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Sample records for zonas pesqueras del

  1. MANEJO DEL NIVEL DE NAPAS EN ZONAS DE LLANURA

    E-print Network

    Nacional de San Luis, Universidad

    suelo #12;Angel N. Menéndez PRESENTACIÓN · Ciclo hidrológico en zona pampeana · Manejo del agua · Modelación del balance hídrico · Análisis de canalizaciones · Análisis de cambio de uso del suelo #12;Angel N suelo #12;Angel N. Menéndez MANEJO DEL AGUA · Canalizaciones · Cambio del uso del suelo #12;Angel N

  2. Incentivos para atraer y retener personal de salud de zonas rurales del Perú: un estudio cualitativo

    PubMed Central

    Huicho, Luis; Canseco, Francisco Díez; Lema, Claudia; Miranda, J. Jaime; Lescano, Andrés G.

    2014-01-01

    El objetivo fue identificar incentivos de atracción y retención en zonas rurales y distantes de Ayacucho, Perú. Fueron realizadas entrevistas en profundidad con 80 médicos, enfermeras, obstetras y técnicos (20 por grupo) de las zonas más pobres y con 11 funcionarios. No existen políticas sistemáticas de atracción y retención de personal de salud en Ayacucho. Los principales incentivos, en orden de importancia, fueron mejoras salariales, oportunidades de formación y capacitación, estabilidad laboral y nombramiento, mejoras en infraestructura y equipos, e incremento del personal. Se mencionaron también mejoras en la vivienda y alimentación, mayor cercanía con la familia y reconocimiento por el sistema de salud. Existen coincidencias y singularidades entre los distintos grupos sobre los incentivos clave para estimular el trabajo rural, que deben considerarse al diseñar políticas públicas. Las iniciativas del Estado deben comprender procesos rigurosos de monitoreo y evaluación, para asegurar que las mismas tengan el impacto deseado. PMID:22488318

  3. Estudios de la Zona No Saturada del Suelo Vol. VII. F.J. Samper Calvete y A. Paz Gonzlez, 2005 INTERACCIN ENTRE LA EROSIN EN REGUEROS, CONTENIDO DE HUMEDAD EDFICA Y

    E-print Network

    Espigares, Tíscar

    Estudios de la Zona No Saturada del Suelo Vol. VII. F.J. Samper Calvete y A. Paz González, 2005 345 mecanismos de control de la humedad del suelo por la erosión están relacionados con la formación de costras superficiales, la reducción de la rugosidad superficial del suelo y la evacuación eficiente de la escorrentía

  4. CREAPGINA 32 as napas freticas representan el techo de la zona satura-

    E-print Network

    Nacional de San Luis, Universidad

    CREAPÁGINA 32 as napas freáticas representan el techo de la zona satura- da de agua del perfil de, además, el desarrollo de reglas empíricas de decisión que consideran el posi- ble aporte de agua freática presenta un compro- miso entre la cantidad y calidad de información que se busca generar y el esfuerzo que

  5. Estudio de seeing en la zona del Cerro Champaqui (I)

    NASA Astrophysics Data System (ADS)

    Diaz, R. J.; Eikenberry, S.; Scott, J.; Levato, H.; Firpo, V.; Farina, C.; Piroddi, D.; Jamud, N.; Bosch, G.; Mudrik, A.; Guzzo, P.; Donoso, V.; Recabarren, P.; Seifer, E.

    We report the results of the most recent seeing feasibility study performed in the region of Cerro Champaqui (2800m) at the mountain range of Sierras Grandes at the Province of Cordoba. We also describe the high frequency DIMM device built for this and other seeing samplings obtained at the provinces of San Juan; San Luis and Cordoba. This work is part of a long term project started in 2006; in search of sites of very low turbulence and suited for near infrared telescopes with active and adaptive optics. Two of the sites have been monitored during a total of 46 nights distributed in six months of the period 2011-2012. The preliminary results suggest the existence of `sub-arcsecond' seeing conditions during extended periods of time in at least one location in the mountain range in the SW of Cordoba and NE of San Luis provinces. FULL TEXT IN SPANISH

  6. Mechanics of sperm-egg interaction at the zona pellucida.

    PubMed Central

    Baltz, J M; Katz, D F; Cone, R A

    1988-01-01

    Mammalian sperm traverse several layers of egg vestments before fertilization can occur. The innermost vestment, the zona pellucida, is a glycoprotein shell, which captures and tethers the sperm before they penetrate it. We report here direct measurements of the force required to tether a motile human sperm as well as independent calculations of this force using flagellar beat parameters observed for sperm of several species on their homologous zonae. We have compared these sperm-generated forces with the calculated tensile strength of sperm-zona bonds, and found that a motile sperm can be tethered, at least temporarily, by a single bond. Therefore, sperm can be captured by the first bond formed and tethered permanently by a few. The sperm cannot subsequently penetrate the zona unless the bonds are first eliminated. However, premature elimination would simply allow the sperm to escape. Therefore, not only must the bonds be eliminated, but the timing of this must be regulated so that the sperm is already oriented toward the egg and beginning to penetrate as the bonds are broken. Images FIGURE 6 PMID:3224150

  7. Structural organization of the zona incerta of the dog diencephalon.

    PubMed

    Gorbachevskaya, A I; Chivileva, O G

    2008-07-01

    Studies performed using the Nissl and Kluver-Barrera methods for analysis of the organization of fibers, morphological neuron types, and neuron density distribution were undertaken to map the zona incerta of the diencephalon of the dog brain; five individual sectors were identified, whose boundaries were further identified by histochemical detection of NADPH-diaphorase-positive neurons. PMID:18607735

  8. Viscous forces are predominant in the zona pellucida mechanical resistance

    NASA Astrophysics Data System (ADS)

    Papi, Massimiliano; Maiorana, Alessandro; Douet, Cécile; Maulucci, Giuseppe; Parasassi, Tiziana; Brunelli, Roberto; Goudet, Ghylène; De Spirito, Marco

    2013-01-01

    The zona pellucida (ZP) is a multilayer glycoprotein spherical shell surrounding mammalian eggs. The ZP's mechanical response plays a crucial role in mammalian fertilization and is a parameter commonly adopted in "in vitro fertilization" to characterize the oocytes quality. While it is assumed that ZP mechanical response is purely elastic, here we prove that dissipative forces cannot be neglected. Physiologically, this evidence implies that an increase in the spermatozoa motility can induce dramatic changes on the ZP reaction force turning ZP shell in an impenetrable barrier leading to fertility impairments.

  9. Nanoscale characterization of the biomechanical hardening of bovine zona pellucida

    PubMed Central

    Boccaccio, Antonio; Frassanito, Maria Cristina; Lamberti, Luciano; Brunelli, Roberto; Maulucci, Giuseppe; Monaci, Maurizio; Papi, Massimiliano; Pappalettere, Carmine; Parasassi, Tiziana; Sylla, Lakamy; Ursini, Fulvio; De Spirito, Marco

    2012-01-01

    The zona pellucida (ZP) is an extracellular membrane surrounding mammalian oocytes. The so-called zona hardening plays a key role in fertilization process, as it blocks polyspermy, which may also be caused by an increase in the mechanical stiffness of the ZP membrane. However, structural reorganization mechanisms leading to ZP's biomechanical hardening are not fully understood yet. Furthermore, a correct estimate of the elastic properties of the ZP is still lacking. Therefore, the aim of the present study was to investigate the biomechanical behaviour of ZP membranes extracted from mature and fertilized bovine oocytes to better understand the mechanisms involved in the structural reorganization of the ZP that may lead to the biomechanical hardening of the ZP. For that purpose, a hybrid procedure is developed by combining atomic force microscopy nanoindentation measurements, nonlinear finite element analysis and nonlinear optimization. The proposed approach allows us to determine the biomechanical properties of the ZP more realistically than the classical analysis based on Hertz's contact theory, as it accounts for the nonlinearity of finite indentation process, hyperelastic behaviour and material heterogeneity. Experimental results show the presence of significant biomechanical hardening induced by the fertilization process. By comparing various hyperelastic constitutive models, it is found that the Arruda–Boyce eight-chain model best describes the biomechanical response of the ZP. Fertilization leads to an increase in the degree of heterogeneity of membrane elastic properties. The Young modulus changes sharply within a superficial layer whose thickness is related to the characteristic distance between cross-links in the ZP filamentous network. These findings support the hypothesis that biomechanical hardening of bovine ZP is caused by an increase in the number of inter-filaments cross-links whose density should be higher in the ZP inner side. PMID:22675161

  10. Laser zona drilling does not induce hsp70i transcription in blastomeres of eight-cell

    E-print Network

    Wangh, Lawrence J.

    Laser zona drilling does not induce hsp70i transcription in blastomeres of eight-cell mouse embryos To assess whether zona drilling with a 1,480-nm laser induces heat shock in eight-cell embryos, we measured hsp70i RNA levels in sets of single blastomeres isolated after laser treatment of mouse embryos

  11. Semirido: un desafo para la CienciaSemirido: un desafo para la Ciencia del Suelodel Suelo

    E-print Network

    Nacional de San Luis, Universidad

    Semiárido: un desafío para la CienciaSemiárido: un desafío para la Ciencia del Suelodel Suelo 13 al(SL), Argentina DIFERENTES USOS DEL SUELO: CONSECUENCIAS SOBRE BALANCE HÍDRICO Y DRENAJE PROFUNDO EN ZONAS aguas y suelos. ¿Se desarrollan procesos similares ante el reciente avance de la agricultura sobre los

  12. envelope of abalone eggs Rapidly evolving zona pellucida domain proteins are a major component of the vitelline

    E-print Network

    Aagaard, Jan

    envelope of abalone eggs Rapidly evolving zona pellucida domain proteins are a major component zona pellucida domain proteins are a major component of the vitelline envelope of abalone eggs Jan E) Proteins harboring a zona pellucida (ZP) domain are prominent components of vertebrate egg coats. Although

  13. ANGIOTENSIN II REGULATES ADRENAL VASCULAR TONE THROUGH ZONA GLOMERULOSA CELL-DERIVED EETS AND DHETS

    PubMed Central

    Kopf, Phillip G.; Gauthier, Kathryn M.; Zhang, David X.; Falck, John R.; Campbell, William B.

    2011-01-01

    Elevated concentrations of aldosterone are associated with several cardiovascular diseases. Angiotensin II increases aldosterone secretion and adrenal blood flow. This concurrent increase in steroidogenesis and adrenal blood flow is not understood. We investigated the role of zona glomerulosa cells in the regulation of vascular tone of bovine adrenal cortical arteries by angiotensin II. Zona glomerulosa cells enhance endothelium-dependent relaxations to angiotensin II. The zona glomerulosa cell-dependent relaxations to angiotensin II are unchanged by removing the endothelium-dependent response to angiotensin II. These zona glomerulosa cell-mediated relaxations are ablated by cytochrome P450 inhibition, epoxyeicostrienoic acid antagonism, and potassium channel blockade. Analysis of zona glomerulosa cell epoxyeicosatrienoic acid production by liquid chromatography/mass spectrometry demonstrates an increase in epoxyeicosatrienoic and dihydroxyeicosatrienoic acids with angiotensin II stimulation. These epoxyeicosatrienoic and dihydroxyeicosatrienoic acids produced similar concentration-dependent relaxations of adrenal arteries, which were attenuated by epoxyeicosatrienoic acid antagonism. Whole cell potassium current of adrenal artery smooth muscle cells were increased by angiotensin II stimulation in the presence of zona glomerulosa cells but decreased in the absence of zona glomerulosa cells. This increase in potassium current was abolished by iberiotoxin. Similarly, 14,15-epoxyeicosatrienoic acid induced concentration-dependent increases in potassium current, which was abolished by iberiotoxin. Zona glomerulosa cell aldosterone release is not directly altered by epoxyeicosatrienoic acids. These data suggest that angiotensin II stimulates zona glomerulosa cells to release epoxyeicosatrienoic and dihydroxyeicosatrienoic acids, resulting in potassium channel activation and relaxation of adrenal arteries. This provides a mechanism by which Ang II concurrently increases adrenal blood flow and steroidogenesis. PMID:21199991

  14. Boundaries to membranes : the urban project revisited : an urban strategy for Rio de Janeiro, Zona Norte

    E-print Network

    Dudek, Phebe (Phebe Helena Melania)

    2014-01-01

    This thesis investigates urban boundaries in the North Zone of Rio de Janeiro. The Zona Norte transitioned in the last hundred years from a rural outskirts area of Rio, into its industrial hinterland, into a fully urbanized ...

  15. Amyloid properties of the mouse egg zona pellucida.

    PubMed

    Egge, Nathan; Muthusubramanian, Archana; Cornwall, Gail A

    2015-01-01

    The zona pellucida (ZP) surrounding the oocyte is an extracellular fibrillar matrix that plays critical roles during fertilization including species-specific gamete recognition and protection from polyspermy. The mouse ZP is composed of three proteins, ZP1, ZP2, and ZP3, all of which have a ZP polymerization domain that directs protein fibril formation and assembly into the three-dimensional ZP matrix. Egg coats surrounding oocytes in nonmammalian vertebrates and in invertebrates are also fibrillar matrices and are composed of ZP domain-containing proteins suggesting the basic structure and function of the ZP/egg coat is highly conserved. However, sequence similarity between ZP domains is low across species and thus the mechanism for the conservation of ZP/egg coat structure and its function is not known. Using approaches classically used to identify amyloid including conformation-dependent antibodies and dyes, X-ray diffraction, and negative stain electron microscopy, our studies suggest the mouse ZP is a functional amyloid. Amyloids are cross-? sheet fibrillar structures that, while typically associated with neurodegenerative and prion diseases in mammals, can also carry out functional roles in normal cells without resulting pathology. An analysis of the ZP domain from mouse ZP3 and ZP3 homologs from five additional taxa using the algorithm AmylPred 2 to identify amyloidogenic sites, revealed in all taxa a remarkable conservation of regions that were predicted to form amyloid. This included a conserved amyloidogenic region that localized to a stretch of hydrophobic amino acids previously shown in mouse ZP3 to be essential for fibril assembly. Similarly, a domain in the yeast protein ?-agglutinin/Sag 1p, that possesses ZP domain-like features and which is essential for mating, also had sites that were predicted to be amyloidogenic including a hydrophobic stretch that appeared analogous to the critical site in mouse ZP3. Together, these studies suggest that amyloidogenesis may be a conserved mechanism for ZP structure and function across billions of years of evolution. PMID:26043223

  16. Amyloid Properties of the Mouse Egg Zona Pellucida

    PubMed Central

    Egge, Nathan; Muthusubramanian, Archana; Cornwall, Gail A.

    2015-01-01

    The zona pellucida (ZP) surrounding the oocyte is an extracellular fibrillar matrix that plays critical roles during fertilization including species-specific gamete recognition and protection from polyspermy. The mouse ZP is composed of three proteins, ZP1, ZP2, and ZP3, all of which have a ZP polymerization domain that directs protein fibril formation and assembly into the three-dimensional ZP matrix. Egg coats surrounding oocytes in nonmammalian vertebrates and in invertebrates are also fibrillar matrices and are composed of ZP domain-containing proteins suggesting the basic structure and function of the ZP/egg coat is highly conserved. However, sequence similarity between ZP domains is low across species and thus the mechanism for the conservation of ZP/egg coat structure and its function is not known. Using approaches classically used to identify amyloid including conformation-dependent antibodies and dyes, X-ray diffraction, and negative stain electron microscopy, our studies suggest the mouse ZP is a functional amyloid. Amyloids are cross-? sheet fibrillar structures that, while typically associated with neurodegenerative and prion diseases in mammals, can also carry out functional roles in normal cells without resulting pathology. An analysis of the ZP domain from mouse ZP3 and ZP3 homologs from five additional taxa using the algorithm AmylPred 2 to identify amyloidogenic sites, revealed in all taxa a remarkable conservation of regions that were predicted to form amyloid. This included a conserved amyloidogenic region that localized to a stretch of hydrophobic amino acids previously shown in mouse ZP3 to be essential for fibril assembly. Similarly, a domain in the yeast protein ?-agglutinin/Sag 1p, that possesses ZP domain-like features and which is essential for mating, also had sites that were predicted to be amyloidogenic including a hydrophobic stretch that appeared analogous to the critical site in mouse ZP3. Together, these studies suggest that amyloidogenesis may be a conserved mechanism for ZP structure and function across billions of years of evolution. PMID:26043223

  17. Organization of projections of the zona incerta of the diencephalon to pallidal structures in the dog brain.

    PubMed

    Gorbachevskaya, A I

    2010-01-01

    Detailed studies of the organization of individual sectors in the zona incerta of the diencephalon to functionally diverse pallidal structures in the dog brain were performed by antero- and retrograde axon transport of horseradish peroxidase. The results showed that neurons in the caudal sector of the zona incerta innervate the globus pallidus and entopeduncular nucleus, which receive more extensive innervation from motor structures. The same pallidal structures receive projections from occasional neurons in the dorsal and causal sectors of the zona incerta. No connections of the zona incerta with the limbic ventral pallidum were found. PMID:20012212

  18. Penetration in vitro of zona-free pig oocytes by homologous and heterologous spermatozoa.

    PubMed

    Zhao, Xian-Mian; Songa, Xue-Xiong; Kawai, Yasuhiro; Niwa, Koji

    2002-09-01

    We examined the penetrability of pig, rat and bull spermatozoa into zona-free pig oocytes. Frozen-thawed boar spermatozoa penetrated into both zona-intact and zona-free oocytes with similar efficacy in a modified Tris-buffered medium (mTBM) supplemented with BSA and caffeine, but not in medium without caffeine. Rat epididymal spermatozoa did not readily penetrate into zona-free pig oocytes in mTBM with BSA. However, when a modified Krebs-Ringer bicarbonate solution was used, penetration rate varied with sperm concentrations at insemination: 79% of the oocytes were penetrated at 1.0 x 10(6) cells/ml, but very few at 0.1 x 10(6) and 10.0 x 10(6) cells/ml. In all oocytes penetrated, no activation was observed and the sperm nucleus was fully decondensed but did not transform into a male pronucleus. Frozen-thawed bull spermatozoa were also found to penetrate into zona-free pig oocytes in mTBM with BSA, caffeine and heparin: higher penetration rates were obtained with 1.0 x 106 and 10.0 x 10(6) spermatozoa/ml compared with 0.1 x 10(6) spermatozoa/ml. The penetration rate with 1.0 x 10(6) spermatozoa/ml was stable in five different bulls. All oocytes penetrated were activated and male pronuclear formation was observed in 57-79% of the penetrated oocytes. These results suggest that capacitation or the acrosome reaction is required for boar, rat, and possibly, bull spermatozoa to penetrate into zona-free pig oocytes. Bull spermatozoa can easily induce activation of pig oocytes and form male pronuclei, but rat spermatozoa cannot do so, indicating species differences in the ability of spermatozoa to activate pig oocytes and to transform to male pronuclei in the ooplasm. PMID:12212897

  19. Effect of IVF and laser zona dissection on DNA methylation pattern of mouse zygotes

    E-print Network

    Rodenacker, Karsten

    2009 Ó Springer Science+Business Media, LLC 2009 Abstract In vitro fertilization (IVF) and zona fertilized in vitro with freshly collected spermatozoa. Zygotes were fixed 5, 8, and 12 h after fertilization spermatozoa and in vitro fertilization or thawed embryos and embryo transfer (Marschall et al. 1999). In vitro

  20. Event-driven dynamics of rigid bodies interacting via discretized potentials Ramses van Zona

    E-print Network

    Schofield, Jeremy

    Event-driven dynamics of rigid bodies interacting via discretized potentials Ramses van Zona A framework for performing event-driven, adaptive time step simulations of systems of rigid bodies interacting that effectively determines the times at which interaction energies change. As in most event-driven approaches

  1. Ecologa y Monitoreo del Lagarto Americano para el Plan Comprensivo de la Restauracin de los

    E-print Network

    Mazzotti, Frank

    aguas y de desarrollo en la Florida del Sur han reducido la cantidad y calidad de estos hábitats. Menor pantanos de agua dulce y estuarios de manglar. Casi todos los seres acuáticos en los Everglades se ven cantidad de agua dulce fluye hacia las zonas de manglares, lo que resulta en una mayor salinidad y en la

  2. ADRENIC ACID METABOLITES AS ENDOGENOUS ENDOTHELIUM- AND ZONA GLOMERULOSA-DERIVED HYPERPOLARIZING FACTORS

    PubMed Central

    Kopf, Phillip G.; Zhang, David X.; Gauthier, Kathryn M.; Nithipatikom, Kasem; Falck, John R.; Campbell, William B.

    2010-01-01

    Adrenic acid (docosatetraenoic acid), an abundant fatty acid in the adrenal gland, is identical to arachidonic acid except for two additional carbons on the carboxyl end. Adrenic acid is metabolized by cycloxygenases, cytochrome P450s, and lipoxygenases; however, little is known regarding the role of adrenic acid and its metabolites in vascular tone. Due to its abundance in the adrenal gland, we investigated the role of adrenic acid in vascular tone of bovine adrenal cortical arteries and its metabolism by bovine adrenal zona glomerulosa cells. In adrenal cortical arteries, adrenic acid caused concentration-dependent relaxations, which were inhibited by the epoxyeicosatrienoic acid antagonist 14,15-epoxyeicosa-5(Z)-enoic acid and the cytochrome 450 inhibitor SKF-525A. The large-conductance calcium-activated potassium channel channel blocker iberiotoxin or removal of the endothelium abolished these relaxations. Reverse-phase high-pressure liquid chromatography and liquid chromatography/mass spectrometry isolated and identified numerous adrenic acid metabolites from zona glomerulosa cells including dihomo-epoxyeicosatrienoic acids and dihomo-prostaglandins. In denuded adrenal cortical arteries, adrenic acid caused concentration-dependent relaxations in the presence of zona glomerulosa cells but not in their absence. These relaxations were inhibited by SKF-525A, 14,15-epoxyeicosa-5(Z)-enoic acid, and iberiotoxin. Dihomo-16,17-epoxyeicosatrienoic acid caused concentration-dependent relaxations of adrenal cortical arteries, which were inhibited by 14,15-epoxyeicosa-5(Z)-enoic acid and high potassium. Our results suggest that adrenic acid relaxations of bovine adrenal cortical arteries are mediated by endothelial and zona glomerulosa cell cytochrome P450 metabolites. Thus, adrenic acid metabolites could function as endogenous endothelium- and zona glomerulosa-derived hyperpolarizing factors in the adrenal cortex and contribute to the regulation of adrenal blood flow. PMID:20038752

  3. Effects of human menopausal gonadotropin on zona pellucida and pregnancy outcomes of ovarian stimulation protocols

    PubMed Central

    He, Bing; Junping, Cheng; Li, Huang; Weihong, Tan; Lintao, Xue; Shikai, Wang

    2015-01-01

    Background: Human menopausal gonadotropin (hMG) has contributed many improvements to human assisted reproduction. However, effects of hMG on oocyte development and clinical results remain controversial. Objective: This study was conducted to investigate the effects of hMG on the zona pellucida of oocytes, as well as clinical results in superovulation treatment. Materials and Methods: This retrospective study was performed with 150 cycles of long-protocol treatment using recombinant follicle-stimulating hormone (r-FSH) with or without hMG. The number of retrieved oocytes, fertilization rate, implantation rate, pregnancy rate, and birefringence and thickness of the zona pellucida of oocytes were investigated. Results: No significant differences were existed in r-FSH +hMG, and r-FSH groups in the number of retrieved oocytes (11.99±0.75 vs. 13.9±0.73, p=0.06), maturation rate (84.76% vs. 83.32%, p=0.42), pregnancy rate (37.31% vs. 37.66%, p=0.96), and embryo implantation rate (28.97% vs. 23.26%, p=0.30). However, fertilization rate (82.95% vs. 78.75%; p=0.02) was different. Zona pellucida birefringence was lower in the r-FSH +hMG group than in the r-FSH group (6.70±0.50 vs. 7.04±0.31; p=0.53). Thickness values of the metaphase-II zona pellucida of the r-FSH +hMG group on the first (19.20±0.14 vs. 18.75±0.10; p=0.01) and second (18.69±0.12 vs. 18.17±0.14; p=0.00) days of insemination were both higher than those of the r-FSH group. Conclusion: hMG positively influenced the improvement of oocyte fertilization, as well as the birefringence and thickness of zona pellucida. PMID:26330847

  4. Digitalización de diapositivas del Sol en H ?

    NASA Astrophysics Data System (ADS)

    Missio, H.; Montenegro, C.; Montenegro, R.

    El objetivo de este trabajo ha sido el de obtener imágenes digitalizadas de las diapositivas tomadas del Sol en luz de hidrógeno de la línea correspondiente a H?, y de esta manera llegar a convertir las mismas a un archivo digital para poder ser tratadas luego por computadora y poder contabilizar con exactitud, mediante un programa adecuado para tal fin, las zonas activas del Sol en la imagen digitalizada. En principio, para llegar a esto se pensó en la utilización de medios accesibles, y como detector se utilizó un fototransistor ubicado dentro de un soporte rectangular sobre dos ejes de desplazamiento X e Y. Se han obtenido con este procedimiento imágenes de buena calidad, construídas a partir de tres datos digitalizados en cada barrido que aportan la posición X e Y y la intensidad del pixel en ese punto indicada en 255 tonos de grises.

  5. Fractured zona oocytes in in-vitro fertilization cycles stimulated with gonadotrophin-releasing hormone analogue and human menopausal gonadotrophin.

    PubMed

    Cordeiro, I; Calhaz-Jorge, C; Leal, F; Barata, M; Coelho, A P

    1993-04-01

    In order to assess the possible influence of gonadotrophin-releasing hormone analogue and human menopausal gonadotrophin on the occurrence of fractured zona oocytes (FZOs) in in-vitro fertilization (IVF) treatment cycles, we analysed 267 consecutive cycles in 199 patients. In 87 cycles, at least one fractured zona oocyte was recovered, and in 180 cycles only intact zona oocytes (IZOs) were recovered. FZOs represented 5.8% of all oocytes retrieved and 14.8% when only cycles with FZOs were considered. Serum oestradiol concentrations were significantly higher at day -3 and day -2 (P < 0.02) in cycles yielding at least one fractured zona oocyte compared to IZO cycles (day 0 = retrieval day), and there was a higher incidence of G terminal pattern of oestradiol curve (P < 0.01) in cycles with FZOs. The mean numbers of all oocytes retrieved and of mature oocytes were significantly higher in FZO than in IZO cycles (P < 0.001). The fertilization rate of mature oocytes was significantly reduced (P < 0.05) in cycles with one or more oocytes with fractured zonae. There was no significant difference in the number of embryos transferred, pregnancy and abortion rates in both groups. We conclude that although the occurrence of fractured zona oocytes is a frequent event, it does not affect the overall results of our IVF programme. Zona pellucida fragility may be the result of over-maturation of some oocytes. PMID:8501194

  6. Most fertilizing mouse spermatozoa begin their acrosome reaction before contact with the zona pellucida during in vitro fertilization

    PubMed Central

    Jin, Mayuko; Fujiwara, Eiji; Kakiuchi, Yasutaka; Okabe, Masaru; Satouh, Yuhkoh; Baba, Shoji A.; Chiba, Kazuyoshi; Hirohashi, Noritaka

    2011-01-01

    To fuse with oocytes, spermatozoa of eutherian mammals must pass through extracellular coats, the cumulus cell layer, and the zona pellucida (ZP). It is generally believed that the acrosome reaction (AR) of spermatozoa, essential for zona penetration and fusion with oocytes, is triggered by sperm contact with the zona pellucida. Therefore, in most previous studies of sperm–oocyte interactions in the mouse, the cumulus has been removed before insemination to facilitate the examination of sperm–zona interactions. We used transgenic mouse spermatozoa, which enabled us to detect the onset of the acrosome reaction using fluorescence microscopy. We found that the spermatozoa that began the acrosome reaction before reaching the zona were able to penetrate the zona and fused with the oocyte's plasma membrane. In fact, most fertilizing spermatozoa underwent the acrosome reaction before reaching the zona pellucida of cumulus-enclosed oocytes, at least under the experimental conditions we used. The incidence of in vitro fertilization of cumulus-free oocytes was increased by coincubating oocytes with cumulus cells, suggesting an important role for cumulus cells and their matrix in natural fertilization. PMID:21383182

  7. Fish zona radiata (eggshell) protein: a sensitive biomarker for environmental estrogens.

    PubMed Central

    Arukwe, A; Knudsen, F R; Goksøyr, A

    1997-01-01

    Environmental estrogens have recently caused great concern because of their ability to mimic natural hormones and influence vital endocrine functions in humans and wildlife. The induction of vitellogenin (Vtg) synthesis by environmental estrogens in viviparous vertebrates has been proposed as an effective and sensitive biomarker of estrogenicity. Immunochemical analysis of plasma from Atlantic salmon (Salmo salar) exposed to 4-nonylphenol (NP) or to effluent from oil refinery treatment plant (ORTP), shows that NP and ORTP effluent induces Vtg and zona radiata proteins (Zrp) in a dose-dependent manner. However, Zrp-beta cross-reactive proteins are more responsive than Zrp-alpha, Zrp-gamma, and Vtg. The sensitivity of Zrp induction points to the zona radiata proteins as alternate biomarkers of estrogenicity. Images Figure 1. A Figure 1. B Figure 2. Figure 3. A Figure 3. B Figure 4. A Figure 4. B Figure 5. PMID:9189707

  8. Thermal effects in laser-assisted pre-embryo zona drilling

    NASA Astrophysics Data System (ADS)

    Douglas-Hamilton, Diarmaid H.; Conia, Jerome D.

    2001-04-01

    Diode lasers ((lambda) equals 1480 nm) are used with in vitro fertilization to dissect the zone pellucida (shell) of pre- embryos. A focused laser beam is applied in vitro to form a channel or trench in the zona pellucida. The procedure is used to facilitate biopsy or as a promoter of embryo hatching. We present examples and measurements of zona pellucida ablation using animal models. In using the laser it is vital not to damage pre-embryo cells, e.g., by overheating. In order to define safe regimes we have derived some thermal side effects of zona pellucida removal. The temperature profile in the beam and vicinity is predicted as function of laser pulse duration and power. In a crossed- beam experiment a HeNe laser probe is used to detect the temperature-induced change in the refractive index of an aqueous solution, and estimate local thermal gradient. We find that the diode laser beam produces superheated water approaching 200 degree(s)C on the beam axis. Thermal histories during and following the laser pulse are given for regions in the neighborhood of the beam. We conclude that an optimum regime exists with pulse duration

  9. The zona pellucida of the koala (Phascolarctos cinereus): its morphogenesis and thickness

    PubMed Central

    Chapman, Jamie A; Leigh, Christopher M; Breed, William G

    2006-01-01

    In this study the ultrastructural organization of the koala oocyte and the thickness of the surrounding extracellular coat, the zona pellucida, has been determined to ascertain whether there is coevolution of the morphology of the female gamete with that of the highly divergent male gamete that is found in this marsupial species. Ovaries from several adult koalas were obtained and prepared for transmission electron microscopy. Oocytes in large tertiary follicles were somewhat smaller than those of most other marsupials, although their ultrastructural organization appeared similar and included many yolk vesicles. The zona pellucida surrounding the oocytes in tertiary follicles was approximately 8 µm thick and thus is of similar thickness to that of some eutherian mammals but at least twice as thick as that of most marsupial species so far studied. The results indicate that the koala oocyte is unusually small for a marsupial species whereas the zona pellucida is, by contrast, much thicker. How this relates to sperm–egg interaction at the time of fertilization has yet to be determined. PMID:16928207

  10. Degradación de Marismas Costera: el Impacto de la Eutrofización en la Supervivencia del las Marismas Costeras en New England y Central California, USA. (Salt Marsh Deterioration in New England and Central California: Impacts of Eutrophication on Salt Marsh Survival.)

    EPA Science Inventory

    Las marismas costeras proporcionan numerosos beneficios a los ecosistemas, incluyendo la proporción del hábitat de la flora y fauna, la protección de las zonas costeras contra inundaciones durante eventos extremos, mejoran la calidad del agua para las almejas y ostras a través de...

  11. Sperm Proteasomes Degrade Sperm Receptor on the Egg Zona Pellucida during Mammalian Fertilization

    PubMed Central

    Zimmerman, Shawn W.; Manandhar, Gaurishankar; Yi, Young-Joo; Gupta, Satish K.; Sutovsky, Miriam; Odhiambo, John F.; Powell, Michael D.; Miller, David J.; Sutovsky, Peter

    2011-01-01

    Despite decades of research, the mechanism by which the fertilizing spermatozoon penetrates the mammalian vitelline membrane, the zona pellucida (ZP) remains one of the unexplained fundamental events of human/mammalian development. Evidence has been accumulating in support of the 26S proteasome as a candidate for echinoderm, ascidian and mammalian egg coat lysin. Monitoring ZP protein degradation by sperm during fertilization is nearly impossible because those few spermatozoa that penetrate the ZP leave behind a virtually untraceable residue of degraded proteins. We have overcome this hurdle by designing an experimentally consistent in vitro system in which live boar spermatozoa are co-incubated with ZP-proteins (ZPP) solubilized from porcine oocytes. Using this assay, mimicking sperm-egg interactions, we demonstrate that the sperm-borne proteasomes can degrade the sperm receptor protein ZPC. Upon coincubation with motile spermatozoa, the solubilized ZPP, which appear to be ubiquitinated, adhered to sperm acrosomal caps and induced acrosomal exocytosis/formation of the acrosomal shroud. The degradation of the sperm receptor protein ZPC was assessed by Western blotting band-densitometry and proteomics. A nearly identical pattern of sperm receptor degradation, evident already within the first 5 min of coincubation, was observed when the spermatozoa were replaced with the isolated, enzymatically active, sperm-derived proteasomes. ZPC degradation was blocked by proteasomal inhibitors and accelerated by ubiquitin-aldehyde(UBAL), a modified ubiquitin protein that stimulates proteasomal proteolysis. Such a degradation pattern of ZPC is consistent with in vitro fertilization studies, in which proteasomal inhibitors completely blocked fertilization, and UBAL increased fertilization and polyspermy rates. Preincubation of intact zona-enclosed ova with isolated active sperm proteasomes caused digestion, abrasions and loosening of the exposed zonae, and significantly reduced the fertilization/polyspermy rates after IVF, accompanied by en-mass detachment of zona bound sperm. Thus, the sperm borne 26S proteasome is a candidate zona lysin in mammals. This new paradigm has implications for contraception and assisted reproductive technologies in humans, as well as animals. PMID:21383844

  12. Simplification of bovine somatic cell nuclear transfer by application of a zona-free manipulation technique.

    PubMed

    Booth, P J; Tan, S J; Reipurth, R; Holm, P; Callesen, H

    2001-01-01

    Contemporary nuclear transfer techniques often require the involvement of skilled personnel and extended periods of micromanipulation. Here, we present details of the development of a nuclear transfer technique for somatic cells that is both simpler and faster than traditional methods. The technique comprises the bisection of zona-free oocytes and the reconstruction of embryos comprising two half cytoplasts and a somatic cell by adherence using phytohaemagglutinin-P (PHA) followed by an electropulse and subsequent culture in microwells (termed WOWs--well of the well). The development of the system was based on results using parthenogenetic and in vitro fertilized zygotes in order to (a) select the optimal primary activation agent that induced the lowest lysis rate but highest parthenogenetic blastocyst yield, (b) evaluate the quantity and quality of zona-free blastocysts produced in WOWs, and (c) establish any potential embryotoxic effects of PHA-P. The initial data indicated that, of calcium ionophore A23187, ionomycin, and electropulse treatments as primary activation agents, the two former were equally efficient even with reduced exposure times. WOW-culture of zona-free versus zona-intact zygotes were not different in either blastocyst yield (44.6 +/- 2.4% versus 51.8 +/- 13.5% [mean +/- SEM]) or quality (126.3 +/- 48.4 versus 119.9 +/- 32.6 total cells), and exposure of zygotes to PHA-P did not reduce blastocyst yields compared to vehicle control (40.8 +/- 11.6% versus 47.1 +/- 20.8% of cultured oocytes). Subsequent application of the optimized technique for nuclear transfer using nine different granulosa cell primary cultures (cultured in 0.5% serum for 5-12 days) generated 37.6 +/- 3.9% (11 replicates; range, 16.4-58.1%) blastocysts per successfully fused and surviving reconstructed embryo (after activation), and 33.6 +/- 3.7% blastocysts per attempted reconstructed embryo. Mean day 7 total blastocyst cell numbers from 5 clone families was 128.1 +/- 15.3. The ongoing pregnancy rate of recipients each receiving two nuclear transfer blastocysts is 3/13 (23.1%) recipients pregnant at 5 months after transfer. These results suggest that the zona-free nuclear transfer technique generates blastocysts of equivalent quantity and quality compared to conventional micromanipulation methods, requires less technical expertise, is less time consuming and can double the daily output of reconstructed embryos (even after taking into consideration the rejection of the half oocytes containing the metaphase plate). PMID:11945223

  13. Laser-assisted zona pellucida thinning does not facilitate hatching and may disrupt the in vitro hatching process: a morphokinetic study in the mouse

    PubMed Central

    Schimmel, Tim; Cohen, Jacques; Saunders, Helen; Alikani, Mina

    2014-01-01

    STUDY QUESTION Does laser-assisted zona thinning of cleavage stage mouse embryos facilitate hatching in vitro? SUMMARY ANSWER No, unlike laser zona opening, zona thinning does not facilitate embryo hatching. WHAT IS KNOWN ALREADY Artificial opening of the zona pellucida facilitates hatching of mouse and human embryos. Laser-assisted zona thinning has also been used for the purpose of assisted hatching of human embryos but it has not been properly investigated in an animal model; thinning methods have produced inconsistent clinical results. STUDY DESIGN, SIZE, DURATION Time-lapse microscopy was used to study the hatching process in the mouse after zona opening and zona thinning; a control group of embryos was not zona-manipulated but exposed to the same laser energy. PARTICIPANTS/MATERIALS, SETTING, METHODS Eight-cell CB6F1/J mouse embryos were pooled and allocated to three groups (n = 56 per group): A control group of embryos that were exposed to a dose of laser energy focused outside the zona pellucida (zona intact); one experimental group of embryos in which the zona pellucida was opened by complete ablation using the same total number of pulses as the control group; a second experimental group of embryos in which the zona pellucida was thinned to establish a smooth lased area using the same number of pulses as used in the other two groups. The width of the zona opening was 25 ?m and width of the thinned area was 35 ?m. Development was monitored by time-lapse microscopy. Overall treatment differences for continuous variables were analyzed by analysis of variance and pairwise comparisons using the Student t-test allowing for unequal variances, while for categorical data, a standard chi-squared test was utilized for all pairwise comparisons. MAIN RESULTS AND THE ROLE OF CHANCE The frequency of complete hatching was 33.9% in the control group, 94.4% after zona opening, and 39.3% after zona thinning (overall group comparison, P < 0.0001). Overall, 60.7% of the zona-thinned embryos did not complete the hatching process and remained trapped within the zona; when they did hatch, they did not necessarily hatch from the zona-thinned area. Hatching in about one-third of the zona-intact embryos began with breaches at multiple sites by small groups of cells. Likewise, 53.6% of zona-thinned embryos had multiple breaches, always involving an area outside the thinned zone. Zona opening decreased multiple breaching and led to blastocyst escape an average of 14 h earlier than zona-thinned embryos and 5.5 h before control embryos (P = 0.0003). LIMITATIONS, REASONS FOR CAUTION The experiments presented here were limited to in vitro experiments performed in the mouse. Whether human embryos would behave the same way under similar circumstances is unknown. We postulate that zona thinning is not beneficial in human embryos. WIDER IMPLICATIONS OF THE FINDINGS The experiments demonstrate that zona thinning is not equivalent to zona opening for assisted hatching. The study provides reason for systematic reviews of assisted hatching trials to take the method of assisted hatching into consideration and not combine the results of zona thinning and zona opening procedures. STUDY FUNDING/COMPETING INTEREST(S) Institutional funds were used for the study. No competing interests are declared. PMID:25267786

  14. El uso de la neuromodulación para el tratamiento del temblor

    PubMed Central

    Bendersky, Damián; Ajler, Pablo; Yampolsky, Claudio

    2014-01-01

    Introducción: El temblor puede ser un desorden incapacitante y el tratamiento de primera línea para estos pacientes es farmacológico. Sin embargo, este tratamiento puede llevar a una reducción satisfactoria del temblor en sólo el 50% de los pacientes con temblor esencial. La talamotomía era el tratamiento de elección para el temblor refractario al tratamiento médico hasta que comenzó a utilizarse la estimulación cerebral profunda (ECP) del núcleo ventral intermedio (Vim) del tálamo. En la actualidad, raramente se realiza la talamotomía. Métodos: Este artículo es una revisión no sistemática de las indicaciones, resultados, parámetros de programación y técnica quirúrgica de la ECP del Vim para el tratamiento del temblor. Resultados: Aunque los resultados clínicos son similares usando la talamotomía o la ECP del Vim, la primera causa más efectos adversos que la última. Además, la ECP puede ser usada bilateralmente, mientras que la talamotomía tiene un alto riesgo de causar disartria cuando se realiza de ambos lados. La ECP del Vim logró una adecuada mejoría del temblor en varias series de pacientes con temblor causado por temblor esencial, enfermedad de Parkinson o esclerosis múltiple. Además del Vim, hay otros blancos que están siendo usados por varios autores, tales como la zona incerta y las radiaciones prelemniscales. Conclusión: La ECP del Vim es un tratamiento útil para el temblor incapacitante refractario al tratamiento médico. Es esencial realizar una precisa selección de pacientes, así como utilizar una técnica quirúrgica correcta. Aún se desconoce el mejor blanco estereotáctico para el temblor, aunque el Vim es el más usado. PMID:25165613

  15. Evidence of elastic to plastic transition in the zona pellucida of oocytes using atomic force spectroscopy

    NASA Astrophysics Data System (ADS)

    Papi, Massimiliano; Sylla, Lakamy; Parasassi, Tiziana; Brunelli, Roberto; Monaci, Maurizio; Maulucci, Giuseppe; Missori, Mauro; Arcovito, Giuseppe; Ursini, Fulvio; De Spirito, Marco

    2009-04-01

    We have investigated the mechanical properties of the zona pellucida (ZP), a multilayer glycoprotein coat that surrounds mammalian eggs, using atomic force spectroscopy. The response of the membrane to mechanical stress has been reconstructed using a modified Hertz model. The transition from elastic behavior, which occurs when low stress forces are applied (characterized by a Young's modulus E =(22±5) kPa), toward plastic behavior is observed. The critical indentation necessary to induce plastic deformations occurs at ?yield=(550±50) nm. This high critical value, corresponding to two ZP layers, well supports the noncovalent long lifetimes of interactions that take place between constituent glycoproteins.

  16. Projections of the basal ganglia to the zona incerta of the dog diencephalon.

    PubMed

    Chivileva, O G; Gorbachevskaya, A I

    2008-09-01

    Retrograde axonal transport of horseradish peroxidase was used to show that the projections of the globus pallidus, entopeduncular nucleus, substantia nigra, and pedunculopontine tegmental nucleus in dogs are directed to all segments of the zone incerta. The experiments reported here identified no topical features in the organization of these projections in dogs, as application of marker to different areas of the zona incerta yielded similar distributions of labeled neurons in the basal ganglia. No striatal projections to the zone incerta were found. PMID:18709459

  17. Imaging the zona pellucida of canine and feline oocytes using scanning electron microscopy.

    PubMed

    Lunn, Matthew O; Wright, Shirley J

    2009-02-01

    Ultrastructure of the zona pellucida (ZP) of canine and feline oocytes has not been fully investigated. The objective of the study was to evaluate the potential use of the low vacuum scanning electron microscope (LVSEM) with oocytes. This required development of a method to prepare canine and feline cumulus-oocyte complexes (COCs) for LVSEM to provide ultrastructural information on the ZP. COCs were collected from ovaries, and cumulus cells were either partially or completely removed to reveal the ZP. COCs and zona-intact oocytes were fixed at 4 degrees C for 1 h in 2.5% glutaraldehyde in 0.1 M sodium cacodylate buffer, pH 7.4 and subsequently viewed wet or further processed by critical point drying, and viewed uncoated or sputter coated with gold. Although the spongy surface of the ZP was visible at low vacuum in uncoated oocytes, coated oocytes had more details at high vacuum. The ZP surface of canine and feline oocytes contained numerous various-sized, spherical or elliptical pores that narrowed centripetally splitting into several smaller, deep pores. The round to oblong cumulus cells tightly surrounded the ZP. Each corona radiata cumulus cell tapered into a thin projection that entered the ZP. Our detailed techniques will enable future studies connecting ultrastructural and molecular aspects of oocyte maturation and development in mammals. PMID:19144252

  18. Structural Analysis of Peptide-Analogues of Human Zona Pellucida ZP1 Protein with Amyloidogenic Properties: Insights into Mammalian Zona Pellucida Formation

    PubMed Central

    Louros, Nikolaos N.; Iconomidou, Vassiliki A.; Giannelou, Polina; Hamodrakas, Stavros J.

    2013-01-01

    Zona pellucida (ZP) is an extracellular matrix surrounding and protecting mammalian and fish oocytes, which is responsible for sperm binding. Mammalian ZP consists of three to four glycoproteins, called ZP1, ZP2, ZP3, ZP4. These proteins polymerize into long interconnected filaments, through a common structural unit, known as the ZP domain, which consists of two domains, ZP-N and ZP-C. ZP is related in function to silkmoth chorion and in an evolutionary fashion to the teleostean fish chorion, also fibrous structures protecting the oocyte and embryo, that both have been proven to be functional amyloids. Two peptides were predicted as ‘aggregation-prone’ by our prediction tool, AMYLPRED, from the sequence of the human ZP1-N domain. Here, we present results from transmission electron microscopy, X-ray diffraction, Congo red staining and attenuated total reflectance Fourier-transform infrared spectroscopy (ATR FT-IR), of two synthetic peptide-analogues of these predicted ‘aggregation-prone’ parts of the human ZP1-N domain, that we consider crucial for ZP protein polymerization, showing that they both self-assemble into amyloid-like fibrils. Based on our experimental data, we propose that human ZP (hZP) might be considered as a novel, putative, natural protective amyloid, in close analogy to silkmoth and teleostean fish chorions. Experiments are in progress to verify this proposal. We also attempt to provide insights into ZP formation, proposing a possible model for hZP1-N domain polymerization. PMID:24069181

  19. Specific antibodies to porcine zona pellucida detected by quantitative radioimmunoassay in both fertile and infertile women

    SciTech Connect

    Kurachi, H.; Wakimoto, H.; Sakumoto, T.; Aono, T.; Kurachi, K.

    1984-02-01

    The specific radioimmunoassay system was developed for the titration of the antibodies to porcine zona pellucida (ZP) in human sera by using /sup 125/I-labeled purified porcine ZP as antigen, which is known to have cross-reactivity with human ZP. The antibodies in human sera were detected in 3 of 11 (27%) women with unexplained infertility, in 16 of 48 (33%) amenorrheic patients, in 4 of 12 (33%) fertile women, and in 3 of 10 (30%) men. Moreover, antibody titers in infertile women were no higher than those in fertile women and in men. These results seem to suggest that the antibodies in human sera that cross-react with porcine ZP may not be an important factor in causing infertility in women.

  20. A GABAergic projection from the zona incerta to cortex promotes cortical neuron development.

    PubMed

    Chen, Jiadong; Kriegstein, Arnold R

    2015-10-30

    ?-Aminobutyric acid (GABA) is the major inhibitory transmitter in the mature brain but is excitatory in the developing cortex. We found that mouse zona incerta (ZI) projection neurons form a GABAergic axon plexus in neonatal cortical layer 1, making synapses with neurons in both deep and superficial layers. A similar depolarizing GABAergic plexus exists in the developing human cortex. Selectively silencing mouse ZI GABAergic neurons at birth decreased synaptic activity and apical dendritic complexity of cortical neurons. The ZI GABAergic projection becomes inhibitory with maturation and can block epileptiform activity in the adult brain. These data reveal an early-developing GABAergic projection from the ZI to cortical layer 1 that is essential for proper development of cortical neurons and balances excitation with inhibition in the adult cortex. PMID:26429884

  1. Tiger, Bengal and Domestic Cat Embryos Produced by Homospecific and Interspecific Zona-Free Nuclear Transfer.

    PubMed

    Moro, L N; Jarazo, J; Buemo, C; Hiriart, M I; Sestelo, A; Salamone, D F

    2015-10-01

    The aim of this study was to evaluate three different cloning strategies in the domestic cat (Felis silvestris) and to use the most efficient to generate wild felid embryos by interspecific cloning (iSCNT) using Bengal (a hybrid formed by the cross of Felis silvestris and Prionailurus bengalensis) and tiger (Panthera tigris) donor cells. In experiment 1, zona-free (ZP-free) cloning resulted in higher fusion and expanded blastocyst rates with respect to zona included cloning techniques that involved fusion or injection of the donor cell. In experiment 2, ZP-free iSCNT and embryo aggregation (2X) were assessed. Division velocity and blastocyst rates were increased by embryo aggregation in the three species. Despite fewer tiger embryos than Bengal and cat embryos reached the blastocyst stage, Tiger 2X group increased the percentage of blastocysts with respect to Tiger 1X group (3.2% vs 12.1%, respectively). Moreover, blastocyst cell number was almost duplicated in aggregated embryos with respect to non-aggregated ones within Bengal and tiger groups (278.3 ± 61.9 vs 516.8 ± 103.6 for Bengal 1X and Bengal 2X groups, respectively; 41 vs 220 ± 60 for Tiger 1X and Tiger 2X groups, respectively). OCT4 analysis also revealed that tiger blastocysts had higher proportion of OCT4-positive cells with respect to Bengal blastocysts and cat intracytoplasmic sperm injection blastocysts. In conclusion, ZP-free cloning has improved the quality of cat embryos with respect to the other cloning techniques evaluated and was successfully applied in iSCNT complemented with embryo aggregation. PMID:26332056

  2. INDUCTION OF ZONA RADIATA PROTEINS AND VITELLOGENINS IN ESTRADIOL AND NONYLPHENOL EXPOSED MALE SHEEPSHEAD MINNOWS (CYPRINODON VARIEGATUS)

    EPA Science Inventory

    Knoebl, Iris, Michael J. Hemmer and Nancy D. Denslow. 2004. Induction of Zona Radiata Proteins and Vitellogenins in Estradiol and Nonylphenol Exposed Male Sheepshead Minnows (Cyprinodon variegatus). Mar. Environ. Res. 58(2-5):547-551. (ERL,GB X1059).

    Several genes normall...

  3. Pitch Variability in Patients with Parkinson's Disease: Effects of Deep Brain Stimulation of Caudal Zona Incerta and Subthalamic Nucleus

    ERIC Educational Resources Information Center

    Karlsson, Fredrik; Olofsson, Katarina; Blomstedt, Patric; Linder, Jan; van Doorn, Jan

    2013-01-01

    Purpose: The purpose of the present study was to examine the effect of deep brain stimulation (DBS) of the subthalamic nucleus (STN) and the caudal zona incerta (cZi) pitch characteristics of connected speech in patients with Parkinson's disease (PD). Method: The authors evaluated 16 patients preoperatively and 12 months after DBS surgery. Eight…

  4. Biochem. J. (1996) 320, 10171023 (Printed in Great Britain) 1017 Progesterone and the zona pellucida activate different transducing pathways

    E-print Network

    Museo Nacional de Ciencias Naturales

    1996-01-01

    , -aminobutyric acid; GABAA, GABA type A; ZRK, zona receptor kinase. * To whom correspondence should be addressed a -aminobutyric acid (GABA) type A (GABAA )-like receptor. Transducing mechanisms coupled to this receptor were activated by oocyte-associated agonists. (GABAA )-like receptor with Cl- channel activity [6

  5. Male Marmoset Monkeys Express an Adrenal Fetal Zone at Birth, But Not a Zona Reticularis in Adulthood

    E-print Network

    Saltzman, Wendy

    Male Marmoset Monkeys Express an Adrenal Fetal Zone at Birth, But Not a Zona Reticularis monkeys produce DS at birth, but unlike humans and rhesus monkeys, do not produce comparable amounts to rhesus monkeys, but not cytb5. HPLC analysis revealed similar 17 -hydroxylase action on preg- nenolone

  6. Improved material point method for simulating the zona failure response in piezo-assisted intracytoplasmic sperm injection

    E-print Network

    Montgomery-Smith, Stephen

    -assisted intracytoplasmic sperm injection Yong Gan a , Zhen Chen a,b,* , Stephen Montgomery-Smith c a Department of Civil for the coupled CFD and CSD simulation of the zona failure response in piezo-assisted intracytoplasmic sperm­ Keywords: material point method; piezo-assisted intracytoplasmic sperm injection; shock-induced failure

  7. Descripción de la zona de alta difusión en un modelo bidimensional para hojas de corriente

    NASA Astrophysics Data System (ADS)

    Montero, M. F.; Paola, C. A.; Platzeck, A. M.

    Los modelos bidimensionales para describir hojas de corriente de alta simetría no suministran una descripción detallada de las regiones donde la difusión es considerablemente importante. Tal es el caso de los modelos desarrollados en la década del '60 por Sweet, Parker, Petschek y Sonnerup. En esta comunicación presentamos una solución de las ecuaciones MHD en el entorno del origen, construyendo series bidimensionales para todas las magnitudes físicas involucradas. Valiéndonos de la alta simetría y de las características del problema, logramos reducir el número de coeficientes a calcular. Utilizamos un programa autoconsistente para extender el cálculo a regiones vecinas con difusión moderada o despreciable.

  8. Boletín del Instituto Nacional del Cáncer

    Cancer.gov

    La edición electrónica del Boletín del Instituto Nacional del Cáncer se publicó mensualmente desde septiembre de 2009 hasta enero de 2013, con el objetivo de difundir información sobre la investigación del cáncer, tanto de estudios financiados por el NCI y otras dependencias federales, así como de investigaciones realizadas por instituciones en Estados Unidos y alrededor del mundo.

  9. Dicalcin, a zona pellucida protein that regulates fertilization competence of the egg coat in Xenopus laevis.

    PubMed

    Miwa, Naofumi

    2015-11-01

    Fertilization is a highly coordinated process whereby sperm interact with the egg-coating envelope (called the zona pellucida, ZP) in a taxon-restricted manner, Fertilization triggers the resumption of the cell cycle of the egg, ultimately leading to generation of a new organism that contains hereditary information of the parents. The complete sperm-ZP interaction comprises sperm recognition of the ZP, the acrosome reaction, penetration of the ZP, and fusion with the egg. Recent evidence suggests that these processes involve oligosaccharides associated with a ZP constituent (termed ZP protein), the polypeptide backbone of a ZP protein, and/or the proper three-dimensional filamentous structure of the ZP. However, a detailed description of the molecular mechanisms involved in sperm-ZP interaction remains elusive. Recently, I found that dicalcin, a novel ZP protein-associated protein, suppresses fertilization through its association with gp41, the frog counterpart of the mammalian ZPC protein. This review focuses on molecular aspects of sperm-ZP interaction and describes the fertilization-suppressive function of dicalcin and associated molecular mechanisms. The amount of dicalcin in the ZP significantly correlates with alteration of the lectin-staining pattern within the ZP and the orientation pattern of ZP filaments, which may assist in elucidating the complex molecular mechanisms that underlie sperm-ZP interaction. PMID:26420688

  10. Population genetic structure of Attalea vitrivir Zona (Arecaceae) in fragmented areas of southeast Brazil.

    PubMed

    Santos, R R M; Cavallari, M M; Pimenta, M A S; Abreu, A G; Costa, M R; Guedes, M L

    2015-01-01

    Attalea vitrivir Zona (synonym Orbignya oleifera) is one of the six species of Arecaceae known as "babassu". This species is used to make cosmetics, food, and detergents due to the high concentration of oil in the seeds. It is found only in fragmented areas of southern Bahia State and northern Minas Gerais State, southeast Brazil, and this fragmentation has affected both its ecological and genetic characteristics. We evaluated the genetic diversity and population genetic structure of A. vitrivir in six areas of two different regions at the extremes of its geographical range, in order to gain a better understanding of the factors that affect the distribution and partitioning of its diversity. Nine inter simple sequence repeat (ISSR) markers amplified 74 polymorphic bands, resulting in large diversity values (Shannon diversity index, 0.37-0.47; intrapopulation genetic diversity, 0.25-0.34). Analysis of molecular variance (AMOVA) revealed considerable differentiation between sampling sites (30.03%) and regions (12.08%), although most of the diversity was observed within sampling sites (69%). Further differentiation between sampling sites was noted more in the northern region than in the southern region, highlighting the genetic connectivity between the sampling sites within Rio Pandeiros Environmental Protection Area (southern region). The identification of two distinct genetic clusters (K = 2) corresponded to the northern and southern regions, and corroborated the AMOVA results. We suggest that the northern area, outside Rio Pandeiros Environmental Protection Area, must be included in future management plans for this species. PMID:26125852

  11. An evaluation of different media for the zona-free hamster egg penetration test.

    PubMed

    Mortimer, D

    1986-02-01

    Hypertonic high-salt Biggers, Whitten, and Whittingham medium was compared with either a complex culture medium (synthetic tubal fluid) or a variant of Tyrode's medium for capacitating donor human spermatozoa to be used in the zona-free hamster egg penetration test. Five sperm preparations showed a slightly higher penetration rate in synthetic tubal fluid than in high-salt Biggers, Whitten, and Whittingham medium, five showed equivalent results, and only two had slightly lower penetration rates. However, in modified Tyrode's medium only one sample showed a lower penetration, while six showed comparable results and five showed higher rates of penetration. This last group included two samples that had demonstrated zero penetration in high-salt Biggers, Whitten, and Whittingham medium. Although no overall significant differences between media in the two series of experiments could be discerned with paired t tests, in view of the lower incidence of false negative results in modified Tyrode's medium and the absence of osmotic stress, this medium may represent a better choice for routine performance of the hamster egg penetration test. PMID:3946522

  12. A hybrid characterization framework to determine the visco-hyperelastic properties of a porcine zona pellucida

    PubMed Central

    Boccaccio, A.; Lamberti, L.; Papi, M.; De Spirito, M.; Douet, C.; Goudet, G.; Pappalettere, C.

    2014-01-01

    The zona pellucida (ZP) is a specialized extracellular matrix surrounding the developing oocyte. This thick matrix consists of various types of glycoprotein that play different roles in the fertilization process. Nowadays, several techniques are available for assessing ZP's mechanical response. The basic assumption behind these methods is that the ZP behaves like an elastic body: hence, dissipative forces are neglected and Young's modulus remains unaffected by probe dynamics. However, dissipative forces are strongly regulated by the slippage of ZP chains past one another while reaction forces related to elastic deformations (driven by the ability of each chain to stretch) depend on the ZP structure (i.e. number of cross-links and distances between knots). Although viscous reaction forces generated by the ZP are one of the main factors regulating sperm transit, their peculiar behaviour along the ZP structure remains poorly understood and rarely investigated. In order to overcome this limitation, a novel visco-hyperelastic model describing the porcine ZP reaction forces generated by nanoindentations at different probe rates is developed and verified in this study. Visco-hyperelastic parameters of porcine ZP membranes are determined by means of a hybrid characterization framework combining atomic force microscopy nanoindentation measurements, nonlinear finite-element analysis and nonlinear optimization. Remarkably, it is possible to separate the contributions of hyperelastic and viscous terms to ZP mechanical response and evaluate the error made in the determination of ZP mechanical properties if viscous effects were not considered. PMID:24748956

  13. Evidence for extracellular, but not intracellular, generation of angiotensin II in the rat adrenal zona glomerulosa

    SciTech Connect

    Urata, H.; Khosla, M.C.; Bumpus, M.; Husain, A. )

    1988-11-01

    Based on the observation that high levels of renin and angiotensin II (Ang II) are found in the adrenal zona glomerulosa (ZG), it has been postulated that Ang II is formed intracellularly by the renin-converting enzyme cascade in this tissue. To test this hypothesis, the authors examined renin-angiotensin system components in subcellular fractions of the rat adrenal ZG. Renin activity and immunoreactive-Ang II (IR-Ang II) were observed in vesicular fractions but were not colocalized. In addition, angiotensinogen, angiotensin I, and converting enzyme were not observed in the renin or IR-Ang II-containing vesicular fractions. These data do not support the hypothesis that Ang II is formed intracellularly within the renin-containing vesicles of the ZG. Rather, since modulatable renin release from adrenal ZG slices was observed and renin activity was found in dense vesicular fractions (33-39% sucrose), it is likely that Ang II formation in the ZG is extracellular and initiated by the release of vesicular renin. In ZG lysomal fractions {sup 125}I-labeled Ang II was degraded to {sup 125}I-labeled des-(Phe{sup 8})Ang II. Since Ang II antibodies do not recognize des-(Phe{sup 8})Ang II, these finding explain why IR-Ang II in the ZG is due predominantly to Ang II and not to its C-terminal immunoreactive fragments.

  14. The polypeptide backbone of recombinant human zona pellucida glycoprotein-3 initiates acrosomal exocytosis in human spermatozoa in vitro.

    PubMed Central

    Chapman, N; Kessopoulou, E; Andrews, P; Hornby, D; Barratt, C R

    1998-01-01

    Human gamete interaction is of fundamental biological importance, yet the molecular interactions between spermatozoa and the zona pellucida are poorly understood. Surprisingly, the role of the polypeptide backbone of zona pellucida glycoprotein 3 (ZP3), the putative ligand for spermatozoa activation, has been largely overlooked. Purified recombinant human ZP3 was expressed in Escherichia coli as a C-terminal fusion to the dimeric glutathione S-transferase (GST) from Schistosoma japonicum and was shown to induce acrosomal exocytosis in live, capacitated human spermatozoa. The level of exocytosis is comparable with that obtained using purified, glycosylated, recombinant human ZP3 [van Duin, M., Polman, J.E.M., DeBreet, I.T.M., Van Ginneken, K., Bunschoten, H., Grootenhuis, A., Brindle, J. and Aitken, R.J. (1994). Biol Reprod. 51, 607-617]. These data imply that the polypeptide chain of human ZP3 contributes to recognition of spermatozoa during acrosomal exocytosis in vitro. PMID:9480899

  15. Characterization of cell surface polypeptides of unfertilized, fertilized, and protease-treated zona-free mouse eggs

    SciTech Connect

    Boldt, J.; Gunter, L.E.; Howe, A.M. )

    1989-05-01

    The polypeptide composition of unfertilized, fertilized, and protease-treated zona-free mouse eggs was evaluated in this study. Zona-free eggs were radioiodinated by an Iodogen-catalyzed reaction. Light microscopic autoradiography of egg sections revealed that labeling was restricted to the cell surface. Labeled eggs were solubilized, and cell surface polypeptides were identified by one-dimensional SDS polyacrylamide gel electrophoresis and autoradiography. The unfertilized egg demonstrated 8-10 peptides that incorporated {sup 125}I, with major bands observed at approximately 145-150, 94, and 23 kilodaltons (kD). Zona-free eggs fertilized in vitro and then radiolabeled demonstrated several new bands in comparison to unfertilized eggs, with a major band appearing at approximately 36 kD. Treatment of radiolabeled unfertilized eggs with either trypsin or chymotrypsin (1 mg/ml for 5-20 min) caused enzyme-specific modifications in labeled polypeptides. Trypsin (T) treatment resulted in time-dependant modification of the three major peptides at 145-150, 94, and 23 kD. Chymotrypsin (CT) treatment, in contrast, was associated with loss or modification of the 94 kD band, with no apparent effect on either the 145-150 or 23 kD band. Taken together with previous data indicating that T or CT egg treatment interferes with sperm-egg attachment and fusion, these results suggest a possible role for the 94 kD protein in sperm-egg interaction.

  16. La opacidad atmosférica del CASLEO a ondas milimétricas

    NASA Astrophysics Data System (ADS)

    Bareilles, F.; Olalde, J.; Picardo, C.; Guarrera, L.; Arnal, E. M.; Morras, R.; Perilli, D.; Salazar, P.

    Mediante el uso de un radiómetro que trabaja en la frecuencia de 210 GHz, se han realizado mediciones de la transparencia de la atmósfera a esa frecuencia. Los sitios en los que se han realizado las medidas, corresponden al Cerro Negro de la Tina (Cerro Burek), ubicado a unos 2650 m de altura, y a un sitio ubicado a unos 3400 m de altura, localizado en la Pampa del Jarillal. Las mediciones forman parte de una campaña que cubrirá un lapso de tres años, durante la cual se caracterizan distintas zonas ubicadas en la cordillera. Los resultados que se comunican fueron obtenidos durante el período diciembre de 2002 a septiembre de 2003. Se realiza una comparación preliminar entre la opacidad atmosférica de los lugares mencionados y aquélla de otros sitios en los que se encuentran instaladas facilidades observacionales que operan en la banda milimétrica y submilimétrica del espectro.

  17. Uncontacted Waorani in the Yasuní Biosphere Reserve: Geographical Validation of the Zona Intangible Tagaeri Taromenane (ZITT)

    PubMed Central

    Pappalardo, Salvatore Eugenio; De Marchi, Massimo; Ferrarese, Francesco

    2013-01-01

    The Tagaeri Taromenane People are two indigenous groups belonging to the Waorani first nation living in voluntary isolation within the Napo region of the western Amazon rainforest. To protect their territory the Ecuadorean State has declared and geographically defined, by Decrees, the Zona Intangible Tagaeri Taromenane (ZITT). This zone is located within the UNESCO Yasuní Biosphere Reserve (1989), one of the most biodiverse areas in the world. Due to several hydrocarbon reserve exploitation projects running in the area and the advancing of a large-scale deforestation front, the survival of these groups is presently at risk. The general aim was to validate the ZITT boundary using the geographical references included in the Decree 2187 (2007) by analyzing the geomorphological characteristics of the area. Remote sensing data such as Digital Elevation Models (DEM), Landsat imagery, topographic cartography of IGM-Ecuador, and fieldwork geographical data have been integrated and processed by Geographical Information System (GIS). The ZITT presents two levels of geographic inconsistencies. The first dimension is about the serious cartographical weaknesses in the perimeter delimitation related to the impossibility of linking two rivers belonging to different basins while the second deals with the perimeter line not respecting the hydrographic network. The GIS analysis results clearly show that ZITT boundary is cartographically nonsense due to the impossibility of mapping out the perimeter. Furthermore, GIS analysis of anthropological data shows presence of Tagaeri Taromenane clans outside the ZITT perimeter, within oil production areas and in nearby farmer settlements, reflecting the limits of protection policies for non-contacted indigenous territory. The delimitation of the ZITT followed a traditional pattern of geometric boundary not taking into account the nomadic characteristic of Tagaeri Taromenane: it is necessary to adopt geographical approaches to recognize the indigenous right to their liveable territories in the complex territorialities enacted by different stakeholders. PMID:23840436

  18. Evidence for extracellular, but not intracellular, generation of angiotensin II in the rat adrenal zona glomerulosa.

    PubMed Central

    Urata, H; Khosla, M C; Bumpus, F M; Husain, A

    1988-01-01

    Based on the observation that high levels of renin and angiotensin II (Ang II) are found in the adrenal zona glomerulosa (ZG), it has been postulated that Ang II is formed intracellularly by the renin-converting enzyme cascade in this tissue. To test this hypothesis, we examined renin-angiotensin system components in subcellular fractions of the rat adrenal ZG. Renin activity and immunoreactive-Ang II (IR-Ang II) were observed in vesicular fractions but were not colocalized. In addition, angiotensinogen, angiotensin I, and converting enzyme were not observed in the renin or IR-Ang II-containing vesicular fractions. These data do not support the hypothesis that Ang II is formed intracellularly within the renin-containing vesicles of the ZG. Rather, since modulatable renin release from adrenal ZG slices was observed and renin activity was found in dense vesicular fractions (33-39% sucrose), it is likely that Ang II formation in the ZG is extracellular and initiated by the release of vesicular renin. Receptor-mediated endocytosis and subsequent degradation of Ang II in ZG lysosomes have been shown by others. The presence of IR-Ang II in light vesicular fractions (15% sucrose) and the finding of a high correlation between ZG IR-Ang II and Ang II receptor levels suggest that the primary occurrence of this peptide in the ZG is by receptor-mediated endocytosis. In ZG lysosomal fractions 125I-labeled Ang II was degraded to 125I-labeled des-[Phe8]Ang II. Since Ang II antibodies do not recognize des-[Phe8]Ang II, these findings explain why IR-Ang II in the ZG is due predominantly to Ang II and not to its C-terminal immunoreactive fragments. Images PMID:2847156

  19. Uncontacted Waorani in the Yasuní Biosphere Reserve: Geographical Validation of the Zona Intangible Tagaeri Taromenane (ZITT).

    PubMed

    Pappalardo, Salvatore Eugenio; De Marchi, Massimo; Ferrarese, Francesco

    2013-01-01

    The Tagaeri Taromenane People are two indigenous groups belonging to the Waorani first nation living in voluntary isolation within the Napo region of the western Amazon rainforest. To protect their territory the Ecuadorean State has declared and geographically defined, by Decrees, the Zona Intangible Tagaeri Taromenane (ZITT). This zone is located within the UNESCO Yasuní Biosphere Reserve (1989), one of the most biodiverse areas in the world. Due to several hydrocarbon reserve exploitation projects running in the area and the advancing of a large-scale deforestation front, the survival of these groups is presently at risk. The general aim was to validate the ZITT boundary using the geographical references included in the Decree 2187 (2007) by analyzing the geomorphological characteristics of the area. Remote sensing data such as Digital Elevation Models (DEM), Landsat imagery, topographic cartography of IGM-Ecuador, and fieldwork geographical data have been integrated and processed by Geographical Information System (GIS). The ZITT presents two levels of geographic inconsistencies. The first dimension is about the serious cartographical weaknesses in the perimeter delimitation related to the impossibility of linking two rivers belonging to different basins while the second deals with the perimeter line not respecting the hydrographic network. The GIS analysis results clearly show that ZITT boundary is cartographically nonsense due to the impossibility of mapping out the perimeter. Furthermore, GIS analysis of anthropological data shows presence of Tagaeri Taromenane clans outside the ZITT perimeter, within oil production areas and in nearby farmer settlements, reflecting the limits of protection policies for non-contacted indigenous territory. The delimitation of the ZITT followed a traditional pattern of geometric boundary not taking into account the nomadic characteristic of Tagaeri Taromenane: it is necessary to adopt geographical approaches to recognize the indigenous right to their liveable territories in the complex territorialities enacted by different stakeholders. PMID:23840436

  20. Role of sperm surface arylsulfatase A in mouse sperm-zona pellucida binding.

    PubMed

    Tantibhedhyangkul, Julierut; Weerachatyanukul, Wattana; Carmona, Euridice; Xu, Hongbin; Anupriwan, Araya; Michaud, Dominick; Tanphaichitr, Nongnuj

    2002-07-01

    We have previously described the zonae pellucidae (ZP) binding ability of a pig sperm surface protein, P68. Our recent results on peptide sequencing of 3 P68 tryptic peptides and molecular cloning of pig testis arylsulfatase A (AS-A) revealed the identity of P68 as AS-A. In this report, we demonstrate the presence of AS-A on the mouse sperm surface and its role in ZP binding. Using anti-AS-A antibody, we have shown by immunoblotting that AS-A was present in a Triton X-100 extract of mouse sperm. The presence of AS-A on the sperm plasma membrane was conclusively demonstrated by indirect immunofluorescence, immunogold electron microscopy, and AS-A's desulfation activity on live mouse sperm. The AS-A remained on the head surface of in vivo capacitated sperm, as revealed by positive immunofluorescent staining of oviductal/uterine sperm. Significantly, the role of mouse sperm surface AS-A on ZP binding was demonstrated by dose-dependent decreases of sperm-ZP binding on sperm pretreatment with anti-AS-A IgG/Fab. Furthermore, Alexa-430 conjugated AS-A bound to mouse ZP of unfertilized eggs but not to fertilized ones, and this level of binding increased and approached saturation with increasing Alexa-430 AS-A concentrations. Moreover, in vivo fertilization was markedly decreased when mouse sperm pretreated with anti-AS-A IgG were artificially inseminated into females. All of these results designated a new function for AS-A in mouse gamete interaction. PMID:12080020

  1. Feasibility and challenges in the development of immunocontraceptive vaccine based on zona pellucida glycoproteins.

    PubMed

    Choudhury, Sangeeta; Srivastava, Neelu; Narwal, P S; Rath, Archana; Jaiswal, Sonika; Gupta, Satish K

    2007-01-01

    The zona pellucida (ZP) glycoproteins play a crucial role during fertilization and thus are considered as important target antigens for the development of immunocontraceptive vaccines aiming to inhibit fertility at a pre-fertilization stage. In order to evaluate the immunocontraceptive potential of ZP glycoproteins, bonnet monkey (Macaca radiata) ZP2, ZP3 and ZP4 have been cloned and expressed using either E. coli or baculovirus expression systems. Active immunization studies with the recombinant ZP glycoproteins in female baboons (Papio anubis) and bonnet monkeys revealed curtailment of fertility. In order to minimize the ovarian pathology, synthetic peptides corresponding to B cell epitopes that are devoid of 'oophoritogenic' T cell epitopes were designed and their in vitro immunocontraceptive potential explored. There are several issues that need to be addressed before ZP glycoproteins based immunocontraceptive vaccines become feasible for use in humans. Nonetheless, the utility of such a vaccine is imminent for controlling wild life population. In this direction, active immunization of female non-descript dogs with recombinant canine ZP3 conjugated to diphtheria toxoid led to curtailment of fertility. Further, canine ZP3 has also been expressed in insect cells as a fusion protein with rabies virus glycoprotein G (RV-G), an antigen that is involved in providing protection against rabies. The immunogenicity of such a recombinant protein and its potential to curtail fertility was explored both in female mice and dogs. Simultaneously, DNA vaccine encoding canine ZP3 and RV-G have been made and evaluated for their immunogenicity. The results obtained so far, current shortcomings and the possible ways to circumvent these have been discussed in the present manuscript. PMID:17566293

  2. Foaling rates in feral horses treated with the immunocontraceptive porcine zona pellucida

    USGS Publications Warehouse

    Ransom, J.I.; Roelle, J.E.; Cade, B.S.; Coates-Markle, L.; Kane, A.J.

    2011-01-01

    Locally abundant feral horses (Equus caballus) can rapidly deplete available resources. Fertility control agents present promising nonlethal tools for reducing their population growth rates. We tested the effect of 2 forms of the immunocontraceptive porcine zona pellucida (PZP) on foaling rates in 3 populations of feral horses in the western United States. A liquid form requiring annual boosters was administered at Little Book Cliffs Wild Horse Range, Mesa County (CO), and Pryor Mountain Wild Horse Range, Bighorn County (WY) and Carbon County (MT), and a time-release pellet form designed to produce 2 yr of infertility was administered at McCullough Peaks Herd Management Area, Park County (WY). Average foaling rates (foals born/mare-yr) from direct observation of untreated and treated female horses (mares), 2004-2008, were 60.1% (n = 153 mare-yr) versus 6.6% (n = 91 mare-yr) at Little Book Cliffs, and 62.8% (n = 129 mare-yr) versus 17.7% (n = 79 mare-yr) at Pryor Mountain, respectively. At McCullough Peaks, mean annual foaling rates from 2006 to 2008 were 75.0% (n = 48 mare-yr) for untreated mares and 31.7% (n = 101 mare-yr) for treated mares. Controlling for age of mares and pretreatment differences in fertility, PZP reduced foaling rates in all 3 herds. The pellets used at McCullough Peaks (produced by cold evaporation) were less effective than pellets used in a previous trial and produced by heat extrusion. Immunocontraception with PZP may be a useful tool in reducing fertility rates in some western United States feral horse herds, but population growth reduction will depend on timely access to mares for inoculation and the proportion of mares that can be successfully treated. ?? 2011 The Wildlife Society.

  3. Timing of zona pellucida formation in the tammar wallaby (Macropus eugenii) and brushtail possum (Trichosurus vulpecula).

    PubMed

    Mate, K E

    1998-10-01

    The zona pellucida (ZP) is an extracellular coat that surrounds the mammalian egg, and serves as the primary recognition site for fertilizing spermatozoa. The timetable of ZP formation was examined in two marsupials, the tammar wallaby (Macropus eugenii) and the brushtail possum (Trichosurus vulpecula) using conventional histological methods, immunofluorescence and electron microscopy. Ovaries from tammar wallaby pouch young less than 80 days of age contained only primordial follicles with a single layer of flattened granulosa cells. There was no evidence of ZP formation until 98 days, when a small number of eggs surrounded by a single layer of cuboidal granulosa cells had a ZP detectable by periodic-acid-schiff staining and rabbit anti-pig ZP polyclonal antibody labelling. Possum ovaries at 108 and 114 days also contained a small number of eggs with a ZP and a single layer of cuboidal granulosa cells. The antibody also labelled the peripheral cytoplasm of oocytes at this stage and, occasionally, the granulosa cells. Antral follicles were first detected at 144 days in the wallaby and 125 days in the possum, and always contained an egg surrounded by a ZP. Ovaries from 147, 158, 165, 181, 184 and 210-day-old tammar wallabies contained a range of follicle types from primordial through early antrum formation. Electron microscopy confirmed observations made at the light microscope level. The ZP was first detectable in small primary follicles with a single layer of cuboidal granulosa cells in areas where microvilli had begun to form on the egg plasma membrane. Immunogold labelling indicated the egg cytoplasm as the origin of the ZP proteins. The ZP completely filled the space between the egg and the adjacent granulosa cells in preantral follicles, so that there was no perivitelline space. PMID:9835379

  4. Ability of Catalonian donkey sperm to penetrate zona pellucida-free bovine oocytes matured in vitro.

    PubMed

    Taberner, E; Morató, R; Mogas, T; Miró, J

    2010-04-01

    An experiment was designed to study the interaction between fresh/frozen-thawed donkey spermatozoa and zona pellucida (ZP)-free bovine oocytes in an attempt to develop a model for assessing cryopreserved Catalonian donkey sperm function. Semen from five donkeys was collected using an artificial vagina. Sperm motility and viability were immediately assessed and the semen sample cryopreserved. Sperm viability and motility were then reassessed immediately after thawing. The motion characteristics of the fresh and frozen-thawed spermatozoa were determined using a computer-assisted sperm analysis system. In vitro-matured cow oocytes were inseminated with different percent live donkey sperm (high (>60%) or low (<40%) viability donkey sperm). After 18h of co-incubation, the oocytes were fixed, stained with 4',6-diamidino-2-phenylindole (DAPI) and examined for sperm penetration, the number of penetrated spermatozoa per oocyte, and male pronucleus formation. Frozen-thawed spermatozoa from high viability semen showed significantly lower VCL, VAP and mean ALH values than did high viability fresh spermatozoa. In contrast, frozen-thawed spermatozoa of low viability had significantly higher velocity values than fresh spermatozoa of low viability. A significant positive correlation (P<0.01) was detected between percentage fertilization and viability (r=0.84), and between percentage fertilization and certain CASA parameters (VAP, r=0.56; VCL, r=0.61 and mean ALH, r=0.68). Fresh or frozen-thawed high viability spermatozoa penetrated 90.1% and 85.4% of bovine oocytes respectively. Lower rates of penetration were observed for fresh and frozen-thawed low viability spermatozoa (34% and 22.5% respectively). The donkey spermatozoa were able to fuse with the oolema and even to decondense and form the male pronucleus (85-94%). Larger numbers of penetrated spermatozoa per oocyte were recorded when high viability sperm samples were used, whether fresh (3.02 vs. 1.12 for low viability sperm) or frozen-thawed (3.41 vs. 1.47). Consequently, low viability sperm samples showed higher percentages of monospermic penetration (91.17% and 61.97% for fresh and frozen-thawed sperm samples respectively). These findings suggest that bovine oocytes provide a useful model for assessing the penetration potential of frozen-thawed donkey sperm. PMID:19748750

  5. Atlas del Genoma del Cáncer: Antecedentes

    Cancer.gov

    El Atlas del Genoma del Cáncer es una iniciativa de los Institutos Nacionales de la Salud (NIH) para crear mapas multidimensionales completos de los cambios genómicos clave en los tipos y subtipos principales de cáncer.

  6. Assessment of in vitro fertility of deer spermatozoa by heterologous IVF with zona-free bovine oocytes.

    PubMed

    Comizzoli, P; Mauget, R; Mermillod, P

    2001-07-15

    We have previously shown that the in vitro development of deer embryos differed according to the IVF conditions. The aim of the study was to use heterologous IVF with zona-free matured bovine oocytes to assess the in vitro fertility of 3 samples of deer semen (2 ejaculates from sika deer (Cervus nippon) and 1 pool of epididymal spermatozoa from red deer (Cervus elaphus)). The frozen/thawed semen samples were selected on Percoll gradient and resuspended in Tyrode modified medium supplemented with estrus sheep serum (0, 2, 20% v/v) or heparin (10 microg/mL). During 8 h of culture, the sperm motility index according to the post-insemination time (hpi) did not differ either between samples or between supplemented IVF media. In vitro matured zona-free bovine oocytes were inseminated in different IVF media with the semen samples. Penetration rates assessed at 15 hpi were optimal with 20% estrus sheep serum for sika deer ejaculates whereas 2% were sufficient to reach the maximum functionality of epididymal spermatozoa from red deer. The mean time of pronuclear formation was similar regardless of the semen sample. The precocity of the onset of the first S-phase in both pronuclei was characterized by Bromo-deoxy-Uridine exposures between 5 and 15 hpi in order to assess the developmental potential conferred by the semen sample (intrinsic value). As we previously observed in homologous IVF, this value seemed to be higher for the epididymal sperm sample. PMID:11480618

  7. Effect of laser-assisted multi-point zona thinning on development and hatching of cleavage embryos in mice

    PubMed Central

    Lee, Young Seok; Park, Min Jung; Park, Sea Hee; Koo, Ja Seong

    2015-01-01

    Objective This study aimed to examine the effect of laser-assisted zona thinning (LAZT) at one or four-points on the blastocyst formation and hatching process in mice with respect to female age. Methods Eight-cell or morula embryos collected from superovulated C57BL female mice with different ages (6-11 and 28-31 weeks) were treated with LAZT at one-point (LAZT1) or four-points (LAZT4). The zona pellucida was thinned to more than 70% of its initial thickness by making two holes of 15-20 µm. Results In the young mice, LAZT resulted in a significant increase in early hatching and hatching rates compared to the control group (p<0.05). However, in the old mice, LAZT significantly increased blastocyst formation as well as early hatching and hatching compared to the controls (p<0.05). These effects were more remarkable in LAZT4 than in LAZT1 and in aged mice than in young ones. Conclusion These results show that multi-point LAZT leads to a significant improvement of blastocyst formation and hatching in mice compared to controls. PMID:26161333

  8. Efficacy of zona-free hamster egg sperm penetration assay as a predictor of in vitro fertilization.

    PubMed

    Ibrahim, M E; Moussa, M A; Pedersen, H

    1989-01-01

    The efficacy of the zona-free hamster egg sperm penetration assay (SPA) as a predictor of in vitro fertilization (IVF) is studied. Indications for IVF were tubal factors in 35 couples and male factors in 24 couples. The diagnostic characteristics of SPA in reference to IVF for the whole group (n = 59) were reasonably reliable. Sensitivity was 74%, specificity was 84%, and diagnostic accuracy was 81%. However in patients with male factors, SPA was less reliable in terms of sensitivity (70%), specificity (57%), and diagnostic accuracy (63%), than in patients with tubal factors where the indicators were 80%, 97%, and 94%, respectively. Semen from patients with male infertility shared notable variations in terms of sperm density and motility which may account for the low SPA predictivity. SPA seems to be a useful screening test for prediction of IVF outcome. However other semen variables should be considered before interpretation, especially in male infertility where the diagnostic accuracy is low. PMID:2619415

  9. RACEMIZATION OF METEORITIC AMINO ACIDS. B. A. Cohen1 and C. F. Chyba, The University of Ari-zona, Tucson AZ 85719 1bcohen@lpl.arizona.edu.

    E-print Network

    Cohen, Barbara Anne

    RACEMIZATION OF METEORITIC AMINO ACIDS. B. A. Cohen1 and C. F. Chyba, The University of Ari- zona, Tucson AZ 85719 1bcohen@lpl.arizona.edu. Amino acids are the building blocks of proteins, among the most biologically critical molecules. It was first noted in the 1800's that the vast majority of amino acids used

  10. Articulatory Closure Proficiency in Patients with Parkinson's Disease Following Deep Brain Stimulation of the Subthalamic Nucleus and Caudal Zona Incerta

    ERIC Educational Resources Information Center

    Karlsson, Fredrik; Olofsson, Katarina; Blomstedt, Patric; Linder, Jan; Nordh, Erik; van Doorn, Jan

    2014-01-01

    Purpose: The present study aimed at comparing the effects of deep brain stimulation (DBS) treatment of the subthalamic nucleus (STN) and the caudal zona incerta (cZi) on the proficiency in achieving oral closure and release during plosive production of people with Parkinson's disease. Method: Nineteen patients participated preoperatively and…

  11. Los plaguicidas y la contaminacion del medio ambiente Venezolano

    USGS Publications Warehouse

    Stickel, L.F.; Stickel, W.H.

    1972-01-01

    RESUMEN DE RECOMENDACIONES Recomendaciones para el Programa de Investigacion: 1. Establecer un sistema de muestreo biologico para detectar los niveles tendencias de los productos quimicos toxicos en un peque?o numero de si tios representativos. 2. Mantener continua vigilancia de la contaminacion ambiental, mediante la seleccion acertadamente dirigida de las zonas afectadas y de las fuentes de contaminacion. 3. Realizar estudios acerca de las poblaciones de animales silvestres, y del exito de los procesos reproductivos de las especies o grupos clayes de animales que se consideran mas gravemente afectados. 4. Preparar recomendaciones para una accion gubernamental de proteccion al hombre, a la fauna silvestre y al medio ambiente. Recomendaciones para la Accion Administrativa: 1. Establecer limites a la tolerancia de los residuos de plaguicidas en los alimentos. Constituye una medida clave para disminuir la contaminacion ambiental. 2. Establecer normas de calidad del agua para las corrientes, represas, la gos y otros cuerpos. Es la segunda medida clave para reducir la contaminacion del ambiente 3. Exigir un tratamiento adecuado de los efluentes industriales, especialmente antes de que se construyan las nuevas plantas. 4. Exigir a los agricultores que en el uso de plaguicidas sigan los consejos tecnicos autorizados y negar a los vendedores el derecho a recomendar productos por su cuenta. 5. Tomar medidas para recoger y eliminar los recipientes y sobrantes de los plaguicidas.

  12. Instantánea del cáncer colorrectal

    Cancer.gov

    Información sobre las tendencias de incidencia, mortalidad y financiamiento del NCI sobre el cáncer colorrectal; así como ejemplos de actividades del NCI y adelantos en la investigación de este tipo de cáncer.

  13. Estadísticas del cáncer

    Cancer.gov

    Información básica sobre las estadísticas del cáncer, las cuales describen las tendencias en grupos grandes de personas y ofrecen una imagen a través del tiempo de la carga que representa el cáncer en la sociedad.

  14. Moléculas orgánicas obtenidas en simulaciones experimentales del medio interestelar.

    NASA Astrophysics Data System (ADS)

    Muñoz-Caro, Guillermo Manuel

    Las nubes moleculares son regiones de formación de estrellas, con temperaturas cinéticas entre 10-50 K y densidades de 103-106 átomos cm-3. Su materia está formada por gas y polvo interestelar. Estas partículas de polvo están cubiertas por una fina capa de hielo, de unos 0.01 ?m, que contiene H2O y a menudo CO, CO2, CH3OH y NH3. El hielo es presumiblemente irradiado por fotones ultravioleta y rayos cósmicos en las zonas poco profundas de las nubes moleculares y las regiones circunestelares. En un sistema de vacío, P ˜ 10-7 mbar, simulamos la deposición de hielo a partir de 10 K y la irradiación ultravioleta por medio de una lámpara de descarga de hidrógeno activada con microondas. La evolución del hielo se observa por medio de un espectrómetro infrarrojo. De este modo es posible determinar la composición del hielo observado en el medio interestelar y predecir la presencia de moléculas aún no detectadas en el espacio, que han sido producto del procesamiento del hielo en nuestros experimentos. También es posible calentar el sistema hasta temperatura ambiente para sublimar el hielo depositado. Cuando el hielo ha sido previamente irradiado, se observa un residuo compuesto por moléculas orgánicas complejas, algunas prebióticas, como varios ácidos carboxílicos, aminas, amidas, ésteres y en menor proporción moléculas heterocíclicas y aminoácidos. Algunas de estas moléculas podrían detectarse en estado gaseoso por medio de observaciones milimétricas y de radio. También podrían estar presentes en el polvo cometario, cuyo análisis químico está planeado por las misiones Stardust y Rosetta. Mientras tanto, nuestro grupo está llevando a cabo el análisis de partículas de polvo interplanetario (IDPs), algunas de las cuales pueden ser de origen cometario. Al igual que ocurre con los productos obtenidos por irradiación del hielo en nuestros experimentos, algunas IDPs son ricas en material orgánico que contiene oxígeno.

  15. Preguntas y respuestas acerca del Estudio del

    Cancer.gov

    El Estudio del Tamoxifeno y Raloxifeno (STAR, por sus siglas en ingls) es un estudio clnico (un estudio de investigacin conducido con voluntarios) diseado para ver cómo el medicamento raloxifeno (Evista) se compara con el medicamento tamoxifeno (Nolvadex)

  16. Effects of components of semen extenders on the binding of stallion spermatozoa to bovine or equine zonae pellucidae.

    PubMed

    Coutinho da Silva, Marco A; Seidel, George E; Squires, Edward L; Graham, James K; Carnevale, Elaine M

    2012-05-01

    The effects of semen extender components on the ability of stallion sperm to bind to the zona pellucida (ZP) and the suitability of using bovine ZP for a ZP-binding assay for stallion sperm were investigated in a series of experiments. In Experiment I, binding of stallion sperm to both bovine and equine ZP was significantly increased when a skim milk-based extender (EZM) was used. In Experiment II, a threefold increase in sperm binding to ZP was observed when sperm were diluted in EZM compared with diluents, which contained no milk (TALP, LAC, and EmCare). In Experiment III, centrifuging the sperm through Percoll did not increase sperm binding to the ZP but did remove any positive effect of EZM on sperm-ZP binding. In Experiment IV, exposure of either sperm or ZP to EZM before co-incubation did not increase sperm binding to ZP. In Experiment V, sperm diluted in TALP containing skim milk, EZM, or INRA96 bound more efficiently to the ZP than sperm diluted in TALP without milk proteins. In Experiment VI, sodium caseinate, native phosphocaseinate, and caseinoglycopeptide increased sperm binding to the ZP. In conclusion, diluents containing milk or milk proteins markedly enhanced the number of sperm bound to both equine and bovine ZP. PMID:22419829

  17. The effect of porcine follicular fluid on the interaction of boar spermatozoa with zona-free hamster ova.

    PubMed Central

    Ramsoondar, J; Downey, B R; Bousquet, D

    1991-01-01

    Boar spermatozoa were cocultured with zona-free hamster ova (eggs) to assess the effects of preovulatory porcine follicular fluid (pFF) in the capacitation medium or gamete coculture (fertilization) medium (pFF; 0, 10 or 40% v/v) on subsequent sperm-egg interaction. Increasing pFF concentrations in the capacitation medium resulted in a progressive decrease in the average numbers of sperm attaching to or penetrating each ovum. When pFF was included in the fertilization medium, but not in the capacitation medium, the average numbers of sperm attaching to or penetrating each ovum and the percentage of ova with sperm attached decreased markedly with increasing pFF concentrations. The percentage of ova with greater than five sperm attached decreased from 84% to 13% and 0% with 0%, 10% and 40% pFF, respectively. Sperm attachment was completely inhibited in approximately 50% of the ova cocultured in 40% pFF. The percentage of ova penetrated by greater than five sperm decreased from 82% to 21% and 7% with 0%, 10% and 40% pFF, respectively. Preincubation of ova in 40% pFF prior to coculture with sperm also resulted in a reduction in sperm attachment and penetration. These results suggest that pFF contains substance(s) that alter the ability of boar spermatozoa to interact with the hamster ovum plasma membrane in vitro. Images Fig. 1. Fig. 2. PMID:1889030

  18. Deep Brain Stimulation of Caudal Zona Incerta and Subthalamic Nucleus in Patients with Parkinson's Disease: Effects on Diadochokinetic Rate

    PubMed Central

    Karlsson, Fredrik; Unger, Elin; Wahlgren, Sofia; Blomstedt, Patric; Linder, Jan; Nordh, Erik; Zafar, Hamayun; van Doorn, Jan

    2011-01-01

    The hypokinetic dysarthria observed in Parkinson's disease (PD) affects the range, speed, and accuracy of articulatory gestures in patients, reducing the perceived quality of speech acoustic output in continuous speech. Deep brain stimulation (DBS) of the subthalamic nucleus (STN-DBS) and of the caudal zona incerta (cZi-DBS) are current surgical treatment options for PD. This study aimed at investigating the outcome of STN-DBS (7 patients) and cZi-DBS (7 patients) in two articulatory diadochokinesis tasks (AMR and SMR) using measurements of articulation rate and quality of the plosive consonants (using the percent measurable VOT metric). The results indicate that patients receiving STN-DBS increased in articulation rate in the Stim-ON condition in the AMR task only, with no effect on production quality. Patients receiving cZi-DBS decreased in articulation rate in the Stim-ON condition and further showed a reduction in production quality. The data therefore suggest that cZi-DBS is more detrimental for extended articulatory movements than STN-DBS. PMID:22007342

  19. Sperm characteristics and zona pellucida binding in relation to field fertility of frozen-thawed semen from dairy AI bulls.

    PubMed

    Zhang, B R; Larsson, B; Lundeheim, N; Rodriguez-Martinez, H

    1998-08-01

    The present study examined the relationship between bull sperm characteristics immediately post-thaw and some characteristics registered after swim-up, including the ability of spermatozoa to bind to homologous zona pellucidae (ZP) in vitro, and fertility after artificial insemination (AI) of 9426 females. Frozen-thawed semen from 22 AI bulls of the Swedish Red and White Breed, represented by 43 different frozen batches (1-4 batches/bull, 2 consecutive ejaculates/batch), was examined with the aim of determining concentration, motility patterns, morphology and membrane integrity. In addition, the frozen-thawed spermatozoa were subjected to a swim-up procedure and those separated in this way were tested with two assays of sperm-binding to the ZP of homologous oocytes in vitro (ZBA), using either a relative ZBA index against a control bull of proven high fertility or absolute binding (Absolute ZBA). The correlations of the various sperm traits and 56-day non-return rates (NRR) after field AI were retrospectively examined as single traits and as combinations of traits (combined measures), including regression analysis of significant traits. Among the sperm characteristics, positively significant (p < 0.01) correlations with NRR were found for linear motility post-thawing (r = 0.45-0.59) and the concentration of motile spermatozoa after swim-up (r = 0.43-0.63). Results obtained with the absolute ZBA approach were significantly (p < 0.05) correlated with NRR (r = 0.50), whereas the correlation between NRR and the ZBA index was not significant. The use of combined measures of sperm traits, including the ability to bind to ZP, showed a stronger predictive correlation with NRR (r = 0.68-0.75), compared with single traits. The results suggest that the combined analysis of sperm linear-motility patterns, swim-up separated sperm motility and absolute ZBA can provide a valuable assessment of the fertilizing capacity of AI bull semen. PMID:9749351

  20. Expression and cellular distribution of zona pellucida glycoproteins in canine oocytes before and after in vitro maturation.

    PubMed

    Kempisty, Bartosz; Piotrowska, Hanna; Bukowska, Dorota; Wo?na, Magdalena; Ciesió?ka, Sylwia; Wojtanowicz-Markiewicz, Katarzyna; W?odarczyk, Renata; Jopek, Karol; Jeseta, Michal; Bruska, Ma?gorzata; Nowicki, Micha?; Ja?kowski, J?drzej M; Brüssow, Klaus-Peter; Zabel, Maciej

    2015-12-01

    This study was aimed at investigating zona pellucida glycoproteins (ZP) ZP2, ZP3 mRNA expression as well as ZP3, ZP4 (ZPB) protein distribution before and after in vitro maturation (IVM) in canine oocytes. The cumulus-oocyte complexes (COCs) were recovered from 27 anoestrous mongrel bitches and matured for 72 h in TCM199 medium. The canine COCs were analysed before and after IVM. Using real-time quantitative polymerase chain reaction (RQ-PCR), both groups of oocytes were analysed for detection of ZP2 and ZP3 mRNA profiles as well as using confocal microscopic analysis for observation of ZP3 and ZP4 protein distribution. In post-IVM canine oocytes an increase in transcript content of ZP2 and ZP3 genes as well as a decrease in ZP3 and ZP4 protein levels were observed when compared with pre-IVM oocytes. Moreover, the ZP4 protein before IVM was significantly distributed in the peripheral area of cytoplasm, whereas after IVM it was localized rather than in the entire cytoplasm. In contrast, the ZP3 protein was found both before and after IVM was distributed in the peripheral area of the cytoplasm. In conclusion, we suggest that the expression of ZP2 and ZP3 genes is associated with the maturation stage of canine oocytes, as higher mRNAs levels were found after IVM. However, a decreased expression of ZP3 and ZP4 proteins after IVM suggests maturation-dependent down-regulation of these protein translations, which may result in disturbed fertilization. PMID:25315095

  1. Bacterial ghosts as a delivery system for zona pellucida-2 fertility control vaccines for brushtail possums (Trichosurus vulpecula).

    PubMed

    Walcher, Petra; Cui, Xianlan; Arrow, Jane A; Scobie, Susie; Molinia, Frank C; Cowan, Phil E; Lubitz, Werner; Duckworth, Janine A

    2008-12-01

    The introduced brushtail possum is a serious pest in New Zealand and there is much interest in the development of an immunocontraceptive vaccine for population control. Immunisation of female possums against recombinant possum zona pellucida protein-2 (ZP2) is known to reduce embryo production by 72-75% but successful development of fertility control will depend on a delivery system that is effective for field use. Bacterial ghost vaccine technology is a promising system to formulate a non-living vaccine for bait or aerosol delivery. The N-terminal (amino acid residues 41-316, ZP2N) and C-terminal (amino acid residues 308-636, ZP2C) regions of possum ZP2 were fused to maltose-binding protein and expressed in the periplasmic space of Escherichia coli NM522 bacterial ghosts. Female possums (n=20 per treatment group) were immunised with 20mg of either plain ghosts, ZP2N ghosts, or ZP2C ghosts in phosphate-buffered saline applied to the nostrils and eyes (nasal/conjunctival mucosa) at weeks 0, 2 and 4. Effects of immunisation on fertility were assessed following superovulation and artificial insemination. Both constructs evoked humoral (antibody) and cell-mediated immune responses in possums and significantly fewer eggs were fertilised in females immunised against ZP2C ghosts. Results in this study indicate that bacterial ghosts containing possum ZP antigens can reduce possum fertility when delivered by mucosal immunisation and offer a promising delivery system for fertility control of wild possum populations. PMID:18948157

  2. Interleukin-6 inhibits adrenal androgen release from bovine adrenal zona reticularis cells by inhibiting the expression of steroidogenic proteins.

    PubMed

    McIlmoil, S; Call, G B; Barney, M; Strickland, J; Judd, A M

    2015-10-01

    Interleukin-6 (IL-6) is secreted by adrenocortical cells and modifies cortisol secretion. In this study, the effects of IL-6 on adrenal androgen release were investigated. The zona reticularis (ZR) was generally isolated from bovine adrenal glands by dissection. In select experiments, the intact adrenal cortex (ie, all 3 adrenocortical zones) was dissected from the adrenal glands. For androgen release experiments, ZR and intact adrenocortical cubes were dispersed into isolated cells, the cells cultured and exposed to IL-6 and/or adrenocorticotropic hormone (ACTH), and androgen release determined by radioimmunoassay. Basal and ACTH-stimulated androgen release from the ZR was inhibited by IL-6 in a concentration-dependent (10-1000 pg/mL) and time-dependent (4-24 h) manner (P < 0.01 by 1-way analysis of variance and the Bonferroni test). In contrast, IL-6 increased basal and ACTH-stimulated androgen release from mixed adrenocortical cells (P < 0.01). The mechanism of IL-6 inhibition of androgen release was investigated by exposing ZR strips to IL-6 and measuring the expression of the messenger RNA (mRNA) and protein of steroidogenic factors. Basal and ACTH-stimulated expression of the mRNA and protein for steroidogenic acute regulatory protein, cholesterol side chain cleavage enzyme, 3-?-hydroxysteroid dehydrogenase type 2, steroid 17-?-hydroxylase/17,20 lyase/17,20 desmolase, and the nuclear factor steroidogenic factor 1 (SF-1), that stimulates steroidogenesis, were decreased by IL-6 (P < 0.01). In contrast IL-6 increased the mRNA and protein for dosage-sensitive sex reversal, adrenal hypoplasia critical region, on chromosome X, gene 1 (DAX-1), a nuclear factor that inhibits steroidogenesis (P < 0.01). In summary, IL-6 decreased androgen release and the expression of steroidogenic factors in the ZR, and this decrease may be mediated in part through increasing DAX-1 and decreasing SF-1. PMID:26218834

  3. Humoral immune responses in brushtail possums (Trichosurus vulpecula) induced by bacterial ghosts expressing possum zona pellucida 3 protein.

    PubMed

    Cui, Xianlan; Duckworth, Janine A; Lubitz, Petra; Molinia, Frank C; Haller, Christoph; Lubitz, Werner; Cowan, Phil E

    2010-06-11

    The introduced common brushtail possum (Trichosurus vulpecula) is a major pest in New Zealand and immunocontraceptive vaccines are being developed for biocontrol of possum populations, with bacterial ghosts (BGs) being evaluated as a means of oral delivery. Recombinant BGs expressing possum zona pellucida 3 protein (ZP3) as an L' membrane-anchored protein (ZP3-L') or as an S-layer SbsA-fusion protein (MBP-SbsA-ZP3) were produced by the expression of the cloned bacteriophage phiX174 lysis gene E in E. coli NM522. The humoral immune responses of possums immunised with BGs expressing possum ZP3 were investigated following oral, intranasal/conjunctival, parenteral, and intraduodenal administration to evaluate the BG-ZP3 system for possum fertility control. Antibodies to possum ZP3 were detected in the serum, oviduct secretions, and follicular fluid of immunised animals. Intranasal/conjunctival immunisation elicited reliable antibody immune response in serum and at a key effector site, the ovarian follicular fluid. Intraduodenal administration of possum ZP3 BG vaccine as a priming immunisation elicited significant systemic immune responses, but oral immunisation did not, indicating that protection of BG vaccines from degradation by gastric acidity would enhance the effectiveness of orally delivered vaccines. The detection of antibodies at elevated levels at target sites in the reproductive tract following mucosal delivery demonstrates, for the first time, the potential of BGs as an effective system for vaccine delivery to wild animals, and intranasal/conjunctival immunisation as a promising means for delivery of immunocontraceptive vaccines to wild animals. PMID:20434548

  4. Centro Clnico del NIH Manual del Paciente

    E-print Network

    Shen, Jun

    39 Programa de los amigos de la Familia 39 s e C C i ó n 5 SERVICIOS DE APOYO PARA LOS PACIENTES Y LAS FAMILIAS servicios de trabajo social 42 Servicios de peluquería y cosmetología Programa de los Amigos de la Familia (Family Friend Program) Programa para el familiar/encargado del paciente

  5. Single-treatment porcine zona pellucida immunocontraception associated with reduction of a population of white-tailed deer (Odocoileus virginianus).

    PubMed

    Rutberg, Allen T; Naugle, Ricky E; Verret, Frank

    2013-12-01

    Previous reports have demonstrated gradual reductions of white-tailed deer (Odocoileus virginianus) populations through immunocontraception, with stabilization occurring after 2-4 yr of treatment, and subsequent reductions of 6-10% annually. These studies employed porcine zona pellucida (PZP) vaccines that required two initial treatments and annual retreatments. From 2005 to 2010, 258 adult and yearling female deer on Fripp Island, South Carolina, were treated with one of several PZP preparations designed to produce 2+ yr of effective contraception with a single treatment. These included several preparations of SpayVac and of native PZP-adjuvant emulsion plus PZP and QA-21 in timed-release pellets. Deer were chemically immobilized, ear-tagged, and administered initial treatments by hand in February-March. Some treated deer were boosted remotely with PZP-adjuvant emulsion 1.5 - 4.5 yr after initial treatments. Ground-based distance sampling was used to estimate deer population density at Fripp Island, a resort community, and at a relatively undeveloped neighboring control site, Hunting Island. Most vaccine preparations tested reduced fawning rates by 75% to 95% for at least 1 yr. From 2005 to 2011, deer density on Fripp Island declined by 50%, from 72 deer/km(2) to 36 deer/km(2), an average annual reduction of 11%. In contrast, population density on the Hunting Island control site fluctuated between 2005 and 2011, averaging 23 deer/km(2) (range, 19-28 deer/km(2)). Population declines on Fripp Island were associated with an increase in the proportion of treated females and with a progressive decrease in winter fawn:doe ratios, from 1.21 fawns/doe in 2005 to 0.19 fawns/doe in 2010. Winter fawn:doe ratios averaged 1.36 fawns/doe (range, 0.84 - 1.62 fawns/doe) at the Hunting Island control site. Annual survivorship averaged approximately 79% among ear-tagged females. The rate at which deer populations diminished in association with PZP treatments on Fripp Island was higher than that seen at other study sites, although the reasons for the more rapid decline on Fripp Island are not well understood. PMID:24437087

  6. Política de comentarios del NCI

    Cancer.gov

    Las opiniones expresadas en los comentarios reflejan las del autor y no necesariamente los puntos de vista oficiales del Instituto Nacional del Cáncer, los Institutos Nacionales de la Salud, el Departamento de Salud y Servicios Humanos de los EE. UU o del gobierno federal.

  7. Hojas informativas del NCI

    Cancer.gov

    La colección de hojas informativas del NCI trata de una variedad de temas relacionados con el cáncer. Las hojas informativas se revisan y ponen al día de acuerdo a las investigaciones más recientes sobre el cáncer.

  8. The Zona Incerta Regulates Communication between the Superior Colliculus and the Posteromedial Thalamus: Implications for Thalamic Interactions with the Dorsolateral Striatum

    PubMed Central

    Watson, Glenn D.R.; Smith, Jared B.

    2015-01-01

    There is uncertainty concerning the circuit connections by which the superior colliculus interacts with the basal ganglia. To address this issue, anterograde and retrograde tracers were placed, respectively, into the superior colliculus and globus pallidus of Sprague-Dawley rats. In this two-tracer experiment, the projections from the superior colliculus terminated densely in the ventral zona incerta (ZIv), but did not overlap the labeled neurons observed in the subthalamic nucleus. In cases in which anterograde and retrograde tracers were placed, respectively, in sensory-responsive sites in the superior colliculus and posteromedial (POm) thalamus, the labeled projections from superior colliculus innervated the ZIv regions that contained the labeled neurons that project to POm. We also confirmed this colliculo–incertal–POm pathway by depositing a mixture of retrograde and anterograde tracers at focal sites in ZIv to reveal retrogradely labeled neurons in superior colliculus and anterogradely labeled terminals in POm. When combined with retrograde tracer injections in POm, immunohistochemical processing proved that most ZIv projections to POm are GABAergic. Consistent with these findings, direct stimulation of superior colliculus evoked neuronal excitation in ZIv and caused inhibition of spontaneous activity in POm. Collectively, these results indicate that superior colliculus can activate the inhibitory projections from ZIv to the POm. This is significant because it suggests that the superior colliculus could suppress the interactions between POm and the dorsolateral striatum, presumably to halt ongoing behaviors so that more adaptive motor actions are selected in response to unexpected sensory events. SIGNIFICANCE STATEMENT By demonstrating that the zona incerta regulates communication between the superior colliculus and the posteromedial thalamus, we have uncovered a circuit that partly explains the behavioral changes that occur in response to unexpected sensory stimuli. Furthermore, this circuit could explain why deep brain stimulation of the zona incerta is beneficial to patients who suffer from Parkinson's disease. PMID:26109669

  9. Use of Both Cumulus Cells’ Transcriptomic Markers and Zona Pellucida Birefringence to Select Developmentally Competent Oocytes in Human Assisted Reproductive Technologies

    PubMed Central

    2015-01-01

    Background Selection of the best oocyte for subsequent steps of fertilization and embryo transfer was shown to be the crucial step in human infertility treatment procedure. Oocyte selection using morphological criteria mainly Zona pellucida (ZP) has been the gold standard method in assisted reproductive technologies (ART) clinics, but this selection approach has limitations in terms of accuracy, objectivity and constancy. Recent studies using OMICs-based approaches have allowed the identification of key molecular markers that quantitatively and non-invasively predict the oocyte quality for higher pregnancy rates and efficient infertility treatment. These biomarkers are a valuable reinforcement of the morphological selection criteria widely used in in vitro fertilization (IVF) clinics. In this context, this study was designed to investigate the relationship between transcriptomic predictors of oocyte quality found by our group and the conventional morphological parameters of oocyte quality mainly the ZP birefringence. Results Microarray data revealed that 48 and 27 differentially expressed candidate genes in cumulus cells (CCs) were respectively overexpressed and underexpressed in the ZGP (Zona Good Pregnant) versus ZBNP (Zona Bad Non Pregnant) groups. More than 70% of previously reported transcriptomic biomarkers of oocyte developmental competence were confirmed in this study. The analysis of possible association between ZP birefringence versus molecular markers approach showed an absence of correlation between them using the current set of markers. Conclusions This study suggested a new integrative approach that matches morphological and molecular approaches used to select developmentally competent oocytes able to lead to successful pregnancy and the delivery of healthy baby. For each ZP birefringence score, oocytes displayed a particular CCs' gene expression pattern. However, no correlations were found between the 7 gene biomarkers of oocyte developmental potential and the ZP birefringence score. Further studies using larger lists of candidate markers are required to identify suitable genes that are highly correlated with the morphological criteria, and therefore able to reinforce the accuracy of oocyte selection and the effectiveness of infertility treatment. PMID:25923296

  10. Inhibitors of serine proteases decrease sperm penetration during porcine fertilization in vitro by inhibiting sperm binding to the zona pellucida and acrosome reaction.

    PubMed

    Beek, J; Nauwynck, H; Appeltant, R; Maes, D; Van Soom, A

    2015-11-01

    Serine proteases are involved in mammalian fertilization. Inhibitors of serine proteases can be applied to investigate at which point these enzymes exert their action. We selected two serine protease inhibitors, 4-(2-aminoethyl)benzenesulfonyl fluoride hydrochloride (AEBSF, 100 ?M) and soybean trypsin inhibitor (STI, 5 ?M) from Glycine max, via previous dose-response IVF experiments and sperm toxicity tests. In the present study, we evaluated how these inhibitors affect porcine fertilization in vitro as calculated on total fertilization rate, polyspermy rate, and the sperm number per fertilized oocyte of cumulus-intact, cumulus-free, and zona-free oocytes. In the control group (no inhibitor), these parameters were 86%, 49%, and 2.2 for cumulus-intact oocytes and 77%, 43%, and 2.2 for cumulus-free oocytes (6-hour gamete incubation period, 1.25 × 10(5) spermatozoa/mL). 4-(2-Aminoethyl)benzenesulfonyl fluoride hydrochloride and STI significantly reduced total fertilization and polyspermy rate in cumulus-intact and cumulus-free oocytes (P < 0.05). Total fertilization rates were respectively 65% and 53% (AEBSF) and 36% and 17% (STI). Inhibition rates were higher in cumulus-free oocytes than in cumulus-intact oocytes, indicating that inhibitors exerted their action after sperm passage through the cumulus. 4-(2-Aminoethyl)benzenesulfonyl fluoride hydrochloride but not STI reduced sperm binding to the ZP. The acrosome reaction was significantly inhibited by both inhibitors. Only 40.4% (AEBSF) and 11.4% (STI) of spermatozoa completed a calcium-induced acrosome reaction compared to 86.7% of spermatozoa in the control group. There was no effect on sperm binding or fertilization parameters in zona-free oocytes. In conclusion, sperm-zona binding and acrosome reaction were inhibited by serine protease inhibitors during porcine IVF. PMID:26303413

  11. The immune response and fertility of koalas (Phascolarctos cinereus) immunised with porcine zonae pellucidae or recombinant brushtail possum ZP3 protein.

    PubMed

    Kitchener, Anne L; Kay, David J; Walters, Bryan; Menkhorst, Peter; McCartney, Carmen A; Buist, Janine A; Mate, Karen E; Rodger, John C

    2009-10-01

    To evaluate the potential contraceptive effect of immunisation with zona pellucida antigens, 50 free-ranging koalas were immunised with either porcine zonae pellucidae (PZP), recombinant brushtail possum ZP3 (recBP-ZP3) or buffer, in complete Freund's adjuvant. A single booster immunisation in incomplete Freund's adjuvant was administered 3-5 months later. Where possible animals were recaptured, reproductive status was assessed and blood was collected at 1-3-month intervals for the next 33 months. Forty-three koalas were recaptured at least three times allowing reliable assessments of their fertility. Fourteen animals were observed never to have a pouch young. Of the remaining 29 animals the reproductive productivity of PZP treated females was reduced compared with control and recBP-ZP3 treated females, in terms of both total number of young produced, and failure to produce further young in females of proven fertility. One month after the initial immunisation, serum antigen-specific antibody titres were higher in animals immunised with PZP or recBP-ZP3 compared to controls, and reached a plateau by 4 months. Antibody against the relevant immunising antigen was also detected in ovarian follicular fluid, uterine fluid and vaginal secretions. Epitope analysis suggested that immune responses other than antibodies directed against the ZP3 amino acid sequence were responsible for mediating infertility. The results demonstrate that the fertility of female koalas can be compromised by immunisation against zona pellucida antigens. However, unlike in the eastern grey kangaroo and the brushtail possum, immunisation with bacterial recombinant brushtail possum ZP3 did not compromise fertility in the koala. PMID:19709753

  12. modelado y analisis del transporte del herbicida glifosato

    E-print Network

    2001-03-12

    imprescindibles para el estudio del transporte de agua y de sustancias ... fenómeno dependerá de la composición físico-química del suelo, en particular de su ..... ser considerado como un indicador de la representatividad de los datos

  13. UNIVERSIT DEGLI STUDI DI ROMA "LA SAPIENZA" DIPARTIMENTO DI SCIENZE DEL LIBRO E DEL DOCUMENTO

    E-print Network

    Di Pillo, Gianni

    UNIVERSIT� DEGLI STUDI DI ROMA "LA SAPIENZA" DIPARTIMENTO DI SCIENZE DEL LIBRO E DEL DOCUMENTO Prot del Dipartimento di Scienze del libro e del documento, Università degli Studi di Roma "La Sapienza

  14. Pruebas de Papanicolaou y del virus del papiloma humano (VPH)

    Cancer.gov

    Hoja informativa que describe los exámenes selectivos de detección del cáncer de cérvix, los cuales incluyen la prueba de Papanicolaou y la prueba de los virus del papiloma humano. La hoja informativa incluye también información acerca de las pautas de exámenes de detección del cáncer de cérvix.

  15. Instantánea del cáncer de tiroides

    Cancer.gov

    Información sobre las tendencias de incidencia, mortalidad y financiamiento del NCI sobre el cáncer de tiroides; así como ejemplos de actividades del NCI y adelantos en la investigación de este tipo de cáncer.

  16. Instantánea del cáncer de esófago

    Cancer.gov

    Información sobre las tendencias de incidencia, mortalidad y financiamiento del NCI sobre el cáncer de esófago; así como ejemplos de actividades del NCI y adelantos en la investigación de este tipo de cáncer.

  17. Instantánea del cáncer de pulmón

    Cancer.gov

    Información sobre las tendencias de incidencia, mortalidad y financiamiento del NCI sobre el cáncer de pulmón; así como ejemplos de actividades del NCI y adelantos en la investigación de este tipo de cáncer.

  18. Instantánea del cáncer de riñón

    Cancer.gov

    Información sobre las tendencias de incidencia, mortalidad y financiamiento del NCI sobre el cáncer de riñón; así como ejemplos de actividades del NCI y adelantos en la investigación de este tipo de cáncer.

  19. Instantánea del cáncer de endometrio

    Cancer.gov

    Información sobre las tendencias de incidencia, mortalidad y financiamiento del NCI sobre el cáncer de endometrio; así como ejemplos de actividades del NCI y adelantos en la investigación de este tipo de cáncer.

  20. Instantánea del cáncer de páncreas

    Cancer.gov

    Información sobre las tendencias de incidencia, mortalidad y financiamiento del NCI sobre el cáncer de páncreas; así como ejemplos de actividades del NCI y adelantos en la investigación de este tipo de cáncer.

  1. Instantánea del cáncer de estómago

    Cancer.gov

    Información sobre las tendencias de incidencia, mortalidad y financiamiento del NCI sobre el cáncer de estómago; así como ejemplos de actividades del NCI y adelantos en la investigación de este tipo de cáncer.

  2. Instantánea del cáncer de ovario

    Cancer.gov

    Información sobre las tendencias de incidencia, mortalidad y financiamiento del NCI sobre el cáncer de ovario; así como ejemplos de actividades del NCI y adelantos en la investigación de este tipo de cáncer.

  3. Instantánea del sarcoma de Kaposi

    Cancer.gov

    Información sobre las tendencias de incidencia, mortalidad y financiamiento del NCI sobre el sarcoma de Kaposi; así como ejemplos de actividades del NCI y adelantos en la investigación de este tipo de cáncer.

  4. Instantánea del cáncer de próstata

    Cancer.gov

    Información sobre las tendencias de incidencia, mortalidad y financiamiento del NCI sobre el cáncer de próstata; así como ejemplos de actividades del NCI y adelantos en la investigación de este tipo de cáncer.

  5. Instantánea del cáncer de vejiga

    Cancer.gov

    Información sobre las tendencias de incidencia, mortalidad y financiamiento del NCI sobre el cáncer de vejiga; así como ejemplos de actividades del NCI y adelantos en la investigación de este tipo de cáncer.

  6. Seroprevalence and risk factors of toxoplasmosis in cattle from extensive and semi-intensive rearing systems at Zona da Mata, Minas Gerais state, Southern Brazil

    PubMed Central

    2013-01-01

    Background Concerning the infection of humans by T. gondii, limited efforts have been directed to the elucidation of the role of horizontal transmission between hosts. One of the main routes of transmission from animals to humans occurs through the ingestion of raw or insufficiently cooked meat. However, even though the detection of T. gondii in meat constitutes an important short-term measure, control strategies can only be accomplished by a deeper understanding of the epidemiology of toxoplasmosis. The present study aimed to investigate the seroprevalence of toxoplasmosis in cattle from Zona da Mata, Minas Gerais, Brazil, and to identify associated risk factors, through an epidemiological investigation. Methods The animals studied (Bos indicus, breed Nelore or Gir) were reared in the Zona da Mata micro-region and killed at a commercial slaughterhouse at Juiz de Fora, Minas Gerais state. The animals came from 53 cattle farms with extensive (predominantly pasture feeding management) or semi-intensive (food management based on grazing, salt mineral and feed supplementation) rearing systems. Blood samples were collected from 1200 animals, and assigned to Indirect Fluorescent Antibody Test. Results When analyzing IgG anti-T.gondii we found an overall seroprevalence of 2.68%. In Brazil prevalences vary from 1.03% to 60%. Although in the present study, the seroprevalence per animal is considered low compared to those observed in other studies, we found out that of the 53 farms analyzed, 17 (34.69%) had one or more positive cattle. It is a considerable percentage, suggesting that the infection is well distributed through the Zona da Mata region. The results of the epidemiological investigation showed that the main risk factors of Toxoplasma gondii infection are related to animal management and to the definive host. There was a relationship between the number of seropositive cattle and the presence and number of resident cats, presence and number of stray cats, presence of cats walking freely, rat control by using cats and feed storage. Conclusion These results may contribute to the development of preventive strategies in Brazil and other developing countries were extensive and semi-intensive cattle rearing systems are very widespread and the efforts to control this important zoonotic disease have attained little success. PMID:23800302

  7. Determinacion de periodos fundamentales del suelo mediante vibraciones ambientales en el municipio de Humacao, Puerto Rico

    NASA Astrophysics Data System (ADS)

    Cintron Aponte, Rommel

    La tecnica de Nakamura ha sido utilizada a nivel mundial para determinar periodos fundamentales del suelo. La tecnica consiste en calcular y graficar cocientes espectrales H/V de vibraciones ambientales registradas sobre el suelo. Mediciones de vibraciones ambientales fueron tomadas en 151 lugares dentro del municipio de Humacao, localizado al este de Puerto Rico. Los datos se procesaron utilizando espectros de Fourier y espectros de potencia. La tecnica fue validada al compararla con los resultados de cocientes espectrales H/V de registros de sismos debiles y tambien con una modelacion numerica realizada con datos de un ensayo "downhole". Las graficas de los cocientes espectrales H/V fueron divididas en casos y grupos, los cuales dependen de la facilidad para identificar el periodo fundamental pico y amplitudes en frecuencias menores de 1 Hz, respectivamente. Los resultados obtenidos con ambos espectros fueron comparados y se concluye que los mismos se complementan para proveer resultados mas confiables. Se crearon mapas de periodos fundamentales, factores de amplitud, isoperiodos y clasificacion sismica de sitio. Los mapas de isoperiodos fueron realizados en las zonas mas pobladas sobre depositos de suelo. El mapa de periodos fundamentales del suelo mostro buena correlacion con la geologia local. El mapa de clasificacion sismica derivado de periodos de sitio fue comparado con el mapa de clasificacion sismica derivado de barrenos geotecnicos. El mapa de clasificacion obtenido de periodos puede sobreestimar un poco algunas clasificaciones del suelo. Sin embargo, este mapa puede proveer un estimado aproximado de la velocidad de onda de corte promedio del suelo hasta una profundidad de 100 pies (30 metros).

  8. The effect of pulsed 900-MHz GSM mobile phone radiation on the acrosome reaction, head morphometry and zona binding of human spermatozoa.

    PubMed

    Falzone, N; Huyser, C; Becker, P; Leszczynski, D; Franken, D R

    2011-02-01

    Several recent studies have indicated that radiofrequency electromagnetic fields (RF-EMF) have an adverse effect on human sperm quality, which could translate into an effect on fertilization potential. This study evaluated the effect of RF-EMF on sperm-specific characteristics to assess the fertilizing competence of sperm. Highly motile human spermatozoa were exposed for 1 h to 900-MHz mobile phone radiation at a specific absorption rate of 2.0 W/kg and examined at various times after exposure. The acrosome reaction was evaluated using flow cytometry. The radiation did not affect sperm propensity for the acrosome reaction. Morphometric parameters were assessed using computer-assisted sperm analysis. Significant reduction in sperm head area (9.2 ± 0.7 ?m² vs. 18.8 ± 1.4 ?m²) and acrosome percentage of the head area (21.5 ± 4% vs. 35.5 ± 11.4%) was reported among exposed sperm compared with unexposed controls. Sperm-zona binding was assessed directly after exposure using the hemizona assay. The mean number of zona-bound sperm of the test hemizona and controls was 22.8 ± 12.4 and 31.8 ± 12.8 (p < 0.05), respectively. This study concludes that although RF-EMF exposure did not adversely affect the acrosome reaction, it had a significant effect on sperm morphometry. In addition, a significant decrease in sperm binding to the hemizona was observed. These results could indicate a significant effect of RF-EMF on sperm fertilization potential. PMID:20236367

  9. Identification of distinctive interdomain interactions among ZP-N, ZP-C and other domains of zona pellucida glycoproteins underlying association of chicken egg-coat matrix

    PubMed Central

    Okumura, Hiroki; Sato, Takahiro; Sakuma, Rio; Fukushima, Hideaki; Matsuda, Tsukasa; Ujita, Minoru

    2015-01-01

    The vertebrate egg coat, including mammalian zona pellucida, is an oocyte-specific extracellular matrix comprising two to six zona pellucida (ZP) glycoproteins. The egg coat plays important roles in fertilization, especially in species-specific interactions with sperm to induce the sperm acrosome reaction and to form the block to polyspermy. It is suggested that the physiological functions of the egg coat are mediated and/or regulated coordinately by peptide and carbohydrate moieties of the ZP glycoproteins that are spatially arranged in the egg coat, whereas a comprehensive understanding of the architecture of vertebrate egg-coat matrix remains elusive. Here, we deduced the orientations and/or distributions of chicken ZP glycoproteins, ZP1, ZP3 and ZPD, in the egg-coat matrix by confocal immunofluorescent microscopy, and in the ZP1–ZP3 complexes generated in vitro by co-immunoprecipitation assays. We further confirmed interdomain interactions of the ZP glycoproteins by far-Western blot analyses of the egg-coat proteins and pull-down assays of ZP1 in the serum, using recombinant domains of ZP glycoproteins as probes. Our results suggest that the ZP1 and ZP3 bind through their ZP-C domains to form the ZP1–ZP3 complexes and fibrils, which are assembled into bundles through interactions between the repeat domains of ZP1 to form the ZP1–ZP3 matrix, and that the ZPD molecules self-associate and bind to the ZP1–ZP3 matrix through its ZP-N and ZP-C domains to form the egg-coat matrix. Based on these results, we propose a tentative model for the architecture of the chicken egg-coat matrix that might be applicable to other vertebrate ones. PMID:26106520

  10. Nevado del Huila, Columbia

    NASA Technical Reports Server (NTRS)

    2007-01-01

    Nevado del Huila Volcano in Colombia is actually a volcanic chain running north to south, capped by a glacier. With peaks ranging in height from 2,600 to 5,780 meters (8,530 to 18,960 feet), Nevado del Huila is a stratovolcano composed of alternating layers of hardened lava, solidified ash, and volcanic rocks. Its first recorded eruption occurred in the mid-sixteenth century. The long-dormant volcano erupted again in mid-April 2007. A few months before the eruption, the Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER) on NASA's Terra satellite captured this image of Nevado del Huila, on February 23, 2007. In this image, the bright white area just east of the central summit is ice. Immediately west of the summit are bare rocks, appearing as blue-gray. West of those rocks, white reappears, but this patch of white results from clouds hovering in the nearby valley. In the east, the colors turn to brown (indicating bare rock) and bright green (indicating vegetation). ASTER photographed Nevado del Huila near the end of a long phase of quietude. On April 17, 2007, local authorities recorded seismic activity associated with rock fracturing on the volcano's central summit, according to the ReliefWeb Website. Activity intensified the following day with an eruption and mudflows, forcing thousands of nearby residents to evacuate. As the Associated Press reported, the eruption caused avalanches and floods that wiped away both houses and bridges. It marked the volcano's first recorded eruption since the Spanish colonized the area five centuries earlier. NASA image created by Jesse Allen, using data provided courtesy of the NASA/GSFC/MITI/ERSDAC/JAROS, and U.S./Japan ASTER Science Team.

  11. Acerca del Centro para la Salud Mundial del NCI

    Cancer.gov

    El Centro para la Salud Mundial (CGH) coordina y fija las prioridades en las actividades que lleva a cabo el Instituto Nacional del Cáncer a nivel mundial. Su objetivo es avanzar la investigación mundial del cáncer y reducir las muertes causadas por esta enfermedad.

  12. La figura del 'Quijote' criollo en el teatro argentino de fines del siglo XIX y principios del XX

    E-print Network

    Cox, Victoria

    2000-04-01

    figura del "Quijote" criollo en el teatro argentino de fines del siglo XIX y principios del XX Victoria Cox Las piezas de teatro del género chico criollo constituyen un fiel reflejo de la sociedad argentina de principios de siglo. Es en sus escenarios... del establecimiento del estado nacional argentino y la entrada del país en el mercado mundial. El saínete Don Quijote en Buenos Aires de Eduardo Sojo (1885) tiene su origin en la zarzuela española. En esta obra Sojo realiza una sátira del momento...

  13. Dinamica del punto materiale Formule fondamentali

    E-print Network

    Peliti, Luca

    , sottoposto alla forza-peso, alla spinta di Archimede, e alla resistenza del mezzo, ha per espressione m d2 r spinta di Archimede (opposta al peso del fluido spostato). #12;Dinamica del punto materiale Formule

  14. Vacunas contra los virus del papiloma humano

    Cancer.gov

    Una hoja informativa acerca de las vacunas contra los virus del papiloma humano (VPH) para prevenir infecciones con ciertos tipos de VPH, los cuales son la causa principal del cáncer de cuello del útero o cérvix.

  15. CURRICULUM VITAE Roger del Moral--

    E-print Network

    del Moral, Roger

    -Mail: moral@u.washington.edu EDUCATION: 1968, Ph.D., Biology, U.C. Santa Barbara 1966, M. A., Botany, UCURRICULUM VITAE Roger del Moral-- Professor of Biology ADDRESS: University of Washington to available papers are provided): del Moral, R., J. E. Sandler & C. P. Muerdter. 2009. Spatial Factors Affect

  16. Phage display allows identification of zona pellucida-binding peptides with species-specific properties: novel approach for development of contraceptive vaccines for wildlife.

    PubMed

    Samoylova, Tatiana I; Cochran, Anna M; Samoylov, Alexandre M; Schemera, Bettina; Breiteneicher, Adam H; Ditchkoff, Stephen S; Petrenko, Valery A; Cox, Nancy R

    2012-12-31

    Multiple phage-peptide constructs, where the peptides mimic sperm epitopes that bind to zona pellucida (ZP) proteins, were generated via selection from a phage display library using a novel approach. Selections were designed to allow for identification of ZP-binding phage clones with potential species-specific properties, an important feature for wildlife oral vaccines as the goal is to control overpopulation of a target species while not affecting non-target species' reproduction. Six phage-peptide antigens were injected intramuscularly into pigs and corresponding immune responses evaluated. Administration of the antigens into pigs stimulated production of anti-peptide antibodies, which were shown to act as anti-sperm antibodies. Potentially, such anti-sperm antibodies could interfere with sperm delivery or function in the male or female genital tract, leading to contraceptive effects. Staining of semen samples collected from different mammalian species, including pig, cat, dog, bull, and mouse, with anti-sera from pigs immunized with ZP-binding phage allowed identification of phage-peptide constructs with different levels of species specificity. Based on the intensity of the immune responses and specificity of these responses in different species, two of the antigens with fusion peptide sequences GEGGYGSHD and GQQGLNGDS were recognized as the most promising candidates for development of contraceptive vaccines for wild pigs. PMID:23079080

  17. Methyl-?-Cyclodextrin Improves Sperm Capacitation Status Assessed by Flow Cytometry Analysis and Zona Pellucida-Binding Ability of Frozen/Thawed Bovine Spermatozoa.

    PubMed

    Águila, L; Arias, M E; Vargas, T; Zambrano, F; Felmer, R

    2015-12-01

    Mammalian sperm undergo a series of biochemical transformations in the female reproductive tract that are collectively known as capacitation. Cyclodextrins added to the sperm culture medium have been described to induce in vitro sperm capacitation, enabling its use in protein-free media. However, the additive capacitating effect of methyl-?-cyclodextrin (M?CD) in the medium containing bovine serum albumin (BSA) is unknown in the bovine species. In this study, we evaluated the effects of incubating frozen-thawed bovine spermatozoa in a BSA-containing medium supplemented with M?CD on different sperm quality and functional parameters. Sperm viability decreased with the addition of M?CD in a dose-dependent manner (p < 0.05), and DNA damage could be observed but only with the highest concentration of M?CD. However, pre-incubation of spermatozoa in M?CD-supplemented medium improved the capacitation status as assessed by the increase in plasma membrane fluidity, intracellular calcium concentration, induced acrosome reactivity and zona pellucida (ZP)-binding ability (p < 0.05). Thus, we conclude that M?CD supplementation is able to enhance the capacitation status of frozen-thawed bovine spermatozoa cultured in capacitation medium containing BSA and could result in a valid strategy for its application on artificial reproductive technologies such as in vitro fertilization or intracytoplasmic sperm injection. PMID:26395461

  18. The Postsynaptic Density 95/Disc-Large/Zona Occludens Protein Syntenin Directly Interacts with Frizzled 7 and Supports Noncanonical Wnt Signaling

    PubMed Central

    Luyten, Annouck; Mortier, Eva; Van Campenhout, Claude; Taelman, Vincent; Degeest, Gisèle; Wuytens, Gunther; Lambaerts, Kathleen; David, Guido; Bellefroid, Eric J.

    2008-01-01

    Wnt signaling pathways are essential for embryonic patterning, and they are disturbed in a wide spectrum of diseases, including cancer. An unresolved question is how the different Wnt pathways are supported and regulated. We previously established that the postsynaptic density 95/disc-large/zona occludens (PDZ) protein syntenin binds to syndecans, Wnt coreceptors, and known stimulators of protein kinase C (PKC)? and CDC42 activity. Here, we show that syntenin also interacts with the C-terminal PDZ binding motif of several Frizzled Wnt receptors, without compromising the recruitment of Dishevelled, a key downstream Wnt-signaling component. Syntenin is coexpressed with cognate Frizzled during early development in Xenopus. Overexpression and down-regulation of syntenin disrupt convergent extension movements, supporting a role for syntenin in noncanonical Wnt signaling. Syntenin stimulates c-jun phosphorylation and modulates Frizzled 7 signaling, in particular the PKC?/CDC42 noncanonical Wnt signaling cascade. The syntenin–Frizzled 7 binding mode indicates syntenin can accommodate Frizzled 7–syndecan complexes. We propose that syntenin is a novel component of the Wnt signal transduction cascade and that it might function as a direct intracellular link between Frizzled and syndecans. PMID:18256285

  19. Control del cáncer y salud mundial: noticia del Instituto Nacional del Cáncer (NCI)

    Cancer.gov

    En combinación con una reunión de alto nivel de las Naciones Unidas sobre enfermedades no transmisibles en países en vías de desarrollo, el doctor Harold Varmus, director del NCI, y el doctor Ted L. Trimble, del NCI, han publicado un comentario en Science

  20. Il logo del CNR the CNR logotype

    E-print Network

    Spinolo, Laura Valentina

    Il logo del CNR the CNR logotype #12;Il logo del CNR - the CNR logotype Consiglio Nazionale delle Ricerche National Research Council of Italy LOGORESTYLING:SILVESTROCALIGIURI-CNR #12;Il logo del CNR- nopqrstuvz ABCDEFGHILM- NOPQRSTUVZ #12;Il logo del CNR - the CNR logotype Utilizzo in orizzontale (da

  1. Control of phonatory onset and offset in Parkinson patients following deep brain stimulation of the subthalamic nucleus and caudal zona incerta.

    PubMed

    Karlsson, Fredrik; Blomstedt, Patric; Olofsson, Katarina; Linder, Jan; Nordh, Erik; van Doorn, Jan

    2012-08-01

    Laryngeal hypokinesia is a common symptom in Parkinson's disease (PD) that affects quality of life. Deep brain stimulation (DBS) is well recognized as a complementary method for treatment of motor symptoms in PD but the outcomes on patients' control over phonatory alternation have yet not been clearly elucidated. The present study examined the effect of subthalamic nucleus STN-DBS (n = 8, aged 51-72 yrs; median = 63 yrs) and caudal Zona incerta cZi-DBS (n = 8, aged 49-71 yrs; median = 61 yrs) on control of onset and offset of phonation in connected speech. The patients were evaluated in a preoperatively (Med ON, 1.5 times the ordinary Levodopa dose) and 12 months post-operatively (Med ON, ordinary Levodopa dose). The results provided evidence of a progressive reduction in the ability to manifest alternations between voicing and voiceless states in a reading task. Mean proportion produced with inappropriate voicing increased from 47.6% to 55.3% and from 62.9% to 68.6% of the total duration for the two groups of patients between Pre-op and Post-op, Stim OFF evaluations. The medial and final parts of the fricative were more affected than the initial part, indicating an increased voicing lead into the following vowel. We propose that this reduction in phonatory control is be due to either progression of the disease, an effect of reduced Levodopa dosage or a microlesional effect. Patients' proficiency in alternating between voiced and voiceless states in connected speech remained unaffected by both STN-DBS and cZi-DBS. PMID:22522070

  2. The Hinge Region of Bovine Zona Pellucida Glycoprotein ZP3 Is Involved in the Formation of the Sperm-Binding Active ZP3/ZP4 Complex

    PubMed Central

    Suzuki, Kaori; Tatebe, Nanami; Kojima, Sayuri; Hamano, Ayumi; Orita, Misaki; Yonezawa, Naoto

    2015-01-01

    The zona pellucida (ZP) surrounds the mammalian oocyte and mediates species-selective sperm-oocyte interactions. Bovine ZP consists of glycoproteins ZP2, ZP3, and ZP4. Neither ZP3 nor ZP4 alone shows inhibitory activity for the binding of sperm to the ZP; however, this activity is seen with the ZP3/ZP4 heterocomplex. Here, we constructed a series of bovine ZP3 mutants to identify the ZP4-binding site on ZP3. Each ZP3 mutant was co-expressed with ZP4 using a baculovirus-Sf9 cell expression system and examined for interaction with ZP4 as well as inhibitory activity for sperm-ZP binding. N-terminal fragment Arg-32 to Arg-160 of ZP3 interacted with ZP4 and inhibited sperm-ZP binding, whereas fragment Arg-32 to Thr-155 showed much weaker interaction with ZP4. Mutation of N-glycosylated Asn-146 to Asp in the N-terminal fragment Arg-32 to Glu-178 of ZP3 did not interrupt the interaction of this fragment with ZP4, but it did reduce the inhibitory activity of the complex for sperm-ZP binding. In contrast, mutation of N-glycosylated Asn-124 to Asp did not significantly reduce the activity. Taken together, these results suggest that one of the ZP4 binding sites exists in the flexible hinge region of ZP3 and that the N-glycosylation in this region is involved in the sperm binding. PMID:26610590

  3. Molecular adjuvant interleukin-33 enhances the antifertility effect of Lagurus lagurus zona pellucida 3 DNA vaccine administered by the mucosal route

    PubMed Central

    Tu, Y.X.; Li, X.P.; Kadir, Z.; Zhang, F.C.

    2013-01-01

    It has been shown that cytokines can act as molecular adjuvant to enhance the immune response induced by DNA vaccines, but it is unknown whether interleukin 33 (IL-33) can enhance the immunocontraceptive effect induced by DNA vaccines. In the present study, we explored the effects of murine IL-33 on infertility induced by Lagurus lagurus zona pellucida 3 (Lzp3) contraceptive DNA vaccine administered by the mucosal route. Plasmid pcD-Lzp3 and plasmid pcD-mIL-33 were encapsulated with chitosan to generate the nanoparticle chi-(pcD-Lzp3+pcD-mIL-33) as the DNA vaccine. Sixty female ICR mice, divided into 5 groups (n=12/group), were intranasally immunized on days 0, 14, 28, and 42. After intranasal immunization, the anti-LZP3-specific IgG in serum and IgA in vaginal secretions and feces were determined by ELISA. The results showed that chi-(pcD-Lzp3+pcD-mIL-33) co-immunization induced the highest levels of serum IgG, secreted mucosal IgA, and T cell proliferation. Importantly, mice co-immunized with chi-(pcD-Lzp3+pcD-mIL-33) had the lowest birth rate and mean litter size, which correlated with high levels of antibodies. Ovaries from infertile female mice co-immunized with chi-(pcD-Lzp3+pcD-mIL-33) showed abnormal development of ovarian follicles, indicated by atretic follicles and loss of oocytes. Our results demonstrated that intranasal delivery of the molecular adjuvant mIL-33 with chi-pcD-Lzp3 significantly increased infertility by enhancing both systemic and mucosal immune responses. Therefore, chi-(pcD-Lzp3+pcD-mIL-33) co-immunization could be a strategy for controlling the population of wild animal pests. PMID:24345916

  4. Case Study: del Amo Bioventing

    EPA Science Inventory

    The attached presentation discusses the fundamentals of bioventing in the vadose zone. The basics of bioventing are presented. The experience to date with the del Amo Superfund Site is presented as a case study.

  5. Impactos del Huracn Isaac en la calidad del agua en Luisiana con MODIS 250m

    E-print Network

    Gilbes, Fernando

    1 Impactos del Huracán Isaac en la calidad del agua en Luisiana con MODIS 250m Thais J. Alicea lluvias. Por tal razón se quiere estudiar la calidad del agua en el delta del río Mississippi antes imágenes en ENVI. Palabras clave: Calidad del agua, ENVI, Isaac, Luisiana, MODIS

  6. Infografía: beneficios y perjuicios de la prueba del PSA para la detección del cáncer de próstata

    Cancer.gov

    Infografía que muestra los beneficios y perjuicios de la prueba del PSA para la detección del cáncer de próstata, según estimaciones de dos estudios sobre exámenes de detección del cáncer de próstata.

  7. RESUM SEMINARI SOBRE EL PAPER DE LA PAGESIA EN LA GESTI DEL TERRITORI AL DELTA DEL LLOBREGAT.

    E-print Network

    Politècnica de Catalunya, Universitat

    RESUM SEMINARI SOBRE EL PAPER DE LA PAGESIA EN LA GESTI� DEL TERRITORI AL DELTA DEL LLOBREGAT. De un paper menys destacat en la gestió del Delta del Llobregat, sobretot en tot allò relacionat amb el que el futur del sector agrari del Delta del Llobregat sigui massa esperançador. El Delta, situat en

  8. Estudio numerico y experimental del proceso de soldeo MIG sobre la aleacion 6063--T5 utilizando el metodo de Taguchi

    NASA Astrophysics Data System (ADS)

    Meseguer Valdenebro, Jose Luis

    Electric arc welding processes represent one of the most used techniques on manufacturing processes of mechanical components in modern industry. The electric arc welding processes have been adapted to current needs, becoming a flexible and versatile way to manufacture. Numerical results in the welding process are validated experimentally. The main numerical methods most commonly used today are three: finite difference method, finite element method and finite volume method. The most widely used numerical method for the modeling of welded joints is the finite element method because it is well adapted to the geometric and boundary conditions in addition to the fact that there is a variety of commercial programs which use the finite element method as a calculation basis. The content of this thesis shows an experimental study of a welded joint conducted by means of the MIG welding process of aluminum alloy 6063-T5. The numerical process is validated experimentally by applying the method of finite element through the calculation program ANSYS. The experimental results in this paper are the cooling curves, the critical cooling time t4/3, the weld bead geometry, the microhardness obtained in the welded joint, and the metal heat affected zone base, process dilution, critical areas intersected between the cooling curves and the curve TTP. The numerical results obtained in this thesis are: the thermal cycle curves, which represent both the heating to maximum temperature and subsequent cooling. The critical cooling time t4/3 and thermal efficiency of the process are calculated and the bead geometry obtained experimentally is represented. The heat affected zone is obtained by differentiating the zones that are found at different temperatures, the critical areas intersected between the cooling curves and the TTP curve. In order to conclude this doctoral thesis, an optimization has been conducted by means of the Taguchi method for welding parameters in order to obtain an improvement on mechanical properties in aluminum metal joint. Los procesos de soldadura por arco electrico representan unas de las tecnicas mas utilizadas en los procesos de fabricacion de componentes mecanicos en la industria moderna. Los procesos de soldeo por arco se han adaptado a las necesidades actuales, haciendose un modo de fabricacion flexible y versatil. Los resultados obtenidos numericamente en el proceso de soldadura son validados experimentalmente. Los principales metodos numericos mas empleados en la actualidad son tres, metodo por diferencias finitas, metodos por elementos finitos y metodo por volumenes finitos. El metodo numerico mas empleado para el modelado de uniones soldadas, es el metodo por elementos finitos, debido a que presenta una buena adaptacion a las condiciones geometricas y de contorno ademas de que existe una diversidad de programas comerciales que utilizan el metodo por elementos finitos como base de calculo. Este trabajo de investigacion presenta un estudio experimental de una union soldada mediante el proceso MIG de la aleacion de aluminio 6063-T5. El metodo numerico se valida experimentalmente aplicando el metodo de los elementos finitos con el programa de calculo ANSYS. Los resultados experimentales obtenidos son: las curvas de enfriamiento, el tiempo critico de enfriamiento t4/3, geometria del cordon, microdurezas obtenidas en la union soldada, zona afectada termicamente y metal base, dilucion del proceso, areas criticas intersecadas entre las curvas de enfriamiento y la curva TTP. Los resultados numericos son: las curvas del ciclo termico, que representan tanto el calentamiento hasta alcanzar la temperatura maxima y un posterior enfriamiento. Se calculan el tiempo critico de enfriamiento t4/3, el rendimiento termico y se representa la geometria del cordon obtenida experimentalmente. La zona afectada termicamente se obtiene diferenciando las zonas que se encuentran a diferentes temperaturas, las areas criticas intersecadas entre las curvas de enfriamiento y la curva TTP. Para finalizar el trabajo de investigacion se ha realizado un

  9. El libro del Relogio del Palacio de las Horas

    NASA Astrophysics Data System (ADS)

    Morales, J. D.

    2009-08-01

    This paper resume the investigation entitled ``El libro del Relogio del Palacio de las Horas''. That consist in an edition of the original text of the book of the Clock of the Palace of the Hours from the Books of the knowledge of Astronomy of Alfonso X (Manuscript 156, Complutense University). And a description of the astronomical functionality of the Clock of the Palace of the Hours. It includes a geometric description of the positional astronomy on which the operation of the Palace is based.

  10. Temas y rumbos del teatro rural hispanoamericano del siglo XX.

    E-print Network

    Neglia, Erminio G.

    1971-10-01

    pérdida del campo y de la deshonra de su familia: "¡Señor! ¡Señor! ¡Qué le habré hecho a la suerte pa que me trate así! . . .", exclama don Zoilo al final del primer acto.6 Su pesimismo proviene de la conciencia de no merecer tal trata miento de la... artístico de dos escritores argentinos que han situado dramas de temas griegos y bíblicos en el campo pampeano. FALL 1971 55 Ellos son Juan Oscar Ponferrada y Leopoldo Marechal. En El trigo es de Dios, Ponferrada combina los elementos bíblicos (la...

  11. EL ROL DEL GNERO DENTRO DEL PROCESO DE APRENDIZAJE COLABORATIVO

    E-print Network

    Guerrero, Luis

    de sexo y la forma en que esto afecta las actividades colaborativas. En el presente trabajo se describen los resultados de un experimento desarrollado con el fin de establecer que la diferencia de sexo]. Varios estudios también han demostrado que las diferencias de sexo en el uso del computador están

  12. Base de datos integral del NCI - PDQ®

    Cancer.gov

    Base de datos del NCI que contiene la información más reciente sobre prevención, exámenes de detección y tratamiento del cáncer, así como sumarios sobre genética, cuidados de apoyo y medicina complementaria y alternativa, y estudios clínicos.

  13. Instantánea del cáncer de seno (mama)

    Cancer.gov

    Información sobre las tendencias de incidencia, mortalidad y financiamiento del NCI sobre el cáncer de seno (mama); así como ejemplos de actividades del NCI y adelantos en la investigación de este tipo de cáncer.

  14. Instantánea del cáncer de cuello uterino

    Cancer.gov

    Información sobre las tendencias de incidencia, mortalidad y financiamiento del NCI sobre el cáncer de cuello uterino; así como ejemplos de actividades del NCI y adelantos en la investigación de este tipo de cáncer.

  15. Grados de comprobación científica del PDQ®

    Cancer.gov

    Los sumarios del PDQ de información sobre el cáncer incluyen denominaciones del grado de comprobación científica con el propósito de ayudar al lector a entender la solidez de las pruebas que sustentan el uso de intervenciones o enfoques específicos.

  16. El té y la prevención del cáncer

    Cancer.gov

    Hoja informativa que resume los resultados de estudios realizados sobre el té y la prevención del cáncer. Incluye información sobre los ingredientes del té y las consideraciones de seguridad sobre el consumo de esta bebida.

  17. Aprendizajes del Informe Especial (SREX) del IPCC Desastres en Amrica Latina y el Caribe

    E-print Network

    Aprendizajes del Informe Especial (SREX) del IPCC Desastres en América Latina y el Caribe: La Especial (SREX) del IPCC, disponible en www.cdkn.org/srex. Toda la correspondencia debe ser dirigida a: Dr niveles de decisión en América Latina y el Caribe? 16 Glosario de Términos para el SREX del IPCC 19 Guía

  18. Rafael Molina Bases del filtro de Kalman 1 Bases del filtro de Kalman

    E-print Network

    Granada, Universidad de

    Rafael Molina Bases del filtro de Kalman 1 Bases del filtro de Kalman Rafael Molina Soriano Depto Ciencias de la Computación e IA Universidad de Granada #12;Rafael Molina Bases del filtro de Kalman 2 Contenidos ! Introducción. ! El filtro de Kalman " Modelo del sistema " Modelo de medida " Formulación de la

  19. Arquitectura del Sistema de Gestin del ancho de Banda y Proteccin (SGBP) para entornos de redes

    E-print Network

    Ortega, Eusebi Calle

    Arquitectura del Sistema de Gestión del ancho de Banda y Protección (SGBP) para entornos de redes}@eia.udg.es Resumen. En el presente artículo se describe la arquitectura de un sistema inte- gral de gestión del ancho 4 detalla la arquitectura propuesta del sistema. Por último, se presentan las conclusiones y futuros

  20. Manejo seguro del meln fresco

    E-print Network

    Bohnhoff, David

    Manejo seguro del melón fresco l melón es una buena fuente de vitamina A y vitamina C y es. Los productos frescos proveen vitaminas, min- erales y fibra para ayudar a man- tener su cuerpo sano- tas y verduras por día. Una porción de melón fresco equivale a 1 /2 taza de melón cortado en cubitos

  1. Pgina 1 de 4 Planificacin Anticipada de Cuidados Mdicos del

    E-print Network

    Tipple, Brett

    : (_____) ______________________ Celular: (_____) ________________________________ Fecha de nacimiento: __________________________ C. Mi: (_____) _____________________ Celular: (_____) _________________________ Teléfono del trabajo: (_______) ________________________ A. Sin casa: (_____) ______________________ Celular: (______) ________________________ Teléfono del trabajo

  2. Self Interacting Markov chains P. Del Moral

    E-print Network

    Del Moral , Pierre

    Self Interacting Markov chains P. Del Moral Centre INRIA Bordeaux-Sud Ouest S´eminaire de l works with Bercu & Doucet, HAL-INRIA preprints (2008). P. Del Moral (INRIA Bordeaux) INRIA Centre interacting Markov chains 4 Interacting MCMC models P. Del Moral (INRIA Bordeaux) INRIA Centre Bordeaux

  3. Self Interacting Markov chains P. Del Moral

    E-print Network

    Del Moral , Pierre

    Self Interacting Markov chains P. Del Moral Centre INRIA Bordeaux-Sud Ouest Mathematical Institute works with Bercu & Doucet, HAL-INRIA preprints (2008). P. Del Moral (INRIA Bordeaux) INRIA Centre interacting Markov chains 4 Interacting MCMC models P. Del Moral (INRIA Bordeaux) INRIA Centre Bordeaux

  4. Self Interacting Markov chains P. Del Moral

    E-print Network

    Del Moral , Pierre

    Self Interacting Markov chains P. Del Moral Centre INRIA Bordeaux-Sud Ouest Stochastic Analysis of joint works with Bercu & Doucet, HAL-INRIA preprints (2008). P. Del Moral (INRIA Bordeaux) INRIA Centre interacting Markov chains 4 Interacting MCMC models P. Del Moral (INRIA Bordeaux) INRIA Centre Bordeaux

  5. EVOLUZIONE-WEB -1 -Evoluzione del Web

    E-print Network

    De Antonellis, Valeria

    EVOLUZIONE-WEB - 1 - Evoluzione del Web (fonte prof. Polillo) #12;- 2 - L'evoluzione del web EVOLUZIONE-WEB · Dal primo sito Web (1991) il Web è in continua crescita, e in continua evoluzione tecnologia, il mercato, i comportamenti delle persone · Le fasi della storia del Web: Web 1.0, Web 2.0, il

  6. Gulliver dormido de Samuel Rovinski: Una parodia del discurso del poder

    E-print Network

    Rojas, Mario A.

    1990-10-01

    dormido de Samuel Rovinski: Una parodia del discurso del poder Mario A. Rojas En este estudio nos proponemos especificar, semióticamente, los mecanismos encubiertos del discurso del poder y el modo paródico con que en Gulliver dormido Rovinski los... naturaleza subversiva (la farsa desconstruye el delicado tono y estilo de la comedia) que refleja el propio espíritu del dramaturgo quien privilegia la farsa como un efectivo medio para satirizar su realidad inmediata.4 El subtítulo, finalmente, nos...

  7. Informe del Consejo Rector del CSIC del 30092014 El Consejo Rector se celebr el 30 de septiembre de 2014 y la sesin se inici con un amplio y

    E-print Network

    Fitze, Patrick

    1 Informe del Consejo Rector del CSIC del 30092014 El Consejo Rector se celebró el 30 de septiembre de 2014 y la sesión se inició con un amplio y detallado informe del programa de actividades en torno al 75 aniversario del CSIC, cuyo acto central se celebrará el 24

  8. INTRODUCCIN A LA ESTADSTICA APLICADA EN LA QUMICA Los institutos de Qumica Avanzada de Catalua (IQAC) y del Diagnstico Ambiental y Estudios del Agua (IDAEA) del CSIC

    E-print Network

    (IQAC) y del Diagnóstico Ambiental y Estudios del Agua (IDAEA) del CSIC ofrecen la posibilidad de datos: diseño, grabación, exportación. 3.Control de calidad de la información contenida en una base de

  9. EL ESTUDIO DEL PLUMBISMO EN DOANA Y OTROS HUMEDALES ANDALUCES

    E-print Network

    Figuerola, Jordi

    Radiografía de muestras de suelo de la Laguna de Medina #12;2 #12;3 Investigador responsable: Andy J. Green acuta (Mateo et al., #12;6 1998). También se estudió la densidad de plomo en los suelos de las zonas

  10. COLOMBIA: El IV Festival del Nuevo Teatro

    E-print Network

    Gonzá lez, Patricia E.

    1980-10-01

    : El IV Festival del Nuevo Teatro PATRICIA GONZÁLEZ Con la participación de 22 grupos, y la intervención de cinco delegaciones extranjeras, se llevó a cabo el IV Festival Nacional del Nuevo Teatro Colombiano organizado por la Corporación Colombiana... que luego se elabora a base de ideas, sugerencias, improvisaciones y analogías. Es siempre un texto abierto que sufre grandes transformaciones en el proceso de montaje, y aún luego con la participación del público. 80 LATIN AMERICAN THEATRE REVIEW...

  11. Cirugía de los trastornos del comportamiento: el estado del arte

    PubMed Central

    Yampolsky, Claudio; Bendersky, Damián

    2014-01-01

    Introducción: La cirugía de los trastornos del comportamiento (CTC) se está convirtiendo en un tratamiento más común desde el desarrollo de la neuromodulación. Métodos: Este artículo es una revisión no sistemática de la historia, indicaciones actuales, técnicas y blancos quirúrgicos de la CTC. Dividimos su historia en 3 eras: la primera comienza en los inicios de la psicocirugía y termina con el desarrollo de las tícnicas estereotácticas, cuando comienza la segunda era. Ésta se caracteriza por la realización de lesiones estereotácticas. Nos encontramos transitando la tercera era, que comienza cuando la estimulación cerebral profunda (ECP) comienza a ser usada en CTC. Resultados: A pesar de los errores graves cometidos en el pasado, hoy en día, la CTC está renaciendo. Los trastornos psiquiátricos que se más frecuentemente se tratan con cirugía son: depresión refractaria, trastorno obsesivo-compulsivo y síndrome de Tourette. Además, algunos pacientes con agresividad fueron tratados quirúrgicamente. Hay varios blancos estereotácticos descriptos para estos trastornos. La estimulación vagal puede ser usada también para depresión. Conclusión: Los resultados de la ECP en estos trastornos parecen alentadores. Sin embargo, se necesitan más estudios randomizados para establecer la efectividad de la CTC. Debe tenerse en cuenta que una apropiada selección de pacientes nos ayudará a realizar un procedimiento más seguro así como también a lograr mejores resultados quirúrgicos, conduciendo a la CTC a ser más aceptada por psiquiatras, pacientes y sus familias. Se necesita mayor investigación en varios temas como: fisiopatología de los trastornos del comportamiento, indicaciones de CTC y nuevos blancos quirúrgicos. PMID:25165612

  12. PARAULES DEL RECTOR DE LA UPF EN L'ACTE DE CELEBRACI DEL NADAL

    E-print Network

    1 PARAULES DEL RECTOR DE LA UPF EN L'ACTE DE CELEBRACIÓ DEL NADAL 17 de Desembre del 2014 Bon dia'acabar. Per tant, us desitjo un bon Nadal (el millor de la vostra vida, si és possible). I ara, mentre Pompeu Fabra Nadal 2014. Si ens interessen les universitats, arribarem molt lluny. I si les universitats

  13. Control del dolor: Apoyo para las personas con cáncer

    Cancer.gov

    Libro sobre el control del dolor en pacientes con cáncer. Cubre los métodos y medicinas, así como los efectos físicos y emocionales del dolor. Es una adaptación cultural para el público de habla hispana del libro en inglés Pain Control.

  14. La generación de 1924: El dilema del realismo

    E-print Network

    Dauster, Frank

    1985-04-01

    preocupaciones existenciales visibles en la poesía del autor: la autenticidad individual, la relatividad, el dilema solipsista. Lo fascinante es que las dos obras están concebidas dentro del teatro realista; son como variantes a la temática consabida del lío...

  15. Seis estrenos del teatro argentino en 1976

    E-print Network

    Martí nez, Martha

    1978-04-01

    Segundo tiempo de Ricardo Halac. Podríamos decir, usando la misma metáfora del título, que Ricardo Halac, al igual que Talesnik, quiere entrar con esta obra en un segundo tiempo. Halac trata de filtrar la realidad a través del microcosmos de una pareja...

  16. Investigación sobre la detección del cáncer

    Cancer.gov

    De acuerdo con un estudio en el que participaron más de un millón de mujeres, los investigadores del NCI han determinado que el resultado negativo de una prueba para la detección del VPH proporciona mayor certeza o seguridad frente a riesgos futuros de cáncer de cuello uterino que una prueba de Pap.

  17. Festival Report: Festival del Sur '98

    E-print Network

    Má rquez Montes, Carmen

    1999-04-01

    noche temática con dos espectáculos, el de los cubanos Galiano 108 Federico-La Habana-Lorca y el del chileno Franklin Caicedo Lorca y sus amigos poetas; asimismo, se proyectaron varios vídeos sobre su vida y montajes emblemáticos de sus textos, tales... veces hacían difícil la comprensión del texto. Todo ello redundó en crear una atmósfera asfixiante y la repulsión del público ante esta lucha entre los sexos y las clases sociales. Desde Bolivia vino Amalilef Teatro con Jamás diré adiós, un nuevo...

  18. Balance del año teatral 1972 en Lima.

    E-print Network

    Cajiao Salas, Teresa

    1974-10-01

    ofrecer su programa académico regular, el TUSM organiza y mantiene a lo largo del año en su local de Jirón Lampa 833, ciclos de cine-teatro, foros, conferencias, exposiciones, homenajes y cursos gratuitos de teatro. El más importante de los homenajes... Popular César Valle jo. Es de lamentar, sin embargo, la vida efímera de la mayoría de estos conjuntos. En el curso del lustro 1967-1972, han aparecido y desaparecido diversos conjuntos, como ya hemos comentado, en razón principal mente, del problema...

  19. El teatro argentino del año 2000 y el teatro del futuro

    E-print Network

    Pellettieri, Osvaldo

    2000-10-01

    primordiales el manejo de una utopía fundamental: la destrucción de los modelos finiseculares, el cosmopolitismo, el culto a la originalidad. En esa concepción, el teatro era considerado un hecho didáctico básicamente testimonial (Pellettieri, 1990). Esta... juicio, ya no pretendía la ruptura del sistema teatral anterior, sino que, desde su interior, proponía una nueva forma de hacer teatro sin desconocer los modelos del pasado. La recontextualización y refuncionalización del discurso moderno se construían...

  20. Calcio y la prevención del cáncer

    Cancer.gov

    Hoja informativa que resume los resultados de estudios sobre el calcio y la prevención del cáncer. Incluye información sobre las recomendaciones dietéticas para calcio y la cantidad de calcio en los alimentos y en complementos de calcio.

  1. Tratamiento del cáncer sin daño al corazón

    Cancer.gov

    Investigadores de los campos de oncología y de cardiología están trabajando para encontrar formas de impedir, manejar y posiblemente aun revertir los efectos secundarios cardiovasculares de ciertas terapias del cáncer.

  2. UNIVERSIDAD SIMON BOLIVAR SEDE DEL LITORAL

    E-print Network

    Vásquez, Carlos

    UNIVERSIDAD SIMON BOLIVAR SEDE DEL LITORAL ESPECIALIZACIÓN EN TELECOMUNICACIONES DECANATO DE redes inteligentes II.- CONTENIDO PROGRAMATICO: Tema N° 1: ORGANIZACIÓN DE LAS REDES DE TELECOMUNICACIONES Información sobre el concepto de red. Formas de interconexión de los conmutadores. Plan básico de

  3. UNIVERSIDAD SIMON BOLIVAR SEDE DEL LITORAL

    E-print Network

    Vásquez, Carlos

    UNIVERSIDAD SIMON BOLIVAR SEDE DEL LITORAL ESPECIALIZACIÓN EN TELECOMUNICACIONES DECANATO DE Digitales Plesiócronas. Jerarquías europeas y americanas. Jerarquías Digitales Síncronas SDH y SONET. Redes Digitales. Administración de redes. #12;III.- BIBLIOGRAFIA: LIBRO TEXTO: 1.- SKLAR, Bernard. Digital

  4. UNIVERSIDAD SIMON BOLIVAR SEDE DEL LITORAL

    E-print Network

    Vásquez, Carlos

    datos, fibras ópticas, Sistemas PABX, Enlaces de microondas, Tecnología satelital y tecnología celular. Utilización del analizador de constelación. Tema N°9. Transmisión celular móvil GSM Estudio de herramientas de

  5. JORNADAS SOBRE LOS PROBLEMAS DEL MILENIO

    E-print Network

    Rotger, Víctor

    ´iculos. Me sugiri´o que a lo mejor podr´ia introducirme en la teor´ia de n´umeros a trav´es del estudio de~neros del grupo de teor´ia de n´umeros de la Universitat Polit`ecnica de Catalunya, la Universitat de ecuaciones diof´anticas. Y ese juego se lleva practicando desde hace muchos siglos, sin duda mucho antes que

  6. Informacin general Frecuencia del curso: Bienal

    E-print Network

    Información general Frecuencia del curso: Bienal Próxima Convocatoria: 2016 Coordinadora: Dra. Rosario Gonzalez Muñiz Año en el cual se impartió el curso por primera vez: 1986 Número de veces que se ha impartido el curso: 17 Secretaria del curso: Instituto de Química Médica (CSIC) Telf: 91-562 29 00 Fax: 91

  7. Direccin del Curso Jose Luis Jord Moret

    E-print Network

    Dirección del Curso Jose Luis Jordá Moret Marta Feliz Rodríguez Instituto de Tecnología Química (ITQ, UPV-CSIC) Secretaría Técnica del Curso Instituto de Tecnología Química (UPV-CSIC) Campus de la UPV Av. de los Naranjos s/n 46022 Valencia (España) Contacto http://cursositq.blogs.upv.es/ Curso de

  8. Gonadal dysgenesis in del (18p) syndrome

    SciTech Connect

    Telvi, L.; Ion, A.; Fouquet, F.

    1995-07-17

    We report on a girl with syndromal gonadal dysgenesis and a de novo del (18p). Genetic factors controlling gonadal development are located not only on the X chromosome, but also on autosomes. The present case suggests that one of these genes is situated on 18p. We conclude that patients with del (18p) syndrome should be evaluated for gonadal dysgenesis. 16 refs., 3 figs.

  9. Angiotensin II triggers expression of the adrenal gland zona glomerulosa-specific 3?-hydroxysteroid dehydrogenase isoenzyme through de novo protein synthesis of the orphan nuclear receptors NGFIB and NURR1.

    PubMed

    Ota, Takumi; Doi, Masao; Yamazaki, Fumiyoshi; Yarimizu, Daisuke; Okada, Kazuki; Murai, Iori; Hayashi, Hida; Kunisue, Sumihiro; Nakagawa, Yuuki; Okamura, Hitoshi

    2014-10-01

    The 3?-hydroxysteroid dehydrogenase (3?-HSD) is an enzyme crucial for steroid synthesis. Two different 3?-HSD isoforms exist in humans. Classically, HSD3B2 was considered the principal isoform present in the adrenal. However, we recently showed that the alternative isoform, HSD3B1, is expressed specifically within the adrenal zona glomerulosa (ZG), where aldosterone is produced, raising the question of why this isozyme needs to be expressed in this cell type. Here we show that in both human and mouse, expression of the ZG isoform 3?-HSD is rapidly induced upon angiotensin II (AngII) stimulation. AngII is the key peptide hormone regulating the capacity of aldosterone synthesis. Using the human adrenocortical H295R cells as a model system, we show that the ZG isoform HSD3B1 differs from HSD3B2 in the ability to respond to AngII. Mechanistically, the induction of HSD3B1 involves de novo protein synthesis of the nuclear orphan receptors NGFIB and NURR1. The HSD3B1 promoter contains a functional NGFIB/NURR1-responsive element to which these proteins bind in response to AngII. Knockdown of these proteins and overexpression of a dominant negative NGFIB both reduce the AngII responsiveness of HSD3B1. Thus, the AngII-NGFIB/NURR1 pathway controls HSD3B1. Our work reveals HSD3B1 as a new regulatory target of AngII. PMID:25092869

  10. Calidad de Imagen del Telescopio UNAM212

    NASA Astrophysics Data System (ADS)

    Cobos, F. J.; Teiada de Vargas, C.

    1987-05-01

    El telescopio UNAM2l2, del Observatorio Astronómico Nacional, situado en la Sierra de San Pedro Mártir (Baja California, México), cumplira en un futuro muy cercano siete años de uso para fines de investigación astronómica. Aunque en este tiempo no se ha efectuado un estudio sistemático acerca de su comportamiento óptico y de los factores que influyen en la calidad de las imágenes, se han realizado pruebas diversas, estudios parciales y reuniones especificas, cuyos resultados no siempre se han difundido ampliamente y generalmente no se han presentado por escrito. Es por ello que hemos creido necesario intentar una recopilación de la información existente para poder con ella establecer un diagnóstjco que, aunque no sea definitivo, sirva de base para futuros trabajos tendientes a optimizar el comportamiento óptico del telescopio. Es evidente que un buen número de las conclusiones que se presentan son resultado del trabajo de muchas personas ó de esfuerzos colectivos. Asimismo, hemos tratado de localizar información bibliográfica que pueda ser de utilidad. Nuestro objetivo primordial ha consistido en centrarnos en la óptica del telescopio y su calidad, pero también se han considerado otros aspectos que puedan afectar las imágenes obtenidas tales como: celda del primario, `seeing' local y externo, flexiones posibles en la estructura mecánica del telescopio, etc.

  11. REGLAMENTO DE LA LEY FEDERAL DEL DERECHO DE AUTOR CMARA DE DIPUTADOS DEL H. CONGRESO DE LA UNIN

    E-print Network

    REGLAMENTO DE LA LEY FEDERAL DEL DERECHO DE AUTOR CÁMARA DE DIPUTADOS DEL H. CONGRESO DE LA UNIÓN LA LEY FEDERAL DEL DERECHO DE AUTOR Nuevo Reglamento publicado en el Diario Oficial de la Federación expedir el siguiente REGLAMENTO DE LA LEY FEDERAL DEL DERECHO DE AUTOR TÍTULO I DISPOSICIONES GENERALES

  12. Del carnaval como 'metáfora' al teatro de carnaval

    E-print Network

    Remedi, Gustavo

    2001-04-01

    más productiva de visualizar el teatro del carnaval, y en general, la práctica teatral en la actualidad. Actuación de la Anti-Murga BCG en el tablado "El Monumental del Control" (Montevideo, 1988). Video del autor. 130 LATIN AMERICAN THEATRE REVIEW... todo espectáculo público. Su carácter 140 LATIN AMERICAN THEATRE REVIEW «if^^PW: Actuación de la Anti-Murga BCG en el tablado "El Monumental del Control" (Montevideo, 1988). Video del autor. aparentemente hedonista o lúdico los pone en la vereda de...

  13. Intertextual Sexual Politics: Illness and Desire in Enrique Gomez Carrillo's "Del amor", "del dolor y del vicio" and Aurora Caceres's "La rosa muerta"

    ERIC Educational Resources Information Center

    LaGreca, Nancy

    2012-01-01

    This study explores the intertextuality between Aurora Caceres's "La rosa muerta" (1914) and the novel "Del amor, del dolor y del vicio" (1898) by her ex-husband, Enrique Gomez Carrillo. Caceres strategically mentions Gomez Carrillo's novel in "La rosa muerta" to invite a reading of her work in dialogue with his. Both narratives follow the sexual…

  14. Vascular Endothelial Tight Junctions and Barrier Function Are Disrupted by 15(S)-Hydroxyeicosatetraenoic Acid Partly via Protein Kinase C?-mediated Zona Occludens-1 Phosphorylation at Threonine 770/772*

    PubMed Central

    Chattopadhyay, Rima; Dyukova, Elena; Singh, Nikhlesh K.; Ohba, Motoi; Mobley, James A.; Rao, Gadiparthi N.

    2014-01-01

    Disruption of tight junctions (TJs) perturbs endothelial barrier function and promotes inflammation. Previously, we have shown that 15(S)-hydroxyeicosatetraenoic acid (15(S)-HETE), the major 15-lipoxygenase 1 (15-LO1) metabolite of arachidonic acid, by stimulating zona occludens (ZO)-2 tyrosine phosphorylation and its dissociation from claudins 1/5, induces endothelial TJ disruption and its barrier dysfunction. Here, we have studied the role of serine/threonine phosphorylation of TJ proteins in 15(S)-HETE-induced endothelial TJ disruption and its barrier dysfunction. We found that 15(S)-HETE enhances ZO-1 phosphorylation at Thr-770/772 residues via PKC?-mediated MEK1-ERK1/2 activation, causing ZO-1 dissociation from occludin, disrupting endothelial TJs and its barrier function, and promoting monocyte transmigration; these effects were reversed by T770A/T772A mutations. In the arteries of WT mice ex vivo, 15(S)-HETE also induced ZO-1 phosphorylation and endothelial TJ disruption in a PKC? and MEK1-ERK1/2-dependent manner. In line with these observations, in WT mice high fat diet feeding induced 12/15-lipoxygenase (12/15-LO) expression in the endothelium and caused disruption of its TJs and barrier function. However, in 12/15-LO?/? mice, high fat diet feeding did not cause disruption of endothelial TJs and barrier function. These observations suggest that the 12/15-LO-12/15(S)-HETE axis, in addition to tyrosine phosphorylation of ZO-2, also stimulates threonine phosphorylation of ZO-1 in the mediation of endothelial TJ disruption and its barrier dysfunction. PMID:24338688

  15. Extensión del Formalismo de Orbitales de Defecto Cuántico al tratamiento del efecto Stark (SQDO).

    NASA Astrophysics Data System (ADS)

    Menéndez, J. M.; Martín, I.; Velasco, A. M.

    El estudio experimental de las interacciones de átomos Rydberg altamente excitados con campos eléctricos ha experimentado un creciente interés durante las dos últimas décadas debido, en gran medida, al desarrollo de nuevas técnicas para crear y estudiar átomos Rydberg en el laboratorio. Acompañando a estas nuevas técnicas experimentales, es necesario el desarrollo de modelos teóricos que nos permitan contrastar sus medidas y conocer mejor los fundamentos de los mismos. Desde el punto de vista teórico el conocimiento del desdoblamiento de los niveles energéticos de un átomo en función de la magnitud del campo eléctrico aplicado (lo que se conoce como mapa Stark) es el mejor punto de partida para la descripción del sistema y un prerrequisito fundamental para el cálculo de distintas propiedades atómicas en presencia del campo eléctrico tales como intensidades de transición, umbrales de ionización de campo eléctrico, tiempos de vida, posición y anchura de cruces evitados, etc. En este trabajo presentamos la adaptación del método de orbitales de defecto cuántico [1,2,3] al tratamiento del efecto Stark (SQDO) [4] y su aplicación al cálculo de los desdoblamientos energéticos y fuerzas de oscilador de estados Rydberg en los átomos de Li, Na y K. El propósito de este estudio es, por un lado, desarrollar métodos fiables para la determinación de propiedades atómicas en presencia de campos eléctricos y, por otro, mostrar la fiabilidad de las funciones de onda QDO en la descripción del efecto Stark en sistemas atómicos.

  16. En busca de un mejor proceso de detección del cáncer

    Cancer.gov

    El proyecto PROSPR, una investigación auspiciada por el NCI, busca examinar las fallas en el proceso de detección del cáncer y lograr mejoras en la forma en que se realizan los exámenes de detección del cáncer en la comunidad.

  17. Saluto del rappresentante degli studenti Andrea Vezzali Senato Accademico

    E-print Network

    Robbiano, Lorenzo

    ; essa è la rocca che domina o alimenta il mondo tutto del lavoro". Da questa suggestiva frase, tratta da, soprattutto, "domina o alimenta il mondo tutto del lavoro"? Dopo vent'anni di riforme che si sono riempite la

  18. Student Competition: Siting Potential Dams at Camp Del Webb, Utah

    E-print Network

    Wamser, William Kyle

    2007-11-14

    Siting Potential Dams at Camp Del Webb, Utah Presented By: Kyle Wamser Problem ? Camp Del Webb is Lacking an Onsite Lake ? High Adventure Bases generally need aquatics ? Large lake nearby, but transportation is required ? Possible Solution ? Create a...

  19. Programas e iniciativas de estudios clínicos del NCI

    Cancer.gov

    Información sobre los programas e iniciativas del NCI que patrocinan, realizan, crean o apoyan estudios clínicos, entre los que se incluyen la Red Nacional de Estudios Clínicos (NCTN) y el Programa de Investigación Oncológica Comunitaria (NCORP) del NCI.

  20. CareerService Il mondo del lavoro incontra studenti

    E-print Network

    in merito a: employer branding, campus recruiting, organizzazione di eventi, normativa del lavoro nostra offerta CONSULENZA BRANDING Analisi dei bisogni Studenti Laureati Target di Comunicazione del brand Obiettivi Eventi in Università Pianificazione Annunci di lavoro Lasciamo la parola alle aziende

  1. La reconstrucción del seno después de una mastectomía

    Cancer.gov

    Hoja informativa que describe la reconstrucción del seno (mama) después de una mastectomía. Contiene información sobre las opciones quirúrgicas, los cuidados de seguimiento y los exámenes de detección del cáncer de seno después de la reconstrucción.

  2. Approches actuelles au traitement du zona

    PubMed Central

    Bissonnette, R.; Leclerc, G.

    1992-01-01

    Herpes zoster is a very common pathology. A description of its clinical presentation and treatment in both immunocompromised and immunocompetent patients is provided. There is also a discussion of controversial aspects of treatment in the light of recent medical findings. ImagesFigure 1 PMID:21221384

  3. Elec 331 -Nervous System Del Operator

    E-print Network

    Pulfrey, David L.

    Elec 331 - Nervous System 1 Review , , , , , , , , , , , , Del Operator Gradient (result = vector y z F F F F F F y z y z z x x y F F F Nervous System · Central Nervous System ­ Brain ­ Spinal Chord · Peripheral Nervous System ­ "Conductive" network between CNS

  4. DEL MORAL, SANDLER & MUERDTER--1 draft version

    E-print Network

    del Moral, Roger

    on the Muddy River Lahar, Mount St. Helens, Washington R. del Moral Jeremy E. Sandler Claire P. Muerdter Abstract We surveyed vegetation 28 summers after the 1980 eruption of Mount St. Helens, Washington spawned intervals = 20 ft (6.09 m). Study conducted between 900 and 1320 m a.s.l. Introduction Mount St. Helens

  5. UNIVERSIDAD SIMON BOLIVAR SEDE DEL LITORAL

    E-print Network

    Vásquez, Carlos

    UNIVERSIDAD SIMON BOLIVAR SEDE DEL LITORAL ESPECIALIZACIÓN EN TELECOMUNICACIONES DECANATO DE POSTGRADO DENOMINACIÓN: CÓDIGO: ASIGNATURA: REDES DE DATOS (Capas 4, 5, 6 y 7) TI-7323 REQUISITOS: REDES DE.- OBJETIVO TERMINAL: Al finalizar la asignatura Redes de Datos (Capas 4, 5, 6 y 7), el estudiante deberá

  6. UNIVERSIDAD SIMON BOLIVAR SEDE DEL LITORAL

    E-print Network

    Vásquez, Carlos

    UNIVERSIDAD SIMON BOLIVAR SEDE DEL LITORAL ESPECIALIZACIÓN EN TELECOMUNICACIONES DECANATO DE POSTGRADO DENOMINACIÓN: CÓDIGO: ASIGNATURA: REDES DE DATOS (Capas 1, 2 y 3) TI-7312 REQUISITOS: TRANSMISIÓN: Al finalizar la asignatura Redes de Datos (Capas 1, 2 y 3), el estudiante deberá manejar los

  7. akihiro kanamori L'ipotesi del continuo*

    E-print Network

    Kanamori, Akihiro

    precisamente in che modo i numeri reali rappresentino punti del continuo lineare. Dovremo poi sviluppare un numeri reali andranno enumerati in modo da rispettare questo concetto di cardinalità. Georg Cantor compì trovata a una svolta, è emerso il problema di quali insiemi, specialmente insiemi di numeri reali, debbano

  8. DIRECCIN DEL PROYECTO Margarita San Andrs Moya

    E-print Network

    #12;DIRECCI�N DEL PROYECTO Margarita San Andrés Moya EDITA Universidad Complutense de Madrid-84-96701-69-4 Depósito Legal: M-18419-2015 © Universidad Complutense de Madrid © De las imágenes: los autores Todos los

  9. PASO DEL NORTE SUMMER OZONE STUDY

    EPA Science Inventory

    The Paso del Norte Summer Ozone Study was designed to evaluate potential control strategies for their efficacy in reducing ozone and carbon monoxide concentrations in the El Paso-Ciudad Juarez-Sunland Park international airshed of Texas, New Mexico, and Chihuahua. A field study ...

  10. Hospital del Mar Medical Research Institute Barcelona 2013

    E-print Network

    IMIM Hospital del Mar Medical Research Institute Barcelona 2013 #12;© Hospital del Mar Medical Research Institute (IMIM) Hospital del Mar Medical Research Institute (IMIM) Dr. Aiguader, 88 08003: hores.com Graphic design: Lluïsa Cobos Photographies of the research groups: Raúl Peña Photographies

  11. DERECHOS DEL EMPLEADO LEy PARA LA PROtECCin

    E-print Network

    Rock, Chris

    DERECHOS DEL EMPLEADO LEy PARA LA PROtECCión DEL EMPLEADO COntRA LA PRuEbA DEL POLígRAfO PROHIBICIONES ExENCIONES DERECHOS DE LOS ExAMINADOS CUMPLIMIENTO Generalmente se le prohíbe al empleador que le aspirante a un trabajo por haberse negado a someterse a la prueba o por haberse acogido a otros derechos

  12. On the Approximations of Multiple target filtering P. Del Moral

    E-print Network

    Del Moral , Pierre

    On the Approximations of Multiple target filtering equations P. Del Moral Centre INRIA Bordeaux (2010). To appear in Stochastic Analysis and Applications (2011). Del Moral (INRIA) INRIA Centre models 7 Approximation models Del Moral (INRIA) INRIA Centre Bordeaux-Sud Ouest, France 2 / 25 #12;Some

  13. Particle simulation of rare events P. Del Moral

    E-print Network

    Vallette, Bruno

    Particle simulation of rare events P. Del Moral Centre INRIA de Bordeaux - Sud Ouest Recent Advancements in the Theory and Practice of Credit Derivatives, Nice Sept. 2009 P. Del Moral (INRIA) INRIA-Kac models 3 Normalizing constant estimation 4 Some references P. Del Moral (INRIA) INRIA Bordeaux-Sud Ouest

  14. On the Approximations of Multiple target filtering P. Del Moral

    E-print Network

    Del Moral , Pierre

    On the Approximations of Multiple target filtering equations P. Del Moral Centre INRIA de Bordeaux (2010). To appear in Stochastic Analysis and Applications (2011). P. Del Moral (INRIA) INRIA Bordeaux Approximation models P. Del Moral (INRIA) INRIA Bordeaux-Sud Ouest 2 / 25 #12;Some notation : E measurable space

  15. Hoja informativa sobre la calidad del aire interior

    E-print Network

    Hoja informativa sobre la calidad del aire interior La mala calidad del aire interior proviene de de uso doméstico como limpiadores y pesticidas Cómo mejorar la calidad del aire interior · Abra las. · Arregle las fugas de agua para evitar el moho. · Use spray contra insectos solo cuando sea absolutamente

  16. julio-septiembre2006Cinvestav74 Resea del libro

    E-print Network

    julio-septiembre2006·Cinvestav74 Reseña del libro Ejemplos prácticos del uso de la resonancia Departamento de Química en 1993, conocería personalmente a todos los autores del libro. En algunas ocasiones comenté con ellos la dificultad de encontrar libros de texto en los que se abordaran ejemplos reales

  17. RIO GRANDE FLOODWAY SAN ACACIA TO BOSQUE DEL APACHE UNIT

    E-print Network

    US Army Corps of Engineers

    #12;RIO GRANDE FLOODWAY SAN ACACIA TO BOSQUE DEL APACHE UNIT SOCORRO COUNTY, NEW MEXICO GENERAL the IEPR for the Rio Grande Floodway, San Acacia to Bosque del Apache Unit, draft General Reevaluation to Independent Rio Grande Floodway, San Acacia External Peer Review to Bosque del Apache Unit. · Low = Affects

  18. Cursos Avanzados Eduardo Torroja 2015 Objetivo del curso

    E-print Network

    Cursos Avanzados Eduardo Torroja 2015 Objetivo del curso El objetivo de los presentes Cursos la innovación. A quien va dirigido El curso está dirigido a estudiantes universitarios y instituciones implicadas hacen de este curso un referente técnico internacional. Título del curso Resumen del

  19. Especialista El programa del curso Especialista en Gestin Clnica, ofrece

    E-print Network

    Escolano, Francisco

    Especialista en Gestión Clínica El programa del curso Especialista en Gestión Clínica, ofrece alInformación Titulo: Curso de posgrado : Especialista en Gestión clínica. Duración: 1 curso académico. 2 semestres: del 1 al 31 de Julio de 2015. Matrícula: Septiembre 2015. Precio del curso: 1,890 euros (distribuidos

  20. 33 CFR 80.1118 - Marina Del Rey, CA.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 2010-07-01 2010-07-01 false Marina Del Rey, CA. 80.1118 Section 80...DEMARCATION LINES Pacific Coast § 80.1118 Marina Del Rey, CA. (a) A line drawn from Marina Del Rey Breakwater South Light 1 to...

  1. 33 CFR 80.1118 - Marina Del Rey, CA.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 2011-07-01 2011-07-01 false Marina Del Rey, CA. 80.1118 Section 80...DEMARCATION LINES Pacific Coast § 80.1118 Marina Del Rey, CA. (a) A line drawn from Marina Del Rey Breakwater South Light 1 to...

  2. Vigilando la Calidad del Agua de los Grandes Rios de la Nacion: El Programa NASQAN del Rio Grande (Rio Bravo del Norte)

    USGS Publications Warehouse

    Lurry, Dee L.; Reutter, David C.; Wells, Frank C.; Rivera, M.C., (translator); Munoz, A.

    1998-01-01

    La Oficina del Estudio Geologico de los Estados Unidos (U.S. Geological Survey, 0 USGS) ha monitoreado la calidad del agua de la cuenca del Rio Grande (Rio Bravo del Norte) desde 1995 como parte de la rediseiiada Red Nacional para Contabilizar la Calidad del Agua de los Rios (National Stream Quality Accounting Network, o NASOAN) (Hooper and others, 1997). EI programa NASOAN fue diseiiado para caracterizar las concentraciones y el transporte de sedimento y constituyentes quimicos seleccionados, encontrados en los grandes rios de los Estados Unidos - incluyendo el Misisipi, el Colorado y el Columbia, ademas del Rio Grande. En estas cuatro cuencas, el USGS opera actualmente (1998) una red de 40 puntos de muestreo pertenecientes a NASOAN, con un enfasis en cuantificar el flujo en masa (la cantidad de material que pasa por la estacion, expresado en toneladas por dial para cada constituyente. Aplicacando un enfoque consistente, basado en la cuantificacion de flujos en la cuenca del Rio Grande, el programa NASOAN esta generando la informacion necesaria para identificar fuentes regionales de diversos contaminantes, incluyendo sustancias qui micas agricolas y trazas elementos en la cuenca. EI efecto de las grandes reservas en el Rio Grande se puede observar segun los flujos de constituyentes discurren a 10 largo del rio. EI analisis de los flujos de constituyentes a escala de la cuenca proveera los medios para evaluar la influencia de la actividad humana sobre las condiciones de calidad del agua del Rio Grande.

  3. Comportamiento del Helio en estrellas químicamente peculiares

    NASA Astrophysics Data System (ADS)

    Malaroda, S. M.; López García, Z.; Leone, F.; Catalano, F.

    Las estrellas químicamente peculiares (CP) se caracterizan por tener deficiencias y sobreabundancias de algunos elementos químicos de hasta 106 veces la abundancia solar. Además presentan variaciones en las líneas espectrales. Se piensa que ello se debe a que los campos magnéticos presentes en este tipo de estrellas son principalmente dipolares, con un eje de simetría diferente del eje de rotación. La distribución de los elementos sobreabundantes y deficientes no es homogénea sobre la superficie estelar y las variaciones observadas serían una consecuencia directa de la rotación estelar. Entre los elementos con abundancia anómala se encuentra el Helio, cuyas líneas tienen intensidades que no son consistentes con una abundancia normal, que no puede ser determinada del modo usual, o sea, considerando una atmósfera con composición solar. Con el fin de determinar la abundancia de este elemento, se inició un estudio de estrellas anómalas de Helio, Hew y He strong. Además se determinarán las abundancias de otros elementos anómalos como ser el Si, Cr, Mg, Mn y Fe. Las mismas se determinan del modo tradicional, o sea: a) medida de los anchos equivalentes de las líneas de los distintos elementos analizados; b) adopción de la temperatura efectiva, gravedad y abundancia del Helio; c) cálculo del modelo de atmósfera d) comparación con las observaciones y reinicio de un proceso iterativo hasta lograr un acuerdo entre todos los parámetros analizados. Las observaciones se llevaron a cabo en el Complejo Astronómico El Leoncito. Se observaron setenta y ocho estrellas anómalas de Helio. En este momento se está procediendo a calcular las abundancias correspondientes a los distintos elementos químicos. Para ello se hace uso de los modelos de Kurucz, ATLAS9. Los cálculos NLTE de las líneas de Helio se llevan a cabo con el programa MULTI y se compararán con los realizados con el programa WIDTH9 de Kurucz (LTE), con el objeto de resaltar la importancia de los efectos NLTE.

  4. Talleres del primer cuatrimestre. Curso 2015-2016 CINE EN VERSIN ORIGINAL EN LA UA

    E-print Network

    Escolano, Francisco

    Talleres del primer cuatrimestre. Curso 2015-2016 1 CINE EN VERSIÓN ORIGINAL EN LA UA Coordinador Scorsese, 1986) #12;Talleres del primer cuatrimestre. Curso 2015-2016 2 Todas la proyecciones en versión OBTENCIÓN DEL CERTIFICADO ES IMPRESCINDIBLE: *UNA ASISTENCIA MÍNIMA DEL 80% DEL TOTAL DE HORAS DEL CURSO

  5. Clinical and laboratory update on the DEL variant.

    PubMed

    Nuchnoi, Pornlada; Thongbus, Jairak; Srisarin, Apapan; Kerdpin, Usanee; Prachayasittikul, Virapong

    2014-01-01

    Serological assays for the RhD blood group are based on detection of the RhD antigen on human red blood cells using a specific anti-D antibody. The weak expression of the RhD antigen in the DEL variant hinders the sensitivity of conventional serological assays. Evidence of anti-D immunization in patients with D-negativity who have received DEL-variant blood units has been reported in various populations. This observation has prompted the need for genetic epidemiological and clinical data on the DEL variant in the development of DEL molecular diagnostic testing. This review highlights the molecular features of the DEL variant, the clinical consequences of DEL-blood transfusion, and current approaches for detection of the DEL-variant for donor screening and transfusion. PMID:25316658

  6. Hacia una bibliografía del teatro venezolano colonial.

    E-print Network

    Greymont, Sally J.

    1975-04-01

    hispanoamericana: 1. La colonia, Cien años de república. 5a ed. Brevarios, No. 89. México: Fondo de Cultura Económica, 1965. 473 págs. 46 LATIN AMERICAN THEATRE REVIEW Antolínez, Gilberto. "El teatro institución de los Muku y Jirajara," Revista Nacional de...: Universidad Central de Venezuela (nov 1966), 1-4. . "Teatro," en Cuaderno. Dirección de Cultura, Centro de Investigación y Desarrollo del Teatro, No. 2. Caracas: Universidad Central de Venezuela (nov 1966), 5-9. . "Venezuela consolada," en Poesías. Obras...

  7. Panorama del teatro guatemalteco de los noventa

    E-print Network

    Mé ndez de Penedo, Lucrecia

    2000-10-01

    , pues aunque está ambientada en el lejano oeste, y con incorporación de cantos, danzas y música, su estructura requiere la alusión al proceso electoral que esté en curso. Se presentó a inicios de la década del noventa bajo la dirección de Salomón... Ovidio Gálvez, y la ya mencionada Rayuela. En el Teatro Abril se impartieron algunos cursos de teatro. En Antigua Guatemala subsiste la Academia de Arte Dramático Antigüeño de la familia Gaitán y la nueva El Sitio Players de Enrique Matheu y...

  8. Qumica del Cemento El objetivo del curso es introducir a los alumnos en la qumica de los cementos. Se aborda, desde puntos de vista cientficos

    E-print Network

    Química del Cemento El objetivo del curso es introducir a los alumnos en la química de los cementos usados en el hormigón). El curso se completa con prácticas y la visita a una fábrica de cemento. Título del curso Resumen del contenido y objeto del curso Áreas de interés del curso Ciencia y tecnología de

  9. Estudio teórico del CO2. Orbitales de valencia y del ``core''

    NASA Astrophysics Data System (ADS)

    Olalla Gutiérrez, E.

    Hemos calculado las intensidades de las transiciones E1 a los miembros de las series de Rydberg con origen en los orbitales ``no enlazantes'' del dióxido de carbono, especie de conocida relevancia atmosférica. Se han computado, asimismo, los continuos de fotoionización correspondientes a los distintos canales de ionización, representándolos como densidad espectral de fuerza de oscilador frente a la energía del fotón incidente; mostramos los resultados df/dE para la fotoionización total de esta especie en el intervalo 15-60 eV. Todos los cálculos se han llevado a cabo mediante la formulación Molecular del Método de los Orbitales de Defecto Cuántico, MQDO [1,2]. La calidad de los resultados que presentamos se ha evaluado en base a la comparación con los datos, tanto experimentales como teóricos, disponibles en la bibliografía. El acuerdo encontrado es altamente satisfactorio

  10. Morphology, geology and geochemistry of the "Salar del Gran Bajo del Gualicho" (Rio Negro, Argentina)

    USGS Publications Warehouse

    Angelucci, A.; Barbieri, M.; Brodtkorb, A.; Ciccacci, S.; Civitelli, G.; De Barrio, R.; Di, Filippo M.; Fredi, P.; Friedman, I.; Lombardi, S.; Schalamuk, A.I.; Toro, B.

    1996-01-01

    A multidisciplinary study of the Gran Bajo del Gualicho area (Rio Negro - Argentina) was carried out; the aim was to delineate its geological and geomorphological evolution and to estabilish the genesis of salts filling the depression. Climatic conditions were analized first to individuate their role in the present morphogenetic processes; moreover the main morphological features of present landscape were examined as well as the stratigraphy of the outcropping formations, and of the Gran Bajo del Gualicho Formation in particular. Finally, a possible geomorphological evolution of the studied area was traced. Geophysical analyses allowed to estabilish that the paleosurface shaped on the crystalline basement is strongly uneven and shows evidence of the strong tectonic phases it underwent. The result of isotope analyses confirmed that the salt deposits on the Gran Bajo del Gualicho bottom were produced by fresh water evaporation, while strontium isotope ratio suggested that such waters were responsible for solubilization of more ancient evaporitic deposits.

  11. Del-1 overexpression potentiates lung cancer cell proliferation and invasion.

    PubMed

    Lee, Seung-Hwan; Kim, Dong-Young; Jing, Feifeng; Kim, Hyesoon; Yun, Chae-Ok; Han, Deok-Jong; Choi, Eun Young

    2015-12-01

    Developmental endothelial locus-1 (Del-1) is an endogenous anti-inflammatory molecule that is highly expressed in the lung and the brain and limits leukocyte migration to these tissues. We previously reported that the expression of Del-1 is positively regulated by p53 in lung endothelial cells. Although several reports have implicated the altered expression of Del-1 gene in cancer patients, little is known about its role in tumor cells. We here investigated the effect of Del-1 on the features of human lung carcinoma cells. Del-1 mRNA was found to be significantly decreased in the human lung adenocarcinoma cell lines A549 (containing wild type of p53), H1299 (null for p53) and EKVX (mutant p53), compared to in human normal lung epithelial BEAS-2B cells and MRC-5 fibroblasts. The decrease of Del-1 expression was dependent on the p53 activity in the cell lines, but not on the expression of p53. Neither treatment with recombinant human Del-1 protein nor the introduction of adenovirus expressing Del-1 altered the expression of the apoptosis regulators BAX, PUMA and Bcl-2. Unexpectedly, the adenovirus-mediated overexpression of Del-1 gene into the lung carcinoma cell lines promoted proliferation and invasion of the lung carcinoma cells, as revealed by BrdU incorporation and transwell invasion assays, respectively. In addition, overexpression of the Del-1 gene enhanced features of epithelial-mesenchymal transition (EMT), such as increasing vimentin while decreasing E-cadherin in A549 cells, and increases in the level of Slug, an EMT-associated transcription regulator. Our findings demonstrated for the first time that there are deleterious effects of high levels of Del-1 in lung carcinoma cells, and suggest that Del-1 may be used as a diagnostic or prognostic marker for cancer progression, and as a novel therapeutic target for lung carcinoma. PMID:26545781

  12. Festival Report: II Taller Centroamericano y del Caribe: Guatemala

    E-print Network

    Bravo-Elizondo, Pedro

    1991-10-01

    Taller Centroamericano y del Caribe: Guatemala Pedro Bravo-Elízondo En el mes de agosto de 1990, durante la primera asamblea general de la Coordinadora Centroamericana y del Caribe de Teatro, realizada en Tegucigalpa, Honduras, se acordó que el II... Taller se realizara en la ciudad de Guatemala, durante el mes de agosto de 1991. En el Centro Cultural de Guatemala, Miguel Ángel Asturias, se realizó la inauguración el domingo 4 de agosto, con la presentación del Ballet Folklórico y su Marimba, y...

  13. The Mexican Naturalist Revista oficial del Curso de Campo

    E-print Network

    Arroyo Rodríguez, Víctor

    , Pernambuco, Brasil §Centro de Investigaciones en Ecosistemas, Universidad Nacional Autónoma de México, incrementando la homogenización florística dentro del ecosistema (menor diversidad beta). Probamos es

  14. Efecto del Programa de Entrenamiento “Manejo del Dolor” en la Documentación de Enfermería en el Expediente Electrónico

    PubMed Central

    Monsiváis, María Guadalupe Moreno; Guzmán, Ma. Guadalupe Interial; Flores, Paz Francisco Sauceda; Arreola, Leticia Vázquez

    2012-01-01

    Resumen En el presente trabajo se muestra la importancia de entrenar al personal de enfermería para mejorar la documentación en el expediente electrónico. Se eligió el manejo del dolor por ser un área prioritaria; una alta proporción de pacientes en período post operatorio cursa con dolor, por lo tanto, la documentación debe ser útil para la toma de decisiones clínicas. Se implementó un programa de entrenamiento denominado “Manejo del Dolor” dirigido al personal de enfermería. Se utilizó la tecnología de la información como herramienta para fortalecer el conocimiento con base en la revisión sistemática de la literatura; el personal de enfermería participante seleccionó la mejor evidencia; posteriormente se trabajó en la transferencia de este conocimiento a la práctica a través del diseño de un protocolo para el manejo del dolor. Se concluye que el conocimiento del manejo del dolor es fundamental para que enfermería documente con mayor precisión sus intervenciones. PMID:24199106

  15. Manual del espectrógrafo multifunción de Bosque Alegre

    NASA Astrophysics Data System (ADS)

    Díaz, R.; Paolantonio, S.; Carranza, G.; Goldes, G.

    Este manual consta de 120 páginas y resume las características del Espectrógrafo Multifunción instalado en el telescopio de 1.54 m de la Estación Astrofísica de Bosque Alegre. En este trabajo se describen, además, las técnicas a emplear para su puesta a punto y la secuencia de operaciones para la obtención de datos en cada uno de los modos que ya se encuentran en funcionamiento. Parte de este trabajo se realizó con el apoyo de la Asociación Argentina de Astronomía, a través de becas otorgadas a R.D. y S.P..

  16. RELACIÓN MÉDICO PACIENTE: DERECHOS DEL ADULTO MAYOR

    PubMed Central

    Barrantes-Monge, Melba; Rodríguez, Eduardo; Lama, Alexis

    2009-01-01

    Existen prejuicios en relación con la vejez, incluso entre los profesionales que se dedican a la gerontología. Uno común y peligroso es considerar que los viejos son todos enfermos o discapacitados. La relación médico-paciente es la piedra angular de la práctica y ética médicas. Para alcanzar el respeto por los adultos mayores es necesaria una medicina prudente, basada en una práctica en la cual la reflexión ética y clínica pueda contribuir. Esto último es posible si se hacen valer los derechos del adulto mayor, en particular como paciente para la toma de decisiones. PMID:20379380

  17. Reapertura del Teatro del Pueblo:´Unir la belleza con la resistencia´

    E-print Network

    Castillo, Marí a

    1996-10-01

    . Venimos a concretar un proyecto con el que soñamos: un centro de cultura al servicio de la sociedad." Más representativas aún son las palabras de Roberto Cossa quien se hace portavoz de los emprendedores de esta nueva empresa: "Los protagonistas del...

  18. CONVOCATORIA A LOS ESTUDIANTES DEL CENTRO DE INVESTIGACIN Y DE ESTUDIOS AVANZADOS DEL INSTITUTO

    E-print Network

    POLITÉCNICO NACIONAL PARA LA PRESENTACIÓN DE PROYECTOS DE EMPRENDIMIENTO emprendedores Antecedentes El Centro, a través de la cual se convoca al concurso IDi4Biz®- emprendedores. En este contexto, el Cinvestav ha el marco del concurso IDi4Biz®-emprendedores. Con esta iniciativa, el Cinvestav busca aprovechar

  19. Huave de San Mateo del Mar, Oaxaca (Huave of San Mateo del Mar, Oaxaca).

    ERIC Educational Resources Information Center

    Mexico Coll. (Mexico City)

    This document is one of 17 volumes on indigenous Mexican languages and is the result of a project undertaken by the Archivo de Lenguas Indigenas de Mexico. This volume contains information on Huave, an indigenous language of Mexico spoken in San Mateo del Mar, in the state of Oaxaca. The objective of collecting such a representative sampling of…

  20. Respuestas a las preguntas del ejercicio de ``La Expansi'on del Universo y la Ley de Hubble''

    E-print Network

    Rodriguez, Luis F.

    Respuestas a las preguntas del ejercicio de ``La Expansi'on del Universo y la Ley de Hubble'' --La constante de Hubble, H, debe de salir alrededor de 70 km s \\Gamma1 Mpc \\Gamma1 . El tiempo transcurrido desde el inicio del Universo ser'a t = D=V . Pero por otra parte, la constante de Hubble es H = V=D, de

  1. Instantánea de los cánceres de cerebro y del sistema nervioso central

    Cancer.gov

    Información sobre las tendencias de incidencia, mortalidad y financiamiento del NCI sobre los cánceres de cerebro y del sistema nervioso central; así como ejemplos de actividades del NCI y adelantos en la investigación de estos tipos de cáncer.

  2. Los Derechos de los Pacientes del Centro Clnico

    E-print Network

    Los Derechos de los Pacientes del Centro Clínico Los Derechos de los Pacientes del Centro Clínico medir las respuestas de los pacientes al tratamiento. Existen procesos que protegen los derechos de paciente que se observen los derechos fundamentales de la dignidad humana. Esta Declaración de Derechos

  3. Primer censo nacional del jaguar Cuauhtmoc Chvez, Gerardo Ceballos,

    E-print Network

    Nacional Autónoma de México, Universidad

    133 Primer censo nacional del jaguar Cuauhtémoc Chávez, Gerardo Ceballos, Rodrigo Medellín A. y, como los jaguares,deben de planearse a diferentes escalas (local a geográfica),además de tomar en interacciones con las actividades humanas. El Censo Nacional del Jaguar y sus Presas (CENJAGUAR), pretende

  4. Se evitaron casi 800 000 muertes por descenso del tabaquismo

    Cancer.gov

    Programas y estrategias de control del tabaco del siglo XX fueron responsables de la prevención de más de 795 000 muertes por cáncer de pulmón en Estados Unidos de 1975 al 2000. Si todo el tabaquismo en este país hubiera cesado después de la publicación d

  5. Page 1 of 8 Universidad De Carolina Del Este

    E-print Network

    Gopalakrishnan, K.

    Abril del 2003 REVISADO: 13 de Octubre del 2014 En ECU Physicians (por sus siglas en ingles ECUP) y. Este Aviso se aplica a toda su información médica protegida ( PHI por sus siglas en ingles) que REVELAR SU INFORMACION MEDICA PROTEGIDA (PHI POR SUS SIGLAS EN INGLES ) SIN SU AUTORIZACION EN LOS

  6. Pastoral del Nino: Bringing the Abundant Life to Paraguayan Children

    ERIC Educational Resources Information Center

    Austin, Ann Berghout; Aquino, Cyle; Burro, Elizabeth

    2007-01-01

    Pastoral del Nino is transforming children's lives in rural Paraguay. Part of Pastoral Social (Catholic Social Services), Pastoral del Nino's primary focus is to bring "vida en abundancia" (the abundant life) to families by ensuring that mothers survive childbirth and children reach their first birthdays. In addition, the organization promotes…

  7. Una possibile estensione del sistema "balanced scorecard" Pier Franco Camussone

    E-print Network

    Una possibile estensione del sistema "balanced scorecard" Pier Franco Camussone 1 Dipartimento, I-38100, Trento paolo.giorgini@dit.unitn.it Sommario. Il sistema delle Balanced Scorecard, proposto estensione del sistema delle Balanced Scorecard che prevede un più raffinato insieme di relazioni tra

  8. 33 CFR 110.111 - Marina del Rey Harbor, Calif.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ...Navigable Waters 1 2011-07-01 2011-07-01 false Marina del Rey Harbor, Calif. 110.111 Section 110.111 ...ANCHORAGE REGULATIONS Special Anchorage Areas § 110.111 Marina del Rey Harbor, Calif. An area in the main channel...

  9. 33 CFR 110.111 - Marina del Rey Harbor, Calif.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...Navigable Waters 1 2010-07-01 2010-07-01 false Marina del Rey Harbor, Calif. 110.111 Section 110.111 ...ANCHORAGE REGULATIONS Special Anchorage Areas § 110.111 Marina del Rey Harbor, Calif. An area in the main channel...

  10. ON THE MOTIVE OF A QUOTIENT VARIETY SEBASTIAN DEL BA ~

    E-print Network

    Politècnica de Catalunya, Universitat

    ON THE MOTIVE OF A QUOTIENT VARIETY SEBASTIAN DEL BA ~ NO ROLLIN AND VICENTE NAVARRO AZNAR En with the realization functors and Chow groups. Recently, in the case char k = 0, Guill'en and Navarro Aznar have given. DEL BA ~ NO ROLLIN AND V. NAVARRO AZNAR group, K 0 M k , these decompositions were considered by Denef

  11. NOM / NOMBRE Certificat d'Aptitud Pedaggica (CAP) del curs/Certificado de Aptitud Pedaggica (CAP) del curso

    E-print Network

    Escolano, Francisco

    Pedagógica (CAP) del curso Tots els cursos / Todos los cursos Dels cursos relacionats a continuació / de los cursos relacionados a continuación DENOMINACIÓ / DENOMINACIÓN DATA / FECHA Vaig rebre el certificat DE CERTIFICADOS Cursos de Formació Contínua relacionats a continuació /cursos de Formación Continua

  12. Installazione "Certification Autority" del Dipartimento di Fisica. Installare la "Certification Autority" del Dipartimento di Fisica necessario per

    E-print Network

    Roma "La Sapienza", Università di

    Installazione "Certification Autority" del Dipartimento di Fisica. Installare la "Certification Autority" del Dipartimento di Fisica è necessario per evitare i messaggi di avviso che si ricevono quando si visitano pagine HTML che utilizzano una connessione crittografata (SSL). L'utilizzo di una tale

  13. Más allá del “formato memoria”: la repostulación del imaginario postdictatorial en Los rubios de Albertina Carri

    E-print Network

    Garibotto, Veró nica; Gó mez, Antonio

    2006-01-01

    mecanismos constructivos del film también se constituye en un modo de desrealizar la empresa documental por una doble vía: la objetivación de las muchas instancias de interferencia entre lo real y su representación, y la abierta apelación a herramientas de... constructivos. Algo similar sucede con su estatus temporal: se acentúa en varias ocasiones el valor de la preproducción: varias de las entrevistas son segundos contactos con los entrevistados y el primero no aparece en el corte final. Así, estos testimonios...

  14. [La Medicina del Lavoro: 100 volumes].

    PubMed

    Zocchetti, C

    2009-01-01

    With these pages La Medicina del Lavoro starts its 100th volume, so we have yet another historical occasion to celebrate the oldest occupational health journal in the world that is still publishing. Over the last few years we have had many occasions to celebrate, for example several anniversaries of the Journal (the 80th volume in 1989, 90 years in 1992, 100 years in 2001); the centenary of the foundation of the Clinica del Lavoro "Luigi Devoto" of Milan in 2001; the celebration of the 300 years' anniversary of the publication of De Morbis Artificum Diatriba by Bernardino Ramazzini, and we obviously hope to continue for many years to come in this positive outlook. One hundred volumes makes for a very large collection, with the highs and lows ofthe Journal's history (here we mean the variations in number of pages and physical size of the Journal). It is thanks to the Editors-in-chief(there have been very few so we can cite them all: Luigi Devoto, 1901-1936; Luigi Preti, 1936-1941; Enrico Vigliani, 1943-1992; e Vito Foà, 1992 to the present); the contributors who in various ways and with varying degrees of commitment but always with an exceptional personal participation, that it has been possible to reach 100 volumes, starting with C. Moreschi who, along with Luigi Devoto, was the first and sole editor at the Journal's foundation; up to the present extended and impressive editorial board; the printers (from the first. Tipografia Cooperativa, Via dei Molini in Pavia, to the latest: Casa Editrice Mattioli in Fidenza); the sponsors, including the most evident who, via advertising (rather limited as a matter offact), directly gave information about themselves, but also those who have often been or are behind the scenes, ensuring fundamental support which is not visible; content. articles, news, events, reports, ideas, opinions, photographs, tables, numbers... etc, which are really impossible to sum up. But the true collection which, for obvious reasons, cannot be individually named, consists of the people and the ideas that have enriched the history of the Journal in its over 100 years of existence. And the subscribers, above all, who by their almost anonymous presence have been the true guarantors of the Journal's ife. And of course the contributors who with their articles have consigned a part of their lives to history. Starting from 1925 we counted nearly 11.000, a really grand number. It would be wonderful if we could invite them all to a hypothetical (and impossible) grand convention to simply say "Thank you, your contributions will not be forgotten". There have been 100 volumes but in actual fact the Journal is more than 100 years old. It was founded in Pavia in 1901 as Il Lavoro-Rivista di fisiologia, clinica ed igiene del lavoro, and between 1901 and 1910 only three volumes were published, then, due to the difficulties during the First World War and the immediate post-war years, there were no issues in 1916, 1918 and 1919. Issues finally became regular in 1920 with volume 11; from that moment on not one issue was missed and the Journal even got through the Second World War without interruptions. In 1925, with volume 16, it took on the name that still distinguishes it to-day: La Medicina del Lavoro, "the official standard bearer of a work of enormous scientific, social and political content" as Luigi Devoto presented the event at the time. The first few years of the Journal were difficult ones (with only three volumes published in 10 years) to the effect that events such as the First International Congress on Occupational Diseases (Milano, 1906), the foundation of the International Commission for Occupational Health (1906), the First National Italian Congress on Occupational Diseases (Palermo, 1907), and above all the inauguration of the Clinica del Lavoro in Milano (20 March, 1910) are not reported in the Journal, which by 1911 had resumed publication but had moved to Milan. Many years have passed since those first three volumes and in the meantime we have moved on to another century and

  15. Comunicacionas mansualas dal Instituto Intllrnacional de la Potase, Berna (Suiza) Ciencia del Suelo

    E-print Network

    Sparks, Donald L.

    del Suelo 728 continuacion N° 5/1981 La quimica del potasio en suelos arenosos* (On the chemistry of potassium in sandy soils) D, L. Sparks Profesor Auxiliar de Qulmica Fisica del Suelo, Departamento de y nativo en suelos Dothan. Sparks D.L., Zelazny L. W., Martens D. C.: Cineticas del Intercambio de

  16. Coordinacin de la Especializacin en Ingeniera del Gas Natural Valle de Sartenejas, Universidad Simn Bolvar,

    E-print Network

    Vásquez, Carlos

    Coordinación de la Especialización en Ingeniería del Gas Natural Valle de Sartenejas, Universidad DEL GAS NATURAL Grado académico que otorga Especialista en Ingeniería del Gas Natural. Perfil de egresado El egresado de la Especialización del Gas Natural tendrá la competencia para: Manejar y aplicar

  17. PROVA DI CONOSCENZA DELLA LINGUA ITALIANA del 3 Settembre 2015

    E-print Network

    Di Pillo, Gianni

    , Fisiche e Naturali (sede all'interno della città universitaria) AULA "Rasetti" ­ Edificio Guglielmo Marconi (vecchio edificio) del Dipartimento di Fisica ORE 15,30 Argomenti: Il colloquio consisterà in una

  18. Modular cell biology: retroactivity and insulation Domitilla Del Vecchio1,

    E-print Network

    Sontag, Eduardo

    Modular cell biology: retroactivity and insulation Domitilla Del Vecchio1, *, Alexander J Ninfa2 a remarkable insulation property, due to the fast timescales of the phosphorylation and dephosphorylation: computational methods; metabolic and regulatory networks Keywords: feedback; insulation; modularity; singular

  19. Calidad del aire interior y salud en las viviendas

    E-print Network

    puede tomar las siguientes medidas para mejorar la calidad del aire interior: 1. Respire aire fresco t Abra las ventanas siempre que pueda para que entre el aire fresco t Intente permanecer el mayor tiempo

  20. La fiesta del mulato de Luisa Josefina Hernández

    E-print Network

    Nigro, Kirsten F.

    1980-07-01

    situaciones escénicas muy variadas, dentro de diversas estructuras teatrales.1 Como bien ha señalado John Knowles, el conjunto de esta obra constituye un microcosmos del desarrollo de las formas dramáticas en México a partir de los años cincuenta.2 Al...

  1. Particle approximation of multiple object filtering problems P. Del Moral

    E-print Network

    Del Moral , Pierre

    Particle association measures #12;Introduction/notation Defense Industrial Research project Some basic research project 1. Defense industrial Contract : ALEA INRIA & DCNS Toulon (2009) 2. National ResearchParticle approximation of multiple object filtering problems P. Del Moral UNSW, School

  2. Centro para la Salud Mundial (CGH) del NCI

    Cancer.gov

    El Centro para la Salud Mundial (CGH) del NCI coordina actividades de investigación y trabaja con socios nacionales e internacionales para comprender y enfrentar la carga que representa el cáncer a nivel mundial.

  3. Particle methods in stochastic engineering P. Del Moral

    E-print Network

    Del Moral , Pierre

    application model areas : particle filtering, robotics, image processing, audio signal, tracking, GPS, fluid and particle algorithms : convergence, performance analysis, fluctuations, large deviations, propagations field particle interpretations of nonlinear PDE and measure valued equations. P. Del Moral (INRIA

  4. Informe trata el descenso del cáncer y los tumores cerebrales

    Cancer.gov

    Los índices de mortalidad en los Estados Unidos de todos los cánceres en hombres y mujeres siguieron bajando entre 2003 y 2007, que es el período más reciente del que se disponen datos, según el último Informe Anual a la Nación sobre el Estado del Cáncer. El informe encuentra también que el índice general combinado de nuevos diagnósticos de cáncer en hombres y mujeres decreció un promedio un poco menos de 1% por año en el mismo período.

  5. Miami: Meca del exilio cubano y escenario medido aunque efervescente

    E-print Network

    Rizk, Beatriz J.

    2000-10-01

    esenciales de una identidad cultural" (2000); o por "transparentar mediante los personajes secundarios las coordenadas históricas y la relación entre el medio familiar y la sociedad..[que] conectan el microcosmos del taller con la amplitud del universo..., El extravío (1987-88) de Julio Matas y hasta a la singular parodia Las hetairas habaneras (una melotragedia cubana) (1977) de José Corrales y Manuel Pereira, escritas en el exilio. Ahora, si dentro de estas familias, microcosmos de la sociedad, los...

  6. Archivo de placas astrométricas del Observatorio de La Plata

    NASA Astrophysics Data System (ADS)

    di Sisto, R.; Orellana, R. B.

    Se ha realizado una base de datos con las placas fotográficas obtenidas con el Astrográfico del Observatorio de La Plata. Se han clasificado un total de 3000 placas obtenidas para asteroides y cometas. El acceso a la base de datos se hará por FTP y la misma contendrá la siguiente información: fecha y tiempo de exposición, coordenadas del centro de placa, tipo de emulsión fotográfica, estado de la placa, objeto fotografiado.

  7. 65. Photographer unknown March 1931 DEL NORTE COUNTY, SECTION B, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    65. Photographer unknown March 1931 DEL NORTE COUNTY, SECTION B, HIGHWAY 1, 1-DN-1-B #66A, STA. 166.0+00 WIDENED ROADBED BEFORE COVERING LOG CRIB, 3-31. BACK READS: WIDENING ROAD BED WITH LOGS, APPROX 30 SQUARE & 60 LONG ON DN-1 SEC B STA 156+. Stamped office copy, - Redwood National & State Parks Roads, California coast from Crescent City to Trinidad, Crescent City, Del Norte County, CA

  8. FRONTERAS EN CIENCIA DE MATERIALES Curso de postgrado del CSIC

    E-print Network

    FRONTERAS EN CIENCIA DE MATERIALES Curso de postgrado del CSIC 29 marzo -15 abril 2016 Curso de introducción a la investigación en las fronteras del conocimiento en ciencia de materiales. El curso está computación cuántica, entre otros. La realización de este curso se reconoce para la obtención de créditos

  9. FRONTERAS EN CIENCIA DE MATERIALES Curso de postgrado del CSIC

    E-print Network

    FRONTERAS EN CIENCIA DE MATERIALES Curso de postgrado del CSIC 6 -22 abril 2015 6-20 abril: clases teóricas 21-22 abril: prácticas Curso de introducción a la investigación en las fronteras del conocimiento en ciencia de materiales. El curso está configurado como una serie de clases impartidas por expertos

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    E-print Network

    Secretaría Técnica del Curso Departamento de Química Aplicada Universidad Pública de Navarra://www.adsorcion.com/jarandilla Directores del Curso Julián J. Garrido Segovia Universidad Pública de Navarra Mariano Laguna Castrillo Bernalte García Departamento de Química Inorgánica. Curso de especialización Organizado por Grupo

  11. SALUTO DEL MAGNIFICO RETTORE DELL'UNIVERSITA' DEGLI STUDI DI TRENTO PRONUNCIATA IN OCCASIONE DEL CONFERIMENTO DELLA LAUREA AD

    E-print Network

    Moschitti, Alessandro

    Premio Nobel insieme a Daniel Kahneman, inizia con una citazione del grande fisico sperimentale Robert Millikan, con la quale vorrei terminare: " La scienza cammina su due piedi, la teoria e gli esperimenti

  12. Resultados de la primera etapa del Concurso IDi4Biz emprendedores Cinvestav Con fundamento en lo dispuesto en las bases de la convocatoria del Concurso IDi4Biz

    E-print Network

    Resultados de la primera etapa del Concurso IDi4Biz® emprendedores Cinvestav Con fundamento en lo dispuesto en las bases de la convocatoria del Concurso IDi4Biz® emprendedores Cinvestav, publicadas en el administrativamente con todos los requisitos estipulados para la primera etapa del Concurso IDi4Biz® emprendedores

  13. 165MAGALLANIA (Chile), 2015. Vol. 43(1):165-189 Universidad de Magallanes, Centro de Estudios del Hombre Austral del Instituto de la Patagonia. Av. Bulnes 01890, Punta

    E-print Network

    Kraus, Mary

    165MAGALLANIA (Chile), 2015. Vol. 43(1):165-189 * Universidad de Magallanes, Centro de Estudios del Hombre Austral del Instituto de la Patagonia. Av. Bulnes 01890, Punta Arenas, Chile. fabiana resultados de nuevos trabajos realizados en la cueva del Medio, Ultima Esperanza, Chile. Algunos de los

  14. BANDO 5 BORSE DI STUDIO PROGRAMMA LEONARDO MOBILITA' PLM VISTA la Decisione n. 1720/2006/CE del Parlamento Europeo e del Consiglio del 15

    E-print Network

    Pettenella, Davide

    programma LLP-Leonardo da Vinci e inerente alla mobilità di laureati per tirocini all'estero; VISTI gli programma LLP Leonardo da Vinci (People in the Labour Market) ed approvato dall'Unione Europea tramite l1 BANDO 5 BORSE DI STUDIO ­ PROGRAMMA LEONARDO MOBILITA' PLM VISTA la Decisione n. 1720/2006/CE del

  15. Uso del Los SIG en ModelosUso del Los SIG en ModelosUso del Los SIG en Modelos Hidrolgicos y de Calida de Agua

    E-print Network

    Gilbes, Fernando

    (Tomado con GPS) Modelo Digital de Elevación (DEM) ( ) #12;Definición de la Cuenca Hid áfi Definición de la Cuenca Hid áfiHidrográficaHidrográfica Modelo para Delinear Cuencas Hidrográficas #12;Definición de la Cuenca Hid áfi Definición de la Cuenca Hid áfiHidrográficaHidrográfica Dirección del Flujo

  16. Modelo semi-empírico de protuberancia solar a partir del diagnóstico de densidades

    NASA Astrophysics Data System (ADS)

    Cirigliano, D.; Vial, J. C.; Rovira, M.

    A partir de la observación del espectro del quintuplete de C III alrededor de 1175 Å, se ha realizado el diagnóstico de la densidad y presión electrónica, basado en el cálculo del cociente de las intensidades observadas. Una vez establecida la densidad electrónica, y con el cálculo de las velocidades Doppler, hemos investigado el flujo de masa en la protuberancia en función de la temperatura. Estableciendo como hipótesis la conservación del número de partículas que ingresan y salen del cuerpo de la protuberancia, se investiga la variación del área de un tubo de flujo semi-empírico en función de la temperatura. A partir de dicho diagnóstico, se examina el comportamiento del radio del tubo magnético en función de la temperatura, los que dan cuenta de la abertura de las líneas de campo magnético que confinan el plasma y de la divergencia del campo magnético en diferentes alturas de la atmósfera solar.

  17. El diseño final del espectrógrafo de banco (EBASIM) para CASLEO

    NASA Astrophysics Data System (ADS)

    Simmons, J.; Levato, H.

    Utilizando el código de óptica ACCOS V se ha finalizado el diseño del espectrógrafo de banco para CASLEO. En una comunicación anterior habíamos indicado que utilizaríamos un colimador de 150 mm de diámetro con un radio de curvatura de 1540 mm. Para el espejo cámara, que tiene un diámetro de 200 mm, el radio de curvatura es de 1200 mm, ambos radios con una tolerancia no mayor a los 3 mm. En la presente, se informa sobre los detalles finales del cálculo del espectrógrafo que incluye el cómputo para 5 longitudes de onda diferentes y alrededor de 100 rayos. En todos los casos el 75 % de energía está dentro de un diámetro de 13 micrones. El diseño ha sido probado entre 3500 Å hasta 9000 Å con resultados satisfactorios.

  18. Del T.U.C., su evolución y sus montajes.

    E-print Network

    Podesta A., Bruno

    1972-10-01

    FALL 1972 87 Del T.U.C, su evolución y sus montajes BRUNO PODESTÁ A. El Teatro de la Universidad Católica de Lima, Perú, (T.U.C.) se fundó el 22 de Junio de 1961. Desde entonces se han presentado 33 montajes y en el seno de la institución se...FALL 1972 87 Del T.U.C, su evolución y sus montajes BRUNO PODESTÁ A. El Teatro de la Universidad Católica de Lima, Perú, (T.U.C.) se fundó el 22 de Junio de 1961. Desde entonces se han presentado 33 montajes y en el seno de la institución se...

  19. 33 CFR 162.40 - Inland waterway from Delaware River to Chesapeake Bay, Del. and Md. (Chesapeake and Delaware Canal).

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...waterway from Delaware River to Chesapeake Bay, Del. and Md. (Chesapeake and Delaware...waterway from Delaware River to Chesapeake Bay, Del. and Md. (Chesapeake and Delaware...waterway from Delaware River to Chesapeake Bay, Del. and Md., between Reedy...

  20. 33 CFR 334.110 - Delaware Bay off Cape Henlopen, Del.; naval restricted area.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...2010-07-01 false Delaware Bay off Cape Henlopen, Del.; naval restricted area. 334.110 Section...DANGER ZONE AND RESTRICTED AREA REGULATIONS § 334.110 Delaware Bay off Cape Henlopen, Del.; naval restricted area. (a) The...

  1. El Instituto Nacional del Cáncer de EE. UU. y Perú firman una Declaración de Intención

    Cancer.gov

    El Instituto Nacional del Cáncer y la República del Perú firmaron una declaración de intención para compartir el interés en fomentar la investigación biomédica de oncología, basándose en la colaboración mutua de ambas entidades, así como el objetivo común

  2. BOLETN OFICIAL DEL ESTADO Nm. 130 Mircoles 1 de junio de 2011 Sec. I. Pg. 53970

    E-print Network

    Fitze, Patrick

    en la Unión Europea. Desde la entrada en vigor del Tratado de Ámsterdam, el 1 de mayo de 1999 y del Tratado de Lisboa, el 1 de diciembre de 2009, reconociendo el carácter jurídicamente vinculante de la

  3. BOLETN OFICIAL DEL ESTADO Nm. 219 Sbado 12 de septiembre de 2015 Sec. I. Pg. 80445

    E-print Network

    Verschure, Paul

    Básico del Empleado Público incrementándolos igualmente en función de la antigüedad. cve:BOE-A-2015-9801 Verificableenhttp://www.boe.es #12;BOLETÍN OFICIAL DEL ESTADO Núm. 219 Sábado 12 de septiembre de 2015 Sec. I. Pág

  4. Centro para la Salud Mundial del NCI anuncia becas de investigación para tecnologías portátiles

    Cancer.gov

    El Centro para la Salud Mundial del NCI (CGH) anunció el otorgamiento de subvenciones que apoyarán el desarrollo y la validación de tecnologías portátiles y de bajo costo para mejorar la detección temprana, el diagnóstico y el tratamiento del cáncer.

  5. 33 CFR 162.200 - Marina del Rey, Calif.; restricted area.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ...Navigable Waters 2 2010-07-01 2010-07-01 false Marina del Rey, Calif.; restricted area. 162.200 Section...SAFETY INLAND WATERWAYS NAVIGATION REGULATIONS § 162.200 Marina del Rey, Calif.; restricted area. (a) The...

  6. 33 CFR 162.200 - Marina del Rey, Calif.; restricted area.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ...Navigable Waters 2 2011-07-01 2011-07-01 false Marina del Rey, Calif.; restricted area. 162.200 Section...SAFETY INLAND WATERWAYS NAVIGATION REGULATIONS § 162.200 Marina del Rey, Calif.; restricted area. (a) The...

  7. MUJERES E IGUALDAD EN EL DEPORTE DEL 13 AL 17 DE JULIO

    E-print Network

    MUJERES E IGUALDAD EN EL DEPORTE DEL 13 AL 17 DE JULIO San Lorenzo de El Escorial Directora: Isabel. Periodista experta en género; Paloma Soroa. Periodista TVE; Milagros Díaz Díaz. Directora gerente del

  8. Conference Report: El teatro en el XVII Congreso del IILI en Filadelfia

    E-print Network

    Gutié rrez de la Solana, Alberto

    1976-04-01

    las que se leyeron los siguientes trabajos (citados en el orden del programa): Alberto Guitérrez de la Solana (NYU), "Huellas surrealistas en el teatro de Roberto Arlt." Enrique A. Giordano (Barnard College), "Sentido e importancia del juego en La... las que se leyeron los siguientes trabajos (citados en el orden del programa): Alberto Guitérrez de la Solana (NYU), "Huellas surrealistas en el teatro de Roberto Arlt." Enrique A. Giordano (Barnard College), "Sentido e importancia del juego en La...

  9. El sexagésimo aniversario del Teatro Experimental de la Universidad de Chile

    E-print Network

    Piga, Domingo

    2001-04-01

    sptiembre de 1973. Destaco el momento histórico político-social-económico que produjo nuestra generación del 41, los nombres del rector fundador Juvenal Hernández, y del actor Lucho Córdoba, el de Pedro de la Barra y tantos que han sido pilares sobre los... del Campo). ¿Qué importaba que Pedro de la Barra, SPRING 2001 193 o Parada o Miranda fueran unos pocos años mayores si respondían a los mismos valores humanos, sociales, culturales, ideológicos y artísticos que los que éramos un poco menores...

  10. Síntesis: Resultados iniciales del Estudio Nacional de Ex

    Cancer.gov

    El 4 de noviembre de 2010, el Estudio Nacional de Exámenes de Pulmóndio a conocer resultados iniciales que indican que hubo 20% menos muertes por cáncer de pulmón entre los participantes del estudio evaluados con tomografía computarizada espiral de baja d

  11. Determinacion de Caracteristicas Opticas del Telescopio OAN150

    NASA Astrophysics Data System (ADS)

    Galan, M. J.; Cobos, F. J.

    1987-05-01

    En el Observatorio de Calar Alto, en Almería, España, está ubicado un telescopio de 15O-cms de diámetro -construído por REOSC- perteneciente al Observatorio Astronómico Nacional, con sede en Madrid, España. La infraestructura técnica del OAN ha sido tradicionalmente débil y actualmente se está haciendo un esfuerzo por fortalecerla. Existe una información muy limitada del telescopio en general; de su óptica en particular se conocían los valores de los parámetros principales pero sin saber si éstos corresponden a valores teóricos ó de construcción. Por ello se consideró necesario iniciar una investigación para conocer en detalle los valores reales de las componentes ópticas del telescopio, obteniéndose algunos resultados de interés. El primario del telescopio OANl5O es aproximadamente F/3 y el siste ma en su conjunto es F/8.2, con su sistema corrector de campo. En términos generales, la imagen es satisfactoria en todo el campo y, sin sistema corrector, la imagen axial también es buena. En un futuro muy cercano se piensa diseñar instrumentación adicional para este telescopio. Conocer con mayor precisión sus características puede ser de gran utilidad para tal fin, pues se efectúan los cálculos considerando conjuntamente al telescopio y al instrumento.

  12. Sumarios del PDQ® de información sobre el cáncer

    Cancer.gov

    Los sumarios del PDQ de información de cáncer proveen información revisada por expertos con base en comprobación científica sobre tópicos que incluyen el tratamiento de cáncer en adultos y niños, cuidados médicos de apoyo, prevención, exámenes de detección, genética y medicina complementaria y alternativa, por lo general en formato para pacientes y profesionales de salud.

  13. Se lanza Red Nacional de Estudios Clínicos del NCI

    Cancer.gov

    El Instituto Nacional del Cáncer (NCI) puso en marcha una nueva red de investigación de estudios clínicos con el objetivo de mejorar el tratamiento de más de 1,6 millones de estadounidenses que reciben un diagnóstico de cáncer cada año.

  14. Estimados de diversidad de rboles del Bosque Seco de

    E-print Network

    Gilbes, Fernando

    terreno, suelo y topografía. · Se corrieron modelos para las especies presentes en 10 o mas parcelas (23 especies) #12;Datos ambientales · Tipos de suelos · Distancia desde canales naturales de desagüe de lluvias (índice de humedad en el suelo) · Varios parámetros extraídos del modelo digital de elevación ­ Elevación

  15. Guia per a l's no sexista del llenguatge

    E-print Network

    Daniilidis, Aris

    que els substantius (i els adjectius, els articles i els pronoms) en aquestes llengües varien segons aquesta categoria gramatical. En el cas del català, tenim dos gèneres, el masculí i el femení, que són els gènere amb el sexe. El gènere és una categoria gramatical que fa referència a les paraules (pebre és una

  16. Elementi di Logica Matematica Prova scritta del 20 Gennaio 2015

    E-print Network

    Di Nasso, Mauro

    1. Calcolarne le cardinalit`a. 2. Calcolare i cardinali che si ottengono considerando le esponenziazioni di sopra come esponenzia- zioni tra cardinali (cio`e ponendo 0 al posto di , 1 al posto di 1, 2 al- frontabilit`a. 4. Assumendo l'ipotesi generalizzata del continuo, specificare quali dei cardinali trovati nel

  17. Control del dolor: Apoyo para las personas con cáncer

    Cancer.gov

    Contiene información sobre las medicinas contra el dolor para pacientes con cáncer, los planes para controlarlo, cómo hablar con su equipo de atención médica sobre el dolor que usted siente y qué hacer para controlar los efectos físicos y emocionales del

  18. Design, aerodynamics and autonomy of the DelFly.

    PubMed

    de Croon, G C H E; Groen, M A; De Wagter, C; Remes, B; Ruijsink, R; van Oudheusden, B W

    2012-06-01

    One of the major challenges in robotics is to develop a fly-like robot that can autonomously fly around in unknown environments. In this paper, we discuss the current state of the DelFly project, in which we follow a top-down approach to ever smaller and more autonomous ornithopters. The presented findings concerning the design, aerodynamics and autonomy of the DelFly illustrate some of the properties of the top-down approach, which allows the identification and resolution of issues that also play a role at smaller scales. A parametric variation of the wing stiffener layout produced a 5% more power-efficient wing. An experimental aerodynamic investigation revealed that this could be associated with an improved stiffness of the wing, while further providing evidence of the vortex development during the flap cycle. The presented experiments resulted in an improvement in the generated lift, allowing the inclusion of a yaw rate gyro, pressure sensor and microcontroller onboard the DelFly. The autonomy of the DelFly is expanded by achieving (1) an improved turning logic to obtain better vision-based obstacle avoidance performance in environments with varying texture and (2) successful onboard height control based on the pressure sensor. PMID:22617112

  19. I quaderni del Marconi La Biomatematica in un problema

    E-print Network

    Zuccher, Simone

    ;3 Presentazione L'ITIS Marconi è stato scelto, per l'a.s. 2005/2006, come scuola Polo per l'attua- zione del Gabriela Freddo Giorgia Marchetto Giacomo Banterle Marco Furlani Dimitri Ruffo Massimiliano Battiston Mattia Gaiga Michele Segna Tommaso Benasi Plinio Longo Marco Scandola Luca Castellani Federico Lorenzi

  20. 7. Saturn Atmospheric Structure and Dynamics Anthony D. Del Genio

    E-print Network

    7. Saturn Atmospheric Structure and Dynamics Anthony D. Del Genio NASA Goddard Institute for Space, AZ 85721 #12;2 Abstract Saturn inhabits a dynamical regime of rapidly rotating, internally heated outbreaks near 35°S associated with Saturn electrostatic discharges, and in sporadic giant equatorial storms

  1. ARTICULATED MOTION ANALYSIS FROM MOTION CAPTURE , A. Del Bue2

    E-print Network

    Aguiar, Pedro M. Q.

    ARTICULATED MOTION ANALYSIS FROM MOTION CAPTURE DATA J. Fayad1 , A. Del Bue2 and P. M. Q. Aguiar3 1-defined a priori models of the skeleton. Such data-driven models are useful in the analysis of human walk, which can be troublesome. Alternatively one can use anthropometric tables to extract statistical

  2. Faculty Activity Analysis in the Universidad Tecnica Del Estado Campuses.

    ERIC Educational Resources Information Center

    Karadima, Oscar

    An analysis of academic activities of college faculty at the eight campuses of Chile's Universidad Tecnica del Estado was conducted. Activities were grouped into seven categories: direct teaching, indirect teaching, research, community services, faculty development, academic administration, and other activities. Following the narrative…

  3. Al Direttore del Dipartimento di Scienze della Terra

    E-print Network

    sensi degli artt. 46 e 47 del D.P.R. 28 dicembre2000 n. 445, consapevole delle seguente documento d'identità2 : carta d'identità, n. AK544503, rilasciato da Ministry seguente documento d'identità2 : carta d'identità, n. AK544503, rilasciato da Ministry

  4. Interdisciplinary Unit: La Isla del Encanto (The Enchanted Island).

    ERIC Educational Resources Information Center

    Ford-Guerrera, Rebecca

    This document presents a series of 14 lesson plans in an interdisciplinary Spanish unit on "La isla del encanto/The Enchanted Island." The materials were prepared for students in grades 5 or 6 who have had basic Spanish instruction in previous grades. The students should also be familiar with basic concepts in English such as math computation, map…

  5. Ingeniera Cuntica Mdulo 3 del Curso de Actualizacin 2007

    E-print Network

    Rosas-Ortiz, Jose Oscar

    Ingeniería Cuántica Módulo 3 del Curso de Actualización 2007 ITESM Ponente: Oscar Rosas exposición de 10 min. La nota se establecerá en base a la participación durante el curso de cada asistente y a la exposición de equipo. Programa: El curso está integrado por tres capítulos, cada uno de ellos

  6. Seasonal distribution of freshwater dolphins in Tipishca Del Samiria, Peru 

    E-print Network

    Zuniga, Elizabeth Luisa

    1999-01-01

    in Brazil. Forty-two species of fish were identified from casual observation of fish catches in Tipishca del Samiria. Seven of these species are know from the literature to have been found in stomach contents of botos and tucuxis necropsied further downriver...

  7. Elementi di Logica Matematica Prova scritta del 18 Ottobre 2006

    E-print Network

    Di Nasso, Mauro

    insiemi: 1. X1 = {f : A R | A R finito }, cio`e l'insieme di tutte le funzioni a valori reali aventi come dominio un insieme finito di reali. 2. X2 = {A R | |A| = |R \\ A| = |R|}, cio`e l'insieme di tutti i sottoinsiemi di numeri reali aventi la potenza del continuo e il cui complementare abbia anch

  8. Del Mod: A State-Wide System for School Improvement.

    ERIC Educational Resources Information Center

    Neale, Daniel C.

    This is a retrospective account of the Del Mod System, a statewide project to improve science and mathematics education in the elementary and secondary schools of Delaware. The project functioned from 1970-76 under the auspices of a committee including the presidents of institutions of higher education, the state superintendent of public…

  9. Temario del curso bsico de topologa I Conceptos Fundamentales

    E-print Network

    grupos topológicos. Teorema del punto fijo de Brouwer en dimensión 2 IV Complejos Celulares 1. Topologías cociente y espacios de adjunción 2. Complejos celulares y paracompacidad 3. Descomposición celular de. Descomposición celular de variedades de Stiefel y de Grassmann 6. Extensión de funciones (cf. Teorema de Tietze

  10. Middleware Laboratory Il passaggio del tempo nei sistemi distribuiti

    E-print Network

    Tucci, Sara

    1 Middleware Laboratory Il passaggio del tempo nei sistemi distribuiti Middleware Laboratory Il tempo 1 Il tempo nei sistemi distribuiti WARNING: In un sistema distribuito e' impossibile avere un un ordine totale di eventi se si considera il tempo al quale sono stati generati Per molti problemi

  11. 23 de junio de 2015 RENOVACIN DEL CONSEJO DE GOBIERNO

    E-print Network

    Cardeñosa, Jesús

    Telecomunicación Sánchez Gálvez, Vicente ETSI Caminos, Canales y Puertos Sancho Aznal, José María ETS Arquitectura, César ETS Arquitectura Casati Calzada, Mª Jesús ETSI Aeronáutica y del Espacio González Aguado, Mª Arquitectura Pastor Martín, Mª Encarnación ETSI Telecomunicación Taguas Coejo, Francisco Javier ETSI Agrónomos

  12. Pierre Del Moral Date of birth: January 7th, 1965 (Nationality: French).

    E-print Network

    Del Moral , Pierre

    @unsw.edu.au, Pierre.Del-Moral@inria.fr URL: http://web.maths.unsw.edu.au/peterdel-moral/ · Education : ­ Higher DegreePierre Del Moral Date of birth: January 7th, 1965 (Nationality: French). Male, Married with two Wales High Street, Kensington, SYDNEY, NSW 2052 Phone : +61 (2) 93 85 69 00 Emails: p.del-moral

  13. MODELADO DE LA DINMICA DEL CARBONO ORGNICO EN SUELOS USANDO INFORMACIN ISOTPICA: APLICACIN EN PASTIZALES FORESTADOS

    E-print Network

    Nacional de San Luis, Universidad

    MODELADO DE LA DINÁMICA DEL CARBONO ORGÁNICO EN SUELOS USANDO INFORMACIÓN ISOTÓPICA: APLICACIÓN EN) Dept. Biology, Duke University, Durham NC 27708 (EE.UU.) Introducción Los suelos alojan el mayor orgánico del suelo (COS) tiene en el ciclo global del elemento, la comprensión de su intercambio con otros

  14. MOHAMED ELBARADEI El Dr. Mohamed ElBaradei es el Director General del Organismo

    E-print Network

    Cardeñosa, Jesús

    Presidente del colegio de abogados de Egipto. En 1962 obtuvo una licenciatura en derecho de la Universidad de El Cairo y, en 1974, un doctorado en derecho internacional de la Facultad de Derecho de la de las Naciones Unidas sobre el Derecho del Mar, la Organización Internacional del Trabajo, la

  15. Disposizione n. 791/2015 Prot. n. 0014266 del 27/02/2015

    E-print Network

    Di Pillo, Gianni

    Disposizione n. 791/2015 Prot. n. 0014266 del 27/02/2015 Classif. VII/1 AREA RISORSE UMANE UFFICIO PERSONALE TECNICO-AMMINISTRATIVO SETTORE Concorsi personale TAB Universitario e CEL Il Direttore dell'Area Risorse Umane VISTI la disposizione del Direttore dell'Area Risorse Umane n. 3368/2014, prot. 0045129 del

  16. del Moral Bibliography Mount St. Helens RECENT RESEARCH PAPERS (links to available papers are provided)

    E-print Network

    del Moral, Roger

    del Moral Bibliography Mount St. Helens RECENT RESEARCH PAPERS (links to available papers are provided): del Moral, R. & J. H. Titus. 2015 (in Press). Primary Succession on Mount St. Helens: Rates, R. del Moral & K. Prach. 2014. Optimization of Intervention levels in ecological restoration

  17. A Backward Particle Interpretation of Feynman-Kac P. Del Moral

    E-print Network

    Del Moral , Pierre

    A Backward Particle Interpretation of Feynman-Kac Formulae P. Del Moral Centre INRIA de Bordeaux. Cambridge University, Engineering Dpt. (2009). P. Del Moral (INRIA) INRIA Bordeaux-Sud Ouest 1 / 28 #12 functionals P. Del Moral (INRIA) INRIA Bordeaux-Sud Ouest 2 / 28 #12;Summary 1 Introduction, motivations Some

  18. Concentration inequalities for mean field particle models P. Del Moral & E. Rio

    E-print Network

    Del Moral , Pierre

    Concentration inequalities for mean field particle models P. Del Moral & E. Rio INRIA Centre. JRSS B (2006). P. Del Moral, E. Rio (INRIA Bordeaux) 1 / 29 #12;Outline 1 Introduction Some notation Concentration inequalities P. Del Moral, E. Rio (INRIA Bordeaux) 2 / 29 #12;Outline 1 Introduction Some notation

  19. Some theoretical aspects of Particle/SMC Methods P. Del Moral

    E-print Network

    Del Moral , Pierre

    Some theoretical aspects of Particle/SMC Methods P. Del Moral INRIA, Centre Bordeaux-Sud Ouest), + References DM, Doucet, Jasra. SMC Samplers. JRSS B (2006). P. Del Moral (INRIA Bordeaux) INRIA Centre. Del Moral (INRIA Bordeaux) INRIA Centre Bordeaux-Sud Ouest, France 2 / 47 #12;Summary 1 Some

  20. Concentration for Mean Field Particle Models P. Del Moral, E. Rio

    E-print Network

    Del Moral , Pierre

    Concentration for Mean Field Particle Models P. Del Moral, E. Rio ALEA team project : Centre INRIA + N. Hadjiconstantinou. M2AN, vol 44, no. 5 (2010) P. Del Moral, E. Rio (INRIA) INRIA Bordeaux P. Del Moral, E. Rio (INRIA) INRIA Bordeaux-Sud Ouest 2 / 26 #12;Summary 1 Introduction, motivations

  1. Concentration for Mean Field Particle Models P. Del Moral, E. Rio

    E-print Network

    Del Moral , Pierre

    Concentration for Mean Field Particle Models P. Del Moral, E. Rio Centre INRIA de Bordeaux - Sud Interpretation of Feynman-Kac Formulae HAL-INRIA RR-7019 (09). To appear in M2AN (2010) P. Del Moral, E. Rio models 3 Convergence analysis P. Del Moral, E. Rio (INRIA) INRIA Bordeaux-Sud Ouest 2 / 23 #12;Summary 1

  2. An introduction to particle simulation of rare events P. Del Moral

    E-print Network

    Del Moral , Pierre

    An introduction to particle simulation of rare events P. Del Moral Centre INRIA de Bordeaux - Sud Ouest Workshop OPUS, 29 juin 2010, IHP, Paris P. Del Moral (INRIA) INRIA Bordeaux-Sud Ouest 1 / 33 #12 Stochastic models and methods 5 Some convergence results 6 Some references P. Del Moral (INRIA) INRIA

  3. Anlisis de cambios en la calidad del agua en Puerto Rico utilizando Sistemas de

    E-print Network

    Gilbes, Fernando

    Análisis de cambios en la calidad del agua en Puerto Rico utilizando Sistemas de Información;Agradecimientos · Calidad del agua (Puerto Rico) ­ Maria Uriarte de Columbia University ­ Charles B. Yackulic , Yili Lim · Calidad del agua (Cuenca Guavate) ­ Keyla Torres, Elizabeth Pabón y Fredmarie Oyola

  4. PETRLEO EN EL MAR ABIERTO La presencia de petrleo en el agua del mar puede

    E-print Network

    AGUA Y SEDIMENTOS · Monitoreo de la calidad del agua · Encuestas para detectar petróleo debajo de la actividades necesarias para restaurar el Golfo de México. PRUEBAS DE CALIDAD DEL AGUA ESTUDIOS DE CAMPOPETRÓLEO EN EL MAR ABIERTO La presencia de petróleo en el agua del mar puede afectar la salud de

  5. Conozca cuáles son las opciones de atención del cáncer en su comunidad

    Cancer.gov

    Este artículo hace una presentación general de las funciones del programa de centros oncológicos designados por el NCI y del programa de investigación oncológica comunitaria del NCI en Estados Unidos, los cuales son una fuente importante de atención para pacientes con cáncer.

  6. TTULO DEL CURSO: LA RESPONSABILIDAD SOCIAL DE LAS EMPRESAS EN EL CONTEXTO DE LA CRISIS FINANCIERA

    E-print Network

    Escolano, Francisco

    TÍTULO DEL CURSO: LA RESPONSABILIDAD SOCIAL DE LAS EMPRESAS EN EL CONTEXTO DE LA CRISIS FINANCIERA 11, 12 y 13 de julio de 2011 Universidad de Alicante. Seu la Nucia. Organización del curso: Director del curso: Eliseo Fernández Daza Secretaría Académica: Ramón Dangla, Remedios Patrocinadores: #12

  7. Forensic Performance of Short Amplicon Insertion-Deletion (InDel) Markers

    E-print Network

    HID-38plex and DIPplex. - Independence of the markers. 3- Results - Allele frequency analysisDel Polymorphisms: Introduction and Concept. 2- Materials and Methods: - InDel assays HID-38plex and DIPplex amplicons HID-38plex R. Pereira et al Electrophoresis (2009) · 38plex PCR · 38 InDel markers (on 22

  8. Guatemala: Parque Nacional Sierra del Lacandn www.parkswatch.org 1

    E-print Network

    Lopez-Carr, David

    Guatemala: Parque Nacional Sierra del Lacandón www.parkswatch.org 1 Parque Nacional Sierra del al norte de Guatemala, en el oeste del municipio de la Libertad, Departamento de Petén. Creado en el segundo parque nacional más grande de Guatemala. Ha sido caracterizado, junto con el Parque

  9. Jornadas Tcnicas Forestales y Ambientales FCF, UNaM EEA Montecarlo, INTA EFECTOS DEL PARASITISMO DEL NEMATODO Beddingia (=Deladenus) siricidicola

    E-print Network

    Sirex noctilio EFFECTS OF THE NEMATODE Beddingia (=Deladenus) siricidicola PARASITISM IN ADULTS STAGE OF WOOD WASP Sirex noctilio Edgar R. Eskiviski 1 Gabriela Faraldo 2 Olga del R. de Coll 3 1 - Ing. Ftal. E@ceel.com.ar SUMMARY The nematode Beddingia siricidicola is the most important agent for the biological control

  10. Estrategia innovadora enfocada en parejas del mismo sexo para disminuir la infección del VIH en hombres Latinos

    PubMed Central

    Martinez, Omar; Wu, Elwin; Sandfort, Theo; Shultz, Andrew Z.; Capote, Jonathan; Chávez, Silvia; Moya, Eva; Dodge, Brian; Morales, Gabriel; Porras, Antonio; Ovejero, Hugo

    2014-01-01

    Resumen El VIH es un problema de salud importante dentro de la comunidad latina de los Estados Unidos. Gracias a los esfuerzos de prevención, los niveles de contagio entre los latinos se han mantenido estables por más de una década. Sin embargo, esta población sigue siendo afectada a niveles muy altos, en particular entre hombres que tienen sexo con hombres (HSH), de origen latino y que hablan principalmente el idioma español. Existen varios factores que contribuyen a la transmisión del VIH entre esta población, como son: el uso de drogas; la violencia dentro de la pareja; la presencia de infecciones de transmisión sexual; relaciones sexuales sin protección, dentro y fuera de la pareja; el evadir la búsqueda de recursos (prueba y tratamiento adecuado) por temor a ser discriminado o por su estatus migratorio; la escasez de recursos económicos o estado de pobreza y los patrones relacionados a la migración. En particular, Investigaciones Epidemiológicas de Comportamientos han determinado: cómo algunas dinámicas en parejas están directamente asociadas a los comportamientos sexuales de riesgos. En consecuencia, es necesaria mayor investigación para identificar esas dinámicas, y a su vez, realizar intervenciones dirigidas a la reducción de conductas de riesgo enfocadas en parejas de hombres del mismo sexo. En este escrito, se describe la importancia del uso de las relaciones de pareja como estrategia en la reducción de la trasmisión del VIH/SIDA en HSH de origen latino y que hablan principalmente el idioma español en los Estados Unidos. PMID:25580466

  11. VULNERABILIDAD SOCIAL DE LAS COMUNIDADES AL CAMBIO CLIMTICO (ASCENSO DEL NIVEL DEL MAR, INUNDACIONES Y SALINIDAD) EN LA CUENCA

    E-print Network

    Gilbes, Fernando

    comunidades de la cuenca del río Piedras, principal cuerpo de agua de la ciudad de San Juan, Puerto Rico las inundaciones y los efectos de éstos parámetros sobre su salud, propiedad y calidad de vida. Se Global (SPG) y datos procedentes de un muestreo de agua para salinidad, conductividad, PH, oxígeno

  12. DIRECTIVA 2002/96/CE DEL PARLAMENTO EUROPEO Y DEL CONSEJO de 27 de enero de 2003

    E-print Network

    Autonoma de Madrid, Universidad

    Tratado constitutivo de la Comunidad Europea, y en particular el apartado 1 de su artículo 175, Vista la Tratado (4 ), a la vista del texto conjunto aprobado por el Comité de Conciliación el 8 de noviembre de

  13. Cdigo del Proyecto: FCE_2_2011_1_6739 Ttulo del Proyecto: Grafos aleatorios y lmites fluidos

    E-print Network

    el modelado de redes inalámbricas Línea de financiamiento a la que postula: Investigación Fundamental español: Grafos aleatorios y límites fluidos en el modelado de redes inalámbricas Palabras clave en español: Modelado, Redes, Inalámbricas Título del proyecto en inglés: Random graphs and fluid limits

  14. Tabla I. Descripcin del trabajo realizado por eje estratgico del proyecto Eje Estratgico Mejora docente y adaptacin al EEES

    E-print Network

    Verschure, Paul

    puesta en marcha de los cursos masivos gratuitos en línea (MOOC) y a la formación y capacitación docente. - Se ha incentivado la puesta en marcha de los cursos MOOC, donde destaca el rol de la Fundación TecnoCampus, agregación destacada del CEI en docencia y pionera en este tipo de cursos (a modo de ejemplo, el curso

  15. LO SABA?... Jobbagy, Mercau & Nosetto

    E-print Network

    Nacional de San Luis, Universidad

    zona saturada (todos los poros ocupados por agua) del perfil de un suelo/sedimento. Los hidrólogos las Verdadera. ZONA CAPILAR 1 El agua asciende sobre la altura de la napa por los capilares del suelo. En.0-1.5 m por sobre la napa. En suelos más arenosos hasta 0.5-1.0 m. En suelos más arcillosos la tasa de

  16. Modernidad de la Antigedad (III): Recepcin y recreacin del legado grecolatino El curso mantiene la continuidad con los ofrecidos en los ltimos aos, haciendo hincapi en los procesos de transmisin del

    E-print Network

    Modernidad de la Antigüedad (III): Recepción y recreación del legado grecolatino El curso mantiene a recurrir a referentes antiguos. El curso busca ampliar el conocimiento de esta tradición para hacer patente ciencia, pervivencia y recepción, y reelaboración. Título del curso Resumen del contenido y objeto del

  17. Analisis del contenido curricular de los Documentos Normativos del Programa de Ciencias en el area de biologia para la escuela superior del sistema de educacion publica de Puerto Rico: 1993-2012

    NASA Astrophysics Data System (ADS)

    Davila Montanez, Melissa

    Esta investigacion de naturaleza cualitativa se ocupo de realizar un analisis de contenido documental de los Documentos Normativos del Programa de Ciencias en el area de biologia de la escuela superior del sistema de educacion publica de Puerto Rico del periodo 1993-2012. Los documentos analizados fueron: Guia Curricular, 1995; Marco Curricular, 2003; Estandares de Excelencia, 1996, 2000 y Estandares de Contenido y Expectativas de Grado, 2007. Se indago si hubo cambios en significados en los Componentes Estructurales: Naturaleza de la ciencia, Paradigmas para la ensenanza de la ciencia, Funcion del curriculo formal, Mision de la ensenanza de la ciencia; Contenidos, destrezas y competencias, Estrategias de ensenanza y Evaluacion/Assessment del aprendizaje. El analisis sugiere que no hubo cambios sustanciales en los significados de los Componentes Estructurales. Los documentos estudiados muestran mayormente caracteristicas similares, aunque los documentos mas recientes eran mas descriptivos, explicativos y especificos.

  18. Genomic Copy Number Variations in the Myelodysplastic Syndrome and Acute Myeloid Leukemia Patients with del(5q) and/or -7/del(7q)

    PubMed Central

    Zhang, Rui; Kim, Young-Mi; Wang, Xianfu; Li, Yan; Lu, Xianglan; Sternenberger, Andrea R.; Li, Shibo; Lee, Ji-Yun

    2015-01-01

    The most common chromosomal abnormalities in myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) are -5/del(5q) and -7/del(7q). When -5/del(5q) and -7/del(7q) coexist in patients, a poor prognosis is typically associated. Given that -5/del(5q) and/or -7/del(7q) often are accompanied with additional recurrent chromosomal alterations, genetic change(s) on the accompanying chromosome(s) other than chromosomes 5 and 7 may be important factor(s) affecting leukemogenesis and disease prognosis. Using an integrated analysis of karyotype, FISH and array CGH results in this study, we evaluated the smallest region of overlap (SRO) of chromosomes 5 and 7 as well as copy number alterations (CNAs) on the other chromosomes. Moreover, the relationship between the CNAs and del(5q) and -7/del(7q) was investigated by categorizing the cases into three groups based on the abnormalities of chromosomes 5 and 7 [group I: cases only with del(5q), group II: cases only with -7/del(7q) and group III: concurrent del(5q) and del(7q) cases]. The overlapping SRO of chromosome 5 from groups I and III was 5q31.1-33.1 and of chromosome 7 from groups II and III was 7q31.31-q36.1. A total of 318 CNAs were observed; ~ 78.3% of them were identified on chromosomes other than chromosomes 5 and 7, which were defined as 'other CNAs'. Group III was a distinctive group carrying the most high number (HN) CNAs, cryptic CNAs and 'other CNAs'. The loss of TP53 was highly associated with del(5q). The loss of ETV6 was specifically associated with group III. These CNAs or genes may play a secondary role in disease progression and should be further evaluated for their clinical significance and influence on therapeutic approaches in patients with MDS/AML carrying del(5q) and/or -7/del(7q) in large-scale, patient population study. PMID:26392809

  19. Modelado de los cambios de uso/cobertura del suelo y conservacin de la biodiversidad en Michoacn

    E-print Network

    Lopez-Carr, David

    1 Modelado de los cambios de uso/cobertura del suelo y conservación de la biodiversidad en). Varios estudios se abocaron a evaluar los cambios de uso/cobertura del suelo (CUCS) en México (Mas et al MATERIALES Los insumos cartográficos fueron los mapas de uso/cobertura del suelo del Instituto Nacional de

  20. Localizador de Servicios de Apoyo - Instituto Nacional del Cáncer

    Cancer.gov

    HealthCare.gov es el primer centro de datos de alternativas de cobertura médica del Departamento de Salud y Servicios Humanos de EE. UU. que combina los programas públicos (ej. Medicare, Medicaid) con la información de más de 1 000 planes de seguros privados. El usuario puede buscar en Internet las opciones de cobertura médica específicas a su situación y a su comunidad local. Igualmente, Healthcare.gov tiene información sobre la reforma sanitaria Affordable Care Act.

  1. La profesionalización del teatro nacional argentino. Un precursor: Nemesio Trejo

    E-print Network

    Pellarolo, Silvia

    1997-10-01

    ansias de legalizar su trabajo como profesionales de teatro. Entre los precursores, me interesa destacar la participación activa del sainetista criollo Nemesio Trejo en la creación de este tipo de asociaciones. El caso particularísimo de Trejo (nacido..., en el peor de los casos. El pago que recibían los autores por piezas teatrales que estaban enriqueciendo a los empresarios eran efectivamente muy bajos. Sin embargo, si se compara este pago con el casi nulo que percibían los poetas o narradores de...

  2. Descripción del coronógrafo a ser instalado en Argentina (MICA)

    NASA Astrophysics Data System (ADS)

    Stenborg, G.; Francile, C.; Schwenn, R.; Epple, A.; Rovira, M.

    El ``Coronógrafo de espejo para Argentina'' es un telescopio solar terrestre a ser colocado en el Observatorio Astronómico Félix Aguilar (El Leoncito), antes de finalizar 1996, como parte de un programa de ciencia bilateral entre Alemania y Argentina. Eclipses fotográficos de alta resolución han revelado que la corona solar es altamente estructurada y variable. De hecho, está contínuamente deformada y moldeada por los movimientos convectivos de los extremos de los arcos magnéticos en la fotosfera, estando, en muchas oportunidades, afectada por explosivas liberaciones de energía. MICA, en conjunción con otros telescopios solares espaciales y terrestres, tratará de contribuir al entendimiento de cuestiones fundamentales de la física solar. Entre ellas: cómo la corona está siendo calentada, dónde y cómo el viento solar es acelerado, qué causa los transitorios coronales, etc. Para ello investigará la distribución de los parámetros del plasma y su evolución con el tiempo, la estructura espacial de la corona en fina y gran escala, procesos que ocurren en los transitorios coronales y factores que los disparan, etc. Para responder a estas cuestiones MICA observará la atmósfera solar por sobre el limbo entre 1.1 y 2 radios solares aproximadamente, usando un nuevo tipo de sistema coronográfico que permite suprimir el brillo del disco solar suficientemente bien, tomando las imágenes con una cámara CCD de 1024x1024 pixels, codificada en 12 bits, pudiendo el mismo ser operado en forma remota. En la presente exposición describiremos las características del instrumento, cómo será controlado y qué esperamos observar basados en las imágenes obtenidas por los telescopios de similares características LASCO C1 a bordo del SOHO y PICO (ubicado en el Observatorio de Pic du Midi, Francia).

  3. Pío del Río Hortega and the discovery of the oligodendrocytes

    PubMed Central

    Pérez-Cerdá, Fernando; Sánchez-Gómez, María Victoria; Matute, Carlos

    2015-01-01

    Pío del Río Hortega (1882–1945) discovered microglia and oligodendrocytes (OLGs), and after Ramón y Cajal, was the most prominent figure of the Spanish school of neurology. He began his scientific career with Nicolás Achúcarro from whom he learned the use of metallic impregnation techniques suitable to study non-neuronal cells. Later on, he joined Cajal’s laboratory. and Subsequently, he created his own group, where he continued to develop other innovative modifications of silver staining methods that revolutionized the study of glial cells a century ago. He was also interested in neuropathology and became a leading authority on Central Nervous System (CNS) tumors. In parallel to this clinical activity, del Río Hortega rendered the first systematic description of a major polymorphism present in a subtype of macroglial cells that he named as oligodendroglia and later OLGs. He established their ectodermal origin and suggested that they built the myelin sheath of CNS axons, just as Schwann cells did in the periphery. Notably, he also suggested the trophic role of OLGs for neuronal functionality, an idea that has been substantiated in the last few years. Del Río Hortega became internationally recognized and established an important neurohistological school with outstanding pupils from Spain and abroad, which nearly disappeared after his exile due to the Spanish civil war. Yet, the difficulty of metal impregnation methods and their variability in results, delayed for some decades the confirmation of his great insights into oligodendrocyte biology until the development of electron microscopy and immunohistochemistry. This review aims at summarizing the pioneer and essential contributions of del Río Hortega to the current knowledge of oligodendrocyte structure and function, and to provide a hint of the scientific personality of this extraordinary and insufficiently recognized man. PMID:26217196

  4. 3. 1939 DROP STRUCTURE IN DEL MAR PARK SURMOUNTED BY ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. 1939 DROP STRUCTURE IN DEL MAR PARK SURMOUNTED BY RECENT PEDESTRIAN BRIDGE. - Highline Canal, Sand Creek Lateral, Beginning at intersection of Peoria Street & Highline Canal in Arapahoe County (City of Aurora), Sand Creek lateral Extends 15 miles Northerly through Araphoe County, City & County of Denver, & Adams County to its end point, approximately 1/4 mile Southest of intersectioin of D Street & Ninth Avenue in Adams County (Rocky Mountain Arsenal, Commerce City Vicinity), Commerce City, Adams County, CO

  5. 2. COURSE OF THE LATERAL THROUGH DEL NORTHWEST MAR PARK. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. COURSE OF THE LATERAL THROUGH DEL NORTHWEST MAR PARK. - Highline Canal, Sand Creek Lateral, Beginning at intersection of Peoria Street & Highline Canal in Arapahoe County (City of Aurora), Sand Creek lateral Extends 15 miles Northerly through Araphoe County, City & County of Denver, & Adams County to its end point, approximately 1/4 mile Southest of intersectioin of D Street & Ninth Avenue in Adams County (Rocky Mountain Arsenal, Commerce City Vicinity), Commerce City, Adams County, CO

  6. Caracteres del grupo aditivo de los racionales Elena Cillero Sanz

    E-print Network

    Martín Peinador, Elena

    todos los caracteres Hom(G, T), dotado de la topolog´ia de la convergencia puntual. Por ´ultimo a lo largo del trabajo. Al grupo aditivo de los n´umeros racionales dotado de la topolog´ia discreta Mart´in Peinador. 115 #12;Qu ser´a el grupo de los racionales dotado de la topolog´ia usual y Ru el

  7. Solar adaptive optics at the Observatorio del Teide, Tenerife

    NASA Astrophysics Data System (ADS)

    Soltau, Dirk; Berkefeld, Thomas; Schmidt, Dirk; von der Lühe, Oskar

    2013-10-01

    Observing the Sun with high angular resolution is difficult because the turbulence in the atmosphere is strongest during day time. In this paper we describe the principles of solar adaptive optics exemplified by the two German solar telescopes VTT and GREGOR at the Observatorio del Teide. With theses systems we obtain near diffraction limited images of the Sun. Ways to overcome the limits of conventional AO by applying multiconjugate adaptive optics (MCAO) are shown.

  8. Modeling Visibility in the EL Paso del Norte Region

    NASA Astrophysics Data System (ADS)

    Fitzgerald, R. M.; Medina, R.; DuBois, D. W.; Novlan, D.

    2013-12-01

    Poor visibility is a subject of growing public concern throughout the U.S, and an active area of research. Its societal impacts in air quality, aviation transport and traffic are significant. Aerosols play a fundamental role in the attenuation of solar radiation, and also affect visibility. The scattering and extinction coefficients of aerosol particles in the Paso del Norte Region have been calculated using the T- matrix model in conjunction with a laser particle counter. Inter-comparison of the model's results of the scattering and absorption coefficients against the corresponding data from a Photoacustic Extinctiometer instrument (which measures in-situ absorption and scattering coefficients of aerosol particles) shows excellent agreement. In addition, the volume-weighted method is used to determine the composite index of refraction which is representative of the aerosols for the Paso del Norte Airshed to obtain information of the type of aerosol particles present in the Airshed. The Single Scattering Albedo has also been retrieved using our methodology to obtain further insight into the type of aerosols present on a given day. Finally, the Koschmieder equation has been used to calculate the visual range or visibility, and was correlated with the PM2.5 and PM10 particle concentration present in the Airshed. Our methodology will allow a better understanding of the size and type of aerosol particles that are most detrimental to the visibility for the Paso del Norte Region.

  9. Modeling visibility in the Paso del Norte (PDN) Region

    NASA Astrophysics Data System (ADS)

    Medina Calderon, Richard

    Poor visibility is a subject of growing public concern throughout the U.S, and an active area of research. Its societal impacts on air quality, aviation transport and traffic are significant. Aerosols play a fundamental role in the attenuation of solar radiation, and also affect visibility. The scattering and extinction coefficients of aerosol particles in the Paso del Norte Region have been calculated using the T- matrix model in conjunction with a laser particle counter. Inter-comparison of the model's results of the scattering and absorption coefficients against the corresponding data from a Photoacustic extinctiometer instrument (which measures in-situ absorption and scattering coefficients of aerosol particles) shows excellent agreement. In addition, the volume-weighted method is used to determine the composite index of refraction which is representative of the aerosols for the Paso del Norte Region to obtain information of the type of aerosol particles present in the Region. The Single Scattering Albedo has also been retrieved using this methodology to obtain further insight into the type of aerosols present on a given day. Finally, the Koschmieder equation has been used to calculate the visual range or visibility, and was correlated with the PM2.5 and PM10 particle concentration present in the Region. Our methodology will allow a better understanding of the size and type of aerosol particles that are most detrimental to the visibility for the Paso Del Norte Region.

  10. Nuevo sitio web en español del Instituto Nacional del Cáncer, (NCI, por sus siglas en inglés) Cancer.gov en español - Silvia Inéz Salazar - transcript

    Cancer.gov

    Transmisiones de radio para promover Cancer.gov en espa%XF1ol | Nuevo sitio web en espa%XF1ol del Instituto Nacional del C%XE1ncer, (NCI, por sus siglas en ingl%XE9s) Cancer.gov en espa%XF1ol | Transcripci%XF3n Transmisiones de radio para promover

  11. Ensayos Mecnicos El principal objetivo del curso es el estudio de los ensayos mecnicos que permiten determinar las propiedades mecnicas

    E-print Network

    Ensayos Mecánicos El principal objetivo del curso es el estudio de los ensayos mecánicos que enfoque del curso es eminentemente práctico. Por este motivo, se dedicará un porcentaje del mismo desde el punto de vista técnico y de la ingeniería aplicada de materiales. Título del curso Resumen del

  12. Expression and Function of the Homeostatic Molecule Del-1 in Endothelial Cells and the Periodontal Tissue

    PubMed Central

    Shin, Jieun; Hosur, Kavita B.; Pyaram, Kalyani; Jotwani, Ravi; Liang, Shuang; Chavakis, Triantafyllos; Hajishengallis, George

    2013-01-01

    Developmental endothelial locus-1 (Del-1) is an endothelial cell-secreted protein that limits the recruitment of neutrophils by antagonizing the interaction between the LFA-1 integrin on neutrophils and the intercellular adhesion molecule (ICAM)-1 on endothelial cells. Mice with genetic or age-associated Del-1 deficiency exhibit increased neutrophil infiltration in the periodontium resulting in inflammatory bone loss. Here we investigated additional novel mechanisms whereby Del-1 could interfere with neutrophil recruitment and inflammation. Treatment of human endothelial cells with Del-1 did not affect the expression of endothelial molecules involved in the leukocyte adhesion cascade (ICAM-1, VCAM-1, and E-selectin). Moreover, genetic or age-associated Del-1 deficiency did not significantly alter the expression of these adhesion molecules in the murine periodontium, further ruling out altered adhesion molecule expression as a mechanism whereby Del-1 regulates leukocyte recruitment. Strikingly, Del-1 inhibited ICAM-1-dependent chemokine release (CXCL2, CCL3) by neutrophils. Therefore, Del-1 could potentially suppress the amplification of inflammatory cell recruitment mediated through chemokine release by infiltrating neutrophils. Interestingly, Del-1 was itself regulated by inflammatory stimuli, which generally exerted opposite effects on adhesion molecule expression. The reciprocal regulation between Del-1 and inflammation may contribute to optimally balance the protective and the potentially harmful effects of inflammatory cell recruitment. PMID:24416060

  13. Víctimas y victimarios: Cómplices del discurso del poder en Una noche con el Sr. Magnus e hijos de Ricardo Monti

    E-print Network

    Previdi Froelich, Roberto

    1989-10-01

    verdadera naturaleza de la dieta cotidiana de Magnus: la sutil complicidad de los demás. La caída de Magnus ahora lo convierte en "víctima" de los "victimarios" (los otros personajes) si bien ambos términos pierden su semántica a través del vínculo... of others, cheated and demeaned his fellow man in every way" ("Theatre of Dissent" 48-49). Este ensayo, que sólo dedica dos páginas a Una noche no pretende profundizar en los mecanismos ideológicos. No obstante, sufre de miopía al considerar la lucha...

  14. FERTILIZATION BY SPERM MICROINJECTION AND ZONA-DRILLING: METHODS

    EPA Science Inventory

    Successful microinjection of sperm or sperm nuclei into oocytes depends upon many factors. For example, injection needles must be large enough to pick up a sperm (nucleus) yet not so large as to kill the oocyte. The suction/pressure system should be very precisely controlled so a...

  15. Mars Reconnaissance Orbiter, Ground Data System, Receivables and Deliverables (REC/DELs)

    NASA Technical Reports Server (NTRS)

    Carlton, Magdi

    2006-01-01

    This paper presents one JPL element manager's approach to describe a complex Ground Data System (GDS) with its receivables and deliverables (REC/DEL). The Mars Reconnaissance Orbiter (MRO) Ground Data System is the integrated set of ground software, hardware, facilities and networks that support mission operation. REC/DEL is a powerful tool for specifying hierarchy of commitments among systems and teams. Receivable of a system is a deliverable of another system. Focusing on tangible products enables the manager to objectively measure progress in a schedule. Jet Propulsion Laboratory mandates the use of REC/DEL for flight projects. Tutorial and training is provided for managers to create integrated REC/DEL database using automated systems. Project schedules are based on REC/DELs. This paper is not focusing on the mechanics of REC/DEL database creation, but it provides a guideline how one systematically creates categories of deliverables and receivables for ground data system components.

  16. Mars Reconnaissance Orbiter, Ground Data System, Receivables and Deliverables (REC/DELs)

    NASA Technical Reports Server (NTRS)

    Carlton, Magdi

    2006-01-01

    This paper presents one JPL element manager's approach to describe a complex Ground Data System (GDS) with its receivables and deliverables (REC/DEL). The Mars Reconnaissance Orbiter (MRO) Ground Data System is the integrated set of ground software, hardware, facilities and networks that support mission operation. REC/DEL is a powerful tool for specifying hierarchy of commitments among systems and teams. Receivable of a system is a deliverable of another system. Focusing on tangible products enables the manager to objectively measure progress in a schedule. The Jet Propulsion Laboratory mandates the use of REC/DEL for flight projects. Tutorial and training is provided for managers to create an integrated REC/DEL database using automated systems. Project schedules are based on REC/DELs. This paper is not focusing on the mechanics of REC/DEL database creation, but it provides a guideline how one systematically creates categories of deliverables and receivables for ground data system components...

  17. 02-Oct-2006 MARTES 2006 at MoDELS 2006 1 TimeExceptions

    E-print Network

    Runde, Ragnhild Kobro

    02-Oct-2006 MARTES 2006 at MoDELS 2006 1 TimeExceptions Time Exceptions in Sequence Diagrams Oddleif Halvorsen, Ragnhild Kobro Runde, Ã?ystein Haugen #12;02-Oct-2006 MARTES 2006 at MoDELS 2006 2 Time and the exceptional parts can be refined separately #12;02-Oct-2006 MARTES 2006 at MoDELS 2006 3 TimeExceptions Time

  18. La paradoja de los 80's: Una visión particular del teatro en México

    E-print Network

    de Ita, Fernando

    1992-04-01

    Estado apoyar el desarrollo cultural de la nación, y la ha cumplido a su manera, con proyectos efímeros, interrupciones sexenales, desperdicio infame de recursos humanos y materiales, dispersión de esfuerzos, burocratización, esclerosis, jerarquización... teatro mexicano de los ochenta es la crisis del sistema político imperante desde 1929 y la del aparato cultural al que estuvo ligado el avance artístico del país. No es una crisis de talento porque en esos diez años Arguelles, Carballido, Magaña...

  19. Recontextualización poemática en La dolorosa historia del amor secreto de don José Jacinto Milanés

    E-print Network

    Febles, Jorge

    1998-04-01

    Recontextualización poemática en La dolorosa historia del amor secreto de don José Jacinto Milanês Jorge Febles Concebida casi totalmente a partir del triunfo revolucionario, la producción dramática de Abelardo Estorino se devanea entre sendas formales... subrayarlas para ubicar La dolorosa historia del amor secreto de don José Jacinto Milanês dentro de la corriente más avezada, menos aleccionadora, más problemática. A pesar de que esta pieza se escribió en 1974, no se estrenó hasta 1985, cuando el Teatro...

  20. CEMENTOS ALCALINOS El objetivo del curso es introducir a los licenciados, ingenieros, arquitectos y profesionales en el empleo de los cementos y

    E-print Network

    CEMENTOS ALCALINOS El objetivo del curso es introducir a los licenciados, ingenieros, arquitectos y curso se abordaran las bases científicas y tecnológicas que permitirían el empleo de estos materiales normativa actual. Título del curso Resumen del contenido y objeto del curso Áreas de interés del curso

  1. D.P.C.M. 17 marzo 1989 n. 117 Norme regolamentari sulla disciplina del rapporto di lavoro a tempo parziale

    E-print Network

    Di Pillo, Gianni

    D.P.C.M. 17 marzo 1989 n. 117 Norme regolamentari sulla disciplina del rapporto di lavoro a tempo di generalità l'istituto del rapporto di lavoro a tempo parziale; Visto il decreto del Presidente del impiego a tempo parziale 1. (disapplicato dall'art. 56 del C.C.N.L. - Comparto Università) 2. La

  2. Optical photometry and spectroscopy of Nova Del 2013

    NASA Astrophysics Data System (ADS)

    Tomov, T.; Ilkiewicz, K.; Swierczynski, E.; Belcheva, M.; Dimitrov, D.

    2013-08-01

    We report optical BV photometry and spectroscopy of Nova Del 2013, carried out between August 14.88 UT and August 15.08 UT. Using a 60 cm Cassegrain telescope at the Nicolaus Copernicus University Observatory (Torun, Poland) we estimated the V brightness of the Nova to be 6.31+/-0.02 mag and 6.18+/-0.03 mag on Aug. 14.94 UT and Aug. 15.02 UT respectively. HD 194113 (F2, V=8.00 mag) was used as a comparison star.

  3. Festival Report: VIII Encuentro Nacional de Teatro del CLETA

    E-print Network

    Frischmann, Donald H.

    1983-10-01

    cabalmente las preocupaciones socio-políticas de los grupos participantes, las cuales se expresaron de una manera distinta y original en las obras que cada grupo llevó a la capital jaliscience.1 A diferencia de otros festivales nacionales de teatro... organizados por varios centros oficiales de cultura, los Encuentros del CLETA no son de tipo competitivo, ni la selección de los grupos se hace con criterio de escoger sólo a los "consagrados"; es más, el hospedaje se realiza no en hoteles, sino en casas...

  4. EJERCICIO Y LA DETECCION DEL MAL AGUDO DE MONTAÑA GRAVE

    PubMed Central

    Garófoli, Adrián; Montoya, Paola; Elías, Carlos; Benzo, Roberto

    2012-01-01

    El Mal Agudo de Montaña (MAM) es un conjunto de síntomas inespecíficos padecidos por sujetos que ascienden rápidamente desde baja a alta altura sin adecuada aclimatación. Usualmente es autolimitado, pero las formas graves (edema pulmonar y cerebral) pueden causar la muerte. La hipoxemia exagerada en reposo está relacionada con el desarrollo de MAM pero su valor predictivo es limitado. Dado que el ejercicio en altura se acompaña de mayor hipoxemia y síntomas, postulamos el valor predictivo de un simple test de ejercicio para pronosticar MAM grave. Se estudió el valor predictivo de la saturación de oxígeno en reposo y ejercicio submáximo a 2 700m y 4 300m en 63 sujetos que ascendían al cerro Aconcagua (6 962m). Se consideró desaturación de oxígeno con ejercicio a una disminución >=5% respecto al reposo. Se utilizó la escala de Lake-Louise para establecer la presencia de MAM grave. 6 sujetos presentaron MAM grave (9.5%) y requirieron evacuación. La saturación de oxígeno en reposo a 2 700m no fue significativa para clasificar sujetos que luego desarrollaron MAM grave. Por el contrario, la asociación de desaturación durante el ejercicio a 2 700m más la saturación inapropiada en reposo a 4 300m fue significativa para clasificar a los sujetos que desarrollaron MAM grave con un valor predictivo positivo de 80% y un valor predictivo negativo del 97%. Nuestros resultados son relevantes para el montañismo y sugieren la adición de un simple test de ejercicio en la predicción del MAM grave. PMID:20228017

  5. Soluci'on del Examen de Teor'ia de CLII Enero 2003 Atenci'on: S'olo se entrega esta hoja del propio enunciado

    E-print Network

    Nieuwenhuis, Robert

    explicaciones. case NIdent: cod = IdentAddress(a­?texto); // carga la direccion del identificador break; case NPointsTo: cod1 = CodeGen(a­?h1); cod = ... cod1 ------ indi ; break; 1H: Idem, suponiendo que estamos compilando un sub'arbol del AST que es una right­ expression: case NLeftExpresion: cod1 = CodeGen(a­?h1); cod

  6. Estimaciones de Prevalencia del VIH por Género y Grupo de Riesgo en Tijuana, México: 2006

    PubMed Central

    Iñiguez-Stevens, Esmeralda; Brouwer, Kimberly C.; Hogg, Robert S.; Patterson, Thomas L.; Lozada, Remedios; Magis-Rodriguez, Carlos; Elder, John P.; Viani, Rolando M.; Strathdee, Steffanie A.

    2010-01-01

    OBJETIVO Estimar la prevalencia del VIH en adultos de 15-49 años de edad en Tijuana, México - en la población general y en subgrupos de riesgo en el 2006. METODOS Se obtuvieron datos demográficos del censo Mexicano del 2005, y la prevalencia del VIH se obtuvo de la literatura. Se construyó un modelo de prevalencia del VIH para la población general y de acuerdo al género. El análisis de sensibilidad consistió en estimar errores estándar del promedio-ponderado de la prevalencia del VIH y tomar derivados parciales con respecto a cada parámetro. RESULTADOS La prevalencia del VIH es 0.54%(N = 4,347) (Rango: 0.22%–0.86%, (N = 1,750–6,944)). Esto sugiere que 0.85%(Rango: 0.39%–1.31%) de los hombres y 0.22%(Rango: 0.04%–0.40%) de las mujeres podrían ser VIH-positivos. Los hombres que tienen sexo con hombres (HSH), las trabajadoras sexuales usuarias de drogas inyectables (MTS-UDI), MTS-noUDI, mujeres UDI, y los hombres UDI contribuyeron las proporciones más elevadas de personas infectadas por el VIH. CONCLUSIONES El número de adultos VIH-positivos entre subgrupos de riesgo en la población de Tijuana es considerable, marcando la necesidad de enforcar las intervenciones de prevención en sus necesidades específicas. El presente modelo estima que hasta 1 en cada 116 adultos podrían ser VIH-positivos. PMID:19685824

  7. Appunti provvisori del corso di Matematica Alessandro Berarducci e Giovanni Gaiffi 10 Dic. 2008.

    E-print Network

    Di Nasso, Mauro

    binomiali: esempi 76 7. Il triangolo di Pascal-Tartaglia 79 8. Il teorema del binomio di Newton 80 9 teorema cinese del resto 131 7. Esercizi 134 Capitolo 15. Classi di resto e anelli quoziente 141 1. Le piccolo teorema di Fermat 144 4. Esercizi 147 Capitolo 16. Gruppi e ordini 149 1. Il concetto di gruppo e

  8. El papel que desempeña el NCI en la investigación del cáncer

    Cancer.gov

    El Instituto Nacional del Cáncer (NCI) es el patrocinador más grande del mundo de investigaciones sobre el cáncer y financia investigaciones realizadas en el mismo instituto y en centros oncológicos, hospitales, clínicas comunitarias y universidades en Estados Unidos y en todo el mundo.

  9. Pierre Del Moral Date of birth: January 7th, 1965 (Nationality: French).

    E-print Network

    Del Moral , Pierre

    : http://web.maths.unsw.edu.au/peterdel-moral/ · Education : ­ Higher Degree of Research, (HPierre Del Moral Date of birth: January 7th, 1965 (Nationality: French). Married with two children Street, Kensington, SYDNEY, NSW 2052 Phone : +61 (0) 410 215 779 Emails: p.del-moral@unsw.edu.au URL

  10. Aspectos generales de la Red Nacional de Estudios Clínicos del NCI

    Cancer.gov

    Reseña general sobre la estructura organizativa de la Red Nacional de Estudios Clínicos del NCI, así como un resumen de los cambios que se están llevando a cabo y una sinopsis de cómo estos cambios se basan en el éxito del programa de Grupos Cooperativos.

  11. METODOLOGA PARA EL DISEO DE MUESTREO SOCIOAMBIENTAL EN LA CUENCA DEL RO PIEDRAS

    E-print Network

    Gilbes, Fernando

    quebradas en esta red, la variación de usos del suelo alrededor de la red y la diversidad en vegetación, suelos y condiciones geológicas. También, se buscó asegurar que los puntos de muestreo fueran, topografía, suelo, cuenca hidrográfica del Río Piedras y municipios de San Juan y Guaynabo en el sistema de

  12. DERECHOS DE LOS EMPLEADOS SEGN LA LEY NACIONAL DE RELACIONES DEL TRABAJO

    E-print Network

    DERECHOS DE LOS EMPLEADOS SEGÚN LA LEY NACIONAL DE RELACIONES DEL TRABAJO La Ley Nacional de Relaciones del Trabajo (LNRT) garantiza el derecho de los empleados a organizarse y negociar colectivamente empleadores y sindicatos. En este Aviso encontrará información general sobre sus derechos y las obligaciones

  13. Derechos de los Empleados Conforme a la Ley Nacional de Relaciones del Trabajo

    E-print Network

    Derechos de los Empleados Conforme a la Ley Nacional de Relaciones del Trabajo La Ley Nacional de Relaciones del Trabajo (National Labor Relations Act; NLRA) garantiza el derecho de los empleados empleadores y sindicatos. Este aviso le brinda información general sobre sus derechos y sobre las obligaciones

  14. MAPA DE RIESGO DE EROSIN DE SUELO PARA LA CUENCA DEL RIO YAGEZ EN PUERTO RICO

    E-print Network

    Gilbes, Fernando

    , RUSLE (por sus siglas en ingles), es comúnmente utilizada para la estimación anual de pérdida de suelos-RUSLE (por sus siglas en ingles). Objetivos del Estudio El principal objetivo del presente estudio fue utilizando el modelo de pérdida de suelos universal revisado (RUSLE) por sus siglas en ingles, para

  15. ANLISIS DE CAMBIOS EN LA CALIDAD DEL AGUA EN PUERTO RICO UTILIZANDO SISTEMAS DE INFORMACIN GEOGRFICA

    E-print Network

    Gilbes, Fernando

    ANÁLISIS DE CAMBIOS EN LA CALIDAD DEL AGUA EN PUERTO RICO UTILIZANDO SISTEMAS DE INFORMACIÓN maduros son beneficiosos para la calidad del agua en Puerto Rico. Este resultado se obtuvo integrando, mediante modelos, la información de distintas capas geográficas de Puerto Rico:(1) calidad

  16. Autorizacin para divulgar informacin mdica Nombre del paciente: ________________________________ Fecha de nacimiento: ______________

    E-print Network

    Columbia University

    siguiente información de salud protegida: Notas del consultorio /nombre del médico este formulario, autorizo el uso o la revelación de información de salud protegida como se indicó atención de salud. Puedo revocar (cancelar) esta autorización en cualquier momento antes de que revelen la

  17. Concentration for Mean Field Particle Models P. Del Moral, E. Rio

    E-print Network

    Del Moral , Pierre

    Concentration for Mean Field Particle Models P. Del Moral, E. Rio Centre INRIA de Bordeaux - Sud-INRIA RR-7019 (09). To appear in M2AN (2010) P. Del Moral, E. Rio (INRIA) INRIA Bordeaux-Sud Ouest 1 / 20 Moral, E. Rio (INRIA) INRIA Bordeaux-Sud Ouest 2 / 20 #12;Summary 1 Introduction, motivations Some

  18. UNIDAD QUERTARO La Unidad Quertaro del Cinvestav ofrece el Programa de Posgrado de Maes-

    E-print Network

    agregado. El uso del ultrasonido para determinar la dureza y calidad del grano de maíz. Caracterización Stanford, EUA. Temas de investigación: Calorimetría resistiva. Contaminación de agua por sólidos de almidón. Interacción agua- polímeros. Química y morfología a nivel atómico de heteroestructuras

  19. Caracterizacin del estado ecolgico de ros mediterrneos ibricos mediante el ndice IBMWP (antes BMWP').

    E-print Network

    Bonada, Núria

    proyecto GUADALMED (1999-2001), se estudia la calidad biológica de las aguas de 65 ríos de 12 cuencas'). Se proponen unas bases para el establecimiento de las clases de calidad para la evaluación de estado ecológico de los ríos, siguiendo las directrices de la Directiva Marco del Agua, basadas en los valores del

  20. 63. G.F.H., photographer July 30, 1932 DEL NORTE COUNTY, SECTION ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    63. G.F.H., photographer July 30, 1932 DEL NORTE COUNTY, SECTION A, HIGHWAY 1. 1-DN A #124, STA. 164=00 SHOWING DRAINAGE CONDITIONS, G.F.H., 7-30-32. - Redwood National & State Parks Roads, California coast from Crescent City to Trinidad, Crescent City, Del Norte County, CA

  1. DIRECCIN DE LA SEDE DEL LITORAL Unidad o rea Usuario(s) EXT.

    E-print Network

    Vásquez, Carlos

    DIRECCIÓN DE LA SEDE DEL LITORAL Unidad o Área Usuario(s) EXT. Asistente Dirección Lic. Ronald Directivo Sra. Daisy Alvarado 9031 Unidad de Relaciones Públicas e Información Sede del Litoral Jefatura Lic. Ysmenia Valera 9102 Asistente Administrativo Sra. Daniela Rodríguez 9101 Oficina de Inf. y Medios Lic

  2. Phytologia (August 2011) 93(2)168 JUNPERUS VIRGINIANA IN THE SERRANIAS DEL BURRO

    E-print Network

    Adams, Robert P.

    in the Rocky Mountains. Analysis of nrDNA SNPs revealed that the Colonia Pacheco juniper was more similar to JPhytologia (August 2011) 93(2)168 JUNPERUS VIRGINIANA IN THE SERRANIAS DEL BURRO MOUNTAINS in the Pleistocene. A similar Mexico population of putative J. scopulorum exists in the Serranias del Burro Mountains

  3. Parodia y desmitificación del rol femenino en el teatro femenino de Diana Raznovich

    E-print Network

    Glickman, Nora

    1994-10-01

    típica obscenidad de los medios de difusión que traiciona toda intimidad y frivoliza los hechos de orden netamente personal. Raznovich ataca además a una pornografía sutil y lamentable en mayor grado que la del espionaje sexual: la del espionaje de los...

  4. Primer registro para Peru del genero Nielsonia Young, 1977 (Hemiptera: Cicadellidae: Cicadellinae: Cicadellini)

    Technology Transfer Automated Retrieval System (TEKTRAN)

    En este articulo se reporta por primera vez para el Peru una especies del genero Nielsonia Young, 1977, de material procedente del Departamento de Tumbes. El genero ha sido reportada anteriormente de Ecuador, como unico registro para Sudamerica, y America Central. El unico especimen hembra encontra...

  5. 66. Photographer unknown March 1920'S DEL NORTE COUNTY, SECTION B, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    66. Photographer unknown March 1920'S DEL NORTE COUNTY, SECTION B, HIGHWAY 1. 1-DN 1-B #9, CORDUROY DETOUR INTO CRESCENT CITY, 2-2 (3?). Stamped office copy. - Redwood National & State Parks Roads, California coast from Crescent City to Trinidad, Crescent City, Del Norte County, CA

  6. In collaborazione con: 3,2,1...IGNITION!Il lancio del satellite Lisa Pathfinder

    E-print Network

    Moschitti, Alessandro

    IMG>©ESA In collaborazione con: 3,2,1...IGNITION!Il lancio del satellite Lisa Pathfinder e l'esplorazione dello spazio-tempo PRESENTAZIONE DELLA MISSIONE SPAZIALE LISA PATHFINDER Giovedì 26 novembre ore 18 spaziale Lisa Pathfinder e docente del Dipartimento di Fisica dell'Università di Trento Sessione Domande

  7. Independent External Peer Review Rio Grande Floodway, San Acacia to Bosque Del Apache,

    E-print Network

    US Army Corps of Engineers

    Independent External Peer Review Rio Grande Floodway, San Acacia to Bosque Del Apache, New Mexico and maintenance Office of Management and Budget Probability of Unsatisfactory Performance SADD San Acacia performed an Independent External Peer Review (IEPR) of the Rio Grande Floodway, San Acacia to Bosque Del

  8. CURSO DE INICIACIN A LA ENSEANZA DEL ESPAOL COMO LENGUA EXTRANJERA-FORMACIN DE PROFESORADO

    E-print Network

    CURSO DE INICIACIÓN A LA ENSEÑANZA DEL ESPAÑOL COMO LENGUA EXTRANJERA-FORMACIÓN DE PROFESORADO, diplomatura o grado)*: o En curso (especificar curso y carrera)*: Otros: *Será necesario acreditar los estudios en curso. FORMALIZACIÓN DE LA MATRÍCULA Para formalizar la matrícula del curso es necesario

  9. CURSO DE INICIACIN A LA ENSEANZA DEL ESPAOL COMO LENGUA EXTRANJERA-FORMACIN DE PROFESORADO

    E-print Network

    Verschure, Paul

    CURSO DE INICIACIÓN A LA ENSEÑANZA DEL ESPAÑOL COMO LENGUA EXTRANJERA-FORMACIÓN DE PROFESORADO o grado)*: En curso (especificar curso y carrera)*: Otros: *Será necesario acreditar los estudios matrícula de los estudios en curso. FORMALIZACIÓN DE LA MATRÍCULA Para formalizar la matrícula del curso es

  10. EVALUACIN DEL CURSO DE INTRODUCCIN A LA UNIVERSIDAD Moreno, Vernica 1

    E-print Network

    Bellalta, Boris

    EVALUACIÓN DEL CURSO DE INTRODUCCIÓN A LA UNIVERSIDAD (INECE'08) Moreno, Verónica 1 *, Frangi. El Curso de Introducción a la Universidad (CIU) se desarrolla en la Escuela Superior Politécnica de de las actividades realizadas en particular, así como del curso en general. Estos resultados son

  11. 33 CFR 162.200 - Marina del Rey, Calif.; restricted area.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 2 2011-07-01 2011-07-01 false Marina del Rey, Calif.; restricted area. 162.200 Section 162.200 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) PORTS AND WATERWAYS SAFETY INLAND WATERWAYS NAVIGATION REGULATIONS § 162.200 Marina del Rey, Calif.; restricted area. (a)...

  12. 33 CFR 162.200 - Marina del Rey, Calif.; restricted area.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 2 2014-07-01 2014-07-01 false Marina del Rey, Calif.; restricted area. 162.200 Section 162.200 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) PORTS AND WATERWAYS SAFETY INLAND WATERWAYS NAVIGATION REGULATIONS § 162.200 Marina del Rey, Calif.; restricted area. (a)...

  13. El cuento del cáncer de cérvix podría tener un final feliz

    Cancer.gov

    El cuento del cáncer de cérvix podría tener un final feliz Por el Instituto Nacional del Cáncer El cáncer de cérvix fue en un tiempo la causa principal de muerte por cáncer entre mujeres estadounidenses. Pero, en los últimos 50 años, el número de

  14. 60. C.J.T., photographer December 23, 1955 KLAMATH RIVER BRIDGE, DEL ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    60. C.J.T., photographer December 23, 1955 KLAMATH RIVER BRIDGE, DEL NORTE COUNTY, SECTION A, HIGHWAY 1. DN-1-A #538, KLAMATH RIVER BR. FROM SO. END, 12/23/55, C.J.T. - Redwood National & State Parks Roads, California coast from Crescent City to Trinidad, Crescent City, Del Norte County, CA

  15. UNIVERSIA ACERCA LOS CONTENIDOS DEL `MIT OPENCOURSEWARE' AL MUNDO ACADMICO HISPANO-PORTUGUS

    E-print Network

    Herr, Hugh

    gratuito y coherente a los materiales de los cursos del MIT para educadores del sector sin ánimo de lucro mayor portal universitario de habla hispano-portuguesa ha traducido los cursos de la publicación digital publicación de más de 25 cursos de MIT OpenCourseWare (MIT OCW). De este modo, los contenidos de los cursos de

  16. 1. CICLE DE CONFERNCIES al curs del Diploma d'Estudis Generals de la UPF

    E-print Network

    Verschure, Paul

    de manifest com l'antropologia, la musicologia i la literatura permeten reconstruir una conca èpica'anàlisi de la relació entre literatura i política segons s'origina a l'Índia: un recorregut a través del manifest que la tradició oriental ajuda a entendre també un dels gèneres més rics de la literatura en

  17. Violación del Principio de Equivalencia en Teorías con Dilatón de Cuerdas

    NASA Astrophysics Data System (ADS)

    Landau, S. J.; Sisterna, P. D.; Vucetich, H.

    Se estudian las violaciones al Principio de Equivalencia en Teorías con Dilatón de Cuerdas. En estos modelos, algunas de las constantes fundamentales dependen del espacio y del tiempo. Se muestra que los experimentos de caída libre no tienen aún precisión como para poner límites a los parámetros de la teoría.

  18. Spectral Characterization of Volcanic Earthquakes at Nevado del Ruiz Volcano Using

    E-print Network

    Duin, Robert P.W.

    Spectral Characterization of Volcanic Earthquakes at Nevado del Ruiz Volcano Using Spectral Band classes of volcanic earthquakes. Such an information is largely redundant; therefore, a reduce number methods in a two-class classification problem of volcanic earthquakes recorded at Nevado del Ruiz Volcano

  19. C.35delG/ GJB2 and del(GJB6-D13S1830) mutations in Croatians with prelingual non-syndromic hearing impairment

    PubMed Central

    Medica, Igor; Rudolf, Gorazd; Balaban, Manuela; Peterlin, Borut

    2005-01-01

    Background C.35delG/GJB2 mutation is the most frequent genetic cause of deafness in Caucasians. Another frequent mutation in some Caucasian populations is del(GJB6-D13S1830). Both GJB2 and GJB6 genes belong to the same DFNB1 locus and when the two mutations are found in combination in a hearing-impaired person, a digenic pattern of inheritance is suggested. Methods We examined 63 Croatian subjects (25 familial and 38 sporadic cases) with prelingual non-syndromic hearing impairment by polymerase chain reaction for the presence of the c.35delG/GJB2 and the del(GJB6-D13S1830) mutations. Results Of the 63 unrelated hearing-impaired subjects, the mutation c.35delG/GJB2 was found in 21 subjects (33.3%). In 5 of them the mutation was found in the heterozygous state, all of them being compound heterozygotes, as sequencing revealed a second mutation within the coding region of the gene in 3 subjects, and a splice site mutation in 2 subjects. The del(GJB6-D13S1830) mutation was not found in the investigated hearing-impaired Croatian subjects. Conclusion Our results contribute to the knowledge of geographic distribution and population genetics of the GJB2 and GJB6 mutations in the Europeans. PMID:16336662

  20. 1. Ttulo del proyecto "Coloquio de valoracin econmica en reas naturales protegidas en el Golfo de California"

    E-print Network

    Enríquez Andrade, Roberto Ramón

    protegidas que incluyen importantes ecosistemas de la región Los ecosistemas de la región del Golfo de ninguna otra parte del mundo. La biodiversidad y los procesos ecológicos de los ecosistemas de la región

  1. Lic. Enrique Garcini Elizondo, Comisario Suplente del Sector Educacin y Cultura DireccinDireccinDireccinDireccinDireccin

    E-print Network

    8 Lic. Enrique Garcini Elizondo, Comisario Suplente del Sector Educación y Cultura Dirección Planeación (a partir del 1o. de abril de 2001) Lic. Jorge Velasco Oliva Secretario Administrativo (hasta el

  2. 78 FR 6173 - Diana Del Grosso, Ray Smith, Joseph Hatch, Cheryl Hatch, Kathleen Kelley, Andrew Wilklund, and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-29

    ...Transportation Board [Docket No. FD 35652] Diana Del Grosso, Ray Smith, Joseph Hatch, Cheryl Hatch, Kathleen Kelley, Andrew...to a petition filed on August 1, 2012, by Diana Del Grosso, Ray Smith, Joseph Hatch, Cheryl Hatch, Kathleen Kelley,...

  3. Misión Madres Del Barrio: A Bolivarian Social Program Recognizing Housework and Creating A Caring Economy in Venezuela

    E-print Network

    Fischer-Hoffman, Cory

    2008-08-20

    ABSTRACT: This thesis began as a project about Misión Madres del Barrio; and it quickly transformed into a glimpse of the Bolivarian Revolution underway in Venezuela. Misión Madres del Barrio (MMB) is one of the pioneering social programs...

  4. Estudio del NCI revela que la obesidad extrema puede acortar la esperanza de vida hasta en 14 años

    Cancer.gov

    Los adultos con obesidad extrema tienen mayor riesgo de morir a edad más joven por cáncer y muchas otras causas entre ellas, enfermedades cardíacas, accidentes cerebrovasculares, diabetes y enfermedades del hígado y los riñones, según estudio del NCI.

  5. Assessing Glacier Hazards At Ghiacciaio Del Belvedere, Macugnaga, Italian Alps

    NASA Astrophysics Data System (ADS)

    Haeberli, W.; Chiarle, M.; Mortara, G.; Mazza, A.

    The uppermost section of the Valle Anzasca behind and above the community of Macugnaga in the Italian Alps is one of the most spectacular high-mountain land- scapes in Europe, with gigantic rock walls and numerous steep hanging glaciers. Its main glacier, Ghiacciaio del Belvedere at the foot of the huge Monte Rosa east face, is a heavily debris-covered glacier flowing on a thick sediment bed. Problems with floods, avalanches and debris flows from this ice body have been known for extended time periods. Most recently, however, the evolution of this highly dynamic environ- ment has become more dramatic. An outburst of Lago delle Locce, an ice-dammed lake at the confluenec of the tributary Ghiacciaio delle Locce with Ghiacciaio del Belvedere, caused heavy damage in 1979 and necessitated site investigation and con- struction work to be done for flood protection. The intermittent glacier growth ten- dency in the 1970es induced strong bulging of the glacier surface and, in places, caused the glacier tongue to override historical morains and to destroy newly-grown forest stands. A surge-type flow acceleration started in the lower parts of the Monte- Rosa east face during summer 2000, leading to strong crevassing and deformation of Ghiacciaio del Belvedere and extreme bulging of its orographic right margin. High water pressure and accelerated movement lasted into winter 2001/2002: the ice now started overriding the LIA moraine near Rifugio Zamboni of the CAI. In addition but rather independently, a most active detachment zone for rock falls and debris flows developed for several years now in the east face of Monte Rosa, somewhat more to the south of the accelerated glacier movement and at an altitude where relatively warm permafrost must be expected. Besides the scientific interest in these phenomena, the growing hazard potential to the local infrastructure must be considered seriously. Es- pecially potentials for the destabilization of large rock and ice masses in the east face of Monte Rosa, for interruption of the access trail to the Rifugio Zamboni by overrid- ing and/or collapse of the lateral moraine, for impacts by ice invading various instal- lations (cable car, restaurant, ski runs, trails) near the moraine hill of Belvedere, and for sudden outbursts of pressurized subglacial water or the newly formed supraglacial lake must be envisaged.

  6. Artesanos, alquimistas, mdicos y filsofos: Introduccin a los orgenes de la quimica El objetivo del curso es proporcionar una visin general del desarrollo de actividades y creencias conectadas con el origen

    E-print Network

    del curso es proporcionar una visión general del desarrollo de actividades y creencias conectadas con propias de cada época. El curso consta de dos bloques docentes. En el primero de ellos se expondrá el con la ciencia, la medicina, y su influencia en el arte y la cultura occidental Título del curso

  7. Ozone studies in the Paso del Norte region

    NASA Astrophysics Data System (ADS)

    Becerra-Davila, Fernando

    The Paso del Norte region forms the largest contiguous bi-national conglomerate on the US-Mexico border. With a combined population of around 2 million inhabitants, the Paso del Norte region is isolated, more than 500 km away from the nearest urban area of comparable size, thus making it an ideal location for air quality studies of an isolated urban environment. The meteorological conditions leading to a high ozone episode in this region, such as the historical ozone episode of June 2006, are analyzed. It is well known that stagnation and minimal winds, high temperatures, and pressure ridges over the region are conducive to high ozone episodes. In addition, the planetary boundary height is studied to understand its impact on high ozone episodes. Several studies report that ground level ozone non-attainment regulations could be caused not only by local emissions, but also by atmospheric transport. In this work the atmospheric advection of pollutants into the region is analyzed using HYSPLIT backward trajectories. Furthermore, a novel backward trajectory clustering technique is implemented for the summer of 2006. The "ozone weekend effect" (OWE) is a phenomenon by which in some geographical regions ambient ozone concentrations tend to be higher on weekends than on weekdays, despite the lower emissions of ozone precursors during those days. The observed local OWE has never previously been studied in terms of the photolysis rates of four of the main ozone precursors. In this research a novel method that allows the calculation of actinic fluxes, photolysis frequencies and photolysis rates with a high degree of accuracy and reliability has been developed. This method utilizes a combination of the experimental data available for this region in conjunction with a radiative transfer model (TUV model). Three weekend-weekday cases during summers 2006, 2009 and 2010 are studied in this work. In this research, the photolysis impact on the local OWE is studied. The results obtained from this photolysis study demonstrate that the local ground level ozone formation is not only influenced by the strong solar radiation and changing aerosol makeup, but also by other heterogeneous factors and reactions. In addition, this research provided good evidence that the ground level ozone precursor regime in El Paso during the ozone episode of June 2006 was mostly VOC-limited. Much of this estimation was derived from measurements of local ambient VOC/NOx ratios. This finding shows that at least during June 2006, the non-linear surface ozone production increased during weekends compared to workdays in a habitually VOC-limited regime. The seasonal variations of columnar ozone as measured by a Multi-filter Rotating Shadowband instrument installed at the UTEP campus are analyzed for the first time for this region and results are presented. This investigation has addressed the problem of ground-level ozone formation in the Paso del Norte region. Urban ozone is a complex problem with many aspects that are not fully understood. In this investigation, a range of techniques has been used to address the study of local surface ozone episodes with the purpose of acquiring new insights and knowledge that will help understand and remediate the diverse atmospheric pollution events that affect this bi-national region recurrently. Innovative techniques were developed and used, ranging from the use of local ambient atmospheric pollution data to the utilization of complex modeling techniques to achieve the best possible computer results. Finally, the influence of ground level ozone concentrations in admissions to hospitals for this region due to respiratory diseases is analyzed. The comprehensive results obtained in this work will help to better understand ozone formation in the Paso del Norte Region for future policy regulation implementations.

  8. Phytoseiid mites (Acari: Phytoseiidae) from Patagonia and Tierra del Fuego.

    PubMed

    Ferragut, Francisco; Navia, Denise

    2015-01-01

    Predatory phytoseiid mites have been intensively studied and surveyed in the last decades because of their economic importance as biocontrol agents of agricultural pests. However, many regions of the world remain unexplored and the diversity of the family worldwide is still fragmentary. Up to date no phytoseiid species have been collected in the southernmost part of the Earth down to latitude 45º S. In this study Phytoseiidae were sampled from native vegetation in southern Argentina and Chile in the regions of Patagonia and Tierra del Fuego Island. Thirteen species were collected, five of which were previously described and eight, Chileseius australis n. sp., Neoseiulus mapuche n. sp., Typhlodromips valdivianus n. sp., T. fissuratus n. sp., Amblyseius grandiporus n. sp., A. caliginosus n. sp., Typhlodromus (Anthoseius) anomalos n. sp. and Metaseiulus parabrevicollis n. sp. are proposed as new to science and are described and diagnosed. PMID:26250248

  9. Renewable energy load assessment for Boquillas Del Carmen Coahuila, Mexico

    SciTech Connect

    Foster, R.

    1995-08-01

    This report outlines the estimates that were made in 1992 of the potential load requirements for Boquillas del Carmen, a small Mexican village on the northern border of the state of Coahuila, Mexico near Big Bend National Park in southern Texas. The study was made to help determine the possibility that village might be electrified by solar or wind energy. Various estimates of are given of the potential load based on estimates ranging from basic use of lights, radio, television, and small household appliances to microwave ovens, refrigerators, and direct evaporative coolers. The low-energy consumption case was estimated to be at 23.0 kWh/month per residence per month, and the high-energy consumption case (with cooling) was 140.7 kWh/month per residence. On average, the typical residence is occupied by five individuals.

  10. Realizar una bandeja de Cemento para el Molde de compresin del centro de un Shape&roll pie protsico.

    E-print Network

    Chisholm, Rex L.

    Realizar una bandeja de Cemento para el Molde de compresión del centro de un Shape&roll pie the text. Superficie superior del molde (entre bordes) Bandeja de cemento. Arriba se muestra un molde de bandeja de cemento. El manual titulado "Bandeja de cemento para la parte superior del Molde de compresión

  11. A N U A R I O C I N V E S T A V838 RECURSOS DEL MAR

    E-print Network

    Mérida del Cinvestav, considerando que el estudio de los ecosistemas costeros y marinos es una de las gestión y uso racional de los ecosistemas costeros del Golfo de México y Mar Caribe, en beneficio de la ecosistemas arrecifales. Áreas marinas pro- tegidas. Indicadores ecológicos del estado de condición de

  12. http://www.iuii.ua.es/hackerclub 9. El fallo del jurado se dar a conocer antes

    E-print Network

    Escolano, Francisco

    http://www.iuii.ua.es/hackerclub 9. El fallo del jurado se dará a conocer antes del 30 de documentación: · Formulario de solicitud que se puede encontrar en la web http://www.iuii.ua.es/hackerclub junto convocatorias de junio y julio del curso 2014-2015. Dirigido a: http://www.iuii.ua.es/hackerclub http://www.iuii.ua

  13. El seminario permanente "Jueves Mnimos en la Cuesta del Chapiz" es un encuentro semanal de alta divulgacin

    E-print Network

    Fitze, Patrick

    Arquitectura de la Ciudad (LAAC)", adscrito a la Escuela de Estudios Árabes (EEA) del Consejo Superior de nombre, es la sede del Laboratorio de Arqueología y Arquitectura de la Ciudad (LAAC), adscrito a la MÍNIMOS en la Cuesta del Chapiz LABORATORIO DE ARQUEOLOGÍA Y ARQUITECTURA DE LA CIUDAD (LAAC) Carmen de

  14. EL PROTEOMA DEL TEJIDO ADIPOSO SUBCUTÁNEO MUESTRA HETEROGENEIDAD ANATÓMICA

    PubMed Central

    Martos-Moreno, G.A.; Sackmann-Sala, L.; Berryman, D.E.; Blome, D.W.; Argente, J.; Kopchick, y J.J.

    2015-01-01

    Introducción El tejido adiposo blanco (TAB) subcutáneo (Sc) humano podría variar dependiendo de su localización anatómica, con diferencias en su perfil proteómico. Pacientes y métodos Se obtuvieron aspirados de TAB-Sc de seis mujeres con IMC >25 kg/m2, sometidas a liposucción. Dicho TAB-Sc se obtuvo de seis localizaciones anatómicas: abdominal superior e inferior, muslo, dorsal, flanco y cadera, analizándose su perfil proteómico mediante electroforesis bidimensional. En muslo y abdomen superior se compararon, además, las muestras obtenidas de las dos capas del TAB-Sc (profunda y superficial). Resultados Se detectaron 21 proteínas que mostraban una intensidad de expresión diferente entre las seis localizaciones anatómicas y 14 entre las capas superficial y profunda de una misma región. Entre las proteínas identificadas se incluyen: vimentina (proteína estructural); proteínas “heat-shock” (HSPs), superóxido-dismutasa, (estrés/chaperoninas); proteína fijadora de ácidos grasos 4 (FABP-4) y alfa-enolasa (metabolismo lipídico y de los hidratos de carbono, respectivamente) y ATP-sintetasa (producción de energía). Entre las regiones estudiadas, el TAB-Sc dorsal mostraba un perfil proteómico particular, con menor expresión de proteínas implicadas en la producción de energía y metabolismo (ATP-sintetasa, alfa-enolasa, HSPs y FABP-4) que el resto de regiones. Conclusiones Los niveles de expresión de diversas proteínas en el TAB-Sc humano no son homogéneos, difiriendo entre localizaciones anatómicas. Esto sugiere la existencia de diferencias funcionales en el TAB-Sc de acuerdo con su localización anatómica, lo que debe considerarse antes de asumir la extrapolación de los datos derivados del TAB-Sc de una determinada localización al de otras partes de la anatomía. PMID:23228439

  15. RASTREO DEL CANCER COLORRECTAL CONOCIMIENTO Y ACTITUD DE LA POBLACION

    PubMed Central

    CASAL, ENRIQUE R.; VELAZQUEZ, ELIZABETH N.; MEJIA, RAUL M.; CUNEO, ALDO; PEREZ-STABLE, ELISEO J.

    2014-01-01

    Resumen El rastreo de cáncer colorrectal (CCR) cuenta con fuertes evidencias en su favor. Datos preliminares indican que a pesar de ello no se lleva a cabo con la frecuencia adecuada. Se intenta aquí determinar, dentro de un Sistema de Salud que cuenta con los recursos necesarios, los elementos que facilitan o generan barreras para concretar esta práctica preventiva, cuántos individuos lo ponen en práctica y qué predice esta conducta. Se realizó una encuesta telefónica a los afiliados de una Obra Social de empleados de la Universidad de Buenos Aires, de los que 132 completaron el cuestionario (tasa de respuesta 70%). Los elementos considerados facilitadores del rastreo obtuvieron respuestas afirmativas en el 64 a 97%, mientras que los que definían barreras un 11 a 27%. En este último grupo, una categoría diferenciada la constituía el miedo a los efectos adversos: 39%, y el sentimiento de vergüenza relacionado con los procedimientos: 30%. Un 33% de los encuestados tenían hecho un método de rastreo, mayoritariamente de sangre oculta (27), sigmoideoscopía (11) y colonoscopía (20). Una mayoría afirmó que “se haría el procedimiento si el médico se lo recomendara” (95%), o “no se lo haría excepto que su médico se lo aconseje” (87%). Contestar afirmativamente que “los médicos hacen lo mejor para los pacientes” se asoció con haberse hecho un método de rastreo de CCR, OR 1.55 (IC 95%: 1.02-2.37) p: 0.04. El grupo de individuos estudiado parece bien predispuesto para el rastreo del CCR, la recomendación médica sería aquí un determinante prominente para ponerlo en práctica. PMID:19414294

  16. DEL-1 restrains osteoclastogenesis and inhibits inflammatory bone loss in nonhuman primates.

    PubMed

    Shin, Jieun; Maekawa, Tomoki; Abe, Toshiharu; Hajishengallis, Evlambia; Hosur, Kavita; Pyaram, Kalyani; Mitroulis, Ioannis; Chavakis, Triantafyllos; Hajishengallis, George

    2015-09-30

    DEL-1 (developmental endothelial locus-1) is an endothelial cell-secreted protein that regulates LFA-1 (lymphocyte function-associated antigen-1) integrin-dependent leukocyte recruitment and inflammation in various tissues. We identified a novel regulatory mechanism of DEL-1 in osteoclast biology. Specifically, we showed that DEL-1 is expressed by human and mouse osteoclasts and regulates their differentiation and resorptive function. Mechanistically, DEL-1 inhibited the expression of NFATc1, a master regulator of osteoclastogenesis, in a Mac-1 integrin-dependent manner. In vivo mechanistic analysis has dissociated the anti-inflammatory from the anti-bone-resorptive action of DEL-1 and identified structural components thereof mediating these distinct functions. Locally administered human DEL-1 blocked inflammatory periodontal bone loss in nonhuman primates-a relevant model of human periodontitis. The ability of DEL-1 to regulate both upstream (inflammatory cell recruitment) and downstream (osteoclastogenesis) events that lead to inflammatory bone loss paves the way to a new class of endogenous therapeutics for treating periodontitis and perhaps other inflammatory disorders. PMID:26424570

  17. High-content functional screen to identify proteins that correct F508del-CFTR function.

    PubMed

    Trzcinska-Daneluti, Agata M; Ly, Diane; Huynh, Lise; Jiang, Chong; Fladd, Christopher; Rotin, Daniela

    2009-04-01

    Cystic Fibrosis is caused by mutations in CFTR, with a deletion of a phenylalanine at position 508 (F508del-CFTR) representing the most common mutation. The F508del-CFTR protein exhibits a trafficking defect and is retained in the endoplasmic reticulum. Here we describe the development of a high-content screen based on a functional assay to identify proteins that correct the F508del-CFTR defect. Using a HEK293 MSR GripTite cell line that stably expresses F508del-CFTR, we individually co-expressed approximately 450 unique proteins fused to the Cl(-)-sensitive YFP(H148Q/I152L) mutant. We then tested correction of F508del-CFTR function by the CI(-)/l(-) exchange method following stimulation with forskolin/IBMX/genistein, using quantitative recordings in multiple individual cells with a high-content (high-throughput) Cellomics KSR imaging system. Using this approach, we identified several known and novel proteins that corrected F508del-CFTR function, including STAT1, Endothelin 1, HspA4, SAPK substrate protein 1, AP2M1, LGALS3/galectin-3, Trk-fused gene, Caveolin 2, PAP/REG3alpha, and others. The ability of these correctors to rescue F508del-CFTR trafficking was then validated by demonstrating their enhancement of maturation (appearance of band C) and by cell surface expression of F508del-CFTR bearing HA tag at the ectodomain using confocal microscopy and flow cytometry. These data demonstrate the utility of high-content analyses for identifying proteins that correct mutant CFTR and discover new proteins that stimulate this correction. This assay can also be utilized for RNAi screens to identify inhibitory proteins that block correction of F508del-CFTR, small molecule, and peptide screens. PMID:19088066

  18. Resultados del relevamiento de HI en el Cielo Austral: 3. Relevamiento de Nubes de Alta Velocidad

    NASA Astrophysics Data System (ADS)

    Morras, R.; Bajaja, E.; Arnal, E. M.; Pöppel, W. G. L.

    Los resultados del relevamiento de HI del Hemisferio Austral fueron reprocesados con el fin de incrementar su sensibilidad. Así, se utilizó esta nueva base de datos con el fin de obtener un nuevo relevamiento de Nubes de Alta Velocidad en el cielo austral. El ruido r.m.s. alcanzado es de 0.015-0.020 K, con una resolución espectral de 8 km/seg. El cubrimiento espacial del relevamiento mejora en un factor 16 al realizado por Bajaja et al (1985).

  19. Spatial shell structure of the novas DQ Her and HR Del

    SciTech Connect

    Pilyogin, L.S.

    1986-03-01

    This paper considers the formation of the spatial shell structure of the novas DQ Her (1934) and HR Del (1967). It is shown that the existence of polar caps is due to the influence of the second component of the system on the angular distribution of the mass shell depth of the mainshell. The ratio of the mass shell depth in the equatorial ring and in the polar caps is 1.13 for DQ Her and 2.7 for HR Del. The ratio of the maximal densities in the equatorial ring and the polar caps is of order 3 for DQ Her and of order 70 for HR Del.

  20. La actividad teatral en Guatemala en la primera mitad del siglo XX

    E-print Network

    Ferná ndez Molina, Manuel

    1996-04-01

    actividad teatral en Guatemala en la primera mitad del siglo XX Manuel Fernández Molina En las páginas siguientes se ofrece un panorama del desarrollo teatral en Guatemala desde 1900 hasta los últimos anos de la década de 1950. Es un intento de dar... siete partes en las que se señala lo más destacado del período. 1. La actividad teatral centrada en el Teatro Colón En este apartado se traza un esbozo de la actividad escénica en Guatemala con anterioridad a que surgiera algún grupo nacional estable...

  1. Exploración del Sistema Solar -- Una mirada hacia el futuro - Duration: 30 seconds.

    NASA Video Gallery

    ¿Piensas que ya sabemos todo acerca de nuestro sistema solar? La realidad es que apenas hemos comenzado con lo que hay para conocer. Únete a la NASA, en el envío de misiones a los confines del sist...

  2. DeaLing with Ontologies using CODs Chiara Del Vescovo1

    E-print Network

    Baader, Franz

    DeaLing with Ontologies using CODs Chiara Del Vescovo1 and Rafael Pe~naloza2 1 School of Computer the Context-Oriented Decomposition (COD) of an ontology as a technique that combines the benefits of both

  3. Qué es la medicina de precisión en el tratamiento del cáncer

    Cancer.gov

    Información sobre el papel que tiene la medicina de precisión en el tratamiento del cáncer. Incluye cómo se identifican los cambios genéticos en el cáncer de una persona y pueden usarse para seleccionar tratamientos con más probabilidad de ayudarle.

  4. "LAUDATIO" PRONUNCIATA IN OCCASIONE DEL CONFERIMENTO DELLA LAUREA AD HONOREM A RUDOLF B. SCHLESINGER.

    E-print Network

    Moschitti, Alessandro

    energie. È un compito che mi accingo a svolgere con grande piacere e con un pizzico di orgoglio essendo stato di Schlesinger studente prima e poi successore ad Hastings. La sola lettura del curriculum vitae e

  5. Las Escrituras del Margen. En Torno a los Territorios Canónicos de la Literatura Latinoamericana 

    E-print Network

    Ayarza-Riveros, Luis Carlos

    2013-12-09

    Las Escrituras del Margen: En torno a los territorios canónicos de la literature contemporánea Latinoamericana. Lorenzo García Vega, Jorge Gaitán Durán, and Nicolás Gómez Dávila, is the study of some ...

  6. BOLETN OFICIAL DEL ESTADO Nm. 269 Martes 10 de noviembre de 2015 Sec. III. Pg. 106459

    E-print Network

    Escolano, Francisco

    BOLETÍN OFICIAL DEL ESTADO Núm. 269 Martes 10 de noviembre de 2015 Sec. III. Pág. 106459 ANEXO II ESTADO Núm. 269 Martes 10 de noviembre de 2015 Sec. III. Pág. 106460 Estado Nivel y modalidad Titulación

  7. Curso online del 6 al 22 de julio de 2015 2 crditos ECTS* Precio: 60 euros.

    E-print Network

    Escolano, Francisco

    Curso online del 6 al 22 de julio de 2015 ­ 2 créditos ECTS mediante entrega de ejercicios con Photoshop. Para realizar el curso es a extinguir. Curso organizado por el Departamento de Física, Ingeniería

  8. Exploración del Nuevo Laboratorio Científico de Marte - Duration: 2 minutes, 51 seconds.

    NASA Video Gallery

    Únase a Fernando Abilleira, un analista de trayectoria de la NASA para la Oficina de Exploración de Marte, y conozca las nuevas tecnologías que el nuevo robot Curiosity del Laboratorio Científico d...

  9. Stochastic particle models and methods in risk analysis P. Del Moral (INRIA research team ALEA)

    E-print Network

    Del Moral , Pierre

    efficiency, food risk analysis, bacterial propagations. System reliability : production chains, offshoreStochastic particle models and methods in risk analysis P. Del Moral (INRIA research team ALEA Watermarking & Digital fingerprinting Fiber optics communication Food risk & Epidemic propagations Performance

  10. Uso del punto de transicion en la seleccion de terminos indice para agrupamiento de textos cortos

    E-print Network

    Rosso, Paolo

    pertenecen al mismo domino. En caso de que el dominio sea desconocido, pueden em- plearse t´ecnicas de Sociedad Española para el Procesamiento del Lenguaje Natural #12;(Salton y Buckley, 1988); esto es, el peso

  11. Análisis Molecular para Selección de Tratamientos (NCI-MATCH), estudio del NCI

    Cancer.gov

    Información sobre el estudio del NCI: Análisis Molecular para Selección de Tratamientos (NCI-MATCH), en el cual los investigadores examinarán tejidos de tumor de pacientes con tumores sólidos y linfomas avanzados que han dejado de responder al tratamiento.

  12. ``Campo del Cielo'' Meteorites: Astronomical Heritage and Cultural Colonialism

    NASA Astrophysics Data System (ADS)

    López, Alejandro Martín; Altman, Agustina

    2012-09-01

    In the province of Chaco, Argentina, there is a very unique dispersion of metallic meteorites called ``Campo del Cielo''. One of the meteoric fragments of this dispersion, the meteorite called ``El Chaco'', consisting of 37 tons, is the second heaviest in the world. These meteorites are of great importance to the worldview of the Moqoit, aboriginal people that inhabit this region. For the local Creole population the meteorites are also relevant, that's why they have being cited in numerous documents and reports since the colonial period. During the first months of 2012, two Argentine artists and the Artistic Director of the German contemporary art exhibition called dOCUMENTA (13) tried to move ``El Chaco'' meteorite to Germany in order to exhibit it as an artistic object. Due to the fact that moving the meteorite could have a negative impact according to the Moqoit cosmology and that they were not able to participate in the decision they begun a manifestation against the movement of El Chaco. The opposition made by aboriginal communities and experts in cultural astronomy was able to stop the transfer. The whole process and its impact on the local community have promoted a deep discussion about art, science and cultural colonialism. In this paper we aim to address this debate and its consequences. This will allow us to think about contemporary forms of colonialism that are hidden in many scientific and artistic projects. Furthermore, we aim to debate about the most effective ways of protecting astronomical heritage in the Third World.

  13. Se inicia estudio de los NIH sobre respuestas excepcionales al tratamiento del cáncer

    Cancer.gov

    La Iniciativa de Respuestas Excepcionales (Exceptional Responders Initiative), un estudio que investiga los factores moleculares de los tumores en pacientes de cáncer que responden en forma excepcional al tratamiento con medicamentos, se inició hoy bajo la guía del Instituto Nacional del Cáncer (NCI). Los científicos tratarán de identificar en los tumores las características moleculares que predicen si un medicamento o una clase de medicamento en particular será beneficioso o no.

  14. ? DNMT3B4-del Contributes to Aberrant DNA Methylation Patterns in Lung Tumorigenesis

    PubMed Central

    Ma, Mark Z.; Lin, Ruxian; Carrillo, José; Bhutani, Manisha; Pathak, Ashutosh; Ren, Hening; Li, Yaokun; Song, Jiuzhou; Mao, Li

    2015-01-01

    Aberrant DNA methylation is a hallmark of cancer but mechanisms contributing to the abnormality remain elusive. We have previously shown that ?DNMT3B is the predominantly expressed form of DNMT3B. In this study, we found that most of the lung cancer cell lines tested predominantly expressed DNMT3B isoforms without exons 21, 22 or both 21 and 22 (a region corresponding to the enzymatic domain of DNMT3B) termed DNMT3B/?DNMT3B-del. In normal bronchial epithelial cells, DNMT3B/?DNMT3B and DNMT3B/?DNMT3B-del displayed equal levels of expression. In contrast, in patients with non-small cell lung cancer NSCLC), 111 (93%) of the 119 tumors predominantly expressed DNMT3B/?DNMT3B-del, including 47 (39%) tumors with no detectable DNMT3B/?DNMT3B. Using a transgenic mouse model, we further demonstrated the biological impact of ?DNMT3B4-del, the ?DNMT3B-del isoform most abundantly expressed in NSCLC, in global DNA methylation patterns and lung tumorigenesis. Expression of ?DNMT3B4-del in the mouse lungs resulted in an increased global DNA hypomethylation, focal DNA hypermethylation, epithelial hyperplastia and tumor formation when challenged with a tobacco carcinogen. Our results demonstrate ?DNMT3B4-del as a critical factor in developing aberrant DNA methylation patterns during lung tumorigenesis and suggest that ?DNMT3B4-del may be a target for lung cancer prevention. PMID:26629529

  15. Variaciones del grupo base de la Medida de Mahler Oliver T. Dasbach, Matilde N. Lalin*

    E-print Network

    Lalín, Matilde

    Variaciones del grupo base de la Medida de Mahler Oliver T. Dasbach, Matilde N. Lal´in* *UBC´umeros Julio 17, 2007 Oliver T. Dasbach, Matilde N. Lal´in* (UBS-PIMS, MPIM, U of A)Variaciones del grupo base Jensen, m a (x - i ) = log |a| + log max{1, |i |}. Oliver T. Dasbach, Matilde N. Lal´in* (UBS-PIMS, MPIM

  16. Curso de Especializacin del CSIC Fecha: 23-26 de noviembre 2015

    E-print Network

    Curso de Especialización del CSIC Fecha: 23-26 de noviembre 2015 Organización: Carolina Simó y Virginia García Cañas #12;Descripción del curso Se trata de un curso de introducción a las técnicas �micas como la evaluación de su actividad biológica in-vitro. El curso está dirigido a licenciados

  17. Targeting F508del-CFTR to develop rational new therapies for cystic fibrosis

    PubMed Central

    Cai, Zhi-wei; Liu, Jia; Li, Hong-yu; Sheppard, David N

    2011-01-01

    The mutation F508del is the commonest cause of the genetic disease cystic fibrosis (CF). CF disrupts the function of many organs in the body, most notably the lungs, by perturbing salt and water transport across epithelial surfaces. F508del causes harm in two principal ways. First, the mutation prevents delivery of the cystic fibrosis transmembrane conductance regulator (CFTR) to its correct cellular location, the apical (lumen-facing) membrane of epithelial cells. Second, F508del perturbs the Cl? channel function of CFTR by disrupting channel gating. Here, we discuss the development of rational new therapies for CF that target F508del-CFTR. We highlight how structural studies provide new insight into the role of F508 in the regulation of channel gating by cycles of ATP binding and hydrolysis. We emphasize the use of high-throughput screening to identify lead compounds for therapy development. These compounds include CFTR correctors that restore the expression of F508del-CFTR at the apical membrane of epithelial cells and CFTR potentiators that rescue the F508del-CFTR gating defect. Initial results from clinical trials of CFTR correctors and potentiators augur well for the development of small molecule therapies that target the root cause of CF: mutations in CFTR. PMID:21642944

  18. [Molecular mechanism of RhDel phenotype in blood donation population of Chinese Harbin area].

    PubMed

    Li, Ji-Hong; Zhang, Chun-Yan; Sun, Jian-Hua; Liu, Jie

    2012-12-01

    This study was aimed to explore the molecular mechanism of RhDel phenotype expression in blood donors of Chinese Harbin area. Three hundred and seventy-four RhD negative donors confirmed by indirect antiglobulin test were detected by using serological and molecular methods for red blood cell RhD blood group genotyping and RH gene variant detection. And the other special samples of undetermined RhD genotype were sequenced. The results showed that 62 cases of Del type were detected in 374 negative blood donors' samples, accounting for 16.6%, among them there were 61 cases of RHD1227A, and 1 case of rare RHD Del (cde) 1 allele was found. Sequencing analysis indicated that RHD711DelC allele existed in 11 cases. In addition, the new mutant alleles were found in 3 samples. It is concluded that RHD1227A allele is generally carried allele in Del phenotype population of Chinese Harbin area and is an important genetic marker in Del phenotype individual. PMID:23257457

  19. Mini-mastoidectomía para anastomosis hipogloso-facial con sección parcial del nervio hipogloso

    PubMed Central

    Campero, Álvaro; Ajler, Pablo; Socolovsky, Mariano; Martins, Carolina; Rhoton, Albert

    2012-01-01

    Introducción: La anastomosis hipogloso-facial es la técnica de elección para la reparación de la parálisis facial cuando no se dispone de un cabo proximal sano del nervio facial. La técnica de anastomosis mediante fresado mastoideo y sección parcial del hipogloso minimiza la atrofia lingual sin sacrificar resultados a nivel facial. Método: La porción mastoidea del nervio facial transcurre por la pared anterior de la AM, a un promedio de 18+/-3 mm de profundidad respecto de la pared lateral. Se debe reconocer la cresta supramastoidea, desde la cual se marca una línea vertical paralela al eje mayor de la AM, 1 cm por detrás de la pared posterior del CAE El fresado se comienza desde la línea medio mastoidea hasta la pared posterior del CAE. Una vez encontrado el nervio facial en el tercio medio del canal mastoideo, el mismo es seguido hacia proximal y distal. Resultados: El abordaje descripto permite acceder al nervio facial intratemporal en su porción mastoidea, y efectuar un fresado óseo sin poner en riesgo al nervio o a estructuras vasculares cercanas. Se trata de un procedimiento técnicamente más sencillo que los abordajes amplios habitualmente utilizados al hueso temporal; no obstante su uso debe ser restringido mayormente a la anastomosis hipogloso-facial. Conclusión: Esta es una técnica relativamente sencilla, que puede ser reproducida por cirujanos sin mayor experiencia en el tema, luego de su paso por el laboratorio de anatomía. PMID:23596555

  20. Tratamiento Quirúrgico de los Meningiomas del Foramen Óptico, Técnicay Resultados de una Serie de 18 Pacientes

    PubMed Central

    Goldschmidt, Ezequiel; Ajler, Pablo; Campero, Álvaro; Landriel, Federico; Sposito, Maximiliano; Carrizo, Antonio

    2014-01-01

    Introducción: los meningiomas del foramen óptico producen un rápido deterioro de la función visual aún cuando su tamaño es pequeño, por eso su diagnóstico y manejo difiere del resto de los meningiomas clinoideos. El propósito de este estudio es presentar la técnica y los resultados de nuestro manejo quirúrgico de meningiomas foraminales (MF). Pacientes y Métodos: se llevó a cabo una revisión de las historias clínicas de 47 pacientes con meningiomas primarios intraorbitarios. Se realizaron 52 cirugías en los pacientes con MF. Se empleó una craneotomía fronto-orbitaria, seguida de una descompresión extradural del canal óptico, resección del componente intraorbitario y exploración intradural del nervio óptico. Resultados: de los 12 pacientes con MF que presentaban la visión conservada, la agudeza visual fue preservada en 7 casos, mejoró en 2, y empeoró en 3. En 18 pacientes, el principal síntoma fue exoftalmos y en 35 pacientes ceguera unilateral. Ocurrieron 6 recurrencias, 2 a 10 años después de la resección quirúrgica. Cinco de ellos fueron reoperados. Se indicó radioterapia después de la recurrencia en 3 pacientes. Conclusión: el manejo de los MF continúa siendo controvertido y frecuentemente se propone un tratamiento conservador. Basados en nuestros hallazgos de frecuente extensión intracraneal, proponemos realizar una resección total o subtotal del tumor, preservando el nervio óptico en pacientes con visión prequirúrgica conservada. PMID:25165616

  1. Evaluación de la utilidad diagnóstica de la versión española del cuestionario al informador «AD8»?

    PubMed Central

    Pardo, C. Carnero; de la Vega Cotarelo, R.; Alcalde, S. López; Aparicio, C. Martos; Carrillo, R. Vílchez; Gavilán, E. Mora; Galvin, J.E.

    2012-01-01

    Introducción El AD8 es un cuestionario al informador breve que puede ser autoaplicado y facilita la identificación de deterioro cognitivo (DC); nuestro objetivo es evaluar la utilidad diagnóstica (UD) de una versión española. Material y métodos Estudio transversal en una muestra clínica de díadas paciente/ informador, 330 sujetos con sospecha de DC o demencia (DEM) y 71 controles. Se ha evaluado la consistencia interna (? de Cronbach) y la validez (correlaciones parciales con estadio GDS, Fototest e índice funcional [IF]). La UD se ha evaluado para no DC vs DC (GDS 3–4) por medio del área bajo la curva ROC (aROC) y se ha considerado mejor punto de corte aquel que hacía máximo el índice de Youden. Resultados En la muestra, 105 no tenían DC, 99 tenían DC sin DEM y 203 DEM. La consistencia interna es alta (? 0,90, IC del 95%, 0,89–0,92), al igual que las correlaciones con GDS (r = 0,72, p < 0,001), Fototest (r = ?0,61, p < 0,001) e IF (r = 0,59, p < 0,001). El aROC del AD8 es 0,90 (IC del 95%, 0,86–0,93), sin diferencia significativa con la del Fototest (aROC 0,93, IC del 95%, 0,89–0,96); el mejor punto de corte es 3/4 con sensibilidad de 0,93 (IC del 95%, 0,88–0,96), especificidad de 0,81 (IC del 95%, 0,72–0,88) y el 88,8% de las clasificaciones correctas. El uso conjunto de AD8 y Fototest mejora de forma significativa la UD de ambos (aROC 0,96, IC del 95%, 0,93–0,98, p < 0,05). Conclusiones La versión española del AD8 conserva las cualidades psicométricas y la UD de la versión original; su uso combinado con el Fototest mejora de forma significativa la UD de ambos. PMID:22652137

  2. Verbale della Riunione del Collegio dei Docenti del Corso di Dottorato di Ricerca cicli XXIX e XXX, in data 4 dicembre 2014

    E-print Network

    Pettenella, Davide

    XXIX e XXX, in data 4 dicembre 2014 L'anno 2014 il giorno 4 dicembre, alle ore 13:30, presso il programma di collaborazione del China Scolarship Council; 7) Rappresentanti dei Dottorandi cicli XXIX e XXX XXX ciclo. Si raccomanda di arrivare alla nomina con la scelta di uno dei due nominativi non

  3. AUTORIZACIN PARA LA REVELACIN DE LA INFORMACIN DE SALUD CONFORME CON LA LEY HIPAA Nombre del paciente Fecha de nacimiento Numero del Expediente

    E-print Network

    Columbia University

    AUTORIZACIÓN PARA LA REVELACIÓN DE LA INFORMACIÓN DE SALUD CONFORME CON LA LEY HIPAA Nombre del, solicito(a) que la información de salud con respect a mi cuidado y tratamiento se revele según se establece relacionada con el USO EXCESIVO DE ALCOHOL Y CONSUMO DE DROGRAS, TRATAMIENTO PARA LA SALUD MENTAL, except las

  4. Screening for F508del as a first step in the molecular diagnosis of cystic fibrosis*,**

    PubMed Central

    Marson, Fernando Augusto de Lima; Bertuzzo, Carmen Silvia; Ribeiro, Maria Ângela Gonçalves de Oliveira; Ribeiro, Antônio Fernando; Ribeiro, José Dirceu

    2013-01-01

    OBJECTIVE: To determine the relevance of screening for the F508del mutation of the cystic fibrosis transmembrane conductance regulator gene as a first step in the genetic diagnosis of cystic fibrosis (CF) by associating the genotype with various clinical variables. METHODS: We evaluated 180 CF patients regarding the F508del mutation. The clinical data were obtained from the medical records of the patients and from interviews with their parents or legal guardians. RESULTS: Of the 180 patients studied, 65 (36.1%) did not carry the F508del mutation (group 0 [G0]), 67 (37.2%) were F508del heterozygous (G1), and 48 (26.7%) were F508del homozygous (G2). All three groups showed associations with the clinical variables. Homozygosis was associated with younger patients, younger age at CF diagnosis, and younger age at the first isolation of Pseudomonas aeruginosa (PA), as well as with higher prevalence of pancreatic insufficiency (PI) and non-mucoid PA (NMPA) colonization. In comparison with G1+G2 patients, G0 patients were older; first experienced clinical symptoms, digestive disease, and pulmonary disease at an older age; were older at CF diagnosis and at first PA isolation; and had a lower prevalence of PI and meconium ileus, as well as of colonization by NMPA, mucoid PA, and Burkholderia cepacia. In G1 patients, values were intermediate for age at CF diagnosis; age at first PA isolation, first pulmonary symptoms, and first clinical manifestations; MPA colonization; and OR for PI. CONCLUSIONS: The identification of F508del in 63.9% of the patients studied showed that this can be a useful tool as a first step in the genetic diagnosis of CF. The F508del genotype was associated with clinical severity of the disease, especially with the variables related to CF onset. PMID:23857699

  5. [Radiological percutaneous gastrostomy (grp), 17 años de experiencia, serie de casos del hospital universitario virgen del rocío].

    PubMed

    Navarro Falcón, Magnolia Del Carmen; Parejo Campos, Juana; Pereira Cunill, José Luis; García Luna, Pedro Pablo

    2015-01-01

    When assessing a patient nutritional support the state of the gastrointestinal tract is the most important point to consider, whenever possible we should choose the enteral nutrition (EN) over parenteral nutrition (PN) and recognized by its various advantages. The percutaneous gastrostomy (GRP) were introduced in clinical practice as an alternative to surgical gastrostomy (GQ). The speed, simplicity, low cost, low morbidity and low mortality of these techniques has allowed its rapid development.The feeding tubes types used were the balloon-retained devices catheter, the pig tail and the ballon-retained with gastropexia (gastropexia). It is a retrospective study of all patients who were placed GPR in the Virgen del Rocío University Hospital, Sevilla, between September 1996 and September 2013, which aims to study is to describe the characteristics of patients and the complications presented for different types of enteral feeding tubes used. GPR 186 were performed in 176 patients (135 males (76.70%), with an average duration of 303.6 days, the most frequent diseases were cancers of the head and neck 49.46%. The types of feeding tubes used were pigtail 118 (63.44%), balloon-retained devices 22 (11.83%), and gastropexia 46 (24.73%). The most common early complications in the pigtail group were early purulent exudate and early bleeding (2.5 and 3.4% respectively), while in the balloon catheter group the initial output of the probe was most frequent early complication (13.7%), none of these complications were observed in the group of gastropexy. The most common late complication was obstruction probe. The GPR is a safe technique with lower mortality of 1%; Low frequently of early and late complications. A better understanding of this technique can reduce the frequency of complications. PMID:25561125

  6. High mountain soils and periglacial features at the Torres del Paine, National Park Torres del Paine, Chile.

    NASA Astrophysics Data System (ADS)

    Senra, Eduardo; Schaefer, Carlos; Simas, Felipe; Gjorup, Davi

    2015-04-01

    The Torres del Paine National Park (TPNP) is located on the southern limit of the Andean Southern Ice Field, part of the Magallanes and Antartica Chilena region, in the province of Ultima Esperanza. The TPNP has a very heterogeneous climate due to orographic influence and wet air masses from the Pacific. The geology is basically Cretaceous metasedimentary rocks and Miocene granitic plutons and batholiths. We studied the main soils and geoenvironments of Mt Ferrier mountain and its surroundings, based on soils , landforms and vegetation aspects. The geoenvironmental stratification was based on the combined variation and integration of pedo-litho-geomorphological features with the vegetation. WE used detailed geological maps, a DEM and slope maps and WorlView II satellite images. Fifteen soils profiles were sampled and classified according to Soil Taxonomy (2010) at all genovironments, ranging from 50 m a.s.l to the at high plateau just below the permanent snowline, under periglacial conditions (~1004m asl). Three soil temperature and moisture monitoring sites were set, allowing for 24 consecutive months (2011 to 2013). Seven geoenvironments were identified with distinct soil and landform characteristics, all with a similar geological substrate. The landform and vegetation have a strong connection with the landscape dynamic, controlling erosional and depositional processes, resulting from glacier advances and retreats in the Late Quaternary. Wind blown materials is widespread, in the form of loess material, accumulating in the higher parts of the landscape. On the other hand, accumulation of organic matter in the water-saturated depressions is common in all altitudes. Generally the soils are acidic and dystrophic, with little exceptions. The following geoenvironments were identified: Periglacial Tundra, Loess slopes, Talus and scarpmentd, Fluvio-glacial terraces, Fluvio-lacustrine plains, Moraines and Paleodunes. The regional pedology show the occurrence of five soil orders (Soil Taxonomy, 2010): Histosols, Mollisols, Inceptsols, Entisols and Andisols.

  7. CONTAMINACIÓN AMBIENTAL, VARIABILIDAD CLIMÁTICA Y CAMBIO CLIMÁTICO: UNA REVISIÓN DEL IMPACTO EN LA SALUD DE LA POBLACIÓN PERUANA

    PubMed Central

    Gonzales, Gustavo F.; Zevallos, Alisson; Gonzales-Castañeda, Cynthia; Nuñez, Denisse; Gastañaga, Carmen; Cabezas, César; Naeher, Luke; Levy, Karen; Steenland, Kyle

    2015-01-01

    RESUMEN El presente artículo es una revisión sobre la contaminación del agua, el aire y el efecto del cambio climático en la salud de la población peruana. Uno de los principales contaminantes del aire es el material particulado menor de 2,5 ? (PM 2,5), en la ciudad de Lima, anualmente 2300 muertes prematuras son atribuibles a este contaminante. Otro problema es la contaminación del aire domiciliario por el uso de cocinas con combustible de biomasa, donde la exposición excesiva a PM 2,5 dentro de las casas es responsable de aproximadamente 3000 muertes prematuras anuales entre adultos, con otro número desconocido de muertes entre niños debido a infecciones respiratorias. La contaminación del agua tiene como principales causas los desagües vertidos directamente a los ríos, minerales (arsénico) de varias fuentes, y fallas de las plantas de tratamiento. En el Perú, el cambio climático puede impactar en la frecuencia y severidad del fenómeno de El Niño oscilación del sur (ENSO) que se ha asociado con un incremento en los casos de enfermedades como cólera, malaria y dengue. El cambio climático incrementa la temperatura y puede extender las áreas afectadas por enfermedades transmitidas por vectores, además de tener efecto en la disponibilidad del agua y en la contaminación del aire. En conclusión, el Perú, pasa por una transición de factores de riesgo ambientales, donde coexisten riesgos tradicionales y modernos, y persisten los problemas infecciosos y crónicos, algunos de los cuales se asocian con problemas de contaminación de agua y de aire. PMID:25418656

  8. Objetivo: la proteccin de las gorgonias en Tabarca. Un centro

    E-print Network

    Escolano, Francisco

    marinosnecesitanaguasfríasyles estáafectandoelcalor;porejem- plo, el verano pasado el agua del mar estuvo en grados cuando lo va destinada a pro- gramas de desarrollo y mejora de la calidad de vida en zonas empobre- cidas

  9. Accidentes en plantas nucleares de electricidad y el riesgo de cáncer

    Cancer.gov

    Hoja informativa acerca de los riesgos del cáncer asociados con accidentes en plantas nucleares de electricidad. Incluye información para pacientes con cáncer que viven en una zona que puede haber sido afectada por un accidente en una planta nuclear.

  10. La implantacion del enfoque constructivista en el aula de ciencia: Estudio de caso multiple

    NASA Astrophysics Data System (ADS)

    Arroyo Betancourt, Luz I.

    Esta investigacion estudia la implantacion del enfoque constructivista en tres aulas de ciencia del contexto puertorriqueno. Se auscultaron las practicas educativas que utilizan maestras consideradas constructivistas y la correspondencia de sus practicas educativas con los elementos esenciales de la didactica que proponen los teoricos de los planteamientos constructivistas. Se ausculto, ademas, a que vision del enfoque constructivista responden las expresiones de las maestras acerca de su practica educativa y como compara con su quehacer, a la luz de los elementos esenciales de las visiones constructivistas piagetiana, social y radical. Se utilizo el diseno de estudio descriptivo de caso multiple. El estudio se baso en entrevistas a profundidad, revision de documentos y observacion no participativa a la sala de clases. El contexto fueron tres escuelas publicas de la Region Educativa de San Juan, una elemental, una intermedia y una superior. Los resultados confirmaron que la transicion hacia el enfoque constructivista es un proceso que toma tiempo, dedicacion y la participacion en adiestramientos y readiestramientos acerca del nuevo enfoque. Las maestras coinciden en la mayoria de las practicas educativas que utilizan para implantar el enfoque constructivista de ensenanza y difieren en algunas debido, probablemente, a que han tenido que adaptarlas a los correspondientes niveles de ensenanza: elemental, intermedio y superior. Dos de las maestras planifican por conceptos generadores, mientras que una de ellas planifica siguiendo la guia que recibe del Departamento de Educacion. Difieren ademas, en el enfasis que confieren al inquirir cientifico. Con relacion a la correspondencia entre la vision manifestada por las maestras a la luz de las visiones piagetiana, social y radical, aparentemente, las preguntas del protocolo de entrevistas no lograron evocar la informacion con suficiente profundidad, por lo que la investigadora tuvo que inferir las visiones de las participantes basado en lo que estas manifestaron en su practica didactica. Dos maestras coinciden en una vision constructivista social de la construccion del conocimiento, del aprendizaje y de los metodos didacticos. La otra manifesto una vision constructivista piagetiana en el aprendizaje, los metodos didacticos y en la construccion del conocimiento. Se espera que este trabajo, ademas de promover los estudios de caso sobre el enfoque constructivista de ensenanza en el contexto puertorriqueno, sirva para que los maestros, que estan transformando su enfoque educativo de uno tradicional a uno constructivista, tengan una vision mas clara de la implantacion de este enfoque. Se espera ademas que sirva para que el Departamento de Educacion y sus programas de adiestramiento y readiestramiento en servicio, asi como las universidades y sus programas de preparacion de maestros, tomen en cuenta los resultados y recomendaciones de este estudio al revisar sus programas.

  11. Using Del-1 to Tip the Angiogenic Balance in Endothelial Cells in Modular Constructs

    PubMed Central

    Ciucurel, Ema C.; Vlahos, Alexander E.

    2014-01-01

    Modular tissue engineering is a method of building vascularized tissue-engineered constructs. Submillimeter-sized collagen pieces (modules) coated with a layer of endothelial cells (EC; vascular component), and with embedded functional cells, are self-assembled into a larger, three-dimensional tissue. In this study, we examined the use of developmental endothelial locus-1 (Del-1), an extracellular matrix protein with proangiogenic properties, as a means of tipping the angiogenic balance in human umbilical vein endothelial cells incorporated in modular tissue-engineered constructs. The motivation was to enhance the vascularization of these constructs upon transplantation in vivo, in this case, without the use of exogenous mesenchymal stromal cells. EC were transduced using a lentiviral construct to overexpress Del-1. The Del-1 EC formed more sprouts in a fibrin gel sprouting assay in vitro compared with eGFP (control) transduced EC, as expected. Del-1 EC had a distinct profile of gene expression (upregulation of matrix metalloproteinase-9 [MMP-9], urokinase-type plasminogen activator [uPA/PLAU], vascular endothelial growth factor [VEGF-A], and intercellular adhesion molecule-1 [ICAM-1]; downregulation of angiopoietin-2 [Ang2]), also supporting the notion of “tipping the angiogenic balance”. On the other hand, contrary to our expectations, when Del-1 EC-coated modules were implanted subcutaneously in a severe combined immunodeficient/beige animal model, the proangiogenic effect of Del-1 was less remarkable. There was only a small increase in the number of blood vessels formed in Del-1 implants compared with the eGFP implants, and only few blood vessels formed at the implant site in both cases. This was presumed due to limited EC survival after transplantation. We speculate that if we could improve EC survival in our study (for example, by adding other prosurvival factors or supporting cells), we would see a greater Del-1-induced angiogenic benefit in vivo as a consequence of increased Del-1 secretion by a higher number of surviving cells. PMID:24138448

  12. LII Curso Internacional de Edafologa, Fertilidad de Suelos y Biologa Vegetal -Especialidad "Fertilidad de suelos y nutricin vegetal": Estudio de la fertilidad del suelo, nutricin mineral de la planta y los

    E-print Network

    LII Curso Internacional de Edafología, Fertilidad de Suelos y Biología Vegetal CONTENIDO agricultura y al medio ambiente. Título del curso Resumen del contenido y objeto del curso Áreas de interés del curso Ciencias Agrarias y Recursos Naturales Perfil del alumno tipo. Formación académica

  13. The RGD finger of Del-1 is a unique structural feature critical for integrin binding

    SciTech Connect

    Schürpf, Thomas; Chen, Qiang; Liu, Jin-huan; Wang, Rui; Springer, Timothy A.; Wang, Jia-huai

    2012-11-13

    Developmental endothelial cell locus-1 (Del-1) glycoprotein is secreted by endothelial cells and a subset of macrophages. Del-1 plays a regulatory role in vascular remodeling and functions in innate immunity through interaction with integrin {alpha}{sub V}{beta}{sub 3}. Del-1 contains 3 epidermal growth factor (EGF)-like repeats and 2 discoidin-like domains. An Arg-Gly-Asp (RGD) motif in the second EGF domain (EGF2) mediates adhesion by endothelial cells and phagocytes. We report the crystal structure of its 3 EGF domains. The RGD motif of EGF2 forms a type II' {beta} turn at the tip of a long protruding loop, dubbed the RGD finger. Whereas EGF2 and EGF3 constitute a rigid rod via an interdomain calcium ion binding site, the long linker between EGF1 and EGF2 lends considerable flexibility to EGF1. Two unique O-linked glycans and 1 N-linked glycan locate to the opposite side of EGF2 from the RGD motif. These structural features favor integrin binding of the RGD finger. Mutagenesis data confirm the importance of having the RGD motif at the tip of the RGD finger. A database search for EGF domain sequences shows that this RGD finger is likely an evolutionary insertion and unique to the EGF domain of Del-1 and its homologue milk fat globule-EGF 8. The RGD finger of Del-1 is a unique structural feature critical for integrin binding.

  14. Prevalencia y tamizaje del Trastorno por Déficit de Atención con Hiperactividad en Costa Rica

    PubMed Central

    Weiss, Nicholas T.; Schuler, Jovita; Monge, Silvia; McGough, James J.; Chavira, Denise; Bagnarello, Monica; Herrera, Luis Diego; Mathews, Carol A.

    2015-01-01

    Resumen La investigación tuvo como propósito estimar la prevalencia del Trastorno por Déficit de Atención con Hiperactividad (TDAH) en Costa Rica y determinar si la versión en español del cuestionario Swanson Nolan and Pelham Scale IV (SNAP-IV) es un instrumento de tamizaje útil en una población de niños y niñas escolares costarricenses. El instrumento fue entregado a padres y maestros de 425 niños entre 5 y 13 años de edad (promedio = 8.8). Todos fueron evaluados con el instrumento Swanson, Kotkin, Agler, M-Flynn and Pelham Scale (SKAMP). Su diagnóstico fue confirmado con una entrevista clínica. La sensibilidad y la especificidad del SNAP-IV fueron evaluadas como predictores de criterios de diagnóstico según el DSM-IV. La prevalencia puntual en la muestra del TDAH fue del 5%. El tamizaje más preciso lo hizo el SNAP-IV completado por el maestro en un corte de 20%, con una sensibilidad de 96% y una especificidad de un 82%. La sensibilidad de los instrumentos completados por los padres fue más baja que aquella de los maestros. El SNAP-IV completado por las maestras con un corte aislando el 20% de los mayores puntajes categorizó correctamente a un 87% de los sujetos. PMID:22432094

  15. The 1985 Nevado del Ruiz volcano catastrophe: anatomy and retrospection

    NASA Astrophysics Data System (ADS)

    Voight, Barry

    1990-07-01

    This paper seeks to analyze in an objective way the circumstances and events that contributed to the 1985 Nevado del Ruiz catastrophe, in order to provide useful guidelines for future emergencies. The paper is organized into two principal parts. In the first part, an Anatomy of the catastrophe is developed as a step-by-step chronicle of events and actions taken by individuals and organizations during the period November 1984 through November 1985. This chronicle provides the essential background for the crucial events of November 13. This year-long period is broken down further to emphasize essential chapters: the gradual awareness of the awakening of the volcano; a long period of institutional skepticism reflecting an absence of credibility; the closure of the credibility gap with the September 11 phreatic eruption, followed by an intensive effort to gird for the worst; and a detailed account of the day of reckoning. The second part of the paper, Retrospection, examines the numerous complicated factors that influenced the catastrophic outcome, and attempts to cull a few "lessons from Armero" in order to avoid similar occurrences in the future. In a nutshell, the government on the whole acted responsibly but was not willing to bear the economic or political costs of early evacuation or a false alarm. Science accurately foresaw the hazards but was insufficiently precise to render reliable warning of the crucial event at the last possible minute. Catastrophe was therefore a calculated risk, and this combination — the limitations of predication/detection, the refusal to bear a false alarm and the lack of will to act on the uncertain information available — provided its immediate and most obvious causes. But because the crucial event occurred just two days before the Armero emergency-management plan was to be critically examined and improved, the numerous circumstances which delayed progress of emergency management over the previous year also may be said to have contributed to the outcome. Thus the catastrophe was not caused by technological ineffectiveness or detectiveness, nor by an overwhelming eruption, or by an improbable run of bad luck, but rather by cumulative human error — by misjudgment, indecision and bureaucratic shortsightedness. Armero could have produces no victims, and therein dwells its immense tragedy.

  16. The 1985 Nevado del Ruiz volcano catastrophe: anatomy and retrospection

    NASA Astrophysics Data System (ADS)

    Voight, Barry

    1990-12-01

    This paper seeks to analyze in an objective way the circumstances and events that contributed to the 1985 Nevado del Ruiz catastrophe, in order to provide useful guidelines for future emergencies. The paper is organized into two principal parts. In the first part, an Anatomy of the catastrophe is developed as a step-by-step chronicle of events and actions taken by individuals and organizations during the period November 1984 through November 1985. This chronicle provides the essential background for the crucial events of November 13. This year-long period is broken down further to emphasize important chapters: the gradual awareness of the awakening of the volcano; a long period of institutional skepticism reflecting an absence of credibility; the closure of the credibility gap with the September 11 phreatic eruption, followed by an intensive effort to gird for the worst; and a detailed account of the day of reckoning. The second part of the paper, Retrospection, examines the numerous complicated factors that influenced the catastrophic outcome, and attempts to cull a few "lessons from Armero" in order to avoid similar occurrences in the future. In a nutshell, the government on the whole acted responsibly but was not willing to bear the economic or political costs of early evacuation or a false alarm. Science accurately foresaw the hazards but was insufficiently precise to render reliable warning of the crucial event at the last possible minute. Catastrophe was therefore a calculated risk, and this combination - the limitations of prediction/detection, the refusal to bear a false alarm and the lack of will to act on the uncertain information available - provided its immediate and most obvious causes. But because the crucial event occurred just two days before the Armero emergency management plan was to be critically examined and improved, the numerous circumstances which delayed progress of emergency management over the previous year also may be said to have contributed to the outcome. Thus the catastrophe was not caused by technological ineffectiveness or defectiveness, nor by an overwhelming eruption, or by an improbable run of bad luck, but rather by cumulative human error - by misjudgment, indecision and bureaucratic shortsightedness. Armero could have produced no victims, and therein dwells its immense tragedy.

  17. L'eliosismologia: onde sismiche per studiare l'interno del Sole

    NASA Astrophysics Data System (ADS)

    Di Mauro, M. P.

    2014-12-01

    Negli ultimi cinquanta anni siamo stati testimoni di una straordinaria rivoluzione della conoscenza e comprensione della nostra stella grazie alla nascita dell'Eliosismologia, lo studio delle oscillazioni solari. Analogamente a ciò che accade nella Terra durante i terremoti, anche l'interno del Sole è pervaso continuamente da onde sismiche che provocano piccole oscillazioni, ovvero deformazioni della fotosfera. Le oscillazioni sono la manifestazione di diversi processi che avvengono all'interno della struttura del Sole e le frequenze sismiche dei modi osservati e misurati sulla superficie sono legate direttamente ai parametri fisici degli strati interni attraversati dalle onde sismiche. Lo studio delle oscillazioni rappresenta, quindi, l'unico metodo diretto per studiare la struttura e la dinamica interna del Sole. In questo articolo verranno illustrate le caratteristiche generali delle oscillazioni solari e verranno presentati i risultati importanti e i progressi notevoli raggiunti grazie all'Eliosismologia.

  18. Observaciones del disco solar y de una protuberancia quiescente en radiación ultravioleta

    NASA Astrophysics Data System (ADS)

    Cirigliano, D.; Vial, J.-C.; Rovira, M.

    Observaciones del disco solar y de una protuberancia quiescente en el rango de longitudes de onda ultravioleta fueron obtenidas con el instrumento CDS (Coronal Diagnostic Spectrograph) y SUMER (Solar Ultraviolet Measurements of emitted radiation) a bordo de la sonda SOHO. El propósito es investigar las velocidades macroscópicas de varias especies metálicas que se observan tanto en el disco solar como en el plasma de las protuberancias. Para calcular las velocidades del disco solar aplicamos una técnica mixta para modelar la distribución de estructuras en UV en el Sol quieto. Las velocidades macroscópicas en las protuberancias se calcularon a partir de los corrimientos Doppler en cada línea espectral y luego se tomaron las del disco solar como referencia. Obtuvimos valores absolutos para las velocidades macroscópicas entre 5 y 40 km/seg. También detectamos comportamientos diferentes en las velocidades de las protuberancias en el centro con respecto a los bordes.

  19. Relevamiento total del hemisferio sur celeste en la frecuencia de 1420 MHz

    NASA Astrophysics Data System (ADS)

    Bava, J. A.; Colomb, F. R.; Hurrel, E.; Larrarte, J. J.; Sanz, A. J.; Testori, J. C.; Reich, P.; Reich, W.; Wielebinski, R.

    En el presente artículo se describe el relevamiento del cielo en el Hemisferio Sur Celeste en la frecuencia de 1420 MHz para declinaciones ?<= -19o realizado con la Antena II de 30 metros de diámetro del IAR. Este relevamiento posee igual sensibilidad (3xr.m.s=50 mK) que el realizado en el Hemisferio Norte con el radiotelescopio de 25 metros de Stockert de la Universidad de Bonn, operado por el Max-Planck Institute für Radioastronomie ( Reich W., 1982, A&ASS 48, 219; Reich P. and Reich W., 1986, A&ASS 63, 205). Con los datos obtenidos por ambos radiotelescopios se posee una base de datos de todo el cielo en esta frecuencia. En esta publicación presentamos los detalles del sistema receptor, técnicas de observación y reducción de datos, calibración y discusión de los errores en los resultados.

  20. Integrated global background monitoring network. Preliminary results from Torres del Paine and Olympic National Parks

    SciTech Connect

    Wiersma, G.B.; Kohler, A.; Boelcke, C.; Baker, G.; Harmon, M.; Weber, C.; Gonzales, J.

    1985-10-01

    During 1984, a pilot project was initiated for monitoring pollution at Torres del Paine National Park in southern Chile and Olympic National Park in the United States. These are two of three initial sites that are to be established as part of an integrated global backgound monitoring network. Eventually, the plan is to establish a world-wide system of such sites. We collected and analyzed samples of the soil, water, air, and two species of plants (moss and lichen). We also collected and analyzed samples of the forest litter. We compared the samples of soil and vegetation against reference samples. We also compared samples of soil, vegetation, and of organic material from Torres del Paine against similar samples from Olympic and Sequoia-Kings Canyon National Parks in the United States. Although the data is preliminary, it is in agreement with out initial hypothesis that Torres del Paine and Olympic National Parks are not a polluted sites.

  1. Biotic association and palaeoenvironmental reconstruction of the "Loma del Pterodaustro" fossil site (Early Cretaceous, Argentina)

    USGS Publications Warehouse

    Chiappe, L.; Rivarola, D.; Cione, A.; Fregenal-Martinez, M.; Sozzi, H.; Buatois, L.; Gallego, O.; Laza, J.; Romero, E.; Lopez-Arbarello, A.; Buscalioni, A.; Marsicano, C.; Adamonis, S.; Ortega, F.; McGehee, S.; Di, Iorio O.

    1998-01-01

    A sedimentological analysis of the basal section of the Early Cretaceous, lacustrine Lagarcito Formation at "Loma del Pterodaustro" (San Luis, Argentina) and a summary of its biological components are presented. Three sedimentological facies can be recognized in the basal sequence of the Lagarcito Formation. Fossil remains are particularly abundant in laminated claystones of a facies interpreted as deposits formed in offshore areas of the lake. The preservation of delicate structures allows recognition of these deposits as a Konservat Lagersta??tte. Up to now, rocks at "Loma del Pterodaustro" have yielded plants, conchostracans, semionotid and pleuropholid fishes, pterodactyloid pterosaurs, and a variety of invertebrate traces. The chronology of the Lagarcito Formation is discussed and it is concluded that this unit is of Albian age. The palaeoenvironment of deposition of the basal sequence of the Lagarcito Formation at "Loma del Pterodaustro" is interpreted as a perennial, shallow lake developed within an alluvial plain, under semiarid climatic conditions.

  2. Haplotype analysis of the 185delAG BRCA1 mutation in ethnically diverse populations

    PubMed Central

    Laitman, Yael; Feng, Bing-Jian; Zamir, Itay M; Weitzel, Jeffrey N; Duncan, Paul; Port, Danielle; Thirthagiri, Eswary; Teo, Soo-Hwang; Evans, Gareth; Latif, Ayse; Newman, William G; Gershoni-Baruch, Ruth; Zidan, Jamal; Shimon-Paluch, Shani; Goldgar, David; Friedman, Eitan

    2013-01-01

    The 185delAG* BRCA1 mutation is encountered primarily in Jewish Ashkenazi and Iraqi individuals, and sporadically in non-Jews. Previous studies estimated that this is a founder mutation in Jewish mutation carriers that arose before the dispersion of Jews in the Diaspora ?2500 years ago. The aim of this study was to assess the haplotype in ethnically diverse 185delAG* BRCA1 mutation carriers, and to estimate the age at which the mutation arose. Ethnically diverse Jewish and non-Jewish 185delAG*BRCA1 mutation carriers and their relatives were genotyped using 15 microsatellite markers and three SNPs spanning 12.5?MB, encompassing the BRCA1 gene locus. Estimation of mutation age was based on a subset of 11 markers spanning a region of ?5?MB, using a previously developed algorithm applying the maximum likelihood method. Overall, 188 participants (154 carriers and 34 noncarriers) from 115 families were included: Ashkenazi, Iraq, Kuchin-Indians, Syria, Turkey, Iran, Tunisia, Bulgaria, non-Jewish English, non-Jewish Malaysian, and Hispanics. Haplotype analysis indicated that the 185delAG mutation arose 750–1500 years ago. In Ashkenazim, it is a founder mutation that arose 61 generations ago, and with a small group of founder mutations was introduced into the Hispanic population (conversos) ?650 years ago, and into the Iraqi–Jewish community ?450 years ago. The 185delAG mutation in the non-Jewish populations in Malaysia and the UK arose at least twice independently. We conclude that the 185delAG* BRCA1 mutation resides on a common haplotype among Ashkenazi Jews, and arose about 61 generations ago and arose independently at least twice in non-Jews. PMID:22763381

  3. An unexpected effect of TNF-? on F508del-CFTR maturation and function

    PubMed Central

    Bitam, Sara; Urbach, Valérie; Sermet-Gaudelus, Isabelle; Hinzpeter, Alexandre; Edelman, Aleksander

    2015-01-01

    Cystic fibrosis (CF) is a multifactorial disease caused by mutations in the cystic fibrosis transmembrane conductance regulator gene ( CFTR), which encodes a cAMP-dependent Cl - channel. The most frequent mutation, F508del, leads to the synthesis of a prematurely degraded, otherwise partially functional protein. CFTR is expressed in many epithelia, with major consequences in the airways of patients with CF, characterized by both fluid transport abnormalities and persistent inflammatory responses. The relationship between the acute phase of inflammation and the expression of wild type (WT) CFTR or F508del-CFTR is poorly understood. The aim of the present study was to investigate this effect. The results show that 10 min exposure to TNF-alpha (0.5-50ng/ml) of F508del-CFTR-transfected HeLa cells and human bronchial cells expressing F508del-CFTR in primary culture (HBE) leads to the maturation of F508del-CFTR and induces CFTR chloride currents. The enhanced CFTR expression and function upon TNF? is sustained, in HBE cells, for at least 24 h. The underlying mechanism of action involves a protein kinase C (PKC) signaling pathway, and occurs through insertion of vesicles containing F508del-CFTR to the plasma membrane, with TNF? behaving as a corrector molecule. In conclusion, a novel and unexpected action of TNF? has been discovered and points to the importance of systematic studies on the roles of inflammatory mediators in the maturation of abnormally folded proteins in general and in the context of CF in particular. PMID:26594334

  4. Development and Utilization of InDel Markers to Identify Peanut (Arachis hypogaea) Disease Resistance

    PubMed Central

    Liu, Lifeng; Dang, Phat M.; Chen, Charles Y.

    2015-01-01

    Peanut diseases, such as leaf spot and spotted wilt caused by Tomato Spotted Wilt Virus, can significantly reduce yield and quality. Application of marker assisted plant breeding requires the development and validation of different types of DNA molecular markers. Nearly 10,000 SSR-based molecular markers have been identified by various research groups around the world, but less than 14.5% showed polymorphism in peanut and only 6.4% have been mapped. Low levels of polymorphism limit the application of marker assisted selection (MAS) in peanut breeding programs. Insertion/deletion (InDel) markers have been reported to be more polymorphic than SSRs in some crops. The goals of this study were to identify novel InDel markers and to evaluate the potential use in peanut breeding. Forty-eight InDel markers were developed from conserved sequences of functional genes and tested in a diverse panel of 118 accessions covering six botanical types of cultivated peanut, of which 104 were from the U.S. mini-core. Results showed that 16 InDel markers were polymorphic with polymorphic information content (PIC) among InDels ranged from 0.017 to 0.660. With respect to botanical types, PICs varied from 0.176 for fastigiata var., 0.181 for hypogaea var., 0.306 for vulgaris var., 0.534 for aequatoriana var., 0.556 for peruviana var., to 0.660 for hirsuta var., implying that aequatoriana var., peruviana var., and hirsuta var. have higher genetic diversity than the other types and provide a basis for gene functional studies. Single marker analysis was conducted to associate specific marker to disease resistant traits. Five InDels from functional genes were identified to be significantly correlated to tomato spotted wilt virus (TSWV) infection and leaf spot, and these novel markers will be utilized to identify disease resistant genotype in breeding populations. PMID:26617627

  5. Conference Report: Sesión consagrada al teatro cubano del exilio durante el congreso ´Cuba: Exilio y cultura´

    E-print Network

    Febles, Jorge

    2000-04-01

    Sesión consagrada al teatro cubano del exilio durante el congreso "Cuba: Exilio y cultura" Jorge Febles Del 7 al 9 de octubre de 1999, bajo los auspicios de la Asociación Nacional de Educadores Cubano-Americanos y Herencia Cultural Cubana, tuvo lugar... en el hotel Dadeland Marriott de la ciudad de Miami el congreso "Cuba: Exilio y cultura." El encuentro tenía como fin primordial dar a conocer las contribuciones que los exiliados cubanos han hecho a la cultura de los Estados Unidos y, por supuesto...

  6. Sor Juana's Baroque Martyr-Auto, El mártir del Sacramento, San Hermenegildo

    E-print Network

    Daniel, Lee A.

    1994-10-01

    Juana's Baroque Martyr-A ato, El mártir del Sacramento, San Hermenegildo Lee A. Daniel The last of the trilogy of Sorjuanian autos, El mártir del Sacramento, San Hermenegildo (1692), is set in the Spanish Visigothic period and is based on the legend... of Hermenegildo, a popular theme of the 1600s. Despite a number of previous dramatizations of the theme in Spain, such as seventeenth-century hagiographic autos like Las once mil vírgenes, San Lorenzo, El Santo Rey Don Fernando, and El gran Duque de Gandía, San...

  7. A review on Balanites aegyptiaca Del (desert date): phytochemical constituents, traditional uses, and pharmacological activity

    PubMed Central

    Chothani, Daya L.; Vaghasiya, H. U.

    2011-01-01

    Balanites aegyptiaca Del. (Zygophyllaceae), known as ‘desert date,’ is spiny shrub or tree up to l0 m tall, widely distributed in dry land areas of Africa and South Asia. It is traditionally used in treatment of various ailments i.e. jaundice, intestinal worm infection, wounds, malaria, syphilis, epilepsy, dysentery, constipation, diarrhea, hemorrhoid, stomach aches, asthma, and fever. It contains protein, lipid, carbohydrate, alkaloid, saponin, flavonoid, and organic acid. Present review summarizes the traditional claims, phytochemistry, and pharmacology of B. aegyptiaca Del reported in scientific literature. PMID:22096319

  8. Historical survey of the national astronomical observatory in Llano del Hato

    NASA Astrophysics Data System (ADS)

    Martinez Picar, Antonio; Salas Ramirez, Henry

    2007-12-01

    The Centro de Investigaciones de Astronomia (CIDA), the Venezuelan Institute in charge for managing human- and technical resources of the National Astronomical Observatory in Llano del Hato, is one of the younger institutes in its field. However, its foundation is surrounded by a series of curious and interesting eyents that go back to the end of the 18th century. Its equatoriallocation, excellent astronomical equipment and the high-qualified personnel offers a geographical and technical advantage. The paper is a historical oveniew of events, facts and demonstrations of the human activity related to the conception, building and starting the Llano del Hato National Astronomical Observatory.

  9. Molde de cemento para la superficie superior del molde de compresin de un pie protesico Shape&Roll.

    E-print Network

    Chisholm, Rex L.

    Molde de cemento para la superficie superior del molde de compresión de un pie protesico Shape Andrew Hansen, PhD. #12;Page 2 Arriba se muestra una palanca para hacer moldes de compresión que permitan superior, con cemento. El manual titulado "Realizar una bandeja de Cemento para el Molde de compresión del

  10. Resultado negativo de prueba del VPH es mejor predictor de riesgo bajo de cáncer de cuello uterino

    Cancer.gov

    De acuerdo con un estudio en el que participaron más de un millón de mujeres, los investigadores del NCI han determinado que el resultado negativo de una prueba para la detección del VPH proporciona mayor certeza o seguridad frente a riesgos futuros de cá

  11. D.G. SCOTT HUBBARD D.G. Scott Hubbard es el Director del Centro de Investigacin de NASA

    E-print Network

    Cardeñosa, Jesús

    D.G. SCOTT HUBBARD D.G. Scott Hubbard es el Director del Centro de Investigación de NASA Ames en Investigación NASA. Previamente a su nombramiento como Director de Ames, fue Vice- Director de Investigación en NASA Ames. Sirvió recientemente como único representante de NASA en la Comisión de Investigación del

  12. 75 FR 39668 - Notice of Availability of Final Environmental Impact Statement for the Proposed Rio del Oro...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-12

    ... (FEIS) for the Rio del Oro Specific Plan Project, a proposed master-planned, mixed use development... Register (71 FR 71142), informing the public of the availability of the Draft Environmental Impact... a mixed- use development in the approximately 3,828-acre Rio del Oro Specific Plan Area. In...

  13. Further evidence that the sound-speed algorithm of Del Grosso is more accurate than that of Chen and Millero

    E-print Network

    Rhode Island, University of

    algorithm also consis- tently predicts higher sound speeds in the deep water than Del Grosso's algorithm algorithms. This study was based upon 11 PIES records which have one or more full-water-column CTD profilesFurther evidence that the sound-speed algorithm of Del Grosso is more accurate than that of Chen

  14. Erosin de suelo y mapa de riesgo para la cuenca del Ro Grande de Aasco, Puerto Rico

    E-print Network

    Gilbes, Fernando

    Erosión de suelo y mapa de riesgo para la cuenca del Río Grande de Añasco, Puerto Rico Ángel A hidrográficas. La erosión del suelo es un aspecto que requiere de capital y tiempo para su evaluación. Una serie de modelos paramétricos se han desarrollado para predecir la erosión de los suelos en las cuencas

  15. REGLAMENTO DE LA LEY DE BIOSEGURIDAD DE ORGANISMOS GENTICAMENTE MODIFICADOS CMARA DE DIPUTADOS DEL H. CONGRESO DE LA UNIN

    E-print Network

    salud pública: Aquellos organismos cuya modificación genética tenga como objetivo generar mecanismos de Biotecnología del Convenio sobre la Diversidad Biológica; VI. SALUD: La Secretaría de Salud; VII. Secretaría la Secretaría competente o SALUD, en su caso, se deberá adjuntar copia del pago de derechos, al

  16. 75 FR 44720 - Safety Zone; Live-Fire Gun Exercise, M/V Del Monte, James River, VA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-29

    ... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA00 Safety Zone; Live-Fire Gun Exercise, M/V Del Monte... specified waters of the James River to protect mariners from the hazards associated with live fire and... conduct a live fire and explosive training event onboard the M/V Del Monte in the vicinity of the...

  17. 1. Objetivo: El sistema de Gestin de Cursos y Eventos es la herramienta del Centro Cultural Rector

    E-print Network

    Cortiñas, Guillermo

    #12;1. Objetivo: El sistema de Gestión de Cursos y Eventos es la herramienta del Centro Cultural inherentes a la gestión de cursos; tanto para los alumnos, los capacitadores; como así también a la gestión alumno en el uso del sistema de Gestión de Cursos y Eventos, para realizar el proceso de inscripción a un

  18. ASAMBLEA GENERAL ORDINARIA DE LA SOCIEDAD DE AMIGOS DEL MUSEO NACIONAL DE CIENCIAS NATURALES, 5 DE JULIO DE 2006

    E-print Network

    Fitze, Patrick

    DE JULIO DE 2006 En Madrid, a las 19:00 horas del día 5 de julio de 2006, en el Salón de Actos del Casas (Vocal) Jorge Morales Romero (Vocal) Alfonso Navas Sánchez (Vocal) Carmen Prats Joaniquet (Vocal acogidos en su momento. Se ha realizado ya la primera salida al campo, a Santa María la Real de Nieva, de

  19. 75 FR 44720 - Safety Zone; Live-Fire Gun Exercise, M/V Del Monte, James River, VA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-29

    ...USCG-2010-0585] RIN 1625-AA00 Safety Zone; Live-Fire Gun Exercise, M/V Del Monte, James River, VA AGENCY: Coast...as follows: Sec. 165.T05-0585 Safety Zone; Live-Fire Gun Exercise, M/V Del Monte, James River, VA (a)...

  20. DELIVERING TIMELY AIR QUALITY, TRAFFIC, AND WEATHER INFORMATION TO YOUR COMMUNITY/THE PASO DEL NORTE ENVIRONMENTAL MONITORING PROJECT

    EPA Science Inventory

    EPA has developed a technology transfer handbook for the EMPACT Paso del Norte Project. The EMPACT Paso del Norte Environmental Monitoring Project is a mobile vehicle emissions project that involves the international community of El Paso, TX; Sundland Park, NM; and Juarez, Mexico...

  1. 78 FR 6173 - Diana Del Grosso, Ray Smith, Joseph Hatch, Cheryl Hatch, Kathleen Kelley, Andrew Wilklund, and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-29

    ... From the Federal Register Online via the Government Publishing Office ] DEPARTMENT OF TRANSPORTATION Surface Transportation Board Diana Del Grosso, Ray Smith, Joseph Hatch, Cheryl Hatch, Kathleen... procedural schedule. SUMMARY: In response to a petition filed on August 1, 2012, by Diana Del Grosso,...

  2. 401ROL DEL MEIOBENTOS FRENTE A CHILE CENTRALRevista Chilena de Historia Natural 76: 401-415, 2003

    E-print Network

    Levin, Lisa

    401ROL DEL MEIOBENTOS FRENTE A CHILE CENTRALRevista Chilena de Historia Natural 76: 401-415, 2003 76: ¿¿-??, 2003 Composición, estructura y flujo energético del meiobentos frente a Chile central Composition, structure and energy flux of the meiobenthos off central Chile JAVIER SELLANES1, CARLOS NEIRA2

  3. I Jornadas de Violencia de Gnero, Igualdad y Justicia. Del 13 de noviembre al 18 de diciembre de 2012

    E-print Network

    Fernández Pascual, Ricardo

    I Jornadas de Violencia de Género, Igualdad y Justicia. Del 13 de noviembre al 18 de diciembre de de Murcia I Jornadas de Violencia de Género, Igualdad y Justicia. Del 13 de noviembre al 18 de 2012 INSCRIPCIÓN GRATUITA PROGRAMA DE CONFERENCIAS Martes, 13 de noviembre 19,00 HORAS. IGUALDAD Y

  4. BOLETN OFICIAL DEL ESTADO Nm. 207 Jueves 29 de agosto de 2013 Sec. II.B. Pg. 63136

    E-print Network

    Fitze, Patrick

    género en la Administración General del Estado, tiene en cuenta el principio de igualdad de trato entre del principio de igualdad de oportunidades e igualdad de trato entre hombres y mujeres en asuntos de empleo y ocupación, con el contenido de la Ley Orgánica 3/2007, de 22 de marzo, para la igualdad efectiva

  5. Avances e Innovacin en la Ciencia y Tecnologa de Productos Lcteos El objetivo del curso es profundizar en el conocimiento de los principales aspectos cientficos y tecnolgicos de los productos

    E-print Network

    Avances e Innovación en la Ciencia y Tecnología de Productos Lácteos El objetivo del curso es en las prácticas. Título del curso Resumen del contenido y objeto del curso Áreas de interés del curso CIENCIA Y TECNOLOGÍA DE ALIMENTOS Perfil del alumno tipo. Formación académica LICENCIADO

  6. INJECTIVE COLOURING OF BINOMIAL RANDOM GRAPHS RITA M. DEL RIO-CHANONA, CALUM MACRURY, JAKE NICOLAIDIS,

    E-print Network

    Pralat, Pawel

    of a graph is a labelling of its vertices with colours such that no two vertices sharing the same edge haveINJECTIVE COLOURING OF BINOMIAL RANDOM GRAPHS RITA M. DEL R´IO-CHANONA, CALUM MACRURY, JAKE number of a graph G is the minimum number of colours needed to colour the vertices of G so that two

  7. 33 CFR 162.35 - Channel of Christina River, Del.; navigation.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 2 2011-07-01 2011-07-01 false Channel of Christina River, Del.; navigation. 162.35 Section 162.35 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) PORTS AND WATERWAYS SAFETY INLAND WATERWAYS NAVIGATION REGULATIONS § 162.35 Channel...

  8. 33 CFR 162.35 - Channel of Christina River, Del.; navigation.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Channel of Christina River, Del.; navigation. 162.35 Section 162.35 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) PORTS AND WATERWAYS SAFETY INLAND WATERWAYS NAVIGATION REGULATIONS § 162.35 Channel...

  9. 33 CFR 162.35 - Channel of Christina River, Del.; navigation.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 2 2013-07-01 2013-07-01 false Channel of Christina River, Del.; navigation. 162.35 Section 162.35 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) PORTS AND WATERWAYS SAFETY INLAND WATERWAYS NAVIGATION REGULATIONS § 162.35 Channel...

  10. 33 CFR 162.35 - Channel of Christina River, Del.; navigation.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 2 2012-07-01 2012-07-01 false Channel of Christina River, Del.; navigation. 162.35 Section 162.35 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) PORTS AND WATERWAYS SAFETY INLAND WATERWAYS NAVIGATION REGULATIONS § 162.35 Channel...

  11. Plan Multinacional de Educacion del Adulto (Multinational Plan for Adult Education).

    ERIC Educational Resources Information Center

    Eduplan Informa, 1971

    1971-01-01

    This document contains part of the final report from the first meeting of the Inter-American Council on Education, Science, and Culture, held in Vina del Mar, Chile, in 1970. The report presents general policy and guidelines which should be followed in the establishment of adult elementary education programs. The general discussion covers literacy…

  12. Oficina para Prcticas Externas y Empleabilidad CONVOCATORIA ORDINARIA DEL AO 2016 PARA PRCTICAS REMUNERADAS DE LA

    E-print Network

    Autonoma de Madrid, Universidad

    Baena Preysler (Dep. Prehistoria y Arqueología UAM; javier.baena@uam.es) ACTIVIDADES A REALIZAR manejo y control de páginas web, blogs y otras vías de difusión de las actividades del laboratorio en arqueología, etc.). -Formación en el manejo y control de páginas web, blogs así como en la

  13. Oficina para Prcticas Externas y Empleabilidad (OPE) CONVOCATORIA ORDINARIA DEL AO 2015 PARA PRCTICAS REMUNERADAS DE

    E-print Network

    Autonoma de Madrid, Universidad

    : 600 Euros brutos/mes TUTOR PROFESIONAL: Javier Baena Preysler (Dep. Prehistoria y Arqueología UAM web, blogs y otras vías de difusión de las actividades del laboratorio. -Apoyo a la organización y y control de páginas web, blogs así como en la creación, manipulación y análisis de registros

  14. Preservation of fungi in archaeological charcoal M. Moskal-del Hoyo a,*, M. Wachowiak b,1

    E-print Network

    Blanchette, Robert A.

    Preservation of fungi in archaeological charcoal M. Moskal-del Hoyo a,*, M. Wachowiak b,1 , R February 2010 Keywords: Wood charcoal Fungal attack Biodeterioration Deadwood collection Anthracology Archaeobotany a b s t r a c t During the analysis of wood charcoal remains from archaeological sites

  15. Publicación de Propuesta Presupuestaria del NCI para el Año Fiscal 2017

    Cancer.gov

    Ayer, tuve el honor de presentar al Presidente Barack Obama el Plan Anual del NCI y Propuesta Presupuestaria para el Año Fiscal 2017. Creo que la “Propuesta Presupuestaria”, como se conoce ahora, es especialmente importante este año para la investigación oncológica por dos razones.

  16. Tendencias del cáncer: Influjo en la atención y en prioridades de investigación

    Cancer.gov

    Muchas de las tendencias que observamos en el cáncer están cambiando cómo vemos el cáncer y cómo respondemos a él, desde impulsar la investigación hasta identificar las causas fundamentales de los cánceres que están aumentando en incidencia para dar forma a la investigación sobre el tratamiento y la prevención del cáncer.

  17. Ouabain Mimics Low Temperature Rescue of F508del-CFTR in Cystic Fibrosis Epithelial Cells

    PubMed Central

    Zhang, Donglei; Ciciriello, Fabiana; Anjos, Suzana M.; Carissimo, Annamaria; Liao, Jie; Carlile, Graeme W.; Balghi, Haouaria; Robert, Renaud; Luini, Alberto; Hanrahan, John W.; Thomas, David Y.

    2012-01-01

    Most cases of cystic fibrosis (CF) are caused by the deletion of a single phenylalanine residue at position 508 of the cystic fibrosis transmembrane conductance regulator (CFTR). The mutant F508del-CFTR is retained in the endoplasmic reticulum and degraded, but can be induced by low temperature incubation (29°C) to traffic to the plasma membrane where it functions as a chloride channel. Here we show that, cardiac glycosides, at nanomolar concentrations, can partially correct the trafficking of F508del-CFTR in human CF bronchial epithelial cells (CFBE41o-) and in an F508del-CFTR mouse model. Comparison of the transcriptional profiles obtained with polarized CFBE41o-cells after treatment with ouabain and by low temperature has revealed a striking similarity between the two corrector treatments that is not shared with other correctors. In summary, our study shows a novel function of ouabain and its analogs in the regulation of F508del-CFTR trafficking and suggests that compounds that mimic this low temperature correction of trafficking will provide new avenues for the development of therapeutics for CF. PMID:23060796

  18. Functional Rescue of F508del-CFTR Using Small Molecule Correctors

    PubMed Central

    Molinski, Steven; Eckford, Paul D. W.; Pasyk, Stan; Ahmadi, Saumel; Chin, Stephanie; Bear, Christine E.

    2012-01-01

    High-throughput screens for small molecules that are effective in “correcting” the functional expression of F508del-CFTR have yielded several promising hits. Two such compounds are currently in clinical trial. Despite this success, it is clear that further advances will be required in order to restore 50% or greater of wild-type CFTR function to the airways of patients harboring the F508del-CFTR protein. Progress will be enhanced by our better understanding of the molecular and cellular defects caused by the F508del mutation, present in 90% of CF patients. The goal of this chapter is to review the current understanding of defects caused by F508del in the CFTR protein and in CFTR-mediated interactions important for its biosynthesis, trafficking, channel function, and stability at the cell surface. Finally, we will discuss the gaps in our knowledge regarding the mechanism of action of existing correctors, the unmet need to discover compounds which restore proper CFTR structure and function in CF affected tissues and new strategies for therapy development. PMID:23055971

  19. Flujomultfaseenlacelda16delCabril Flujo multifases en la celda 16 de "El Cabril"

    E-print Network

    Politècnica de Catalunya, Universitat

    ;Flujomultfaseenlacelda16delCabril Unos cálculos Dos suelos separados por aire con temperatura diferente cuando ya no hay flujo difusivo de vapor. 0 0difj e= = aireSuelo Suelo T = 200C Pmat = 0 T = 200C + T Pmat = ? 0 2 4 6

  20. Investigacin Centro de Investigacin y de Estudios Avanzados del Instituto Politcnico Nacional

    E-print Network

    moleculares microbianos en suelos. Ana Carmela Ramos Valdivia Biotecnología del metabolismo secundario y la interés industrial Refugio Rodríguez Vázquez Biorremediación de suelo y agua. Aplicación de residuos agroindustriales en la biorremediación de suelos, enzimas fúngicas en la degradación de compuestos orgánicos

  1. A Failed Utopia in Marcela Del Río's "Proceso a Faubritten"

    ERIC Educational Resources Information Center

    Manickam, Samuel

    2014-01-01

    In Marcela del Río's science fiction novel "Proceso a Faubritten," utopia comes in the form of eternal life for all of humanity, thanks to Dr. Alexander Faubritten's "Bomba L." This polyphonic work includes diaries by Faubritten and his Mexican lover, María Corona. In my analysis of these two diaries, I will show how…

  2. DERECHOS Y RESPONSABILIDADES DEL EMPLEADO BAJO LA LEY DE AUSENCIA FAMILIAR Y MDICA

    E-print Network

    DERECHOS Y RESPONSABILIDADES DEL EMPLEADO BAJO LA LEY DE AUSENCIA FAMILIAR Y MÉDICA Derechos al empleado desempeñar su puesto. Derechos de Ausencia Para Familias Militares Empleados elegibles, pueden usar su derecho de ausencia de 12 semanas para atender ciertas exigencias calificadoras. Las

  3. pag. 2S. Marsili-Libelli: Il Modello ASM1 Origini del modello n. 1

    E-print Network

    : Cinetiche di Monod bi-substrato Ciclo batterico basato su Death-Regeneration Suddivisione del COD materiali riciclabili per una frazione 1-fP, senza consumo di ossigeno Suddivisione COD Il COD particolato in soluzione 22s 2 11s 1 max SK S SK S ++ SSXS hydrolysis COD particolato COD solubile XH SS XI death

  4. Dynamics of the Formation and Decay of Coherence in a Polariton Condensate E. del Valle,1

    E-print Network

    Viña, Luis

    Dynamics of the Formation and Decay of Coherence in a Polariton Condensate E. del Valle,1 D the dynamics of the formation and decay of a condensate of microcavity polaritons. We investigate alternative to investigate the process of condensate forma- tion is that of microcavity polaritons [1

  5. ATMOSPHERIC VOLATILE ORGANIC COMPOUND MEASUREMENTS DURING THE 1996 PASO DEL NORTE OZONE STUDY

    EPA Science Inventory

    Ambient air VOC samples were collected at surface air quality monitoring sites, near sources of interest, and aloft on the US (El Paso) and Mexican (Ciudad Juarez) side of the border during a six-week period of the 1996 Paso del Norte Ozone Study. Samples were collected at five...

  6. DISYUNTIVAS EN LAS CONCEPCIONES SOBRE AUTONOMÍA Y BENEFICENCIA QUE AFECTAN LA TERAPÉUTICA DEL INTENTO SUICIDA.

    PubMed

    Mondragón, Liliana; Monroy, Zuraya; Ito, Ma Emily; Medina-Mora, Dra Ma Elena

    2010-06-01

    El objetivo del trabajo es conocer las disyuntivas entre los principios de beneficencia y autonomía, que se presentan en la relación médico-paciente, durante la terapéutica del intento de suicidio.La investigación se realizó en dos hospitales psiquiátricos de la Ciudad de México. La muestra incluyó a tres sujetos con intento de suicidio, mayores de 18 años, que eran atendidos en consulta externa a causa de una lesión autoinfligida en el último año, y a tres psiquiatras que trataban a estos pacientes. La información se obtuvo previo consentimiento informado en entrevistas individuales. Se llevó a cabo un análisis de discurso argumentado para encontrar los significados que los participantes otorgaron a los principios bioéticos y las posibles disyuntivas entre éstos.Las discordancias entre la beneficencia y la autonomía estuvieron relacionadas con el beneficio del tratamiento, el respeto por los valores y las creencias de los pacientes, entre otros. Este trabajo presenta consideraciones éticas relevantes en el escenario clínico, al ofrecer al psiquiatra un análisis bioético que le permita actuar de acuerdo con la beneficencia y respetando la autonomía del paciente frente a casos de intento de suicidio y, de esta forma procurar una mejor atención para ellos. PMID:20830214

  7. Centro de Contacto del NCI—Servicio de Información sobre el Cáncer

    Cancer.gov

    El Instituto Nacional del Cáncer (NCI) ofrece información actualizada, precisa, confiable y fácil de entender sobre diferentes de temas de cáncer. Los especialistas en información le pueden ayudar en el teléfono 1-800-422-6237 (1-800-4-CANCER).

  8. Constraints on Saturn's tropospheric general circulation from Cassini ISS images Anthony D. Del Genio a,

    E-print Network

    Constraints on Saturn's tropospheric general circulation from Cassini ISS images Anthony D. Del Saturn, Atmosphere a b s t r a c t An automated cloud tracking algorithm is applied to Cassini Imaging Science Subsystem high-resolution apoapsis images of Saturn from 2005 and 2007 and moderate resolution

  9. Genetic structuring in the threatened ``Lagartijo del Bosque Seco" (Anolis cooki) from Puerto Rico

    E-print Network

    Leal, Manuel S.

    Genetic structuring in the threatened ``Lagartijo del Bosque Seco" (Anolis cooki) from Puerto Rico of the Caribbean Island of Puerto Rico. Maximum likelihood and Bayesian methods revealed relatively shallow genetic in mainland Puerto Rico. Despite this pattern, specimens from the same geographic area tended to nest together

  10. Valutazione preliminare del rischio stress lavoro correlato Calcolo Totale Punteggio Rischio

    E-print Network

    Di Pillo, Gianni

    .3 CARICO DI LAVORO - RITMO DI LAVORO 2,24 - 2 II.4 ORARIO DI LAVORO 1,51 - 2 TOTALE PUNTEGGIO AREA 8 - CONCILIAZIONE VITA/LAVORO* 2,31 0,00 0 TOTALE PUNTEGGIO AREA 10,47 10 AREA TOTALE PUNTEGGIO PER AREA ARR RISCHIO 21 Legenda Identificazione fattori di rischio Non rilevante Medio Alto II. AREA CONTENUTO DEL

  11. LEY DE BIOSEGURIDAD DE ORGANISMOS GENTICAMENTE MODIFICADOS CMARA DE DIPUTADOS DEL H. CONGRESO DE LA UNIN

    E-print Network

    los posibles riesgos que estas actividades pudieran ocasionar a la salud humana o al medio ambiente y protección de la salud humana, del medio ambiente y la diversidad biológica y de la sanidad animal, vegetal y actividades con organismos genéticamente modificados en la salud humana o en el medio ambiente y la diversidad

  12. A tectonically controlled basin-fill within the Valle del Cauca, West-Central Colombia

    SciTech Connect

    Rine, J.M.; Keith, J.F. Jr.; Alfonso, C.A.; Ballesteros, I.; Laverde, F.; Sacks, P.E.; Secor, D.T. Jr. ); Perez, V.E.; Bernal, I.; Cordoba, F.; Numpaque, L.E. )

    1993-02-01

    Tertiary strata of the Valle del Cauca reflect a forearc/foreland basin tectonic history spanning a period from pre-uplift of the Cordillera Central to initiation of uplift of the Cordillera Occidental. Stratigraphy of the Valle del Cauca begins with Jurassic-Cretaceous rocks of exotic and/or volcanic provenance and of oceanic origin. Unconformably overlying these are Eocene to Oligocene basal quartz-rich sandstones, shallow marine algal limestones, and fine-grained fluvial/deltaic mudstones and sandstones with coalbeds. These Eocene to Oligocene deposits represent a period of low tectonic activity. During late Oligocene to early Miocene, increased tectonic activity produced conglomeratic sediments which were transported from east to west, apparently derived from uplift of the Cordillera Central, and deposited within a fluvial to deltaic setting. East-west shortening of the Valle del Cauca basin folded the Eocene to early Miocene units, and additional uplift of the Cordillera Central during the later Miocene resulted in syn-tectonic deposition of alluvial fans. After additional fold and thrust deformation of the total Eocene-Miocene basin-fill, tectonic activity abated and Pliocene-Quaternary alluvial and lacustrine strata were deposited. Within the framework of this depositional and tectonic history of the Valle del Cauca, hydrocarbon exploration strategies can be formulated and evaluated.

  13. 33 CFR 162.35 - Channel of Christina River, Del.; navigation.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 2 2014-07-01 2014-07-01 false Channel of Christina River, Del.; navigation. 162.35 Section 162.35 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) PORTS AND WATERWAYS SAFETY INLAND WATERWAYS NAVIGATION REGULATIONS § 162.35 Channel...

  14. A mean field theory of sequential Monte Carlo methods P. Del Moral

    E-print Network

    Del Moral , Pierre

    A mean field theory of sequential Monte Carlo methods P. Del Moral INRIA, Centre Bordeaux-Sud Ouest Moral (INRIA Bordeaux) INRIA Centre Bordeaux-Sud Ouest, France 1 / 32 #12;Outline 1 Foundations Moral (INRIA Bordeaux) INRIA Centre Bordeaux-Sud Ouest, France 2 / 32 #12;Summary 1 Foundations

  15. LE RICERCHE DEL GRIM PALERMO Le Neuroscienze e l'insegnamento-apprendimento delle

    E-print Network

    Spagnolo, Filippo

    Scienze n. 291 (novembre 1992) #12;· Crick Francis - La scienza e l'anima - Rizzoli, Milano 1994 Maxwell W. - Lo sviluppo del cervello - Le Scienze n. 135 (novembre 1979) · Crick F.H. - Riflessioni sul cervello - Le Scienze n. 135 (novembre 1979) · Crick F.H., Koch C. - Il problema della coscienza - Le

  16. RIVISTA DEL NUOVOCIMENTO VOL. 19, N. 4 1996 N6ther symmetries in cosmology

    E-print Network

    Scudellaro, Paolo

    RIVISTA DEL NUOVOCIMENTO VOL. 19, N. 4 1996 N6ther symmetries in cosmology S. CAPOZZIELLO,R. DE cosmology 3"2. Realization of inflation 3"3. Finite-temperature field theory 3"4. Phase transitions 3"3. Example 5. Cosmological equations and NSther symmetries 5"1. Einstein equations and contracted Bianchi

  17. 508 Mastozoologa Neotropical, 2009 por la presencia del bosque nativo y la proteccin

    E-print Network

    Nacional Autónoma de México, Universidad

    , y una menor tolerancia a los cambios en el paisaje respecto al puma. Mientras las áreas aptas para el jaguar también fueron aptas para el puma, el 54% de las áreas aptas para el puma no fueron consideradas con aptitud para el jaguar, demostrando la mayor resiliencia del puma a la fragmentación y pérdida

  18. Criterios para la seleccin de condiciones de referencia en los ros mediterrneos. Resultados del proyecto GUADALMED.

    E-print Network

    Bonada, Núria

    . Valldemosa, km. 7.5. 07071 Palma de Mallorca. RESUMEN La Directiva Marco del Agua (DMA) establece la la DMA. Los resultados mostraron en muchas de las estaciones seleccionadas (un 72%) una calidad criterios, mientras que otras podrían fácilmente cumplirlos reubicando el punto de muestreo aguas arriba o

  19. Un Atlas Digital muy a la mexicana Medicin de parmetros meteorolgicos: Globo Cautivo del CCA

    E-print Network

    Grutter, Michel

    tecnológicos de punta para la realización de un proceso cartográfico, que va desde el control de calidad de los Comisión Nacional del Agua (CONAGUA), en un proyecto conjunto entre el SMN y la Unidad de Informática para, para el procesamiento de mapas de superficies climáticas, el control de calidad de la información

  20. Urban Impact of Dissolved Metals in the Paso del Norte Segment of the Rio Grande

    ERIC Educational Resources Information Center

    Freiwan, Sumayeh Ahmad

    2013-01-01

    The Paso del Norte segment of the Rio Grande experiences two seasons per year; the (wet) irrigation season and the (dry) non-irrigation season. The goal of this study was to improve the understanding of occurrence and contribution of dissolved metals in this region during the non-irrigation season. The objectives of this study were to (1) evaluate…