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Sample records for 002d 002d 002d

  1. Effects of a Combined Therapy With D-002 (Beeswax Alcohols) Plus D-003 (Sugarcane Wax Acids) on Osteoarthritis Symptoms.

    PubMed

    Puente, Roberto Antonio; Illnait, José; Mas, Rosa María; Carbajal, Daisy María; Mendoza, Sarahí; Ceballos, Alfredo; Fernández, Julio César; Mesa, Meilis; Reyes, Pablo; Ruiz, Dalmer

    2016-06-01

    Context • Nonsteroidal, anti-inflammatory drugs effectively relieve osteoarthritis (OA) symptoms but also induce adverse effects (AEs) that limit their long-term use, which drives a search for safer treatments. D-002, a mixture of beeswax alcohols, and D-003, a mixture of sugarcane wax acids, have been effective in experimental and clinical studies for patients with OA. Objective • The study intended to investigate the effects on OA symptoms of a combined therapy using D-002 and D-003 (D-002/D-003), which were administered for 6 wk. Design • The study was a randomized, double-blind, placebo-controlled trial. Setting • The study was conducted at the Surgical Medical Research Center in Havana, Cuba. Participants • Participants were patients with mild-to-moderate OA. Intervention • Participants were randomly assigned to 1 of 4 groups-(1) a control group, which received a placebo; (2) the D-002 group (intervention group), which received 50 mg/d of D-002; (3) the D-003 group (intervention group), which received 10 mg/d of D-003; or (4) the D-002/D-003 group (intervention group), which received a combined therapy of 50 mg/d of D-002 plus 10 mg/d of D-003. The control group received tablets that were indistinguishable in appearance from the D-002 and D-003 tablets and had a similar composition, except that the active ingredients were replaced by lactose. The groups took the medications once per day for 6 wk. Outcome Measures • Symptoms were assessed using the Western Ontario and McMaster Individual Osteoarthritis Index (WOMAC) and a visual analogue scale (VAS). The primary outcome was the reduction in the total WOMAC score. The subscale scores on the WOMAC for pain, stiffness, and physical function, the VAS scores, and the use of rescue medications were secondary outcomes. Results • Of the 120 enrolled participants, 116 completed the study. The treatments with D-002, D-003, and D-002/D-003 reduced the mean total WOMAC scores significantly from baseline to

  2. Sub-Doppler Stark Spectroscopy in the A−X (1,0) Band of CN

    SciTech Connect

    Hall, G.E.; Hause, M.L.; Sears, T.J.

    2009-11-26

    The effect of external electric fields has been measured in hyperfine-resolved sub-Doppler transitions in the A {sup 2}{Pi}-X {sup 2}{Sigma} (1,0) band of the CN radical near 10900 cm{sup -1}. Static electric fields less than 1 kV/cm are sufficient to mix the most closely spaced {Lambda}-dpublets in the A state, leading to Stark spectra with both new and shifted resonances. Simulations of the saturation-dip Stark spectral line profiles allow extraction of the A-state permanent electric dipole moment with a magnitude of 0.06 {+-} 0.02 D.

  3. Temperature dependence of light power propagation in bending plastic optical fiber

    NASA Astrophysics Data System (ADS)

    Jing, Ning; Teng, Chuanxin; Zheng, Jie; Wang, Guanjun; Zhang, Minjuan; Wang, Zhibin

    2016-09-01

    This study investigates the effect of temperature variation on the light power propagation in bending plastic optical fiber (POF). The transmittance of bending POFs with curvature radius of 2-30 mm and turns of 1/4, 1/2, 1, and 2 are measured over temperature of 20-70 °C. The temperature dependent loss of the bending POF is obtained. It is found that the temperature dependent loss of the bending POF changes with curvature radius and turns. The temperature effect reaches the highest value of 0.011 dB/°C with 2 turns, and is less than 0.002 dB/°C with curvature radius greater than 25 mm.

  4. Thin-ribbon tapered coupler for dielectric waveguides

    NASA Technical Reports Server (NTRS)

    Yeh, C.; Otoshi, T. Y.; Shimabukuro, F. I.

    1994-01-01

    A recent discovery shows that a high-dielectric constant, low-loss, solid material can be made into a ribbon-like waveguide structure to yield an attenuation constant of less than 0.02 dB/m for single-mode guidance of millimeter/submillimeter waves. One of the crucial components that must be invented in order to guarantee the low-loss utilization of this dielectric-waveguide guiding system is the excitation coupler. The traditional tapered-to-a-point coupler for a dielectric rod waveguide fails when the dielectric constant of the dielectric waveguide is large. This article presents a new way to design a low-loss coupler for a high- or low-dielectric constant dielectric waveguide for millimeter or submillimeter waves.

  5. Reflective all-fiber magnetic field sensor based on microfiber and magnetic fluid.

    PubMed

    Luo, Longfeng; Pu, Shengli; Tang, Jiali; Zeng, Xianglong; Lahoubi, Mahieddine

    2015-07-13

    A kind of reflective all-fiber magnetic field sensor based on a non-adiabatically tapered microfiber with magnetic fluid is proposed and experimentally demonstrated. The modal interference effect is caused by the abrupt tapers, which result in an approximately sinusoidal spectral response. The reflection spectra of the proposed sensor under different magnetic field strengths have been measured and theoretically analyzed. The maximum sensitivity of 174.4 pm/Oe is achieved at wavelength of around 1511 nm. Besides, an intensity tunability of -0.02 dB/Oe is also achieved. Comparing with the traditional sensors operating at transmission mode, the presented sensor in this work owns the advantages of smaller size and higher sensitivity and resolution due to the enhanced extinction ratio. The proposed structure is also promising for designing other tunable all-in-fiber photonic devices.

  6. Digital test signal generation: An accurate SNR calibration approach for the DSN

    NASA Technical Reports Server (NTRS)

    Gutierrez-Luaces, B. O.

    1991-01-01

    A new method of generating analog test signals with accurate signal to noise ratios (SNRs) is described. High accuracy will be obtained by simultaneous generation of digital noise and signal spectra at a given baseband or bandpass limited bandwidth. The digital synthesis will provide a test signal embedded in noise with the statistical properties of a stationary random process. Accuracy will only be dependent on test integration time with a limit imposed by the system quantization noise (expected to be 0.02 dB). Setability will be approximately 0.1 dB. The first digital SNR generator to provide baseband test signals is being built and will be available in early 1991.

  7. Determination of the degree of substitution of sodium carboxymethylcellulose by potentiometric titration and use of the extended henderson-hasselbalch equation and the simplex method for the evaluation.

    PubMed

    Aggeryd, I; Olin, A

    1985-08-01

    Determination of the degree of substitution, D.S., of purified sodium carboxymethylcellulose, CMC, by potentiometric titration has been studied. Different mathematical descriptions of the acid-base properties of polyelectrolytes were tested on the titration curve. It was found that the extended Henderson-Hasselbalch equation reproduced the measured data well. It was therefore used as a basis for evaluating D.S. by the simplex method. The influence of ionic strength, I, on the shape of the titration curve was investigated and the effect of I on the precision of the titrations was evaluated. The titrations showed a precision of +/- 0.004 D.S.-units and the results were in agreement with those obtained from a dry-ashing method, within +/- 0.02 D.S.-units. The whole method, including preparation of solutions and titration, showed a precision of +/- 0.01 D.S.-units.

  8. A THz heterodyne instrument for biomedical imaging applications

    NASA Technical Reports Server (NTRS)

    Siegel, Peter H.

    2004-01-01

    An ultra-wide-dynamic-range heterodyne imaging system operating at 2.5 THz is described. The instrument employs room temperature Schottky barrier diode mixers and far infrared gas laser sources developed for NASA space applications. A dynamic range of over 100dB at fixed intermediate frequencies has been realized. Amplitude/phase tracking circuitry results in stability of 0.02 dB and +-2 degrees of phase. The system is being employed to characterize biological (human and animal derived tissues) and a variety of materials of interest to NASA. This talk will describe the instrument and some of the early imaging experiments on everything from mouse tail to aerogel.

  9. The Effects of Gravity on ZBLAN Glass

    NASA Technical Reports Server (NTRS)

    Tucker, Dennis S.; Workman, Gary; Smith, Guy; Tucker, Dennis S.

    1999-01-01

    Heavy metal fluoride glass fibers show promise in applications such as surgical lasers, spectroscopy and imaging fiber bundles. ZBLAN, which is within this class has been studied for a number of years. ZBLAN's theoretical attenuation coefficient is approximately 0.002 dB/km which is much better than that of fused silica at 0.2 dB/km. However, due to impurities and crystallites the attenuation coefficients achieved to date are considerably larger than those of fused silica. Impurities can be controlled with better processing techniques. Crystallization has been found to be a function of gravity. It is found that heating to the crystallization temperature in unit gravity results in crystallization while heating in reduced gravity does not. The exact mechanism for this phenomenon is not known but is speculated to be related to stress.

  10. Quantum-limited operation of balanced mixer homodyne and heterodyne receivers

    NASA Astrophysics Data System (ADS)

    Machida, Susumu; Yamamoto, Yoshihisa

    1986-05-01

    In the GaAs semiconductor laser balanced mixer heterodyne receiver of Abbas and Chan (1983), the photocurrent fluctuation due to local oscillator wave intensity noise was suppressed, but the absolute quantum noise level calibration was not clarified. In this paper, the results of experimental calibration of the quantum noise level were obtained using two different methods: photocurrent spectral density measurement and photoelectron counting. The noise of a balanced mixer operation was confirmed to be truly quantum limited; the photocurrent fluctuation spectral density measured with a spectrum analyzer agreed with the quantum noise spectral density. The deviations from the absolute quantum noise level were within + or -0.02 dB. Complete suppression of local oscillator excess noise was demonstrated in the 0-1.5 GHz frequency region. Uses of balanced mixers for observing the squeezing phenomenon and quantum nondemolition measurement is mentioned.

  11. Ultrabroadband polarization splitter based on three-core photonic crystal fiber with a modulation core.

    PubMed

    Zhao, Tongtong; Lou, Shuqin; Wang, Xin; Zhou, Min; Lian, Zhenggang

    2016-08-10

    We design an ultrabroadband polarization splitter based on three-core photonic crystal fiber (PCF). A modulation core and two fluorine-doped cores are introduced to achieve an ultrawide bandwidth. The properties of three-core PCF are modeled by using the full-vector finite element method along with the full-vector beam propagation method. Numerical results demonstrate that an ultrabroadband splitter with 320 nm bandwidth with an extinction ratio as low as -20  dB can be achieved by using 52.8 mm long three-core PCF. This splitter also has high compatibility with standard single-mode fibers as the input and output ports due to low splicing loss of 0.02 dB. All the air holes in the proposed structure are circular holes and arranged in a triangular lattice that makes it easy to fabricate. PMID:27534489

  12. Structures and Nuclear Quadrupole Coupling Tensors of a Series of Chlorine-Containing Hydrocarbons

    NASA Astrophysics Data System (ADS)

    Dikkumbura, Asela S.; Webster, Erica R.; Dorris, Rachel E.; Peebles, Rebecca A.; Peebles, Sean A.; Seifert, Nathan A.; Pate, Brooks

    2016-06-01

    Rotational spectra for gauche-1,2-dichloroethane (12DCE), gauche-1-chloro-2-fluoroethane (1C2FE) and both anti- and gauche-2,3-dichloropropene (23DCP) have been observed using chirped-pulse Fourier-transform microwave (FTMW) spectroscopy in the 6-18 GHz region. Although the anti conformers for all three species are predicted to be more stable than the gauche forms, they are nonpolar (12DCE) or nearly nonpolar (predicted dipole components for anti-1C2FE: μ_a = 0.11 D, μ_b = 0.02 D and for anti-23DCP: μ_a = 0.25 D, μ_b = 0.02 D); nevertheless, it was also possible to observe and assign the spectrum of anti-23DCP. Assignments of parent spectra and 37Cl and 13C substituted isotopologues utilized predictions at the MP2/6-311++G(2d,2p) level and Pickett's SPCAT/SPFIT programs. For the weak anti-23DCP spectra, additional measurements also utilized a resonant-cavity FTMW spectrometer. Full chlorine nuclear quadrupole coupling tensors for gauche-12DCE and both anti- and gauche-23DCP have been diagonalized to allow comparison of coupling constants. Kraitchman's equations were used to determine r_s coordinates of isotopically substituted atoms and r_0 structures were also deduced for gauche conformers of 12DCE and 1C2FE. Structural details and chlorine nuclear quadrupole coupling constants of all three molecules will be compared, and effects of differing halogen substitution and carbon chain length on molecular properties will be evaluated.

  13. The ‘Eigenständig werden’ prevention trial: a cluster randomised controlled study on a school-based life skills programme to prevent substance use onset

    PubMed Central

    Hanewinkel, Reiner; Maruska, Karin; Isensee, Barbara

    2011-01-01

    Objective To implement and evaluate ‘Eigenständig werden 5+6’ (‘Becoming Independent 5+6’), a school-based curriculum for grades 5 and 6 developed on the basis of evidence-based criteria for effective drug prevention curricula in schools. Evaluation of the programme includes efficacy, feasibility and practicability in daily school routine. Methods and results The intervention ‘Eigenständig werden 5+6’ consists of 14 teaching units evenly distributed over grades 5 and 6 which are interactively delivered, and a parent component. Programme effects are studied in a four wave cluster randomised controlled trial with two arms, an intervention and a control group. Self-completed questionnaires from students and teachers are collected by trained research staff. 45 schools, 172 classes and 3444 students with a mean age of 10.37 years (SD=0.59) and 47.9% girls from four federal states in Germany were assessed at baseline. 1685 students in 81 classes were assigned to intervention classes, 1759 students in 91 classes to the control arm. No differences between conditions were found for age, gender, immigration background, socioeconomic status, substance use or life skills at baseline. Exceptions were higher self-efficacy (t(3438)=2.34, p=0.02, d=0.08) and empathy (t(3302)=2.4, p=0.02, d=0.09) in the control group, whereas class climate seemed better in the intervention group (t(3037)=2.01, p=0.05, d=0.07), but effect sizes state marginal differences. Conclusion Baseline data suggest that the initial conditions are favourable for testing programme efficacy since distribution of baseline levels of the outcomes did not differ in the intervention and control groups, except for negligible differences between self-efficacy and empathy, which were higher in the control group, and class climate, which was higher in the intervention group. Trial registration number Current Controlled Trials ISRCTN99442407. PMID:22080541

  14. A combined toxicokinetics and toxicodynamics approach to assess the effect of porewater composition on cadmium bioavailability to Folsomia candida.

    PubMed

    Ardestani, Masoud M; Oduber, Fedor; van Gestel, Cornelis A M

    2014-07-01

    The aim of the present study was to improve our understanding of cadmium bioavailability by linking toxicokinetics and toxicodynamics. The springtail Folsomia candida was exposed to different cadmium concentrations in solutions embedded in inert quartz sand. Survival and cadmium uptake in the animals were followed for 21 d. After 10 d, some animals were transferred to clean medium to assess cadmium elimination. Using a first-order one-compartment model, an overall uptake rate constant (k1) of 0.18 L kg(animal)(-1) d(-1) and an elimination rate constant (k(2-TK)) of 0.02 d(-1) were calculated. Survival decreased with time, resulting in an estimated final median lethal concentration (LC50) of 0.51 mM. A lethal body concentration (LBC) of 4.6 µmol Cd g(-1) dry body weight was estimated by multiplying the final LC50 by the bioconcentration factor (k1/k(2-TK)). The LC50(animal) values based on internal cadmium concentrations were between 3.56 µmol Cd g(-1) and 9.91 µmol Cd g(-1) dry body weight, with an overall value of 7.9 µmol Cd g(-1) dry body weight (95% confidence interval [CI]: 3.8-12.0 µmol Cd g(-1) dry body wt). Because the 95% CI of the LC50(animal) included the LBC, there was good agreement of cadmium toxicokinetics and toxicodynamics. PMID:24846504

  15. Submicrometer-wide amorphous and polycrystalline anatase TiO2 waveguides for microphotonic devices.

    PubMed

    Bradley, Jonathan D B; Evans, Christopher C; Choy, Jennifer T; Reshef, Orad; Deotare, Parag B; Parsy, François; Phillips, Katherine C; Lončar, Marko; Mazur, Eric

    2012-10-01

    We demonstrate amorphous and polycrystalline anatase TiO(2) thin films and submicrometer-wide waveguides with promising optical properties for microphotonic devices. We deposit both amorphous and polycrystalline anatase TiO(2) using reactive sputtering and define waveguides using electron-beam lithography and reactive ion etching. For the amorphous TiO(2), we obtain propagation losses of 0.12 ± 0.02 dB/mm at 633 nm and 0.04 ± 0.01 dB/mm at 1550 nm in thin films and 2.6 ± 0.5 dB/mm at 633 nm and 0.4 ± 0.2 dB/mm at 1550 nm in waveguides. Using single-mode amorphous TiO(2) waveguides, we characterize microphotonic features including microbends and optical couplers. We show transmission of 780-nm light through microbends having radii down to 2 μm and variable signal splitting in microphotonic couplers with coupling lengths of 10 μm. PMID:23188347

  16. Disentangling the Effect of Valence and Arousal on Judgments Concerning Moral Transgressions.

    PubMed

    de la Viña, Luis; Garcia-Burgos, David; Okan, Yasmina; Cándido, Antonio; González, Felisa

    2015-01-01

    An increasing body of research has investigated the effect of emotions on judgments concerning moral transgressions. Yet, few studies have controlled for arousal levels associated with the emotions. High arousal may affect moral processing by triggering attention to salient features of transgressions, independently of valence. Therefore previously documented differences in effects of negative and positive emotions may have been confounded by differences in arousal. We conducted two studies to shed light on this issue. In Study 1 we developed a questionnaire including vignettes selected on the basis of psychometrical properties (i.e., mean ratings of the actions and variability). This questionnaire was administered to participants in Study 2, after presenting them with selected pictures inducing different valence but equivalent levels of arousal. Negative pictures led to more severe moral judgments than neutral (p = .054, d = 0.60) and positive pictures (p = .002, d = 1.02), for vignettes that were not associated with extreme judgments. In contrast, positive pictures did not reliably affect judgments concerning such vignettes. These findings suggest that the observed effects of emotions cannot be accounted for by an increase in attention linked to the arousal which accompanies these emotions.

  17. Digital test signal generation: An accurate SNR calibration approach for the DSN

    NASA Technical Reports Server (NTRS)

    Gutierrez-Luaces, Benito O.

    1993-01-01

    In support of the on-going automation of the Deep Space Network (DSN) a new method of generating analog test signals with accurate signal-to-noise ratio (SNR) is described. High accuracy is obtained by simultaneous generation of digital noise and signal spectra at the desired bandwidth (base-band or bandpass). The digital synthesis provides a test signal embedded in noise with the statistical properties of a stationary random process. Accuracy is dependent on test integration time and limited only by the system quantization noise (0.02 dB). The monitor and control as well as signal-processing programs reside in a personal computer (PC). Commands are transmitted to properly configure the specially designed high-speed digital hardware. The prototype can generate either two data channels modulated or not on a subcarrier, or one QPSK channel, or a residual carrier with one biphase data channel. The analog spectrum generated is on the DC to 10 MHz frequency range. These spectra may be up-converted to any desired frequency without loss on the characteristics of the SNR provided. Test results are presented.

  18. Particulate organics degradation and sludge minimization in aerobic, complete SRT bioreactors.

    PubMed

    Amanatidou, Elisavet; Samiotis, Georgios; Trikoilidou, Eleni; Tsikritzis, Lazaros

    2016-05-01

    The study evaluates the assumption that in activated sludge processes and under specific operating conditions, the considered unbiodegradable particulate organic fractions of influent (XU) organic solids and biomass decay residues (cell debris, XE) are degraded. The evaluation was performed by comparing sludge observed yield (Yobs) evolution in two full scale, complete solids retention time (SRT), aerobic bioreactors, to the predictions of two activated sludge models. The results showed that in steady state operating conditions of complete solids retention AS processes very low solids accumulation occur. In these conditions, solids accumulation is slightly affected by kinetic coefficients and significantly affected by XU and XE degradation rates. High endogenous residues degradation rate values of 0.05 d(-1) and 0.02 d(-1) were estimated for the two bioreactors, resulting in low solids accumulation, calculated at 1.6 tons and 3.59 tons per year respectively, of which 1.37 and 0.87 tons were non volatile suspended solids. Depending on WWTP operating conditions the endogenous residues degradation rate is the limiting factor of solids accumulation and consequently for particulate organics degradation.

  19. Purification of a diatom and its identification to Cylindrotheca closterium

    NASA Astrophysics Data System (ADS)

    Wang, Song; Zhang, Lin; Yang, Guanpin; Zhu, Baohua; Pan, Kehou

    2015-04-01

    A diatom was purified with colony selection and continuous dilution methods. It was identified to Cylindrotheca closterium according to its morphological characteristics and rbcL and 18s rRNA gene sequences. The alga was not sensitive to ampicillin and neomycin, but sensitive to chloramphenicol which inhibited its growth at concentrations ranging from 50 to 150 μg mL-1. The purified alga was easy to culture and its specific growth rate was 0.207 ± 0.002 (d-1). It was resistant to pollution and could be harvested in an easy way. It was relatively high in lipid content (20.08% ± 0.67% of dry weight) and the combined amount of its 16:0 and 16:1 (n-7), the most suitable resource of biodiesel, was as high as 64% of the total fatty acids, while the amount of polyunsaturated fatty acids reached 19.96%-20% of the total fatty acids. Thus the purified C. closterium can be cultured as a biodiesel producer or a nutrition supplement producer.

  20. Acute Physical Exercise Affects Cognitive Functioning in Children With Cerebral Palsy.

    PubMed

    Maltais, Désirée B; Gane, Claire; Dufour, Sophie-Krystale; Wyss, Dominik; Bouyer, Laurent J; McFadyen, Bradford J; Zabjek, Karl; Andrysek, Jan; Voisen, Julien I

    2016-05-01

    Little is known about the effects of acute exercise on the cognitive functioning of children with cerebral palsy (CP). Selected cognitive functions were thus measured using a pediatric version of the Stroop test before and after maximal, locomotor based aerobic exercise in 16 independently ambulatory children (8 children with CP), 6-15 years old. Intense exercise had: 1) a significant, large, positive effect on reaction time (RT) for the CP group (preexercise: 892 ± 56.5 ms vs. postexercise: 798 ± 45.6 ms, p < .002, d = 1.87) with a trend for a similar but smaller response for the typically developing (TD) group (preexercise: 855 ± 56.5 ms vs. postexercise: 822 ± 45.6 ms, p < .08, d = 0.59), and 2) a significant, medium, negative effect on the interference effect for the CP group (preexercise: 4.5 ± 2.5%RT vs. postexercise: 13 ± 2.9%RT, p < .04, d = 0.77) with no significant effect for the TD group (preexercise: 7.2 ± 2.5%RT vs. postexercise: 6.9 ± 2.9%RT, p > .4, d = 0.03). Response accuracy was high in both groups pre- and postexercise (>96%). In conclusion, intense exercise impacts cognitive functioning in children with CP, both by increasing processing speed and decreasing executive function. PMID:26502458

  1. Abundance, seasonal patterns and diet of the non-native jellyfish Blackfordia virginica in a Portuguese estuary

    NASA Astrophysics Data System (ADS)

    Marques, F.; Chainho, P.; Costa, J. L.; Domingos, I.; Angélico, M. M.

    2015-12-01

    Blackfordia virginica, a non-indigenous hydrozoan introduced in many systems around the world, has been observed in the Mira estuary, southwest of Portugal, since 1984. Monthly sampling (January 2013-January 2014) at a fixed location with high abundance of the medusae confirmed the occurrence of a seasonal cycle associated with temperature and photoperiod. The beginning of the medusa cycle occurred in May immediately after the spring zooplankton bloom during April. Examination of the gut contents of B. virginica medusae revealed that copepods, the most abundant group in the zooplankton community, were highly predated. Barnacle nauplii, decapod crustacean larvae and anchovy eggs were also identified in the guts. The medusae showed positive selection for copepods, and negative selection for barnacle nauplii, decapod crustacean larvae and anchovy eggs. The mortality rate of copepods (used as a model prey group) induced by medusae predation was estimated and showed the potential impact of this species in the ecosystem, ranging between 2.34 d-1 and 0.02 d-1, with a minimum copepod half-life of 0.30 days.

  2. Evaluation of a seven-week web-based happiness training to improve psychological well-being, reduce stress, and enhance mindfulness and flourishing: a randomized controlled occupational health study.

    PubMed

    Feicht, T; Wittmann, M; Jose, G; Mock, A; von Hirschhausen, E; Esch, T

    2013-01-01

    Background. As distress in society increases, including work environments, individual capacities to compete with stress have to be strengthened. Objective. We examined the impact of a web-based happiness training on psychological and physiological parameters, by self-report and objective means, in an occupational health setting. Methods. Randomized controlled trial with 147 employees. Participants were divided into intervention (happiness training) and control groups (waiting list). The intervention consisted of a seven-week online training. Questionnaires were administered before, after, and four weeks after training. The following scales were included: VAS (happiness and satisfaction), WHO-5 Well-being Index, Stress Warning Signals, Freiburg Mindfulness Inventory, Recovery Experience Questionnaire, and Flourishing Scale. Subgroup samples for saliva cortisol and alpha-amylase determinations were taken, indicating stress, and Attention Network Testing for effects on attention regulation. Results. Happiness (P = 0.000; d = 0.93), satisfaction (P = 0.000; d = 1.17), and quality of life (P = 0.000; d = 1.06) improved; perceived stress was reduced (P = 0.003; d = 0.64); mindfulness (P = 0.006; d = 0.62), flourishing (P = 0.002; d = 0.63), and recovery experience (P = 0.030; d = 0.42) also increased significantly. No significant differences in the Attention Network Tests and saliva results occurred (intergroup), except for one saliva value. Conclusions. The web-based training can be a useful tool for stabilizing health/psychological well-being and work/life balance.

  3. Internet-based preventive intervention for reducing eating disorder risk: A randomized controlled trial comparing guided with unguided self-help.

    PubMed

    Kass, Andrea E; Trockel, Mickey; Safer, Debra L; Sinton, Meghan M; Cunning, Darby; Rizk, Marianne T; Genkin, Brooke H; Weisman, Hannah L; Bailey, Jakki O; Jacobi, Corinna; Wilfley, Denise E; Taylor, C Barr

    2014-12-01

    Student Bodies, an internet-based intervention, has successfully reduced weight/shape concerns and prevented eating disorders in a subset of college-age women at highest risk for an eating disorder. Student Bodies includes an online, guided discussion group; however, the clinical utility of this component is unclear. This study investigated whether the guided discussion group improves program efficacy in reducing weight/shape concerns in women at high risk for an eating disorder. Exploratory analyses examined whether baseline variables predicted who benefitted most. Women with high weight/shape concerns (N = 151) were randomized to Student Bodies with a guided discussion group (n = 74) or no discussion group (n = 77). Regression analyses showed weight/shape concerns were reduced significantly more among guided discussion group than no discussion group participants (p = 0.002; d = 0.52); guided discussion group participants had 67% lower odds of having high-risk weight/shape concerns post-intervention (p = 0.02). There were no differences in binge eating at post-intervention between the two groups, and no moderators emerged as significant. Results suggest the guided discussion group improves the efficacy of Student Bodies in reducing weight/shape concerns in college students at high risk for an eating disorder. PMID:25461783

  4. Biotransformation of chlorpyrifos in riparian wetlands in agricultural watersheds: implications for wetland management.

    PubMed

    Karpuzcu, M Ekrem; Sedlak, David L; Stringfellow, William T

    2013-01-15

    Biodegradation of the organophosphate insecticide chlorpyrifos (O,O-diethyl O-(3,5,6-trichloropyridin-2-yl) phosphorothioate) in sediments from wetlands and agricultural drains in San Joaquin Valley, CA was investigated. Sediments were collected monthly, spiked with chlorpyrifos, and rates of chlorpyrifos degradation were measured using a standardized aerobic biodegradation assay. Phosphoesterase enzyme activities were measured and phosphotriesterase activity was related to observed biodegradation kinetics. First-order biodegradation rates varied between 0.02 and 0.69 day(-1), after accounting for abiotic losses. The average rate of abiotic chlorpyrifos hydrolysis was 0.02 d(-1) at pH 7.2 and 30 °C. Sediments from the site exhibiting the highest chlorpyrifos degradation capacity were incubated under anaerobic conditions to assess the effect of redox conditions on degradation rates. Half-lives were 5 and 92 days under aerobic and anaerobic conditions, respectively. There was a consistent decrease in observed biodegradation rates at one site due to permanently flooded conditions prevailing during one sampling year. These results suggest that wetland management strategies such as allowing a wet-dry cycle could enhance degradation rates. There was significant correlation between phosphotriesterase (PTE) activity and the chlorpyrifos biotransformation rates, with this relationship varying among sites. PTE activities may be useful as an indicator of biodegradation potential with reference to the previously established site-specific correlations.

  5. Randomized controlled trial of the effect of a home visiting intervention on infant cognitive development in peri-urban South Africa

    PubMed Central

    Murray, Lynne; Cooper, Peter; Arteche, Adriane; Stein, Alan; Tomlinson, Mark

    2016-01-01

    Summary Aim To determine whether, in an impoverished South African community, an intervention that benefitted infant attachment also benefitted cognitive development. Method Pregnant women were randomized to intervention (220) and no treatment control groups (229). The intervention was home-based parenting support for attachment, delivered until six months postpartum. At 18 months, infants were assessed on attachment6, and cognitive development (Bayley MDI) (127 intervention, 136 control). Infant MDI was examined in relation to intervention, socio-economic risk, antenatal depression, and infant sex and attachment. Results Overall, there was little effect of the intervention on MDI (p=.094, d=0.20), but there was an interaction between intervention and risk (p=.03, ŋp2=.02): MDI scores of infants of lower risk intervention group mothers were, on average, 4·84 points higher than those of other infants (p=.002, d=.41). Antenatal depression was not significant once intervention and risk were controlled (p= .08); there was no association between infant MDI and either sex (p =.41) or attachment (p=.56). Conclusion Parenting interventions for infant cognitive development may benefit from inclusion of specific components to support infant cognition, beyond those that support attachment, and may be most effective for infants over six months. They may need augmentation with other input where adversity is extreme. PMID:26303135

  6. A theoretical study of the infrared vibrational intensities of CH3F

    NASA Astrophysics Data System (ADS)

    Sosa, Carlos; Schlegel, H. Bernhard

    1987-06-01

    The atomic polar tensors, vibrational frequencies, and infrared intensities were calculated for methyl fluoride using ab initio molecular orbital methods. Calculations were carried out using several split-valence basis sets (3-21G, D95, 6-31G, 6-311G) augmented with various numbers of diffuse and polarization functions. The CID/6-31G(d) optimized geometry was found to agree well with the experimental geometry and was used for all of the calculations. Atomic polar tensors were computed by analytical differentiation of the dipole moment at the Hartree-Fock level, and by numerical differentiation at the CISD level. The Hartree-Fock limit of the dipole moment is estimated to be 2.06±0.02 D at the CID/6-31G(d) optimized geometry. Compared with the observed, anharmonic vibrational frequencies, the calculated frequencies are an average of 8±4% too high at the HF/6-311++G(3d,3p) level, with larger errors for bending modes than for stretches. When correlation corrections are included the errors are significantly smaller and more uniform, 4.4±1.0%. Infrared intensities are much more sensitive to basis set effects than frequencies, requiring multiple sets of polarization functions, diffuse functions, and correlation corrections. A useful relation has been found between the calculated molecular dipole moment and the intensity of the CF stretching mode.

  7. Bent channel design in buried Er3+/Yb3+ codoped phosphate glass waveguide fabricated by field-assisted annealing

    NASA Astrophysics Data System (ADS)

    Zhao, Ruitu; Wang, Mu; Chen, Baojie; Liu, Ke; Pun, Edwin Yue-Bun; Lin, Hai

    2011-04-01

    Bent waveguide structures (S-, U-, and F-bend) based on buried Er3+/Yb3+ codoped phosphate glass waveguide channel fabricated by field-assisted annealing have been designed to achieve high-gain C-band integrated amplification. Using a simulated-bend method, the optimal radius for the curved structure is derived to be 0.90 cm with loss coefficient of 0.02 dB/cm, as the substrate size is schemed to be 4×3 cm2. In the wavelength range of 1520 to 1575 nm, obvious gain enhancement for the bent structure waveguides is anticipated, and for the F-bend waveguide, the internal gain at 1534-nm wavelength is derived to be 41.61 dB, which is much higher than the value of 26.22 and 13.81 dB in the U- and S-bend waveguides, respectively, and over three times higher than that of the straight one. The simulation results indicate that the bent structure design is beneficial in obtaining high signal gain in buried Er3+/Yb3+ codoped phosphate glass waveguides, which lays the foundation for further design and fabrication of integrated devices.

  8. Low-loss sharp bends in low contrast polymer hybrid metallic waveguides

    NASA Astrophysics Data System (ADS)

    Sefunc, M. A.; van de Meent, W.; Coenen, A. R.; Pace, A.; Dijkstra, M.; García-Blanco, S. M.

    2015-02-01

    Surface plasmons polaritons have drawn significant attention in recent years not only thanks to their capability of confining the field in the dielectric/metal interface, but also thanks to their potential to produce highly efficient thermooptical or electro-optical devices such as modulators and switches due to the presence of the metal layer amidst the electromagnetic field. However, the high confinement comes at the cost of high propagation losses due to the metal's highly absorptive nature at visible and near-IR wavelengths. In order for plasmonic devices to find a widespread use in integrated optics, an advantage over dielectric waveguides needs to be found that justifies their utilization. In this work, we present an application in which metallic waveguides perform better than their dielectric counterparts. By adding a thin metallic layer underneath the waveguide core, the total bend losses (dB/90° are reduced with respect to the bend losses of the equivalent dielectric structure without the metallic layer for a range of radii from 35 µm down to 1 µm. The results show a dramatic reduction of total bend losses in TE-polarization with values as low as 0.02 dB/90° bend for radii between 6 and 13 µm. The mechanism for the reduction of bend losses is the shielding action of the metal layer, which prevents the field to leak into the substrate. In this paper, both detailed theoretical calculations as well as experimental results for SU-8 channel waveguides will be presented.

  9. Low-Power Testing of Losses in Millimeter-Wave Transmission Lines for High-Power Applications.

    PubMed

    Han, S T; Comfoltey, E N; Shapiro, M A; Sirigiri, J R; Tax, D S; Temkin, R J; Woskov, P P; Rasmussen, D A

    2008-11-01

    We report the measurement of small losses in transmission line (TL) components intended for high-power millimeter-wave applications. Measurements were made using two different low-power techniques: a coherent technique using a vector network analyzer (VNA) and an incoherent technique using a radiometer. The measured loss in a 140 GHz 12.7 mm diameter TL system, consisting of 1.7 m of circular corrugated waveguide and three miter bends, is dominated by the miter bend loss. The measured loss was 0.3±0.1 dB per miter bend using a VNA; and 0.22±0.1 dB per miter bend using a radiometer. Good agreement between the two measurement techniques implies that both are useful for measuring small losses. To verify the methodology, the VNA technique was employed to measure the extremely small transmission loss in a 170 GHz ITER prototype TL system consisting of three lengths of 1 m, 63.5 mm diameter, circular corrugated waveguide and two miter bends. The measured loss of 0.05±0.02 dB per miter bend may be compared with the theoretical loss of 0.027 dB per miter bend. These results suggest that low-power testing of TL losses, utilizing a small, simple TL system and a VNA, is a reliable method for evaluating performance of low-loss millimeter-wave TL components intended for use in high-power applications.

  10. Long-term changes in ground water chemistry at a phytoremediation demonstration site

    USGS Publications Warehouse

    Eberts, S.M.; Jones, S.A.; Braun, C.L.; Harvey, G.J.

    2005-01-01

    A field-scale demonstration project was conducted to evaluate the capability of eastern cottonwood trees (Populus deltoides) to attenuate trichloroethene (TCE) contamination of ground water. By the middle of the sixth growing season, trees planted where depth to water was < 3 m delivered enough dissolved organic carbon to the underlying aquifer to lower dissolved oxygen concentrations, to create iron-reducing conditions along the plume centerline and sulfate-reducing or methanogenic conditions in localized areas, and to initiate in situ reductive dechlorination of TCE. Apparent biodegradation rate constants for TCE along the centerline of the plume beneath the phytoremediation system increased from 0.0002/d to 0.02/d during the first six growing seasons. The corresponding increase in natural attenuation capacity of the aquifer along the plume centerline, from 0.0004/m to 0.024/m, is associated with a potential decrease in plume-stabilization distance from 9680 to 160 m. Demonstration results provide insight into the amount of vegetation and time that may be needed to achieve cleanup objectives at the field scale.

  11. Low-Power Testing of Losses in Millimeter-Wave Transmission Lines for High-Power Applications

    SciTech Connect

    Han, S. T.; Comfoltey, E. N.; Shapiro, Michael; Sirigiri, Jagadishwar R.; Tax, David; Temkin, Richard J; Woskov, P. P.; Chang, Won; Rasmussen, David A

    2008-08-01

    We report the measurement of small losses in transmission line (TL) components intended for high-power millimeter-wave applications. Measurements were made using two different low-power techniques: a coherent technique using a vector network analyzer (VNA) and an incoherent technique using a radiometer. The measured loss in a 140 GHz 12.7 mm diameter TL system, consisting of 1.7 m of circular corrugated waveguide and three miter bends, is dominated by the miter bend loss. The measured loss was 0.3 {+-} 0.1 dB per miter bend using a VNA; and 0.22 {+-} 0.1 dB per miter bend using a radiometer. Good agreement between the two measurement techniques implies that both are useful for measuring small losses. To verify the methodology, the VNA technique was employed to measure the extremely small transmission loss in a 170 GHz ITER prototype TL system consisting of three lengths of 1 m, 63.5 mm diameter, circular corrugated waveguide and two miter bends. The measured loss of 0.05 {+-} 0.02 dB per miter bend may be compared with the theoretical loss of 0.027 dB per miter bend. These results suggest that low-power testing of TL losses, utilizing a small, simple TL system and a VNA, is a reliable method for evaluating performance of low-loss millimeter-wave TL components intended for use in high-power applications.

  12. High altitude impairs in vivo immunity in humans.

    PubMed

    Oliver, Samuel J; Macdonald, Jamie H; Harper Smith, Adam D; Lawley, Justin S; Gallagher, Carla A; Di Felice, Umberto; Walsh, Neil P

    2013-06-01

    The aim was to assess the effect of high altitude on the development of new immune memory (induction) using a contact sensitization model of in vivo immunity. We hypothesized that high-altitude exposure would impair induction of the in vivo immune response to a novel antigen, diphenylcyclopropenone (DPCP). DPCP was applied (sensitization) to the lower back of 27 rested controls at sea level and to ten rested mountaineers 28 hours after passive ascent to 3777 m. After sensitization, mountaineers avoided strenuous exercise for a further 24 hours, after which they completed alpine activities for 11-18 days. Exactly 4 weeks after sensitization, the strength of immune memory induction was quantified in rested mountaineers and controls at sea level, by measuring the response to a low, dose-series DPCP challenge, read at 48 hours as skin measures of edema (skinfold thickness) and redness (erythema). Compared with control responses, skinfold thickness and erythema were reduced in the mountaineers (skinfold thickness,-52%, p=0.01, d=0.86; erythema, -36%, p=0.02, d=0.77). These changes in skinfold thickness and erythema were related to arterial oxygen saturation (r=0.7, p=0.04), but not cortisol (r<0.1, p>0.79), at sensitization. In conclusion, this is the first study to show, using a contact sensitization model of in vivo immunity, that high altitude exposure impairs the development of new immunity in humans.

  13. Internet-based preventive intervention for reducing eating disorder risk: A randomized controlled trial comparing guided with unguided self-help

    PubMed Central

    Kass, Andrea E.; Trockel, Mickey; Safer, Debra L.; Sinton, Meghan M.; Cunning, Darby; Rizk, Marianne T.; Genkin, Brooke H.; Weisman, Hannah L.; Bailey, Jakki O.; Jacobi, Corinna; Wilfley, Denise E.; Taylor, C. Barr

    2014-01-01

    Student Bodies, an internet-based intervention, has successfully reduced weight/shape concerns and prevented eating disorders in a subset of college-age women at highest risk for an eating disorder. Student Bodies includes an online, guided discussion group; however, the clinical utility of this component is unclear. This study investigated whether the guided discussion group improves program efficacy in reducing weight/shape concerns in women at high risk for an eating disorder. Exploratory analyses examined whether baseline variables predicted who benefitted most. Women with high weight/shape concerns (N=151) were randomized to Student Bodies with a guided discussion group (n=74) or no discussion group (n=77). Regression analyses showed weight/shape concerns were reduced significantly more among guided discussion group than no discussion group participants (p = 0.002; d = 0.52); guided discussion group participants had 67% lower odds of having high-risk weight/shape concerns post-intervention (p = 0.02). There were no differences in binge eating at post-intervention between the two groups, and no moderators emerged as significant. Results suggest the guided discussion group improves the efficacy of Student Bodies in reducing weight/shape concerns in college students at high risk for an eating disorder. PMID:25461783

  14. Loss reduction of leaky surface acoustic wave by loading with high-velocity thin film

    NASA Astrophysics Data System (ADS)

    Kakio, Shoji; Hosaka, Keiko

    2016-07-01

    The propagation properties of a leaky surface acoustic wave (LSAW) on rotated Y-cut X-propagating lithium niobate (YX-LN) substrates loaded with an aluminum nitride (AlN) thin film with a higher phase velocity than that of the substrate were investigated theoretically and experimentally. From the theoretical calculation, it was found that the minimum attenuation can be obtained at a certain thickness of the AlN thin film for a cut angle ranging from 0 to 60° because the cut angle giving the minimum attenuation shifts toward a smaller cut angle as the film thickness is increased. The propagation properties of an LSAW on several rotated YX-LN substrates were measured by using an interdigital transducer (IDT) pair with a wavelength λ of 8 µm, and the predicted shifts of the minimum attenuation toward a smaller cut angle were demonstrated experimentally. For 0° and 10°YX-LN samples, the measured insertion loss and propagation loss were markedly reduced by loading with the AlN thin film. A larger electromechanical coupling factor (16.9%) than that at the cut angle giving zero attenuation without a film and a propagation loss less of 0.02 dB/λ were obtained simultaneously at a film thickness of 0.125 λ for the 10°YX-LN sample.

  15. Highly Compact Circulators in Square-Lattice Photonic Crystal Waveguides

    PubMed Central

    Jin, Xin; Ouyang, Zhengbiao; Wang, Qiong; Lin, Mi; Wen, Guohua; Wang, Jingjing

    2014-01-01

    We propose, demonstrate and investigate highly compact circulators with ultra-low insertion loss in square-lattice- square-rod-photonic-crystal waveguides. Only a single magneto- optical square rod is required to be inserted into the cross center of waveguides, making the structure very compact and ultra efficient. The square rods around the center defect rod are replaced by several right-angled-triangle rods, reducing the insertion loss further and promoting the isolations as well. By choosing a linear-dispersion region and considering the mode patterns in the square magneto-optical rod, the operating mechanism of the circulator is analyzed. By applying the finite-element method together with the Nelder-Mead optimization method, an extremely low insertion loss of 0.02 dB for the transmitted wave and ultra high isolation of 46 dB∼48 dB for the isolated port are obtained. The idea presented can be applied to build circulators in different wavebands, e.g., microwave or Tera-Hertz. PMID:25415417

  16. Characterization of low thermal conductivity PAN-based carbon fibers

    NASA Technical Reports Server (NTRS)

    Katzman, Howard A.; Adams, P. M.; Le, T. D.; Hemminger, Carl S.

    1992-01-01

    The microstructure and surface chemistry of eight low thermal conductivity (LTC) PAN-based carbon fibers were determined and compared with PAN-based fibers heat treated to higher temperatures. Based on wide-angle x ray diffraction, the LTC PAN fibers all appear to have a similar turbostratic structure with large 002 d-spacings, small crystallite sizes, and moderate preferred orientation. Limited small-angle x ray scattering (SAXS) results indicate that, with the exception of LTC fibers made by BASF, the LTC fibers do not have well developed pores. Transmission electron microscopy shows that the texture of the two LTC PAN-based fibers studied (Amoco T350/23X and /25X) consists of multiple sets of parallel, wavy, bent layers that interweave with each other forming a complex three dimensional network oriented randomly around the fiber axis. X ray photoelectron spectroscopy (XPS) analysis finds correlations between heat treated temperatures and the surface composition chemistry of the carbon fiber samples.

  17. Development of High-resolution Real-Time Strong Motion Observation Network in CEORKA

    NASA Astrophysics Data System (ADS)

    Akazawa, T.; Araki, M.; Sawada, S.; Hayashi, Y.; Horike, M.

    2011-12-01

    The Committee of Earthquake Observation and Research in the Kansai Area (CEORKA), distributing 20 stations throughout the Kansai district in Japan, has obtained many velocity records, not only during major earthquakes (e.g. 1995 Kobe Earthquake and 2011 Tohoku Earthquake) but also during moderate ones (M>2) occurred in and near the district. The committee continues to use the old data loggers, which were installed in 1994 and 1997. It takes more than one hour after the shaking to collect the time history records, because dial-up telecommunication lines are used. In addition, the data logger starts saving the observed data when the ground shaking exceeds a preset level. This "trigger" system do not often store the valuable data properly. We develop a new low-cost data logger (KS-002D), which can send the observed data in real-time through Internet and save it in SD card continuously, for the network of CEORKA. The logger has eight input channels to obtain both high and low gain signals output from the existing strong motion seismograph (VSE-11 & 12). The logger also gets the high accuracy clock signals from GPS system. The observed data show that the new date logger can obtain broadband and high-resolution data from strong motion to microtremor. The developed data loggers are installed to the all stations of CEORKA, in addition to old loggers which are working as back-up systems.

  18. Transfer of Cs-137 from grass and wilted grass silage to milk of dairy cows.

    PubMed

    Vreman, K; van der Struijs, T D; van den Hoek, J; Berende, P L; Goedhart, P W

    1989-09-01

    Deposition of radiocaesium from the Chernobyl reactor accident on the Netherlands made it possible to collect contaminated fresh grass and first cut wilted grass silage. These contaminated roughages were used in transfer experiments with lactating dairy cows to determine transfer coefficients and half-lives for Cs-137 in milk. The experimental design was based on three consecutive periods: a preliminary period to determine the background concentration of the isotope in milk, a contamination period to determine the magnitude of accumulation and finally a depletion period to measure the rate at which the activity concentration of Cs-137 in milk declined after continuous feeding. The average transfer coefficient (Fmilk) for cows fed on contaminated dried grass under steady-state conditions was 0.002 d/kg and for cows fed on slightly contaminated second cut fresh grass 0.006 d/kg. The highest transfer coefficients were obtained for cows fed on contaminated grass silage for 119 days, which also included the dry period of about two months. For the first five days after calving the Fmilk values varied from 0.0066 to 0.0091 d/kg. There were no significant differences in transfer coefficients between cows in early lactation (third month of lactation), cows in late lactation (the last month of the lactation period) and cows fed on both contaminated grass silage and uncontaminated maize silage simultaneously. Half-life values for the rate of decline of the isotope in milk during the depletion period were estimated on the basis of a mathematical model with two exponential components. These components were characterized by half-lives of 0.5 to 3.5 days and 10 to 46 days. PMID:2814441

  19. Thinner Cortex in Collegiate Football Players With, but not Without, a Self-Reported History of Concussion.

    PubMed

    Meier, Timothy B; Bellgowan, Patrick S F; Bergamino, Maurizio; Ling, Josef M; Mayer, Andrew R

    2016-02-15

    Emerging evidence suggests that a history of sports-related concussions can lead to long-term neuroanatomical changes. The extent to which similar changes are present in young athletes is undetermined at this time. Here, we tested the hypothesis that collegiate football athletes with (n = 25) and without (n = 24) a self-reported history of concussion would have cortical thickness differences and altered white matter integrity relative to healthy controls (n = 27) in fronto-temporal regions that appear particularly susceptible to traumatic brain injury. Freesurfer software was used to estimate cortical thickness, fractional anisotropy was calculated in a priori white matter tracts, and behavior was assessed using a concussion behavioral battery. Groups did not differ in self-reported symptoms (p > 0.10) or cognitive performance (p > 0.10). Healthy controls reported significantly higher happiness levels than both football groups (all p < 0.01). Contrary to our hypothesis, no differences in fractional anisotropy were observed between our groups (p > 0.10). However, football athletes with a history of concussion had significantly thinner cortex in the left anterior cingulate cortex, orbital frontal cortex, and medial superior frontal cortex relative to healthy controls (p = 0.02, d = -0.69). Further, football athletes with a history of concussion had significantly thinner cortex in the right central sulcus and precentral gyrus relative to football athletes without a history of concussion (p = 0.03, d = -0.71). No differences were observed between football athletes without a history of concussion and healthy controls. These results suggest that previous concussions, but not necessarily football exposure, may be associated with cortical thickness differences in collegiate football athletes.

  20. Evaluating the trophic transfer of cadmium, polonium, and methylmercury in an estuarine food chain.

    PubMed

    Mathews, Teresa; Fisher, Nicholas S

    2008-05-01

    We examined the transfer of Cd, methylmercury (MeHg), and Po in an estuarine food chain (from phytoplankton to zooplankton [Daphnia pulex] to killifish [Fundulus heteroclitus] and, finally, to juvenile striped bass [Morone saxatilis]) to better understand both the extent to which these elements may biomagnify and the underlying mechanisms governing this biomagnification. Among the phytoplankton examined (Cyclotella meneghiniana and Chlamdomonas reinhardtii), metal uptake was rapid, and volume concentration factors for all metals reached values between 10(4) and 10(5). The resulting assimilation efficiencies (AEs) of ingested metals in all animals were highest for MeHg, with values greater than 76%. The AEs of Cd were 21 to 33% in D. pulex, 1 to 16% in F. heteroclitus, and 38 to 56% in M. saxatilis. Polonium AEs were 69 to 87% in D. pulex, 25 to 41% in F. heteroclitus, and 9 to 21% in M. saxatilis. Loss rate constants (ke) of metals in D. pulex ranged from 0.04/d for MeHg to 0.39/d for Po; metal ke values for F. heteroclitus ranged from 0.01 to 0.02/d. Using a kinetic model, we showed that the trophic transfer factor, defined as the ratio of metal concentration in predatory animals to metal concentration in prey organisms, was greater than unity for all three metals in D. pulex feeding on phytoplankton, suggesting that these metals may be biomagnified at this trophic step. In killifish feeding on D. pulex, the trophic transfer factor was consistently greater than one for MeHg, consistently less than one for Cd, and from 0.1 to 1.4 for Po, suggesting that both MeHg and Po have the potential to biomagnify at this trophic step.

  1. Biogeochemical factors influencing net mercury methylation in contaminated freshwater sediments from the St. Lawrence River in Cornwall, Ontario, Canada.

    PubMed

    Avramescu, Mary-Luyza; Yumvihoze, Emmanuel; Hintelmann, Holger; Ridal, Jeff; Fortin, Danielle; Lean, David R S

    2011-02-01

    The activity of various anaerobic microbes, including sulfate reducers (SRB), iron reducers (FeRP) and methanogens (MPA) has been linked to mercury methylation in aquatic systems, although the relative importance of each microbial group in the overall process is poorly understood in natural sediments. The present study focused on the biogeochemical factors (i.e. the relative importance of various groups of anaerobic microbes (FeRP, SRB, and MPA) that affect net monomethylmercury (MMHg) formation in contaminated sediments of the St. Lawrence River (SRL) near Cornwall (Zone 1), Ontario, Canada. Methylation and demethylation potentials were measured separately by using isotope-enriched mercury species ((200)Hg(2+) and MM(199)Hg(+)) in sediment microcosms treated with specific microbial inhibitors. Sediments were sampled and incubated in the dark at room temperature in an anaerobic chamber for 96h. The potential methylation rate constants (K(m)) and demethylation rates (K(d)) were found to differ significantly between microcosms. The MPA-inhibited microcosm had the highest potential methylation rate constant (0.016d(-1)), whereas the two SRB-inhibited microcosms had comparable potential methylation rate constants (0.003d(-1) and 0.002d(-1), respectively). The inhibition of methanogens stimulated net methylation by inhibiting demethylationand by stimulating methylation along with SRB activity. The inhibition of both methanogens and SRB was found to enhance the iron reduction rates but did not completely stop MMHg production. The strong positive correlation between K(m) and Sulfate Reduction Rates (SRR) and between K(d) and Methane Production Rates (MPR) supports the involvement of SRB in Hg methylation and MPA in MMHg demethylation in the sediments. In contrast, the strong negative correlation between K(d) and Iron Reduction Rates (FeRR) shows that the increase in FeRR corresponds to a decrease in demethylation, indicating that iron reduction may influence net

  2. Evaluation of a seven-week web-based happiness training to improve psychological well-being, reduce stress, and enhance mindfulness and flourishing: a randomized controlled occupational health study.

    PubMed

    Feicht, T; Wittmann, M; Jose, G; Mock, A; von Hirschhausen, E; Esch, T

    2013-01-01

    Background. As distress in society increases, including work environments, individual capacities to compete with stress have to be strengthened. Objective. We examined the impact of a web-based happiness training on psychological and physiological parameters, by self-report and objective means, in an occupational health setting. Methods. Randomized controlled trial with 147 employees. Participants were divided into intervention (happiness training) and control groups (waiting list). The intervention consisted of a seven-week online training. Questionnaires were administered before, after, and four weeks after training. The following scales were included: VAS (happiness and satisfaction), WHO-5 Well-being Index, Stress Warning Signals, Freiburg Mindfulness Inventory, Recovery Experience Questionnaire, and Flourishing Scale. Subgroup samples for saliva cortisol and alpha-amylase determinations were taken, indicating stress, and Attention Network Testing for effects on attention regulation. Results. Happiness (P = 0.000; d = 0.93), satisfaction (P = 0.000; d = 1.17), and quality of life (P = 0.000; d = 1.06) improved; perceived stress was reduced (P = 0.003; d = 0.64); mindfulness (P = 0.006; d = 0.62), flourishing (P = 0.002; d = 0.63), and recovery experience (P = 0.030; d = 0.42) also increased significantly. No significant differences in the Attention Network Tests and saliva results occurred (intergroup), except for one saliva value. Conclusions. The web-based training can be a useful tool for stabilizing health/psychological well-being and work/life balance. PMID:24489588

  3. Social communication deficits: Specific associations with Social Anxiety Disorder

    PubMed Central

    Halls, Georgia; Cooper, Peter J.; Creswell, Cathy

    2015-01-01

    Background Social communication deficits are prevalent amongst children with anxiety disorders; however whether they are over-represented specifically among children with Social Anxiety Disorder has not been examined. This study set out to examine social communication deficits among children with Social Anxiety Disorder in comparison to children with other forms of anxiety disorder. Methods Parents of 404 children with a diagnosed anxiety disorder completed the Social Communication Questionnaire (SCQ; Rutter, M., Bailey, A., Lord, C., 2003. The Social Communication Questionnaire – Manual. Western Psychological Services, Los Angeles, CA). Children with a diagnosis of Social Anxiety Disorder (n=262) and anxious children without Social Anxiety Disorder (n=142) were compared on SCQ total and subscale scores and the frequency of participants scoring above clinical cut-offs. Results Children with Social Anxiety Disorder scored significantly higher than anxious children without Social Anxiety Disorder on the SCQ total (t(352)=4.85, p<.001, d=.55, r=.27), Reciprocal Social Interaction (t(351)=4.73, p<.001, d=.55, r=.27), communication (t(344)=3.62, p<.001, d=.43, r=.21) and repetitive, restrictive and stereotyped behaviors subscales (t(353)=3.15, p=.002, d=.37, r=.18). Furthermore, children with Social Anxiety Disorder were three times more likely to score above clinical cut-offs. Limitations The participants were a relatively affluent group of predominantly non-minority status. The social communication difficulties measure relied on parental report which could be influenced by extraneous factors. Conclusions Treatments for Social Anxiety Disorder may benefit from a specific focus on developing social communication skills. Future research using objective assessments of underlying social communication skills is required. PMID:25451393

  4. Does a non-circular chainring improve performance in the bicycle motocross cycling start sprint?

    PubMed

    Mateo-March, Manuel; Fernández-Peña, Eneko; Blasco-Lafarga, Cristina; Morente-Sánchez, Jaime; Zabala, Mikel

    2014-01-01

    Maximising power output during the initial acceleration phase of a bicycle motocross (BMX) race increases the chance to lead the group for the rest of the race. The purpose of this study was to investigate the effect of non-circular chainrings (Q-ring) on performance during the initial acceleration phase of a BMX race. Sixteen male cyclists (Spanish National BMX team) performed two counterbalanced and randomized initial sprints (3.95s), using Q- ring vs. circular chainring, on a BMX track. The sample was divided into two different groups according to their performance (Elite; n = 8 vs. Cadet; n = 8). Elite group covered a greater distance using Q-ring (+0.26 m, p = 0.02; D = 0.23), whilst the improvement for the Cadet (+0.04 m) was not significant (p = 0.87; D = -0.02). Also, there was no significant difference in power output for the Elite group, while the Cadet group revealed larger peak power with the circular chainring. Neither lactate level, nor heart rate showed significant differences due to the different chainring used. The non-circular chainring improved the initial acceleration capacity only in the Elite riders. Key PointsThis work provides novel results demonstrating very significant improvements in the sprint performance of BMX cycling discipline using a non-circular chainring system.This study seeks a practical application from scientific analysisAll data are obtained in a real context of high competition using a sample comprised by the National Spanish Team.Some variables influencing performance as subjects' physical fitness are discussed.Technical equipment approved by International Cycling Union is studied to check its potentially beneficial influence on performance. PMID:24570612

  5. Effects of neonatal enteral glutamine supplementation on cognitive, motor and behavioural outcomes in very preterm and/or very low birth weight children at school age.

    PubMed

    de Kieviet, Jorrit F; Oosterlaan, Jaap; van Zwol, Annelies; Boehm, Guenther; Lafeber, Harrie N; van Elburg, Ruurd M

    2012-12-28

    In very preterm ( < 32 weeks of gestation) and/or very low birth weight (VLBW, < 1500 g birth weight) children, serious neonatal infections are among the main causes of poor developmental outcomes later in childhood. The amino acid glutamine has been shown to reduce the incidence of serious neonatal infections in very preterm and/or VLBW children, while developmental effects beyond 24 months are unknown. We determined the cognitive, motor and behavioural outcomes at school age of a cohort of sixty-four very preterm and/or VLBW children (aged 7·5 (sd 0·4) years) who participated in a randomised placebo-controlled trial using enteral glutamine between day 3 and day 30 of life. Cognitive and motor outcomes were studied using the Wechsler Intelligence Scale for Children-III, the Movement Assessment Battery for Children (MABC), the Attention Network Test and a visual working memory task. Behavioural outcomes were evaluated using parent- and teacher-rated questionnaires. Intelligence quotient, processing speed, attentional functioning, working memory and parent- and teacher-rated behavioural outcomes were not different between children treated with glutamine or placebo; only visuomotor abilities as measured by the Ball Skills scale of the MABC (P = 0·002; d = 0·67) were poorer in the glutamine group. This effect persisted after taking into account the beneficial effects of lower serious neonatal infections rates in children treated with glutamine (P = 0·005). In conclusion, glutamine supplementation between day 3 and day 30 of life had neither beneficial nor detrimental effects on long-term cognitive, motor and behavioural outcomes of very preterm and/or VLBW children at school age, although visuomotor abilities were poorer in children that received glutamine.

  6. Evaluation of a Seven-Week Web-Based Happiness Training to Improve Psychological Well-Being, Reduce Stress, and Enhance Mindfulness and Flourishing: A Randomized Controlled Occupational Health Study

    PubMed Central

    Feicht, T.; Wittmann, M.; Jose, G.; Mock, A.; von Hirschhausen, E.; Esch, T.

    2013-01-01

    Background. As distress in society increases, including work environments, individual capacities to compete with stress have to be strengthened. Objective. We examined the impact of a web-based happiness training on psychological and physiological parameters, by self-report and objective means, in an occupational health setting. Methods. Randomized controlled trial with 147 employees. Participants were divided into intervention (happiness training) and control groups (waiting list). The intervention consisted of a seven-week online training. Questionnaires were administered before, after, and four weeks after training. The following scales were included: VAS (happiness and satisfaction), WHO-5 Well-being Index, Stress Warning Signals, Freiburg Mindfulness Inventory, Recovery Experience Questionnaire, and Flourishing Scale. Subgroup samples for saliva cortisol and alpha-amylase determinations were taken, indicating stress, and Attention Network Testing for effects on attention regulation. Results. Happiness (P = 0.000; d = 0.93), satisfaction (P = 0.000; d = 1.17), and quality of life (P = 0.000; d = 1.06) improved; perceived stress was reduced (P = 0.003; d = 0.64); mindfulness (P = 0.006; d = 0.62), flourishing (P = 0.002; d = 0.63), and recovery experience (P = 0.030; d = 0.42) also increased significantly. No significant differences in the Attention Network Tests and saliva results occurred (intergroup), except for one saliva value. Conclusions. The web-based training can be a useful tool for stabilizing health/psychological well-being and work/life balance. PMID:24489588

  7. Carbon isotope fractionation in reactions of 1,2-dibromoethane with FeS and hydrogen sulfide.

    PubMed

    Kuder, Tomasz; Wilson, John T; Philp, Paul; He, Y Thomas

    2012-07-17

    EDB (1,2-dibromoethane) is frequently detected at sites impacted by leaded gasoline. In reducing environments, EDB is highly susceptible to abiotic degradation. A study was conducted to evaluate the potential of compound-specific isotope analysis (CSIA) in assessing abiotic degradation of EDB in sulfate-reducing environments. Water containing EDB was incubated in sealed vials with various combinations of Na(2)S (<0.7 mM) and mackinawite (FeS) (180 mM). Degradation rates in vials containing FeS exceeded those in Na(2)S-only controls. In the presence of FeS, first-order constants ranged from 0.034 ± 0.002 d(-1) at pH 6 to 0.081 ± 0.005 d(-1) at pH 8.5. In the presence of FeS, products from reductive debromination (ethylene) and from S(N)2 substitution with S(II) nucleophiles were detected (1,2-dithioethane, DTA). Relatively high yields of DTA suggested that the S(N)2 reactions were not mediated by HS(-) only but likely also included reactions mediated by FeS surface. Significant carbon isotope effects were observed for nucleophilic substitution by HS(-) (ε = -31.6 ± 3.7‰) and for a combination of reductive and substitution pathways in the presence of FeS (-30.9 ± 0.7‰), indicating good site assessment potential of CSIA. The isotope effects (KIEs) observed in the presence of FeS corroborated the predominance of S(N)2 substitution by nucleophiles combined with two-electron transfer reductive debromination.

  8. Markers of Endothelial Dysfunction, Coagulation and Tissue Fibrosis Independently Predict Venous Thromboembolism in HIV

    PubMed Central

    MUSSELWHITE, Laura W.; SHEIKH, Virginia; NORTON, Thomas D.; RUPERT, Adam; PORTER, Brian O.; PENZAK, Scott R.; SKINNER, Jeff; MICAN, JoAnn M.; HADIGAN, Colleen; SERETI, Irini

    2015-01-01

    Objective HIV infection is associated with coagulation abnormalities and significantly increased risk of venous thrombosis. It has been shown that higher plasma levels of coagulation and inflammatory biomarkers predicted mortality in HIV. We investigated the relationship between venous thrombosis and HIV-related characteristics, traditional risk factors of hypercoagulability and pre-event levels of biomarkers. Design A retrospective case-control study of 23 HIV-infected individuals who experienced an incident venous thromboembolic (VTE) event while enrolled in National Institutes of Health studies from 1995–2010 and 69 age and sex-matched HIV-infected individuals without known VTE. Methods Biomarkers of inflammation, endothelial dysfunction, coagulation, tissue fibrosis, and cytomegalovirus (CMV) reactivation were assessed by ELISA-based assays and PCR using plasma obtained prior to the event. Results VTE events were related to nadir CD4 count, lifetime history of multiple opportunistic infections, CMV disease, CMV viremia, immunological AIDS, active infection and provocation (i.e. recent hospitalization, surgery or trauma). VTE events were independently associated with increased plasma levels of P-selectin, P=0.002; D-dimer, P=0.01; and hyaluronic acid, P=0.009 in a multivariate analysis. No significant differences in antiretroviral or interleukin 2 exposures, plasma HIV viremia, or other traditional risk factors were observed. Conclusion Severe immunodeficiency, active infection and provocation are associated with venous thromboembolic disease in HIV. Biomarkers of endothelial dysfunction, coagulation and tissue fibrosis may help identify HIV-infected patients at elevated risk of VTE. PMID:21412059

  9. Hard X-Ray Emission from Sh 2–104: A NuSTAR Search for Gamma-Ray Counterparts

    NASA Astrophysics Data System (ADS)

    Gotthelf, E. V.; Mori, K.; Aliu, E.; Paredes, J. M.; Tomsick, J. A.; Boggs, S. E.; Christensen, F. E.; Craig, W. W.; Hailey, C. J.; Harrison, F. A.; Hong, J. S.; Rahoui, F.; Stern, D.; Zhang, W. W.

    2016-07-01

    We present NuSTAR hard X-ray observations of Sh 2–104, a compact H ii region containing several young massive stellar clusters (YMSCs). We have detected distinct hard X-ray sources coincident with localized VERITAS TeV emission recently resolved from the giant gamma-ray complex MGRO J2019+37 in the Cygnus region. Fainter, diffuse X-rays coincident with the eastern YMSC in Sh2-104 likely result from the colliding winds of a component star. Just outside the radio shell of Sh 2–104 lies 3XMM J201744.7+365045 and a nearby nebula, NuSTAR J201744.3+364812, whose properties are most consistent with extragalactic objects. The combined XMM-Newton and NuSTAR spectrum of 3XMM J201744.7+365045 is well-fit to an absorbed power-law model with {N}{{H}}=(3.1+/- 1.0)× {10}22 cm‑2 and a photon index {{Γ }}=2.1+/- 0.1. Based on possible long-term flux variation and the lack of detected pulsations (≤43% modulation), this object is likely a background active galactic nucleus rather than a Galactic pulsar. The spectrum of the NuSTAR nebula shows evidence of an emission line at E = 5.6 keV, suggesting an optically obscured galaxy cluster at z = 0.19 ± 0.02 (d = 800 Mpc) and L X = 1.2 × 1044 erg s‑1. Follow-up Chandra observations of Sh 2–104 will help identify the nature of the X-ray sources and their relation to MGRO J2019+37. We also show that the putative VERITAS excess south of Sh 2–104, is most likely associated with the newly discovered Fermi pulsar PSR J2017+3625 and not the H ii region.

  10. Gradients in microbial methanol uptake: productive coastal upwelling waters to oligotrophic gyres in the Atlantic Ocean.

    PubMed

    Dixon, Joanna L; Sargeant, Stephanie; Nightingale, Philip D; Colin Murrell, J

    2013-03-01

    Methanol biogeochemistry and its importance as a carbon source in seawater is relatively unexplored. We report the first microbial methanol carbon assimilation rates (k) in productive coastal upwelling waters of up to 0.117±0.002 d(-1) (~10 nmol l(-1 )d(-1)). On average, coastal upwelling waters were 11 times greater than open ocean northern temperate (NT) waters, eight times greater than gyre waters and four times greater than equatorial upwelling (EU) waters; suggesting that all upwelling waters upon reaching the surface (≤20 m), contain a microbial population that uses a relatively high amount of carbon (0.3-10 nmol l(-1 )d(-1)), derived from methanol, to support their growth. In open ocean Atlantic regions, microbial uptake of methanol into biomass was significantly lower, ranging between 0.04-0.68 nmol l(-1 )d(-1). Microbes in the Mauritanian coastal upwelling used up to 57% of the total methanol for assimilation of the carbon into cells, compared with an average of 12% in the EU, and 1% in NT and gyre waters. Several methylotrophic bacterial species were identified from open ocean Atlantic waters using PCR amplification of mxaF encoding methanol dehydrogenase, the key enzyme in bacterial methanol oxidation. These included Methylophaga sp., Burkholderiales sp., Methylococcaceae sp., Ancylobacter aquaticus, Paracoccus denitrificans, Methylophilus methylotrophus, Methylobacterium oryzae, Hyphomicrobium sp. and Methylosulfonomonas methylovora. Statistically significant correlations for upwelling waters between methanol uptake into cells and both chlorophyll a concentrations and methanol oxidation rates suggest that remotely sensed chlorophyll a images, in these productive areas, could be used to derive total methanol biological loss rates, a useful tool for atmospheric and marine climatically active gas modellers, and air-sea exchange scientists. PMID:23178665

  11. Gradients in microbial methanol uptake: productive coastal upwelling waters to oligotrophic gyres in the Atlantic Ocean.

    PubMed

    Dixon, Joanna L; Sargeant, Stephanie; Nightingale, Philip D; Colin Murrell, J

    2013-03-01

    Methanol biogeochemistry and its importance as a carbon source in seawater is relatively unexplored. We report the first microbial methanol carbon assimilation rates (k) in productive coastal upwelling waters of up to 0.117±0.002 d(-1) (~10 nmol l(-1 )d(-1)). On average, coastal upwelling waters were 11 times greater than open ocean northern temperate (NT) waters, eight times greater than gyre waters and four times greater than equatorial upwelling (EU) waters; suggesting that all upwelling waters upon reaching the surface (≤20 m), contain a microbial population that uses a relatively high amount of carbon (0.3-10 nmol l(-1 )d(-1)), derived from methanol, to support their growth. In open ocean Atlantic regions, microbial uptake of methanol into biomass was significantly lower, ranging between 0.04-0.68 nmol l(-1 )d(-1). Microbes in the Mauritanian coastal upwelling used up to 57% of the total methanol for assimilation of the carbon into cells, compared with an average of 12% in the EU, and 1% in NT and gyre waters. Several methylotrophic bacterial species were identified from open ocean Atlantic waters using PCR amplification of mxaF encoding methanol dehydrogenase, the key enzyme in bacterial methanol oxidation. These included Methylophaga sp., Burkholderiales sp., Methylococcaceae sp., Ancylobacter aquaticus, Paracoccus denitrificans, Methylophilus methylotrophus, Methylobacterium oryzae, Hyphomicrobium sp. and Methylosulfonomonas methylovora. Statistically significant correlations for upwelling waters between methanol uptake into cells and both chlorophyll a concentrations and methanol oxidation rates suggest that remotely sensed chlorophyll a images, in these productive areas, could be used to derive total methanol biological loss rates, a useful tool for atmospheric and marine climatically active gas modellers, and air-sea exchange scientists.

  12. Influence of poor effort on self-reported symptoms and neurocognitive test performance following mild traumatic brain injury.

    PubMed

    Lange, Rael T; Iverson, Grant L; Brooks, Brian L; Rennison, V Lynn Ashton

    2010-11-01

    When considering a diagnosis of postconcussion syndrome, clinicians must systematically evaluate and eliminate the possible contribution of many differential diagnoses, comorbidities, and factors that may cause or maintain self-reported symptoms long after mild traumatic brain injury (MTBI). One potentially significant contributing factor is symptom exaggeration. The purpose of the study is to examine the influence of poor effort on self-reported symptoms (postconcussion symptoms and cognitive complaints) and neurocognitive test performance following MTBI. The MTBI sample consisted of 63 referrals to a concussion clinic, evaluated within 5 months post injury (M = 2.0, SD = 1.0, range = 0.6-4.6), who were receiving financial compensation from the Workers' Compensation Board. Participants completed the Post-Concussion Scale (PCS), British Columbia Cognitive Complaints Inventory (BC-CCI), selected tests from the Neuropsychological Assessment Battery Screening Module (S-NAB), and the Test of Memory Malingering (TOMM). Participants were divided into two groups based on TOMM performance (15 fail, 48 pass). There were significant main effects and large effect sizes for the PCS (p = .002, d = 0.79) and BC-CCI (p = .011, d = 0.98) total scores. Patients in the TOMM fail group scored higher than those in the TOMM pass group on both measures. Similarly, there were significant main effects and/or large effect sizes on the S-NAB. Patients in the TOMM fail group performed more poorly on the Attention (p = .004, d = 1.26), Memory (p = .006, d = 1.16), and Executive Functioning (p > .05, d = 0.70) indexes. These results highlight the importance of considering the influence of poor effort, in conjunction with a growing list of factors that can influence, maintain, and/or mimic the persistent postconcussion syndrome. PMID:20437284

  13. Complement C3 Is the Strongest Predictor of Whole-Body Insulin Sensitivity in Psoriatic Arthritis

    PubMed Central

    D’Angelo, Salvatore; Russo, Emilio; Nicolosi, Kassandra; Gallucci, Antonio; Chiaravalloti, Agostino; Bruno, Caterina; Naty, Saverio; De Sarro, Giovambattista; Olivieri, Ignazio; Grembiale, Rosa Daniela

    2016-01-01

    Objectives To evaluate the correlation between inflammatory measures and whole-body insulin sensitivity in psoriatic arthritis (PsA) patients. Methods For the present study, 40 nondiabetic PsA patients were recruited. A standard oral glucose tolerance test (OGTT) was performed. The insulin sensitivity index (ISI), insulinogenic index (IGI) and oral disposition index (ODI) were calculated from dynamic values of glucose and insulin obtained during OGTT. Results In our study population, mean ISI was 3.5 ± 2.5, median IGI was 1.2 (0.7–1.8), mean ODI 4.5 ± 4.5. In univariate correlation analysis, ISI correlated inversely with systolic blood pressure (sBP) (R = -0.52, p = 0.001), diastolic blood pressure (dBP) (R = -0.45, p = 0.004) and complement C3 (R = -0.43, p = 0.006) and ODI correlated inversely with sBP (R = -0.38, p = 0.02), dBP (R = -0.35, p = 0.03) and complement C3 (R = -0.37, p = 0.02). No significant correlations were found between analyzed variables and IGI. In a stepwise multiple regression, only complement C3 entered in the regression equation and accounted for approximately 50% of the variance of ISI. Using a receiver operating characteristic (ROC) curve we identified the best cut-off for complement C3 of 1.32 g/L that yielded a sensitivity of 56% and a specificity of 96% for classification of insulin resistant patients. Conclusions In conclusion, our data suggest that serum complement C3 could represent a useful marker of whole-body insulin sensitivity in PsA patients. PMID:27656896

  14. Does a Non-Circular Chainring Improve Performance in the Bicycle Motocross Cycling Start Sprint?

    PubMed Central

    Mateo-March, Manuel; Fernández-Peña, Eneko; Blasco-Lafarga, Cristina; Morente-Sánchez, Jaime; Zabala, Mikel

    2014-01-01

    Maximising power output during the initial acceleration phase of a bicycle motocross (BMX) race increases the chance to lead the group for the rest of the race. The purpose of this study was to investigate the effect of non-circular chainrings (Q-ring) on performance during the initial acceleration phase of a BMX race. Sixteen male cyclists (Spanish National BMX team) performed two counterbalanced and randomized initial sprints (3.95s), using Q- ring vs. circular chainring, on a BMX track. The sample was divided into two different groups according to their performance (Elite; n = 8 vs. Cadet; n = 8). Elite group covered a greater distance using Q-ring (+0.26 m, p = 0.02; D = 0.23), whilst the improvement for the Cadet (+0.04 m) was not significant (p = 0.87; D = -0.02). Also, there was no significant difference in power output for the Elite group, while the Cadet group revealed larger peak power with the circular chainring. Neither lactate level, nor heart rate showed significant differences due to the different chainring used. The non-circular chainring improved the initial acceleration capacity only in the Elite riders. Key Points This work provides novel results demonstrating very significant improvements in the sprint performance of BMX cycling discipline using a non-circular chainring system. This study seeks a practical application from scientific analysis All data are obtained in a real context of high competition using a sample comprised by the National Spanish Team. Some variables influencing performance as subjects’ physical fitness are discussed. Technical equipment approved by International Cycling Union is studied to check its potentially beneficial influence on performance. PMID:24570612

  15. The effects of fluid ingestion on free-paced intermittent-sprint performance and pacing strategies in the heat.

    PubMed

    Skein, Melissa; Duffield, Rob

    2010-02-01

    The purpose of this study was to examine the effects of fluid ingestion on pacing strategies and performance during intermittent-sprint exercise in the heat. Nine male rugby players performed a habituation session and 2 x 50-min intermittent-sprint protocols at a temperature of 31 degrees C, either with or without fluid. Participants were informed of a third session (not performed) to ensure that they remained blind to all respective conditions. The protocol consisted of a 15-m sprint every minute separated by self-paced bouts of hard running, jogging, and walking for the remainder of the minute. Sprint time, distance covered during self-paced exercise, and vertical jump height before and after exercise were recorded. Heart rate, core temperature, nude mass, capillary blood haematocrit, pH, lactate concentration, perceptual ratings of perceived exertion, thermal stress, and thirst were also recorded. Sprint times (fluid vs. no-fluid: 2.82 +/- 0.11 vs. 2.82 +/- 0.14) and distance covered during self-paced exercise (fluid vs. no-fluid: 4168 +/- 419 vs. 3981 +/- 263 m) were not different between conditions (P = 0.10-0.98) but were progressively reduced to a greater extent in the no-fluid trial (7 +/- 13%) (d = 0.56-0.58). There were no differences (P = 0.22-1.00; d = <0.20-0.84) between conditions in any physiological measures. Perceptual ratings of perceived exertion and thermal stress did not differ between conditions (P = 0.34-0.91; d < or =0.20-0.48). Rating of thirst after exercise was lower in the fluid trial (P = 0.02; d = 0.62-0.73). The present results suggest that fluid availability did not improve intermittent-sprint performance, however did affect pacing strategies with a greater reduction in distance covered of self-paced exercise during the no-fluid trial. PMID:20077276

  16. Transfer of Cs-137 from grass and wilted grass silage to milk of dairy cows.

    PubMed

    Vreman, K; van der Struijs, T D; van den Hoek, J; Berende, P L; Goedhart, P W

    1989-09-01

    Deposition of radiocaesium from the Chernobyl reactor accident on the Netherlands made it possible to collect contaminated fresh grass and first cut wilted grass silage. These contaminated roughages were used in transfer experiments with lactating dairy cows to determine transfer coefficients and half-lives for Cs-137 in milk. The experimental design was based on three consecutive periods: a preliminary period to determine the background concentration of the isotope in milk, a contamination period to determine the magnitude of accumulation and finally a depletion period to measure the rate at which the activity concentration of Cs-137 in milk declined after continuous feeding. The average transfer coefficient (Fmilk) for cows fed on contaminated dried grass under steady-state conditions was 0.002 d/kg and for cows fed on slightly contaminated second cut fresh grass 0.006 d/kg. The highest transfer coefficients were obtained for cows fed on contaminated grass silage for 119 days, which also included the dry period of about two months. For the first five days after calving the Fmilk values varied from 0.0066 to 0.0091 d/kg. There were no significant differences in transfer coefficients between cows in early lactation (third month of lactation), cows in late lactation (the last month of the lactation period) and cows fed on both contaminated grass silage and uncontaminated maize silage simultaneously. Half-life values for the rate of decline of the isotope in milk during the depletion period were estimated on the basis of a mathematical model with two exponential components. These components were characterized by half-lives of 0.5 to 3.5 days and 10 to 46 days.

  17. Kava in the treatment of generalized anxiety disorder: a double-blind, randomized, placebo-controlled study.

    PubMed

    Sarris, Jerome; Stough, Con; Bousman, Chad A; Wahid, Zahra T; Murray, Greg; Teschke, Rolf; Savage, Karen M; Dowell, Ashley; Ng, Chee; Schweitzer, Isaac

    2013-10-01

    Kava (Piper methysticum) is a plant-based medicine, which has been previously shown to reduce anxiety. To date, however, no placebo-controlled trial assessing kava in the treatment of generalized anxiety disorder (GAD) has been completed. A total of 75 participants with GAD and no comorbid mood disorder were enrolled in a 6-week double-blind trial of an aqueous extract of kava (120/240 mg of kavalactones per day depending on response) versus placebo. γ-Aminobutyric acid (GABA) and noradrenaline transporter polymorphisms were also analyzed as potential pharmacogenetic markers of response. Reduction in anxiety was measured using the Hamilton Anxiety Rating Scale (HAMA) as the primary outcome. Intention-to-treat analysis was performed on 58 participants who met inclusion criteria after an initial 1 week placebo run-in phase. Results revealed a significant reduction in anxiety for the kava group compared with the placebo group with a moderate effect size (P = 0.046, Cohen d = 0.62). Among participants with moderate to severe Diagnostic and Statistical Manual of Mental Disorders-diagnosed GAD, this effect was larger (P = 0.02; d = 0.82). At conclusion of the controlled phase, 26% of the kava group were classified as remitted (HAMA ≤ 7) compared with 6% of the placebo group (P = 0.04). Within the kava group, GABA transporter polymorphisms rs2601126 (P = 0.021) and rs2697153 (P = 0.046) were associated with HAMA reduction. Kava was well tolerated, and aside from more headaches reported in the kava group (P = 0.05), no other significant differences between groups occurred for any other adverse effects, nor for liver function tests. Standardized kava may be a moderately effective short-term option for the treatment of GAD. Furthermore, specific GABA transporter polymorphisms appear to potentially modify anxiolytic response to kava.

  18. Groundwater remediation by an in situ biobarrier: a bench scale feasibility test for methyl tert-butyl ether and other gasoline compounds.

    PubMed

    Saponaro, Sabrina; Negri, Marco; Sezenna, Elena; Bonomo, Luca; Sorlini, Claudia

    2009-08-15

    Most gasoline contains high percentages of methyl tert-butyl ether (MTBE) as an additive. The physico-chemical properties of this substance (high water solubility, low sorption in soil) result in high mobility and dissolved concentrations in soil. In situ permeable biological barriers (biobarriers, BBs) can remediate MTBE polluted groundwater by allowing pure cultures or microbial consortia to degrade MTBE when aerobic conditions are present, either by direct metabolism or cometabolism. Lab-scale batch and column tests were carried out to assess a selected microbial consortium in biodegrading MTBE and other gasoline compounds (benzene B, toluene T, ethylbenzene E, xylenes X) and to measure the parameters affecting the efficacy of a BB treatment of polluted groundwater. During the aerobic phase of the batch tests, the simultaneous biodegradation of MTBE, tert-butyl alcohol (TBA), B, T, E and o-X was observed. The rapid biodegradation of BTEXs resulted in decreased oxygen availability, but MTBE degradation was nevertheless measured in the presence of BTEXs. Stationary concentrations of MTBE and TBA were measured when anoxic conditions occurred in the systems. Values for a first order kinetic removal process were obtained for MTBE (0.031+/-0.001 d(-1)), B (0.045+/-0.002 d(-1)) and T (0.080+/-0.004 d(-1)) in the inoculated column tests. The estimate of the BB design parameters suggested that inoculation could significantly modify (double) the longitudinal dispersivity value of the biomass support medium. No effect was observed in the retardation factors for MTBE, B and T. PMID:19200654

  19. Shape, thermal and surface properties determination of a candidate spacecraft target asteroid (175706) 1996 FG3

    NASA Astrophysics Data System (ADS)

    Yu, LiangLiang; Ji, Jianghui; Wang, Su

    2014-04-01

    In this paper, a 3D convex shape model of (175706) 1996 FG3, which consists of 2040 triangle facets and 1022 vertices, is derived from the known light curves. The best-fitting orientation of the asteroid's spin axis is determined to be λ = 237.27° and β = -83.8° considering the observation uncertainties, and its rotation period is ˜3.5935 h. Using the derived shape model, we adopt the so-called advanced thermophysical model (ATPM) to fit three published sets of mid-infrared observations of 1996 FG3, so as to evaluate its surface properties. Assuming the primary and the secondary bear identical shape, albedo, thermal inertia and surface roughness, the best-fitting parameters are obtained from the observations. The geometric albedo and effective diameter of the asteroid are reckoned to be pv = 0.045 ± 0.002, D_eff=1.69^{+0.05}_{-0.02} km. The diameters of the primary and secondary are determined to be D1=1.63^{+0.04}_{-0.03} km and D2=0.45^{+0.04}_{-0.03} km, respectively. The surface thermal inertia Γ is derived to be a low value of 80 ± 40 Jm-2 s-0.5 K-1 with a roughness fraction fR of 0.8^{+0.2}_{-0.4}. This indicates that the primary possibly has a regolith layer on its surface, which is likely to be covered by a mixture of dust, fragmentary rocky debris and sand. The minimum regolith depth is estimated to be 5-20 mm from the simulations of subsurface temperature distribution, indicating that 1996 FG3 could be a very suitable target for a sample return mission.

  20. Is balance exercise training as effective as aerobic exercise training in fibromyalgia syndrome?

    PubMed

    Duruturk, Neslihan; Tuzun, Emine Handan; Culhaoglu, Belde

    2015-05-01

    The aim was to compare the effect of aerobic and balance exercises on pain severity, myalgic score, quality of life, exercise capacity and balance in fibromyalgia syndrome (FMS). A total of 33 females diagnosed with FMS by the American College of Rheumatology criteria were recruited in this randomised controlled study and allocated to aerobic exercise (AE) or balance exercise (BE) groups. Exercises were performed three times a week, for 6 weeks on a treadmill or with a Tetrax interactive balance system (TIBS). Outcome measures were characterised by myalgic score, visual analogue scale, Fibromyalgia Impact Questionnaire (FIQ), exercise testing, Timed Up-Go (TUG) and TIBS measurements. Comparisons from baseline to 6 weeks were evaluated using Wilcoxon test. Mann-Whitney U test was used to compare differences between groups. Effect sizes were also calculated. Improvements in pain, myalgic score and FIQ were found in both groups (p < 0.05). While comparing groups, myalgic score was significant (p = 0.02, d = -1.77), the value was higher in AE. Exercise duration, Borg scale, resting blood pressures (RBP) and maximal heart rate were significant in AE. In BE, Borg scale, exercise duration was significant (p < 0.05). While comparing groups, diastolic RBP (p = 0.04, d = -0.92), exercise duration (p = 0.00, d = -1.64) were significant, with higher values in AE. TUG significantly changed in groups (p < 0.05, d ≥ -1.22). Stability scores, eyes open while standing on elastic pads (p = 0.00, d = -0.98) and head back (p = 0.03, d = -0.74), were significant, with higher values in BE. This study showed that BE provided some improvements in FMS, but AE training led to greater gains. BE training should be included in comprehensive programs. PMID:25903448

  1. The yield and decay coefficients of exoelectrogenic bacteria in bioelectrochemical systems.

    PubMed

    Wilson, Erica L; Kim, Younggy

    2016-05-01

    In conventional wastewater treatment, waste sludge management and disposal contribute the major cost for wastewater treatment. Bioelectrochemical systems, as a potential alternative for future wastewater treatment and resources recovery, are expected to produce small amounts of waste sludge because exoelectrogenic bacteria grow on anaerobic respiration and form highly populated biofilms on bioanode surfaces. While waste sludge production is governed by the yield and decay coefficient, none of previous studies have quantified these kinetic constants for exoelectrogenic bacteria. For yield coefficient estimation, we modified McCarty's free energy-based model by using the bioanode potential for the free energy of the electron acceptor reaction. The estimated true yield coefficient ranged 0.1 to 0.3 g-VSS (volatile suspended solids) g-COD(-1) (chemical oxygen demand), which is similar to that of most anaerobic microorganisms. The yield coefficient was sensitively affected by the bioanode potential and pH while the substrate and bicarbonate concentrations had relatively minor effects on the yield coefficient. In lab-scale experiments using microbial electrolysis cells, the observed yield coefficient (including the effect of cell decay) was found to be 0.020 ± 0.008 g-VSS g-COD(-1), which is an order of magnitude smaller than the theoretical estimation. Based on the difference between the theoretical and experimental results, the decay coefficient was approximated to be 0.013 ± 0.002 d(-1). These findings indicate that bioelectrochemical systems have potential for future wastewater treatment with reduced waste sludge as well as for resources recovery. Also, the found kinetic information will allow accurate estimation of wastewater treatment performance in bioelectrochemical systems. PMID:26963605

  2. Mindfulness Training in Primary Schools Decreases Negative Affect and Increases Meta-Cognition in Children

    PubMed Central

    Vickery, Charlotte E.; Dorjee, Dusana

    2016-01-01

    Studies investigating the feasibility and impact of mindfulness programs on emotional well-being when delivered by school teachers in pre-adolescence are scarce. This study reports the findings of a controlled feasibility pilot which assessed acceptability and emotional well-being outcomes of an 8-week mindfulness program (Paws b) for children aged 7–9 years. The program was delivered by school teachers within a regular school curriculum. Emotional well-being was measured using self-report questionnaires at baseline, post-training and 3 months follow-up, and informant reports were collected at baseline and follow-up. Seventy one participants aged 7–9 years were recruited from three primary schools in the UK (training group n = 33; control group n = 38). Acceptability of the program was high with 76% of children in the training group reporting ‘liking’ practicing mindfulness at school, with a strong link to wanting to continue practicing mindfulness at school (p < 0.001). Self-report comparisons revealed that relative to controls, the training group showed significant decreases in negative affect at follow-up, with a large effect size (p = 0.010, d = 0.84). Teacher reports (but not parental ratings) of meta-cognition also showed significant improvements at follow-up with a large effect size (p = 0.002, d = 1.08). Additionally, significant negative correlations were found between changes in mindfulness and emotion regulation scores from baseline to post-training (p = 0.038) and baseline to follow-up (p = 0.033). Findings from this study provide initial evidence that the Paws b program in children aged 7–9 years (a) can be feasibly delivered by primary school teachers as part of the regular curriculum, (b) is acceptable to the majority of children, and (c) may significantly decrease negative affect and improve meta-cognition. PMID:26793145

  3. Effects of exercise training and Mediterranean diet on vascular risk reduction in post-menopausal women.

    PubMed

    Alkhatib, Ahmad; Klonizakis, Markos

    2014-01-01

    This study tested the potential risk-reduction benefits of Mediterranean Diet (MD) and regular exercise training on microvascular activity and cardiorespiratory capacity in postmenopausal women. Fifteen sedentary postmenopausal participants (age = 54.6 ± 3.6) were randomised into either exercise training or exercise combined with following MD for eight-weeks, and were assessed for their cardiorespiratory capacity, and upper- and lower-limb endothelial cutaneous vascular conductance (CVC) test using Laser Doppler Fluximetry (LDF), coupled with measuring endothelium-dependent Acetylcholine Chloride (Ach) and -dependent Sodium Nitropurruside (SNP) vasodilators. Exercise training improved cardiorespiratory capacity as indicated by ventilatory threshold (11.5 ± 2.1 vs. 14.0 ± 3.0 ml·kg-1·min-1, p < 0.05) and improved the microcirculatory perfusion results of CVC for both vasodilators Ach (p < 0.001, d = 0.65) and SNP (p = 0.003, d = 0.53) in the lower-limb and ACh (p = 0.01, d = 0.41) and SNP (p = 0.03, d = 0.48) in the upper-limb, all (p < 0.05). However, combining exercise with MD showed a stronger improvement in Ach (p = 0.02, d = 0.36) of the lower limb, than in exercise alone group. The results suggest that regular moderate exercise improves microcirculatory vascular function and increases exercise tolerance, both are responsible for reducing cardiovascular risk in postmenopausal women. However, combining MD with exercise suggests additional microvascular vasodialiatory improvement, suggesting an effective strategy for further cardiovascular risk-reduction in this high-risk group.

  4. Measuring rates of biodegradation in a contaminated aquifer using field and laboratory methods

    USGS Publications Warehouse

    Chapelle, F.H.; Bradley, P.M.; Lovley, D.R.; Vroblesky, D.A.

    1996-01-01

    Rates of biodegradation were measured in a petroleum hydrocarbon-contaminated aquifer using a combination of field and laboratory methods. These methods are based on tracking concentration changes of substrates (both electron donors and acceptors) or final products of microbial metabolism over time. Ground water at the study site (Hanahan, South Carolina) is anoxic, and sulfate reduction it the predominant terminal electron accepting process. Laboratory studies conducted with sediment cored from the site showed that 14C-toluene was mineralized to 14CO2 with a first-order degradation rate constant (ktol) of- 0.01 d-1 under sulfate-reducing conditions. Under nitrate-amended, Fe(III)-amended, or nonamended (methanogenic) conditions, toluene was not significantly mineralized. 14C-Benzene was degraded at low but measurable rates (kbrn= 0.003 d-1) under sulfate-reducing conditions whereas degradation under methanogenic conditions was negligible. These results illustrate the extreme sensitivity of laboratory-measured biodegradation rates to terminal electron-accepting conditions, and show the necessity of carefully matching experimental conditions to in situ conditions. Concentration decreases of toluene along aquifer flowpaths, when the uncertainty of ground-water flow velocities was considered, indicated ktol values ranging from -0.0075 to -0.03 d-1. Concentration decreases of sulfate and concentration increase of dissolved inorganic carbon (DIC), when normalized for assumed stoichiometric oxidation of toluene coupled to sulfate reduction, yielded a kso4 range of -0.005 to -0.02 d-1, and a kDIC value range of +0.00075 to -0.003 d-1. Because both laboratory and field methods have numerous sources of uncertainty, a combination of these methods is the most appropriate procedure for evaluating biodegradation rate constants in contaminated ground-water systems.

  5. Groundwater remediation by an in situ biobarrier: a bench scale feasibility test for methyl tert-butyl ether and other gasoline compounds.

    PubMed

    Saponaro, Sabrina; Negri, Marco; Sezenna, Elena; Bonomo, Luca; Sorlini, Claudia

    2009-08-15

    Most gasoline contains high percentages of methyl tert-butyl ether (MTBE) as an additive. The physico-chemical properties of this substance (high water solubility, low sorption in soil) result in high mobility and dissolved concentrations in soil. In situ permeable biological barriers (biobarriers, BBs) can remediate MTBE polluted groundwater by allowing pure cultures or microbial consortia to degrade MTBE when aerobic conditions are present, either by direct metabolism or cometabolism. Lab-scale batch and column tests were carried out to assess a selected microbial consortium in biodegrading MTBE and other gasoline compounds (benzene B, toluene T, ethylbenzene E, xylenes X) and to measure the parameters affecting the efficacy of a BB treatment of polluted groundwater. During the aerobic phase of the batch tests, the simultaneous biodegradation of MTBE, tert-butyl alcohol (TBA), B, T, E and o-X was observed. The rapid biodegradation of BTEXs resulted in decreased oxygen availability, but MTBE degradation was nevertheless measured in the presence of BTEXs. Stationary concentrations of MTBE and TBA were measured when anoxic conditions occurred in the systems. Values for a first order kinetic removal process were obtained for MTBE (0.031+/-0.001 d(-1)), B (0.045+/-0.002 d(-1)) and T (0.080+/-0.004 d(-1)) in the inoculated column tests. The estimate of the BB design parameters suggested that inoculation could significantly modify (double) the longitudinal dispersivity value of the biomass support medium. No effect was observed in the retardation factors for MTBE, B and T.

  6. Hard X-Ray Emission from Sh 2-104: A NuSTAR Search for Gamma-Ray Counterparts

    NASA Astrophysics Data System (ADS)

    Gotthelf, E. V.; Mori, K.; Aliu, E.; Paredes, J. M.; Tomsick, J. A.; Boggs, S. E.; Christensen, F. E.; Craig, W. W.; Hailey, C. J.; Harrison, F. A.; Hong, J. S.; Rahoui, F.; Stern, D.; Zhang, W. W.

    2016-07-01

    We present NuSTAR hard X-ray observations of Sh 2-104, a compact H ii region containing several young massive stellar clusters (YMSCs). We have detected distinct hard X-ray sources coincident with localized VERITAS TeV emission recently resolved from the giant gamma-ray complex MGRO J2019+37 in the Cygnus region. Fainter, diffuse X-rays coincident with the eastern YMSC in Sh2-104 likely result from the colliding winds of a component star. Just outside the radio shell of Sh 2-104 lies 3XMM J201744.7+365045 and a nearby nebula, NuSTAR J201744.3+364812, whose properties are most consistent with extragalactic objects. The combined XMM-Newton and NuSTAR spectrum of 3XMM J201744.7+365045 is well-fit to an absorbed power-law model with {N}{{H}}=(3.1+/- 1.0)× {10}22 cm-2 and a photon index {{Γ }}=2.1+/- 0.1. Based on possible long-term flux variation and the lack of detected pulsations (≤43% modulation), this object is likely a background active galactic nucleus rather than a Galactic pulsar. The spectrum of the NuSTAR nebula shows evidence of an emission line at E = 5.6 keV, suggesting an optically obscured galaxy cluster at z = 0.19 ± 0.02 (d = 800 Mpc) and L X = 1.2 × 1044 erg s-1. Follow-up Chandra observations of Sh 2-104 will help identify the nature of the X-ray sources and their relation to MGRO J2019+37. We also show that the putative VERITAS excess south of Sh 2-104, is most likely associated with the newly discovered Fermi pulsar PSR J2017+3625 and not the H ii region.

  7. Bathymetry and Composition of Titan's Hydrocarbon Seas from the Cassini RADAR Altimeter

    NASA Astrophysics Data System (ADS)

    Mastrogiuseppe, Marco; Hayes, Alex; Poggiali, Valerio; Lunine, Jonathan; Seu, Roberto; Hofgartner, Jason; Le Gall, Alice; Lorenz, Ralph

    2016-04-01

    The Cassini RADAR's altimetry mode has been successfully used for probing the depth and composition of Titan's hydrocarbons seas. In May 2013, during the spacecraft's T91 flyby of Titan, the instrument demonstrated its capabilities as a radar sounder, presenting a unique opportunity to constraint the depth and composition of Titan's second largest sea, Ligeia Mare. Later, observations of Kraken Mare and Punga Mare were planned and executed in August 2014 (T104) and January 2015 (T108), respectively. While most of the seafloor was not detected at Kraken, suggesting the sea was either too deep or too absorptive in these areas to observe a return from the seafloor, shallow areas near Moray Sinus did show subsurface reflections. At Punga Mare, a clear detection of the subsurface was observed with a maximum depth of 120 m along the radar altimetry transect. Herein we present a re-analysis of altimetry data acquired over Ligeia Mare and, earlier in the Cassini mission (in December 2008 during T49), over the southern Ontario Lacus. Depths measurements and liquid composition are obtained using a novel technique which makes use of radar simulations and Monte Carlo-based inversions. Simulation is based on a two-layer model, where the surface is represented by a specular reflection and the seafloor is modeled using a facet-based synthetic surface, including thermal noise, speckle effects, analog to digital conversion (ADC), block adaptive quantization (BAQ), and allows for possible receiver saturation. This new analysis provides an update to the Ku-band attenuation (the Cassini RADAR operates at a wavelength of 2 cm) and results in a new estimate for loss tangent and composition. We found a value of specific attenuation of the liquid equal to 0.14±0.02 dB/m and 0.2±0.1 dB/m, which is equivalent to a loss tangent of 4.4±0.9x10^-5 and 7±3x10^-5 for Ligeia Mare and Ontario Lacus, respectively. Assuming that Titan's liquid bodies are composed by a ternary mixture of methane, ethane, and nitrogen, these values of loss tangent are consistent with a composition of 69% of methane (CH4), 14% of ethane (C2H6) and 17% nitrogen (N2) for Ligeia Mare and 47% of methane (CH4), 40% of ethane (C2H6) and 13% nitrogen (N2) for Ontario Lacus.

  8. Effect of sire on mu- and m-calpain activity and rate of tenderization as indicated by myofibril fragmentation indices of steaks from Brahman cattle.

    PubMed

    Riley, D G; Chase, C C; Pringle, T D; West, R L; Johnson, D D; Olson, T A; Hammond, A C; Coleman, S W

    2003-10-01

    The objectives of this study were to assess the influence of sire on mu- and m-calpain activities, to evaluate the relationships of activities of these enzymes to other traits related to beef palatability, and to assess the influence of sire on the rate of tenderization (as measured by myofibril fragmentation index [MFI]) in Brahman longissimus muscle. Brahman calves (n = 87), sired by nine bulls, were born, weaned, fed, and slaughtered in central Florida. Traits evaluated were mu- and m-calpain activities and MFI after 1, 7, 14, and 21 d of aging. Other traits were analyzed to determine their associations with mu- and m-calpain activity and MFI, including calpastatin activity, percentage of raw and cooked lipids, Warner-Bratzler shear force (WBSF) values after 7, 14, and 21 d of aging, and sensory panel rating of tenderness, juiciness, and connective tissue amount after 14 d of aging. Data were analyzed using a model with sire, sex, year, and slaughter group (calves of the same sex slaughtered on the same date) as fixed effects, and adjusted to a constant adjusted 12th-rib fat thickness. Sire affected mu-calpain activity (P < 0.04), calpastatin activity (P < 0.01), d-14 MFI (P < 0.02), d-7 WBSF (P < 0.05), d-14 WBSF (P < 0.04), and sensory panel juiciness score (P < 0.01), but not (P < 0.75) m-calpain activity. Measures of tenderness and palatability were generally moderately to strongly correlated (both simple and residual correlations) with calpastatin and m-calpain activity. Myofibril fragmentation index residuals (adjusted for all model components except sire) after all aging periods were fitted using nonlinear regression to the exponential curve (MFI(i) = kappa0 + kappa1 exp[kappa2 t(i)] + epsilon(i), where t(i) represents aging in days, k0 is ultimate MFI after aging, kappa1 is the difference between initial and ultimate MFI, kappa2 is the rate of increase in MFI, and epsilon(i) is the error term associated with the ith observation, assumed to be independent and identically distributed normally). Sires had different estimates and combinations of estimates, which were used to plot MFI change with time. These curves visually differed for sires and suggested that postmortem tenderization extent and rate differ as well. Use of a combination of these estimated parameters in a selection/carcass sorting program represents an alternative consideration for tenderization improvement programs. PMID:14552370

  9. The HARPS search for southern extra-solar planets. XXXVI. Planetary systems and stellar activity of the M dwarfs GJ 3293, GJ 3341, and GJ 3543

    NASA Astrophysics Data System (ADS)

    Astudillo-Defru, N.; Bonfils, X.; Delfosse, X.; Ségransan, D.; Forveille, T.; Bouchy, F.; Gillon, M.; Lovis, C.; Mayor, M.; Neves, V.; Pepe, F.; Perrier, C.; Queloz, D.; Rojo, P.; Santos, N. C.; Udry, S.

    2015-03-01

    Context. Planetary companions of a fixed mass induce reflex motions with a larger amplitude around lower-mass stars, which adds to making M dwarfs excellent targets for extra-solar planet searches. The most recent velocimeters with a stability of ~1 m s-1 can detect very low-mass planets out to the habitable zone of these stars. Low-mass small planets are abundant around M dwarfs, and most of the known potentially habitable planets orbit one of these cool stars. Aims: Our M-dwarf radial velocity monitoring with HARPS on the ESO 3.6 m telescope at La Silla observatory makes a major contribution to this sample. Methods: We present here dense radial velocity (RV) time series for three M dwarfs observed over ~five years: GJ 3293 (0.42 M⊙), GJ 3341 (0.47 M⊙), and GJ 3543 (0.45 M⊙). We extracted these RVs through minimum χ2-matching of each spectrum against a stack of all observed spectra for the same star that has a high signal-to-noise ratio. We then compared potential orbital signals against several stellar activity indicators to distinguish the Keplerian variations induced by planets from the spurious signals that result from rotational modulation of stellar surface inhomogeneities and from activity cycles. Results: Two Neptune-mass planets - msin(i) = 1.4 ± 0.1 and 1.3 ± 0.1Mnept - orbit GJ 3293 with periods P = 30.60 ± 0.02 d and P = 123.98 ± 0.38 d, possibly together with a super-Earth - msin(i) ~ 7.9 ± 1.4 M⊕ - with period P = 48.14 ± 0.12d. A super-Earth - msin(i) ~ 6.1 M⊕ - orbits GJ 3341 with P = 14.207 ± 0.007d. The RV variations of GJ 3543, on the other hand, reflect its stellar activity rather than planetary signals. Based on observations made with the HARPS instrument on the ESO 3.6 m telescope under the program IDs 072.C-0488, 082.C-0718 and 183.C-0437 at Cerro La Silla (Chile).Tables A.1-A.3 (radial velocity data) are available in electronic form at http://www.aanda.org and at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (ftp://130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/575/A119

  10. A Dosimetric Comparison between Conventional Fractionated and Hypofractionated Image-guided Radiation Therapies for Localized Prostate Cancer

    PubMed Central

    Li, Ming; Li, Gao-Feng; Hou, Xiu-Yu; Gao, Hong; Xu, Yong-Gang; Zhao, Ting

    2016-01-01

    Background: Image-guided radiation therapy (IGRT) is the preferred method for curative treatment of localized prostate cancer, which could improve disease outcome and reduce normal tissue toxicity reaction. IGRT using cone-beam computed tomography (CBCT) in combination with volumetric-modulated arc therapy (VMAT) potentially allows smaller treatment margins and dose escalation to the prostate. The aim of this study was to compare the difference of dosimetric diffusion in conventional IGRT using 7-field, step-and-shoot intensity-modulated radiation therapy (IMRT) and hypofractionated IGRT using VMAT for patients with localized prostate cancer. Methods: We studied 24 patients who received 78 Gy in 39 daily fractions or 70 Gy in 28 daily fractions to their prostate with/without the seminal vesicles using IMRT (n = 12) or VMAT (n = 12) for prostate cancer between November 2013 and October 2015. Image guidance was performed using kilovoltage CBCT scans equipped on the linear accelerator. Offline planning was performed using the daily treatment images registered with simulation computed tomography (CT) images. A total of 212 IMRT plans in conventional cohort and 292 VMAT plans in hypofractionated cohort were enrolled in the study. Dose distributions were recalculated on CBCT images registered with the planning CT scanner. Results: Compared with 7-field, step-and-shoot IMRT, VMAT plans resulted in improved planning target volume (PTV) D95% (7663.17 ± 69.57 cGy vs. 7789.17 ± 131.76 cGy, P < 0.001). VMAT reduced the rectal D25 (P < 0.001), D35 (P < 0.001), and D50 (P < 0.001), bladder V50 (P < 0.001), D25 (P = 0.002), D35 (P = 0.028), and D50 (P = 0.029). However, VMAT did not statistically significantly reduce the rectal V50, compared with 7-field, step-and-shoot IMRT (25.02 ± 5.54% vs. 27.43 ± 8.79%, P = 0.087). Conclusions: To deliver the hypofractionated radiotherapy in prostate cancer, VMAT significantly increased PTV D95% dose and decreased the dose of radiation

  11. Life Span Exercise Among Elite Intercollegiate Student Athletes

    PubMed Central

    Sorenson, Shawn C.; Romano, Russell; Azen, Stanley P.; Schroeder, E. Todd; Salem, George J.

    2015-01-01

    Background: Despite prominent public attention, data on life span health and exercise outcomes among elite, competitive athletes are sparse and do not reflect the diversity of modern athletes. Hypothesis: Life span exercise behavior differs between National Collegiate Athletic Association (NCAA) student athletes and a nonathlete control group. Sustained exercise is associated with improved cardiopulmonary health outcomes. Study Design: Cross-sectional, descriptive epidemiology study. Level of Evidence: Level 3. Methods: A total of 496 students and alumni (age range, 17-84 year) at a large, NCAA Division I university, including student athletes and an age- and sex-matched nonathlete control group, completed anonymous, self-report health and exercise questionnaires. Age-stratified, cross-sectional analysis evaluated previous week’s total exercise volume (ExVol), self-rated exercise importance (ExImp), and compliance with American College of Sports Medicine (ACSM) exercise guidelines for healthy adults. The association of ACSM guideline compliance with lifetime cardiopulmonary health outcomes was also assessed. Results: Current student athletes reported significantly greater ExVol (P < 0.001. Cohen d = 0.99, probability of clinically important difference [pCID] >99.5%), ExImp (P < 0.001, d = 1.96, pCID = 96%), and likelihood of compliance with ACSM guidelines (odds ratio [OR], 95% confidence interval [CI] = 30.6, 11.0-84.6) compared with nonathletes. No significant differences were found between alumni student athletes and nonathletes. Alumni student athletes demonstrated substantially lower ExVol (P < 0.001, d = –0.94, pCID >99.5%) and guideline compliance (OR = 0.09, 95% CI = 0.05-0.19) compared with current student athletes, whereas nonathletes had similar exercise behavior across the life span. Among alumni, ACSM guideline compliance was associated with significant attenuation of cardiopulmonary health concerns (P = 0.02, d = –0.50, pCID = 14%) independent of intercollegiate athletic participation. Conclusion: Although current NCAA Division I student athletes demonstrated significant, clinically important differences in exercise behavior compared with nonathletes, no group differences were evident later in life. Irrespective of collegiate athletic status, healthy exercise behavior among alumni was associated with cardiopulmonary health benefits. Clinical Relevance: To realize life span health benefits, it is imperative that student athletes maintain consistent patterns of healthy exercise beyond retirement from competitive sports. PMID:25553217

  12. Long-term far-transfer effects of working memory training in children with ADHD: a randomized controlled trial.

    PubMed

    Bigorra, Aitana; Garolera, Maite; Guijarro, Silvina; Hervás, Amaia

    2016-08-01

    ADHD affects working memory (WM) and other executive functions (EFs) and thereby negatively impacts school performance, clinical symptoms and functional impairment. The main aim of this study was to analyse the efficacy of computerized WM training (CWMT) on EF rating scales. A secondary objective was to assess its efficacy on performance-based measures of EF (PBMEF), learning, clinical symptoms and functional impairment. 66 children with combined-type ADHD between 7 and 12 years of age from the Child and Adolescent Psychiatric Unit (Spain) were included in this randomized, double-blind, placebo-controlled, parallel-group clinical trial. The participants were randomized (1:1) to an experimental group (EG) (CWMT) (n = 36) or a control group (CG) (placebo training). Assessments were conducted at baseline (T0), 1-2 weeks (T1), and 6 months post-intervention (T2) with the administration of EF rating scales, PBMEF, measures of academic achievement, and questionnaires regarding clinical symptoms and functional impairment. Participants, parents, teachers and professionals who performed the cognitive assessments were blinded. Adjusted multiple linear regression analysis showed significant improvements in EF scales-parent version, from T1 to T2, on the metacognition index [p = 0.03, d' = -0.78 (95 % CI -1.28 to -0.27)] and on WM (also significant at T2-T0) and plan/organize subscales. Significant improvements were also noted in EF scales-teacher version, from T0 to T1 and T2, on the metacognitive index [p = 0.05, d' = -0.37 (95 % CI -0.86 to 0.12) T1-T0, p = 0.02, d' = -0.81 (95 % CI -1.31 to -0.30) T2-T0] and on the initiate, WM, monitor and shift subscales. There were also significant improvements in PBMEF, ADHD symptoms, and functional impairment. CWMT had a significant impact on ADHD deficits by achieving long-term far-transfer effects. PMID:26669692

  13. VARIABLE STARS IN THE GLOBULAR CLUSTER NGC 2808

    SciTech Connect

    Kunder, Andrea; Walker, Alistair R.; Stetson, Peter B.; Catelan, Marcio; Amigo, Pia E-mail: mcatelan@astro.puc.cl

    2013-02-01

    The first calibrated broadband BVI time-series photometry is presented for the variable stars in NGC 2808, with observations spanning a range of 28 years. We have also redetermined the variability types and periods for the variable stars identified previously by Corwin et al., revising the number of probable fundamental-mode RR Lyrae variables (RR0) to 11 and the number of first-overtone variables (RR1) to five. Our observations were insufficient to discern the nature of the previously identified RR1 star, V24, and the tentatively identified RR1 star, V13. These two variables are {approx}0.8 mag brighter than the RR Lyrae variables, appear to have somewhat erratic period and/or luminosity changes, and lie inside the RR Lyrae instability strip. Curiously, all but one of the RR Lyrae stars studied in this relatively metal-rich cluster exhibit the Blazhko phenomenon, an effect thought to occur with higher frequency in metal-poor environments. The mean periods of the RR0 and RR1 variables are (P){sub RR0} = 0.56 {+-} 0.01 d and

    {sub RR1} = 0.30 {+-} 0.02 d, respectively, supporting an Oosterhoff I classification of the cluster. On the other hand, the number ratio of RR1-to-RR0-type variables is high, though not unprecedented, for an Oosterhoff I cluster. The RR Lyrae variables have no period shifts at a given amplitude compared to the M3 variables, making it unlikely that these variables are He enhanced. Using the recent recalibration of the RR Lyrae luminosity scale by Catelan and Cortes, a mean distance modulus of (m - M){sub V} = 15.57 {+-} 0.13 mag for NGC 2808 is obtained, in good agreement with that determined here from its type II Cepheid and SX Phoenicis population. Our data have also allowed the discovery of two new candidate SX Phoenicis stars and an eclipsing binary in the blue straggler region of the NGC 2808 color-magnitude diagram.

  14. Effects of multi-ingredient supplementation on resistance training in young males.

    PubMed

    Willems, Mark Et; Sallis, Chris W; Haskell, Jonathan A

    2012-06-01

    Muscle strength and fatigue resistance increases with resistance training. Resistance training adaptations can be enhanced with single-ingredient or dual-ingredient supplementation but less is known about resistance training adaptations by multi-ingredient supplementation. We examined the effects of a commercial multi-ingredient supplement on resistance training adaptations for training-specific and non-training-specific tasks in young males. Male participants (n = 16, age 21±2 years, body mass 74.5±5.9 kg, body height 177±5 cm) had at least 1 year experience with resistance training exercises. Training (7 muscle groups, 4 sessions/week, weekly adjustments) consisted of two 6 weeks blocks with 4 weeks between blocks. During training, participants consumed placebo (i.e. maltodextrin, n = 7) or the sports nutritional supplement Cyclone (Maximuscle Ltd, UK, n = 9) (main ingredients creatine monohydrate, whey protein, glutamine and HMB) twice daily with one intake <15 min following a training session. Unpaired Student's t-test was used for placebo and Cyclone group comparison of percentage changes with p < 0.05. Effect sizes (Cohen's d) were calculated for the Cyclone group. Cyclone did not enhance maximal voluntary isometric force (MVIF) (p = 0.56), time to fatigue at 70% MVIF (p = 0.41) and peak concentric strength (60°·s(-1)) (p = 0.66) of m.quadriceps femoris (i.e. the non-specific training tasks). For the specific-training tasks, Cyclone did not enhance one-repetition maximum (1-RM) of lateral pull (p = 0.48) but there was a trend and large effect size for 1-RM of bench press (p = 0.07, d = 0.98) and 45° leg press (p = 0.07, d = 1.41). Cyclone resulted in an increase in number of repetitions for 80% pre-training 1-RM for lateral pull (p = 0.02, d = 1.30), bench press (p = 0.03, d = 1.20) with a trend for 45° leg press (p = 0.08, d = 0.96). Cyclone during resistance training enhanced the performance of 1-RM and number of repetitions at 80% of pre-training 1RM of some training-specific tasks, all with large effect sizes. Our observations suggest that Cyclone during resistance training substantially improves the ability to perform training-related tasks. PMID:23487491

  15. Properties of diphytanoyl phospholipids at the air-water interface.

    PubMed

    Yasmann, Anthony; Sukharev, Sergei

    2015-01-01

    Diphytanoylphosphatidyl choline (DPhPC) is a synthetic ester lipid with methylated tails found in archaeal ether lipids. Because of the stability of DPhPC bilayers and the absence of phase transitions over a broad range of temperatures, the lipid is used as an artificial membrane matrix for the reconstitution of channels, pumps, and membrane-active peptides. We characterized monomolecular films made of DPhPC and its natural ether analog DOPhPC at the air-water interface. We measured compression isotherms and dipole potentials of films made of DPhPC, DPhPE, and DOPhPC. We determined that at 40 mN/m the molecular area of DPhPC is 81.2 Å(2), consistent with X-ray and neutron scattering data obtained in liposomes. This indicates that 40 mN/m is the monolayer-bilayer equivalence pressure for this lipid. At this packing density, the compressibility modulus (Cs(-1 )= 122 ± 7 mN/m) and interfacial dipole potential (V = 355 ± 16 mV) were near their maximums. The molecular dipole moment was estimated to be 0.64 ± 0.02 D. The ether DOPhPC compacted to 70.4 Å(2)/lipid at 40 mN/m displaying a peak compressibility similar to that of DPhPC. The maximal dipole potential of the ether lipid was about half of that for DPhPC at this density, and the elemental dipole moment was about a quarter. The spreading of DPhPC and DOPhPC liposomes reduced the surface tension of the aqueous phase by 46 and 49 mN/m, respectively. This corresponds well to the monolayer collapse pressure. The equilibration time shortened as the temperature increased from 20 to 60 °C, but the surface pressure at equilibrium did not change. The data illustrates the properties of branched chains and the contributions of ester bonds in setting the mechanical and electrostatic parameters of diphytanoyl lipids. These properties determine an environment in which reconstituted voltage- or mechano-activated proteins may function. Electrostatic properties are important in the preparation of asymmetric folded bilayers, whereas lateral compressibility defines the tension in mechanically stimulated droplet interface bilayers.

  16. Video-based instructions for surgical hand disinfection as a replacement for conventional tuition? A randomised, blind comparative study

    PubMed Central

    Weber, Uwe; Constantinescu, Mihai A.; Woermann, Ulrich; Schmitz, Felix; Schnabel, Kai

    2016-01-01

    Introduction: Various different learning methods are available for planning tuition regarding the introduction to surgical hand disinfection. These learning methods should help to organise and deal with this topic. The use of a video film is an alternative to conventional tuition due to the real presentation possibilities of practical demonstration. Objective: This study examines by way of comparison which form of communication is more effective for learning and applying surgical hand disinfection for medical students in their first year of studies: video-based instruction or conventional tuition. Methodology: A total of 50 first-year medical students were randomly allocated either to the “Conventional Instruction” (CI) study group or to the “Video-based Instruction” (VI) study group. The conventional instruction was carried out by an experienced nurse preceptor/nurse educator for the operating theatre who taught the preparatory measures and the actual procedure in a two-minute lesson. The second group watched a two-minute video sequence with identical content. Afterwards, both groups demonstrated practically the knowledge they had acquired at an individual practical test station. The quality (a) of the preparation and (b) of the procedure as well as (c) the quality of the results was assessed by 6 blind experts using a check list. The acceptability of the respective teaching method was also asked about using a questionnaire. Results: The group performance did not differ either in the preparation (t=-78, p<0.44) or in the quality (t=-99, p<0.34). With respect to performance, it was possible to demonstrate a strong treatment effect. In the practical (t=-3.33, p<0.002, d=0.943) and in the total score (t=-2.65, p<0.011, d=0.751), the group with video-based instruction achieved a significantly better result. In response to the question as to which of the two learning methods they would prefer, the significant majority (60.4%) of students stated video

  17. HD 144548: A young triply eclipsing system in the Upper Scorpius OB association

    NASA Astrophysics Data System (ADS)

    Alonso, R.; Deeg, H. J.; Hoyer, S.; Lodieu, N.; Palle, E.; Sanchis-Ojeda, R.

    2015-12-01

    The star HD 144548 (=HIP 78977; TYP 6212-1273-1) has been known as a detached eclipsing binary and a bona-fide member of the Upper Scorpius OB association. Continuous photometry from the K2 mission on Campaign Two has revealed the presence of additional eclipses due to the presence of a third star in the system. These are explained by a system composed of the two previously known members of the eclipsing system (Ba and Bb) with a period of 1.63 d, orbiting around an F7-F8V star with a period of 33.945 ± 0.002 d in an eccentric orbit (eA = 0.2652 ± 0.0003). The timing of the eclipses of Ba and Bb reveals the same 33.9 d periodicity, which we interpret as the combination of a light time effect combined with dynamical perturbations on the close system. Here we combine radial velocities and analytical approximations for the timing of the eclipses to derive masses and radii for the three components of the system. We obtain a mass of 1.44 ± 0.04 M⊙ and radius of 2.41 ± 0.03 R⊙ for the A component, and almost identical masses and radii of about 0.96 M⊙ and 1.33 R⊙ for each of the two components of the close binary. HD 144548 is the first triply eclipsing system for which radial velocities of all components could be measured. Partially based on observations made with the Italian Telescopio Nazionale Galileo (TNG) operated by the Fundación Galileo Galilei of the INAF, the Nordic Optical Telescope, operated by the Nordic Optical Telescope Scientific Association, and the William Herschel Telescope (programme DDT58 - PI Lodieu) operated by the Isaac Newton Group on the island of La Palma at the Spanish Observatorio Roque de los Muchachos of the IAC. This paper includes data collected by the Kepler mission. Funding for the Kepler mission is provided by the NASA Science Mission directorate.Appendices are available in electronic form at http://www.aanda.org

  18. Long-term far-transfer effects of working memory training in children with ADHD: a randomized controlled trial.

    PubMed

    Bigorra, Aitana; Garolera, Maite; Guijarro, Silvina; Hervás, Amaia

    2016-08-01

    ADHD affects working memory (WM) and other executive functions (EFs) and thereby negatively impacts school performance, clinical symptoms and functional impairment. The main aim of this study was to analyse the efficacy of computerized WM training (CWMT) on EF rating scales. A secondary objective was to assess its efficacy on performance-based measures of EF (PBMEF), learning, clinical symptoms and functional impairment. 66 children with combined-type ADHD between 7 and 12 years of age from the Child and Adolescent Psychiatric Unit (Spain) were included in this randomized, double-blind, placebo-controlled, parallel-group clinical trial. The participants were randomized (1:1) to an experimental group (EG) (CWMT) (n = 36) or a control group (CG) (placebo training). Assessments were conducted at baseline (T0), 1-2 weeks (T1), and 6 months post-intervention (T2) with the administration of EF rating scales, PBMEF, measures of academic achievement, and questionnaires regarding clinical symptoms and functional impairment. Participants, parents, teachers and professionals who performed the cognitive assessments were blinded. Adjusted multiple linear regression analysis showed significant improvements in EF scales-parent version, from T1 to T2, on the metacognition index [p = 0.03, d' = -0.78 (95 % CI -1.28 to -0.27)] and on WM (also significant at T2-T0) and plan/organize subscales. Significant improvements were also noted in EF scales-teacher version, from T0 to T1 and T2, on the metacognitive index [p = 0.05, d' = -0.37 (95 % CI -0.86 to 0.12) T1-T0, p = 0.02, d' = -0.81 (95 % CI -1.31 to -0.30) T2-T0] and on the initiate, WM, monitor and shift subscales. There were also significant improvements in PBMEF, ADHD symptoms, and functional impairment. CWMT had a significant impact on ADHD deficits by achieving long-term far-transfer effects.

  19. Comorbid Anxiety and Social Avoidance in Treatment of Severe Childhood Aggression: Response to Adding Risperidone to Stimulant and Parent Training; Mediation of Disruptive Symptom Response

    PubMed Central

    Gadow, Kenneth D.; Farmer, Cristan A.; Findling, Robert L.; Bukstein, Oscar; Molina, Brooke S.G.; Brown, Nicole V.; Li, Xiaobai; Rundberg-Rivera, E. Victoria; Bangalore, Srihari; Buchan-Page, Kristin; Hurt, Elizabeth A.; Rice, Robert; McNamara, Nora K.; Aman, Michael G.

    2015-01-01

    Abstract Objective: In the four-site Treatment of Severe Childhood Aggression (TOSCA) study, addition of risperidone to stimulant and parent training moderately improved parent-rated disruptive behavior disorder (DBD) symptoms. This secondary study explores outcomes other than DBD and attention-deficit/hyperactivity disorder (ADHD) as measured by the Child and Adolescent Symptom Inventory-4R (CASI-4R). Methods: A total of 168 children ages 6–12 with severe aggression (physical harm), DBD, and ADHD were randomized to parent training plus stimulant plus placebo (basic treatment) or parent training plus stimulant plus risperidone (augmented treatment) for 9 weeks. All received only parent training plus stimulant for the first 3 weeks, then those with room for improvement received a second drug (placebo or risperidone) for 6 weeks. CASI-4R category item means at baseline and week 9 were entered into linear mixed-effects models for repeated measures to evaluate group differences in changes. Mediation of the primary DBD outcome was explored. Results: Parent ratings were nonsignificant with small/negligible effects, but teacher ratings (n=46 with complete data) showed significant augmented treatment advantage for symptoms of anxiety (p=0.013, d=0.71), schizophrenia spectrum (p=0.017, d=0.45), and impairment in these domains (p=0.02, d=0.26), all remaining significant after false discovery rate correction for multiple tests. Improvement in teacher-rated anxiety significantly (p=0.001) mediated the effect of risperidone augmentation on the primary outcome, the Disruptive-total of the parent-rated Nisonger Child Behavior Rating Form. Conclusions: Addition of risperidone to parent training plus stimulant improves not only parent-rated DBD as previously reported, but also teacher-rated anxiety–social avoidance. Improvement in anxiety mediates improvement in DBD, suggesting anxiety-driven fight-or-flight disruptive behavior with aggression, with implications for potential treatment strategies. Clinicians should attend to possible anxiety in children presenting with aggression and DBD. Clinical Trial Registry: Treatment of Severe Childhood Aggression (The TOSCA Study). NCT00796302. clinicaltrials.gov. PMID:25885010

  20. Profil épidémiologique de l'infection à VIH au cours d'une campagne de sensibilisation à Yaoundé au Cameroun

    PubMed Central

    Mbopi-Keou, Francois-Xavier; Nguefack-Tsague, Georges; Kalla, Ginette Claude Mireille; Viche, Lade; Noubom, Michel

    2013-01-01

    Introduction L'objectif de ce travail était de déterminer le profil épidémiologique de l'infection à VIH/SIDA au cours d'une campagne de sensibilisation à Yaoundé au Cameroun. Méthodes Après avoir obtenu le consentement éclairé des participants, le dépistage de l'infection par le VIH a été effectué selon l'algorithme de dépistage en série de l'Organisation Mondiale de la Santé (OMS). En outre, un questionnaire socio-comportemental a été proposé à chaque participant. Résultats Au total, 911 personnes ont été dépistées. La prévalence de l'infection par le VIH était de 2.6%. Elle était 3 fois plus élevée parmi les femmes (RC = 3.22, IC (1.26 - 8.18). Les prévalences les plus élevées ont été observées chez les personnes de plus de 45 ans (p = 0.01), les personnes sans emploi (p < 0.001) et les veufs/veuves (p = 0.02). Plus de 80% des participants trouvaient le test de dépistage nécessaire et 76,2% l'avaient déjà effectué au moins une fois auparavant. Il s'agissait principalement de femmes (p = 0.02), d'étudiants (p < 0.001) et des personnes âgées de 25 à 34 ans (p < 0.001). Les personnes séropositives avaient moins tendance à retirer leur résultat (p = 0.01). Conclusion Il apparait urgent d'intensifier les campagnes de dépistage de l'infection par le VIH en ciblant davantage des groupes particuliers tels que les élèves, les personnes âgées et les veufs/veuves, tout en recherchant les facteurs pouvant favoriser la propagation de l'infection dans ces groupes. PMID:24255725

  1. Effects of strengthening and stretching exercise programmes on kinematics and kinetics of running in older adults: a randomised controlled trial.

    PubMed

    Fukuchi, Reginaldo K; Stefanyshyn, Darren J; Stirling, Lisa; Ferber, Reed

    2016-09-01

    The aim of this study was to investigate the effects of strengthening and stretching exercises on running kinematics and kinetics in older runners. One hundred and five runners (55-75 years) were randomly assigned to either a strengthening (n = 36), flexibility (n = 34) or control (n = 35) group. Running kinematics and kinetics were obtained using an eight-camera system and an instrumented treadmill before and after the eight-week exercise protocol. Measures of strength and flexibility were also obtained using a dynamometer and inclinometer/goniometer. A time effect was observed for the excursion angles of the ankle sagittal (P = 0.004, d = 0.17) and thorax/pelvis transverse (P < 0.001, d = 0.20) plane. Similarly, a time effect was observed for knee transverse plane impulse (P = 0.013, d = 0.26) and ground reaction force propulsion (P = 0.042, d = -0.15). A time effect for hip adduction (P = 0.006, d = 0.69), ankle dorsiflexion (P = 0.002, d = 0.47) and hip internal rotation (P = 0.048, d = 0.30) flexibility, and hip extensor (P = 0.001, d = -0.48) and ankle plantar flexor (P = 0.01, d = 0.39) strength were also observed. However, these changes were irrespective of exercise group. The results of the present study indicate that an eight-week stretching or strengthening protocol, compared to controls, was not effective in altering age-related running biomechanics despite changes in ankle and trunk kinematics, knee kinetics and ground reaction forces along with alterations in muscle strength and flexibility were observed over time. PMID:26805699

  2. A Ka-Band Wide-Bandgap Solid-State Power Amplifier: Architecture Performance Estimates

    NASA Technical Reports Server (NTRS)

    Epp, L.; Khan, P.; Silva, A.

    2005-01-01

    Motivated by recent advances in wide-bandgap (WBG) gallium nitride (GaN) semiconductor technology, there is considerable interest in developing efficient solidstate power amplifiers (SSPAs) as an alternative to the traveling-wave tube amplifier (TWTA) for space applications. This article documents the results of a study to investigate power-combining technology and SSPA architectures that can enable a 120-W, 40 percent power-added efficiency (PAE) SSPA. Results of the study indicate that architectures based on at least three power combiner designs are likely to enable the target SSPA. The proposed architectures can power combine 16 to 32 individual monolithic microwave integrated circuits (MMICs) with >80 percent combining efficiency. This corresponds to MMIC requirements of 5- to 10-W output power and >48 percent PAE. For the three proposed architectures [1], detailed analysis and design of the power combiner are presented. The first architecture studied is based on a 16-way septum combiner that offers low loss and high isolation over the design band of 31 to 36 GHz. Analysis of a 2-way prototype septum combiner had an input match >25 dB, output match >30 dB, insertion loss <0.02 dB, and isolation >30 dB over the design band. A 16-way design, based on cascading this combiner in a binary fashion, is documented. The second architecture is based on a 24-way waveguide radial combiner. A prototype 24-way radial base was analyzed to have an input match >30 dB (under equal excitation of all input ports). The match of the mode transducer that forms the output of a radial combiner was found to be >27 dB. The functional bandwidth of the radial base and mode transducer, which together will form a radial combiner/divider, exceeded the design band. The third architecture employs a 32-way, parallel-plate radial combiner. Simulation results indicated an input match >24 dB, output match >22 dB, insertion loss <0.23 dB, and adjacent port isolation >20 dB over the design band. All three architectures utilize a low-loss MMIC amplifier module based on commercial MMIC packaging and a custom microstrip-to-rectangular-waveguide transition. The insertion loss of the module is expected to be 0.45 dB over the design band.

  3. The effect of an acute sleep hygiene strategy following a late-night soccer match on recovery of players.

    PubMed

    Fullagar, Hugh; Skorski, Sabrina; Duffield, Rob; Meyer, Tim

    2016-01-01

    Elite soccer players are at risk of reduced recovery following periods of sleep disruption, particularly following late-night matches. It remains unknown whether improving sleep quality or quantity in such scenarios can improve post-match recovery. Therefore, the aim of this study was to investigate the effect of an acute sleep hygiene strategy (SHS) on physical and perceptual recovery of players following a late-night soccer match. In a randomised cross-over design, two highly-trained amateur teams (20 players) played two late-night (20:45) friendly matches against each other seven days apart. Players completed an SHS after the match or proceeded with their normal post-game routine (NSHS). Over the ensuing 48 h, objective sleep parameters (sleep duration, onset latency, efficiency, wake episodes), countermovement jump (CMJ; height, force production), YoYo Intermittent Recovery test (YYIR2; distance, maximum heart rate, lactate), venous blood (creatine kinase, urea and c-reactive protein) and perceived recovery and stress markers were collected. Sleep duration was significantly greater in SHS compared to NSHS on match night (P = 0.002, d = 1.50), with NSHS significantly less than baseline (P < 0.001, d = 1.95). Significant greater wake episodes occurred on match night for SHS (P = 0.04, d = 1.01), without significant differences between- or within-conditions for sleep onset latency (P = 0.12), efficiency (P = 0.39) or wake episode duration (P = 0.07). No significant differences were observed between conditions for any physical performance or venous blood marker (all P > 0.05); although maximum heart rate during the YYIR2 was significantly higher in NSHS than SHS at 36 h post-match (P = 0.01; d = 0.81). There were no significant differences between conditions for perceptual "overall recovery" (P = 0.47) or "overall stress" (P = 0.17). Overall, an acute SHS improved sleep quantity following a late-night soccer match; albeit without any improvement in physical

  4. Daily acute intermittent hypoxia elicits functional recovery of diaphragm and inspiratory intercostal muscle activity after acute cervical spinal injury

    PubMed Central

    Navarrete-Opazo, A.; Vinit, S; Dougherty, B.J.; Mitchell, G.S.

    2015-01-01

    A major cause of mortality after spinal cord injury is respiratory failure. In normal rats, acute intermittent hypoxia (AIH) induces respiratory motor plasticity, expressed as diaphragm (Dia) and second external intercostal (T2 EIC) long-term facilitation (LTF). Dia (not T2 EIC) LTF is enhanced by systemic adenosine 2A (A2a) receptor inhibition in normal rats. We investigated the respective contributions of Dia and T2 EIC to daily AIH-induced functional recovery of breathing capacity with/without A2a receptor antagonist (KW6002, i.p.) following C2 hemisection (C2HS). Rats received daily AIH (dAIH: 10, 5-min episodes, 10.5% O2; 5-min normoxic intervals; 7 successive days beginning 7 days post-C2HS) or daily normoxia (dNx) with/without KW6002, followed by weekly (reminder) presentations for 8 weeks. Ventilation and EMGs from bilateral diaphragm and T2 EIC muscles were measured with room air breathing (21% O2) and maximum chemoreceptor stimulation (MCS: 7% CO2, 10.5% O2). dAIH increased tidal volume (Vt) in C2HS rats breathing room air (dAIH + vehicle: 0.47 ± 0.02, dNx + vehicle: 0.40 ± 0.01ml/100 g; p<0.05) and MCS (dAIH + vehicle: 0.83 ± 0.01, dNx + vehicle: 0.73 ± 0.01ml/100g; p<0.001); KW6002 had no significant effect. dAIH enhanced contralateral (uninjured) diaphragm EMG activity, an effect attenuated by KW6002, during room air breathing and MCS (p<0.05). Although dAIH enhanced contralateral T2 EIC EMG activity during room air breathing, KW6002 had no effect. dAIH had no statistically significant effects on diaphragm or T2 EIC EMG activity ipsilateral to injury. Thus, two weeks post-C2HS: 1) dAIH enhances breathing capacity by effects on contralateral diaphragm and T2 EIC activity; and 2) dAIH-induced recovery is A2a dependent in diaphragm, but not T2 EIC. Daily AIH may be a useful in promoting functional recovery of breathing capacity after cervical spinal injury, but A2a receptor antagonists (eg. caffeine) may undermine its effectiveness shortly after injury. PMID:25687551

  5. Mesozooplankton biomass and grazing responses to Cyclone Opal, a subtropical mesoscale eddy

    NASA Astrophysics Data System (ADS)

    Landry, Michael R.; Decima, Moira; Simmons, Melinda P.; Hannides, Cecelia C. S.; Daniels, Emy

    2008-05-01

    As part of E-Flux III cruise studies in March 2005, plankton net collections were made to assess the effects of a cyclonic cold-core eddy (Cyclone Opal) on the biomass and grazing of mesozooplankton. Mesozooplankton biomass in the central region of Cyclone Opal, an area of uplifted nutricline and a subsurface diatom bloom, averaged 0.80±0.24 and 1.51±0.59 g DW m -2, for day and night tows, respectively. These biomass estimates were about 80% higher than control (OUT) stations, with increases more or less proportionately distributed among size classes from 0.2 to >5 mm. Though elevated relative to surrounding waters south of the Hawaiian Islands (Hawai'i lee), total biomass and size distribution in Cyclone Opal were almost exactly the same as contemporary measurements made at Stn. ALOHA, 100 km north of the islands, by the HOT (Hawaii Ocean Time-series) Program. Mesozooplankton biomass and community composition at the OUT stations were also similar to ALOHA values from 1994 to 1996, preceding a recent decadal increase. These comparisons may therefore provide insight into production characteristics or biomass gradients associated with decadal changes at Stn. ALOHA. Gut fluorescence estimates were higher in Opal than in ambient waters, translating to grazing impacts of 0.11±0.02 d -1 (IN) versus 0.03±0.01 d -1 (OUT). Over the depth-integrated euphotic zone, mesozooplankton accounted for 30% of the combined grazing losses of phytoplankton to micro- and meso-herbivores in Opal, as compared to 13% at control stations. Estimates of active export flux by migrating zooplankton averaged 0.81 mmol C m -2 d -1 in Cyclone Opal and 0.37 mmol C m -2 d -1 at OUT stations, 53% and 24%, respectively, of the carbon export measured by passive sediment traps. Migrants also exported 0.18 mmol N m -2 d -1 (117% of trap N flux) in Cyclone Opal compared to 0.08 mmol N m -2 d -1 (51% of trap flux) at control stations. Overall, the food-web importance of mesozooplankton increased in Cyclone Opal both in absolute and relative terms. Diel migrants provided evidence for enhanced export flux in the eddy that was missed by sediment trap and 234Th techniques, and migrant-mediated flux was the major export term in the observed bloom-perturbation response and N mass balance of the eddy.

  6. Effect of sire on mu- and m-calpain activity and rate of tenderization as indicated by myofibril fragmentation indices of steaks from Brahman cattle.

    PubMed

    Riley, D G; Chase, C C; Pringle, T D; West, R L; Johnson, D D; Olson, T A; Hammond, A C; Coleman, S W

    2003-10-01

    The objectives of this study were to assess the influence of sire on mu- and m-calpain activities, to evaluate the relationships of activities of these enzymes to other traits related to beef palatability, and to assess the influence of sire on the rate of tenderization (as measured by myofibril fragmentation index [MFI]) in Brahman longissimus muscle. Brahman calves (n = 87), sired by nine bulls, were born, weaned, fed, and slaughtered in central Florida. Traits evaluated were mu- and m-calpain activities and MFI after 1, 7, 14, and 21 d of aging. Other traits were analyzed to determine their associations with mu- and m-calpain activity and MFI, including calpastatin activity, percentage of raw and cooked lipids, Warner-Bratzler shear force (WBSF) values after 7, 14, and 21 d of aging, and sensory panel rating of tenderness, juiciness, and connective tissue amount after 14 d of aging. Data were analyzed using a model with sire, sex, year, and slaughter group (calves of the same sex slaughtered on the same date) as fixed effects, and adjusted to a constant adjusted 12th-rib fat thickness. Sire affected mu-calpain activity (P < 0.04), calpastatin activity (P < 0.01), d-14 MFI (P < 0.02), d-7 WBSF (P < 0.05), d-14 WBSF (P < 0.04), and sensory panel juiciness score (P < 0.01), but not (P < 0.75) m-calpain activity. Measures of tenderness and palatability were generally moderately to strongly correlated (both simple and residual correlations) with calpastatin and m-calpain activity. Myofibril fragmentation index residuals (adjusted for all model components except sire) after all aging periods were fitted using nonlinear regression to the exponential curve (MFI(i) = kappa0 + kappa1 exp[kappa2 t(i)] + epsilon(i), where t(i) represents aging in days, k0 is ultimate MFI after aging, kappa1 is the difference between initial and ultimate MFI, kappa2 is the rate of increase in MFI, and epsilon(i) is the error term associated with the ith observation, assumed to be independent and identically distributed normally). Sires had different estimates and combinations of estimates, which were used to plot MFI change with time. These curves visually differed for sires and suggested that postmortem tenderization extent and rate differ as well. Use of a combination of these estimated parameters in a selection/carcass sorting program represents an alternative consideration for tenderization improvement programs.

  7. The impact of the oblateness of Regulus on the motion of its companion

    NASA Astrophysics Data System (ADS)

    Iorio, Lorenzo

    2008-11-01

    The fast spinning B-star Regulus has recently been found to be orbited by a fainter companion in a close circular path with orbital period P b=40.11(2) d. Being its equatorial radius R e 32% larger than the polar one R p, Regulus possesses a remarkable quadrupole mass moment Q. We investigate the effects of Q on the orbital period P b of its companion in order to see if they are measurable, given the present-day level of accuracy in measuring P b. Conversely, we will look for deviations from the third Kepler law, attributed to the quadrupole mass moment Q of Regulus, to constrain the ratio γ= m/ M of the system’s masses. The impact of Q on the orbital period is analytically worked out with a straightforward perturbative approach. The resulting correction P Q is compared to other competing dynamical effects. P Q and the Keplerian period P Kep are expressed in terms of the phenomenologically determined system’s parameters; γ is treated as an unknown. P Q is compared to the observational accuracy in measuring the orbital period δ P b=0.02 d and to the systematic uncertainty δ( P Kep) due to the errors in the system’s parameters entering it. The discrepancy Δ P=| P b- P Kep| is examined in order to see for which values of γ it becomes statistically significant. The physical meaning of the obtained range of values for γ is discussed in terms of Q. P Q is larger than δ P b but still smaller than the systematic uncertainty in P Kep by two orders of magnitude. The major sources of bias are the velocity semiamplitude K of the motion of the primary and its mass M. Assuming edge-on configuration, i.e. i=90 deg, if γ≳0.096 Q would be positive, i.e. Regulus would be prolate, contrary to the observations. If γ≲0.078 Q would be negative, but its magnitude would be one-two orders of magnitude larger than the approximate estimate Q≈ M( R {p/2}- R {e/2})=-2.4±0.5×1049 kg m2. Regulus is the first extrasolar binary system in which the orbital effects of the asphericity of the primary are larger than the observational sensitivity; moreover, no other competing aliasing orbital effects are present. Thus, it is desirable that it will become the object of future intensive observational campaigns in order to reduce the systematic uncertainty due to the system’s parameters below the measurability threshold.

  8. The very massive X-ray bright binary system Wack2134 (= WR21a)

    NASA Astrophysics Data System (ADS)

    Niemela, V. S.; Gamen, R. C.; Barbá, R. H.; Fernández Lajús, E.; Benaglia, P.; Solivella, G. R.; Reig, P.; Coe, M. J.

    2008-09-01

    From the radial velocities of the NIV λ4058 and HeII λ4686 emission lines, and the NV λ4604-20 absorption lines, determined in digital spectra, we report the discovery that the X-ray bright emission line star Wack2134 (= WR21a) is a spectroscopic binary system with an orbital period of 31.673 +/- 0.002d. With this period, the NIV and HeII emission and NV absorption lines, which originate in the atmosphere of the primary component, define a rather eccentric binary orbit (e = 0.64 +/- 0.03). The radial velocity variations of the NV absorptions have a lower amplitude than those of the HeII emission. Such a behaviour of the emission line radial velocities could be due to distortions produced by a superimposed absorption component from the companion. High-resolution echelle spectra observed during the quadrature phases of the binary show H and HeII absorptions of both components with a radial velocity difference of about 541kms-1. From this difference, we infer quite high values of the minimum masses, of about 87 and 53Msolar for the primary and secondary components, respectively, if the radial velocity variations of the HeII emission represent the true orbit of the primary. No HeI absorption lines are observed in our spectra. Thus, the secondary component in the Wack2134 binary system appears to be an early O-type star. From the presence of H, HeII and NV absorptions, and NIV and CIV emissions, in the spectrum of the primary component, it most clearly resembles those of Of/WNLha-type stars. Based partially on data collected at SAAO, CASLEO, LCO, CTIO and La Silla (under programme ID 68.D-0073) Observatories. In memoriam (1936-2006). ‡ E-mail: rgamen@casleo.gov.ar § Member of Carrera del Investigador CONICET, Argentina. Visiting Astronomer, Las Campanas Observatory and Cerro Tololo Inter-American Observatory, Chile, and CASLEO, Argentina. ¶ Member of Carrera del Investigador CONICET, Argentina. Visiting Astronomer, Las Campanas Observatory and Cerro Tololo Inter

  9. Compact trench based bend and splitter devices for silicon-on insulator rib waveguides

    NASA Astrophysics Data System (ADS)

    Qian, Yusheng

    Bends and splitters are typically the fundamental limiting waveguide components in reducing the size of planar lightwave circuits (PLCs) based on waveguides that have a low core/clad refractive index contrast, such as silicon-on-insulator (SOI) rib waveguides. This dissertation presents a solution to this problem in the form of trench-based bends (TBBs) and trench-based splitters (TBSs). Emphasis is placed on experimental demonstration of these components and their integration into practical devices exhibiting significant size reduction. First, a compact and low loss silicon-on-insulator rib waveguide 90° TBB is demonstrated based on an etched vertical interface and total internal reflection (TIR) realized by a trench filled with SU8. The measured loss for TE polarization is 0.32 dB +/- 0.02 dB/bend at a wavelength of 1.55 mum, which is the best reported in literature. Next, 90° TBSs are reported in which each splitter occupies an area of only 11 mum x 11 mum. These components require fabrication of trenches with a nearly 10:1 aspect ratio. A variety of single TBSs are fabricated having different trench widths. The relative amount of power directed into the transmission and reflection arms of the splitters is measured. The TBS reflection and transmission ratio agrees with three dimensional (3D) finite difference time domain (FDTD) predictions. An 82 nm wide trench filled with index matching fluid is experimentally shown to have a reflection/transmission splitting ratio of 49/51 at a wavelength of 1550 nm. To increase the fabrication yield of TBSs, the splitter angle is modified from 90° to 105°, which permits the trench width to be increased to 116 nm for a 50/50 splitter using SU8 as the trench fill material. The fabrication and measurement of compact 105° TBBs and TBSs are reported followed by their integration into 1 x 4, 1 x 8, and 1 x 32 trench-based splitter networks (TBSNs). The measured total optical loss of the 1 x 32 TBSN is 9.15 dB. Its size is only 700 mum x 1600 mum for an output waveguide spacing of 50 mum. Finally, a compact SOI trench-based ring resonator (TBRR) composed of 90° TBBs, TBSs, and rib waveguides is demonstrated. A TBRR with a ring circumference of 50 mum occupies an area of 20 x 20 mum. The free spectral range (FSR) is as large as 14 nm. By changing the trench fill material from SU8 (n = 1.57) to index fluid (n = 1.733), the peak wavelength can be shifted ~2 nm. Fabricated TBSNs and TBRRs demonstrate that large size reductions are possible for devices based on TBBs and TBSs. The net result is bend and splitter configurations with a size that is essentially independent of core/clad refractive index contrast. The approach developed in this dissertation is applicable to a wide range of waveguide material systems that have small core/clad refractive index contrast.

  10. INFLUENCE OF INJURY ON DYNAMIC POSTURAL CONTROL IN RUNNERS

    PubMed Central

    Klusendorf, Anna; Kernozek, Thomas

    2016-01-01

    ABSTRACT Background Injury has been linked with altered postural control in active populations. The association between running injury and dynamic postural control has not been examined. Hypothesis/Purpose The purpose of this study was to examine dynamic postural control in injured and uninjured runners using the Star Excursion Balance Test (SEBT), Time to Stabilization (TTS) of ground reaction forces following a single-leg landing, and postural stability indices reflecting the fluctuations in GRFs during single-leg landing and stabilization tasks (forward and lateral hop). It was hypothesized that dynamic postural control differences would exist between runners with a history of injury that interrupted training for ≥7 days (INJ) when compared to runners without injury (CON). Design Case-control study Methods Twenty-two INJ (14 F, 8 M; 23.7 ± 2.1 y; 22.3 ± 2.8 kg/m2; 29.5 ± 16.3 mi/wk) currently running > 50% pre-injury mileage without pain were compared with twenty-two matched CON (14F, 8M; 22.7 ± 1.2 y; 22.7 ± 2.7 kg/m2; 31.2 ± 19.6 mi/wk). INJ group was stratified by site of injury into two groups (Hip/Thigh/Knee and Lower Leg/Ankle/Foot) for secondary analysis. Leg length-normalized anterior, posterolateral, and posteromedial reach distances on the SEBT, medial/lateral and anterior/posterior ground reaction force TTS, directional postural stability indices, and a composite dynamic postural stability index (DPSI), were assessed using mixed model ANOVA (α=0.05) and effect sizes (d). Results No group X direction interaction or group differences were observed for the SEBT (p=0.51, 0.71) or TTS (p=0.83, 0.72) measures. A group X direction interaction was found for postural stability indices during the forward landing task (p<0.01). Both Hip/Thigh/Knee and Lower leg/Ankle/Foot INJ groups demonstrated a greater vertical postural stability index (VPSI) (p=0.01 for both, d=0.80, 0.95) and DPSI (p=0.01, 0.02, d=0.75, 0.93) when compared to CON suggesting impaired balance control. A group X direction interaction was also found for postural stability indices during the lateral landing task (p=0.03). Only the Hip/Thigh/Knee INJ runners displayed a greater VPSI (p=0.01, d=0.91) and DPSI (p=0.017, d=0.89) when compared to CON. Conclusions When compared to CON, INJ runners demonstrated impaired dynamic control of vertical forces when performing the single leg landing and stabilization tasks. Clinicians should consider addressing dynamic control of vertical loads through functional tasks during the rehabilitation of running injury. Level of Evidence Level 3 PMID:27274423

  11. The surprising magnetic topology of τ Sco: fossil remnant or dynamo output?

    NASA Astrophysics Data System (ADS)

    Donati, J.-F.; Howarth, I. D.; Jardine, M. M.; Petit, P.; Catala, C.; Landstreet, J. D.; Bouret, J.-C.; Alecian, E.; Barnes, J. R.; Forveille, T.; Paletou, F.; Manset, N.

    2006-08-01

    We report the discovery of a medium-strength (~0.5 kG) magnetic field on the young, massive star τ Sco (B0.2V), which becomes the third-hottest magnetic star known. Circularly polarized Zeeman signatures are clearly detected in observations collected mostly with the ESPaDOnS spectropolarimeter, recently installed on the 3.6-m Canada-France-Hawaii Telescope; temporal variability is also clearly established in the polarimetry, and can be unambiguously attributed to rotational modulation with a period close to 41 d. Archival ultraviolet (UV) spectra confirm that this modulation repeats over time-scales of decades, and refine the rotation period to 41.033 +/- 0.002 d. Despite the slow rotation rate of τ Sco, we none the less succeed in reconstructing the large-scale structure of its magnetic topology. We find that the magnetic structure is unusually complex for a hot star, with significant power in spherical-harmonic modes of degree up to 5. The surface topology is dominated by a potential field, although a moderate toroidal component is probably present. We fail to detect intrinsic temporal variability of the magnetic structure over the 1.5-yr period of our spectropolarimetric observations (in agreement with the stable temporal variations of the UV spectra), and infer that any differential surface rotation must be very small. The topology of the extended magnetic field that we derive from the photospheric magnetic maps is also more complex than a global dipole, and features in particular a significantly warped torus of closed magnetic loops encircling the star (tilted at about 90° to the rotation axis), with additional, smaller, networks of closed-field lines. This topology appears to be consistent with the exceptional X-ray properties of τ Sco and also provides a natural explanation of the variability observed in wind-formed UV lines. Although we cannot completely rule out the possibility that the field is produced through dynamo processes of an exotic kind, we

  12. Distribution of petroleum hydrocarbons and toluene biodegradation, Knox Street fire pits, Fort Bragg, North Carolina

    USGS Publications Warehouse

    Harden, S.L.; Landmeyer, J.E.

    1996-01-01

    ground-water toluene concentration data, a maximum rate constant for anaerobic biodegradation of toluene in the saturated zone was estimated to be as low as 0.002 d-1 or as high as 0.026 d-1. Based on analyses of ground-water/vapor samples, toluene was the prin- cipal TEX compound identified in ground water discharging to Beaver Creek. Observed decreases in ground-water/vapor toluene concentrations during the study period may reflect a decrease in source inputs, an increase in dilution caused by higher ground-water flow, and(or) removal by biological or other physical processes. Rate constants of toluene anaerobic biodegradation determined by laboratory measurements illustrate a typical acclimation response of micro-organisms to hydrocarbon contamination in sediments collected from the site. Toluene biodegradation rate constants derived from laboratory microcosm studies ranged from 0.001 to 0.027 d-1, which is similar to the range of 0.002 to 0.026 d-1 for toluene biodegradation rate constants derived from ground-water analytical data. The close agreement of toluene biodegradation rate constants reported using both approaches offer strong evidence that toluene can be degraded at environmentally significant rates at the study site.

  13. HADES RV program with HARPS-N at the TNG GJ 3998: An early M-dwarf hosting a system of super-Earths

    NASA Astrophysics Data System (ADS)

    Affer, L.; Micela, G.; Damasso, M.; Perger, M.; Ribas, I.; Suárez Mascareño, A.; González Hernández, J. I.; Rebolo, R.; Poretti, E.; Maldonado, J.; Leto, G.; Pagano, I.; Scandariato, G.; Zanmar Sanchez, R.; Sozzetti, A.; Bonomo, A. S.; Malavolta, L.; Morales, J. C.; Rosich, A.; Bignamini, A.; Gratton, R.; Velasco, S.; Cenadelli, D.; Claudi, R.; Cosentino, R.; Desidera, S.; Giacobbe, P.; Herrero, E.; Lafarga, M.; Lanza, A. F.; Molinari, E.; Piotto, G.

    2016-10-01

    Context. Many efforts are currently made to detect Earth-like planets around low-mass stars in almost every extra-solar planet search. M dwarfs are considered ideal targets for Doppler radial velocity searches because their low masses and luminosities make low-mass planets orbiting in these stars' habitable zones more easily detectable than those around higher mass stars. Nonetheless, the frequency statistics of low-mass planets hosted by low-mass stars remains poorly constrained. Aims: Our M-dwarf radial velocity monitoring with HARPS-N within the collaboration between the Global architectures of Planetary Systems (GAPS) project, the Institut de Ciències de l'Espai/CSIC-IEEC (ICE) and the Instituto de Astrofísica de Canarias (IAC) can provide a major contribution to the widening of the current statistics through the in-depth analysis of accurate radial velocity observations in a narrow range of spectral sub-types (79 stars, between dM0 to dM3). Spectral accuracy will enable us to reach the precision needed to detect small planets with a few Earth masses. Our survey will contribute to the surveys devoted to the search for planets around M-dwarfs, mainly focused on the M-dwarf population of the northern emisphere, for which we will provide an estimate of the planet occurrence. Methods: We present here a long-duration radial velocity monitoring of the M1 dwarf star GJ 3998 with HARPS-N to identify periodic signals in the data. Almost simultaneous photometric observations were carried out within the APACHE and EXORAP programs to characterize the stellar activity and to distinguish those due to activity and to the presence of planetary companions from the periodic signals. We ran a Markov chain Monte Carlo simulation and used a Bayesian model selection to determine the number of planets in this system, to estimate their orbital parameters and minimum mass, and to properly treat the activity noise. Results: The radial velocities have a dispersion in excess of their internal errors due to at least four superimposed signals with periods of 30.7, 13.7, 42.5, and 2.65 days. Our data are well described by a two-planet Keplerian (13.7 d and 2.65 d) and a fit with two sinusoidal functions (stellar activity, 30.7 d and 42.5 d). The analysis of spectral indexes based on Ca II H & K and Hα lines demonstrates that the periods of 30.7 and 42.5 days are due to chromospheric inhomogeneities modulated by stellar rotation and differential rotation. This result is supported by photometry and is consistent with the results on differential rotation of M stars obtained with Kepler. The shorter periods of 13.74 ± 0.02 d and 2.6498 ± 0.0008 d are well explained with the presence of two planets, with masses of at least 6.26-0.76+0.79 M⊕ and 2.47 ± 0.27 M⊕ and distances of 0.089 AU and 0.029 AU from the host, respectively. Based on: observations made with the Italian Telescopio Nazionale Galileo (TNG), operated on the island of La Palma by the INAF - Fundación Galileo Galilei at the Roche de Los Muchachos Observatory of the Instituto de Astrofísica de Canarias (IAC); photometric observations made with the APACHE array located at the Astronomical Observatory of the Aosta Valley; photometric observations made with the robotic telescope APT2 (within the EXORAP program) located at Serra La Nave on Mt. Etna. http://www.oact.inaf.it/exoit/EXO-IT/Projects/Entries/2011/12/27_GAPS.html

  14. HD 51844: An Am δ Scuti in a binary showing periastron brightening

    NASA Astrophysics Data System (ADS)

    Hareter, M.; Paparó, M.; Weiss, W.; García Hernández, A.; Borkovits, T.; Lampens, P.; Rainer, M.; De Cat, P.; Marcos-Arenal, P.; Vos, J.; Poretti, E.; Baglin, A.; Michel, E.; Baudin, F.; Catala, C.

    2014-07-01

    Context. Pulsating stars in binary systems are ideal laboratories to test stellar evolution and pulsation theory, since a direct, model-independent determination of component masses is possible. The high-precision CoRoT photometry allows a detailed view of the frequency content of pulsating stars, enabling detection of patterns in their distribution. The object HD 51844 is such a case showing periastron brightening instead of eclipses. Aims: We present a comprehensive study of the HD 51844 system, where we derive physical parameters of both components, the pulsation content and frequency patterns. Additionally, we obtain the orbital elements, including masses, and the chemical composition of the stars. Methods: Time series analysis using standard tools was employed to extract the pulsation frequencies. Photospheric abundances of 21 chemical elements were derived by means of spectrum synthesis. We derived orbital elements both by fitting the observed radial velocities and the light curves, and we did asteroseismic modelling as well. Results: We found that HD 51844 is a double lined spectroscopic binary. The determined abundances are consistent with δ Delphini classification. We determined the orbital period (33.498 ± 0.002 d), the eccentricity (0.484 ± 0.020), the mass ratio (0.988 ± 0.02), and the masses to 2.0 ± 0.2 M⊙ for both components. Only one component showed pulsation. Two p modes (f22 and f36) and one g mode (forb) may be tidally excited. Among the 115 frequencies, we detected triplets due to the frequency modulation, frequency differences connected to the orbital period, and unexpected resonances (3:2, 3:5, and 3:4), which is a new discovery for a δ Sct star. The observed frequency differences among the dominant modes suggest a large separation of 2.0-2.2 d-1, which are consistent with models of mean density of 0.063 g cm-3, and with the binary solution and TAMS evolutionary phase for the pulsating component. The binary evolution is in an

  15. Effect of Hydrophobicity on Splash Erosion by a Single Drop Impact: From Model Soil to Real Soil

    NASA Astrophysics Data System (ADS)

    Ahn, Sujung; Doerr, Stefan H.; Douglas, Peter; Bryant, Robert; Hamlett, Christopher A. E.; McHale, Glen; Newton, Michael I.; Shirtcliffe, Neil J.

    2013-04-01

    sand particles had significantly less mobility than glass beads (angle of repose: beads: 21.3 ± 0.7 °, sands: 37.3 ± 0.9 °, p < 0.001, dF = 17), and that sands took longer to flow through a funnel (beads: 1.88 ± 0.02 s, sands: 2.05 ± 0.13 s, p = 0.002, dF = 9). This lower mobility of sands may well be an important factor in the smaller amount of overall splash detachment for sands than beads. Secondly, the water repellency of hydophobized sands, measured by water contact angle (CA) and the Molarity of Ethanol Droplet test (MED), was greater than for identically hydrophobized glass beads (beads: CA 119.6 ± 5.1 °, MED 33%; sands: CA 137.0 ± 2.0 °, MED 36%). This is probably due to the enhancing effect of surface roughness on hydrophobicity. This amplified hydrophobicity can help to explain the enhanced contrast in splash behaviour between hydrophobic and hydrophilic sands. The results show that the enhanced splash detachment observed for hydrophobic model materials in our previous study occurs to an even greater degree in real sands. The findings also suggest that surface roughness and amplified hydrophobicity in real sands need to be considered when translating findings from model materials to real soils. Finally, the results of this study confirm that particle hydrophobicity leads to a greater susceptibility of sands to splash erosion in the initial stage of rain or irrigation events. References: Ahn S, et al. 2012. ESPL. DOI: 10.1002/esp.3364; Fox DM, et al. 2007. Hydro. Proc. 21: 2377-2384; Terry JP and Shakesby RA. 1993. ESPL 18: 519-25 Acknowledgement: This study has been funded by UK EPSRC (EP/H000747/1 and EP/H000704/1).