desde un enfoque que identifica al conocimiento como una fuente de capacidad de competencia en el contexto social, organizacional e individual se explica al Comercio electrónico como un proceso estratégico de las organizaciones de negocio, en el ámbito económico actual. En particular se enfatiza la trascendencia del proceso específico de planeación para el éxito del negocio a través de la

L. P. Carrillo

2010-01-01

493

Aprovaci de l'oferta de formaci permanent del curs 2013-14 (cursos pendents)  

E-print Network

de juliol de 2014 #12;PROGRAMES DE FORMACIÓ PERMANENT DE POSTGRAU. CURS 2013-14. ARQUITECTURA Edició Lloc d'impartició Aprovació Arquitectura del Paisatge Departament d'Urbanisme i Ordenació del Territori 31 Barcelona CG 58/7 2013 Arquitectura i Medi Ambient: Integració d'Energies Renovables a l'Arquitectura

Yannuzzi Sanchez, Marcelo

494

OFERTA DE PROGRAMES DE FORMACI PERMANENT DEL CURS ACADMIC 2011/12  

E-print Network

OFERTA DE PROGRAMES DE FORMACIÓ PERMANENT CURS 2011-12 ARQUITECTURA, EDIFICACIÓ I URBANISME Màster Nom'impartició Arquitectura del Paisatge * Departament d'Urbanisme i Ordenació del Territori 29 Barcelona i Milà Arquitectura i Medi Ambient: Integració d'Energies Renovables a l'Arquitectura * Departament de Construccions

Politècnica de Catalunya, Universitat

495

ANLISIS DE CAMBIOS EN LA CALIDAD DEL AGUA EN PUERTO RICO UTILIZANDO SISTEMAS DE INFORMACIN GEOGRFICA  

E-print Network

ANÁLISIS DE CAMBIOS EN LA CALIDAD DEL AGUA EN PUERTO RICO UTILIZANDO SISTEMAS DE INFORMACIÓN maduros son beneficiosos para la calidad del agua en Puerto Rico. Este resultado se obtuvo integrando, mediante modelos, la información de distintas capas geográficas de Puerto Rico:(1) calidad

Gilbes, Fernando

496

Las raíces teóricas del conflicto economía\\/ecología y algunos desarrollos posteriores a Walras  

Microsoft Academic Search

Las formas de relación del hombre con la naturaleza han cambiado a lo largo de la historia y las modificaciones en la configuración del sistema económico parecen reflejar claramente estas mutaciones. Así, durante el feudalismo el núcleo de lo económico se instala en la producción agraria y el dominio, mas no la propiedad sobre la tierra genera poder social. En

Luis Jair Gómez G

1997-01-01

497

DISEÑO DE UNA PLANTA PILOTO PARA EL TRATAMIENTO DEL RESIDUAL DE UNA SALINA  

Microsoft Academic Search

En el proceso de extracción de cloruro de sodio a partir de agua de mar queda una salmuera residual rica en sales de sodio y magnesio que al ser tratadas químicamente y al ser evaporada permite recuperar aproximadamente el 75% del cloruro de sodio que queda en dicho residual, lo que puede reducir la contaminación ambiental del litoral y generar

Mariana Estela Colombat Rodríguez; Amada Lissett Colombat Rodríguez

2011-01-01

498

Un marco institucional para la gestión del medio ambiente y para la sostenibilidad agrícola  

Microsoft Academic Search

En la primera parte de este trabajo se analiza el significado que tiene la agricultura sostenible en la agenda del desarrollo, precisando que la creciente preocupación por las sostenibilidad de la agricultura deriva no sólo de la preocupación más general sobre la preservación de las condiciones ambientales y de cambios en las condiciones del Comercio Internacional que han venido incorporando

Jesús Antonio Bejarano

1997-01-01

499

Indicadores para la Gestión de Riesgos: Aplicación del Sistema de Indicadores 1980 ¿ 2000: Bolivia  

Microsoft Academic Search

Los desastres son eventos socio-ambientales cuya materialización es el resultado de la construcción social del riesgo. Por lo tanto, su reducción debe hacer parte de los procesos de toma de decisiones, no sólo en el caso de reconstrucción posdesastre, sino también en la formulación de políticas públicas y la planificación del desarrollo. Por esta razón, es necesario fortalecer el desarrollo

Luis Eduardo Yamín; Omar D. Cardona

2006-01-01

500

Decreto Rettorale n. 272 del 19 maggio 2008 Pagina 1 di 11 numero: 272  

E-print Network

Pathfinder e gli sviluppi di laboratorio per LISA" n. 1 borsa di studio Istituto Nazionale di Fisica Nucleare maggio 2008 oggetto: Bando Scuola di Dottorato di Ricerca in "Fisica" 24°ciclo IL RETTORE Vista la Legge Dipartimento di Fisica; Vista la relazione del Nucleo di Valutazione Interna del 16 gennaio 2007 in ordine ai