These are representative sample records from Science.gov related to your search topic.
For comprehensive and current results, perform a real-time search at Science.gov.
1

Las zonas mineras españolas a finales del XIX  

Microsoft Academic Search

PRESENTACIÓN Jugh James Rose, capellán de las compañías mineras inglesas, francesas y alemanas de Linares, es el autor de la obra Untrodden Spain and her black country being sketches of the life and character of the Spaniard of the interior publicada en dos volúmenes en Londres en 1875. De él sabemos que ejerció como capellán del ejército en Dover y

María Antonia López Burgos

2003-01-01

2

Incentivos para atraer y retener personal de salud de zonas rurales del Perú: un estudio cualitativo  

PubMed Central

El objetivo fue identificar incentivos de atracción y retención en zonas rurales y distantes de Ayacucho, Perú. Fueron realizadas entrevistas en profundidad con 80 médicos, enfermeras, obstetras y técnicos (20 por grupo) de las zonas más pobres y con 11 funcionarios. No existen políticas sistemáticas de atracción y retención de personal de salud en Ayacucho. Los principales incentivos, en orden de importancia, fueron mejoras salariales, oportunidades de formación y capacitación, estabilidad laboral y nombramiento, mejoras en infraestructura y equipos, e incremento del personal. Se mencionaron también mejoras en la vivienda y alimentación, mayor cercanía con la familia y reconocimiento por el sistema de salud. Existen coincidencias y singularidades entre los distintos grupos sobre los incentivos clave para estimular el trabajo rural, que deben considerarse al diseñar políticas públicas. Las iniciativas del Estado deben comprender procesos rigurosos de monitoreo y evaluación, para asegurar que las mismas tengan el impacto deseado. PMID:22488318

Huicho, Luis; Canseco, Francisco Díez; Lema, Claudia; Miranda, J. Jaime; Lescano, Andrés G.

2014-01-01

3

01/giu/2006 15/ott/2013Localit TUTTI REGIONE DEL SOTTOCONTINENTE: Southern Europe PAESE/ZONA: Italy  

E-print Network

01/giu/2006 15/ott/2013Località TUTTI » REGIONE DEL SOTTOCONTINENTE: Southern Europe » PAESE/ZONA. Milan 4.367 47,17% 2.060 40,33% 3,76 00:02:53 0,00% 0 US$ 0,00 3. Rome 1.648 66,99% 1.104 39,44% 4,58 00:02:51 44,33% 3,16 00:01:53 0,00% 0 US$ 0,00 31. Lecce 87 78,16% 68 37,93% 4,51 00:03:09 0,00% 0 US$ 0,00 32

Robbiano, Lorenzo

4

USO DEL ANÁLISIS DIGITAL DE IMÁGENES PARA EL ESTUDIO DE LA POROSIDAD DE LA ZONA NO SATURADA DE ARGIUDOLES DE ARGENTINA  

Microsoft Academic Search

RESUMEN. El flujo de agua y solutos en la zona no saturada está fuertemente influido por la macroporosidad del suelo, la cual puede ser evaluada y cuantificada a partir de técnicas micromorfológicas y el análisis de imágenes. Se determinó la superficie ocupada por distintas formas y tamaños de poros mayores a los 50 µm de tres Argiudoles de Argentina, diferenciados

M. G. Castiglioni; H. J. M. Morrás

5

Estudios en la Zona no Saturada del Suelo. Vol X ALGORITMO MECANSTICO SIMPLIFICADO PARA LA CUANTIFICACIN DEL EFECTO DE UN  

E-print Network

encharcamiento del suelo y balance de agua durante un hietograma de lluvia natural. El modelo se contrasta se estudia la extensión de la ecuación de Green-Ampt para la infiltración de agua en presencia de un nivel freático somero estable bajo condiciones de lluvia natural, y su efecto sobre la redistribución de

Boyer, Edmond

6

Zona Land: Wave Adder  

NSDL National Science Digital Library

This item is an interactive Java simulation that models the addition and subtraction of waves. You can set amplitude, frequency, and phase shift of two waves, then push the "Add" button to see the wave addition on a coordinate plane. The student may select either addition or subtraction and may opt for either sine or cosine functions. These buttons are at the lower left (their text is hard to see). SEE RELATED ITEMS ON THIS PAGE for a link to the full set of Zona Land Waves tutorials.

Zobel, Edward

2009-03-22

7

¿ELECTRIFICACIÓN O ENERGIZACIÓN? MEDIANTE ENERGÍAS ALTERNATIVAS EN ZONAS RURALES 1  

Microsoft Academic Search

RESUMEN . Pasó más de una década del inicio de proyectos of iciales, relacionados básicamente con el suministro de energía eléctrica para zonas rurales en Argentina. El Gobierno Nacional, los Provinciales, ONGs e incl usive algunas empresas particulares, realizaron en los últimos ve inticinco años (para ciertos casos) diversos intent os poniendo en funcionamiento proyectos demostrativos, sistemas concesionados, o bien

Carlos Cadena; Facultad de Ciencias Exactas

2006-01-01

8

Inhibitory effect of homologous solubilized zona pellucida  

E-print Network

(275-165) kd, 100 (135-96) kd and 75 (96-51 ) kd. Preincubation of sperm with heat-solubilized zonaeInhibitory effect of homologous solubilized zona pellucida on rabbit in vitro fertilization Martine zonae pellucidae were isolated using a modified technique of Dunbar et al (1980). Zonae pellucidae were

Paris-Sud XI, Université de

9

Los riesgos de la contaminacin atmosfrica en zonas Laboratorio de Especiacin Qumica de Aerosoles Orgnicos Atmosfricos y  

E-print Network

Los riesgos de la contaminación atmosférica en zonas urbanas Laboratorio de Especiación Química de del aire de la Zona Metropolitana del Valle de México 2011-2020. #12;Indice Metropolitano de la Calidad del Aire (IMECA) IMECA CONDICION EFECTOS EN SALUD 0-50 Buena Ninguno 51-100 Regular Molestias en

Grutter, Michel

10

Characterization of human zona pellucida glycoproteins  

Microsoft Academic Search

5To whom correspondence should be addressed The human egg may only be fertilized by one spermatozoon to prevent polyploidy. In most mammals, the primary block to polyspermy occurs at the zona pellucida (ZP). Little is known of the human ZP and the changes occurring following fertilization to prevent polyploidy. Using antibodies directed against synthetic peptides predicted from the human ZP2

Asne R. Bauskin; Daniel R. Franken; Uwe Eberspaecher; Peter Donner

1999-01-01

11

Necessity of adjuvants for inducing effective antibody response to zona pellucida antigens  

Microsoft Academic Search

Summary Rhesus monkeys evoked a vigorous antibody response to a single heteroimmunization dose of zona pellucida antigens, when these were administered along with complete Freud's adjuvant. The antisera recognized all the three major porcine zona glycoprotein families and the animals were rendered amenorrheic after such immunization. Monkeys immunized with zona without adjuvant, however, failed to show any anti-zona antibody response

P. Bhatnagar; S. Sehgal; S. K. Gupta; B. S. Dunbar

1989-01-01

12

MTODO DE CENSO Y ESTIMA DE POBLACIN DEL PINZN AZUL DE GRAN CANARIA  

E-print Network

, Ojeda y Pajonales, donde alcanza una densidad media de 3,51 pinzones / km2 . El grueso de la población se localiza en esta zona en el sector norte, y en el sur por encima de los 1.150 m de altitud, que heterogeneidad espacial del reparto de la abundancia de la especie dentro de esta zona. Se recomienda cautela

Carrascal, Luis M.

13

Laser zona dissection using short-pulse ultraviolet lasers  

NASA Astrophysics Data System (ADS)

The interaction of pulsed ultraviolet radiation with the zona pellucida of human oocytes which had failed to fertilize in standard IVF cycles, was investigated. Two lasers were studied: a 100 ps pulsed Nd:YAG with a nonlinear crystal emitting light at 266 nm, and a 15 ns XeCl excimer laser with 308 nm radiation. Incisions in the zona were made by aiming the beam tangentially to the oocyte. The results indicate superior, high precision performance by the excimer laser creating trenches as narrow as 1 micrometers and as shallow as 1 micrometers . The incision size was found to be sensitive to the laser's energy and to the position of the microscope's objective focal plane, but relatively insensitive to the laser pulse repetition rate. Once the minimum spot size was defined by the system parameters, the laser beam was used to curve out any desired zona shape. This laser microsurgery technique as applied to partial zone dissection or zona drilling could prove very useful as a high-precision, non-contact method for treatments of low fertilization rate and for enhancing embryo implantation rates in patients undergoing IVF treatments.

Neev, Joseph; Tadir, Yona; Ho, Peter D.; Whalen, William E.; Asch, Richardo H.; Ord, Teri; Berns, Michael W.

1992-06-01

14

Memorias del Segundo Simposio Internacional Sobre Polticas, Planificacin y Economa de los Programas de Proteccin Contra Incendios Forestales: Una Visin Global Memorias del Segundo Simposio Internacional Sobre Polticas, Planificacin y Economa de los Progra  

E-print Network

Programas de Protección Contra Incendios Forestales: Una Visión Global 51 Memorias del Segundo Simposio producen los incendios forestales en determinadas zonas, y las grandes dimensiones que en ocasiones. Un estudio de lo sucedido en zonas anteriormente quemadas puede ser interesante como instrumento de

Standiford, Richard B.

15

Role of zona pellucida glycoproteins during fertilization in humans.  

PubMed

In the last decade, scientific investigations pertaining to the role of zona pellucida (ZP) glycoproteins during fertilization in humans have led to new insights. This has been achieved using purified native/recombinant human zona proteins and transgenic mice expressing human ZP glycoproteins. The proposed model in mice of ZP glycoprotein-3 (ZP3) acting as primary sperm receptor and ZP glycoprotein-2 (ZP2) as secondary sperm receptor has been modified for sperm-egg binding in humans. ZP glycoprotein-1 (ZP1), ZP3, and ZP glycoprotein-4 (ZP4) have been shown to bind to the capacitated human sperm. ZP2 binds to the acrosome-reacted human spermatozoa. Further, the eggs obtained from transgenic mice expressing human ZP2 alone or in conjunction with other human instead of mouse zona proteins showed binding of human sperm, suggesting that ZP2 might also play a role in sperm-egg binding. This function has been mapped to a domain corresponding to amino acid residues 51-144 of ZP2. In contrast to mice, where ZP3 is the primary agonist for inducing the acrosome reaction, in humans, the acrosome reaction can be mediated by ZP1, ZP3, and ZP4. The effect of mutations in the genes encoding zona proteins on the ZP morphology and infertility has not been established. Further, the role of autoantibodies against ZP in women with 'unexplained infertility' leading to poor outcome of in vitro fertilization is currently controversial and needs further investigations. Understanding the role of ZP glycoproteins during human fertilization facilitates the development of new contraceptives and strategies to overcome the problem of infertility. PMID:25445843

Gupta, Satish Kumar

2014-10-01

16

Contraceptive potential of porcine zona pellucida in cats  

Microsoft Academic Search

The contraceptive potential of solubilized porcine zona pellucida (spZP) was studied in 2 groups of cats after active immunization using slightly different protocols. Cats from Group 1 (n = 3) were immunized with a total of 300 8g spZP divided in 4 sc multisite injections (each of 37.5 8g) given at 10 day intervals followed by a booster 150 days

M. Ivanovo; M. Petrov; D. Klissourska; M. Mollova

1995-01-01

17

In vitro fertilization rate of horse oocytes with partially removed zonae.  

PubMed

Frozen-thawed ejaculated stallion spermatozoa were preincubated for 3 h in BO medium containing 5 mM caffeine and then treated with 0.1 micro M calcium ionophore A23187 for 60 sec. Aliquots of the sperm suspension (final concentration 1-2 x 10(7)/ml) were added to the oocytes which had been matured in vitro for 32 h. In Experiment 1, there were 3 groups of oocytes; cumulus intact, denuded zona-intact, and zona-free. Cumulus cells were removed with 0.5% hyaluronidase and the zona pellucida with 0.1% protease. The oocytes were fixed 20 h after insemination with acetic acid:ethanol (1:3) and stained with 1% orcein. The sperm penetration rate of zona-free oocytes was 83%, whereas the sperm penetration rate was very low (1 to 3%) in the cumulus-enclosed or zona-intact oocytes. In Experiment 2, denuded zona-intact oocytes were placed in PBS supplemented with 10% fetal bovine serum 1 h before the end of in vitro maturation. The zona pellucida was micromanipulated with a metal microblade under x 100 magnification within 20 min of treatment with 0.3 M sucrose. For partial zona dissection, a slit in the zona pellucida was made. For partial zona removal, oocytes were transferred to protein-free PBS to fix the oocytes on the bottom of the Petri-dish and to remove a piece of the zona pellucida. Micromanipulated oocytes were subjected to in vitro fertilization as described above. Zona-intact and zona-free oocytes treated with sucrose solution for 20 min were used as controls. The penetration rates were 4 (2/57), 12 (7/58), 52 (31/60), and 86% (44/51) for zona-intact, partially zona dissected, partially zona removed, and zona-free oocytes, respectively. Proportions of oocytes with monospermic penetration were 100 (2/2), 57 (4/7), 58 (18/31), and 34% (15/44), respectively. In Experiment 3, sperm penetration and male pronucleus formation in the partially zona removed oocytes were examined at 2.5 to 20.0 h of insemination. Sperm penetration started 2.5 h post-insemination (22%, 11/49), and increased to 38% (21/55) at 5 h, to 46% (23/50) at 10 h, and to 56% (27/48) at 20 h. The transformation of sperm heads into male pronuclei was first observed 10 h post insemination. These results indicate that assisted fertilization techniques may be a useful tool for achieving fertilization and embryo production in vitro in horses. PMID:16727585

Choi, Y H; Okada, Y; Hochi, S; Braun, J; Sato, K; Oguri, N

1994-10-01

18

Viscous forces are predominant in the zona pellucida mechanical resistance  

NASA Astrophysics Data System (ADS)

The zona pellucida (ZP) is a multilayer glycoprotein spherical shell surrounding mammalian eggs. The ZP's mechanical response plays a crucial role in mammalian fertilization and is a parameter commonly adopted in "in vitro fertilization" to characterize the oocytes quality. While it is assumed that ZP mechanical response is purely elastic, here we prove that dissipative forces cannot be neglected. Physiologically, this evidence implies that an increase in the spermatozoa motility can induce dramatic changes on the ZP reaction force turning ZP shell in an impenetrable barrier leading to fertility impairments.

Papi, Massimiliano; Maiorana, Alessandro; Douet, Cécile; Maulucci, Giuseppe; Parasassi, Tiziana; Brunelli, Roberto; Goudet, Ghylène; De Spirito, Marco

2013-01-01

19

Sobre la Universidad UMASS Amherst es el recinto principal del sistema de la Universidad  

E-print Network

Massachusetts. La universidad está ubicada en el oeste de Massa- chusetts en una de las zonas más seguras y universidad no sólo tiene uno de los mejores centros de recreación del país, también la pintoresca zona de-70 Mejores Universidades por reputación #55 Artes y Humanidades #50 Clínicos/preclínicos y Salud #51 Ciencias

Mountziaris, T. J.

20

Nanoscale characterization of the biomechanical hardening of bovine zona pellucida  

PubMed Central

The zona pellucida (ZP) is an extracellular membrane surrounding mammalian oocytes. The so-called zona hardening plays a key role in fertilization process, as it blocks polyspermy, which may also be caused by an increase in the mechanical stiffness of the ZP membrane. However, structural reorganization mechanisms leading to ZP's biomechanical hardening are not fully understood yet. Furthermore, a correct estimate of the elastic properties of the ZP is still lacking. Therefore, the aim of the present study was to investigate the biomechanical behaviour of ZP membranes extracted from mature and fertilized bovine oocytes to better understand the mechanisms involved in the structural reorganization of the ZP that may lead to the biomechanical hardening of the ZP. For that purpose, a hybrid procedure is developed by combining atomic force microscopy nanoindentation measurements, nonlinear finite element analysis and nonlinear optimization. The proposed approach allows us to determine the biomechanical properties of the ZP more realistically than the classical analysis based on Hertz's contact theory, as it accounts for the nonlinearity of finite indentation process, hyperelastic behaviour and material heterogeneity. Experimental results show the presence of significant biomechanical hardening induced by the fertilization process. By comparing various hyperelastic constitutive models, it is found that the Arruda–Boyce eight-chain model best describes the biomechanical response of the ZP. Fertilization leads to an increase in the degree of heterogeneity of membrane elastic properties. The Young modulus changes sharply within a superficial layer whose thickness is related to the characteristic distance between cross-links in the ZP filamentous network. These findings support the hypothesis that biomechanical hardening of bovine ZP is caused by an increase in the number of inter-filaments cross-links whose density should be higher in the ZP inner side. PMID:22675161

Boccaccio, Antonio; Frassanito, Maria Cristina; Lamberti, Luciano; Brunelli, Roberto; Maulucci, Giuseppe; Monaci, Maurizio; Papi, Massimiliano; Pappalettere, Carmine; Parasassi, Tiziana; Sylla, Lakamy; Ursini, Fulvio; De Spirito, Marco

2012-01-01

21

ESTUDIO ESPACIO-TEMPORAL DEL CONSUMO DE HIGOS  

Microsoft Academic Search

El higo (Ficus carica, L), es un sicona dc una influorescencia, repleto de granos o flores fecundadas, recubierto de una piel fina de color y aspecto variables. Se origina de un arbusto de la familia de las Moráceas, especie Ficus carica, cuyo cultivo está muy extendido en el Mediterráneo y en zonas cálidas. El consumo del higo es muy apreciado

M. C. Gallego; R. Angulo; S. Serrano; M. Jodral

1996-01-01

22

Heterogeneity of the zona pellucida carbohydrate distribution in human oocytes failing to fertilize in vitro.  

PubMed

The mammalian zona pellucida contains several glycoproteins whose oligosaccharide moieties are known to play a key role in the interaction with spermatozoa. Since zona pellucida defects may represent one of the most likely causes of failed fertilization in human in-vitro reproduction, we have studied the carbohydrate composition and distribution over the human zona pellucida by means of lectins. Donated, not inseminated cumulus-oocyte complexes, from cohorts with high fertilization rates, and fertilization-failed oocytes from cohorts inseminated with proven fertile donor semen, were analysed using 11 fluorescein-labelled lectins, on deplasticized semi-thin epoxy sections. Results showed that wheat germ agglutinin (WGA), Maclura pomifera (MPA) and Pisum sativum (PSA) bound to the extracellular matrix bordering the zona pellucida-corona radiata interface of cumulus-oocytes complexes, while the zona pellucida was labelled by WGA, Concanavalin A (ConA) and PSA. WGA labelling and correlative electron microscopy on the cumulus-oocyte complexes demonstrated that this lectin is a useful tool to trace the cortical granule distribution in the human oocyte. Surprisingly, in the failed-fertilized oocytes the zona pellucida was also labelled by MPA and showed three different patterns: (i) labelling of the zona pellucida outer surface; (ii) uniform labelling; (iii) labelling of an outer zona pellucida layer with variable thickness. Comparative analysis of WGA and MPA labelling on single failed-fertilized oocytes demonstrated that MPA zona pellucida patterns are not related to the cortical reaction. The nature and meaning of the MPA pattern of failed-fertilized oocytes were discussed in the light of zona pellucida defects impairing sperm receptivity. PMID:9455851

Talevi, R; Gualtieri, R; Tartaglione, G; Fortunato, A

1997-12-01

23

L’eruzione laterale etnea del novembre 1950 — dicembre 1951  

Microsoft Academic Search

Conclusione  L’eruzione etnea del 1950–51 si manifestata quasi senza segni premonitori, dopo una breve (meno di un anno) stasi del vulcano.\\u000a Essa si stabilita in una zona che stata gi teatro di precedenti eruzioni (1811) ed ha avuto un’attivit prevalentemente\\u000a effusiva di notevole durata. La lava emessa ha la composizione mineralogica identica alle lave emesse in questo secolo; essa\\u000a si differenzia

Gustavo Cumin

1954-01-01

24

The paradoxical effects of pentoxifylline on the binding of spermatozoa to the human zona pellucida.  

PubMed

In the presence of pentoxifylline, human spermatozoa are induced to increase certain motion characteristics; however, the role of this drug in fertilization remains equivocal. In this study, the influence of pentoxifylline on one aspect of fertilization, that is sperm-zona binding, has been examined. Results from a fluorescence label competitive zona binding (CZB) test showed that spermatozoa exposed to a pentoxifylline challenge of between 0.1 and 5 mM, which was curtailed after 1 h by washing, had a decreased (P < 0.01) ability to bind to intact zona compared with control spermatozoa. The washing procedures also removed (decrease P < 0.01 compared with peak values) some of the enhanced motion characteristics induced by pentoxifylline. These results were in contrast with those obtained using experimental conditions that maintained an increased curvilinear velocity (VCL) and lateral head displacement (ALH) (increase P < 0.001 above baseline controls) in the continued presence of pentoxifylline. Using a hemizona binding (HZB) assay, 3 mM pentoxifylline increased (P < 0.001) sperm-zona binding almost 20% above zona binding with unexposed control spermatozoa. It was concluded that, in the presence of pentoxifylline, there is increased sperm binding to the zona pellucida; however, if the drug is removed by washing, the sperm binding to the zona is decreased in concert with the removal of the enhanced motion characteristics. The application of zona solubilization by acidic conditions in a microchamber enabled the precise determination of sperm numbers in both of the sperm-zona binding assays, and the results demonstrated that a wide variation in sperm numbers was observed in each test, with 63-580 spermatozoa bound in the CZB assay and 56-1340 spermatozoa bound on a hemizona. PMID:8671333

Paul, M; Sumpter, J P; Lindsay, K S

1996-04-01

25

VALIDACIÓN DE GENOTIPOS DE FRIJOL NEGRO EN LA ZONA CENTRAL DEL ESTADO DE VERACRUZ, MEXICO1  

Microsoft Academic Search

Validation of genotypes of black bean in the central area of the state of Veracruz, Mexico. The aims of this work was to validate bean growers' fields. During 1998 to 2001 residual moisture growing cycles, nine validation plots were established. The bean genotypes utilized were: the lines II-307 and DOR-500 and the varieties Negro Huasteco 81, Negro Cotaxtla 91, Negro

Francisco Javier Ugalde Acosta; Ernesto López Salinas; Oscar Hugo; Tosquy Valle

26

VALIDACIÓN DE GENOTIPOS DE FRIJOL NEGRO EN LA ZONA CENTRAL DEL ESTADO DE VERACRUZ, MEXICO 1  

Microsoft Academic Search

Validation of genotypes of black bean in the central area of the state of Veracruz, Mexico. The aims of this work was to validate bean growers' fields. During 1998 to 2001 residual moisture growing cycles, nine validation plots were established. The bean genotypes utilized were: the lines II-307 and DOR-500 and the varieties Negro Huasteco 81, Negro Cotaxtla 91, Negro

Francisco Javier Ugalde Acosta; Ernesto López Salinas; Oscar Hugo; Tosquy Valle

2005-01-01

27

Welcome to Zona Land: Education in Physics and Mathematic  

NSDL National Science Digital Library

Zona Land, created by Ed Zobel, is a science and mathematics resource site for students and teachers. The site illustrates mathematical and physical principles by the use of Java applets and VRML simulations. The Science section contains the Physics Department (mechanics, waves and light), EZ Graph, and EZ Evaluator. EZ Graph allows the user to view the graph of a desired function. Evaluator is an online calculator that has trigonometric capabilities. The Mathematics section has four subject areas plus the Graph and Evaluator tools. Graph Paper allows the user to examine the effects of different scales on pre-designed linear, cubic, quadratic, and sine functions. The Function Institute begins with an optional tour of the definition of a function. Also available at the Institute are graphs of linear and polynomial functions. The Geometry Section has three areas of resources: Common Shapes, Fractals, and Coordinate Geometry. Trigonometry Realms has a simple yet comprehensive introduction to trigonometry. Help is available for all of the different resource applications.

Zobel, Edward A.

1998-01-01

28

Rusco aculeati-Fraxinetum angustifoliae, una nova associació forestal de ribera del territori ruscínic  

Microsoft Academic Search

Proposem una nova comunitat de ribera del territori ruscínic, dominada per Fraxinus angustifolia, que ocupa, d’una banda, la zona marginal externa de les alberedes litorals (Populetum albae), i d’altra, els petits cursos d’aigües estacionals de l’interior. Aquesta comunitat s’estableix en sòls amb marcades oscil·lacions estacionals del nivell freàtic, cosa que afavoreix precisament l a instal·lació dels freixes de fulla petita,

Josep Gesti Perich; Lluís Vilar Saís

2003-01-01

29

1. Aprovaci de l'acta de la sessi anterior 2. Informe del president  

E-print Network

dels pressupost 2011 de despeses de l'Institut de Sostenibilitat CS 13/07 2011 51/2011 132/2011 4 subsòl de la zona verda del Campus Interuniversitari del Besòs CS 16/07 2011 54/2011 136/2011 4, de les proposes que es formulin 5.1. Punts informatius 5.1.1. Indicadors de l'activitat de recerca i

Politècnica de Catalunya, Universitat

30

EL TURISMO RURAL EN SUR DE ESPAÑA ANÁLISIS DE LA SATISFACCIÓN DEL TURISTA EN UN PARQUE NATURAL  

Microsoft Academic Search

En los últimos años se viene observando un cambio en los gustos del consumidor turístico, con la aparición de un nuevo tipo de turismo postfordista o a la carta en donde el cliente participa en la organización del mismo. Este es un enfoque al que se pueden adaptar especialmente bien las zonas rurales, pues están diseñadas para que en ellas

Genoveva Millán Vázquez de la Torre; Emilio Morales Fernández; María Sol Castro Freire

2011-01-01

31

Effects of xenoestrogen treatment on zona radiata protein and vitellogenin expression in Atlantic salmon ( Salmo salar)  

Microsoft Academic Search

Zonagenesis (zona radiata protein synthesis) and vitellogenesis (yolk protein synthesis) are two reproductive responses that are integral aspects of fish oogenesis. This study examines the responses of eggshell zona radiata proteins (Zrp) and vitellogenin (Vtg) to five environmental pollutants; 4-nonylphenol (NP) and o,p?-DDT [both at 25 mg\\/kg], lindane (?-HCH) [10 mg\\/kg], a technical PCB mixture (Aroclor 1254; A1254) and bisphenol

Augustine Arukwe; Trine Celius; Bernt T Walther; Anders Goksøyr

2000-01-01

32

Loss of Zona Pellucida Binding Proteins in the Acrosomal Matrix Disrupts Acrosome Biogenesis and Sperm Morphogenesis  

Microsoft Academic Search

Zona pellucida binding protein 1 (ZPBP1), a spermatid and spermatozoon protein that localizes to the acrosome, was originally identified in pigs and named for its binding to the oocyte zona pellucida. In an in silico search for germ cell-specific genes, Zpbp1 and its novel paralog, Zpbp2, were discovered and confirmed to be expressed only in the testes in both mice

Yi-Nan Lin; Angshumoy Roy; Wei Yan; Kathleen H. Burns; Martin M. Matzuk

2007-01-01

33

Amino Acid Sequences of Porcine Sp38 and Proacrosin Required for Binding to the Zona Pellucida  

Microsoft Academic Search

We previously purified a boar sperm protein, sp38, and demonstrated that this protein bound to the 90-kDa family of zona pellucida (ZP) glycoprotein in a calcium-dependent manner. Sp38 competed with proacrosin for the binding to the zona pellucida. Herein we have isolated cDNA clones encoding sp38 from a boar testis cDNA library in ?gt11. The amino acid sequence deduced from

Etsuko Mori; Shin-ichi Kashiwabara; Tadashi Baba; Yoshimasa Inagaki; Tsuneatsu Mori

1995-01-01

34

Oocyte zona birefringence intensity is associated with embryonic implantation potential in ICSI cycles.  

PubMed

A retrospective study recently showed that oocytes presenting with a high birefringence of the inner zona layer were more often associated with conception cycles. To further investigate these findings, a prospective study was conducted between September 2005 and September 2006 including intracytoplasmic sperm injection (ICSI) cycles presenting with at least two embryos for transfer. Using a polarization imaging system, oocytes were classified prior to ICSI treatment as having either a high zona birefringence (HZB) or a low zona birefringence (LZB) of the zona pellucida. Using zona birefringence as the only selection criterion, two fertilized oocytes, preferably derived from HZB oocytes, were selected for further culture and transfer. The required criteria were met by 135 ICSI cycles (124 patients; 34.9 +/- 4.1 years of age). Embryos for transfer were used in 20 cycles derived from HZB/HZB oocytes, in 50 cycles from HZB/LZB oocytes and in 65 from LZB/LZB oocytes. The corresponding implantation (P < 0.025), pregnancy (P < 0.005) and live birth (P < 0.025) rates were significantly different between HZB/HZB and HZB/LZB versus LZB/LZB group. Embryo development was superior in embryos derived from HZB oocytes. This study concludes that oocyte zona birefringence is a good selection criterion and a good predictive criterion for embryo implantation potential. PMID:18284880

Montag, M; Schimming, T; Köster, M; Zhou, C; Dorn, C; Rösing, B; van der Ven, H; Ven der Ven, K

2008-02-01

35

Sodium deficiency regulates rat adrenal zona glomerulosa gene expression.  

PubMed

Aldosterone is the primary adrenocortical hormone regulating sodium retention, and its production is under the control of the renin-angiotensin-aldosterone system (RAAS). In vitro, angiotensin II can induce aldosterone production in adrenocortical cells without causing cell proliferation. In vivo, a low-sodium diet activates the RAAS and aldosterone production, at least in part, through an expansion of the adrenal zona glomerulosa (zG) layer. Although these mechanisms have been investigated, RAAS effects on zG gene expression have not been fully elucidated. In this study, we took an unbiased approach to define the complete list of zG transcripts involved in RAAS activation. Adrenal glands were collected from 11-week old Sprague-Dawley rats fed either sodium-deficient (SDef), normal sodium (NS), or high-sodium (HS) diet for 72 hours, and laser-captured zG RNA was analyzed on microarrays containing 27 342 probe sets. When the SDef transcriptome was compared with NS transcriptome (SDef/NS comparison), only 79 and 10 probe sets were found to be up- and down-regulated more than two-fold in SDef, respectively. In SDef/HS comparison, 201 and 68 probe sets were up- and down-regulated in SDef, respectively. Upon gene ontology (GO) analysis of these gene sets, we identified three groups of functionally related GO terms: cell proliferation-associated (group 1), response to stimulus-associated (group 2), and cholesterol/steroid metabolism-associated (group 3) GO terms. Although genes in group 1 may play a critical role in zG layer expansion, those in groups 2 and 3 may have important functions in aldosterone production, and further investigations on these genes are warranted. PMID:24422541

Nishimoto, Koshiro; Harris, Ruth B S; Rainey, William E; Seki, Tsugio

2014-04-01

36

ZONA PELLUCIDA: AN EXTRACELLULAR MATRIX WITH APPLICATIONS IN THE STUDY OF IMMUNOCONTRACEPTION IN DOMESTIC CARNIVORES Zona Pelúcida: Una Matriz Extracelular con Aplicaciones en Anticoncepción de Carnívoros Domésticos  

Microsoft Academic Search

Zona pellucida (ZP) is an extracellular matrix surrounding the mammalian oocyte. In most mammalian species this matrix consists of three families of glycoproteins likely to suffer several postraductional modifications to acquire different immunological and biochemical properties. The ZP are involved in the initial recognition and binding events of sperm to oocyte investments. Because of its major role in the fertilization

Alfonso Sánchez Riquelme; Avenida Agua Santa

2004-01-01

37

PREVALENCIA Y FACTORES ASOCIADOS AL ASMA EN NIÑOS DE 5 A 14 AÑOS DE UN ÁREA RURAL DEL SUR DEL PERÚ  

Microsoft Academic Search

RESUMEN Objetivos. Determinar la prevalencia y los factores asociados al asma en niños de 5 a 14 años de una zona rural en la provincia de Ica, Perú. Materiales y métodos. Se realizó un estudio transversal en niños de 5 a 14 años del distrito de Santiago, Ica, en el año 2004. Se visitaron a las madres de los niños

César V. Munayco; Jesús Arana; Julio Torres-Chang; Luis Saravia; M. Gabriela Soto-Cabezas

2009-01-01

38

Inhibition of human spermatozoa–zona pellucida binding by a combinatorially derived peptide from a synthetic target  

Microsoft Academic Search

Intact zona-free human oocytes were screened using a combinatorial peptide library selection protocol. Pieczenik Peptide Sequence 1 (PPS1) HEHRKRG binds human spermatozoa. A complementary and unique binding sequence HNSSLSPLATPA (PPS2) was developed from the first PPS1 ligand that binds to the human zona pellucida or oolemma. Cytoplasm-free zonae from unfertilized eggs were obtained and used as an assay system to

George Pieczenik; John Garrisi; Jacques Cohen

2006-01-01

39

AMRICA LATINA -AFRICA -ASIA -MEDITERRNEO -ULTRAMAR TROPICAL FRANCS s En los pases del Sur 36  

E-print Network

información 50 s La evaluación 51 s La deontología y la ética 52 Recursos y pilotaje del instituto s El en el conjunto de la zona intertropical, el IRD cumple tres misiones fundamentales: inves- tigación

40

PERFIL SOCIOECONÓMICO DEL ADULTO MAYOR EN EL MUNICIPIO DE SAN LUIS POTOSÍ  

Microsoft Academic Search

Conocer el perfil socioeconómico del adulto mayor (AM) en el municipio de San Luis Potosí. Metodología: Estudio descriptivo, realizado con 652 adultos mayores registrados en DIF Municipal de tres zonas delegacionales y parte de la cabecera municipal de San Luis Potosí, S.L.P, seleccionados por muestreo probabilístico aleatorio simple. Los resultados corresponden a los indicadores situación social y económica conformada con

Rosa Ma. Guadalupe Andrade-Cepeda

2010-01-01

41

Ultrastructural localization of lectin-binding sites on the zonae pellucidae and plasma membranes of mammalian eggs  

Microsoft Academic Search

Receptors for Ricinus communis agglutinin I (RCAt), concanavalin A (Con A), and wheat germ agglutinin (WGA) were localized on the zonae pellucidae and plasma membranes of hamster, mouse, and rat eggs with ferritin-lectin conjugates. Intact eggs labeled with the ferritin conjugates showed dense concentrations of RCA~ and WGA receptors in the outermost regions of their zonae pellucidae and sparse distributions

GARTH L. NICOLSON; RYUZO YANAGIMACHI; HIROKO YANAGIMACHI

1975-01-01

42

Surface alterations of the mouse zona pellucida and ovum following in vivo fertilization: correlation with the cell cycle  

Microsoft Academic Search

The zona pellucida and cell surface of in vivo fertilized mouse ova exhibit time dependent changes which can be detected with the scanning electron microscope. The periods of ovulation, fertilization and first cleavage in superovulated C3D2\\/F⁠hybrids were determined and times corresponding to Gâ, S, Gâ, and M were calculated. The zona of a mature unfertilized ovum has a rough

S. Jackowski; J. N. Dumont

1979-01-01

43

Effect of IVF and laser zona dissection on DNA methylation pattern of mouse zygotes  

E-print Network

2009 Ã? Springer Science+Business Media, LLC 2009 Abstract In vitro fertilization (IVF) and zona fertilized in vitro with freshly collected spermatozoa. Zygotes were fixed 5, 8, and 12 h after fertilization spermatozoa and in vitro fertilization or thawed embryos and embryo transfer (Marschall et al. 1999). In vitro

Rodenacker, Karsten

44

La Zona Franca y su caos DesirDesir GmezGmez TorrentTorrent  

E-print Network

La Zona Franca y su caos DesiréDesiré GàmezGàmez TorrentTorrent #12;ESTRUCTURAESTRUCTURA 1. Conclusiones4. Conclusiones #12;¿Cual es el sustrato?¿Cual es el sustrato? Linea 9: Foneria de 48-51 m

Politècnica de Catalunya, Universitat

45

El uso de la neuromodulación para el tratamiento del temblor  

PubMed Central

Introducción: El temblor puede ser un desorden incapacitante y el tratamiento de primera línea para estos pacientes es farmacológico. Sin embargo, este tratamiento puede llevar a una reducción satisfactoria del temblor en sólo el 50% de los pacientes con temblor esencial. La talamotomía era el tratamiento de elección para el temblor refractario al tratamiento médico hasta que comenzó a utilizarse la estimulación cerebral profunda (ECP) del núcleo ventral intermedio (Vim) del tálamo. En la actualidad, raramente se realiza la talamotomía. Métodos: Este artículo es una revisión no sistemática de las indicaciones, resultados, parámetros de programación y técnica quirúrgica de la ECP del Vim para el tratamiento del temblor. Resultados: Aunque los resultados clínicos son similares usando la talamotomía o la ECP del Vim, la primera causa más efectos adversos que la última. Además, la ECP puede ser usada bilateralmente, mientras que la talamotomía tiene un alto riesgo de causar disartria cuando se realiza de ambos lados. La ECP del Vim logró una adecuada mejoría del temblor en varias series de pacientes con temblor causado por temblor esencial, enfermedad de Parkinson o esclerosis múltiple. Además del Vim, hay otros blancos que están siendo usados por varios autores, tales como la zona incerta y las radiaciones prelemniscales. Conclusión: La ECP del Vim es un tratamiento útil para el temblor incapacitante refractario al tratamiento médico. Es esencial realizar una precisa selección de pacientes, así como utilizar una técnica quirúrgica correcta. Aún se desconoce el mejor blanco estereotáctico para el temblor, aunque el Vim es el más usado. PMID:25165613

Bendersky, Damián; Ajler, Pablo; Yampolsky, Claudio

2014-01-01

46

Retinal projections into the Zona Incerta of the rock cavy (Kerodon rupestris): a CTb study.  

PubMed

The Zona Incerta is a key neural substrate of higher brain functions. A neural population in the caudal ZI projects into the superior colliculus. This recently has been identified as an important structure for the saccades. Applying CTb, we describe a retinal projection into the caudal ZI and the distribution of its terminal varicosities in the rock cavy, a Brazilian rodent, which has been used as an anatomical model to enhance the comprehension about the phylogeny of the nervous system. Contrary to other investigated rodents, the retinal fibers in the rock cavy lie in the caudal Zona Incerta (ZIc), suggesting a functional specialization in the rock cavy. The high resolution and qualitative analysis of retinal fibers in the present work provide a substrate to interpretation of the visual system, and its phylogenetic pathways among species. PMID:25242576

de Góis Morais, Paulo Leonardo Araújo; de Santana, Melquisedec Abiaré Dantas; Cavalcante, Judney Cley; de Oliveira Costa, Miriam Stela Maris; Sousa Cavalcante, Jeferson; do Nascimento, Expedito Silva

2014-12-01

47

Zona Pellucida Induces Activation of Phospholipase A2 During Acrosomal Exocytosis in Guinea Pig Spermatozoa1  

Microsoft Academic Search

Phospholipase A2 (PLA2) is activated in spermatozoa in re- sponse to progesterone and Ca 21 ionophores, but to our knowl- edge, no study has yet reported zona pellucida (ZP)-induced activation of PLA2. We investigated whether PLA2 is involved in ZP-stimulated acrosomal exocytosis, if Ca 21 is required for ac- tivation of PLA2, and signal transduction pathways modulating PLA2 using guinea

Y. Y. Yuan; W. Y. Chen; Q. X. Shi; L. Z. Mao; S. Q. Yu; X. Fang; E. R. S. Roldan

48

Two subunits of the 55 K porcine zona pellucida glycoprotein family are immunologically distinct  

Microsoft Academic Search

The 55K glycoprotein family (ZP3) of the porcine zona pellucida is comprised of two subunits of 46 K and 45 K which can be resolved by endo-..beta..-galactosidase digestion of ZP3 followed by reversed phase HPLC on Vydac C4 resin. Gel electrophoresis revealed that the 46 K component (EBDG..cap alpha..) is approx. 95% pure and the 45 K component (EBGD..beta..) is

M. G. Subramanian; E. C. Yurewicz; A. G. Sacco

1986-01-01

49

Body mass index is not associated with sperm–zona pellucida binding ability in subfertile males  

PubMed Central

Lifestyle factors, such as weight and nutritional status may affect male fertility, including sperm fertilization ability. The objective of this retrospective study was to evaluate the association between body mass index (BMI) and sperm–zona pellucida binding ability assessed according to the zona binding (ZB) test, which has been described to be a relevant diagnostic tool for the prediction of in vitro fertilization (IVF) ability. Three hundred and six male patients from couples diagnosed with primary idiopathic or mild male factor infertility were included. Correlations between BMI and semen parameters according to ZB test indices were assessed, together with frequencies of positive and negative tests across the BMI categories. In this selected population, BMI was not related to conventional semen parameters or sperm quality assessed according to the ability of spermatozoa to bind to the zona pellucida. The previously described poor outcomes of IVF procedures in cases of male obesity could be due to other sperm defects, such as alterations of sperm capacitation or acrosome reaction. The link between male BMI and biological outcomes during IVF procedures, such as fertilization rates, should be further evaluated. PMID:23770940

Sermondade, Nathalie; Dupont, Charlotte; Faure, Céline; Boubaya, Marouane; Cédrin-Durnerin, Isabelle; Chavatte-Palmer, Pascale; Sifer, Christophe; Lévy, Rachel

2013-01-01

50

Developmental competence of equine oocytes: impacts of zona pellucida birefringence and maternally derived transcript expression.  

PubMed

In the present study, equine oocytes were classified into groups of presumably high and low developmental competence according to cumulus morphology, as well as oocyte ability to metabolise brilliant cresyl blue (BCB) stain. All oocytes were evaluated individually in terms of morphometry, zona pellucida birefringence (ZPB) and relative abundance of selected candidate genes. Oocytes with an expanded cumulus (Ex), representing those with presumably high developmental competence, had a significantly thicker zona (18.2 vs 17.3µm) and a significantly higher ZPB (64.6 vs 62.1) than oocytes with a compacted cumulus (Cp). Concurrently, oocytes classified as highly developmentally competent (BCB+) had a significantly thicker zona (18.8 vs 16.1µm) and significantly higher ZPB (63.1 vs 61.3) compared with oocytes classified as having low developmental competence. Expression of TFAM, STAT3 and CKS2 was significantly higher in Ex compared with Cp oocytes, whereas expression of COX1, ATPV6E and DNMT1 was lower. Together, the data reveal that developmentally competent equine oocytes are larger in size, have higher ZPB values and exhibit a typical genetic signature of maternally derived transcripts compared with oocytes with lower in vitro developmental competence. PMID:23622680

Mohammadi-Sangcheshmeh, Abdollah; Held, Eva; Rings, Franca; Ghanem, Nasser; Salilew-Wondim, Dessie; Tesfaye, Dawit; Sieme, Harald; Schellander, Karl; Hoelker, Michael

2014-03-01

51

Thermal effects in laser-assisted pre-embryo zona drilling  

NASA Astrophysics Data System (ADS)

Diode lasers ((lambda) equals 1480 nm) are used with in vitro fertilization to dissect the zone pellucida (shell) of pre- embryos. A focused laser beam is applied in vitro to form a channel or trench in the zona pellucida. The procedure is used to facilitate biopsy or as a promoter of embryo hatching. We present examples and measurements of zona pellucida ablation using animal models. In using the laser it is vital not to damage pre-embryo cells, e.g., by overheating. In order to define safe regimes we have derived some thermal side effects of zona pellucida removal. The temperature profile in the beam and vicinity is predicted as function of laser pulse duration and power. In a crossed- beam experiment a HeNe laser probe is used to detect the temperature-induced change in the refractive index of an aqueous solution, and estimate local thermal gradient. We find that the diode laser beam produces superheated water approaching 200 degree(s)C on the beam axis. Thermal histories during and following the laser pulse are given for regions in the neighborhood of the beam. We conclude that an optimum regime exists with pulse duration

Douglas-Hamilton, Diarmaid H.; Conia, Jerome D.

2001-04-01

52

Laser-assisted zona pellucida thinning does not facilitate hatching and may disrupt the in vitro hatching process: a morphokinetic study in the mouse  

PubMed Central

STUDY QUESTION Does laser-assisted zona thinning of cleavage stage mouse embryos facilitate hatching in vitro? SUMMARY ANSWER No, unlike laser zona opening, zona thinning does not facilitate embryo hatching. WHAT IS KNOWN ALREADY Artificial opening of the zona pellucida facilitates hatching of mouse and human embryos. Laser-assisted zona thinning has also been used for the purpose of assisted hatching of human embryos but it has not been properly investigated in an animal model; thinning methods have produced inconsistent clinical results. STUDY DESIGN, SIZE, DURATION Time-lapse microscopy was used to study the hatching process in the mouse after zona opening and zona thinning; a control group of embryos was not zona-manipulated but exposed to the same laser energy. PARTICIPANTS/MATERIALS, SETTING, METHODS Eight-cell CB6F1/J mouse embryos were pooled and allocated to three groups (n = 56 per group): A control group of embryos that were exposed to a dose of laser energy focused outside the zona pellucida (zona intact); one experimental group of embryos in which the zona pellucida was opened by complete ablation using the same total number of pulses as the control group; a second experimental group of embryos in which the zona pellucida was thinned to establish a smooth lased area using the same number of pulses as used in the other two groups. The width of the zona opening was 25 ?m and width of the thinned area was 35 ?m. Development was monitored by time-lapse microscopy. Overall treatment differences for continuous variables were analyzed by analysis of variance and pairwise comparisons using the Student t-test allowing for unequal variances, while for categorical data, a standard chi-squared test was utilized for all pairwise comparisons. MAIN RESULTS AND THE ROLE OF CHANCE The frequency of complete hatching was 33.9% in the control group, 94.4% after zona opening, and 39.3% after zona thinning (overall group comparison, P < 0.0001). Overall, 60.7% of the zona-thinned embryos did not complete the hatching process and remained trapped within the zona; when they did hatch, they did not necessarily hatch from the zona-thinned area. Hatching in about one-third of the zona-intact embryos began with breaches at multiple sites by small groups of cells. Likewise, 53.6% of zona-thinned embryos had multiple breaches, always involving an area outside the thinned zone. Zona opening decreased multiple breaching and led to blastocyst escape an average of 14 h earlier than zona-thinned embryos and 5.5 h before control embryos (P = 0.0003). LIMITATIONS, REASONS FOR CAUTION The experiments presented here were limited to in vitro experiments performed in the mouse. Whether human embryos would behave the same way under similar circumstances is unknown. We postulate that zona thinning is not beneficial in human embryos. WIDER IMPLICATIONS OF THE FINDINGS The experiments demonstrate that zona thinning is not equivalent to zona opening for assisted hatching. The study provides reason for systematic reviews of assisted hatching trials to take the method of assisted hatching into consideration and not combine the results of zona thinning and zona opening procedures. STUDY FUNDING/COMPETING INTEREST(S) Institutional funds were used for the study. No competing interests are declared. PMID:25267786

Schimmel, Tim; Cohen, Jacques; Saunders, Helen; Alikani, Mina

2014-01-01

53

Clinical, Biochemical, and Molecular Characterization of Macronodular Adrenocortical Hyperplasia of the Zona Reticularis: A New Syndrome  

PubMed Central

Context: Macronodular adrenocortical hyperplasia classically presents with progressive hypercortisolemia and Cushing syndrome. We describe a 29-yr-old man with massive macronodular adrenocortical hyperplasia without hypercortisolemia but rather markedly elevated and nonsuppressible production of dehydroepiandrosterone (DHEA) and its sulfate (DHEAS). Objective: To characterize the clinical and molecular features of this case and to determine whether the tissue biochemically resembles the zona reticularis or fetal adrenal. Setting: University clinic, hospital, and laboratories. Design: Static and dynamic blood and urine testing were performed preoperatively. Tissue was studied by light microscopy, immunoblot, RNA microarray, and enzyme assay. Participant: A 29-yr-old man with incidentally discovered bilateral adrenal enlargement. Intervention: Bilateral adrenalectomy. Main Outcome Measures: Molecular studies compared with control samples. Results: Hypercortisolism and 21-hydroxylase deficiency were excluded. DHEA, DHEAS, and 17-hydroxypregnenolone were markedly elevated and did not suppress with dexamethasone 2 mg/d for 4 d. Homogenates of the adrenals demonstrated high 17-hydroxylase, good 17,20-lyase, and low or absent 21-hydroxylase and 3?-hydroxysteroid dehydrogenase activities. Immunoblots confirmed robust expression of cytochrome P450c17 and AKR1C3 but not P450c21. Microarray analysis demonstrated high CYP11A1 and CYP17A1 expression but low or absent HSD3B1, HSD3B2, and CYP21A2 expression. Expression of mRNA for cytochrome b5 (CYB5A) and AKR1C3, markers of the zona reticularis, were markedly elevated. Conclusion: This is the first case of macronodular hyperplasia of the adrenal zona reticularis confirmed with studies of enzyme activity, mRNA expression, and protein identification. We speculate that this condition can be clinically silent in men but might cause severe hyperandrogenemia in women. PMID:21084398

Ghayee, Hans K.; Rege, Juilee; Watumull, Lori M.; Nwariaku, Fiemu E.; Carrick, Kelley S.; Rainey, William E.; Miller, Walter L.

2011-01-01

54

A single domain of the ZP2 zona pellucida protein mediates gamete recognition in mice and humans  

PubMed Central

The extracellular zona pellucida surrounds ovulated eggs and mediates gamete recognition that is essential for mammalian fertilization. Zonae matrices contain three (mouse) or four (human) glycoproteins (ZP1–4), but which protein binds sperm remains controversial. A defining characteristic of an essential zona ligand is sterility after genetic ablation. We have established transgenic mice expressing human ZP4 that form zonae pellucidae in the absence of mouse or human ZP2. Neither mouse nor human sperm bound to these ovulated eggs, and these female mice were sterile after in vivo insemination or natural mating. The same phenotype was observed with truncated ZP2 that lacks a restricted domain within ZP251–149. Chimeric human/mouse ZP2 isoforms expressed in transgenic mice and recombinant peptide bead assays confirmed that this region accounts for the taxon specificity observed in human–mouse gamete recognition. These observations in transgenic mice document that the ZP251–149 sperm-binding domain is necessary for human and mouse gamete recognition and penetration through the zona pellucida. PMID:24934154

Avella, Matteo A.; Baibakov, Boris

2014-01-01

55

A single domain of the ZP2 zona pellucida protein mediates gamete recognition in mice and humans.  

PubMed

The extracellular zona pellucida surrounds ovulated eggs and mediates gamete recognition that is essential for mammalian fertilization. Zonae matrices contain three (mouse) or four (human) glycoproteins (ZP1-4), but which protein binds sperm remains controversial. A defining characteristic of an essential zona ligand is sterility after genetic ablation. We have established transgenic mice expressing human ZP4 that form zonae pellucidae in the absence of mouse or human ZP2. Neither mouse nor human sperm bound to these ovulated eggs, and these female mice were sterile after in vivo insemination or natural mating. The same phenotype was observed with truncated ZP2 that lacks a restricted domain within ZP2(51-149). Chimeric human/mouse ZP2 isoforms expressed in transgenic mice and recombinant peptide bead assays confirmed that this region accounts for the taxon specificity observed in human-mouse gamete recognition. These observations in transgenic mice document that the ZP2(51-149) sperm-binding domain is necessary for human and mouse gamete recognition and penetration through the zona pellucida. PMID:24934154

Avella, Matteo A; Baibakov, Boris; Dean, Jurrien

2014-06-23

56

Adrenocortical zonation results from lineage conversion of differentiated zona glomerulosa cells  

PubMed Central

Summary Lineage conversion of differentiated cells in response to hormonal feedback has yet to be described. To investigate this we studied the adrenal cortex, which is composed of functionally distinct concentric layers that develop postnatally, the outer zona Glomerulosa (zG) and the inner zona Fasiculata (zF). These layers have separate functions, are continuously renewed in response to physiological demands and are regulated by discrete hormonal feedback loops. Their cellular origin, lineage relationship and renewal mechanism, however, remain poorly understood. Cell fate mapping and gene deletion studies using zG-specific Cre expression demonstrate that differentiated zG cells undergo lineage conversion into zF cells. In addition, zG maintenance is dependent on the master transcriptional regulator Steroidogenic Factor 1 (SF-1) and zG-specific Sf-1 deletion prevents lineage conversion. These findings demonstrate that adrenocortical zonation and regeneration result from lineage conversion and may provide a paradigm for homeostatic cellular renewal in other tissues. PMID:24035414

Carlone, Diana L.; Shah, Manasvi; Guagliardo, Nick A.; Barrett, Paula Q.; Gomez-Sanchez, Celso E.; Majzoub, Joseph A.; Breault, David T.

2013-01-01

57

Ovastacin, a cortical granule protease, cleaves ZP2 in the zona pellucida to prevent polyspermy  

PubMed Central

The mouse zona pellucida is composed of three glycoproteins (ZP1, ZP2, and ZP3), of which ZP2 is proteolytically cleaved after gamete fusion to prevent polyspermy. This cleavage is associated with exocytosis of cortical granules that are peripherally located subcellular organelles unique to ovulated eggs. Based on the cleavage site of ZP2, ovastacin was selected as a candidate protease. Encoded by the single-copy Astl gene, ovastacin is an oocyte-specific member of the astacin family of metalloendoproteases. Using specific antiserum, ovastacin was detected in cortical granules before, but not after, fertilization. Recombinant ovastacin cleaved ZP2 in native zonae pellucidae, documenting that ZP2 was a direct substrate of this metalloendoprotease. Female mice lacking ovastacin did not cleave ZP2 after fertilization, and mouse sperm bound as well to Astl-null two-cell embryos as they did to normal eggs. Ovastacin is a pioneer component of mouse cortical granules and plays a definitive role in the postfertilization block to sperm binding that ensures monospermic fertilization and successful development. PMID:22472438

Burkart, Anna D.; Xiong, Bo; Baibakov, Boris; Jiménez-Movilla, Maria

2012-01-01

58

The human zona pellucida and scanning electron microscopy. Reality or artifacts?  

PubMed

The surface micro-morphology of the zona pellucida (ZP) was investigated in 158 inseminated but unfertilized mature human oocytes derived from assisted reproduction trials (ART) by means of traditional scanning electron microscopy (SEM) techniques (gold coating and conductive staining methods) and saponin-ruthenium red-osmium tetroxide-thiocarbohydrazide method (Sap-RR-Os-TC). The main aspect of the ZP by traditional SEM (122 oocytes) consisted in a porous, net-like structure (97 oocytes), whereas a nearly smooth or compact structure of ZP was detected in 25 oocytes (79.5% vs 20.5%). Using Sap RR-Os-TC method on 36 oocytes, 31 oocytes showed ZP with alternating tight and large meshed networks, whereas 5 oocytes displayed only tight meshed network (86.1% vs 13.9%). Due to our well standardized procedures, to the stabilizing action of the conductive staining on the zona material and similar results obtained with the use of Sap RR-Os-TC method, we confidentially regard the ZP changes, occurring in oocytes of various groups, as genuine features, likely related to their actual maturation status, rather than as artifacts. In addition, we emphasize the concept that a modern view of the ZP surface implies the best evidence of crossing filaments' network. We think that the ZP "spongy" or "compact" appearance is only the result of microfilaments network collapse, not the true three-dimensional (3-D) representation of ZP structure. PMID:11732593

Familiari, G; Relucenti, M; Ermini, M; Verlengia, C; Nottola, S A; Motta, P M

2001-01-01

59

Structural changes of the zona pellucida during fertilization and embryo development.  

PubMed

The zona pellucida (ZP) is a unique extracellular coat surrounding the maturing oocyte, during ovulation, fertilization, and early embryo development. It is formed by three/four glycoproteins. Ultrastructural data obtained with transmission (TEM) and scanning electron microscopy (SEM) were compared with molecular data on the glycoproteins network from ovulation to blastocyst formation. Molecular models are quite different to the morphology obtained with TEM, which shows a microfibrillar architecture, or with SEM, which shows a spongy or smooth surface. The saponin-ruthenium red-osmium tetroxide-thiocarbohydrazide technique allows to show the ZP real microfilamentous structure and the related functional changes. These results support an ultrastructural supramolecular model, more similar and comparable to molecular models related with the glycoprotein network. A detailed mapping of single mammalian ZP proteins and their relationship within the supramolecular architecture of the zona matrix would clearly supply insights into the molecular basis of sperm-egg recognition. Differences in ZP glycoproteins among mammals do not affect structural morphology; further studies are needed to clarify the relationships between ultrastructural and molecular organizations. PMID:18508691

Familiari, Giuseppe; Heyn, Rosemarie; Relucenti, Michela; Sathananthan, Henry

2008-01-01

60

Structural Analysis of Peptide-Analogues of Human Zona Pellucida ZP1 Protein with Amyloidogenic Properties: Insights into Mammalian Zona Pellucida Formation  

PubMed Central

Zona pellucida (ZP) is an extracellular matrix surrounding and protecting mammalian and fish oocytes, which is responsible for sperm binding. Mammalian ZP consists of three to four glycoproteins, called ZP1, ZP2, ZP3, ZP4. These proteins polymerize into long interconnected filaments, through a common structural unit, known as the ZP domain, which consists of two domains, ZP-N and ZP-C. ZP is related in function to silkmoth chorion and in an evolutionary fashion to the teleostean fish chorion, also fibrous structures protecting the oocyte and embryo, that both have been proven to be functional amyloids. Two peptides were predicted as ‘aggregation-prone’ by our prediction tool, AMYLPRED, from the sequence of the human ZP1-N domain. Here, we present results from transmission electron microscopy, X-ray diffraction, Congo red staining and attenuated total reflectance Fourier-transform infrared spectroscopy (ATR FT-IR), of two synthetic peptide-analogues of these predicted ‘aggregation-prone’ parts of the human ZP1-N domain, that we consider crucial for ZP protein polymerization, showing that they both self-assemble into amyloid-like fibrils. Based on our experimental data, we propose that human ZP (hZP) might be considered as a novel, putative, natural protective amyloid, in close analogy to silkmoth and teleostean fish chorions. Experiments are in progress to verify this proposal. We also attempt to provide insights into ZP formation, proposing a possible model for hZP1-N domain polymerization. PMID:24069181

Louros, Nikolaos N.; Iconomidou, Vassiliki A.; Giannelou, Polina; Hamodrakas, Stavros J.

2013-01-01

61

GABA, progesterone and zona pellucida activation of PLA2 and regulation by MEK-ERK1/2 during acrosomal exocytosis  

E-print Network

GABA, progesterone and zona pellucida activation of PLA2 and regulation by MEK-ERK1/2 during exocytosis, and if the MEK- ERK1/2 pathway modulates PLA2 activation initiated by GABA, progesterone or zona and that MEK-ERK1/2 are involved in PLA2 regulation during this process. Ã? 2005 Federation of European

Museo Nacional de Ciencias Naturales

62

The Use of Zona-Free Animal Ova as a Test-System for the Assessment of the Fertilizing Capacity of Human Spermatozoa  

Microsoft Academic Search

Human spermatozoa are initially incapable of penetrating zona pellucida-free animal (hamster) ova but gain the ability to do so when incubated several hours in vitro. Experimental evidence sug- gests that this ability is associated with the completion of sperm capacitation and the acrosome reaction. Thus it appears that zona-free animal ova can be substituted for human ova in the prelim-

R. YANAGIMACHI; H. YANAGIMACHI; B. J. ROGERS

1976-01-01

63

Specific antibodies to porcine zona pellucida detected by quantitative radioimmunoassay in both fertile and infertile women  

SciTech Connect

The specific radioimmunoassay system was developed for the titration of the antibodies to porcine zona pellucida (ZP) in human sera by using /sup 125/I-labeled purified porcine ZP as antigen, which is known to have cross-reactivity with human ZP. The antibodies in human sera were detected in 3 of 11 (27%) women with unexplained infertility, in 16 of 48 (33%) amenorrheic patients, in 4 of 12 (33%) fertile women, and in 3 of 10 (30%) men. Moreover, antibody titers in infertile women were no higher than those in fertile women and in men. These results seem to suggest that the antibodies in human sera that cross-react with porcine ZP may not be an important factor in causing infertility in women.

Kurachi, H.; Wakimoto, H.; Sakumoto, T.; Aono, T.; Kurachi, K.

1984-02-01

64

Boletín del Instituto Nacional del Cáncer  

Cancer.gov

La edición electrónica del Boletín del Instituto Nacional del Cáncer se publicó mensualmente desde septiembre de 2009 hasta enero de 2013, con el objetivo de difundir información sobre la investigación del cáncer, tanto de estudios financiados por el NCI y otras dependencias federales, así como de investigaciones realizadas por instituciones en Estados Unidos y alrededor del mundo.

65

Embryological, clinical and ultrastructural study of human oocytes presenting indented zona pellucida.  

PubMed

Summary Human oocyte dysmorphisms attain a large proportion of retrieved oocytes from assisted reproductive technology (ART) treatment cycles. Extracytoplasmic defects involve abnormal morphology of the zona pellucida (ZP), perivitelline space and first polar body. The aim of the present study was to describe a novel dysmorphism affecting the ZP, indented ZP. We also evaluated the clinical, embryological and ultrastructural features of these cases. We evaluated all ART treatment cycles during 7 consecutive years and found 13 treatment cycles (six patients) with all oocytes presenting an indented ZP. In addition, these oocytes presented total or partial absence of the perivitelline space, absence of resistance to ZP and oolemma penetration during microinjection, and low ooplasm viscosity during aspiration. This novel described dysmorphism was recurrent and attained all oocytes in three cases that had more than one treatment cycle. When compared with controls, data showed significant low oocyte maturity (42% versus 81.6%) and high cycle cancellation (30.8% versus 8.5%) rates, normal degeneration (3.4% versus 6.3%) and fertilization rates (69% versus 69.5%), and low pregnancy (15.4% versus 33.3%) and live-birth delivery (7.7% versus 27.7%) rates per cycle. Ultrastructure analysis revealed a zona pellucida structure with large empty electrolucent regions, an outer ZP layer with an indented surface with protuberances and a thick inner ZP that obliterated the perivitelline space. There was evidence of exocytosis of ZP material by the oocyte. In conclusion, oocytes with this novel described dysmorphism (indented ZP) are associated with low maturity, pregnancy and live-birth delivery rates. PMID:23992046

Sousa, M; da Silva, J Teixeira; Silva, J; Cunha, M; Viana, P; Oliveira, E; Sá, R; Soares, C; Oliveira, C; Barros, A

2015-02-01

66

Ram seminal plasma proteins contribute to sperm capacitation and modulate sperm-zona pellucida interaction.  

PubMed

Incubation of ram spermatozoa in capacitating conditions with cAMP-elevating agents promotes a progressive time-dependent increase in the capacitated sperm subpopulation. In this study, the fertilizing capacity of ram spermatozoa (ability to bind to the zona pellucida, ZBA rate) capacitated in these conditions was determined. The results showed an increase (P < 0.001) in ZBA rate related to control samples in basal medium that contained BSA, calcium, and bicarbonate (1.97 ± 0.19 vs. 1.31 ± 0.09 sperm bound/oocyte, respectively). A significant correlation between protein tyrosine phosphorylation and ZBA rate (P < 0.05, r = 0.501) corroborated that incubation in a "high-cAMP" environment improves the fertilizing ability of ram spermatozoa. Likewise, the presence of two seminal plasma (SP) proteins able to protect sperm against cold shock (RSVP14 and RSVP20) was evidenced in both SP and the ram sperm surface, and their influence in the fertilizing ability of spermatozoa capacitated in basal medium or with cAMP-elevating agents was determined. The results verified that RSVP14 and RSVP20 act as decapacitating factors given that their addition to SP-free sperm samples previously to capacitation maintained high proportions of the noncapacitated sperm pattern with no increase in protein tyrosine phosphorylation. However, the obtained ZBA rate in the high-cAMP-containing samples was increased in the presence of RSVP20 (P < 0.05). These findings would indicate that the stimulating effect exerted by this protein on the sperm-oocyte binding occurs downstream from the cAMP generation and that the mechanisms by which RSVP20 promotes the zona pellucida binding might be independent of protein tyrosine phosphorylation. PMID:25515364

Luna, C; Colás, C; Casao, A; Serrano, E; Domingo, J; Pérez-Pé, R; Cebrián-Pérez, J A; Muiño-Blanco, T

2015-03-01

67

A role for protein tyrosine kinase in the steroidogenic pathway of angiotensin II in bovine zona glomerulosa cells  

Microsoft Academic Search

Stimulation of aldosterone synthesis in bovine adrenal zona glomerulosa (ZGB) cells by angiotensin II (AngII) is believed to be mediated by the phospholipase C (PLC) pathway that results in the increase of cytosolic free calcium concentration and in the activation of protein kinase C (PKC). However, the cell proliferation and contraction associated with AngII action are known to be mediated

V. Bodart; H. Ong; A. De Léan

1995-01-01

68

The effects of oocyte storage and cumulus cell presence on canine zona penetration by domestic dog spermatozoa  

Microsoft Academic Search

Zona penetration assays (ZPAs) have been developed in numerous species to evaluate sperm fertilizing potential. Preservation methods to stockpile oocytes would be beneficial because of the difficulty in obtaining sufficient numbers of fresh oocytes. Using a canine ZPA, the objectives of this study were to evaluate: (1) two methods of storing canine oocytes (salt storage and intrafollicular cooling) and (2)

Gabriela F. Mastromonaco; Margery A. Hay; Karen L. Goodrowe

2002-01-01

69

Male Marmoset Monkeys Express an Adrenal Fetal Zone at Birth, But Not a Zona Reticularis in Adulthood  

E-print Network

Male Marmoset Monkeys Express an Adrenal Fetal Zone at Birth, But Not a Zona Reticularis monkeys produce DS at birth, but unlike humans and rhesus monkeys, do not produce comparable amounts to rhesus monkeys, but not cytb5. HPLC analysis revealed similar 17 -hydroxylase action on preg- nenolone

Saltzman, Wendy

70

Análisis descriptivo del tamaño relativo del gasto del gobierno chileno  

Microsoft Academic Search

En este trabajo se examina el tamaño relativo del Gobierno chileno a través de una comparación internacional con valores equivalentes de otros países. Adicionalmente hay un análisis similar para dos componentes importantes del gasto público: educación y salud. El gasto del Gobierno de Chile, valor en torno del 20% (PIB), está junto al tercio inferior de países que poseen un

Eduardo Engel; Patricio Meller; Claudio Bravo

1998-01-01

71

Prediccin de los impactos del cambio climtico en la distribucin sobre las especies de Lepidoptera. El caso  

E-print Network

Lepidoptera. El caso del género Boloria Moore, 1900 en la Península Ibérica (Lepidoptera: Nymphalidae) H. Romo distribución de los Lepidoptera, lo que podría afectar más a especies propias de montaña en zonas templadas tendencias se confirman. PALABRAS CLAVE: Lepidoptera, Nymphalidae, Boloria, cambio climático, AUC, Max

García-Barros, Enrique

72

Biochemical characterization of hamster oviductin as a sulphated zona pellucida-binding glycoprotein.  

PubMed Central

Oviductins are a family of glycoproteins, synthesized and released by oviductal secretory cells, which bind to the zona pellucida of the oocyte after ovulation. Hamster oviductin migrates as diffuse species of 160-350 kDa during SDS/PAGE under reducing as well as non-reducing conditions. In this report, we describe the one-step purification of hamster oviductin using either immuno- or lectin-affinity chromatography. Probing with specific lectins showed that the glycoprotein contains terminal alpha-D-GalNAc, and either terminal alpha-D-NeuAc or non-terminal beta-D-(GlcNAc)2 residues, but fails to react with concanavalin A and Ulex Europeus A-1 lectins which are specific for branched alpha-D-mannose and alpha-L-fucose moieties respectively. Intraovarian oocytes do not contain this glycoprotein and we demonstrate here that the immunoaffinity-purified oviductin readily binds to their zonae pellucidae in vitro, thus mimicking the in vivo phenomenon. Two major immunologically related forms of hamster oviductin (named alpha and beta) were characterized using one- and two-dimensional gel electrophoresis. The alpha-form (160-210 kDa) has an acidic pI of 3.5-4.5 and the beta-form (approx. 210-350 kDa) is localized at the cathodic site in the isoelectric focusing dimension; in between these two major forms lies a smear of minor-charge isomers. Peptide mapping of both major forms with papain and Staphylococcus aureus V8 protease yielded fragments of identical size. Moreover, the two forms share the same N-terminal sequence which display no significant homology with other reported proteins. Treatment with trifluoromethanesulphonic acid showed that a protein with the size and pI of the alpha-form can be generated from the beta-form. Both the alpha- and beta-forms are sulphated on O-linked oligosaccharide side chains but are not phosphorylated. Collectively, these results suggest that the hamster oviductin polymorphism observed in two-dimensional PAGE is a consequence of different glycosylation patterns and not the polypeptide chain itself. Hamster oviductin is mostly O-glycosylated and contains a few N-linked oligosaccharide side chains (approx. 10 kDa). We propose that hamster oviductin is a mucin-type glycoprotein which might act as a protective secretion influencing the first steps of the reproductive process necessary for the normal triggering of fertilization and early embryonic development. Images Figure 1 Figure 2 Figure 3 Figure 4 Figure 5 Figure 6 Figure 7 Figure 8 PMID:8240241

Malette, B; Bleau, G

1993-01-01

73

Histological and ultrastructural study of Zona Radiata in oocyte of common carp Cyprinus carpio (Linnaeus 1758).  

PubMed

Oocytes and fertilized eggs of teleosts are enclosed by a non-cellular envelope, the Zona Radiata (ZR). It has structural differences in various ecological and systematic groups of fish. Ultrastructural analysis has shown that ZR is formed during the previtellogenic stages. Morphological characteristics of ZR suggest various functional and ecological importance that are exhibited during oocyte development and adaptations to the released oocytes. In this research work, the structure of ZR in oocytes of Cyprinus carpio was investigated from its first appearance until final growth stage as matured ones. For this purpose, the left ovary was fixed in Bouin's solution. The histological slide preparations were studied by both light and scanning electron microscope. ZR was not observed in stage I and stage II of oocyte development. The onset of ZR appearance was in stage III which gradually increased in thickness until stage IV (vitellogenesis) and lowered in thickness during following stage V. Very fine outgrowths were observed growing from oolemma. ZR was shown porous on both inner and outer sides. Striations (pore-canals) were distinguished with crenated edges. PMID:20605473

Shabanipour, N; Hossayni, S N

2010-10-01

74

Identification of bovine embryos cultured in groups by attachment of barcodes to the zona pellucida.  

PubMed

The low number of oocytes collected from unstimulated donors by ovum pick-up means that embryos produced from each individual female have to be cultured individually or in very small groups. However, it has been demonstrated that single-embryo culture is less efficient than embryo culture in groups. To overcome this limitation, we developed a direct embryo-tagging system, which allows the collective culture of embryos from different origins whilst preserving their pedigree. Presumptive bovine zygotes were tagged with eight wheat-germ agglutinin biofunctionalised polysilicon barcodes attached to the outer surface of the zona pellucida (ZP). Four different barcodes were used to encode groups of 20-25 embryos, which were then cultured in the same drop. Cleavage, Day-7 and Day-8 blastocysts and barcode retention rates were assessed. In addition, Day-7 blastocysts were vitrified and warmed. Barcode attachment to the ZP of bovine embryos affected neither in vitro embryo development nor post-warming survival of the tagged embryos. All the embryos maintained barcodes attached until Day 8 of culture (3.63±0.37 barcodes per embryo) and could be identified. In conclusion, identification of embryos by barcodes attached to the ZP is feasible and will allow the culture of embryos from different donors in the same drop. PMID:24942183

Novo, Sergi; Morató, Roser; Penon, Oriol; Duran, Sara; Barrios, Leonardo; Nogués, Carme; Plaza, José Antonio; Pérez-García, Luisa; Mogas, Teresa; Ibáñez, Elena

2014-06-01

75

Arx is required for specification of the zona incerta and reticular nucleus of the thalamus.  

PubMed

Mutations in the aristaless-related homeobox (ARX) gene result in a spectrum of structural and functional nervous system disorders including lissencephaly, movement disorders, intellectual disabilities, and epilepsy. Some patients also have symptoms indicating hypothalamic dysfunction, but little is known about the role of ARX in diencephalic development. To begin evaluating diencephalic defects, we examined the expression of a panel of known genes and gene products that label specific diencephalic nuclei in 2 different Arx mutant mouse lines at E18.5. Male mice engineered to have a polyalanine expansion mutation (Arx) revealed no expression differences in any diencephalic nucleus when compared with wild-type littermates. In contrast, mice null for Arx (Arx) lost expression of specific markers of the thalamic reticular nucleus and zona incerta (ZI) while retaining expression in other thalamic nuclei and in the hypothalamus. Tyrosine hydroxylase, a marker of the dopaminergic A13 subnucleus of ZI, was among those lost, suggesting a requirement for Arx in normal thalamic reticular nucleus and ZI development and, specifically, for A13 dopaminergic fate. Because the ZI and A13 regions make connections to several hypothalamic nuclei, such misspecification may contribute to the "hypothalamic dysfunction" observed in some patients. PMID:24487799

Sunnen, C Nicole; Simonet, Jacqueline C; Marsh, Eric D; Golden, Jeffrey A

2014-03-01

76

Effects of nonylphenol on aldosterone release from rat zona glomerulosa cells.  

PubMed

Alkylphenol ethoxylate, which consists of approximately 80% nonylphenol ethoxylate (NPE), is a major nonionic surfactant. Nonylphenol (NP), the primary degradation product of NPE, has been reported to interfere with reproduction in fish, reptiles, and mammals by inducing cell death in the gonads and by affecting other reproductive parameters. However, the effects of NP on rat adrenal zona glomerulosa cells (ZG) and the underlying mechanisms remain unclear. In this study, we explored the effects of NP on aldosterone release. ZG cells were incubated with NP in the presence or absence of the secretagogues angiotensin II (ANG II), potassium, 8-Br-cAMP, 25-OH-cholesterol, corticosterone or cyclopiazonic acid (CPA). After performing radioimmunoassay (RIA) and Western blot analysis, we found that (1) NP stimulated aldosterone release in cells induced by ANG II, KCl, 8-Br-cAMP, 25-OH-cholesterol, corticosterone, and CPA; (2) NP triggered the release of higher amounts of pregnenolone in cells treated with vehicle and 25-OH-cholesterol+trilostane than in cells treated with other compounds; and (3) the stimulatory effect of NP seemed to be mediated through steroidogenic acute regulatory protein (StAR) and aldosterone synthase activity. These observations suggest that the effects of NP are mediated via increased free Ca(2+) in the cytoplasm. PMID:22001352

Chang, Ling-Ling; Wun, Wan-Song Alfred; Wang, Paulus S

2012-01-01

77

Zonadhesin Is Essential for Species Specificity of Sperm Adhesion to the Egg Zona Pellucida*  

PubMed Central

Interaction of rapidly evolving molecules imparts species specificity to sperm-egg recognition in marine invertebrates, but it is unclear whether comparable interactions occur during fertilization in any vertebrate species. In mammals, the sperm acrosomal protein zonadhesin is a rapidly evolving molecule with species-specific binding activity for the egg zona pellucida (ZP). Here we show using null mice produced by targeted disruption of Zan that zonadhesin confers species specificity to sperm-ZP adhesion. Sperm capacitation selectively exposed a partial von Willebrand D domain of mouse zonadhesin on the surface of living, motile cells. Antibodies to the exposed domain inhibited adhesion of wild-type spermatozoa to the mouse ZP but did not inhibit adhesion of spermatozoa lacking zonadhesin. Zan?/? males were fertile, and their spermatozoa readily fertilized mouse eggs in vitro. Remarkably, however, loss of zonadhesin increased adhesion of mouse spermatozoa to pig, cow, and rabbit ZP but not mouse ZP. We conclude that zonadhesin mediates species-specific ZP adhesion, and Zan?/? males are fertile because their spermatozoa retain adhesion capability that is not species-specific. Mammalian sperm-ZP adhesion is therefore molecularly robust, and species-specific egg recognition by a protein in the sperm acrosome is conserved between invertebrates and vertebrates, even though the adhesion molecules themselves are unrelated. PMID:20529856

Tardif, Steve; Wilson, Michael D.; Wagner, Rebecca; Hunt, Peter; Gertsenstein, Marina; Nagy, Andras; Lobe, Corrinne; Koop, Ben F.; Hardy, Daniel M.

2010-01-01

78

The zona incerta modulates spontaneous spike-wave discharges in the rat.  

PubMed

The contribution of the zona incerta (ZI) of the thalamus on spike-wave discharges (SWDs) was investigated. Chronic recordings of bilateral cortices, bilateral vibrissa muscle, and unilateral ZI were performed in Long-Evans rats to examine the functional role of SWDs. Rhythmic ZI activity appeared at the beginning of SWD and was accompanied by higher-oscillation frequencies and larger spike magnitudes. Bilateral lidocaine injections into the mystacial pads led to a decreased oscillation frequency of SWDs, but the phenomenon of ZI-related spike magnitude enhancement was preserved. Moreover, 800-Hz ZI microstimulation terminates most of the SWDs and whisker twitching (WT; >80%). In contrast, 200-Hz ZI microstimulation selectively stops WTs but not SWDs. Stimulation of the thalamic ventroposteriomedial nucleus showed no obvious effect on terminating SWDs. A unilateral ZI lesion resulted in a significant reduction of 7- to 12-Hz power of both the ipsilateral cortical and contralateral vibrissae muscle activities during SWDs. Intraincertal microinfusion of muscimol showed a significant inhibition on SWDs. Our present data suggest that the ZI actively modulates the SWD magnitude and WT behavior. PMID:23446687

Shaw, Fu-Zen; Liao, Yi-Fang; Chen, Ruei-Feng; Huang, Yu-Hsing; Lin, Rick C S

2013-05-01

79

Glycoprotein from the liver constitutes the inner layer of the egg envelope (zona pellucida interna) of the fish, Oryzias latipes  

SciTech Connect

A glycoprotein from the liver, which shares epitopes with chorion (egg envelope or zona pellucida) glycoproteins, is present only in the spawning female fish, Oryzias latipes, under natural conditions. This spawning female-specific (SF) substance is distinct from vitellogenin but closely resembles a major glycoprotein component, ZI-3, of the inner layer (zona radiata interna) of the ovarian egg envelope with respect to some biochemical and immunochemical characteristics. Here we report that the (/sup 125/I)SF substance, injected into the abdominal cavity of the spawning female fish, was rapidly transported by the blood circulation into the ovary and incorporated into the inner layer of egg envelope of the growing oocytes. The result strongly suggests that the SF substance from the liver is a precursor substance of the major component, ZI-3, of the inner layer of egg envelope in the fish.

Hamazaki, T.S.; Nagahama, Y.; Iuchi, I.; Yamagami, K.

1989-05-01

80

Conserved developmental expression of Fezf in chordates and Drosophila and the origin of the Zona Limitans Intrathalamica (ZLI) brain organizer  

Microsoft Academic Search

BACKGROUND: The zona limitans intrathalamica (ZLI) and the isthmus organizer (IsO) are two major secondary organizers of vertebrate brain development. These organizers are located at the interface of the expression domains of key patterning genes (Fezf-Irx and Otx-Gbx, respectively). To gain insights into the evolutionary origin of the ZLI, we studied Fezf in bilaterians. RESULTS: In this paper, we identified

Manuel Irimia; Cristina Piñeiro; Ignacio Maeso; José Luis Gómez-Skarmeta; Fernando Casares; Jordi Garcia-Fernàndez

2010-01-01

81

A simplified technique for embryo biopsy: Use of the same micropipette for zona drilling and blastomere aspiration  

Microsoft Academic Search

Purpose: Using different micropipettes for zona drilling and blastomere aspiration for embryo biopsy is prevalent at centers of preimplantation\\u000a genetic diagnosis. The purpose of our study was to simplify the technique by using only one micropipette.\\u000a \\u000a \\u000a Methods: In this animal model, ICR mouse embryos at the four-cell stage (n=446) were randomly allocated into two groups: a biopsied\\u000a group (n=224) for

Shee-Uan Chen; Hong-Nerng Ho; Hsin-Fu Chen; Kuang-Han Chao; Su-Cheng Huang; Tzu-Yao Lee; Yu-Shih Yang

1997-01-01

82

Infertile couples with normal counts who require subzonal sperm insertion possess a fertility defect that affects zona pellucida penetration.  

PubMed

The results of subzonal sperm insertion (SUZI) have been retrospectively analysed in a subset of patients with normal sperm counts who were found to require SUZI because of poor or absent fertilization of zona-intact oocytes. This patient group is of particular interest because male factor-related infertility cannot be due to insufficient numbers of spermatozoa reaching the oocytes. Thus, failed fertilization can be attributed to deficiencies in one or more steps in the fertilization process, and SUZI provides a method of distinguishing defects of zona pellucida penetration from gamete fusion. A total of 26 such patients were treated identically to and concurrently with a much larger group of SUZI candidates who typically suffered from oligozoospermia, and fertilization results were compared. Fertilization rates after SUZI were higher in patients with normal counts than in oligozoospermic patients (51 and 26% respectively), indicating that the proportion of spermatozoa capable of fusing with the oocyte is the same or higher in the group with normal counts. In addition, nearly all SUZI procedures led to fertilization (23/26), with two out of three failed fertilizations occurring in cases where two or less oocytes were manipulated, results which further indicate that failed fertilization in these patients is not due to a defect at the level of gamete fusion. These findings suggest that infertility in these patients is based upon the inability of the spermatozoa to reach the oolemma and thus, that their fertility defect resides at the step of zona penetration. PMID:7714153

Lih, C H; Grunfeld, L; Sandler, B; Drews, M R; Navot, D; Gordon, J W

1994-12-01

83

Characterization of cell surface polypeptides of unfertilized, fertilized, and protease-treated zona-free mouse eggs  

SciTech Connect

The polypeptide composition of unfertilized, fertilized, and protease-treated zona-free mouse eggs was evaluated in this study. Zona-free eggs were radioiodinated by an Iodogen-catalyzed reaction. Light microscopic autoradiography of egg sections revealed that labeling was restricted to the cell surface. Labeled eggs were solubilized, and cell surface polypeptides were identified by one-dimensional SDS polyacrylamide gel electrophoresis and autoradiography. The unfertilized egg demonstrated 8-10 peptides that incorporated {sup 125}I, with major bands observed at approximately 145-150, 94, and 23 kilodaltons (kD). Zona-free eggs fertilized in vitro and then radiolabeled demonstrated several new bands in comparison to unfertilized eggs, with a major band appearing at approximately 36 kD. Treatment of radiolabeled unfertilized eggs with either trypsin or chymotrypsin (1 mg/ml for 5-20 min) caused enzyme-specific modifications in labeled polypeptides. Trypsin (T) treatment resulted in time-dependant modification of the three major peptides at 145-150, 94, and 23 kD. Chymotrypsin (CT) treatment, in contrast, was associated with loss or modification of the 94 kD band, with no apparent effect on either the 145-150 or 23 kD band. Taken together with previous data indicating that T or CT egg treatment interferes with sperm-egg attachment and fusion, these results suggest a possible role for the 94 kD protein in sperm-egg interaction.

Boldt, J.; Gunter, L.E.; Howe, A.M. (Medical College of Georgia, Augusta (USA))

1989-05-01

84

Sequence and analysis of zona pellucida 2 cDNA (ZP2) from a marsupial, the brushtail possum, Trichosurus vulpecula.  

PubMed

All mammalian eggs are surrounded by the zona pellucida, an extracellular coat involved in vital functions during fertilization and early development. The zona pellucida glycoproteins are promising antigenic targets for development of contraceptive vaccines to control pest populations of marsupials in Australia and New Zealand. Our current understanding of the function of the zona pellucida glycoproteins is based almost entirely on the mouse and may not be representative of gamete interactions in all eutherian or marsupial mammals. This study reports the isolation and characterization of the ZP2 gene from the brushtail possum (Trichosurus vulpecula). The brushtail possum ZP2 mRNA is 2,182 nucleotides long with an open reading frame coding for a polypeptide chain of 712 amino acids with a molecular mass of 79,542 d. The deduced amino acid sequence of possum ZP2 is 48 to 55% identical to that of eutherian mammals. It shares several structural characteristics including N-linked glycosylation sites, location and number of cysteine residues, and hydropathy profile. The brushtail possum ZP2 gene is expressed exclusively in the ovary. Further studies are planned to elucidate the specific site of ZP2 expression within the ovary and its function during fertilization in marsupials. PMID:9771653

Mate, K E; McCartney, C A

1998-11-01

85

Uncontacted Waorani in the Yasuní Biosphere Reserve: Geographical Validation of the Zona Intangible Tagaeri Taromenane (ZITT)  

PubMed Central

The Tagaeri Taromenane People are two indigenous groups belonging to the Waorani first nation living in voluntary isolation within the Napo region of the western Amazon rainforest. To protect their territory the Ecuadorean State has declared and geographically defined, by Decrees, the Zona Intangible Tagaeri Taromenane (ZITT). This zone is located within the UNESCO Yasuní Biosphere Reserve (1989), one of the most biodiverse areas in the world. Due to several hydrocarbon reserve exploitation projects running in the area and the advancing of a large-scale deforestation front, the survival of these groups is presently at risk. The general aim was to validate the ZITT boundary using the geographical references included in the Decree 2187 (2007) by analyzing the geomorphological characteristics of the area. Remote sensing data such as Digital Elevation Models (DEM), Landsat imagery, topographic cartography of IGM-Ecuador, and fieldwork geographical data have been integrated and processed by Geographical Information System (GIS). The ZITT presents two levels of geographic inconsistencies. The first dimension is about the serious cartographical weaknesses in the perimeter delimitation related to the impossibility of linking two rivers belonging to different basins while the second deals with the perimeter line not respecting the hydrographic network. The GIS analysis results clearly show that ZITT boundary is cartographically nonsense due to the impossibility of mapping out the perimeter. Furthermore, GIS analysis of anthropological data shows presence of Tagaeri Taromenane clans outside the ZITT perimeter, within oil production areas and in nearby farmer settlements, reflecting the limits of protection policies for non-contacted indigenous territory. The delimitation of the ZITT followed a traditional pattern of geometric boundary not taking into account the nomadic characteristic of Tagaeri Taromenane: it is necessary to adopt geographical approaches to recognize the indigenous right to their liveable territories in the complex territorialities enacted by different stakeholders. PMID:23840436

Pappalardo, Salvatore Eugenio; De Marchi, Massimo; Ferrarese, Francesco

2013-01-01

86

Rat subthalamic nucleus and zona incerta share extensively overlapped representations of cortical functional territories.  

PubMed

The subthalamic nucleus (STN) and the zona incerta (ZI) are two major structures of the subthalamus. The STN has strong connections between the basal ganglia and related nuclei. The ZI has strong connections between brainstem reticular nuclei, sensory nuclei, and nonspecific thalamic nuclei. Both the STN and ZI receive heavy projections from a subgroup of layer V neurons in the cerebral cortex. The major goal of this study was to investigate the following two questions about the cortico-subthalamic projections using the lentivirus anterograde tracing method in the rat: 1) whether cortical projections to the STN and ZI have independent functional organizations or a global organization encompassing the entire subthalamus as a whole; and 2) how the cortical functional zones are represented in the subthalamus. This study revealed that the subthalamus receives heavy projections from the motor and sensory cortices, that the cortico-subthalamic projections have a large-scale functional organization that encompasses both the STN and two subdivisions of the ZI, and that the group of cortical axons that originate from a particular area of the cortex sequentially innervate and form separate terminal fields in the STN and ZI. The terminal zones formed by different cortical functional areas have highly overlapped and fuzzy borders, as do the somatotopic representations of the sensorimotor cortex in the subthalamus. The present study suggests that the layer V neurons in the wide areas of the sensorimotor cortex simultaneously control STN and ZI neurons. Together with other known afferent and efferent connections, possible new functionality of the STN and ZI is discussed. PMID:25048050

Kita, Takako; Osten, Pavel; Kita, Hitoshi

2014-12-15

87

Uncontacted Waorani in the Yasuní Biosphere Reserve: Geographical Validation of the Zona Intangible Tagaeri Taromenane (ZITT).  

PubMed

The Tagaeri Taromenane People are two indigenous groups belonging to the Waorani first nation living in voluntary isolation within the Napo region of the western Amazon rainforest. To protect their territory the Ecuadorean State has declared and geographically defined, by Decrees, the Zona Intangible Tagaeri Taromenane (ZITT). This zone is located within the UNESCO Yasuní Biosphere Reserve (1989), one of the most biodiverse areas in the world. Due to several hydrocarbon reserve exploitation projects running in the area and the advancing of a large-scale deforestation front, the survival of these groups is presently at risk. The general aim was to validate the ZITT boundary using the geographical references included in the Decree 2187 (2007) by analyzing the geomorphological characteristics of the area. Remote sensing data such as Digital Elevation Models (DEM), Landsat imagery, topographic cartography of IGM-Ecuador, and fieldwork geographical data have been integrated and processed by Geographical Information System (GIS). The ZITT presents two levels of geographic inconsistencies. The first dimension is about the serious cartographical weaknesses in the perimeter delimitation related to the impossibility of linking two rivers belonging to different basins while the second deals with the perimeter line not respecting the hydrographic network. The GIS analysis results clearly show that ZITT boundary is cartographically nonsense due to the impossibility of mapping out the perimeter. Furthermore, GIS analysis of anthropological data shows presence of Tagaeri Taromenane clans outside the ZITT perimeter, within oil production areas and in nearby farmer settlements, reflecting the limits of protection policies for non-contacted indigenous territory. The delimitation of the ZITT followed a traditional pattern of geometric boundary not taking into account the nomadic characteristic of Tagaeri Taromenane: it is necessary to adopt geographical approaches to recognize the indigenous right to their liveable territories in the complex territorialities enacted by different stakeholders. PMID:23840436

Pappalardo, Salvatore Eugenio; De Marchi, Massimo; Ferrarese, Francesco

2013-01-01

88

Instantánea del cáncer infantil  

Cancer.gov

Información sobre la incidencia y mortalidad del cáncer en los niños, tendencias en el financiamiento del NCI para la investigación del cáncer infantil; así como ejemplos de actividades y adelantos en la investigación relevantes para esta población.

89

Atlas del Genoma del Cáncer: Antecedentes  

Cancer.gov

El Atlas del Genoma del Cáncer es una iniciativa de los Institutos Nacionales de la Salud (NIH) para crear mapas multidimensionales completos de los cambios genómicos clave en los tipos y subtipos principales de cáncer.

90

Canine zona pellucida glycoprotein-3: Up-scaled production, immunization strategy and its outcome on fertility.  

PubMed

Zona pellucida (ZP) glycoproteins based contraceptive vaccines have been proposed for the management of wildlife population. In the present study, a fusion protein encompassing promiscuous T cell epitope of tetanus toxoid [TT; amino acid (aa) residues 830-844] followed by a dilysine linker and an ectodomain of dog ZP3 (ZP3; aa residues 23-348) without any affinity tag (TT-KK-ZP3) has been expressed in Escherichia coli. The recombinant protein was successfully produced in fed-batch fermentor and purified. The average yield of purified refolded protein was 12.20±0.61mg/2g wet cell pellet. Female FvB/J mice immunized with the varying doses of recombinant TT-KK-ZP3 supplemented with alum/PetGel A as adjuvants following a three injection schedule, showed dose dependent increase in serum IgG titer. Antibodies against TT-KK-ZP3 recognized native mouse/dog ZP and significantly inhibited mouse in-vitro fertilization (p=0.012). Immunized mice showed significant reduction in fertility (p<0.05). Higher antibody titers were associated with a decrease in the number of pups born to the immunized female mice. To reduce the number of injections, two injection schedule using various dose combinations of TT-KK-ZP3 supplemented with alum revealed lower immunogenicity and contraceptive efficacy as compared to the three injection schedule. To overcome this, CpG motif was included in addition to alum and both intraperitoneal and intranasal route of immunization following the two injection schedule was investigated. Inclusion of CpG significantly enhanced the antibody titer and improved contraceptive efficacy. In the mice immunized following intraperitoneal route, serum/vaginal IgG and in the mice immunized through intranasal route, vaginal IgA seemed to be important for curtailment in fertility. To conclude, the recombinant protein described herein may be a good candidate for developing contraceptive vaccine for the wildlife population management, in particular street dogs. PMID:25448113

Shrestha, Abhinav; Srichandan, Sudeepa; Minhas, Vidisha; Panda, Amulya Kumar; Gupta, Satish Kumar

2015-01-01

91

Calcium-free vitrification reduces cryoprotectant-induced zona pellucida hardening and increases fertilization rates in mouse oocytes.  

PubMed

Despite the success of embryo cyropreservation, routine oocyte freezing has proved elusive with only around 200 children born since the first reported birth in 1986. The reason for the poor efficiency is unclear, but evidence of zona pellucida hardening following oocyte freezing indicates that current protocols affect oocyte physiology. Here we report that two cryoprotectants commonly used in vitrification procedures, dimethyl sulfoxide (DMSO) and ethylene glycol, cause a large transient increase in intracellular calcium concentration in mouse metaphase II (MII) oocytes comparable to the initial increase triggered at fertilization. Removal of extracellular calcium from the medium failed to affect the response exacted by DMSO challenge, but significantly reduced the ethylene glycol-induced calcium increase. These results suggest that the source of the DMSO-induced calcium increase is solely from the internal calcium pool, as opposed to ethylene glycol that causes an influx of calcium across the plasma membrane from the external medium. By carrying out vitrification in calcium-free media, it was found that zona hardening is significantly reduced and subsequent fertilization and development to the two-cell stage significantly increased. Furthermore, such calcium-free treatment appears not to affect the embryo adversely, as shown by development rates to the blastocyst stage and cell number/allocation. Since zona hardening is one of the early activation events normally triggered by the sperm-induced calcium increases observed at fertilization, it is possible that other processes are negatively affected by the calcium rise caused by cryoprotectants used during oocyte freezing, which might explain the current poor efficiency of this technique. PMID:16388009

Larman, Mark G; Sheehan, Courtney B; Gardner, David K

2006-01-01

92

Molecular characterization and expression pattern of three zona pellucida 3 genes in the Chinese sturgeon, Acipenser sinensis  

Microsoft Academic Search

Chinese sturgeon (Acipenser sinensis) is a rare and endangered species and also an important resource for the sturgeon aquaculture industry. SMART cDNAs were\\u000a synthesized from the ovary of A. sinensis, and the full-length cDNAs of three zona pellucida glycoprotein 3 genes (the new gene named AsZP3) were cloned and sequenced. AsZP3.1, AsZP3.2, and AsZP3.3 were 1,388 base pairs (bp), 1,288,

Li Chuang-Ju; Wei Qi-Wei; Chen Xi-Hua; Zhou Li; Cao Hong; Gan Fang; Gui Jian-Fang

2011-01-01

93

Incidence of anti-zona pellucida and anti-sperm antibodies among infertile Jordanian women and its relation to mycoplasmas.  

PubMed

Anti-zona-pellucida autoantibodies (AZP-Ab) and anti-sperm isoantibodies (ASA) were assessed in the cervical secretions from 73 infertile Jordanian women and 41 fertile control women using latex agglutination. Significantly more women with infertility had AZP-Ab and ASA (16.4% and 8.2% respectively) compared with fertile women (9.4% and 0%), with no relation to the etiology of infertility. Using polymerase chain reaction Mycoplasma hominis and Ureaplasma urealyticum were detected in cervical secretions of 19.2% and 13.7% of infertile women, and the presence of mycoplasma was significantly correlated with the presence of AZP-Ab and ASA. PMID:20214140

Al-Daghistani, H I; Fram, K M

2009-01-01

94

Effect of preincubation of human spermatozoa in milk on penetration of zona-free hamster oocytes: Comparison to TEST yolk  

Microsoft Academic Search

Purpose  \\u000a To investigate the effect of preincubation of human sperm in milk on their ability to penetrate zona-free hamster oocytes,\\u000a 27 ejaculates were studied. Each ejaculate was divided into two portions and incubated in either milk or TEST yolk (TESTY)\\u000a for 22–24 hr at 5‡C prior to processing for the sperm penetration assay.\\u000a \\u000a \\u000a \\u000a Results  \\u000a Spermatozoa preincubated in milk penetrated a

M. Joseph Scobey; Wendy J. Holmgren; Rajasingam S. Jeyendran

1994-01-01

95

Políticas del sitio web  

Cancer.gov

En el sitio web del NCI se proporcionan enlaces a otros sitios web con fines informativos y para conveniencia del público. Si el usuario selecciona un sitio web externo, saldrá del sitio web del NCI y estará sujeto a las políticas de privacidad y seguridad de dicho sitio.

96

Assessment of Mouse Germinal Vesicle Stage Oocyte Quality by Evaluating the Cumulus Layer, Zona Pellucida, and Perivitelline Space  

PubMed Central

To improve the outcome of assisted reproductive technology (ART) for patients with ovulation problems, it is necessary to retrieve and select germinal vesicle (GV) stage oocytes with high developmental potential. Oocytes with high developmental potential are characterized by their ability to undergo proper maturation, fertilization, and embryo development. In this study, we analyzed morphological traits of GV stage mouse oocytes, including cumulus cell layer thickness, zona pellucida thickness, and perivitelline space width. Then, we assessed the corresponding developmental potential of each of these oocytes and found that it varies across the range measured for each morphological trait. Furthermore, by manipulating these morphological traits in vitro, we were able to determine the influence of morphological variation on oocyte developmental potential. Manually altering the thickness of the cumulus layer showed strong effects on the fertilization and embryo development potentials of oocytes, whereas manipulation of zona pellucida thickness effected the oocyte maturation potential. Our results provide a systematic detailed method for selecting GV stage oocytes based on a morphological assessment approach that would benefit for several downstream ART applications. PMID:25144310

Liu, Ying-Lei; Chen, Ying; Zhou, Cheng-Jie; Wu, Sha-Na; Shen, Jiang-Peng; Liang, Cheng-Guang

2014-01-01

97

Cupulin Is a Zona Pellucida-Like Domain Protein and Major Component of the Cupula from the Inner Ear  

PubMed Central

The extracellular membranes of the inner ear are essential constituents to maintain sensory functions, the cupula for sensing torsional movements of the head, the otoconial membrane for sensing linear movements and accelerations like gravity, and the tectorial membrane in the cochlea for hearing. So far a number of structural proteins have been described, but for the gelatinous cupula precise data are missing. Here, we describe for the first time a major proteinogenic component of the cupula structure with an apparent molecular mass of 45 kDa from salmon. Analyses of respective peptides revealed highly conserved amino-acid sequences with identity to zona pellucida-like domain proteins. Immunohistochemistry studies localized the protein in the ampulla of the inner ear from salmon and according to its anatomical appearance we identified this glycoprotein as Cupulin. Future research on structure and function of zona pellucida-like domain proteins will enhance our knowledge of inner ear diseases, like sudden loss of vestibular function and other disturbances. PMID:25369234

Dernedde, Jens; Weise, Christoph; Müller, Eva-Christina; Hagiwara, Akira; Bachmann, Sebastian; Suzuki, Mamoru; Reutter, Werner; Tauber, Rudolf; Scherer, Hans

2014-01-01

98

Instantánea del cáncer colorrectal  

Cancer.gov

Información sobre las tendencias de incidencia, mortalidad y financiamiento del NCI sobre el cáncer colorrectal; así como ejemplos de actividades del NCI y adelantos en la investigación de este tipo de cáncer.

99

Perceived articulatory precision in patients with Parkinson's disease after deep brain stimulation of subthalamic nucleus and caudal zona incerta.  

PubMed

Abstract The effect of deep brain stimulation (DBS) of the subthalamic nucleus (STN) and caudal zona incerta (cZi) on speech articulation in patients with Parkinson's disease (PD) was investigated. Read speech samples were collected from nine patients with STN-DBS and 10 with cZi-DBS. The recordings were made pre-operatively and 12 months post-operatively with stimulator on and off (on medication). Blinded, randomised, repeated perceptual assessments were performed on words and isolated fricatives extracted from the recordings to assess (1) overall articulatory quality ratings, (2) frequency of occurrence of misarticulation patterns and (3) fricative production. Statistically significant worsening of articulatory measures on- compared with off-stimulation occurred in the cZi-DBS group, with deteriorated articulatory precision ratings, increased presence of misarticulations (predominately altered realisations of plosives and fricatives) and a reduced accuracy in fricative production. A similar, but not significant, trend was found for the STN-DBS group. PMID:25333411

Eklund, Elisabeth; Qvist, Johanna; Sandström, Lena; Viklund, Fanny; Van Doorn, Jan; Karlsson, Fredrik

2015-02-01

100

Productividad primaria del fitoplancton en la zona eufótica del Sistema de la Corriente de California estimada mediante imágenes del CZCS Phytoplankton primary productivity in the euphotic zone of the California Current System estimated from CZCS imagery  

Microsoft Academic Search

We estimated phytoplankton primary productivity (PP) in the euphotic zone of the California Current System using chlorophyll concentration (Chl) from CZCS imagery. The area was divided into two regions, Southern California (SC) and Baja California (BC), with inshore and offshore subregions, and into two seasons, cool and warm. The Chl and PP values were in general higher and more variable

OA Barocio-León; R Millán-Núñez; E Santamaría-del-Ángel; A González-Silvera

101

Nunca deje alimentos en la zona peligrosa (temperaturas entre 40 F) por ms de 2 horas. Las bacterias se multiplican rpidamente  

E-print Network

Nunca deje alimentos en la zona peligrosa (temperaturas entre 40° F y 140° F) por más de 2 horas. Las bacterias se multiplican rápidamente en los alimentos que están en estas temperaturas. Las temperaturas apropiadas en el refrigerador y el congelador ayudan a conservar los alimentos en buen estado y

102

RACEMIZATION OF METEORITIC AMINO ACIDS. B. A. Cohen1 and C. F. Chyba, The University of Ari-zona, Tucson AZ 85719 1bcohen@lpl.arizona.edu.  

E-print Network

RACEMIZATION OF METEORITIC AMINO ACIDS. B. A. Cohen1 and C. F. Chyba, The University of Ari- zona, Tucson AZ 85719 1bcohen@lpl.arizona.edu. Amino acids are the building blocks of proteins, among the most biologically critical molecules. It was first noted in the 1800's that the vast majority of amino acids used

Cohen, Barbara Anne

103

Effect of oocyte quality and sperm characteristics on the number of spermatozoa bound to the zona pellucida of human oocytes inseminated in vitro  

Microsoft Academic Search

Sperm characteristics and oocyte quality may play a role in in vitro fertilization. The objective of this paper is to analyze the effect of the quality of oocytes, the husband's semen characteristics, and category of the couple's infertility on the number of spermatozoa bound to the zona pellucida. One hundred eightyone oocytes which failed to fertilize or failed to cleave

Maha M. Mahadevan; Alan O. Trounson; Carl Wood; John F. Leeton

1987-01-01

104

The impact of the zona pellucida thickness variation of human embryos on pregnancy outcome in relation to suboptimal embryo development. A prospective randomized controlled study  

Microsoft Academic Search

BACKGROUND: The study represents a prospective randomized controlled study evaluating zona pellucida thickness variation (ZPTV) measurements versus conventional selection of embryos using classic embryo score criteria, prior to embryo transfer in human IVF\\/intracytoplasmatic sperm injection (ICSI). METHODS: Eighty- six patients having ?3 embryos, with a classic embryo score of ?2.2, were allocated to either ZPTV measurement or classic embryo morphology

A. Gabrielsen; S. Lindenberg; K. Petersen

2001-01-01

105

Calcium influx into mouse spermatozoa activated by solubilized mouse zona pellucida, monitored with the calcium fluorescent indicator, fluo-3. Inhibition of the influx by three inhibitors of the zona pellucida induced acrosome reaction: tyrphostin A48, pertussis toxin, and 3-quinuclidinyl benzilate.  

PubMed

The fluorescent calcium indicator, fluo-3, was loaded as the membrane permeant tetraacetoxymethyl (AM) ester into cauda epididymal mouse sperm at 25 degrees C for 20 min in the absence of bovine serum albumin (BSA) and presence of the dispersant, Pluronic F-127. Excess indicator was removed by two centrifugation washes at 100g for 10 min, a procedure that did not impair sperm motility. Upon resuspension in medium containing 20 mg/ml BSA to promote capacitation, the sperm cells exhibited readily detectable fluorescence uniformly distributed in the cytoplasm. Cell fluorescence was stable over the time of the experiments and was responsive to changes in intracellular calcium concentration, [Ca2+]i. Initial [Ca2+]i was 231 +/- 58 nM (+/- SE, n = 43). Addition of heat-solubilized mouse zonae pellucidae to capacitated sperm increased [Ca2+]i by 106 +/- 19 nM (+/- SE, n = 18), the higher steady-state concentration being reached after 30 min. Subsequent addition of the non-fluorescent calcium ionophore Br-A23187 resulted in a further increase of 114 +/- 18 nM (+/- SE, n = 18), the higher steady-state concentration being reached after 6 min. The increase in [Ca2+]i induced by solubilized zonae pellucidae was largely blocked by 3-quinuclidinyl benzilate (QNB), an antagonist of muscarinic receptors that was earlier shown to block the zona pellucida induced acrosome reaction in mouse sperm (Florman and Storey, 1982: Dev Biol 91:121-130). This [Ca2+]i increase was completely blocked by the tyrosine kinase inhibitor, tyrphostin A48, and by the inactivator of G1 proteins, pertussis toxin. At the concentrations at which they blocked the zona pellucida-induced increase in [Ca2+]i, all three inhibitors also blocked the zona pellucida-induced acrosome reaction. These results indicate that [Ca2+]i increase in is an early, if not the initial, reaction in the sequence leading to zona pellucida induced acrosomal exocytosis in mouse sperm. The observation that the three inhibitors, each having a different mode of action, all block the zona pellucida induced [Ca2+]i suggests that the sperm plasma membrane receptors mediating the zona pellucida induced acrosome reaction may function as a complex, whose formation is activated by zona pellucida ligand binding. PMID:7888169

Bailey, J L; Storey, B T

1994-11-01

106

Prevalencia de sibilancias en la población de niños menores de 15 años de edad de la zona urbana del municipio de Boca Chica  

Microsoft Academic Search

We'representing the resultofa prospective Investlgactlon made In and urban zone of Boca Chica. It's purpose was to know about the wheezlng prevalence in chlldren under 6 years old. The 267 children test Informatlons reveals a prevalence of 15.0% of wheezlng with an above frequency for male suspects. The 51.3% had background In a period of their l\\/ves and the most

Encarnación Casanova; Daysi Hernández; Maritza Lara; Julia Quezada; Dra. Leidy; Damaris Medina De

107

Festival del Sur '98  

E-print Network

andaluz dedicándole una noche temática con dos espectáculos, el de los cubanos Galiano 108 Federico-La Habana-Lorca y el del chileno Franklin Caicedo Lorca y sus amigos poetas; asimismo, se proyectaron varios vídeos sobre su vida y montajes emblemáticos... a veces hacían difícil la comprensión del texto. Todo ello redundó en crear una atmósfera asfixiante y la repulsión del público ante esta lucha entre los sexos y las clases sociales. Desde Bolivia vino Amalilef Teatro con Jamás diré adiós, un...

Má rquez Montes, Carmen

1999-04-01

108

High-frequency stimulation of both zona incerta and subthalamic nucleus induces a normalization of basal ganglia metabolic activity in experimental parkinsonism  

Microsoft Academic Search

High-frequency stimulation (HFS) of the subthalamic nucleus (STN) alleviates dramatically motor symptoms in Parkinson's disease, and recently it has been suggested that zona incerta (ZI) stimulation might be as beneficial to patients. We used in situ cytochrome oxidase (CoI) mRNA hybridization to investigate and compare the effects of HFS of the STN and the ZI on metabolic activity of the

Abdelhamid Benazzouz; Chun Hwei Tai; Wassilios Meissner; Bernard Bioulac; Erwan Bezard; Christian Gross

2004-01-01

109

Lewis X-Containing Neoglycoproteins Mimic the Intrinsic Ability of Zona Pellucida Glycoprotein ZP3 to Induce the Acrosome Reaction in Capacitated Mouse Sperm1  

Microsoft Academic Search

The binding of zona pellucida (ZP) glycoprotein ZP3 to mouse sperm surface receptors is mediated by protein-carbo- hydrate interactions. Subsequently, ZP3 induces sperm to un- dergo the acrosome reaction, an obligatory step in fertilization. We have previously identified Lewis X (Le x ; Galb4(Fuca3) GlcNAc) as a potent inhibitor of in vitro sperm-ZP binding (Johnston et al. J Biol Chem

William F. Hanna; Candace L. Kerr; Joel H. Shaper; William W. Wright

110

Quantification of rainbow trout ( Oncorhynchus mykiss) zona radiata and vitellogenin mRNA levels using real-time PCR after in vivo treatment with estradiol-17? or ?-zearalenol  

Microsoft Academic Search

Estrogen receptor-mediated induction of zona radiata (ZR) and vitellogenin (VTG) mRNA and protein in rainbow trout (Oncorhynchus mykiss) was compared to assess their utility as biomarkers for exposure to estrogenic compounds. Partial sequences of rainbow trout ZR and ?-actin were cloned by reverse transcriptase polymerase chain reaction (RT-PCR) using degenerate primers based on conserved regions across a number of species.

Trine Celius; Jason B. Matthews; John P. Giesy; Timothy R. Zacharewski

2000-01-01

111

Transformaciones del Estado y del Derecho  

Microsoft Academic Search

El concepto de derecho asentado en la mentalidad jurídica actual responde a un modelo profundamente “estatista”, racional y formal. Sus premisas se construyen de acuerdo con las estructuras y los discursos políticos que se desarrollan durante las postrimerías de la Edad Moderna en Europa y triunfa definitivamente con las revoluciones burguesas. Las formas jurídicas desarrolladas como fundamento y sostén del

Manuel Calvo García

112

TEORÍAS DEL DESARROLLO A PRINCIPIOS DEL SIGLO XXI  

Microsoft Academic Search

1 La evolución de las ideas no sigue el curso de los siglos. Es más, en el transcurso del siglo XX hemos presenciado cambios radicales en lo que a teoría del desarrollo se refiere. Ni siquiera es indispensable definir los siglos de acuerdo con la clasificación del calendario, de cero a noventa y nueve. En su célebre discurso del 8

AMARTYA SEN

113

Roles of GABAA and GABAB receptors in regulating thalamic activity by the zona incerta: a computational study.  

PubMed

The posterior thalamic nucleus (PO) is a higher order nucleus heavily implicated in the processing of somatosensory information. We have previously shown in rodent models that activity in PO is tightly regulated by inhibitory inputs from a GABAergic nucleus known as the zona incerta (ZI). The level of incertal inhibition varies under both physiological and pathological conditions, leading to concomitant changes in PO activity. These changes are causally linked to variety of phenomena from altered sensory perception to pathological pain. ZI regulation of PO is mediated by GABAA and GABAB receptors (GABAAR and GABABR) that differ in their binding kinetics and their electrophysiological properties, suggesting that each may have distinct roles in incerto-thalamic regulation. We developed a computational model to test this hypothesis. We created a two-cell Hodgkin-Huxley model representing PO and ZI with kinetically realistic GABAAR- and GABABR-mediated synapses. We simulated spontaneous and evoked firing in PO and observed how these activities were affected by inhibition mediated by each receptor type. Our model predicts that spontaneous PO activity is preferentially regulated by GABABR-mediated mechanisms, while evoked activity is preferentially regulated by GABAAR. Our model also predicts that modulation of ZI firing rate and synaptic GABA concentrations is an effective means to regulate the incerto-thalamic circuit. The coupling of distinct functions to GABAAR and GABABR presents an opportunity for the development of therapeutics, as particular aspects of incerto-thalamic regulation can be targeted by manipulating the corresponding receptor class. Thus these findings may provide interventions for pathologies of sensory processing. PMID:25143541

Park, Anthony; Hoffman, Kathleen; Keller, Asaf

2014-11-15

114

Molecular characterization and expression pattern of three zona pellucida 3 genes in the Chinese sturgeon, Acipenser sinensis.  

PubMed

Chinese sturgeon (Acipenser sinensis) is a rare and endangered species and also an important resource for the sturgeon aquaculture industry. SMART cDNAs were synthesized from the ovary of A. sinensis, and the full-length cDNAs of three zona pellucida glycoprotein 3 genes (the new gene named AsZP3) were cloned and sequenced. AsZP3.1, AsZP3.2, and AsZP3.3 were 1,388 base pairs (bp), 1,288, and 1,290 bp in length, respectively, and they could be translated into proteins with 440, 394, and 398 amino acids, respectively. High level of amino acids sequence identity was seen between AsZP3.2 and AsZP3.3 (about 82%), but they share low identity with AsZP3.1 (26 and 23%, respectively). The AsZP3.1 has 42-50% amino acids sequence identity values with other fish and lower values with higher vertebrates (38%); AsZP3.2 and AsZP3.3 shared about 30-44% sequence identity with higher vertebrates and other fish. RT-PCR analysis indicated that AsZP3.1 displayed a wide tissue distribution at the mRNA levels including liver, kidney, spleen, heart, and ovary, but AsZP3.2 and AsZP3.3 mRNAs were expressed exclusively in the gonad. All three AsZP3 mRNAs were not detected during embryogenesis and early larval development; furthermore, they were not detected in the gonads of 1- and 2-year-old Chinese sturgeons. All three AsZP3 mRNAs were detected in the testes of 3-year-old males and in the ovaries of 4- and 5-year-old female Chinese sturgeons. PMID:21072685

Chuang-Ju, Li; Qi-Wei, Wei; Xi-Hua, Chen; Li, Zhou; Hong, Cao; Fang, Gan; Jian-Fang, Gui

2011-09-01

115

Does women’s age influence zona pellucida birefringence of metaphase ?? oocytes in in-vitro maturation program?  

PubMed Central

Background: In vitro maturation (IVM) is a promising treatment option for certain infertile women. Nowadays, with the aid of PolScope, it has become possible to evaluate zona pellucida (ZP) characteristics as a parameter of oocyte quality. Moreover, quality of oocytes can be influenced by many factors, such as patient’s age. The PolScope system is a non-invasive technique to assess birefringent structures such as the meiotic spindle and ZP in living oocytes. Objective: The aim was to determine the influence of the woman's age on ZP birefringence, a sign of oocyte quality, and morphology of in-vitro matured human oocytes using non-invasive polarized light (PolScope) microscopy. Materials and Methods: ZP birefringence and morphology were determined in 105 retrieved oocytes from 58 women undergoing ICSI in two age groups (?30 years and <30 years). The immature oocytes were selected and after IVM, the quality of metaphase ?? (MII) oocytes was assessed. The oocytes abnormalities were classified as intracytoplasmic and extracytoplasmic abnormalities. Results: Oocyte maturation rates were significantly reduced in ?30 year’s women (56%) in comparison with other age group (80.7%). In addition, the ZP birefringence was significantly higher in MII oocytes in the younger group compared with the older group (76.2% vs. 38.1%; p=0.00). Following morphologic assessment, the rates of oocytes with extracytoplasmic (p=0.02) and both abnormalities (extra- and intracytoplasmic) (p=0.01) were higher in aged versus the younger women. Conclusion: There was a positive relationship between advanced maternal age with decreased ZP birefringence and oocyte morphological quality in in-vitro matured human oocytes. PMID:24639703

Omidi, Marjan; Khalili, Mohammad Ali; Nahangi, Hossein; Ashourzadeh, Sareh; Rahimipour, Marzieh

2013-01-01

116

Hojas informativas del NCI  

Cancer.gov

La colección de hojas informativas del NCI trata de una variedad de temas relacionados con el cáncer. Las hojas informativas se revisan y ponen al día de acuerdo a las investigaciones más recientes sobre el cáncer.

117

en Fisioterapia del Deporte  

E-print Network

Experto en Fisioterapia del Deporte III Edición RESERVA DE PLAZAY MATRÍCULA Título: Experto en Fisioterapia del Deporte Precio de título: 1.800 Plazo de preinscripción: hasta 15 de Octubre 2014 Nº de: TRATAMIENTO DE LA LESI�N DEPORTIVA EN AGUA BLOQUEV: TERAPIAS MANUALES APLICADAS AL DEPORTE BLOQUEVI: PUNCI�N

Rey Juan Carlos, Universidad

118

Control del cáncer y salud mundial: noticia del Instituto Nacional del Cáncer (NCI)  

Cancer.gov

En combinación con una reunión de alto nivel de las Naciones Unidas sobre enfermedades no transmisibles en países en vías de desarrollo, el doctor Harold Varmus, director del NCI, y el doctor Ted L. Trimble, del NCI, han publicado un comentario en Science Translational Medicine sobre “La integración del control del cáncer en la salud mundial" (Integrating Cancer Control into Global Health).

119

Zona Land: Energy  

NSDL National Science Digital Library

This item is a tutorial on work and energy designed and maintained by a high school physics teacher. Topics include kinetic and potential energy, spring potential energy, GPE, heat and temperature, and nuclear energy. The author uses an entertaining blend of text and interactive simulations to engage the student. NOTE: The full potential of this resource cannot be viewed without a VRML plug-in. This item is part of a larger collection of physics and mathematics resources by the author.

Zobel, Edward

2007-10-23

120

Zona Land: Waves  

NSDL National Science Digital Library

This item is a tutorial on the fundamentals of waves. Topics include wave properties and phenomena, types of waves, wave interference, and more. The section on interference includes simple animations of constructive and destructive interference, which can be played in slow motion to allow users to visualize the phenomena before attempting more difficult wave simulations.

Zobel, Edward

2009-03-22

121

Zona Land: Standing Waves  

NSDL National Science Digital Library

This is a tutorial for high school physics students on the topic of standing waves. It is a highly visual exploration of the topic and includes a brief text explanation of the phenomenon and a set of 16 static diagrams illustrating node and antinode locations for the 1st-5th harmonic. Students may also interactively explore simulations of standing waves on a violin (both ends fixed), a flute (both ends open), and a thumb piano (one end fixed, one end open). This item is part of a larger collection of tutorials developed by the author on a broad range of topics in physics and mathematics.

Zobel, Edward

2009-03-28

122

EL ESTUDIO DEL PLUMBISMO EN DOANA Y OTROS HUMEDALES ANDALUCES  

E-print Network

Doñana y otras zonas principales de invernada..............51 4.1- Introducción .................................................................................................66 5.1- Introducción

Figuerola, Jordi

123

Inoculation of female American black bears (Ursus americanus) with partially purified porcine zona pellucidae limits cub production.  

PubMed

The present 2-year study investigated the feasibility of using porcine zona pellucidae (pZP) as antigen for immunocontraception in American black bears. Sows, 3-6 years of age, were administered either two doses of 250 microg pZP with Freund's adjuvant (n = 10) or adjuvant alone (n = 5), one in April and one in May, and were kept away from the boars until June. Serum samples were collected before injections and before denning (November). The presence of sows with cubs at side was observed during premature emergence from denning. First-year results indicated that anti-pZP antibody titres in vaccinated sows were 2.5-9.0-fold (range) higher compared with non-vaccinated sows and that the vaccinated sows were threefold less likely to become pregnant (P = 0.167). Control and vaccinated bears produced 1.6 and 0.2 cubs per sow, respectively (P = 0.06). The second-year study investigated the feasibility of using pZP sequestered in a controlled-release pellet and a water-soluble adjuvant (QS-21) to avoid regulatory problems associated with Freund's adjuvant. Sows in the treatment group (n = 22) were administered a single dose of an emulsion of 250 microg pZP and 150 microg QS-21 plus a pellet containing 70-90 microg pZP for delayed release as booster dose. Control sows (n = 5) received the QS-21 adjuvant in pellet alone. Serum samples were collected before inoculations (April) and before denning (November). Seven cubs were born to the five control sows, but none was born to the 22 vaccinated sows (P < 0.001). Anti-pZP antibody mean absorbance ratios in control sows remained at background levels, whereas vaccinated sows had ratios fourfold higher than controls. Two-dimensional polyacrylamide gel electrophoresis and immunohistochemical localisation confirmed immunoreactivity of sera from inoculated bears. We conclude that cub production in the American black bear can be effectively limited with either two injections of 250 microg pZP or a single inoculation of partially purified pZP sequestered in controlled-release pellets. PMID:17601409

Lane, V M; Liu, I K M; Casey, K; vanLeeuwen, E M G; Flanagan, D R; Murata, K; Munro, C

2007-01-01

124

Single-treatment porcine zona pellucida immunocontraception associated with reduction of a population of white-tailed deer (Odocoileus virginianus).  

PubMed

Previous reports have demonstrated gradual reductions of white-tailed deer (Odocoileus virginianus) populations through immunocontraception, with stabilization occurring after 2-4 yr of treatment, and subsequent reductions of 6-10% annually. These studies employed porcine zona pellucida (PZP) vaccines that required two initial treatments and annual retreatments. From 2005 to 2010, 258 adult and yearling female deer on Fripp Island, South Carolina, were treated with one of several PZP preparations designed to produce 2+ yr of effective contraception with a single treatment. These included several preparations of SpayVac and of native PZP-adjuvant emulsion plus PZP and QA-21 in timed-release pellets. Deer were chemically immobilized, ear-tagged, and administered initial treatments by hand in February-March. Some treated deer were boosted remotely with PZP-adjuvant emulsion 1.5 - 4.5 yr after initial treatments. Ground-based distance sampling was used to estimate deer population density at Fripp Island, a resort community, and at a relatively undeveloped neighboring control site, Hunting Island. Most vaccine preparations tested reduced fawning rates by 75% to 95% for at least 1 yr. From 2005 to 2011, deer density on Fripp Island declined by 50%, from 72 deer/km(2) to 36 deer/km(2), an average annual reduction of 11%. In contrast, population density on the Hunting Island control site fluctuated between 2005 and 2011, averaging 23 deer/km(2) (range, 19-28 deer/km(2)). Population declines on Fripp Island were associated with an increase in the proportion of treated females and with a progressive decrease in winter fawn:doe ratios, from 1.21 fawns/doe in 2005 to 0.19 fawns/doe in 2010. Winter fawn:doe ratios averaged 1.36 fawns/doe (range, 0.84 - 1.62 fawns/doe) at the Hunting Island control site. Annual survivorship averaged approximately 79% among ear-tagged females. The rate at which deer populations diminished in association with PZP treatments on Fripp Island was higher than that seen at other study sites, although the reasons for the more rapid decline on Fripp Island are not well understood. PMID:24437087

Rutberg, Allen T; Naugle, Ricky E; Verret, Frank

2013-12-01

125

Cryopreservation reduces the ability of equine spermatozoa to attach to oviductal epithelial cells and zonae pellucidae in vitro.  

PubMed

Two bioassays were used to evaluate the interaction of fresh and cryopreserved equine semen with oviductal epithelial cells (OEC) and with the zona pellucida (ZP). Split ejaculates were either stored at room temperature or frozen and thawed. In experiment 1, progressive motility and membrane integrity were evaluated for each treatment. Fluorescent labeled spermatozoa were cocultured with monolayers of OEC for 30 minutes, and the number of sperm attached to OEC was counted by fluorescence microscopy and analysis of digitized images. Motility of spermatozoa attached to OEC was observed at 0.5, 3, 6, 18, 24, and 48 hours after insemination. In experiment 2, progressive motility, membrane integrity, and acrosomal integrity were determined. Differential labeling with the fluorochromes fluorescein isothiocyanate (FITC) or tetramethylrhodamine isothiocyanate (TRITC) was used to distinguish fresh and frozen-thawed spermatozoa. Equal numbers of motile spermatozoa from each treatment were incubated with salt-stored equine oocytes for 4 hours, and the number of spermatozoa firmly bound to the ZP was counted using dual-wavelength epifluorescence microscopy. Fewer (P < 0.001) cryopreserved spermatozoa attached to OEC compared to spermatozoa stored at room temperature. The motility of spermatozoa attached to OEC decreased over time within each treatment group (P < 0.001), but this decrease was not different between treatments. The mean number of spermatozoa bound per ZP and percentage of acrosome-intact spermatozoa were lower (P < 0.05) for frozen-thawed than for fresh spermatozoa. There was no effect of stallion on acrosomal status of frozen-thawed spermatozoa; however, the number of spermatozoa bound per ZP was different between stallions within treatments (P < 0.05). These results indicate that the ability of cryopreserved equine spermatozoa to attach to equine OEC or ZP in vitro is reduced compared to fresh extended spermatozoa due to changes other than a reduction in post-thaw motility or membrane integrity. The decreased ability of frozen-thawed spermatozoa to attach to OEC or to ZP could explain, in part, the reduced fertility of cryopreserved compared to fresh spermatozoa in the horse. PMID:8867602

Dobrinski, I; Thomas, P G; Ball, B A

1995-01-01

126

Coculturing cumulus oocyte complexes with denuded oocytes alters zona pellucida ultrastructure in in vitro matured bovine oocytes.  

PubMed

Oocyte quality is a key factor affecting success of in vitro embryo production in cattle. Improving the microenvironment of oocytes during in vitro maturation (IVM) can increase developmental rate and embryo quality. Therefore, the objective was to determine whether denuded oocytes (DO) affect embryo development and ultrastructure of the zona pellucida (ZP) in in vitro matured bovine oocytes. Intact immature cumulus-oocytes complexes (COC) obtained from a local abattoir or by ovum pick-up (OPU) were cocultured with and without abattoir-obtained DO at a COC:DO ratio of 1:5. After IVM, DO were removed and intact DO were either fertilized or observed by scanning electron microscopy. Blastocyst quality was evaluated using a TUNEL assay. The ZP pore size decreased after IVM in COC + DO coculture, regardless of their origin (OPU, 310.5 ± 92.5 vs. 428.9 ± 148.5 nm; abattoir, 317.5 ± 68.5 vs. 358.9 ± 128.5 nm; P < 0.05; mean values ± standard deviation). Moreover, the number of ZP pores in OPU COC + DO and COC + DO was greater than those in OPU COC and COC (control) groups (56 ± 4 and 55 ± 7 vs. 50 ± 6 and 42 ± 4; P < 0.05). The rate of blastocyst development in COC + DO and OPU COC + DO groups was greater those in control and OPU COC groups (36.6% and 55.5% vs. 28.1% and 40.0%; P < 0.05). Moreover, the total cell numbers of blastocysts in COC + DO group exceeded that of control (132.91 ± 30.90 vs. 115.44 ± 24.95; P < 0.05), with no significant between OPU COC + DO and OPU COC groups (139.31 ± 42.51 vs. 137.00 ± 61.34). In conclusion, in vitro embryo development competence and quality improved when oocytes were cocultured with DO. Furthermore, there more, but smaller, ZP pores. PMID:24084231

Choi, Byung-Hyun; Bang, Jae-Il; Jin, Jong-In; Kim, Seong-Su; Jo, Hyun-Tae; Deb, Gautam Kumar; Ghanem, Nasser; Cho, Kyu-Woan; Kong, Il-Keun

2013-12-01

127

Damage of zona pellucida reduces the developmental potential and quality of porcine circovirus type 2-infected oocytes after parthenogenetic activation.  

PubMed

The present aimed to study if porcine circovirus type 2 (PCV2), which adhered to zona pellucida (ZP), was able to enter mature porcine oocytes with intact and damaged ZP. Four groups, including uninfected ZP-intact oocytes (UOZI), uninfected ZP-damaged oocytes (UOZD), PCV2-infected ZP-intact oocytes (POZI), and PCV2-infected ZP-damaged oocytes (POZD) were studied. The oocytes were incubated with 1 mL minimum essential medium, containing 3.1 × 10(8) copies of PCV2 DNA for 1 hour. Mechanical procedure of the insertion by microneedle induced injuries to the ZP of porcine oocytes. At the blastocyst stage, the percentage of PCV2-infected embryos and the ratio of viral antigen-positive cells per embryo were determined by indirect immunofluorescence. To assess the effect of ZP injury on the developmental competence and quality of porcine PCV2-infected oocytes after parthenogenetic activation, blastocyst formation rates and terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick-end labeling staining were analyzed. Moreover, real-time polymerase chain reaction was used to evaluate the expression of genes related to apoptosis and pluripotency at different developmental stages. The results of indirect immunofluorescence showed that only POZD group presented PCV2-infected embryos and viral-positive cells. The blastocyst rate of POZD group dropped down to approximately half of POZI group's (7.1 ± 1.5 vs. 14.5 ± 3.3). At the blastocyst stage, ZP injury increased apoptotic index of PCV2-infected embryos. The relative expression levels of Caspase 3 were higher in POZD group than the ones in POZI group at the two- and four-cell stages (not statistically significant). Compared with the one in POZI group, the ratio of antiapoptotic Bcl-xl gene to proapoptotic Bax gene, an indicator of the ability to resist apoptosis, was lower in POZD group at the one-cell stage, but higher at the two- and four-cell stages. Expression levels of Oct4 and Nanog associated with pluripotency were lower in POZD group than the ones in POZI group at the morula stage (not statistically significant). Noteworthily, the expression of Nanog was significantly lower in POZD group versus POZI group (P < 0.05), whereas relative expression of Oct4 was significantly higher in the former at the blastocyst stage (P < 0.01). In conclusion, PCV2, which attached to ZP, was able to enter mature porcine oocytes with damaged ZP and subsequently reduced the developmental competence and quality of the oocytes after parthenogenetic activation. PMID:25062959

Zhao, Haijing; Ji, Qianqian; Zhao, Guangyin; Song, Zhenwei; Du, Baozhu; Nie, Yu; Chen, Yaosheng; Cong, Peiqing

2014-10-01

128

Use of Both Cumulus Cells’ Transcriptomic Markers and Zona Pellucida Birefringence to Select Developmentally Competent Oocytes in Human Assisted Reproductive Technologies  

PubMed Central

Background Selection of the best oocyte for subsequent steps of fertilization and embryo transfer was shown to be the crucial step in human infertility treatment procedure. Oocyte selection using morphological criteria mainly Zona pellucida (ZP) has been the gold standard method in assisted reproductive technologies (ART) clinics, but this selection approach has limitations in terms of accuracy, objectivity and constancy. Recent studies using OMICs-based approaches have allowed the identification of key molecular markers that quantitatively and non-invasively predict the oocyte quality for higher pregnancy rates and efficient infertility treatment. These biomarkers are a valuable reinforcement of the morphological selection criteria widely used in in vitro fertilization (IVF) clinics. In this context, this study was designed to investigate the relationship between transcriptomic predictors of oocyte quality found by our group and the conventional morphological parameters of oocyte quality mainly the ZP birefringence. Results Microarray data revealed that 48 and 27 differentially expressed candidate genes in cumulus cells (CCs) were respectively overexpressed and underexpressed in the ZGP (Zona Good Pregnant) versus ZBNP (Zona Bad Non Pregnant) groups. More than 70% of previously reported transcriptomic biomarkers of oocyte developmental competence were confirmed in this study. The analysis of possible association between ZP birefringence versus molecular markers approach showed an absence of correlation between them using the current set of markers. Conclusions This study suggested a new integrative approach that matches morphological and molecular approaches used to select developmentally competent oocytes able to lead to successful pregnancy and the delivery of healthy baby. For each ZP birefringence score, oocytes displayed a particular CCs' gene expression pattern. However, no correlations were found between the 7 gene biomarkers of oocyte developmental potential and the ZP birefringence score. Further studies using larger lists of candidate markers are required to identify suitable genes that are highly correlated with the morphological criteria, and therefore able to reinforce the accuracy of oocyte selection and the effectiveness of infertility treatment.

2015-01-01

129

Estudio del CH interestelar  

NASA Astrophysics Data System (ADS)

El objetivo principal de este proyecto consiste en el estudio de la distribución y abundancia del CH en nubes interestelares a través de la observación de las líneas hiperfinas del CH en 3,3 GHz. El CH es una molécula de amplia distribución en el espacio interestelar y una de las pocas especies que han sido observadas tanto con técnicas de radio como ópticas. Desde el punto de vista tecnológico se ha desarrollado un cabezal de receptor que permitirá la realización de observaciones polarimétricas en la frecuencia de 3,3 GHz, con una temperatura del sistema de 60 K y un ancho de banda de 140 MHz, y que será instalado en el foco primario de la antena parabólica del IAR. El cabezal del receptor es capaz de detectar señales polarizadas, separando las componentes de polarización circular derecha e izquierda. Para tal fin el cabezal consta de dos ramas receptoras que amplificarán la señal y la trasladarán a una frecuencia más baja (frecuencia intermedia), permitiendo de esa forma un mejor transporte de la señal a la sala de control para su posterior procesamiento. El receptor además de tener características polarimétricas, podrá ser usado en el continuo y en la línea, utilizando las ventajas observacionales y de procesamiento de señal que actualmente posee el IAR.

Olano, C.; Lemarchand, G.; Sanz, A. J.; Bava, J. A.

130

Instantánea del cáncer de esófago  

Cancer.gov

Información sobre las tendencias de incidencia, mortalidad y financiamiento del NCI sobre el cáncer de esófago; así como ejemplos de actividades del NCI y adelantos en la investigación de este tipo de cáncer.

131

Instantánea del cáncer de próstata  

Cancer.gov

Información sobre las tendencias de incidencia, mortalidad y financiamiento del NCI sobre el cáncer de próstata; así como ejemplos de actividades del NCI y adelantos en la investigación de este tipo de cáncer.

132

Instantánea del cáncer de vejiga  

Cancer.gov

Información sobre las tendencias de incidencia, mortalidad y financiamiento del NCI sobre el cáncer de vejiga; así como ejemplos de actividades del NCI y adelantos en la investigación de este tipo de cáncer.

133

Instantánea del sarcoma de Kaposi  

Cancer.gov

Información sobre las tendencias de incidencia, mortalidad y financiamiento del NCI sobre el sarcoma de Kaposi; así como ejemplos de actividades del NCI y adelantos en la investigación de este tipo de cáncer.

134

Instantánea del cáncer de pulmón  

Cancer.gov

Información sobre las tendencias de incidencia, mortalidad y financiamiento del NCI sobre el cáncer de pulmón; así como ejemplos de actividades del NCI y adelantos en la investigación de este tipo de cáncer.

135

Instantánea del cáncer de endometrio  

Cancer.gov

Información sobre las tendencias de incidencia, mortalidad y financiamiento del NCI sobre el cáncer de endometrio; así como ejemplos de actividades del NCI y adelantos en la investigación de este tipo de cáncer.

136

Instantánea del cáncer de páncreas  

Cancer.gov

Información sobre las tendencias de incidencia, mortalidad y financiamiento del NCI sobre el cáncer de páncreas; así como ejemplos de actividades del NCI y adelantos en la investigación de este tipo de cáncer.

137

Determinacion de periodos fundamentales del suelo mediante vibraciones ambientales en el municipio de Humacao, Puerto Rico  

NASA Astrophysics Data System (ADS)

La tecnica de Nakamura ha sido utilizada a nivel mundial para determinar periodos fundamentales del suelo. La tecnica consiste en calcular y graficar cocientes espectrales H/V de vibraciones ambientales registradas sobre el suelo. Mediciones de vibraciones ambientales fueron tomadas en 151 lugares dentro del municipio de Humacao, localizado al este de Puerto Rico. Los datos se procesaron utilizando espectros de Fourier y espectros de potencia. La tecnica fue validada al compararla con los resultados de cocientes espectrales H/V de registros de sismos debiles y tambien con una modelacion numerica realizada con datos de un ensayo "downhole". Las graficas de los cocientes espectrales H/V fueron divididas en casos y grupos, los cuales dependen de la facilidad para identificar el periodo fundamental pico y amplitudes en frecuencias menores de 1 Hz, respectivamente. Los resultados obtenidos con ambos espectros fueron comparados y se concluye que los mismos se complementan para proveer resultados mas confiables. Se crearon mapas de periodos fundamentales, factores de amplitud, isoperiodos y clasificacion sismica de sitio. Los mapas de isoperiodos fueron realizados en las zonas mas pobladas sobre depositos de suelo. El mapa de periodos fundamentales del suelo mostro buena correlacion con la geologia local. El mapa de clasificacion sismica derivado de periodos de sitio fue comparado con el mapa de clasificacion sismica derivado de barrenos geotecnicos. El mapa de clasificacion obtenido de periodos puede sobreestimar un poco algunas clasificaciones del suelo. Sin embargo, este mapa puede proveer un estimado aproximado de la velocidad de onda de corte promedio del suelo hasta una profundidad de 100 pies (30 metros).

Cintron Aponte, Rommel

138

Fisiología del crecimiento  

Microsoft Academic Search

ExtractoEl crecimiento humano es un proceso dinámico y complejo que comienza con la fertilización del óvulo y se completa con la fusión de las epífisis y las metáfisis de los huesos largos, que caracteriza la terminación de la adolescencia. El crecimiento ocurre en fases, con características distintivas en términos de influencias dominantes derivadas de factores y patrones genéticos, ambientales\\/nutricionales y

Arlan L. Rosenbloom

2007-01-01

139

La crisis del neoliberalismo  

Microsoft Academic Search

En este artículo se analiza la actual crisis en relación al modelo de gestión neoliberal de las economías capitalistas durante los treinta últimos años. En primer lugar se caracterizan los rasgos básicos de la regulación neoliberal. En segundo lugar se analiza la crisis actual en relación a estos rasgos, en concreto se considera el papel del sector financiero, el funcionamiento

Albert Recio Andreu

2009-01-01

140

-DERECHO PBLICO DEL ESTADO AUTONMICO La implantacin del Mster universitario en Derecho Pblico del Estado Autonmico  

E-print Network

- DERECHO P�BLICO DEL ESTADO AUTON�MICO La implantación del Máster universitario en Derecho Público del Estado Autonómico extinguirá el Máster Oficial en Derecho Autonómico y Local. Por esta razón se materias del Máster Oficial en Derecho Autonómico y Local. Los estudiantes que comenzaron el Máster Oficial

Rey Juan Carlos, Universidad

141

The Del Rio ataxite, Texas  

NASA Technical Reports Server (NTRS)

Basic data are presented on the Del Rio, Nordheim, and Monahans ataxites found in Texas. Results are reported for bulk-chemistry analysis, metallographic observations, and electron-microprobe analysis of the Del Rio meteorite. It is shown that Del Rio is distinctly different from the other two ataxites in terms of nickel, phosphorous, and carbon content, and is composed of at least three coarse grains in different crystallographic orientations. All the kamacite in Del Rio is found to have transformation structures that are probable shock products, and minor inclusions of daubreelite, schreibersite, and troilite are observed. It is concluded that Del Rio was apparently mildly shocked prior to its fall.

Henderson, E. P.; King, E. A.

1977-01-01

142

Seroprevalence and risk factors of toxoplasmosis in cattle from extensive and semi-intensive rearing systems at Zona da Mata, Minas Gerais state, Southern Brazil  

PubMed Central

Background Concerning the infection of humans by T. gondii, limited efforts have been directed to the elucidation of the role of horizontal transmission between hosts. One of the main routes of transmission from animals to humans occurs through the ingestion of raw or insufficiently cooked meat. However, even though the detection of T. gondii in meat constitutes an important short-term measure, control strategies can only be accomplished by a deeper understanding of the epidemiology of toxoplasmosis. The present study aimed to investigate the seroprevalence of toxoplasmosis in cattle from Zona da Mata, Minas Gerais, Brazil, and to identify associated risk factors, through an epidemiological investigation. Methods The animals studied (Bos indicus, breed Nelore or Gir) were reared in the Zona da Mata micro-region and killed at a commercial slaughterhouse at Juiz de Fora, Minas Gerais state. The animals came from 53 cattle farms with extensive (predominantly pasture feeding management) or semi-intensive (food management based on grazing, salt mineral and feed supplementation) rearing systems. Blood samples were collected from 1200 animals, and assigned to Indirect Fluorescent Antibody Test. Results When analyzing IgG anti-T.gondii we found an overall seroprevalence of 2.68%. In Brazil prevalences vary from 1.03% to 60%. Although in the present study, the seroprevalence per animal is considered low compared to those observed in other studies, we found out that of the 53 farms analyzed, 17 (34.69%) had one or more positive cattle. It is a considerable percentage, suggesting that the infection is well distributed through the Zona da Mata region. The results of the epidemiological investigation showed that the main risk factors of Toxoplasma gondii infection are related to animal management and to the definive host. There was a relationship between the number of seropositive cattle and the presence and number of resident cats, presence and number of stray cats, presence of cats walking freely, rat control by using cats and feed storage. Conclusion These results may contribute to the development of preventive strategies in Brazil and other developing countries were extensive and semi-intensive cattle rearing systems are very widespread and the efforts to control this important zoonotic disease have attained little success. PMID:23800302

2013-01-01

143

Nevado del Huila, Columbia  

NASA Technical Reports Server (NTRS)

Nevado del Huila Volcano in Colombia is actually a volcanic chain running north to south, capped by a glacier. With peaks ranging in height from 2,600 to 5,780 meters (8,530 to 18,960 feet), Nevado del Huila is a stratovolcano composed of alternating layers of hardened lava, solidified ash, and volcanic rocks. Its first recorded eruption occurred in the mid-sixteenth century. The long-dormant volcano erupted again in mid-April 2007. A few months before the eruption, the Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER) on NASA's Terra satellite captured this image of Nevado del Huila, on February 23, 2007. In this image, the bright white area just east of the central summit is ice. Immediately west of the summit are bare rocks, appearing as blue-gray. West of those rocks, white reappears, but this patch of white results from clouds hovering in the nearby valley. In the east, the colors turn to brown (indicating bare rock) and bright green (indicating vegetation). ASTER photographed Nevado del Huila near the end of a long phase of quietude. On April 17, 2007, local authorities recorded seismic activity associated with rock fracturing on the volcano's central summit, according to the ReliefWeb Website. Activity intensified the following day with an eruption and mudflows, forcing thousands of nearby residents to evacuate. As the Associated Press reported, the eruption caused avalanches and floods that wiped away both houses and bridges. It marked the volcano's first recorded eruption since the Spanish colonized the area five centuries earlier. NASA image created by Jesse Allen, using data provided courtesy of the NASA/GSFC/MITI/ERSDAC/JAROS, and U.S./Japan ASTER Science Team.

2007-01-01

144

Identification of a Novel TGF-?-Binding Site in the Zona Pellucida C-terminal (ZP-C) Domain of TGF-?-Receptor-3 (TGFR-3)  

PubMed Central

The zona pellucida (ZP) domain is present in extracellular proteins such as the zona pellucida proteins and tectorins and participates in the formation of polymeric protein networks. However, the ZP domain also occurs in the cytokine signaling co-receptor transforming growth factor ? (TGF-?) receptor type 3 (TGFR-3, also known as betaglycan) where it contributes to cytokine ligand recognition. Currently it is unclear how the ZP domain architecture enables this dual functionality. Here, we identify a novel major TGF-?-binding site in the FG loop of the C-terminal subdomain of the murine TGFR-3 ZP domain (ZP-C) using protein crystallography, limited proteolysis experiments, surface plasmon resonance measurements and synthetic peptides. In the murine 2.7 Å crystal structure that we are presenting here, the FG-loop is disordered, however, well-ordered in a recently reported homologous rat ZP-C structure. Surprisingly, the adjacent external hydrophobic patch (EHP) segment is registered differently in the rat and murine structures suggesting that this segment only loosely associates with the remaining ZP-C fold. Such a flexible and temporarily-modulated association of the EHP segment with the ZP domain has been proposed to control the polymerization of ZP domain-containing proteins. Our findings suggest that this flexibility also extends to the ZP domain of TGFR-3 and might facilitate co-receptor ligand interaction and presentation via the adjacent FG-loop. This hints that a similar C-terminal region of the ZP domain architecture possibly regulates both the polymerization of extracellular matrix proteins and cytokine ligand recognition of TGFR-3. PMID:23826237

Diestel, Uschi; Resch, Marcus; Meinhardt, Kathrin; Weiler, Sigrid; Hellmann, Tina V.; Mueller, Thomas D.; Nickel, Joachim; Eichler, Jutta; Muller, Yves A.

2013-01-01

145

Diseño y optimización del procesamiento térmico de alimentos envasados.  

E-print Network

??Contiene: Introducción; Objetivos; Diseño del procesamiento térmico: antecedentes; Diseño del procesamiento térmico: materiales y métodos; Diseño del procesamiento térmico: resultados y discusión; Optimización del procesamiento… (more)

Ansorena, María Roberta

2009-01-01

146

Acerca del Centro para la Salud Mundial del NCI  

Cancer.gov

El Centro para la Salud Mundial (CGH) coordina y fija las prioridades en las actividades que lleva a cabo el Instituto Nacional del Cáncer a nivel mundial. Su objetivo es avanzar la investigación mundial del cáncer y reducir las muertes causadas por esta enfermedad.

147

EL ORIGEN BIOLÓGICO DEL DERECHO  

Microsoft Academic Search

En este trabajo se aborda el posible origen evolutivo del derecho como una consecuencia del desarrollo social de nuestra especie. Otras especies con sistemas sociales similares presentan varias reglas para la convivencia en grupo. Algunas de estas reglas son comunes en todas las especies con comportamiento social. El desarrollo de la sociobiología en las últimas décadas es una herramienta importante

Axel P. Retana-Salazar

148

Proteomic characterization and evolutionary analyses of zona pellucida domain-containing proteins in the egg coat of the cephalochordate, Branchiostoma belcheri  

PubMed Central

Background Zona pellucida domain-containing proteins (ZP proteins) have been identified as the principle constituents of the egg coat (EC) of diverse metazoan taxa, including jawed vertebrates, urochordates and molluscs that span hundreds of millions of years of evolutionary divergence. Although ZP proteins generally contain the zona pellucida (ZP) structural modules to fulfill sperm recognition and EC polymerization functions during fertilization, the primary sequences of the ZP proteins from the above-mentioned animal classes are drastically different, which makes it difficult to assess the evolutionary relationships of ZP proteins. To understand the origin of vertebrate ZP proteins, we characterized the egg coat components of Branchiostoma belcheri, an invertebrate species that belongs to the chordate subphylum Cephalochordata. Results Five ZP proteins (BbZP1-5) were identified by mass spectrometry analyses using the egg coat extracts from both unfertilized and fertilized eggs. In addition to the C-terminal ZP module in each of the BbZPs, the majority contain a low-density lipoprotein receptor domain and a von Willebrand factor type A (vWFA) domain, but none possess an EGF-like domain that is frequently observed in the ZP proteins of urochordates. Fluorescence in situ hybridization and immuno-histochemical analyses of B. belcheri ovaries showed that the five BbZPs are synthesized predominantly in developing eggs and deposited around the extracellular space of the egg, which indicates that they are bona fide egg coat ZP proteins. BbZP1, BbZP3 and BbZP4 are significantly more abundant than BbZP2 and BbZP5 in terms of gene expression levels and the amount of mature proteins present on the egg coats. The major ZP proteins showed high polymorphism because multiple variants are present with different molecular weights. Sequence comparison and phylogenetic analysis between the ZP proteins from cephalochordates, urochordates and vertebrates showed that BbZP1-5 form a monophyletic group and share no significant sequence similarities with the ZP proteins of urochordates and the ZP3 subtype of jawed vertebrates. By contrast, small regions of homology were identifiable between the BbZP and ZP proteins of the non-jawed vertebrate, the sea lamprey Petromyzon marinus. The lamprey ZP proteins were highly similar to the ZP1 and ZP2 subtypes of the jawed vertebrates, which suggests that the ZP proteins of basal chordates most likely shared a recent common ancestor with vertebrate ZP1/2 subtypes and lamprey ZP proteins. Conclusions The results document the spectra of zona pellucida domain-containing proteins of the egg coat of basal chordates. Particularly, the study provides solid evidence for an invertebrate origin of vertebrate ZP proteins and indicates that there are diverse domain architectures in ZP proteins of various metazoan groups. PMID:23216630

2012-01-01

149

Adrenomedullin and its receptors are expressed in the zona glomerulosa of human adrenal gland: evidence that ADM enhances proliferation and decreases apoptosis in cultured ZG cells.  

PubMed

Adrenomedullin (ADM) is a hypotensive peptide, that derives from the proteolytic cleavage of pro(p)ADM and acts through two subtypes of receptors, called L1-receptor (L1-R) and calcitonin receptor-like receptor (CRLR). CRLR may function as a calcitonin gene-related peptide or a selective ADM receptor depending on the expression of the subtype 1 or the subtypes 2 and 3 of a family of proteins, named receptor-activity-modifying protein (RAMPs). Reverse transcription (RT)-polymerase chain reaction (PCR) consistently allowed the detection of pADM mRNA in zona glomerulosa (ZG), but not zona fasciculata-reticularis (ZF/R) cells of eight human adrenal cortexes. Despite the rather high level of pADM mRNA, immunocytochemistry and radioimmunoassay showed that the expression of ADM as protein in the ZG was weak. However, ZG cells expressed peptidyl-glycine alpha-amidating monooxigenase, the enzyme converting immature ADM to the mature peptide, thereby suggesting their potential ability to produce active ADM. RT-PCR demonstrated the presence in ZG, but not ZF/R cells of the specific mRNAs of L1-R, CRLR and RAMPs1-3. Semiquantitative PCR showed that L1-R expression was higher than that of CRLR, while the level of expression of the three RAMPs was nearly the same. ADM (10(-8) M) inhibited both angiotensin-II (10(-9) M)- and K(+) (10(-2) M)-stimulated aldosterone secretion from cultured ZG cells, without affecting basal production. ADM (10(-8) M) also increased proliferative activity and lowered apoptotic deletion of cultured cells. All the effect of ADM were reversed by the ADM-receptor antagonist ADM(22-52). In conclusion our study provides evidence that i) human ZG cells express ADM and ADM receptors of both L1 and CRLR/PAMP2,3 subtypes; and ii) through the activation of these receptors, ADM exerts an aldosterone antisecretagogue action and a growth promoting effect on cultured ZG cells, the latter an effect which includes both stimulation of proliferation and inhibition of apoptosis. Taken together, these findings make it likely that endogenous ADM system plays a potentially important role in the paracrine/ autocrine regulation of human adrenal cortex. PMID:11786920

Rebuffat, Piera; Forneris, Myriam L; Aragona, Francesco; Ziolkowska, Agnieszka; Malendowicz, Ludwik K; Nussdorfer, Gastone G

2002-02-01

150

Yeast DEL assay detects clastogens.  

PubMed

Chromosomal rearrangements, including DNA deletions are involved in carcinogenesis. The deletion (DEL) assay scoring for DNA deletions in the yeast Saccharomyces cerevisiae is able to detect a wide range of carcinogens. Among approximately 60 compounds of known carcinogenic activity, the DEL assay detected 86% correctly whereas the Ames Salmonella assay detected only 30% correctly [R.J. Brennan, R.H. Schiestl, Detecting carcinogens with the yeast DEL assay, Methods Mol. Biol. 262 (2004) 111-124]. Since the DEL assay is highly inducible by DNA double strand breaks, this study examined the utility of the DEL assay for detecting clastogens. Ten model compounds, with varied mechanisms of genotoxicity, were examined for their effect on the frequency of DNA deletions with the DEL assay. The compounds tested were: actinomycin D, camptothecin, methotrexate and 5-fluorodeoxyuridine, which are anticancer agents, noscapine and furosemide are therapeutics, acridine, methyl acrylate and resorcinol are industrial chemicals and diazinon is an insecticide. The in vitro micronucleus assay (IVMN) in CHO cells, a commonly used tool for detection of clastogens, was performed on the same compounds and the results of the two assays were compared. The results of our study show that there is 70% concordance in the presence of metabolic activation (rat liver S9) and 80% concordance in the absence of metabolic activation between the DEL assay and the standard in vitro micronucleus assay. The lack of cytotoxicity observed for four of the ten compounds examined indicates limited diffusion of lipophilic compounds across the yeast cell wall. Thus, the development of a more permeable yeast tester strain is expected to greatly improve concordance of the DEL assay with the IVMN assay. The yeast DEL assay is inexpensive, amenable to automation and requires less expertise to perform than the IVMN. Thus, it has a strong potential as a robust, fast and economical screen for detecting clastogens in vitro. PMID:15781217

Kirpnick, Zhanna; Homiski, Michael; Rubitski, Elizabeth; Repnevskaya, Marina; Howlett, Niall; Aubrecht, Jiri; Schiestl, Robert H

2005-04-01

151

Adrenomedullin and its receptors are expressed in the zona glomerulosa of immature and adult rat adrenals: evidences of upregulation of ADM system in immature glands.  

PubMed

Evidence has been provided that adrenomedullin (ADM) stimulates the proliferative activity of adult rat adrenal zona glomerulosa (ZG). However, the selective ADM receptor antagonist ADM(22-52), although being able to block ADM effect, was per se ineffective. In contrast, in the companion paper, we showed that ADM(22-52) depresses the proliferation rate of ZG in 20-day-old rats, suggesting the involvement of endogenous ADM system in adrenal maturation. Hence, we investigated by semiquantitative reverse transcription-polymerase chain reaction and radioimmune assay the expression of ADM system in adult and immature rat ZG. ProADM mRNA and ADM-immunoreactivity were both more elevated in immature- than adult-rat ZG. Plasma ADM concentration did not show significant age-related differences. ADM acts via two subtypes of ADM(22-52)-sensitive receptors: the L1 receptor (L1-R) and the calcitonin-receptor-like-receptor (CRLR), the latter behaves as selective ADM receptor only in the presence of the receptor-activity-modifying proteins (RAMPs)2 and 3. L1-R expression was enhanced in immature rat ZG, while CRLR and RAMP(2,3) expression did not display significant differences. It is concluded that the endogenous ADM system located in the ZG is upregulated in immature rats, and plays an important autocrine-paracrine role in the maintenance of the elevated growth rate during adrenal maturation. PMID:12060856

Rebuffat, Piera; Forneris, Myriam L; Macchi, Carlo; Malendowicz, Ludwik K; Trejter, Marcin; Nussdorfer, Gastone G

2002-07-01

152

Tuberoinfundibular Peptide of 39 Residues-Immunoreactive Fibers in the Zona Incerta and the Supraoptic Decussations Terminate in the Neuroendocrine Hypothalamus  

PubMed Central

Tuberoinfundibular peptide of 39 residues (TIP39) is expressed by neurons in the subparafascicular area, the posterior intralaminar complex of the thalamus and the pontine medial paralemniscal nucleus. TIP39-positive fibers from these areas do not form individual bundles or fascicles, they join other pathways to reach their innervated brain areas. Fibers arise from TIP39 perikarya located in the subparafascicular area and the posterior intralaminar complex of the thalamus could be followed to the hypothalamus. After uni- and bilateral posterolateral surgical deafferentations of the hypothalamus, accumulation of TIP39 immunoreactivity was observed in the fibers caudal to the knife cut, while it disappeared completely rostral to the transection. In serial sections of the forebrain, we could follow TIP39-ir fibers coursing within the zona incerta and the supraoptic decussations. TIP39-positive fibers that join the incerto-hypothalamic pathway reach the medio-dorsal part of the hypothalamus and form moderate to high density networks in the dorsomedial and paraventricular nuclei. The other set of TIP39-positive axons from the subthalamic area join the fibers of the supraoptic decussations and run in an antero-medial direction through the most ventral portion of the hypothalamus up to the retrochiasmatic area, where they crossover. A certain portion of these TIP39-positive fibers terminates in the territories of the arcuate and the medial preoptic nuclei, as well as in the retrochiasmatic area. PMID:20972828

Usdin, T. B.; Makara, G. B.; Dobolyi, A.

2012-01-01

153

Roles of the zona pellucida and functional exposure of the sperm-egg fusion factor 'IZUMO' during in vitro fertilization in pigs.  

PubMed

The zona pellucida (ZP) is considered to play important roles in the prevention of polyspermy in mammalian oocytes. However, in pigs we have shown that the presence of the ZP accelerates sperm penetration into the ooplasm during in vitro fertilization (IVF). In the present study, we investigated the effects of the ZP on sperm binding, acrosomal status, and functional exposure of IZUMO, a critical factor involved in sperm-egg fusion, during IVF in pigs. We evaluated the numbers and acrosomal statuses of sperm binding to the ZP and oolemma, and being present in the ZP and perivitelline space (PVS) using ZP-intact and ZP-free oocytes. More sperm bound to the ZP than to the oolemma. The average number of sperm present in the PVS was 0.44-0.51 per oocyte, and all sperm had lost their acrosomes. The proportion of sperm that were immunopositive for anti-IZUMO antibody was significantly higher after they were passing or had passed through the ZP. Furthermore, addition of anti-IZUMO antibody to the fertilization medium significantly inhibited the penetration of sperm into ZP-free oocytes. These results suggest that, in pigs, the ZP induces the acrosome reaction, which is associated with the functional exposure of IZUMO, resulting in completion of fertilization. PMID:24450993

Tanihara, Fuminori; Nakai, Michiko; Men, Nguyen Thi; Kato, Noriko; Kaneko, Hiroyuki; Noguchi, Junko; Otoi, Takeshige; Kikuchi, Kazuhiro

2014-04-01

154

Olfactory receptor signaling is regulated by the post-synaptic density 95, Drosophila discs large, zona-occludens 1 (PDZ) scaffold multi-PDZ domain protein 1.  

PubMed

The unique ability of mammals to detect and discriminate between thousands of different odorant molecules is governed by the diverse array of olfactory receptors expressed by olfactory sensory neurons in the nasal epithelium. Olfactory receptors consist of seven transmembrane domain G protein-coupled receptors and comprise the largest gene superfamily in the mammalian genome. We found that approximately 30% of olfactory receptors possess a classical post-synaptic density 95, Drosophila discs large, zona-occludens 1 (PDZ) domain binding motif in their C-termini. PDZ domains have been established as sites for protein-protein interaction and play a central role in organizing diverse cell signaling assemblies. In the present study, we show that multi-PDZ domain protein 1 (MUPP1) is expressed in the apical compartment of olfactory sensory neurons. Furthermore, on heterologous co-expression with olfactory sensory neurons, MUPP1 was shown to translocate to the plasma membrane. We found direct interaction of PDZ domains 1 + 2 of MUPP1 with the C-terminus of olfactory receptors in vitro. Moreover, the odorant-elicited calcium response of OR2AG1 showed a prolonged decay in MUPP1 small interfering RNA-treated cells. We have therefore elucidated the first building blocks of the putative 'olfactosome', brought together by the scaffolding protein MUPP1, a possible central nucleator of the olfactory response. PMID:19909339

Dooley, Ruth; Baumgart, Sabrina; Rasche, Sebastian; Hatt, Hanns; Neuhaus, Eva M

2009-12-01

155

The Postsynaptic Density 95/Disc-Large/Zona Occludens Protein Syntenin Directly Interacts with Frizzled 7 and Supports Noncanonical Wnt Signaling  

PubMed Central

Wnt signaling pathways are essential for embryonic patterning, and they are disturbed in a wide spectrum of diseases, including cancer. An unresolved question is how the different Wnt pathways are supported and regulated. We previously established that the postsynaptic density 95/disc-large/zona occludens (PDZ) protein syntenin binds to syndecans, Wnt coreceptors, and known stimulators of protein kinase C (PKC)? and CDC42 activity. Here, we show that syntenin also interacts with the C-terminal PDZ binding motif of several Frizzled Wnt receptors, without compromising the recruitment of Dishevelled, a key downstream Wnt-signaling component. Syntenin is coexpressed with cognate Frizzled during early development in Xenopus. Overexpression and down-regulation of syntenin disrupt convergent extension movements, supporting a role for syntenin in noncanonical Wnt signaling. Syntenin stimulates c-jun phosphorylation and modulates Frizzled 7 signaling, in particular the PKC?/CDC42 noncanonical Wnt signaling cascade. The syntenin–Frizzled 7 binding mode indicates syntenin can accommodate Frizzled 7–syndecan complexes. We propose that syntenin is a novel component of the Wnt signal transduction cascade and that it might function as a direct intracellular link between Frizzled and syndecans. PMID:18256285

Luyten, Annouck; Mortier, Eva; Van Campenhout, Claude; Taelman, Vincent; Degeest, Gisèle; Wuytens, Gunther; Lambaerts, Kathleen; David, Guido; Bellefroid, Eric J.

2008-01-01

156

Se da a conocer el plan del Instituto Nacional del Cáncer para acelerar la investigación del cáncer  

Cancer.gov

En la 100va Reunión Anual de la Asociación Estadounidense de Investigación del Cáncer realizada en Denver, el director del Instituto Nacional del Cáncer, doctor John E. Niederhuber, dio a conocer detalles importantes, tales como financiamiento de más subvenciones, creación de una plataforma para atención personalizada del cáncer y un programa acelerado de genética del cáncer que hará avanzar la investigación oncológica en este nuevo ambiente económico.

157

Harold Varmus investido bajo juramento como 14.º director del Instituto Nacional del Cáncer  

Cancer.gov

Ganador del Premio Nobel, doctor Harold E. Varmus, prestó juramento hoy como 14.º director del Instituto Nacional del Cáncer (NCI).  "Es muy estimulante que estés de regreso con nosotros", dijo la secretaria del Departamento de Salud y Servicios Humanos Kathleen Sebelius en la ceremonia de toma de juramento. “Hoy se abre un nuevo capítulo para el Instituto Nacional del Cáncer”.

158

Impactos del Huracn Isaac en la calidad del agua en Luisiana con MODIS 250m  

E-print Network

lluvias. Por tal razón se quiere estudiar la calidad del agua en el delta del río Mississippi antes1 Impactos del Huracán Isaac en la calidad del agua en Luisiana con MODIS 250m Thais J. Alicea imágenes en ENVI. Palabras clave: Calidad del agua, ENVI, Isaac, Luisiana, MODIS

Gilbes, Fernando

159

Investigations on the possible involvement of the dopaminergic system in the modulation of the growth and steroidogenic capacity of the rat adrenal zona glomerulosa: A coupled morphometric and biochemical study  

Microsoft Academic Search

Summary The effects of metoclopramide (MTC) and bromocriptine (BRC) (two drugs which act as antagonist and agonist of DOPA-receptors, respectively) on the zona glomerulosa of dexamethasone\\/ACTH-treated rats were investigated by coupled biochemical and morphometric techniques. Shortterm (1-h) MTC administration significantly increased the plasma concentration of aldosterone, while long-term (7-day) MTC administration, as well as short- and long-term treatment with BRC

G. Mazzocchi; P. Rebuffat; C. Robba; A. S. Belloni; A. Stachowiak; G. Gottardo; V. Meneghelli; G. G. Nussdorfer

1987-01-01

160

VERBALE DEL CONSIGLIO DEL CORSO DI STUDIO INFORMATICA E TECNOLOGIE PER LA PRODUZIONE DEL del 14 Maggio 2008  

E-print Network

relative agli anni precedenti 4. Manifesti degli Studi 5. Elezione Presidenti Corsi di Studio: adempimenti ingiustificati. PROFESSORI ORDINARI, STRAORDINARI ED ASSOCIATI 1. V. ALBINO SOFTWARE del 21 Febbraio 2008 3. P. BUONO....................... .................. 4. V. CAPRIATI

Malerba, Donato

161

Historia del IAC PRIMERAS EXPEDICIONES  

E-print Network

Astrofísica de Canarias - el Observatorio del Teide, en Tenerife,y el Observatorio del Roque de los Muchachos a esta conclusión después de observar a diversos niveles en Tenerife, desde el mar hasta la montaña de Tenerife que propuso la creación de un observatorio internacional en la Montaña de Guajara. #12;ECLIPSE DE

162

Molecular adjuvant interleukin-33 enhances the antifertility effect of Lagurus lagurus zona pellucida 3 DNA vaccine administered by the mucosal route  

PubMed Central

It has been shown that cytokines can act as molecular adjuvant to enhance the immune response induced by DNA vaccines, but it is unknown whether interleukin 33 (IL-33) can enhance the immunocontraceptive effect induced by DNA vaccines. In the present study, we explored the effects of murine IL-33 on infertility induced by Lagurus lagurus zona pellucida 3 (Lzp3) contraceptive DNA vaccine administered by the mucosal route. Plasmid pcD-Lzp3 and plasmid pcD-mIL-33 were encapsulated with chitosan to generate the nanoparticle chi-(pcD-Lzp3+pcD-mIL-33) as the DNA vaccine. Sixty female ICR mice, divided into 5 groups (n=12/group), were intranasally immunized on days 0, 14, 28, and 42. After intranasal immunization, the anti-LZP3-specific IgG in serum and IgA in vaginal secretions and feces were determined by ELISA. The results showed that chi-(pcD-Lzp3+pcD-mIL-33) co-immunization induced the highest levels of serum IgG, secreted mucosal IgA, and T cell proliferation. Importantly, mice co-immunized with chi-(pcD-Lzp3+pcD-mIL-33) had the lowest birth rate and mean litter size, which correlated with high levels of antibodies. Ovaries from infertile female mice co-immunized with chi-(pcD-Lzp3+pcD-mIL-33) showed abnormal development of ovarian follicles, indicated by atretic follicles and loss of oocytes. Our results demonstrated that intranasal delivery of the molecular adjuvant mIL-33 with chi-pcD-Lzp3 significantly increased infertility by enhancing both systemic and mucosal immune responses. Therefore, chi-(pcD-Lzp3+pcD-mIL-33) co-immunization could be a strategy for controlling the population of wild animal pests. PMID:24345916

Tu, Y.X.; Li, X.P.; Kadir, Z.; Zhang, F.C.

2013-01-01

163

Control of phonatory onset and offset in Parkinson patients following deep brain stimulation of the subthalamic nucleus and caudal zona incerta.  

PubMed

Laryngeal hypokinesia is a common symptom in Parkinson's disease (PD) that affects quality of life. Deep brain stimulation (DBS) is well recognized as a complementary method for treatment of motor symptoms in PD but the outcomes on patients' control over phonatory alternation have yet not been clearly elucidated. The present study examined the effect of subthalamic nucleus STN-DBS (n = 8, aged 51-72 yrs; median = 63 yrs) and caudal Zona incerta cZi-DBS (n = 8, aged 49-71 yrs; median = 61 yrs) on control of onset and offset of phonation in connected speech. The patients were evaluated in a preoperatively (Med ON, 1.5 times the ordinary Levodopa dose) and 12 months post-operatively (Med ON, ordinary Levodopa dose). The results provided evidence of a progressive reduction in the ability to manifest alternations between voicing and voiceless states in a reading task. Mean proportion produced with inappropriate voicing increased from 47.6% to 55.3% and from 62.9% to 68.6% of the total duration for the two groups of patients between Pre-op and Post-op, Stim OFF evaluations. The medial and final parts of the fricative were more affected than the initial part, indicating an increased voicing lead into the following vowel. We propose that this reduction in phonatory control is be due to either progression of the disease, an effect of reduced Levodopa dosage or a microlesional effect. Patients' proficiency in alternating between voiced and voiceless states in connected speech remained unaffected by both STN-DBS and cZi-DBS. PMID:22522070

Karlsson, Fredrik; Blomstedt, Patric; Olofsson, Katarina; Linder, Jan; Nordh, Erik; van Doorn, Jan

2012-08-01

164

Rodent middens, a new method for Quaternary research in arid zones of South America [Paleomadrigueras de roedores, un nuevo me??todo para el estudio del Cuaternario en zonas a??ridas de Sudame??rica  

USGS Publications Warehouse

In arid and semi-arid regions of South America, historical evidence for climate and vegetation change is scarce despite its importance for determining reference conditions and rates of natural variability in areas susceptible to modern desertification. Normal lines of evidence, such as pollen stratigraphies from lakes, are either rare or unobtainable in deserts; studies of late Quaternary vegetation history are few and generally inconclusive. This gap in knowledge may be corrected with discovery and development of fossil rodent middens in rocky environments throughout arid South America. These middens, mostly the work of Lagidium, Phyllotis, Abrocoma and Octodontomys, are rich in readily identifiable plant macrofossils, cuticles and pollen, as well as vertebrate and insect remains. In the North American deserts, more than 2,500 woodrat (Neotoma) middens analyzed since 1960 have yielded a detailed history of environmental change during the past 40,000 years. Preliminary work in the pre-puna, Monte and Patagonian Deserts of western Argentina, the Atacama Desert of northern Chile/southern Peru, the Mediterranean matorral of central Chile, and the Puna of the Andean altiplano suggest a similar potential for rodent middens in South America. Here we borrow from the North American experience to synthesize methodologies and approaches, summarize preliminary work, and explore the potential of rodent midden research in South America.

Betancourt, J.L.; Saavedra, B.

2002-01-01

165

Dieta del pez espada Xiphias gladius Linnaeus, 1758 en distintas zonas de pesca frente a Chile central durante el otoño de 2004 Diet of swordfish Xiphias gladius Linnaeus, 1758 from different fishing zones off central-Chile during autumn 2004  

Microsoft Academic Search

The habitat of the predator and sample size (stomach number) are some of the most important factors to consider in the study of its diet. To investigate these variations we studied the diet of 51 swordfish Xiphias gladius (range: 173-301 cm) in four fishing areas off central Chile (30ºS - 40ºS) during autumn-winter of 2004. Frequency of occurrence, numeric and

Katherine Castillo; Christian M. Ibáñez; Carlos González; Javier Chong

166

Diversidad forrajera del pasto banderita (Bouteloua curtipendula (Michx.) Torr.), en poblaciones de zonas áridas y semiáridas de México Forage diversity of sideoats grama (Bouteloua curtipendula (Michx.) Torr.) populations in arid and semiarid regions of Mexico  

Microsoft Academic Search

The objectives of the present study were to evaluate sideoats grama (Bouteloua curtipendula (Michx.) Torr.) populations, to set an ex situ plot, and to asses morphological diversity. From 2000 to 2003, 577 sideoats grama populations were collected in 13 Mexican States. In 177 established ecotypes, the following plant morphologic attributes were assessed: vigour, regrowth, forage texture, dry matter production potential,

Carlos Raúl Morales Nieto; Adrián Quero Carrillo; Alicia Melgoza Castillo; Martín Martínez Salvador; Pedro Jurado Guerra

2009-01-01

167

Gestin del agua en producciones  

E-print Network

160 cm 220cm PER 240cm Gestión del agua en producciones de secano #12;#12;Sitio Prof. cm pH CE mmoh 31 oct s/napa soja Maíz Girasol Uso del agua - PER ­ sección control- relación con precipitaciones: Escenario lluvia alta -180,0 -160,0 -140,0 -120,0 -100,0 -80,0 -60,0 -40,0 -20,0 0,0 20/07/2012 19

Nacional de San Luis, Universidad

168

SUPUESTOS IMPLÍCITOS EN LA UTILIZACIÓN DEL CAPITAL ASSETS PRICING MODEL – CAPM PARA EL CÁLCULO DEL COSTO DEL CAPITAL PROPIO – EQUITY  

Microsoft Academic Search

El artículo evidencia los supuestos y problemas que implica la utilización del Capital Assets Pricing Model– CAPM en el cálculo del costo del capital propio de las empresas – Equity, haciendo énfasis en la diferencia que existe entre la forma como toman sus decisiones de inversión quienes lo hacen en el mercado de valores y quienes lo hacen en una

Carlos Arturo Gómez Restrepo; Mario García Molina

2011-01-01

169

Zona Land: Wave Interference 3  

NSDL National Science Digital Library

This applet demonstrates basic wave superposition. The user can draw two waveforms and view the resulting wave on a string as they move in opposite directions towards the middle of the string. The user can select to view each of the individual waves, the sum, or both. The simulation can be slowed down to help the user examine the phenomenon more closely.

Zobel, Edward

2008-08-10

170

Instantánea del cáncer de seno (mama)  

Cancer.gov

Información sobre las tendencias de incidencia, mortalidad y financiamiento del NCI sobre el cáncer de seno (mama); así como ejemplos de actividades del NCI y adelantos en la investigación de este tipo de cáncer.

171

Instantánea del cáncer de cuello uterino  

Cancer.gov

Información sobre las tendencias de incidencia, mortalidad y financiamiento del NCI sobre el cáncer de cuello uterino; así como ejemplos de actividades del NCI y adelantos en la investigación de este tipo de cáncer.

172

Rafael Molina Bases del filtro de Kalman 1 Bases del filtro de Kalman  

E-print Network

Rafael Molina Bases del filtro de Kalman 1 Bases del filtro de Kalman Rafael Molina Soriano Depto Ciencias de la Computación e IA Universidad de Granada #12;Rafael Molina Bases del filtro de Kalman 2 Contenidos ! Introducción. ! El filtro de Kalman " Modelo del sistema " Modelo de medida " Formulación de la

Granada, Universidad de

173

Reglament d'organitzaci i funcionament del departament de Teoria del Senyal i Comunicacions  

E-print Network

Reglament d'organització i funcionament del departament de Teoria del Senyal i Comunicacions Acord departament de Teoria del Senyal i Comunicacions · Document proposta informat favorablement per la Comissió de/07/2014 Secretaria general 21 de juliol de 2014 #12;REGLAMENT D'ORGANITZACI� I FUNCIONAMENT DEL DEPARTAMENT DE TEORIA

Yannuzzi Sanchez, Marcelo

174

La evolución de la geografía y del trabajo del geógrafo en Rusia  

Microsoft Academic Search

La geografía rusa se fomentó, desde finales del siglo XIX, como una ciencia práctica en relación directa con el desarrollo económico del país. El trabajo del geógrafo, que evolucionó bajo la influencia de los avatares políticos, económicos y sociales, se centra sobre los estudios naturalistas y utilitaristas del espacio geográfico en el caso de la geografía física –área dominante en

Marina Frolova

2007-01-01

175

SERVICIO DE DEPORTES NORMATIVA DE USO DEL  

E-print Network

SERVICIO DE DEPORTES NORMATIVA DE USO DEL SERVICIO DE FISIOTERAPIA #12;ÍNDICE EXPOSICI�N DE MOTIVOS..................................................................................... 4 #12;NORMATIVA DE USO DEL SERVICIO DE FISIOTERAPIA VICERRECTORADO DE CULTURA, DEPORTES Y POLÍTICA datos del Servicio de Deportes y que formen parte de los siguientes programas: a) Jugadores/as de los

Escolano, Francisco

176

REFLEXIONES ÉTICAS A PARTIR DEL PROYECTO UNASUR  

Microsoft Academic Search

Este artículo pretende identificar los principios éticos del proyecto UNASUR tomando como punto de partida el discurso pronunciado por Luiz Inácio Lula da Silva en mayo del 2008 en Brasilia y entrevistas realizadas por representantes de Prensa Latina. Se analiza este documento por ser Lula uno de los fundadores del proyecto de La Unión de Naciones Suramericanas (UNASUR), demostrando la

Cintia Beatriz Pérez Lanza; Ana Maria Infante Aguilar

2011-01-01

177

EVOLUZIONE-WEB -1 -Evoluzione del Web  

E-print Network

EVOLUZIONE-WEB - 1 - Evoluzione del Web (fonte prof. Polillo) #12;- 2 - L'evoluzione del web EVOLUZIONE-WEB · Dal primo sito Web (1991) il Web è in continua crescita, e in continua evoluzione tecnologia, il mercato, i comportamenti delle persone · Le fasi della storia del Web: Web 1.0, Web 2.0, il

De Antonellis, Valeria

178

Tratamiento actual del estreñimiento infantil  

Microsoft Academic Search

ResumenEl estreñimiento infantil es un problema mundial. Es una de las molestias más comunes que tienen que afrontar tanto los pediatras generales como los gastroenterólogos pediátricos. El tratamiento del estreñimiento crónico es problemático, a menudo exige un seguimiento a largo plazo y el uso de medicamentos. A pesar de su elevada frecuencia, se han realizado pocos ensayos aleatorizados para investigar

Olivia Liem; Carlo Di Lorenzo; Jan A. J. M Taminiau; Hayat M. Mousa; Marc A. Benninga

2007-01-01

179

La Universidad de Alicante organiza una observacin del eclipse de Luna del mircoles  

E-print Network

La Universidad de Alicante organiza una observación del eclipse de Luna del miércoles La Universidad de Alicante ha preparado una observación del eclipse total de Luna que se producirá la noche del astronómica así como su instrumental con el fin de explicar el desarrollo del eclipse. Previo a la observación

Escolano, Francisco

180

EL ESTUDIO DEL PLUMBISMO EN DOANA Y OTROS HUMEDALES ANDALUCES  

E-print Network

azulón Anas platyrhynchos, y se detectaron intoxicaciones letales en ánsar común y ánade rabudo Anas acuta (Mateo et al., #12;6 1998). También se estudió la densidad de plomo en los suelos de las zonas

Figuerola, Jordi

181

Ayuda para usar el sitio web en español del Instituto Nacional del Cáncer  

Cancer.gov

Página de guía que le permite al lector entender la forma en que está organizado el sitio web del Instituto Nacional del Cáncer (NCI), las categorías de información disponibles y las políticas que rigen este sitio web.

182

El astrologo y el Emperador del Ganges1 Nota preliminar  

E-print Network

El astr´ologo y el Emperador del Ganges1 Nota preliminar El explorador y aventurero Sir Richard~nos las Actas de las audiencias del Emperador del Ganges, pero apenas logr´o recopilar algunos de los comunicante: Las audiencias del Emperador del Ganges eran re- gistradas en Actas, con todo lujo de detalles

Fernández Gallardo, Pablo

183

El Corral del Veleta: enclave geográfico singular del Parque Nacional de Sierra Nevada  

Microsoft Academic Search

Resumen: La unidad del Veleta, por sus valores científicos y culturales, es enclave singular del Parque Nacional de Sierra Nevada. En particular, su Corral, que fue reducto glaciar durante la Pequeña Edad del Hielo y que aún alberga hielo fósil y permafrost alpino. Al tratarse de reducto recién deglaciado se desarrollan procesos morfogénicos fríos de especial relevancia. También señalar de

Antonio Gómez Ortiz

184

Estudio bibliométrico de los modelos de medición del concepto de calidad percibida del servicio en Internet  

Microsoft Academic Search

P a l a b r a s c l a v e : marketing de servicios, calidad del servicio al cliente, calidad del servicio en Internet, modelos de evaluación de la calidad del servicio. a b s t r a c t A b i b l i o m e t r i c a n a l

Edison Jair; Duque Oliva; Amparo Cervera Taulet; Carlos Rodríguez Romero

185

Control del dolor: Apoyo para las personas con cáncer  

Cancer.gov

Libro sobre el control del dolor en pacientes con cáncer. Cubre los métodos y medicinas, así como los efectos físicos y emocionales del dolor. Es una adaptación cultural para el público de habla hispana del libro en inglés Pain Control.

186

Le rane delle risaie Osservazioni sugli Iperolidi del  

E-print Network

boettgeri finora è stato segnalato sol- tanto nell'estremo Sudest del Mada- gascar. Si rimanda alle cartine boettgeri) si somigliano molto. Le rane del genere Heterixalus, a seconda della specie e del luogo di

187

CLASSIFICAZIONE MORFOLOGICA QUANTITATIVA DEL TERRITORIO ITALIANO TRAMITE WAVELET  

E-print Network

CLASSIFICAZIONE MORFOLOGICA QUANTITATIVA DEL TERRITORIO ITALIANO TRAMITE WAVELET M. De Agostino una rappresentazione quantitativa della morfologia dell'intero territorio italiano, al fine di del terreno. Il risultato finale della procedura è costituito dalla divisione del territorio italiano

Poggi, Davide

188

The Adopt-a-Herring program as a fisheries conservation tool [El programa "adopta un s??balo" como herramienta de conservaci??n en pesquer??as  

USGS Publications Warehouse

Successful conservation depends on a scientifically literate public. We developed the adopt-a-Herring program to educate nonscientists about fisheries and watershed restoration. this interactive educational and outreach project encouraged coastal residents to be involved in local watershed restoration. In the northeastern United States, river herring (Alosa spp.) are an important component of many coastal watersheds and often are the object of conservation efforts. In order to understand river herring spawning behavior and to improve the effectiveness of restoration efforts, our research tracked these fish via radiotelemetry in the Ipswich River, Massachusetts. In our adopt-a-Herring Program, participating stakeholder organizations adopted and named individual tagged river herring and followed their movements online. We also made information available to our adopters on our larger research goals, the mission and activities of other research and management agencies, examples of human actions that adversely affect watersheds, and opportunities for proactive conservation. Research results were communicated to adopters through our project web page and end-of-the-season summary presentations. Both tools cultivated a personal interest in river herring, stimulated discussion about fisheries and watershed restoration, educated participants about the goals and methods of scientists in general, and initiated critical thinking about human activities that advance or impede sustainability.

Frank, H.J.; Mather, M.E.; Muth, R.M.; Pautzke, S.M.; Smith, J.M.; Finn, J.T.

2009-01-01

189

SERVICIO DE DEPORTES NORMATIVA DE ACTUACIN DEL  

E-print Network

SERVICIO DE DEPORTES NORMATIVA DE ACTUACI�N DEL PERSONAL AUXILIAR DE INSTALACIONES DEPORTIVAS CULTURA, DEPORTES Y POLÍTICA LING�ÍSTICA 3 NORMATIVA DE ACTUACI�N DEL PERSONAL AUXILIAR DE INSTALACIONES VICERRECTORADO DE CULTURA, DEPORTES Y POLÍTICA LING�ÍSTICA 4 · Entrega de las llaves de los vestuarios al

Escolano, Francisco

190

Mercato del carbonio e settore forestale: buone  

E-print Network

'ambito del PK D. Le scelte del Governo italiano Definizioni · 1 credito = 1 t CO2 equivalente (eq) · Eq = il in equivalenti di CO2 · 1 t C eq = 3,66 t CO2 eq #12;11-10-2012 2 Regole e buone prassi · MARC Quando si opera

Pettenella, Davide

191

Aspectos macroeconómicos del plan de desarrollo  

Microsoft Academic Search

Poco después de la apertura, la economía inició un ciclo de crecimiento rápido y acumulación de déficits, seguido por otra etapa de correctivos monetarios que frenan el crecimiento, pero que no eliminan las causas del desiquilibrio. El Plan de Desarrollo reduce el déficit fiscal y es probable que la próxima fase de expansión dure 3 años, en lugar del año

Luis Lorente

1999-01-01

192

Teoría del discurso y derechos humanos  

Microsoft Academic Search

En esta obra Alexy desarrolla su fundamentación de las decisiones judiciales o teoría de la argumentación jurídica. Su concepción es eminentemente racional y parte de la teoría del discurso de Habermas, en el intento de lograr un modelo de argumentación jurídica que corresponda al Estado constitucional democrático. La singularidad del punto de vista que aquí expone radica en que considera

Robert Alexy

193

CAPÍTULO 4. ANÁLISIS DEL DISCURSO: DISCURSO DEL EMPERADOR HIROHITO CON MOTIVO DE LA RENDICIÓN DE JAPÓN DE LA GUERRA DEL PACÍFICO  

Microsoft Academic Search

El ACD se encuadra en el marco teórico del Análisis del Discurso, teoría que otorga al discurso la dimensión de práctica social. En el ACD se explota esta vertiente social del uso del lenguaje, profundizando en las relaciones sociales e ideológicas que se establecen entre el texto y el contexto. El discurso se concibe como un concepto tridimensional: discurso como

Raquel Rubio Martín

194

¿Cómo puedo usar los servicios del CIS?  

Cancer.gov

El Servicio de Información sobre el Cáncer del Instituto Nacional del Cáncer maneja también la línea telefónica para dejar de fumar 1-877-448-7848 (1-877-44U-QUIT), la cual proporciona información gratuita para dejar de fumar y apoyo a fumadores que desean dejar el tabaco. Nuestro servicio no tiene ningún costo ni cuota de pago. El servicio se brinda en inglés y en español, de lunes a viernes de 8 de la mañana a 8 de la noche, hora del Este.

195

Caracas: Escenario del mundo (V Festival Internacional de Teatro)  

E-print Network

Guerra Mundial. EL TEATRO IRREVERENTE DEL BRASIL: UNA EPOPEYA TROPICAL Pero si hubo un conjunto dramático que casi ocasiona un motín a la en trada del teatro ese fue el Grupo Macunaíma del Brasil con su obra Macu- naíma basada en la novela homónima del...

Má rceles Daconte, Eduardo

1981-10-01

196

Un analisis internacional del gasto publico en educacion  

Microsoft Academic Search

En este trabajo analizamos la evolucion del gasto en educacion en 9 paises de la OCDE en el periodo 1985-92. Se estudia la trayectoria del gasto en educacion en %PIB y en funcion del numero de alumnos, relacionado ambos con la capacidad economica de cada pais expresada a traves del PIB per capita. Mediante de un modelo econometrico analizamos la

Ana Iglesias; Isabel Neira

1996-01-01

197

Departamento de Filosofa del Derecho y Derecho Internacional Privado Presentacin  

E-print Network

Departamento de Filosofía del Derecho y Derecho Internacional Privado Presentación El Departamento de Filosofía del Derecho y Derecho Internacional Privado está compuesto por las siguientes áreas de personalizada, los profesores del Departamento de Filosofía del Derecho y Derecho Internacional Privado ruegan

Escolano, Francisco

198

Teatro chileno en la década del 80  

E-print Network

la lucha moral intimista, como el clásico Deja que los perros ladren, de Sergio Vodanovic. Aunque el teatro chileno desdeñó SPRING 1992 83 habitualmente del panfleto más efectista, sí tuvo un compromiso con las grandes utopías y demandas... su producción conjunta y no existir esa clásica separación de roles, al borrarse las fronteras, también se han aminorado los conflictos y las angustias de ambas partes. Estas tres caracterizaciones del teatro chileno de los últimos años—teatro de...

Piñ a, Juan André s

1992-04-01

199

COLOMBIA: El IV Festival del Nuevo Teatro  

E-print Network

cabeza de Gu\\up, reúne y elabora todas sus experiencias anteriores, superando fracasos y desarrollando necesidades del público callejero. Es una creación colectiva basada en una imagen del Popól Vuh10 con texto de Juan Carlos Moyano, dirección de Jorge.... Gabriel García Márquez, Todos los cuentos de Gabriel García Márquez (La Habana: Casa de las Américas, 1968), pp. 268-277. Colección La Honda. 10. Popol Vuh, Antiguas historias de los indios quichés de Guatemala (Mexico: Editorial Porrúa, 1965). Cabe...

Gonzá lez, Patricia E.

1980-10-01

200

rgano informativo del Colegio de Ciencias y Humanidades Suplemento especial  

E-print Network

Número 3 9 de mayo de 2011 �rgano informativo del Colegio de Ciencias y Humanidades SuplementoCCHSuplementoespecialnúmero3,9demayode20114 La Dirección General del Colegio de Ciencias y Humanidades, a través del elementos básicos del método epidemi- ológico para su aplicación en curso de Ciencias de la Salud, del nivel

Islas, León

201

Serie de Derecho Económico 1. Casos de estudio de aplicación del Análisis Económico del Derecho  

Microsoft Academic Search

El interés por el estudio del Análisis Económico del Derecho –AED– no es nuevo. En su versión clásica, que corresponde a la Escuela de Chicago, y también en las versiones más recientes como la nueva economía institucional, el AED resulta ser una herramienta útil para estudiar problemas jurídicos, la forma de incidir de la regulación en el desarrollo y en

Varios

202

Dr. Matas Alvarado (CV breve) Investigador Titular del Departamento de Computacin del CINVESTAV; Miembro Regular de  

E-print Network

Dr. Matías Alvarado (CV breve) Investigador Titular del Departamento de Computación del CINVESTAV. JOS� MATÍAS ALVARADO MENTADO Curriculum Vitae DATOS PROFESIONALES Investigador CINVESTAV 3B (Febrero JCR ISI 1. Alvarado Matias, Sheremetov, L., Bañares, R. & Cantú, F. (Guest Eds.) Special Issue

Alvarado, Matías

203

La capacidad de carga psicológica del turista como indicador del turismo sostenible  

Microsoft Academic Search

La capacidad de carga turística ostenta un interés creciente dado que se vincula estrechamente con el desarrollo turístico sostenible. Se preten- de justificar la utilidad de este concepto mediante una propuesta metodo- lógica sencilla y eficaz, analizando la capacidad de carga psicológica del turista. En la aplicación empírica se detecta que la satisfacción del turista disminuye cuando los niveles de

Jesús Manuel López Bonilla; Luis Miguel; López Bonilla

204

El uso del agua en Níjar: Implicaciones ambientales del modelo actual de gestión  

Microsoft Academic Search

RESUMEN Níjar, municipio del SE almeriense, experimenta, hoy por hoy, una coyuntura de escasez del agua sin precedentes. El modelo de gestión actual, basado en la explotación de las aguas subterráneas, y protagonizado por una agricultura intensiva en crecimiento y una incipiente actividad turística, ha conducido al progresivo agotamiento de los acuíferos locales. En respuesta a tal coyuntura, se implementan

Francisco Javier Toro Sánchez

2008-01-01

205

Las representaciones fácticas y cognitivas del relato de entrevistas biográficas : un análisis reticular del discurso  

Microsoft Academic Search

Este artículo trata de identificar y relacionar las dimensiones fácticas y cognitivas de un relato biográfico, entendido como una representación narrativa. El entrevistado construye su narración entreverando ambas dimensiones a lo largo del relato. Este artículo propone un método de análisis reticular del discurso como un procedimiento eficaz para poner de relieve y relacionar ambas dimensiones. A partir de teorías

Carlos Lozares Colina

2006-01-01

206

Terapias con inhibidores del receptor del factor de crecimiento epidérmico: acercando el futuro  

Microsoft Academic Search

RESUMEN La función esencial del receptor del factor de crecimiento epidérmico (REGF) en diversos tipos de tumores sólidos lo ha convertido en un blanco fundamental para el diseño de nuevas drogas. La contribución de las vías de señalización asociadas al REGF en procesos tumorales como la proliferación celular, la angiogénesis y la resistencia a apoptosis ha sido bien establecida. Dos

Arlhee Díaz; Agustín Lage

2007-01-01

207

Preguntas y respuestas acerca del Estudio del Tamoxifeno y Raloxifeno (STAR)  

Cancer.gov

El Estudio del Tamoxifeno y Raloxifeno (STAR, por sus siglas en inglés) es un estudio clínico (un estudio de investigación conducido con voluntarios) diseñado para ver cómo el medicamento raloxifeno (Evista®) se compara con el medicamento tamoxifeno (Nolvadex®) en reducir la incidencia de cáncer del seno en las mujeres con alto riesgo de desarrollar la enfermedad.

208

Intertextual Sexual Politics: Illness and Desire in Enrique Gomez Carrillo's "Del amor", "del dolor y del vicio" and Aurora Caceres's "La rosa muerta"  

ERIC Educational Resources Information Center

This study explores the intertextuality between Aurora Caceres's "La rosa muerta" (1914) and the novel "Del amor, del dolor y del vicio" (1898) by her ex-husband, Enrique Gomez Carrillo. Caceres strategically mentions Gomez Carrillo's novel in "La rosa muerta" to invite a reading of her work in dialogue with his. Both narratives follow the sexual…

LaGreca, Nancy

2012-01-01

209

El teatro en el XVII Congreso del IILI en Filadelfia  

E-print Network

42 LATIN AMERICAN THEATRE REVIEW El teatro en el XVII Congreso del IILI en Filadélfia La segunda parte del XVII Congreso de Literatura Iberoamericana del In stituto Internacional de Literatura Iberoamericana se celebró en la Universidad de... Pennsylvania, en Filadélfia, durante la semana del 24 al 29 de agosto de 1975 (la primera de había efectuado en Madrid y Sevilla del 20 al 26 de marzo de dicho año—véase LATR, 8/2, Spring 1975, pág. 50). El tema del congreso fue el su rrealismo y la...

Gutié rrez de la Solana, Alberto

1976-04-01

210

Extensión del Formalismo de Orbitales de Defecto Cuántico al tratamiento del efecto Stark (SQDO).  

NASA Astrophysics Data System (ADS)

El estudio experimental de las interacciones de átomos Rydberg altamente excitados con campos eléctricos ha experimentado un creciente interés durante las dos últimas décadas debido, en gran medida, al desarrollo de nuevas técnicas para crear y estudiar átomos Rydberg en el laboratorio. Acompañando a estas nuevas técnicas experimentales, es necesario el desarrollo de modelos teóricos que nos permitan contrastar sus medidas y conocer mejor los fundamentos de los mismos. Desde el punto de vista teórico el conocimiento del desdoblamiento de los niveles energéticos de un átomo en función de la magnitud del campo eléctrico aplicado (lo que se conoce como mapa Stark) es el mejor punto de partida para la descripción del sistema y un prerrequisito fundamental para el cálculo de distintas propiedades atómicas en presencia del campo eléctrico tales como intensidades de transición, umbrales de ionización de campo eléctrico, tiempos de vida, posición y anchura de cruces evitados, etc. En este trabajo presentamos la adaptación del método de orbitales de defecto cuántico [1,2,3] al tratamiento del efecto Stark (SQDO) [4] y su aplicación al cálculo de los desdoblamientos energéticos y fuerzas de oscilador de estados Rydberg en los átomos de Li, Na y K. El propósito de este estudio es, por un lado, desarrollar métodos fiables para la determinación de propiedades atómicas en presencia de campos eléctricos y, por otro, mostrar la fiabilidad de las funciones de onda QDO en la descripción del efecto Stark en sistemas atómicos.

Menéndez, J. M.; Martín, I.; Velasco, A. M.

211

III Festival del Siglo de Oro (Chamizal)  

E-print Network

SPRING 1978 111 III Festival del Siglo de Oro (Chamizal) E. JARABA-PARDO El Siglo de Oro fue, por la fecundidad de los autores y por las influencias trascendentales de sus obras en el posterior desarrollo de la dramaturgia universal, uno de los... períodos más importantes en la historia del teatro. Algunos de sus rasgos esenciales fueron el uso de un lenguaje popular, satírico, e irónico, la introducción de personajes de las clases bajas, tales como esclavos y sirvientes, y la irreverencia a las...

Jaraba-Pardo, E.

1978-04-01

212

Transformación de los programas de estudios clínicos del NCI  

Cancer.gov

Información sobre los programas e iniciativas del NCI que patrocinan, realizan, crean o apoyan estudios clínicos, entre los que se incluyen la Red Nacional de Estudios Clínicos (NCTN) y el Programa de Investigación Oncológica Comunitaria (NCORP) del NCI.

213

PROGRAMMA DEL CORSO "Teoria dei Modelli" DOCENTE: Alessandro Berarducci  

E-print Network

PROGRAMMA DEL CORSO "Teoria dei Modelli" DOCENTE: Alessandro Berarducci Anno di corso: 2009 CONTENUTI DELL'INSEGNAMENTO: Introduzione alle nozioni fondamentali della teoria dei modelli con compagne. Amalgamazione ed eliminazione dei quan- tificatori. Teoria degli ordini discreti. Teoria del

Berarducci, Alessandro

214

Student Competition: Siting Potential Dams at Camp Del Webb, Utah  

E-print Network

Siting Potential Dams at Camp Del Webb, Utah Presented By: Kyle Wamser Problem ? Camp Del Webb is Lacking an Onsite Lake ? High Adventure Bases generally need aquatics ? Large lake nearby, but transportation is required ? Possible Solution...

Wamser, William Kyle

2007-11-14

215

Centro para la Salud Mundial (CGH) del NCI  

Cancer.gov

El Centro para la Salud Mundial (CGH) del Instituto Nacional del Cáncer coordina actividades de investigación y trabaja con socios nacionales e internacionales para comprender y enfrentar la carga que representa el cáncer a nivel mundial.

216

La evolución estilística del teatro de Aguilera-Malta.  

E-print Network

centroamericano de administración y clientela blanca y de músicos negros, en esta pieza el autor reprueba franca mente, aunque con la lenificación que proveen la ironía del desenlace y lo espectacular del breve cuadro, la discriminación practicada contra el...

Luzuriaga, Gerardo

1970-04-01

217

Memorias del Segundo Simposio Internacional Sobre Polticas, Planificacin y Economa de los Programas de Proteccin Contra Incendios Forestales: Una Visin Global Memorias del Segundo Simposio Internacional Sobre Polticas, Planificacin y Economa de los Progra  

E-print Network

combustible entre las zonas forestales y las áreas de colindancia urbano-forestal? ¿Podemos lograr una. de Econ. Ag., 51 Campus Drive, University of Saskatchewan, Saskatoon, SK S7N 5A8. 3 National Center

Standiford, Richard B.

218

Analisis cuantitativo del gasto en educacion en Europa  

Microsoft Academic Search

El objetivo de este trabajo es analizar la situacion del gasto publico total en educacion para nueve paises de la OCDE entre los que se encuentra España, en el periodo 1985-1992. Para ello comparamos el gasto en estos paises desde diferentes perspectivas, en funcion del PIB, gasto por alumno, porcentaje del gasto en los diferentes niveles educativos sobre el total,

Isabel Neira; M. Carmen Guisan; X. A. Rodriguez

1997-01-01

219

APORTES TEÓRICO-METODOLÓGICOS PARA EL ESTUDIO DE LA PRODUCCIÓN SOCIAL DE SENTIDO A TRAVÉS DEL ANÁLISIS DEL DISCURSO PRESIDENCIAL  

Microsoft Academic Search

Este artículo presenta un enfoque teórico-metodológico para el estudio de las significaciones políticas. Se apunta a contribuir a la reflexión acerca del papel del discurso presidencial en la construcción de una \\

Víctor Armony

2005-01-01

220

UNIVERSIDAD SIMON BOLIVAR SEDE DEL LITORAL  

E-print Network

POSTGRADO DENOMINACI�N: C�DIGO: ASIGNATURA: REDES DE DATOS (Capas 1, 2 y 3) TI-7312 REQUISITOS: TRANSMISI�N: Al finalizar la asignatura Redes de Datos (Capas 1, 2 y 3), el estudiante deberá manejar los conceptos básicos relacionados con las comunicaciones en las redes de datos en las capas 1, 2 y 3 del modelo

Vásquez, Carlos

221

Near Infrared Photometry of Nova Del 2013  

NASA Astrophysics Data System (ADS)

We continued to follow Nova Del 2013 during the period from 31.15 August 2013 UT through 25.18 September 2013 UT using an As:Si bolometer mounted on the 0.76-m infrared telescope of the University of Minnesota's O'Brien Observatory (Marine on St. Croix, Minnesota, USA). Vega (alpha Lyrae) is used as the standard star.

Cass, A. C.; Carlon, R. L.; Corgan, D. T.; Dykhoff, D. A.; Gehrz, R. D.; Shenoy, D. P.

2013-09-01

222

El impacto macroeconómico del control de importaciones  

Microsoft Academic Search

A pesar de su uso generalizado como instrumento de política económica, tanto en los países desarrollados (entre las décadas del treinta y el cincuenta y nuevamente en los años setenta) como en las naciones en vía de desarrollo, los controles directos a las importaciones han tenido una vida teórica clandestina. Esto refleja, no sólo el recelo de los economistas neo-clásicos

José Antonio Ocampo

1985-01-01

223

Aproximaciones al análisis económico del derecho  

Microsoft Academic Search

Durante las últimas décadas la metodología de estudio que plantea el análisis económico del Derecho ha tomado gran importancia en todo el mundo,y es acompañada y respaldada por un prolífico volumen de publicaciones e investigadores, que día tras día la utilizan para evaluar los posibles caminos y consecuencias que las construcciones y desarrollos legales pueden tener sobre el comportamiento de

Mario A. Pinzón Camargo

224

GEOGRAFAAGRARIA (1 parte del Tema 1)  

E-print Network

parcelas Límites #12;EL SECANO El riego se limita a las aportaciones del agua de lluvia. La cantidad de lluvia caída matiza los secanos de las distintas áreas climáticas. Es posible dividir los secanos en dos

Escolano, Francisco

225

POLÍTICA TURÍSTICA DEL DEPARTAMENTO DE ANTIOQUIA  

Microsoft Academic Search

La importancia de la políticas para el adecuado desarrollo de la actividad turística es mayor de lo que normalmente se considera (Torres, 2004). Las autoridades regionales y locales desempeñan un papel fundamental en la formulación de políticas y en la organización y desarrollo del turismo. Esto ha sido durante mucho tiempo el caso de países como Alemania, Estados Unidos o

Claudia María Giraldo Velásquez; Sandra Zapata Aguirre

2010-01-01

226

akihiro kanamori L'ipotesi del continuo*  

E-print Network

tutti questi passi nel contesto di quei progressi fondamentali che hanno condotto alla moderna teoria ­ sarebbe diventato il più rilevante problema della teoria degli insiemi. Di più: lo sviluppo della teoria, sarebbe stato guidato dal problema del con- tinuo. In tutti i momenti critici in cui tale teoria si è

Kanamori, Akihiro

227

LA DIRECCIÓN DEL PROCESO DE INNOVACIÓN  

Microsoft Academic Search

RESUMEN El proceso de diseño y desarrollo de un nuevo producto es, en la actualidad, para las em- presas, una de las más importantes fuentes de ventajas competitivas sostenibles a largo plazo. Sin embargo, para innovar, la empresa debe situarse fuera del equilibrio. Es precisamente la gran incer- tidumbre que caracteriza a este tipo de actividades, la que causa, que

García Rodríguez

1998-01-01

228

Stato di avanzamento del lavoro di tesi  

E-print Network

Stato di avanzamento del lavoro di tesi Luca Malagoli Dipartimento di Fisica e Tecnologie Relative in attesa di pubblicazione · Le scuole di storia della fisica, (con C.Romagnino), in uscita su La fisica for the history of Sciences · Premio Nobel per la fisica 2008: un caso paradigmatico per la storia della fisica

Spagnolo, Filippo

229

Facultad de Derecho DATOS DEL ALUMNO  

E-print Network

Facultad de Derecho DATOS DEL ALUMNO APELLIDOS 1º 2º NOMBRE NIF DIRECCI�N LOCALIDAD CP PROVINCIA EMAIL TFNO. FIJO TFNO. MOVIL IMPORTANTE Para obtener los correspondientes títulos de Derecho y ADE, el elección, con los siguientes requisitos: - Los créditos de libre elección necesarios son 30,5 para Derecho

Escolano, Francisco

230

Del Mod System. 1972 Annual Report.  

ERIC Educational Resources Information Center

The overall aim of the Del Mod System is the improvement of science programs taught in Delaware schools; it is a working agreement among the University of Delaware, Delaware Technical and Community College, Delaware State College, State Department of Public Instruction, industry, and the schools. It was formed to bring about changes in science…

Purnell, Charlotte H.

231

MINOR DE COMPUTACION CIENTIFICA Nombre del Minor  

E-print Network

1 MINOR DE COMPUTACION CIENTIFICA Nombre del Minor Computación Científica Nombre en Inglés resuelve problemas científicos y/o de ingeniería seleccionando y utilizando las tecnología computacional

Rapaport, Iván

232

Elezione del Direttore del Dipartimento di Matematica Elenco provvisorio degli aventi diritto I affissione  

E-print Network

" BELTRAMETTI MAURO CLAUDIO " BOTTARO GIANFRANCO " BURLANDO LAURA " CONCA ALDO " GERAMITA ANTHONY VITO VERME FILIPPO " DE NEGRI EMANUELA " DEL PRETE VICENZA " DI BENEDETTO FABIO " GUALA ELDA " MORA FULVIO PAMELA " PERAZZO CECILIA " OLIVERI PAOLO " VERBOSIO FABIO " ONETO ALESSANDRO " TOZZO LAURA " CALEO

Robbiano, Lorenzo

233

Vigilando la Calidad del Agua de los Grandes Rios de la Nacion: El Programa NASQAN del Rio Grande (Rio Bravo del Norte)  

USGS Publications Warehouse

La Oficina del Estudio Geologico de los Estados Unidos (U.S. Geological Survey, 0 USGS) ha monitoreado la calidad del agua de la cuenca del Rio Grande (Rio Bravo del Norte) desde 1995 como parte de la rediseiiada Red Nacional para Contabilizar la Calidad del Agua de los Rios (National Stream Quality Accounting Network, o NASOAN) (Hooper and others, 1997). EI programa NASOAN fue diseiiado para caracterizar las concentraciones y el transporte de sedimento y constituyentes quimicos seleccionados, encontrados en los grandes rios de los Estados Unidos - incluyendo el Misisipi, el Colorado y el Columbia, ademas del Rio Grande. En estas cuatro cuencas, el USGS opera actualmente (1998) una red de 40 puntos de muestreo pertenecientes a NASOAN, con un enfasis en cuantificar el flujo en masa (la cantidad de material que pasa por la estacion, expresado en toneladas por dial para cada constituyente. Aplicacando un enfoque consistente, basado en la cuantificacion de flujos en la cuenca del Rio Grande, el programa NASOAN esta generando la informacion necesaria para identificar fuentes regionales de diversos contaminantes, incluyendo sustancias qui micas agricolas y trazas elementos en la cuenca. EI efecto de las grandes reservas en el Rio Grande se puede observar segun los flujos de constituyentes discurren a 10 largo del rio. EI analisis de los flujos de constituyentes a escala de la cuenca proveera los medios para evaluar la influencia de la actividad humana sobre las condiciones de calidad del agua del Rio Grande.

Lurry, Dee L.; Reutter, David C.; Wells, Frank C.; Rivera, M.C., (translator); Munoz, A.

1998-01-01

234

El Efecto De Los Atentados Del 11-s Sobre El Turismo En España  

Microsoft Academic Search

El objetivo del trabajo es analizar las consecuencias que los atentados del 11-S han tenido sobre los flujos turísticos en España. El marco teórico utilizado se inspira en el modelo del comportamiento racional del consumidor desarrollado por Enders et al. (1992), en el se incluye el estudio de los efectos del terrorismo sobre la actividad del sector turístico. El estudio

BERNARDÍ CABRER BORRÁS; DAVID IRANZO PÉREZ

2007-01-01

235

Arquitectura del Sistema de Gestin del ancho de Banda y Proteccin (SGBP) para entornos de redes  

E-print Network

Arquitectura del Sistema de Gestión del ancho de Banda y Protección (SGBP) para entornos de redes de banda y protección para entornos de redes MPLS. El sistema está formado por dos módulos, el de de banda. 1. Introducción La evolución de las tecnologías de las comunicaciones hacia redes de

Ortega, Eusebi Calle

236

COMPORTAMENT DEL PAS DEL CAMPUS DE LA UIB, EN REFERNCIA A LA MOBILITAT  

E-print Network

PARTICIPACI� VA SER MOLT ELEVADA 2. LA MILLORA DE LA CARRETERA, L'AVARIA DEL METRO EL CURS 2007-2008 I L; 39,9% Bus, Metro; 24; 16,8% Bus, Metro, Tren; 1; 0,7% Metro; 36; 25,2% Metro, Tren; 21; 14,7% Taxi, Metro, Bus; 1; 0,7% Taxi, Tren, Metro, Bus; 1; 0,7% Tren; 2; 1,4% ·Veient l'absurd dels resultats s

Oro, Daniel

237

MIQUEL DELS SANTS OLIVER EN EL 150 ANIVERSARI DEL SEU NAIXEMENT  

E-print Network

MIQUEL DELS SANTS OLIVER EN EL 150è ANIVERSARI DEL SEU NAIXEMENT (Campanet, 1864 ­ Barcelona, 1920'anàlisi de la personalitat i l'obra d'Oliver. Primerament hi haurà una jornada d'estudi, l'objectiu de la impartirà una conferència a la seu de la Societat Arqueològica Lul·liana, entitat de la qual Oliver va ser

Oro, Daniel

238

Víctimas y victimarios: Cómplices del discurso del poder en Una noche con el Sr. Magnus e hijos de Ricardo Monti  

E-print Network

FALL 1989 37 Víctimas y victimarios: Cómplices del discurso del poder en Una noche con el Sr. Magnus e hijos de Ricardo Monti Roberto Previdi Froelich ... porque nunca podemos odiar a las personas que sabemos son capaces de hacer exactamente... en los lados ocultos que encarnan la sutil naturaleza de la ideología burguesa en su discurso del poder. Si bien presenciamos una evidente ruptura con una construcción tradicional del realismo teatral,1 el teatro de Monti, a través de sus...

Previdi Froelich, Roberto

1989-10-01

239

Estudio para la prevención del cáncer necesita voluntarias: El Estudio del Tamoxifeno y Raloxifeno (STAR) se realiza en Norteamérica  

Cancer.gov

El Estudio del Tamoxifeno y Raloxifeno (STAR, por sus siglas en inglés), uno de los estudios más importantes realizados para la prevención del cáncer del seno, está ahora reclutando voluntarias en más de 400 centros en los Estados Unidos, Puerto Rico y Canadá.

240

Son Bosc, un dels tresors de Mallorca, en perill!  

E-print Network

ELÃ?CTRICA DE ESPAÃ?A MW 04:27 hr. 434.6 850.9 21:24 hr. 04:50 hr. 10:25 hr. 04:51 hr. 21:40 hr. 21:47 hr. 06:39 hr. 04:51 hr. 21:38 hr. 04:30 hr. 21:40 hr. 04:42 hr. 11:06 hr. 437.2 822.7 439.8 793.0 765.9 416 insec- tos, hay muchas aves. Toda la zona de Son Bosc es muy rica, a cada nivel. No puedo imaginarme que

Traveset, Anna

241

Monitor de Pilates Programa del curso  

E-print Network

práctica deportiva · Lcdo. Ciencias de la Actividad Física y el Deporte · Especialista en Salud y práctica. · Revisor Científico: · Revista Andaluza Medicina Deporte · Revista PubliCE Standard (ISSN 1667-4030) y · Miembro Honor Federación Dominicana Medicina del Deporte · Galardón Nacional al Mérito Deportivo Intergyms

Escolano, Francisco

242

La evolucion del modernismo en Puerto Rico  

E-print Network

a echar raices para el 1911. La produccion modernista se recogio en las revistas Puerto Rico ilustrado (1910 hasta la actualidad) y muy en especial, en la Revista de las Antillas (1913-1914). Varios fueron los poetas que sobresalieron dentro del.... Pero su produccion no se limita a estas tres obras; Ruben Dario cultivo varios generos literarios corno lo son el cuento poematico, la prosa, la cronica, el libro de viajes y la semblanza biografica mezclada con el comentario critico (Lazo 29...

Gonzalez-Hernandez, Miriam Mercedes

1989-01-01

243

II Taller Centroamericano y del Caribe: Guatemala  

E-print Network

Ricardo 152 LATIN AMERICAN THEATRE REVIEW Mendoza, salvadoreño radicado en Costa Rica; Maquillaje, por Damián Félix, panameño y finalmente Danza Teatro por María Méndez quien trabaja en Grecia, pero está de asueto en Guatemala. Hubo diferentes paneles... fueron: Ricardo Martínez, dramaturgo y director; Ligia Méndez, actriz y promotora cultural; Fernando Meneos, actor, director y docente teatral y Guillermo Ramírez, director y productor, presidente de la Asociación Guatemalteca de Trabajadores del...

Bravo-Elizondo, Pedro

1991-10-01

244

Premio Ollantay 1989 - Acta del jurado  

E-print Network

, personas e instituciones cuyas trayectorias, dedicadas al desarrollo del teatro a nivel continental, ameriten ser destacadas como ejemplo. El Jurado designado por el CELCIT para otorgar los Premios Ollantay correspondientes al año 1989, integrado por... Colombia 2. Grupo de Teatro al Teatro Imagen, de Chile 3. Institución de Apoyo al Teatro al Consejo Nacional de Ciencia y Tecnología, CONCYTEC, de Perú 4. Teatro Infantil al Grupo de Teatro de Muñecos "Quijotillo," de Cumaná, Venezuela 5. Publicación...

Editors

1990-04-01

245

Morphology, geology and geochemistry of the "Salar del Gran Bajo del Gualicho" (Rio Negro, Argentina)  

USGS Publications Warehouse

A multidisciplinary study of the Gran Bajo del Gualicho area (Rio Negro - Argentina) was carried out; the aim was to delineate its geological and geomorphological evolution and to estabilish the genesis of salts filling the depression. Climatic conditions were analized first to individuate their role in the present morphogenetic processes; moreover the main morphological features of present landscape were examined as well as the stratigraphy of the outcropping formations, and of the Gran Bajo del Gualicho Formation in particular. Finally, a possible geomorphological evolution of the studied area was traced. Geophysical analyses allowed to estabilish that the paleosurface shaped on the crystalline basement is strongly uneven and shows evidence of the strong tectonic phases it underwent. The result of isotope analyses confirmed that the salt deposits on the Gran Bajo del Gualicho bottom were produced by fresh water evaporation, while strontium isotope ratio suggested that such waters were responsible for solubilization of more ancient evaporitic deposits.

Angelucci, A.; Barbieri, M.; Brodtkorb, A.; Ciccacci, S.; Civitelli, G.; De Barrio, R.; Di, Filippo M.; Fredi, P.; Friedman, I.; Lombardi, S.; Schalamuk, A.I.; Toro, B.

1996-01-01

246

Influencia del talento del empresario y del tipo de página web en los resultados empresariales para las casas de turismo rural en España  

Microsoft Academic Search

El Turismo rural ha alcanzado un auge muy fuerte en España e internet se ha convertido en una herramienta vital en el sector. En este trabajo se persigue: 1) analizar la importancia del talento del empresario en la implantación de páginas web; 2) examinar la influencia de este talento y de las características de la página web sobre los resultados

Jannine Waleska; Nieto Arias; Rosa María; Hernández Maestro; Pablo A. Muñoz Gallego

247

Propuesta metodológica para la evaluación del impacto de la contaminación de las cuencas hídricas del país: Estudio de caso del río “La vieja”  

Microsoft Academic Search

El presente estudio estuvo enfocado en la generación de una metodología general dirigida a cuantificar el impacto socioeconómico de la contaminación de las cuencas hídricas tomando como caso particular la Cuenca del Río La Vieja y a la población de Cartago (Valle del Cauca). Los tópicos desarrollados en este trabajo de investigación se pueden resumir en los siguientes aspectos: En

Alfredo SARMIENTO; Darwin Marcelo GORDILLO; Juan Miguel VILLA

2005-01-01

248

Red de Bibliotecas del CSIC. Estadsticas. Prstamo personal 2010 http://bibliotecas.csic.es 1  

E-print Network

Código Biblioteca Préstamos Lectores Activos Préstamos por lector AL-EEZA Estación Experimental de Zonas 83 2,80 M-CENQUIOR Centro de Química Orgánica "Lora Tamayo" 231 92 2,51 M-CETEF Centro de Tecnologías

249

UNIVERSIDAD NACIONAL AUTNOMA DE MXICO Datos del plan de estudio  

E-print Network

Pruebas de Evaluación Psicológica en el Deporte Dirigido a: Entrenadores de la DGADyR, Comunidad el psicólogo del deporte debe obtener los índices del estado psicológico de los deportistas, lo que así como las técnicas utilizadas en psicología del deporte para modelar las características

Islas, León

250

La profesionalización del teatro nacional argentino. Un precursor: Nemesio Trejo  

E-print Network

acuerdo a las ineludibles reglas del mercado que el incipiente capitalismo había impuesto en la economía argentina. Los productores del mensaje teatral pertenecían en su mayoría a esa nueva promoción de escritores profesionalizados, provenientes de las.... Estas dos profesiones fueron asumidas en su vida con pasión y consciente de "la flagrante evidencia de la nueva economía de la época finisecular: la instauración del mercado," como apunta acertadamente Ángel Rama acerca de los poetas modernistas (1...

Pellarolo, Silvia

1997-10-01

251

El Sexto Festival de Teatro Español del Siglo de Oro  

E-print Network

SPRING 1981 79 El Sexto Festival de Teatro Español del Siglo de Oro Arturo Pérez-Pisonero El Sexto Festival de Teatro Español del Siglo de Oro, celebrado en el Chamizal National Memorial en las fechas del 6 al 22 de marzo, ha presen tado, como... en años anteriores, un muy variado programa de grupos profe sionales y aficionados. La nutrida participación ha demostrado, en muchos casos, más entusiasmo que habilidad por parte de directores y actores para resolver la compleja problemática que...

Pé rez-Pisonero, Arturo

1981-04-01

252

La generación de 1924: El dilema del realismo  

E-print Network

preocupaciones existenciales visibles en la poesía del autor: la autenticidad individual, la relatividad, el dilema solipsista. Lo fascinante es que las dos obras están concebidas dentro del teatro realista; son como variantes a la temática consabida del lío...) da el paso definitivo. Se emplean máscaras y un prólogo hablado directamente al público, predominan las escenas de dos personajes y en general una estructura que recuerda la de la tragedia griega. Porque de eso se trata: Cuauhtemoc es una...

Dauster, Frank

1985-04-01

253

DERECHOS DEL EMPLEADO LEy PARA LA PROtECCin  

E-print Network

DERECHOS DEL EMPLEADO LEy PARA LA PROtECCión DEL EMPLEADO COntRA LA PRuEbA DEL POLígRAfO PROHIBICIONES ExENCIONES DERECHOS DE LOS ExAMINADOS CUMPLIMIENTO Generalmente se le prohíbe al empleador que le aspirante a un trabajo por haberse negado a someterse a la prueba o por haberse acogido a otros derechos

Rock, Chris

254

A Description of Del Mod and Its Final Evaluation, Final Report, Volume I.  

ERIC Educational Resources Information Center

This monograph presents an overview of five Del Mod System final reports, comments by the project director, financial structure of the Del Mod System, and descriptions of Del Mod Projects. The Del Mod System was concerned with changing the science and mathematics education programs in the state of Delaware. Between 1970 and 1976, Del Mod conducted…

Purnell, Charlotte H.; Bolig, John R.

255

Efecto del Programa de Entrenamiento “Manejo del Dolor” en la Documentación de Enfermería en el Expediente Electrónico  

PubMed Central

Resumen En el presente trabajo se muestra la importancia de entrenar al personal de enfermería para mejorar la documentación en el expediente electrónico. Se eligió el manejo del dolor por ser un área prioritaria; una alta proporción de pacientes en período post operatorio cursa con dolor, por lo tanto, la documentación debe ser útil para la toma de decisiones clínicas. Se implementó un programa de entrenamiento denominado “Manejo del Dolor” dirigido al personal de enfermería. Se utilizó la tecnología de la información como herramienta para fortalecer el conocimiento con base en la revisión sistemática de la literatura; el personal de enfermería participante seleccionó la mejor evidencia; posteriormente se trabajó en la transferencia de este conocimiento a la práctica a través del diseño de un protocolo para el manejo del dolor. Se concluye que el conocimiento del manejo del dolor es fundamental para que enfermería documente con mayor precisión sus intervenciones. PMID:24199106

Monsiváis, María Guadalupe Moreno; Guzmán, Ma. Guadalupe Interial; Flores, Paz Francisco Sauceda; Arreola, Leticia Vázquez

2012-01-01

256

Near Infrared Photometry of Nova Del 2013  

NASA Astrophysics Data System (ADS)

Subjects: Infra-Red, Nova We report RIJHKLM photometry of Nova Del 2013 taken on August 28.13 UT using an As:Si bolometer mounted on the 0.76-m infrared telescope of the University of Minnesota's O'Brien Observatory (Marine on St. Croix, Minnesota, USA). Vega (alpha Lyrae) was used as the standard star. On this date we find: R = 5.6 +/- 0.1, I = 5.2 +/- 0.1, J = 4.5 +/- 0.1, H = 4.7 +/- 0.1, K = 4.7 +/- 0.1, L = 3.3 +/- 0.2, M = +1.8 +/- 0.3.

Cass, C. A.; Carlon, L. R.; Corgan, T. D.; Dykhoff, A. D.; Gehrz, D. R.; Shenoy, P. D.

2013-08-01

257

RELACIÓN MÉDICO PACIENTE: DERECHOS DEL ADULTO MAYOR  

PubMed Central

Existen prejuicios en relación con la vejez, incluso entre los profesionales que se dedican a la gerontología. Uno común y peligroso es considerar que los viejos son todos enfermos o discapacitados. La relación médico-paciente es la piedra angular de la práctica y ética médicas. Para alcanzar el respeto por los adultos mayores es necesaria una medicina prudente, basada en una práctica en la cual la reflexión ética y clínica pueda contribuir. Esto último es posible si se hacen valer los derechos del adulto mayor, en particular como paciente para la toma de decisiones. PMID:20379380

Barrantes-Monge, Melba; Rodríguez, Eduardo; Lama, Alexis

2009-01-01

258

Eficiencia y determinantes del funcionamiento del mercado paralelo de divisas en Colombia  

Microsoft Academic Search

El presente trabajo analiza la relación entre el tipo de cambio negro y el oficial, al igual que la eficiencia del mercado paralelo de divisas en Colombia. Con base en datos mensuales para el período 1970-1989, se encontró que la tasa de cambio oficial y paralela estaban cointegradas, lo cual implica que el dólar oficial y el negro mantuvieron una

Santiago Herrera

1990-01-01

259

¿Puede la escuela del siglo XXI educar a los ciudadanos y ciudadanas del siglo XXI?  

Microsoft Academic Search

Los graves problemas de nuestro mundo reclaman una urgente respuesta educativa por parte del sistema escolar, pero esa respuesta no es adecuada, pues dicho sistema sigue funcionando con características muy tradicionales. La educación para la ciudadanía se presenta como una posibilidad de reorientar la educación hacia finalidades más acordes con los retos que ésta debe afrontar actualmente; sin embargo, entre

Francisco F. García Pérez; Nicolás de Alba Fernández

2008-01-01

260

Determinantes del Gasto Público en Educación y Resultados del sistema educativo por Comunidades Autónomas  

Microsoft Academic Search

RESUMEN Este trabajo tiene como objetivo analizar el gasto público en educación y sus principales determinantes por Comunidades Autónomas durante el período 2000-2004. Al mismo tiempo, trata de analizar la incidencia del mismo en términos de los resultados obtenidos por el sistema educativo en las distintas Comunidades Autónomas. ABSTRACT This paper analyzes the regional public spending in education during 2000-2004

Alfonso Utrilla de la Hoz; Carmen Mitxelena Camiruaga

2007-01-01

261

ALGORITMOS DE OPTIMIZACIN APLICADOS AL SEGUIMIENTO DEL MOVIMIENTO ARTICULAR Y LA DIGITALIZACIN AUTOMTICA DEL  

E-print Network

de imágenes es una tarea compleja que supone un alto coste computacional. Este tipo de objetos los estimados, adaptando el coste computacional a los requisitos del problema en cada momento y necesaria para definir la pdf y, por tanto, el alto coste computacional que conlleva

Pantrigo Fernández, Juan José

262

Estudios Geol., 59: 133-144 (2003) REGISTRO DE LOS CAMBIOS DEL NIVEL DEL MAR DURANTE  

E-print Network

EN LAS ISLAS CANARIAS OCCIDENTALES (TENERIFE Y LA PALMA) C. Zazo*, J. L. Goy**, C. Hillaire Tenerife, y consiste en cinco terrazas marinas localizadas entre los O y 18 m (por encima del nivel medio.000 años, sugieren una ligera ten- dencia al hundimiento en la isla de Tenerife y un ligero levantamiento

Long, Bernard

263

FISH and SNP-A karyotyping in myelodysplastic syndromes: improving cytogenetic detection of del(5q), monosomy 7, del(7q), trisomy 8 and del(20q).  

PubMed

Cytogenetic aberrations identified by metaphase cytogenetics (MC) have important diagnostic, prognostic and therapeutic roles in myelodysplastic syndromes (MDS). Fluorescence in situ hybridization (FISH) complements MC by the ability to evaluate large numbers of both interphase and metaphase nuclei. However, clinically practical FISH strategies are limited to detection of known lesions. Single nucleotide polymorphism array (SNP-A)-based karyotyping can reveal unbalanced defects with superior resolution over MC and FISH and identify segmental uniparental disomy (UPD) undetectable by either method. Using a standardized approach, we focused our investigation on detection of -5/del(5q), -7/del(7q), trisomy 8 and del(20q) in patients with MDS (N=52), MDS/myeloproliferative overlap syndromes (N=7) and acute myeloid leukemia (N=15) using MC, FISH and SNP-A karyotyping. The detection rate for del(5q) was 30, 32 and 32% by MC, FISH, and SNP-A, respectively. No single method detected all defects, and detection rates improved when all methods were used. The rate for detection of del(5q) increased incrementally to 35% (MC+FISH), 38% (MC+SNP-A), 38% (FISH+SNP-A) and 39% (all three methods). Similar findings were observed for -7/del(7q), trisomy 8 and -20/del(20q). We conclude that MC, FISH and SNP-A are complementary techniques that, when applied and interpreted together, can improve the diagnostic yield for identifying genetic lesions in MDS and contribute to the better description of abnormal karyotypes. PMID:19758696

Makishima, Hideki; Rataul, Manjot; Gondek, Lukasz P; Huh, Jungwon; Cook, James R; Theil, Karl S; Sekeres, Mikkael A; Kuczkowski, Elizabeth; O'Keefe, Christine; Maciejewski, Jaroslaw P

2010-04-01

264

Instantánea de los cánceres de cerebro y del sistema nervioso central  

Cancer.gov

Información sobre las tendencias de incidencia, mortalidad y financiamiento del NCI sobre los cánceres de cerebro y del sistema nervioso central; así como ejemplos de actividades del NCI y adelantos en la investigación de estos tipos de cáncer.

265

Ciclo de vida del VIH Enlace y fusin: El VIH empieza su ciclo de vida  

E-print Network

inversa convierte la cadena simple del ARN vírico en cadena doble de ADN vírico. Integración: El nuevo ADN integrasa "esconde" el ADN vírico dentro del propio ADN de la célula anfitriona. El ADN del VIH integrado se­800­448­0440. En Internet www.aidsinfo.nih.gov/infoSIDA. mayo del 2005 1 Human DNA HIV DNA ARN del VIH ADN del VIH

Levin, Judith G.

266

Del carnaval como 'metáfora' al teatro de carnaval  

E-print Network

particular, al tema de la fiesta, del carnaval y del caníbal en la literatura y el teatro. Esta preocupación se relaciona, a su vez, con el desarrollo de un diálogo entre el teatro y la antropología, en torno a los dramas sociales, las formas orales o no...

Remedi, Gustavo

2001-04-01

267

La vulnerabilidad fiscal del gasto social: ¿Es Diferente América Latina?  

Microsoft Academic Search

Se utiliza un panel desbalanceado de medio centenar de países para el período 1985-2003 con el objeto de evaluar la vulnerabilidad del gasto público social (en educación y salud) frente a las variables fiscales corrientes y la deuda pública en América Latina en comparación con el resto del mundo en desarrollo. El gasto social es significativamente más bajo en América

Eduardo Lora

2007-01-01

268

Regalías y finanzas públicas en el Departamento del Cesar  

Microsoft Academic Search

Como resultado de las explotaciones de carbón en el Cesar en los últimos años, se han generado importantes recursos de regalías y compensaciones que afectan las finanzas públicas del gobierno departamental. El propósito de este documento es analizar esta relación y proyectar los ingresos y gastos del gobierno departamental para el período 2007 – 2017. Las proyecciones muestran que una

Jaime Bonet Morón

2007-01-01

269

Decoding F508del Misfolding in Cystic Fibrosis  

PubMed Central

The functional deficiency of the cystic fibrosis transmembrane conductance regulator (CFTR), a plasma membrane chloride channel, leads to the development of cystic fibrosis. The deletion of a phenylalanine at residue 508 (F508del) is the most common cause of CFTR misfolding leading to the disease. The F508del misfolding originates in the first nucleotide-binding domain (NBD1), which induces a global conformational change in CFTR through NBD1’s interactions with other domains. Such global misfolding produces a mutant chloride channel that is impaired in exocytic trafficking, peripheral stability, and channel gating. The nature and atomic details of F508del misfolding have been subject to extensive research during the past decade. Current data support a central role for NBD1 in F508del misfolding and rescue. Many cis-acting NBD1 second-site mutations rescue F508del misfolding in the context of full-length CFTR. While some of these mutations appear to specifically counteract the F508del-induced misfolding, others release certain inherent conformational constraints of the human wild-type CFTR. Several small-molecule correctors were recently found to act on key interdomain interfaces of F508del CFTR. Potential rational approaches have been proposed in an attempt to develop highly effective small molecule modulators that improve the cell surface functional expression of F508del CFTR. PMID:24970227

Wang, Xiaodong Robert; Li, Chenglong

2014-01-01

270

CIENCIA, TECNOLOGA, POLTICA Y PLANIFICACIN DEL AGUA Y DE  

E-print Network

de lluvia, reutilización... Adicionalmente al uso del agua y a pesar de que tenemos cada vez unassegunda circular enero 2011 CIENCIA, TECNOLOGÍA, POLÍTICA Y PLANIFICACI�N DEL AGUA Y DE LA ENERGÍA EN LOS REGADÍOS. ASPECTOS SOCIOEC�NOMICOS Y AMBIENTALES. AGRICULTURA, AGUA Y ENERGÍA colaboran MADRID

Escolano, Francisco

271

Los Derechos de los Pacientes del Centro Clnico  

E-print Network

Los Derechos de los Pacientes del Centro Clínico Los Derechos de los Pacientes del Centro Clínico medir las respuestas de los pacientes al tratamiento. Existen procesos que protegen los derechos de paciente que se observen los derechos fundamentales de la dignidad humana. Esta Declaración de Derechos

272

El presidente Obama anuncia nombramiento del doctor Harold Varmus  

Cancer.gov

En los últimos cinco años como director del NCI, y en otras funciones ejercidas durante muchos años, he disfrutado ampliamente cada oportunidad que he tenido de visitar los laboratorios y las oficinas, desde Bethesda hasta Frederick, para conocer en persona a los miembros del personal y compartir mis opiniones sobre temas importantes en torno a la ciencia y al manejo de este gran Instituto.

273

El Instituto Nacional del Cáncer de EE. UU. y la República del Perú firman una Declaración de Intención  

Cancer.gov

El Instituto Nacional del Cáncer y la República del Perú firmaron una declaración de intención para compartir el interés en fomentar la investigación biomédica de oncología, basándose en la colaboración mutua de ambas entidades, así como el objetivo común de educar y capacitar la futura generación de científicos y clínicos en investigación oncológica.

274

Influencia del viento en el comportamiento de búsqueda del alimento en un grupo de aves insectívoras forestales  

Microsoft Academic Search

Carrascal, L.M, 1986. Influencia del viento en el comportamiento de búsqueda del alimento en un grupo de aves insectívoras forestales. Misc. Zool., 10: 277-285. Influence of wind on the foraging behaviour of a guild of arboreal insectivorous birds.- This work was carried away in a subalpine coniferous forest in Central Spain. Wind shifts the birds to the soil and to

L. M. Carrascal

2008-01-01

275

Declaración del Instituto Nacional del Cáncer sobre la aprobación de la vacuna de VPH por la FDA  

Cancer.gov

Hace casi dos décadas que los investigadores del NCI y de otras instituciones comenzaron a investigar las causas fundamentales del cáncer cervical. Esta búsqueda científica resultó en la aprobación de hoy de la vacuna GardasilTM por la Food and Drug Administration.

276

Ttulo del Trabajo: Acerca del estilo de pensamiento en los inicios de la Historia de la Ciencia en la Argentina  

E-print Network

1 Título del Trabajo: Acerca del estilo de pensamiento en los inicios de la Historia de la Ciencia Nacional de Río Cuarto. Facultad de Ciencias Humanas y Facultad de Ciencias Exactas, Físico ­ Químicas y Naturales. Introducción: Una mirada a las actas de las Jornadas de Historias de la Ciencia Argentina (2003

Paris-Sud XI, Université de

277

La guerra del fin del mundo: historia e invencion en una novela historica  

E-print Network

multiplicidad de perspectives Galileo Gall: La ciencia y la revolucion versus el misterio religioso y la realidad sertanera El periodista miope: El testigo ocular y la vocacion del escritor El Baron de Canabrava: El comentario, fanaticos y fracasados 39... para una representacion adecuada de esa "verdad" (traducido de White, 23-24). Pero ". . . [en] la epoca contemporanea el afan critico y cienti- fico extrae a la Historia de la Literature, la convierte en una ciencia, y la entiende desvinculada...

Loeffler, Lisa Bowe

1984-01-01

278

SUSCePTIBILIDaD CaNINa a RaBIa DeSPUÉS De UNa CaMPaÑa De VaCUNaCIÓN eN zoNaS eNDÉMICaS DeL PeRÚ  

Microsoft Academic Search

Objective: To determine the level of immune response after a mass vaccination campaign against rabies in two areas which presented cases of canine rabies in the last years. Materials and methods: A serologic survey was carried out in 101 and 199 dogs located respectively, in the cities of Tambo Grande (Piura) and Juliaca (Puno) and a rabies serum mouse neutralization

Ricardo López I; Albina Díaz O; Edgar Condori C

2007-01-01

279

rea de Actividad Fsica y Salud 445 EVALUACIN ERGONMICA DEL PUPITRE  

E-print Network

del Deporte. Universidad de Extremadura RESUMEN Los alumnos de la Facultad de Ciencias del Deporte de los #12;446 I CONGRESO DE LA ASOCIACIÃ?N ESPAÃ?OLA DE CIENCIAS DEL DEPORTE responsables de compra se partiendo de las quejas de los alumnos de la Facultad de Ciencias del Deporte de la Universidad de

Pantrigo Fernández, Juan José

280

Doctor Harold Varmus, director del NCI: Bienvenidos a Cancer.gov en español  

Cancer.gov

El director del NCI, doctor Harold Varmus, da la bienvenida a los visitantes al sitio web del NCI y habla sobre la complejidad del cáncer, así como de los avances alcanzados gracias a las nuevas herramientas y tecnologías para la investigación del cáncer.

281

Diagnóstico del sector deporte, la recreación y la educación física en Antioquia  

Microsoft Academic Search

En general, podemos resumir este proyecto en tres grandes productos que permiten contextualizar, proponer y desarrollar una política pública a favor del deporte, la educación física y la recreación en Antioquia, que denominaremos en adelante el Sector Deportivo Antioqueño –SDA-. El primero de estos productos es la realización de un diagnóstico del SDA que de cuenta del estado del arte

Ramón Javier Mesa Callejas; Rodrigo Arboleda Sierra; Juan Francisco Gutiérrez Betancur; Mauricio López González

2006-01-01

282

El metabolismo social del País Vasco desde el análisis de flujos materiales  

Microsoft Academic Search

La desvinculación de la mejora del bienestar respecto del uso de los recursos y de la contaminación es esencial para lograr un desarrollo sostenible. Para avanzar en esta dirección es preciso partir del conocimiento del metabolismo de la sociedad. Es decir, debemos analizar en qué medida nuestras sociedades “ingieren” materias primas, que son “metabolizadas” para producir bienes y servicios, y

Iñaki Arto

2009-01-01

283

Universidad Nacional Autnoma de Mxico Instituto de Ciencias del Mar y Limnologa  

E-print Network

Universidad Nacional Autónoma de México Instituto de Ciencias del Mar y Limnología Informe de Instituto de Ciencias del Mar y Limnología Fundamento Legal · Legislación Universitaria · Estatuto General;Informe de actividades 2011 - 2012 Instituto de Ciencias del Mar y Limnología Instituto de Ciencias del

Islas, León

284

Decreto n. 11/10 Il Direttore del Dipartimento di Fisica  

E-print Network

Decreto n. 11/10 Il Direttore del Dipartimento di Fisica Visto il Regolamento relativo al in data 26/11/2007; Vista la delibera del Consiglio del Dipartimento di Fisica del 16/09/2009; Vista la Dipartimento di Fisica per il programma di ricerca dal titolo"Studio di Cosmologia e Fisica Fondamentale dello

Guidoni, Leonardo

285

Decreto n. 10/10 Il Direttore del Dipartimento di Fisica  

E-print Network

Decreto n. 10/10 Il Direttore del Dipartimento di Fisica Visto il Regolamento relativo al in data 26/11/2007; Vista la delibera del Consiglio del Dipartimento di Fisica del 16/09/2009; Vista la Dipartimento di Fisica per il programma di ricerca dal titolo"Studio di Cosmologia e Fisica Fondamentale dello

Guidoni, Leonardo

286

Current Work in Laser Cleaning of the Porta del Paradiso  

NASA Astrophysics Data System (ADS)

This paper summarises the conservation of the Porta del Paradiso, currently underway. It briefly illustrates the two cleaning methods employed and the reasons leading to continue the cleaning of the perimeter panels with laser ablation, describing the various working phases.

Agnoletti, S.; Brini, A.; Nicolai, L.

287

Modular cell biology: retroactivity and insulation Domitilla Del Vecchio1,  

E-print Network

Modular cell biology: retroactivity and insulation Domitilla Del Vecchio1, *, Alexander J Ninfa2 a remarkable insulation property, due to the fast timescales of the phosphorylation and dephosphorylation: computational methods; metabolic and regulatory networks Keywords: feedback; insulation; modularity; singular

Sontag, Eduardo

288

La Revolucin del Shale Gas Profesor: Hugh Rudnick  

E-print Network

La Revolución del Shale Gas Mayo 2011 Profesor: Hugh Rudnick Profesional Externo: Verónica Cortés........................................................................................................................................ 6 ¿Qué es el Shale Gas...................................................................................................................................... 7 Shale Gas

Rudnick, Hugh

289

Particle Methods for Filtering & Uncertainty Propagations P. Del Moral  

E-print Network

, ... · Physics (sensors : pressure/temperature/...). · Finance (assets, portfolios,...). · Statistics (real dataParticle Methods for Filtering & Uncertainty Propagations P. Del Moral INRIA team ALEA, INRIA, pressure/temperature/diffusion coefficients,...). · Finance (assets, portfolios, volatilities, default

Del Moral , Pierre

290

Difusión de resultados iniciales del Estudio del Tamoxifeno y del Raloxifeno (STAR): el fármaco para el tratamiento de la osteoporosis, raloxifeno, es tan efectivo como el Tamoxifeno en la prevención de cáncer de seno invasor  

Cancer.gov

Los resultados iniciales del Estudio del Tamoxifeno y del Raloxifeno, STAR, demuestran que el fármaco raloxifeno, actualmente utilizado para prevenir y tratar la osteoporosis en mujeres posmenopáusicas, funciona tan bien como el tamoxifeno para reducir el riesgo de cáncer de seno entre las mujeres posmenopáusicas que tienen riesgo elevado de padecer la enfermedad. Preguntas y respuestas

291

UNIVERSIDAD NACIONAL AUTNOMA DE MXICO Datos del plan de estudio  

E-print Network

Síntesis o descripción breve: Se atienden las vertientes propias de las ciencias aplicadas al deporte para · La Actividad Física y el Deporte · Nutrición en el Deporte · Psicología del Adolescente Módulo II Entrenamiento Deportivo · Psicología del Deporte · Formación Docente · Recreación en el Deporte · Taller de

Islas, León

292

Calidad del aire interior y salud en las viviendas  

E-print Network

Calidad del aire interior y salud en las viviendas temporales de FEMA A los residentes de los que usted pueda tener sobre la calidad del aire y el formaldehído en los tráileres de FEMA. Usted pequeños, como los tráileres de FEMA, los venenos para matar insectos también pueden irritar l a nariz o la

293

Jornada d'ensenyament i s del valenci als  

E-print Network

Jornada d'ensenyament i ús del valencià als centres educatius 2014 Intercanvi d'experiències d'educació plurilingüe. ALACANT, 5 de juny de 2014 Lloc de realització: Universitat d'Alacant #12;Jornada d'ensenyament i ús del valencià als centres educatius 2014 Intercanvi d'experiències d'educació plurilingüe En un

Escolano, Francisco

294

Design, aerodynamics and autonomy of the DelFly  

Microsoft Academic Search

One of the major challenges in robotics is to develop a fly-like robot that can autonomously fly around in unknown environments. In this paper, we discuss the current state of the DelFly project, in which we follow a top-down approach to ever smaller and more autonomous ornithopters. The presented findings concerning the design, aerodynamics and autonomy of the DelFly illustrate

G C H E de Croon; M A Groen; C De Wagter; B Remes; R Ruijsink; B W van Oudheusden

2012-01-01

295

Miami: Meca del exilio cubano y escenario medido aunque efervescente  

E-print Network

Agüero, Raúl Duran y David Ferrer, logrando niveles intertextuales muy ricos pues cada movimiento, cada signo básico, cada inflexión verbal, encontró correspondencias afínes en la comunidad cubana del exilio para la que se representó, fuera de que... del autor como Jesús, bajo la dirección de Rolando Moreno, estrenada en 1994. A esta última obra se le dio un tratamiento musical que no desentonó con el tema de la misma y reafirmó el gusto ya estudiado en otra ocasión de esta comunidad por el...

Rizk, Beatriz J.

2000-10-01

296

Extreme Environments in Tierra del Fuego, Argentina  

NASA Astrophysics Data System (ADS)

The upper timberline of the Andes Cordillera on the island of Tierra del Fuego at the tip of South America is an environment subject to extreme conditions. In order to further understand this environment, ecosystem parameters were measured within two transects of the Andes at Glaciar Martial and Cerro Guanaco. The measurements included pH, soil temperature, soil moisture, nitrogen, sodium and potassium concentration, chlorophyll absorbance, and irradiance in the ultraviolet range (200-400 nm). These data comprise a survey that serves as a baseline for an intensive research program. Chlorophyll concentration and soil data were within the range of our observations at several other sites, from Lapataia Bay on the southwestern boundary with Chile, through the eastern end of Lake Fagnano. However, unusual levels of solar irradiance were found in the open sites of both transects while those in the forest exhibited lower UV values, suggesting strong absorption and/or reflection by the forest canopy. High levels of UV radiation damage important biomolecules and may be partially responsible for the presence of life forms such as the krummholz belt in the upper timberline. These UV values may be due to the effects of global ozone depletion and the ozone hole. The low temperatures, strong winds, snow and ice-covered soil and especially the exposure to UV radiation make this area an extreme environment for life.

Schultz, C.; D'Antoni, H.; Burgess, S.; Zamora, J.; Skiles, J.

2007-12-01

297

Rompimiento de la Simetria Electrodebil y la Fisica del Higgs: Conceptos Basicos  

E-print Network

Presentamos una introduccion a los conceptos basicos del rompimiento de la simetria electrodebil y la fisica del Higgs dentro del Modelo Estandar y sus extensiones supersimetricas. Se presenta tambien una breve perspectiva general de mecanismos alternativos del rompimiento de la simetria. Ademas de las bases teoricas, se discute el estado actual de la fisica experimental del Higgs y sus implicaciones para futuros experimentos en el LHC y en colisionadores lineales e+e-.

M. Gomez-Bock; M. Mondragon; M. Muhlleitner; R. Noriega-Papaqui; I. Pedraza; M. Spira; P. M. Zerwas

2005-09-08

298

Assicurativo | Bancario | Finanziario Allianz SpA ai primi posti del mercato italiano delle assicurazioni e dei servizi finanziari e fa parte del  

E-print Network

italiano delle assicurazioni e dei servizi finanziari e fa parte del Gruppo Allianz SE, il leader confermata ai vertici del mercato italiano in termini di solidità patri- moniale con il solvency ratio e i

Schettini, Raimondo

299

XI Muestra Nacional de Teatro Peruano y I Encuentro Interregional de Teatro Peruano del Movimiento de Teatro Independiente del Perú  

E-print Network

considerar que Cusco es un "pueblo testimonio" del choque de dos culturas de alta civilización y nombrado por la ONU Patrimonio Mundial de la historia de la humanidad. MOTIN-CUSCO amplió la programación para paralelamente realizar la I Muestra...

Ferguson Acosta, Dennis

1993-10-01

300

Memorias del Segundo Simposio Internacional Sobre Polticas, Planificacin y Economa de los Programas de Proteccin Contra Incendios Forestales: Una Visin Global Memorias del Segundo Simposio Internacional Sobre Polticas, Planificacin y Economa de los Progra  

E-print Network

economía agrícola (Department of Agricultural Economics), 51 Campus Drive, University of Saskatchewan-Cabán, Hesseln Introducción El número creciente de incendios en zonas silvestres cada verano ha dado lugar

Standiford, Richard B.

301

Línea de base del Proyecto de producción ecológica, comercialización y asociatividad de las mujeres en el medio rural: Manual del sistema de monitoreo y seguimiento  

Microsoft Academic Search

El Sistema de monitoreo y seguimiento ha sido elaborado especialmente para la organización En las Huellas del Banco Grameen-Loja, cuyo propósito es facilitar el acceso a servicios financieros y técnicos eficientes y sostenibles para mujeres microempresarias del sur ecuatoriano. El manual fue diseñado como un instrumento que sirva de guía para que la dirección ejecutiva y la coordinación del Proyecto

Carlos Palán Tamayo

2009-01-01

302

LAS CLASES SE IMPARTIRN EN EL AULA 057, PLANTA BAJA DEL EDIFICIO DEPARTAMENTAL, CAMPUS DE 2013 Horarios Mster en Gestin del Transporte y la Movilidad -Primer cuatrimestre  

E-print Network

VICÁLVARO 2013 Horarios Máster en Gestión del Transporte y la Movilidad - Primer cuatrimestre SEPTIEMBRE 16 sistemas de transporte Infraestructuras de la movilidad Jueves 19 Organización y financiación del transp transporte Infraestructuras de la movilidad Jueves 26 Organización y financiación del transp. Economía

Rey Juan Carlos, Universidad

303

Poich il28 Ottobre prevista alla stessa ora l'Assemblea Generale del Personale nell'Androne Principale del Policlinico Umberto I  

E-print Network

'Androne Principale del Policlinico Umberto I: E' convocata la Riunione di tutti i componenti della R.S.U. per Policlinico Umberto I; 5) Situazione Personale del Policlinico Umberto I; 6) Progetti obiettivi: attività in regime di straordinario (Policlinico Umberto I); 7) Ipotesi di dotazione organica per il personale del

Guidoni, Leonardo

304

XI INTI International Conference La Plata 2012 Equipo TAG Territorios Posibles UNLP-CONICET y Universidades asociadas del GDRI  

E-print Network

- CONICET EL CRECIMIENTO URBANO Y SU RELACI�N CON LOS PROCESOS TERRITORIALES EN LA "RNU LAS CARTAS-patagónica, tienen un gran atractivo mundial la demanda de tierras en zonas naturales excepcionales o privilegiadas elementos naturales que incluyen las tierras o territorios en venta. En escalas menores, los cambios que se

Paris-Sud XI, Université de

305

Modelo semi-empírico de protuberancia solar a partir del diagnóstico de densidades  

NASA Astrophysics Data System (ADS)

A partir de la observación del espectro del quintuplete de C III alrededor de 1175 Å, se ha realizado el diagnóstico de la densidad y presión electrónica, basado en el cálculo del cociente de las intensidades observadas. Una vez establecida la densidad electrónica, y con el cálculo de las velocidades Doppler, hemos investigado el flujo de masa en la protuberancia en función de la temperatura. Estableciendo como hipótesis la conservación del número de partículas que ingresan y salen del cuerpo de la protuberancia, se investiga la variación del área de un tubo de flujo semi-empírico en función de la temperatura. A partir de dicho diagnóstico, se examina el comportamiento del radio del tubo magnético en función de la temperatura, los que dan cuenta de la abertura de las líneas de campo magnético que confinan el plasma y de la divergencia del campo magnético en diferentes alturas de la atmósfera solar.

Cirigliano, D.; Vial, J. C.; Rovira, M.

306

RISULTATI VALUTAZIONE TITOLI DEL CONCORSO PER L'ASSEGNAZIONE DI N.1 ASSEGNO DI RICERCA PROG. DI RICERCA N. 11.05 BANDITO CON D.R. N.2285 DEL 3.6.2013  

E-print Network

, piazza Umberto I, 1, Bari. Visto l'art. 8 del D.R. n. 2285 DEL 3.6.2013, che prevede l, piazza Umberto I, 1, Bari. Visto l'art. 8 del D.R. n. 2285 DEL 3.6.2013, che prevede l, piazza Umberto I, 1, Bari. #12;3 Visto l'art. 8 del D.R. n. 2285 DEL 3.6.2013, che prevede l

Malerba, Donato

307

Field measurements of del13C in ecosystem respiration  

NASA Astrophysics Data System (ADS)

Stable carbon isotope del13C-measurements are extensively used to study ecological and biogeochemical processes in ecosystems. Above terrestrial ecosystems, atmospheric del13C can vary largely due to photosynthetic fractionation. Photosynthetic processes prefer the uptake of the lighter isotope 12C (in CO2), thereby enriching the atmosphere in 13C and depleting the ecosystem carbon. At night, when ecosystem respiratory fluxes are dominant, 13C-depleted CO2 is respired and thereby depletes the atmospheric del13C-content. Different ecosystems and different parts of one ecosystem (type of plant, leaves, and roots) fractionate and respire with a different del13C-ratio signature. By determining the del13C-signature of ecosystem respiration in temporal and spatial scale, an analysis can be made of the composition of respiratory sources of the ecosystem. A field study at a dry cropland after harvest (province of Viterbo, Lazio, Italy) was performed in the summer of 2013. A FTIR (Fourier Transform Infrared Spectrometer) was set up to continuously measure CO2-, CH4-, N2O-, CO- and del13C-concentrations. The FTIR was connected to 2 different flux measurements systems: a Flux Gradient system (sampling every half hour at 1.3m and 4.2m) and 2 flux chambers (measured every hour), providing a continuous data set of the biosphere-atmosphere gas fluxes and of the gas concentrations at different heights. Keeling plot intercept values of respiratory CO2, measured by the Flux Gradient system at night, were determined to be between -25‰ and -20‰. Keeling plot intercept values of respiratory CO2, measured by the flux chamber system, varied between -24‰ and -29‰, and showed a clear diurnal pattern, suggesting different (dominant) respiratory processes between day and night.

van Asperen, Hella; Sabbatini, Simone; Nicolini, Giacomo; Warneke, Thorsten; Papale, Dario; Notholt, Justus

2014-05-01

308

La nostalgia del paraíso en Un hogar sólido  

E-print Network

de la túnica de un ángel" (26); para Eva, una "centella que se hunde en el mar negro" (27); para Clemente "una partícula de la piedra de San Pedro" (26) o "la lluvia sobre el agua" (27); para Gertrudis, "leño en llamas" (27); para Jesusita, "el... como en otras tradiciones religiosas, este sitio está íntegramente ligado a las aguas o ríos primordiales (Partin 184). A modo de ejemplo, citamos del libro del Génesis de la Biblia, el cual también evoca la imagen de la intersección de cuatro líneas...

Anderson, Robert K.

2001-04-01

309

I Taller Internacional del Nuevo Teatro (Cuba 1983)  

E-print Network

-tease lo ejecutan y componen hombres, el acto de la cuerda floja se hace por debajo de la cuerda, al cantante popular no se le entiende la letra, etc. Esta contradicción del sentido en la formación de las imágenes viene a realzar la diferencia que existe... relación entre ellos. "Esto debe crear una reflexión del trabajo y en la medida de lo posible debe llevarse al campo de la teoría. Este taller se desarrolla en este espíritu de investigación cuyos resultados vamos a ver. No con el 78 LATIN AMERICAN...

Rizk, Beatriz J.

1983-04-01

310

La consagración del mito en la epopeya mexicana: La Malinche de Celestino Gorostiza  

E-print Network

FALL 1985 33 La consagración del mito en la epopeya mexicana: La Malinche de Celestino Gorostiza Isis Quinteros Los estudiosos del drama como género literario han señalado en varias ocasiones la estrecha relación que históricamente ha vinculado...

Quinteros, Isis

1985-10-01

311

Denaturazione termica e meccanica del DNA : teoria a confronto con gli  

E-print Network

Capitolo 3 Denaturazione termica e meccanica del DNA : teoria a confronto con gli esperimenti. DENATURAZIONE TERMICA E MECCANICA DEL DNA : TEORIA A CONFRONTO CON GLI ESPERIMENTI della transizione DNA B-DNA d

Cocco, Simona

312

33 CFR 162.35 - Channel of Christina River, Del.; navigation.  

Code of Federal Regulations, 2014 CFR

...Navigable Waters 2 2014-07-01 2014-07-01 false Channel of Christina River, Del.; navigation. 162.35 Section...SAFETY INLAND WATERWAYS NAVIGATION REGULATIONS § 162.35 Channel of Christina River, Del.; navigation. (a) That...

2014-07-01

313

El té y la prevención del cáncer: Solidez y límites de la evidencia científica  

Cancer.gov

Hoja informativa que resume los resultados de estudios realizados sobre el té y la prevención del cáncer. Incluye información sobre los ingredientes del té y las consideraciones de seguridad sobre el consumo de esta bebida.

314

El sexagésimo aniversario del Teatro Experimental de la Universidad de Chile  

E-print Network

SPRING 2001 189 El sexagésimo aniversario del Teatro Experimental de la Universidad de Chile Domingo Piga Desde antes de la primera función y de la creación del Teatro Experimental, cuando sólo nos movía la pasión por el teatro, nosotros, los...

Piga, Domingo

2001-04-01

315

El doctor Varmus dirigirá una institución "inigualable", afirma el director del NCI, doctor John Niederhuber  

Cancer.gov

En un mensaje dirigido al personal del Instituto Nacional del Cáncer (NCI) y a quienes se interesan por la oncología, el doctor John Niederhuber, director del NCI, aplaude el nombramiento de Harold Varmus y afirma que esta designación le "dará al NCI un liderazgo fuerte no solo en la institución sino mas allá de ella, así como una voz muy respetada en el Congreso, que abogue por los recursos que son tan necesarios para sostener la misión del Instituto.

316

Aspectos Económicos del Gobierno de Carlos Lleras Restrepo. (Colombia, 1966-1970)  

Microsoft Academic Search

El gobierno de Carlos Lleras Restrepo se destaca en la historia de Colombia por haber introducido una reforma institucional de amplias proporciones que fortaleció las bases del Estado intervencionista. Este hecho, sumado a una concepción estructuralista sobre el manejo monetario y cambiario, permitió un evidente despegue del sector exportador no tradicional y un crecimiento del PIB sin antecedentes en la

Pascual Amézquita Zárate

2010-01-01

317

Se pone en marcha el Programa de Investigación Oncológica Comunitaria (NCORP) del NCI  

Cancer.gov

El Instituto Nacional del Cáncer (NCI) ha otorgado 53 subvenciones nuevas de 5 años a investigadores de todo el país para realizar estudios clínicos multicéntricos e investigaciones sobre la prestación de cuidados oncológicos en sus comunidades. Las subvenciones se están otorgando dentro del Programa de Investigación Oncológica Comunitaria (Community Oncology Research Program, NCORP) del NCI.

318

rea de Biomecnica del Deporte Rendimiento Deportivo 209 DESARROLLO DE UNA "TOOLBOX" DE TRATAMIENTO  

E-print Network

Área de Biomecánica del Deporte ­ Rendimiento Deportivo 209 DESARROLLO DE UNA "TOOLBOX" DE_mail: kgiannik@unex.es Pantrigo, J.J. Vara Gazapo, A. Galapero, L. Facultad de Ciencias del Deporte. Universidad DE CIENCIAS DEL DEPORTE "corrompe" la señal obtenida. Así que, el procesamiento digital de señales se

Pantrigo Fernández, Juan José

319

Pautas para el monitoreo y la evaluación de proyectos del Programa de Empresariado Social  

Microsoft Academic Search

El objetivo de este documento es definir y tratar un conjunto mínimo de indicadores básicos de monitoreo y evaluación de proyectos que se deben recoger en todos o casi todos los proyectos aprobados en el marco del Programa de Empresariado Social (PES) del BID. El documento está dirigido al personal del BID y de instituciones homólogas que se dedican a

Glenn D. Westley

2003-01-01

320

Proyección del Fondo de Pensiones y Análisis de su Efecto en el Mercado Financiero  

Microsoft Academic Search

Este trabajo se compone de dos partes. La primera describe un modelo de proyección (contable en lo básico) del tamaño del Fondo de Pensiones chileno para las próximas dos décadas, y discute una proyección específica.La segunda parte discute el efecto probable que el crecimiento del Fondo tendría sobre el mercado financiero nacional. En particular, la discusión está orientada por la

Felipe Zurita

2005-01-01

321

Mercado interbancario colombiano y manejo de liquidez del Banco de la República  

Microsoft Academic Search

El documento tiene como objetivo describir algunos de los elementos fundamentales del mercado interbancario colombiano y del manejo de liquidez por parte del Banco de la República (BR). El documento explica las diferencias entre las principales operaciones en este mercado y describe los mecanismos a través de los cuales el BR suministra liquidez o recoge excesos de la misma en

Pamela cardozo Ortiz; carlos A. Huertas Campos; Julián A. Parra POlanía; Lina V. Patiño ECheverri

322

Situazione del Gufo reale in Svizzera In Svizzera il Gufo reale Bubo bubo era origina-  

E-print Network

Situazione del Gufo reale in Svizzera In Svizzera il Gufo reale Bubo bubo era origina- riamente Conservation Biology 2 Ficedula N. 40 DISPERSIONE DEI GIOVANI E MORTALITÃ? DEL GUFO REALE BUBO BUBO IN SVIZZERA Un'immagine emblematica per la conservazione del Gufo reale Bubo bubo. Le linee elettriche

Richner, Heinz

323

Gasto publico en educacion y distribucion del ingreso en el Peru  

Microsoft Academic Search

El estudio evalúa los efectos que el gasto público en educación ha tenido sobre la distribución del ingreso en el Perú. Las transferencias desde el presupuesto público son analizados revisando el destino del gasto en educación por estratos socioeconómicos, y su impacto de corto plazo en términos de la mejora del ingreso familiar y la modificación de la estructura distributiva.

José Rodríguez

1992-01-01

324

¿Gastar más o gastar mejor?: La eficiencia del gasto público en América Central y República Dominicana  

Microsoft Academic Search

El presente estudio realiza un análisis comparativo regional acerca de la eficiencia del gasto público tanto a nivel agregado como a nivel del gasto social, el gasto en educación y el gasto en salud. El trabajo busca dar respuesta a una pregunta por demás relevante para los países en desarrollo en general, a saber, si para mejorar el desempeño del

Roberto Machado

2006-01-01

325

Aportació al coneixement florístic de les Guilleries i del Collsacabra (Catalunya Oriental),II  

Microsoft Academic Search

Presentem noves dades corològiques per a la flora vascular dels massissos de les Guilleries i del Collsacabra. En total, tractem 25 tàxons que podem dividir en cinc grups: 1.- nous per a les Guilleries (Peucedanum officinale L., Senecio adonidifolius Loisel., etc.); 2.- nous pel Collsacabra (Carex liparocarpos Gaudin, Seseli tortuosum L., etc.); 3.- nous per un ampli sector del nord-est

Aaron Pérez-Haase; Efrem Batriu; Arnau Mercadé López

2008-01-01

326

1 Introduzione alla Correlazione Elettronica 6 2 Teoria del Funzionale della Densit a 19  

E-print Network

Indice 1 Introduzione alla Correlazione Elettronica 6 2 Teoria del Funzionale della Densit#18;a 19 Teoria del Funzionale della Densit#18;a (DFT) [3] [4]. Tutte queste approssimazioni richiedono metodi DFT. Inoltre il QMC #18;e stato sovente usato per investigare le basi stesse della teoria del

Botti, Silvana

327

DEPARTAMENT DE FSICA, ENGINYERIA DE SISTEMES I TEORIA DEL SENYAL SECRETARIA  

E-print Network

Inici DEPARTAMENT DE FÍSICA, ENGINYERIA DE SISTEMES I TEORIA DEL SENYAL CONTACTE: HORARI DE SECRETARIA: Dept. de Física, Enginyeria de Sistemes i Teoria del Senyal Universitat d'Alacant Edifici'agost tancat NOTÍCIES I ESDEVENIMENTS Departament de Física, Enginyeria de Sistemes i Teoria del Senyal #12

Escolano, Francisco

328

BOLETN OFICIAL DEL ESTADO Nm. 279 Jueves 21 de noviembre de 2013 Sec. III. Pg. 92894  

E-print Network

ayudas para la formación de profesorado universitario de los subprogramas de Formación y de Movilidad Estatal de Movilidad. En cumplimiento de dichos objetivos, el Ministerio de Educación, Cultura y Deporte formación y movilidad del Programa Estatal de Promoción del Talento y su Empleabilidad, del Plan Estatal de

Rey Juan Carlos, Universidad

329

INICIO POLTICA ECONOMA MUNDO ESTADOS CAPITAL SOCIEDAD Y JUSTICIA CIENCIAS CULTURA ESPECTCULOS DEPORTES Noticias del da  

E-print Network

INICIO POLÍTICA ECONOMÍA MUNDO ESTADOS CAPITAL SOCIEDAD Y JUSTICIA CIENCIAS CULTURA ESPECTÁCULOS DEPORTES Noticias del día No hay noticias publicadas. Ciencias No hay noticias publicadas. BUSCAR Buscar en, del Instituto de Ciencias del Mar y Limnología de la UNAM La Jornada en línea Publicado: 24/01/2012 12

Islas, León

330

Conozca cuáles son las opciones de atención del cáncer en su comunidad  

Cancer.gov

Este artículo hace una presentación general de las funciones del programa de centros oncológicos designados por el NCI y del programa de investigación oncológica comunitaria del NCI en Estados Unidos, los cuales son una fuente importante de atención para pacientes con cáncer.

331

UNIVERSIDAD NACIONAL AUTNOMA DE MXICO Datos del plan de estudio  

E-print Network

Actividad Física y el Deporte Dirigido a: Comunidad Universitaria y Público General Síntesis o descripción. Significado del deporte vs. agresión Metodología: 1. Desarrollo de las capacidades biomotoras 2. Etapa de

Islas, León

332

UNIVERSIDAD NACIONAL AUTNOMA DE MXICO Datos del plan de estudio  

E-print Network

· Nutrición · Principios psicológicos del deportista · Recreación y deporte · Introducción al entrenamiento deporte · Plan de entrenamiento · Word Módulo III · Control médico deportivo · Preparación mental

Islas, León

333

UNIVERSIDAD NACIONAL AUTNOMA DE MXICO Datos del plan de estudio  

E-print Network

· Sistemas neuromusculares y endócrinos en el ejercicio · Motivación y emoción en el deporte · Trabajo con · Sistemas en el organismo · Actitud y deporte · Caracterización del entrenamiento deportivo · Aplicaciones

Islas, León

334

La Medicina del Lavoro e l'impact factor.  

PubMed

Lo spunto per la preparazione di questo editoriale è venuto dal rilascio, lo scorso 30 luglio, dei valori di impact factor 2013 da parte del Journal of Citation Records. L'impact factor è un parametro bibliometrico che qualifica il prestigio di una rivista.... PMID:25431979

Fustinoni, Silvia

2014-01-01

335

I CONGRESO INTERNACIONAL DEL AGUA .... por la vida  

E-print Network

Guayana, Estado Bolívar, Venezuela. Mesa # 7: Reducir los riesgos y hacer frente a la incertidumbre la naturaleza transversal y compleja del riesgo y el agua. 2. Riesgo y agua en Venezuela, un monitoreo poco consolidado para una exposición territorial a la amenaza alta. (3) Venezuela tiene

Paris-Sud XI, Université de

336

EL IMPACTO SOCIAL DEL SECTOR BANCARIO EN COLOMBIA, 1993 - 2002  

Microsoft Academic Search

Este documento estudia el impacto del sector bancario sobre variables sociales en Colombia, y busca identificar cómo la diferencia en el desarrollo de las instituciones bancarias a nivel municipal influye sobre la prosperidad económica y social de hogares de bajos recursos y de las empresas en esas localidades. El estudio busca identificar empíricamente cómo la bancarización o el acceso a

Juan Carlos Echeverry Garzón; Ángela María Fonseca Galvis

2006-01-01

337

Eficiencia, Equidad y Reestructuración Sectorial del Gasto Público Social  

Microsoft Academic Search

Es muy arriesgado suponer que la distribución sectorial del gasto público social corriente en los países en desarrollo es socialmente óptima. No obstante, sería también insensato pretender alterar completamente –y en el corto plazo- su distribución intersectorial con base en un análisis normativo. A partir de un statu quo subóptimo y siguiendo la idea básica de la teoría de la

Carlos Eduardo Vélez E

1997-01-01

338

LA NATURALESA DEL VALOR O EL VALOR DE LA NATURALESA  

E-print Network

-1790), David Ricardo (1772-1823) i Karl Marx (1818-1883), en fan la teoria del valor. Un assumpte de curiosa, a diferència de Karl Marx, accepta la dualitat entre valor d'ús i valor de canvi. Així, d'entrada, matisa el

Oro, Daniel

339

Visualization Queries Nicholas Del Rio and Paulo Pinheiro da Silva  

E-print Network

Visualization Queries Nicholas Del Rio and Paulo Pinheiro da Silva The University of Texas at El the notion of a query that describes a visualization request in terms of a universe of concepts, which on these concepts, users may be able to request for what properties they want to see in their visualizations (i

Ward, Karen

340

Introducción al estudio de la incidencia del gasto público  

Microsoft Academic Search

Se estudia la incidencia de los ingresos y gastos públicos en las diferentes regiones españolas. En lo que se refiere al gasto se utiliza dos enfoques de incidencia, según la fuente de datos empleada. Además se ofrece una segunda resultante de la imputación del gasto en presupuestos de nuestras Administraciones públicas entre las distintas regiones

Laura de Pablos Escobar

1998-01-01

341

Carbon sink forestali: quale governance del mercato dei crediti?  

E-print Network

11/10/2008 1 Carbon sink forestali: quale governance del mercato dei crediti? Davide Pettenella"" ((CarbonCarbon cheatingcheating)) "For its practical effect, telling people to plant trees is like telling carbon offsets ensure development benefits? Overseas Development Institute, Forestry Briefing 13 AA.. l

Pettenella, Davide

342

Control del dolor: Apoyo para las personas con cáncer  

Cancer.gov

Contiene información sobre las medicinas contra el dolor para pacientes con cáncer, los planes para controlarlo, cómo hablar con su equipo de atención médica sobre el dolor que usted siente y qué hacer para controlar los efectos físicos y emocionales del mismo.

343

Tratamiento del paludismo pediátrico: Papel de las intervenciones nutricionales  

Microsoft Academic Search

ResumenEl paludismo es una causa primordial de morbilidad y mortalidad en niños, particularmente en África subsahariana. Aunque se ha logrado un progreso considerable en el tratamiento del paludismo pediátrico con el tratamiento de combinación basado en la artemisinina, siguen existiendo numerosos obstáculos que se oponen a la puesta en práctica efectiva de estas nuevas opciones terapéuticas sumamente eficaces. Análogamente, si

Akoto Kwame Osei; Davidson H. Hamer

2008-01-01

344

Fundamentos del Anlisis Econmico Universidad de Alicante TEORIA ECO MICA  

E-print Network

Fundamentos del Análisis Económico Universidad de Alicante TEORIA ECO �MICA Curso 2010/11 Iñigo:30-14:30 Tutorías: Lunes: 14:30-16:30; Jueves: 9:30-12:30 Página de la asignatura: http://merlin.fae.ua.es/iturbe/Teoria

Escolano, Francisco

345

Dispense di Elementi di Teoria degli insiemi Giulio Del Corso  

E-print Network

GDC 1 Dispense di Elementi di Teoria degli insiemi (ETI) Giulio Del Corso Attenzione: Questi Teoria intuitiva ed introduttiva 7 Cardinalità 10 Teoria assiomatica ZFC 14 Aritmetica di Peano 16 Teoria delle classi 17 Buoni ordini 20 Ordinali 26 Cardinali #12;GDC 3 Teoria di Elementi di Teoria degli

Di Nasso, Mauro

346

VERBALE DEL COMITATO ETICO GIOVEDI' 19 FEBBRAIO 2009  

E-print Network

2009 3. Esame del progetto "Effects of an antioxidant-supplemented snack on oxidative stress: a pla "Effects of an antioxidant-supplemented snack on oxidative stress: a pla- cebo-controlled double titolo "Effects of an antioxidant-supplemented snack on oxidative stress: a placebo-controlled double

De Cindio, Fiorella

347

IUS Y LEX: LA NATURALEZA Y LÓGICA DEL PODER HUMANO  

Microsoft Academic Search

El presente trabajo fue expuesto por primera vez en el año de 1999, en una universidad local de la Paz, Baja California Sur. Se pretendía con éste, abrir brecha en la investigación pura, dentro del ámbito de las Ciencias Sociales, e ir despertando poco a poco el interés por las ciencias aplicadas en este campo. Como ya es moneda común

Héctor Murillo Aguilar

2008-01-01

348

La fisica del Novecento e Majorana Riccardo Barbieri  

E-print Network

La fisica del Novecento e Majorana Riccardo Barbieri Scuola Normale Superiore and INFN, Piazza dei'attivita' di Majorana in relazione con la fisica dell'intero Novecento, cercando di proiettare questa relazione nel futuro: il ruolo delle simmetrie nella fisica delle interazioni cosiddette fondamentali. #12

Abbondandolo, Alberto

349

La coordinación entre niveles asistenciales: del discurso al proyecto transformador  

Microsoft Academic Search

La falta de coordinación entre los diferentes niveles asistenciales, y particularmente entre atención primaria y hospitales ha suscitado miles de artículos, debates técnicos y polémicas encendidas, pero escasos avances prácticos. La persistencia del problema se debe indudablemente a su complejidad, porque la existencia de talento y experiencia generosamente distribuido en el sistema sanitario en teoría deberían haber provocado el desarrollo

Raimon Belenes

2009-01-01

350

The Delaware Model: A Systems Approach (Del Mod System).  

ERIC Educational Resources Information Center

This monograph presents a description, along with the purposes, of the Del Mod System. It is described as a system concerned with inducing changes in the existing systems in the area of science education. The investment of time and funds (a National Science Foundation-funded project) is devoted to an alteration of the behavior patterns of…

Purnell, Charlotte H.

351

Del Mod: A State-Wide System for School Improvement.  

ERIC Educational Resources Information Center

This is a retrospective account of the Del Mod System, a statewide project to improve science and mathematics education in the elementary and secondary schools of Delaware. The project functioned from 1970-76 under the auspices of a committee including the presidents of institutions of higher education, the state superintendent of public…

Neale, Daniel C.

352

How Can Psychology Help Artificial Intelligence Alvaro del Val  

E-print Network

This paper discusses the relationship between Artificial Intelligence (AI) and Psychology. As an AIHow Can Psychology Help Artificial Intelligence Alvaro del Val Departamento de Ingenier'ia Inform Artificial intelligence is interdisciplinary in its very nature, and has from its birth benefited by input

del Val, Alvaro

353

Formalizaci on del razonamiento ecuacional en una l ogica computacional  

E-print Network

Formalizaci#19;on del razonamiento ecuacional en una l#19;ogica computacional J.L. Ruiz, J formalizaci#19;on en una l#19;ogica computacional (la l#19;ogica de ACL2), de diversas propiedades de la l#19 propiedades de sistemas de computaci#19;on, la denominamos l#19;ogica computacional. La principal ventaja que

Reina, José Luis Ruiz

354

En este artículo se presenta un estudio de la calidad del aire en la ciudad de Rosario, Argentina. Se detallan las concentraciones de Monóxido de Carbono, Dióxido de Azufre y Oxidos de Nitrógeno que se obtuvieron mediante la operación de cuatro  

Microsoft Academic Search

Los resultados reflejan la existencia de bajas concentraciones de estos conta- minantes en zonas suburbanas y altas concentraciones en zonas cercanas al centro comercial, motivado por una mayor circulación de automotores en estas últimas. También muestran una tendencia creciente para los Oxidos de Nitrógeno en 1995 respecto a 1994, acompañado por un crecimiento en la cantidad de Monóxido de Carbono.

Daniel A. Andrés; Eduardo J. Ferrero; E. Zeballos

355

Esercitazione del 28 febbraio 2003 Progetto del sistema di controllo di vibrazione per la sospensione di un'automobile  

E-print Network

sospensione di un'automobile (sospensione attiva) Il sistema raffigurato rappresenta lo schema semplificato pneumatico-ammortizzatore-telaio di un'automobile. Il sistema è caratterizzato dalla massa equivalente M dell'automobile esercitare sulla ruota e sul telaio dell'automobile e come azione disturbante d il profilo dell'asperità del

Monaco, Salvatore

356

Esercitazione del 14 febbraio 2003 Progetto del sistema di controllo di vibrazione per la sospensione di un'automobile  

E-print Network

sospensione di un'automobile (sospensione attiva) Il sistema raffigurato rappresenta lo schema semplificato pneumatico-ammortizzatore-telaio di un'automobile. Il sistema è caratterizzato dalla massa equivalente M dell'automobile esercitare sulla ruota e sul telaio dell'automobile e come azione disturbante d il profilo dell'asperità del

Monaco, Salvatore

357

Esercitazione del 21 marzo 2003 Progetto del sistema di controllo di vibrazione per la sospensione di un'automobile  

E-print Network

di un'automobile (sospensione attiva) Il sistema raffigurato rappresenta lo schema semplificato pneumatico-ammortizzatore-telaio di un'automobile. Il sistema è caratterizzato dalla massa equivalente M dell'automobile esercitare sulla ruota e sul telaio dell'automobile e come azione disturbante d il profilo dell'asperità del

Monaco, Salvatore

358

Esercitazione del 7 marzo 2003 Progetto del sistema di controllo di vibrazione per la sospensione di un'automobile  

E-print Network

di un'automobile (sospensione attiva) Il sistema raffigurato rappresenta lo schema semplificato pneumatico-ammortizzatore-telaio di un'automobile. Il sistema è caratterizzato dalla massa equivalente M dell'automobile esercitare sulla ruota e sul telaio dell'automobile e come azione disturbante d il profilo dell'asperità del

Monaco, Salvatore

359

Estrategia innovadora enfocada en parejas del mismo sexo para disminuir la infección del VIH en hombres Latinos  

PubMed Central

Resumen El VIH es un problema de salud importante dentro de la comunidad latina de los Estados Unidos. Gracias a los esfuerzos de prevención, los niveles de contagio entre los latinos se han mantenido estables por más de una década. Sin embargo, esta población sigue siendo afectada a niveles muy altos, en particular entre hombres que tienen sexo con hombres (HSH), de origen latino y que hablan principalmente el idioma español. Existen varios factores que contribuyen a la transmisión del VIH entre esta población, como son: el uso de drogas; la violencia dentro de la pareja; la presencia de infecciones de transmisión sexual; relaciones sexuales sin protección, dentro y fuera de la pareja; el evadir la búsqueda de recursos (prueba y tratamiento adecuado) por temor a ser discriminado o por su estatus migratorio; la escasez de recursos económicos o estado de pobreza y los patrones relacionados a la migración. En particular, Investigaciones Epidemiológicas de Comportamientos han determinado: cómo algunas dinámicas en parejas están directamente asociadas a los comportamientos sexuales de riesgos. En consecuencia, es necesaria mayor investigación para identificar esas dinámicas, y a su vez, realizar intervenciones dirigidas a la reducción de conductas de riesgo enfocadas en parejas de hombres del mismo sexo. En este escrito, se describe la importancia del uso de las relaciones de pareja como estrategia en la reducción de la trasmisión del VIH/SIDA en HSH de origen latino y que hablan principalmente el idioma español en los Estados Unidos.

Martinez, Omar; Wu, Elwin; Sandfort, Theo; Shultz, Andrew Z.; Capote, Jonathan; Chávez, Silvia; Moya, Eva; Dodge, Brian; Morales, Gabriel; Porras, Antonio; Ovejero, Hugo

2014-01-01

360

Evidence for single origins of 35delG and delE120 mutations in the GJB2 gene in Anatolia.  

PubMed

Eighteen different sequence changes, including three novel alterations, were detected in GJB2, encoding connexin 26, in 371 Turkish probands with non-syndromic sensorineural hearing loss. Two frequently detected mutations, 35delG and delE120, were shown to have single origins based on the conserved genotypes of two closely linked microsatellite and five single nucleotide polymorphism markers. Carrier frequencies of 35delG and delE120 in Egypt and Turkic populations of the Near East provide insights about the origin of these two mutations. PMID:15617546

Tekin, M; Bo?oclu, G; Arican, S T; Orman, M N; Tastan, H; Elsobky, E; Elsayed, S; Akar, N

2005-01-01

361

Identificación de los miembros del cúmulo NGC 2516  

NASA Astrophysics Data System (ADS)

El cúmulo abierto NGC 2516 (? = 7h 58m y ? = -60o 45') tiene una edad de, aproximadamente, 150 Myr. El análisis de este sistema es particularmente importante en el Hemisferio Sur debido a su abundancia de estrellas peculiares y muy estudiado aplicando técnicas fotométricas, pero muy poco analizado desde el punto de vista astrométrico. A partir de una placa obtenida en el Observatorio Astronómico de La Plata y observaciones más actuales, nos hemos abocado al estudio de los movimientos propios de este cúmulo con el fin de determinar la pertenencia al mismo de las estrellas del campo de dicho cúmulo. Luego de llevar a cabo la determinación de los movimientos propios de todas las estrellas a partir de las posiciones obtenidas de la placa existente en el Observatorio de La Plata de 1914 y leídas con la MAMA en París, las observaciones realizadas con el círculo meridiano de San Fernando que se encuentra en el Observatorio Félix Aguilar de San Juan y las posiciones existentes en los catálogos AC 2000, Tycho, USNO y UCAC, programamos el método de Vasilevsky y Sanders para determinar la pertenencia de las estrellas de la región al cúmulo en cuestión. En un paso posterior, se realizó una modificación al método anterior para la determinación de los miembros. En esta modificación se consideró la densidad de las estrellas del cúmulo y la densidad de estrellas de campo. Esto permitió evaluar la pertenencia, no sólo a partir del movimiento propio de las estrellas, sino también a partir de la posición de las mismas con respecto al centro del cúmulo. También se consideró la dependencia de los parámetros con la magnitud. Los resultados así obtenidos fueron comparados con otras investigaciones de movimientos propios de la región del cúmulo. El movimiento propio absoluto del cúmulo fue comparado con el obtenido a partir de los catálogos estelares. Se encontró que los resultados coincidían para estrellas brillantes (magnitud más brillante que 12.0 aproximadamente) y que no coincidían para estrellas más débiles. La tarea que llevamos a cabo en estos momentos está referida a encontrar la causa de tales discrepancias con el fin de obtener los mejores resultados.

de Elía, G. C.; Orellana, R. B.

362

Analisis del contenido curricular de los Documentos Normativos del Programa de Ciencias en el area de biologia para la escuela superior del sistema de educacion publica de Puerto Rico: 1993-2012  

NASA Astrophysics Data System (ADS)

Esta investigacion de naturaleza cualitativa se ocupo de realizar un analisis de contenido documental de los Documentos Normativos del Programa de Ciencias en el area de biologia de la escuela superior del sistema de educacion publica de Puerto Rico del periodo 1993-2012. Los documentos analizados fueron: Guia Curricular, 1995; Marco Curricular, 2003; Estandares de Excelencia, 1996, 2000 y Estandares de Contenido y Expectativas de Grado, 2007. Se indago si hubo cambios en significados en los Componentes Estructurales: Naturaleza de la ciencia, Paradigmas para la ensenanza de la ciencia, Funcion del curriculo formal, Mision de la ensenanza de la ciencia; Contenidos, destrezas y competencias, Estrategias de ensenanza y Evaluacion/Assessment del aprendizaje. El analisis sugiere que no hubo cambios sustanciales en los significados de los Componentes Estructurales. Los documentos estudiados muestran mayormente caracteristicas similares, aunque los documentos mas recientes eran mas descriptivos, explicativos y especificos.

Davila Montanez, Melissa

363

Propuesta de un mecanismo de estabilización de precios de los combustibles a través del uso de instrumentos financieros derivados  

Microsoft Academic Search

El presente estudio propone la discusión de los fundamentos de la utilización de un mecanismo basado en el uso de instrumentos financieros de cobertura para la mitigación del impacto de la volatilidad del precio del petróleo en el costo de sus productos derivados. A fin de contribuir a la consideración de alternativas se plantea aquí también la posible complementación del

Juan Antonio Zapata; Carlos Gabriel Rivas; Alejandro Melandri

2012-01-01

364

AREA ANEP REFERENCIA NOMBRE CENTRO PROVINCIA FISICA Y CIENCIAS DEL ESPACIO 11-675-01-01 GIANLUCA CALGAGNI IEM MADRID  

E-print Network

AREA ANEP REFERENCIA NOMBRE CENTRO PROVINCIA FISICA Y CIENCIAS DEL ESPACIO 11-675-01-01 GIANLUCA CALGAGNI IEM MADRID FISICA Y CIENCIAS DEL ESPACIO 11-675-01-02 MERCEDES LOPEZ MORALES ICE BARCELONA FISICA Y CIENCIAS DEL ESPACIO 11-675-01-03 MICHELE DELLA MORTE IFIC VALENCIA FISICA Y CIENCIAS DEL ESPACIO

Fitze, Patrick

365

La "conversione" delle cellule della cute che producono insulina: nuova arma contro diabete e tumore del pancreas  

E-print Network

tumore del pancreas Uno studio dell'Università degli Studi di Milano su PNAS scopre un metodo, sicuro alterarne il DNA. Straordinarie le potenzialità nella terapia del diabete e del tumore al pancreas. La i vari tipi di diabete e per il tumore del pancreas. La ricerca, finanziata da AIRC, MIUR e Regione

De Cindio, Fiorella

366

El camino México-Toluca. Proyecto del ingeniero militar Manuel Agustín Mascaró. Nueva España, 1791–1795  

Microsoft Academic Search

En este estudio exponemos diversos asuntos y circunstancias que acontecieron en torno al proyecto del camino México-Toluca realizado por el ingeniero militar Manuel Agustín Mascaró. Comenzamos con un esbozo biográfico del autor y una descripción general del proyecto para continuar con la explicación del contexto histórico en que se realizó tanto el manuscrito como la obra, desde la importancia socio-económica

María del Carmen León García

2007-01-01

367

Prognostic Impact of del(17p) and del(22q) as Assessed by Interphase FISH in Sporadic Colorectal Carcinomas  

PubMed Central

Background Most sporadic colorectal cancer (sCRC) deaths are caused by metastatic dissemination of the primary tumor. New advances in genetic profiling of sCRC suggest that the primary tumor may contain a cell population with metastatic potential. Here we compare the cytogenetic profile of primary tumors from liver metastatic versus non-metastatic sCRC. Methodology/Principal Findings We prospectively analyzed the frequency of numerical/structural abnormalities of chromosomes 1, 7, 8, 13, 14, 17, 18, 20, and 22 by iFISH in 58 sCRC patients: thirty-one non-metastatic (54%) vs. 27 metastatic (46%) disease. From a total of 18 probes, significant differences emerged only for the 17p11.2 and 22q11.2 chromosomal regions. Patients with liver metastatic sCRC showed an increased frequency of del(17p11.2) (10% vs. 67%;p<.001) and del(22q11.2) (0% vs. 22%;p?=?.02) versusnon-metastatic cases. Multivariate analysis of prognostic factors for overall survival (OS) showed that the only clinical and cytogenetic parameters that had an independent adverse impact on patient outcome were the presence of del(17p) with a 17p11.2 breakpoint and del(22q11.2). Based on these two cytogenetic variables, patients were classified into three groups: low- (no adverse features), intermediate- (one adverse feature) and high-risk (two adverse features)- with significantly different OS rates at 5-years (p<.001): 92%, 53% and 0%, respectively. Conclusions/Significance Our results unravel the potential implication of del(17p11.2) in sCRC patients with liver metastasis as this cytogenetic alteration appears to be intrinsically related to an increased metastatic potential and a poor outcome, providing additional prognostic information to that associated with other cytogenetic alterations such as del(22q11.2). Additional prospective studies in larger series of patients would be required to confirm the clinical utility of the new prognostic markers identified. PMID:22912721

González-González, María; Muñoz-Bellvis, Luís; Mackintosh, Carlos; Fontanillo, Celia; Gutiérrez, M. Laura; Abad, M. Mar; Bengoechea, Oscar; Teodosio, Cristina; Fonseca, Emilio; Fuentes, Manuel; De Las Rivas, Javier

2012-01-01

368

Le Thorium Molten Salt Reactor : Au del du MSBR  

E-print Network

Le Thorium Molten Salt Reactor : Au delà du MSBR L. Mathieu, D. Heuer, A. Billebaud, R. Brissot, C réflexion est menée afin de trou- ver des solutions et ainsi d'aboutir au concept du Thorium Mol- ten Salt optimale du minerai d'uranium ou de thorium, une conception résistante à la prolifération, une meilleur

Paris-Sud XI, Université de

369

ESTUDIO HIDROQUIMICO DEL ACUFERO DE LA VEGA DE GRANADA  

E-print Network

Aguas de superficie Aguas residuales urbanas Aguas residuales industriales Aguas de infiltración. El el título, sobre la hidroquímica (calidad y contaminación) de las aguas de la Vega de Granada. En) Confederación Hidrográfica y Comisaría de Aguas del Guadalquivir (Granada) Colegio farmacéutico y Consejería de

Castillo, Antonio

370

El presidente Obama anuncia nombramiento del doctor Harold Varmus  

Cancer.gov

En un correo electrónico enviado al personal del NCI, el doctor Francis Collins, director de los Institutos Nacionales de la Salud, dijo que Varmus “trae consigo un experiencia sin igual a todo nivel, no solo en la investigación científica más avanzada, sino también como líder en la creación de estrategias para mejorar el cuidado de los pacientes, la educación científica, la capacitación y el diseño de novedosas alianzas entre el sector público y el privado”.

371

Weak approximation on del Pezzo surfaces of degree 1  

E-print Network

We study the arithmetic of del Pezzo surfaces of degree 1 of the form w^2 = z^3 + Ax^6 + By^6 in the weighted projective space P_k(1,1,2,3), where k is a perfect field of characteristic not 2 or 3 and A,B \\in k^*. We exhibit an infinite family of (minimal) counterexamples to weak approximation amongst these surfaces, via a Brauer-Manin obstruction.

Várilly-Alvarado, Anthony

2008-01-01

372

del(7q) in chronic B-cell lymphoid malignancies  

Microsoft Academic Search

Twelve patients with diagnosis of B-cell non-Hodgkin's lymphoma\\/leukemia and del(7q) were studied for their clinical, cytogenetic, and molecular characteristics. Eleven patients were classified as small cell lymphoma whereas one had a diffuse large cell lymphoma. Lymphoplasmacytic features were observed in six out of eleven small cell lymphomas. Morphologically and immunologically these small cell lymphomas could be classified as chronic lymphocytic

Jesús María Hernandez; Cristina Mecucci; Lucienne Michaux; Arnold Criel; Michel Stul; Peter Meeus; Iwona Wlodarska; Angeline Van Orshoven; Jean-Jacques Cassiman; Christiane De Wolf-Peeters; Herman Van Den Berghe

1997-01-01

373

Las ciudades de Andalucía ante la sociedad del conocimiento  

Microsoft Academic Search

La relación entre competitividad económica y posicionamiento de los territorios en la sociedad del conocimiento cobra cada vez mayor protagonismo. Despiertan así especial interés aquellos ámbitos que realizan un esfuerzo por incrementar la producción, difusión y aplicación de conocimiento para mejorar el funcionamiento de sus empresas y la calidad de vida de sus habitantes.\\u000aPor su parte, las ciudades se

Ricardo Méndez Gutiérrez del Valle; Luis Abad Aragón; Inmaculada Caravaca Barroso; Gema González Romero

2010-01-01

374

Maximally inhomogeneous G\\"{o}del-Farnsworth-Kerr generalizations  

E-print Network

It is pointed out that physically meaningful aligned Petrov type D perfect fluid space-times with constant zero-order Riemann invariants are either the homogeneous solutions found by G\\"{o}del (isotropic case) and Farnsworth and Kerr (anisotropic case), or new inhomogeneous generalizations of these with non-constant rotation. The construction of the line element and the local geometric properties for the latter are presented.

Wylleman, Lode

2012-01-01

375

La computacin y sus versiones : El Debate del Software  

E-print Network

La computación y sus versiones : El Debate del Software Software Libre vs. Software Privativo Pablo controladas por el código (el software). Pero ... ¿Quién controla el código? ¿De quién recibe órdenes tu computadora? ¿Tenemos derecho a saber exactamente qué hace nuestra computadora? #12;¿Qué es el Software Libre

De Nápoli, Pablo Luis

376

Teoria simmetrica dell’elettrone e del positrone  

Microsoft Academic Search

Sunto  \\u000a Si dimostra la possibilità di pervenire a una piena simmetrizzazione formale della teoria quantistica dell’elettrone e del\\u000a positrone facendo uso di un nuovo processo di quantizzazione. Il significato delle equazioni di\\u000a Dirac\\u000a ne risulta alquanto modificato e non vi è più luogo a parlare di stati di energia negativa; nè a presumere per ogni altro\\u000a tipo di particelle, partieolarmente

Ettore Majorana

1937-01-01

377

María Asunción Requena: Éxito e historia del teatro  

E-print Network

Universidad de Concepción. Ganó el Premio al XXX aniversario del DETUCH (Departamento de Teatro de la Universidad de Chile) con Chiloé, cielos cubiertos en 1971. Este texto fue puesto en escena en 1972 en Santiago. En el mismo año se estrenó en Santiago... Televisión dieron mucha importancia a la posibilidad de atraer teleespectadores con el renombre y prestigio de los actores y actrices: Roberto Parada, Rafael Benavente, Teodoro Lowey, Tennyson Ferrada, Ana González, Sonia Viveros y otros. Veintiocho...

Villegas, Juan

1995-04-01

378

Récord de longevidad del Correlimos Zarapitín (Calidris ferruginea)  

Microsoft Academic Search

En aquesta nota es descriu el control d'un territ bec-llarg disset anys després del seu anellament. L'ocell es va marcar com a jove el 5 de setembre de 1975 a Friesland (Holanda) i es va recapturar el 3 d'agost de 1992 al delta de l'Ebre, 6173 dies després de l'anellament. Fins ara la màxima longevitat demostrada per a aquesta espècie

Jordi Figuerola

1995-01-01

379

Wetlands of the Magellanic Steppe (Tierra Del Fuego, Argentina)  

Microsoft Academic Search

Our main objective was to classify vegetation and soils of wetlands in northern Tierra del Fuego (Argentina) along a latitudinal\\u000a precipitation gradient within the Magellanic Steppe Zone. We presented the first detailed ecological characterization of these\\u000a wetlands by relating floristic composition to local site conditions, bedrock and climate. The survey consisted of 125 phytosociological\\u000a censuses and 52 soil profile descriptions.

Marta B. Collantes; Juan A. Anchorena; Susana Stoffella; Celina Escartín; Ruth Rauber

2009-01-01

380

PRCTICAS OCULTAS DE LOS "ANUSI11" DEL NUEVO MUNDO  

E-print Network

PRÁCTICAS OCULTAS DE LOS "ANUSI11" DEL NUEVO MUNDO ScHL:lA\\llTH C. H ALEVY* N ..\\CHl!'.1 DERSHO\\\\'ITZ* \\1CCHOS de los judíos de España y Portugal que fueron obligados a con- \\'ertirse al cristianismo (llamados anusim en hebreo) y sus descendientes, emigraron a América.1 Sabemos por los archivos de la Santa

Dershowitz, Nachum

381

Solar adaptive optics at the Observatorio del Teide, Tenerife  

NASA Astrophysics Data System (ADS)

Observing the Sun with high angular resolution is difficult because the turbulence in the atmosphere is strongest during day time. In this paper we describe the principles of solar adaptive optics exemplified by the two German solar telescopes VTT and GREGOR at the Observatorio del Teide. With theses systems we obtain near diffraction limited images of the Sun. Ways to overcome the limits of conventional AO by applying multiconjugate adaptive optics (MCAO) are shown.

Soltau, Dirk; Berkefeld, Thomas; Schmidt, Dirk; von der Lühe, Oskar

2013-10-01

382

EMPLAZAMIENTO DE NIDOS DE ARDILLA ROJA Sciurus vulgaris EN MELOJARES Y SETOS ARBOLADOS DEL VALLE DEL RÍO TORÍO (LEÓN, NO DE ESPAÑA)  

Microsoft Academic Search

RESUMEN Se describe el emplazamiento de 49 nidos de ardilla roja Sciurus vulgaris en setos arbolados (n=28), plantaciones de chopos (n=14) y bordes de melojares (n=7) del valle del río Torío (León). Todos los nidos encontrados en melojares y plantaciones de chopos estaban instalados en melojos Quercus pyrenaica y chopos híbridos Populus x canadensis, respectivamente, debido al carácter prácticamente monoespecífico

A. HERNÁNDEZ

383

Nuevo sitio web en español del Instituto Nacional del Cáncer, (NCI, por sus siglas en inglés) Cancer.gov en español - Silvia Inéz Salazar - transcript  

Cancer.gov

Transmisiones de radio para promover Cancer.gov en espa%XF1ol | Nuevo sitio web en espa%XF1ol del Instituto Nacional del C%XE1ncer, (NCI, por sus siglas en ingl%XE9s) Cancer.gov en espa%XF1ol | Transcripci%XF3n Transmisiones de radio para promover

384

PROPUESTA DE UN SISTEMA DE GESTIÓN DE LOS COSTOS DE CALIDAD EN LA AGROINDUSTRIA ARROCERA DEL CAI FERNANDO ECHENIQUE DEL MUNICIPIO YARA  

Microsoft Academic Search

El trabajo fue realizado en la agroindustria arrocera del CAI Fernando Echenique ubicado en la Provincia Granma, en el cual se concentra el 70 por ciento de la producción de arroz de la región oriental del país. El estudio abarcó las Granjas arroceras Bartolomé Masó Márquez y Pedro Borrás Astorga, y la Unidad industrial de Beneficio Emilio Lastre, a partir

Yudelquis Ramírez Pérez; Sandy Rodríguez Sosa; Odalis Reyes Alarcón

2012-01-01

385

El barrio del Raval de Barcelona (1999-2008). Transformaciones urbanas y nuevos enfoques metodológicos para el estudio del centro histórico  

Microsoft Academic Search

Los centros históricos de las ciudades europeas experimentan actualmente importantes transformaciones urbanas que han contribuido a que dichas áreas se convirtieran en objeto de estudio por parte de distintas disciplinas. Éste es el caso del centro histórico de Barcelona, particularmente el barrio del Raval, cuyos cambios en los últimos diez años (1999-2008) se han abordado desde áreas de conocimiento como

Ma. Alba Sargatal Bataller

2009-01-01

386

The 2012 Reactivation of Nevado del Ruiz Volcano, Colombia  

NASA Astrophysics Data System (ADS)

Nevado Del Ruiz volcano is most known for its tragic November 13, 1985 explosive event, when a small eruption produced an enormous lahar that buried and destroyed the town of Armero in Tolima, causing an estimated 25,000 deaths. Similar but less deadly incidents occurred in 1595 and 1845, again where a small explosive eruption was followed by a large lahar. Other minor explosive events occurred in 1805, 1828-9, and 1989. The Armero tragedy was a major factor in the establishment of a volcano monitoring program in Colombia. The network monitoring Nevado del Ruiz volcano has dramatically improved since the 1985 eruption and now includes geodetic, geophysical, geochemical and visual monitoring. The activity of Nevado Del Ruiz between 1985 and 1991 saw significant increases in seismicity and significant gas emissions with the main eruptive events of November 13, 1985 and September 1st, 1989. The volcano became seismically active again in 1995 and 2002, whit an increase in seismicity, without any gas emission or eruption. In October 2010 the volcano entered in a new phase of unrest with increased seismicity (HB events), deformation and gas emissions, likely associated with a new magma intrusion. In February, 2012 the volcano had a new and significant increase in seismicity (VT-LP), followed in May and June 2012 by small phreatic and phreato-magmatic eruption. This eruptive activity is still ongoing. Deformation measurements at Nevado Del Ruiz volcano have been carried out since just after the tragic eruption of the 13th of November 1985. In 2007 seven new electronic tilt meters were set up to monitor the deformation. Significant uplift was measured from August 2007 to October 2010, for a total cumulative value of more than 500 microradians. From the end of 2011 to July 2012, moderate changes of uplift were detected for a total of 70 microradians. The analysis of these deformation data shows a pattern of surface displacement associated with an intrusion of new magma coming from a reservoir located approximately at a depth of approximately 8 km and accumulating in shallow reservoir less than 2 km beneath the main crater. We fit the data with both a spherical and a vertical spheroid source. The spherical source indicates the existence of an intrusion at a depth of 1823±1056 m with a volume change of (7±17)×106 m3 . The vertical spheroidal source suggests a source 1855 m deep with a volume change of 6×106 m3 . These results imply that while we have strong bounds on the depth of the intrusion, the actual volume of the source is less certain. Gas emission from Nevado del Ruiz volcano in April 7, 2012.

Ordoñez, M.; Lopez, C.; Cortes, G. P.; Londoño, J.; Battaglia, M.

2012-12-01

387

EL JARDN BOTNICO DE NUEVA YORK POLTICA DE ADQUISICIONES DEL DEPSITO DE ADN  

E-print Network

EL JARDÍN BOTÁNICO DE NUEVA YORK POLÍTICA DE ADQUISICIONES DEL DEP�SITO DE ADN El depósito de ADN y de ADN genómico para investigaciones conducidas por científicos, estudiantes de post misión del Jardín para documentar la biodiversidad, la meta del depósito de ADN es almacenar muestras de

Law, Wayne

388

Exito para el XVI Festival Internacional de Teatro Hispano del Teatro Avante  

E-print Network

una brillante producción de Cenizas sobre el mar del dramaturgo colombiano José Assad. La obra fue escrita entre 1988-9, estrenada en Bogotá en 1990 y presentada en el Teatro Colón de Miami Beach, la única del festival puesta fuera del Teatro... musicales de Mike Porcel, los cuales hicieron de esta producción evento sumamente dramático, en el mejor sentido de la palabra. No menos valiente fue la dirección predominantemente de Lilliam Vega, según la propia admisión de Mario Ernesto Sánchez. Esto...

Marrero, Marí a Teresa

2002-04-01

389

Contribución al flujo infrarrojo de las estrellas Be de la recombinación dielectrónica del MgII  

NASA Astrophysics Data System (ADS)

Para evaluar la contribución del proceso de recombinación dielectrónica del átomo de MgII al exceso de flujo infrarrojo observado en las estrellas Be, calculamos la energía emitida en las líneas originadas por este proceso. Se evaluaron los efectos de las condiciones físicas del medio, como la temperatura electrónica y la densidad electrónica, sobre el flujo emitido. Se consideró también la influencia de una posible opacidad.

Cruzado, A.; di Rocco, H.; Ringuelet, A.

390

Quíntuples y el vértigo del teatro autoreflexivo de Luis Rafael Sánchez  

E-print Network

SPRING 1994 39 Quintuples y el vértigo del teatro autorreflexivo de Luis Rafael Sánchez Hortensia R. Morell La inscripción del escritor puertorriqueño Luis Rafael Sánchez dentro de la postmodernidad se manifiesta ya en su primera novela La... guaracha del Macho Camacho (1976). Su inagotable diálogo intertextual, su constante cuestionamiento de los límites genéricos, su escritura como experiencia misma de ruptura y dislocación lingüística, sus dimensiones paródicas y autoparódicas ciertamente...

Morell, Hortensia R.

1994-04-01

391

Visió històrica dels incendis forestals al Port de Tortosa els segles XIV i XV  

Microsoft Academic Search

S'ha estudiat el règim d'incendis al Port de Tortosa des de 1370 aD a 1466 aD a partir dels llibres de claveria de Tortosa. Aquests llibres contenen la comptabilitat de la ciutat, incloenthi el pagament de les despeses que es produï-en en l'extinció d'incendis dels boscos que tenia la ciutat en règim d'usdefruit. La magnitud dels focs s'ha estimat a

Gerard Marí i Brull; Francisco Lloret

2001-01-01

392

Visual and Near-IR Photometry of Nova Del 2013  

NASA Astrophysics Data System (ADS)

We report Visual and Near-IR photometry of Nova Del 2013 taken at the University of Minnesota's O'Brien Observatory (Marine-on-St-Croix, Minnesota, USA). VRIJHKLM photometry were obtained on two successive nights using an AsSi bolometer. Vega (alpha Lyrae) was used as the standard star. Our photometry show: August 16.2 UT: V = 4.8 +/- 0.1, R = 5.4 +/- 0.1, I = 5.2 +/- 0.1, J = 4.4 +/- 0.1, H = 4.3 +/- 0.1, K = 4.3 +/- 0.1, L = 4.5 +/- 0.2.

Gehrz, R. D.; Dykhoff, D. A.; Shenoy, D. P.

2013-08-01

393

Optical photometry and spectroscopy of Nova Del 2013  

NASA Astrophysics Data System (ADS)

We report optical BV photometry and spectroscopy of Nova Del 2013, carried out between August 14.88 UT and August 15.08 UT. Using a 60 cm Cassegrain telescope at the Nicolaus Copernicus University Observatory (Torun, Poland) we estimated the V brightness of the Nova to be 6.31+/-0.02 mag and 6.18+/-0.03 mag on Aug. 14.94 UT and Aug. 15.02 UT respectively. HD 194113 (F2, V=8.00 mag) was used as a comparison star.

Tomov, T.; Ilkiewicz, K.; Swierczynski, E.; Belcheva, M.; Dimitrov, D.

2013-08-01

394

EJERCICIO Y LA DETECCION DEL MAL AGUDO DE MONTAÑA GRAVE  

PubMed Central

El Mal Agudo de Montaña (MAM) es un conjunto de síntomas inespecíficos padecidos por sujetos que ascienden rápidamente desde baja a alta altura sin adecuada aclimatación. Usualmente es autolimitado, pero las formas graves (edema pulmonar y cerebral) pueden causar la muerte. La hipoxemia exagerada en reposo está relacionada con el desarrollo de MAM pero su valor predictivo es limitado. Dado que el ejercicio en altura se acompaña de mayor hipoxemia y síntomas, postulamos el valor predictivo de un simple test de ejercicio para pronosticar MAM grave. Se estudió el valor predictivo de la saturación de oxígeno en reposo y ejercicio submáximo a 2 700m y 4 300m en 63 sujetos que ascendían al cerro Aconcagua (6 962m). Se consideró desaturación de oxígeno con ejercicio a una disminución >=5% respecto al reposo. Se utilizó la escala de Lake-Louise para establecer la presencia de MAM grave. 6 sujetos presentaron MAM grave (9.5%) y requirieron evacuación. La saturación de oxígeno en reposo a 2 700m no fue significativa para clasificar sujetos que luego desarrollaron MAM grave. Por el contrario, la asociación de desaturación durante el ejercicio a 2 700m más la saturación inapropiada en reposo a 4 300m fue significativa para clasificar a los sujetos que desarrollaron MAM grave con un valor predictivo positivo de 80% y un valor predictivo negativo del 97%. Nuestros resultados son relevantes para el montañismo y sugieren la adición de un simple test de ejercicio en la predicción del MAM grave. PMID:20228017

Garófoli, Adrián; Montoya, Paola; Elías, Carlos; Benzo, Roberto

2012-01-01

395

La revisión del estudio de prevención de cáncer de próstata indica no haber beneficio del uso de suplementos de selenio y de vitamina E  

Cancer.gov

La revisión inicial, independiente, de los datos del estudio SELECT, sigla en inglés del Estudio del Selenio y la Vitamina E para Prevenir el Cáncer, financiado por el Instituto Nacional del Cáncer (NCI) y otros institutos que comprenden los Institutos Nacionales de la Salud (NIH), indica que los suplementos de selenio y de vitamina E, tomados juntos o por separado, no impiden el cáncer de próstata. Los datos indicaron también dos tendencias preocupantes: un pequeño aumento aunque no significativo estadísticamente en el número de casos de cáncer de próstata entre los más de 35 000 hombres de 50 años y mayores en el estudio que tomaron sólo vitamina E, y un aumento pequeño aunque no significativo estadísticamente en el número de casos de diabetes de aparición en edad adulta en los hombres que tomaron sólo el selenio.

396

El Instituto Nacional del Cáncer publica nuevo atlas de mortalidad por cáncer  

Cancer.gov

El Instituto Nacional del Cáncer (NCI, por sus siglas en inglés) ha publicado un nuevo atlas, el Atlas de Mortalidad por Cáncer en los Estados Unidos, 1950-94, que muestra los patrones geográficos de las tasas de mortalidad por cáncer durante más de cuatro décadas, en más de 3.000 condados a lo largo del país.

397

BOLETN OFICIAL DEL ESTADO Nm. 167 Sbado 13 de julio de 2013 Sec. III. Pg. 52257  

E-print Network

DISPOSICIONES MINISTERIO DE EDUCACI�N, CULTURAY DEPORTE 7736 Resolución de 28 de junio de 2013, de la Secretaría.01 del Presupuesto de gastos del Ministerio de Educación, Cultura y Deporte. Artículo 3. Cuantía de las

Oro, Daniel

398

En el ao 1991se creaba el Insti-tuto Universitario del Agua y las  

E-print Network

en el tratamiento de aguas residuales industriales, experien- cias de reutilización de aguas resiEn el año 1991se creaba el Insti- tuto Universitario del Agua y las Ciencias otra denominación, se imparte el máster Gestión Sostenible y Tec- nología del Agua, adaptado al Es

Escolano, Francisco

399

Desajustes del tipo de cambio en países en vías de desarrollo  

Microsoft Academic Search

Este artículo analiza la teoría del tipo de cambio real (TCR) de equilibrio y define el desajuste como una desviación del TCR de su nivel de equilibrio. Luego, se analiza el rol de la política macroeconómica bajo tres regímenes alternativos de tipo de cambio nominal: tipos de cambio nominal predeterminado (fijado), tipo de cambio nominal flotante y tipos de cambio

Sebastián Edwards

400

Boletín No 11: Caracterización del Trabajo Independiente y su Afiliación a la Seguridad Social en Colombia  

Microsoft Academic Search

El tema central del presente Boletín es aparentemente un tema de coyuntura. En efecto, la afiliación del trabajador independiente al sistema de seguridad social integral está generando arduos debates, económicos y jurídicos, desde la implementación de la Planilla Integrada de Liquidación de Aportes –PILA- a mediados de este año. Sin embargo, el trabajo independiente en relación a la seguridad social

Stefano Farne; Jesus Perdomo; Carlos Andrés Vergara

2008-01-01

401

SELECCION DEL HABITAT DE NIDIFICACION POR EL BUHO REAL (BUBO BUBO) EN NAVARRA  

E-print Network

SELECCION DEL HABITAT DE NIDIFICACION POR EL BUHO REAL (BUBO BUBO) EN NAVARRA Los conocimientosactualessobre selección de nido por el Búho Real (Bubo bubo) son extensos en lo relativo a fisionomía de los stippkd orea reprwcms (he &ntbvtiod rmge of B. bubo.] #12;SELECCION DEL HABITAT POR EL BUHO REAL Censo La

Donázar, José A.

402

La elasticidad PIB del gasto social en países seleccionados en América Latina  

Microsoft Academic Search

En este documento se caracteriza la relación entre el gasto social, sus clasificaciones funcionales y el PIB en la región en el período 1980-2008 a través de la estimación de las elasticidades PIB de corto y de largo plazo del gasto social y sus componentes para diez países seleccionados de América Latina. Desde el punto de vista del corto plazo,

Omar Bello; Ramiro Ruiz del C

2011-01-01

403

ANÁLISIS DE INCIDENCIA DEL GASTO PÚBLICO EN EDUCACIÓN SUPERIOR: NUEVAS APROXIMACIONES  

Microsoft Academic Search

Los estudios de incidencia del gasto se han contrastado de forma empírica fundamentalmente a través de la metodología de incidencia normativa del gasto, técnica que cuenta con importantes limitaciones, algunas de ellas insalvables. Intentando ofrecer nuevos enfoques, existen líneas de investigación que tratan de incluir comportamiento, y derivadas de éstas, otras aproximaciones que intentan estudiar conjuntamente comportamiento e incidencia, aunque

María Gil Izquierdo

404

La educación en Colombia: Análisis del marco normativo y de los indicadores sectoriales  

Microsoft Academic Search

En este documento se presenta una visión amplia de los problemas y del funcionamiento del sector educativo en Colombia, con énfasis en la educación pública. Inicialmente, se realiza una breve descripción de la política educativa durante las últimas décadas. Posteriormente, se realiza una evaluación detallada de las normas sobre descentralización educativa, así como de aquellas que rigen la carrera docente

Ana María Iregui; Ligia Melo; Jorge Ramos

2006-01-01

405

Ricerche morfologiche ed istochimiche sulla glia del nevrasse di vertebrati. II? uccelli  

Microsoft Academic Search

Con metodi istochimici per la dimostrazione del mucopolisaccaridi e con metodi morfologici (colorazioni e impregnazioni dei gliociti) gli autori hanno studiato la glia del nevrasse di diverse specie di uccelli (Gallus G., Meleagris gallopavo, Anas domestica, Anas penelope, Columba livia, Coturnix coturnix, Passer Italiae) in proseguimento di ricerche similari condotte sugli anfibi.

A. Bairati; E. Bartoli

1955-01-01

406

¡Hágale, hermano!:Secuestro, narcotráfico y otras alegres audacias del M-19  

Microsoft Academic Search

El informe de la Comisión de la Verdad sobre el Palacio de Justicia y las declaraciones del ex magistrado José Roberto Herrera al hacerlo público, ponen en manifiesto un tema poco tratado en el análisis del conflicto colombiano, pero que es pertinente para entender su evolución a mediados de los ochenta: las relaciones entre el M-19 y el tráfico de

Mauricio Rubio

2001-01-01

407

La seguridad social en el Perú: su eficacia y eficiencia a través del ciclo económico  

Microsoft Academic Search

Este artículo se distingue de otros que tratan sobre la eficacia y eficiencia de la seguridad social por discutir la eficiencia a partir de la tipificación de funciones de producción y, sobretodo, por incorporar al ciclo económico en el análisis del funcionamiento del IPSS, al sostener que la racionalidad, y por tanto el comportamiento, de los agentes involucrados se operacionaliza

Margarita Petrera Pavone

1987-01-01

408

Las micro-finanzas en Indonesia y el sistema de unidad BRI: Caso del Banco Rakyat  

Microsoft Academic Search

Indonesia tiene una historia de un siglo en proyectos de micro finanzas, que va desde el establecimiento del Badan Kredit Desa (instituciones de crédito comunitario) en 1898, hasta el presente, con una gran variedad de instituciones formales y semiformales de micro-crédito rural a nivel comunitario. A pesar del éxito de esas instituciones de micro finanzas, para sostener sus operaciones con

Sumantoro Martowijoyo

2001-01-01

409

Un analisis econometrico del turismo hotelero y extra-hotelero en las regiones y provincias españolas  

Microsoft Academic Search

Se presentan algunos modelos econometricos de las regiones españolas para analizar la distribucion del turismo, hotelero y extrahotelero a nivel regional y provincial de España en 1991-95. El enfoque resulta novedoso al incluir el estudio del turismo extra-hotelero que tiene en muchos casos gran importancia. Los modelos ponen de manifiesto la importancia de varios factores como el clima, en todos

M. Carmen Guisan; Neira I

2001-01-01

410

EVOLUCION DEL TURISMO HOTELERO EN LAS REGIONES ESPAÑOLAS, 2001-2008  

Microsoft Academic Search

Analizamos la evolución del turismo hotelero en el período 2001-2008, en las regiones y provincias españolas, utilizando las estadísticas de pernoctaciones hoteleras como indicador. Presentamos una síntesis de resultados de varios modelos econométricos del turismo regional en España, tanto en lo que respecta a los factores que influyen en el desarrollo turístico como al impacto que el turismo tiene en

M. C. Guisan; E. Aguayo

2008-01-01

411

Modelo gravitatorio y turismo: Una aplicación a los flujos monetarios interregionales del sector Turismo en España  

Microsoft Academic Search

RESUMEN: Este trabajo analiza los flujos monetarios domésticos del sector Turismo en España mediante diferentes especificaciones del modelo gravitatorio, aplicados a tres estimaciones alternativas de los flujos monetarios bilaterales. Los modelos han permitido identificar las principales variables que actúan como factores de atracción de los flujos interregionales, obteniendo elasticidades diferentes para la variable distancia a las observadas en los flujos

Tamara de la Mata; Carlos Llano

2010-01-01

412

El cuento del cáncer de cérvix podría tener un final feliz  

Cancer.gov

El cuento del cáncer de cérvix podría tener un final feliz Por el Instituto Nacional del Cáncer El cáncer de cérvix fue en un tiempo la causa principal de muerte por cáncer entre mujeres estadounidenses. Pero, en los últimos 50 años, el número de

413

Movilidad social en el asentamiento subnormal de Ranchos del Inat 2004  

Microsoft Academic Search

En este documento se cuantificó la movilidad social educativa en el asentamiento subnormal de Ranchos del Inat, entre padres e hijos, por dos métodos. Primero se determinaron las probabilidades que tienen los hijos de superar la educación de sus padres, a partir del nivel educativo alcanzado por ellos. Segundo se construyeron matrices de transición por medio de un modelo probit

Rosaura Arrieta; Aura García; Elsa Doria

2005-01-01

414

Independent External Peer Review Rio Grande Floodway, San Acacia to Bosque Del Apache,  

E-print Network

Independent External Peer Review Rio Grande Floodway, San Acacia to Bosque Del Apache, New Mexico and maintenance Office of Management and Budget Probability of Unsatisfactory Performance SADD San Acacia performed an Independent External Peer Review (IEPR) of the Rio Grande Floodway, San Acacia to Bosque Del

US Army Corps of Engineers

415

Estimaciones de Prevalencia del VIH por Género y Grupo de Riesgo en Tijuana, México: 2006  

PubMed Central

OBJETIVO Estimar la prevalencia del VIH en adultos de 15-49 años de edad en Tijuana, México - en la población general y en subgrupos de riesgo en el 2006. METODOS Se obtuvieron datos demográficos del censo Mexicano del 2005, y la prevalencia del VIH se obtuvo de la literatura. Se construyó un modelo de prevalencia del VIH para la población general y de acuerdo al género. El análisis de sensibilidad consistió en estimar errores estándar del promedio-ponderado de la prevalencia del VIH y tomar derivados parciales con respecto a cada parámetro. RESULTADOS La prevalencia del VIH es 0.54%(N = 4,347) (Rango: 0.22%–0.86%, (N = 1,750–6,944)). Esto sugiere que 0.85%(Rango: 0.39%–1.31%) de los hombres y 0.22%(Rango: 0.04%–0.40%) de las mujeres podrían ser VIH-positivos. Los hombres que tienen sexo con hombres (HSH), las trabajadoras sexuales usuarias de drogas inyectables (MTS-UDI), MTS-noUDI, mujeres UDI, y los hombres UDI contribuyeron las proporciones más elevadas de personas infectadas por el VIH. CONCLUSIONES El número de adultos VIH-positivos entre subgrupos de riesgo en la población de Tijuana es considerable, marcando la necesidad de enforcar las intervenciones de prevención en sus necesidades específicas. El presente modelo estima que hasta 1 en cada 116 adultos podrían ser VIH-positivos. PMID:19685824

Iñiguez-Stevens, Esmeralda; Brouwer, Kimberly C.; Hogg, Robert S.; Patterson, Thomas L.; Lozada, Remedios; Magis-Rodriguez, Carlos; Elder, John P.; Viani, Rolando M.; Strathdee, Steffanie A.

2010-01-01

416

Inauguracin del portal "Venezuela" de la Biblioteca Virtual Alicante, 15 de noviembre de 2001  

E-print Network

sociales. Estamos sin duda en la era del conocimiento, en la sociedad del conocimiento, cada cuatro años se uso de técnicas de tiempo compartido, redes de comunicaciones, junto con la alta capacidad de beneficios sociales. Todos estos avances son impensables sin los computadores, ellos permiten diseñar

Escolano, Francisco

417

ETICA EN ENFERMERÍA Y SU RELACIÓN CON EL PODER Y ORGANIZACIÓN DEL TRABAJO  

Microsoft Academic Search

4 Las dificultades enfrentadas en el cotidiano del trabajo de enfermería, en especial en hospitales han sido denunciadas, sin embargo las implicancias éticas resultantes no están siendo enfocadas o por lo menos discutidas a nivel de los trabajadores ni de los clientes. La organización del trabajo puede constituirse en una mayor fuente de sufrimiento para los trabajadores de enfermería, lo

Valéria Lerch Lunardi; Michele Salum Bulhosa

418

Liberi di respirare Sensori innovativi per misurare la concentrazione del gas Radon  

E-print Network

Liberi di respirare Sensori innovativi per misurare la concentrazione del gas Radon ® #12;RSens si occupa della progettazione, produzione e vendita di sensori innovativi per la misura del gas Radon: un sia per prestazioni che per flessibilità di utilizzo. La societàLa società #12;Che cos'è Il Radon è un

419

rgano informativo del Colegio de Ciencias y Humanidades Nmero 2, 9 de abril de 2007  

E-print Network

Suplemento especial �rgano informativo del Colegio de Ciencias y Humanidades Número 2, 9 de abril en docencia, quienes en el futuro tendrán a su cargo las labores docentes del Colegio de Ciencias y Ciencias y Humanidades, a fin de que éste sea ágil, transparente y salvaguarde los legítimos derechos de

Islas, León

420

Visite el sitio Web del Instituto de Ciencia Regional, donde encontrar informacin  

E-print Network

Visite el sitio Web del Instituto de Ciencia Regional, donde encontrará información detallada Instituto de Ciencia Regional Estado de actualización: Junio del 2005 Universität Karlsruhe (TH) Instituto de Ciencia Regional Programa acreditado de Master ,,Ciencia regional/ Planificaión territorial

Snelting, Gregor

421

Facultad de Filosofa y Letras CTS del Grado CIENCIAS Y LENGUAS DE LA ANTIGEDAD  

E-print Network

Facultad de Filosofía y Letras CTS del Grado CIENCIAS Y LENGUAS DE LA ANTIG�EDAD UNIVERSIDAD AUT�NOMA DE MADRID TRABAJO DE FIN DE GRADO EN CIENCIAS Y LENGUAS DE LA ANTIG�EDAD DIRECTRICES PROPIAS Aprobado por la CTS del grado en Ciencias y Lenguas de la Antigüedad Aprobado por los Consejos de los

Autonoma de Madrid, Universidad

422

2 marzo 2008 [TEMPO TRA FISICA E FILOSOFIA] Alcuni Aspetti del Tempo tra Fisica e Filosofia  

E-print Network

2 marzo 2008 [TEMPO TRA FISICA E FILOSOFIA] Alcuni Aspetti del Tempo tra Fisica e Filosofia ­ Istituto Nazionale di Astrofisica Associato di ricerca ­ Istituto Nazionale di Fisica Nucleare 1 di speculazione filosofica, la natura fisica del tempo, la sua intima essenza, lo stesso significato

Longo, Giuseppe

423

Aspectos generales de la Red Nacional de Estudios Clínicos del NCI  

Cancer.gov

Reseña general sobre la estructura organizativa de la Red Nacional de Estudios Clínicos del NCI, así como un resumen de los cambios que se están llevando a cabo y una sinopsis de cómo estos cambios se basan en el éxito del programa de Grupos Cooperativos.

424

Examen del estado Mini-Mental: propuesta de una normativa para su aplicación  

Microsoft Academic Search

Resumen. El examen del estado Mini-Mental (EEMM) es actualmente una de las herramientas más influyentes en la valoración y búsqueda de alteraciones cognitivas, aun a pesar de determinados interrogantes con respecto a su validez. Aunque se ha generalizado la utilización informal de varias traducciones del EEMM en lengua castellana, al no haberse validado éstas ni estar apenas especificada su aplicación

S. Giménez-Roldán; M. J. Novillo; E. Navarro; J. L. Dobato; M. Giménez-Zuccarelli

425

DERECHOS DE LOS EMPLEADOS SEGN LA LEY NACIONAL DE RELACIONES DEL TRABAJO  

E-print Network

DERECHOS DE LOS EMPLEADOS SEG�N LA LEY NACIONAL DE RELACIONES DEL TRABAJO La Ley Nacional de Relaciones del Trabajo (LNRT) garantiza el derecho de los empleados a organizarse y negociar colectivamente empleadores y sindicatos. En este Aviso encontrará información general sobre sus derechos y las obligaciones

426

JORNADA SOBRE LA TRANSFORMACIN DEL DERECHO PRIVADO ANTE LA CRISIS1  

E-print Network

JORNADA SOBRE LA TRANSFORMACI�N DEL DERECHO PRIVADO ANTE LA CRISIS1 . Lugar de celebración: Sala Conde. Catedrático de D. Constitucional y Director del Instituto de Derecho Público. URJC. 10:00 Conferencia inaugural Prof. Dr. D. Domingo Bello Janeiro, Catedrático de Derecho Civil. Universidad de

Rey Juan Carlos, Universidad

427

Más allá del contemporáneo: Mondo Bizzarro Gallery y la teoría de un Arte Hipercontemporáneo  

Microsoft Academic Search

El siguiente texto pretende plantear la paradoja existente en la ciudad de Roma respecto a su condición de ciudad-capital italiana y la ausencia de exposiciones de arte contemporáneo a nivel museal. Partiendo del acercamiento a una posible definición de “lo contemporáneo” se pretende dilucidar su estrecha relación con el campo del arte. Un nuevo espacio expositivo en la escena romana,

Paulina C. Pinto Paganini

2011-01-01

428

Violación del Principio de Equivalencia en Teorías con Dilatón de Cuerdas  

Microsoft Academic Search

Se estudian las violaciones al Principio de Equivalencia en Teorías con Dilatón de Cuerdas. En estos modelos, algunas de las constantes fundamentales dependen del espacio y del tiempo. Se muestra que los experimentos de caída libre no tienen aún precisión como para poner límites a los parámetros de la teoría.

S. J. Landau; P. D. Sisterna; H. Vucetich

2003-01-01

429

78 FR 52716 - Proposed Amendment of Class E Airspace; Del Rio, TX  

Federal Register 2010, 2011, 2012, 2013, 2014

...new circling approach requirements at Laughlin Air Force Base (AFB). The FAA is taking...extension to a Class C surface area at Laughlin AFB, Del Rio, TX. An additional segment...it would amend controlled airspace at Laughlin AFB, Del Rio, TX. Environmental...

2013-08-26

430

Padova, 27 febbraio 2013 SUONA LA CAMPANELLA PER LA SCHOLA DEL BO  

E-print Network

Padova, 27 febbraio 2013 SUONA LA CAMPANELLA PER LA SCHOLA DEL BO SABATO PRIMA LEZIONE CON UMBERTO CURI Iniziano sabato 2 marzo con una lezione del filosofo Umberto Curi gli appuntamenti de "La Schola scientificamente da Saveria Chemotti, Umberto Curi, Walter Pisent e Giorgio Tinazzi che intende proporre a tutta la

Schenato, Luca

431

Investigacin Centro de Investigacin y de Estudios Avanzados del Instituto Politcnico Nacional  

E-print Network

Nacional Unidad Mérida Recursos del Mar Investigador Línea de Investigación Luz María Dalila Aldana Aranda, fitoplancton, pastos marinos y manglares. Jesús Ernesto Arias González Ecología del paisaje, conectividad

432

Panorama reflexivo sobre el teatro de grupo en el Perú en la década del 80  

E-print Network

SPRING 1992 137 Panorama reflexivo sobre el teatro de grupo en el Perú en la década del 80 Domingo Piga L Introducción El desarrollo social, económico y político del Perú en los últimos 25 años, determinó cambios fundamentales en el teatro...

Piga, Domingo

1992-04-01

433

Consejo Asesor del Decanato de Estudios Tecnolgicos Acta 11-2011 Pg. 1 de 4 UNIVERSIDAD SIMON BOLIVAR  

E-print Network

extraplanes de Estudios Generales, Prof. Otilia Rosa- Coordinadora del Ciclo Profesional. 6. Homologación de palabra a la Prof. Otilia Rosas en representación del Decanato de Estudios Generales (DEG), quien hace

Vásquez, Carlos

434

Misión Madres Del Barrio: A Bolivarian Social Program Recognizing Housework and Creating A Caring Economy in Venezuela  

E-print Network

ABSTRACT: This thesis began as a project about Misión Madres del Barrio; and it quickly transformed into a glimpse of the Bolivarian Revolution underway in Venezuela. Misión Madres del Barrio (MMB) is one of the pioneering social programs...

Fischer-Hoffman, Cory

2008-08-20

435

78 FR 6173 - Diana Del Grosso, Ray Smith, Joseph Hatch, Cheryl Hatch, Kathleen Kelley, Andrew Wilklund, and...  

Federal Register 2010, 2011, 2012, 2013, 2014

...Transportation Board [Docket No. FD 35652] Diana Del Grosso, Ray Smith, Joseph Hatch, Cheryl Hatch, Kathleen Kelley, Andrew...to a petition filed on August 1, 2012, by Diana Del Grosso, Ray Smith, Joseph Hatch, Cheryl Hatch, Kathleen Kelley,...

2013-01-29

436

High carrier frequency of the 35delG deafness mutation in European populations. Genetic Analysis Consortium of GJB2 35delG.  

PubMed

Congenital deafness accounts for about 1 in 1000 infants and approximately 80% of cases are inherited as an autosomal recessive trait. Recently, it has been demonstrated that connexin 26 (GJB2) gene is a major gene for congenital sensorineural deafness. A single mutation (named 35delG) was found in most recessive families and sporadic cases of congenital deafness, among Caucasoids, with relative frequencies ranging from 28% to 63%. We present here the analysis of the 35delG mutation in 3270 random controls from 17 European countries. We have detected a carrier frequency for 35delG of 1 in 35 in southern Europe and 1 in 79 in central and northern Europe. In addition, 35delG was detected in five out of 376 Jewish subjects of different origin, but was absent in other non-European populations. The study suggests either a single origin for 35delG somewhere in Europe or in the Middle East, and the possible presence of a carrier advantage together with a founder effect. The 35delG carrier frequency of 1 in 51 in the overall European population clearly indicates that this genetic alteration is a major mutation for autosomal recessive deafness in Caucasoids. This finding should facilitate diagnosis of congenital deafness and allow early treatment of the affected subjects. PMID:10713883

Gasparini, P; Rabionet, R; Barbujani, G; Melçhionda, S; Petersen, M; Brøndum-Nielsen, K; Metspalu, A; Oitmaa, E; Pisano, M; Fortina, P; Zelante, L; Estivill, X

2000-01-01

437

El Instituto de Ciencias del Mar y Limnologa, organiza el "Da Mundial del Agua 2012", un evento de Puertas Abiertas para celebrar "El Agua y la seguridad alimentara" tema  

E-print Network

El Instituto de Ciencias del Mar y Limnología, organiza el "Día Mundial del Agua 2012", un evento AYALA-CASTA�ARES" INSTITUTO DE CIENCIAS DEL MAR Y LIMNOLOGÍA, UNAM PROGRAMA 09:30 - 09:35 Inauguración y

Islas, León

438

Disruption of cytokeratin-8 interaction with F508del-CFTR corrects its functional defect  

PubMed Central

We have previously reported an increased expression of cytokeratins 8/18 (K8/K18) in cells expressing the F508del mutation of cystic fibrosis transmembrane conductance regulator (CFTR). This is associated with increased colocalization of CFTR and K18 in the vicinity of the endoplasmic reticulum, although this is reversed by treating cells with curcumin, resulting in the rescue of F508del-CFTR. In the present work, we hypothesized that (i) the K8/K18 network may interact physically with CFTR, and that (ii) this interaction may modify CFTR function. CFTR was immunoprecipitated from HeLa cells transfected with either wild-type (WT) CFTR or F508del-CFTR. Precipitates were subjected to 2D-gel electrophoresis and differential spots identified by mass spectrometry. K8 and K18 were found significantly increased in F508del-CFTR precipitates. Using surface plasmon resonance, we demonstrate that K8, but not K18, binds directly and preferentially to the F508del over the WT human NBD1 (nucleotide-binding domain-1). In vivo K8 interaction with F508del-CFTR was confirmed by proximity ligation assay in HeLa cells and in primary cultures of human respiratory epithelial cells. Ablation of K8 expression by siRNA in F508del-expressing HeLa cells led to the recovery of CFTR-dependent iodide efflux. Moreover, F508del-expressing mice topically treated with K8-siRNA showed restored nasal potential difference, equivalent to that of WT mice. These results show that disruption of F508del-CFTR and K8 interaction leads to the correction of the F508del-CFTR processing defect, suggesting a novel potential therapeutic target in CF. PMID:22038833

Colas, Julien; Faure, Grazyna; Saussereau, Emilie; Trudel, Stéphanie; Rabeh, Wael M.; Bitam, Sara; Guerrera, Ida Chiara; Fritsch, Janine; Sermet-Gaudelus, Isabelle; Davezac, Noëlie; Brouillard, Franck; Lukacs, Gergely L.; Herrmann, Harald; Ollero, Mario; Edelman, Aleksander

2012-01-01

439

Fundacin General de la UIB (FuGUIB) La Fundacin General de la Universidad de las Illes Balears (FuGUIB) es una institucin privada,  

E-print Network

de 51 personas equivalentes a tiempo completo, 61% mujeres. La FuGUIB cerró el ejercicio económico el curso 2012-13 han sido las siguientes: renovación del mobiliario en las zonas comunes y las habitaciones, reposición del suelo de los pasillos y zonas comunes, cambio del grupo de presión para el agua

Oro, Daniel

440

Assessing Glacier Hazards At Ghiacciaio Del Belvedere, Macugnaga, Italian Alps  

NASA Astrophysics Data System (ADS)

The uppermost section of the Valle Anzasca behind and above the community of Macugnaga in the Italian Alps is one of the most spectacular high-mountain land- scapes in Europe, with gigantic rock walls and numerous steep hanging glaciers. Its main glacier, Ghiacciaio del Belvedere at the foot of the huge Monte Rosa east face, is a heavily debris-covered glacier flowing on a thick sediment bed. Problems with floods, avalanches and debris flows from this ice body have been known for extended time periods. Most recently, however, the evolution of this highly dynamic environ- ment has become more dramatic. An outburst of Lago delle Locce, an ice-dammed lake at the confluenec of the tributary Ghiacciaio delle Locce with Ghiacciaio del Belvedere, caused heavy damage in 1979 and necessitated site investigation and con- struction work to be done for flood protection. The intermittent glacier growth ten- dency in the 1970es induced strong bulging of the glacier surface and, in places, caused the glacier tongue to override historical morains and to destroy newly-grown forest stands. A surge-type flow acceleration started in the lower parts of the Monte- Rosa east face during summer 2000, leading to strong crevassing and deformation of Ghiacciaio del Belvedere and extreme bulging of its orographic right margin. High water pressure and accelerated movement lasted into winter 2001/2002: the ice now started overriding the LIA moraine near Rifugio Zamboni of the CAI. In addition but rather independently, a most active detachment zone for rock falls and debris flows developed for several years now in the east face of Monte Rosa, somewhat more to the south of the accelerated glacier movement and at an altitude where relatively warm permafrost must be expected. Besides the scientific interest in these phenomena, the growing hazard potential to the local infrastructure must be considered seriously. Es- pecially potentials for the destabilization of large rock and ice masses in the east face of Monte Rosa, for interruption of the access trail to the Rifugio Zamboni by overrid- ing and/or collapse of the lateral moraine, for impacts by ice invading various instal- lations (cable car, restaurant, ski runs, trails) near the moraine hill of Belvedere, and for sudden outbursts of pressurized subglacial water or the newly formed supraglacial lake must be envisaged.

Haeberli, W.; Chiarle, M.; Mortara, G.; Mazza, A.

441

La educación en España: indicadores del gasto en educación y comparación con los países de la UE  

Microsoft Academic Search

La educación es uno de los bienes que el sector público produce y producirá, porque además de tener características de bien público tiene externalidades, es un bien preferente y es un instrumento redistribuidor de riqueza. La eficiencia exigible al sector público precisa del estudio de las condiciones de provisión del bien. En concreto del conocimiento de los factores de los

1994-01-01

442

Comparacion internacional del gasto publico en sanidad y educacion en paises de la OCDE 85-90  

Microsoft Academic Search

En este trabajo trataremos de analizar el nivel del gasto publico en España comparandolo con otros paises europeos y de la OCDE, para ello nos centraremos en dos partidas fundamentales del gasto como son la sanidad y la educacion, ya que estos dos tipos de gasto son fundamentales para el bienestar ciudadano y asi mismo son indicativos del nivel asistencial

Ana Iglesias; Isabel Neira

1995-01-01

443

Impacto de las Tecnologías de la Información y las Comunicaciones (TIC) en el desarrollo y la competitividad del país  

Microsoft Academic Search

La primera parte de este estudio caracteriza al sector de telecomunicaciones en Colombia, comparando a Colombia con otros países y regiones del mundo, mostrando la evolución de algunos de los principales indicadores de telecomunicaciones. En la segunda parte se hacen estimaciones cuantitativas del impacto socioeconómico del sector en la economía colombiana, a través de dos herramientas: la metodología insumo-producto y

Juan Benavides; Felipe Castro; Lina Devis; Mauricio Olivera

2011-01-01

444

MASTER ENEA Modulo 1 Fisica del Plasma. Confinamento Magnetico Lecture 11 1 Instabilities and transport in burning plasmas  

E-print Network

MASTER ENEA Modulo 1 Fisica del Plasma. Confinamento Magnetico Lecture 11 ­ 1 Lecture 11" University of Rome, MASTER ENEA Modulo 1 Fisica del Plasma. Confinamento Magnetico 20­28 March 2013 Fulvio Zonca #12;MASTER ENEA Modulo 1 Fisica del Plasma. Confinamento Magnetico Lecture 11 ­ 2 Lecture Plan

Zonca, Fulvio

445

FESTIVAL INTERNACIONAL D'ARQUITECTURA EME3_2011 Del 30 de junio al 3 de Julio 201  

E-print Network

FESTIVAL INTERNACIONAL D'ARQUITECTURA EME3_2011 Del 30 de junio al 3 de Julio 201 INFORMACI� PER ALS VOLUNTARIS Llocs Col.legi d'Arquitectes de Catalunya (COAC) Arts Santa Mònica Disseny HUB muntatge i desmuntatge de l'exposició en les 4 seus Dates: muntatge del 27/06 al 30/06 desmuntatge del 3

Geffner, Hector

446

75 FR 44720 - Safety Zone; Live-Fire Gun Exercise, M/V Del Monte, James River, VA  

Federal Register 2010, 2011, 2012, 2013, 2014

...Safety Zone; Live-Fire Gun Exercise, M/V Del Monte, James River, VA AGENCY...a temporary safety zone encompassing the M/V Del Monte. This safety zone will restrict...Reserve Fleet within a 1500 foot radius of the M/V Del Monte. This action is intended...

2010-07-29

447

Near-IR Photometry of Nova Del 2013  

NASA Astrophysics Data System (ADS)

Subjects: Infra-Red, Nova We report Near-IR photometry of Nova Del 2013 taken with the 0.76-m infrared telescope at the University of Minnesota's O'Brien Observatory (Marine on St. Croix, Minnesota, USA). RIJHKLM photometry were obtained on August 21.17 and 23.13 UT using an AsSi bolometer. Vega (alpha Lyrae) was used as the standard star. Our photometry show: August 21.17 UT: R = 5.1 +/- 0.1, I = 4.6 +/- 0.1, J = 4.6 +/- 0.1, H = 4.1 +/- 0.1, K = 3.9 +/- 0.1, L = 2.7 +/- 0.2, M = +2.2 +/- 0.2.

Cass, C. A.; Carlon, L. R.; Corgan, T. D.; Dykhoff, A. D.; Gehrz, D. R.; Shenoy, P. D.

2013-08-01

448

Ozone studies in the Paso del Norte region  

NASA Astrophysics Data System (ADS)

The Paso del Norte region forms the largest contiguous bi-national conglomerate on the US-Mexico border. With a combined population of around 2 million inhabitants, the Paso del Norte region is isolated, more than 500 km away from the nearest urban area of comparable size, thus making it an ideal location for air quality studies of an isolated urban environment. The meteorological conditions leading to a high ozone episode in this region, such as the historical ozone episode of June 2006, are analyzed. It is well known that stagnation and minimal winds, high temperatures, and pressure ridges over the region are conducive to high ozone episodes. In addition, the planetary boundary height is studied to understand its impact on high ozone episodes. Several studies report that ground level ozone non-attainment regulations could be caused not only by local emissions, but also by atmospheric transport. In this work the atmospheric advection of pollutants into the region is analyzed using HYSPLIT backward trajectories. Furthermore, a novel backward trajectory clustering technique is implemented for the summer of 2006. The "ozone weekend effect" (OWE) is a phenomenon by which in some geographical regions ambient ozone concentrations tend to be higher on weekends than on weekdays, despite the lower emissions of ozone precursors during those days. The observed local OWE has never previously been studied in terms of the photolysis rates of four of the main ozone precursors. In this research a novel method that allows the calculation of actinic fluxes, photolysis frequencies and photolysis rates with a high degree of accuracy and reliability has been developed. This method utilizes a combination of the experimental data available for this region in conjunction with a radiative transfer model (TUV model). Three weekend-weekday cases during summers 2006, 2009 and 2010 are studied in this work. In this research, the photolysis impact on the local OWE is studied. The results obtained from this photolysis study demonstrate that the local ground level ozone formation is not only influenced by the strong solar radiation and changing aerosol makeup, but also by other heterogeneous factors and reactions. In addition, this research provided good evidence that the ground level ozone precursor regime in El Paso during the ozone episode of June 2006 was mostly VOC-limited. Much of this estimation was derived from measurements of local ambient VOC/NOx ratios. This finding shows that at least during June 2006, the non-linear surface ozone production increased during weekends compared to workdays in a habitually VOC-limited regime. The seasonal variations of columnar ozone as measured by a Multi-filter Rotating Shadowband instrument installed at the UTEP campus are analyzed for the first time for this region and results are presented. This investigation has addressed the problem of ground-level ozone formation in the Paso del Norte region. Urban ozone is a complex problem with many aspects that are not fully understood. In this investigation, a range of techniques has been used to address the study of local surface ozone episodes with the purpose of acquiring new insights and knowledge that will help understand and remediate the diverse atmospheric pollution events that affect this bi-national region recurrently. Innovative techniques were developed and used, ranging from the use of local ambient atmospheric pollution data to the utilization of complex modeling techniques to achieve the best possible computer results. Finally, the influence of ground level ozone concentrations in admissions to hospitals for this region due to respiratory diseases is analyzed. The comprehensive results obtained in this work will help to better understand ozone formation in the Paso del Norte Region for future policy regulation implementations.

Becerra-Davila, Fernando

449

Taphonomy of guanaco bones in Tierra del Fuego  

NASA Astrophysics Data System (ADS)

Guanaco carcasses are deposited in great quantities in Cabo San Pablo, Tierra del Fuego (Argentina), as a result of winter stress. Taphonomic studies indicate that the gnawing action of foxes on guanaco ( Lama guanicoe) carcasses produces only very tenuous marks on the bones. Lack of sustained interest in the carcasses by carnivores results in slow disarticulation. The articulated and disarticulated bones are exposed to heavy trampling by guanacos, a process that produces vertical migration of small/dense bones and fracturing of the most weathered bones. An understanding of this ongoing process is important for local archaeology, since modern bones are migrating into archaeological contexts. A regional approach to taphonomy is the most appropriate instrument to solve this and other related problems.

Borrero, Luis Alberto

1990-11-01

450

Deglacial palaeoclimate at Puerto del Hambre, subantarctic Patagonia, Chile  

NASA Astrophysics Data System (ADS)

The primary objective of this study is to further substantiate multistep climatic forcing of late-glacial vegetation in southern South America. A secondary objective is to establish the age of deglaciation in Estrecho de Magallanes-Bahía Inútil. Pollen assemblages at 2-cm intervals in a core of the mire at Puerto del Hambre (53°3621S, 70°5553W) provide the basis for reconstructing the vegetation and a detailed account of palaeoclimate in subantarctic Patagonia. Chronology over the 262-cm length of core is regulated by 20 AMS radiocarbon dates between 14 455 and 10 089 14C yr BP. Of 13 pollen assemblage zones, the earliest representing the Oldest Dryas chronozone (14 455-13 000 14C yr BP) records impoverished steppe with decreasing frequencies and loss of southern beech (Nothofagus). Successive 100-yr-long episodes of grass/herbs and of heath (Empetrum/Ericaceae) before 14 000 14C yr BP infer deglacial successional communities under a climate of increased continentality prior to the establishment of grass-dominated steppe. The Bølling-Allerød (13 000-11 000 14C yr BP) is characterised by mesic grassland under moderating climate that with abrupt change to heath dominance after 12 000 14C yr BP was warmer and not as humid. At the time of the Younger Dryas (11 000-10 000 14C yr BP), grass steppe expanded with a return of colder, more humid climate. Later, with gradual warming, communities were invaded by southern beech. The Puerto del Hambre record parallels multistep, deglacial palaeoclimatic sequences reported elsewhere in the Southern Andes and at Taylor Dome in Antarctica. Deglaciation of Estrecho de Magallanes-Bahía Inútil is dated close to 14 455 14C yr BP, invalidating earlier dates of between 15 800 and 16 590 14C yr BP.

Heusser, Calvin J.; Heusser, Linda E.; Lowell, Thomas V.; Moreira M., Andrés; Moreira M., Simón

2000-02-01

451

EL PROTEOMA DEL TEJIDO ADIPOSO SUBCUTÁNEO MUESTRA HETEROGENEIDAD ANATÓMICA  

PubMed Central

Introducción El tejido adiposo blanco (TAB) subcutáneo (Sc) humano podría variar dependiendo de su localización anatómica, con diferencias en su perfil proteómico. Pacientes y métodos Se obtuvieron aspirados de TAB-Sc de seis mujeres con IMC >25 kg/m2, sometidas a liposucción. Dicho TAB-Sc se obtuvo de seis localizaciones anatómicas: abdominal superior e inferior, muslo, dorsal, flanco y cadera, analizándose su perfil proteómico mediante electroforesis bidimensional. En muslo y abdomen superior se compararon, además, las muestras obtenidas de las dos capas del TAB-Sc (profunda y superficial). Resultados Se detectaron 21 proteínas que mostraban una intensidad de expresión diferente entre las seis localizaciones anatómicas y 14 entre las capas superficial y profunda de una misma región. Entre las proteínas identificadas se incluyen: vimentina (proteína estructural); proteínas “heat-shock” (HSPs), superóxido-dismutasa, (estrés/chaperoninas); proteína fijadora de ácidos grasos 4 (FABP-4) y alfa-enolasa (metabolismo lipídico y de los hidratos de carbono, respectivamente) y ATP-sintetasa (producción de energía). Entre las regiones estudiadas, el TAB-Sc dorsal mostraba un perfil proteómico particular, con menor expresión de proteínas implicadas en la producción de energía y metabolismo (ATP-sintetasa, alfa-enolasa, HSPs y FABP-4) que el resto de regiones. Conclusiones Los niveles de expresión de diversas proteínas en el TAB-Sc humano no son homogéneos, difiriendo entre localizaciones anatómicas. Esto sugiere la existencia de diferencias funcionales en el TAB-Sc de acuerdo con su localización anatómica, lo que debe considerarse antes de asumir la extrapolación de los datos derivados del TAB-Sc de una determinada localización al de otras partes de la anatomía. PMID:23228439

Martos-Moreno, G.A.; Sackmann-Sala, L.; Berryman, D.E.; Blome, D.W.; Argente, J.; Kopchick, y J.J.

2015-01-01

452

RASTREO DEL CANCER COLORRECTAL CONOCIMIENTO Y ACTITUD DE LA POBLACION  

PubMed Central

Resumen El rastreo de cáncer colorrectal (CCR) cuenta con fuertes evidencias en su favor. Datos preliminares indican que a pesar de ello no se lleva a cabo con la frecuencia adecuada. Se intenta aquí determinar, dentro de un Sistema de Salud que cuenta con los recursos necesarios, los elementos que facilitan o generan barreras para concretar esta práctica preventiva, cuántos individuos lo ponen en práctica y qué predice esta conducta. Se realizó una encuesta telefónica a los afiliados de una Obra Social de empleados de la Universidad de Buenos Aires, de los que 132 completaron el cuestionario (tasa de respuesta 70%). Los elementos considerados facilitadores del rastreo obtuvieron respuestas afirmativas en el 64 a 97%, mientras que los que definían barreras un 11 a 27%. En este último grupo, una categoría diferenciada la constituía el miedo a los efectos adversos: 39%, y el sentimiento de vergüenza relacionado con los procedimientos: 30%. Un 33% de los encuestados tenían hecho un método de rastreo, mayoritariamente de sangre oculta (27), sigmoideoscopía (11) y colonoscopía (20). Una mayoría afirmó que “se haría el procedimiento si el médico se lo recomendara” (95%), o “no se lo haría excepto que su médico se lo aconseje” (87%). Contestar afirmativamente que “los médicos hacen lo mejor para los pacientes” se asoció con haberse hecho un método de rastreo de CCR, OR 1.55 (IC 95%: 1.02-2.37) p: 0.04. El grupo de individuos estudiado parece bien predispuesto para el rastreo del CCR, la recomendación médica sería aquí un determinante prominente para ponerlo en práctica. PMID:19414294

CASAL, ENRIQUE R.; VELAZQUEZ, ELIZABETH N.; MEJIA, RAUL M.; CUNEO, ALDO; PEREZ-STABLE, ELISEO J.

2014-01-01

453

Quaternary eruptive history of Nevado del Ruiz (Colombia)  

NASA Astrophysics Data System (ADS)

Nevado del Ruiz has a 1.8-m.y.-long eruptive record that includes alternate construction and destruction of three edifices during three main eruptive periods, termed "ancestral Ruiz", "older Ruiz" and "Ruiz". Nevado del Ruiz is located on a complex intersection of four groups of faults, the most significant being the N20° E Palestina strike-slip fault and the N50° W Villamaria-Termales normal fault. Ancestral Ruiz was a broad stratovolcano built by two eruptive stages of lava flows starting about 1.8 Ma ago and ending 1.0 Ma ago. A partial collapse and formation of a caldera are thought to have occurred between 1.0 and 0.8 Ma ago. Older Ruiz was a stratovolcano constructed by lava flows in three stages starting about 0.8 Ma ago and ending about 0.2 Ma ago. Extensive and voluminous welded and nonwelded pyroclastic-flow deposits that partly fill preexisting valleys record the formation of a young summit caldera between 0.2 and 0.15 Ma ago. Present Ruiz is formed by a cluster of composite lava domes that probably filled the summit caldera of older Ruiz. Present Ruiz eruptive activity is mostly explosive, but also includes dome growth, and parasitic dome activity of La Olleta and Alto La Piramide. Twelve eruptive stages occurred during the last 11,000 years, accompanied by rockslide-debris avalanches, pyroclastic flows or surges, and their subsequent interactions with the ice cap, as well as by glacial erosion and mass-wasting. Diverse processes within these twelve stages have led to a partial destruction of the summit domes. This long and complex Pleistocene and Holocene eruptive sequence helps to put the November 13, 1985, eruption into a broader perspective.

Thouret, J.-C.; Cantagrel, J. M.; Salinas, R.; Murcia, A.

1990-07-01

454

Spatial shell structure of the novas DQ Her and HR Del  

SciTech Connect

This paper considers the formation of the spatial shell structure of the novas DQ Her (1934) and HR Del (1967). It is shown that the existence of polar caps is due to the influence of the second component of the system on the angular distribution of the mass shell depth of the mainshell. The ratio of the mass shell depth in the equatorial ring and in the polar caps is 1.13 for DQ Her and 2.7 for HR Del. The ratio of the maximal densities in the equatorial ring and the polar caps is of order 3 for DQ Her and of order 70 for HR Del.

Pilyogin, L.S.

1986-03-01

455

Metodología para el estudio de mercado de los productos de importación agrícolas, pecuarios y sus transformados en el sector emergente del municipio Holguín  

Microsoft Academic Search

El proceso de revitalización del sector productivo en el municipio de Holguín se inició el 27 de Mayo del 2007, a partir de las orientaciones de las autoridades del territorio sobre el mismo. Teniendo como referencia los cuatros elementos básicos a desarrollar tales como el incremento de las exportaciones, disminución de las Importaciones, elevación de la productividad del trabajo y

Gelmar García Vidal; Mirna Lázara González Velázquez

2011-01-01

456

Centro vital Jueves, 04 de Septiembre de 2014 09:51  

E-print Network

Centro vital Jueves, 04 de Septiembre de 2014 09:51 {ifactumpie pie=5171} Recuperación Centro Tradicional de Bogotá. El foco de intervención es una zona que cubre un territorio de 471 como la protección del patrimonio cultural, mantenimiento de la diversidad de la zona, la permanencia

Amézquita, Adolfo

457

ForPeerReview Rodent middens reveal episodic, long-distance plant  

E-print Network

of Ecology & Biodiversity Maldonado, Antonio; Centro de Estudios Avanzados en Zonas Aridas, Laboratorio de Estudios Avanzados en Zonas Áridas (CEAZA), Colina del Pino s/n, La Serena, Chile (4) Dirección de 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 #12;ForPeerReview 2 ABSTRACT Aim To document

458

SEMANA 9: del 02 al 06 de Junio de 2014 COMEDOR MyS  

E-print Network

Frutas (1 vaso) Pizca andina (1 taza) Asado negro (120 g) Arroz verde (150 g) Ens. Cocida de calabacin del mercado; estos cambios no alteran el balance nutricional de los menues LUNES MARTES MIERCOLES

Vásquez, Carlos

459

HAER DEL,3MILF.V,2 (sheet 1 of 4) Mispillion Lighthouse, South ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

HAER DEL,3-MILF.V,2- (sheet 1 of 4) - Mispillion Lighthouse, South bank of Mispillion River at its confluence with Delaware River at northeast end of County Road 203, 7 miles east of Milford, Milford, Sussex County, DE

460

HAER DEL,3MILF.V,2 (sheet 3 of 4) Mispillion Lighthouse, South ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

HAER DEL,3-MILF.V,2- (sheet 3 of 4) - Mispillion Lighthouse, South bank of Mispillion River at its confluence with Delaware River at northeast end of County Road 203, 7 miles east of Milford, Milford, Sussex County, DE

461

HAER DEL,3MILF.V,2 (sheet 4 of 4) Mispillion Lighthouse, South ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

HAER DEL,3-MILF.V,2- (sheet 4 of 4) - Mispillion Lighthouse, South bank of Mispillion River at its confluence with Delaware River at northeast end of County Road 203, 7 miles east of Milford, Milford, Sussex County, DE

462

HAER DEL,3MILF.V,2 (sheet 2 of 4) Mispillion Lighthouse, South ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

HAER DEL,3-MILF.V,2- (sheet 2 of 4) - Mispillion Lighthouse, South bank of Mispillion River at its confluence with Delaware River at northeast end of County Road 203, 7 miles east of Milford, Milford, Sussex County, DE

463

Un Atlas Digital muy a la mexicana Medicin de parmetros meteorolgicos: Globo Cautivo del CCA  

E-print Network

Comisión Nacional del Agua (CONAGUA), en un proyecto conjunto entre el SMN y la Unidad de Informática para la falta de lluvias; sin embargo, existen factores que contribuyen a ella, como alteraciones en la

Grutter, Michel

464

Exploración del Sistema Solar -- Una mirada hacia el futuro - Duration: 0:30.  

NASA Video Gallery

¿Piensas que ya sabemos todo acerca de nuestro sistema solar? La realidad es que apenas hemos comenzado con lo que hay para conocer. Únete a la NASA, en el envío de misiones a los confines del sist...

465

Exploración del Nuevo Laboratorio Científico de Marte - Duration: 2:51.  

NASA Video Gallery

Únase a Fernando Abilleira, un analista de trayectoria de la NASA para la Oficina de Exploración de Marte, y conozca las nuevas tecnologías que el nuevo robot Curiosity del Laboratorio Científico d...

466

DeaLing with Ontologies using CODs Chiara Del Vescovo1  

E-print Network

DeaLing with Ontologies using CODs Chiara Del Vescovo1 and Rafael Pe~naloza2 1 School of Computer the Context-Oriented Decomposition (COD) of an ontology as a technique that combines the benefits of both

Baader, Franz

467

Calcio y la prevención del cáncer: solidez y límites de la evidencia científica  

Cancer.gov

Hoja informativa que resume los resultados de estudios sobre el calcio y la prevención del cáncer. Incluye información sobre las recomendaciones dietéticas para calcio y la cantidad de calcio en los alimentos y en complementos de calcio.

468

Observers for a Class of Hybrid Systems on a Domitilla Del Vecchio and Richard M. Murray  

E-print Network

Observers for a Class of Hybrid Systems on a Lattice Domitilla Del Vecchio and Richard M. Murray amounts of computation. Caines [2] shows that the complexity of the observer often arises from the need

Murray, Richard M.

469

STABLE PAIR, TROPICAL, AND LOG CANONICAL COMPACT MODULI SPACES OF DEL PEZZO SURFACES  

E-print Network

STABLE PAIR, TROPICAL, AND LOG CANONICAL COMPACT MODULI SPACES OF DEL PEZZO SURFACES PAUL HACKING compactification. 1 #12;2 PAUL HACKING, SEAN KEEL, AND JENIA TEVELEV 1.2. Theorem. The variety Y n is log minimal

Tevelev, Jenia

470

Ciclo de muda y reproducción de la población del langostino Pleoticus muelleri (Crustacea, Penaeoidea) de Mar del Plata Molting cycle and reproduction in the population of the shrimp Pleoticus muelleri (Crustacea, Penaeoidea) from Mar del Plata  

Microsoft Academic Search

The relationship between the molting cycle and gonadal maturation was investigated in the Pleoticus muelleri population from coastal waters of Mar del Plata, Argentina. The analysis of the molting activity revealed activity patterns that vary conspicuously with both the changes in shrimp reproductive status and the season. Males and females exhibited a molt synchronism and the intermolt lengthened during the

Ana Cristina Díaz; Ana María Petriella; Jorge L. Fenucci; CIC Pcia

471

MONITOR DE PILATES B1. Bases biomdicas del Pilates (15 HORAS).  

E-print Network

, Especialista en Medicina de la EF y el Deporte, Doctor en Medicina, Experto en Fisiología del Ejercicio Ramón Heredia Ldo. Ciencias de la Actividad Física y el Deporte, Especialista en Salud y práctica Especialista en Acondicionamiento Físico en Sala Musculación. Miembro Honor Federación Medicina del Deporte R

Escolano, Francisco

472

NCI ofrece apoyo a quienes están necesitados después del huracane Katrina  

Cancer.gov

El Instituto Nacional del Cáncer (NCI), parte de los Institutos Nacionales de la Salud (NIH), está empeñado en ayudar a las miles de personas que han sido asoladas por los efectos del huracán Katrina. NCI está tratando de llegar a los públicos diversos para proporcionarles información relacionada con el cáncer que pueda ser compartida con exactitud y efectividad con quienes han sido afectados por el huracán.

473

GENE POOL -El juego de cartas del ADN por Mark Goadrich  

E-print Network

GENE POOL - El juego de cartas del ADN por Mark Goadrich http://games.goadrich.com Instrucciones 2 de pares de bases de vuestra mano, para modificar y reordenar una secuencia de ADN común. Sólo investigación actual) y sólo la revelaréis cuando hayais conseguido la secuencia de ADN correcta. A lo largo del

Goadrich, Mark

474

Las Escrituras del Margen. En Torno a los Territorios Canónicos de la Literatura Latinoamericana  

E-print Network

resto de la producción literaria de su tiempo, constituyéndose junto con otras pocas, en los referentes ineludibles de la época y contextos que les dieron origen. Su presencia se vuelve parte del paisaje cultural no sólo de su propia época sino de la... la categoría de obras clásicas. De entre ellas algunas se vuelven canónicas. Desafortunada o quizá en algunos casos, afortunadamente1, gran parte del resto de la producción literaria termina, desvalorándose, desvaneciéndose y finalmente olvidándose...

Ayarza-Riveros, Luis Carlos

2013-12-09

475

Flujomultfaseenlacelda16delCabril Flujo multifases en la celda 16 de "El Cabril"  

E-print Network

Caudal(ml/día) 0 20 40 60 80 100 Lluvia(mm/día) Caudal Luvia #12;Flujomultfaseenlacelda16delCabril La causa ¿Lluvia entra por las juntas de hormigón? #12;Flujomultfaseenlacelda16delCabril Otra hipótesis, verano Evaporación Condensación Flujo difusivo de vapor Escorrentía Flujo de agua líquida hacia el

Politècnica de Catalunya, Universitat

476

Semirido: un desafo para la CienciaSemirido: un desafo para la Ciencia del Suelodel Suelo  

E-print Network

mostró mayor espesor y correspondió a aportes de lluvia. La composición isotópica del agua extraída del(SL), Argentina ISOTOPOS ESTABLES COMO TRAZADORES DE LAS FUENTES DE AGUA DE BOSQUES DE ALGARROBO EN UN DESIERTO. Biology ­ Duke University, Durham, North Carolina (27708), EE.UU. RESUMEN: El agua subterránea puede ser

Nacional de San Luis, Universidad

477

Elaphopsocoides, a new genus of Psocidae (Psocodea: ´Psocoptera´) from Valle del Cauca, Colombia.  

PubMed

Two new species of Elaphopsocoides n. gen. from Valle del Cauca, Colombia, are here described and illustrated. The new genus is related to Elaphopsocus Roesler, but differs from it mostly in the hypandrial projections and in phallosome structure. The female subgenital plate has a distinct, median, posterior projection. The types are deposited in the Entomology Museum, Universidad del Valle (MUSENUV), Santiago de Cali, Colombia. PMID:25544209

Román-P, Cristian; Aldrete, Alfonso N García; Obando, Ranulfo González

2014-01-01

478

Facultad de Ciencias Polticas y Sociales Datos del plan de estudio  

E-print Network

Facultad de Ciencias Políticas y Sociales Datos del plan de estudio Nombre del idioma: Francés Dirigido a: egresados de licenciatura de la Facultad de Ciencias Políticas y Sociales. Síntesis o carreras de Ciencias Políticas y Sociales. -100 por ciento de créditos -Dos fotografías tamaño credencial

Islas, León

479

Juvenile rheumatoid arthritis and del(22q11) syndrome: a non-random association  

Microsoft Academic Search

Del(22q11) is a common microdeletion syndrome with an extremely variable phenotype. Besides classical manifestations, such as velocardiofacial (Shprintzen) or DiGeorge syndromes, del(22q11) syndrome may be associated with unusual but probably causally related anomalies that expand its phenotype and complicate its recognition. We report here three children with the deletion and a chronic, erosive polyarthritis resembling idiopathic cases of juvenile rheumatoid

A Verloes; C Curry; M Jamar; C Herens; P OLague; J Marks; P Sarda; P Blanchet

1998-01-01

480

On embeddings of universal torsors over del Pezzo surfaces in cones over flag varieties  

NASA Astrophysics Data System (ADS)

Following Skorobogatov and Serganova, we construct embeddings of universal torsors over del Pezzo surfaces in cones over flag varieties regarded as closed orbits in the projectivizations of quasi-miniscule representations. Our approach enables us to construct embeddings of universal torsors over del Pezzo surfaces of degree 1. This approach uses the notion of Mumford stability and differs slightly from that of the authors named above.

Zhgoon, Vladimir S.

2010-10-01

481

Impact of Observing Parameters on 17 Nights with Nova Del 2013 (Abstract)  

NASA Astrophysics Data System (ADS)

(Abstract only) Nova Del 2013 (V339 Del) was reported in Astronomer’s Telegram No. 5279 (PNV 20233073+2046041) on 2013 August 14. On the following day, the University of Colorado, Boulder, granted our observing request for use of the R3000-5000 spectrograph attached to their 60-cm telescope. The planning, operational approach, analysis techniques, results, issues, and operational conclusions for data taken from 15 August through 2 September are reported here.

Green, W. L.

2014-12-01

482

Protesi di ginocchio a stabilizzazione posteriore e a conservazione del legamento crociato posteriore. Esame comparativo  

Microsoft Academic Search

L’artroprotesi totale di ginocchio si è oramai dimostrata un presidio efficace nel ridurre l’entità del dolore ed incrementare\\u000a le capacità funzionali. Dati ottenuti da studi eseguiti sia su artroprotesi postero-stabilizzate (PS) che su quelle a conservazione\\u000a del crociato posteriore (PCR) hanno messo in evidenza risultati rilevanti anche a lungo termine. Ancora oggi esiste, tuttavia,\\u000a notevole controversia su quale sia il

G. Cerulli; A. Caraffa; P. Antinolfi; G. Zamarra

483

Se inicia estudio de los NIH sobre respuestas excepcionales al tratamiento del cáncer  

Cancer.gov

La Iniciativa de Respuestas Excepcionales (Exceptional Responders Initiative), un estudio que investiga los factores moleculares de los tumores en pacientes de cáncer que responden en forma excepcional al tratamiento con medicamentos, se inició hoy bajo la guía del Instituto Nacional del Cáncer (NCI). Los científicos tratarán de identificar en los tumores las características moleculares que predicen si un medicamento o una clase de medicamento en particular será beneficioso o no.

484

Alonso Quijano en el Callejón del Gato: Las ficciones de psycho-killers españolas  

E-print Network

cuando era niño en la novela negra, Alfred Hitchcock y Vázquez Montalbán. 6 Índice Introducción: Esquizofrenia y violencia en la cultura herida ……………………………………………………. 7 El precio de una snuff movie: Globalización y espectáculo en las... máximo exponente. Los resultados de la aceptación de estos valores se manifiestan de un modo más evidente en el uso de las snuff movies como símbolo principal del valor mercantil adquirido por la imagen violenta en la cultura herida y el uso del cuerpo...

Meijide Lapido, Arturo Francisco

2010-04-23

485

Paso del Norte ozone study VOC measurements, 1996  

SciTech Connect

The results of VOC determinations of ambient air samples collected at surface air quality monitoring sites and near sources of interest on the US and Mexican side of the border during six weeks of the 1996 Paso del Norte Ozone Study are reported. Carbonyl samples were collected on DNPH impregnated cartridges at three surface sites and analyzed by HPLC to quantify 13, C-1 to C-8 species. Whole air samples were collected in electro-polished stainless steel canisters which were returned to laboratory for determination of C-2 to C-10+ hydrocarbons by cryogenic preconcentration capillary gas chromatography with flame ionization detection (gc-fid). Several sources were sampled: rush hour traffic, propane-powered bus exhaust, automobile paint shop emissions, propane fuel, petroleum refinery, and industrial manufacturing site. Spatial and temporal characteristics of VOC species concentrations and compositions are presented. Overall surface TNMOC values ranged from 0.1 to 3.4 ppmC with the highest concentrations recorded in the morning at three vehicle-dominated sites, two in Cuidad Juarez and one in downtown El Paso. Toluene in El Paso samples and propane, which is used as a cooking and transportation fuel in Cuidad Juarez, were the most abundant hydrocarbons.

Seila, R.L.; Main, H.; Arriaga, J.L.; Martinez, G.V.; Ramadan, A.B.

1999-01-01

486

Paso del Norte ozone study VOC measurements, 1996  

SciTech Connect

The results of VOC determinations of ambient air samples collected at surface air quality monitoring sites and near sources of interest on the US and Mexican side of the border during six weeks of the 1996 Paso del Norte Ozone Study are reported. Carbonyl samples were collected on DNPH impregnated cartridges at three surface sites and analyzed by HPLC to quantify 13, C-1 to C-8 species. Whole air samples were collected in electro-polished stainless steel canisters which were returned to laboratory for determination of C-2 to C-10+ hydrocarbons by cryogenic preconcentration capillary gas chromatography with flame ionization detection (gc-fid). Several sources were sampled: rush hour traffic, propane-powered bus exhaust, automobile paint shop emissions, propane fuel, petroleum refinery, and industrial manufacturing site. Spatial and temporal characteristics of VOC species concentrations and compositions are presented. Overall surface TNMOC values ranged from 0.1 to 3.4 ppmC with the highest concentrations recorded in the morning at three vehicle-dominated sites, two in Cuidad Juarez and one in downtown El Paso. Toluene in El Paso samples and propane, which is used as a cooking and transportation fuel in Cuidad Juarez, were the most abundant hydrocarbons.

Seila, R.L.; Main, H.; Arriaga, J.L.; Martinez, G.V.; Ramadan, A.B.

1999-11-01

487

Seismicity following the 1985 eruption of Nevado del Ruiz, Colombia  

USGS Publications Warehouse

Over 200 of the best-recorded earthquakes occurring near Nevado del Ruiz, Colombia, between December 1985 and May 1986 are examined for spatial patterns, information on local stress orientations, and evidence for seismogenic structures that may be related to magma-transport processes. These earthquakes occurred following the devastating eruption of November 13, 1985. Earthquake activity that is probably related to the volcanic system occurs over a large area, of the order of 50 km2. A pattern of earthquakes beneath the southern half of Ruiz may be the expression of a conduit system, but evidence is inconclusive due to low spatial resolution of most hypocenters. Epicenter and first-motion plots suggest most earthquakes occur on small faults of varying orientation. Most seismicity during this time period was unrelated to mapped faults, including some with Holocene offsets, except for the Villamaria Fault near Ruiz's northeast sector. Composite focal mechanisms show a variation of nearly 90?? in the strike of T-axes and indicate Ruiz is in a zone of local extension. ?? 1990.

Zollweg, J.E.

1990-01-01

488

``Campo del Cielo'' Meteorites: Astronomical Heritage and Cultural Colonialism  

NASA Astrophysics Data System (ADS)

In the province of Chaco, Argentina, there is a very unique dispersion of metallic meteorites called ``Campo del Cielo''. One of the meteoric fragments of this dispersion, the meteorite called ``El Chaco'', consisting of 37 tons, is the second heaviest in the world. These meteorites are of great importance to the worldview of the Moqoit, aboriginal people that inhabit this region. For the local Creole population the meteorites are also relevant, that's why they have being cited in numerous documents and reports since the colonial period. During the first months of 2012, two Argentine artists and the Artistic Director of the German contemporary art exhibition called dOCUMENTA (13) tried to move ``El Chaco'' meteorite to Germany in order to exhibit it as an artistic object. Due to the fact that moving the meteorite could have a negative impact according to the Moqoit cosmology and that they were not able to participate in the decision they begun a manifestation against the movement of El Chaco. The opposition made by aboriginal communities and experts in cultural astronomy was able to stop the transfer. The whole process and its impact on the local community have promoted a deep discussion about art, science and cultural colonialism. In this paper we aim to address this debate and its consequences. This will allow us to think about contemporary forms of colonialism that are hidden in many scientific and artistic projects. Furthermore, we aim to debate about the most effective ways of protecting astronomical heritage in the Third World.

López, Alejandro Martín; Altman, Agustina

2012-09-01

489

Malaria vectors in San José del Guaviare, Orinoquia, Colombia.  

PubMed

This study was conducted to determine Anopheles species composition and their natural infectivity by human Plasmodium in 2 localities with the highest malaria transmission in San Jose del Guaviare, Guaviare, Colombia. A total of 1,009 Anopheles mosquitoes were collected using human landing catches during 8 months in 2010. Anopheles darlingi was the most abundant (83.2%) followed by An. albitarsis s.l. (8.6%), Anopheles braziliensis (3.8%), An. oswaldoi s.l. (1%), and An. rangeli (0.3%). Anopheles darlingi showed the highest human biting rate, and it was found naturally infected with Plasmodium vivax VK210 (0.119%) using enzyme-linked immunosorbent assays. All species were collected biting both indoors and outdoors. Anopheles darlingi showed biting activity overnight with an indoor peak between 1200-0100 h. Therefore, we recommend that malaria prevention strategies focus on 1) insecticide-treated nets to reduce human-vector contact when people are most exposed and unprotected; 2) accurate diagnoses; 3) adequate treatment for patients; 4) more timely epidemiological notification; and 5) improved entomological surveillance. PMID:25102591

Jiménez, Irene P; Conn, Jan E; Brochero, Helena

2014-06-01

490

Mini-mastoidectomía para anastomosis hipogloso-facial con sección parcial del nervio hipogloso  

PubMed Central

Introducción: La anastomosis hipogloso-facial es la técnica de elección para la reparación de la parálisis facial cuando no se dispone de un cabo proximal sano del nervio facial. La técnica de anastomosis mediante fresado mastoideo y sección parcial del hipogloso minimiza la atrofia lingual sin sacrificar resultados a nivel facial. Método: La porción mastoidea del nervio facial transcurre por la pared anterior de la AM, a un promedio de 18+/-3 mm de profundidad respecto de la pared lateral. Se debe reconocer la cresta supramastoidea, desde la cual se marca una línea vertical paralela al eje mayor de la AM, 1 cm por detrás de la pared posterior del CAE El fresado se comienza desde la línea medio mastoidea hasta la pared posterior del CAE. Una vez encontrado el nervio facial en el tercio medio del canal mastoideo, el mismo es seguido hacia proximal y distal. Resultados: El abordaje descripto permite acceder al nervio facial intratemporal en su porción mastoidea, y efectuar un fresado óseo sin poner en riesgo al nervio o a estructuras vasculares cercanas. Se trata de un procedimiento técnicamente más sencillo que los abordajes amplios habitualmente utilizados al hueso temporal; no obstante su uso debe ser restringido mayormente a la anastomosis hipogloso-facial. Conclusión: Esta es una técnica relativamente sencilla, que puede ser reproducida por cirujanos sin mayor experiencia en el tema, luego de su paso por el laboratorio de anatomía. PMID:23596555

Campero, Álvaro; Ajler, Pablo; Socolovsky, Mariano; Martins, Carolina; Rhoton, Albert

2012-01-01

491

Evaluación de la utilidad diagnóstica de la versión española del cuestionario al informador «AD8»?  

PubMed Central

Introducción El AD8 es un cuestionario al informador breve que puede ser autoaplicado y facilita la identificación de deterioro cognitivo (DC); nuestro objetivo es evaluar la utilidad diagnóstica (UD) de una versión española. Material y métodos Estudio transversal en una muestra clínica de díadas paciente/ informador, 330 sujetos con sospecha de DC o demencia (DEM) y 71 controles. Se ha evaluado la consistencia interna (? de Cronbach) y la validez (correlaciones parciales con estadio GDS, Fototest e índice funcional [IF]). La UD se ha evaluado para no DC vs DC (GDS 3–4) por medio del área bajo la curva ROC (aROC) y se ha considerado mejor punto de corte aquel que hacía máximo el índice de Youden. Resultados En la muestra, 105 no tenían DC, 99 tenían DC sin DEM y 203 DEM. La consistencia interna es alta (? 0,90, IC del 95%, 0,89–0,92), al igual que las correlaciones con GDS (r = 0,72, p < 0,001), Fototest (r = ?0,61, p < 0,001) e IF (r = 0,59, p < 0,001). El aROC del AD8 es 0,90 (IC del 95%, 0,86–0,93), sin diferencia significativa con la del Fototest (aROC 0,93, IC del 95%, 0,89–0,96); el mejor punto de corte es 3/4 con sensibilidad de 0,93 (IC del 95%, 0,88–0,96), especificidad de 0,81 (IC del 95%, 0,72–0,88) y el 88,8% de las clasificaciones correctas. El uso conjunto de AD8 y Fototest mejora de forma significativa la UD de ambos (aROC 0,96, IC del 95%, 0,93–0,98, p < 0,05). Conclusiones La versión española del AD8 conserva las cualidades psicométricas y la UD de la versión original; su uso combinado con el Fototest mejora de forma significativa la UD de ambos. PMID:22652137

Pardo, C. Carnero; de la Vega Cotarelo, R.; Alcalde, S. López; Aparicio, C. Martos; Carrillo, R. Vílchez; Gavilán, E. Mora; Galvin, J.E.

2012-01-01

492

Caracterización y selección del lugar de nidificación de la grulla cubana (Grus canadensis nesiotes) en los herbazales del Refugio de Fauna El Venero, Cuba  

Microsoft Academic Search

Grus canadensis nesiotes es una subespecie endémica y amenazada de grulla cuyas poblaciones están asociadas a humedales de agua dulce. En este trabajo se caracterizó su lugar de nidificación y se determinó su selección a tres escalas espaciales en los herbazales del Refugio de Fauna El Venero, Cuba, durante los años 2005–2007. Se monitorizaron 26 nidos hasta la eclosión. También

Y. Ferrer Sánchez; D. Denis Ávila; I. Ruiz Companioni

2010-01-01

493

Transformacin del campus para el desarrollo de un modelo social integral y su interaccin con el entorno territorial Tabla I. Descripcin de las actuaciones del proyecto  

E-print Network

, promociones entre los estudiantes y presencia activa en los actos de graduación, newsletters, redes sociales yTransformación del campus para el desarrollo de un modelo social integral y su interacción con el colectivo de referencia en los ámbitos de ciencias sociales, de la comunicación y de la biomedicina

Geffner, Hector

494

LAS FLECHAS EN EL ARTE LEVANTINO: APORTACIONES DESDE EL ANÁLISIS DE LOS PROYECTILES DEL REGISTRO ARQUEOLÓGICO DEL RIU DE LES COVES (ALT MAESTRAT, CASTELLÓ )  

Microsoft Academic Search

RESUMEN: En el presente trabajo se aborda el estudio de las flechas en el Arte Levantino a partir de su contrastación con los proyectiles en piedra tallada recuperados en los yacimientos meso- líticos y neolíticos más próximos a los abrigos pintados del núcleo de la Valltorta-Gasulla. El aná- lisis de las diferentes modalidades de representación y las distintas propuestas de

Javier FERNÁNDEZ LÓPEZ DE PABLO

495

Screening for F508del as a first step in the molecular diagnosis of cystic fibrosis*,**  

PubMed Central

OBJECTIVE: To determine the relevance of screening for the F508del mutation of the cystic fibrosis transmembrane conductance regulator gene as a first step in the genetic diagnosis of cystic fibrosis (CF) by associating the genotype with various clinical variables. METHODS: We evaluated 180 CF patients regarding the F508del mutation. The clinical data were obtained from the medical records of the patients and from interviews with their parents or legal guardians. RESULTS: Of the 180 patients studied, 65 (36.1%) did not carry the F508del mutation (group 0 [G0]), 67 (37.2%) were F508del heterozygous (G1), and 48 (26.7%) were F508del homozygous (G2). All three groups showed associations with the clinical variables. Homozygosis was associated with younger patients, younger age at CF diagnosis, and younger age at the first isolation of Pseudomonas aeruginosa (PA), as well as with higher prevalence of pancreatic insufficiency (PI) and non-mucoid PA (NMPA) colonization. In comparison with G1+G2 patients, G0 patients were older; first experienced clinical symptoms, digestive disease, and pulmonary disease at an older age; were older at CF diagnosis and at first PA isolation; and had a lower prevalence of PI and meconium ileus, as well as of colonization by NMPA, mucoid PA, and Burkholderia cepacia. In G1 patients, values were intermediate for age at CF diagnosis; age at first PA isolation, first pulmonary symptoms, and first clinical manifestations; MPA colonization; and OR for PI. CONCLUSIONS: The identification of F508del in 63.9% of the patients studied showed that this can be a useful tool as a first step in the genetic diagnosis of CF. The F508del genotype was associated with clinical severity of the disease, especially with the variables related to CF onset. PMID:23857699

Marson, Fernando Augusto de Lima; Bertuzzo, Carmen Silvia; Ribeiro, Maria Ângela Gonçalves de Oliveira; Ribeiro, Antônio Fernando; Ribeiro, José Dirceu

2013-01-01

496

VIP-dependent increase in F508del-CFTR membrane localization is mediated by PKC?.  

PubMed

The most common cystic fibrosis causing mutation F508del induces early degradation and reduced trafficking of cystic fibrosis transmembrane conductance regulator (CFTR) chloride channels to the apical membrane of epithelial cells. In the human nasal epithelial cells JME/CF15, we previously reported that vasoactive intestinal peptide (VIP) exposure corrects trafficking and membrane insertion of functional F508del-CFTR channels at 37°C. Correction of trafficking was PKA dependent, whereas enhanced membrane localization involved PKC. In the present study, we have identified PKC? as the isoform involved in VIP-dependent F508del-CFTR membrane insertion. Iodide effluxes were used to monitor the presence of VIP-rescued functional F508del-CFTR channels at the surface of JME/CF15 cells maintained at 37°C. Iodide efflux peaks measured in response to stimulation with forskolin were insensitive to PKC ?, ?, ?, ?, ? inhibitors. In contrast, efflux peaks were completely inhibited by pretreatment with the PKC? inhibitor peptide EAVSLKPT with an IC(50) of 4.9 ?M or by PKC? small interfering RNA (siRNA). Immunostaining and confocal microscopy confirmed that membrane localization of F508del-CFTR induced by VIP was abolished in the presence of EAVSLKPT but not with other isoform inhibitors. In recombinant baby hamster kidney cells, endogenously expressing PKC? but no VIP receptor, wild-type, and F508del-CFTR sensitivity to cpt-cAMP stimulation was increased by PMA treatment. Biotinylation assays and immunoblots confirmed that PMA (0.5-2 h) induced a greater than threefold increase in membrane CFTR, whereas forskolin had no effect. The PMA effect was abolished by specifically inhibiting PKC? (EAVSLKPT IC(50) = 5.7 ?M) but not other PKC isoforms. Taken together, these results indicate that stimulating PKC? by VIP or PMA increases membrane insertion and activity of WT- and F508del-CFTR. PMID:21411725

Alcolado, Nicole; Conrad, Dustin J; Rafferty, Sara; Chappe, Frédéric G; Chappe, Valérie M

2011-07-01

497

TABLA DE ADAPTACIONES DE ASIGNATURAS SUPERADAS EN EL PROGRAMA SIMULTNEO DERECHO-ADE POR LAS ASIGNATURAS DEL GRADO DE DERECHO  

E-print Network

TABLA DE ADAPTACIONES DE ASIGNATURAS SUPERADAS EN EL PROGRAMA SIMULTÁNEO DERECHO-ADE POR LAS ASIGNATURAS DEL GRADO DE DERECHO 1º CURSO DERECHO Créditos Tipo DERECHO-ADE Créditos Tipo Derecho Romano 6 FB Derecho Romano 6 FB Historia del Derecho Español y de las Instituciones 6 FB Historia del Derecho Español

Escolano, Francisco

498

Accidentes en plantas nucleares de electricidad y el riesgo de cáncer  

Cancer.gov

Hoja informativa acerca de los riesgos del cáncer asociados con accidentes en plantas nucleares de electricidad. Incluye información para pacientes con cáncer que viven en una zona que puede haber sido afectada por un accidente en una planta nuclear.

499

[Radiological percutaneous gastrostomy (grp), 17 años de experiencia, serie de casos del hospital universitario virgen del rocío].  

PubMed

When assessing a patient nutritional support the state of the gastrointestinal tract is the most important point to consider, whenever possible we should choose the enteral nutrition (EN) over parenteral nutrition (PN) and recognized by its various advantages. The percutaneous gastrostomy (GRP) were introduced in clinical practice as an alternative to surgical gastrostomy (GQ). The speed, simplicity, low cost, low morbidity and low mortality of these techniques has allowed its rapid development.The feeding tubes types used were the balloon-retained devices catheter, the pig tail and the ballon-retained with gastropexia (gastropexia). It is a retrospective study of all patients who were placed GPR in the Virgen del Rocío University Hospital, Sevilla, between September 1996 and September 2013, which aims to study is to describe the characteristics of patients and the complications presented for different types of enteral feeding tubes used. GPR 186 were performed in 176 patients (135 males (76.70%), with an average duration of 303.6 days, the most frequent diseases were cancers of the head and neck 49.46%. The types of feeding tubes used were pigtail 118 (63.44%), balloon-retained devices 22 (11.83%), and gastropexia 46 (24.73%). The most common early complications in the pigtail group were early purulent exudate and early bleeding (2.5 and 3.4% respectively), while in the balloon catheter group the initial output of the probe was most frequent early complication (13.7%), none of these complications were observed in the group of gastropexy. The most common late complication was obstruction probe. The GPR is a safe technique with lower mortality of 1%; Low frequently of early and late complications. A better understanding of this technique can reduce the frequency of complications. PMID:25561125

Navarro Falcón, Magnolia Del Carmen; Parejo Campos, Juana; Pereira Cunill, José Luis; García Luna, Pedro Pablo

2015-01-01

500

The RGD finger of Del-1 is a unique structural feature critical for integrin binding  

SciTech Connect

Developmental endothelial cell locus-1 (Del-1) glycoprotein is secreted by endothelial cells and a subset of macrophages. Del-1 plays a regulatory role in vascular remodeling and functions in innate immunity through interaction with integrin {alpha}{sub V}{beta}{sub 3}. Del-1 contains 3 epidermal growth factor (EGF)-like repeats and 2 discoidin-like domains. An Arg-Gly-Asp (RGD) motif in the second EGF domain (EGF2) mediates adhesion by endothelial cells and phagocytes. We report the crystal structure of its 3 EGF domains. The RGD motif of EGF2 forms a type II' {beta} turn at the tip of a long protruding loop, dubbed the RGD finger. Whereas EGF2 and EGF3 constitute a rigid rod via an interdomain calcium ion binding site, the long linker between EGF1 and EGF2 lends considerable flexibility to EGF1. Two unique O-linked glycans and 1 N-linked glycan locate to the opposite side of EGF2 from the RGD motif. These structural features favor integrin binding of the RGD finger. Mutagenesis data confirm the importance of having the RGD motif at the tip of the RGD finger. A database search for EGF domain sequences shows that this RGD finger is likely an evolutionary insertion and unique to the EGF domain of Del-1 and its homologue milk fat globule-EGF 8. The RGD finger of Del-1 is a unique structural feature critical for integrin binding.

Schürpf, Thomas; Chen, Qiang; Liu, Jin-huan; Wang, Rui; Springer, Timothy A.; Wang, Jia-huai (Harvard-Med)

2012-11-13